Enhancer-id	Chr	Start_19	End_19	Start_38	End_38	Internal-key	Genome	vista_id	EnhancerDB_id	Fantom_id	Enhancer_atlas_id	Label	Enhancer/eRNA	sirna_sequences (Forward)	sirna_sequences (Reverse)	shrna_Sequences	sgrna_Sequences	Knockout_effect	tissue type/cell type	Cell_line	Gene (literature)	Target	Knockout	Z-Score	log2FC	beta_1.beta	p_value	CRISPRi_Score	nearest_gene_name	gene_chromosome	gene_start	gene_end	distance_from_enhancer	Size (bp)	Enhancer_distance_to_TSS	Target location 	method	Paper_title	doi	PMID	enhancer_group
enhrx-106476	chr21	27257644	27259705	25885332	25887393	1	hg38	N/A	enh19851	N/A	Enhatls113844	enhancer	APP_E3	|		|	AGTGCCCTGCTAGAGATGCG-AGG	"Deleting APP-E3, located in the last intron of APP, led to a similar downregulation of APP as deleting the APP promoter in both iPSCs and excitatory neurons"	Human induced pluripotent stem cell	WTC11 i3N iPSC	APP	positive	Significant	NA					APP	chr21	25880549	26171128	0	2061	284408	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	359
enhrx-106476	chr21	27257644	27259705	25885332	25887393	2	hg38	N/A	enh19851	N/A	Enhatls113844	enhancer	APP_E3	|		|	ACGTTCTCTCCAGTGTGAAG-TGG	"Deleting APP-E3, located in the last intron of APP, led to a similar downregulation of APP as deleting the APP promoter in both iPSCs and excitatory neurons"	Human induced pluripotent stem cell	WTC11 i3N iPSC	APP	positive	Significant	NA					APP	chr21	25880549	26171128	0	2061	284408	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	359
enhrx-176895	chrX	146994826	146996476	147913308	147914958	3	hg38	N/A	N/A	N/A	Enhatls189137	enhancer	FMR1_E1	|		|	GCCAAAATACTGTAGTAAGG-TGG	Deleting FMR1-E1 reduced expression of FMR1-mCherry in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	FMR3	positive	Significant	NA					FMR1	chrX	147911918	147951125	0	1650	2214	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	6612
enhrx-176895	chrX	146994826	146996476	147913308	147914958	4	hg38	N/A	enh11359	N/A	Enhatls189137	enhancer	FMR1_E1	|		|	GCCAAAATACTGTAGTAAGG-TGG	Deleting FMR1-E1 reduced expression of FMR1-mCherry in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	FMR3	positive	Significant	NA					FMR1	chrX	147911918	147951125	0	1650	2214	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	6612
enhrx-176895	chrX	146994826	146996476	147913308	147914958	5	hg38	N/A	N/A	N/A	Enhatls189137	enhancer	FMR1_E1	|		|	ACAAATCTTAGGATTCATTA-GGG	Deleting FMR1-E1 reduced expression of FMR1-mCherry in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	FMR4	positive	Significant	NA					FMR1	chrX	147911918	147951125	0	1650	2214	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	6612
enhrx-176895	chrX	146994826	146996476	147913308	147914958	6	hg38	N/A	enh11359	N/A	Enhatls189137	enhancer	FMR1_E1	|		|	ACAAATCTTAGGATTCATTA-GGG	Deleting FMR1-E1 reduced expression of FMR1-mCherry in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	FMR4	positive	Significant	NA					FMR1	chrX	147911918	147951125	0	1650	2214	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	6612
enhrx-lit1	chrX	153289958	153291457	154024507	154026006	7	hg38					enhancer	MECP2_E3	|		|	GCTGAAGTCCGGAACGTAGT-CGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA										1499	72461	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	
enhrx-lit2	chrX	153289958	153291457	154024507	154026006	8	hg38					enhancer	MECP2_E3	|		|	CTAGAGTTCCTACCATGGAG-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA										1499	72461	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	
enhrx-177397	chrX	153306160	153307199	154040709	154041748	9	hg38	N/A	enh63973	N/A	Enhatls189670	enhancer	MECP2_E6	|		|	AGTTTGGTCGTGTGTTAAGG-TGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153306160	153307199	154040709	154041748	10	hg38	N/A	enh63973	fant63199	Enhatls189670	enhancer	MECP2_E6	|		|	AGTTTGGTCGTGTGTTAAGG-TGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153306160	153307199	154040709	154041748	11	hg38	N/A	enh63973	N/A	Enhatls189670	enhancer	MECP2_E6	|		|	AGTTTGGTCGTGTGTTAAGG-TGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153306160	153307199	154040709	154041748	12	hg38	N/A	enh63973	N/A	Enhatls189670	enhancer	MECP2_E6	|		|	GCAGAATTACGGAATCAAGG-AGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153306160	153307199	154040709	154041748	13	hg38	N/A	enh63973	fant63199	Enhatls189670	enhancer	MECP2_E6	|		|	GCAGAATTACGGAATCAAGG-AGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153306160	153307199	154040709	154041748	14	hg38	N/A	enh63973	N/A	Enhatls189670	enhancer	MECP2_E6	|		|	GCAGAATTACGGAATCAAGG-AGG	MECP2-E6 caused downregulation of MECP2-EGFP only in excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1039	56489	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153315232	153316313	154049781	154050862	15	hg38	N/A	N/A	N/A	Enhatls189670	enhancer	MECP2_E8	|		|	TCACCTCACGAGTTGATGGG-AGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1081	47396	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153315232	153316313	154049781	154050862	16	hg38	N/A	N/A	N/A	Enhatls189670	enhancer	MECP2_E8	|		|	AGTACACGTAAACTTAGAGG-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1081	47396	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153325926	153327408	154060475	154061957	17	hg38	N/A	N/A	N/A	Enhatls189670	enhancer	MECP2_E10	|		|	TTGGCTCCTTAGCTTCTCCA-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1482	36501	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153325926	153327408	154060475	154061957	18	hg38	N/A	enh78945	N/A	Enhatls189670	enhancer	MECP2_E10	|		|	TTGGCTCCTTAGCTTCTCCA-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1482	36501	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153325926	153327408	154060475	154061957	19	hg38	N/A	N/A	N/A	Enhatls189670	enhancer	MECP2_E10	|		|	AGGGAGTAACGACGTCTGAC-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1482	36501	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-177397	chrX	153325926	153327408	154060475	154061957	20	hg38	N/A	enh78945	N/A	Enhatls189670	enhancer	MECP2_E10	|		|	AGGGAGTAACGACGTCTGAC-TGG	Deletion led to the downregulation of MECP2-EGFP in both iPSCs and excitatory neurons	Human induced pluripotent stem cell	WTC11 i3N iPSC	MECP2	positive	Significant	NA					MECP2	chrX	154021572	154097737	0	1482	36501	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	7114
enhrx-57807	chr15	75016725	75017265	74724384	74724924	21	hg38	N/A	N/A	N/A	Enhatls62189	enhancer	SIN3A_E2	|		|	CTCCAGCTGCCTTTAAACTG-TGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A1	chr15	74719541	74725536	0	540	727036	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4509
enhrx-57807	chr15	75016725	75017265	74724384	74724924	22	hg38	N/A	N/A	N/A	Enhatls62189	enhancer	SIN3A_E2	|		|	TTCTCCTTGGGTGGACAGGG-TGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A1	chr15	74719541	74725536	0	540	727036	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4509
enhrx-57812	chr15	75044130	75044837	74751789	74752496	23	hg38	N/A	N/A	N/A	Enhatls62193	enhancer	SIN3A_E3	|		|	CAACTTGGTCTCTAGGCAGG-GGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	0	707	699548	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4514
enhrx-57813	chr15	75044130	75044837	74751789	74752496	24	hg38	N/A	N/A	N/A	Enhatls62194	enhancer	SIN3A_E3	|		|	CAACTTGGTCTCTAGGCAGG-GGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	0	707	699548	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4515
enhrx-57812	chr15	75044130	75044837	74751789	74752496	25	hg38	N/A	N/A	N/A	Enhatls62193	enhancer	SIN3A_E3	|		|	TTCAGCGTTAGCAAGATTGG-AGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	0	707	699548	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4514
enhrx-57813	chr15	75044130	75044837	74751789	74752496	26	hg38	N/A	N/A	N/A	Enhatls62194	enhancer	SIN3A_E3	|		|	TTCAGCGTTAGCAAGATTGG-AGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	0	707	699548	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4515
enhrx-57815	chr15	75061189	75062152	74768848	74769811	27	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E4	|		|	CACATAGGACAGTTAAGCAG-GGG	"SIN3A-E4 deletion led to reduced SIN3A expression, but compensation was observed through allelic upregulation (Allelic Compensation Effect - ACE)."	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	9323	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	28	hg38	N/A	enh60562	N/A	Enhatls62196	enhancer	SIN3A_E4	|		|	CACATAGGACAGTTAAGCAG-GGG	"SIN3A-E4 deletion led to reduced SIN3A expression, but compensation was observed through allelic upregulation (Allelic Compensation Effect - ACE)."	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5546	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	29	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E4	|		|	TGAGAGCGGCCAGTTCTTCA-CGG	"SIN3A-E4 deletion led to reduced SIN3A expression, but compensation was observed through allelic upregulation (Allelic Compensation Effect - ACE)."	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	9323	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	30	hg38	N/A	enh60562	N/A	Enhatls62196	enhancer	SIN3A_E4	|		|	TGAGAGCGGCCAGTTCTTCA-CGG	"SIN3A-E4 deletion led to reduced SIN3A expression, but compensation was observed through allelic upregulation (Allelic Compensation Effect - ACE)."	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5546	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75069296	75070989	74776955	74778648	31	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E5	|		|	TAAGATGACAAGGGCTACTG-TGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5001	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57816	chr15	75069296	75070989	74776955	74778648	32	hg38	N/A	N/A	fant48871	N/A	enhancer	SIN3A_E5	|		|	TAAGATGACAAGGGCTACTG-TGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	4374	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4518
enhrx-57817	chr15	75069296	75070989	74776955	74778648	33	hg38	N/A	N/A	fant48872	N/A	enhancer	SIN3A_E5	|		|	TAAGATGACAAGGGCTACTG-TGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	3822	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4519
enhrx-57815	chr15	75069296	75070989	74776955	74778648	34	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E5	|		|	CAGCCCAATAATTCCACCAG-AGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5001	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57816	chr15	75069296	75070989	74776955	74778648	35	hg38	N/A	N/A	fant48871	N/A	enhancer	SIN3A_E5	|		|	CAGCCCAATAATTCCACCAG-AGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	4374	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4518
enhrx-57817	chr15	75069296	75070989	74776955	74778648	36	hg38	N/A	N/A	fant48872	N/A	enhancer	SIN3A_E5	|		|	CAGCCCAATAATTCCACCAG-AGG	Deletion resulted in downregulation of SIN3A expression from the affected allele but upregulation from the opposite allele.	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	3822	1693	673889	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4519
enhrx-57815	chr15	75061189	75062152	74768848	74769811	37	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E4_CTCF_sgRNA1	|		|	CAGTGTAGGCTGCCCCCTCG-TGG	Reduced expression of SIN3A	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	9323	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	38	hg38	N/A	enh60562	N/A	Enhatls62196	enhancer	SIN3A_E4_CTCF_sgRNA1	|		|	CAGTGTAGGCTGCCCCCTCG-TGG	Reduced expression of SIN3A	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5546	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	39	hg38	N/A	N/A	N/A	Enhatls62196	enhancer	SIN3A_E4_CTCF_sgRNA2	|		|	TTCTCTAACTGCCCACGAGG-GGG	Reduced expression of SIN3A	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CYP1A2	chr15	74748844	74756607	9323	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-57815	chr15	75061189	75062152	74768848	74769811	40	hg38	N/A	enh60562	N/A	Enhatls62196	enhancer	SIN3A_E4_CTCF_sgRNA2	|		|	TTCTCTAACTGCCCACGAGG-GGG	Reduced expression of SIN3A	Human induced pluripotent stem cell	WTC11 i3N iPSC	SIN3A	negative	Non Significant	NA					CSK	chr15	74782079	74803197	5546	963	682361	|	CRISPR-Cas9	CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription	https://doi.org/10.1101/2024.10.08.616922	39416108	4517
enhrx-100103	chr2	225261525	225261544	224396808	224396827	41	hg19	N/A	N/A	N/A	Enhatls107098	enhancer	V01	|		|	GGCACTTGGAATCCACATGA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL3	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					FAM124B	chr2	224378697	224402107	0	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12029
enhrx-100106	chr2	225302053	225302072	224437336	224437355	42	hg19	N/A	enh19274	N/A	Enhatls107100	enhancer	V02	|		|	GCAGCGTCCGGAGTTGGCAC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL4	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	27434	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12032
enhrx-100106	chr2	225306146	225306165	224441429	224441448	43	hg19	N/A	enh19274	N/A	Enhatls107100	enhancer	V03	|		|	AGCACACAGTCATAACCACA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL5	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	27434	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12032
enhrx-100106	chr2	225308910	225308929	224444193	224444212	44	hg19	N/A	enh19274	N/A	Enhatls107100	enhancer	V04	|		|	GCCACAGCCATGCCCAGTGG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL6	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	25292	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12032
enhrx-100106	chr2	225322128	225322147	224457411	224457430	45	hg19	N/A	N/A	N/A	Enhatls107100	enhancer	V05	|		|	ACTGGCTGGAATCTGCCAAG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL7	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	9514	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12032
enhrx-100106	chr2	225322492	225322511	224457775	224457794	46	hg19	N/A	N/A	N/A	Enhatls107100	enhancer	V06	|		|	CTGATCTTGAGTTGGTCCTT	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL8	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	9514	|	|	3' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12032
enhrx-lit3	chr2	225338000	225338019	224473283	224473302	47	hg19					enhancer	V07	|		|	TTAGGGGCAGGGAGGACCTA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL9	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	3' UTR	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit4	chr2	225338308	225338327	224473591	224473610	48	hg19					enhancer	V08	|		|	GGAAATCTCAAATTACAACA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL10	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	3' UTR	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-100122	chr2	225448737	225448756	224584020	224584039	49	hg19	N/A	N/A	N/A	Enhatls107116	enhancer	V09	|		|	AAATGTACTGTTAACGAACT	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL11	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225448798	225448817	224584081	224584100	50	hg19	N/A	N/A	N/A	Enhatls107116	enhancer	V10	|		|	AGTATATAGGATATAACTTT	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL12	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225449041	225449060	224584324	224584343	51	hg19	N/A	N/A	N/A	Enhatls107116	enhancer	V11	|		|	CAAGAGTTTGTAAAGTGCTT	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL13	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225449304	225449323	224584587	224584606	52	hg19	N/A	N/A	fant10298	Enhatls107116	enhancer	V12	|		|	TCCGCGGCTGCTAGCAGCGC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL14	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225449304	225449323	224584587	224584606	53	hg19	N/A	N/A	N/A	Enhatls107116	enhancer	V12	|		|	TCCGCGGCTGCTAGCAGCGC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL14	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225449290	225449309	224584573	224584592	54	hg19	N/A	N/A	fant10298	Enhatls107116	enhancer	V13	|		|	CGCGGAGTCCTCCCTGTGTG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL15	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-100122	chr2	225449290	225449309	224584573	224584592	55	hg19	N/A	N/A	N/A	Enhatls107116	enhancer	V13	|		|	CGCGGAGTCCTCCCTGTGTG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL15	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	0	|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12048
enhrx-lit5	chr2	225450010	225450029	224585293	224585312	56	hg19					enhancer	V14	|		|	GCGCTCCTCCGCGATGGCGG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL16	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	5' UTR 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit6	chr2	225450524	225450543	224585807	224585826	57	hg19					enhancer	V16	|		|	AGGGGGGAAGTTCGGAGAGC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL17	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit7	chr2	225450595	225450614	224585878	224585897	58	hg19					enhancer	V17	|		|	ATAGTCTTGAGGAGGAGCGT	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL18	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit8	chr2	225450642	225450661	224585925	224585944	59	hg19					enhancer	V18	|		|	AAAAACACAGGAACCAGTTC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL19	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Intron and promoter 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-100123	chr2	225473183	225473202	224608466	224608485	60	hg19	N/A	enh97083	N/A	Enhatls107117	enhancer	V19	|		|	ATCTTTGTCTGACTACCTGC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL20	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	20772	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225473603	225473622	224608886	224608905	61	hg19	N/A	enh97083	N/A	Enhatls107117	enhancer	V20	|		|	AATTTGGCTCGTCCAAACTG	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL21	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	20772	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225473763	225473782	224609046	224609065	62	hg19	N/A	enh97083	N/A	Enhatls107117	enhancer	V21	|		|	ACAGCTTCTACTCTTAGGTC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL22	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	20772	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225506074	225506093	224641357	224641376	63	hg19	N/A	N/A	N/A	Enhatls107117	enhancer	V22	|		|	GATATAGTGAAGTCCAACAA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL23	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	55402	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225506480	225506499	224641763	224641782	64	hg19	N/A	N/A	N/A	Enhatls107117	enhancer	V23	|		|	TGTAGGAGAATGTGCAAGGA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL24	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CUL3	chr2	224470149	224585397	55402	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225509976	225509995	224645259	224645278	65	hg19	N/A	enh53593	N/A	Enhatls107117	enhancer	V24	|		|	CACACACTCAGATGGCTACA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL25	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CCDC195	chr2	224703763	224716365	55165	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-100123	chr2	225510365	225510384	224645648	224645667	66	hg19	N/A	enh53593	N/A	Enhatls107117	enhancer	V25	|		|	GTTAGAGCACCAGGAACCAC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL26	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA					CCDC195	chr2	224703763	224716365	55165	|	|	5' of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	12049
enhrx-lit9	chr2	225378312	225378331	224513595	224513614	67	hg19					enhancer	Exon01	|		|	GACCTAAAATCATTAACATC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL27	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Exon 5 of CUL3 	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit10	chr2	225376188	225376207	224511471	224511490	68	hg19					enhancer	Exon02	|		|	GCACTGCCTTGACAAATCAA	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL28	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Exon 6 of CUL3	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-lit11	chr2	225371570	225371589	224506853	224506872	69	hg19					enhancer	Exon03	|		|	CTTACCTGGATATAGTCAAC	Knockout leads to increased resistance to the BRAF inhibitor following decreased expression of CUL29	Skin	A375 melanoma cells	CUL3	negative	Significantly decreased	NA										|	|	Exon 7 of CUL3	CRISPR-Cas9	High-resolution interrogation of functional elements in the noncoding genome	https://doi.org/10.1126/science.aaf7613	27708104	
enhrx-28240	chr11	46250780	46272762	46229229	46251211	70	hg19	N/A	N/A	N/A	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	43188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	71	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	34556	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	72	hg19	N/A	enh1748	fant38529	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	33864	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	73	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	29046	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	74	hg19	N/A	enh1748	fant38530	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	28510	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	75	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-F	|		|	CACCGACTCGGCCAGATAGCGGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-436	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	23407	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	76	hg19	N/A	N/A	N/A	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	43188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	77	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	34556	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	78	hg19	N/A	enh1748	fant38529	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	33864	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	79	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	29046	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	80	hg19	N/A	enh1748	fant38530	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	28510	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	81	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-A-R	|		|	AAACGTTCCGCTATCTGGCCGAGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-437	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	23407	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	82	hg19	N/A	N/A	N/A	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	43188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	83	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	34556	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	84	hg19	N/A	enh1748	fant38529	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	33864	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	85	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	29046	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	86	hg19	N/A	enh1748	fant38530	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	28510	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	87	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-F	|		|	CACCGCTTCTCTAGGTTTGTAGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-438	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	23407	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	88	hg19	N/A	N/A	N/A	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	43188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	89	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	34556	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	90	hg19	N/A	enh1748	fant38529	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	33864	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	91	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	29046	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	92	hg19	N/A	enh1748	fant38530	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	28510	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-28240	chr11	46250780	46272762	46229229	46251211	93	hg19	N/A	enh1748	N/A	Enhatls30735	enhancer	BC-2-B-R	|		|	AAACGCGCTACAAACCTAGAGAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-439	SLC35F2	direct	Significant	NA	1.646822				CREB3L1	chr11	46277661	46321409	23407	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2909
enhrx-91829	chr2	72339519	72344043	72112389	72116914	94	hg19	N/A	enh18670	N/A	Enhatls98397	enhancer	BC-6-A-F	|		|	CACCGCCCTGTCACAACACGCCGAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-440	ST3GAL5	direct	Significant	NA	1.943582				CYP26B1	chr2	72129237	72147862	10852	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3755
enhrx-91829	chr2	72339519	72344043	72112389	72116914	95	hg19	N/A	enh18670	N/A	Enhatls98397	enhancer	BC-6-A-R	|		|	AAACCTCGGCGTGTTGTGACAGGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-441	ST3GAL5	direct	Significant	NA	1.943582				CYP26B1	chr2	72129237	72147862	10852	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3755
enhrx-91829	chr2	72339519	72344043	72112389	72116914	96	hg19	N/A	enh18670	N/A	Enhatls98397	enhancer	BC-6-B-F	|		|	CACCGATGCTTAAGAAAACGACCTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-442	ST3GAL5	direct	Significant	NA	1.943582				CYP26B1	chr2	72129237	72147862	10852	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3755
enhrx-91829	chr2	72339519	72344043	72112389	72116914	97	hg19	N/A	enh18670	N/A	Enhatls98397	enhancer	BC-6-B-R	|		|	AAACCAGGTCGTTTTCTTAAGCATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-443	ST3GAL5	direct	Significant	NA	1.943582				CYP26B1	chr2	72129237	72147862	10852	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3755
enhrx-27787	chr11	33703776	33717433	33682230	33695887	98	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				KIAA1549L	chr11	33376107	33674102	6402	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	99	hg19	N/A	enh13868	fant38263	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	10710	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	100	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	101	hg19	N/A	enh13868	fant38264	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7595	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	102	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	6275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	103	hg19	N/A	enh13868	fant38265	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	5777	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	104	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-F	|		|	CACCGCCTCATGGGCCTCGCGCAAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-444	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	105	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				KIAA1549L	chr11	33376107	33674102	6402	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	106	hg19	N/A	enh13868	fant38263	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	10710	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	107	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	108	hg19	N/A	enh13868	fant38264	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7595	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	109	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	6275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	110	hg19	N/A	enh13868	fant38265	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	5777	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	111	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-A-R	|		|	AAACATTGCGCGAGGCCCATGAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-445	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	112	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				KIAA1549L	chr11	33376107	33674102	6402	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	113	hg19	N/A	enh13868	fant38263	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	10710	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	114	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	115	hg19	N/A	enh13868	fant38264	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7595	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	116	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	6275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	117	hg19	N/A	enh13868	fant38265	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	5777	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	118	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-F	|		|	CACCGAGCCTGATTCACCCGTCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-446	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	119	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				KIAA1549L	chr11	33376107	33674102	6402	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	120	hg19	N/A	enh13868	fant38263	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	10710	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	121	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	122	hg19	N/A	enh13868	fant38264	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	7595	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	123	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	6275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	124	hg19	N/A	enh13868	fant38265	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	5777	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-27787	chr11	33703776	33717433	33682230	33695887	125	hg19	N/A	enh13868	N/A	Enhatls30240	enhancer	BC-9-B-R	|		|	AAACCGGACGGGTGAATCAGGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-447	HPS5	direct	Significant	NA	1.349995				C11orf91	chr11	33698260	33700826	157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2456
enhrx-123295	chr4	7957749	7963377	7956022	7961650	126	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-A-F	|		|	CACCGGTGTGGAAAGACCCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-448	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4531	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	127	hg19	N/A	enh21353	fant15104	Enhatls131943	enhancer	BC-16-A-F	|		|	CACCGGTGTGGAAAGACCCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-448	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	128	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-A-F	|		|	CACCGGTGTGGAAAGACCCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-448	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	758	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	129	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-A-R	|		|	AAACGACGAGGGTCTTTCCACACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-449	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4531	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	130	hg19	N/A	enh21353	fant15104	Enhatls131943	enhancer	BC-16-A-R	|		|	AAACGACGAGGGTCTTTCCACACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-449	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	131	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-A-R	|		|	AAACGACGAGGGTCTTTCCACACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-449	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	758	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	132	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-B-F	|		|	CACCGTAAGATACCCGGCTGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-450	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4531	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	133	hg19	N/A	enh21353	fant15104	Enhatls131943	enhancer	BC-16-B-F	|		|	CACCGTAAGATACCCGGCTGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-450	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	134	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-B-F	|		|	CACCGTAAGATACCCGGCTGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-450	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	758	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	135	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-B-R	|		|	AAACCCGGCAGCCGGGTATCTTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-451	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4531	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	136	hg19	N/A	enh21353	fant15104	Enhatls131943	enhancer	BC-16-B-R	|		|	AAACCCGGCAGCCGGGTATCTTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-451	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	4045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-123295	chr4	7957749	7963377	7956022	7961650	137	hg19	N/A	enh21353	N/A	Enhatls131943	enhancer	BC-16-B-R	|		|	AAACCCGGCAGCCGGGTATCTTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-451	NA	NA	Non Significant	NA	NA				ABLIM2	chr4	7965311	8158832	758	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	839
enhrx-3720	chr1	32406402	32423516	31940801	31957915	138	hg19	N/A	N/A	N/A	Enhatls4121	enhancer	BC-18-A-F	|		|	CACCGGTTTCGGGCTCGGAAATTT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-452	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	814	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	139	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-A-F	|		|	CACCGGTTTCGGGCTCGGAAATTT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-452	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	7409	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	140	hg19	N/A	enh11723	fant1102	Enhatls4121	enhancer	BC-18-A-F	|		|	CACCGGTTTCGGGCTCGGAAATTT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-452	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12131	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	141	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-A-F	|		|	CACCGGTTTCGGGCTCGGAAATTT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-452	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12396	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	142	hg19	N/A	N/A	N/A	Enhatls4121	enhancer	BC-18-A-R	|		|	AAACAAATTTCCGAGCCCGAAACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-453	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	814	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	143	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-A-R	|		|	AAACAAATTTCCGAGCCCGAAACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-453	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	7409	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	144	hg19	N/A	enh11723	fant1102	Enhatls4121	enhancer	BC-18-A-R	|		|	AAACAAATTTCCGAGCCCGAAACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-453	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12131	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	145	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-A-R	|		|	AAACAAATTTCCGAGCCCGAAACC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-453	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12396	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	146	hg19	N/A	N/A	N/A	Enhatls4121	enhancer	BC-18-B-F	|		|	CACCGTGACTATGAGGCTCTCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-454	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	814	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	147	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-B-F	|		|	CACCGTGACTATGAGGCTCTCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-454	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	7409	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	148	hg19	N/A	enh11723	fant1102	Enhatls4121	enhancer	BC-18-B-F	|		|	CACCGTGACTATGAGGCTCTCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-454	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12131	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	149	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-B-F	|		|	CACCGTGACTATGAGGCTCTCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-454	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12396	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	150	hg19	N/A	N/A	N/A	Enhatls4121	enhancer	BC-18-B-R	|		|	AAACGATCGAGAGCCTCATAGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-455	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	814	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	151	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-B-R	|		|	AAACGATCGAGAGCCTCATAGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-455	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	7409	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	152	hg19	N/A	enh11723	fant1102	Enhatls4121	enhancer	BC-18-B-R	|		|	AAACGATCGAGAGCCTCATAGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-455	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12131	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-3720	chr1	32406402	32423516	31940801	31957915	153	hg19	N/A	enh11723	N/A	Enhatls4121	enhancer	BC-18-B-R	|		|	AAACGATCGAGAGCCTCATAGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-455	ECM1	direct	Significant	NA	1.552066				PTP4A2	chr1	31906420	31942576	12396	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	3719
enhrx-6502	chr1	64126811	64141523	63661140	63675852	154	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-F	|		|	CACCGTGGGATAAGCGCCTCGAAGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-456	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	5	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	155	hg19	N/A	enh11942	fant1841	Enhatls7079	enhancer	BC-30-A-F	|		|	CACCGTGGGATAAGCGCCTCGAAGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-456	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2083	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	156	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-F	|		|	CACCGTGGGATAAGCGCCTCGAAGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-456	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2589	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	157	hg19	N/A	enh11942	fant1842	Enhatls7079	enhancer	BC-30-A-F	|		|	CACCGTGGGATAAGCGCCTCGAAGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-456	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	158	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-F	|		|	CACCGTGGGATAAGCGCCTCGAAGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-456	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2789	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	159	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-R	|		|	AAACCCTTCGAGGCGCTTATCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-457	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	5	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	160	hg19	N/A	enh11942	fant1841	Enhatls7079	enhancer	BC-30-A-R	|		|	AAACCCTTCGAGGCGCTTATCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-457	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2083	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	161	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-R	|		|	AAACCCTTCGAGGCGCTTATCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-457	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2589	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	162	hg19	N/A	enh11942	fant1842	Enhatls7079	enhancer	BC-30-A-R	|		|	AAACCCTTCGAGGCGCTTATCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-457	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	163	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-A-R	|		|	AAACCCTTCGAGGCGCTTATCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-457	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2789	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	164	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-F	|		|	CACCGCCTGGGGCACATCGCTGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-458	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	5	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	165	hg19	N/A	enh11942	fant1841	Enhatls7079	enhancer	BC-30-B-F	|		|	CACCGCCTGGGGCACATCGCTGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-458	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2083	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	166	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-F	|		|	CACCGCCTGGGGCACATCGCTGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-458	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2589	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	167	hg19	N/A	enh11942	fant1842	Enhatls7079	enhancer	BC-30-B-F	|		|	CACCGCCTGGGGCACATCGCTGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-458	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	168	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-F	|		|	CACCGCCTGGGGCACATCGCTGAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-458	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2789	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	169	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-R	|		|	AAACGTTCAGCGATGTGCCCCAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-459	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	5	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	170	hg19	N/A	enh11942	fant1841	Enhatls7079	enhancer	BC-30-B-R	|		|	AAACGTTCAGCGATGTGCCCCAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-459	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2083	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	171	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-R	|		|	AAACGTTCAGCGATGTGCCCCAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-459	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2589	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	172	hg19	N/A	enh11942	fant1842	Enhatls7079	enhancer	BC-30-B-R	|		|	AAACGTTCAGCGATGTGCCCCAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-459	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-6502	chr1	64126811	64141523	63661140	63675852	173	hg19	N/A	enh11942	N/A	Enhatls7079	enhancer	BC-30-B-R	|		|	AAACGTTCAGCGATGTGCCCCAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-459	PARS2	direct	Significant	NA	1.008931				PGM1	chr1	63593410	63660245	2789	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6501
enhrx-94259	chr2	113624822	113650270	112867245	112892693	174	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	27793	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	175	hg19	N/A	enh53239	fant8248	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34763	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	176	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	177	hg19	N/A	N/A	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	36433	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	178	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33620	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	179	hg19	N/A	enh18820	fant8249	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	180	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	181	hg19	N/A	enh18820	fant8250	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30600	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	182	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30485	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	183	hg19	N/A	enh18820	fant8251	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	29549	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	184	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	185	hg19	N/A	enh18820	fant8252	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	186	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19613	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	187	hg19	N/A	enh18820	fant8253	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	188	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-F	|		|	CACCGCAGTCAAAGGATCGTCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-460	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	11567	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	189	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	27793	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	190	hg19	N/A	enh53239	fant8248	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34763	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	191	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	192	hg19	N/A	N/A	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	36433	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	193	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33620	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	194	hg19	N/A	enh18820	fant8249	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	195	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	196	hg19	N/A	enh18820	fant8250	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30600	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	197	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30485	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	198	hg19	N/A	enh18820	fant8251	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	29549	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	199	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	200	hg19	N/A	enh18820	fant8252	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	201	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19613	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	202	hg19	N/A	enh18820	fant8253	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	203	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-A-R	|		|	AAACCCGGGACGATCCTTTGACTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-461	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	11567	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	204	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	27793	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	205	hg19	N/A	enh53239	fant8248	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34763	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	206	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	207	hg19	N/A	N/A	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	36433	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	208	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33620	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	209	hg19	N/A	enh18820	fant8249	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	210	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	211	hg19	N/A	enh18820	fant8250	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30600	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	212	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30485	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	213	hg19	N/A	enh18820	fant8251	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	29549	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	214	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	215	hg19	N/A	enh18820	fant8252	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	216	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19613	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	217	hg19	N/A	enh18820	fant8253	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	218	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-F	|		|	CACCGTGGCTGCTTAACGTACTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-462	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	11567	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	219	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	27793	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	220	hg19	N/A	enh53239	fant8248	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34763	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	221	hg19	N/A	enh53239	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL1B	chr2	112829750	112836816	34928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	222	hg19	N/A	N/A	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	36433	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	223	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33620	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	224	hg19	N/A	enh18820	fant8249	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	33348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	225	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	226	hg19	N/A	enh18820	fant8250	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30600	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	227	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	30485	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	228	hg19	N/A	enh18820	fant8251	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	29549	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	229	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	230	hg19	N/A	enh18820	fant8252	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	25157	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	231	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19613	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	232	hg19	N/A	enh18820	fant8253	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	19423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-94259	chr2	113624822	113650270	112867245	112892693	233	hg19	N/A	enh18820	N/A	Enhatls100938	enhancer	BC-32-B-R	|		|	AAACTGGAGTACGTTAAGCAGCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-463	NA	NA	Non Significant	NA	NA				IL37	chr2	112911164	112918882	11567	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6185
enhrx-122063	chr3	194281819	194303376	194561090	194582647	234	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25880	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	235	hg19	N/A	enh21256	fant14719	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	236	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	17565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	237	hg19	N/A	enh21256	fant14720	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16811	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	238	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16093	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	239	hg19	N/A	enh21256	fant14721	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	15679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	240	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13933	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	241	hg19	N/A	enh21256	fant14722	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13243	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	242	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	243	hg19	N/A	enh21256	fant14723	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11524	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	244	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8412	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	245	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8395	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	246	hg19	N/A	enh21256	fant14724	N/A	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8000	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	247	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	6207	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122064	chr3	194281819	194303376	194561090	194582647	248	hg19	N/A	enh7799	N/A	N/A	enhancer	BC-39-A-F	|		|	CACCGCTGAATCAGCGTCGCCGATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-464	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	3232	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10193
enhrx-122063	chr3	194281819	194303376	194561090	194582647	249	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25880	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	250	hg19	N/A	enh21256	fant14719	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	251	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	17565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	252	hg19	N/A	enh21256	fant14720	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16811	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	253	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16093	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	254	hg19	N/A	enh21256	fant14721	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	15679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	255	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13933	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	256	hg19	N/A	enh21256	fant14722	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13243	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	257	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	258	hg19	N/A	enh21256	fant14723	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11524	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	259	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8412	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	260	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8395	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	261	hg19	N/A	enh21256	fant14724	N/A	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8000	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	262	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	6207	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122064	chr3	194281819	194303376	194561090	194582647	263	hg19	N/A	enh7799	N/A	N/A	enhancer	BC-39-A-R	|		|	AAACGATCGGCGACGCTGATTCAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-465	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	3232	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10193
enhrx-122063	chr3	194281819	194303376	194561090	194582647	264	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25880	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	265	hg19	N/A	enh21256	fant14719	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	266	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	17565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	267	hg19	N/A	enh21256	fant14720	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16811	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	268	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16093	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	269	hg19	N/A	enh21256	fant14721	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	15679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	270	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13933	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	271	hg19	N/A	enh21256	fant14722	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13243	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	272	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	273	hg19	N/A	enh21256	fant14723	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11524	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	274	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8412	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	275	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8395	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	276	hg19	N/A	enh21256	fant14724	N/A	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8000	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	277	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	6207	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122064	chr3	194281819	194303376	194561090	194582647	278	hg19	N/A	enh7799	N/A	N/A	enhancer	BC-39-B-F	|		|	CACCGTATTGGTCTTGTCACGTTAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-466	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	3232	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10193
enhrx-122063	chr3	194281819	194303376	194561090	194582647	279	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25880	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	280	hg19	N/A	enh21256	fant14719	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	25679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	281	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	17565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	282	hg19	N/A	enh21256	fant14720	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16811	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	283	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	16093	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	284	hg19	N/A	enh21256	fant14721	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	15679	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	285	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13933	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	286	hg19	N/A	enh21256	fant14722	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	13243	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	287	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	288	hg19	N/A	enh21256	fant14723	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	11524	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	289	hg19	N/A	enh21256	N/A	Enhatls130644	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8412	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	290	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8395	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	291	hg19	N/A	enh21256	fant14724	N/A	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	8000	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122063	chr3	194281819	194303376	194561090	194582647	292	hg19	N/A	enh21256	N/A	N/A	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	6207	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10192
enhrx-122064	chr3	194281819	194303376	194561090	194582647	293	hg19	N/A	enh7799	N/A	N/A	enhancer	BC-39-B-R	|		|	AAACCTAACGTGACAAGACCAATAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-467	EIF2A	direct	Significant	NA	2.475492				TMEM44	chr3	194587672	194633689	3232	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	10193
enhrx-50282	chr14	61642779	61653066	61176061	61186348	294	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	295	hg19	N/A	enh3252	fant46217	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8546	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	296	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	5542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	297	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1654	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	298	hg19	N/A	N/A	fant46218	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	299	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-A-F	|		|	CACCGAAATTGTTATCCCGGTCAT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-468	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	300	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	301	hg19	N/A	enh3252	fant46217	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8546	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	302	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	5542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	303	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1654	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	304	hg19	N/A	N/A	fant46218	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	305	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-A-R	|		|	AAACATGACCGGGATAACAATTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-469	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	306	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	307	hg19	N/A	enh3252	fant46217	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8546	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	308	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	5542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	309	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1654	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	310	hg19	N/A	N/A	fant46218	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	311	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-B-F	|		|	CACCGTTGCAATGGACTTTAGCGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-470	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	312	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	313	hg19	N/A	enh3252	fant46217	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	8546	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	314	hg19	N/A	enh3252	N/A	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	5542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	315	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1654	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	316	hg19	N/A	N/A	fant46218	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	1542	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-50282	chr14	61642779	61653066	61176061	61186348	317	hg19	N/A	N/A	N/A	Enhatls54241	enhancer	BC-40-B-R	|		|	AAACGGCGCTAAAGTCCATTGCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-471	C14orf132	direct	Significant	NA	1.61642				PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2239
enhrx-94253	chr2	113543748	113582567	112786171	112824990	318	hg19	N/A	N/A	fant8227	N/A	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	2825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6179
enhrx-94254	chr2	113543748	113582567	112786171	112824990	319	hg19	N/A	N/A	fant8228	N/A	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3364	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6180
enhrx-94255	chr2	113543748	113582567	112786171	112824990	320	hg19	N/A	N/A	fant8229	N/A	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6181
enhrx-94256	chr2	113543748	113582567	112786171	112824990	321	hg19	N/A	enh18818	N/A	N/A	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	4576	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	322	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	5901	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	323	hg19	N/A	enh18818	fant8230	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	8888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	324	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9420	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	325	hg19	N/A	enh18818	fant8231	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9692	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	326	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	327	hg19	N/A	enh18818	fant8232	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10456	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	328	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10729	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	329	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	13649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	330	hg19	N/A	N/A	fant8233	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	14732	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	331	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	15543	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	332	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	17336	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	333	hg19	N/A	enh18819	fant8234	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	19749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	334	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20011	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	335	hg19	N/A	enh18819	fant8235	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20482	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	336	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20513	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	337	hg19	N/A	enh18819	fant8236	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	21163	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	338	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	339	hg19	N/A	enh18819	fant8237	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18385	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	340	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18330	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	341	hg19	N/A	enh18819	fant8238	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18139	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	342	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17862	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	343	hg19	N/A	enh18819	fant8239	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17383	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	344	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	345	hg19	N/A	enh18819	fant8240	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	346	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	347	hg19	N/A	enh18819	fant8241	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	15845	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	348	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13961	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	349	hg19	N/A	enh18819	fant8242	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	350	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11540	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	351	hg19	N/A	enh18819	fant8243	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11343	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	352	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	9453	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	353	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	7423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	354	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5634	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	355	hg19	N/A	enh33581	fant8244	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5302	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	356	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5088	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	357	hg19	N/A	enh33581	fant8245	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	4780	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	358	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-F	|		|	CACCGAGATGAGGTGTTGCGTGTCT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-472	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	3133	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94253	chr2	113543748	113582567	112786171	112824990	359	hg19	N/A	N/A	fant8227	N/A	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	2825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6179
enhrx-94254	chr2	113543748	113582567	112786171	112824990	360	hg19	N/A	N/A	fant8228	N/A	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3364	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6180
enhrx-94255	chr2	113543748	113582567	112786171	112824990	361	hg19	N/A	N/A	fant8229	N/A	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6181
enhrx-94256	chr2	113543748	113582567	112786171	112824990	362	hg19	N/A	enh18818	N/A	N/A	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	4576	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	363	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	5901	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	364	hg19	N/A	enh18818	fant8230	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	8888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	365	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9420	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	366	hg19	N/A	enh18818	fant8231	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9692	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	367	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	368	hg19	N/A	enh18818	fant8232	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10456	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	369	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10729	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	370	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	13649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	371	hg19	N/A	N/A	fant8233	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	14732	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	372	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	15543	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	373	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	17336	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	374	hg19	N/A	enh18819	fant8234	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	19749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	375	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20011	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	376	hg19	N/A	enh18819	fant8235	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20482	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	377	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20513	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	378	hg19	N/A	enh18819	fant8236	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	21163	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	379	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	380	hg19	N/A	enh18819	fant8237	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18385	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	381	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18330	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	382	hg19	N/A	enh18819	fant8238	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18139	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	383	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17862	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	384	hg19	N/A	enh18819	fant8239	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17383	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	385	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	386	hg19	N/A	enh18819	fant8240	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	387	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	388	hg19	N/A	enh18819	fant8241	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	15845	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	389	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13961	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	390	hg19	N/A	enh18819	fant8242	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	391	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11540	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	392	hg19	N/A	enh18819	fant8243	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11343	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	393	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	9453	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	394	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	7423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	395	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5634	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	396	hg19	N/A	enh33581	fant8244	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5302	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	397	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5088	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	398	hg19	N/A	enh33581	fant8245	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	4780	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	399	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-A-R	|		|	AAACAGACACGCAACACCTCATCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-473	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	3133	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94253	chr2	113543748	113582567	112786171	112824990	400	hg19	N/A	N/A	fant8227	N/A	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	2825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6179
enhrx-94254	chr2	113543748	113582567	112786171	112824990	401	hg19	N/A	N/A	fant8228	N/A	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3364	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6180
enhrx-94255	chr2	113543748	113582567	112786171	112824990	402	hg19	N/A	N/A	fant8229	N/A	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6181
enhrx-94256	chr2	113543748	113582567	112786171	112824990	403	hg19	N/A	enh18818	N/A	N/A	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	4576	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	404	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	5901	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	405	hg19	N/A	enh18818	fant8230	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	8888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	406	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9420	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	407	hg19	N/A	enh18818	fant8231	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9692	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	408	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	409	hg19	N/A	enh18818	fant8232	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10456	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	410	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10729	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	411	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	13649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	412	hg19	N/A	N/A	fant8233	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	14732	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	413	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	15543	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	414	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	17336	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	415	hg19	N/A	enh18819	fant8234	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	19749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	416	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20011	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	417	hg19	N/A	enh18819	fant8235	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20482	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	418	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20513	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	419	hg19	N/A	enh18819	fant8236	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	21163	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	420	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	421	hg19	N/A	enh18819	fant8237	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18385	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	422	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18330	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	423	hg19	N/A	enh18819	fant8238	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18139	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	424	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17862	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	425	hg19	N/A	enh18819	fant8239	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17383	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	426	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	427	hg19	N/A	enh18819	fant8240	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	428	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	429	hg19	N/A	enh18819	fant8241	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	15845	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	430	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13961	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	431	hg19	N/A	enh18819	fant8242	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	432	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11540	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	433	hg19	N/A	enh18819	fant8243	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11343	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	434	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	9453	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	435	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	7423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	436	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5634	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	437	hg19	N/A	enh33581	fant8244	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5302	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	438	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5088	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	439	hg19	N/A	enh33581	fant8245	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	4780	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	440	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-F	|		|	CACCGGAGTAACTCGTCTGTACTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-474	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	3133	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94253	chr2	113543748	113582567	112786171	112824990	441	hg19	N/A	N/A	fant8227	N/A	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	2825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6179
enhrx-94254	chr2	113543748	113582567	112786171	112824990	442	hg19	N/A	N/A	fant8228	N/A	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3364	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6180
enhrx-94255	chr2	113543748	113582567	112786171	112824990	443	hg19	N/A	N/A	fant8229	N/A	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	3648	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6181
enhrx-94256	chr2	113543748	113582567	112786171	112824990	444	hg19	N/A	enh18818	N/A	N/A	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	4576	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	445	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	5901	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	446	hg19	N/A	enh18818	fant8230	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	8888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	447	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9420	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	448	hg19	N/A	enh18818	fant8231	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	9692	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	449	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	450	hg19	N/A	enh18818	fant8232	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10456	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	451	hg19	N/A	enh18818	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	10729	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	452	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	13649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	453	hg19	N/A	N/A	fant8233	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	14732	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	454	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	15543	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	455	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	17336	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	456	hg19	N/A	enh18819	fant8234	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	19749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	457	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20011	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	458	hg19	N/A	enh18819	fant8235	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20482	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	459	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	20513	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	460	hg19	N/A	enh18819	fant8236	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1A	chr2	112773924	112784493	21163	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	461	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	462	hg19	N/A	enh18819	fant8237	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18385	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	463	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18330	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	464	hg19	N/A	enh18819	fant8238	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	18139	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	465	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17862	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	466	hg19	N/A	enh18819	fant8239	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	17383	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	467	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16999	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	468	hg19	N/A	enh18819	fant8240	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16725	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	469	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	16188	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	470	hg19	N/A	enh18819	fant8241	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	15845	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	471	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13961	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	472	hg19	N/A	enh18819	fant8242	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	13578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	473	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11540	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	474	hg19	N/A	enh18819	fant8243	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	11343	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	475	hg19	N/A	enh18819	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	9453	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	476	hg19	N/A	N/A	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	7423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	477	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5634	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	478	hg19	N/A	enh33581	fant8244	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5302	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	479	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	5088	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	480	hg19	N/A	enh33581	fant8245	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	4780	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-94256	chr2	113543748	113582567	112786171	112824990	481	hg19	N/A	enh33581	N/A	Enhatls100931	enhancer	BC-42-B-R	|		|	AAACTAGTACAGACGAGTTACTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-475	SOCS5	direct	Significant	NA	2.747666				IL1B	chr2	112829750	112836816	3133	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6182
enhrx-100319	chr2	228718280	228730203	227853564	227865487	482	hg19	N/A	enh34369	fant10407	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	18009	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	483	hg19	N/A	enh34369	N/A	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	15632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	484	hg19	N/A	N/A	N/A	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	12502	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	485	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8274	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	486	hg19	N/A	enh19291	fant10408	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	487	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-A-F	|		|	CACCGATTGCAACAATCCCTCGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-476	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	5651	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	488	hg19	N/A	enh34369	fant10407	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	18009	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	489	hg19	N/A	enh34369	N/A	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	15632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	490	hg19	N/A	N/A	N/A	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	12502	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	491	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8274	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	492	hg19	N/A	enh19291	fant10408	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	493	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-A-R	|		|	AAACCATCGAGGGATTGTTGCAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-477	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	5651	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	494	hg19	N/A	enh34369	fant10407	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	18009	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	495	hg19	N/A	enh34369	N/A	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	15632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	496	hg19	N/A	N/A	N/A	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	12502	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	497	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8274	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	498	hg19	N/A	enh19291	fant10408	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	499	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-B-F	|		|	CACCGAATAGCCCTTTGCGGATTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-478	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	5651	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	500	hg19	N/A	enh34369	fant10407	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	18009	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	501	hg19	N/A	enh34369	N/A	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	15632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	502	hg19	N/A	N/A	N/A	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	12502	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	503	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8274	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	504	hg19	N/A	enh19291	fant10408	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	8075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-100319	chr2	228718280	228730203	227853564	227865487	505	hg19	N/A	enh19291	N/A	Enhatls107328	enhancer	BC-43-B-R	|		|	AAACTTAATCCGCAAAGGGCTATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-479	PID1	direct	Significant	NA	1.218489				DAW1	chr2	227871630	227924344	5651	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	12245
enhrx-131255	chr5	34569935	34611259	34569830	34611154	506	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85184	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	507	hg19	N/A	enh22114	fant18191	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85072	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	508	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85001	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	509	hg19	N/A	enh22114	fant18192	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	84712	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	510	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73723	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	511	hg19	N/A	enh22114	fant18193	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73598	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	512	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73110	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	513	hg19	N/A	enh22114	fant18194	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	72839	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	514	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70995	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	515	hg19	N/A	enh22114	fant18195	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	516	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	517	hg19	N/A	enh22114	fant18196	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	69696	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	518	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	519	hg19	N/A	enh22114	fant18197	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68107	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	520	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	63818	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	521	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	61168	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	522	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	58003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	523	hg19	N/A	enh37730	fant18198	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	57804	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	524	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54478	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	525	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	526	hg19	N/A	enh22115	N/A	Enhatls140295	enhancer	BC-44-A-F	|		|	CACCGTTACAGGGTCCGACGAGATG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-480	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	43578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	527	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85184	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	528	hg19	N/A	enh22114	fant18191	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85072	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	529	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85001	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	530	hg19	N/A	enh22114	fant18192	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	84712	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	531	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73723	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	532	hg19	N/A	enh22114	fant18193	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73598	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	533	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73110	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	534	hg19	N/A	enh22114	fant18194	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	72839	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	535	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70995	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	536	hg19	N/A	enh22114	fant18195	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	537	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	538	hg19	N/A	enh22114	fant18196	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	69696	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	539	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	540	hg19	N/A	enh22114	fant18197	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68107	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	541	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	63818	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	542	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	61168	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	543	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	58003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	544	hg19	N/A	enh37730	fant18198	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	57804	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	545	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54478	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	546	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	547	hg19	N/A	enh22115	N/A	Enhatls140295	enhancer	BC-44-A-R	|		|	AAACCATCTCGTCGGACCCTGTAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-481	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	43578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	548	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85184	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	549	hg19	N/A	enh22114	fant18191	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85072	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	550	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85001	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	551	hg19	N/A	enh22114	fant18192	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	84712	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	552	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73723	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	553	hg19	N/A	enh22114	fant18193	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73598	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	554	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73110	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	555	hg19	N/A	enh22114	fant18194	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	72839	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	556	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70995	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	557	hg19	N/A	enh22114	fant18195	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	558	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	559	hg19	N/A	enh22114	fant18196	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	69696	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	560	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	561	hg19	N/A	enh22114	fant18197	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68107	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	562	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	63818	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	563	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	61168	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	564	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	58003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	565	hg19	N/A	enh37730	fant18198	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	57804	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	566	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54478	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	567	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	568	hg19	N/A	enh22115	N/A	Enhatls140295	enhancer	BC-44-B-F	|		|	CACCGCTTAGACCCAACTATAGAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-482	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	43578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	569	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85184	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	570	hg19	N/A	enh22114	fant18191	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85072	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	571	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	85001	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	572	hg19	N/A	enh22114	fant18192	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	84712	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	573	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73723	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	574	hg19	N/A	enh22114	fant18193	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73598	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	575	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	73110	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	576	hg19	N/A	enh22114	fant18194	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	72839	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	577	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70995	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	578	hg19	N/A	enh22114	fant18195	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	579	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	70294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	580	hg19	N/A	enh22114	fant18196	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	69696	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	581	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68825	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	582	hg19	N/A	enh22114	fant18197	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	68107	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	583	hg19	N/A	enh22114	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	63818	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	584	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	61168	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	585	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	58003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	586	hg19	N/A	enh37730	fant18198	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	57804	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	587	hg19	N/A	enh37730	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54478	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	588	hg19	N/A	N/A	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	54348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-131255	chr5	34569935	34611259	34569830	34611154	589	hg19	N/A	enh22115	N/A	Enhatls140295	enhancer	BC-44-B-R	|		|	AAACGTCTATAGTTGGGTCTAAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-483	RPL37	direct	Significant	NA	3.362825				RAI14	chr5	34656327	34832612	43578	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	1046
enhrx-156735	chr8	11731637	11764194	11874128	11906685	590	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	3609	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	591	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	592	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5623	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	593	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	594	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8715	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	595	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12354	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	596	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12464	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	597	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	598	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	599	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	17769	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	600	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18187	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	601	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18771	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	602	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18960	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	603	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19259	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	604	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19612	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	605	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21662	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	606	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	607	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22125	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	608	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	609	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	27656	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	610	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28220	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	611	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28900	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	612	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	29120	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	613	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-A-F	|		|	CACCGAGCGCATTAGCTCAAGACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-484	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	35181	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	614	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	3609	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	615	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	616	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5623	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	617	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	618	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8715	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	619	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12354	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	620	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12464	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	621	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	622	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	623	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	17769	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	624	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18187	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	625	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18771	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	626	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18960	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	627	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19259	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	628	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19612	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	629	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21662	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	630	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	631	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22125	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	632	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	633	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	27656	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	634	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28220	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	635	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28900	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	636	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	29120	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	637	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-A-R	|		|	AAACCGGTCTTGAGCTAATGCGCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-485	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	35181	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	638	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	3609	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	639	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	640	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5623	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	641	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	642	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8715	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	643	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12354	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	644	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12464	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	645	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	646	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	647	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	17769	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	648	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18187	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	649	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18771	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	650	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18960	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	651	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19259	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	652	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19612	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	653	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21662	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	654	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	655	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22125	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	656	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	657	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	27656	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	658	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28220	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	659	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28900	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	660	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	29120	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	661	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-B-F	|		|	CACCGCAAGGTTGAGTCTTATCGAA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-486	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	35181	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	662	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	3609	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	663	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5228	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	664	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	5623	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	665	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8294	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	666	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	8715	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	667	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12354	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	668	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	12464	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	669	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	670	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	16979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	671	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	17769	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	672	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18187	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	673	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18771	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	674	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	18960	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	675	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19259	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	676	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	19612	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	677	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21662	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	678	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	21851	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	679	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22125	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	680	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	22377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	681	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	27656	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	682	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28220	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	683	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	28900	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	684	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	29120	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-156735	chr8	11731637	11764194	11874128	11906685	685	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	BC-45-B-R	|		|	AAACTTCGATAAGACTCAACCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-487	RHOBTB2	direct	Significant	NA	1.372996				CTSB	chr8	11842523	11869533	35181	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	526
enhrx-90919	chr2	55314653	55344035	55087517	55116899	686	hg19	N/A	enh65269	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	687	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	688	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	689	hg19	N/A	enh33346	fant7104	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	690	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	691	hg19	N/A	enh33346	fant7105	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	692	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	693	hg19	N/A	enh33346	fant7106	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	694	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	695	hg19	N/A	enh33346	fant7107	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	696	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	697	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	698	hg19	N/A	N/A	fant7108	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	699	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-F	|		|	CACCGTGACCCCACTACGGAGTTA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-488	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	700	hg19	N/A	enh65269	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	701	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	702	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	703	hg19	N/A	enh33346	fant7104	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	704	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	705	hg19	N/A	enh33346	fant7105	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	706	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	707	hg19	N/A	enh33346	fant7106	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	708	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	709	hg19	N/A	enh33346	fant7107	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	710	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	711	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	712	hg19	N/A	N/A	fant7108	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	713	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-A-R	|		|	AAACTAACTCCGTAGTGGGGTCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-489	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	714	hg19	N/A	enh65269	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	715	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	716	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	717	hg19	N/A	enh33346	fant7104	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	718	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	719	hg19	N/A	enh33346	fant7105	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	720	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	721	hg19	N/A	enh33346	fant7106	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	722	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	723	hg19	N/A	enh33346	fant7107	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	724	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	725	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	726	hg19	N/A	N/A	fant7108	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	727	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-F	|		|	CACCGTTTACGGGGTTGCTGTCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-490	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	728	hg19	N/A	enh65269	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	729	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	730	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	731	hg19	N/A	enh33346	fant7104	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	732	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	733	hg19	N/A	enh33346	fant7105	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	734	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	735	hg19	N/A	enh33346	fant7106	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	736	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	737	hg19	N/A	enh33346	fant7107	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	738	hg19	N/A	enh33346	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	739	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	740	hg19	N/A	N/A	fant7108	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-90919	chr2	55314653	55344035	55087517	55116899	741	hg19	N/A	N/A	N/A	Enhatls97424	enhancer	BC-47-B-R	|		|	AAACCCGGACAGCAACCCCGTAAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-491	DDX11L2	direct	Significant	NA	2.486077				RTN4	chr2	54972186	55112621	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	2845
enhrx-168794	chr9	132305233	132374123	129542954	129611844	742	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60752	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	743	hg19	N/A	enh26057	fant33843	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60534	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	744	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	59132	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	745	hg19	N/A	enh26057	fant33844	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	58315	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	746	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51652	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	747	hg19	N/A	enh26057	fant33845	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	748	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	50204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	749	hg19	N/A	enh26057	fant33846	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	49709	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	750	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	44828	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	751	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	43711	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	752	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	41106	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	753	hg19	N/A	enh26058	fant33847	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40639	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	754	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40254	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	755	hg19	N/A	enh26058	fant33848	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	39398	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	756	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	757	hg19	N/A	enh26058	fant33849	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21074	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	758	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11884	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	759	hg19	N/A	enh26058	fant33850	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	760	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	6363	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	761	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	5003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168795	chr9	132305233	132374123	129542954	129611844	762	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	1307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	763	hg19	N/A	enh102885	fant33851	N/A	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	925	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	764	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	765	hg19	N/A	enh102885	N/A	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	766	hg19	N/A	enh102885	fant33852	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	767	hg19	N/A	N/A	fant33852	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	768	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	769	hg19	N/A	N/A	fant33853	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	770	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-A-F	|		|	CACCGCGGTGTCAATTGATCGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-492	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168794	chr9	132305233	132374123	129542954	129611844	771	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60752	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	772	hg19	N/A	enh26057	fant33843	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60534	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	773	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	59132	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	774	hg19	N/A	enh26057	fant33844	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	58315	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	775	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51652	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	776	hg19	N/A	enh26057	fant33845	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	777	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	50204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	778	hg19	N/A	enh26057	fant33846	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	49709	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	779	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	44828	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	780	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	43711	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	781	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	41106	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	782	hg19	N/A	enh26058	fant33847	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40639	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	783	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40254	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	784	hg19	N/A	enh26058	fant33848	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	39398	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	785	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	786	hg19	N/A	enh26058	fant33849	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21074	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	787	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11884	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	788	hg19	N/A	enh26058	fant33850	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	789	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	6363	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	790	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	5003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168795	chr9	132305233	132374123	129542954	129611844	791	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	1307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	792	hg19	N/A	enh102885	fant33851	N/A	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	925	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	793	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	794	hg19	N/A	enh102885	N/A	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	795	hg19	N/A	enh102885	fant33852	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	796	hg19	N/A	N/A	fant33852	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	797	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	798	hg19	N/A	N/A	fant33853	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	799	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-A-R	|		|	AAACCGCGCGATCAATTGACACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-493	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168794	chr9	132305233	132374123	129542954	129611844	800	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60752	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	801	hg19	N/A	enh26057	fant33843	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60534	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	802	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	59132	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	803	hg19	N/A	enh26057	fant33844	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	58315	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	804	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51652	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	805	hg19	N/A	enh26057	fant33845	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	806	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	50204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	807	hg19	N/A	enh26057	fant33846	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	49709	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	808	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	44828	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	809	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	43711	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	810	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	41106	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	811	hg19	N/A	enh26058	fant33847	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40639	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	812	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40254	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	813	hg19	N/A	enh26058	fant33848	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	39398	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	814	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	815	hg19	N/A	enh26058	fant33849	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21074	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	816	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11884	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	817	hg19	N/A	enh26058	fant33850	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	818	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	6363	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	819	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	5003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168795	chr9	132305233	132374123	129542954	129611844	820	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	1307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	821	hg19	N/A	enh102885	fant33851	N/A	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	925	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	822	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	823	hg19	N/A	enh102885	N/A	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	824	hg19	N/A	enh102885	fant33852	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	825	hg19	N/A	N/A	fant33852	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	826	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	827	hg19	N/A	N/A	fant33853	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	828	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-B-F	|		|	CACCGCATTCCTCGCTCCTAGCGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-494	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168794	chr9	132305233	132374123	129542954	129611844	829	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60752	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	830	hg19	N/A	enh26057	fant33843	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	60534	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	831	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	59132	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	832	hg19	N/A	enh26057	fant33844	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	58315	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	833	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51652	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	834	hg19	N/A	enh26057	fant33845	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	51075	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	835	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	50204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	836	hg19	N/A	enh26057	fant33846	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	49709	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	837	hg19	N/A	enh26057	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	44828	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	838	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	43711	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	839	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	41106	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	840	hg19	N/A	enh26058	fant33847	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40639	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	841	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	40254	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	842	hg19	N/A	enh26058	fant33848	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	39398	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	843	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	844	hg19	N/A	enh26058	fant33849	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	21074	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	845	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11884	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	846	hg19	N/A	enh26058	fant33850	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	11121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	847	hg19	N/A	enh26058	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	6363	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168794	chr9	132305233	132374123	129542954	129611844	848	hg19	N/A	N/A	N/A	Enhatls180679	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	5003	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6061
enhrx-168795	chr9	132305233	132374123	129542954	129611844	849	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	1307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	850	hg19	N/A	enh102885	fant33851	N/A	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	925	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	851	hg19	N/A	enh102885	N/A	N/A	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	852	hg19	N/A	enh102885	N/A	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	853	hg19	N/A	enh102885	fant33852	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	854	hg19	N/A	N/A	fant33852	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	855	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	856	hg19	N/A	N/A	fant33853	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-168795	chr9	132305233	132374123	129542954	129611844	857	hg19	N/A	N/A	N/A	Enhatls180680	enhancer	BC-52-B-R	|		|	AAACCGCGCTAGGAGCGAGGAATGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-495	VCP	direct	Significant	NA	2.350929				NTMT1	chr9	129608883	129636135	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6062
enhrx-14183	chr1	201222582	201247441	201253454	201278313	858	hg19	N/A	enh61946	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				IGFN1	chr1	201190823	201228952	23670	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	859	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	26078	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	860	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16574	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	861	hg19	N/A	enh12516	fant4276	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16415	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	862	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	15270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	863	hg19	N/A	enh12516	fant4277	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	14926	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	864	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	8175	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	865	hg19	N/A	enh12516	fant4278	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	7803	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	866	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	867	hg19	N/A	enh12516	fant4279	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6198	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	868	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	869	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-A-F	|		|	CACCGAACAGCTCCACTGACGCGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-496	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5010	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	870	hg19	N/A	enh61946	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				IGFN1	chr1	201190823	201228952	23670	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	871	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	26078	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	872	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16574	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	873	hg19	N/A	enh12516	fant4276	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16415	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	874	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	15270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	875	hg19	N/A	enh12516	fant4277	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	14926	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	876	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	8175	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	877	hg19	N/A	enh12516	fant4278	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	7803	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	878	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	879	hg19	N/A	enh12516	fant4279	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6198	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	880	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	881	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-A-R	|		|	AAACCCCGCGTCAGTGGAGCTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-497	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5010	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	882	hg19	N/A	enh61946	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				IGFN1	chr1	201190823	201228952	23670	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	883	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	26078	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	884	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16574	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	885	hg19	N/A	enh12516	fant4276	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16415	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	886	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	15270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	887	hg19	N/A	enh12516	fant4277	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	14926	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	888	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	8175	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	889	hg19	N/A	enh12516	fant4278	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	7803	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	890	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	891	hg19	N/A	enh12516	fant4279	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6198	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	892	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	893	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-B-F	|		|	CACCGCGGTGCTATTCCCTGGTACG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-498	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5010	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	894	hg19	N/A	enh61946	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				IGFN1	chr1	201190823	201228952	23670	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	895	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	26078	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	896	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16574	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	897	hg19	N/A	enh12516	fant4276	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	16415	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	898	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	15270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	899	hg19	N/A	enh12516	fant4277	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	14926	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	900	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	8175	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	901	hg19	N/A	enh12516	fant4278	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	7803	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	902	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	903	hg19	N/A	enh12516	fant4279	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	6198	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	904	hg19	N/A	enh12516	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5305	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-14183	chr1	201222582	201247441	201253454	201278313	905	hg19	N/A	N/A	N/A	Enhatls15613	enhancer	BC-54-B-R	|		|	AAACCGTACCAGGGAATAGCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-499	SWT1	direct	Significant	NA	4.940229				PKP1	chr1	201283451	201332993	5010	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	14182
enhrx-88410	chr2	9891288	9922851	9751159	9782722	906	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	90233	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	907	hg19	N/A	enh18248	fant5904	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89915	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	908	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89219	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	909	hg19	N/A	enh18248	fant5905	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	88962	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	910	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	79242	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	911	hg19	N/A	enh18248	fant5906	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	78981	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	912	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63934	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	913	hg19	N/A	enh18248	fant5907	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	914	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63457	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	915	hg19	N/A	enh18248	fant5908	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	916	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	61206	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	917	hg19	N/A	enh18248	fant5909	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	60857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	918	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-F	|		|	CACCGTGCTGCTGAGGATCGCGATA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-500	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	58357	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	919	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	90233	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	920	hg19	N/A	enh18248	fant5904	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89915	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	921	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89219	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	922	hg19	N/A	enh18248	fant5905	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	88962	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	923	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	79242	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	924	hg19	N/A	enh18248	fant5906	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	78981	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	925	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63934	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	926	hg19	N/A	enh18248	fant5907	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	927	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63457	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	928	hg19	N/A	enh18248	fant5908	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	929	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	61206	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	930	hg19	N/A	enh18248	fant5909	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	60857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	931	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-A-R	|		|	AAACTATCGCGATCCTCAGCAGCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-501	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	58357	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	932	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	90233	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	933	hg19	N/A	enh18248	fant5904	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89915	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	934	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89219	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	935	hg19	N/A	enh18248	fant5905	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	88962	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	936	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	79242	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	937	hg19	N/A	enh18248	fant5906	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	78981	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	938	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63934	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	939	hg19	N/A	enh18248	fant5907	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	940	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63457	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	941	hg19	N/A	enh18248	fant5908	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	942	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	61206	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	943	hg19	N/A	enh18248	fant5909	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	60857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	944	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-F	|		|	CACCGCGCCTGTGATAAATCCGAGA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-502	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	58357	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	945	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	90233	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	946	hg19	N/A	enh18248	fant5904	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89915	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	947	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	89219	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	948	hg19	N/A	enh18248	fant5905	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	88962	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	949	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	79242	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	950	hg19	N/A	enh18248	fant5906	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	78981	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	951	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63934	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	952	hg19	N/A	enh18248	fant5907	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63632	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	953	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63457	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	954	hg19	N/A	enh18248	fant5908	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	63329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	955	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	61206	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	956	hg19	N/A	enh18248	fant5909	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	60857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-88410	chr2	9891288	9922851	9751159	9782722	957	hg19	N/A	enh18248	N/A	Enhatls94709	enhancer	BC-63-B-R	|		|	AAACTCTCGGATTTATCACAGGCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-503	CIAO1	direct	Significant	NA	1.689698				TAF1B	chr2	9843442	9934416	58357	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	336
enhrx-154358	chr7	131304027	131320486	131619268	131635727	958	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	59979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	959	hg19	N/A	enh40596	fant27753	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63222	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	960	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63596	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	961	hg19	N/A	enh40596	fant27754	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	962	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	963	hg19	N/A	enh40596	fant27755	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	72965	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	964	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-F	|		|	CACCGCAAGAGATGTCTATCCGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-504	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	73146	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	965	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	59979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	966	hg19	N/A	enh40596	fant27753	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63222	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	967	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63596	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	968	hg19	N/A	enh40596	fant27754	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	969	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	970	hg19	N/A	enh40596	fant27755	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	72965	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	971	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-A-R	|		|	AAACGAACGGATAGACATCTCTTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-505	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	73146	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	972	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	59979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	973	hg19	N/A	enh40596	fant27753	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63222	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	974	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63596	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	975	hg19	N/A	enh40596	fant27754	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	976	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	977	hg19	N/A	enh40596	fant27755	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	72965	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	978	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-F	|		|	CACCGTGATCGCAGGAATATGCCCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-506	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	73146	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	979	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	59979	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	980	hg19	N/A	enh40596	fant27753	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63222	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	981	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	63596	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	982	hg19	N/A	enh40596	fant27754	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	983	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	66716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	984	hg19	N/A	enh40596	fant27755	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	72965	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-154358	chr7	131304027	131320486	131619268	131635727	985	hg19	N/A	enh40596	N/A	Enhatls164953	enhancer	BC-66-B-R	|		|	AAACCGGGCATATTCCTGCGATCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-507	PILRB	direct	Significant	NA	1.822266				PODXL	chr7	131500270	131556628	73146	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7170
enhrx-112061	chr3	5030490	5069291	4988805	5027606	986	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	1997	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	987	hg19	N/A	enh6974	fant11019	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3593	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	988	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	989	hg19	N/A	enh6974	fant11020	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	4767	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	990	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	5126	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	991	hg19	N/A	enh6974	fant11021	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	8971	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	992	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9320	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	993	hg19	N/A	enh6974	fant11022	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9563	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	994	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10113	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	995	hg19	N/A	enh6974	fant11023	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10287	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	996	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	997	hg19	N/A	enh6974	fant11024	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11562	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	998	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11688	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	999	hg19	N/A	enh6974	fant11025	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14665	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1000	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14812	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1001	hg19	N/A	enh6974	fant11026	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23422	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1002	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1003	hg19	N/A	enh6974	fant11027	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24469	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1004	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24658	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1005	hg19	N/A	enh6974	fant11028	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	25823	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1006	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	26701	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1007	hg19	N/A	enh6974	fant11029	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27249	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1008	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27296	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1009	hg19	N/A	enh6974	fant11030	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27951	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1010	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	28275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1011	hg19	N/A	enh6974	fant11031	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1012	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31536	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1013	hg19	N/A	enh6974	fant11032	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1014	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32958	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1015	hg19	N/A	enh6974	fant11033	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1016	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1017	hg19	N/A	enh6974	fant11034	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36514	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1018	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36687	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1019	hg19	N/A	enh6974	fant11035	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	37950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1020	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	38365	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1021	hg19	N/A	enh6974	fant11036	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	40967	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1022	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-F	|		|	CACCGACCCTTGGGAATACCTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-508	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	41583	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1023	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	1997	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1024	hg19	N/A	enh6974	fant11019	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3593	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1025	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1026	hg19	N/A	enh6974	fant11020	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	4767	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1027	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	5126	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1028	hg19	N/A	enh6974	fant11021	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	8971	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1029	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9320	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1030	hg19	N/A	enh6974	fant11022	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9563	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1031	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10113	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1032	hg19	N/A	enh6974	fant11023	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10287	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1033	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1034	hg19	N/A	enh6974	fant11024	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11562	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1035	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11688	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1036	hg19	N/A	enh6974	fant11025	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14665	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1037	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14812	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1038	hg19	N/A	enh6974	fant11026	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23422	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1039	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1040	hg19	N/A	enh6974	fant11027	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24469	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1041	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24658	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1042	hg19	N/A	enh6974	fant11028	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	25823	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1043	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	26701	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1044	hg19	N/A	enh6974	fant11029	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27249	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1045	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27296	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1046	hg19	N/A	enh6974	fant11030	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27951	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1047	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	28275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1048	hg19	N/A	enh6974	fant11031	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1049	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31536	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1050	hg19	N/A	enh6974	fant11032	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1051	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32958	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1052	hg19	N/A	enh6974	fant11033	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1053	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1054	hg19	N/A	enh6974	fant11034	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36514	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1055	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36687	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1056	hg19	N/A	enh6974	fant11035	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	37950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1057	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	38365	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1058	hg19	N/A	enh6974	fant11036	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	40967	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1059	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-A-R	|		|	AAACACGAGGTATTCCCAAGGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-509	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	41583	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1060	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	1997	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1061	hg19	N/A	enh6974	fant11019	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3593	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1062	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1063	hg19	N/A	enh6974	fant11020	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	4767	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1064	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	5126	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1065	hg19	N/A	enh6974	fant11021	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	8971	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1066	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9320	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1067	hg19	N/A	enh6974	fant11022	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9563	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1068	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10113	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1069	hg19	N/A	enh6974	fant11023	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10287	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1070	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1071	hg19	N/A	enh6974	fant11024	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11562	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1072	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11688	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1073	hg19	N/A	enh6974	fant11025	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14665	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1074	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14812	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1075	hg19	N/A	enh6974	fant11026	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23422	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1076	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1077	hg19	N/A	enh6974	fant11027	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24469	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1078	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24658	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1079	hg19	N/A	enh6974	fant11028	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	25823	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1080	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	26701	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1081	hg19	N/A	enh6974	fant11029	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27249	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1082	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27296	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1083	hg19	N/A	enh6974	fant11030	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27951	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1084	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	28275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1085	hg19	N/A	enh6974	fant11031	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1086	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31536	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1087	hg19	N/A	enh6974	fant11032	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1088	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32958	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1089	hg19	N/A	enh6974	fant11033	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1090	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1091	hg19	N/A	enh6974	fant11034	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36514	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1092	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36687	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1093	hg19	N/A	enh6974	fant11035	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	37950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1094	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	38365	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1095	hg19	N/A	enh6974	fant11036	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	40967	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1096	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-F	|		|	CACCGACGAGCGCTCTGGACTCAAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-510	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	41583	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1097	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	1997	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1098	hg19	N/A	enh6974	fant11019	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3593	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1099	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	3892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1100	hg19	N/A	enh6974	fant11020	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	4767	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1101	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	5126	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1102	hg19	N/A	enh6974	fant11021	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	8971	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1103	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9320	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1104	hg19	N/A	enh6974	fant11022	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	9563	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1105	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10113	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1106	hg19	N/A	enh6974	fant11023	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	10287	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1107	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1108	hg19	N/A	enh6974	fant11024	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11562	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1109	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	11688	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1110	hg19	N/A	enh6974	fant11025	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14665	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1111	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	14812	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1112	hg19	N/A	enh6974	fant11026	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23422	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1113	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	23649	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1114	hg19	N/A	enh6974	fant11027	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24469	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1115	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	24658	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1116	hg19	N/A	enh6974	fant11028	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	25823	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1117	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	26701	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1118	hg19	N/A	enh6974	fant11029	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27249	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1119	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27296	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1120	hg19	N/A	enh6974	fant11030	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	27951	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1121	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	28275	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1122	hg19	N/A	enh6974	fant11031	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31325	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1123	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	31536	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1124	hg19	N/A	enh6974	fant11032	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32559	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1125	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	32958	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1126	hg19	N/A	enh6974	fant11033	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34218	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1127	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	34437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1128	hg19	N/A	enh6974	fant11034	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36514	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1129	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	36687	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1130	hg19	N/A	enh6974	fant11035	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	37950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1131	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	38365	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1132	hg19	N/A	enh6974	fant11036	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	40967	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-112061	chr3	5030490	5069291	4988805	5027606	1133	hg19	N/A	enh6974	N/A	Enhatls119915	enhancer	BC-69-B-R	|		|	AAACGTTGAGTCCAGAGCGCTCGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-511	CAV3	direct	Significant	NA	1.972299				BHLHE40	chr3	4979436	4985323	41583	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	190
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1134	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28462	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1135	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1136	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1137	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1138	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	25199	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1139	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	24794	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1140	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	15910	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1141	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	14749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1142	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	BC-71-A-F	|		|	CACCGAAACCCCCCTGTGATACGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-512	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	5764	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1143	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28462	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1144	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1145	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1146	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1147	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	25199	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1148	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	24794	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1149	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	15910	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1150	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	14749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1151	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	BC-71-A-R	|		|	AAACACGTATCACAGGGGGGTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-513	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	5764	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1152	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28462	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1153	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1154	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1155	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1156	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	25199	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1157	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	24794	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1158	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	15910	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1159	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	14749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1160	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	BC-71-B-F	|		|	CACCGCCTACCTGGCAGAGTACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-514	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	5764	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1161	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28462	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1162	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	28204	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1163	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27928	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1164	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	27644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1165	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	25199	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1166	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	24794	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1167	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	15910	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1168	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	14749	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-72480	chr17	48103233	48127378	50025869	50050014	1169	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	BC-71-B-R	|		|	AAACGCGGTACTCTGCCAGGTAGGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-515	UBE2O	direct	Significant	NA	2.444676				ITGA3	chr17	50056109	50090481	5764	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5749
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1170	hg19	N/A	enh36994	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	8809	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1171	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	15312	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1172	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	17169	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1173	hg19	N/A	enh36995	fant16740	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19155	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1174	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19519	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1175	hg19	N/A	enh36995	fant16741	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20049	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1176	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20244	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1177	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	24179	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1178	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	25212	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1179	hg19	N/A	enh36996	fant16742	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27401	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1180	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27645	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1181	hg19	N/A	enh36996	fant16743	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1182	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38801	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1183	hg19	N/A	enh36996	fant16744	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	39460	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1184	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	35491	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1185	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	31976	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1186	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29838	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1187	hg19	N/A	enh21761	fant16745	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1188	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28535	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1189	hg19	N/A	enh21761	fant16746	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1190	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-F	|		|	CACCGACCAACGGTCAAATGCGTGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-516	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	25892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1191	hg19	N/A	enh36994	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	8809	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1192	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	15312	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1193	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	17169	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1194	hg19	N/A	enh36995	fant16740	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19155	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1195	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19519	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1196	hg19	N/A	enh36995	fant16741	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20049	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1197	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20244	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1198	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	24179	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1199	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	25212	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1200	hg19	N/A	enh36996	fant16742	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27401	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1201	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27645	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1202	hg19	N/A	enh36996	fant16743	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1203	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38801	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1204	hg19	N/A	enh36996	fant16744	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	39460	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1205	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	35491	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1206	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	31976	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1207	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29838	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1208	hg19	N/A	enh21761	fant16745	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1209	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28535	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1210	hg19	N/A	enh21761	fant16746	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1211	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-A-R	|		|	AAACGCACGCATTTGACCGTTGGTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-517	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	25892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1212	hg19	N/A	enh36994	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	8809	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1213	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	15312	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1214	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	17169	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1215	hg19	N/A	enh36995	fant16740	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19155	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1216	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19519	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1217	hg19	N/A	enh36995	fant16741	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20049	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1218	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20244	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1219	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	24179	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1220	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	25212	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1221	hg19	N/A	enh36996	fant16742	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27401	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1222	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27645	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1223	hg19	N/A	enh36996	fant16743	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1224	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38801	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1225	hg19	N/A	enh36996	fant16744	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	39460	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1226	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	35491	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1227	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	31976	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1228	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29838	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1229	hg19	N/A	enh21761	fant16745	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1230	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28535	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1231	hg19	N/A	enh21761	fant16746	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1232	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-F	|		|	CACCGGGCCCGTTTGCTAGGATAG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-518	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	25892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1233	hg19	N/A	enh36994	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	8809	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1234	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	15312	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1235	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	17169	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1236	hg19	N/A	enh36995	fant16740	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19155	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1237	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	19519	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1238	hg19	N/A	enh36995	fant16741	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20049	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1239	hg19	N/A	enh36995	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	20244	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1240	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	24179	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1241	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	25212	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1242	hg19	N/A	enh36996	fant16742	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27401	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1243	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	27645	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1244	hg19	N/A	enh36996	fant16743	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38377	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1245	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	38801	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1246	hg19	N/A	enh36996	fant16744	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				BBS12	chr4	122732701	122744942	39460	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1247	hg19	N/A	enh36996	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	35491	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1248	hg19	N/A	N/A	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	31976	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1249	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29838	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1250	hg19	N/A	enh21761	fant16745	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	29437	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1251	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28535	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1252	hg19	N/A	enh21761	fant16746	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	28270	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-128095	chr4	123678707	123721886	122757552	122800731	1253	hg19	N/A	enh21761	N/A	Enhatls136969	enhancer	BC-74-B-R	|		|	AAACCTATCCTAGCAAACGGGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-519	SLC7A11-AS1	direct	Significant	NA	1.34376				FGF2	chr4	122826681	122898236	25892	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5639
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1254	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-A-F	|		|	CACCGTGGGGCTCAAATCCGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-520	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1255	hg19	N/A	enh18213	fant5744	N/A	enhancer	BC-77-A-F	|		|	CACCGTGGGGCTCAAATCCGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-520	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5135	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1256	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-A-F	|		|	CACCGTGGGGCTCAAATCCGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-520	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	2465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1257	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-A-R	|		|	AAACGTACTCGGATTTGAGCCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-521	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1258	hg19	N/A	enh18213	fant5744	N/A	enhancer	BC-77-A-R	|		|	AAACGTACTCGGATTTGAGCCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-521	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5135	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1259	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-A-R	|		|	AAACGTACTCGGATTTGAGCCCCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-521	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	2465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1260	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-B-F	|		|	CACCGGCGTGAGCACTGTCGGTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-522	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1261	hg19	N/A	enh18213	fant5744	N/A	enhancer	BC-77-B-F	|		|	CACCGGCGTGAGCACTGTCGGTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-522	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5135	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1262	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-B-F	|		|	CACCGGCGTGAGCACTGTCGGTCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-522	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	2465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1263	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-B-R	|		|	AAACGGACCGACAGTGCTCACGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-523	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1264	hg19	N/A	enh18213	fant5744	N/A	enhancer	BC-77-B-R	|		|	AAACGGACCGACAGTGCTCACGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-523	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	5135	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-88206	chr2	3582363	3585171	3534773	3537581	1265	hg19	N/A	enh18213	N/A	N/A	enhancer	BC-77-B-R	|		|	AAACGGACCGACAGTGCTCACGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-523	WDR35	direct	Significant	NA	2.198268				RNASEH1	chr2	3541429	3558333	2465	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	132
enhrx-54031	chr15	31506755	31509622	31214552	31217419	1266	hg19	N/A	enh3508	N/A	Enhatls58198	enhancer	BC-78-A-F	|		|	CACCGCGGTGAGGTCCTAGCACGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-524	TM6SF1	direct	Significant	NA	1.655346				TRPM1	chr15	31001064	31161160	51463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	733
enhrx-54031	chr15	31506755	31509622	31214552	31217419	1267	hg19	N/A	enh3508	N/A	Enhatls58198	enhancer	BC-78-A-R	|		|	AAACCGCGTGCTAGGACCTCACCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-525	TM6SF1	direct	Significant	NA	1.655346				TRPM1	chr15	31001064	31161160	51463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	733
enhrx-54031	chr15	31506755	31509622	31214552	31217419	1268	hg19	N/A	enh3508	N/A	Enhatls58198	enhancer	BC-78-B-F	|		|	CACCGAATGACCGTGCGTACTTGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-526	TM6SF1	direct	Significant	NA	1.655346				TRPM1	chr15	31001064	31161160	51463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	733
enhrx-54031	chr15	31506755	31509622	31214552	31217419	1269	hg19	N/A	enh3508	N/A	Enhatls58198	enhancer	BC-78-B-R	|		|	AAACCCAAGTACGCACGGTCATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-527	TM6SF1	direct	Significant	NA	1.655346				TRPM1	chr15	31001064	31161160	51463	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	733
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1270	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-A-F	|		|	CACCGCGGCGAGGTTATATAACGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-528	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1271	hg19	N/A	N/A	fant5522	Enhatls18887	enhancer	BC-80-A-F	|		|	CACCGCGGCGAGGTTATATAACGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-528	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1272	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-A-F	|		|	CACCGCGGCGAGGTTATATAACGCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-528	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1273	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-A-R	|		|	AAACCGCGTTATATAACCTCGCCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-529	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1274	hg19	N/A	N/A	fant5522	Enhatls18887	enhancer	BC-80-A-R	|		|	AAACCGCGTTATATAACCTCGCCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-529	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1275	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-A-R	|		|	AAACCGCGTTATATAACCTCGCCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-529	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1276	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-B-F	|		|	CACCGCGACGGCGAGAACCGATCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-530	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1277	hg19	N/A	N/A	fant5522	Enhatls18887	enhancer	BC-80-B-F	|		|	CACCGCGACGGCGAGAACCGATCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-530	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1278	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-B-F	|		|	CACCGCGACGGCGAGAACCGATCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-530	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1279	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-B-R	|		|	AAACCCGATCGGTTCTCGCCGTCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-531	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1280	hg19	N/A	N/A	fant5522	Enhatls18887	enhancer	BC-80-B-R	|		|	AAACCCGATCGGTTCTCGCCGTCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-531	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-17266	chr1	244011803	244015129	243848501	243851827	1281	hg19	N/A	N/A	N/A	Enhatls18887	enhancer	BC-80-B-R	|		|	AAACCCGATCGGTTCTCGCCGTCGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-531	PLA2G4A	direct	Significant	NA	2.169755				AKT3	chr1	243488232	243851079	0	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	17265
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1282	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-F	|		|	CACCGTACTCACGGGGTAGCTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-532	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	108930	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1283	hg19	N/A	enh37499	fant17659	Enhatls139142	enhancer	BC-81-A-F	|		|	CACCGTACTCACGGGGTAGCTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-532	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1284	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-F	|		|	CACCGTACTCACGGGGTAGCTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-532	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114560	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1285	hg19	N/A	enh37499	fant17660	Enhatls139142	enhancer	BC-81-A-F	|		|	CACCGTACTCACGGGGTAGCTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-532	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118498	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1286	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-F	|		|	CACCGTACTCACGGGGTAGCTCCA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-532	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1287	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-R	|		|	AAACTGGAGCTACCCCGTGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-533	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	108930	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1288	hg19	N/A	enh37499	fant17659	Enhatls139142	enhancer	BC-81-A-R	|		|	AAACTGGAGCTACCCCGTGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-533	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1289	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-R	|		|	AAACTGGAGCTACCCCGTGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-533	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114560	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1290	hg19	N/A	enh37499	fant17660	Enhatls139142	enhancer	BC-81-A-R	|		|	AAACTGGAGCTACCCCGTGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-533	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118498	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1291	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-A-R	|		|	AAACTGGAGCTACCCCGTGAGTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-533	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1292	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-F	|		|	CACCGTAATGCCGAGCTCACTAGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-534	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	108930	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1293	hg19	N/A	enh37499	fant17659	Enhatls139142	enhancer	BC-81-B-F	|		|	CACCGTAATGCCGAGCTCACTAGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-534	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1294	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-F	|		|	CACCGTAATGCCGAGCTCACTAGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-534	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114560	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1295	hg19	N/A	enh37499	fant17660	Enhatls139142	enhancer	BC-81-B-F	|		|	CACCGTAATGCCGAGCTCACTAGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-534	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118498	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1296	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-F	|		|	CACCGTAATGCCGAGCTCACTAGCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-534	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1297	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-R	|		|	AAACGGCTAGTGAGCTCGGCATTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-535	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	108930	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1298	hg19	N/A	enh37499	fant17659	Enhatls139142	enhancer	BC-81-B-R	|		|	AAACGGCTAGTGAGCTCGGCATTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-535	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114307	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1299	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-R	|		|	AAACGGCTAGTGAGCTCGGCATTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-535	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	114560	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1300	hg19	N/A	enh37499	fant17660	Enhatls139142	enhancer	BC-81-B-R	|		|	AAACGGCTAGTGAGCTCGGCATTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-535	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118498	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-130157	chr4	187759894	187767199	186838740	186846045	1301	hg19	N/A	enh37499	N/A	Enhatls139142	enhancer	BC-81-B-R	|		|	AAACGGCTAGTGAGCTCGGCATTAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-535	DCAF4L1	direct	Significant	NA	3.520519				FAT1	chr4	186587793	186726722	118888	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	7701
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1302	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-F	|		|	CACCGATTAAATGGCAAGACCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-536	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	14916	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1303	hg19	N/A	enh6628	fant60015	Enhatls114268	enhancer	BC-83-A-F	|		|	CACCGATTAAATGGCAAGACCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-536	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	20757	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1304	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-F	|		|	CACCGATTAAATGGCAAGACCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-536	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	20423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1305	hg19	N/A	enh6628	fant60016	Enhatls114268	enhancer	BC-83-A-F	|		|	CACCGATTAAATGGCAAGACCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-536	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	19565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1306	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-F	|		|	CACCGATTAAATGGCAAGACCCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-536	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	15105	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1307	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-R	|		|	AAACCCGGGGTCTTGCCATTTAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-537	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	14916	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1308	hg19	N/A	enh6628	fant60015	Enhatls114268	enhancer	BC-83-A-R	|		|	AAACCCGGGGTCTTGCCATTTAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-537	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	20757	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1309	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-R	|		|	AAACCCGGGGTCTTGCCATTTAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-537	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	20423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1310	hg19	N/A	enh6628	fant60016	Enhatls114268	enhancer	BC-83-A-R	|		|	AAACCCGGGGTCTTGCCATTTAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-537	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	19565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1311	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-A-R	|		|	AAACCCGGGGTCTTGCCATTTAATC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-537	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	15105	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1312	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-F	|		|	CACCGAGACGGGTTAACCCCCTAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-538	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	14916	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1313	hg19	N/A	enh6628	fant60015	Enhatls114268	enhancer	BC-83-B-F	|		|	CACCGAGACGGGTTAACCCCCTAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-538	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	20757	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1314	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-F	|		|	CACCGAGACGGGTTAACCCCCTAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-538	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	20423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1315	hg19	N/A	enh6628	fant60016	Enhatls114268	enhancer	BC-83-B-F	|		|	CACCGAGACGGGTTAACCCCCTAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-538	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	19565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1316	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-F	|		|	CACCGAGACGGGTTAACCCCCTAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-538	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	15105	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1317	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-R	|		|	AAACGCTAGGGGGTTAACCCGTCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-539	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	14916	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1318	hg19	N/A	enh6628	fant60015	Enhatls114268	enhancer	BC-83-B-R	|		|	AAACGCTAGGGGGTTAACCCGTCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-539	CSTB	direct	Significant	NA	0.955937				IFNAR1	chr21	33324386	33359864	20757	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1319	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-R	|		|	AAACGCTAGGGGGTTAACCCGTCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-539	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	20423	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1320	hg19	N/A	enh6628	fant60016	Enhatls114268	enhancer	BC-83-B-R	|		|	AAACGCTAGGGGGTTAACCCGTCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-539	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	19565	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-106874	chr21	34751569	34756616	33379263	33384310	1321	hg19	N/A	enh6628	N/A	Enhatls114268	enhancer	BC-83-B-R	|		|	AAACGCTAGGGGGTTAACCCGTCTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-539	CSTB	direct	Significant	NA	0.955937				IFNGR2	chr21	33403412	33479348	15105	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	757
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1322	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-A-F	|		|	CACCGAAAACCACATTTGATAGTCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-540	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	142721	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1323	hg19	N/A	enh29712	fant42311	Enhatls43628	enhancer	BC-84-A-F	|		|	CACCGAAAACCACATTTGATAGTCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-540	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1324	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-A-F	|		|	CACCGAAAACCACATTTGATAGTCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-540	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147430	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1325	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-A-R	|		|	AAACCGACTATCAAATGTGGTTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-541	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	142721	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1326	hg19	N/A	enh29712	fant42311	Enhatls43628	enhancer	BC-84-A-R	|		|	AAACCGACTATCAAATGTGGTTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-541	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1327	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-A-R	|		|	AAACCGACTATCAAATGTGGTTTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-541	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147430	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1328	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-B-F	|		|	CACCGCTATACTCTAAAGAACGGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-542	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	142721	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1329	hg19	N/A	enh29712	fant42311	Enhatls43628	enhancer	BC-84-B-F	|		|	CACCGCTATACTCTAAAGAACGGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-542	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1330	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-B-F	|		|	CACCGCTATACTCTAAAGAACGGGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-542	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147430	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1331	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-B-R	|		|	AAACCCCCGTTCTTTAGAGTATAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-543	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	142721	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1332	hg19	N/A	enh29712	fant42311	Enhatls43628	enhancer	BC-84-B-R	|		|	AAACCCCCGTTCTTTAGAGTATAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-543	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147329	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-40358	chr12	76049022	76055610	75655242	75661830	1333	hg19	N/A	enh29712	N/A	Enhatls43628	enhancer	BC-84-B-R	|		|	AAACCCCCGTTCTTTAGAGTATAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-543	ITFG2	direct	Significant	NA	1.821037				KRR1	chr12	75490862	75511609	147430	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	5668
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1334	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	485171	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1335	hg19	N/A	enh42234	fant33443	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	484497	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1336	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	481137	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1337	hg19	N/A	enh42234	fant33444	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1338	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480799	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1339	hg19	N/A	enh42234	fant33445	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480380	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1340	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480059	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1341	hg19	N/A	enh42234	fant33446	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	479871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1342	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-F	|		|	CACCGTGGTATCATCTAACTTCGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-544	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	477935	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1343	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	485171	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1344	hg19	N/A	enh42234	fant33443	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	484497	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1345	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	481137	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1346	hg19	N/A	enh42234	fant33444	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1347	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480799	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1348	hg19	N/A	enh42234	fant33445	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480380	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1349	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480059	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1350	hg19	N/A	enh42234	fant33446	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	479871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1351	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-A-R	|		|	AAACACGAAGTTAGATGATACCAC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-545	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	477935	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1352	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	485171	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1353	hg19	N/A	enh42234	fant33443	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	484497	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1354	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	481137	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1355	hg19	N/A	enh42234	fant33444	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1356	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480799	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1357	hg19	N/A	enh42234	fant33445	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480380	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1358	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480059	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1359	hg19	N/A	enh42234	fant33446	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	479871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1360	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-F	|		|	CACCGCTCCACTAGGTACTCGACTG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-546	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	477935	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1361	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	485171	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1362	hg19	N/A	enh42234	fant33443	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	484497	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1363	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	481137	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1364	hg19	N/A	enh42234	fant33444	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480857	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1365	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480799	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1366	hg19	N/A	enh42234	fant33445	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480380	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1367	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	480059	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1368	hg19	N/A	enh42234	fant33446	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	479871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-167623	chr9	118430824	118437210	115668545	115674931	1369	hg19	N/A	enh42234	N/A	Enhatls179397	enhancer	BC-85-B-R	|		|	AAACCAGTCGAGTACCTAGTGGAGC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-547	TTC39B	direct	Significant	NA	1.817167				PAPPA	chr9	116153790	116402321	477935	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	4890
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1370	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61754	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1371	hg19	N/A	enh23939	fant25456	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61529	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1372	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58551	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1373	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58361	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1374	hg19	N/A	enh23940	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	54211	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1375	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	53866	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1376	hg19	N/A	enh23941	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	45871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1377	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1378	hg19	N/A	N/A	fant25457	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40334	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1379	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-F	|		|	CACCGGGCATTGTCTGCGGCACCG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-548	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	33561	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1380	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61754	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1381	hg19	N/A	enh23939	fant25456	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61529	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1382	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58551	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1383	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58361	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1384	hg19	N/A	enh23940	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	54211	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1385	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	53866	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1386	hg19	N/A	enh23941	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	45871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1387	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1388	hg19	N/A	N/A	fant25457	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40334	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1389	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-A-R	|		|	AAACCGGTGCCGCAGACAATGCCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-549	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	33561	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1390	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61754	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1391	hg19	N/A	enh23939	fant25456	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61529	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1392	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58551	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1393	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58361	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1394	hg19	N/A	enh23940	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	54211	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1395	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	53866	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1396	hg19	N/A	enh23941	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	45871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1397	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1398	hg19	N/A	N/A	fant25457	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40334	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1399	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-F	|		|	CACCGAATGTTCCTAGCCGGCTACA	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-550	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	33561	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1400	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61754	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1401	hg19	N/A	enh23939	fant25456	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	61529	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1402	hg19	N/A	enh23939	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58551	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1403	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	58361	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1404	hg19	N/A	enh23940	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	54211	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1405	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	53866	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1406	hg19	N/A	enh23941	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	45871	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1407	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1408	hg19	N/A	N/A	fant25457	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	40334	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-147560	chr7	4659400	4682832	4619769	4643201	1409	hg19	N/A	N/A	N/A	Enhatls157694	enhancer	BC-86-B-R	|		|	AAACTGTAGCCGGCTAGGAACATTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-551	GTF2IRD2	direct	Significant	NA	2.373545				FOXK1	chr7	4682294	4771442	33561	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	372
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1410	hg19	N/A	enh52183	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	8400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1411	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	22716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1412	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	25480	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1413	hg19	N/A	enh16472	fant49575	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36162	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1414	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36309	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1415	hg19	N/A	enh16472	fant49576	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	41890	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1416	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	42014	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1417	hg19	N/A	enh16472	fant49577	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1418	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43264	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1419	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	45786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1420	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	49096	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1421	hg19	N/A	enh16473	fant49578	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	61622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1422	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	62121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1423	hg19	N/A	enh16473	fant49579	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1424	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69743	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1425	hg19	N/A	enh16473	fant49580	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1426	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-F	|		|	CACCGGGTTTCTGAATAAAGCCGG	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-552	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	70644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1427	hg19	N/A	enh52183	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	8400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1428	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	22716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1429	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	25480	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1430	hg19	N/A	enh16472	fant49575	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36162	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1431	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36309	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1432	hg19	N/A	enh16472	fant49576	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	41890	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1433	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	42014	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1434	hg19	N/A	enh16472	fant49577	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1435	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43264	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1436	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	45786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1437	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	49096	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1438	hg19	N/A	enh16473	fant49578	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	61622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1439	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	62121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1440	hg19	N/A	enh16473	fant49579	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1441	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69743	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1442	hg19	N/A	enh16473	fant49580	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1443	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-A-R	|		|	AAACCCGGCTTTATTCAGAAACCC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-553	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	70644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1444	hg19	N/A	enh52183	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	8400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1445	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	22716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1446	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	25480	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1447	hg19	N/A	enh16472	fant49575	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36162	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1448	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36309	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1449	hg19	N/A	enh16472	fant49576	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	41890	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1450	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	42014	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1451	hg19	N/A	enh16472	fant49577	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1452	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43264	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1453	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	45786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1454	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	49096	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1455	hg19	N/A	enh16473	fant49578	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	61622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1456	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	62121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1457	hg19	N/A	enh16473	fant49579	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1458	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69743	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1459	hg19	N/A	enh16473	fant49580	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1460	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-F	|		|	CACCGAACACGGACCAGAACGAGT	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-554	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	70644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1461	hg19	N/A	enh52183	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	8400	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1462	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	22716	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1463	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	25480	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1464	hg19	N/A	enh16472	fant49575	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36162	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1465	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	36309	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1466	hg19	N/A	enh16472	fant49576	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	41890	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1467	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	42014	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1468	hg19	N/A	enh16472	fant49577	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43045	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1469	hg19	N/A	enh16472	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	43264	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1470	hg19	N/A	N/A	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	45786	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1471	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	49096	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1472	hg19	N/A	enh16473	fant49578	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	61622	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1473	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	62121	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1474	hg19	N/A	enh16473	fant49579	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69348	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1475	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69743	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1476	hg19	N/A	enh16473	fant49580	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	69950	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-59555	chr15	101211708	101274933	100671503	100734728	1477	hg19	N/A	enh16473	N/A	Enhatls64126	enhancer	BC-87-B-R	|		|	AAACACTCGTTCTGGTCCGTGTTC	"Inhibited target gene expression, cell proliferation, suppressed tumor growth and metastasis"	breast cancer (TNBC) cells	MDA-MB-555	AP3S2	direct	Significant	NA	1.981255				ASB7	chr15	100602588	100651701	70644	|	|	|	CRISPRi	CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression	https://doi.org/10.1158/0008-5472.can-23-3995	39186674	6257
enhrx-34259	chr11	125439112	125454575	125569216	125584680	1478	hg19	N/A	N/A	N/A	Enhatls37166	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8928
enhrx-34259	chr11	125439112	125454575	125569216	125584680	1479	hg19	N/A	N/A	N/A	Enhatls37166	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8928
enhrx-34260	chr11	125439112	125454575	125569216	125584680	1480	hg19	N/A	N/A	N/A	Enhatls37167	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8929
enhrx-34260	chr11	125439112	125454575	125569216	125584680	1481	hg19	N/A	N/A	N/A	Enhatls37167	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8929
enhrx-34261	chr11	125439112	125454575	125569216	125584680	1482	hg19	N/A	N/A	N/A	Enhatls37168	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8930
enhrx-34261	chr11	125439112	125454575	125569216	125584680	1483	hg19	N/A	N/A	N/A	Enhatls37168	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8930
enhrx-34262	chr11	125439112	125454575	125569216	125584680	1484	hg19	N/A	N/A	N/A	Enhatls37169	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8931
enhrx-34262	chr11	125439112	125454575	125569216	125584680	1485	hg19	N/A	N/A	N/A	Enhatls37169	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8931
enhrx-34263	chr11	125439112	125454575	125569216	125584680	1486	hg19	N/A	N/A	N/A	Enhatls37170	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8932
enhrx-34263	chr11	125439112	125454575	125569216	125584680	1487	hg19	N/A	N/A	N/A	Enhatls37170	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8932
enhrx-34264	chr11	125439112	125454575	125569216	125584680	1488	hg19	N/A	N/A	N/A	Enhatls37171	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8933
enhrx-34264	chr11	125439112	125454575	125569216	125584680	1489	hg19	N/A	N/A	N/A	Enhatls37171	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8933
enhrx-34265	chr11	125439112	125454575	125569216	125584680	1490	hg19	N/A	N/A	N/A	Enhatls37172	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8934
enhrx-34265	chr11	125439112	125454575	125569216	125584680	1491	hg19	N/A	N/A	N/A	Enhatls37172	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8934
enhrx-34266	chr11	125439112	125454575	125569216	125584680	1492	hg19	N/A	N/A	N/A	Enhatls37173	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8935
enhrx-34266	chr11	125439112	125454575	125569216	125584680	1493	hg19	N/A	N/A	N/A	Enhatls37173	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8935
enhrx-34267	chr11	125439112	125454575	125569216	125584680	1494	hg19	N/A	N/A	N/A	Enhatls37174	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		EI24	chr11	125569279	125584684	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8936
enhrx-34267	chr11	125439112	125454575	125569216	125584680	1495	hg19	N/A	N/A	N/A	Enhatls37174	enhancer	E11_125334	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	EI24	direct	Significant	NA	-0.11971871		0.00969289		FEZ1	chr11	125442880	125592510	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8936
enhrx-38327	chr12	51454990	51477447	51061207	51083664	1496	hg19	N/A	N/A	N/A	Enhatls41487	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3637
enhrx-38327	chr12	51454990	51477447	51061207	51083664	1497	hg19	N/A	enh14714	N/A	Enhatls41487	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3637
enhrx-38327	chr12	51454990	51477447	51061207	51083664	1498	hg19	N/A	enh14714	N/A	N/A	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3637
enhrx-38327	chr12	51454990	51477447	51061207	51083664	1499	hg19	N/A	enh14714	N/A	Enhatls41488	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3637
enhrx-38327	chr12	51454990	51477447	51061207	51083664	1500	hg19	N/A	N/A	N/A	Enhatls41488	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3637
enhrx-38328	chr12	51454990	51477447	51061207	51083664	1501	hg19	N/A	N/A	N/A	Enhatls41489	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3638
enhrx-38329	chr12	51454990	51477447	51061207	51083664	1502	hg19	N/A	N/A	N/A	Enhatls41490	enhancer	E12_51755	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CSRNP2	direct	Significant	NA	0.052950218		0.035610471		CSRNP2	chr12	51061204	51083643	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3639
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1503	hg19	N/A	enh3890	N/A	N/A	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1504	hg19	N/A	enh3890	N/A	N/A	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		SNN	chr16	11668454	11679152	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1505	hg19	N/A	enh3890	N/A	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1506	hg19	N/A	enh3890	fant49992	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1507	hg19	N/A	enh3890	N/A	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1508	hg19	N/A	enh3890	fant49993	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1509	hg19	N/A	enh3890	N/A	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61172	chr16	11772936	11836734	11679080	11742878	1510	hg19	N/A	N/A	N/A	Enhatls65757	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1467
enhrx-61173	chr16	11772936	11836734	11679080	11742878	1511	hg19	N/A	N/A	N/A	Enhatls65758	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1468
enhrx-61174	chr16	11772936	11836734	11679080	11742878	1512	hg19	N/A	N/A	N/A	Enhatls65759	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1469
enhrx-61175	chr16	11772936	11836734	11679080	11742878	1513	hg19	N/A	N/A	N/A	Enhatls65760	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1470
enhrx-61175	chr16	11772936	11836734	11679080	11742878	1514	hg19	N/A	N/A	fant49994	Enhatls65760	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1470
enhrx-61175	chr16	11772936	11836734	11679080	11742878	1515	hg19	N/A	N/A	N/A	Enhatls65760	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1470
enhrx-61176	chr16	11772936	11836734	11679080	11742878	1516	hg19	N/A	N/A	N/A	Enhatls65761	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1471
enhrx-61177	chr16	11772936	11836734	11679080	11742878	1517	hg19	N/A	N/A	N/A	Enhatls65762	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1472
enhrx-61178	chr16	11772936	11836734	11679080	11742878	1518	hg19	N/A	N/A	N/A	Enhatls65763	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1473
enhrx-61178	chr16	11772936	11836734	11679080	11742878	1519	hg19	N/A	enh3891	N/A	Enhatls65763	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1473
enhrx-61178	chr16	11772936	11836734	11679080	11742878	1520	hg19	N/A	N/A	N/A	Enhatls65763	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1473
enhrx-61179	chr16	11772936	11836734	11679080	11742878	1521	hg19	N/A	N/A	N/A	Enhatls65764	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1474
enhrx-61179	chr16	11772936	11836734	11679080	11742878	1522	hg19	N/A	enh87039	N/A	Enhatls65764	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1474
enhrx-61179	chr16	11772936	11836734	11679080	11742878	1523	hg19	N/A	N/A	N/A	Enhatls65764	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1474
enhrx-61180	chr16	11772936	11836734	11679080	11742878	1524	hg19	N/A	N/A	N/A	Enhatls65765	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1475
enhrx-61181	chr16	11772936	11836734	11679080	11742878	1525	hg19	N/A	N/A	N/A	Enhatls65766	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1476
enhrx-61182	chr16	11772936	11836734	11679080	11742878	1526	hg19	N/A	N/A	N/A	Enhatls65767	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1477
enhrx-61182	chr16	11772936	11836734	11679080	11742878	1527	hg19	N/A	N/A	fant49995	Enhatls65767	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1477
enhrx-61182	chr16	11772936	11836734	11679080	11742878	1528	hg19	N/A	N/A	N/A	Enhatls65767	enhancer	E16_11187	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TXNDC11	direct	Significant	NA	0.066556708		0.031029695		TXNDC11	chr16	11679082	11742857	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	1477
enhrx-lit12	chr16	30204255	30205627	30192934	30194306	1529	hg19					enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	BOLA2B	direct	Significant	NA	-0.063771343		0.018734244							|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	
enhrx-62913	chr16	30087299	30096698	30075978	30085377	1530	hg19	N/A	N/A	N/A	Enhatls67583	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3208
enhrx-62914	chr16	30087299	30096698	30075978	30085377	1531	hg19	N/A	N/A	N/A	Enhatls67584	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3209
enhrx-62915	chr16	30087299	30096698	30075978	30085377	1532	hg19	N/A	N/A	N/A	Enhatls67585	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3210
enhrx-62916	chr16	30087299	30096698	30075978	30085377	1533	hg19	N/A	N/A	N/A	Enhatls67586	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3211
enhrx-62917	chr16	30087299	30096698	30075978	30085377	1534	hg19	N/A	N/A	N/A	Enhatls67587	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3212
enhrx-62918	chr16	30087299	30096698	30075978	30085377	1535	hg19	N/A	N/A	N/A	Enhatls67588	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3213
enhrx-62919	chr16	30087299	30096698	30075978	30085377	1536	hg19	N/A	N/A	N/A	Enhatls67589	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3214
enhrx-62920	chr16	30087299	30096698	30075978	30085377	1537	hg19	N/A	N/A	N/A	Enhatls67590	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	PPP4C	direct	Significant	NA	-0.102282768		0.036028005		PPP4C	chr16	30075993	30085376	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3215
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1538	hg19	N/A	N/A	N/A	Enhatls67716	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1539	hg19	N/A	enh3975	N/A	Enhatls67716	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1540	hg19	N/A	enh3975	N/A	N/A	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1541	hg19	N/A	enh3975	N/A	Enhatls67717	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1542	hg19	N/A	enh3975	N/A	N/A	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1543	hg19	N/A	enh3975	N/A	Enhatls67718	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	5391	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-63039	chr16	30613879	30635333	30602558	30624012	1544	hg19	N/A	N/A	N/A	Enhatls67718	enhancer	E16_30551	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF689	direct	Significant	NA	0.009733192		0.013866237		ZNF689	chr16	30602557	30610389	11506	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3334
enhrx-118397	chr3	125165495	125239041	125446651	125520197	1545	hg19	N/A	N/A	N/A	Enhatls126694	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6526
enhrx-118398	chr3	125165495	125239041	125446651	125520197	1546	hg19	N/A	N/A	N/A	Enhatls126695	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6527
enhrx-118399	chr3	125165495	125239041	125446651	125520197	1547	hg19	N/A	N/A	N/A	Enhatls126696	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6528
enhrx-118400	chr3	125165495	125239041	125446651	125520197	1548	hg19	N/A	N/A	N/A	Enhatls126697	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6529
enhrx-118401	chr3	125165495	125239041	125446651	125520197	1549	hg19	N/A	N/A	N/A	Enhatls126698	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6530
enhrx-118402	chr3	125165495	125239041	125446651	125520197	1550	hg19	N/A	N/A	N/A	Enhatls126699	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6531
enhrx-118403	chr3	125165495	125239041	125446651	125520197	1551	hg19	N/A	N/A	N/A	Enhatls126700	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6532
enhrx-118404	chr3	125165495	125239041	125446651	125520197	1552	hg19	N/A	N/A	N/A	Enhatls126701	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6533
enhrx-118404	chr3	125165495	125239041	125446651	125520197	1553	hg19	N/A	enh54333	N/A	Enhatls126701	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6533
enhrx-118404	chr3	125165495	125239041	125446651	125520197	1554	hg19	N/A	N/A	N/A	Enhatls126701	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6533
enhrx-118405	chr3	125165495	125239041	125446651	125520197	1555	hg19	N/A	N/A	N/A	Enhatls126702	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6534
enhrx-118405	chr3	125165495	125239041	125446651	125520197	1556	hg19	N/A	enh54334	N/A	Enhatls126702	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6534
enhrx-118405	chr3	125165495	125239041	125446651	125520197	1557	hg19	N/A	N/A	N/A	Enhatls126702	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6534
enhrx-118406	chr3	125165495	125239041	125446651	125520197	1558	hg19	N/A	N/A	N/A	Enhatls126703	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6535
enhrx-118406	chr3	125165495	125239041	125446651	125520197	1559	hg19	N/A	enh86492	N/A	Enhatls126703	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6535
enhrx-118406	chr3	125165495	125239041	125446651	125520197	1560	hg19	N/A	N/A	N/A	Enhatls126703	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6535
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1561	hg19	N/A	N/A	N/A	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1562	hg19	N/A	enh35854	N/A	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1563	hg19	N/A	enh35854	fant13357	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1564	hg19	N/A	enh35854	N/A	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1565	hg19	N/A	N/A	N/A	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1566	hg19	N/A	N/A	fant13358	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-118407	chr3	125165495	125239041	125446651	125520197	1567	hg19	N/A	N/A	N/A	Enhatls126704	enhancer	E3_126465	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	SNX4	direct	Significant	NA	0.127934234		0.042522643		SNX4	chr3	125446649	125520202	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6536
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1568	hg19	N/A	N/A	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1569	hg19	N/A	enh7570	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1570	hg19	N/A	N/A	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1571	hg19	N/A	enh7571	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1572	hg19	N/A	N/A	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1573	hg19	N/A	enh87264	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1574	hg19	N/A	N/A	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1575	hg19	N/A	N/A	fant13611	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1576	hg19	N/A	enh7572	fant13611	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1577	hg19	N/A	enh7572	N/A	Enhatls127694	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119334	chr3	136581050	136668665	136862208	136949823	1578	hg19	N/A	enh7572	N/A	N/A	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7463
enhrx-119335	chr3	136581050	136668665	136862208	136949823	1579	hg19	N/A	N/A	N/A	Enhatls127695	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7464
enhrx-119335	chr3	136581050	136668665	136862208	136949823	1580	hg19	N/A	enh107956	N/A	Enhatls127695	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7464
enhrx-119335	chr3	136581050	136668665	136862208	136949823	1581	hg19	N/A	N/A	N/A	Enhatls127695	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7464
enhrx-119335	chr3	136581050	136668665	136862208	136949823	1582	hg19	N/A	enh7573	N/A	Enhatls127695	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7464
enhrx-119335	chr3	136581050	136668665	136862208	136949823	1583	hg19	N/A	N/A	N/A	Enhatls127695	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7464
enhrx-119336	chr3	136581050	136668665	136862208	136949823	1584	hg19	N/A	N/A	N/A	Enhatls127696	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7465
enhrx-119337	chr3	136581050	136668665	136862208	136949823	1585	hg19	N/A	enh20970	N/A	N/A	enhancer	element_843	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	NCK1	direct	Significant	NA	0.012158886		0.01589125		NCK1	chr3	136862207	136951606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	7466
enhrx-155453	chr7	148936742	148952700	149239651	149255609	1586	hg19	N/A	N/A	N/A	Enhatls166089	enhancer	EZH2	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF212	direct	Significant	NA	0.05868104		0.007164262		ZNF212	chr7	149239650	149255606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8265
enhrx-155453	chr7	148936742	148952700	149239651	149255609	1587	hg19	N/A	enh10094	N/A	Enhatls166089	enhancer	EZH2	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF212	direct	Significant	NA	0.05868104		0.007164262		ZNF212	chr7	149239650	149255606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8265
enhrx-155453	chr7	148936742	148952700	149239651	149255609	1588	hg19	N/A	N/A	N/A	Enhatls166089	enhancer	EZH2	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF212	direct	Significant	NA	0.05868104		0.007164262		ZNF212	chr7	149239650	149255606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8265
enhrx-155454	chr7	148936742	148952700	149239651	149255609	1589	hg19	N/A	N/A	N/A	Enhatls166090	enhancer	EZH2	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF212	direct	Significant	NA	0.05868104		0.007164262		ZNF212	chr7	149239650	149255606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8266
enhrx-155455	chr7	148936742	148952700	149239651	149255609	1590	hg19	N/A	N/A	N/A	Enhatls166091	enhancer	EZH2	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZNF212	direct	Significant	NA	0.05868104		0.007164262		ZNF212	chr7	149239650	149255606	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	8267
enhrx-66571	chr16	89627065	89630950	89560657	89564542	1591	hg19	N/A	N/A	N/A	Enhatls71479	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL13	direct	Significant	NA	-0.046856291		0.00982303		RPL13	chr16	89560680	89564542	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6866
enhrx-66572	chr16	89627065	89630950	89560657	89564542	1592	hg19	N/A	N/A	N/A	Enhatls71480	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL13	direct	Significant	NA	-0.046856291		0.00982303		RPL13	chr16	89560680	89564542	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6867
enhrx-66573	chr16	89627065	89630950	89560657	89564542	1593	hg19	N/A	N/A	N/A	Enhatls71481	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL13	direct	Significant	NA	-0.046856291		0.00982303		RPL13	chr16	89560680	89564542	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6868
enhrx-66683	chr16	89985573	90002500	89919165	89936092	1594	hg19	N/A	enh4189	N/A	N/A	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6978
enhrx-66683	chr16	89985573	90002500	89919165	89936092	1595	hg19	N/A	enh4189	N/A	Enhatls71595	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6978
enhrx-66683	chr16	89985573	90002500	89919165	89936092	1596	hg19	N/A	enh4189	fant51537	Enhatls71595	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6978
enhrx-66683	chr16	89985573	90002500	89919165	89936092	1597	hg19	N/A	enh4189	N/A	Enhatls71595	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6978
enhrx-66683	chr16	89985573	90002500	89919165	89936092	1598	hg19	N/A	N/A	N/A	Enhatls71595	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6978
enhrx-66684	chr16	89985573	90002500	89919165	89936092	1599	hg19	N/A	N/A	N/A	Enhatls71596	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6979
enhrx-66685	chr16	89985573	90002500	89919165	89936092	1600	hg19	N/A	N/A	N/A	Enhatls71597	enhancer	RPL13	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TUBB3	direct	Significant	NA	-0.053086924		0.017784128		TUBB3	chr16	89921391	89938761	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	6980
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1601	hg19	N/A	enh17966	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1602	hg19	N/A	enh17966	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1603	hg19	N/A	enh17966	N/A	Enhatls88540	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1604	hg19	N/A	enh17966	N/A	Enhatls88540	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1605	hg19	N/A	N/A	N/A	Enhatls88540	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82567	chr19	17402940	17421045	17292131	17310236	1606	hg19	N/A	N/A	N/A	Enhatls88540	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3537
enhrx-82568	chr19	17402940	17421045	17292131	17310236	1607	hg19	N/A	N/A	N/A	Enhatls88541	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3538
enhrx-82568	chr19	17402940	17421045	17292131	17310236	1608	hg19	N/A	N/A	N/A	Enhatls88541	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3538
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1609	hg19	N/A	N/A	N/A	Enhatls88542	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1610	hg19	N/A	N/A	N/A	Enhatls88542	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1611	hg19	N/A	enh5040	N/A	Enhatls88542	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1612	hg19	N/A	enh5040	N/A	Enhatls88542	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1613	hg19	N/A	enh5040	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82569	chr19	17402940	17421045	17292131	17310236	1614	hg19	N/A	enh5040	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		MRPL34	chr19	17292608	17306843	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3539
enhrx-82570	chr19	17402940	17421045	17292131	17310236	1615	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		ABHD8	chr19	17292130	17310236	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3540
enhrx-82570	chr19	17402940	17421045	17292131	17310236	1616	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ABHD8	direct	Significant	NA	-0.009469842		0.038885387		DDA1	chr19	17309562	17323298	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3540
enhrx-82735	chr19	18043825	18054800	17933016	17943991	1617	hg19	N/A	N/A	N/A	Enhatls88722	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3705
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1618	hg19	N/A	N/A	N/A	Enhatls88723	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1619	hg19	N/A	enh89934	N/A	Enhatls88723	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1620	hg19	N/A	enh89934	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1621	hg19	N/A	enh89934	N/A	Enhatls88724	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1622	hg19	N/A	enh89934	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1623	hg19	N/A	enh89934	N/A	Enhatls88725	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82736	chr19	18043825	18054800	17933016	17943991	1624	hg19	N/A	enh89934	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	CCDC124	direct	Significant	NA	-0.042167675		0.025951258		CCDC124	chr19	17933014	17943991	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3706
enhrx-82961	chr19	19010323	19030206	18899514	18919397	1625	hg19	N/A	N/A	N/A	Enhatls88986	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3931
enhrx-82962	chr19	19010323	19030206	18899514	18919397	1626	hg19	N/A	N/A	N/A	Enhatls88987	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3932
enhrx-82963	chr19	19010323	19030206	18899514	18919397	1627	hg19	N/A	N/A	N/A	Enhatls88988	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3933
enhrx-82964	chr19	19010323	19030206	18899514	18919397	1628	hg19	N/A	N/A	N/A	Enhatls88989	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3934
enhrx-82965	chr19	19010323	19030206	18899514	18919397	1629	hg19	N/A	N/A	N/A	Enhatls88990	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3935
enhrx-82966	chr19	19010323	19030206	18899514	18919397	1630	hg19	N/A	N/A	N/A	Enhatls88991	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3936
enhrx-82967	chr19	19010323	19030206	18899514	18919397	1631	hg19	N/A	N/A	N/A	Enhatls88992	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3937
enhrx-82967	chr19	19010323	19030206	18899514	18919397	1632	hg19	N/A	enh76117	N/A	Enhatls88992	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3937
enhrx-82967	chr19	19010323	19030206	18899514	18919397	1633	hg19	N/A	enh76117	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3937
enhrx-82967	chr19	19010323	19030206	18899514	18919397	1634	hg19	N/A	enh76117	fant56588	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3937
enhrx-82967	chr19	19010323	19030206	18899514	18919397	1635	hg19	N/A	enh76117	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	COPE	direct	Significant	NA	0.085170943		0.014209069		COPE	chr19	18899513	18919387	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3937
enhrx-82814	chr19	18303992	18307758	18193182	18196948	1636	hg19	N/A	N/A	N/A	Enhatls88803	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MPV17L2	direct	Significant	NA	-0.05213968		0.045381533		MPV17L2	chr19	18193217	18196948	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3784
enhrx-82815	chr19	18303992	18307758	18193182	18196948	1637	hg19	N/A	N/A	N/A	Enhatls88804	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MPV17L2	direct	Significant	NA	-0.05213968		0.045381533		MPV17L2	chr19	18193217	18196948	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3785
enhrx-82816	chr19	18303992	18307758	18193182	18196948	1638	hg19	N/A	N/A	N/A	Enhatls88805	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MPV17L2	direct	Significant	NA	-0.05213968		0.045381533		MPV17L2	chr19	18193217	18196948	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3786
enhrx-82817	chr19	18303992	18307758	18193182	18196948	1639	hg19	N/A	N/A	N/A	Enhatls88806	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MPV17L2	direct	Significant	NA	-0.05213968		0.045381533		MPV17L2	chr19	18193217	18196948	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3787
enhrx-82503	chr19	17186591	17325346	17075781	17214537	1640	hg19	N/A	N/A	fant56486	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3473
enhrx-82504	chr19	17186591	17325346	17075781	17214537	1641	hg19	N/A	N/A	fant56487	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3474
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1642	hg19	N/A	N/A	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1643	hg19	N/A	enh5037	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1644	hg19	N/A	enh5037	fant56488	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1645	hg19	N/A	enh5037	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1646	hg19	N/A	enh5037	fant56489	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1647	hg19	N/A	enh5037	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1648	hg19	N/A	enh5037	fant56490	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1649	hg19	N/A	enh5037	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82505	chr19	17186591	17325346	17075781	17214537	1650	hg19	N/A	N/A	N/A	Enhatls88473	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3475
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1651	hg19	N/A	N/A	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1652	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1653	hg19	N/A	enh5038	fant56491	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1654	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1655	hg19	N/A	enh5038	fant56492	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1656	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1657	hg19	N/A	enh5038	fant56493	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1658	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1659	hg19	N/A	enh5038	fant56494	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1660	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1661	hg19	N/A	enh5038	fant56495	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1662	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1663	hg19	N/A	enh5038	fant56496	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1664	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1665	hg19	N/A	enh5038	fant56497	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1666	hg19	N/A	enh5038	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82506	chr19	17186591	17325346	17075781	17214537	1667	hg19	N/A	N/A	N/A	Enhatls88474	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3476
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1668	hg19	N/A	N/A	N/A	Enhatls88475	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1669	hg19	N/A	enh17965	N/A	Enhatls88475	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1670	hg19	N/A	enh17965	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1671	hg19	N/A	enh17965	N/A	Enhatls88476	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1672	hg19	N/A	enh17965	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1673	hg19	N/A	enh17965	N/A	Enhatls88477	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1674	hg19	N/A	enh17965	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1675	hg19	N/A	enh17965	N/A	Enhatls88478	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82507	chr19	17186591	17325346	17075781	17214537	1676	hg19	N/A	N/A	N/A	Enhatls88478	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3477
enhrx-82508	chr19	17186591	17325346	17075781	17214537	1677	hg19	N/A	N/A	N/A	Enhatls88479	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3478
enhrx-82509	chr19	17186591	17325346	17075781	17214537	1678	hg19	N/A	N/A	N/A	Enhatls88480	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3479
enhrx-82510	chr19	17186591	17325346	17075781	17214537	1679	hg19	N/A	N/A	N/A	Enhatls88481	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3480
enhrx-82511	chr19	17186591	17325346	17075781	17214537	1680	hg19	N/A	N/A	N/A	Enhatls88482	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3481
enhrx-82512	chr19	17186591	17325346	17075781	17214537	1681	hg19	N/A	N/A	N/A	Enhatls88483	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3482
enhrx-82513	chr19	17186591	17325346	17075781	17214537	1682	hg19	N/A	N/A	N/A	Enhatls88484	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3483
enhrx-82514	chr19	17186591	17325346	17075781	17214537	1683	hg19	N/A	N/A	N/A	Enhatls88485	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3484
enhrx-82515	chr19	17186591	17325346	17075781	17214537	1684	hg19	N/A	N/A	N/A	Enhatls88486	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3485
enhrx-82516	chr19	17186591	17325346	17075781	17214537	1685	hg19	N/A	N/A	N/A	Enhatls88487	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3486
enhrx-82517	chr19	17186591	17325346	17075781	17214537	1686	hg19	N/A	N/A	N/A	Enhatls88488	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3487
enhrx-82518	chr19	17186591	17325346	17075781	17214537	1687	hg19	N/A	N/A	N/A	Enhatls88489	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3488
enhrx-82519	chr19	17186591	17325346	17075781	17214537	1688	hg19	N/A	N/A	N/A	Enhatls88490	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3489
enhrx-82520	chr19	17186591	17325346	17075781	17214537	1689	hg19	N/A	N/A	N/A	Enhatls88491	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3490
enhrx-82521	chr19	17186591	17325346	17075781	17214537	1690	hg19	N/A	N/A	N/A	Enhatls88492	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3491
enhrx-82521	chr19	17186591	17325346	17075781	17214537	1691	hg19	N/A	N/A	fant56498	Enhatls88492	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3491
enhrx-82521	chr19	17186591	17325346	17075781	17214537	1692	hg19	N/A	N/A	N/A	Enhatls88492	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3491
enhrx-82522	chr19	17186591	17325346	17075781	17214537	1693	hg19	N/A	N/A	N/A	Enhatls88493	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3492
enhrx-82523	chr19	17186591	17325346	17075781	17214537	1694	hg19	N/A	N/A	N/A	Enhatls88494	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3493
enhrx-82524	chr19	17186591	17325346	17075781	17214537	1695	hg19	N/A	N/A	N/A	Enhatls88495	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3494
enhrx-82525	chr19	17186591	17325346	17075781	17214537	1696	hg19	N/A	N/A	N/A	Enhatls88496	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3495
enhrx-82526	chr19	17186591	17325346	17075781	17214537	1697	hg19	N/A	N/A	N/A	Enhatls88497	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3496
enhrx-82527	chr19	17186591	17325346	17075781	17214537	1698	hg19	N/A	N/A	N/A	Enhatls88498	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3497
enhrx-82528	chr19	17186591	17325346	17075781	17214537	1699	hg19	N/A	N/A	N/A	Enhatls88499	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3498
enhrx-82529	chr19	17186591	17325346	17075781	17214537	1700	hg19	N/A	N/A	N/A	Enhatls88500	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3499
enhrx-82530	chr19	17186591	17325346	17075781	17214537	1701	hg19	N/A	N/A	N/A	Enhatls88501	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3500
enhrx-82531	chr19	17186591	17325346	17075781	17214537	1702	hg19	N/A	N/A	N/A	Enhatls88502	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3501
enhrx-82532	chr19	17186591	17325346	17075781	17214537	1703	hg19	N/A	N/A	N/A	Enhatls88503	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3502
enhrx-82533	chr19	17186591	17325346	17075781	17214537	1704	hg19	N/A	N/A	N/A	Enhatls88504	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	MYO9B	direct	Significant	NA	0.009006174		0.014781891		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3503
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1705	hg19	N/A	enh108720	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1706	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1707	hg19	N/A	enh108720	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1708	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1709	hg19	N/A	enh108720	N/A	N/A	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-82721	chr19	17970685	17974962	17859876	17864153	1710	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	RPL18A	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL18A	direct	Significant	NA	-0.149321668		4.44E-28		RPL18A	chr19	17859909	17864153	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	3691
enhrx-44926	chr13	27825446	27830828	27251309	27256691	1711	hg19	N/A	N/A	N/A	Enhatls48467	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL21	direct	Significant	NA	-0.126559378		0.000351364		RPL21	chr13	27251557	27256568	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	548
enhrx-44927	chr13	27825446	27830828	27251309	27256691	1712	hg19	N/A	N/A	N/A	Enhatls48468	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL21	direct	Significant	NA	-0.126559378		0.000351364		RPL21	chr13	27251557	27256568	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	549
enhrx-44928	chr13	27825446	27830828	27251309	27256691	1713	hg19	N/A	N/A	N/A	Enhatls48469	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL21	direct	Significant	NA	-0.126559378		0.000351364		RPL21	chr13	27251557	27256568	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	550
enhrx-44928	chr13	27825446	27830828	27251309	27256691	1714	hg19	N/A	enh2730	N/A	Enhatls48469	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL21	direct	Significant	NA	-0.126559378		0.000351364		RPL21	chr13	27251557	27256568	1	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	550
enhrx-44916	chr13	27640293	27746033	27066156	27171896	1715	hg19	N/A	N/A	N/A	Enhatls48455	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	538
enhrx-44917	chr13	27640293	27746033	27066156	27171896	1716	hg19	N/A	N/A	N/A	Enhatls48456	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	539
enhrx-44918	chr13	27640293	27746033	27066156	27171896	1717	hg19	N/A	N/A	N/A	Enhatls48457	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	540
enhrx-44918	chr13	27640293	27746033	27066156	27171896	1718	hg19	N/A	enh43885	N/A	Enhatls48457	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	540
enhrx-44918	chr13	27640293	27746033	27066156	27171896	1719	hg19	N/A	N/A	N/A	Enhatls48457	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	540
enhrx-44919	chr13	27640293	27746033	27066156	27171896	1720	hg19	N/A	N/A	N/A	Enhatls48458	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	541
enhrx-44920	chr13	27640293	27746033	27066156	27171896	1721	hg19	N/A	N/A	N/A	Enhatls48459	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	542
enhrx-44921	chr13	27640293	27746033	27066156	27171896	1722	hg19	N/A	N/A	N/A	Enhatls48460	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	543
enhrx-44921	chr13	27640293	27746033	27066156	27171896	1723	hg19	N/A	enh80445	N/A	Enhatls48460	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	543
enhrx-44921	chr13	27640293	27746033	27066156	27171896	1724	hg19	N/A	enh80445	fant43935	Enhatls48460	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	543
enhrx-44921	chr13	27640293	27746033	27066156	27171896	1725	hg19	N/A	enh80445	N/A	Enhatls48460	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	543
enhrx-44921	chr13	27640293	27746033	27066156	27171896	1726	hg19	N/A	N/A	N/A	Enhatls48460	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	543
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1727	hg19	N/A	N/A	N/A	Enhatls48461	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1728	hg19	N/A	enh30144	N/A	Enhatls48461	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1729	hg19	N/A	enh30144	N/A	N/A	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1730	hg19	N/A	enh30144	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1731	hg19	N/A	enh30144	fant43936	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1732	hg19	N/A	enh30144	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1733	hg19	N/A	enh30144	fant43937	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1734	hg19	N/A	enh30144	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1735	hg19	N/A	N/A	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1736	hg19	N/A	enh43886	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1737	hg19	N/A	N/A	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1738	hg19	N/A	enh86965	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1739	hg19	N/A	N/A	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1740	hg19	N/A	enh51479	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1741	hg19	N/A	N/A	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1742	hg19	N/A	N/A	fant43938	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1743	hg19	N/A	N/A	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1744	hg19	N/A	enh62331	N/A	Enhatls48462	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1745	hg19	N/A	enh62331	N/A	N/A	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1746	hg19	N/A	enh62331	N/A	Enhatls48463	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-44922	chr13	27640293	27746033	27066156	27171896	1747	hg19	N/A	N/A	N/A	Enhatls48463	enhancer	RPL21	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	USP12	direct	Significant	N	0.017209679		0.047799622		USP12	chr13	27066155	27171811	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	544
enhrx-lit13	chr8	146015150	146017972	144789765	144792587	1748	hg19					enhancer	RPL8	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	RPL8	direct	Significant	NA	-0.214032241		1.88E-14							|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	
enhrx-78807	chr18	71815746	71826197	74148511	74158962	1749	hg19	N/A	N/A	fant55520	N/A	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TIMM21	direct	Significant	NA	-0.084906806		0.010761115		TIMM21	chr18	74148522	74160531	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2825
enhrx-78808	chr18	71815746	71826197	74148511	74158962	1750	hg19	N/A	N/A	N/A	Enhatls84549	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TIMM21	direct	Significant	NA	-0.084906806		0.010761115		TIMM21	chr18	74148522	74160531	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2826
enhrx-78809	chr18	71815746	71826197	74148511	74158962	1751	hg19	N/A	N/A	N/A	Enhatls84550	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	TIMM21	direct	Significant	NA	-0.084906806		0.010761115		TIMM21	chr18	74148522	74160531	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2827
enhrx-78867	chr18	72907063	72921303	75195108	75209348	1752	hg19	N/A	N/A	N/A	Enhatls84610	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZADH2	direct	Significant	NA	0.054163207		0.037736586		PTGR3	chr18	75195112	75209139	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2885
enhrx-78868	chr18	72907063	72921303	75195108	75209348	1753	hg19	N/A	N/A	N/A	Enhatls84611	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZADH2	direct	Significant	NA	0.054163207		0.037736586		PTGR3	chr18	75195112	75209139	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2886
enhrx-78868	chr18	72907063	72921303	75195108	75209348	1754	hg19	N/A	N/A	fant55547	Enhatls84611	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZADH2	direct	Significant	NA	0.054163207		0.037736586		PTGR3	chr18	75195112	75209139	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2886
enhrx-78868	chr18	72907063	72921303	75195108	75209348	1755	hg19	N/A	N/A	N/A	Enhatls84611	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZADH2	direct	Significant	NA	0.054163207		0.037736586		PTGR3	chr18	75195112	75209139	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2886
enhrx-78869	chr18	72907063	72921303	75195108	75209348	1756	hg19	N/A	N/A	fant55548	N/A	enhancer	TSHZ1_Roman	|		|		significant decrease in gene expression upon knockout	Bone; Marrow	K562 cells	ZADH2	direct	Significant	NA	0.054163207		0.037736586		PTGR3	chr18	75195112	75209139	0	|	|	|	CRISPR-Cas9	Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs	https://doi.org/10.1038/s41551-024-01204-8	38778183	2887
enhrx-56144	chr15	53747680	53747699	53455483	53455502	1757	hg38	N/A	enh57665	N/A	Enhatls60405	enhancer	ONECUT1e-664kb Knockout Spacer 1	|		|	TAGGCAGGTTATGCCACTCA	knockout led to a near-complete loss of ONECUT1 expression and significantly impaired pancreatic differentiation	Skin; Foreskin	human pluripotent stem cells (hPSCs)	ONECUT1 	direct	Significant	NA					WDR72	chr15	53513740	53762878	56323	|	|	|	CRISPRi	CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant	https://doi.org/10.1016/j.celrep.2024.114640	39163202	2846
enhrx-56144	chr15	53746945	53746964	53454748	53454767	1758	hg38	N/A	enh57665	N/A	Enhatls60405	enhancer	ONECUT1e-664kb Knockout Spacer 2	|		|	GTACCTGGATGTCCTGATCT	knockout led to a near-complete loss of ONECUT1 expression and significantly impaired pancreatic differentiation	Skin; Foreskin	human pluripotent stem cells (hPSCs)	ONECUT1 	direct	Significant	NA					WDR72	chr15	53513740	53762878	56323	|	|	|	CRISPRi	CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant	https://doi.org/10.1016/j.celrep.2024.114640	39163202	2846
enhrx-142402	chr6	58776479	58779382	58450201	58453104	1759	hg19	N/A	N/A	N/A	Enhatls152235	enhancer	2A	|		|	CACCGTTTATAGCGCATTGAGCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRIM2	chr6	57314804	57646850	713848				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3990
enhrx-142402	chr6	58776479	58779382	58450201	58453104	1760	hg19	N/A	N/A	N/A	Enhatls152235	enhancer	2B	|		|	CACCGAAGGCGCTCTAATATCCGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRIM2	chr6	57314804	57646850	713848				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3990
enhrx-83380	chr19	30149220	30182121	29658313	29691214	1761	hg19	N/A	N/A	N/A	Enhatls89430	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	5094				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4350
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1762	hg19	N/A	N/A	N/A	Enhatls89431	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1763	hg19	N/A	enh18006	N/A	Enhatls89431	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1764	hg19	N/A	enh18006	fant56733	Enhatls89431	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1765	hg19	N/A	enh18006	N/A	Enhatls89431	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1766	hg19	N/A	N/A	N/A	Enhatls89431	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1767	hg19	N/A	N/A	N/A	Enhatls89432	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1768	hg19	N/A	enh18007	N/A	Enhatls89432	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	1162				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1769	hg19	N/A	enh18007	fant56734	Enhatls89432	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	5121				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1770	hg19	N/A	enh18007	N/A	Enhatls89432	enhancer	4A	|		|	CACCGCCCTCAAAGACTATAGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					C19orf12	chr19	29698936	29715789	2069				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83380	chr19	30149220	30182121	29658313	29691214	1771	hg19	N/A	N/A	N/A	Enhatls89430	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	5094				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4350
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1772	hg19	N/A	N/A	N/A	Enhatls89431	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1773	hg19	N/A	enh18006	N/A	Enhatls89431	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1774	hg19	N/A	enh18006	fant56733	Enhatls89431	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1775	hg19	N/A	enh18006	N/A	Enhatls89431	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83381	chr19	30149220	30182121	29658313	29691214	1776	hg19	N/A	N/A	N/A	Enhatls89431	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4351
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1777	hg19	N/A	N/A	N/A	Enhatls89432	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1778	hg19	N/A	enh18007	N/A	Enhatls89432	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	1162				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1779	hg19	N/A	enh18007	fant56734	Enhatls89432	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLEKHF1	chr19	29665458	29675477	5121				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-83382	chr19	30149220	30182121	29658313	29691214	1780	hg19	N/A	enh18007	N/A	Enhatls89432	enhancer	4B	|		|	CACCGATACTGATCCGCGCTAAACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					C19orf12	chr19	29698936	29715789	2069				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4352
enhrx-lit14	chr7	61967557	61970462	62507179	62510084	1781	hg19					enhancer	5A	|		|	CACCGTCTAAATGGACGTTCCACTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit15	chr7	61967557	61970462	62507179	62510084	1782	hg19					enhancer	5B	|		|	CACCGATGGACCTGTTTGAGACCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1783	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	39726				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1784	hg19	N/A	enh20955	fant13556	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	39620				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1785	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	29079				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1786	hg19	N/A	enh20955	fant13557	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28829				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1787	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28495				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1788	hg19	N/A	enh20955	fant13558	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28139				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1789	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	27029				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1790	hg19	N/A	enh20955	fant13559	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	26795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1791	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	24030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1792	hg19	N/A	enh20955	fant13560	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	23618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1793	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	23040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1794	hg19	N/A	enh20955	fant13561	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	22830				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1795	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	20753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1796	hg19	N/A	enh20955	fant13562	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	20410				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1797	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6A	|		|	CACCGCTTGACAGTAAACCCCCGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	11674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1798	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	39726				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1799	hg19	N/A	enh20955	fant13556	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	39620				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1800	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	29079				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1801	hg19	N/A	enh20955	fant13557	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28829				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1802	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28495				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1803	hg19	N/A	enh20955	fant13558	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	28139				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1804	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	27029				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1805	hg19	N/A	enh20955	fant13559	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	26795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1806	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	24030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1807	hg19	N/A	enh20955	fant13560	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	23618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1808	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	23040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1809	hg19	N/A	enh20955	fant13561	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	22830				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1810	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	20753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1811	hg19	N/A	enh20955	fant13562	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	20410				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-119209	chr3	134027079	134056695	134308237	134337853	1812	hg19	N/A	enh20955	N/A	Enhatls127566	enhancer	6B	|		|	CACCGTGCTGACTGAATACGTGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					AMOTL2	chr3	134355346	134375479	11674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7338
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1813	hg19	N/A	enh6552	N/A	Enhatls112624	enhancer	8A	|		|	CACCGAAAGATACGAACCGCTACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	6229				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1814	hg19	N/A	N/A	N/A	Enhatls112624	enhancer	8A	|		|	CACCGAAAGATACGAACCGCTACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	20793				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1815	hg19	N/A	N/A	fant59307	Enhatls112624	enhancer	8A	|		|	CACCGAAAGATACGAACCGCTACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	20990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1816	hg19	N/A	N/A	N/A	Enhatls112624	enhancer	8A	|		|	CACCGAAAGATACGAACCGCTACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	21080				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1817	hg19	N/A	N/A	fant59308	Enhatls112624	enhancer	8A	|		|	CACCGAAAGATACGAACCGCTACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	24180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1818	hg19	N/A	enh6552	N/A	Enhatls112624	enhancer	8B	|		|	CACCGTTTATCTCATCGAAGCGCCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	6229				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1819	hg19	N/A	N/A	N/A	Enhatls112624	enhancer	8B	|		|	CACCGTTTATCTCATCGAAGCGCCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	20793				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1820	hg19	N/A	N/A	fant59307	Enhatls112624	enhancer	8B	|		|	CACCGTTTATCTCATCGAAGCGCCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	20990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1821	hg19	N/A	N/A	N/A	Enhatls112624	enhancer	8B	|		|	CACCGTTTATCTCATCGAAGCGCCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	21080				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55858616	55865992	57283560	57290936	1822	hg19	N/A	N/A	fant59308	Enhatls112624	enhancer	8B	|		|	CACCGTTTATCTCATCGAAGCGCCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BMP7	chr20	57168752	57266641	24180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1823	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	23461				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1824	hg19	N/A	enh2357	fant41744	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	23068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1825	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	22615				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1826	hg19	N/A	enh2357	fant41745	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	22215				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1827	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	21951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1828	hg19	N/A	enh2357	fant41746	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	21035				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1829	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	19418				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1830	hg19	N/A	enh2357	fant41747	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	19225				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1831	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	17050				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1832	hg19	N/A	enh2357	fant41748	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	16648				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1833	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	8985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1834	hg19	N/A	N/A	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	7855				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1835	hg19	N/A	enh14725	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	5069				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1836	hg19	N/A	enh14725	fant41749	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	4770				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1837	hg19	N/A	enh14725	N/A	Enhatls41649	enhancer	9A	|		|	CACCGTCATCTCAGCCGGTCGCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	1125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1838	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	23461				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1839	hg19	N/A	enh2357	fant41744	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	23068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1840	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	22615				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1841	hg19	N/A	enh2357	fant41745	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	22215				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1842	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	21951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1843	hg19	N/A	enh2357	fant41746	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	21035				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1844	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	19418				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1845	hg19	N/A	enh2357	fant41747	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	19225				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1846	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	17050				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1847	hg19	N/A	enh2357	fant41748	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	16648				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1848	hg19	N/A	enh2357	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	8985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1849	hg19	N/A	N/A	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	7855				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1850	hg19	N/A	enh14725	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	5069				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1851	hg19	N/A	enh14725	fant41749	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	4770				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-38482	chr12	52538601	52558687	52144817	52164903	1852	hg19	N/A	enh14725	N/A	Enhatls41649	enhancer	9B	|		|	CACCGAATTTAGCGGCCTGTGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KRT80	chr12	52168995	52192014	1125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3792
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1853	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1854	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1855	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1856	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1857	hg19	N/A	enh19572	N/A	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1858	hg19	N/A	enh19572	fant58350	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1859	hg19	N/A	enh19572	N/A	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1860	hg19	hs480	enh19572	N/A	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1861	hg19	hs480	enh19572	fant58351	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	740				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1862	hg19	hs480	enh19572	N/A	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	532				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1863	hg19	N/A	enh19572	N/A	N/A	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1864	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1865	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1866	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1867	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1868	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1869	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1870	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1871	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	10A	|		|	CACCGTGTTTCGGTAGTGTGCGCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1872	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1873	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1874	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103156	chr20	30176094	30200994	31588291	31613191	1875	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1584
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1876	hg19	N/A	enh19572	N/A	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1877	hg19	N/A	enh19572	fant58350	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1878	hg19	N/A	enh19572	N/A	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1879	hg19	hs480	enh19572	N/A	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1880	hg19	hs480	enh19572	fant58351	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	740				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1881	hg19	hs480	enh19572	N/A	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	532				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1882	hg19	N/A	enh19572	N/A	N/A	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1883	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1884	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1885	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1886	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1887	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1888	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1889	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-103157	chr20	30176094	30200994	31588291	31613191	1890	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	10B	|		|	CACCGTATACTAGGAACCGGGCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1585
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1891	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12A	|		|	CACCGTGTGGTGTGGCGACGCCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	7082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1892	hg19	N/A	enh5076	fant56739	Enhatls89444	enhancer	12A	|		|	CACCGTGTGGTGTGGCGACGCCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	19509				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1893	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12A	|		|	CACCGTGTGGTGTGGCGACGCCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	19786				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1894	hg19	N/A	enh5076	fant56740	Enhatls89444	enhancer	12A	|		|	CACCGTGTGGTGTGGCGACGCCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	21363				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1895	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12A	|		|	CACCGTGTGGTGTGGCGACGCCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	21606				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1896	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12B	|		|	CACCGTGCGCGGGGGCGTAAAAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	7082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1897	hg19	N/A	enh5076	fant56739	Enhatls89444	enhancer	12B	|		|	CACCGTGCGCGGGGGCGTAAAAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	19509				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1898	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12B	|		|	CACCGTGCGCGGGGGCGTAAAAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	19786				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1899	hg19	N/A	enh5076	fant56740	Enhatls89444	enhancer	12B	|		|	CACCGTGCGCGGGGGCGTAAAAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	21363				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-83395	chr19	30323584	30347303	29832677	29856396	1900	hg19	N/A	enh5076	N/A	Enhatls89444	enhancer	12B	|		|	CACCGTGCGCGGGGGCGTAAAAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCNE1	chr19	29811990	29824312	21606				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4365
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1901	hg19	N/A	enh14074	N/A	Enhatls33851	enhancer	13A	|		|	CACCGTCCCAGGTAAGTATGACGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	584				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1902	hg19	N/A	enh14074	fant39211	Enhatls33851	enhancer	13A	|		|	CACCGTCCCAGGTAAGTATGACGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	6906				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1903	hg19	N/A	enh14074	N/A	Enhatls33851	enhancer	13A	|		|	CACCGTCCCAGGTAAGTATGACGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	5508				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1904	hg19	N/A	N/A	N/A	Enhatls33851	enhancer	13A	|		|	CACCGTCCCAGGTAAGTATGACGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	5003				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1905	hg19	N/A	enh14074	N/A	Enhatls33851	enhancer	13B	|		|	CACCGCTCCAGCTGTCATCGGTTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	584				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1906	hg19	N/A	enh14074	fant39211	Enhatls33851	enhancer	13B	|		|	CACCGCTCCAGCTGTCATCGGTTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	6906				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1907	hg19	N/A	enh14074	N/A	Enhatls33851	enhancer	13B	|		|	CACCGCTCCAGCTGTCATCGGTTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	5508				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-31143	chr11	72959668	72970895	73248623	73259850	1908	hg19	N/A	N/A	N/A	Enhatls33851	enhancer	13B	|		|	CACCGCTCCAGCTGTCATCGGTTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY6	chr11	73264497	73305103	5003				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5812
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1909	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1910	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1911	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1912	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1913	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1914	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1915	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1916	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1917	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14A	|		|	CACCGTGAACGAGAGTGCGCCCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1918	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1919	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1920	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1921	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1922	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1923	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1924	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1925	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-1816	chr1	16493671	16516686	16167176	16190191	1926	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	14B	|		|	CACCGTCGGGGAGTTTCCACTCCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1815
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1927	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	15252				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1928	hg19	N/A	enh17407	fant53960	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	14650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1929	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	13558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1930	hg19	N/A	enh17407	fant53961	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	13362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1931	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	6978				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1932	hg19	N/A	enh17407	fant53962	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	6395				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1933	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5277				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1934	hg19	N/A	enh17407	fant53963	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	4749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1935	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	4082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1936	hg19	N/A	enh17407	fant53964	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3488				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1937	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3317				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1938	hg19	N/A	enh17407	fant53965	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1939	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	1329				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1940	hg19	N/A	enh17407	N/A	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75092	chr17	76337527	76372564	78341446	78376483	1941	hg19	N/A	N/A	fant53966	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	836				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8361
enhrx-75093	chr17	76337527	76372564	78341446	78376483	1942	hg19	N/A	N/A	fant53967	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	1010				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8362
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1943	hg19	N/A	enh17408	N/A	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3658				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1944	hg19	N/A	enh17408	N/A	Enhatls80616	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5003				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1945	hg19	N/A	enh17408	fant53968	Enhatls80616	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5535				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1946	hg19	N/A	enh17408	N/A	Enhatls80616	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1947	hg19	N/A	enh17408	N/A	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	7113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1948	hg19	N/A	enh17408	N/A	Enhatls80617	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	7193				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1949	hg19	N/A	enh17408	N/A	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	8643				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1950	hg19	N/A	enh17408	N/A	Enhatls80618	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	5947				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1951	hg19	N/A	N/A	N/A	Enhatls80618	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	5030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75095	chr17	76337527	76372564	78341446	78376483	1952	hg19	N/A	N/A	fant53969	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	3052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8364
enhrx-75096	chr17	76337527	76372564	78341446	78376483	1953	hg19	N/A	N/A	fant53970	N/A	enhancer	16A	|		|	CACCGCAGCGCCAGCGCCCGAAATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	2444				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8365
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1954	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	15252				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1955	hg19	N/A	enh17407	fant53960	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	14650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1956	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	13558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1957	hg19	N/A	enh17407	fant53961	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	13362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1958	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	6978				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1959	hg19	N/A	enh17407	fant53962	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	6395				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1960	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5277				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1961	hg19	N/A	enh17407	fant53963	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	4749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1962	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	4082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1963	hg19	N/A	enh17407	fant53964	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3488				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1964	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3317				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1965	hg19	N/A	enh17407	fant53965	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1966	hg19	N/A	enh17407	N/A	Enhatls80615	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	1329				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75091	chr17	76337527	76372564	78341446	78376483	1967	hg19	N/A	enh17407	N/A	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8360
enhrx-75092	chr17	76337527	76372564	78341446	78376483	1968	hg19	N/A	N/A	fant53966	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	836				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8361
enhrx-75093	chr17	76337527	76372564	78341446	78376483	1969	hg19	N/A	N/A	fant53967	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	1010				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8362
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1970	hg19	N/A	enh17408	N/A	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	3658				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1971	hg19	N/A	enh17408	N/A	Enhatls80616	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5003				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1972	hg19	N/A	enh17408	fant53968	Enhatls80616	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5535				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1973	hg19	N/A	enh17408	N/A	Enhatls80616	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	5990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1974	hg19	N/A	enh17408	N/A	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	7113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1975	hg19	N/A	enh17408	N/A	Enhatls80617	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	7193				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1976	hg19	N/A	enh17408	N/A	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SOCS3	chr17	78356777	78360077	8643				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1977	hg19	N/A	enh17408	N/A	Enhatls80618	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	5947				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75094	chr17	76337527	76372564	78341446	78376483	1978	hg19	N/A	N/A	N/A	Enhatls80618	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	5030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8363
enhrx-75095	chr17	76337527	76372564	78341446	78376483	1979	hg19	N/A	N/A	fant53969	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	3052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8364
enhrx-75096	chr17	76337527	76372564	78341446	78376483	1980	hg19	N/A	N/A	fant53970	N/A	enhancer	16B	|		|	CACCGAATGTCCGCGCCGAGTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PGS1	chr17	78378648	78424659	2444				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8365
enhrx-71637	chr17	41740520	41755489	43663152	43678121	1981	hg19	N/A	enh17176	N/A	N/A	enhancer	17A	|		|	CACCGAACAAATGGGTTGCCGTGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MEOX1	chr17	43640388	43661922	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4906
enhrx-71637	chr17	41740520	41755489	43663152	43678121	1982	hg19	N/A	enh17176	N/A	Enhatls76879	enhancer	17A	|		|	CACCGAACAAATGGGTTGCCGTGAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MEOX1	chr17	43640388	43661922	4971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4906
enhrx-71637	chr17	41740520	41755489	43663152	43678121	1983	hg19	N/A	enh17176	N/A	N/A	enhancer	17B	|		|	CACCGTGTGCTGGCCTTCGTCGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MEOX1	chr17	43640388	43661922	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4906
enhrx-71637	chr17	41740520	41755489	43663152	43678121	1984	hg19	N/A	enh17176	N/A	Enhatls76879	enhancer	17B	|		|	CACCGTGTGCTGGCCTTCGTCGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MEOX1	chr17	43640388	43661922	4971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4906
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1985	hg19	N/A	enh14596	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	9417				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1986	hg19	N/A	enh14596	fant41285	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	21642				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1987	hg19	N/A	enh14596	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	22220				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1988	hg19	N/A	N/A	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	25963				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1989	hg19	N/A	enh87953	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	26093				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1990	hg19	N/A	enh87953	fant41286	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	29674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1991	hg19	N/A	enh87953	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	29949				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1992	hg19	N/A	N/A	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	31703				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1993	hg19	N/A	enh80119	N/A	Enhatls39864	enhancer	18A	|		|	CACCGCTAAGATGATCGTTCCTGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	37833				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1994	hg19	N/A	enh14596	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	9417				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1995	hg19	N/A	enh14596	fant41285	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	21642				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1996	hg19	N/A	enh14596	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	22220				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1997	hg19	N/A	N/A	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	25963				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1998	hg19	N/A	enh87953	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	26093				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	1999	hg19	N/A	enh87953	fant41286	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	29674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	2000	hg19	N/A	enh87953	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	29949				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	2001	hg19	N/A	N/A	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	31703				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-36777	chr12	26423922	26446328	26270989	26293395	2002	hg19	N/A	enh80119	N/A	Enhatls39864	enhancer	18B	|		|	CACCGCACTGTAGCGACGTGCAAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SSPN	chr12	26121990	26252920	37833				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2087
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2003	hg19	N/A	enh1826	fant38911	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	53438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2004	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	52996				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2005	hg19	N/A	enh1826	fant38912	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	52678				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2006	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	47912				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2007	hg19	N/A	enh1826	fant38913	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	47245				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2008	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	46269				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2009	hg19	N/A	enh1826	fant38914	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	46063				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2010	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	45746				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2011	hg19	N/A	enh1826	fant38915	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	45270				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2012	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	43579				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2013	hg19	N/A	enh1826	fant38916	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	43330				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2014	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	42573				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2015	hg19	N/A	enh1826	fant38917	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	42303				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2016	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	41107				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2017	hg19	N/A	enh1826	fant38918	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	40964				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2018	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	39597				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2019	hg19	N/A	enh1826	fant38919	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	39454				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2020	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	37840				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2021	hg19	hs1759	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	34154				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2022	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19A	|		|	CACCGTGTTCGGTTTGCACTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	33331				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2023	hg19	N/A	enh1826	fant38911	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	53438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2024	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	52996				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2025	hg19	N/A	enh1826	fant38912	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	52678				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2026	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	47912				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2027	hg19	N/A	enh1826	fant38913	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	47245				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2028	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	46269				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2029	hg19	N/A	enh1826	fant38914	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	46063				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2030	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	45746				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2031	hg19	N/A	enh1826	fant38915	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	45270				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2032	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	43579				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2033	hg19	N/A	enh1826	fant38916	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	43330				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2034	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	42573				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2035	hg19	N/A	enh1826	fant38917	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	42303				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2036	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	41107				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2037	hg19	N/A	enh1826	fant38918	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	40964				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2038	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	39597				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2039	hg19	N/A	enh1826	fant38919	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	39454				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2040	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	37840				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2041	hg19	hs1759	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	34154				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-30037	chr11	65238933	65258918	65471462	65491447	2042	hg19	N/A	enh1826	N/A	Enhatls32635	enhancer	19B	|		|	CACCGCTGCGCTGAGTACCGAAAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCYL1	chr11	65525076	65538704	33331				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4706
enhrx-84749	chr19	40668470	40691123	40162563	40185216	2043	hg19	N/A	enh76138	N/A	Enhatls90853	enhancer	20A	|		|	CACCGGAACTACGATTTGACACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MAP3K10	chr19	40191425	40215575	23598				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5719
enhrx-84749	chr19	40668470	40691123	40162563	40185216	2044	hg19	N/A	N/A	N/A	Enhatls90853	enhancer	20A	|		|	CACCGGAACTACGATTTGACACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MAP3K10	chr19	40191425	40215575	4683				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5719
enhrx-84749	chr19	40668470	40691123	40162563	40185216	2045	hg19	N/A	enh76138	N/A	Enhatls90853	enhancer	20B	|		|	CACCGAAATCGCCTTTGAACGTGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MAP3K10	chr19	40191425	40215575	23598				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5719
enhrx-84749	chr19	40668470	40691123	40162563	40185216	2046	hg19	N/A	N/A	N/A	Enhatls90853	enhancer	20B	|		|	CACCGAAATCGCCTTTGAACGTGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MAP3K10	chr19	40191425	40215575	4683				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5719
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2047	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	16941				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2048	hg19	N/A	enh19713	fant59013	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28281				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2049	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28592				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2050	hg19	N/A	enh19713	fant59014	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28809				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2051	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	29370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2052	hg19	N/A	enh19713	fant59015	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	31880				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2053	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	32516				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2054	hg19	N/A	enh19713	fant59016	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	33751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2055	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	34292				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2056	hg19	N/A	N/A	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	39001				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2057	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	39721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2058	hg19	N/A	enh19714	fant59017	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	54345				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2059	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	54390				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2060	hg19	N/A	enh19714	fant59018	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	55811				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2061	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	55977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2062	hg19	N/A	enh19714	fant59019	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	59553				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2063	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	59857				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2064	hg19	N/A	enh19714	fant59020	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	60108				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2065	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	60487				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2066	hg19	N/A	enh19714	fant59021	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	67097				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2067	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21A	|		|	CACCGCAGCACGATTCACCCTTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	68275				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2068	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	16941				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2069	hg19	N/A	enh19713	fant59013	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28281				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2070	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28592				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2071	hg19	N/A	enh19713	fant59014	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	28809				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2072	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	29370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2073	hg19	N/A	enh19713	fant59015	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	31880				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2074	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	32516				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2075	hg19	N/A	enh19713	fant59016	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	33751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2076	hg19	N/A	enh19713	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	34292				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2077	hg19	N/A	N/A	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	39001				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2078	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	39721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2079	hg19	N/A	enh19714	fant59017	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	54345				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2080	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	54390				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2081	hg19	N/A	enh19714	fant59018	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	55811				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2082	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	55977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2083	hg19	N/A	enh19714	fant59019	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	59553				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2084	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	59857				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2085	hg19	N/A	enh19714	fant59020	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	60108				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2086	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	60487				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2087	hg19	N/A	enh19714	fant59021	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	67097				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-105096	chr20	48833271	48877552	50216734	50261015	2088	hg19	N/A	enh19714	N/A	Enhatls112385	enhancer	21B	|		|	CACCGCCGCCGACCACAAGCGGGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CEBPB	chr20	50190829	50192668	68275				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3524
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2089	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	9426				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2090	hg19	N/A	enh8799	fant20361	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	11622				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2091	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	11735				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2092	hg19	N/A	enh8799	fant20362	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	15905				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2093	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	12712				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2094	hg19	N/A	enh8799	fant20363	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	12639				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2095	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	11693				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2096	hg19	N/A	enh8799	fant20364	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	11406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2097	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	10311				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2098	hg19	N/A	enh8799	N/A	N/A	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	10061				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2099	hg19	N/A	enh8799	N/A	Enhatls146058	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	5835				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2100	hg19	N/A	N/A	N/A	Enhatls146058	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	876				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2101	hg19	N/A	enh8800	N/A	Enhatls146058	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	591				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2102	hg19	N/A	enh8800	N/A	N/A	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2103	hg19	N/A	enh8800	N/A	Enhatls146059	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2104	hg19	N/A	enh8800	N/A	N/A	enhancer	22A	|		|	CACCGCTTAGGTACCAGGACATTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2105	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	9426				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2106	hg19	N/A	enh8799	fant20361	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	11622				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2107	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RPS14	chr5	150442634	150449739	11735				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2108	hg19	N/A	enh8799	fant20362	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	15905				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2109	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	12712				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2110	hg19	N/A	enh8799	fant20363	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	12639				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2111	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	11693				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2112	hg19	N/A	enh8799	fant20364	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	11406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2113	hg19	N/A	enh8799	N/A	Enhatls146057	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	10311				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2114	hg19	N/A	enh8799	N/A	N/A	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	10061				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2115	hg19	N/A	enh8799	N/A	Enhatls146058	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	5835				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2116	hg19	N/A	N/A	N/A	Enhatls146058	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	876				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2117	hg19	N/A	enh8800	N/A	Enhatls146058	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	591				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2118	hg19	N/A	enh8800	N/A	N/A	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2119	hg19	N/A	enh8800	N/A	Enhatls146059	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-136692	chr5	149838733	149869230	150459170	150489667	2120	hg19	N/A	enh8800	N/A	N/A	enhancer	22B	|		|	CACCGGACCACCGCTGCTTACGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDST1	chr5	150485817	150558211	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6483
enhrx-105309	chr20	55891794	55902685	57316738	57327629	2121	hg19	N/A	enh6553	N/A	Enhatls112624	enhancer	23A	|		|	CACCGCTGCTTGTTAGCACGCAGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	8769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55891794	55902685	57316738	57327629	2122	hg19	N/A	enh6553	N/A	N/A	enhancer	23A	|		|	CACCGCTGCTTGTTAGCACGCAGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	5064				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105310	chr20	55891794	55902685	57316738	57327629	2123	hg19	N/A	N/A	N/A	Enhatls112625	enhancer	23A	|		|	CACCGCTGCTTGTTAGCACGCAGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	2659				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3738
enhrx-105309	chr20	55891794	55902685	57316738	57327629	2124	hg19	N/A	enh6553	N/A	Enhatls112624	enhancer	23B	|		|	CACCGACCGGCTAGTAGGGTTTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	8769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105309	chr20	55891794	55902685	57316738	57327629	2125	hg19	N/A	enh6553	N/A	N/A	enhancer	23B	|		|	CACCGACCGGCTAGTAGGGTTTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	5064				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3737
enhrx-105310	chr20	55891794	55902685	57316738	57327629	2126	hg19	N/A	N/A	N/A	Enhatls112625	enhancer	23B	|		|	CACCGACCGGCTAGTAGGGTTTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPO11	chr20	57329802	57343994	2659				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3738
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2127	hg19	N/A	enh1873	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FCHSD2	chr11	72836744	73142318	15768				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2128	hg19	N/A	N/A	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	37401				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2129	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24376				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2130	hg19	N/A	enh1874	fant39204	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24056				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2131	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	23544				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2132	hg19	N/A	enh1874	fant39205	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	23447				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2133	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	22929				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2134	hg19	N/A	enh1874	fant39206	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	22666				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2135	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2136	hg19	N/A	enh1874	fant39207	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19374				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2137	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	13502				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2138	hg19	N/A	enh1874	fant39208	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	13098				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2139	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	12503				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2140	hg19	N/A	enh1874	fant39209	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	12294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2141	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	9231				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2142	hg19	N/A	N/A	N/A	Enhatls33848	enhancer	24A	|		|	CACCGTGAGGTAGCGAAGTATGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	4986				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2143	hg19	N/A	enh1873	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FCHSD2	chr11	72836744	73142318	15768				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2144	hg19	N/A	N/A	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	37401				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2145	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24376				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2146	hg19	N/A	enh1874	fant39204	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24056				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2147	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	23544				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2148	hg19	N/A	enh1874	fant39205	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	23447				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2149	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	22929				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2150	hg19	N/A	enh1874	fant39206	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	22666				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2151	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2152	hg19	N/A	enh1874	fant39207	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19374				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2153	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	13502				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2154	hg19	N/A	enh1874	fant39208	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	13098				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2155	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	12503				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2156	hg19	N/A	enh1874	fant39209	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	12294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2157	hg19	N/A	enh1874	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	9231				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-31140	chr11	72888842	72925604	73177797	73214559	2158	hg19	N/A	N/A	N/A	Enhatls33848	enhancer	24B	|		|	CACCGTTGGGTTCACCCACTCTAG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P2RY2	chr11	73218280	73242427	4986				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5809
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2159	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	2722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2160	hg19	N/A	enh20125	fant60995	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	4543				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2161	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	5177				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2162	hg19	N/A	enh20125	fant60996	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	6761				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2163	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	7059				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2164	hg19	N/A	enh20125	fant60997	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	11060				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2165	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	11188				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2166	hg19	N/A	enh20125	fant60998	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	13997				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2167	hg19	N/A	N/A	fant60998	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	14192				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2168	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	14513				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2169	hg19	N/A	N/A	fant60999	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	15270				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2170	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	15672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2171	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	16302				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2172	hg19	N/A	enh20126	fant61000	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18222				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2173	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18458				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2174	hg19	N/A	enh20126	fant61001	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2175	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	20481				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2176	hg19	N/A	enh20126	fant61002	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	25486				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2177	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	25672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2178	hg19	N/A	enh20126	fant61003	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	28456				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2179	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	29036				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2180	hg19	N/A	enh20126	fant61004	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	31167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2181	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	30235				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2182	hg19	N/A	enh20126	fant61005	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	29492				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2183	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	27903				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2184	hg19	N/A	enh20126	fant61006	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	27336				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2185	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	23703				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2186	hg19	N/A	enh20126	fant61007	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	23448				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2187	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	22744				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2188	hg19	N/A	enh20126	fant61008	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	22284				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2189	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	21226				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2190	hg19	N/A	enh20126	fant61009	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	20837				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2191	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	16231				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2192	hg19	N/A	enh20126	fant61010	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	15875				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2193	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	14480				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2194	hg19	N/A	enh20126	fant61011	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	14250				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2195	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5630				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2196	hg19	N/A	enh20126	fant61012	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4859				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2197	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4734				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2198	hg19	N/A	enh20126	fant61013	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4088				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2199	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	2439				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2200	hg19	N/A	enh20126	fant61014	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	2102				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2201	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1968				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2202	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1750				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2203	hg19	N/A	N/A	fant61015	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1633				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2204	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	12				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109571	chr22	30577358	30650297	30181369	30254308	2205	hg19	N/A	N/A	N/A	Enhatls117250	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1402
enhrx-109572	chr22	30577358	30650297	30181369	30254308	2206	hg19	N/A	N/A	N/A	Enhatls117251	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1403
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2207	hg19	N/A	N/A	fant61016	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2208	hg19	N/A	enh95085	fant61016	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2209	hg19	N/A	enh95085	N/A	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1766				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2210	hg19	N/A	enh95085	fant61017	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	3735				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2211	hg19	N/A	enh95085	N/A	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4475				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2212	hg19	N/A	enh95085	fant61018	N/A	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4919				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2213	hg19	N/A	enh95085	fant61018	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5093				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2214	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5335				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2215	hg19	N/A	enh95085	fant61019	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5645				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2216	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2217	hg19	N/A	enh95085	fant61020	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6202				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2218	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25A	|		|	CACCGAGCAGATGGTTCGGTCAGAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6911				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2219	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	2722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2220	hg19	N/A	enh20125	fant60995	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	4543				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2221	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	5177				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2222	hg19	N/A	enh20125	fant60996	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	6761				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2223	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	7059				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2224	hg19	N/A	enh20125	fant60997	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	11060				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2225	hg19	N/A	enh20125	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	11188				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2226	hg19	N/A	enh20125	fant60998	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	13997				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2227	hg19	N/A	N/A	fant60998	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	14192				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2228	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	14513				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2229	hg19	N/A	N/A	fant60999	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	15270				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2230	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	15672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2231	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	16302				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2232	hg19	N/A	enh20126	fant61000	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18222				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2233	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18458				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2234	hg19	N/A	enh20126	fant61001	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	18722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2235	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	20481				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2236	hg19	N/A	enh20126	fant61002	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	25486				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2237	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	25672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2238	hg19	N/A	enh20126	fant61003	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	28456				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2239	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HORMAD2	chr22	30080463	30177075	29036				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2240	hg19	N/A	enh20126	fant61004	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	31167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2241	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	30235				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2242	hg19	N/A	enh20126	fant61005	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	29492				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2243	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	27903				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2244	hg19	N/A	enh20126	fant61006	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	27336				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2245	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	23703				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2246	hg19	N/A	enh20126	fant61007	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	23448				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2247	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	22744				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2248	hg19	N/A	enh20126	fant61008	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	22284				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2249	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	21226				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2250	hg19	N/A	enh20126	fant61009	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	20837				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2251	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	16231				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2252	hg19	N/A	enh20126	fant61010	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	15875				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2253	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	14480				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2254	hg19	N/A	enh20126	fant61011	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	14250				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2255	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5630				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2256	hg19	N/A	enh20126	fant61012	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4859				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2257	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4734				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2258	hg19	N/A	enh20126	fant61013	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4088				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2259	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	2439				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2260	hg19	N/A	enh20126	fant61014	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	2102				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2261	hg19	N/A	enh20126	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1968				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2262	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1750				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2263	hg19	N/A	N/A	fant61015	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1633				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109570	chr22	30577358	30650297	30181369	30254308	2264	hg19	N/A	N/A	N/A	Enhatls117249	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	12				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1401
enhrx-109571	chr22	30577358	30650297	30181369	30254308	2265	hg19	N/A	N/A	N/A	Enhatls117250	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1402
enhrx-109572	chr22	30577358	30650297	30181369	30254308	2266	hg19	N/A	N/A	N/A	Enhatls117251	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1403
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2267	hg19	N/A	N/A	fant61016	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2268	hg19	N/A	enh95085	fant61016	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2269	hg19	N/A	enh95085	N/A	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	1766				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2270	hg19	N/A	enh95085	fant61017	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	3735				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2271	hg19	N/A	enh95085	N/A	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4475				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2272	hg19	N/A	enh95085	fant61018	N/A	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	4919				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2273	hg19	N/A	enh95085	fant61018	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5093				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2274	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5335				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2275	hg19	N/A	enh95085	fant61019	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	5645				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2276	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2277	hg19	N/A	enh95085	fant61020	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6202				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-109573	chr22	30577358	30650297	30181369	30254308	2278	hg19	N/A	enh95085	N/A	Enhatls117252	enhancer	25B	|		|	CACCGCCAGAGACTGGATCCGGTAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LIF	chr22	30240452	30246759	6911				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1404
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2279	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2280	hg19	N/A	enh17263	fant53208	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	3283				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2281	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	4809				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2282	hg19	N/A	enh17263	fant53209	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	5570				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2283	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	5814				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2284	hg19	N/A	enh17263	fant53210	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	7575				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2285	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	6214				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2286	hg19	N/A	enh17263	fant53211	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	5814				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2287	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	4390				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2288	hg19	N/A	enh17263	fant53212	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	4042				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2289	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	3858				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2290	hg19	N/A	enh17263	fant53213	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	3495				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2291	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26A	|		|	CACCGCGGGAGCTAATCTTGATTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	2623				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2292	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2293	hg19	N/A	enh17263	fant53208	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	3283				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2294	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	4809				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2295	hg19	N/A	enh17263	fant53209	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	5570				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2296	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					VMP1	chr17	59707516	59842255	5814				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2297	hg19	N/A	enh17263	fant53210	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	7575				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2298	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	6214				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2299	hg19	N/A	enh17263	fant53211	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	5814				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2300	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	4390				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2301	hg19	N/A	enh17263	fant53212	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	4042				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2302	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	3858				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2303	hg19	N/A	enh17263	fant53213	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	3495				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-73201	chr17	57919475	57933964	59842114	59856603	2304	hg19	N/A	enh17263	N/A	Enhatls78584	enhancer	26B	|		|	CACCGATGGATCCCTCCTATCGGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TUBD1	chr17	59859478	59892945	2623				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6470
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2305	hg19	N/A	N/A	N/A	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	5040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2306	hg19	N/A	enh90200	N/A	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	5285				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2307	hg19	N/A	enh90200	fant13359	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	7486				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2308	hg19	N/A	enh90200	N/A	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	7871				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2309	hg19	N/A	N/A	N/A	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	10161				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2310	hg19	N/A	enh20886	N/A	Enhatls126718	enhancer	28A	|		|	CACCGTTCTAGTGCACTAGACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	10985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2311	hg19	N/A	N/A	N/A	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	5040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2312	hg19	N/A	enh90200	N/A	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	5285				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2313	hg19	N/A	enh90200	fant13359	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	7486				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2314	hg19	N/A	enh90200	N/A	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	7871				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2315	hg19	N/A	N/A	N/A	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	10161				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-118420	chr3	125314931	125328711	125596087	125609867	2316	hg19	N/A	enh20886	N/A	Enhatls126718	enhancer	28B	|		|	CACCGAATTGATACTACTGGGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OSBPL11	chr3	125528857	125595497	10985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6549
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2317	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	10370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2318	hg19	N/A	enh81485	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	19720				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2319	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	23970				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2320	hg19	N/A	enh17907	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	25020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2321	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	36310				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2322	hg19	N/A	enh17908	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	22852				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2323	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	18892				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2324	hg19	N/A	enh17909	N/A	Enhatls86881	enhancer	29A	|		|	CACCGTGTGGTGCACGTCGTAGATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	5002				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2325	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	10370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2326	hg19	N/A	enh81485	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	19720				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2327	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	23970				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2328	hg19	N/A	enh17907	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	25020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2329	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MUC16	chr19	8848843	9010390	36310				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2330	hg19	N/A	enh17908	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	22852				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2331	hg19	N/A	N/A	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	18892				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-81008	chr19	9136459	9190714	9025783	9080038	2332	hg19	N/A	enh17909	N/A	Enhatls86881	enhancer	29B	|		|	CACCGGTGCTCCAATCACGGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR1M1	chr19	9087060	9095669	5002				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1978
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2333	hg19	N/A	enh22206	N/A	Enhatls140964	enhancer	30A	|		|	CACCGCCACAATAATGATAATCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCL28	chr5	43379192	43412391	5977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2334	hg19	N/A	enh22206	fant18417	Enhatls140964	enhancer	30A	|		|	CACCGCCACAATAATGATAATCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM267	chr5	43444251	43483891	15335				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2335	hg19	N/A	enh22206	N/A	Enhatls140964	enhancer	30A	|		|	CACCGCCACAATAATGATAATCGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM267	chr5	43444251	43483891	8595				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2336	hg19	N/A	enh22206	N/A	Enhatls140964	enhancer	30B	|		|	CACCGTGGGAGCCGTAGCTCCGTCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCL28	chr5	43379192	43412391	5977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2337	hg19	N/A	enh22206	fant18417	Enhatls140964	enhancer	30B	|		|	CACCGTGGGAGCCGTAGCTCCGTCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM267	chr5	43444251	43483891	15335				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-131882	chr5	43421029	43434897	43420927	43434795	2338	hg19	N/A	enh22206	N/A	Enhatls140964	enhancer	30B	|		|	CACCGTGGGAGCCGTAGCTCCGTCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM267	chr5	43444251	43483891	8595				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1673
enhrx-36900	chr12	27666670	27671214	27513737	27518281	2339	hg19	N/A	enh14602	N/A	Enhatls39992	enhancer	31A	|		|	CACCGTTAAGCGCTTTCAAGTCGTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PPFIBP1	chr12	27523430	27695564	5529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2210
enhrx-36900	chr12	27666670	27671214	27513737	27518281	2340	hg19	N/A	N/A	N/A	Enhatls39992	enhancer	31A	|		|	CACCGTTAAGCGCTTTCAAGTCGTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PPFIBP1	chr12	27523430	27695564	4324				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2210
enhrx-36900	chr12	27666670	27671214	27513737	27518281	2341	hg19	N/A	enh14602	N/A	Enhatls39992	enhancer	31B	|		|	CACCGTCAAGCCGTTTAGGATCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PPFIBP1	chr12	27523430	27695564	5529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2210
enhrx-36900	chr12	27666670	27671214	27513737	27518281	2342	hg19	N/A	N/A	N/A	Enhatls39992	enhancer	31B	|		|	CACCGTCAAGCCGTTTAGGATCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PPFIBP1	chr12	27523430	27695564	4324				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2210
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2343	hg19	N/A	enh48528	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	31951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2344	hg19	N/A	enh48528	fant58972	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	36594				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2345	hg19	N/A	enh48528	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	36985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2346	hg19	N/A	N/A	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	40541				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2347	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	42751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2348	hg19	N/A	enh19701	fant58973	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	47180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2349	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	45585				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2350	hg19	N/A	enh19701	fant58974	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	45301				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2351	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	44509				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2352	hg19	N/A	enh19701	fant58975	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	44020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2353	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	40439				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2354	hg19	N/A	enh19701	fant58976	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	39902				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2355	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	37578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2356	hg19	N/A	enh19701	fant58977	Enhatls112337	enhancer	32A	|		|	CACCGACAGGCTGACTTACGTAACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	36930				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2357	hg19	N/A	enh48528	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	31951				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2358	hg19	N/A	enh48528	fant58972	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	36594				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2359	hg19	N/A	enh48528	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	36985				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2360	hg19	N/A	N/A	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	40541				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2361	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					B4GALT5	chr20	49632944	49713878	42751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2362	hg19	N/A	enh19701	fant58973	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	47180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2363	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	45585				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2364	hg19	N/A	enh19701	fant58974	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	45301				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2365	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	44509				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2366	hg19	N/A	enh19701	fant58975	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	44020				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2367	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	40439				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2368	hg19	N/A	enh19701	fant58976	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	39902				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2369	hg19	N/A	enh19701	N/A	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	37578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-105062	chr20	48363867	48392036	49747330	49775499	2370	hg19	N/A	enh19701	fant58977	Enhatls112337	enhancer	32B	|		|	CACCGAACCACCCCTACCGCTTAGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC9A8	chr20	49812712	49892242	36930				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3490
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2371	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	28462				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2372	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	28204				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2373	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	27928				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2374	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	27644				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2375	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	25199				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2376	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	24794				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2377	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	15910				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2378	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	14749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2379	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	33A	|		|	CACCGAAACCCCCCTGTGATACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	5764				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2380	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	28462				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2381	hg19	N/A	enh32225	fant52964	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	28204				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2382	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	27928				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2383	hg19	N/A	enh32225	fant52965	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	27644				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2384	hg19	N/A	enh32225	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	25199				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2385	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	24794				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2386	hg19	N/A	enh62625	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	15910				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2387	hg19	N/A	N/A	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	14749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-72480	chr17	48104382	48125378	50027018	50048014	2388	hg19	N/A	enh44446	N/A	Enhatls77794	enhancer	33B	|		|	CACCGAACACTTACGATGTCCCCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ITGA3	chr17	50056109	50090481	5764				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5749
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2389	hg19	N/A	enh15973	N/A	Enhatls57057	enhancer	36A	|		|	CACCGTCGCAAGAGTTTACGGTTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	5				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2390	hg19	N/A	N/A	N/A	Enhatls57057	enhancer	36A	|		|	CACCGTCGCAAGAGTTTACGGTTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	9098				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2391	hg19	N/A	enh15974	N/A	Enhatls57057	enhancer	36A	|		|	CACCGTCGCAAGAGTTTACGGTTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	15515				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2392	hg19	N/A	N/A	N/A	Enhatls57057	enhancer	36A	|		|	CACCGTCGCAAGAGTTTACGGTTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	25776				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2393	hg19	N/A	enh15973	N/A	Enhatls57057	enhancer	36B	|		|	CACCGAACACTAGAGCATGCGGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	5				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2394	hg19	N/A	N/A	N/A	Enhatls57057	enhancer	36B	|		|	CACCGAACACTAGAGCATGCGGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	9098				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2395	hg19	N/A	enh15974	N/A	Enhatls57057	enhancer	36B	|		|	CACCGAACACTAGAGCATGCGGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	15515				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-52910	chr14	103604163	103638501	103137826	103172164	2396	hg19	N/A	N/A	N/A	Enhatls57057	enhancer	36B	|		|	CACCGAACACTAGAGCATGCGGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNFAIP2	chr14	103121475	103137439	25776				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4867
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2397	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	102749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2398	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	100751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2399	hg19	N/A	enh63185	fant12894	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	100524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2400	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	98952				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2401	hg19	N/A	enh63185	fant12895	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	98689				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2402	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	95479				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2403	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	88793				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2404	hg19	N/A	enh20791	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	84313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2405	hg19	N/A	enh20791	fant12896	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	84306				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2406	hg19	N/A	enh20791	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	82922				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2407	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	82053				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2408	hg19	N/A	enh20792	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	69863				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2409	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	69373				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2410	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	57546				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2411	hg19	N/A	enh7435	fant12897	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	57269				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2412	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	56068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2413	hg19	N/A	enh7435	fant12898	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	55896				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2414	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	54578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2415	hg19	N/A	enh7435	fant12899	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53981				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2416	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53332				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2417	hg19	N/A	enh7435	fant12900	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53178				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2418	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	50065				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2419	hg19	N/A	enh7435	fant12901	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	49461				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2420	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	48773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2421	hg19	N/A	enh7435	fant12902	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	48677				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2422	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	41602				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2423	hg19	N/A	enh7435	fant12903	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	41391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2424	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	38337				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2425	hg19	N/A	enh7435	fant12904	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	38131				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2426	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	36835				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2427	hg19	N/A	enh7435	fant12905	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	36779				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2428	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	34062				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2429	hg19	N/A	enh7435	fant12906	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	33853				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2430	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	30823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2431	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	26393				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2432	hg19	N/A	enh20793	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	16323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2433	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	16073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2434	hg19	N/A	enh7436	N/A	Enhatls125432	enhancer	38A	|		|	CACCGTTGGCTATGGACAAACGGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	423				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2435	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	102749				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2436	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	100751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2437	hg19	N/A	enh63185	fant12894	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	100524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2438	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	98952				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2439	hg19	N/A	enh63185	fant12895	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	98689				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2440	hg19	N/A	enh63185	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	95479				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2441	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	88793				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2442	hg19	N/A	enh20791	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	84313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2443	hg19	N/A	enh20791	fant12896	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	84306				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2444	hg19	N/A	enh20791	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	82922				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2445	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	82053				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2446	hg19	N/A	enh20792	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	69863				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2447	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	69373				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2448	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	57546				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2449	hg19	N/A	enh7435	fant12897	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	57269				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2450	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	56068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2451	hg19	N/A	enh7435	fant12898	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	55896				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2452	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	54578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2453	hg19	N/A	enh7435	fant12899	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53981				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2454	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53332				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2455	hg19	N/A	enh7435	fant12900	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	53178				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2456	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	50065				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2457	hg19	N/A	enh7435	fant12901	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	49461				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2458	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	48773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2459	hg19	N/A	enh7435	fant12902	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	48677				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2460	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	41602				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2461	hg19	N/A	enh7435	fant12903	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	41391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2462	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	38337				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2463	hg19	N/A	enh7435	fant12904	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	38131				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2464	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	36835				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2465	hg19	N/A	enh7435	fant12905	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	36779				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2466	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	34062				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2467	hg19	N/A	enh7435	fant12906	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	33853				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2468	hg19	N/A	enh7435	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	30823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2469	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	26393				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2470	hg19	N/A	enh20793	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	16323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2471	hg19	N/A	N/A	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	16073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-117202	chr3	107653709	107761355	107934862	108042508	2472	hg19	N/A	enh7436	N/A	Enhatls125432	enhancer	38B	|		|	CACCGTGATGTATTCGCCGCCTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CD47	chr3	108043090	108091862	423				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5331
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2473	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CAMK2G	chr10	73812500	73874591	5002				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2474	hg19	N/A	enh13305	fant36133	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CAMK2G	chr10	73812500	73874591	14208				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2475	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	14613				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2476	hg19	N/A	enh13305	fant36134	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	14362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2477	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	12313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2478	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	12214				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2479	hg19	N/A	enh13306	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	10099				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2480	hg19	N/A	enh13306	fant36135	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	9808				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2481	hg19	N/A	enh13306	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	6420				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2482	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2483	hg19	N/A	N/A	fant36136	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3282				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2484	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3075				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21311	chr10	75645910	75666957	73886152	73907199	2485	hg19	N/A	N/A	fant36137	N/A	enhancer	39A	|		|	CACCGCACATCCAAATAGCTACGGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	2135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3746
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2486	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CAMK2G	chr10	73812500	73874591	5002				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2487	hg19	N/A	enh13305	fant36133	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CAMK2G	chr10	73812500	73874591	14208				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2488	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	14613				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2489	hg19	N/A	enh13305	fant36134	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	14362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2490	hg19	N/A	enh13305	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	12313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2491	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	12214				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2492	hg19	N/A	enh13306	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	10099				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2493	hg19	N/A	enh13306	fant36135	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	9808				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2494	hg19	N/A	enh13306	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	6420				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2495	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2496	hg19	N/A	N/A	fant36136	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3282				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21310	chr10	75645910	75666957	73886152	73907199	2497	hg19	N/A	N/A	N/A	Enhatls23441	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	3075				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3745
enhrx-21311	chr10	75645910	75666957	73886152	73907199	2498	hg19	N/A	N/A	fant36137	N/A	enhancer	39B	|		|	CACCGACCCAGTTATTACCTAAGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLAU	chr10	73909176	73917496	2135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3746
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2499	hg19	N/A	enh54579	N/A	N/A	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2500	hg19	N/A	enh54579	N/A	Enhatls132077	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2501	hg19	N/A	enh54579	fant15164	Enhatls132077	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2502	hg19	N/A	enh54579	N/A	Enhatls132077	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2503	hg19	N/A	N/A	N/A	Enhatls132077	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2504	hg19	N/A	enh36340	N/A	Enhatls132077	enhancer	41A	|		|	CACCGGCATAAACTCTAAACGTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	6826				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2505	hg19	N/A	enh54579	N/A	N/A	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2506	hg19	N/A	enh54579	N/A	Enhatls132077	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2507	hg19	N/A	enh54579	fant15164	Enhatls132077	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2508	hg19	N/A	enh54579	N/A	Enhatls132077	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2509	hg19	N/A	N/A	N/A	Enhatls132077	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-123414	chr4	10046735	10065982	10045111	10064358	2510	hg19	N/A	enh36340	N/A	Enhatls132077	enhancer	41B	|		|	CACCGTGTATGACCGATTCCATACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC2A9	chr4	9826223	10054936	6826				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	958
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2511	hg19	N/A	N/A	N/A	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNNI1	chr1	201403783	201429866	582				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2512	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	8470				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2513	hg19	N/A	enh875	fant4287	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	8280				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2514	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	7216				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2515	hg19	N/A	enh875	fant4288	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	7033				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2516	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	2416				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2517	hg19	N/A	enh875	fant4289	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	2114				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2518	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42A	|		|	CACCGCAAAGGGTGTAAAGCGGTCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2519	hg19	N/A	N/A	N/A	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNNI1	chr1	201403783	201429866	582				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2520	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	8470				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2521	hg19	N/A	enh875	fant4287	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	8280				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2522	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	7216				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2523	hg19	N/A	enh875	fant4288	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	7033				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2524	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	2416				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2525	hg19	N/A	enh875	fant4289	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	2114				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-14230	chr1	201403674	201432220	201434546	201463092	2526	hg19	N/A	enh875	N/A	Enhatls15660	enhancer	42B	|		|	CACCGATGACTCACGTATCGGGTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PHLDA3	chr1	201464277	201469237	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14229
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2527	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	40060				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2528	hg19	N/A	enh13764	fant37928	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	41601				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2529	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	41866				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2530	hg19	N/A	enh13764	fant37929	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	43995				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2531	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	44286				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2532	hg19	N/A	enh13764	fant37930	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	55296				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2533	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	55547				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2534	hg19	N/A	enh13764	fant37931	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	58010				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2535	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	58298				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2536	hg19	N/A	enh13764	fant37932	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60021				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2537	hg19	N/A	N/A	fant37932	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60147				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2538	hg19	N/A	N/A	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2539	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	64343				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2540	hg19	N/A	enh13765	fant37933	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67681				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2541	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67932				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2542	hg19	N/A	enh13765	fant37934	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67957				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2543	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	68329				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2544	hg19	N/A	enh13765	fant37935	Enhatls29055	enhancer	43A	|		|	CACCGACCGTGGGGCTTACATGCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	73250				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2545	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	40060				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2546	hg19	N/A	enh13764	fant37928	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	41601				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2547	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	41866				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2548	hg19	N/A	enh13764	fant37929	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	43995				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2549	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	44286				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2550	hg19	N/A	enh13764	fant37930	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	55296				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2551	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	55547				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2552	hg19	N/A	enh13764	fant37931	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	58010				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2553	hg19	N/A	enh13764	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	58298				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2554	hg19	N/A	enh13764	fant37932	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60021				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2555	hg19	N/A	N/A	fant37932	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60147				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2556	hg19	N/A	N/A	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	60313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2557	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	64343				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2558	hg19	N/A	enh13765	fant37933	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67681				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2559	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67932				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2560	hg19	N/A	enh13765	fant37934	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	67957				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2561	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	68329				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-26646	chr11	10921481	10953619	10899934	10932072	2562	hg19	N/A	enh13765	fant37935	Enhatls29055	enhancer	43B	|		|	CACCGACGGAGCAGCGCGTAACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZBED5	chr11	10852703	10858796	73250				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1315
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2563	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	19550				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2564	hg19	N/A	enh22960	fant21351	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	23325				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2565	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	23566				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2566	hg19	N/A	enh22960	fant21352	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	27319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2567	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	27569				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2568	hg19	N/A	enh22960	fant21353	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	28878				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2569	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	29096				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2570	hg19	N/A	enh22960	fant21354	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	31925				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2571	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	32425				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2572	hg19	N/A	N/A	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	37294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2573	hg19	N/A	enh22961	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	37394				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2574	hg19	N/A	enh22961	fant21355	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	39420				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2575	hg19	N/A	enh22961	N/A	Enhatls148271	enhancer	44A	|		|	CACCGAGGTGTCTCTTGACGGAACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	39521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2576	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	19550				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2577	hg19	N/A	enh22960	fant21351	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	23325				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2578	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	23566				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2579	hg19	N/A	enh22960	fant21352	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	27319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2580	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	27569				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2581	hg19	N/A	enh22960	fant21353	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	28878				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2582	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	29096				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2583	hg19	N/A	enh22960	fant21354	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	31925				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2584	hg19	N/A	enh22960	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	32425				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2585	hg19	N/A	N/A	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	37294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2586	hg19	N/A	enh22961	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	37394				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2587	hg19	N/A	enh22961	fant21355	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	39420				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6677156	6695575	6676923	6695342	2588	hg19	N/A	enh22961	N/A	Enhatls148271	enhancer	44B	|		|	CACCGCAAATGCGGGTCCGACCTTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	39521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2589	hg19	N/A	enh79232	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	46909				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2590	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	44959				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2591	hg19	N/A	enh61918	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	36769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2592	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	35239				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2593	hg19	N/A	enh12340	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	28229				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2594	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45A	|		|	CACCGCATTCTGACATCGCGATGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	19019				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2595	hg19	N/A	enh79232	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	46909				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2596	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	44959				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2597	hg19	N/A	enh61918	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	36769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2598	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	35239				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2599	hg19	N/A	enh12340	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	28229				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-12046	chr1	165122015	165144300	165152778	165175063	2600	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	45B	|		|	CACCGTACAATGGACAATTAGGCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LMX1A	chr1	165201866	165356715	19019				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	12045
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2601	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	75527				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2602	hg19	N/A	enh2676	fant43560	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	75391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2603	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	63846				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2604	hg19	N/A	enh2676	fant43561	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	62800				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2605	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	59868				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2606	hg19	N/A	enh2676	fant43562	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	59615				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2607	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	56601				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2608	hg19	N/A	enh2676	fant43563	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	56320				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2609	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	55783				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2610	hg19	N/A	enh2676	fant43564	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	55356				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2611	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	49537				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2612	hg19	N/A	enh2676	fant43565	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	49173				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2613	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	42459				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2614	hg19	N/A	enh2676	fant43566	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	42193				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2615	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	39685				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2616	hg19	N/A	enh2676	fant43567	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	39529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2617	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36730				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2618	hg19	N/A	enh2676	fant43568	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36616				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2619	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2620	hg19	N/A	enh2676	fant43569	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	35954				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2621	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	32104				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2622	hg19	N/A	enh2676	fant43570	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	31885				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2623	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	31029				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2624	hg19	N/A	enh2676	fant43571	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	30354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2625	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	29451				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2626	hg19	N/A	enh2676	fant43572	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	29135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2627	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47A	|		|	CACCGCAGTCTACTTTCGATCAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	21798				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2628	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	75527				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2629	hg19	N/A	enh2676	fant43560	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	75391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2630	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	63846				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2631	hg19	N/A	enh2676	fant43561	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	62800				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2632	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	59868				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2633	hg19	N/A	enh2676	fant43562	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	59615				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2634	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	56601				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2635	hg19	N/A	enh2676	fant43563	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	56320				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2636	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	55783				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2637	hg19	N/A	enh2676	fant43564	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	55356				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2638	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	49537				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2639	hg19	N/A	enh2676	fant43565	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	49173				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2640	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	42459				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2641	hg19	N/A	enh2676	fant43566	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	42193				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2642	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	39685				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2643	hg19	N/A	enh2676	fant43567	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	39529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2644	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36730				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2645	hg19	N/A	enh2676	fant43568	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36616				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2646	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	36167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2647	hg19	N/A	enh2676	fant43569	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	35954				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2648	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	32104				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2649	hg19	N/A	enh2676	fant43570	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	31885				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2650	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	31029				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2651	hg19	N/A	enh2676	fant43571	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	30354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2652	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	29451				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2653	hg19	N/A	enh2676	fant43572	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	29135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-43859	chr12	125185845	125232426	124701299	124747880	2654	hg19	N/A	enh2676	N/A	Enhatls47350	enhancer	47B	|		|	CACCGTTAGCTTAAGCTCTCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SCARB1	chr12	124776855	124863921	21798				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9169
enhrx-982	chr1	8949383	8974154	8889324	8914095	2655	hg19	N/A	enh26520	N/A	Enhatls1056	enhancer	48A	|		|	CACCGAGTCCGTGCGTAGGCTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	7981				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2656	hg19	N/A	N/A	N/A	Enhatls1056	enhancer	48A	|		|	CACCGAGTCCGTGCGTAGGCTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	14467				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2657	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	48A	|		|	CACCGAGTCCGTGCGTAGGCTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	15357				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2658	hg19	N/A	enh11478	fant286	Enhatls1056	enhancer	48A	|		|	CACCGAGTCCGTGCGTAGGCTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	24803				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2659	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	48A	|		|	CACCGAGTCCGTGCGTAGGCTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CA6	chr1	8945866	8975092	22851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2660	hg19	N/A	enh26520	N/A	Enhatls1056	enhancer	48B	|		|	CACCGCTGAACTAGGTTTGCGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	7981				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2661	hg19	N/A	N/A	N/A	Enhatls1056	enhancer	48B	|		|	CACCGCTGAACTAGGTTTGCGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	14467				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2662	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	48B	|		|	CACCGCTGAACTAGGTTTGCGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	15357				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2663	hg19	N/A	enh11478	fant286	Enhatls1056	enhancer	48B	|		|	CACCGCTGAACTAGGTTTGCGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ENO1	chr1	8860999	8879190	24803				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-982	chr1	8949383	8974154	8889324	8914095	2664	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	48B	|		|	CACCGCTGAACTAGGTTTGCGCCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CA6	chr1	8945866	8975092	22851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	981
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2665	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	81008				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2666	hg19	N/A	enh1501	fant36995	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	90841				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2667	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	91354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2668	hg19	N/A	enh1501	fant36996	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	94402				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2669	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	89706				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2670	hg19	N/A	enh1501	fant36997	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	89428				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2671	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	88009				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2672	hg19	N/A	enh1501	fant36998	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2673	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87504				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2674	hg19	N/A	enh1501	fant36999	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87127				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2675	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	83518				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2676	hg19	N/A	enh1501	fant37000	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	83142				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2677	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49A	|		|	CACCGAGGTACAGCGACTCGAGCTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	74063				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2678	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	81008				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2679	hg19	N/A	enh1501	fant36995	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	90841				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2680	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	91354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2681	hg19	N/A	enh1501	fant36996	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SMNDC1	chr10	110290729	110304920	94402				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2682	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	89706				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2683	hg19	N/A	enh1501	fant36997	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	89428				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2684	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	88009				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2685	hg19	N/A	enh1501	fant36998	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2686	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87504				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2687	hg19	N/A	enh1501	fant36999	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	87127				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2688	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	83518				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2689	hg19	N/A	enh1501	fant37000	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	83142				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-23737	chr10	112152370	112182969	110392612	110423211	2690	hg19	N/A	enh1501	N/A	Enhatls26055	enhancer	49B	|		|	CACCGAGGTAGCACGTTCACGGCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DUSP5	chr10	110497906	110511533	74063				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6172
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2691	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	6333				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2692	hg19	N/A	enh9787	fant26465	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	9034				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2693	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	9387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2694	hg19	N/A	enh9787	fant26466	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	14040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2695	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	14438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2696	hg19	N/A	enh9787	fant26467	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	18873				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2697	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	19134				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2698	hg19	N/A	enh9787	fant26468	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	19795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2699	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	20041				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2700	hg19	N/A	enh9787	fant26469	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	22319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2701	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	22510				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2702	hg19	N/A	enh9787	fant26470	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	23398				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2703	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50A	|		|	CACCGAAGTGGATCACGTACGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	23530				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2704	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	6333				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2705	hg19	N/A	enh9787	fant26465	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	9034				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2706	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	9387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2707	hg19	N/A	enh9787	fant26466	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	14040				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2708	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	14438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2709	hg19	N/A	enh9787	fant26467	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	18873				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2710	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	19134				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2711	hg19	N/A	enh9787	fant26468	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	19795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2712	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	20041				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2713	hg19	N/A	enh9787	fant26469	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	22319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2714	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	22510				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2715	hg19	N/A	enh9787	fant26470	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	23398				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-149754	chr7	47631136	47646475	47591538	47606877	2716	hg19	N/A	enh9787	N/A	Enhatls160068	enhancer	50B	|		|	CACCGCAGCTCCTTAATCACGTATA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TNS3	chr7	47275153	47582558	23530				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2566
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2717	hg19	N/A	enh34959	N/A	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMPRSS2	chr21	41464299	41531116	94430				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2718	hg19	N/A	enh34959	fant60353	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	98153				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2719	hg19	N/A	enh34959	N/A	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	97313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2720	hg19	N/A	enh34959	fant60354	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	97030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2721	hg19	N/A	enh34959	N/A	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	93594				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107431	chr21	43052090	43080709	41631930	41660549	2722	hg19	N/A	enh19994	N/A	N/A	enhancer	51A	|		|	CACCGTCATAGTGTGTCGTGAGAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	75110				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1314
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2723	hg19	N/A	enh34959	N/A	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMPRSS2	chr21	41464299	41531116	94430				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2724	hg19	N/A	enh34959	fant60353	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	98153				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2725	hg19	N/A	enh34959	N/A	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	97313				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2726	hg19	N/A	enh34959	fant60354	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	97030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107430	chr21	43052090	43080709	41631930	41660549	2727	hg19	N/A	enh34959	N/A	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	93594				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1313
enhrx-107431	chr21	43052090	43080709	41631930	41660549	2728	hg19	N/A	enh19994	N/A	N/A	enhancer	51B	|		|	CACCGCAGACCCGTGTCCCGTGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RIPK4	chr21	41739368	41767089	75110				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1314
enhrx-104075	chr20	36796473	36816181	38168071	38187779	2729	hg19	N/A	N/A	fant58593	N/A	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2503
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2730	hg19	N/A	enh19623	N/A	N/A	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2731	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2732	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2733	hg19	N/A	enh6409	N/A	Enhatls111312	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	11406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2734	hg19	N/A	enh6409	fant58594	Enhatls111312	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	11726				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2735	hg19	N/A	enh6409	N/A	Enhatls111312	enhancer	52A	|		|	CACCGCCTGCAGGCTCCAAATATCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KIAA1755	chr20	38210502	38260772	9052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104075	chr20	36796473	36816181	38168071	38187779	2736	hg19	N/A	N/A	fant58593	N/A	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2503
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2737	hg19	N/A	enh19623	N/A	N/A	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2738	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2739	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2740	hg19	N/A	enh6409	N/A	Enhatls111312	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	11406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2741	hg19	N/A	enh6409	fant58594	Enhatls111312	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TGM2	chr20	38127384	38166578	11726				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-104076	chr20	36796473	36816181	38168071	38187779	2742	hg19	N/A	enh6409	N/A	Enhatls111312	enhancer	52B	|		|	CACCGAAGCAATCTGATTACCGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KIAA1755	chr20	38210502	38260772	9052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2504
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2743	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	99694				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2744	hg19	N/A	enh21134	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	103641				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2745	hg19	N/A	enh21134	fant14294	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	123785				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2746	hg19	N/A	enh21134	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	124145				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2747	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	126728				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2748	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	127207				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2749	hg19	N/A	enh7693	fant14295	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	129466				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2750	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	129755				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2751	hg19	N/A	enh7693	fant14296	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	130387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2752	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	131135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2753	hg19	N/A	enh7693	fant14297	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	131713				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2754	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	132297				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2755	hg19	N/A	enh7693	fant14298	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	133337				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2756	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	133721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2757	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	136839				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2758	hg19	N/A	N/A	fant14299	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	139144				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2759	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	139323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2760	hg19	N/A	enh21135	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	144418				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2761	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	153288				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2762	hg19	N/A	enh59277	N/A	Enhatls129464	enhancer	53A	|		|	CACCGCGCAATCCATCCGGCAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	155830				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2763	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	99694				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2764	hg19	N/A	enh21134	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	103641				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2765	hg19	N/A	enh21134	fant14294	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	123785				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2766	hg19	N/A	enh21134	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	124145				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2767	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	126728				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2768	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	127207				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2769	hg19	N/A	enh7693	fant14295	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	129466				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2770	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	129755				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2771	hg19	N/A	enh7693	fant14296	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	130387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2772	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	131135				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2773	hg19	N/A	enh7693	fant14297	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	131713				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2774	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	132297				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2775	hg19	N/A	enh7693	fant14298	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	133337				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2776	hg19	N/A	enh7693	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	133721				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2777	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	136839				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2778	hg19	N/A	N/A	fant14299	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	139144				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2779	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	139323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2780	hg19	N/A	enh21135	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	144418				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2781	hg19	N/A	N/A	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	153288				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-120987	chr3	177045540	177104878	177327752	177387090	2782	hg19	N/A	enh59277	N/A	Enhatls129464	enhancer	53B	|		|	CACCGCGTCAGCATACTAATAATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TBL1XR1	chr3	177019343	177228000	155830				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9116
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2783	hg19	N/A	enh7822	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	46265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2784	hg19	N/A	enh7822	fant14830	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	46074				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2785	hg19	N/A	enh7822	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	35319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2786	hg19	N/A	N/A	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	32980				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2787	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	21859				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2788	hg19	N/A	enh21298	fant14831	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	21645				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2789	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	19659				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2790	hg19	N/A	enh21298	fant14832	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	19315				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2791	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54A	|		|	CACCGACGTGTCCCGTGCCGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	459				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2792	hg19	N/A	enh7822	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	46265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2793	hg19	N/A	enh7822	fant14830	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	46074				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2794	hg19	N/A	enh7822	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	35319				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2795	hg19	N/A	N/A	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	32980				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2796	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	21859				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2797	hg19	N/A	enh21298	fant14831	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	21645				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2798	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	19659				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2799	hg19	N/A	enh21298	fant14832	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	19315				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-122353	chr3	197182868	197223128	197455997	197496257	2800	hg19	N/A	enh21298	N/A	Enhatls130954	enhancer	54B	|		|	CACCGTAGGTTGAGGAGGTCCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BDH1	chr3	197509782	197573323	459				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	10482
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2801	hg19	N/A	enh12532	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	10				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2802	hg19	N/A	enh12532	fant4327	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	5839				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2803	hg19	N/A	enh12532	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	6191				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2804	hg19	N/A	N/A	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	8777				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2805	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	9955				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2806	hg19	N/A	enh12533	fant4328	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17169				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2807	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17300				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2808	hg19	N/A	enh12533	fant4329	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17574				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2809	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17836				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2810	hg19	N/A	enh12533	fant4330	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	21852				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2811	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	21922				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2812	hg19	N/A	N/A	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	34125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2813	hg19	N/A	enh12534	N/A	Enhatls15738	enhancer	55A	|		|	CACCGGTCACATACCCTAGTATGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	36419				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2814	hg19	N/A	enh12532	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	10				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2815	hg19	N/A	enh12532	fant4327	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	5839				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2816	hg19	N/A	enh12532	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	6191				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2817	hg19	N/A	N/A	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	8777				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2818	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	9955				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2819	hg19	N/A	enh12533	fant4328	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17169				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2820	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17300				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2821	hg19	N/A	enh12533	fant4329	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17574				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2822	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	17836				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2823	hg19	N/A	enh12533	fant4330	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	21852				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2824	hg19	N/A	enh12533	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	21922				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2825	hg19	N/A	N/A	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	34125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-14295	chr1	201987918	202026572	202018790	202057444	2826	hg19	N/A	enh12534	N/A	Enhatls15738	enhancer	55B	|		|	CACCGTATCTTGACCACGCTAAGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ELF3	chr1	202007944	202017183	36419				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	14294
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2827	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	56648				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2828	hg19	N/A	enh38456	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	57961				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2829	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	72953				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2830	hg19	N/A	enh22646	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	74004				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2831	hg19	N/A	enh22646	fant20098	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	73842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2832	hg19	N/A	enh22646	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	68737				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2833	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	67727				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2834	hg19	N/A	enh22647	N/A	Enhatls145467	enhancer	56A	|		|	CACCGCCGCCTGGAAGGTCGACGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	54112				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2835	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	56648				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2836	hg19	N/A	enh38456	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	57961				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2837	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NDFIP1	chr5	142108778	142154440	72953				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2838	hg19	N/A	enh22646	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	74004				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2839	hg19	N/A	enh22646	fant20098	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	73842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2840	hg19	N/A	enh22646	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	68737				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2841	hg19	N/A	N/A	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	67727				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-136167	chr5	141590669	141626470	142211104	142246905	2842	hg19	N/A	enh22647	N/A	Enhatls145467	enhancer	56B	|		|	CACCGTGGCGCATGTAAGGATACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPRY4	chr5	142310426	142325021	54112				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5958
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2843	hg19	N/A	N/A	N/A	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	17637				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2844	hg19	N/A	enh34570	N/A	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	32975				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2845	hg19	N/A	N/A	N/A	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	39565				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2846	hg19	N/A	enh53721	N/A	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	35668				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2847	hg19	N/A	enh53721	fant58100	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	35362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2848	hg19	N/A	enh53721	N/A	Enhatls109732	enhancer	58A	|		|	CACCGGCACACGCCTGCTAACATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	32991				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2849	hg19	N/A	N/A	N/A	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	17637				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2850	hg19	N/A	enh34570	N/A	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	32975				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2851	hg19	N/A	N/A	N/A	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KAT14	chr20	18137227	18188387	39565				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2852	hg19	N/A	enh53721	N/A	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	35668				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2853	hg19	N/A	enh53721	fant58100	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	35362				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-102626	chr20	18200434	18235842	18219790	18255198	2854	hg19	N/A	enh53721	N/A	Enhatls109732	enhancer	58B	|		|	CACCGATACGCCGGGTGATTCACC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF133	chr20	18288282	18316996	32991				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1054
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2855	hg19	N/A	enh34075	N/A	Enhatls104878	enhancer	59A	|		|	CACCGCGAAAACGAACCTTGACTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	10266				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2856	hg19	N/A	enh34075	fant9564	Enhatls104878	enhancer	59A	|		|	CACCGCGAAAACGAACCTTGACTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	10068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2857	hg19	N/A	enh34075	N/A	Enhatls104878	enhancer	59A	|		|	CACCGCGAAAACGAACCTTGACTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	6247				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2858	hg19	N/A	N/A	N/A	Enhatls104878	enhancer	59A	|		|	CACCGCGAAAACGAACCTTGACTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	2632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2859	hg19	N/A	enh34075	N/A	Enhatls104878	enhancer	59B	|		|	CACCGAGCTTTGACAACTGTCGCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	10266				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2860	hg19	N/A	enh34075	fant9564	Enhatls104878	enhancer	59B	|		|	CACCGAGCTTTGACAACTGTCGCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	10068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2861	hg19	N/A	enh34075	N/A	Enhatls104878	enhancer	59B	|		|	CACCGAGCTTTGACAACTGTCGCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	6247				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-98023	chr2	191500662	191513474	190635936	190648748	2862	hg19	N/A	N/A	N/A	Enhatls104878	enhancer	59B	|		|	CACCGAGCTTTGACAACTGTCGCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					NAB1	chr2	190646745	190692766	2632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9949
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2863	hg19	N/A	enh19757	fant59197	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	126554				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2864	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	126931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2865	hg19	N/A	enh19757	fant59198	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	128518				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2866	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	128783				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2867	hg19	N/A	enh19757	fant59199	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	129656				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2868	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60A	|		|	CACCGTTACACAGAAGGCCGTTCAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	129842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2869	hg19	N/A	enh19757	fant59197	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	126554				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2870	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	126931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2871	hg19	N/A	enh19757	fant59198	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	128518				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2872	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	128783				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2873	hg19	N/A	enh19757	fant59199	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	129656				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-105210	chr20	52352051	52368920	53735512	53752381	2874	hg19	N/A	enh19757	N/A	Enhatls112526	enhancer	60B	|		|	CACCGACCTATAAGAACGGAGTGCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF217	chr20	53567070	53608892	129842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3638
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2875	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	45848				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2876	hg19	N/A	enh21982	fant17531	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	45627				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2877	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	37432				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2878	hg19	N/A	enh21982	fant17532	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	37044				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2879	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	35774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2880	hg19	N/A	enh21982	fant17533	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	35563				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2881	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	34773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2882	hg19	N/A	enh21982	fant17534	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	34370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2883	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	30833				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2884	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	24603				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2885	hg19	N/A	enh21983	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	18233				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2886	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	16903				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2887	hg19	N/A	enh21984	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	11653				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2888	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61A	|		|	CACCGCCATTGGTGCCCTACTGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	5008				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2889	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	45848				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2890	hg19	N/A	enh21982	fant17531	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	45627				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2891	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	37432				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2892	hg19	N/A	enh21982	fant17532	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	37044				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2893	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	35774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2894	hg19	N/A	enh21982	fant17533	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	35563				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2895	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	34773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2896	hg19	N/A	enh21982	fant17534	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	34370				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2897	hg19	N/A	enh21982	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	30833				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2898	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	24603				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2899	hg19	N/A	enh21983	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	18233				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2900	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	16903				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2901	hg19	N/A	enh21984	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	11653				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-129886	chr4	184319283	184361351	183398130	183440198	2902	hg19	N/A	N/A	N/A	Enhatls138844	enhancer	61B	|		|	CACCGGGGACTCTCCCCCGACTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDKN2AIP	chr4	183444634	183449064	5008				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7430
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2903	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	112972				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2904	hg19	N/A	enh18604	fant7300	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	116240				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2905	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	116801				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2906	hg19	N/A	enh18604	fant7301	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	118820				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2907	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	119180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2908	hg19	N/A	N/A	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	126202				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2909	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	126352				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2910	hg19	N/A	enh18605	fant7302	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	131083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2911	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	131366				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2912	hg19	N/A	enh18605	fant7303	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	132802				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2913	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62A	|		|	CACCGTTCCTAGGAGCATCGTGTAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	133326				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2914	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	112972				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2915	hg19	N/A	enh18604	fant7300	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	116240				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2916	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	116801				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2917	hg19	N/A	enh18604	fant7301	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	118820				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2918	hg19	N/A	enh18604	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	119180				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2919	hg19	N/A	N/A	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	126202				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2920	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	126352				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2921	hg19	N/A	enh18605	fant7302	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	131083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2922	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	131366				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2923	hg19	N/A	enh18605	fant7303	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	132802				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-91364	chr2	64486614	64504901	64259480	64277767	2924	hg19	N/A	enh18605	N/A	Enhatls97894	enhancer	62B	|		|	CACCGACATACTGGGTCACGCCTCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PELI1	chr2	64092651	64144420	133326				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3290
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2925	hg19	N/A	enh32992	N/A	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	14307				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2926	hg19	N/A	enh32992	fant5675	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	14011				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2927	hg19	N/A	enh32992	N/A	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	9624				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2928	hg19	N/A	N/A	N/A	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	8797				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2929	hg19	N/A	enh32993	N/A	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	7092				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2930	hg19	N/A	enh32993	fant5676	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	6802				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2931	hg19	N/A	enh32993	N/A	Enhatls94373	enhancer	63A	|		|	CACCGCGAGAGCATTCCCTCTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	689				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2932	hg19	N/A	enh32992	N/A	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	14307				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2933	hg19	N/A	enh32992	fant5675	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	14011				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2934	hg19	N/A	enh32992	N/A	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	9624				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2935	hg19	N/A	N/A	N/A	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	8797				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2936	hg19	N/A	enh32993	N/A	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	7092				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2937	hg19	N/A	enh32993	fant5676	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	6802				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-88142	chr2	1617170	1632273	1613398	1628501	2938	hg19	N/A	enh32993	N/A	Enhatls94373	enhancer	63B	|		|	CACCGTGGAGCCCCACTACCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PXDN	chr2	1631886	1744515	689				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	68
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2939	hg19	N/A	enh29657	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	93198				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2940	hg19	N/A	N/A	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	85930				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2941	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83563				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2942	hg19	N/A	enh116159	fant42125	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83216				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2943	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83114				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2944	hg19	N/A	enh116159	fant42126	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	82603				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2945	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	82151				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2946	hg19	N/A	enh116159	fant42127	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	81948				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2947	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64A	|		|	CACCGTTGGCCAAAACTCCGGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	80940				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2948	hg19	N/A	enh29657	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	93198				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2949	hg19	N/A	N/A	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	85930				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2950	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83563				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2951	hg19	N/A	enh116159	fant42125	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83216				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2952	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	83114				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2953	hg19	N/A	enh116159	fant42126	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	82603				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2954	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	82151				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2955	hg19	N/A	enh116159	fant42127	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	81948				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-39889	chr12	66113657	66136553	65719877	65742773	2956	hg19	N/A	enh116159	N/A	Enhatls43127	enhancer	64B	|		|	CACCGACCCCCGCGCACTTAACGCA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					HMGA2	chr12	65824459	65966291	80940				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5199
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2957	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	88547				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2958	hg19	N/A	enh22426	fant19262	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	87704				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2959	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	87173				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2960	hg19	N/A	enh22426	fant19263	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	86795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2961	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	76994				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2962	hg19	N/A	enh22426	fant19264	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	76655				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2963	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65A	|		|	CACCGTCACGCTCGGCGCTACGTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	69033				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2964	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	88547				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2965	hg19	N/A	enh22426	fant19262	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	87704				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2966	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	87173				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2967	hg19	N/A	enh22426	fant19263	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	86795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2968	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	76994				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2969	hg19	N/A	enh22426	fant19264	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	76655				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-133911	chr5	90567233	90592481	91271416	91296664	2970	hg19	N/A	enh22426	N/A	Enhatls143056	enhancer	65B	|		|	CACCGCAACACAGAACACTTAAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARRDC3	chr5	91368630	91383317	69033				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3702
enhrx-156734	chr8	11726060	11760068	11868551	11902559	2971	hg19	N/A	N/A	fant28715	N/A	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	2823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	525
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2972	hg19	N/A	enh10170	N/A	N/A	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	3164				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2973	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	3609				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2974	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	5228				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2975	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	5623				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2976	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	8294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2977	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	8715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2978	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	12354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2979	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	12464				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2980	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	16632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2981	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	16979				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2982	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	17769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2983	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18187				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2984	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18771				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2985	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18960				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2986	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	19259				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2987	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	19612				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2988	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	21662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2989	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	21851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2990	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	22125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2991	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	22377				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2992	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	27656				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2993	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	28220				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2994	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	28900				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2995	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67A	|		|	CACCGAAGGGTGAGCGCTATGCTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	29120				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156734	chr8	11726060	11760068	11868551	11902559	2996	hg19	N/A	N/A	fant28715	N/A	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	2823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	525
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2997	hg19	N/A	enh10170	N/A	N/A	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	3164				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2998	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	3609				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	2999	hg19	N/A	enh10170	fant28716	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	5228				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3000	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	5623				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3001	hg19	N/A	enh10170	fant28717	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	8294				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3002	hg19	N/A	enh10170	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	8715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3003	hg19	N/A	N/A	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	12354				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3004	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	12464				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3005	hg19	N/A	enh24751	fant28718	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	16632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3006	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	16979				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3007	hg19	N/A	enh24751	fant28719	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	17769				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3008	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18187				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3009	hg19	N/A	enh24751	fant28720	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18771				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3010	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	18960				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3011	hg19	N/A	enh24751	fant28721	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	19259				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3012	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	19612				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3013	hg19	N/A	enh24751	fant28722	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	21662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3014	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	21851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3015	hg19	N/A	enh24751	fant28723	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	22125				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3016	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	22377				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3017	hg19	N/A	enh24751	fant28724	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	27656				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3018	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	28220				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3019	hg19	N/A	enh24751	fant28725	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	28900				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-156735	chr8	11726060	11760068	11868551	11902559	3020	hg19	N/A	enh24751	N/A	Enhatls167443	enhancer	67B	|		|	CACCGATACGGGCATGTGATTCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CTSB	chr8	11842523	11869533	29120				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	526
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3021	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	76597				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3022	hg19	N/A	enh12071	fant2434	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	81558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3023	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	81970				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3024	hg19	N/A	enh12071	fant2435	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	85198				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3025	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	85406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3026	hg19	N/A	enh12071	fant2436	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	89619				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3027	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69A	|		|	CACCGAACATACATACCACGGTCTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ABCD3	chr1	94418388	94518663	70770				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3028	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	76597				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3029	hg19	N/A	enh12071	fant2434	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	81558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3030	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	81970				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3031	hg19	N/A	enh12071	fant2435	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	85198				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3032	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	85406				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3033	hg19	N/A	enh12071	fant2436	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGAP29	chr1	94168904	94237633	89619				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-8047	chr1	94782800	94800901	94317244	94335345	3034	hg19	N/A	enh12071	N/A	Enhatls8718	enhancer	69B	|		|	CACCGACTGGAGGGTCATTCGTGTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ABCD3	chr1	94418388	94518663	70770				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	8046
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3035	hg19	N/A	enh85085	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	5297				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3036	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3037	hg19	N/A	N/A	fant30048	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3038	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3039	hg19	N/A	N/A	fant30049	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3040	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3041	hg19	N/A	N/A	fant30050	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3042	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3043	hg19	N/A	enh25109	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3044	hg19	N/A	enh25109	fant30051	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3045	hg19	N/A	enh25109	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3046	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71A	|		|	CACCGCAAGCTCCAGCACCCGTGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3047	hg19	N/A	enh85085	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	5297				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3048	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3049	hg19	N/A	N/A	fant30048	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3050	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3051	hg19	N/A	N/A	fant30049	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3052	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3053	hg19	N/A	N/A	fant30050	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3054	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3055	hg19	N/A	enh25109	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3056	hg19	N/A	enh25109	fant30051	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3057	hg19	N/A	enh25109	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	86991697	87022615	85979468	86010386	3058	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	71B	|		|	CACCGAACCCAGATGAATCCGAAGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3059	hg19	N/A	enh16425	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3060	hg19	N/A	enh16425	fant49388	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3061	hg19	N/A	enh16425	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3062	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3063	hg19	N/A	N/A	fant49389	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	1837				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3064	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	1971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3065	hg19	N/A	N/A	fant49390	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	3784				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3066	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	4078				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3067	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	5578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3068	hg19	N/A	enh3814	fant49391	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	10391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3069	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	11127				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3070	hg19	N/A	enh3814	fant49392	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	12774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3071	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	13166				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3072	hg19	N/A	enh3814	fant49393	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	21753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3073	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	22571				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3074	hg19	N/A	enh3814	fant49394	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	23333				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3075	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72A	|		|	CACCGCCCTTAAAGGGCCGCGTTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	23501				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3076	hg19	N/A	enh16425	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3077	hg19	N/A	enh16425	fant49388	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3078	hg19	N/A	enh16425	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3079	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3080	hg19	N/A	N/A	fant49389	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	1837				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3081	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	1971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3082	hg19	N/A	N/A	fant49390	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	3784				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3083	hg19	N/A	N/A	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	4078				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3084	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	5578				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3085	hg19	N/A	enh3814	fant49391	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	10391				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3086	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	11127				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3087	hg19	N/A	enh3814	fant49392	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	12774				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3088	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	13166				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3089	hg19	N/A	enh3814	fant49393	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	21753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3090	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	22571				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3091	hg19	N/A	enh3814	fant49394	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	23333				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-59310	chr15	93344779	93383966	92801549	92840736	3092	hg19	N/A	enh3814	N/A	Enhatls63861	enhancer	72B	|		|	CACCGAGGCCGCTGAATTAACCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM174B	chr15	92617447	92809798	23501				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	6012
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3093	hg19	N/A	enh7907	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	101558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3094	hg19	N/A	N/A	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	99428				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3095	hg19	N/A	enh7908	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	94977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3096	hg19	N/A	enh7908	fant15424	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	94715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3097	hg19	N/A	enh7908	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	92658				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3098	hg19	N/A	N/A	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	89308				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3099	hg19	N/A	enh21409	N/A	Enhatls132573	enhancer	73A	|		|	CACCGTGGTCTGGATCTATAAGGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	82798				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3100	hg19	N/A	enh7907	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	101558				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3101	hg19	N/A	N/A	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	99428				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3102	hg19	N/A	enh7908	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	94977				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3103	hg19	N/A	enh7908	fant15424	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	94715				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3104	hg19	N/A	enh7908	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	92658				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3105	hg19	N/A	N/A	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	89308				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-123884	chr4	25537562	25566060	25535940	25564438	3106	hg19	N/A	enh21409	N/A	Enhatls132573	enhancer	73B	|		|	CACCGATGGTATTAATTGGTAACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SLC34A2	chr4	25648010	25678748	82798				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1428
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3107	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	3030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3108	hg19	N/A	enh25548	fant32213	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12322				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3109	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3110	hg19	N/A	enh25548	fant32214	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12675				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3111	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	13025				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3112	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	15138				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3113	hg19	N/A	N/A	fant32215	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	17650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3114	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	17875				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3115	hg19	N/A	enh106966	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	19163				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3116	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21964				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3117	hg19	N/A	enh25549	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21727				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3118	hg19	N/A	enh25549	fant32216	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21559				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3119	hg19	N/A	enh25549	N/A	Enhatls175502	enhancer	75A	|		|	CACCGTAGGTACCAATACATAGGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	2310				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3120	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	3030				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3121	hg19	N/A	enh25548	fant32213	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12322				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3122	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12524				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3123	hg19	N/A	enh25548	fant32214	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	12675				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3124	hg19	N/A	enh25548	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	13025				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3125	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	15138				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3126	hg19	N/A	N/A	fant32215	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	17650				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3127	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	17875				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3128	hg19	N/A	enh106966	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SPAAR	chr9	35909489	35911686	19163				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3129	hg19	N/A	N/A	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21964				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3130	hg19	N/A	enh25549	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21727				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3131	hg19	N/A	enh25549	fant32216	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	21559				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-164374	chr9	35923732	35949509	35923735	35949512	3132	hg19	N/A	enh25549	N/A	Enhatls175502	enhancer	75B	|		|	CACCGTTTGGGCTGGACGGTTTGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					OR2S2	chr9	35957107	35958154	2310				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1641
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3133	hg19	N/A	enh990	N/A	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	16618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3134	hg19	N/A	enh990	fant5265	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	25067				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3135	hg19	N/A	enh990	N/A	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	25339				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3136	hg19	N/A	N/A	N/A	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	32971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3137	hg19	N/A	N/A	fant5266	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	33487				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3138	hg19	N/A	N/A	N/A	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	33763				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3139	hg19	N/A	enh991	N/A	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	34265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3140	hg19	N/A	enh991	fant5267	Enhatls18276	enhancer	77A	|		|	CACCGCAGAACTTTATCGCCCGCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	43393				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3141	hg19	N/A	enh990	N/A	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	16618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3142	hg19	N/A	enh990	fant5265	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	25067				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3143	hg19	N/A	enh990	N/A	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	25339				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3144	hg19	N/A	N/A	N/A	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	32971				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3145	hg19	N/A	N/A	fant5266	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	33487				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3146	hg19	N/A	N/A	N/A	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	33763				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3147	hg19	N/A	enh991	N/A	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	34265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-16675	chr1	234631993	234658439	234496247	234522693	3148	hg19	N/A	enh991	fant5267	Enhatls18276	enhancer	77B	|		|	CACCGATAACCCGGGTCTGCCCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TARBP1	chr1	234391312	234479179	43393				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	16674
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3149	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	10				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3150	hg19	N/A	enh38865	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	6585				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3151	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	12795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3152	hg19	N/A	enh38866	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	17745				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3153	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	30375				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3154	hg19	N/A	enh23091	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	30825				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3155	hg19	N/A	enh23091	fant21889	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	34672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3156	hg19	N/A	enh23091	N/A	Enhatls148781	enhancer	78A	|		|	CACCGAACCTGTCAACACGGGAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	35116				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3157	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	10				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3158	hg19	N/A	enh38865	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	6585				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3159	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	12795				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3160	hg19	N/A	enh38866	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	17745				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3161	hg19	N/A	N/A	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	30375				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3162	hg19	N/A	enh23091	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	30825				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3163	hg19	N/A	enh23091	fant21889	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	34672				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-139170	chr6	18471535	18504457	18471304	18504226	3164	hg19	N/A	enh23091	N/A	Enhatls148781	enhancer	78B	|		|	CACCGTGGCCATGGGAACGTATGTT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF144B	chr6	18387349	18468870	35116				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	758
enhrx-117522	chr3	112360857	112371215	112642010	112652368	3165	hg19	N/A	enh97333	N/A	N/A	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5651
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3166	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	4844				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3167	hg19	N/A	N/A	fant12985	Enhatls125777	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	5949				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3168	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	6120				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3169	hg19	N/A	N/A	fant12986	Enhatls125777	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	10234				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3170	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79A	|		|	CACCGTTATGGCCATTACGGCACT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	10566				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117522	chr3	112360857	112371215	112642010	112652368	3171	hg19	N/A	enh97333	N/A	N/A	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5651
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3172	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	4844				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3173	hg19	N/A	N/A	fant12985	Enhatls125777	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	5949				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3174	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	6120				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3175	hg19	N/A	N/A	fant12986	Enhatls125777	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	10234				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112360857	112371215	112642010	112652368	3176	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	79B	|		|	CACCGTTACCGTGCTTCTAGCACGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	10566				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3177	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	123430				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3178	hg19	N/A	enh22965	fant21365	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	127265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3179	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	127318				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3180	hg19	N/A	enh22965	fant21366	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	148653				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3181	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	148990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3182	hg19	N/A	enh22965	fant21367	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	151900				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3183	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	152185				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3184	hg19	N/A	enh22965	fant21368	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	156239				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3185	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	157013				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3186	hg19	N/A	enh22965	fant21369	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	170200				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3187	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	170427				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3188	hg19	N/A	enh22965	fant21370	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	171068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3189	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	171375				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3190	hg19	N/A	N/A	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	173924				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3191	hg19	N/A	enh22966	N/A	Enhatls148271	enhancer	80A	|		|	CACCGTACCCCTGGGACACGTCACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	177359				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3192	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	123430				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3193	hg19	N/A	enh22965	fant21365	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	127265				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3194	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	127318				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3195	hg19	N/A	enh22965	fant21366	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	148653				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3196	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	148990				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3197	hg19	N/A	enh22965	fant21367	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	151900				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3198	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	152185				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3199	hg19	N/A	enh22965	fant21368	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	156239				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3200	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	157013				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3201	hg19	N/A	enh22965	fant21369	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	170200				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3202	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	170427				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3203	hg19	N/A	enh22965	fant21370	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	171068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3204	hg19	N/A	enh22965	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	171375				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3205	hg19	N/A	N/A	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	173924				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-138688	chr6	6781579	6834492	6781346	6834259	3206	hg19	N/A	enh22966	N/A	Enhatls148271	enhancer	80B	|		|	CACCGTGAATGGCCCGCACATCAAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					LY86	chr6	6588107	6654983	177359				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	276
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3207	hg19	N/A	enh24018	N/A	Enhatls158484	enhancer	81A	|		|	CACCGGATGGCAAGCCTTAACACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	20530				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3208	hg19	N/A	N/A	N/A	Enhatls158484	enhancer	81A	|		|	CACCGGATGGCAAGCCTTAACACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	26452				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3209	hg19	N/A	enh39961	N/A	Enhatls158484	enhancer	81A	|		|	CACCGGATGGCAAGCCTTAACACA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	30579				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3210	hg19	N/A	enh24018	N/A	Enhatls158484	enhancer	81B	|		|	CACCGATGTGGAATGGATACGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	20530				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3211	hg19	N/A	N/A	N/A	Enhatls158484	enhancer	81B	|		|	CACCGATGTGGAATGGATACGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	26452				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-148297	chr7	20282480	20290541	20242857	20250918	3212	hg19	N/A	enh39961	N/A	Enhatls158484	enhancer	81B	|		|	CACCGATGTGGAATGGATACGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MACC1	chr7	20134654	20217404	30579				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1109
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3213	hg19	N/A	enh25110	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3214	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3215	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3216	hg19	N/A	enh106829	fant30052	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3217	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3218	hg19	N/A	enh106829	fant30053	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3219	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3220	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3221	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82A	|		|	CACCGTAGCCTTACTTGACTCGCCT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PSKH2	chr8	86047108	86069668	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3222	hg19	N/A	enh25110	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3223	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3224	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3225	hg19	N/A	enh106829	fant30052	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3226	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3227	hg19	N/A	enh106829	fant30053	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3228	hg19	N/A	enh106829	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3229	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ATP6V0D2	chr8	85987322	86154225	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-159951	chr8	87037748	87049864	86025519	86037635	3230	hg19	N/A	N/A	N/A	Enhatls170859	enhancer	82B	|		|	CACCGTTGGCAACCCATGGCACCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PSKH2	chr8	86047108	86069668	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3742
enhrx-37544	chr12	43343145	43360860	42949342	42967057	3231	hg19	N/A	N/A	N/A	Enhatls40659	enhancer	83A	|		|	CACCGAGAAGGAAGCAGGTACCCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	357881				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43343145	43360860	42949342	42967057	3232	hg19	N/A	enh2289	N/A	Enhatls40659	enhancer	83A	|		|	CACCGAGAAGGAAGCAGGTACCCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	364928				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43343145	43360860	42949342	42967057	3233	hg19	N/A	N/A	N/A	Enhatls40659	enhancer	83B	|		|	CACCGGAACAAAGATCGTGCCTAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	357881				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43343145	43360860	42949342	42967057	3234	hg19	N/A	enh2289	N/A	Enhatls40659	enhancer	83B	|		|	CACCGGAACAAAGATCGTGCCTAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	364928				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3235	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	2				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3236	hg19	N/A	enh24945	fant29380	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	3729				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3237	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	4081				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3238	hg19	N/A	enh24945	fant29381	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	9842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3239	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	10235				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3240	hg19	N/A	N/A	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	11927				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3241	hg19	N/A	enh24946	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	13377				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3242	hg19	N/A	enh24946	fant29382	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	19274				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3243	hg19	N/A	enh24946	N/A	Enhatls169206	enhancer	84A	|		|	CACCGAGCTCGATGTGCATACAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	19709				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3244	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	2				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3245	hg19	N/A	enh24945	fant29380	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	3729				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3246	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	4081				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3247	hg19	N/A	enh24945	fant29381	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	9842				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3248	hg19	N/A	enh24945	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	10235				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3249	hg19	N/A	N/A	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	11927				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3250	hg19	N/A	enh24946	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	13377				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3251	hg19	N/A	enh24946	fant29382	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	19274				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-158373	chr8	40014562	40040332	40157043	40182813	3252	hg19	N/A	enh24946	N/A	Enhatls169206	enhancer	84B	|		|	CACCGTAGGCTATTCACGGAAGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TCIM	chr8	40153481	40155310	19709				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2164
enhrx-163424	chr9	16030467	16041809	16030469	16041811	3253	hg19	N/A	enh41744	N/A	Enhatls174505	enhancer	85A	|		|	CACCGCTAGGAATGCATCCGTGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC171	chr9	15553042	15974037	50431				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	691
enhrx-163424	chr9	16030467	16041809	16030469	16041811	3254	hg19	N/A	enh41744	N/A	Enhatls174505	enhancer	85B	|		|	CACCGATGGCCCCCCTTGAGCTACG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC171	chr9	15553042	15974037	50431				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	691
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3255	hg19	N/A	enh8885	N/A	Enhatls147147	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	118036				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3256	hg19	N/A	enh8885	fant20910	Enhatls147147	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	126340				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3257	hg19	N/A	enh8885	N/A	Enhatls147147	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	126675				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3258	hg19	N/A	enh8885	N/A	N/A	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	129365				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3259	hg19	N/A	enh8886	N/A	N/A	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	134438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3260	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	134555				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3261	hg19	N/A	enh8886	fant20911	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	134720				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3262	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	125431				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3263	hg19	N/A	enh8886	fant20912	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	125186				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3264	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	123785				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3265	hg19	N/A	enh8886	fant20913	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	123598				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3266	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	121975				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3267	hg19	N/A	enh8886	fant20914	Enhatls147148	enhancer	86A	|		|	CACCGATTTGTGCTGCGTCAACTGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	121323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3268	hg19	N/A	enh8885	N/A	Enhatls147147	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	118036				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3269	hg19	N/A	enh8885	fant20910	Enhatls147147	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	126340				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3270	hg19	N/A	enh8885	N/A	Enhatls147147	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	126675				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137676	chr5	173162366	173193843	173735363	173766840	3271	hg19	N/A	enh8885	N/A	N/A	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	129365				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7467
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3272	hg19	N/A	enh8886	N/A	N/A	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	134438				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3273	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					BOD1	chr5	173607144	173616653	134555				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3274	hg19	N/A	enh8886	fant20911	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	134720				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3275	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	125431				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3276	hg19	N/A	enh8886	fant20912	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	125186				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3277	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	123785				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3278	hg19	N/A	enh8886	fant20913	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	123598				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3279	hg19	N/A	enh8886	N/A	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	121975				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-137677	chr5	173162366	173193843	173735363	173766840	3280	hg19	N/A	enh8886	fant20914	Enhatls147148	enhancer	86B	|		|	CACCGAGATGTCTCCGTGCTTAGCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CPEB4	chr5	173888348	173961980	121323				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7468
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3281	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	10824				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3282	hg19	N/A	enh90365	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	13537				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3283	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	17931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3284	hg19	N/A	enh55670	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	27054				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3285	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	31204				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3286	hg19	N/A	enh38863	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	40534				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3287	hg19	N/A	enh38863	fant21866	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	43722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3288	hg19	N/A	enh38863	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	44167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3289	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87A	|		|	CACCGAGGGGTCCGAGACGCGCCAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	46148				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3290	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	10824				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3291	hg19	N/A	enh90365	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	13537				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3292	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	17931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3293	hg19	N/A	enh55670	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	27054				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3294	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	31204				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3295	hg19	N/A	enh38863	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	40534				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3296	hg19	N/A	enh38863	fant21866	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	43722				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3297	hg19	N/A	enh38863	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	44167				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-139162	chr6	18277001	18313890	18276770	18313659	3298	hg19	N/A	N/A	N/A	Enhatls148773	enhancer	87B	|		|	CACCGACTGTACCTAGCGCACCCTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					DEK	chr6	18223859	18264541	46148				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	750
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3299	hg19	N/A	enh36707	N/A	Enhatls134506	enhancer	88A	|		|	CACCGCTAGAGTCACGGACTCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	43292				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3300	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	88A	|		|	CACCGCTAGAGTCACGGACTCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	44457				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3301	hg19	N/A	enh59348	N/A	Enhatls134506	enhancer	88A	|		|	CACCGCTAGAGTCACGGACTCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	46358				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3302	hg19	N/A	enh59348	fant15973	Enhatls134506	enhancer	88A	|		|	CACCGCTAGAGTCACGGACTCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	48165				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3303	hg19	N/A	enh59348	N/A	Enhatls134506	enhancer	88A	|		|	CACCGCTAGAGTCACGGACTCCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	48312				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3304	hg19	N/A	enh36707	N/A	Enhatls134506	enhancer	88B	|		|	CACCGAAATTTGATTAGGCACCCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	43292				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3305	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	88B	|		|	CACCGAAATTTGATTAGGCACCCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	44457				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3306	hg19	N/A	enh59348	N/A	Enhatls134506	enhancer	88B	|		|	CACCGAAATTTGATTAGGCACCCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	46358				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3307	hg19	N/A	enh59348	fant15973	Enhatls134506	enhancer	88B	|		|	CACCGAAATTTGATTAGGCACCCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	48165				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74529930	74544535	73664213	73678818	3308	hg19	N/A	enh59348	N/A	Enhatls134506	enhancer	88B	|		|	CACCGAAATTTGATTAGGCACCCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RASSF6	chr4	73571549	73620631	48312				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3309	hg19	N/A	enh29534	N/A	Enhatls40659	enhancer	89A	|		|	CACCGTGGAGTCTAGGTGCCGCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	143677				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3310	hg19	N/A	N/A	N/A	Enhatls40659	enhancer	89A	|		|	CACCGTGGAGTCTAGGTGCCGCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	156719				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3311	hg19	N/A	enh29535	N/A	Enhatls40659	enhancer	89A	|		|	CACCGTGGAGTCTAGGTGCCGCAAC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	164662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3312	hg19	N/A	enh29534	N/A	Enhatls40659	enhancer	89B	|		|	CACCGCTAGCTTCCATAAGTGACGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	143677				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3313	hg19	N/A	N/A	N/A	Enhatls40659	enhancer	89B	|		|	CACCGCTAGCTTCCATAAGTGACGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	156719				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37544	chr12	43137260	43154889	42743458	42761087	3314	hg19	N/A	enh29535	N/A	Enhatls40659	enhancer	89B	|		|	CACCGCTAGCTTCCATAAGTGACGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRICKLE1	chr12	42456756	42590355	164662				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2854
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3315	hg19	N/A	N/A	N/A	Enhatls40611	enhancer	90A	|		|	CACCGAGTGCACAGCGGTTAGATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	71302				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3316	hg19	N/A	enh2277	N/A	Enhatls40611	enhancer	90A	|		|	CACCGAGTGCACAGCGGTTAGATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	60237				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3317	hg19	N/A	enh2277	fant41484	Enhatls40611	enhancer	90A	|		|	CACCGAGTGCACAGCGGTTAGATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	60052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3318	hg19	N/A	enh2277	N/A	Enhatls40611	enhancer	90A	|		|	CACCGAGTGCACAGCGGTTAGATC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	52212				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3319	hg19	N/A	N/A	N/A	Enhatls40611	enhancer	90B	|		|	CACCGTATAAAATGGTGGACGCTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	71302				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3320	hg19	N/A	enh2277	N/A	Enhatls40611	enhancer	90B	|		|	CACCGTATAAAATGGTGGACGCTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	60237				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3321	hg19	N/A	enh2277	fant41484	Enhatls40611	enhancer	90B	|		|	CACCGTATAAAATGGTGGACGCTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	60052				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-37495	chr12	42399782	42421649	42005980	42027847	3322	hg19	N/A	enh2277	N/A	Enhatls40611	enhancer	90B	|		|	CACCGTATAAAATGGTGGACGCTGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GXYLT1	chr12	42081844	42144874	52212				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2805
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3323	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	26688				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3324	hg19	N/A	enh56896	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	31378				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3325	hg19	N/A	enh56896	fant31723	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	34347				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3326	hg19	N/A	enh56896	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	34773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3327	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	36708				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3328	hg19	N/A	enh85323	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	36961				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3329	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91A	|		|	CACCGTTGAACCTGGAGACCGTTGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	42408				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3330	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	26688				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3331	hg19	N/A	enh56896	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	31378				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3332	hg19	N/A	enh56896	fant31723	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	34347				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3333	hg19	N/A	enh56896	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	34773				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3334	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	36708				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3335	hg19	N/A	enh85323	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	36961				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-162940	chr9	4327651	4365328	4327651	4365328	3336	hg19	N/A	N/A	N/A	Enhatls174015	enhancer	91B	|		|	CACCGGCCCCCAGAAAAACGACGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					GLIS3	chr9	3824126	4300068	42408				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	207
enhrx-56405	chr15	58673068	58687089	58380869	58394890	3337	hg19	N/A	N/A	N/A	Enhatls60686	enhancer	92A	|		|	CACCGATGCCTCTTTCTTCGAACAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ALDH1A2	chr15	57953423	58473913	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3107
enhrx-56405	chr15	58673068	58687089	58380869	58394890	3338	hg19	N/A	enh16174	N/A	Enhatls60686	enhancer	92A	|		|	CACCGATGCCTCTTTCTTCGAACAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ALDH1A2	chr15	57953423	58473913	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3107
enhrx-56405	chr15	58673068	58687089	58380869	58394890	3339	hg19	N/A	N/A	N/A	Enhatls60686	enhancer	92B	|		|	CACCGAAGGAAGGCCCCTATCATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ALDH1A2	chr15	57953423	58473913	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3107
enhrx-56405	chr15	58673068	58687089	58380869	58394890	3340	hg19	N/A	enh16174	N/A	Enhatls60686	enhancer	92B	|		|	CACCGAAGGAAGGCCCCTATCATG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ALDH1A2	chr15	57953423	58473913	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3107
enhrx-121861	chr3	189654709	189668263	189936920	189950474	3341	hg19	N/A	enh21214	N/A	Enhatls130414	enhancer	94A	|		|	CACCGGCCCTCAGGTCTACTTAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P3H2	chr3	189956727	190122437	818				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9990
enhrx-121861	chr3	189654709	189668263	189936920	189950474	3342	hg19	N/A	enh21214	N/A	Enhatls130414	enhancer	94B	|		|	CACCGCACCAGGAAACTCCGACCGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					P3H2	chr3	189956727	190122437	818				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9990
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3343	hg19	N/A	enh37681	N/A	Enhatls140101	enhancer	95A	|		|	CACCGATGCGCTACTACCGACAGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	82958				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3344	hg19	N/A	N/A	N/A	Enhatls140101	enhancer	95A	|		|	CACCGATGCGCTACTACCGACAGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	82468				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3345	hg19	N/A	enh37682	N/A	Enhatls140101	enhancer	95A	|		|	CACCGATGCGCTACTACCGACAGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	78318				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3346	hg19	N/A	N/A	N/A	Enhatls140101	enhancer	95A	|		|	CACCGATGCGCTACTACCGACAGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	71948				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3347	hg19	N/A	enh37681	N/A	Enhatls140101	enhancer	95B	|		|	CACCGTGTAGCGTGTGAAATTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	82958				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3348	hg19	N/A	N/A	N/A	Enhatls140101	enhancer	95B	|		|	CACCGTGTAGCGTGTGAAATTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	82468				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3349	hg19	N/A	enh37682	N/A	Enhatls140101	enhancer	95B	|		|	CACCGTGTAGCGTGTGAAATTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	78318				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-131077	chr5	31105322	31119407	31105215	31119300	3350	hg19	N/A	N/A	N/A	Enhatls140101	enhancer	95B	|		|	CACCGTGTAGCGTGTGAAATTGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CDH6	chr5	31193685	31329146	71948				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	868
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3351	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	27379				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3352	hg19	N/A	enh7449	fant12988	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	30692				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3353	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	30989				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3354	hg19	N/A	enh7449	fant12989	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	35632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3355	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	35851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3356	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	37931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3357	hg19	N/A	enh35770	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	38499				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3358	hg19	N/A	enh35770	fant12990	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	44222				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3359	hg19	N/A	enh35770	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	44435				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3360	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	50989				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3361	hg19	N/A	enh82701	N/A	Enhatls125777	enhancer	96A	|		|	CACCGACTGGCACAGTTCCGAAAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	56079				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3362	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	27379				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3363	hg19	N/A	enh7449	fant12988	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	30692				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3364	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	30989				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3365	hg19	N/A	enh7449	fant12989	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	35632				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3366	hg19	N/A	enh7449	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	35851				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3367	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	37931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3368	hg19	N/A	enh35770	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	38499				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3369	hg19	N/A	enh35770	fant12990	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	44222				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3370	hg19	N/A	enh35770	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	44435				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3371	hg19	N/A	N/A	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	50989				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-117523	chr3	112388012	112417892	112669165	112699045	3372	hg19	N/A	enh82701	N/A	Enhatls125777	enhancer	96B	|		|	CACCGATTAACATCTAGTCGCAAGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CCDC80	chr3	112596796	112641300	56079				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5652
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3373	hg19	N/A	enh83146	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	40083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3374	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	39569				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3375	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	36564				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3376	hg19	N/A	enh36708	fant15977	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	35338				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3377	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	35288				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3378	hg19	N/A	enh36708	fant15978	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	34912				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3379	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	33272				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3380	hg19	N/A	enh36708	fant15979	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	32889				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3381	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	31058				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3382	hg19	N/A	enh36708	fant15980	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	30808				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3383	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	30083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3384	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	28753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3385	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	24493				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3386	hg19	N/A	enh36709	fant15981	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	24321				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3387	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	23018				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3388	hg19	N/A	enh36709	fant15982	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	22823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3389	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	21889				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3390	hg19	N/A	enh36709	fant15983	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	21610				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3391	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	18519				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3392	hg19	N/A	enh36709	fant15984	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	18241				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3393	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	17521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3394	hg19	N/A	enh36709	fant15985	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	17152				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3395	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	16581				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3396	hg19	N/A	enh36709	fant15986	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	16387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3397	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	14618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3398	hg19	N/A	enh36709	fant15987	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	14113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3399	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	12897				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3400	hg19	N/A	enh36709	fant15988	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	12460				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3401	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	10147				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3402	hg19	N/A	enh36709	fant15989	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	9888				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3403	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	8613				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3404	hg19	N/A	enh36709	fant15990	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	8164				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3405	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7983				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3406	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7434				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3407	hg19	N/A	N/A	fant15991	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7091				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3408	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6184				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3409	hg19	N/A	N/A	fant15992	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6122				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3410	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3411	hg19	N/A	N/A	fant15993	Enhatls134506	enhancer	98A	|		|	CACCGGACCCTGTATTGTATGCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	5529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3412	hg19	N/A	enh83146	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	40083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3413	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	39569				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3414	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	36564				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3415	hg19	N/A	enh36708	fant15977	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	35338				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3416	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	35288				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3417	hg19	N/A	enh36708	fant15978	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	34912				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3418	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	33272				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3419	hg19	N/A	enh36708	fant15979	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	32889				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3420	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	31058				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3421	hg19	N/A	enh36708	fant15980	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	30808				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3422	hg19	N/A	enh36708	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	30083				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3423	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	28753				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3424	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	24493				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3425	hg19	N/A	enh36709	fant15981	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	24321				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3426	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	23018				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3427	hg19	N/A	enh36709	fant15982	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	22823				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3428	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	21889				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3429	hg19	N/A	enh36709	fant15983	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	21610				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3430	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	18519				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3431	hg19	N/A	enh36709	fant15984	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	18241				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3432	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	17521				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3433	hg19	N/A	enh36709	fant15985	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	17152				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3434	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	16581				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3435	hg19	N/A	enh36709	fant15986	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	16387				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3436	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	14618				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3437	hg19	N/A	enh36709	fant15987	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	14113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3438	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	12897				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3439	hg19	N/A	enh36709	fant15988	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	12460				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3440	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	10147				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3441	hg19	N/A	enh36709	fant15989	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	9888				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3442	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	8613				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3443	hg19	N/A	enh36709	fant15990	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	8164				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3444	hg19	N/A	enh36709	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7983				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3445	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7434				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3446	hg19	N/A	N/A	fant15991	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	7091				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3447	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6184				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3448	hg19	N/A	N/A	fant15992	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6122				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3449	hg19	N/A	N/A	N/A	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	6113				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-125728	chr4	74563322	74600190	73697605	73734473	3450	hg19	N/A	N/A	fant15993	Enhatls134506	enhancer	98B	|		|	CACCGTGAGGTATTTAGCGGGTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL8	chr4	73740540	73743716	5529				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3272
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3451	hg19	N/A	enh37843	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	314674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3452	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	312179				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3453	hg19	N/A	N/A	fant18611	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	311879				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3454	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	311564				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3455	hg19	N/A	enh97673	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	307414				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3456	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	306584				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3457	hg19	N/A	enh45854	N/A	Enhatls141392	enhancer	99A	|		|	CACCGTCTAGAAAGATCGTGTCTTG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	301974				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3458	hg19	N/A	enh37843	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	314674				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3459	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	312179				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3460	hg19	N/A	N/A	fant18611	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	311879				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3461	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	311564				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3462	hg19	N/A	enh97673	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	307414				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3463	hg19	N/A	N/A	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	306584				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-132298	chr5	57428098	57446753	58132271	58150926	3464	hg19	N/A	enh45854	N/A	Enhatls141392	enhancer	99B	|		|	CACCGCACACACAGCTTGGTCGATT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PLK2	chr5	58453981	58460139	301974				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2089
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3465	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	124917				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3466	hg19	N/A	enh41802	fant32011	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	124479				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3467	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	121054				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3468	hg19	N/A	enh41802	fant32012	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	120707				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3469	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	117950				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3470	hg19	N/A	enh41802	fant32013	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	117638				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3471	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100A	|		|	CACCGAGATGAAATAACCCGTGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	113862				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3472	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	124917				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3473	hg19	N/A	enh41802	fant32011	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	124479				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3474	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	121054				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3475	hg19	N/A	enh41802	fant32012	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	120707				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3476	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	117950				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3477	hg19	N/A	enh41802	fant32013	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	117638				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-163656	chr9	21676981	21688433	21676982	21688434	3478	hg19	N/A	enh41802	N/A	Enhatls174749	enhancer	100B	|		|	CACCGACTGCTCCTCAAACAGCGAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MTAP	chr9	21802635	21937651	113862				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	923
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3479	hg19	N/A	enh22350	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	293888				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3480	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	303902				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3481	hg19	N/A	enh22351	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	306248				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3482	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	312242				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3483	hg19	N/A	enh22352	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	313068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3484	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	321678				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3485	hg19	N/A	enh110210	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	322208				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3486	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	326358				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3487	hg19	N/A	enh37977	N/A	Enhatls142204	enhancer	101A	|		|	CACCGTAAGCAGCCTGTCTGTCGAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	328145				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3488	hg19	N/A	enh22350	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	293888				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3489	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	303902				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3490	hg19	N/A	enh22351	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	306248				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3491	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	312242				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3492	hg19	N/A	enh22352	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	313068				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3493	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	321678				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3494	hg19	N/A	enh110210	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	322208				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3495	hg19	N/A	N/A	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	326358				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-133087	chr5	73536666	73567725	74240841	74271900	3496	hg19	N/A	enh37977	N/A	Enhatls142204	enhancer	101B	|		|	CACCGGTGAATATTGCGAATGCCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ARHGEF28	chr5	73626157	73941993	328145				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	2878
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3497	hg19	N/A	enh14394	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	84359				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3498	hg19	N/A	enh14394	fant40460	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	84034				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3499	hg19	N/A	enh14394	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	80548				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3500	hg19	N/A	N/A	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	79958				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3501	hg19	N/A	enh14395	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	70188				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3502	hg19	N/A	N/A	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	66978				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3503	hg19	N/A	enh74941	N/A	Enhatls37383	enhancer	102A	|		|	CACCGCTTTCTTCCTTCTGCGACGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	62828				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3504	hg19	N/A	enh14394	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	84359				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3505	hg19	N/A	enh14394	fant40460	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	84034				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3506	hg19	N/A	enh14394	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	80548				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3507	hg19	N/A	N/A	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	79958				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3508	hg19	N/A	enh14395	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	70188				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3509	hg19	N/A	N/A	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	66978				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-34454	chr11	129593849	129620764	129723954	129750869	3510	hg19	N/A	enh74941	N/A	Enhatls37383	enhancer	102B	|		|	CACCGAGTGCATGCTCGTGTGTCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					TMEM45B	chr11	129815847	129860003	62828				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	9123
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3511	hg19	N/A	enh72411	N/A	Enhatls153700	enhancer	104A	|		|	CACCGATTCAAGGCTACACGATGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	164790				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3512	hg19	N/A	N/A	N/A	Enhatls153700	enhancer	104A	|		|	CACCGATTCAAGGCTACACGATGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	172073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3513	hg19	N/A	enh39277	N/A	Enhatls153700	enhancer	104A	|		|	CACCGATTCAAGGCTACACGATGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	175780				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3514	hg19	N/A	N/A	N/A	Enhatls153700	enhancer	104A	|		|	CACCGATTCAAGGCTACACGATGTC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SIM1	chr6	100385008	100464921	184728				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3515	hg19	N/A	enh72411	N/A	Enhatls153700	enhancer	104B	|		|	CACCGGAGACGCGTATCAGCATCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	164790				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3516	hg19	N/A	N/A	N/A	Enhatls153700	enhancer	104B	|		|	CACCGGAGACGCGTATCAGCATCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	172073				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3517	hg19	N/A	enh39277	N/A	Enhatls153700	enhancer	104B	|		|	CACCGGAGACGCGTATCAGCATCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MCHR2	chr6	99918518	99994247	175780				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-143822	chr6	100608923	100630940	100161047	100183064	3518	hg19	N/A	N/A	N/A	Enhatls153700	enhancer	104B	|		|	CACCGGAGACGCGTATCAGCATCC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					SIM1	chr6	100385008	100464921	184728				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	5410
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3519	hg19	N/A	N/A	N/A	Enhatls83079	enhancer	105A	|		|	CACCGTTTCATTTGCTCACGCAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	5082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3520	hg19	N/A	enh4753	N/A	Enhatls83079	enhancer	105A	|		|	CACCGTTTCATTTGCTCACGCAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	23280				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3521	hg19	N/A	N/A	N/A	Enhatls83079	enhancer	105A	|		|	CACCGTTTCATTTGCTCACGCAAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	34090				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3522	hg19	N/A	N/A	N/A	Enhatls83079	enhancer	105B	|		|	CACCGTGGGAGCATGTCCAATTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	5082				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3523	hg19	N/A	enh4753	N/A	Enhatls83079	enhancer	105B	|		|	CACCGTGGGAGCATGTCCAATTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	23280				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-77423	chr18	30369486	30394532	32789523	32814569	3524	hg19	N/A	N/A	N/A	Enhatls83079	enhancer	105B	|		|	CACCGTGGGAGCATGTCCAATTAGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					KLHL14	chr18	32672672	32773023	34090				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	1441
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3525	hg19	N/A	enh36714	N/A	Enhatls134522	enhancer	106A	|		|	CACCGGGGACAGACTGATAGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	42381				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3526	hg19	N/A	enh36714	fant16003	Enhatls134522	enhancer	106A	|		|	CACCGGGGACAGACTGATAGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	45880				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3527	hg19	N/A	enh36714	N/A	Enhatls134522	enhancer	106A	|		|	CACCGGGGACAGACTGATAGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	46197				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3528	hg19	N/A	N/A	N/A	Enhatls134522	enhancer	106A	|		|	CACCGGGGACAGACTGATAGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	48931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3529	hg19	N/A	enh83150	N/A	Enhatls134522	enhancer	106A	|		|	CACCGGGGACAGACTGATAGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	49561				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3530	hg19	N/A	enh36714	N/A	Enhatls134522	enhancer	106B	|		|	CACCGCCAATGTTCACGATATGCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	42381				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3531	hg19	N/A	enh36714	fant16003	Enhatls134522	enhancer	106B	|		|	CACCGCCAATGTTCACGATATGCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	45880				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3532	hg19	N/A	enh36714	N/A	Enhatls134522	enhancer	106B	|		|	CACCGCCAATGTTCACGATATGCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	46197				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3533	hg19	N/A	N/A	N/A	Enhatls134522	enhancer	106B	|		|	CACCGCCAATGTTCACGATATGCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	48931				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-125744	chr4	74781391	74788553	73915674	73922836	3534	hg19	N/A	enh83150	N/A	Enhatls134522	enhancer	106B	|		|	CACCGCCAATGTTCACGATATGCAT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					CXCL1	chr4	73869392	73871308	49561				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	3288
enhrx-167446	chr9	116501451	116501470	113739171	113739190	3535	hg19	N/A	enh42206	N/A	Enhatls179208	enhancer	DORM1	|		|	CACCGGCAGTACTGGTCGAGACTA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					ZNF618	chr9	113876281	114056593	132246				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	4713
enhrx-lit16	chr3	138666023	138666042	138947181	138947200	3536	hg19					enhancer	FOXL2NB-g1	|		|	CACCGCCGCCCCGCTATAGGGGCGA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit17	chr3	138666017	138666036	138947175	138947194	3537	hg19					enhancer	FOXL2NB-g2	|		|	CACCGCGCCTTCGCCCCTATAGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit18	chr4	2470767	2470786	2469040	2469059	3538	hg19					enhancer	RNF4-sg1	|		|	CACCGCCTACTCTACTTCCGCGGT	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit19	chr4	2470751	2470770	2469024	2469043	3539	hg19					enhancer	RNF4-sg2	|		|	CACCGTGTCCTTACCCGGCCGACCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit20	chr8	57123885	57123904	56211326	56211345	3540	hg19					enhancer	PLAG1-sg1	|		|	CACCGAGCGGTGGGCGCGACGTCGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-lit21	chr8	57123820	57123839	56211261	56211280	3541	hg19					enhancer	PLAG1-sg2	|		|	CACCGGGCAGCGCATACACTACAA	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3542	hg19	N/A	enh7580	N/A	Enhatls127849	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	25131				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3543	hg19	N/A	N/A	N/A	Enhatls127849	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	24821				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3544	hg19	N/A	enh35907	N/A	Enhatls127849	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	18276				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3545	hg19	N/A	N/A	N/A	Enhatls127849	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	9908				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3546	hg19	N/A	enh88780	N/A	Enhatls127849	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	9036				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3547	hg19	N/A	enh88780	N/A	N/A	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	5786				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3548	hg19	N/A	enh88780	N/A	Enhatls127850	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	5751				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3549	hg19	N/A	N/A	N/A	Enhatls127850	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	2301				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3550	hg19	N/A	enh116213	N/A	Enhatls127850	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	1986				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119480	chr3	138634889	138934908	138916047	139216066	3551	hg19	N/A	enh116213	N/A	N/A	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-119481	chr3	138634889	138934908	138916047	139216066	3552	hg19	N/A	N/A	N/A	Enhatls127851	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2NB	chr3	138947216	138953990	119				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7610
enhrx-119481	chr3	138634889	138934908	138916047	139216066	3553	hg19	N/A	enh45527	N/A	Enhatls127851	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2NB	chr3	138947216	138953990	15742				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7610
enhrx-119481	chr3	138634889	138934908	138916047	139216066	3554	hg19	N/A	N/A	N/A	Enhatls127851	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2NB	chr3	138947216	138953990	20398				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7610
enhrx-119481	chr3	138634889	138934908	138916047	139216066	3555	hg19	N/A	enh95636	N/A	Enhatls127851	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRR23A	chr3	139003961	139006268	22009				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7610
enhrx-119481	chr3	138634889	138934908	138916047	139216066	3556	hg19	N/A	N/A	N/A	Enhatls127851	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					PRR23A	chr3	139003961	139006268	4				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7610
enhrx-119482	chr3	138634889	138934908	138916047	139216066	3557	hg19	N/A	N/A	N/A	Enhatls127852	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7611
enhrx-119483	chr3	138634889	138934908	138916047	139216066	3558	hg19	N/A	N/A	N/A	Enhatls127853	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7612
enhrx-119484	chr3	138634889	138934908	138916047	139216066	3559	hg19	N/A	N/A	N/A	Enhatls127854	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7613
enhrx-119484	chr3	138634889	138934908	138916047	139216066	3560	hg19	N/A	enh105394	N/A	Enhatls127854	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7613
enhrx-119484	chr3	138634889	138934908	138916047	139216066	3561	hg19	N/A	N/A	N/A	Enhatls127854	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7613
enhrx-119484	chr3	138634889	138934908	138916047	139216066	3562	hg19	N/A	N/A	fant13634	Enhatls127854	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7613
enhrx-119484	chr3	138634889	138934908	138916047	139216066	3563	hg19	N/A	N/A	N/A	Enhatls127854	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7613
enhrx-119485	chr3	138634889	138934908	138916047	139216066	3564	hg19	N/A	N/A	N/A	Enhatls127855	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7614
enhrx-119486	chr3	138634889	138934908	138916047	139216066	3565	hg19	N/A	N/A	N/A	Enhatls127856	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7615
enhrx-119486	chr3	138634889	138934908	138916047	139216066	3566	hg19	N/A	enh20979	N/A	Enhatls127856	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7615
enhrx-119486	chr3	138634889	138934908	138916047	139216066	3567	hg19	N/A	enh20979	N/A	N/A	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7615
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3568	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3569	hg19	N/A	enh95117	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3570	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3571	hg19	N/A	enh91474	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3572	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3573	hg19	N/A	enh95118	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3574	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3575	hg19	N/A	enh100100	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3576	hg19	N/A	enh100100	fant13635	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3577	hg19	N/A	enh100100	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3578	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3579	hg19	N/A	enh86496	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3580	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3581	hg19	N/A	N/A	fant13636	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119487	chr3	138634889	138934908	138916047	139216066	3582	hg19	N/A	N/A	N/A	Enhatls127857	enhancer	eFOX1	|		|	CACCGACTCGCCCATACCGCGCCCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					MRPS22	chr3	139005805	139360497	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7616
enhrx-119480	chr3	138634875	138634894	138916033	138916052	3583	hg19	N/A	enh7580	N/A	Enhatls127849	enhancer	eFOX2	|		|	CACCGTACGCGCAAGCCCTCGGGCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FOXL2	chr3	138944223	138947137	25131				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	7609
enhrx-122845	chr4	2537618	2537637	2535891	2535910	3584	hg19	N/A	N/A	N/A	Enhatls131450	enhancer	eRFN5	|		|	CACCGAGGCCCGGTCCAAGATTCGC	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					RNF4	chr4	2462219	2515857	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	389
enhrx-122845	chr4	2538360	2538379	2536633	2536652	3585	hg19	N/A	N/A	fant14945	Enhatls131450	enhancer	eRNF6	|		|	CACCGAGGGATCCCAGTTTACGTCG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA					FAM193A	chr4	2536646	2732573	0				CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	389
enhrx-lit22	chr17	7590827	7590846	7687509	7687528	3586	hg19					enhancer	TP53	|		|	CACCGCCAGTCTTGAGCACATGGG	"knockout of super-enhancers resulted in significant dysregulation of oncogenic gene expression, leading to reduced proliferation and migration of ovarian cancer cells."	Ovary	NIH:OVCAR-3 (OVCAR3)	BRD4	direct	Significant	NA													CRISPRi	A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer	https://doi.org/10.1038/s41467-022-31919-8	35869079	
enhrx-103156	chr20	30183179	30183198	31595376	31595395	3587	hg38	N/A	enh19571	N/A	Enhatls110289	enhancer	E1_up_stream	|		|	CACCGCAGCCTCCTGCCGGGTTTGG	Enhancer knockout down-regulated ID1 expression level and cell proliferation of CRC Cells in vitro and in vivo. 	Intestinal stem cell tissue	CRC cell line	ID1	direct	Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	STAT3-Mediated Promoter-Enhancer Interaction Up-Regulates Inhibitor of DNA Binding 1 (ID1) to Promote Colon Cancer Progression	https://doi.org/10.3390/ijms241210041	37373188	1584
enhrx-103156	chr20	30184873	30184892	31597070	31597089	3588	hg38	N/A	enh19571	N/A	Enhatls110289	enhancer	E1_down_stream	|		|	CACCGCCAGAGGAGGCACCCTGGA	Enhancer knockout down-regulated ID1 expression level and cell proliferation of CRC Cells in vitro and in vivo. 	Intestinal stem cell tissue	CRC cell line	ID1	direct	Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	STAT3-Mediated Promoter-Enhancer Interaction Up-Regulates Inhibitor of DNA Binding 1 (ID1) to Promote Colon Cancer Progression	https://doi.org/10.3390/ijms241210041	37373188	1584
enhrx-8859	chr1	110419006	110419025	109876384	109876403	3589	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer KO gRNA-1 (Upstream) Top	|		|	CACCGTACTACACTCAGGACTCCGT	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110419006	110419025	109876384	109876403	3590	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer KO gRNA-1 (Upstream) Bottom	|		|	AAACACGGAGTCCTGAGTGTAGTAC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110421124	110421143	109878502	109878521	3591	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer KO gRNA-2 (Downstream) Top	|		|	CACCGGTACCCCCAAATCTGGTAC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110421124	110421143	109878502	109878521	3592	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer KO gRNA-2 (Downstream) Bottom	|		|	AAACGTACCAGATTTGGGGGTACC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420118	110420137	109877496	109877515	3593	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 1 Top	|		|	CACCGAGTACTTTCGAATTCCGTTC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420118	110420137	109877496	109877515	3594	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 1 Bottom	|		|	AAACGAACGGAATTCGAAAGTACTC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420452	110420471	109877830	109877849	3595	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 2 Top	|		|	CACCGCAGGTCTTATTCCCTATCCG	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420452	110420472	109877830	109877850	3596	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 2 Bottom	|		|	AAACCGGATAGGGAATAAGACCTGC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420466	110420485	109877844	109877863	3597	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 3 Top	|		|	CACCGCCAAGGCAGACCCCGGATA	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420465	110420485	109877843	109877863	3598	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 3 Bottom	|		|	AAACTATCCGGGGTCTGCCTTGGC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420144	110420163	109877522	109877541	3599	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 4 Top	|		|	CACCGGCAGCGCGCCCTACTCAGG	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-8859	chr1	110420144	110420163	109877522	109877541	3600	hg38	N/A	enh12129	N/A	Enhatls9563	enhancer	CSF1 enhancer CRISPRi sgRNA 4 Bottom	|		|	AAACCCTGAGTAGGGCGCGCTGCC	"Knockout of the CSF1 enhancer leads to reduced cell proliferation, migration, and colony formation."	Breast	TNBC cell line	CSF1	direct	Significant	NA					CSF1	chr1	109910241	109930992	23408				CRISPR-Cas9	Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer	https://doi.org/10.3390/cancers14071852	35406623	8858
enhrx-lit23	chrX	133594193	133594213	134460163	134460183	3601	hg38					enhancer	HPRT1_TSS_sgRNA 1	|		|	GTCGCAGCCGCCTGAAGCTG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit24	chrX	133594227	133594246	134460197	134460216	3602	hg38					enhancer	HPRT1_TSS_sgRNA 2	|		|	AACCTCTCGGCTTTCCCGCG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-90662	chr2	47630086	47630105	47402947	47402966	3603	hg38	N/A	enh5495	N/A	N/A	enhancer	MSH2_TSS_sgRNA 1	|		|	ATGCCTGCGCCTAGGTCGCG	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH2	direct	Significant	NA					MSH2	chr2	47403066	47567156	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2588
enhrx-90662	chr2	47630114	47630133	47402975	47402994	3604	hg38	N/A	enh5495	N/A	N/A	enhancer	MSH2_TSS_sgRNA 2	|		|	GCTAAAGTCACCAGCGTGCG	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH2	direct	Significant	NA					MSH2	chr2	47403066	47567156	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2588
enhrx-lit25	chr2	48010205	48010224	47783066	47783085	3605	hg38					enhancer	MSH6_TSS_sgRNA 1	|		|	CGCACCGCCCGCGCACGGCG	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit26	chr2	48010245	48010264	47783106	47783125	3606	hg38					enhancer	MSH6_TSS_sgRNA 2	|		|	CGGAGGAACCCGGGCCCCAG	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit27	chr3	37034739	37034758	36993248	36993267	3607	hg38					enhancer	MLH1_TSS_sgRNA 1	|		|	GGTTCGTTTTTAGGAGCTCG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MLH1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit28	chr3	37034794	37034813	36993303	36993322	3608	hg38					enhancer	MLH1_TSS_sgRNA 2	|		|	GCGCATATCCTTCTAGGTAG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MLH1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit29	chr7	6048830	6048849	6009199	6009218	3609	hg38					enhancer	PMS2_TSS_sgRNA 1	|		|	TTCGTGACGTCAAAGAGCCT	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit30	chr7	6048712	6048732	6009081	6009101	3610	hg38					enhancer	PMS2_TSS_sgRNA 2	|		|	TCCGCCTCCTGAACTCCCAT	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit31	chr20	5107270	5107289	5126624	5126643	3611	hg38					enhancer	PCNA_TSS_sgRNA 1	|		|	TGGGAGCTCCCGCTTAACCG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit32	chr20	5107327	5107346	5126681	5126700	3612	hg38					enhancer	PCNA_TSS_sgRNA 2	|		|	TTGGACGGCAGCGTCAGGGG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-176405	chrX	133507533	133507552	134373503	134373522	3613	hg38	N/A	enh116277	N/A	Enhatls188626	enhancer	HPRT1_sgRNA_N19	|		|	CTCCCCGGCGGGAGAAGACA	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	direct	Significant	NA					PHF6	chrX	134373287	134428791	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	6122
enhrx-176420	chrX	133684019	133684038	134549989	134550008	3614	hg38	N/A	enh26441	N/A	N/A	enhancer	HPRT1_sgRNA_N20	|		|	CCAGAGGACCCGTGAGCGTG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	direct	Significant	NA					PLAC1	chrX	134565837	134658471	14128	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	6137
enhrx-lit33	chrX	134166200	134166219	135032170	135032189	3615	hg38					enhancer	HPRT1_sgRNA_N21	|		|	GGGTATACACTGGCGAAGAG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit34	chrX	134232737	134232756	135098707	135098726	3616	hg38					enhancer	HPRT1_sgRNA_N22	|		|	CGGCGGGGCGCGCTAGTGTT	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	HPRT1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-113617	chr3	38040831	38040850	37999340	37999359	3617	hg38	N/A	enh7120	N/A	N/A	enhancer	MLH1_sgRNA_N12	|		|	TAAATCGATTCATGTAAAGC	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	MLH1	direct	Significant	NA					VILL	chr3	37988058	38007188	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	1746
enhrx-lit35	chr3	37901953	37901972	37860462	37860481	3618	hg38					enhancer	MLH1_sgRNA_N31	|		|	TGCGCGCGCAACCTAGCAGG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MLH1	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-113631	chr3	38066866	38066885	38025375	38025394	3619	hg38	N/A	enh90178	N/A	N/A	enhancer	MLH1_sgRNA_N32	|		|	GAGGTGGATGGCAGTCTAGC	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MLH1	indirect	weak Significant	NA					PLCD1	chr3	38007495	38029642	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	1760
enhrx-lit36	chr20	5094066	5094085	5113420	5113439	3620	hg38					enhancer	PCNA_sgRNA_N9	|		|	GTCCTGAGGCTCGACGGACT	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit37	chr20	5986734	5986753	6006088	6006107	3621	hg38					enhancer	PCNA_sgRNA_N10	|		|	CCTGTATAAGTGGAGTGTGC	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-102087	chr20	4741730	4741749	4761084	4761103	3622	hg38	N/A	enh6256	N/A	Enhatls109156	enhancer	PCNA_sgRNA_N29	|		|	CTAGAGTTTGCGTGCGTGAG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	direct	Significant	NA					RASSF2	chr20	4780022	4823608	18372	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	515
enhrx-102099	chr20	4803787	4803806	4823141	4823160	3623	hg38	N/A	N/A	N/A	Enhatls109168	enhancer	PCNA_sgRNA_N30	|		|	AGAGACAGGCGAGGATTACG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PCNA 	indirect	weak Significant	NA					RASSF2	chr20	4780022	4823608	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	527
enhrx-147681	chr7	5609015	5609034	5569384	5569403	3624	hg38	N/A	N/A	N/A	Enhatls157820	enhancer	PMS2_sgRNA_N16	|		|	CAGGACCTCAAGCAGGCATG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	direct	Significant	NA					ACTB	chr7	5526408	5563902	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	493
enhrx-lit38	chr7	6388314	6388333	6348683	6348702	3625	hg38					enhancer	PMS2_sgRNA_N17	|		|	TGCAGAAGACCCCATAGGAG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-147681	chr7	5596044	5596063	5556413	5556432	3626	hg38	N/A	enh9580	fant25489	Enhatls157820	enhancer	PMS2_sgRNA_N33	|		|	GCGCCGTTTGCCTTTTATGG	Perturbation of strong enhancers caused an average of 21% reduction in target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	direct	Significant	NA					ACTB	chr7	5526408	5563902	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	493
enhrx-147828	chr7	6543728	6543747	6504097	6504116	3627	hg38	N/A	N/A	N/A	Enhatls157978	enhancer	PMS2_sgRNA_N34	|		|	GCTACTGGAGGAACTCTAGA	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	indirect	weak Significant	NA					GRID2IP	chr7	6496777	6551461	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	640
enhrx-lit39	chr7	5553733	5553752	5514102	5514121	3628	hg38					enhancer	PMS2_sgRNA_N36	|		|	GAGGCGACGCTATTCCATGA	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	PMS2	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-90701	chr2	48338791	48338810	48111652	48111671	3629	hg38	N/A	enh18549	N/A	Enhatls97181	enhancer	MSH2_sgRNA_N26	|		|	CATTCCCAGGATTCCGGCAG	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH2	indirect	weak Significant	NA					FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2627
enhrx-lit40	chr2	48667816	48667835	48440677	48440696	3630	hg38					enhancer	MSH2_sgRNA_N28	|		|	GGCTACGCACGCACGTATTC	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH2	indirect	weak Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-90632	chr2	47213589	47213608	46986450	46986469	3631	hg38	N/A	enh5493	N/A	Enhatls97100	enhancer	MSH2_sgRNA_N35	|		|	CGTGGAGTGACCGTCCCAGA	Knockout of weak enhancers caused a 6% reduction in target gene expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH2	indirect	weak Significant	NA					TTC7A	chr2	46916156	47076123	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2558
enhrx-90701	chr2	48338791	48338810	48111652	48111671	3632	hg38	N/A	enh18549	N/A	Enhatls97181	enhancer	MSH6_sgRNA_N26	|		|	CATTCCCAGGATTCCGGCAG	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	direct	Significant	NA					FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2627
enhrx-lit41	chr2	48667816	48667835	48440677	48440696	3633	hg38					enhancer	MSH6_sgRNA_N28	|		|	GGCTACGCACGCACGTATTC	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-90632	chr2	47213589	47213608	46986450	46986469	3634	hg38	N/A	enh5493	N/A	Enhatls97100	enhancer	MSH6_sgRNA_N35	|		|	CGTGGAGTGACCGTCCCAGA	Knockout of enhancer-like promoters near MSH6 significantly reduced its expression.	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	direct	Significant	NA					TTC7A	chr2	46916156	47076123	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2558
enhrx-176467	chrX	134380467	134380486	135246520	135246539	3635	hg38	N/A	N/A	N/A	Enhatls188690	enhancer	Control sgRNA 1	|		|	CTCTTCCCCTTACTCTGTCT	knockout did not result in any effect for control	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	No result	Non Significant	NA					ETDA	chrX	135252060	135253583	3508	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	6184
enhrx-113511	chr3	36935210	36935229	36893719	36893738	3636	hg38	N/A	N/A	N/A	Enhatls121454	enhancer	Control sgRNA 2	|		|	CTTAGATCTGTTAGCATACC	knockout did not result in any effect for control	Human induced pluripotent stem cell	WTC11 iPSCs	MSH6	No result	Non Significant	NA					TRANK1	chr3	36826818	36945057	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	1640
enhrx-lit42	chr2	46926195	46926214	46699056	46699075	3637	hg38					enhancer	SOCS5_sgRNA 1	|		|	ATTCCTAGCGGCCAATCCGG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	SOCS5	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit43	chr2	46926303	46926322	46699164	46699183	3638	hg38					enhancer	SOCS5_sgRNA 2	|		|	AGAATGGAAAATACCTCCCG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	SOCS5	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-90702	chr2	48542270	48542289	48315131	48315150	3639	hg38	N/A	enh5512	fant7014	Enhatls97182	enhancer	FOXN2_sgRNA 1	|		|	AGAGACGACACCCCTCGCCG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	FOXN2	direct	Significant	NA					FOXN2	chr2	48314636	48379295	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2628
enhrx-90702	chr2	48542472	48542491	48315333	48315352	3640	hg38	N/A	enh5512	fant7014	Enhatls97182	enhancer	FOXN2_sgRNA 2	|		|	CCGCCAAGTAGTGCACGGGG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	FOXN2	direct	Significant	NA					FOXN2	chr2	48314636	48379295	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	2628
enhrx-lit44	chr20	5093813	5093832	5113167	5113186	3641	hg38					enhancer	TMEM230_sgRNA 1	|		|	TACCGAGTGTCACCTGCAGG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	TMEM230	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-lit45	chr20	5093926	5093945	5113280	5113299	3642	hg38					enhancer	TMEM230_sgRNA 2	|		|	TAGGTGCTCGCCCGCCACAG	knockout resulted in downregulation of target gene expression	Human induced pluripotent stem cell	WTC11 iPSCs	TMEM230	direct	Significant	NA										|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	
enhrx-176467	chrX	134380467	134380486	135246520	135246539	3643	hg38	N/A	N/A	N/A	Enhatls188690	enhancer	Control sgRNA 1	|		|	CTCTTCCCCTTACTCTGTCT	knockout did not result in any effect for control	Human induced pluripotent stem cell	WTC11 iPSCs	TMEM230	No result	Non Significant	NA					ETDA	chrX	135252060	135253583	3508	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	6184
enhrx-113511	chr3	36935210	36935229	36893719	36893738	3644	hg38	N/A	N/A	N/A	Enhatls121454	enhancer	Control sgRNA 2	|		|	CTTAGATCTGTTAGCATACC	knockout did not result in any effect for control	Human induced pluripotent stem cell	WTC11 iPSCs	TMEM230	No result	Non Significant	NA					TRANK1	chr3	36826818	36945057	0	|	|	|	CRISPRi + CRISPRn	Parallel characterization of cis-regulatory elements for multiple genes using CRISPRpath	https://doi.org/10.1126/sciadv.abi4360	34524848	1640
enhrx-107420	chr21	42891414	42891433	41519487	41519506	3645	hg19	N/A	enh53874	N/A	N/A	enhancer	E1_1	|		|	GTAGGGTGATTTCCCCTAGT	The knockout of enhancers impaired the transcription of PRCAT38 and TMPRSS2 and inhibited cell growth and migration.	Prostate tissue	Human prostate cancer cell lines	PRCAT38 and TMPRSS2	direct	Significant	NA					TMPRSS2	chr21	41464299	41531116	0	|	|	|	siRNA	Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer	https://doi.org/10.3390/cells8080864	31405024	1303
enhrx-107420	chr21	42894271	42894290	41522344	41522363	3646	hg19	N/A	enh53874	N/A	N/A	enhancer	E1_2	|		|	GGTGATCAAACATCATCCGA	The knockout of enhancers impaired the transcription of PRCAT38 and TMPRSS2 and inhibited cell growth and migration.	Prostate tissue	Human prostate cancer cell lines	PRCAT38 and TMPRSS3	indirect	Non Significant	NA					TMPRSS2	chr21	41464299	41531116	0	|	|	|	siRNA	Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer	https://doi.org/10.3390/cells8080864	31405024	1303
enhrx-107421	chr21	42897912	42897931	41525985	41526004	3647	hg19	N/A	enh53875	N/A	N/A	enhancer	E2_1-3	|		|	CTGTTTGCGGTGTGAGGCAC	The knockout of enhancers impaired the transcription of PRCAT38 and TMPRSS2 and inhibited cell growth and migration.	Prostate tissue	Human prostate cancer cell lines	PRCAT38 and TMPRSS4	indirect	Non Significant	NA					TMPRSS2	chr21	41464299	41531116	0	|	|	|	siRNA	Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer	https://doi.org/10.3390/cells8080864	31405024	1304
enhrx-107421	chr21	42899321	42899340	41527394	41527413	3648	hg19	N/A	enh53875	N/A	N/A	enhancer	E2_2-2	|		|	CACATGGCAACCCTAGGTAT	The knockout of enhancers impaired the transcription of PRCAT38 and TMPRSS2 and inhibited cell growth and migration.	Prostate tissue	Human prostate cancer cell lines	PRCAT38 and TMPRSS5	indirect	Non Significant	NA					TMPRSS2	chr21	41464299	41531116	0	|	|	|	siRNA	Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer	https://doi.org/10.3390/cells8080864	31405024	1304
enhrx-lit46	chr16	67644800	67644819	67610897	67610916	3649	hg19					enhancer	CTCF	|		|	GAAAGACTTACCAGAGACGC	down-regulates the expression of SNCA	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	CTCF	direct	Significant	NA										|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	
enhrx-lit47	chr19	39880729	39880748	39390089	39390108	3650	hg19					enhancer	PAF1	|		|	GGTGATGAACTTGGGGTCGA	knockout resulted in no expression change of SNCA	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	PAF1	direct	Significant	NA										|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	
enhrx-126736	chr4	90721994	90722013	89800843	89800862	3651	hg19	N/A	enh36811	N/A	Enhatls135567	enhancer	SNCA	|		|	1: GTGCTACTATGATTCACTGA	Knocking out SNCA En-1 significantly reduced its expression by about 20%	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	SNCA 	direct	Significant	NA					SNCA	chr4	89700344	89838315	0	|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	4280
enhrx-126736	chr4	90720755	90720774	89799604	89799623	3652	hg19	N/A	enh36811	N/A	Enhatls135567	enhancer	En-1	|		|	2: GACGTGTGAAGTGATATATG	Knocking out SNCA En-1 significantly reduced its expression by about 20%	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	SNCA 	direct	Significant	NA					SNCA	chr4	89700344	89838315	0	|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	4280
enhrx-126736	chr4	90675876	90675895	89754725	89754744	3653	hg19	N/A	enh21689	N/A	Enhatls135567	enhancer	SNCA	|		|	1: GCCATATTGTGTAGCAACAG	knocking out En-2 drastically repressed 75% of its expression	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	SNCA 	direct	Significant	NA					SNCA	chr4	89700344	89838315	0	|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	4280
enhrx-126736	chr4	90673464	90673483	89752313	89752332	3654	hg19	N/A	enh21689	N/A	Enhatls135567	enhancer	En-2	|		|	2: TCTTGATAGCTTCTAAGTCA	knocking out En-2 drastically repressed 75% of its expression	Human induced pluripotent stem cell	iPSC ( induced pluripotent stem cell )	SNCA 	direct	Significant	NA					SNCA	chr4	89700344	89838315	0	|	|	|	CRISPR-Cas9	Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo	https://doi.org/10.1126/sciadv.abq6324	36417521	4280
enhrx-4607	chr1	40761456	40779536	40295784	40313864	3655	hg19	N/A	N/A	N/A	Enhatls5064	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	1	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4606
enhrx-4608	chr1	40761456	40779536	40295784	40313864	3656	hg19	N/A	N/A	N/A	Enhatls5065	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4607
enhrx-4609	chr1	40761456	40779536	40295784	40313864	3657	hg19	N/A	N/A	N/A	Enhatls5066	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4608
enhrx-4610	chr1	40761456	40779536	40295784	40313864	3658	hg19	N/A	N/A	N/A	Enhatls5067	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4609
enhrx-4611	chr1	40761456	40779536	40295784	40313864	3659	hg19	N/A	N/A	N/A	Enhatls5068	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4610
enhrx-4612	chr1	40761456	40779536	40295784	40313864	3660	hg19	N/A	N/A	N/A	Enhatls5069	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4611
enhrx-4613	chr1	40761456	40779536	40295784	40313864	3661	hg19	N/A	N/A	N/A	Enhatls5070	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4612
enhrx-4614	chr1	40761456	40779536	40295784	40313864	3662	hg19	N/A	N/A	N/A	Enhatls5071	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4613
enhrx-4615	chr1	40761456	40779536	40295784	40313864	3663	hg19	N/A	N/A	N/A	Enhatls5072	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4614
enhrx-4616	chr1	40761456	40779536	40295784	40313864	3664	hg19	N/A	N/A	N/A	Enhatls5073	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4615
enhrx-4617	chr1	40761456	40779536	40295784	40313864	3665	hg19	N/A	N/A	N/A	Enhatls5074	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4616
enhrx-4618	chr1	40761456	40779536	40295784	40313864	3666	hg19	N/A	N/A	N/A	Enhatls5075	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4617
enhrx-4619	chr1	40761456	40779536	40295784	40313864	3667	hg19	N/A	N/A	N/A	Enhatls5076	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4618
enhrx-4620	chr1	40761456	40779536	40295784	40313864	3668	hg19	N/A	N/A	N/A	Enhatls5077	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4619
enhrx-4621	chr1	40761456	40779536	40295784	40313864	3669	hg19	N/A	N/A	N/A	Enhatls5078	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4620
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3670	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3671	hg19	N/A	N/A	fant1317	Enhatls5079	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3672	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4623	chr1	40761456	40779536	40295784	40313864	3673	hg19	N/A	N/A	N/A	Enhatls5080	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4622
enhrx-4624	chr1	40761456	40779536	40295784	40313864	3674	hg19	N/A	N/A	N/A	Enhatls5081	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4623
enhrx-4625	chr1	40761456	40779536	40295784	40313864	3675	hg19	N/A	N/A	N/A	Enhatls5082	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4624
enhrx-4626	chr1	40761456	40779536	40295784	40313864	3676	hg19	N/A	N/A	N/A	Enhatls5083	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4625
enhrx-4627	chr1	40761456	40779536	40295784	40313864	3677	hg19	N/A	N/A	N/A	Enhatls5084	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4626
enhrx-4628	chr1	40761456	40779536	40295784	40313864	3678	hg19	N/A	N/A	N/A	Enhatls5085	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4627
enhrx-4629	chr1	40761456	40779536	40295784	40313864	3679	hg19	N/A	N/A	N/A	Enhatls5086	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4628
enhrx-4630	chr1	40761456	40779536	40295784	40313864	3680	hg19	N/A	N/A	N/A	Enhatls5087	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4629
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3681	hg19	N/A	N/A	N/A	Enhatls5088	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3682	hg19	N/A	N/A	fant1318	Enhatls5088	enhancer	ADAMTS14_E1	|		|	CACCGtggtccatgactcAgccccc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26017488860268					COL9A2	chr1	40300488	40317286	0	|	15760	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-145455	chr6	136931546	136931575	136610408	136610437	3683	hg19	N/A	enh39553	N/A	Enhatls155461	enhancer	ADAMTS7P4_E2	|		|	CACCGgcagggagggtgagtcaatc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.232314242765592					MAP3K5	chr6	136557045	136793097	0	|	2724	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7043
enhrx-104473	chr20	43221700	43221721	44593059	44593080	3684	hg19	N/A	enh19650	N/A	Enhatls111726	enhancer	ADAMTS7P4_E3	|		|	CACCGGTTCAGTCTGACTCATGCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.999417803003999					PKIG	chr20	44531784	44624247	0	|	-751	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2901
enhrx-136917	chr5	153486341	153486362	154106781	154106802	3685	hg19	N/A	enh72064	N/A	Enhatls146314	enhancer	ADORA2A_E4	|		|	CACCGgaatgccacagtgagtcaCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.608561491559855					MFAP3	chr5	154038958	154057450	47940	|	-1048	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6708
enhrx-123108	chr4	5531815	5531836	5530088	5530109	3686	hg19	N/A	N/A	N/A	Enhatls131734	enhancer	AGPAT9_E5	|		|	CACCGACTCAGCAGATGACTCACGG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.85247446865199					EVC2	chr4	5562438	5709548	18058	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	652
enhrx-104903	chr20	46343950	46343971	47715206	47715227	3687	hg19	N/A	enh90096	N/A	Enhatls112164	enhancer	AK5_E6	|		|	CACCGGTTAGATAGCATGACTCAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.52959814285598					SULF2	chr20	47656911	47786616	0	|	20263	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3331
enhrx-54353	chr15	35631801	35631822	35339600	35339621	3688	hg19	N/A	N/A	N/A	Enhatls58537	enhancer	ALG1L13P_E7	|		|	CACCGAGGTCAATGAGTCAGAGGAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.291068525606198					DPH6	chr15	35370879	35546192	12916	|	-51716	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1055
enhrx-178643	chrY	17885841	17885861	15773961	15773981	3689	hg19	N/A	N/A	N/A	Enhatls190926	enhancer	AMPD3_E8	|		|	CACCGtgaggttatggttttgagtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.763345033707143					NLGN4Y	chrY	14522572	14845654	725722	|	-18062	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	957
enhrx-lit48	chr9	33515661	33515681	33515663	33515683	3690	hg19					enhancer	AMPD3_E9	|		|	CACCGCCTCACGATTGGACATGCGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.252324780009723										|	30	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-143956	chr6	106040421	106040441	105592546	105592566	3691	hg19	N/A	enh23450	N/A	Enhatls153832	enhancer	ANKRD2_E10	|		|	CACCGTGACAGCTCTGGTGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.630742166915591					PREP	chr6	105273217	105454062	131191	|	29034	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5544
enhrx-62563	chr16	27699636	27699656	27688315	27688335	3692	hg19	N/A	enh44274	N/A	Enhatls67220	enhancer	AOX2P_E11	|		|	CACCGtactgtgaaggatatgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.371768751887095					KATNIP	chr16	27550143	27780344	0	|	-3100	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2858
enhrx-50965	chr14	72015336	72015356	71548619	71548639	3693	hg19	N/A	N/A	N/A	Enhatls54966	enhancer	ARHGAP22_E12	|		|	CACCGCGTCTTGGAATGACTCAGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.622053940732975					SIPA1L1	chr14	71320475	71741229	0	|	34	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2922
enhrx-29452	chr11	62136756	62136776	62369284	62369304	3694	hg19	N/A	enh47490	N/A	Enhatls32001	enhancer	ARHGAP22_E13	|		|	CACCGgtgggttgtgagtcacagaa	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.75473209046797					ASRGL1	chr11	62337447	62393412	0	|	-7490	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4121
enhrx-27898	chr11	35165966	35165986	35144419	35144439	3695	hg19	N/A	enh13892	fant38341	Enhatls30362	enhancer	ARHGAP24_E14	|		|	CACCGAATAAAGCAGATGACCATTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.35245459020871					CD44	chr11	35138881	35232402	0	|	-8406	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2567
enhrx-13739	chr1	192856741	192856761	192887611	192887631	3696	hg19	N/A	enh67209	N/A	Enhatls15158	enhancer	ARSG_E15	|		|	CACCGCATGTTTCACTGAGTCAGAA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.893359683331664					RGS2	chr1	192809038	192812275	73294	|	18586	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13738
enhrx-6649	chr1	67058065	67058085	66592382	66592402	3697	hg19	N/A	N/A	N/A	Enhatls7244	enhancer	ASS1_E16	|		|	CACCGCAGGTTGGCCATGACTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.297789713482068					SGIP1	chr1	66533266	66751139	0	|	-1842	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6648
enhrx-6127	chr1	56293241	56293261	55827568	55827588	3698	hg19	N/A	enh11889	N/A	Enhatls6671	enhancer	BAALC-AS1_E17	|		|	CACCGATGAGCGTGGCAACCAGATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0385347133261125					USP24	chr1	55066358	55215378	605575	|	-12600	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6126
enhrx-982	chr1	8963440	8963460	8903381	8903401	3699	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	BMPER_E18	|		|	CACCGCACTGCGTATGACTCAGTGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.666956811730923					ENO1	chr1	8860999	8879190	15357	|	54827	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	981
enhrx-lit49	chrY	27935316	27935336	25789169	25789189	3700	hg19					enhancer	C3orf52_E19	|		|	CACCGTGGCTGGGAACTGACTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.77030819482773										|	10751	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-175309	chrX	106504801	106504821	107261571	107261591	3701	hg19	N/A	N/A	N/A	Enhatls187485	enhancer	C5orf66-AS2_E20	|		|	CACCGGGGGCAGGGTAGGGTGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.930511694312087					DNAAF6	chrX	107206610	107244247	11914	|	690	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5026
enhrx-168950	chr9	133322516	133322536	130447129	130447149	3702	hg19	N/A	enh90577	N/A	Enhatls180856	enhancer	CACNA2D3-AS1_E21	|		|	CACCGGCCTTGAGTGACTCACTTGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.446481370325107					ASS1	chr9	130444960	130501274	0	|	19462	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6217
enhrx-152672	chr7	101073846	101073866	101430565	101430585	3703	hg19	N/A	N/A	N/A	Enhatls163160	enhancer	CACNA2D3_E22	|		|	CACCGCCAGCTGTTCCAGTCTGGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0430693655800851					COL26A1	chr7	101362874	101559024	0	|	6968	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5484
enhrx-142139	chr6	53087516	53087536	53222718	53222738	3704	hg19	N/A	N/A	N/A	Enhatls151957	enhancer	CCDC171_E23	|		|	CACCGATTGATGTCTGTGAGTCAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.283790033331181					ELOVL5	chr6	53267397	53349179	37684	|	-78902	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3727
enhrx-113447	chr3	34053661	34053681	34012169	34012189	3705	hg19	N/A	enh7104	N/A	Enhatls121389	enhancer	CD44_E24	|		|	CACCGCACAAAGGAAATTGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.553357272337438					PDCD6IP	chr3	33798570	33869707	128707	|	-4681	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1576
enhrx-88637	chr2	14249886	14249906	14109761	14109781	3706	hg19	N/A	N/A	N/A	Enhatls94965	enhancer	CD82_E25	|		|	CACCGGGGAAGCCCGGGGGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.309272272982466					LRATD1	chr2	14632699	14640041	511160	|	3337	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	563
enhrx-14	chr1	46596	46616	46596	46616	3707	hg19	N/A	N/A	N/A	Enhatls14	enhancer	CDCP1_E26	|		|	CACCGAGGGTTAAATGACTCACTCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.662246199278473					OR4F5	chr1	65418	71585	1396	|	16119	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13
enhrx-83169	chr19	20387546	20387566	20276737	20276757	3708	hg19	N/A	enh5065	N/A	Enhatls89204	enhancer	CFAP45_E27	|		|	CACCGCCGAAAGGAAGTGACTCATC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0182612352582954					ZNF486	chr19	20167213	20200488	69695	|	7867	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4139
enhrx-58767	chr15	85855761	85855781	85312530	85312550	3709	hg19	N/A	enh16392	N/A	Enhatls63281	enhancer	CHRDL1_E28	|		|	CACCGCTTTCCACTGAGTCATTCTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.405056283666352					AKAP13	chr15	85380586	85749358	62237	|	54118	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5469
enhrx-51769	chr14	88490836	88490856	88024492	88024512	3710	hg19	N/A	enh51901	N/A	N/A	enhancer	CNIH3_E29	|		|	CACCGaggcaaaatgactcaaagat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.44697605439434					GPR65	chr14	88005134	88014811	6931	|	-14932	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3726
enhrx-12046	chr1	165061972	165061992	165092735	165092755	3711	hg19	N/A	N/A	N/A	Enhatls13347	enhancer	COA1_E30	|		|	CACCGggacattctgactcagtctg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.172373685757117					LMX1A	chr1	165201866	165356715	89479	|	36234	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	12045
enhrx-11581	chr1	159859902	159859922	159890112	159890132	3712	hg19	N/A	enh79223	fant3368	Enhatls12859	enhancer	COL6A1_E31	|		|	CACCGGCAAGGAGGTGGTGACTCAT	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.85691108989215					CFAP45	chr1	159872363	159900165	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	11580
enhrx-9925	chr1	147661246	147661266	148188969	148188989	3713	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	COL6A3_E32	|		|	CACCGgggttgggatgactcagcct	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.828340949908467					NBPF11	chr1	148102046	148152322	0	|	23497	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-9925	chr1	147661246	147661266	148188969	148188989	3714	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	COL6A3_E32	|		|	CACCGgggttgggatgactcagcct	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.828340949908467					GPR89B	chr1	147928419	147993592	0	|	23497	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-9925	chr1	147661246	147661266	148188969	148188989	3715	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	COL6A3_E32	|		|	CACCGgggttgggatgactcagcct	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.828340949908467					GJA8	chr1	147902794	147909269	0	|	23497	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-9925	chr1	146119414	146119434	148188969	148188989	3716	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	CORO2B_E33	|		|	CACCGgactttaagttgagtcatga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0682011874764828					NBPF11	chr1	148102046	148152322	0	|	-7190	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-9925	chr1	146119414	146119434	148188969	148188989	3717	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	CORO2B_E33	|		|	CACCGgactttaagttgagtcatga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0682011874764828					GPR89B	chr1	147928419	147993592	0	|	-7190	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-9925	chr1	146119414	146119434	148188969	148188989	3718	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	CORO2B_E33	|		|	CACCGgactttaagttgagtcatga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0682011874764828					GJA8	chr1	147902794	147909269	0	|	-7190	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9924
enhrx-3864	chr1	33529269	33529289	33063668	33063688	3719	hg19	N/A	N/A	N/A	Enhatls4287	enhancer	COX6B1P7_E34	|		|	CACCGGTGCCAGGTTGAGTCAGTGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1534505215632					AZIN2	chr1	33081152	33123492	15269	|	-40721	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3863
enhrx-3522	chr1	30182345	30182365	29709498	29709518	3720	hg19	N/A	enh26601	N/A	Enhatls3896	enhancer	CPA5_E35	|		|	CACCGTCGGGGATGAGTGAGTCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.76238867752691					PTPRU	chr1	29236515	29326813	377831	|	6009	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3521
enhrx-2469	chr1	21651143	21651163	21324650	21324670	3721	hg19	N/A	enh110	fant673	Enhatls2743	enhancer	CST4_E36	|		|	CACCGacatgtgctgtgttgactca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					ECE1	chr1	21217246	21345572	0	|	-5883	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2468
enhrx-9048	chr1	112114086	112114105	111571464	111571483	3722	hg19	N/A	enh101137	N/A	Enhatls9763	enhancer	CUBN_E37	|		|	CACCGGGCAGATGAGTCATGCTTCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.890685937234146					RAP1A	chr1	111542217	111716691	0	|	-45338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9047
enhrx-8207	chr1	99931266	99931285	99465710	99465729	3723	hg19	N/A	enh27020	N/A	Enhatls8891	enhancer	CYB5B_E38	|		|	CACCGAACACTGGATGACTCAAGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.235954926919433					PLPPR4	chr1	99264291	99309584	151946	|	6371	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8206
enhrx-5328	chr1	46862346	46862365	46396674	46396693	3724	hg19	N/A	N/A	N/A	Enhatls5836	enhancer	DCANP1_E39	|		|	CACCGACTGGGAAGTGAGTCACAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.41601386979591					FAAH	chr1	46394316	46413845	0	|	8944	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5327
enhrx-4695	chr1	41341611	41341630	40875939	40875958	3725	hg19	N/A	enh11777	N/A	Enhatls5152	enhancer	DGKG_E40	|		|	CACCGCTCTCAGAACACTGACTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.324739219743013					CITED4	chr1	40861053	40862363	5871	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4694
enhrx-11885	chr1	161382290	161382309	161412500	161412519	3726	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	DNAJB6_E41	|		|	CACCGTATAGAACTGACTCAATTTA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.20225714980837					CFAP126	chr1	161364732	161367876	44290	|	16591	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	11884
enhrx-11570	chr1	159818911	159818930	159849121	159849140	3727	hg19	N/A	enh12314	N/A	Enhatls12848	enhancer	DPF3_E42	|		|	CACCGttactggtgaCTCAGACATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.279803087389643					VSIG8	chr1	159854315	159862657	4274	|	10119	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	11569
enhrx-7121	chr1	77977330	77977349	77511645	77511664	3728	hg19	N/A	enh11978	fant2051	Enhatls7730	enhancer	ECE1_E43	|		|	CACCGGGCTGGAGCTGAGCTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.903239763468642					AK5	chr1	77282018	77559966	0	|	20406	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7120
enhrx-6790	chr1	68788930	68788949	68323247	68323266	3729	hg19	N/A	enh26838	N/A	Enhatls7394	enhancer	ENO1P3_E44	|		|	CACCGTAATAATGGGACAATGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.81407809723847					WLS	chr1	68098472	68233120	85200	|	3895	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6789
enhrx-5581	chr1	51414871	51414892	50949199	50949220	3730	hg19	N/A	enh49755	N/A	Enhatls6101	enhancer	ENSG00000180152_E45	|		|	CACCGATGGGCCATGAGTCAAGGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.630414687644659					FAF1	chr1	50437027	50960267	0	|	-26835	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5580
enhrx-3857	chr1	33446907	33446926	32981306	32981325	3731	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	ENSG00000199516_E46	|		|	CACCGGATTGCAACACTGGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.457620888414657					RNF19B	chr1	32936444	32964809	16407	|	-3914	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3856
enhrx-4607	chr1	40761456	40779536	40295784	40313864	3732	hg19	N/A	N/A	N/A	Enhatls5064	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	1	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4606
enhrx-4608	chr1	40761456	40779536	40295784	40313864	3733	hg19	N/A	N/A	N/A	Enhatls5065	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4607
enhrx-4609	chr1	40761456	40779536	40295784	40313864	3734	hg19	N/A	N/A	N/A	Enhatls5066	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4608
enhrx-4610	chr1	40761456	40779536	40295784	40313864	3735	hg19	N/A	N/A	N/A	Enhatls5067	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4609
enhrx-4611	chr1	40761456	40779536	40295784	40313864	3736	hg19	N/A	N/A	N/A	Enhatls5068	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4610
enhrx-4612	chr1	40761456	40779536	40295784	40313864	3737	hg19	N/A	N/A	N/A	Enhatls5069	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4611
enhrx-4613	chr1	40761456	40779536	40295784	40313864	3738	hg19	N/A	N/A	N/A	Enhatls5070	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4612
enhrx-4614	chr1	40761456	40779536	40295784	40313864	3739	hg19	N/A	N/A	N/A	Enhatls5071	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4613
enhrx-4615	chr1	40761456	40779536	40295784	40313864	3740	hg19	N/A	N/A	N/A	Enhatls5072	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4614
enhrx-4616	chr1	40761456	40779536	40295784	40313864	3741	hg19	N/A	N/A	N/A	Enhatls5073	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4615
enhrx-4617	chr1	40761456	40779536	40295784	40313864	3742	hg19	N/A	N/A	N/A	Enhatls5074	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4616
enhrx-4618	chr1	40761456	40779536	40295784	40313864	3743	hg19	N/A	N/A	N/A	Enhatls5075	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4617
enhrx-4619	chr1	40761456	40779536	40295784	40313864	3744	hg19	N/A	N/A	N/A	Enhatls5076	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4618
enhrx-4620	chr1	40761456	40779536	40295784	40313864	3745	hg19	N/A	N/A	N/A	Enhatls5077	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4619
enhrx-4621	chr1	40761456	40779536	40295784	40313864	3746	hg19	N/A	N/A	N/A	Enhatls5078	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4620
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3747	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3748	hg19	N/A	N/A	fant1317	Enhatls5079	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3749	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4623	chr1	40761456	40779536	40295784	40313864	3750	hg19	N/A	N/A	N/A	Enhatls5080	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4622
enhrx-4624	chr1	40761456	40779536	40295784	40313864	3751	hg19	N/A	N/A	N/A	Enhatls5081	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4623
enhrx-4625	chr1	40761456	40779536	40295784	40313864	3752	hg19	N/A	N/A	N/A	Enhatls5082	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4624
enhrx-4626	chr1	40761456	40779536	40295784	40313864	3753	hg19	N/A	N/A	N/A	Enhatls5083	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4625
enhrx-4627	chr1	40761456	40779536	40295784	40313864	3754	hg19	N/A	N/A	N/A	Enhatls5084	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4626
enhrx-4628	chr1	40761456	40779536	40295784	40313864	3755	hg19	N/A	N/A	N/A	Enhatls5085	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4627
enhrx-4629	chr1	40761456	40779536	40295784	40313864	3756	hg19	N/A	N/A	N/A	Enhatls5086	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4628
enhrx-4630	chr1	40761456	40779536	40295784	40313864	3757	hg19	N/A	N/A	N/A	Enhatls5087	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4629
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3758	hg19	N/A	N/A	N/A	Enhatls5088	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3759	hg19	N/A	N/A	fant1318	Enhatls5088	enhancer	ENSG00000200706_E47	|		|	CACCGCATGTGTGACTCAGATAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50074470327549					COL9A2	chr1	40300488	40317286	0	|	-62787	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-145455	chr6	136931546	136931575	136610408	136610437	3760	hg19	N/A	enh39553	N/A	Enhatls155461	enhancer	ENSG00000201847_E48	|		|	CACCGATGAGACACTGAGTCATCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.207744843871004					MAP3K5	chr6	136557045	136793097	0	|	69354	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7043
enhrx-93364	chr2	100033861	100033898	99417399	99417436	3761	hg19	N/A	N/A	N/A	Enhatls99992	enhancer	ENSG00000202438_E49	|		|	CACCGGTGAGATAGAAGAGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.5583807155196					REV1	chr2	99400474	99490017	0	|	-26759	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5290
enhrx-104473	chr20	43221700	43221721	44593059	44593080	3762	hg19	N/A	enh19650	N/A	Enhatls111726	enhancer	ENSG00000206721_E50	|		|	CACCGGGGTGAGTGCAGATGACTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.915682357539881					PKIG	chr20	44531784	44624247	0	|	39761	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2901
enhrx-lit50	chr1	204460237	204460258	204491109	204491130	3763	hg19					enhancer	ENSG00000212161_E51	|		|	CACCGCTCCATATGACTCATGGTCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.628611651688228										|	2703	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-136917	chr5	153486341	153486362	154106781	154106802	3764	hg19	N/A	enh72064	N/A	Enhatls146314	enhancer	ENSG00000212214_E52	|		|	CACCGaagctttatcgtgagtcagc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.34524716967002					MFAP3	chr5	154038958	154057450	47940	|	4883	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6708
enhrx-123108	chr4	5531815	5531836	5530088	5530109	3765	hg19	N/A	N/A	N/A	Enhatls131734	enhancer	ENSG00000216123_E53	|		|	CACCGCTTCCTGTTTCTGAGTCATC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.455470522293676					EVC2	chr4	5562438	5709548	18058	|	6505	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	652
enhrx-104903	chr20	46343950	46343971	47715206	47715227	3766	hg19	N/A	enh90096	N/A	Enhatls112164	enhancer	ENSG00000217644_E54	|		|	CACCGGTCTCGAAACAAATGACTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.629994804428255					SULF2	chr20	47656911	47786616	0	|	-1051	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3331
enhrx-54353	chr15	35631801	35631822	35339600	35339621	3767	hg19	N/A	N/A	N/A	Enhatls58537	enhancer	ENSG00000221029_E55	|		|	CACCGtcctcttttgcattgagtca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.269738155716744					DPH6	chr15	35370879	35546192	12916	|	41037	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1055
enhrx-93248	chr2	99032310	99032330	98415847	98415867	3768	hg19	N/A	N/A	N/A	Enhatls99870	enhancer	ENSG00000221793_E56	|		|	CACCGAGAAATACATGACTCAACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.703913980652126					CNGA3	chr2	98346187	98398601	0	|	-93098	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5174
enhrx-62563	chr16	27699636	27699656	27688315	27688335	3769	hg19	N/A	enh44274	N/A	Enhatls67220	enhancer	ENSG00000223786_E57	|		|	CACCGTTTGATGTCCATCATCTTTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.264507341336423					KATNIP	chr16	27550143	27780344	0	|	-3987	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2858
enhrx-50965	chr14	72015336	72015356	71548619	71548639	3770	hg19	N/A	N/A	N/A	Enhatls54966	enhancer	ENSG00000224132_E58	|		|	CACCGAGCTCTGTGAGTCAGTGCTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.55753664536333					SIPA1L1	chr14	71320475	71741229	0	|	-7518	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2922
enhrx-6127	chr1	56293241	56293261	55827568	55827588	3771	hg19	N/A	enh11889	N/A	Enhatls6671	enhancer	ENSG00000224569_E59	|		|	CACCGATTTTACAGGAATGACTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.255537694100018					USP24	chr1	55066358	55215378	605575	|	69343	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6126
enhrx-982	chr1	8963440	8963460	8903381	8903401	3772	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	ENSG00000224826_E60	|		|	CACCGAGGCATAGGCTCTGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.50875589533848					ENO1	chr1	8860999	8879190	15357	|	21890	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	981
enhrx-175309	chrX	106504801	106504821	107261571	107261591	3773	hg19	N/A	N/A	N/A	Enhatls187485	enhancer	ENSG00000224844_E61	|		|	CACCGAATCAGAGGTGACTCACATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.62280613758118					DNAAF6	chrX	107206610	107244247	11914	|	-59904	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5026
enhrx-152672	chr7	101073846	101073866	101430565	101430585	3774	hg19	N/A	N/A	N/A	Enhatls163160	enhancer	ENSG00000225330_E62	|		|	CACCGCAAGGAAATCATAAAACTAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.12812410130132					COL26A1	chr7	101362874	101559024	0	|	-2913	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5484
enhrx-142139	chr6	53087516	53087536	53222718	53222738	3775	hg19	N/A	N/A	N/A	Enhatls151957	enhancer	ENSG00000225649_E63	|		|	CACCGGGCGCGATGACTCATTTATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.28257393690685					ELOVL5	chr6	53267397	53349179	37684	|	78116	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3727
enhrx-113447	chr3	34053661	34053681	34012169	34012189	3776	hg19	N/A	enh7104	N/A	Enhatls121389	enhancer	ENSG00000225947_E64	|		|	CACCGCCTGTTTGGGATCATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.41432300047354					PDCD6IP	chr3	33798570	33869707	128707	|	-7779	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1576
enhrx-88637	chr2	14249886	14249906	14109761	14109781	3777	hg19	N/A	N/A	N/A	Enhatls94965	enhancer	ENSG00000226087_E65	|		|	CACCGGACCAATCTCATGAGTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.545584671930343					LRATD1	chr2	14632699	14640041	511160	|	-42675	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	563
enhrx-15899	chr1	224499398	224499418	224311696	224311716	3778	hg19	N/A	N/A	N/A	Enhatls17458	enhancer	ENSG00000226320_E66	|		|	CACCGTAAGATTAAATCTGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0740891963301521					NVL	chr1	224227333	224330189	0	|	146698	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15898
enhrx-3522	chr1	30182345	30182365	29709498	29709518	3779	hg19	N/A	enh26601	N/A	Enhatls3896	enhancer	ENSG00000226598_E67	|		|	CACCGTATTGGGTGACTCAGGAGTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.332552493051133					PTPRU	chr1	29236515	29326813	377831	|	25388	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3521
enhrx-lit51	chr2	219158029	219158048	218293306	218293325	3780	hg19					enhancer	ENSG00000227482_E68	|		|	CACCGgagtgcatgtcaagtgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.81150395295343										|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-91518	chr2	69080476	69080495	68853344	68853363	3781	hg19	N/A	enh91279	N/A	Enhatls98071	enhancer	ENSG00000228176_E69	|		|	CACCGTGACCTTGCTGAGTCACTGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.265788548654329					BMP10	chr2	68860908	68871397	5678	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3444
enhrx-8207	chr1	99931266	99931285	99465710	99465729	3782	hg19	N/A	enh27020	N/A	Enhatls8891	enhancer	ENSG00000228235_E70	|		|	CACCGttgtcctcacctggtgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.701259628397898					PLPPR4	chr1	99264291	99309584	151946	|	-738	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8206
enhrx-4695	chr1	41341611	41341630	40875939	40875958	3783	hg19	N/A	enh11777	N/A	Enhatls5152	enhancer	ENSG00000228329_E71	|		|	CACCGGCACATTTGTGAGTCAAATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.183594631943234					CITED4	chr1	40861053	40862363	5871	|	-15843	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4694
enhrx-94926	chr2	130464459	130464478	129706886	129706905	3784	hg19	N/A	N/A	N/A	Enhatls101638	enhancer	ENSG00000228675_E72	|		|	CACCGTGCAGCTGAGTCAGTGGTGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.425373245906585					RAB6C	chr2	129979665	129982738	272254	|	16091	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6852
enhrx-94229	chr2	113382135	113382154	112624558	112624577	3785	hg19	N/A	enh18815	N/A	Enhatls100906	enhancer	ENSG00000229263_E73	|		|	CACCGgacccactgagtcagaagtt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.906814247570059					SLC20A1	chr2	112645938	112663825	18530	|	3530	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6155
enhrx-91435	chr2	67096436	67096455	66869304	66869323	3786	hg19	N/A	enh18622	N/A	Enhatls97980	enhancer	ENSG00000229434_E74	|		|	CACCGCTTTCTATGAGTCATTATTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0608351062377471					MEIS1	chr2	66435124	66573869	286938	|	61350	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3361
enhrx-90653	chr2	47497090	47497109	47269951	47269970	3787	hg19	N/A	enh18543	fant6987	Enhatls97129	enhancer	ENSG00000229528_E75	|		|	CACCGtgaggaaatgactcagacaC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.169603153548516					EPCAM	chr2	47345157	47387020	75066	|	-11691	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2579
enhrx-88634	chr2	13068521	13068540	12928395	12928414	3788	hg19	N/A	enh44702	N/A	Enhatls94957	enhancer	ENSG00000229673_E76	|		|	CACCGagacagagcttcttgactca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.121305458797763					TRIB2	chr2	12716934	12742734	179158	|	70062	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	560
enhrx-11570	chr1	159818911	159818930	159849121	159849140	3789	hg19	N/A	enh12314	N/A	Enhatls12848	enhancer	ENSG00000229694_E77	|		|	CACCGTCTTGAAAAGCCCTGGGAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.51999239330261					VSIG8	chr1	159854315	159862657	4274	|	-226	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	11569
enhrx-5581	chr1	51414871	51414892	50949199	50949220	3790	hg19	N/A	enh49755	N/A	Enhatls6101	enhancer	ENSG00000229976_E78	|		|	CACCGTGAGGAGTCTTTGAGTCAGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1673457369694					FAF1	chr1	50437027	50960267	0	|	-63744	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5580
enhrx-3857	chr1	33446907	33446926	32981306	32981325	3791	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	ENSG00000230355_E79	|		|	CACCGTAATAGTCATGTGAGTCATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.210807017184724					RNF19B	chr1	32936444	32964809	16407	|	11612	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3856
enhrx-15899	chr1	224499398	224730676	224311696	224542974	3792	hg19	N/A	N/A	N/A	Enhatls17458	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15898
enhrx-15900	chr1	224499398	224730676	224311696	224542974	3793	hg19	N/A	N/A	N/A	Enhatls17459	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15899
enhrx-15901	chr1	224499398	224730676	224311696	224542974	3794	hg19	N/A	N/A	N/A	Enhatls17460	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15900
enhrx-15902	chr1	224499398	224730676	224311696	224542974	3795	hg19	N/A	N/A	N/A	Enhatls17461	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15901
enhrx-15903	chr1	224499398	224730676	224311696	224542974	3796	hg19	N/A	N/A	N/A	Enhatls17462	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15902
enhrx-15904	chr1	224499398	224730676	224311696	224542974	3797	hg19	N/A	N/A	fant4993	N/A	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	810	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15903
enhrx-15905	chr1	224499398	224730676	224311696	224542974	3798	hg19	N/A	N/A	N/A	Enhatls17463	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	5098	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15904
enhrx-15905	chr1	224499398	224730676	224311696	224542974	3799	hg19	N/A	N/A	fant4994	Enhatls17463	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					NVL	chr1	224227333	224330189	10900	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15904
enhrx-15905	chr1	224499398	224730676	224311696	224542974	3800	hg19	N/A	N/A	N/A	Enhatls17463	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	5060	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15904
enhrx-15906	chr1	224499398	224730676	224311696	224542974	3801	hg19	N/A	N/A	N/A	Enhatls17464	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15905
enhrx-15907	chr1	224499398	224730676	224311696	224542974	3802	hg19	N/A	N/A	N/A	Enhatls17465	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15906
enhrx-15908	chr1	224499398	224730676	224311696	224542974	3803	hg19	N/A	N/A	N/A	Enhatls17466	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15907
enhrx-15909	chr1	224499398	224730676	224311696	224542974	3804	hg19	N/A	N/A	N/A	Enhatls17467	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15908
enhrx-15910	chr1	224499398	224730676	224311696	224542974	3805	hg19	N/A	N/A	N/A	Enhatls17468	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15909
enhrx-15911	chr1	224499398	224730676	224311696	224542974	3806	hg19	N/A	N/A	N/A	Enhatls17469	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15910
enhrx-15912	chr1	224499398	224730676	224311696	224542974	3807	hg19	N/A	N/A	N/A	Enhatls17470	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15911
enhrx-15912	chr1	224499398	224730676	224311696	224542974	3808	hg19	N/A	enh948	N/A	Enhatls17470	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH4	chr1	224356857	224379452	532	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15911
enhrx-15912	chr1	224499398	224730676	224311696	224542974	3809	hg19	N/A	N/A	N/A	Enhatls17470	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	8	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15911
enhrx-15913	chr1	224499398	224730676	224311696	224542974	3810	hg19	N/A	N/A	N/A	Enhatls17471	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15912
enhrx-15914	chr1	224499398	224730676	224311696	224542974	3811	hg19	N/A	N/A	N/A	Enhatls17472	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15913
enhrx-15915	chr1	224499398	224730676	224311696	224542974	3812	hg19	N/A	N/A	N/A	Enhatls17473	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15914
enhrx-15916	chr1	224499398	224730676	224311696	224542974	3813	hg19	N/A	N/A	N/A	Enhatls17474	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15915
enhrx-15916	chr1	224499398	224730676	224311696	224542974	3814	hg19	N/A	enh27576	N/A	Enhatls17474	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15915
enhrx-15916	chr1	224499398	224730676	224311696	224542974	3815	hg19	N/A	N/A	N/A	Enhatls17474	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15915
enhrx-15916	chr1	224499398	224730676	224311696	224542974	3816	hg19	N/A	N/A	fant4995	Enhatls17474	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15915
enhrx-15916	chr1	224499398	224730676	224311696	224542974	3817	hg19	N/A	N/A	N/A	Enhatls17474	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15915
enhrx-15917	chr1	224499398	224730676	224311696	224542974	3818	hg19	N/A	N/A	N/A	Enhatls17475	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15916
enhrx-15918	chr1	224499398	224730676	224311696	224542974	3819	hg19	N/A	N/A	N/A	Enhatls17476	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15917
enhrx-15919	chr1	224499398	224730676	224311696	224542974	3820	hg19	N/A	N/A	N/A	Enhatls17477	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15918
enhrx-15920	chr1	224499398	224730676	224311696	224542974	3821	hg19	N/A	N/A	N/A	Enhatls17478	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15919
enhrx-15920	chr1	224499398	224730676	224311696	224542974	3822	hg19	N/A	enh79404	N/A	Enhatls17478	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15919
enhrx-15920	chr1	224499398	224730676	224311696	224542974	3823	hg19	N/A	N/A	N/A	Enhatls17478	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15919
enhrx-15921	chr1	224499398	224730676	224311696	224542974	3824	hg19	N/A	N/A	N/A	Enhatls17479	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15920
enhrx-15922	chr1	224499398	224730676	224311696	224542974	3825	hg19	N/A	N/A	N/A	Enhatls17480	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	0	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15921
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3826	hg19	N/A	N/A	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	2266	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3827	hg19	N/A	enh12718	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	8289	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3828	hg19	N/A	enh12718	fant4996	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	10331	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3829	hg19	N/A	enh12718	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	10705	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3830	hg19	N/A	N/A	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	24281	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3831	hg19	N/A	enh61973	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	42115	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3832	hg19	N/A	N/A	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	48501	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3833	hg19	N/A	enh12719	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	54292	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3834	hg19	N/A	enh12719	fant4997	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	61260	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3835	hg19	N/A	enh12719	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	61684	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3836	hg19	N/A	enh12719	fant4998	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	65984	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3837	hg19	N/A	enh12719	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	66320	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3838	hg19	N/A	enh12719	fant4999	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	66458	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3839	hg19	N/A	enh12719	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	66829	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3840	hg19	N/A	N/A	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	76481	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3841	hg19	N/A	enh27577	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					WDR26	chr1	224385145	224437033	85731	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3842	hg19	N/A	N/A	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	77134	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3843	hg19	N/A	enh27578	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	76338	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3844	hg19	N/A	enh27578	fant5000	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	76064	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3845	hg19	N/A	enh27578	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	74986	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3846	hg19	N/A	enh27578	fant5001	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	74663	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3847	hg19	N/A	enh27578	N/A	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	73578	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-15923	chr1	224499398	224730676	224311696	224542974	3848	hg19	N/A	enh27578	fant5002	Enhatls17481	enhancer	ENSG00000230394_E80	|		|	CACCGTATAGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.149540864321679					CNIH3	chr1	224616316	224740554	73034	|	18881	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15922
enhrx-4607	chr1	40761456	40779536	40295784	40313864	3849	hg19	N/A	N/A	N/A	Enhatls5064	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	1	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4606
enhrx-4608	chr1	40761456	40779536	40295784	40313864	3850	hg19	N/A	N/A	N/A	Enhatls5065	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4607
enhrx-4609	chr1	40761456	40779536	40295784	40313864	3851	hg19	N/A	N/A	N/A	Enhatls5066	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4608
enhrx-4610	chr1	40761456	40779536	40295784	40313864	3852	hg19	N/A	N/A	N/A	Enhatls5067	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4609
enhrx-4611	chr1	40761456	40779536	40295784	40313864	3853	hg19	N/A	N/A	N/A	Enhatls5068	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4610
enhrx-4612	chr1	40761456	40779536	40295784	40313864	3854	hg19	N/A	N/A	N/A	Enhatls5069	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4611
enhrx-4613	chr1	40761456	40779536	40295784	40313864	3855	hg19	N/A	N/A	N/A	Enhatls5070	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4612
enhrx-4614	chr1	40761456	40779536	40295784	40313864	3856	hg19	N/A	N/A	N/A	Enhatls5071	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4613
enhrx-4615	chr1	40761456	40779536	40295784	40313864	3857	hg19	N/A	N/A	N/A	Enhatls5072	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4614
enhrx-4616	chr1	40761456	40779536	40295784	40313864	3858	hg19	N/A	N/A	N/A	Enhatls5073	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4615
enhrx-4617	chr1	40761456	40779536	40295784	40313864	3859	hg19	N/A	N/A	N/A	Enhatls5074	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4616
enhrx-4618	chr1	40761456	40779536	40295784	40313864	3860	hg19	N/A	N/A	N/A	Enhatls5075	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4617
enhrx-4619	chr1	40761456	40779536	40295784	40313864	3861	hg19	N/A	N/A	N/A	Enhatls5076	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4618
enhrx-4620	chr1	40761456	40779536	40295784	40313864	3862	hg19	N/A	N/A	N/A	Enhatls5077	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4619
enhrx-4621	chr1	40761456	40779536	40295784	40313864	3863	hg19	N/A	N/A	N/A	Enhatls5078	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4620
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3864	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3865	hg19	N/A	N/A	fant1317	Enhatls5079	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4622	chr1	40761456	40779536	40295784	40313864	3866	hg19	N/A	N/A	N/A	Enhatls5079	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4621
enhrx-4623	chr1	40761456	40779536	40295784	40313864	3867	hg19	N/A	N/A	N/A	Enhatls5080	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4622
enhrx-4624	chr1	40761456	40779536	40295784	40313864	3868	hg19	N/A	N/A	N/A	Enhatls5081	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4623
enhrx-4625	chr1	40761456	40779536	40295784	40313864	3869	hg19	N/A	N/A	N/A	Enhatls5082	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4624
enhrx-4626	chr1	40761456	40779536	40295784	40313864	3870	hg19	N/A	N/A	N/A	Enhatls5083	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4625
enhrx-4627	chr1	40761456	40779536	40295784	40313864	3871	hg19	N/A	N/A	N/A	Enhatls5084	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4626
enhrx-4628	chr1	40761456	40779536	40295784	40313864	3872	hg19	N/A	N/A	N/A	Enhatls5085	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4627
enhrx-4629	chr1	40761456	40779536	40295784	40313864	3873	hg19	N/A	N/A	N/A	Enhatls5086	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4628
enhrx-4630	chr1	40761456	40779536	40295784	40313864	3874	hg19	N/A	N/A	N/A	Enhatls5087	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4629
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3875	hg19	N/A	N/A	N/A	Enhatls5088	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-4631	chr1	40761456	40779536	40295784	40313864	3876	hg19	N/A	N/A	fant1318	Enhatls5088	enhancer	ENSG00000230537_E81	|		|	CACCGAAGTGGGAATGAGTCATGAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.00385501423471					COL9A2	chr1	40300488	40317286	0	|	45769	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4630
enhrx-145455	chr6	136931546	136931575	136610408	136610437	3877	hg19	N/A	enh39553	N/A	Enhatls155461	enhancer	ENSG00000230621_E82	|		|	CACCGATAGGATAGTGACTCAAACC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.000563463499751662					MAP3K5	chr6	136557045	136793097	0	|	-83126	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7043
enhrx-16641	chr1	233792616	233792656	233656870	233656910	3878	hg19	N/A	N/A	N/A	Enhatls18235	enhancer	ENSG00000231185_E83	|		|	CACCGCTCCAGCATGACTCATCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.193523891737465					KCNK1	chr1	233614105	233672514	0	|	-9249	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	16640
enhrx-104473	chr20	43221700	43221721	44593059	44593080	3879	hg19	N/A	enh19650	N/A	Enhatls111726	enhancer	ENSG00000231747_E84	|		|	CACCGAAGTGAAGGCGTGACTCACC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.33622237205738					PKIG	chr20	44531784	44624247	0	|	-2149	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2901
enhrx-lit52	chr1	204460237	204460258	204491109	204491130	3880	hg19					enhancer	ENSG00000231873_E85	|		|	CACCGggcatgtaagtgagtcatgt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.03115484344111										|	-61970	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-136917	chr5	153486341	153486362	154106781	154106802	3881	hg19	N/A	enh72064	N/A	Enhatls146314	enhancer	ENSG00000232200_E86	|		|	CACCGTGAAGCTGACTCAAGTCTCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0252719723072577					MFAP3	chr5	154038958	154057450	47940	|	-18819	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6708
enhrx-123993	chr4	34623750	34623771	34622128	34622149	3882	hg19	N/A	N/A	N/A	Enhatls132692	enhancer	ENSG00000232208_E87	|		|	CACCGcaggtgtgagtcaccatgtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.575283905749264					ARAP2	chr4	36066003	36244514	1347321	|	3819	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1537
enhrx-123108	chr4	5531815	5531836	5530088	5530109	3883	hg19	N/A	N/A	N/A	Enhatls131734	enhancer	ENSG00000233147_E88	|		|	CACCGAAAGGTTATGACTCATTTGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.428611115799819					EVC2	chr4	5562438	5709548	18058	|	-3547	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	652
enhrx-104903	chr20	46343950	46343971	47715206	47715227	3884	hg19	N/A	enh90096	N/A	Enhatls112164	enhancer	ENSG00000233219_E89	|		|	CACCGGAAGAGCGGAGGAAAGGAAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.855216391665779					SULF2	chr20	47656911	47786616	0	|	18754	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3331
enhrx-54353	chr15	35631801	35631822	35339600	35339621	3885	hg19	N/A	N/A	N/A	Enhatls58537	enhancer	ENSG00000233287_E90	|		|	CACCGTAATGAGTGAGGTGAGTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.480321789039201					DPH6	chr15	35370879	35546192	12916	|	-1602	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1055
enhrx-143956	chr6	106040421	106040441	105592546	105592566	3886	hg19	N/A	enh23450	N/A	Enhatls153832	enhancer	ENSG00000233983_E91	|		|	CACCGcataaggccatgagtcatat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.376216432589459					PREP	chr6	105273217	105454062	131191	|	-805	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5544
enhrx-93248	chr2	99032310	99032330	98415847	98415867	3887	hg19	N/A	N/A	N/A	Enhatls99870	enhancer	ENSG00000234263_E92	|		|	CACCGCTCCCTCCCTTCTTCTGAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.408281230375248					CNGA3	chr2	98346187	98398601	0	|	18658	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5174
enhrx-62563	chr16	27699636	27699656	27688315	27688335	3888	hg19	N/A	enh44274	N/A	Enhatls67220	enhancer	ENSG00000234634_E93	|		|	CACCGattggaatgagtcaggatgg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0638611774621026					KATNIP	chr16	27550143	27780344	0	|	-40611	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2858
enhrx-50965	chr14	72015336	72015356	71548619	71548639	3889	hg19	N/A	N/A	N/A	Enhatls54966	enhancer	ENSG00000234693_E94	|		|	CACCGGGACTGCTGAGTCAACCCTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0148364510876917					SIPA1L1	chr14	71320475	71741229	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2922
enhrx-13739	chr1	192856741	192856761	192887611	192887631	3890	hg19	N/A	enh67209	N/A	Enhatls15158	enhancer	ENSG00000235886_E95	|		|	CACCGAGGGGATGACTCAGTTACTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.19579693127333					RGS2	chr1	192809038	192812275	73294	|	-89896	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13738
enhrx-6127	chr1	56293241	56293261	55827568	55827588	3891	hg19	N/A	enh11889	N/A	Enhatls6671	enhancer	ENSG00000236559_E96	|		|	CACCGTGAGTCTGAGTCATTTCCTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.622430938875215					USP24	chr1	55066358	55215378	605575	|	-9814	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6126
enhrx-982	chr1	8963440	8963460	8903381	8903401	3892	hg19	N/A	enh11478	N/A	Enhatls1056	enhancer	ENSG00000236572_E97	|		|	CACCGACATGGTGGTTGAGTCAATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.258563893087335					ENO1	chr1	8860999	8879190	15357	|	-35248	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	981
enhrx-175309	chrX	106504801	106504821	107261571	107261591	3893	hg19	N/A	N/A	N/A	Enhatls187485	enhancer	ENSG00000236724_E98	|		|	CACCGAATTCCTGGCTGACTCATCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.977481141411863					DNAAF6	chrX	107206610	107244247	11914	|	12085	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5026
enhrx-158372	chr8	39917256	39917276	40059737	40059757	3894	hg19	N/A	enh40926	N/A	Enhatls169205	enhancer	ENSG00000236914_E99	|		|	CACCGTACAATTATGAGTCAATCCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.21304397543725					IDO2	chr8	39934650	40016392	41215	|	2554	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2163
enhrx-157430	chr8	24076426	24076446	24218913	24218933	3895	hg19	N/A	enh24849	fant28987	Enhatls168190	enhancer	ENSG00000236921_E100	|		|	CACCGGTCAGTGGGCATGAGTCATC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.1726256683954					ADAM28	chr8	24294068	24359014	74954	|	-23263	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1221
enhrx-152672	chr7	101073846	101073866	101430565	101430585	3896	hg19	N/A	N/A	N/A	Enhatls163160	enhancer	ENSG00000236992_E101	|		|	CACCGtcaggatgagtcaaccttat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.524882711003569					COL26A1	chr7	101362874	101559024	0	|	-6544	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5484
enhrx-142139	chr6	53087516	53087536	53222718	53222738	3897	hg19	N/A	N/A	N/A	Enhatls151957	enhancer	ENSG00000237567_E102	|		|	CACCGCAGGTTACTGGGAGTGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.106778353688913					ELOVL5	chr6	53267397	53349179	37684	|	39190	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3727
enhrx-88637	chr2	14249886	14249906	14109761	14109781	3898	hg19	N/A	N/A	N/A	Enhatls94965	enhancer	ENSG00000237576_E103	|		|	CACCGTCTTGATGCTGAGTCAGACA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.861786986671745					LRATD1	chr2	14632699	14640041	511160	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	563
enhrx-50785	chr14	69162366	69162386	68695649	68695669	3899	hg19	N/A	enh3300	N/A	Enhatls54769	enhancer	ENSG00000238160_E104	|		|	CACCGAGCCAGTGACTCAGCTCCTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.779176202048233					RAD51B	chr14	67819778	68730218	0	|	-173	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2742
enhrx-91518	chr2	69058950	69058969	68831818	68831837	3900	hg19	N/A	enh5634	N/A	Enhatls98071	enhancer	ENSG00000238282_E105	|		|	CACCGtatgctaatgaggtgactca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					ARHGAP25	chr2	68734810	68826833	2881	|	-33111	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3444
enhrx-9048	chr1	112114086	112114105	111571464	111571483	3901	hg19	N/A	enh101137	N/A	Enhatls9763	enhancer	ENSG00000238644_E106	|		|	CACCGTCTCTTTCTTGAGTCACCTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.67768648442603					RAP1A	chr1	111542217	111716691	0	|	14884	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9047
enhrx-8207	chr1	99931266	99931285	99465710	99465729	3902	hg19	N/A	enh27020	N/A	Enhatls8891	enhancer	ENSG00000239991_E107	|		|	CACCGCGCCACTGGCCATGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.108178234890678					PLPPR4	chr1	99264291	99309584	151946	|	15009	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8206
enhrx-90150	chr2	38006842	38006861	37779699	37779718	3903	hg19	N/A	enh18450	fant6611	Enhatls96565	enhancer	ENSG00000240854_E108	|		|	CACCGCTCTCTCCATGACTCATTTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.17609696585311					CDC42EP3	chr2	37641881	37738468	41059	|	38989	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2076
enhrx-90148	chr2	37668347	37668366	37441204	37441223	3904	hg19	N/A	N/A	N/A	Enhatls96563	enhancer	ENSG00000241439_E109	|		|	CACCGCCCCAGACAGTGTGACTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.172808159889569					QPCT	chr2	37342826	37373322	44996	|	7026	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2074
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3905	hg19	N/A	enh35408	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	124322	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3906	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	132151	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3907	hg19	N/A	enh61055	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	142133	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3908	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	150186	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3909	hg19	N/A	enh100028	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	152521	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3910	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	156671	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3911	hg19	N/A	enh88732	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	167821	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3912	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	171971	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3913	hg19	N/A	enh20631	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	172661	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3914	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	176811	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3915	hg19	N/A	enh102709	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					CACNA2D3	chr3	54122551	55074557	190670	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3916	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	180392	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3917	hg19	N/A	N/A	fant12171	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	179980	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3918	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	161638	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3919	hg19	N/A	enh100029	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	157488	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3920	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	156428	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3921	hg19	N/A	enh100030	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	149388	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3922	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	145258	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3923	hg19	N/A	enh100031	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	140868	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-115787	chr3	55236568	55361348	55202540	55327320	3924	hg19	N/A	N/A	N/A	Enhatls123882	enhancer	ENSG00000242568_E110	|		|	CACCGttggcctgggttgactcatg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.49369225494687					WNT5A	chr3	55465714	55489945	138298	|	23338	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3916
enhrx-157849	chr8	29370930	29370960	29513413	29513443	3925	hg19	N/A	enh24890	N/A	Enhatls168631	enhancer	ENSG00000242611_E111	|		|	CACCGGGTGGGTGAGTCACAGCTGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.618368157668577					DUSP4	chr8	29333063	29350684	158145	|	-12122	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1640
enhrx-123993	chr4	34623750	34623771	34622128	34622149	3926	hg19	N/A	N/A	N/A	Enhatls132692	enhancer	ENSG00000242941_E112	|		|	CACCGGAGTGGAAGAGCGCTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.777908232568968					ARAP2	chr4	36066003	36244514	1347321	|	-2177	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1537
enhrx-113592	chr3	37598350	37598373	37556859	37556882	3927	hg19	N/A	enh20499	N/A	Enhatls121544	enhancer	ENSG00000243572_E113	|		|	CACCGGAGAAAATCCATGACTCATA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.190869769183105					ITGA9	chr3	37452114	37823507	0	|	-24135	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1721
enhrx-158372	chr8	39898647	39898667	40041128	40041148	3928	hg19	N/A	enh24942	N/A	Enhatls169205	enhancer	ENSG00000243777_E114	|		|	CACCGTGTTCCAGAATGAGTCAGAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.658830223429616					IDO2	chr8	39934650	40016392	21657	|	27192	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2163
enhrx-158372	chr8	39917256	39917276	40059737	40059757	3929	hg19	N/A	enh40926	N/A	Enhatls169205	enhancer	ENSG00000244063_E115	|		|	CACCGcctgggtgatgagtcagagt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.114993586121963					IDO2	chr8	39934650	40016392	41215	|	12237	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2163
enhrx-157430	chr8	24076426	24076446	24218913	24218933	3930	hg19	N/A	enh24849	fant28987	Enhatls168190	enhancer	ENSG00000248482_E116	|		|	CACCGTGTGATATGACTCATTGAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.510321259259046					ADAM28	chr8	24294068	24359014	74954	|	-8387	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1221
enhrx-128404	chr4	141021402	141021421	140100248	140100267	3931	hg19	N/A	enh8235	fant16951	Enhatls137303	enhancer	ENSG00000250698_E117	|		|	CACCGGTGGAGGCTTGAGTCAGCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.6074806457661					MAML3	chr4	139716752	140154184	0	|	27565	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5948
enhrx-50785	chr14	69162366	69162386	68695649	68695669	3932	hg19	N/A	enh3300	N/A	Enhatls54769	enhancer	ENSG00000250748_E118	|		|	CACCGactgtgttctgactcatctg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.530266353616806					RAD51B	chr14	67819778	68730218	0	|	43038	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2742
enhrx-31930	chr11	86399505	86399525	86688463	86688483	3933	hg19	N/A	enh14167	N/A	Enhatls34690	enhancer	ENSG00000253067_E119	|		|	CACCGAAGACACTGAGTCAGGACAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.19863619607795					ME3	chr11	86441107	86672618	12595	|	-14560	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6599
enhrx-170569	chrX	3181105	3181124	3263064	3263083	3934	hg19	N/A	enh42351	N/A	Enhatls182522	enhancer	ENSG00000253141_E120	|		|	CACCGATGCATGGTGACTCATGAAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.16752421904106					MXRA5	chrX	3308564	3346652	43238	|	-2432	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	286
enhrx-158372	chr8	39917256	39917276	40059737	40059757	3935	hg19	N/A	enh40926	N/A	Enhatls169205	enhancer	ENSG00000253381_E121	|		|	CACCGTACTAATCAGTGACTCAGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.99419798198825					IDO2	chr8	39934650	40016392	41215	|	44013	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2163
enhrx-148629	chr7	26387193	26387212	26347573	26347592	3936	hg19	N/A	enh9675	N/A	Enhatls158844	enhancer	ENSG00000253632_E122	|		|	CACCGCCTAGCTCATCTCCTCTTAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.271360216851598					SNX10	chr7	26291861	26374383	0	|	13472	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1441
enhrx-147188	chr7	89542	89561	89542	89561	3937	hg19	N/A	enh39826	fant25235	Enhatls157300	enhancer	ENSG00000253790_E123	|		|	CACCGAGTTAAGTGGTTTGACTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.433323321790958					FAM20C	chr7	192570	260772	102730	|	-41674	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	0
enhrx-157430	chr8	24076426	24076446	24218913	24218933	3938	hg19	N/A	enh24849	fant28987	Enhatls168190	enhancer	ENSG00000253891_E124	|		|	CACCGAAATGAAGCTGTATGCATTA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.86766654201476					ADAM28	chr8	24294068	24359014	74954	|	-41288	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1221
enhrx-159822	chr8	82139767	82139786	81227532	81227551	3939	hg19	N/A	enh41159	N/A	Enhatls170723	enhancer	ENSG00000254014_E125	|		|	CACCGgaaaaggaaatgagtcatgg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.880472404230408					FABP5	chr8	81280535	81284777	46117	|	16309	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3613
enhrx-159820	chr8	81962995	81963014	81050760	81050779	3940	hg19	N/A	enh10405	fant30007	Enhatls170721	enhancer	ENSG00000254177_E126	|		|	CACCGAGGTGCTTGAGTCCATCAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.588226791930293					PAG1	chr8	80967809	81112068	0	|	7294	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3611
enhrx-161660	chr8	130710687	130710706	129698441	129698460	3941	hg19	N/A	enh41579	N/A	Enhatls172677	enhancer	ENSG00000254223_E127	|		|	CACCGTTATGATCATGACTCATGAT	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	3.12194905419538					GSDMC	chr8	129748195	129786624	48007	|	-14378	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5451
enhrx-114209	chr3	44996756	44996775	44955264	44955283	3942	hg19	N/A	enh7170	N/A	Enhatls122211	enhancer	ENSG00000254645_E128	|		|	CACCGTGGGAAATGACTCACAGATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.854031160808918					ZDHHC3	chr3	44915256	44976185	0	|	41786	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2338
enhrx-31930	chr11	86399505	86399524	86688463	86688482	3943	hg19	N/A	enh14167	N/A	Enhatls34690	enhancer	ENSG00000254731_E129	|		|	CACCGtagggctggcaaatgactca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.259393445109935					ME3	chr11	86441107	86672618	12595	|	14123	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6599
enhrx-27896	chr11	35099335	35099354	35077788	35077807	3944	hg19	N/A	enh13891	fant38332	Enhatls30359	enhancer	ENSG00000255521_E130	|		|	CACCGACCTTCTTAAAGTGACTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.47417273449754					CD44	chr11	35138881	35232402	60469	|	59702	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2565
enhrx-19133	chr10	30085088	30085107	29796159	29796178	3945	hg19	N/A	enh27956	N/A	Enhatls20913	enhancer	ENSG00000256001_E131	|		|	CACCGcatcactgactcatcccact	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.204557961341567					SVIL	chr10	29457337	29736959	51278	|	19561	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1568
enhrx-43955	chr12	127760290	127760309	127275745	127275764	3946	hg19	N/A	enh30051	N/A	Enhatls47457	enhancer	ENSG00000256292_E132	|		|	CACCGatggtggagaaactgagtca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.067035013659896					TMEM132C	chr12	128267169	128707911	990880	|	8333	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9265
enhrx-159820	chr8	81962995	81963014	81050760	81050779	3947	hg19	N/A	enh10405	fant30007	Enhatls170721	enhancer	ENSG00000256568_E133	|		|	CACCGGGAAGGGTAAGTGAGTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.08116066644159					PAG1	chr8	80967809	81112068	0	|	-9020	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3611
enhrx-150142	chr7	62495494	62495513	63035116	63035135	3948	hg19	N/A	N/A	N/A	Enhatls160490	enhancer	ENSG00000257629_E134	|		|	CACCGAGATGGCTAGTGAGTCAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.316691457956871					ZNF722	chr7	63998848	64018081	848845	|	-110414	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2954
enhrx-138675	chr6	6245197	6245216	6244964	6244983	3949	hg19	N/A	enh55622	N/A	Enhatls148254	enhancer	ENSG00000257807_E135	|		|	CACCGGAAGAAGCCAGGCATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.51561545557647					F13A1	chr6	6144083	6321013	0	|	-20456	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	263
enhrx-137697	chr5	173982076	173982095	174555073	174555092	3950	hg19	N/A	enh22839	N/A	Enhatls147175	enhancer	ENSG00000258091_E136	|		|	CACCGgaaaggacagtgtgactcag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.359777501952706					MSX2	chr5	174724581	174730896	163903	|	100038	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7488
enhrx-137670	chr5	172899423	172899442	173472420	173472439	3951	hg19	N/A	enh22824	fant20899	Enhatls147138	enhancer	ENSG00000258231_E137	|		|	CACCGtcaggcatgagtcatggtgc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.462425050348307					BOD1	chr5	173607144	173616653	134604	|	13841	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7461
enhrx-135591	chr5	134475744	134475763	135140054	135140073	3952	hg19	N/A	enh8707	fant19887	Enhatls144849	enhancer	ENSG00000258245_E138	|		|	CACCGCGTCTATTGAGTCACATGTG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	3.47718474359782					PITX1	chr5	135027733	135034813	105100	|	28534	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5382
enhrx-133315	chr5	76562334	76562353	77266509	77266528	3953	hg19	N/A	enh97690	fant18961	Enhatls142435	enhancer	ENSG00000258623_E139	|		|	CACCGagggaagtgactcagtgtcc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.414353927575145					PDE8B	chr5	77086731	77427124	0	|	9732	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3106
enhrx-133315	chr5	76562334	76562353	77266509	77266528	3954	hg19	N/A	enh97690	fant18961	Enhatls142435	enhancer	ENSG00000258623_E139	|		|	CACCGagggaagtgactcagtgtcc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.414353927575145					PDE8B	chr5	77210448	77428256	0	|	9732	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3106
enhrx-49228	chr14	38878478	38878774	38409274	38409570	3955	hg19	N/A	enh30825	N/A	Enhatls53128	enhancer	ENSG00000258808_E140	|		|	CACCGGGAGTGGTAAATTCTGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.13239885044					CLEC14A	chr14	38253999	38256093	150427	|	-1784	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1185
enhrx-13518	chr1	185343166	185343305	185374034	185374173	3956	hg19	N/A	enh50099	fant3997	Enhatls14928	enhancer	ENSG00000258871_E141	|		|	CACCGTCAGGGGCGATGAGTCAGTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.749007616977767					IVNS1ABP	chr1	185296387	185317243	56712	|	-20427	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13517
enhrx-lit53	chr17	73911059	73911097	75914978	75915016	3957	hg19					enhancer	ENSG00000258976_E142	|		|	CACCGAGTGACACACGGTGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.594343175587078										|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-51274	chr14	75083375	75083395	74616672	74616692	3958	hg19	N/A	enh15771	N/A	N/A	enhancer	ENSG00000259072_E143	|		|	CACCGattggtttgactcattgttt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.57783748323435					LTBP2	chr14	74498182	74612237	2300	|	-117775	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3231
enhrx-49682	chr14	51865890	51865910	51399172	51399192	3959	hg19	N/A	enh15601	fant45970	Enhatls53604	enhancer	ENSG00000259178_E144	|		|	CACCGGAGCAGTTGTGGGATGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.00037890335838					FRMD6	chr14	51489136	51730727	89872	|	4980	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1639
enhrx-56046	chr15	52369344	52369363	52077147	52077166	3960	hg19	N/A	enh31381	fant48207	Enhatls60295	enhancer	ENSG00000259354_E145	|		|	CACCGTTGTCCCTGAGTCACTGCCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.70521994109942					MAPK6	chr15	51971821	52067375	9707	|	17	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2748
enhrx-64505	chr16	64195376	64195395	64161472	64161491	3961	hg19	N/A	enh4065	N/A	Enhatls69232	enhancer	ENSG00000259354_E146	|		|	CACCGAGGCCTTGGAGGCATGAGGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0190236721414562					CDH11	chr16	64943752	65122365	778262	|	2075	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4800
enhrx-55572	chr15	45740457	45740476	45448259	45448278	3962	hg19	N/A	N/A	N/A	Enhatls59791	enhancer	ENSG00000259834_E147	|		|	CACCGGGATTAGCCATGACTCAAAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.65926757379716					C15orf48	chr15	45430578	45448761	0	|	10732	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2274
enhrx-51004	chr14	73082443	73082462	72615735	72615754	3963	hg19	N/A	enh15753	N/A	Enhatls55006	enhancer	ENSG00000260715_E148	|		|	CACCGTGCTCATTTGTGAGTCAAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.660756623027743					DPF3	chr14	72609033	72894101	0	|	-5958	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2961
enhrx-8955	chr1	111188910	111188929	110646288	110646307	3964	hg19	N/A	enh61886	N/A	Enhatls9659	enhancer	ENSG00000261024_E149	|		|	CACCGCCTGCCATCCTGTGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.25592072441768					KCNA2	chr1	110593579	110631474	14353	|	-38653	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8954
enhrx-141703	chr6	45623723	45623742	45655986	45656005	3965	hg19	N/A	enh9140	N/A	Enhatls151501	enhancer	ENSG00000261080_E150	|		|	CACCGTTGGGATCAGATTGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.04832453649488					RUNX2	chr6	45328316	45664349	0	|	-78958	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3291
enhrx-66353	chr16	88276501	88276520	88242895	88242914	3966	hg19	N/A	enh32027	N/A	Enhatls71251	enhancer	ENSG00000261273_E151	|		|	CACCGAGCTGGGAAACCATGAGTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					ZNF469	chr16	88382958	88440757	133210	|	-7725	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6648
enhrx-61059	chr16	9162465	9162484	9068608	9068627	3967	hg19	N/A	enh16524	N/A	Enhatls65636	enhancer	ENSG00000261392_E152	|		|	CACCGGTGATGAcatgtggtgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.488064096914896					HAPSTR1	chr16	9091643	9121635	14415	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1354
enhrx-171522	chrX	24263491	24263510	24245374	24245393	3968	hg19	N/A	enh11163	N/A	Enhatls183551	enhancer	ENSG00000264184_E153	|		|	CACCGGTGAGGGTGACTCACTCCTC	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.63910076866982					ZFX	chrX	24149628	24216255	28907	|	40762	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1239
enhrx-31336	chr11	74571921	74572288	74860876	74861243	3969	hg19	N/A	N/A	N/A	Enhatls34059	enhancer	ENSG00000264746_E154	|		|	CACCGaaactcaggtgtgactcaag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1534505215632					XRRA1	chr11	74840229	74949187	0	|	13430	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6005
enhrx-78797	chr18	71356367	71356386	73689132	73689151	3970	hg19	N/A	enh32826	N/A	Enhatls84539	enhancer	ENSG00000265380_E155	|		|	CACCGCTAAATGGTCAAGTGAGTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.176532765426226					FBXO15	chr18	74073367	74147843	379928	|	25957	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2815
enhrx-141590	chr6	44009470	44009489	44041733	44041752	3971	hg19	N/A	enh9138	fant22700	Enhatls151369	enhancer	ENSG00000265518_E156	|		|	CACCGGGAATCCCTGACTCATCGCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.656980045841357					MRPL14	chr6	44113450	44127452	71435	|	-28593	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3178
enhrx-167671	chr9	119742243	119742262	116979964	116979983	3972	hg19	N/A	enh85517	N/A	Enhatls179456	enhancer	ENSG00000265662_E157	|		|	CACCGTTAATGATCCATTCTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.465120270407996					ASTN2	chr9	116423111	117415070	0	|	118796	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4938
enhrx-45096	chr13	31205502	31205922	30631365	30631785	3973	hg19	N/A	N/A	N/A	Enhatls48659	enhancer	ENSG00000266421_E158	|		|	CACCGtaggcatgagtcaccattcc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.344774729633341					USPL1	chr13	30617919	30660770	0	|	-22581	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	718
enhrx-45079	chr13	30607899	30607923	30033762	30033786	3974	hg19	N/A	enh30160	N/A	Enhatls48633	enhancer	ENSG00000266505_E159	|		|	CACCGgggatgcttaacaatgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.279169038371255					KATNAL1	chr13	30202629	30307551	160932	|	-9775	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	701
enhrx-77759	chr18	43344465	43344484	45764500	45764519	3975	hg19	N/A	enh4818	N/A	Enhatls83432	enhancer	ENSG00000267193_E160	|		|	CACCGATGTTTCTTGACTCACGGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.01178617301928					SLC14A1	chr18	45724126	45752520	11823	|	-16722	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1777
enhrx-77759	chr18	43382940	43382959	45802975	45802994	3976	hg19	N/A	enh4820	fant55009	Enhatls83432	enhancer	ENSG00000267558_E161	|		|	CACCGCAGGAGATACTGACTCATGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.31666983673486					EPG5	chr18	45800580	45967329	0	|	-14211	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1777
enhrx-83414	chr19	31705170	31705189	31214264	31214283	3977	hg19	N/A	enh32923	fant56758	Enhatls89462	enhancer	ENSG00000267777_E162	|		|	CACCGAGAGGCTGCATGAGTCACTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.591504115347323					TSHZ3	chr19	31274944	31349436	60531	|	-46545	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4384
enhrx-66260	chr16	86426547	86426566	86392941	86392960	3978	hg19	N/A	enh31988	N/A	Enhatls71136	enhancer	ENSG00000268473_E163	|		|	CACCGACAGCATCTCTCTGACTCag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.491421129895796					FOXF1	chr16	86510526	86515422	116869	|	42568	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6555
enhrx-93788	chr2	108979032	108979051	108362576	108362595	3979	hg19	N/A	enh44854	N/A	Enhatls100448	enhancer	ENSG00000271070_E164	|		|	CACCGgagtcagctggtaatgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0118802080299977					SULT1C4	chr2	108377953	108388989	11855	|	4391	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5714
enhrx-157425	chr8	23654576	23654595	23797063	23797082	3980	hg19	N/A	enh40823	N/A	Enhatls168185	enhancer	ENSG00000271118_E165	|		|	CACCGGTCAGTGTGTGAGTCAGTAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.532210309794513					STC1	chr8	23841928	23854806	43443	|	8813	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1216
enhrx-171787	chrX	34576150	34576169	34558033	34558052	3981	hg19	N/A	enh73915	N/A	Enhatls183820	enhancer	ENSG00000271136_E166	|		|	CACCGtctgcagtggttgagtCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.57832790496455					TMEM47	chrX	34627074	34657285	61017	|	-40845	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1504
enhrx-136476	chr5	148292838	148292858	148913275	148913295	3982	hg19	N/A	enh22690	fant20301	Enhatls145798	enhancer	ENSG00000272411_E167	|		|	CACCGCACTCCTGCCTGACTCATTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0516233795367806					SH3TC2	chr5	148982149	149063089	68809	|	56691	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6267
enhrx-15065	chr1	207880859	207880878	207707514	207707533	3983	hg19	N/A	enh110672	N/A	Enhatls16575	enhancer	ENSG00000274059_E168	|		|	CACCGgccactcaggaggatgagtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.631793048473043					CR1L	chr1	207645132	207723703	0	|	936	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15064
enhrx-101710	chr20	1396817	1396836	1416173	1416192	3984	hg19	N/A	enh19436	fant57695	Enhatls108773	enhancer	ENSG00000274322_E169	|		|	CACCGagcctggaagacctcagtct	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.39368062738576					FKBP1A	chr20	1368977	1393164	22878	|	-22783	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	138
enhrx-116111	chr3	61663548	61663567	61677874	61677893	3985	hg19	N/A	enh45428	N/A	Enhatls124243	enhancer	ENSG00000274718_E170	|		|	CACCGgaggggaagggaagtgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.460535997443216					PTPRG	chr3	61561570	62297609	0	|	-13492	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4240
enhrx-167623	chr9	118436077	118436097	115673798	115673818	3986	hg19	N/A	enh42234	fant33446	Enhatls179397	enhancer	ENSG00000274755_E171	|		|	CACCGccaatgaccatgagtcacag	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.18702087857489					PAPPA	chr9	116153790	116402321	479871	|	60168	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4890
enhrx-lit54	chr14	71371545	71371564	70904828	70904847	3987	hg19					enhancer	ENSG00000274818_E172	|		|	CACCGCAATGACTGAGTCAGTCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.75910622208673										|	1955	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-42805	chr12	115358904	115358923	114921099	114921118	3988	hg19	N/A	enh15017	N/A	Enhatls46225	enhancer	ENSG00000274879_E173	|		|	CACCGGGAACTCTGAGTCAAGAGGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.41999269089894					TBX3	chr12	114670254	114684175	232675	|	8720	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8115
enhrx-47564	chr13	108103306	108103325	107450958	107450977	3989	hg19	N/A	enh30676	fant45183	Enhatls51360	enhancer	ENSG00000276740_E174	|		|	CACCGTGGGGTGTGAGTCACAGCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.524968088420616					NALF1	chr13	107163509	107867496	0	|	15348	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3186
enhrx-72923	chr17	55558369	55558389	57481008	57481028	3990	hg19	N/A	enh4488	N/A	Enhatls78278	enhancer	ENSG00000278285_E175	|		|	CACCGATTTCAGTGACTCATAGTAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.04392736970305					MSI2	chr17	57255850	57684689	0	|	7221	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6192
enhrx-172326	chrX	47236528	47236547	47377129	47377148	3991	hg19	N/A	N/A	N/A	Enhatls184375	enhancer	ENSG00000278651_E176	|		|	CACCGcctgtgctgagtcagttcct	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					ZNF157	chrX	47370577	47414498	0	|	-26133	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2043
enhrx-130720	chr5	10705222	10705241	10705110	10705129	3992	hg19	N/A	enh8382	N/A	Enhatls139734	enhancer	ENSG00000278865_E177	|		|	CACCGtggggctctgagtcatctta	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.95560497735041					DAP	chr5	10679229	10761234	0	|	-28360	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	511
enhrx-78797	chr18	71612460	71612479	73945225	73945244	3993	hg19	N/A	enh32833	N/A	Enhatls84539	enhancer	ENSG00000278902_E178	|		|	CACCGTCCTCTCAGGGCAATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0799201104924213					FBXO15	chr18	74073367	74147843	122648	|	-22216	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2815
enhrx-107752	chr21	45613174	45613193	44193291	44193310	3994	hg19	N/A	enh20024	N/A	Enhatls115237	enhancer	ENSG00000279687_E179	|		|	CACCGcgcctgctgtgttgagtcat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.294594311625367					GATD3	chr21	44133609	44210114	0	|	-4311	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1635
enhrx-157849	chr8	29449635	29449654	29592119	29592138	3995	hg19	N/A	enh10215	N/A	Enhatls168631	enhancer	ENSG00000280147_E180	|		|	CACCGGTTGGGGTACAGCAAACATC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.58902519597043					DUSP4	chr8	29333063	29350684	226826	|	-4918	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1640
enhrx-157849	chr8	29464742	29464761	29607226	29607245	3996	hg19	N/A	enh10216	N/A	Enhatls168631	enhancer	ENSG00000280487_E181	|		|	CACCGGAGTAATTGACTCAAAAAGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.22702563130745					DUSP4	chr8	29333063	29350684	253086	|	19114	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1640
enhrx-112359	chr3	10247486	10247505	10205802	10205821	3997	hg19	N/A	enh45328	N/A	Enhatls120224	enhancer	ENSG00000280637_E182	|		|	CACCGccgtcaggtgactcatagtg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.816043612411939					IRAK2	chr3	10164918	10243745	0	|	11274	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	488
enhrx-41150	chr12	96842303	96842322	96448525	96448544	3998	hg19	N/A	enh14922	fant42801	Enhatls44479	enhancer	ENSG00000280856_E183	|		|	CACCGTTTCCTGTGACTCACAGTCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.02676874614235					CFAP54	chr12	96489576	96875555	40938	|	-4922	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6460
enhrx-7833	chr1	92496587	92496606	92031030	92031049	3999	hg19	N/A	N/A	fant2353	Enhatls8472	enhancer	EPHX4_E184	|		|	CACCGAGGCCTGTGAGTCAGACTGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.05027680407214					EPHX4	chr1	92029984	92063538	0	|	-777	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7832
enhrx-144273	chr6	111167008	111167303	110845805	110846100	4000	hg19	N/A	N/A	N/A	Enhatls154189	enhancer	ERBB4_E185	|		|	CACCGattaaggagtattgactcac	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.158480905388527					CDK19	chr6	110609977	110815637	15040	|	71929	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5861
enhrx-125769	chr4	75240501	75240521	74374784	74374804	4001	hg19	N/A	enh36722	N/A	Enhatls134551	enhancer	EREG_E186	|		|	CACCGaagtggtgccagtgactcag	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.394214458386					EREG	chr4	74365144	74388749	0	|	7490	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3313
enhrx-lit55	chr4	5755639	5755658	5753912	5753931	4002	hg19					enhancer	EVC_E187	|		|	CACCGTGACCCGGAAAAGTTTCTCG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.000667246240769079										|	-1155	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-lit56	chr9	130341431	130341450	127579152	127579171	4003	hg19					enhancer	FAM129B_E188	|		|	CACCGCAGCTGGTGACTCAGAGCCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.00050627133108										|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-93694	chr2	106071681	106071701	105455224	105455244	4004	hg19	N/A	enh18780	N/A	Enhatls100340	enhancer	FAM9B_E189	|		|	CACCGGGAGATTTACTGACTCATCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0815382813695623					FHL2	chr2	105357711	105438513	14266	|	9315	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5620
enhrx-170715	chrX	9121300	9121319	9153259	9153278	4005	hg19	N/A	enh26136	N/A	Enhatls182680	enhancer	FHL2_E190	|		|	CACCGAACTAATGACTCATGTTGCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0826990487227658					FAM9B	chrX	9024231	9295682	0	|	-16404	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	432
enhrx-lit57	chr9	130341431	130341450	127579152	127579171	4006	hg19					enhancer	FILIP1L_E191	|		|	CACCGTGGAAAGCTGAGTCATAGCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.14811417340285										|	-1936	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-77531	chr18	33215394	33215414	35635430	35635450	4007	hg19	N/A	enh32596	N/A	Enhatls83188	enhancer	FRMD6_E192	|		|	CACCGCTGTAATGCATGAGTCACAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.138750252670449					GALNT1	chr18	35581739	35711834	0	|	6746	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1549
enhrx-49683	chr14	52014146	52014166	51547428	51547448	4008	hg19	N/A	enh15604	fant45976	Enhatls53607	enhancer	GALNT15_E193	|		|	CACCGGTACTTTTTCTGCATGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.16006173338724					FRMD6	chr14	51489136	51730727	0	|	27123	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1640
enhrx-116928	chr3	99597017	99597036	99878173	99878192	4009	hg19	N/A	enh65712	fant12768	N/A	enhancer	GALNT1_E194	|		|	CACCGTATGCTCCAGGCAGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.52988204534527					CMSS1	chr3	99817836	100181732	0	|	-7767	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5057
enhrx-116928	chr3	99597017	99597036	99878173	99878192	4010	hg19	N/A	enh65712	fant12768	N/A	enhancer	GALNT1_E194	|		|	CACCGTATGCTCCAGGCAGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.52988204534527					FILIP1L	chr3	99828810	100114513	0	|	-7767	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5057
enhrx-112862	chr3	16188875	16188894	16147368	16147387	4011	hg19	N/A	enh20384	N/A	Enhatls120765	enhancer	GLI3_E195	|		|	CACCGGATCCATTCTGACTCAGAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.791312916345461					GALNT15	chr3	16174679	16231992	20692	|	56137	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	991
enhrx-149366	chr7	41961146	41961165	41921548	41921567	4012	hg19	N/A	enh24149	N/A	Enhatls159650	enhancer	GLRX_E196	|		|	CACCGAGCCAGATTCTGAGTCACGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.690958719038472					GLI3	chr7	41960948	42264100	37312	|	-1132	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2178
enhrx-31481	chr11	76411738	76411769	76700694	76700725	4013	hg19	N/A	enh14107	N/A	Enhatls34216	enhancer	GUCY2EP_E197	|		|	CACCGTGGAGGAAGACATAAGGCCG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.459589033993554					LRRC32	chr11	76657523	76670747	26380	|	3707	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6150
enhrx-22085	chr10	93100835	93100854	91341078	91341097	4014	hg19	N/A	enh13397	N/A	Enhatls24292	enhancer	HECTD2_E198	|		|	CACCGTTAGACACAGGCTGACTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.175179522181552					PCGF5	chr10	91163011	91284337	53452	|	68254	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4520
enhrx-98093	chr2	192067073	192067093	191202347	191202367	4015	hg19	N/A	enh19099	fant9602	Enhatls104949	enhancer	HMGB1P27_E199	|		|	CACCGAATTCTGTGAGTCAATGCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.127261857061208					MYO1B	chr2	191245184	191425389	42697	|	-27917	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	10019
enhrx-123815	chr4	24772008	24772027	24770386	24770405	4016	hg19	N/A	enh21400	N/A	Enhatls132502	enhancer	HNRNPA1P65_E200	|		|	CACCGTGGGACTGCTGTGAGTCAGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.86389114154069					SOD3	chr4	24789911	24800842	5499	|	823	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1359
enhrx-13188	chr1	181081750	181081769	181112614	181112633	4017	hg19	N/A	enh12430	fant3854	Enhatls14557	enhancer	IER5_E201	|		|	CACCGGGCCAGATGACTCAGGGGTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.170741672622842					IER5	chr1	181088699	181092900	19655	|	-23748	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13187
enhrx-145503	chr6	137555050	137555069	137233913	137233932	4018	hg19	N/A	enh23656	N/A	Enhatls155518	enhancer	IFNGR1_E202	|		|	CACCGcccaagccaggtgactcagt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0592303915921351					IFNGR1	chr6	137197482	137219449	4985	|	-14417	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7091
enhrx-149364	chr7	41550974	41550993	41511376	41511395	4019	hg19	N/A	N/A	N/A	Enhatls159643	enhancer	INHBA_E203	|		|	CACCGCAGCAGAGTCATATTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.971786269995985					INHBA	chr7	41685113	41705834	172227	|	180788	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2176
enhrx-lit58	chr7	30791031	30791050	30751415	30751434	4020	hg19					enhancer	INHBA_E204	|		|	CACCGAACAGAACATCTGAGTCAAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.887702821682249										|	1531	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-145503	chr6	137555050	137555069	137233913	137233932	4021	hg19	N/A	enh23656	N/A	Enhatls155518	enhancer	INMT_E205	|		|	CACCGggagtagccaggtgagtcag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.382869722617564					IFNGR1	chr6	137197482	137219449	4985	|	514	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7091
enhrx-13188	chr1	181081750	181081769	181112614	181112633	4022	hg19	N/A	enh12430	fant3854	Enhatls14557	enhancer	INSC_E206	|		|	CACCGACTGAGGAAGTGACTCACAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.987567199801804					IER5	chr1	181088699	181092900	19655	|	4223	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13187
enhrx-112357	chr3	10215164	10215183	10173480	10173499	4023	hg19	N/A	enh20317	N/A	Enhatls120222	enhancer	INSC_E207	|		|	CACCGgagtaagtgagtcagAGGGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.156546962034408					IRAK2	chr3	10164918	10243745	0	|	-8790	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	486
enhrx-112357	chr3	10215164	10215183	10173480	10173499	4024	hg19	N/A	enh20317	fant11119	Enhatls120222	enhancer	INSC_E207	|		|	CACCGgagtaagtgagtcagAGGGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.156546962034408					IRAK2	chr3	10164918	10243745	0	|	-8790	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	486
enhrx-57309	chr15	68644911	68644930	68352573	68352592	4025	hg19	N/A	enh31465	fant48635	Enhatls61657	enhancer	IQCJ-SCHIP1_E208	|		|	CACCGCTGACCTTTTGTATGTACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.345566657555389					ITGA11	chr15	68296531	68432163	0	|	-100088	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4011
enhrx-26867	chr11	15145563	15145582	15124017	15124036	4026	hg19	N/A	enh43499	N/A	Enhatls29288	enhancer	IRAK2_E209	|		|	CACCGGAGGGGATGAGTCACTACCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.596148108719171					INSC	chr11	15112423	15247208	0	|	-8010	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1536
enhrx-lit59	chr11	15129449	15129468	15107903	15107922	4027	hg19					enhancer	ITGA11_E210	|		|	CACCGGTCTGGATGCTGAGTCACCC	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	3.24538150645473										|	8818	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-120398	chr3	158887765	158887784	159169976	159169995	4028	hg19	N/A	enh36038	fant14010	Enhatls128825	enhancer	ITGB6_E211	|		|	CACCGCTGTGGTCGGGAGATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.44894814605035					IQCJ-SCHIP1	chr3	159069251	159897629	0	|	-7674	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8527
enhrx-120398	chr3	158887765	158887784	159169976	159169995	4029	hg19	N/A	enh36038	fant14010	Enhatls128825	enhancer	ITGB6_E211	|		|	CACCGCTGTGGTCGGGAGATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.44894814605035					IQCJ	chr3	159069318	159266307	0	|	-7674	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8527
enhrx-107193	chr21	39551794	39551822	38179700	38179728	4030	hg19	N/A	enh19949	N/A	Enhatls114624	enhancer	KAL1_E212	|		|	CACCGTATGGGTATTTTGAGTCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.301202625312187					KCNJ15	chr21	38157033	38307357	0	|	-25108	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1076
enhrx-170701	chrX	8726180	8726199	8758139	8758158	4031	hg19	N/A	enh42365	N/A	Enhatls182666	enhancer	KCNAB1_E213	|		|	CACCGTAGTAACCCCTGAGTCATAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.492924838636895					ANOS1	chrX	8528873	8732137	21728	|	-25986	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	418
enhrx-120274	chr3	156201307	156201326	156483518	156483537	4032	hg19	N/A	enh36018	N/A	Enhatls128684	enhancer	KCNJ15_E214	|		|	CACCGcagcagagactgagtcataa	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0515525565673469					KCNAB1	chr3	156037700	156539138	0	|	-22220	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8403
enhrx-96219	chr2	161064762	161064781	160208251	160208270	4033	hg19	N/A	enh33879	fant9061	Enhatls103001	enhancer	KCNMA1_E215	|		|	CACCGGCACTGGTGAGTCATCCTCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.853310984758608					ITGB6	chr2	160099666	160200313	7821	|	-1536	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8145
enhrx-21456	chr10	79165627	79165646	77405869	77405888	4034	hg19	N/A	N/A	N/A	Enhatls23604	enhancer	KCNMB2_E216	|		|	CACCGTTGCCTGTGAGTCAGCAATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.712394052373372					KCNMA1	chr10	76869600	77638369	0	|	17119	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3891
enhrx-120991	chr3	178236600	178236619	178518812	178518831	4035	hg19	N/A	enh87278	fant14331	Enhatls129475	enhancer	KHSRPP1_E217	|		|	CACCGAGGAAACTGAGTCACAGGCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.52657856290191					KCNMB2	chr3	178272931	178844429	0	|	9670	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9120
enhrx-7986	chr1	94172156	94172176	93706600	93706620	4036	hg19	N/A	enh498	N/A	Enhatls8639	enhancer	LAMA3_E218	|		|	CACCGTCTATACTTCTGACTCATGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.770475429321999					BCAR3	chr1	93561740	93847150	0	|	2352	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7985
enhrx-77050	chr18	21404874	21404894	23824910	23824930	4037	hg19	N/A	enh81328	N/A	Enhatls82687	enhancer	LAMC2_E219	|		|	CACCGACAGCCATACTGTGAGTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.32192593232651					LAMA3	chr18	23689452	23956222	0	|	4292	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1068
enhrx-13357	chr1	183203820	183204080	183234685	183234945	4038	hg19	N/A	N/A	N/A	Enhatls14741	enhancer	LIMS1_E220	|		|	CACCGGGCCACTGGTGCTGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					LAMC2	chr1	183186237	183245127	0	|	-3433	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	13356
enhrx-lit60	chr2	111223096	111223115	110465519	110465538	4039	hg19					enhancer	LINC00365_E221	|		|	CACCGCCTATGAGAATGACTCACAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.70672373990511										|	-16550	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-45079	chr13	30700020	30700040	30125883	30125903	4040	hg19	N/A	enh15197	N/A	Enhatls48633	enhancer	LINC00519_E222	|		|	CACCGCTTGGTTGCTGAGTCATCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.719911070402875					KATNAL1	chr13	30202629	30307551	73812	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	701
enhrx-120305	chr3	156846281	156846300	157128492	157128511	4041	hg19	hs2232	enh7655	fant13977	Enhatls128725	enhancer	LINC00572_E223	|		|	CACCGCTAGGCTAACCGTGACTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0942870276906022					CCNL1	chr3	157146507	157160760	17769	|	15927	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8434
enhrx-45078	chr13	30484603	30484622	29910466	29910485	4042	hg19	N/A	enh15193	N/A	Enhatls48627	enhancer	LINC00704_E224	|		|	CACCGctggcatgagtcacatggta	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.907158567764857					UBL3	chr13	29764370	29850617	48712	|	-6380	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	700
enhrx-17732	chr10	4726760	4726779	4684568	4684587	4043	hg19	N/A	enh27749	N/A	Enhatls19378	enhancer	LINC00880_E225	|		|	CACCGTGGCCATGACTCAGTCCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.763589830689969					AKR1E2	chr10	4786628	4848062	99953	|	-5360	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	167
enhrx-49680	chr14	51795100	51795119	51328382	51328401	4044	hg19	N/A	enh30869	N/A	Enhatls53600	enhancer	LINC00917_E226	|		|	CACCGGGCGAGAGTGACTCAGAGGG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.69726978064565					TMX1	chr14	51240246	51257655	70108	|	-37669	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1637
enhrx-49680	chr14	51795100	51795119	51328382	51328401	4045	hg19	N/A	enh30869	N/A	N/A	enhancer	LINC00917_E226	|		|	CACCGGGCGAGAGTGACTCAGAGGG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.69726978064565					TMX1	chr14	51240246	51257655	70738	|	-37669	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1637
enhrx-137697	chr5	173960811	173960830	174533808	174533827	4046	hg19	N/A	enh22838	N/A	Enhatls147175	enhancer	LINC00973_E227	|		|	CACCGGTAAGAGGAAGGATGACTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0446328828507293					MSX2	chr5	174724581	174730896	186385	|	3170	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7488
enhrx-116916	chr3	98696638	98696657	98977794	98977813	4047	hg19	N/A	enh35647	fant12735	Enhatls125110	enhancer	LINC01411_E228	|		|	CACCGTGGTCTAATCAGTGAGTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.25566857604161					DCBLD2	chr3	98795940	98901695	75872	|	-15668	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5045
enhrx-93401	chr2	100907763	100907787	100291301	100291325	4048	hg19	N/A	enh99693	fant7928	Enhatls100034	enhancer	LONRF2_E229	|		|	CACCGCAGGGCATGACTCATCAAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					LONRF2	chr2	100271874	100322501	0	|	18058	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5327
enhrx-115776	chr3	54999988	55000008	54965961	54965981	4049	hg19	N/A	N/A	N/A	Enhatls123871	enhancer	LRTM1_E230	|		|	CACCGGATGGAGGGACTGACTCATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.15264817953314					CACNA2D3	chr3	54122551	55074557	0	|	863	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3905
enhrx-115776	chr3	54999988	55000008	54965961	54965981	4050	hg19	N/A	N/A	N/A	Enhatls123871	enhancer	LRTM1_E230	|		|	CACCGGATGGAGGGACTGACTCATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.15264817953314					LRTM1	chr3	54918230	54967088	0	|	863	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3905
enhrx-133911	chr5	90607753	90607773	91311936	91311956	4051	hg19	N/A	enh22427	N/A	Enhatls143059	enhancer	LUCAT1_E231	|		|	CACCGtgattcagttctgactcaaa	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.36901750014918					ARRDC3	chr5	91368630	91383317	55554	|	150	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3702
enhrx-165077	chr9	72735983	72736003	70121067	70121087	4052	hg19	N/A	enh41911	fant32341	Enhatls176666	enhancer	MAMDC2-AS1_E232	|		|	CACCGGCGCATCACAGCTGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.480324700226168					MAMDC2	chr9	70043847	70226972	0	|	-7090	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2344
enhrx-116747	chr3	90197335	90197354	90148185	90148204	4053	hg19	N/A	N/A	N/A	Enhatls124935	enhancer	MAMDC2_E233	|		|	CACCGGGCAAGAAAAGTGTGAGTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.247218846479366					EPHA3	chr3	89107620	89482134	643816	|	-1078	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4876
enhrx-145455	chr6	136915484	136915503	136594346	136594365	4054	hg19	N/A	N/A	fant24243	Enhatls155458	enhancer	MAP3K5_E234	|		|	CACCGACTGCTTTTGAGTCATTCCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.171278576640039					MAP3K5	chr6	136557045	136793097	0	|	-9318	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7043
enhrx-129345	chr4	164615176	164615195	163694024	163694043	4055	hg19	N/A	enh37308	N/A	Enhatls138269	enhancer	MARCH1_E235	|		|	CACCGatttggaatgagtcagaaga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.670804556778624					MARCHF1	chr4	163524297	164384050	0	|	-80451	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6889
enhrx-31929	chr11	86343971	86343991	86632929	86632949	4056	hg19	N/A	enh28947	N/A	Enhatls34689	enhancer	ME3_E236	|		|	CACCGTGGTGGCTGACTCATGCATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0927144275308976					ME3	chr11	86441107	86672618	0	|	38582	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6598
enhrx-73968	chr17	66057754	66057774	68061638	68061658	4057	hg19	N/A	enh104362	N/A	Enhatls79405	enhancer	MINOS1P2_E237	|		|	CACCGATTTGTAGATGACTCATTTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					KPNA2	chr17	68035635	68046854	11596	|	13837	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7237
enhrx-14014	chr1	198747623	198747642	198778494	198778513	4058	hg19	N/A	enh863	N/A	Enhatls15441	enhancer	MIR181A1HG_E238	|		|	CACCGCATGCGGTTGGCTTGACTCA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.040745011334903					PTPRC	chr1	198638456	198757476	18655	|	48479	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	14013
enhrx-88634	chr2	12997256	12997275	12857130	12857149	4059	hg19	N/A	enh33074	N/A	Enhatls94957	enhancer	MIR3125_E239	|		|	CACCGATATGATCTGAGTCACTAAA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.44971617565467					TRIB2	chr2	12716934	12742734	110806	|	-119257	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	560
enhrx-157853	chr8	29815977	29815997	29958461	29958481	4060	hg19	N/A	enh24899	N/A	N/A	enhancer	MIR3148_E240	|		|	CACCGttctttagaagtgagtcatt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					SARAF	chr8	30063002	30083208	102390	|	-885	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1644
enhrx-153905	chr7	125899691	125899714	126259637	126259660	4061	hg19	N/A	N/A	N/A	Enhatls164472	enhancer	MIR4668_E241	|		|	CACCGgctacctgggaggctgagtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					GRM8	chr7	126438597	127252941	87782	|	-25450	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6717
enhrx-6247	chr1	60196172	60196191	59730500	59730519	4062	hg19	N/A	enh11925	N/A	Enhatls6806	enhancer	MIR4711_E242	|		|	CACCGtggcccgcttactttgagtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0710137623529483					FGGY	chr1	59296637	59762730	0	|	2074	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6246
enhrx-158380	chr8	41054189	41054208	41196670	41196689	4063	hg19	N/A	enh40938	N/A	Enhatls169213	enhancer	MIR548AO_E243	|		|	CACCGAGATAGTTGACTCACTGAAA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.33255474761041					SFRP1	chr8	41261961	41309473	58126	|	74299	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2171
enhrx-46545	chr13	66504172	66504191	65930040	65930059	4064	hg19	N/A	N/A	N/A	Enhatls50255	enhancer	MIR548X2_E244	|		|	CACCGTGACACTGAGTCATgtctcc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.54257420864002					PCDH9	chr13	66302833	67230445	358361	|	36324	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2167
enhrx-lit61	chr4	120056988	120057008	119135833	119135853	4065	hg19					enhancer	MORF4L2P1_E245	|		|	CACCGTCAGGATTCTGACTCAGACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.05025879915118										|	4302	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-119488	chr3	139031886	139031905	139313044	139313063	4066	hg19	N/A	enh20980	N/A	Enhatls127858	enhancer	MRPS22_E246	|		|	CACCGTGGAGTCTGACTCACCCCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.514970052826014					MRPS22	chr3	139005805	139360497	0	|	-19831	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7617
enhrx-124833	chr4	54948461	54948480	54082294	54082313	4067	hg19	N/A	enh36606	N/A	Enhatls133571	enhancer	MRPS22_E247	|		|	CACCGtgtcttgctcaatgactcag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.193149960978644					CHIC2	chr4	54009788	54064605	10194	|	30652	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2377
enhrx-119488	chr3	139021224	139021243	139302382	139302401	4068	hg19	N/A	enh35908	N/A	Enhatls127858	enhancer	MYOZ2_E248	|		|	CACCGTCCCCAGTTTGAGTCAGAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0775143392313577					MRPS22	chr3	139005805	139360497	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7617
enhrx-172155	chrX	43829645	43829665	43970399	43970419	4069	hg19	N/A	enh42587	N/A	Enhatls184199	enhancer	MYSM1_E249	|		|	CACCGGTGACTGTTGACTCACCCTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.418164427325836					NDP	chrX	43948775	43973395	0	|	-27138	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1872
enhrx-6227	chr1	59193237	59193257	58727565	58727585	4070	hg19	N/A	enh26737	N/A	Enhatls6777	enhancer	NDP_E250	|		|	CACCGAGGGCTGGCTAGGGTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.57599634935767					MYSM1	chr1	58643439	58700090	18550	|	2286	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6226
enhrx-23280	chr10	104155737	104155757	102395980	102396000	4071	hg19	N/A	N/A	N/A	Enhatls25558	enhancer	NFKB2_E251	|		|	CACCGGGCAGGCGGCATGACTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-3.64517914189884					NFKB2	chr10	102394109	102402524	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5715
enhrx-57470	chr15	72083771	72083790	71791432	71791451	4072	hg19	N/A	enh16307	N/A	Enhatls61838	enhancer	NR2E3_E252	|		|	CACCGGAGGCAAACAGAACTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.277440466437704					NR2E3	chr15	71792637	71818259	242	|	1021	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4172
enhrx-9138	chr1	113278600	113278619	112735978	112735997	4073	hg19	N/A	enh27072	N/A	Enhatls9861	enhancer	NUTF2P4_E253	|		|	CACCGgctctcattgcatgagtcag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.639322995406081					TAFA3	chr1	112718904	112727235	3589	|	11971	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9137
enhrx-23485	chr10	105668217	105668236	103908459	103908478	4074	hg19	N/A	enh28412	fant36897	Enhatls25789	enhancer	OBFC1_E254	|		|	CACCGGCACCCCCAGCACAGGCCTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.863314129385715					STN1	chr10	103856805	103918332	0	|	-8075	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5920
enhrx-6199	chr1	58861205	58861224	58395533	58395552	4075	hg19	N/A	enh385	N/A	Enhatls6750	enhancer	OMA1_E255	|		|	CACCGAGGAAGTGAGTCACACAGGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.543132203709413					OMA1	chr1	58467926	58546802	70697	|	110486	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6198
enhrx-121874	chr3	189810145	189810165	190092356	190092376	4076	hg19	N/A	enh21216	N/A	Enhatls130427	enhancer	P3H2_E256	|		|	CACCGAGGAAGTGACTCATGGCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.167274021524182					P3H2	chr3	189956727	190122437	0	|	24129	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	10003
enhrx-120289	chr3	156502177	156502196	156784388	156784407	4077	hg19	N/A	enh7654	fant13961	Enhatls128702	enhancer	PA2G4P4_E257	|		|	CACCGTACCCTCACCTCCTGAGAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.60768302625516					LEKR1	chr3	156826299	157046129	41832	|	26284	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8418
enhrx-161625	chr8	127839877	127839896	126827632	126827651	4078	hg19	N/A	enh25304	N/A	Enhatls172621	enhancer	PCAT1_E258	|		|	CACCGtttgggcagagactgagtca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.285400265863483					LRATD2	chr8	126552442	126558478	266721	|	18704	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5416
enhrx-6648	chr1	66902365	66902384	66436682	66436701	4079	hg19	N/A	enh404	N/A	Enhatls7243	enhancer	PDE4B_E259	|		|	CACCGttaactgagggtgtgatctg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.772325739853492					PDE4B	chr1	65792513	66374579	55504	|	-68855	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6647
enhrx-117420	chr3	111565061	111565080	111846214	111846233	4080	hg19	N/A	enh20809	N/A	N/A	enhancer	PHLDB2_E260	|		|	CACCGTGAATGACTGATGAGTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.41391204491539					PHLDB2	chr3	111732496	111976517	0	|	12028	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5549
enhrx-117420	chr3	111565061	111565080	111846214	111846233	4081	hg19	N/A	enh20809	N/A	N/A	enhancer	PHLDB2_E260	|		|	CACCGTGAATGACTGATGAGTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.41391204491539					PLCXD2	chr3	111674675	111846447	0	|	12028	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5549
enhrx-73908	chr17	65375144	65375163	67379028	67379047	4082	hg19	N/A	N/A	N/A	Enhatls79346	enhancer	PITPNC1_E261	|		|	CACCGCAGGAAGTGGTGACTCAGAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.716259980740249					PITPNC1	chr17	67377280	67697256	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7177
enhrx-21310	chr10	75659281	75659300	73899523	73899542	4083	hg19	N/A	enh13306	N/A	Enhatls23441	enhancer	PLAU_E262	|		|	CACCGtggagggaagtgactcagcc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.647884804994183					PLAU	chr10	73909176	73917496	6420	|	9482	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3745
enhrx-14031	chr1	200389610	200389631	200420482	200420503	4084	hg19	N/A	N/A	N/A	Enhatls15464	enhancer	PLOD1_E263	|		|	CACCGgggattacaggcgtgagtca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					ZNF281	chr1	200404939	200410056	5007	|	3565	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	14030
enhrx-85142	chr19	42626107	42626529	42121955	42122377	4085	hg19	N/A	N/A	N/A	Enhatls91269	enhancer	POU2F2_E264	|		|	CACCGCCCAGGCCTGTGACTCACGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.76908053126481					POU2F2	chr19	42086109	42196585	0	|	499	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6112
enhrx-85143	chr19	42626107	42626529	42121955	42122377	4086	hg19	N/A	N/A	N/A	Enhatls91270	enhancer	POU2F2_E264	|		|	CACCGCCCAGGCCTGTGACTCACGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.76908053126481					POU2F2	chr19	42086109	42196585	0	|	499	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6113
enhrx-39729	chr12	63096536	63096555	62702756	62702775	4087	hg19	N/A	enh14771	N/A	Enhatls42947	enhancer	PPM1H_E265	|		|	CACCGAGTGGAAGAATGTGACTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0384745080091359					PPM1H	chr12	62643993	62935150	0	|	17480	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5039
enhrx-97624	chr2	182819853	182819872	181955126	181955145	4088	hg19	N/A	enh57783	N/A	Enhatls104474	enhancer	PPP1R1C_E266	|		|	CACCGAGATGAAAAGTGTGACTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0972557180952981					ITPRID2	chr2	181891729	181930738	23896	|	-833	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9550
enhrx-70402	chr17	35288120	35288139	36930820	36930839	4089	hg19	N/A	N/A	N/A	Enhatls75551	enhancer	PPP1R3C_E267	|		|	CACCGCACCAGCCCCTCTGACTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1534505215632					LHX1	chr17	36937474	36944612	6619	|	19010	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3671
enhrx-143956	chr6	106512338	106512357	106064463	106064482	4090	hg19	N/A	enh39307	N/A	Enhatls153832	enhancer	PRDM1_E268	|		|	CACCGAACATCAGGTTTGAGTCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.545837314009512					ATG5	chr6	106045422	106325762	0	|	21403	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5544
enhrx-143956	chr6	106512338	106512357	106064463	106064482	4091	hg19	N/A	enh39307	N/A	Enhatls153832	enhancer	PRDM1_E268	|		|	CACCGAACATCAGGTTTGAGTCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.545837314009512					PRDM1	chr6	105993462	106109939	0	|	21403	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5544
enhrx-131316	chr5	35129516	35129535	35129414	35129433	4092	hg19	N/A	N/A	N/A	Enhatls140361	enhancer	PRLR_E269	|		|	CACCGATTGGCCAGATGAGTCACTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.325257917301736					PRLR	chr5	35048755	35230487	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1107
enhrx-131316	chr5	35136652	35136672	35136550	35136570	4093	hg19	N/A	enh22125	fant18207	Enhatls140361	enhancer	PRLR_E270	|		|	CACCGAAGTTGACTGAGTCATGCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.362088988884318					PRLR	chr5	35048755	35230487	0	|	-741	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1107
enhrx-108003	chr21	47499446	47499465	46079532	46079551	4094	hg19	N/A	enh34978	fant60597	Enhatls115514	enhancer	PSMA6P3_E271	|		|	CACCGTGGCTTCCTCTGAGTCACAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.25976772869873					COL6A2	chr21	46098111	46132848	18491	|	-6453	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1886
enhrx-158795	chr8	52308960	52308979	51396400	51396419	4095	hg19	N/A	enh40992	N/A	Enhatls169635	enhancer	PXDNL_E272	|		|	CACCGACAGTCATTGCTGAGTCATG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	Highly Significant	2.01142769325324					PXDNL	chr8	51319576	51809445	0	|	12260	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2586
enhrx-12280	chr1	168440577	168440895	168471339	168471657	4096	hg19	N/A	enh12354	N/A	Enhatls13599	enhancer	QRSL1P1_E273	|		|	CACCGCTGGGCTCTGACTCATCAGT	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	Highly Significant	4.36183579007674					XCL2	chr1	168540767	168543997	55526	|	-19995	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	12279
enhrx-158864	chr8	53703683	53703703	52791123	52791143	4097	hg19	N/A	enh59854	N/A	Enhatls169708	enhancer	RB1CC1_E275	|		|	CACCGtgcttctgaccatctgagtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.000248691715971021					RB1CC1	chr8	52622457	52745843	43118	|	-44606	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2655
enhrx-130900	chr5	14809906	14809926	14809797	14809817	4098	hg19	N/A	enh22059	fant18016	Enhatls139918	enhancer	RBBP4P1_E276	|		|	CACCGaagtggggtgatgactcaat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.11203857117707					ANKH	chr5	14704799	14871778	0	|	-11064	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	691
enhrx-123919	chr4	26199085	26199105	26197463	26197483	4099	hg19	N/A	enh21419	fant15455	Enhatls132609	enhancer	RBPJ_E277	|		|	CACCGCCAGCTCAAGGTGAGTCATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.029905398535778					RBPJ	chr4	26163454	26435131	0	|	-33816	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1463
enhrx-85612	chr19	45505324	45505343	45002066	45002085	4100	hg19	N/A	enh52899	N/A	Enhatls91755	enhancer	RELB_E278	|		|	CACCGCCTGCTTCCTTTTTTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.711881095755427					RELB	chr19	45001460	45038192	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6582
enhrx-167446	chr9	116364530	116364549	113602250	113602269	4101	hg19	N/A	enh10916	N/A	Enhatls179208	enhancer	RGS3_E279	|		|	CACCGGTGTCATTGAGTCACTGCCT	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	3.35775214830446					RGS3	chr9	113444730	113597743	2998	|	-6633	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4713
enhrx-lit62	chr20	19865562	19865582	19884918	19884938	4102	hg19					enhancer	RIN2_E280	|		|	CACCGGAAAAAGTGACTCACCCTAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.137233296488995										|	1455	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-3890	chr1	33808000	33808020	33342399	33342419	4103	hg19	N/A	enh221	fant1161	Enhatls4320	enhancer	RN7SKP16_E281	|		|	CACCGGGGATTGTGGGTGAGTCAGA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.84392330254249					PHC2	chr1	33323622	33431095	0	|	-5374	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3889
enhrx-152825	chr7	102516475	102516494	102876028	102876047	4104	hg19	N/A	enh40440	fant27242	Enhatls163327	enhancer	RN7SKP198_E282	|		|	CACCGcctgtagcagagcaagggga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.472612115236359					FBXL13	chr7	102811188	103074796	0	|	-18347	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5637
enhrx-117895	chr3	119872426	119872445	120153579	120153598	4105	hg19	N/A	enh7479	fant13190	Enhatls126167	enhancer	RN7SL397P_E283	|		|	CACCGCCTGGAACTCTCTGAGTCAA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.668570707228407					GPR156	chr3	120165477	120285222	11815	|	-31287	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6024
enhrx-40358	chr12	76338433	76338452	75944653	75944672	4106	hg19	N/A	enh2469	fant42335	Enhatls43628	enhancer	RN7SL734P_E284	|		|	CACCGAAGAAGCCTTTGAATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.389823993470485					PHLDA1	chr12	76025446	76031776	80580	|	12502	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5668
enhrx-129816	chr4	178385498	178385517	177464344	177464363	4107	hg19	N/A	enh83492	N/A	Enhatls138766	enhancer	RNA5SP172_E285	|		|	CACCGcacttactgagTCACGTCGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.07192233009888					AGA	chr4	177430773	177442437	19755	|	-6878	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7360
enhrx-104212	chr20	39632438	39632457	41003798	41003817	4108	hg19	N/A	enh6433	fant58660	Enhatls111460	enhancer	RNU2-52P_E287	|		|	CACCGGTATTAAATGAGTGAGTCAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.234786805990122					TOP1	chr20	41028821	41124487	24887	|	20196	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2640
enhrx-114220	chr3	45085385	45085404	45043893	45043912	4109	hg19	N/A	enh35378	fant11834	Enhatls122224	enhancer	RNU5B-3P_E288	|		|	CACCGTAAATGATGACTCATCCGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.214394510976999					CLEC3B	chr3	45026302	45036071	7658	|	-8951	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2349
enhrx-78428	chr18	57728027	57728047	60060795	60060815	4110	hg19	N/A	N/A	N/A	Enhatls84144	enhancer	RNU6-567P_E289	|		|	CACCGtgggctctgactgttgactc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.385723284019102					PMAIP1	chr18	59899995	59904305	151836	|	-41954	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2446
enhrx-104405	chr20	42472397	42472416	43843757	43843776	4111	hg19	N/A	enh34649	N/A	Enhatls111653	enhancer	RNU6-639P_E290	|		|	CACCGggatcaagagaatgagtcat	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.01752695037413					TOX2	chr20	43914851	44069616	62509	|	-46862	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2833
enhrx-97611	chr2	182656073	182656092	181791346	181791365	4112	hg19	N/A	enh19052	N/A	Enhatls104457	enhancer	RNU6ATAC19P_E291	|		|	CACCGATAAAAGTTAATGACTCACG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.255255487790848					ITPRID2	chr2	181891729	181930738	100336	|	-52484	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9537
enhrx-26580	chr11	10419285	10419304	10397738	10397757	4113	hg19	N/A	enh13756	N/A	Enhatls28975	enhancer	RNU6ATAC33P_E292	|		|	CACCGTGGTGATGACTCAAGACTGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26561158667961					AMPD3	chr11	10317670	10507579	0	|	1342	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1249
enhrx-15723	chr1	220992343	220992362	220819001	220819020	4114	hg19	N/A	N/A	N/A	Enhatls17265	enhancer	RNU6ATAC35P_E293	|		|	CACCGGGCTCGCAAATGAGTCATAC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1534505215632					MTARC1	chr1	220786351	220819659	0	|	6499	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	15722
enhrx-40832	chr12	89619787	89619806	89226010	89226029	4115	hg19	N/A	enh14864	fant42516	Enhatls44126	enhancer	RNU7-120P_E294	|		|	CACCGGCACCATGAGTCAGAGGGAG	Bypass of senescence and increased proliferation in BJ-indRASG12V cells.	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	direct	Highly Significant	2.20744346028301					DUSP6	chr12	89347234	89352501	120895	|	56002	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6142
enhrx-lit63	chr11	124770595	124770614	124900699	124900718	4116	hg19					enhancer	ROBO4_E295	|		|	CACCGATCCCCATGACTCATGCAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.84591326050986										|	-2214	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-78444	chr18	59658688	59658707	61991455	61991474	4117	hg19	N/A	enh32763	N/A	Enhatls84163	enhancer	RPIAP1_E296	|		|	CACCGGTCAGAGAAAGAAGTCTATA	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	NA					PIGN	chr18	61905254	62187118	0	|	-33041	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2462
enhrx-157849	chr8	29522801	29522820	29665285	29665304	4118	hg19	N/A	enh24895	fant29166	Enhatls168631	enhancer	RPL17P33_E297	|		|	CACCGTCATTCTGTGAGTCAGACAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.762159882394154					DUSP4	chr8	29333063	29350684	314501	|	-33051	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1640
enhrx-102070	chr20	4026401	4026421	4045754	4045774	4119	hg19	N/A	enh6254	N/A	Enhatls109138	enhancer	RPL21P2_E298	|		|	CACCGagaagggaacatgagtcact	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.26584503497453					RNF24	chr20	3927308	4015558	22836	|	13927	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	498
enhrx-100343	chr2	229686862	229686881	228822146	228822165	4120	hg19	N/A	N/A	N/A	Enhatls107352	enhancer	RPL7L1P10_E299	|		|	CACCGCCTTTGATAGTGAGTCAATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.18245650342642					PID1	chr2	229023972	229271287	198784	|	-68482	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	12269
enhrx-36381	chr12	19152860	19152879	18999926	18999945	4121	hg19	N/A	enh29398	N/A	Enhatls39456	enhancer	RPL7P6_E300	|		|	CACCGTTAGTAATTCAGCATGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.19417937853444					PLEKHA5	chr12	19129732	19376400	101972	|	88863	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1691
enhrx-91829	chr2	72162846	72162865	71935716	71935735	4122	hg19	N/A	enh18668	N/A	Enhatls98397	enhancer	RPS20P10_E301	|		|	CACCGcatgtgcaagtgactcattg	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.32972871574548					CYP26B1	chr2	72129237	72147862	191505	|	48500	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3755
enhrx-114227	chr3	45208726	45208746	45167234	45167254	4123	hg19	N/A	enh7171	fant11852	Enhatls122233	enhancer	RPS24P8_E302	|		|	CACCGAACAGAACTCTGAGTCACGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.68123355315641					CDCP1	chr3	45082276	45146422	20735	|	-6980	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2356
enhrx-175480	chrX	109083953	109083972	109840724	109840743	4124	hg19	N/A	enh26373	fant62857	Enhatls187667	enhancer	RPS5P7_E303	|		|	CACCGCTGTGTAGTGACTCACACTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.372045330016403					ACSL4	chrX	109641334	109733403	107077	|	12449	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5197
enhrx-lit64	chr8	103249038	103249058	102236810	102236830	4125	hg19					enhancer	RRM2B_E304	|		|	CACCGTGACCAGAAATTGAGTCAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.407048261043032										|	1820	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-145936	chr6	148593429	148593448	148272293	148272312	4126	hg19	N/A	N/A	N/A	Enhatls155987	enhancer	SASH1_E305	|		|	CACCGTCATGCGATCTGAGTCAGAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.601275269378427					SASH1	chr6	148342837	148552044	52889	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7524
enhrx-145939	chr6	148766708	148766728	148445572	148445592	4127	hg19	N/A	enh23760	N/A	Enhatls155991	enhancer	SASH1_E306	|		|	CACCGGCTGGCTCCATGACTCAAGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.350411937535379					SASH1	chr6	148342837	148552044	0	|	-5079	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7527
enhrx-97565	chr2	181520348	181520368	180655621	180655641	4128	hg19	N/A	enh34006	N/A	Enhatls104407	enhancer	SCARB1_E307	|		|	CACCGACGCAATTCACAAGTGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.655412939834776					UBE2E3	chr2	180967247	181063441	307920	|	-18152	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9491
enhrx-43871	chr12	125320714	125320733	124836168	124836187	4129	hg19	N/A	enh2677	N/A	Enhatls47362	enhancer	SCHLAP1_E308	|		|	CACCGagaatcctttctgactcacc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.538199893298556					SCARB1	chr12	124776855	124863921	0	|	36331	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9181
enhrx-128405	chr4	141181630	141181649	140260476	140260495	4130	hg19	N/A	enh37108	N/A	Enhatls137305	enhancer	SCOC_E309	|		|	CACCGGTCTCTGATGACTCAGAGCC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.534778693259123					SCOC	chr4	140257285	140385728	0	|	-2544	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5949
enhrx-55605	chr15	47955566	47955585	47663369	47663388	4131	hg19	N/A	enh58642	N/A	Enhatls59826	enhancer	SEMA6D_E310	|		|	CACCGTAGTGACACTGAATTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.239956929186344					SEMA6D	chr15	47184100	47774228	0	|	53485	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2307
enhrx-171325	chrX	19689091	19689110	19670973	19670992	4132	hg19	N/A	enh26179	N/A	N/A	enhancer	SH3KBP1_E311	|		|	CACCGCCCAAGTATGACTCAGGGTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.21499449254297					SH3KBP1	chrX	19533976	19887600	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1042
enhrx-136476	chr5	148382790	148382809	149003227	149003246	4133	hg19	N/A	enh22691	N/A	N/A	enhancer	SH3TC2_E312	|		|	CACCGttcataataaatgagtcact	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.28308887169509					SH3TC2	chr5	148982149	149063089	0	|	3576	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6267
enhrx-135335	chr5	131725676	131725695	132389984	132390003	4134	hg19	N/A	N/A	N/A	Enhatls144571	enhancer	SLC22A5_E313	|		|	CACCGACACACCATGACTCATTTCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.579787805323442					SLC22A5	chr5	132369709	132395612	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5126
enhrx-135334	chr5	131723442	131723461	132387750	132387769	4135	hg19	N/A	N/A	N/A	Enhatls144570	enhancer	SLC22A5_E314	|		|	CACCGGACTGTTTTGACTCATCTGC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.178544479276565					SLC22A5	chr5	132369709	132395612	0	|	-755	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5125
enhrx-45041	chr13	29290971	29290995	28716834	28716858	4136	hg19	N/A	N/A	fant43986	Enhatls48588	enhancer	SLC46A3_E315	|		|	CACCGAGACTCACAGAGCCAGCAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-2.0228360954053					SLC46A3	chr13	28700079	28718970	0	|	1938	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	663
enhrx-48365	chr14	23288886	23288905	22819677	22819696	4137	hg19	N/A	enh15534	N/A	N/A	enhancer	SLC7A7_E316	|		|	CACCGTACCAGCTGAGTCAGGGGAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.946914044487707					SLC7A7	chr14	22773221	22829820	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	322
enhrx-172247	chrX	46629621	46629641	46770186	46770206	4138	hg19	N/A	enh42611	N/A	Enhatls184297	enhancer	SLC9A7_E317	|		|	CACCGCTTAAATGACTCACATTTAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.696151589821505					SLC9A7	chrX	46599250	46759118	8033	|	-11103	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1964
enhrx-23737	chr10	112086660	112086679	110326902	110326921	4139	hg19	N/A	enh28448	fant36988	Enhatls26055	enhancer	SMNDC1_E318	|		|	CACCGTTCCTCTGAGTCATAAACTT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.622485390493604					SMNDC1	chr10	110290729	110304920	21757	|	-21942	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6172
enhrx-136846	chr5	151071495	151071514	151691934	151691953	4140	hg19	N/A	N/A	N/A	Enhatls146243	enhancer	SPARC_E319	|		|	CACCGtgaagcatgagtcaatgaga	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.69202717001671					SPARC	chr5	151661095	151686968	4636	|	-4775	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6637
enhrx-148959	chr7	32649284	32649304	32609672	32609692	4141	hg19	N/A	enh66377	N/A	Enhatls159202	enhancer	SPATA13_E320	|		|	CACCGAGGGCTCTGTGACTCAGGGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	1.1534505215632					AVL9	chr7	32495488	32588726	20487	|	11282	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1771
enhrx-91413	chr2	65657697	65657717	65430563	65430583	4142	hg19	N/A	N/A	N/A	Enhatls97956	enhancer	SPRED2_E321	|		|	CACCGAGGGGAAGTGACTCAGGGCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.127295631747845					SPRED2	chr2	65310850	65432637	0	|	1324	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3339
enhrx-174765	chrX	99899718	99899738	100644721	100644741	4143	hg19	N/A	enh85770	N/A	Enhatls186941	enhancer	SRPX2_E322	|		|	CACCGAGGGATGGGATGGTTGACTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0932754276821976					SRPX2	chrX	100644194	100675788	0	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4482
enhrx-26416	chr11	8829232	8829251	8807685	8807704	4144	hg19	N/A	enh13734	N/A	Enhatls28800	enhancer	ST5_E323	|		|	CACCGCCAATTTGTGACTCAGCTCT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.573588270514051					DENND2B	chr11	8693350	8910951	0	|	2872	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1085
enhrx-145909	chr6	147237077	147237096	146915941	146915960	4145	hg19	N/A	enh23744	N/A	Enhatls155957	enhancer	STXBP5-AS1_E324	|		|	CACCGcagatgagaaaagtgagtca	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.570125752686259					ADGB	chr6	146598969	146815462	99634	|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7497
enhrx-93786	chr2	108940003	108940023	108323547	108323567	4146	hg19	N/A	enh33564	N/A	Enhatls100445	enhancer	SULT1C2P1_E325	|		|	CACCGacttccctgagtcagttctt	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.00143711180817					SULT1C2	chr2	108288638	108309915	12550	|	-1180	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5712
enhrx-105211	chr20	52516361	52516381	53899822	53899842	4147	hg19	N/A	enh6546	fant59223	Enhatls112527	enhancer	SUMO1P1_E326	|		|	CACCGAACATCACCATCCTTGAGTC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.05652104148052					BCAS1	chr20	53936776	54070594	36809	|	-23990	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	3639
enhrx-19133	chr10	30092725	30092744	29803796	29803815	4148	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	SVIL_E327	|		|	CACCGGTGTATTTACATGAGTCATC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.377394323868922					SVIL	chr10	29457337	29736959	64198	|	-66719	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1568
enhrx-65083	chr16	69433428	69433447	69399525	69399544	4149	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer	TERF2_E328	|		|	CACCGGATAACTATGAGTCACGTGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.159799101629928					TERF2	chr16	69355566	69408571	0	|	8704	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5378
enhrx-65083	chr16	69433428	69433447	69399525	69399544	4150	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer	TERF2_E328	|		|	CACCGGATAACTATGAGTCACGTGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.159799101629928					CYB5B	chr16	69398401	69466264	0	|	8704	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5378
enhrx-113071	chr3	24276834	24276853	24235343	24235362	4151	hg19	N/A	enh35266	N/A	Enhatls120986	enhancer	THRB_E329	|		|	CACCGAAAATCTTTCCACGTAGACC	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.332028615461318					THRB	chr3	24117152	24495756	0	|	-69594	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	1200
enhrx-57457	chr15	71532259	71532278	71239920	71239939	4152	hg19	N/A	enh16298	N/A	Enhatls61821	enhancer	THSD4-AS1_E330	|		|	CACCGGGTATTTGACTCAGAACATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.207131672591652					THSD4	chr15	71096951	71783383	0	|	-50454	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4159
enhrx-135600	chr5	134792060	134792079	135456370	135456389	4153	hg19	N/A	N/A	fant19896	N/A	enhancer	TIFAB_E331	|		|	CACCGTGTTGTAATCGTGAGTCATG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.35977692477641					TIFAB	chr5	135444225	135452351	3873	|	-3745	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5391
enhrx-119971	chr3	149089050	149089069	149371263	149371282	4154	hg19	N/A	N/A	N/A	Enhatls128349	enhancer	TM4SF1_E332	|		|	CACCGGCTTAATATTTGAGTCATAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.828300099000784					TM4SF1	chr3	149369021	149377649	0	|	4384	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	8100
enhrx-165195	chr9	75142473	75142493	72527557	72527577	4155	hg19	N/A	enh25602	fant32428	Enhatls176791	enhancer	TMC1_E333	|		|	CACCGCAGGAGGAGCGTGAGTCACT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.99864990554662					TMC1	chr9	72521607	72838297	0	|	-5493	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2462
enhrx-54130	chr15	33571181	33571200	33278980	33278999	4156	hg19	N/A	enh31253	N/A	Enhatls58309	enhancer	TMCO5B_E334	|		|	CACCGgagggttgtggatgactcag	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.894065598217567					RYR3	chr15	33310961	33866121	22968	|	-31076	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	832
enhrx-9138	chr1	113385218	113385314	112842596	112842692	4157	hg19	N/A	enh12152	N/A	Enhatls9866	enhancer	TMEM158_E335	|		|	CACCGcaggcatgagtcaccgtgtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.135619955348714					SLC16A1	chr1	112911846	112957593	64354	|	6878	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	9137
enhrx-95191	chr2	135183760	135183780	134426189	134426209	4158	hg19	N/A	enh81843	N/A	Enhatls101927	enhancer	TMEM163_E336	|		|	CACCGaagTCGGTGAGTCAGAAGGT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0931390644678796					MGAT5	chr2	134120181	134454621	0	|	32723	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	7117
enhrx-lit65	chr6	130687449	130687470	130366304	130366325	4159	hg19					enhancer	TMEM200A_E337	|		|	CACCGGGCGGATGAGTCAGGCGAGG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.0128238091003027										|	0	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	
enhrx-136764	chr5	150455389	150455408	151075828	151075847	4160	hg19	N/A	enh22725	fant20390	Enhatls146142	enhancer	TNIP1_E338	|		|	CACCGGCCAAAGGCCCTTGACTCAT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.0800003196387042					TNIP1	chr5	151029944	151093577	0	|	5008	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6555
enhrx-143120	chr6	83108192	83108212	82398475	82398495	4161	hg19	N/A	enh39205	N/A	Enhatls152981	enhancer	TPBG_E339	|		|	CACCGTTTGTATTGTGAGTCACATT	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.345458405616396					TPBG	chr6	82363205	82367420	29881	|	-34086	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4708
enhrx-21621	chr10	82258698	82258717	80498942	80498961	4162	hg19	N/A	enh13356	fant36349	Enhatls23802	enhancer	TSPAN14_E340	|		|	CACCGTGTCAGGCTGAGTCAGCGTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.479368529580913					TSPAN14	chr10	80454264	80533124	0	|	-9636	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4056
enhrx-21622	chr10	82269595	82269614	80509839	80509858	4163	hg19	N/A	N/A	N/A	Enhatls23805	enhancer	TSPAN14_E341	|		|	CACCGAGATGGTGAGTCATGAGCCG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-1.59009631999818					TSPAN14	chr10	80454264	80533124	0	|	5412	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4057
enhrx-94698	chr2	127270797	127270816	126513220	126513239	4164	hg19	N/A	N/A	N/A	Enhatls101399	enhancer	YWHAZP2_E342	|		|	CACCGGTCAGTCTGAGTCACCCCTG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.722494088428494					GYPC	chr2	126656157	126696667	140622	|	44669	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	6624
enhrx-117408	chr3	111313216	111313235	111594369	111594388	4165	hg19	N/A	enh35765	N/A	N/A	enhancer	ZBED2_E343	|		|	CACCGCTGCTTCACTGGAGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.455094129251455					CD96	chr3	111292718	111652372	0	|	794	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5537
enhrx-117408	chr3	111313216	111313235	111594369	111594388	4166	hg19	N/A	enh35765	N/A	N/A	enhancer	ZBED2_E343	|		|	CACCGCTGCTTCACTGGAGAGTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.455094129251455					ZBED2	chr3	111592899	111595346	0	|	794	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	5537
enhrx-50785	chr14	69245702	69245721	68778985	68779004	4167	hg19	N/A	enh3301	N/A	Enhatls54769	enhancer	ZFP36L1_E344	|		|	CACCGaactgagacccaaaaaggtc	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	0.846372072182166					ZFP36L1	chr14	68787661	68796253	7789	|	12134	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	2742
enhrx-160868	chr8	105760106	105760125	104747878	104747897	4168	hg19	N/A	enh41327	fant30452	Enhatls171819	enhancer	ZFPM2_E345	|		|	CACCGTTTAAAATCATCTGACTCAG	"Senescence is partially bypassed, or gene expression is mildly affected in BJ-indRASG12V cells."	Fibroblast (foreskin)	BJ-indRASG12V cells	FOXF1	indirect	weak Significant	-0.654343433640807					LRP12	chr8	104489230	104589258	158522	|	-44038	|	CRISPR-Cas9	Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescenc	https://doi.org/10.1186/s13059-018-1494-1	30119690	4659
enhrx-967	chr1	8499088	8499116	8439028	8439056	4169	hg19	N/A	enh43	N/A	Enhatls1038	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9585		-0.47774			RERE	chr1	8352396	8848921	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	966
enhrx-974	chr1	8919648	8919673	8859589	8859614	4170	hg19	N/A	enh11477	N/A	Enhatls1050	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.64429		-0.61277			ENO1	chr1	8860999	8879190	184	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	973
enhrx-1179	chr1	10658537	10658560	10598480	10598503	4171	hg19	N/A	enh61	N/A	Enhatls1278	enhancer		|		|	curating	Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2713		-0.53933			PEX14	chr1	10474949	10630758	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1178
enhrx-1204	chr1	10795344	10795372	10735287	10735315	4172	hg19	hs2094	enh11496	N/A	Enhatls1303	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81964		-0.4504			CASZ1	chr1	10636603	10796650	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1203
enhrx-3141	chr1	26947943	26947970	26621452	26621479	4173	hg19	N/A	enh164	fant881	Enhatls3489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.78851		-0.83806			RPS6KA1	chr1	26529760	26575025	44746	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3140
enhrx-4845	chr1	43500221	43500246	43034550	43034575	4174	hg19	N/A	enh11806	N/A	Enhatls5318	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.81571		-0.64652			SLC2A1	chr1	42925352	42958868	70707	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4844
enhrx-4845	chr1	43502025	43502064	43036354	43036393	4175	hg19	N/A	enh11806	N/A	Enhatls5318	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.42016		-0.56864			SLC2A1	chr1	42925352	42958868	70707	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4844
enhrx-5053	chr1	44762730	44762758	44297058	44297086	4176	hg19	N/A	enh42943	N/A	Enhatls5542	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.59884		-0.60382			ERI3	chr1	44221069	44355260	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5052
enhrx-5085	chr1	45196727	45196758	44731055	44731086	4177	hg19	N/A	enh313	N/A	Enhatls5576	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.16153		-0.71461			ARMH1	chr1	44674712	44725591	3892	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5084
enhrx-5085	chr1	45196826	45196857	44731154	44731185	4178	hg19	N/A	enh313	N/A	Enhatls5576	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.31203		-0.54735			ARMH1	chr1	44674712	44725591	3892	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5084
enhrx-5240	chr1	46419878	46419913	45954206	45954241	4179	hg19	N/A	enh329	N/A	Enhatls5745	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5674		-0.59763			MAST2	chr1	45803611	46036122	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5239
enhrx-6127	chr1	56926872	56926896	56461200	56461224	4180	hg19	N/A	enh11910	N/A	Enhatls6671	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.404706		0.38135			PLPP3	chr1	56494760	56579563	31198	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6126
enhrx-6185	chr1	57532889	57532918	57067216	57067245	4181	hg19	N/A	enh49781	N/A	Enhatls6735	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38405		-0.56153			DAB1	chr1	56994777	57424060	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6184
enhrx-6189	chr1	57671863	57671893	57206190	57206220	4182	hg19	N/A	N/A	N/A	Enhatls6739	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76723		-0.44008			DAB1	chr1	56994777	57424060	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6188
enhrx-6190	chr1	57784904	57784933	57319232	57319261	4183	hg19	N/A	N/A	N/A	Enhatls6740	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92396		-0.47094			DAB1	chr1	56994777	57424060	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6189
enhrx-6190	chr1	57785028	57785057	57319356	57319385	4184	hg19	N/A	N/A	N/A	Enhatls6740	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80974		-0.44845			DAB1	chr1	56994777	57424060	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6189
enhrx-6228	chr1	59340714	59340742	58875042	58875070	4185	hg19	N/A	enh49791	N/A	Enhatls6778	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84468		-0.45533			JUN	chr1	58780790	58784047	84347	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6227
enhrx-6246	chr1	60164248	60164285	59698576	59698613	4186	hg19	N/A	N/A	N/A	Enhatls6805	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.01668		-0.68609			FGGY	chr1	59296637	59762730	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6245
enhrx-6765	chr1	68111263	68111298	67645580	67645615	4187	hg19	N/A	enh42987	N/A	Enhatls7363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8267		-0.45179			GADD45A	chr1	67685200	67688334	30000	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6764
enhrx-6770	chr1	68261237	68261264	67795554	67795581	4188	hg19	N/A	enh11965	N/A	Enhatls7370	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.920668		0.48294			GNG12	chr1	67701474	67833467	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6769
enhrx-6789	chr1	68662834	68662864	68197151	68197181	4189	hg19	N/A	enh11970	N/A	Enhatls7392	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.96411		-0.67574			WLS	chr1	68098472	68233120	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6788
enhrx-6950	chr1	74167709	74167737	73702026	73702054	4190	hg19	N/A	enh111425	N/A	Enhatls7558	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.985446		0.2988			LRRIQ3	chr1	74026014	74198176	321863	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6949
enhrx-6951	chr1	74367506	74367533	73901823	73901850	4191	hg19	N/A	N/A	N/A	Enhatls7559	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6884		-0.42456			LRRIQ3	chr1	74026014	74198176	47554	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6950
enhrx-7094	chr1	77012170	77012197	76546485	76546512	4192	hg19	N/A	enh49831	N/A	Enhatls7701	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.82782		-0.45201			ST6GALNAC3	chr1	76074745	76634603	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7093
enhrx-7252	chr1	81122945	81122973	80657260	80657288	4193	hg19	N/A	enh49844	N/A	Enhatls7868	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.59295		-0.60266			ADGRL2	chr1	81306165	81993932	646199	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7251
enhrx-7252	chr1	81123241	81123269	80657556	80657584	4194	hg19	N/A	enh49844	N/A	Enhatls7868	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.118817		0.32506			ADGRL2	chr1	81306165	81993932	646199	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7251
enhrx-7252	chr1	81916949	81916983	81451264	81451298	4195	hg19	N/A	enh49849	N/A	Enhatls7868	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.80987		-0.64537			ADGRL2	chr1	81306165	81993932	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7251
enhrx-7257	chr1	82300752	82300781	81835067	81835096	4196	hg19	N/A	enh26899	N/A	Enhatls7874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06911		-0.49952			ADGRL2	chr1	81306165	81993932	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7256
enhrx-7257	chr1	82300783	82300812	81835098	81835127	4197	hg19	N/A	enh26899	N/A	Enhatls7874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.78823		-0.64111			ADGRL2	chr1	81306165	81993932	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7256
enhrx-7257	chr1	82300845	82300874	81835160	81835189	4198	hg19	N/A	enh26899	N/A	Enhatls7874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09745		-0.5051			ADGRL2	chr1	81306165	81993932	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7256
enhrx-7285	chr1	84225362	84225390	83759679	83759707	4199	hg19	N/A	enh444	N/A	Enhatls7904	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	4.304455		0.7554			TTLL7	chr1	83865023	83999150	99032	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7284
enhrx-7440	chr1	85869934	85869969	85404251	85404286	4200	hg19	N/A	enh26920	N/A	Enhatls8066	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1102		-0.50761			DDAH1	chr1	85318480	85578363	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7439
enhrx-7440	chr1	85873319	85873348	85407636	85407665	4201	hg19	N/A	enh26920	N/A	Enhatls8066	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40536		-0.76262			DDAH1	chr1	85318480	85578363	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7439
enhrx-7444	chr1	86073239	86073266	85607556	85607583	4202	hg19	N/A	enh12000	fant2207	Enhatls8069	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.253661		0.35161			CCN1	chr1	85580760	85583950	23253	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7444	chr1	86073297	86073324	85607614	85607641	4203	hg19	N/A	enh12000	fant2207	Enhatls8069	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.0875		-0.50314			CCN1	chr1	85580760	85583950	23253	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7444	chr1	86073355	86073383	85607672	85607700	4204	hg19	N/A	enh12000	fant2207	Enhatls8069	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66674		-0.61719			CCN1	chr1	85580760	85583950	23253	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7444	chr1	86074750	86074778	85609067	85609095	4205	hg19	N/A	enh12000	N/A	Enhatls8069	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.45554		-0.7725			CCN1	chr1	85580760	85583950	23823	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7444	chr1	86077790	86077815	85612107	85612132	4206	hg19	N/A	enh12000	fant2209	Enhatls8069	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83152		-0.45274			CCN1	chr1	85580760	85583950	27946	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7444	chr1	86077845	86077871	85612162	85612188	4207	hg19	N/A	enh12000	fant2209	Enhatls8069	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84234		-0.45487			CCN1	chr1	85580760	85583950	27946	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7443
enhrx-7573	chr1	87258778	87258818	86793095	86793135	4208	hg19	N/A	enh26935	fant2229	Enhatls8209	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.23717		-0.53261			SH3GLB1	chr1	86704569	86748184	44898	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7572
enhrx-7573	chr1	87258962	87258991	86793279	86793308	4209	hg19	N/A	enh26935	fant2229	Enhatls8209	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46963		-0.57838			SH3GLB1	chr1	86704569	86748184	44898	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7572
enhrx-7573	chr1	87259055	87259084	86793372	86793401	4210	hg19	N/A	enh26935	fant2229	Enhatls8209	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05708		-0.49715			SH3GLB1	chr1	86704569	86748184	44898	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7572
enhrx-7596	chr1	88150468	88150495	87684785	87684812	4211	hg19	N/A	enh12018	N/A	Enhatls8237	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.456996		0.58854			LMO4	chr1	87328879	87348923	332580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7595
enhrx-7596	chr1	88150706	88150733	87685023	87685050	4212	hg19	N/A	enh12018	fant2247	Enhatls8237	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.99987		0.30164			LMO4	chr1	87328879	87348923	335952	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7595
enhrx-7596	chr1	88150706	88150733	87685023	87685050	4213	hg19	N/A	enh12018	N/A	Enhatls8237	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.99987		0.30164			LMO4	chr1	87328879	87348923	336127	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7595
enhrx-7596	chr1	88152146	88152174	87686463	87686491	4214	hg19	N/A	enh12018	N/A	Enhatls8237	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-6.07319		-1.2879			LMO4	chr1	87328879	87348923	336127	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7595
enhrx-7800	chr1	92166994	92167021	91701437	91701464	4215	hg19	N/A	enh26956	N/A	Enhatls8437	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.01518		-0.88269			TGFBR3	chr1	91680342	91906335	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7799
enhrx-7985	chr1	94135675	94135703	93670119	93670147	4216	hg19	N/A	enh12057	N/A	Enhatls8636	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.946491		0.29113			BCAR3	chr1	93561740	93847150	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7984
enhrx-8099	chr1	95463481	95463509	94997925	94997953	4217	hg19	N/A	enh26979	N/A	Enhatls8775	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30233		-0.54544			ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8098
enhrx-8189	chr1	99170274	99170303	98704718	98704747	4218	hg19	N/A	enh49915	N/A	Enhatls8874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.91799		-0.66666			SNX7	chr1	98661700	98760500	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8188
enhrx-8363	chr1	101614616	101614650	101149060	101149094	4219	hg19	N/A	enh49923	N/A	Enhatls9058	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.41305		-0.56724			S1PR1	chr1	101236864	101241518	83819	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8362
enhrx-8363	chr1	101615991	101616019	101150435	101150463	4220	hg19	N/A	enh49923	N/A	Enhatls9058	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73028		-0.6297			S1PR1	chr1	101236864	101241518	83819	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8362
enhrx-8363	chr1	101620910	101620939	101155354	101155383	4221	hg19	N/A	N/A	N/A	Enhatls9058	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40752		-0.56615			S1PR1	chr1	101236864	101241518	77196	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8362
enhrx-10072	chr1	150146129	150146156	150173909	150173936	4222	hg19	N/A	enh49976	N/A	Enhatls11272	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.681606		0.43587			PLEKHO1	chr1	150149182	150160065	11082	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10071
enhrx-10150	chr1	150577437	150577460	150604961	150604984	4223	hg19	N/A	enh12245	fant3059	Enhatls11353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79932		-0.4464			ENSA	chr1	150600850	150629612	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10149
enhrx-10380	chr1	151519362	151519390	151546886	151546914	4224	hg19	N/A	enh12251	N/A	Enhatls11580	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29558		-0.54411			TUFT1	chr1	151540304	151583583	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10379
enhrx-11951	chr1	162115420	162115461	162145630	162145671	4225	hg19	N/A	enh67137	N/A	Enhatls13242	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.84014		-0.65133			NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11950
enhrx-11952	chr1	162163392	162163418	162193602	162193628	4226	hg19	N/A	enh12327	N/A	Enhatls13243	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81933		-0.45034			NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11951
enhrx-11952	chr1	162164524	162164552	162194734	162194762	4227	hg19	N/A	enh12327	N/A	Enhatls13243	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76789		-0.44021			NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11951
enhrx-11952	chr1	162219056	162219086	162249266	162249296	4228	hg19	N/A	enh50003	N/A	Enhatls13243	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06739		-0.49918			NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11951
enhrx-11957	chr1	162320322	162320345	162350532	162350555	4229	hg19	N/A	enh27168	N/A	Enhatls13248	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.70105		-0.42705			NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11956
enhrx-12039	chr1	164581152	164581181	164611915	164611944	4230	hg19	N/A	enh12334	fant3511	Enhatls13336	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.75636		-0.43794			PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12038
enhrx-12039	chr1	164581183	164581212	164611946	164611975	4231	hg19	N/A	enh12334	fant3511	Enhatls13336	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7526		-0.4372			PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12038
enhrx-12039	chr1	164640261	164640289	164671024	164671052	4232	hg19	N/A	enh12337	N/A	Enhatls13336	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71136		-0.42908			PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12038
enhrx-12039	chr1	164658307	164658335	164689070	164689098	4233	hg19	N/A	enh12338	N/A	Enhatls13336	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	6.081549		1.1053			PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12038
enhrx-12153	chr1	167074772	167074796	167105535	167105559	4234	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.90019		-0.46626			GPA33	chr1	167052835	167166479	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12152
enhrx-12153	chr1	167074772	167074796	167105535	167105559	4235	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.90019		-0.46626			STYXL2	chr1	167094074	167129165	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12152
enhrx-12295	chr1	168799368	168799395	168830130	168830157	4236	hg19	N/A	enh50020	N/A	Enhatls13618	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.227606		0.34648			DPT	chr1	168695467	168729206	93070	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12294
enhrx-12604	chr1	172466342	172466382	172497202	172497242	4237	hg19	N/A	enh12373	N/A	Enhatls13939	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72525		-0.62871			C1orf105	chr1	172420684	172468831	26395	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12603
enhrx-12604	chr1	172466405	172466436	172497265	172497296	4238	hg19	N/A	enh12373	N/A	Enhatls13939	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83665		-0.45375			C1orf105	chr1	172420684	172468831	26395	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12603
enhrx-12604	chr1	172466696	172466719	172497556	172497579	4239	hg19	N/A	enh12373	fant3668	Enhatls13939	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03041		-0.4919			C1orf105	chr1	172420684	172468831	28603	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12603
enhrx-12604	chr1	172466696	172466719	172497556	172497579	4240	hg19	N/A	enh12373	N/A	Enhatls13939	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03041		-0.4919			C1orf105	chr1	172420684	172468831	28733	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12603
enhrx-12920	chr1	178030418	178030446	178061283	178061311	4241	hg19	N/A	enh12406	N/A	Enhatls14279	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.88084		-0.46245			RASAL2	chr1	178094103	178484147	29399	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12919
enhrx-12920	chr1	178030507	178030534	178061372	178061399	4242	hg19	N/A	enh12406	N/A	Enhatls14279	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.97721		-0.67832			RASAL2	chr1	178094103	178484147	29399	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12919
enhrx-13410	chr1	183811783	183811811	183842649	183842677	4243	hg19	N/A	enh27305	N/A	Enhatls14807	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11		-0.50757			RGL1	chr1	183636084	183928532	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	13409
enhrx-13410	chr1	183811783	183811811	183842649	183842677	4244	hg19	N/A	enh27305	fant3945	Enhatls14807	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11		-0.50757			RGL1	chr1	183636084	183928532	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	13409
enhrx-13719	chr1	192508994	192509023	192539864	192539893	4245	hg19	N/A	enh834	fant4099	Enhatls15141	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.62401		-0.80567			RGS1	chr1	192575772	192580024	35753	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	13718
enhrx-14016	chr1	198861316	198861343	198892187	198892214	4246	hg19	N/A	enh67232	N/A	Enhatls15443	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.34855		-0.55454			PTPRC	chr1	198638456	198757476	131201	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	14015
enhrx-14029	chr1	200209990	200210019	200240862	200240891	4247	hg19	N/A	enh64150	N/A	Enhatls15457	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.377105		0.57281			NR5A2	chr1	200027613	200177420	61298	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	14028
enhrx-14608	chr1	204473611	204473646	204504483	204504518	4248	hg19	N/A	enh886	N/A	Enhatls16096	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18511		-0.52236			PIK3C2B	chr1	204422627	204494805	2313	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	14607
enhrx-14608	chr1	204475709	204475742	204506581	204506614	4249	hg19	N/A	enh886	N/A	Enhatls16096	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30538		-0.54604			PIK3C2B	chr1	204422627	204494805	2313	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	14607
enhrx-14608	chr1	204476144	204476170	204507016	204507042	4250	hg19	N/A	enh886	N/A	Enhatls16096	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.90222		-0.46666			PIK3C2B	chr1	204422627	204494805	2313	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	14607
enhrx-15106	chr1	208353344	208353372	208179999	208180027	4251	hg19	N/A	enh12612	N/A	Enhatls16625	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.77198		-1.0317			PLXNA2	chr1	208022241	208244384	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15105
enhrx-15329	chr1	212659423	212659450	212486081	212486108	4252	hg19	N/A	enh12641	fant4719	Enhatls16858	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.96576		-0.47917			NENF	chr1	212432919	212446379	39334	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15328
enhrx-15329	chr1	212659481	212659508	212486139	212486166	4253	hg19	N/A	enh12641	fant4719	Enhatls16858	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.31813		-0.54855			NENF	chr1	212432919	212446379	39334	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15328
enhrx-15329	chr1	212659510	212659537	212486168	212486195	4254	hg19	N/A	enh12641	fant4719	Enhatls16858	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.65494		-0.81176			NENF	chr1	212432919	212446379	39334	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15328
enhrx-15329	chr1	212662144	212662168	212488802	212488826	4255	hg19	N/A	enh12641	fant4720	Enhatls16858	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.549504		0.40986			NENF	chr1	212432919	212446379	42126	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15328
enhrx-15396	chr1	213550849	213550878	213377506	213377535	4256	hg19	N/A	enh50183	N/A	Enhatls16923	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.055179		0.31253			RPS6KC1	chr1	213051232	213274774	97747	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15395
enhrx-15519	chr1	216356815	216356843	216183473	216183501	4257	hg19	N/A	enh67274	N/A	Enhatls17053	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73066		-0.43288			USH2A	chr1	215622890	216423448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15518
enhrx-15519	chr1	216357586	216357614	216184244	216184272	4258	hg19	N/A	enh67274	N/A	Enhatls17053	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7047		-0.42777			USH2A	chr1	215622890	216423448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15518
enhrx-15519	chr1	216357616	216357644	216184274	216184302	4259	hg19	N/A	enh67274	N/A	Enhatls17053	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46491		-0.57745			USH2A	chr1	215622890	216423448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15518
enhrx-15548	chr1	217062215	217062244	216888873	216888902	4260	hg19	N/A	N/A	N/A	Enhatls17083	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09263		-0.50415			ESRRG	chr1	216503245	217137755	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15547
enhrx-15548	chr1	217062246	217062275	216888904	216888933	4261	hg19	N/A	N/A	N/A	Enhatls17083	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30431		-0.54583			ESRRG	chr1	216503245	217137755	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15547
enhrx-15548	chr1	217100269	217100302	216926927	216926960	4262	hg19	N/A	enh922	N/A	Enhatls17083	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.45374		-0.57525			ESRRG	chr1	216503245	217137755	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	15547
enhrx-16027	chr1	225791387	225791409	225603685	225603707	4263	hg19	N/A	enh43160	N/A	Enhatls17590	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.94014		-0.67102			ENAH	chr1	225486764	225653142	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	16026
enhrx-16681	chr1	234984088	234984127	234848341	234848380	4264	hg19	N/A	enh995	N/A	Enhatls18291	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	4.130098		0.72107			IRF2BP2	chr1	234604268	234610178	235547	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	16680
enhrx-16816	chr1	236147459	236147489	235984159	235984189	4265	hg19	N/A	N/A	N/A	Enhatls18418	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.266358		0.35411			NID1	chr1	235975829	236065109	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	16815
enhrx-17252	chr1	243633963	243633990	243470661	243470688	4266	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.34906		-0.55464			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-17252	chr1	243634461	243634488	243471159	243471186	4267	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98008		-0.48199			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-17252	chr1	243634549	243634577	243471247	243471275	4268	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67997		-0.4229			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-17252	chr1	243636889	243636917	243473587	243473615	4269	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29055		-0.54312			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-17252	chr1	243636977	243637005	243473675	243473703	4270	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40452		-0.56556			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-17252	chr1	243637944	243637978	243474642	243474676	4271	hg19	N/A	enh1012	N/A	Enhatls18872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.88343		-0.46296			SDCCAG8	chr1	243256040	243500091	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	17251
enhrx-88264	chr2	6587265	6587294	6447133	6447162	4272	hg19	N/A	N/A	N/A	Enhatls94522	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.82927		-0.64919			CMPK2	chr2	6840569	6865907	388337	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	190
enhrx-88301	chr2	8399986	8400014	8259856	8259884	4273	hg19	N/A	enh5276	N/A	Enhatls94575	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.117598		0.32482			ID2	chr2	8678844	8684461	418130	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	227
enhrx-88517	chr2	11024726	11024761	10884600	10884635	4274	hg19	N/A	enh52944	N/A	Enhatls94825	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30137		-0.54525			KCNF1	chr2	10911933	10914225	27110	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	443
enhrx-88630	chr2	12538206	12538233	12398080	12398107	4275	hg19	N/A	enh18277	fant6012	Enhatls94951	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.68061		-0.61992			TRIB2	chr2	12716934	12742734	318833	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	556
enhrx-88630	chr2	12538206	12538233	12398080	12398107	4276	hg19	N/A	enh18277	N/A	Enhatls94951	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.68061		-0.61992			TRIB2	chr2	12716934	12742734	315426	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	556
enhrx-88719	chr2	16224552	16224579	16084430	16084457	4277	hg19	N/A	N/A	N/A	Enhatls95051	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15444		-0.51632			MYCN	chr2	15940549	15947007	132947	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	645
enhrx-89528	chr2	28183220	28183247	27960353	27960380	4278	hg19	N/A	enh18379	fant6366	Enhatls95882	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.82962		-0.64926			BABAM2	chr2	27889940	28338901	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1454
enhrx-89528	chr2	28183336	28183362	27960469	27960495	4279	hg19	N/A	enh18379	fant6366	Enhatls95882	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.61397		-0.6068			BABAM2	chr2	27889940	28338901	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1454
enhrx-89999	chr2	36713902	36713928	36486759	36486785	4280	hg19	N/A	enh18441	fant6531	Enhatls96407	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.04451		-0.69157			CRIM1	chr2	36355777	36551135	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1925
enhrx-90302	chr2	39720201	39720232	39493060	39493091	4281	hg19	N/A	enh5443	N/A	Enhatls96733	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.24637		-0.53442			MAP4K3	chr2	39249265	39437301	55289	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2228
enhrx-90302	chr2	39724878	39724908	39497737	39497767	4282	hg19	N/A	enh5443	N/A	Enhatls96733	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.69511		-0.81967			MAP4K3	chr2	39249265	39437301	57940	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2228
enhrx-90302	chr2	39724943	39724974	39497802	39497833	4283	hg19	N/A	enh5443	N/A	Enhatls96733	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.51105		-0.78343			MAP4K3	chr2	39249265	39437301	57940	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2228
enhrx-90302	chr2	39777662	39777689	39550521	39550548	4284	hg19	N/A	enh18470	N/A	Enhatls96735	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.32478		-0.54986			MAP4K3	chr2	39249265	39437301	107204	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2228
enhrx-90328	chr2	40471006	40471029	40243866	40243889	4285	hg19	N/A	enh33258	N/A	Enhatls96763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.90047		-0.66321			SLC8A1	chr2	40097269	40611053	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2254
enhrx-90347	chr2	42368609	42368636	42141469	42141496	4286	hg19	N/A	enh5446	fant6783	Enhatls96786	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.99466		-0.87865			EML4	chr2	42169352	42332548	27858	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2273
enhrx-90347	chr2	42368609	42368636	42141469	42141496	4287	hg19	N/A	enh5446	N/A	Enhatls96786	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.99466		-0.87865			EML4	chr2	42169352	42332548	27620	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2273
enhrx-90347	chr2	42370054	42370075	42142914	42142935	4288	hg19	N/A	enh5446	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.89786		-0.85959			EML4	chr2	42169352	42332548	26013	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2273
enhrx-90408	chr2	43683774	43683816	43456635	43456677	4289	hg19	N/A	enh18504	N/A	Enhatls96857	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.4743		-0.5793			THADA	chr2	43230850	43596038	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2334
enhrx-90653	chr2	47496389	47496426	47269250	47269287	4290	hg19	N/A	enh18543	N/A	Enhatls97129	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12173		-0.50988			EPCAM	chr2	47345157	47387020	75375	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2579
enhrx-90653	chr2	47497087	47497116	47269948	47269977	4291	hg19	N/A	enh18543	fant6987	Enhatls97129	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84849		-0.45608			EPCAM	chr2	47345157	47387020	75066	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2579
enhrx-90653	chr2	47499486	47499519	47272347	47272380	4292	hg19	N/A	enh18543	N/A	Enhatls97129	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06348		-0.49841			EPCAM	chr2	47345157	47387020	72650	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2579
enhrx-90653	chr2	47537285	47537314	47310146	47310175	4293	hg19	N/A	enh18545	N/A	Enhatls97129	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.73899		-0.82831			EPCAM	chr2	47345157	47387020	34339	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2579
enhrx-90701	chr2	48337778	48337813	48110639	48110674	4294	hg19	N/A	enh18549	N/A	Enhatls97181	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46354		-0.57718			FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2627
enhrx-90701	chr2	48338188	48338216	48111049	48111077	4295	hg19	N/A	enh18549	N/A	Enhatls97181	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.64899		-0.81059			FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2627
enhrx-90701	chr2	48338740	48338765	48111601	48111626	4296	hg19	N/A	enh18549	N/A	Enhatls97181	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9315		-0.66932			FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2627
enhrx-90701	chr2	48339037	48339073	48111898	48111934	4297	hg19	N/A	enh18549	N/A	Enhatls97181	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.62616		-0.6092			FBXO11	chr2	47789321	47906498	197349	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2627
enhrx-91280	chr2	62870281	62870320	62643146	62643185	4298	hg19	N/A	enh53115	N/A	Enhatls97799	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76621		-0.43988			EHBP1	chr2	62673850	63046487	29071	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3206
enhrx-91280	chr2	62870446	62870474	62643311	62643339	4299	hg19	N/A	enh53115	N/A	Enhatls97799	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67819		-0.42255			EHBP1	chr2	62673850	63046487	29071	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3206
enhrx-91297	chr2	63219809	63219836	62992674	62992701	4300	hg19	N/A	N/A	N/A	Enhatls97817	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01172		-0.48822			EHBP1	chr2	62673850	63046487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3223
enhrx-91364	chr2	64631167	64631206	64404033	64404072	4301	hg19	N/A	enh18610	N/A	Enhatls97894	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05687		-0.49711			LGALSL	chr2	64453968	64461381	45328	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3290
enhrx-91364	chr2	64631651	64631673	64404517	64404539	4302	hg19	N/A	enh18610	N/A	Enhatls97894	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9153		-0.66613			LGALSL	chr2	64453968	64461381	45328	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3290
enhrx-91369	chr2	64698379	64698415	64471245	64471281	4303	hg19	N/A	enh18611	N/A	Enhatls97899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.33339		-0.74845			LGALSL	chr2	64453968	64461381	7451	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3295
enhrx-91729	chr2	71228393	71228414	71001263	71001284	4304	hg19	N/A	N/A	N/A	Enhatls98292	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.87853		-0.65889			TEX261	chr2	70985941	70994873	4998	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3655
enhrx-91729	chr2	71229196	71229221	71002066	71002091	4305	hg19	N/A	N/A	N/A	Enhatls98292	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83574		-0.45357			TEX261	chr2	70985941	70994873	4998	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3655
enhrx-92168	chr2	76496227	76496257	76269101	76269131	4306	hg19	N/A	enh53164	N/A	Enhatls98753	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05977		-0.49768			LRRTM4	chr2	76747684	77593196	475056	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4094
enhrx-93819	chr2	109253859	109253895	108637403	108637439	4307	hg19	hs2372	enh18792	N/A	Enhatls100480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5643		-0.59702			LIMS1	chr2	108533670	108687246	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5745
enhrx-94508	chr2	120294040	120294067	119536464	119536491	4308	hg19	N/A	enh53271	N/A	Enhatls101197	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.02155		-0.68705			CFAP221	chr2	119544448	119662251	5490	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6434
enhrx-95178	chr2	134175417	134175446	133417846	133417875	4309	hg19	N/A	enh33665	N/A	Enhatls101909	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66334		-0.61652			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7104
enhrx-95178	chr2	134177316	134177351	133419745	133419780	4310	hg19	N/A	enh33665	N/A	Enhatls101909	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.14971		-0.51539			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7104
enhrx-95178	chr2	134180496	134180524	133422925	133422953	4311	hg19	N/A	enh33665	N/A	Enhatls101909	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91685		-0.46954			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7104
enhrx-95178	chr2	134180811	134180840	133423240	133423269	4312	hg19	N/A	enh33665	N/A	Enhatls101909	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06937		-0.49957			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7104
enhrx-95178	chr2	134180842	134180871	133423271	133423300	4313	hg19	N/A	enh33665	N/A	Enhatls101909	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39279		-0.56325			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7104
enhrx-95179	chr2	134255373	134255399	133497802	133497828	4314	hg19	N/A	enh33667	N/A	Enhatls101910	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.441375		0.38857			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7105
enhrx-95179	chr2	134262148	134262176	133504577	133504605	4315	hg19	N/A	enh33667	N/A	Enhatls101910	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.97681		-0.67824			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7105
enhrx-95179	chr2	134262477	134262505	133504906	133504934	4316	hg19	N/A	enh33667	N/A	Enhatls101910	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.92724		-0.66848			NCKAP5	chr2	132671787	133568463	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7105
enhrx-95180	chr2	134517750	134517780	133760179	133760209	4317	hg19	N/A	enh33676	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.059016		0.51018			NCKAP5	chr2	132671787	133568463	177332	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134523373	134523400	133765802	133765829	4318	hg19	N/A	enh62847	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73546		-0.63072			NCKAP5	chr2	132671787	133568463	195255	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134523431	134523459	133765860	133765888	4319	hg19	N/A	enh62847	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.82777		-0.84579			NCKAP5	chr2	132671787	133568463	195255	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134532145	134532174	133774574	133774603	4320	hg19	N/A	enh33677	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57619		-0.59936			NCKAP5	chr2	132671787	133568463	203472	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134532327	134532356	133774756	133774785	4321	hg19	N/A	enh33677	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.69397		-0.62255			NCKAP5	chr2	132671787	133568463	203472	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134535130	134535157	133777559	133777586	4322	hg19	N/A	enh33677	N/A	Enhatls101913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.97762		-0.6784			NCKAP5	chr2	132671787	133568463	203472	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95180	chr2	134918897	134918938	134161326	134161367	4323	hg19	N/A	enh5870	N/A	Enhatls101914	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16876		-0.51914			MGAT5	chr2	134120181	134454621	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7106
enhrx-95290	chr2	136424156	136424183	135666586	135666613	4324	hg19	N/A	enh33690	N/A	Enhatls102028	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1262		-0.51076			R3HDM1	chr2	135531483	135725270	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7216
enhrx-95531	chr2	144283973	144283998	143526404	143526429	4325	hg19	N/A	enh18890	N/A	Enhatls102270	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.70113		-0.62396			ARHGAP15	chr2	143091361	143768352	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7457
enhrx-95673	chr2	151733141	151733170	150876627	150876656	4326	hg19	N/A	enh53352	N/A	Enhatls102435	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98013		-0.482			RND3	chr2	150468194	150539011	328218	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7599
enhrx-96034	chr2	159047770	159047796	158191258	158191284	4327	hg19	N/A	enh76440	N/A	Enhatls102802	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.95619		-0.67418			CCDC148	chr2	158171072	158456753	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7960
enhrx-96227	chr2	161329399	161329427	160472888	160472916	4328	hg19	N/A	enh18955	N/A	Enhatls103013	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.37644		-0.95382			RBMS1	chr2	160272150	160493807	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8153
enhrx-96229	chr2	161523395	161523421	160666884	160666910	4329	hg19	N/A	enh33887	N/A	Enhatls103014	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.02477		-0.49079			RBMS1	chr2	160272150	160493807	173036	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8155
enhrx-96229	chr2	161694830	161694860	160838319	160838349	4330	hg19	N/A	enh18964	N/A	Enhatls103014	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22752		-0.53071			TANK	chr2	161136907	161236230	296444	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8155
enhrx-96373	chr2	164202550	164202576	163346040	163346066	4331	hg19	N/A	enh33896	N/A	Enhatls103164	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.33245		-0.55137			FIGN	chr2	163593395	163736012	245208	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8299
enhrx-96373	chr2	164205248	164205275	163348738	163348765	4332	hg19	N/A	enh33896	N/A	Enhatls103164	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.63797		-0.80842			FIGN	chr2	163593395	163736012	244327	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8299
enhrx-96912	chr2	171680251	171680276	170823741	170823766	4333	hg19	N/A	N/A	N/A	Enhatls103726	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80105		-0.44674			GAD1	chr2	170813212	170861151	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8838
enhrx-96912	chr2	171680278	171680304	170823768	170823794	4334	hg19	N/A	N/A	N/A	Enhatls103726	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.61108		-0.60623			GAD1	chr2	170813212	170861151	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8838
enhrx-96963	chr2	172272657	172272684	171416147	171416174	4335	hg19	N/A	N/A	N/A	Enhatls103778	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.57434		-0.79589			METTL8	chr2	171315745	171434802	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8889
enhrx-97116	chr2	174420612	174420639	173555884	173555911	4336	hg19	N/A	enh33969	N/A	Enhatls103949	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.89621		-0.66237			CDCA7	chr2	173354819	173368997	182701	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9042
enhrx-97116	chr2	174421053	174421081	173556325	173556353	4337	hg19	N/A	enh33969	N/A	Enhatls103949	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.35991		-0.75367			CDCA7	chr2	173354819	173368997	182701	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9042
enhrx-97255	chr2	177383669	177383699	176518941	176518971	4338	hg19	N/A	enh5991	N/A	Enhatls104089	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.48429		-0.77816			MTX2	chr2	176269441	176338025	175302	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9181
enhrx-97255	chr2	177392095	177392124	176527367	176527396	4339	hg19	N/A	enh76473	N/A	Enhatls104089	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.58429		-0.79785			MTX2	chr2	176269441	176338025	186553	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9181
enhrx-97808	chr2	188167521	188167548	187302794	187302821	4340	hg19	N/A	enh44954	N/A	Enhatls104659	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.18339		-0.91581			CALCRL	chr2	187341963	187448460	37576	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9734
enhrx-97909	chr2	190075546	190075586	189210820	189210860	4341	hg19	N/A	enh34058	N/A	Enhatls104763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17272		-0.51992			COL5A2	chr2	189031897	189225312	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9835
enhrx-97909	chr2	190075546	190075586	189210820	189210860	4342	hg19	N/A	enh34058	fant9526	Enhatls104763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17272		-0.51992			COL5A2	chr2	189031897	189225312	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9835
enhrx-97909	chr2	190276757	190276786	189412031	189412060	4343	hg19	N/A	enh34069	fant9540	Enhatls104763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68667		-0.42422			WDR75	chr2	189441473	189475552	29301	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9835
enhrx-97909	chr2	190277319	190277360	189412593	189412634	4344	hg19	N/A	enh34069	N/A	Enhatls104763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71872		-0.43053			WDR75	chr2	189441473	189475552	26425	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9835
enhrx-98257	chr2	197265017	197265043	196400293	196400319	4345	hg19	N/A	enh34120	fant9685	Enhatls105126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6707		-0.61797			HECW2	chr2	196194071	196593554	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10183
enhrx-98448	chr2	200852555	200852583	199987832	199987860	4346	hg19	N/A	enh48394	N/A	Enhatls105327	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.39785		-0.76114			MAIP1	chr2	199955316	200008540	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10374
enhrx-98448	chr2	200998107	200998133	200133384	200133410	4347	hg19	N/A	enh34138	N/A	Enhatls105327	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.365599		0.37365			MAIP1	chr2	199955316	200008540	114543	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10374
enhrx-98448	chr2	201002908	201002938	200138185	200138215	4348	hg19	N/A	enh70123	N/A	Enhatls105327	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.483254		0.59371			MAIP1	chr2	199955316	200008540	125423	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10374
enhrx-98448	chr2	201003259	201003286	200138536	200138563	4349	hg19	N/A	enh70123	N/A	Enhatls105327	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91172		-0.46853			MAIP1	chr2	199955316	200008540	125423	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10374
enhrx-98448	chr2	201023672	201023700	200158949	200158977	4350	hg19	N/A	enh44965	N/A	Enhatls105327	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8426		-0.45492			SPATS2L	chr2	200305880	200482264	144329	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10374
enhrx-98450	chr2	201182377	201182405	200317654	200317682	4351	hg19	N/A	enh19112	N/A	Enhatls105328	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.299218		0.36058			SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10376
enhrx-98450	chr2	201183298	201183327	200318575	200318604	4352	hg19	N/A	enh19112	N/A	Enhatls105328	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69536		-0.42593			SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10376
enhrx-98450	chr2	201185338	201185362	200320615	200320639	4353	hg19	N/A	enh19112	N/A	Enhatls105328	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.86489		-0.45931			SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10376
enhrx-98450	chr2	201187406	201187435	200322683	200322712	4354	hg19	N/A	enh19112	N/A	Enhatls105328	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95758		-0.47756			SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10376
enhrx-98450	chr2	201187498	201187527	200322775	200322804	4355	hg19	N/A	enh19112	N/A	Enhatls105328	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.088344		0.31906			SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10376
enhrx-98719	chr2	202929172	202929200	202064449	202064477	4356	hg19	N/A	enh34153	N/A	Enhatls105633	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.3256		-0.55002			KIAA2012	chr2	202073254	202205188	6403	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10645
enhrx-98719	chr2	202929344	202929373	202064621	202064650	4357	hg19	N/A	enh34153	N/A	Enhatls105633	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84275		-0.45495			KIAA2012	chr2	202073254	202205188	6403	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10645
enhrx-98719	chr2	202929436	202929465	202064713	202064742	4358	hg19	N/A	enh34153	N/A	Enhatls105633	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83508		-0.45344			KIAA2012	chr2	202073254	202205188	6403	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10645
enhrx-98905	chr2	204672789	204672823	203808066	203808100	4359	hg19	N/A	enh19133	N/A	Enhatls105825	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.0167		-0.4892			CTLA4	chr2	203853887	203873965	45761	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10831
enhrx-98905	chr2	204672958	204672985	203808235	203808262	4360	hg19	N/A	enh19133	fant9843	Enhatls105825	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11894		-0.50933			CTLA4	chr2	203853887	203873965	45442	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10831
enhrx-98905	chr2	204673185	204673214	203808462	203808491	4361	hg19	N/A	enh19133	N/A	Enhatls105825	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.081109		0.51453			CTLA4	chr2	203853887	203873965	42131	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10831
enhrx-98924	chr2	205999887	205999914	205135163	205135190	4362	hg19	N/A	N/A	N/A	Enhatls105843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97901		-0.48178			PARD3B	chr2	204545474	205620162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10850
enhrx-98924	chr2	206004276	206004304	205139552	205139580	4363	hg19	N/A	enh70138	N/A	Enhatls105843	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.753195		0.64686			PARD3B	chr2	204545474	205620162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10850
enhrx-98924	chr2	206004780	206004808	205140056	205140084	4364	hg19	N/A	enh70138	N/A	Enhatls105843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.38759		-0.75912			PARD3B	chr2	204545474	205620162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10850
enhrx-98924	chr2	206004810	206004838	205140086	205140114	4365	hg19	N/A	enh70138	N/A	Enhatls105843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6624		-0.41944			PARD3B	chr2	204545474	205620162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10850
enhrx-98924	chr2	206009444	206009470	205144720	205144746	4366	hg19	N/A	N/A	N/A	Enhatls105843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71202		-0.42921			PARD3B	chr2	204545474	205620162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10850
enhrx-98949	chr2	206795179	206795207	205930455	205930483	4367	hg19	N/A	enh53531	N/A	Enhatls105874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07389		-0.50046			INO80D	chr2	205993720	206086303	61236	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10875
enhrx-99228	chr2	210805708	210805747	209940984	209941023	4368	hg19	N/A	N/A	N/A	Enhatls106161	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.96157		-0.67524			UNC80	chr2	209771831	209999300	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11154
enhrx-99513	chr2	216489387	216489414	215624664	215624691	4369	hg19	N/A	enh6144	fant10019	Enhatls106461	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80156		-0.44684			FN1	chr2	215360439	215436073	188488	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11439
enhrx-99513	chr2	216638004	216638032	215773281	215773309	4370	hg19	N/A	enh34244	N/A	Enhatls106465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.94971		-0.47601			MREG	chr2	215942583	216034096	168933	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11439
enhrx-99513	chr2	216638482	216638511	215773759	215773788	4371	hg19	N/A	enh34244	fant10033	Enhatls106465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00014		-0.48594			MREG	chr2	215942583	216034096	168454	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11439
enhrx-99513	chr2	216638700	216638729	215773977	215774006	4372	hg19	N/A	enh34244	fant10033	Enhatls106465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8652		-0.45937			MREG	chr2	215942583	216034096	168454	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11439
enhrx-99576	chr2	217508811	217508839	216644088	216644116	4373	hg19	N/A	enh19218	N/A	Enhatls106534	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.4356		-0.57168			IGFBP2	chr2	216632827	216664436	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11502
enhrx-99583	chr2	217797359	217797385	216932636	216932662	4374	hg19	N/A	enh44993	fant10073	Enhatls106542	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.393482		0.37914			TNP1	chr2	216859457	216860064	72330	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11509
enhrx-99583	chr2	217797674	217797701	216932951	216932978	4375	hg19	N/A	enh44993	N/A	Enhatls106542	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.15734		-0.91068			TNP1	chr2	216859457	216860064	72678	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11509
enhrx-100052	chr2	223574221	223574247	222709502	222709528	4376	hg19	N/A	enh19255	N/A	Enhatls107043	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.34672		-0.55418			MOGAT1	chr2	222671657	222709930	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	11978
enhrx-100181	chr2	227272050	227272077	226407334	226407361	4377	hg19	N/A	enh34356	N/A	Enhatls107182	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.693033		0.43812			IRS1	chr2	226731311	226799820	321296	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12107
enhrx-100181	chr2	227509232	227509269	226644516	226644553	4378	hg19	N/A	enh19283	N/A	Enhatls107182	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75943		-0.63544			IRS1	chr2	226731311	226799820	78868	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12107
enhrx-100181	chr2	227517189	227517217	226652473	226652501	4379	hg19	N/A	enh19283	fant10368	Enhatls107182	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.30201		-0.74227			IRS1	chr2	226731311	226799820	78532	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12107
enhrx-100181	chr2	227558611	227558640	226693895	226693924	4380	hg19	N/A	enh53599	N/A	Enhatls107183	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.44571		-0.57367			IRS1	chr2	226731311	226799820	32939	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12107
enhrx-100182	chr2	227603604	227603631	226738888	226738915	4381	hg19	N/A	enh34361	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.95461		-0.67387			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227604212	227604240	226739496	226739524	4382	hg19	N/A	enh34361	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.91368		-1.0596			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227607348	227607375	226742632	226742659	4383	hg19	N/A	enh34361	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84945		-0.45627			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227625173	227625202	226760457	226760486	4384	hg19	N/A	enh6179	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.87945		-0.65907			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227637026	227637059	226772310	226772343	4385	hg19	N/A	enh6179	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75628		-0.63482			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227637433	227637461	226772717	226772745	4386	hg19	N/A	enh6179	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.85956		-0.45826			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227638045	227638074	226773329	226773358	4387	hg19	N/A	enh6179	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.93925		-0.47395			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100182	chr2	227645283	227645312	226780567	226780596	4388	hg19	N/A	enh34362	N/A	Enhatls107184	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.10432		-0.90024			IRS1	chr2	226731311	226799820	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12108
enhrx-100938	chr2	236844287	236844315	235935643	235935671	4389	hg19	N/A	enh19371	N/A	Enhatls107976	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.99443		-0.68171			AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12864
enhrx-100943	chr2	236990708	236990737	236082064	236082093	4390	hg19	N/A	enh57792	N/A	Enhatls107981	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.827166		0.46453			AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12869
enhrx-100943	chr2	236990800	236990829	236082156	236082185	4391	hg19	N/A	enh57792	N/A	Enhatls107981	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	4.122378		0.71955			AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	12869
enhrx-112102	chr3	8486237	8486263	8444551	8444577	4392	hg19	N/A	enh20308	N/A	Enhatls119959	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.420857		0.38453			LMCD1	chr3	8501806	8574668	43050	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	231
enhrx-112162	chr3	9350411	9350432	9308727	9308748	4393	hg19	N/A	N/A	N/A	Enhatls120028	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40604		-0.56586			THUMPD3	chr3	9362970	9386791	53850	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	291
enhrx-112162	chr3	9358712	9358739	9317028	9317055	4394	hg19	N/A	enh20312	N/A	Enhatls120028	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99811		-0.48554			THUMPD3	chr3	9362970	9386791	43620	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	291
enhrx-113215	chr3	29213174	29213202	29171683	29171711	4395	hg19	N/A	enh35293	N/A	Enhatls121142	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.77865		-0.44233			RBMS3	chr3	28576174	30010391	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1344
enhrx-113963	chr3	42221031	42221065	42179539	42179573	4396	hg19	N/A	enh20532	fant11786	Enhatls121953	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81685		-0.44985			TRAK1	chr3	42013801	42225890	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2092
enhrx-115168	chr3	50553282	50553321	50515851	50515890	4397	hg19	N/A	enh20592	N/A	Enhatls123216	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95357		-0.47677			CACNA2D2	chr3	50362612	50504244	6694	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3297
enhrx-115978	chr3	57934703	57934732	57948976	57949005	4398	hg19	N/A	enh20645	N/A	Enhatls124085	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2036		-0.526			SLMAP	chr3	57756229	57930003	17172	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4107
enhrx-115978	chr3	57938139	57938163	57952412	57952436	4399	hg19	N/A	enh20645	N/A	Enhatls124085	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11127		-0.50782			SLMAP	chr3	57756229	57930003	21709	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4107
enhrx-116097	chr3	59357741	59357780	59372015	59372054	4400	hg19	N/A	N/A	N/A	Enhatls124228	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.23377		-0.53194			CFAP20DC	chr3	58717364	59050084	321806	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4226
enhrx-116217	chr3	63934841	63934870	63949165	63949194	4401	hg19	N/A	enh7270	N/A	Enhatls124351	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.59925		-0.99769			ATXN7	chr3	63863866	64003462	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4346
enhrx-116281	chr3	64802108	64802137	64816433	64816462	4402	hg19	N/A	enh63159	N/A	Enhatls124424	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.31193		-0.54733			ADAMTS9	chr3	64515653	64688000	123799	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4410
enhrx-116307	chr3	65709490	65709514	65723815	65723839	4403	hg19	N/A	N/A	N/A	Enhatls124452	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.06752		-0.6961			MAGI1	chr3	65353524	66038918	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4436
enhrx-116307	chr3	65869239	65869265	65883564	65883590	4404	hg19	N/A	enh35500	N/A	Enhatls124452	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56537		-0.59723			MAGI1	chr3	65353524	66038918	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4436
enhrx-116307	chr3	65953480	65953510	65967805	65967835	4405	hg19	N/A	enh20668	N/A	Enhatls124456	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.48309		-0.58103			MAGI1	chr3	65353524	66038918	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4436
enhrx-116328	chr3	66848820	66848847	66798396	66798423	4406	hg19	N/A	enh76941	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.85032		-0.45644			KBTBD8	chr3	66998306	67011210	197816	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66850154	66850196	66799730	66799772	4407	hg19	N/A	enh76941	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.96428		-0.47888			KBTBD8	chr3	66998306	67011210	197816	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66854366	66854393	66803942	66803969	4408	hg19	N/A	enh76942	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.74391		-0.43549			KBTBD8	chr3	66998306	67011210	192316	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66854395	66854423	66803971	66803999	4409	hg19	N/A	enh76942	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6285		-0.60966			KBTBD8	chr3	66998306	67011210	192316	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66854608	66854641	66804184	66804217	4410	hg19	N/A	enh76942	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99887		-0.48569			KBTBD8	chr3	66998306	67011210	192316	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66859339	66859365	66808915	66808941	4411	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.051522		0.31181			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66861129	66861165	66810705	66810741	4412	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67382		-0.42169			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66866643	66866667	66816219	66816243	4413	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.02736		-0.4913			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66868875	66868910	66818451	66818486	4414	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1907		-0.52346			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66870691	66870719	66820267	66820295	4415	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.63911		-0.61175			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66870752	66870780	66820328	66820356	4416	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.22019		-0.72616			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66873649	66873690	66823225	66823266	4417	hg19	N/A	enh7284	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.13844		-0.51317			KBTBD8	chr3	66998306	67011210	172516	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116328	chr3	66981836	66981864	66931412	66931440	4418	hg19	N/A	enh7288	N/A	Enhatls124489	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38456		-0.56163			KBTBD8	chr3	66998306	67011210	59056	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4457
enhrx-116458	chr3	71218408	71218435	71169257	71169284	4419	hg19	N/A	enh7310	N/A	Enhatls124627	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36328		-0.55744			FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4587
enhrx-116460	chr3	71307478	71307506	71258327	71258355	4420	hg19	N/A	enh7314	N/A	Enhatls124630	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36176		-0.55714			FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4589
enhrx-116565	chr3	77019383	77019411	76970232	76970260	4421	hg19	N/A	enh35564	N/A	Enhatls124746	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79115		-0.44479			ROBO2	chr3	75906694	77649964	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4694
enhrx-116698	chr3	86841096	86841126	86791946	86791976	4422	hg19	N/A	enh20715	N/A	Enhatls124883	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.873457		0.27675			VGLL3	chr3	86937972	86991149	144192	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4827
enhrx-116728	chr3	88874025	88874053	88824875	88824903	4423	hg19	N/A	enh113214	N/A	Enhatls124915	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22864		-0.53093			EPHA3	chr3	89107620	89482134	280196	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4857
enhrx-116795	chr3	96169080	96169114	96450236	96450270	4424	hg19	N/A	enh54252	N/A	Enhatls124984	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.54658		-0.59353			EPHA6	chr3	96814580	97761532	362510	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4924
enhrx-116920	chr3	99370800	99370829	99651956	99651985	4425	hg19	N/A	enh63180	N/A	Enhatls125113	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.854947		0.47			COL8A1	chr3	99638474	99799226	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5049
enhrx-116928	chr3	99647837	99647863	99928993	99929019	4426	hg19	N/A	N/A	N/A	Enhatls125126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72749		-0.62915			CMSS1	chr3	99817836	100181732	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5057
enhrx-116928	chr3	99647837	99647863	99928993	99929019	4427	hg19	N/A	N/A	N/A	Enhatls125126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72749		-0.62915			FILIP1L	chr3	99828810	100114513	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5057
enhrx-116930	chr3	99650144	99650173	99931300	99931329	4428	hg19	N/A	N/A	N/A	Enhatls125128	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12188		-0.50991			FILIP1L	chr3	99828810	100114513	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5059
enhrx-116930	chr3	99650144	99650173	99931300	99931329	4429	hg19	N/A	N/A	N/A	Enhatls125128	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12188		-0.50991			CMSS1	chr3	99817836	100181732	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5059
enhrx-116930	chr3	99804960	99804988	100086116	100086144	4430	hg19	N/A	enh35669	N/A	Enhatls125130	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.77978		0.4552			CMSS1	chr3	99817836	100181732	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5059
enhrx-116930	chr3	99804960	99804988	100086116	100086144	4431	hg19	N/A	enh35669	N/A	Enhatls125130	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.77978		0.4552			FILIP1L	chr3	99828810	100114513	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5059
enhrx-117166	chr3	105850428	105850459	106131581	106131612	4432	hg19	N/A	enh20771	N/A	Enhatls125387	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86639		-0.6565			CBLB	chr3	105655460	105869552	259027	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5295
enhrx-117202	chr3	107676121	107676149	107957274	107957302	4433	hg19	N/A	enh20791	N/A	Enhatls125432	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.683891		0.43632			CD47	chr3	108043090	108091862	84313	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5331
enhrx-117202	chr3	107685701	107685743	107966854	107966896	4434	hg19	N/A	enh20792	N/A	Enhatls125432	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6929		-0.62234			CD47	chr3	108043090	108091862	69863	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5331
enhrx-117202	chr3	107690172	107690205	107971325	107971358	4435	hg19	N/A	enh20792	N/A	Enhatls125432	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.77642		-0.44189			CD47	chr3	108043090	108091862	69863	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5331
enhrx-117393	chr3	110799432	110799473	111080585	111080626	4436	hg19	N/A	enh54294	N/A	Enhatls125632	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56466		-0.59709			NECTIN3	chr3	111070070	111275563	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5522
enhrx-117722	chr3	114379866	114379894	114661019	114661047	4437	hg19	N/A	enh113260	N/A	Enhatls125993	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.400592		0.38054			ZBTB20	chr3	114314499	115147292	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5851
enhrx-117734	chr3	114936933	114936963	115218086	115218116	4438	hg19	hs1648	enh35791	N/A	Enhatls126007	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39639		-0.56396			ZBTB20	chr3	114314499	115147292	70196	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5863
enhrx-118172	chr3	122611349	122611379	122892502	122892532	4439	hg19	N/A	enh20856	N/A	Enhatls126442	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12996		-0.5115			SLC49A4	chr3	122795068	122881139	11275	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6301
enhrx-118254	chr3	123441939	123441973	123723092	123723126	4440	hg19	N/A	N/A	N/A	Enhatls126534	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.7365		-0.82782			MYLK	chr3	123610048	123884332	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6383
enhrx-118295	chr3	124083951	124083984	124365104	124365137	4441	hg19	N/A	enh20871	N/A	Enhatls126574	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.33768		-0.5524			KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6424
enhrx-118296	chr3	124095072	124095105	124376225	124376258	4442	hg19	N/A	enh70833	N/A	Enhatls126575	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.152947		0.33178			KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6425
enhrx-118296	chr3	124109064	124109091	124390217	124390244	4443	hg19	N/A	enh77057	N/A	Enhatls126576	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76585		-0.43981			KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6425
enhrx-118636	chr3	127886295	127886324	128167452	128167481	4444	hg19	N/A	enh7520	N/A	Enhatls126951	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56146		-0.59646			EEFSEC	chr3	128153480	128408646	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6765
enhrx-118639	chr3	128073270	128073290	128354427	128354447	4445	hg19	N/A	enh7521	N/A	Enhatls126955	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.050862		0.31168			EEFSEC	chr3	128153480	128408646	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6768
enhrx-119981	chr3	149327670	149327700	149609883	149609913	4446	hg19	N/A	enh21022	N/A	Enhatls128363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.98674		-0.87709			WWTR1	chr3	149517234	149703273	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8110
enhrx-120235	chr3	155369653	155369691	155651864	155651902	4447	hg19	N/A	N/A	N/A	Enhatls128640	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.15883		-0.71408			PLCH1	chr3	155375579	155745071	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8364
enhrx-120235	chr3	155369986	155370012	155652197	155652223	4448	hg19	N/A	N/A	N/A	Enhatls128640	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.520606		0.40417			PLCH1	chr3	155375579	155745071	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8364
enhrx-120867	chr3	171889754	171889781	172171964	172171991	4449	hg19	N/A	enh21110	N/A	Enhatls129332	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.462199		0.39267			FNDC3B	chr3	172039577	172401669	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8996
enhrx-120867	chr3	171900089	171900110	172182299	172182320	4450	hg19	N/A	N/A	N/A	Enhatls129332	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.42057		-0.56872			FNDC3B	chr3	172039577	172401669	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8996
enhrx-120925	chr3	172566887	172566915	172849097	172849125	4451	hg19	N/A	enh59275	N/A	Enhatls129393	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30812		-0.54658			ECT2	chr3	172750681	172821474	22782	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9054
enhrx-120987	chr3	177197550	177197581	177479762	177479793	4452	hg19	N/A	enh7694	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.484241		0.39701			TBL1XR1	chr3	177019343	177228000	236275	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177209235	177209262	177491447	177491474	4453	hg19	N/A	enh7694	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81725		-0.44993			TBL1XR1	chr3	177019343	177228000	236275	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177227965	177227989	177510177	177510201	4454	hg19	N/A	N/A	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.13356		-0.51221			TBL1XR1	chr3	177019343	177228000	274448	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177234282	177234313	177516494	177516525	4455	hg19	N/A	enh21140	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.3678		-0.55833			TBL1XR1	chr3	177019343	177228000	288414	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177234349	177234381	177516561	177516593	4456	hg19	N/A	enh21140	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.32174		-0.54926			TBL1XR1	chr3	177019343	177228000	288414	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177244164	177244187	177526376	177526399	4457	hg19	N/A	enh21140	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.89133		-0.66141			TBL1XR1	chr3	177019343	177228000	288414	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177254730	177254757	177536942	177536969	4458	hg19	N/A	enh45570	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.987099		0.49602			TBL1XR1	chr3	177019343	177228000	307718	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177256327	177256357	177538539	177538569	4459	hg19	N/A	enh45570	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.075443		0.31652			TBL1XR1	chr3	177019343	177228000	307718	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177256466	177256494	177538678	177538706	4460	hg19	N/A	enh45570	N/A	Enhatls129465	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.98021		-0.67891			TBL1XR1	chr3	177019343	177228000	307718	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177259521	177259550	177541733	177541762	4461	hg19	N/A	enh45570	N/A	Enhatls129466	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.04288		-0.69125			TBL1XR1	chr3	177019343	177228000	311493	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120987	chr3	177269981	177270007	177552193	177552219	4462	hg19	N/A	enh48772	N/A	Enhatls129466	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.82718		-0.64878			TBL1XR1	chr3	177019343	177228000	315979	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9116
enhrx-120990	chr3	177802933	177802961	178085145	178085173	4463	hg19	N/A	enh36170	N/A	Enhatls129472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84265		-0.45493			KCNMB2	chr3	178272931	178844429	181685	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9119
enhrx-120990	chr3	178036908	178036934	178319120	178319146	4464	hg19	N/A	enh36174	N/A	Enhatls129472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.06269		-0.69515			KCNMB2	chr3	178272931	178844429	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9119
enhrx-120990	chr3	178036964	178036990	178319176	178319202	4465	hg19	N/A	enh36174	N/A	Enhatls129472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.52753		-0.58978			KCNMB2	chr3	178272931	178844429	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9119
enhrx-120990	chr3	178038342	178038371	178320554	178320583	4466	hg19	N/A	enh36174	N/A	Enhatls129472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.4096		-0.56656			KCNMB2	chr3	178272931	178844429	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9119
enhrx-120990	chr3	178043225	178043250	178325437	178325462	4467	hg19	N/A	enh36174	N/A	Enhatls129472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.89187		-0.85841			KCNMB2	chr3	178272931	178844429	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9119
enhrx-121672	chr3	185412565	185412602	185694777	185694814	4468	hg19	N/A	N/A	N/A	Enhatls130189	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.871425		0.27635			IGF2BP2	chr3	185643129	185825042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9801
enhrx-122026	chr3	193419945	193419973	193702156	193702184	4469	hg19	N/A	enh36280	N/A	Enhatls130592	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2005		-0.52539			OPA1	chr3	193593143	193697811	2586	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10155
enhrx-122026	chr3	193429026	193429055	193711237	193711266	4470	hg19	N/A	enh71060	N/A	Enhatls130592	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6125		-0.60651			OPA1	chr3	193593143	193697811	10755	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10155
enhrx-122026	chr3	193463028	193463062	193745239	193745273	4471	hg19	N/A	enh21238	N/A	Enhatls130592	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79694		-0.44593			OPA1	chr3	193593143	193697811	42665	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10155
enhrx-122026	chr3	193463101	193463131	193745312	193745342	4472	hg19	N/A	enh21238	N/A	Enhatls130592	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2387		-0.53291			OPA1	chr3	193593143	193697811	42665	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10155
enhrx-122026	chr3	193628853	193628880	193911064	193911091	4473	hg19	N/A	enh7792	N/A	Enhatls130592	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10522		-0.50663			OPA1	chr3	193593143	193697811	200207	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	10155
enhrx-123067	chr4	4397667	4397697	4395940	4395970	4474	hg19	N/A	enh54566	N/A	Enhatls131688	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.480663		0.5932			NSG1	chr4	4348139	4419058	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	611
enhrx-123699	chr4	18400406	18400433	18398783	18398810	4475	hg19	N/A	N/A	N/A	Enhatls132381	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.95106		-0.67317			LCORL	chr4	17841186	18021876	369242	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1243
enhrx-123738	chr4	20619895	20619923	20618272	20618300	4476	hg19	N/A	N/A	N/A	Enhatls132421	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.08125		-0.50191			SLIT2	chr4	20251904	20620561	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1282
enhrx-123803	chr4	23933326	23933355	23931703	23931732	4477	hg19	hs2346	enh54631	N/A	Enhatls132487	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11685		-0.50892			PPARGC1A	chr4	23792020	23890077	40362	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1347
enhrx-123955	chr4	26824109	26824136	26822487	26822514	4478	hg19	N/A	enh7915	N/A	Enhatls132646	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.027245		0.30703			STIM2	chr4	26857677	27025381	23265	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1499
enhrx-123955	chr4	26840297	26840322	26838675	26838700	4479	hg19	N/A	enh48817	N/A	Enhatls132646	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91187		-0.46856			STIM2	chr4	26857677	27025381	14519	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1499
enhrx-123974	chr4	30790989	30791017	30789367	30789395	4480	hg19	N/A	enh54642	N/A	Enhatls132670	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.88973		-0.4642			PCDH7	chr4	30720368	31146805	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1518
enhrx-123974	chr4	30868389	30868417	30866767	30866795	4481	hg19	N/A	enh36516	N/A	Enhatls132670	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.90771		-0.46774			PCDH7	chr4	30720368	31146805	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1518
enhrx-124100	chr4	38490787	38490815	38489166	38489194	4482	hg19	N/A	enh36546	N/A	Enhatls132804	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80003		-0.44654			KLF3	chr4	38664196	38701517	170208	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1644
enhrx-124211	chr4	39471272	39471300	39469652	39469680	4483	hg19	N/A	enh93294	N/A	Enhatls132924	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.66428		-0.8136			LIAS	chr4	39459044	39485109	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1755
enhrx-lit66	chr4	52703125	52703153	51836959	51836987	4484	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.72644		-0.43205								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-lit67	chr4	52703274	52703302	51837108	51837136	4485	hg19					enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.08888		0.51606								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-124793	chr4	53795712	53795738	52929545	52929571	4486	hg19	N/A	enh21514	N/A	Enhatls133522	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.959		-0.47784			SCFD2	chr4	52872981	53366066	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2337
enhrx-124994	chr4	57082517	57082545	56216351	56216379	4487	hg19	N/A	N/A	N/A	Enhatls133739	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.193781		0.33982			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2538
enhrx-124996	chr4	57167315	57167344	56301149	56301178	4488	hg19	N/A	N/A	N/A	Enhatls133741	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81862		-0.4502			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2540
enhrx-124996	chr4	57167407	57167436	56301241	56301270	4489	hg19	N/A	N/A	N/A	Enhatls133741	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.96952		-0.47991			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2540
enhrx-124996	chr4	57167530	57167559	56301364	56301393	4490	hg19	N/A	N/A	N/A	Enhatls133741	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95408		-0.47687			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2540
enhrx-124996	chr4	57168991	57169017	56302825	56302851	4491	hg19	N/A	N/A	N/A	Enhatls133741	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.87073		-0.46046			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2540
enhrx-124996	chr4	57169102	57169128	56302936	56302962	4492	hg19	N/A	N/A	N/A	Enhatls133741	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.65285		-0.41756			CRACD	chr4	56049097	56330609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2540
enhrx-125569	chr4	71761588	71761617	70895871	70895900	4493	hg19	N/A	N/A	N/A	Enhatls134332	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.4466		-0.77074			MOB1B	chr4	70902325	70988168	4993	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3113
enhrx-125976	chr4	77528700	77528736	76607547	76607583	4494	hg19	N/A	enh21594	N/A	Enhatls134772	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86634		-0.65649			SHROOM3	chr4	76435228	76783253	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3520
enhrx-126150	chr4	80958230	80958256	80037076	80037102	4495	hg19	N/A	enh100203	N/A	Enhatls134964	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.05243		-0.69313			ANTXR2	chr4	79901145	80125454	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3694
enhrx-126216	chr4	83206194	83206222	82285041	82285069	4496	hg19	N/A	enh100206	N/A	Enhatls135029	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36638		-0.55805			HNRNPD	chr4	82352497	82374503	64696	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3760
enhrx-126734	chr4	90494333	90494360	89573182	89573209	4497	hg19	N/A	enh54843	N/A	Enhatls135565	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.322987		0.36526			SNCA	chr4	89700344	89838315	125841	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4278
enhrx-126844	chr4	96009411	96009440	95088260	95088289	4498	hg19	N/A	enh48850	N/A	Enhatls135679	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18207		-0.52176			BMPR1B	chr4	94757954	95158448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4388
enhrx-126869	chr4	96437935	96437964	95516784	95516813	4499	hg19	N/A	enh36831	N/A	Enhatls135705	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6593		-0.41883			UNC5C	chr4	95162503	95549206	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4413
enhrx-127237	chr4	105342410	105342437	104421253	104421280	4500	hg19	N/A	N/A	N/A	Enhatls136085	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.366208		0.37377			CXXC4	chr4	104468307	104494894	45160	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4781
enhrx-127240	chr4	105423066	105423093	104501909	104501936	4501	hg19	N/A	enh65876	N/A	Enhatls136089	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.51641		-0.58759			CXXC4	chr4	104468307	104494894	5010	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4784
enhrx-127446	chr4	109799670	109799699	108878514	108878543	4502	hg19	N/A	enh36915	N/A	Enhatls136308	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92482		-0.47111			COL25A1	chr4	108808724	109302752	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4990
enhrx-127447	chr4	109806019	109806048	108884863	108884892	4503	hg19	N/A	N/A	N/A	Enhatls136309	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.06247		0.51086			COL25A1	chr4	108808724	109302752	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4991
enhrx-127447	chr4	109806050	109806080	108884894	108884924	4504	hg19	N/A	N/A	N/A	Enhatls136309	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.53817		-0.78877			COL25A1	chr4	108808724	109302752	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4991
enhrx-127447	chr4	109806144	109806174	108884988	108885018	4505	hg19	N/A	N/A	N/A	Enhatls136309	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.034384		0.50533			COL25A1	chr4	108808724	109302752	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4991
enhrx-128115	chr4	124273962	124273989	123352807	123352834	4506	hg19	N/A	enh37001	N/A	Enhatls136989	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.613701		0.4225			AFG2A	chr4	122923069	123319433	32517	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5659
enhrx-128118	chr4	124467662	124467689	123546507	123546534	4507	hg19	N/A	enh21767	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.69801		0.4391			SPRY1	chr4	123396794	123403760	139991	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124468813	124468837	123547658	123547682	4508	hg19	N/A	enh21767	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39827		-0.56433			SPRY1	chr4	123396794	123403760	139991	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124476148	124476177	123554993	123555022	4509	hg19	N/A	enh21768	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30746		-0.54645			SPRY1	chr4	123396794	123403760	147651	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124476842	124476870	123555687	123555715	4510	hg19	N/A	enh21768	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.86642		-0.45961			SPRY1	chr4	123396794	123403760	147651	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124477235	124477261	123556080	123556106	4511	hg19	N/A	enh21768	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.94303		-0.67159			SPRY1	chr4	123396794	123403760	147651	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124477263	124477289	123556108	123556134	4512	hg19	N/A	enh21768	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76052		-0.43876			SPRY1	chr4	123396794	123403760	147651	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124478113	124478137	123556958	123556982	4513	hg19	N/A	enh21768	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79653		-0.44585			SPRY1	chr4	123396794	123403760	147651	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124504427	124504455	123583272	123583300	4514	hg19	N/A	N/A	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16724		-0.51884			SPRY1	chr4	123396794	123403760	163261	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124515454	124515481	123594299	123594326	4515	hg19	N/A	N/A	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.312474		0.36319			SPRY1	chr4	123396794	123403760	188161	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124521244	124521271	123600089	123600116	4516	hg19	N/A	enh48880	fant16759	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.0906		-0.50375			SPRY1	chr4	123396794	123403760	196315	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124521361	124521388	123600206	123600233	4517	hg19	N/A	enh48880	fant16759	Enhatls136991	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.02374		-0.68748			SPRY1	chr4	123396794	123403760	196315	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124553582	124553613	123632427	123632458	4518	hg19	N/A	enh100244	N/A	Enhatls136991	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.427081		0.58265			SPRY1	chr4	123396794	123403760	226031	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124590909	124590931	123669754	123669776	4519	hg19	N/A	enh83302	N/A	Enhatls136993	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.96711		-0.67633			SPRY1	chr4	123396794	123403760	261831	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128118	chr4	124620962	124620990	123699807	123699835	4520	hg19	N/A	enh37004	N/A	Enhatls136993	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.191851		0.33944			SPRY1	chr4	123396794	123403760	294011	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5662
enhrx-128121	chr4	124857938	124857965	123936783	123936810	4521	hg19	N/A	enh95165	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29913		-0.54481			SPRY1	chr4	123396794	123403760	531031	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124861014	124861045	123939859	123939890	4522	hg19	N/A	enh95165	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36115		-0.55702			SPRY1	chr4	123396794	123403760	531031	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124897676	124897703	123976521	123976548	4523	hg19	N/A	enh54975	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6704		-0.61791			SPRY1	chr4	123396794	123403760	568731	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124907514	124907544	123986359	123986389	4524	hg19	N/A	enh21778	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25205		-0.53554			SPRY1	chr4	123396794	123403760	579271	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124907672	124907701	123986517	123986546	4525	hg19	N/A	enh21778	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.1279		-0.70799			SPRY1	chr4	123396794	123403760	579271	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124940252	124940281	124019097	124019126	4526	hg19	N/A	enh21779	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.788792		0.26008			SPRY1	chr4	123396794	123403760	610111	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	124940283	124940312	124019128	124019157	4527	hg19	N/A	enh21779	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.128467		0.32696			SPRY1	chr4	123396794	123403760	610111	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128121	chr4	125243153	125243181	124321998	124322026	4528	hg19	N/A	N/A	N/A	Enhatls136998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92538		-0.47122			ANKRD50	chr4	124664047	124712732	334118	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5665
enhrx-128126	chr4	125458906	125458942	124537751	124537787	4529	hg19	N/A	enh54978	N/A	Enhatls137003	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.296425		0.36003			ANKRD50	chr4	124664047	124712732	124828	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5670
enhrx-128126	chr4	125459341	125459366	124538186	124538211	4530	hg19	N/A	enh54978	N/A	Enhatls137003	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.178443		0.3368			ANKRD50	chr4	124664047	124712732	124828	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5670
enhrx-128126	chr4	125459496	125459517	124538341	124538362	4531	hg19	N/A	enh54978	N/A	Enhatls137003	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.13077		-0.51166			ANKRD50	chr4	124664047	124712732	124828	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5670
enhrx-128314	chr4	135545826	135545854	134624671	134624699	4532	hg19	N/A	enh54998	N/A	Enhatls137202	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.286165		0.35801			PABPC4L	chr4	134196332	134201789	418962	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5858
enhrx-128324	chr4	138585411	138585440	137664257	137664286	4533	hg19	N/A	enh21804	N/A	Enhatls137212	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29431		-0.54386			PCDH18	chr4	137518917	137532494	131009	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5868
enhrx-128324	chr4	138585505	138585535	137664351	137664381	4534	hg19	N/A	enh21804	N/A	Enhatls137212	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.77221		-0.83485			PCDH18	chr4	137518917	137532494	131009	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5868
enhrx-128324	chr4	138590607	138590633	137669453	137669479	4535	hg19	N/A	enh21804	N/A	Enhatls137212	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17755		-0.52087			PCDH18	chr4	137518917	137532494	132298	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5868
enhrx-128404	chr4	140970372	140970400	140049218	140049246	4536	hg19	N/A	enh8234	fant16940	Enhatls137303	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16688		-0.51877			MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5948
enhrx-128404	chr4	140970660	140970694	140049506	140049540	4537	hg19	N/A	enh8234	fant16940	Enhatls137303	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.88887		-0.85782			MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5948
enhrx-128404	chr4	140971663	140971696	140050509	140050542	4538	hg19	N/A	enh8234	N/A	Enhatls137303	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.72837		-0.43243			MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5948
enhrx-128514	chr4	143273263	143273288	142352110	142352135	4539	hg19	N/A	enh48883	N/A	Enhatls137417	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.10723		-0.70392			INPP4B	chr4	142023159	142847432	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6058
enhrx-128596	chr4	145291629	145291657	144370477	144370505	4540	hg19	N/A	N/A	N/A	Enhatls137501	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.556412		0.41122			GYPA	chr4	144109302	144140751	219593	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6140
enhrx-128596	chr4	145291776	145291803	144370624	144370651	4541	hg19	N/A	N/A	N/A	Enhatls137501	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-5.71005		-1.2164			GYPA	chr4	144109302	144140751	219593	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6140
enhrx-128596	chr4	145298151	145298178	144376999	144377026	4542	hg19	N/A	N/A	N/A	Enhatls137501	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15012		-0.51547			GYPA	chr4	144109302	144140751	235539	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6140
enhrx-128613	chr4	145981773	145981799	145060621	145060647	4543	hg19	N/A	N/A	N/A	Enhatls137516	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.76344		-0.63623			ANAPC10	chr4	144994574	145098541	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6157
enhrx-128614	chr4	145987289	145987315	145066137	145066163	4544	hg19	N/A	N/A	N/A	Enhatls137517	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.251934		0.35127			ANAPC10	chr4	144994574	145098541	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6158
enhrx-128614	chr4	145987327	145987355	145066175	145066203	4545	hg19	N/A	N/A	N/A	Enhatls137517	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.58838		-0.60176			ANAPC10	chr4	144994574	145098541	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6158
enhrx-128677	chr4	146724674	146724698	145803522	145803546	4546	hg19	N/A	enh21851	N/A	Enhatls137579	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.38241		-0.7581			ZNF827	chr4	145757626	145938823	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6221
enhrx-128677	chr4	146729679	146729706	145808527	145808554	4547	hg19	N/A	enh21851	fant17045	Enhatls137579	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83467		-0.45336			ZNF827	chr4	145757626	145938823	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6221
enhrx-128795	chr4	150886396	150886423	149965244	149965271	4548	hg19	N/A	N/A	N/A	Enhatls137704	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.18801		-0.91672			DCLK2	chr4	150078444	150257438	99512	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6339
enhrx-128806	chr4	151157204	151157233	150236052	150236081	4549	hg19	N/A	enh37197	N/A	Enhatls137715	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.402979		0.38101			DCLK2	chr4	150078444	150257438	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6350
enhrx-128945	chr4	153877991	153878021	152956839	152956869	4550	hg19	N/A	enh45762	N/A	Enhatls137866	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.19222		-0.52376			FHDC1	chr4	152936322	152979671	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6489
enhrx-128974	chr4	154350532	154350557	153429380	153429405	4551	hg19	N/A	enh8285	N/A	Enhatls137895	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.98112		-0.67909			MND1	chr4	153344648	153415118	11687	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6518
enhrx-128974	chr4	154350586	154350611	153429434	153429459	4552	hg19	N/A	enh8285	N/A	Enhatls137895	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.192917		0.33965			MND1	chr4	153344648	153415118	11687	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6518
enhrx-129160	chr4	157863525	157863552	156942373	156942400	4553	hg19	N/A	enh21899	N/A	Enhatls138085	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.36544		-0.75476			PDGFC	chr4	156760453	156971799	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6704
enhrx-129187	chr4	158939886	158939911	158018734	158018759	4554	hg19	N/A	enh37266	N/A	Enhatls138113	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67771		-0.61935			GASK1B	chr4	158124473	158173318	103644	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6731
enhrx-129886	chr4	184286091	184286114	183364938	183364961	4555	hg19	N/A	enh21980	N/A	Enhatls138844	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.35567		-0.94973			CLDN24	chr4	183321763	183322426	27591	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7430
enhrx-129886	chr4	184328611	184328638	183407458	183407485	4556	hg19	N/A	enh21982	fant17532	Enhatls138844	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.77223		-0.63796			CDKN2AIP	chr4	183444634	183449064	37044	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7430
enhrx-129886	chr4	184328715	184328737	183407562	183407584	4557	hg19	N/A	enh21982	fant17532	Enhatls138844	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.52916		-0.5901			CDKN2AIP	chr4	183444634	183449064	37044	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7430
enhrx-130157	chr4	187858236	187858262	186937082	186937108	4558	hg19	N/A	enh8350	N/A	Enhatls139142	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.62682		-0.60933			FAT1	chr4	186587793	186726722	184430	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7701
enhrx-130157	chr4	187864537	187864573	186943383	186943419	4559	hg19	N/A	enh8350	N/A	Enhatls139142	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01604		-0.48907			FAT1	chr4	186587793	186726722	184430	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7701
enhrx-130157	chr4	187864632	187864666	186943478	186943512	4560	hg19	N/A	enh8350	N/A	Enhatls139142	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.063813		0.31423			FAT1	chr4	186587793	186726722	184430	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7701
enhrx-lit68	chr5	536259	536281	536144	536166	4561	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01802		-0.48946								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-lit69	chr5	536326	536366	536211	536251	4562	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56532		-0.59722								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-130571	chr5	7245664	7245699	7245551	7245586	4563	hg19	N/A	enh55159	N/A	Enhatls139579	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05672		-0.49708			ADCY2	chr5	7396137	7830081	148916	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	362
enhrx-130648	chr5	9357168	9357198	9357056	9357086	4564	hg19	N/A	N/A	N/A	Enhatls139658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76006		-0.43867			SEMA5A	chr5	9035032	9546075	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	439
enhrx-130648	chr5	9357265	9357295	9357153	9357183	4565	hg19	N/A	N/A	N/A	Enhatls139658	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.45918		0.58897			SEMA5A	chr5	9035032	9546075	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	439
enhrx-130975	chr5	17190562	17190588	17190453	17190479	4566	hg19	N/A	enh22080	N/A	Enhatls139999	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9345		-0.66991			BASP1	chr5	17065597	17276843	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	766
enhrx-132244	chr5	55995432	55995460	56699605	56699633	4567	hg19	N/A	enh8460	N/A	Enhatls141333	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.4661		-0.77458			MAP3K1	chr5	56815548	56896152	109361	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2035
enhrx-132334	chr5	58484453	58484478	59188627	59188652	4568	hg19	N/A	enh55262	N/A	Enhatls141430	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.81667		-0.64671			PDE4D	chr5	58969037	60488076	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2125
enhrx-132339	chr5	58955379	58955414	59659553	59659588	4569	hg19	N/A	enh63411	N/A	Enhatls141435	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22209		-0.52964			PDE4D	chr5	58969037	60488076	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2130
enhrx-132397	chr5	60699425	60699452	61403598	61403625	4570	hg19	N/A	enh22276	N/A	Enhatls141491	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57695		-0.59951			ZSWIM6	chr5	61332257	61546172	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2188
enhrx-132397	chr5	60704566	60704594	61408739	61408767	4571	hg19	hs3003	enh22276	N/A	Enhatls141491	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.59787		-0.60363			ZSWIM6	chr5	61332257	61546172	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2188
enhrx-132667	chr5	67069425	67069455	67773597	67773627	4572	hg19	N/A	enh22308	fant18793	Enhatls141777	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73462		-0.43366			PIK3R1	chr5	68215740	68301821	441814	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2458
enhrx-132667	chr5	67069521	67069551	67773693	67773723	4573	hg19	N/A	enh22308	fant18793	Enhatls141777	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-5.25346		-1.1265			PIK3R1	chr5	68215740	68301821	441814	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2458
enhrx-132980	chr5	71907116	71907138	72611289	72611311	4574	hg19	N/A	enh22338	N/A	Enhatls142096	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.94725		-0.67242			ZNF366	chr5	72439902	72507410	91173	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2771
enhrx-133087	chr5	73553631	73553658	74257806	74257833	4575	hg19	N/A	enh22352	N/A	Enhatls142204	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.33294		-0.74836			ARHGEF28	chr5	73626157	73941993	313068	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2878
enhrx-133091	chr5	73711912	73711939	74416087	74416114	4576	hg19	N/A	enh37978	N/A	Enhatls142210	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05997		-0.49772			ENC1	chr5	74627405	74641424	206416	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2882
enhrx-133091	chr5	73795841	73795870	74500016	74500045	4577	hg19	N/A	enh57904	N/A	Enhatls142210	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.891464		0.47719			ENC1	chr5	74627405	74641424	124941	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2882
enhrx-133091	chr5	73883380	73883409	74587555	74587584	4578	hg19	N/A	enh37981	N/A	Enhatls142210	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.85974		-0.65519			ENC1	chr5	74627405	74641424	26056	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2882
enhrx-133400	chr5	78203236	78203262	78907413	78907439	4579	hg19	N/A	enh22385	fant19015	Enhatls142521	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5254		-0.58936			ARSB	chr5	78777208	78986087	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3191
enhrx-133666	chr5	81609115	81609144	82313296	82313325	4580	hg19	N/A	N/A	N/A	Enhatls142795	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20914		-0.52709			RPS23	chr5	82273319	82278396	34456	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3457
enhrx-133808	chr5	88716508	88716535	89420691	89420718	4581	hg19	N/A	enh38076	N/A	Enhatls142949	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03407		-0.49262			MEF2C	chr5	88717116	88904257	514792	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3599
enhrx-134208	chr5	97846592	97846621	98510888	98510917	4582	hg19	N/A	enh55399	N/A	Enhatls143377	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.331418		0.36692			RGMB	chr5	98769294	98796494	249324	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3999
enhrx-134208	chr5	97846685	97846714	98510981	98511010	4583	hg19	N/A	enh55399	N/A	Enhatls143377	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.87183		-0.65757			RGMB	chr5	98769294	98796494	249324	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3999
enhrx-134245	chr5	98356061	98356091	99020357	99020387	4584	hg19	N/A	enh38171	N/A	Enhatls143413	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1293		-0.51137			CHD1	chr5	98853984	98929007	87415	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4036
enhrx-134301	chr5	102107311	102107341	102771607	102771637	4585	hg19	N/A	enh66046	N/A	Enhatls143471	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.32608		-0.74701			PAM	chr5	102753980	103029730	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4092
enhrx-134391	chr5	106808822	106808847	107473121	107473146	4586	hg19	N/A	enh22477	N/A	Enhatls143560	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36303		-0.55739			EFNA5	chr5	107376893	107670937	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4182
enhrx-134391	chr5	106812230	106812255	107476529	107476554	4587	hg19	N/A	enh22477	N/A	Enhatls143560	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-6.08385		-1.29			EFNA5	chr5	107376893	107670937	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4182
enhrx-134391	chr5	106814152	106814180	107478451	107478479	4588	hg19	hs1733	enh22477	N/A	Enhatls143560	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.14693		-0.90863			EFNA5	chr5	107376893	107670937	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4182
enhrx-134687	chr5	115192734	115192761	115857037	115857064	4589	hg19	N/A	enh22512	N/A	Enhatls143874	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.61613		-0.80412			AP3S1	chr5	115841934	115914081	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4478
enhrx-134851	chr5	119128217	119128240	119792522	119792545	4590	hg19	N/A	enh45948	N/A	Enhatls144048	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01228		-0.48833			FAM170A	chr5	119629557	119635822	151729	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4642
enhrx-134881	chr5	121668972	121669000	122333277	122333305	4591	hg19	N/A	enh55445	N/A	Enhatls144077	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.836838		0.26954			SNCAIP	chr5	122311353	122464219	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4672
enhrx-134970	chr5	123970133	123970162	124634440	124634469	4592	hg19	N/A	enh38340	N/A	Enhatls144176	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.66839		-0.42062			ZNF608	chr5	124636914	124748807	13	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4761
enhrx-134970	chr5	123970321	123970349	124634628	124634656	4593	hg19	N/A	enh38340	N/A	Enhatls144176	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67266		-0.42146			ZNF608	chr5	124636914	124748807	13	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4761
enhrx-134970	chr5	123970380	123970408	124634687	124634715	4594	hg19	N/A	enh38340	N/A	Enhatls144176	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72043		-0.62776			ZNF608	chr5	124636914	124748807	13	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4761
enhrx-134970	chr5	123970528	123970555	124634835	124634862	4595	hg19	N/A	enh38340	N/A	Enhatls144176	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.60773		-0.99936			ZNF608	chr5	124636914	124748807	13	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4761
enhrx-134977	chr5	124218370	124218407	124882677	124882714	4596	hg19	N/A	enh55456	N/A	Enhatls144185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92533		-0.47121			ZNF608	chr5	124636914	124748807	132986	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4768
enhrx-134977	chr5	124224965	124224994	124889272	124889301	4597	hg19	N/A	enh55456	N/A	Enhatls144185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.612		-1.0002			ZNF608	chr5	124636914	124748807	132986	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4768
enhrx-134977	chr5	124225088	124225117	124889395	124889424	4598	hg19	N/A	enh55456	N/A	Enhatls144185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.73036		-0.82661			ZNF608	chr5	124636914	124748807	132986	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4768
enhrx-134977	chr5	124225262	124225288	124889569	124889595	4599	hg19	N/A	enh55456	N/A	Enhatls144185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.92886		-0.6688			ZNF608	chr5	124636914	124748807	132986	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4768
enhrx-134977	chr5	124225318	124225345	124889625	124889652	4600	hg19	N/A	enh55456	N/A	Enhatls144185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.60803		-0.60563			ZNF608	chr5	124636914	124748807	132986	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4768
enhrx-134982	chr5	125004823	125004849	125669130	125669156	4601	hg19	N/A	enh55465	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.62187		-0.80525			GRAMD2B	chr5	126360131	126494371	688792	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-134982	chr5	125032359	125032387	125696666	125696694	4602	hg19	N/A	enh38357	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.113433		0.324			GRAMD2B	chr5	126360131	126494371	657390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-134982	chr5	125035907	125035938	125700214	125700245	4603	hg19	N/A	enh38357	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.90507		-0.46722			GRAMD2B	chr5	126360131	126494371	657390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-134982	chr5	125036080	125036106	125700387	125700413	4604	hg19	N/A	enh38357	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49965		-0.58429			GRAMD2B	chr5	126360131	126494371	657390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-134982	chr5	125036136	125036162	125700443	125700469	4605	hg19	N/A	enh38357	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75562		-0.63469			GRAMD2B	chr5	126360131	126494371	657390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-134982	chr5	125036467	125036494	125700774	125700801	4606	hg19	N/A	enh38357	N/A	Enhatls144195	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.74777		-0.43625			GRAMD2B	chr5	126360131	126494371	657390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4773
enhrx-135082	chr5	127149403	127149428	127813711	127813736	4607	hg19	N/A	enh8654	N/A	Enhatls144302	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.130803		0.32742			CCDC192	chr5	127703360	127941507	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4873
enhrx-135082	chr5	127149875	127149903	127814183	127814211	4608	hg19	N/A	enh8654	N/A	Enhatls144302	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.60356		-0.60475			CCDC192	chr5	127703360	127941507	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4873
enhrx-135861	chr5	138441062	138441089	139105373	139105400	4609	hg19	N/A	enh38443	N/A	Enhatls145139	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5447		-0.59316			SIL1	chr5	138946723	139198368	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5652
enhrx-135861	chr5	138441241	138441269	139105552	139105580	4610	hg19	N/A	enh38443	N/A	Enhatls145139	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98038		-0.48205			SIL1	chr5	138946723	139198368	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5652
enhrx-135861	chr5	138441360	138441388	139105671	139105699	4611	hg19	N/A	enh38443	N/A	Enhatls145139	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9039		-0.46699			SIL1	chr5	138946723	139198368	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5652
enhrx-135960	chr5	139641048	139641076	140261463	140261491	4612	hg19	N/A	enh22635	N/A	Enhatls145249	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.278141		0.35643			PFDN1	chr5	140245034	140303113	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5751
enhrx-135963	chr5	139691772	139691799	140312187	140312214	4613	hg19	N/A	enh38452	fant20036	Enhatls145252	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03016		-0.49185			PFDN1	chr5	140245034	140303113	8890	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5754
enhrx-136167	chr5	141536786	141536807	142157221	142157242	4614	hg19	N/A	enh22644	N/A	Enhatls145467	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16145		-0.5177			NDFIP1	chr5	142108778	142154440	530	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5958
enhrx-136167	chr5	141536943	141536969	142157378	142157404	4615	hg19	N/A	enh22644	N/A	Enhatls145467	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.83043		-0.64942			NDFIP1	chr5	142108778	142154440	530	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5958
enhrx-136167	chr5	141538304	141538329	142158739	142158764	4616	hg19	N/A	enh22644	N/A	Enhatls145467	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01771		-0.4894			NDFIP1	chr5	142108778	142154440	530	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5958
enhrx-136167	chr5	141566268	141566296	142186703	142186731	4617	hg19	N/A	enh55506	N/A	Enhatls145467	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.173211		0.33577			NDFIP1	chr5	142108778	142154440	24641	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5958
enhrx-136171	chr5	141770187	141770214	142390622	142390649	4618	hg19	N/A	enh22651	N/A	Enhatls145472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.86235		-0.45881			SPRY4	chr5	142310426	142325021	65418	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5962
enhrx-136171	chr5	141770345	141770381	142390780	142390816	4619	hg19	N/A	enh22651	N/A	Enhatls145472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.10033		-0.70256			SPRY4	chr5	142310426	142325021	65418	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5962
enhrx-136171	chr5	141800180	141800208	142420615	142420643	4620	hg19	N/A	enh8742	N/A	Enhatls145472	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.645117		0.62558			SPRY4	chr5	142310426	142325021	92320	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5962
enhrx-136171	chr5	141801146	141801174	142421581	142421609	4621	hg19	N/A	enh8742	N/A	Enhatls145472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98105		-0.48218			SPRY4	chr5	142310426	142325021	92320	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5962
enhrx-136171	chr5	141806014	141806042	142426449	142426477	4622	hg19	N/A	enh8742	fant20109	Enhatls145472	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.22273		-0.72666			SPRY4	chr5	142310426	142325021	101410	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5962
enhrx-136172	chr5	141846464	141846491	142466899	142466926	4623	hg19	N/A	enh38458	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.250258		0.35094			FGF1	chr5	142592177	142698070	123308	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136172	chr5	141846493	141846520	142466928	142466955	4624	hg19	N/A	enh38458	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16607		-0.51861			FGF1	chr5	142592177	142698070	123308	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136172	chr5	141870745	141870773	142491180	142491208	4625	hg19	N/A	enh22655	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.339268		0.56536			FGF1	chr5	142592177	142698070	96845	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136172	chr5	141879400	141879428	142499835	142499863	4626	hg19	N/A	enh72028	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98709		-0.48337			FGF1	chr5	142592177	142698070	89628	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136172	chr5	141890917	141890943	142511352	142511378	4627	hg19	N/A	enh22656	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.88463		0.27895			FGF1	chr5	142592177	142698070	75608	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136172	chr5	141891134	141891162	142511569	142511597	4628	hg19	N/A	enh22656	N/A	Enhatls145473	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25586		-0.53629			FGF1	chr5	142592177	142698070	75608	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5963
enhrx-136179	chr5	142092573	142092602	142713008	142713037	4629	hg19	N/A	enh22663	N/A	Enhatls145480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.39881		-0.76133			FGF1	chr5	142592177	142698070	13232	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5970
enhrx-136939	chr5	154033645	154033671	154654085	154654111	4630	hg19	N/A	enh55548	N/A	Enhatls146334	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15632		-0.51669			LARP1	chr5	154682985	154817605	25774	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6730
enhrx-lit70	chr5	159744225	159744246	160317218	160317239	4631	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00309		-0.48652								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-137318	chr5	163618164	163618188	164191158	164191182	4632	hg19	N/A	enh38604	N/A	Enhatls146744	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.82266		-0.64789			MAT2B	chr5	163503113	163519558	662735	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7109
enhrx-137318	chr5	163618616	163618638	164191610	164191632	4633	hg19	N/A	enh38604	N/A	Enhatls146744	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15886		-0.51719			MAT2B	chr5	163503113	163519558	662735	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7109
enhrx-137581	chr5	171094885	171094914	171667881	171667910	4634	hg19	N/A	enh38662	fant20795	Enhatls147031	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84041		-0.45449			SMIM23	chr5	171785816	171791136	117735	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7372
enhrx-138456	chr6	600135	600162	600135	600162	4635	hg19	N/A	N/A	N/A	Enhatls148013	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1101		-0.50759			EXOC2	chr6	485153	693139	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	44
enhrx-138594	chr6	3997510	3997544	3997276	3997310	4636	hg19	N/A	enh38745	fant21279	Enhatls148165	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6093		-0.60588			PRP4K	chr6	4021299	4064983	23862	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	182
enhrx-138797	chr6	9457024	9457053	9456791	9456820	4637	hg19	N/A	enh72161	N/A	Enhatls148384	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09105		-0.50384			TFAP2A	chr6	10393185	10419638	934540	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	385
enhrx-138896	chr6	11263706	11263734	11263473	11263501	4638	hg19	N/A	enh23019	fant21480	Enhatls148492	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83874		-0.45416			NEDD9	chr6	11183297	11382348	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	484
enhrx-138896	chr6	11263893	11263919	11263660	11263686	4639	hg19	N/A	enh23019	fant21480	Enhatls148492	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.165977		0.53124			NEDD9	chr6	11183297	11382348	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	484
enhrx-138896	chr6	11263956	11263987	11263723	11263754	4640	hg19	N/A	enh23019	fant21480	Enhatls148492	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.28375		-0.54178			NEDD9	chr6	11183297	11382348	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	484
enhrx-138927	chr6	12537711	12537738	12537479	12537506	4641	hg19	N/A	enh23037	N/A	Enhatls148526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98755		-0.48346			PHACTR1	chr6	12716553	13290446	170575	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	515
enhrx-139005	chr6	14211407	14211432	14211176	14211201	4642	hg19	N/A	enh55650	fant21654	Enhatls148606	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.80672		-0.64475			CD83	chr6	14117255	14136918	73913	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	593
enhrx-139008	chr6	15304844	15304869	15304613	15304638	4643	hg19	N/A	enh38820	N/A	Enhatls148612	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.838362		0.26984			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	596
enhrx-139008	chr6	15319071	15319098	15318840	15318867	4644	hg19	N/A	enh38820	N/A	Enhatls148612	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.94265		-0.47462			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	596
enhrx-139008	chr6	15320962	15320990	15320731	15320759	4645	hg19	N/A	enh38820	N/A	Enhatls148612	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.42306		-0.56921			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	596
enhrx-139009	chr6	15400266	15400296	15400035	15400065	4646	hg19	N/A	enh46082	fant21756	Enhatls148613	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.126		-0.51072			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	597
enhrx-139009	chr6	15404865	15404894	15404634	15404663	4647	hg19	N/A	enh46082	N/A	Enhatls148613	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.85001		-0.45638			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	597
enhrx-139010	chr6	15433491	15433519	15433260	15433288	4648	hg19	N/A	enh38822	N/A	Enhatls148614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.08031		-0.69862			JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	598
enhrx-139196	chr6	20292112	20292141	20291881	20291910	4649	hg19	N/A	enh55676	N/A	Enhatls148811	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01416		-0.4887			MBOAT1	chr6	20099683	20212469	77306	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	784
enhrx-139196	chr6	20292143	20292172	20291912	20291941	4650	hg19	N/A	enh55676	N/A	Enhatls148811	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.98483		-0.67982			MBOAT1	chr6	20099683	20212469	77306	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	784
enhrx-139211	chr6	20876249	20876278	20876018	20876047	4651	hg19	N/A	enh23104	N/A	Enhatls148826	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.774447		0.45415			CDKAL1	chr6	20534456	21232404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	799
enhrx-139222	chr6	21843651	21843677	21843420	21843446	4652	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.84567		-0.65242			SOX4	chr6	21593750	21598619	223580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21845348	21845376	21845117	21845145	4653	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.50209		-0.58477			SOX4	chr6	21593750	21598619	223580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21845378	21845406	21845147	21845175	4654	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40544		-0.56574			SOX4	chr6	21593750	21598619	223580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21847154	21847184	21846923	21846953	4655	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9362		-0.47335			SOX4	chr6	21593750	21598619	247035	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21847281	21847311	21847050	21847080	4656	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95438		-0.47693			SOX4	chr6	21593750	21598619	247035	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21848096	21848125	21847865	21847894	4657	hg19	N/A	enh38893	N/A	Enhatls148842	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.0934		-0.89809			SOX4	chr6	21593750	21598619	247035	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21943497	21943526	21943266	21943295	4658	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.75123		-0.43693			PRL	chr6	22287243	22302826	340840	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21948608	21948635	21948377	21948404	4659	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.18819		-0.71986			PRL	chr6	22287243	22302826	330220	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21948667	21948695	21948436	21948464	4660	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.99849		-0.68251			PRL	chr6	22287243	22302826	330220	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21949880	21949906	21949649	21949675	4661	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.949363		0.48859			PRL	chr6	22287243	22302826	330220	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21954402	21954425	21954171	21954194	4662	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.65991		-0.81274			PRL	chr6	22287243	22302826	330220	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139222	chr6	21954661	21954695	21954430	21954464	4663	hg19	N/A	enh23123	N/A	Enhatls148843	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.19812		-0.52492			PRL	chr6	22287243	22302826	330220	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	810
enhrx-139223	chr6	21987746	21987775	21987517	21987546	4664	hg19	N/A	enh23124	fant21952	Enhatls148844	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.896769		0.28134			PRL	chr6	22287243	22302826	299514	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-139223	chr6	21987809	21987839	21987580	21987610	4665	hg19	N/A	enh23124	fant21952	Enhatls148844	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.61575		-0.60715			PRL	chr6	22287243	22302826	299514	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-139223	chr6	21987891	21987920	21987662	21987691	4666	hg19	N/A	enh23124	fant21952	Enhatls148844	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.88729		-0.46372			PRL	chr6	22287243	22302826	299514	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-139236	chr6	22828412	22828439	22828183	22828210	4667	hg19	N/A	enh23125	N/A	Enhatls148860	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.24421		-0.73089			HDGFL1	chr6	22569565	22571666	253391	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	824
enhrx-139236	chr6	22828777	22828806	22828548	22828577	4668	hg19	N/A	enh23125	N/A	Enhatls148860	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.41646		-0.56791			HDGFL1	chr6	22569565	22571666	253391	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	824
enhrx-140431	chr6	33601805	33601825	33634028	33634048	4669	hg19	N/A	enh49080	fant22286	Enhatls150125	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03199		-0.49221			ITPR3	chr6	33620364	33696574	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2019
enhrx-140431	chr6	33602928	33602960	33635151	33635183	4670	hg19	N/A	enh49080	N/A	Enhatls150125	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.512813		0.59953			ITPR3	chr6	33620364	33696574	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2019
enhrx-140431	chr6	33602995	33603018	33635218	33635241	4671	hg19	N/A	enh49080	N/A	Enhatls150125	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.74234		-0.43518			ITPR3	chr6	33620364	33696574	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2019
enhrx-140634	chr6	35316247	35316274	35348470	35348497	4672	hg19	N/A	N/A	N/A	Enhatls150342	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.41562		-0.76464			PPARD	chr6	35342557	35428191	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2222
enhrx-140881	chr6	37099137	37099165	37131361	37131389	4673	hg19	N/A	enh23203	fant22452	Enhatls150614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26394		-0.53788			PIM1	chr6	37170151	37175428	38517	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2469
enhrx-140881	chr6	37102639	37102667	37134863	37134891	4674	hg19	N/A	enh23203	fant22453	Enhatls150614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.0327		-0.88614			PIM1	chr6	37170151	37175428	35153	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2469
enhrx-140881	chr6	37105406	37105437	37137630	37137661	4675	hg19	N/A	enh23203	N/A	Enhatls150614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00304		-0.48651			PIM1	chr6	37170151	37175428	28671	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2469
enhrx-140881	chr6	37109397	37109426	37141621	37141650	4676	hg19	N/A	enh23203	fant22456	Enhatls150614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-6.21032		-1.3149			PIM1	chr6	37170151	37175428	28206	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2469
enhrx-141583	chr6	43894356	43894383	43926619	43926646	4677	hg19	N/A	enh23256	N/A	Enhatls151363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.35322		-0.55546			VEGFA	chr6	43770210	43786487	128482	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-141583	chr6	43900883	43900921	43933146	43933184	4678	hg19	N/A	enh91691	N/A	Enhatls151363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68383		-0.42366			VEGFA	chr6	43770210	43786487	144982	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-141583	chr6	43900930	43900953	43933193	43933216	4679	hg19	N/A	enh91691	N/A	Enhatls151363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.87129		-0.46057			VEGFA	chr6	43770210	43786487	144982	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-142068	chr6	52454051	52454078	52589253	52589280	4680	hg19	N/A	enh9158	N/A	Enhatls151884	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09918		-0.50544			TRAM2	chr6	52497407	52577060	6933	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3656
enhrx-142119	chr6	52913917	52913958	53049119	53049160	4681	hg19	N/A	N/A	N/A	Enhatls151938	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20548		-0.52637			CILK1	chr6	53001278	53061824	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3707
enhrx-142119	chr6	52913917	52913958	53049119	53049160	4682	hg19	N/A	N/A	N/A	Enhatls151938	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20548		-0.52637			FBXO9	chr6	53051990	53100873	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3707
enhrx-142462	chr6	64658187	64658216	63948294	63948323	4683	hg19	N/A	N/A	N/A	Enhatls152308	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92137		-0.47043			EYS	chr6	63719979	65707226	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4050
enhrx-142681	chr6	72113216	72113245	71403513	71403542	4684	hg19	N/A	enh23343	N/A	Enhatls152526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76301		-0.43925			OGFRL1	chr6	71288810	71309059	92424	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142681	chr6	72114405	72114432	71404702	71404729	4685	hg19	N/A	enh23343	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.6492		-0.81063			OGFRL1	chr6	71288810	71309059	94489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142681	chr6	72114462	72114489	71404759	71404786	4686	hg19	N/A	enh23343	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.49661		-0.97748			OGFRL1	chr6	71288810	71309059	94489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142681	chr6	72114578	72114605	71404875	71404902	4687	hg19	N/A	enh23343	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.6077		-0.80246			OGFRL1	chr6	71288810	71309059	94489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142681	chr6	72114615	72114643	71404912	71404940	4688	hg19	N/A	enh23343	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.99001		-0.68084			OGFRL1	chr6	71288810	71309059	94489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142681	chr6	72117392	72117427	71407689	71407724	4689	hg19	N/A	enh23343	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.65836		-0.61554			OGFRL1	chr6	71288810	71309059	94489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4269
enhrx-142687	chr6	72205889	72205930	71496186	71496227	4690	hg19	N/A	enh39132	N/A	Enhatls152533	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.223645		0.3457			OGFRL1	chr6	71288810	71309059	184544	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4275
enhrx-142687	chr6	72206003	72206031	71496300	71496328	4691	hg19	N/A	enh39132	N/A	Enhatls152533	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.83722		-0.84765			OGFRL1	chr6	71288810	71309059	184544	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4275
enhrx-142787	chr6	74290177	74290218	73580454	73580495	4692	hg19	N/A	enh9211	fant23111	Enhatls152640	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.00152		-0.88			SLC17A5	chr6	73593378	73653992	12535	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4375
enhrx-143032	chr6	79924284	79924310	79214567	79214593	4693	hg19	N/A	N/A	N/A	Enhatls152893	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.8896		-0.66107			HMGN3	chr6	79201244	79234689	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4620
enhrx-143093	chr6	82854137	82854164	82144420	82144447	4694	hg19	N/A	enh39204	N/A	Enhatls152954	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.374		-0.55955			IBTK	chr6	82169986	82247754	22693	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4681
enhrx-143093	chr6	82854471	82854499	82144754	82144782	4695	hg19	N/A	enh39204	N/A	Enhatls152954	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1651		-0.51842			IBTK	chr6	82169986	82247754	22693	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4681
enhrx-143123	chr6	83618965	83618992	82909246	82909273	4696	hg19	N/A	enh55865	N/A	Enhatls152984	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.06686		-0.69597			UBE3D	chr6	82892389	83065841	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4711
enhrx-143123	chr6	83619171	83619198	82909452	82909479	4697	hg19	N/A	enh55865	N/A	Enhatls152984	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76128		-0.43891			UBE3D	chr6	82892389	83065841	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4711
enhrx-143406	chr6	88508886	88508913	87799168	87799195	4698	hg19	N/A	enh23404	N/A	Enhatls153279	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66095		-0.61605			AKIRIN2	chr6	87674859	87702233	87708	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4994
enhrx-143738	chr6	98298601	98298629	97850725	97850753	4699	hg19	N/A	enh72396	N/A	Enhatls153618	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.45272		-0.57505			MMS22L	chr6	97142160	97283216	564780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5326
enhrx-143738	chr6	98298806	98298834	97850930	97850958	4700	hg19	N/A	enh72396	N/A	Enhatls153618	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69698		-0.42625			MMS22L	chr6	97142160	97283216	564780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5326
enhrx-143738	chr6	98298836	98298863	97850960	97850987	4701	hg19	N/A	enh72396	N/A	Enhatls153618	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71085		-0.42898			MMS22L	chr6	97142160	97283216	564780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5326
enhrx-143738	chr6	98298865	98298892	97850989	97851016	4702	hg19	N/A	enh72396	N/A	Enhatls153618	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.68432		-0.62065			MMS22L	chr6	97142160	97283216	564780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5326
enhrx-143956	chr6	105936007	105936034	105488132	105488159	4703	hg19	N/A	enh39304	N/A	Enhatls153832	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.197009		0.53735			PREP	chr6	105273217	105454062	26229	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5544
enhrx-143956	chr6	105936420	105936447	105488545	105488572	4704	hg19	N/A	enh39304	N/A	Enhatls153832	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6091		-0.60584			PREP	chr6	105273217	105454062	26229	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5544
enhrx-143956	chr6	106035748	106035777	105587873	105587902	4705	hg19	N/A	enh23450	N/A	Enhatls153832	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.59676		-0.9972			PREP	chr6	105273217	105454062	131191	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5544
enhrx-144023	chr6	107856101	107856129	107534897	107534925	4706	hg19	N/A	enh9293	N/A	Enhatls153910	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.34185		-0.94701			SOBP	chr6	107490116	107661306	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5611
enhrx-144023	chr6	107857327	107857355	107536123	107536151	4707	hg19	N/A	enh9293	N/A	Enhatls153910	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.09004		-0.89743			SOBP	chr6	107490116	107661306	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5611
enhrx-144023	chr6	107859495	107859521	107538291	107538317	4708	hg19	N/A	enh9293	N/A	Enhatls153910	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.42042		-0.56869			SOBP	chr6	107490116	107661306	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5611
enhrx-144026	chr6	107992242	107992273	107671038	107671069	4709	hg19	N/A	enh9300	N/A	Enhatls153913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.47948		-0.58032			SOBP	chr6	107490116	107661306	2076	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5614
enhrx-144026	chr6	107992275	107992306	107671071	107671102	4710	hg19	N/A	enh9300	N/A	Enhatls153913	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.87922		-0.85592			SOBP	chr6	107490116	107661306	2076	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5614
enhrx-144055	chr6	108324259	108324288	108003055	108003084	4711	hg19	N/A	enh23476	fant23608	Enhatls153942	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73876		-0.63137			OSTM1	chr6	108041408	108165840	38142	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5643
enhrx-144090	chr6	109065876	109065904	108744673	108744701	4712	hg19	N/A	enh23481	N/A	Enhatls153977	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.141192		0.52636			FOXO3	chr6	108559834	108684774	57599	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5678
enhrx-144339	chr6	111851913	111851941	111530710	111530738	4713	hg19	N/A	enh49144	N/A	Enhatls154258	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.234564		0.34785			TRAF3IP2	chr6	111555380	111606906	11768	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5927
enhrx-144339	chr6	111860551	111860579	111539348	111539376	4714	hg19	N/A	enh49144	N/A	Enhatls154258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.002		-0.6832			TRAF3IP2	chr6	111555380	111606906	11768	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5927
enhrx-144339	chr6	111864066	111864094	111542863	111542891	4715	hg19	N/A	enh49144	N/A	Enhatls154258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95392		-0.47684			TRAF3IP2	chr6	111555380	111606906	11768	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5927
enhrx-144357	chr6	112364423	112364459	112043220	112043256	4716	hg19	N/A	enh9329	fant23740	Enhatls154284	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.33812		-0.74938			CCN6	chr6	112054074	112069686	10792	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5945
enhrx-144357	chr6	112364896	112364927	112043693	112043724	4717	hg19	N/A	enh9329	N/A	Enhatls154284	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.71393		-0.62648			CCN6	chr6	112054074	112069686	6563	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5945
enhrx-144357	chr6	112364929	112364960	112043726	112043757	4718	hg19	N/A	enh9329	N/A	Enhatls154284	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.3242		-0.74664			CCN6	chr6	112054074	112069686	6563	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5945
enhrx-144416	chr6	114151093	114151114	113829890	113829911	4719	hg19	N/A	N/A	N/A	Enhatls154346	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.78544		-0.64056			MARCKS	chr6	113857344	113863475	22049	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6004
enhrx-144624	chr6	118456658	118456697	118135495	118135534	4720	hg19	N/A	enh55962	N/A	Enhatls154563	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57273		-0.59868			SLC35F1	chr6	117907263	118317676	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6212
enhrx-144624	chr6	118456724	118456751	118135561	118135588	4721	hg19	N/A	enh55962	N/A	Enhatls154563	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.43573		-0.7686			SLC35F1	chr6	117907263	118317676	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6212
enhrx-144911	chr6	126855808	126855838	126534662	126534692	4722	hg19	N/A	enh55981	N/A	Enhatls154860	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.75529		-0.43773			CENPW	chr6	126340114	126348875	178905	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6499
enhrx-145125	chr6	131266797	131266827	130945657	130945687	4723	hg19	N/A	enh39489	N/A	Enhatls155080	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.72857		-0.43247			EPB41L2	chr6	130839346	131063322	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6713
enhrx-145125	chr6	131266895	131266926	130945755	130945786	4724	hg19	N/A	enh39489	N/A	Enhatls155080	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.04738		-0.49524			EPB41L2	chr6	130839346	131063322	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6713
enhrx-145226	chr6	132383040	132383065	132061900	132061925	4725	hg19	N/A	enh39498	N/A	Enhatls155185	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.720256		0.44348			CCN2	chr6	131948175	131951372	109781	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6814
enhrx-145622	chr6	139717420	139717448	139396283	139396311	4726	hg19	N/A	enh9396	N/A	Enhatls155653	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.28908		-0.54283			CITED2	chr6	139371806	139374648	16297	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7210
enhrx-145623	chr6	140076606	140076633	139755469	139755496	4727	hg19	N/A	enh23693	N/A	Enhatls155657	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.391145		0.37868			CITED2	chr6	139371806	139374648	374306	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7211
enhrx-145624	chr6	140193417	140193444	139872280	139872307	4728	hg19	N/A	enh56025	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.76524		-0.43969			CITED2	chr6	139371806	139374648	494481	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140226977	140227005	139905840	139905868	4729	hg19	N/A	enh56026	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5836		-0.60082			CITED2	chr6	139371806	139374648	526909	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140247566	140247595	139926429	139926458	4730	hg19	N/A	enh39566	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.93		-0.47213			CITED2	chr6	139371806	139374648	549256	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140247690	140247720	139926553	139926583	4731	hg19	N/A	enh39566	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2228		-0.52978			CITED2	chr6	139371806	139374648	549256	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140259234	140259261	139938097	139938124	4732	hg19	N/A	enh23697	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26566		-0.53822			CITED2	chr6	139371806	139374648	562649	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140259466	140259493	139938329	139938356	4733	hg19	N/A	enh23697	N/A	Enhatls155660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72474		-0.62861			CITED2	chr6	139371806	139374648	562649	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140371572	140371600	140050435	140050463	4734	hg19	N/A	enh23700	fant24409	Enhatls155664	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.738		-0.63122			CITED2	chr6	139371806	139374648	675599	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140373358	140373387	140052221	140052250	4735	hg19	N/A	enh23700	N/A	Enhatls155664	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.862		-0.45874			CITED2	chr6	139371806	139374648	675969	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145624	chr6	140385767	140385789	140064630	140064652	4736	hg19	N/A	enh23701	N/A	Enhatls155664	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.27445		-0.53995			CITED2	chr6	139371806	139374648	687707	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7212
enhrx-145628	chr6	140701197	140701227	140380060	140380090	4737	hg19	N/A	enh56030	N/A	Enhatls155669	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49355		-0.58309			CITED2	chr6	139371806	139374648	1003401	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7216
enhrx-146103	chr6	151579329	151579357	151258194	151258222	4738	hg19	N/A	enh23786	N/A	Enhatls156172	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79267		-0.44509			AKAP12	chr6	151239966	151358559	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7691
enhrx-147560	chr7	4690666	4690696	4651035	4651065	4739	hg19	N/A	enh56149	N/A	Enhatls157694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05063		-0.49588			FOXK1	chr7	4682294	4771442	28731	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	372
enhrx-148092	chr7	12755468	12755495	12715843	12715870	4740	hg19	N/A	enh23992	fant25599	Enhatls158259	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.70567		-0.42796			ARL4A	chr7	12686855	12690958	24691	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	904
enhrx-148092	chr7	12769072	12769113	12729447	12729488	4741	hg19	N/A	enh59719	N/A	Enhatls158259	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67992		-0.42289			ARL4A	chr7	12686855	12690958	34683	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	904
enhrx-148092	chr7	13057228	13057253	13017603	13017628	4742	hg19	N/A	enh39882	fant25604	Enhatls158259	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.90639		-0.86127			ARL4A	chr7	12686855	12690958	326519	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	904
enhrx-148162	chr7	16533536	16533563	16493911	16493938	4743	hg19	N/A	enh39913	N/A	Enhatls158334	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.35986		-0.75366			CRPPA	chr7	16087524	16502504	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	974
enhrx-148162	chr7	16533536	16533563	16493911	16493938	4744	hg19	N/A	enh39913	N/A	Enhatls158334	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.35986		-0.75366			SOSTDC1	chr7	16461480	16530580	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	974
enhrx-148162	chr7	16534269	16534295	16494644	16494670	4745	hg19	N/A	enh39913	N/A	Enhatls158334	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75552		-0.63467			CRPPA	chr7	16087524	16502504	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	974
enhrx-148162	chr7	16534269	16534295	16494644	16494670	4746	hg19	N/A	enh39913	N/A	Enhatls158334	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75552		-0.63467			SOSTDC1	chr7	16461480	16530580	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	974
enhrx-148212	chr7	16961778	16961804	16922154	16922180	4747	hg19	N/A	enh39915	fant25645	Enhatls158385	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67675		-0.61916			AGR3	chr7	16859411	16881987	40070	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1024
enhrx-148212	chr7	17081103	17081130	17041479	17041506	4748	hg19	N/A	enh24004	fant25649	Enhatls158385	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.53767		-0.78867			AHR	chr7	17132189	17346150	90514	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1024
enhrx-148212	chr7	17081190	17081217	17041566	17041593	4749	hg19	N/A	enh24004	fant25649	Enhatls158385	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68784		-0.42445			AHR	chr7	17132189	17346150	90514	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1024
enhrx-148297	chr7	20280139	20280165	20240516	20240542	4750	hg19	N/A	enh24018	N/A	Enhatls158484	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.55026		-0.79115			MACC1	chr7	20134654	20217404	20530	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1109
enhrx-148689	chr7	27784848	27784872	27745229	27745253	4751	hg19	N/A	enh9682	N/A	Enhatls158902	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.28608		-0.54224			TAX1BP1	chr7	27739330	27844564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1501
enhrx-149030	chr7	33574706	33574735	33535094	33535123	4752	hg19	N/A	N/A	N/A	Enhatls159276	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15794		-0.51701			BBS9	chr7	33109556	33635767	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1842
enhrx-150356	chr7	69427306	69427338	69962320	69962352	4753	hg19	N/A	enh49263	N/A	Enhatls160732	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8526		-0.45689			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3168
enhrx-150358	chr7	69675391	69675420	70210405	70210434	4754	hg19	N/A	enh40247	N/A	Enhatls160734	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6992		-0.62358			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3170
enhrx-150358	chr7	69675719	69675745	70210733	70210759	4755	hg19	N/A	enh40247	N/A	Enhatls160734	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.03305		-0.49242			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3170
enhrx-150358	chr7	69676109	69676136	70211123	70211150	4756	hg19	N/A	enh40247	N/A	Enhatls160734	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73439		-0.63051			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3170
enhrx-150360	chr7	70049366	70049393	70584380	70584407	4757	hg19	N/A	enh40252	N/A	Enhatls160736	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.48974		-0.58234			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3172
enhrx-150360	chr7	70053205	70053233	70588219	70588247	4758	hg19	N/A	enh40252	N/A	Enhatls160736	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66989		-0.61781			AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3172
enhrx-151139	chr7	79909372	79909400	80280056	80280084	4759	hg19	N/A	enh40303	N/A	Enhatls161575	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.62428		-0.60883			GNAI1	chr7	79768049	80226181	45229	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3951
enhrx-151158	chr7	80354135	80354164	80724819	80724848	4760	hg19	N/A	enh40310	N/A	Enhatls161597	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.722237		0.44387			SEMA3C	chr7	80742537	80922359	15882	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3970
enhrx-151172	chr7	80471365	80471394	80842049	80842078	4761	hg19	N/A	enh40312	N/A	Enhatls161614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6188		-0.60775			SEMA3C	chr7	80742537	80922359	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3984
enhrx-151172	chr7	80511959	80511986	80882643	80882670	4762	hg19	N/A	enh24295	N/A	Enhatls161614	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.14106		-0.71058			SEMA3C	chr7	80742537	80922359	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3984
enhrx-151176	chr7	80693766	80693788	81064450	81064472	4763	hg19	N/A	enh84684	N/A	Enhatls161617	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.7351		-0.63065			SEMA3C	chr7	80742537	80922359	138511	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3988
enhrx-151288	chr7	83654881	83654908	84025565	84025592	4764	hg19	N/A	enh40347	N/A	Enhatls161738	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18308		-0.52196			SEMA3A	chr7	83955776	84492724	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4100
enhrx-151709	chr7	92262510	92262530	92633196	92633216	4765	hg19	N/A	enh9916	N/A	Enhatls162174	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.68965		-0.6217			CDK6	chr7	92604920	92836573	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-151709	chr7	92262532	92262553	92633218	92633239	4766	hg19	N/A	enh9916	N/A	Enhatls162174	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.27847		-0.93453			CDK6	chr7	92604920	92836573	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-151710	chr7	92320939	92320974	92691625	92691660	4767	hg19	N/A	enh24319	N/A	Enhatls162175	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38771		-0.56225			CDK6	chr7	92604920	92836573	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4522
enhrx-151710	chr7	92328038	92328065	92698724	92698751	4768	hg19	N/A	enh24319	N/A	Enhatls162175	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46877		-0.57821			CDK6	chr7	92604920	92836573	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4522
enhrx-151710	chr7	92328217	92328245	92698903	92698931	4769	hg19	N/A	enh24319	N/A	Enhatls162175	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.827696		0.26774			CDK6	chr7	92604920	92836573	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4522
enhrx-151714	chr7	92644748	92644775	93015434	93015461	4770	hg19	N/A	enh24327	N/A	Enhatls162183	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.688767		0.43728			SAMD9	chr7	93099512	93118023	80252	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4526
enhrx-151714	chr7	92645568	92645595	93016254	93016281	4771	hg19	N/A	enh24327	N/A	Enhatls162183	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98435		-0.48283			SAMD9	chr7	93099512	93118023	80252	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4526
enhrx-151789	chr7	93933223	93933252	94303911	94303940	4772	hg19	N/A	enh24335	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25601		-0.53632			COL1A2	chr7	94394894	94431227	82992	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93943612	93943638	94314300	94314326	4773	hg19	N/A	enh40412	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.81007		-0.64541			COL1A2	chr7	94394894	94431227	77612	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93943669	93943696	94314357	94314384	4774	hg19	N/A	enh40412	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.778685		0.25809			COL1A2	chr7	94394894	94431227	77612	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93943870	93943897	94314558	94314585	4775	hg19	N/A	enh40412	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.03831		-0.69035			COL1A2	chr7	94394894	94431227	77612	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93943929	93943956	94314617	94314644	4776	hg19	N/A	enh40412	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18298		-0.52194			COL1A2	chr7	94394894	94431227	77612	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93977520	93977548	94348208	94348236	4777	hg19	hs1626	enh40414	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.70732		-0.62518			COL1A2	chr7	94394894	94431227	45327	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93997095	93997122	94367783	94367810	4778	hg19	N/A	enh40415	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.19164		-0.72054			COL1A2	chr7	94394894	94431227	26619	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93997153	93997180	94367841	94367868	4779	hg19	N/A	enh40415	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.22999		-0.72809			COL1A2	chr7	94394894	94431227	26619	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93997408	93997435	94368096	94368123	4780	hg19	N/A	enh40415	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40417		-0.56549			COL1A2	chr7	94394894	94431227	26619	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	93997825	93997853	94368513	94368541	4781	hg19	N/A	enh40415	fant27067	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.53431		-0.78801			COL1A2	chr7	94394894	94431227	26222	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151789	chr7	94003659	94003689	94374347	94374377	4782	hg19	N/A	enh24336	N/A	Enhatls162258	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17597		-0.52056			COL1A2	chr7	94394894	94431227	7134	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4601
enhrx-151832	chr7	94069889	94069918	94440577	94440606	4783	hg19	N/A	enh24337	N/A	Enhatls162300	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.77846		-0.83608			COL1A2	chr7	94394894	94431227	6367	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4644
enhrx-151954	chr7	96018063	96018093	96388751	96388781	4784	hg19	N/A	enh84740	N/A	Enhatls162422	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.85285		-0.45694			SLC25A13	chr7	96120219	96322147	64167	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4766
enhrx-151954	chr7	96018194	96018223	96388882	96388911	4785	hg19	N/A	enh84740	N/A	Enhatls162422	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.124686		0.52311			SLC25A13	chr7	96120219	96322147	64167	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4766
enhrx-152565	chr7	100434032	100434059	100836410	100836437	4786	hg19	N/A	enh9944	N/A	Enhatls163052	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71908		-0.4306			EPHB4	chr7	100802564	100827523	8625	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5377
enhrx-153350	chr7	108233257	108233286	108592813	108592842	4787	hg19	N/A	enh46454	N/A	Enhatls163872	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.78511		-0.83739			DNAJB9	chr7	108569873	108574850	13176	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6162
enhrx-153354	chr7	110161623	110161650	110521566	110521593	4788	hg19	N/A	enh40480	N/A	Enhatls163876	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.82782		-0.45201			IMMP2L	chr7	110662643	111562517	137466	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6166
enhrx-153357	chr7	110666521	110666548	111026465	111026492	4789	hg19	N/A	enh49305	N/A	Enhatls163879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.48847		-0.58209			IMMP2L	chr7	110662643	111562517	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6169
enhrx-153357	chr7	110667022	110667060	111026966	111027004	4790	hg19	N/A	enh49305	N/A	Enhatls163879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.58335		-0.60077			IMMP2L	chr7	110662643	111562517	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6169
enhrx-153479	chr7	114271133	114271161	114631078	114631106	4791	hg19	N/A	N/A	N/A	Enhatls164002	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1389		-0.51326			FOXP2	chr7	114086490	114693772	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6291
enhrx-153531	chr7	116442969	116442992	116802915	116802938	4792	hg19	N/A	enh24456	N/A	Enhatls164068	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.264733		0.35379			MET	chr7	116672195	116798377	10	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6343
enhrx-153607	chr7	117314758	117314792	117674704	117674738	4793	hg19	N/A	enh24464	N/A	Enhatls164158	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.32255		-0.54942			CFTR	chr7	117287119	117715948	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6419
enhrx-153673	chr7	120664495	120664524	121024441	121024470	4794	hg19	N/A	enh40559	N/A	Enhatls164225	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83163		-0.45276			CPED1	chr7	120988696	121297442	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6485
enhrx-154485	chr7	134564788	134564816	134880037	134880065	4795	hg19	N/A	enh24545	N/A	Enhatls165093	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.515679		0.4032			CALD1	chr7	134744251	134970729	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7297
enhrx-154626	chr7	137131113	137131141	137446367	137446395	4796	hg19	N/A	N/A	N/A	Enhatls165243	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.163257		0.33381			DGKI	chr7	137381036	137847092	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7438
enhrx-155379	chr7	147868897	147868922	148171805	148171830	4797	hg19	N/A	N/A	N/A	Enhatls166009	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.817262		0.46258			CNTNAP2	chr7	146116001	148420998	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8191
enhrx-155423	chr7	148638568	148638599	148941476	148941507	4798	hg19	N/A	enh10091	fant28107	Enhatls166057	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9862		-0.68009			EZH2	chr7	148807382	148884291	56806	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8235
enhrx-156597	chr8	8458446	8458475	8600936	8600965	4799	hg19	N/A	enh24724	N/A	Enhatls167281	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.93854		-0.47381			CLDN23	chr8	8701936	8704096	98652	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	388
enhrx-156597	chr8	8506478	8506504	8648968	8648994	4800	hg19	N/A	enh10144	N/A	Enhatls167281	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.08463		-0.69947			CLDN23	chr8	8701936	8704096	50872	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	388
enhrx-156600	chr8	8730232	8730254	8872722	8872744	4801	hg19	N/A	enh10152	N/A	Enhatls167284	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.117474		0.52169			MFHAS1	chr8	8783353	8893630	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	391
enhrx-156607	chr8	8932500	8932532	9074990	9075022	4802	hg19	N/A	enh24735	fant28620	Enhatls167293	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.0557		-0.49688			ERI1	chr8	9002843	9116746	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	398
enhrx-156607	chr8	8966571	8966592	9109061	9109082	4803	hg19	N/A	N/A	N/A	Enhatls167293	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69724		-0.4263			ERI1	chr8	9002843	9116746	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	398
enhrx-156827	chr8	12923105	12923147	13065596	13065638	4804	hg19	N/A	enh56588	N/A	Enhatls167537	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56176		-0.59652			DLC1	chr8	13083360	13604606	15355	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	618
enhrx-156841	chr8	13098717	13098737	13241208	13241228	4805	hg19	N/A	enh24753	N/A	Enhatls167552	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.457475		0.39174			DLC1	chr8	13083360	13604606	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	632
enhrx-156842	chr8	13223549	13223570	13366040	13366061	4806	hg19	N/A	enh24756	N/A	Enhatls167553	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.242132		0.34934			DLC1	chr8	13083360	13604606	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	633
enhrx-157042	chr8	18835251	18835289	18977741	18977779	4807	hg19	N/A	enh40791	N/A	Enhatls167765	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49487		-0.58335			PSD3	chr8	18527302	19084730	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	833
enhrx-157429	chr8	23849250	23849277	23991737	23991764	4808	hg19	N/A	enh24845	N/A	Enhatls168189	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.417251		0.38382			STC1	chr8	23841928	23854806	133167	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1220
enhrx-157592	chr8	26346368	26346396	26488852	26488880	4809	hg19	N/A	N/A	N/A	Enhatls168358	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.50874		-0.97987			BNIP3L	chr8	26383053	26505636	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1383
enhrx-157849	chr8	29380344	29380372	29522827	29522855	4810	hg19	N/A	enh10213	N/A	Enhatls168631	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92172		-0.4705			DUSP4	chr8	29333063	29350684	168605	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1640
enhrx-157972	chr8	32962754	32962781	33105236	33105263	4811	hg19	N/A	enh40890	N/A	Enhatls168777	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.933134		0.2885			NRG1	chr8	31639221	32855666	249523	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1763
enhrx-158372	chr8	39898715	39898742	40041196	40041223	4812	hg19	N/A	enh24942	N/A	Enhatls169205	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98054		-0.48208			IDO2	chr8	39934650	40016392	21657	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2163
enhrx-158373	chr8	40269787	40269815	40412268	40412296	4813	hg19	N/A	enh24950	N/A	Enhatls169206	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.41621		-0.96165			ZMAT4	chr8	40530589	40897833	112454	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2164
enhrx-158373	chr8	40276711	40276740	40419192	40419221	4814	hg19	N/A	N/A	N/A	Enhatls169206	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.47974		-0.97416			ZMAT4	chr8	40530589	40897833	91864	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2164
enhrx-159650	chr8	74378649	74378675	73466414	73466440	4815	hg19	N/A	enh41099	N/A	Enhatls170537	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.72532		-0.43183			STAU2	chr8	73420368	73747708	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3441
enhrx-160048	chr8	89246996	89247029	88234767	88234800	4816	hg19	N/A	enh41202	N/A	Enhatls170957	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.36824		0.37417			MMP16	chr8	88032010	88328025	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3839
enhrx-160084	chr8	91022299	91022332	90010071	90010104	4817	hg19	N/A	enh66575	N/A	Enhatls170996	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.54002		-0.59224			DECR1	chr8	90001475	90053633	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3875
enhrx-160233	chr8	94892701	94892725	93880473	93880497	4818	hg19	N/A	enh25125	fant30153	Enhatls171156	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.703851		0.44025			PDP1	chr8	93916855	93926068	36287	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4024
enhrx-160408	chr8	97351593	97351619	96339365	96339391	4819	hg19	N/A	enh25132	N/A	Enhatls171339	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	5.186755		0.92912			PTDSS1	chr8	96261901	96336995	1341	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4199
enhrx-160420	chr8	98073216	98073248	97060988	97061020	4820	hg19	N/A	enh85146	N/A	Enhatls171354	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.71403		-0.6265			CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4211
enhrx-160420	chr8	98073250	98073282	97061022	97061054	4821	hg19	N/A	enh85146	N/A	Enhatls171354	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	5.333687		0.95805			CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4211
enhrx-160420	chr8	98073284	98073316	97061056	97061088	4822	hg19	N/A	enh85146	N/A	Enhatls171354	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.64453		0.42857			CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4211
enhrx-160536	chr8	100511096	100511124	99498868	99498896	4823	hg19	N/A	enh10444	N/A	Enhatls171475	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.14844		-0.51514			VPS13B	chr8	99013273	99877580	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4327
enhrx-160536	chr8	100511156	100511184	99498928	99498956	4824	hg19	N/A	enh10444	N/A	Enhatls171475	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.70994		-0.82259			VPS13B	chr8	99013273	99877580	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4327
enhrx-160670	chr8	102094277	102094315	101082049	101082087	4825	hg19	N/A	enh25175	N/A	Enhatls171616	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.13803		-0.51309			ZNF706	chr8	101177877	101206193	94719	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4461
enhrx-160670	chr8	102161945	102161970	101149717	101149742	4826	hg19	N/A	enh25176	fant30316	Enhatls171616	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.61121		-0.80315			ZNF706	chr8	101177877	101206193	27821	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4461
enhrx-160682	chr8	102626226	102626258	101613998	101614030	4827	hg19	N/A	enh25184	N/A	Enhatls171630	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.385457		0.37756			GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4473
enhrx-160682	chr8	102626960	102626989	101614732	101614761	4828	hg19	N/A	enh25184	N/A	Enhatls171630	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09786		-0.50518			GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4473
enhrx-160799	chr8	104357125	104357153	103344897	103344925	4829	hg19	N/A	enh25211	fant30422	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-5.78928		-1.232			FZD6	chr8	103298432	103332866	11972	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160799	chr8	104357402	104357424	103345174	103345196	4830	hg19	N/A	enh25211	fant30422	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09984		-0.50557			FZD6	chr8	103298432	103332866	11972	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160799	chr8	104357402	104357424	103345174	103345196	4831	hg19	N/A	enh25211	N/A	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09984		-0.50557			FZD6	chr8	103298432	103332866	12319	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160799	chr8	104369252	104369286	103357024	103357058	4832	hg19	N/A	enh25211	N/A	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99928		-0.48577			CTHRC1	chr8	103371537	103382989	12258	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160799	chr8	104369418	104369446	103357190	103357218	4833	hg19	N/A	enh25211	N/A	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68667		-0.42422			CTHRC1	chr8	103371537	103382989	12258	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160799	chr8	104369506	104369534	103357278	103357306	4834	hg19	N/A	enh25211	N/A	Enhatls171751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79963		-0.44646			CTHRC1	chr8	103371537	103382989	12258	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4590
enhrx-160913	chr8	108434337	108434374	107422109	107422146	4835	hg19	N/A	enh100851	N/A	Enhatls171867	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.216026		0.3442			ANGPT1	chr8	107249481	107498055	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4704
enhrx-161179	chr8	118164391	118164412	117152152	117152173	4836	hg19	N/A	N/A	N/A	Enhatls172145	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49751		-0.58387			SLC30A8	chr8	116950272	117176714	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4970
enhrx-161184	chr8	118184207	118184241	117171968	117172002	4837	hg19	N/A	N/A	N/A	Enhatls172150	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.016833		0.30498			SLC30A8	chr8	116950272	117176714	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4975
enhrx-lit71	chr8	118187637	118187668	117175398	117175429	4838	hg19					enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.460167		0.39227								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-lit72	chr8	118188920	118188948	117176681	117176709	4839	hg19					enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.920922		0.48299								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-161197	chr8	118907879	118907907	117895640	117895668	4840	hg19	N/A	enh59903	N/A	Enhatls172165	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.325425		0.36574			EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4988
enhrx-161197	chr8	118911010	118911030	117898771	117898791	4841	hg19	N/A	enh59903	N/A	Enhatls172165	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	4.562258		0.80616			EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4988
enhrx-161197	chr8	118911089	118911116	117898850	117898877	4842	hg19	N/A	enh59903	N/A	Enhatls172165	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.343303		0.36926			EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4988
enhrx-161457	chr8	124720318	124720346	123708078	123708106	4843	hg19	N/A	enh25272	N/A	Enhatls172448	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56674		-0.5975			ANXA13	chr8	123680793	123737402	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5248
enhrx-161610	chr8	126231935	126231963	125219693	125219721	4844	hg19	N/A	enh10517	N/A	Enhatls172605	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.347163		0.37002			NSMCE2	chr8	125091678	125367120	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5401
enhrx-161706	chr8	131281112	131281140	130268866	130268894	4845	hg19	N/A	enh10561	N/A	Enhatls172735	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36663		-0.5581			ASAP1	chr8	130052103	130443674	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5497
enhrx-162934	chr9	3916294	3916324	3916294	3916324	4846	hg19	N/A	enh56893	N/A	Enhatls174008	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92955		-0.47204			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	201
enhrx-162934	chr9	3929942	3929970	3929942	3929970	4847	hg19	N/A	N/A	N/A	Enhatls174008	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.77809		-0.44222			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	201
enhrx-162934	chr9	3931405	3931447	3931405	3931447	4848	hg19	N/A	N/A	N/A	Enhatls174008	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99999		-0.48591			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	201
enhrx-162936	chr9	4084601	4084628	4084601	4084628	4849	hg19	N/A	enh41684	N/A	Enhatls174010	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.96637		-0.47929			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	203
enhrx-162936	chr9	4109245	4109273	4109245	4109273	4850	hg19	N/A	enh25426	N/A	Enhatls174010	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.34584		-0.7509			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	203
enhrx-162938	chr9	4137748	4137775	4137748	4137775	4851	hg19	N/A	enh25427	N/A	Enhatls174012	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.96271		-0.47857			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	205
enhrx-162938	chr9	4137924	4137951	4137924	4137951	4852	hg19	N/A	enh25427	N/A	Enhatls174012	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.55201		-0.5946			GLIS3	chr9	3824126	4300068	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	205
enhrx-163165	chr9	7690671	7690698	7690671	7690698	4853	hg19	N/A	N/A	N/A	Enhatls174240	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.342388		0.36908			DMAC1	chr9	7796499	7799778	42275	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	432
enhrx-163206	chr9	8784001	8784030	8784001	8784030	4854	hg19	N/A	enh100874	N/A	Enhatls174280	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.606794		0.42114			PTPRD	chr9	8314245	10613002	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	473
enhrx-163206	chr9	8784943	8784970	8784943	8784970	4855	hg19	N/A	enh100874	N/A	Enhatls174280	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.02562		0.30671			PTPRD	chr9	8314245	10613002	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	473
enhrx-163281	chr9	13897327	13897354	13897328	13897355	4856	hg19	N/A	enh63865	N/A	Enhatls174359	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.673276		0.43423			NFIB	chr9	14081842	14398983	178463	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	548
enhrx-163283	chr9	14030328	14030356	14030329	14030357	4857	hg19	N/A	enh25470	N/A	Enhatls174362	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.78526		-0.44363			NFIB	chr9	14081842	14398983	51421	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	550
enhrx-163283	chr9	14030688	14030716	14030689	14030717	4858	hg19	N/A	enh25470	N/A	Enhatls174362	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.813729		0.26499			NFIB	chr9	14081842	14398983	48407	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	550
enhrx-163284	chr9	14095521	14095547	14095522	14095548	4859	hg19	N/A	N/A	N/A	Enhatls174363	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.83925		-0.84805			NFIB	chr9	14081842	14398983	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	551
enhrx-163285	chr9	14108313	14108342	14108314	14108343	4860	hg19	N/A	enh73563	N/A	Enhatls174364	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12432		-0.51039			NFIB	chr9	14081842	14398983	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	552
enhrx-163427	chr9	16421626	16421653	16421628	16421655	4861	hg19	N/A	N/A	N/A	Enhatls174511	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.23199		-0.53159			BNC2	chr9	16409502	16870843	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	694
enhrx-163427	chr9	16422366	16422394	16422368	16422396	4862	hg19	N/A	N/A	N/A	Enhatls174511	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.338528		0.36832			BNC2	chr9	16409502	16870843	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	694
enhrx-163427	chr9	16425231	16425259	16425233	16425261	4863	hg19	N/A	enh41753	N/A	Enhatls174511	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.020084		0.30562			BNC2	chr9	16409502	16870843	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	694
enhrx-163683	chr9	22103595	22103624	22103596	22103625	4864	hg19	hs1520	enh10699	N/A	Enhatls174778	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.26701		-0.73538			CDKN2B	chr9	22002902	22009305	93361	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	950
enhrx-163819	chr9	27437648	27437673	27437650	27437675	4865	hg19	N/A	enh25517	N/A	Enhatls174933	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.45582		-0.57566			MOB3B	chr9	27325208	27529814	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1086
enhrx-163820	chr9	27472710	27472750	27472712	27472752	4866	hg19	N/A	enh25518	N/A	Enhatls174934	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.332434		0.36712			MOB3B	chr9	27325208	27529814	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1087
enhrx-163834	chr9	27600937	27600965	27600939	27600967	4867	hg19	N/A	enh100906	N/A	Enhatls174947	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22671		-0.53055			C9orf72	chr9	27546545	27573866	26800	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1101
enhrx-164426	chr9	36499315	36499341	36499318	36499344	4868	hg19	N/A	enh10727	N/A	Enhatls175562	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.256556		0.35218			MELK	chr9	36572861	36677683	66444	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1693
enhrx-164426	chr9	36499572	36499599	36499575	36499602	4869	hg19	N/A	enh10727	N/A	Enhatls175562	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83975		-0.45436			MELK	chr9	36572861	36677683	66444	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1693
enhrx-165137	chr9	73864850	73864876	71249934	71249960	4870	hg19	N/A	enh73654	N/A	Enhatls176727	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26414		-0.53792			TRPM3	chr9	70529059	71446835	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2404
enhrx-165385	chr9	79450733	79450764	76835817	76835848	4871	hg19	N/A	enh41967	N/A	Enhatls176994	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.318292		0.56123			PRUNE2	chr9	76611375	76906114	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2652
enhrx-165667	chr9	87506922	87506949	84892007	84892034	4872	hg19	N/A	enh57020	N/A	Enhatls177295	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92675		-0.47149			NTRK2	chr9	84668374	85095751	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2934
enhrx-166252	chr9	98068230	98068257	95305948	95305975	4873	hg19	N/A	enh49521	N/A	Enhatls177942	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30767		-0.54649			FANCC	chr9	95099053	95317715	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3519
enhrx-166252	chr9	98068642	98068670	95306360	95306388	4874	hg19	N/A	enh49521	N/A	Enhatls177942	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.59361		-0.60279			FANCC	chr9	95099053	95317715	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3519
enhrx-166867	chr9	107891465	107891496	105129184	105129215	4875	hg19	N/A	enh25830	N/A	Enhatls178603	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.79948		-0.84022			SLC44A1	chr9	105244621	105439171	109768	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4134
enhrx-166918	chr9	109344927	109344963	106582646	106582682	4876	hg19	N/A	enh59987	N/A	Enhatls178653	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00461		-0.48682			ZNF462	chr9	106863165	107013634	271939	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4185
enhrx-166926	chr9	109655170	109655197	106892889	106892916	4877	hg19	N/A	enh25840	N/A	Enhatls178663	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.44195		-0.57293			ZNF462	chr9	106863165	107013634	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4193
enhrx-166943	chr9	109938728	109938757	107176447	107176476	4878	hg19	N/A	enh25843	N/A	Enhatls178680	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.20454		-0.72308			RAD23B	chr9	107283136	107332192	102643	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4210
enhrx-166943	chr9	109938883	109938912	107176602	107176631	4879	hg19	N/A	enh25843	N/A	Enhatls178680	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.19723		-0.72164			RAD23B	chr9	107283136	107332192	102643	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4210
enhrx-166943	chr9	109939198	109939226	107176917	107176945	4880	hg19	N/A	enh25843	N/A	Enhatls178680	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.56979		-0.5981			RAD23B	chr9	107283136	107332192	102643	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4210
enhrx-167623	chr9	118361109	118361136	115598830	115598857	4881	hg19	N/A	enh25935	N/A	Enhatls179397	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.82482		-0.45142			TNC	chr9	115019574	115118207	478542	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4890
enhrx-167657	chr9	119334522	119334550	116572243	116572271	4882	hg19	N/A	enh57146	N/A	Enhatls179442	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25607		-0.53633			ASTN2	chr9	116423111	117415070	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4924
enhrx-167657	chr9	119334552	119334580	116572273	116572301	4883	hg19	N/A	enh57146	N/A	Enhatls179442	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.39729		-0.76103			ASTN2	chr9	116423111	117415070	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4924
enhrx-170138	chr9	140301616	140301640	137407164	137407188	4884	hg19	N/A	enh26123	fant34279	Enhatls182062	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16708		-0.51881			EXD3	chr9	137306895	137423162	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7405
enhrx-18003	chr10	7899389	7899417	7857426	7857454	4885	hg19	N/A	enh12957	N/A	Enhatls19667	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01705		-0.48927			TAF3	chr10	7818504	8016631	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	438
enhrx-18035	chr10	11189522	11189551	11147559	11147588	4886	hg19	N/A	enh47349	N/A	Enhatls19711	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.291679		0.55599			CELF2	chr10	10798396	11336675	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	470
enhrx-18425	chr10	17065528	17065556	17023529	17023557	4887	hg19	N/A	enh13024	N/A	Enhatls20124	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.25421		-0.73286			CUBN	chr10	16823965	17129811	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	860
enhrx-18425	chr10	17065620	17065649	17023621	17023650	4888	hg19	N/A	enh13024	N/A	Enhatls20124	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.62875		-0.60971			CUBN	chr10	16823965	17129811	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	860
enhrx-18425	chr10	17066064	17066089	17024065	17024090	4889	hg19	N/A	enh13024	N/A	Enhatls20124	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40648		-0.76284			CUBN	chr10	16823965	17129811	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	860
enhrx-18823	chr10	25349182	25349207	25060253	25060278	4890	hg19	N/A	enh27924	fant35128	Enhatls20582	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1807		-0.52149			ENKUR	chr10	24981979	25062279	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-18823	chr10	25351300	25351321	25062371	25062392	4891	hg19	N/A	enh27924	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.48879		-0.97594			ENKUR	chr10	24981979	25062279	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-18823	chr10	25370140	25370172	25081211	25081243	4892	hg19	N/A	enh27925	N/A	Enhatls20584	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07836		-0.50134			ENKUR	chr10	24981979	25062279	14818	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-18823	chr10	25371653	25371679	25082724	25082750	4893	hg19	N/A	enh27925	N/A	Enhatls20584	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.55991		-0.79305			ENKUR	chr10	24981979	25062279	14818	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-18823	chr10	25371710	25371736	25082781	25082807	4894	hg19	N/A	enh27925	N/A	Enhatls20584	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57187		-0.59851			ENKUR	chr10	24981979	25062279	14818	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-18823	chr10	25371738	25371765	25082809	25082836	4895	hg19	N/A	enh27925	N/A	Enhatls20584	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20284		-0.52585			ENKUR	chr10	24981979	25062279	14818	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1258
enhrx-19335	chr10	35081779	35081814	34792851	34792886	4896	hg19	N/A	enh1178	N/A	Enhatls21132	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11218		-0.508			PARD3	chr10	34109559	34815325	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1770
enhrx-20426	chr10	63515764	63515790	61756006	61756032	4897	hg19	N/A	enh28150	N/A	Enhatls22508	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.81375		-0.84303			CABCOCO1	chr10	61662928	61766766	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2861
enhrx-20429	chr10	63703160	63703187	61943401	61943428	4898	hg19	N/A	enh13250	fant35794	Enhatls22514	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.28263		-0.54156			ARID5B	chr10	61901683	62096944	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2864
enhrx-20429	chr10	63703160	63703187	61943401	61943428	4899	hg19	N/A	enh13250	N/A	Enhatls22514	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.28263		-0.54156			ARID5B	chr10	61901683	62096944	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2864
enhrx-20470	chr10	64519727	64519764	62759967	62760004	4900	hg19	N/A	enh13257	fant35856	Enhatls22557	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2358		-0.53234			ADO	chr10	62804719	62808479	44715	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2905
enhrx-20470	chr10	64532088	64532116	62772328	62772356	4901	hg19	N/A	N/A	N/A	Enhatls22557	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.216687		0.34433			ADO	chr10	62804719	62808479	31906	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2905
enhrx-20507	chr10	65471092	65471119	63711332	63711359	4902	hg19	N/A	enh1253	N/A	Enhatls22596	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.51331		-0.58698			REEP3	chr10	63521400	63625128	82518	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2942
enhrx-20507	chr10	65471890	65471914	63712130	63712154	4903	hg19	N/A	enh1253	N/A	Enhatls22596	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40041		-0.56475			REEP3	chr10	63521400	63625128	82518	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2942
enhrx-20507	chr10	65473458	65473483	63713698	63713723	4904	hg19	N/A	enh1253	N/A	Enhatls22596	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1293		-0.51137			REEP3	chr10	63521400	63625128	82518	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2942
enhrx-20706	chr10	70631701	70631729	68871945	68871973	4905	hg19	N/A	enh28192	N/A	Enhatls22798	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86588		-0.6564			STOX1	chr10	68827530	68895432	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3141
enhrx-21107	chr10	74496147	74496174	72736389	72736416	4906	hg19	N/A	enh28214	N/A	Enhatls23230	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.13763		-0.51301			MCU	chr10	72692142	72887694	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3542
enhrx-21420	chr10	78057636	78057665	76297878	76297907	4907	hg19	N/A	enh28241	N/A	Enhatls23565	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.742247		0.44781			LRMDA	chr10	75431623	76560168	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3855
enhrx-21420	chr10	78061496	78061525	76301738	76301767	4908	hg19	N/A	enh28241	N/A	Enhatls23565	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.111785		0.52057			LRMDA	chr10	75431623	76560168	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3855
enhrx-21484	chr10	79727413	79727441	77967655	77967683	4909	hg19	N/A	enh28264	N/A	Enhatls23633	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.08415		-0.50248			POLR3A	chr10	77975148	78029515	3830	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3919
enhrx-22343	chr10	95575631	95575657	93815874	93815900	4910	hg19	N/A	enh50555	N/A	Enhatls24572	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.49709		-0.78068			LGI1	chr10	93757850	93806134	4615	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4778
enhrx-22486	chr10	97020922	97020949	95261165	95261192	4911	hg19	N/A	enh13417	N/A	Enhatls24720	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.7929		-0.64203			PDLIM1	chr10	95237571	95291003	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4921
enhrx-23259	chr10	104070639	104070667	102310882	102310910	4912	hg19	N/A	enh1479	N/A	Enhatls25537	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.032781		0.30812			GBF1	chr10	102245370	102382899	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5694
enhrx-23259	chr10	104070757	104070785	102311000	102311028	4913	hg19	N/A	enh1479	N/A	Enhatls25537	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6122		-0.60645			GBF1	chr10	102245370	102382899	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5694
enhrx-23408	chr10	104988057	104988083	103228300	103228326	4914	hg19	N/A	enh13473	N/A	Enhatls25694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06998		-0.49969			NT5C2	chr10	103088017	103277605	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5843
enhrx-23479	chr10	105572458	105572487	103812700	103812729	4915	hg19	N/A	enh13484	N/A	Enhatls25781	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66989		-0.61781			SH3PXD2A	chr10	103594026	103855584	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5914
enhrx-23711	chr10	111717108	111717137	109957350	109957379	4916	hg19	N/A	N/A	N/A	Enhatls26026	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1875		-0.52283			XPNPEP1	chr10	109864765	109923553	30340	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6146
enhrx-23860	chr10	114389980	114390009	112630221	112630250	4917	hg19	N/A	enh50618	N/A	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.859		-0.45815			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6295
enhrx-23862	chr10	114483861	114483891	112724102	112724132	4918	hg19	N/A	enh1514	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.30927		-0.7437			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114484036	114484071	112724277	112724312	4919	hg19	N/A	enh1514	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.504026		0.5978			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114491796	114491825	112732037	112732066	4920	hg19	N/A	enh1514	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.63665		-0.80816			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114492219	114492247	112732460	112732488	4921	hg19	N/A	enh1514	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.04232		-0.69114			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114492608	114492637	112732849	112732878	4922	hg19	N/A	enh1514	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.287943		0.35836			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114498959	114498987	112739200	112739228	4923	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.12361		-0.51025			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114499554	114499583	112739795	112739824	4924	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8816		-0.4626			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114499646	114499675	112739887	112739916	4925	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-5.69989		-1.2144			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114501844	114501872	112742085	112742113	4926	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.74988		-0.63356			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114502594	114502622	112742835	112742863	4927	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.577009		0.61217			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23862	chr10	114503307	114503331	112743548	112743572	4928	hg19	N/A	enh43412	N/A	Enhatls26194	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49944		-0.58425			VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6297
enhrx-23870	chr10	114803645	114803674	113043886	113043915	4929	hg19	N/A	enh13510	N/A	Enhatls26201	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06586		-0.49888			TCF7L2	chr10	112950246	113167678	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6305
enhrx-23870	chr10	114806759	114806784	113047000	113047025	4930	hg19	N/A	enh13510	N/A	Enhatls26201	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.72197		-0.43117			TCF7L2	chr10	112950246	113167678	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6305
enhrx-23870	chr10	114818636	114818668	113058877	113058909	4931	hg19	N/A	enh13510	fant37057	Enhatls26201	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68459		-0.42381			TCF7L2	chr10	112950246	113167678	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6305
enhrx-23870	chr10	114820409	114820439	113060650	113060680	4932	hg19	N/A	enh13510	N/A	Enhatls26201	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92294		-0.47074			TCF7L2	chr10	112950246	113167678	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6305
enhrx-24346	chr10	121511514	121511543	119752002	119752031	4933	hg19	N/A	enh28501	N/A	Enhatls26713	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.089388		0.51616			INPP5F	chr10	119726049	119829147	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6781
enhrx-25781	chr11	2224662	2224689	2203432	2203459	4934	hg19	N/A	enh13693	N/A	Enhatls28144	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69307		-0.42548			TH	chr11	2163928	2171815	30936	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	450
enhrx-26336	chr11	7912408	7912435	7890861	7890888	4935	hg19	N/A	enh1625	N/A	Enhatls28704	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.23621		-0.53242			OR10A6	chr11	7924591	7931268	32434	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1005
enhrx-26646	chr11	10953357	10953379	10931810	10931832	4936	hg19	N/A	enh13765	N/A	Enhatls29055	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.22804		-0.9246			ZBED5	chr11	10852703	10858796	68329	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1315
enhrx-26728	chr11	12620316	12620344	12598769	12598797	4937	hg19	N/A	enh28600	N/A	Enhatls29146	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11355		-0.50827			PARVA	chr11	12377570	12535356	61363	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1397
enhrx-26729	chr11	12824456	12824483	12802909	12802936	4938	hg19	N/A	enh13788	N/A	Enhatls29149	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16906		-0.5192			TEAD1	chr11	12674420	12944737	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1398
enhrx-26885	chr11	15686773	15686800	15665227	15665254	4939	hg19	N/A	enh13806	N/A	Enhatls29306	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.81431		-0.84314			SOX6	chr11	15966448	16476388	298780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1554
enhrx-26885	chr11	15686831	15686858	15665285	15665312	4940	hg19	N/A	enh13806	N/A	Enhatls29306	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-8.0057		-1.6684			SOX6	chr11	15966448	16476388	298780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1554
enhrx-26885	chr11	15860643	15860671	15839097	15839125	4941	hg19	N/A	enh50730	N/A	Enhatls29308	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16241		-0.51789			SOX6	chr11	15966448	16476388	120280	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1554
enhrx-26894	chr11	16170113	16170141	16148567	16148595	4942	hg19	N/A	enh50733	N/A	Enhatls29318	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.65894		-0.41876			SOX6	chr11	15966448	16476388	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1563
enhrx-26899	chr11	16377385	16377413	16355839	16355867	4943	hg19	N/A	enh28623	N/A	Enhatls29323	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.338325		0.36828			SOX6	chr11	15966448	16476388	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1568
enhrx-26899	chr11	16379355	16379383	16357809	16357837	4944	hg19	N/A	enh28623	N/A	Enhatls29323	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.03804		0.50605			SOX6	chr11	15966448	16476388	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1568
enhrx-26921	chr11	16946497	16946526	16924950	16924979	4945	hg19	N/A	enh13814	N/A	Enhatls29351	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36841		-0.55845			PLEKHA7	chr11	16777296	17014415	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1590
enhrx-27292	chr11	19912783	19912811	19891237	19891265	4946	hg19	N/A	enh28640	N/A	Enhatls29727	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.42512		-0.76651			NAV2	chr11	19350723	20121601	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1961
enhrx-27514	chr11	27256031	27256066	27234484	27234519	4947	hg19	N/A	enh1684	fant38163	Enhatls29964	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66542		-0.61693			CCDC34	chr11	27338511	27363234	103864	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2183
enhrx-27969	chr11	36521018	36521045	36499468	36499495	4948	hg19	N/A	N/A	N/A	Enhatls30440	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.88643		-0.46355			TRAF6	chr11	36483768	36510272	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2638
enhrx-28369	chr11	47042900	47042928	47021349	47021377	4949	hg19	N/A	N/A	N/A	Enhatls30878	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.85377		-0.45712			CSTPP1	chr11	46936753	47164385	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3038
enhrx-31448	chr11	75946903	75946928	76235859	76235884	4950	hg19	N/A	enh1908	N/A	Enhatls34177	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15002		-0.51545			WNT11	chr11	76186324	76210736	23536	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6117
enhrx-31448	chr11	75946903	75946928	76235859	76235884	4951	hg19	N/A	enh1908	fant39295	Enhatls34177	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15002		-0.51545			WNT11	chr11	76186324	76210736	25138	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6117
enhrx-32126	chr11	92002287	92002316	92269121	92269150	4952	hg19	N/A	enh14179	N/A	Enhatls34896	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.750881		0.44951			FAT3	chr11	92224817	92896473	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6795
enhrx-32335	chr11	94986470	94986498	95253306	95253334	4953	hg19	N/A	enh1956	N/A	Enhatls35112	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29202		-0.54341			SESN3	chr11	95165512	95232541	12881	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32335	chr11	94987567	94987594	95254403	95254430	4954	hg19	N/A	enh1956	fant39616	Enhatls35112	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.21386		-0.52802			SESN3	chr11	95165512	95232541	21811	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32335	chr11	94987596	94987623	95254432	95254459	4955	hg19	N/A	enh1956	fant39616	Enhatls35112	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.65844		-0.41866			SESN3	chr11	95165512	95232541	21811	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32335	chr11	94987625	94987651	95254461	95254487	4956	hg19	N/A	enh1956	fant39616	Enhatls35112	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73147		-0.43304			SESN3	chr11	95165512	95232541	21811	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32335	chr11	94989011	94989039	95255847	95255875	4957	hg19	N/A	enh1956	N/A	Enhatls35112	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81161		-0.44882			SESN3	chr11	95165512	95232541	22063	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32335	chr11	95026539	95026561	95293375	95293397	4958	hg19	N/A	enh47518	N/A	Enhatls35112	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.084636		0.31833			SESN3	chr11	95165512	95232541	54793	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7004
enhrx-32374	chr11	95870479	95870506	96137315	96137342	4959	hg19	N/A	enh14211	N/A	Enhatls35151	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.60331		-0.99849			MAML2	chr11	95976597	96343195	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7043
enhrx-32374	chr11	95968198	95968228	96235034	96235064	4960	hg19	N/A	enh14213	N/A	Enhatls35151	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.07447		-0.69747			MAML2	chr11	95976597	96343195	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7043
enhrx-32374	chr11	95975571	95975599	96242407	96242435	4961	hg19	N/A	enh14213	N/A	Enhatls35151	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.48076		-0.97436			MAML2	chr11	95976597	96343195	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7043
enhrx-32416	chr11	100502345	100502375	100631614	100631644	4962	hg19	N/A	enh14219	N/A	Enhatls35199	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.18487		-0.9161			ARHGAP42	chr11	100687287	100993941	44404	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7085
enhrx-32494	chr11	102150522	102150551	102279791	102279820	4963	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.14164		-0.90759			BIRC3	chr11	102317483	102339403	21216	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7163
enhrx-33034	chr11	111504326	111504354	111633602	111633630	4964	hg19	N/A	enh2003	N/A	Enhatls35851	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.11874		-0.90308			SIK2	chr11	111602448	111730855	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7703
enhrx-33259	chr11	114076368	114076396	114205646	114205674	4965	hg19	N/A	N/A	N/A	Enhatls36092	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.25114		-0.92915			ZBTB16	chr11	114059040	114256765	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7928
enhrx-33259	chr11	114076520	114076548	114205798	114205826	4966	hg19	N/A	N/A	N/A	Enhatls36092	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.972444		0.29624			ZBTB16	chr11	114059040	114256765	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7928
enhrx-33863	chr11	120271662	120271687	120400953	120400978	4967	hg19	N/A	enh29197	N/A	Enhatls36748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.94591		-0.86905			ARHGEF12	chr11	120336412	120489937	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8532
enhrx-33995	chr11	121541523	121541550	121670815	121670842	4968	hg19	N/A	enh29203	N/A	Enhatls36887	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.966705		0.29511			SORL1	chr11	121452313	121633763	34674	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8664
enhrx-33995	chr11	121543725	121543753	121673017	121673045	4969	hg19	N/A	enh29203	N/A	Enhatls36887	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.0055		-0.68389			SORL1	chr11	121452313	121633763	38414	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8664
enhrx-34235	chr11	125218280	125218308	125348384	125348412	4970	hg19	N/A	enh2082	N/A	Enhatls37142	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99781		-0.48548			PKNOX2	chr11	125164734	125433389	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8904
enhrx-34398	chr11	128292691	128292718	128422796	128422823	4971	hg19	N/A	enh14381	N/A	Enhatls37315	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.82568		-0.45159			ETS1	chr11	128458760	128587558	33891	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9067
enhrx-34398	chr11	128321879	128321908	128451984	128452013	4972	hg19	N/A	enh2102	N/A	Enhatls37315	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.306582		0.36203			ETS1	chr11	128458760	128587558	5314	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9067
enhrx-34493	chr11	129907122	129907148	130037227	130037253	4973	hg19	N/A	enh14399	N/A	Enhatls37425	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.495392		0.5961			APLP2	chr11	130068146	130144811	26012	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9162
enhrx-34547	chr11	130392522	130392545	130522627	130522650	4974	hg19	N/A	enh14405	fant40485	Enhatls37482	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30203		-0.54538			ADAMTS15	chr11	130448644	130476645	45703	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	9216
enhrx-34845	chr12	1427748	1427777	1318582	1318611	4975	hg19	N/A	enh2145	N/A	Enhatls37809	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.41161		-0.76385			ERC1	chr12	990508	1495933	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	155
enhrx-34845	chr12	1459420	1459444	1350254	1350278	4976	hg19	N/A	enh2146	N/A	Enhatls37809	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.63183		-0.80721			ERC1	chr12	990508	1495933	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	155
enhrx-35010	chr12	3246872	3246900	3137706	3137734	4977	hg19	N/A	enh14459	N/A	Enhatls37998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.15797		-0.71391			TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	320
enhrx-35010	chr12	3247025	3247054	3137859	3137888	4978	hg19	N/A	enh14459	N/A	Enhatls37998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.24314		-0.73068			TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	320
enhrx-35010	chr12	3274184	3274210	3165018	3165044	4979	hg19	N/A	enh29336	N/A	Enhatls37998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.54876		-0.59396			TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	320
enhrx-35010	chr12	3274268	3274294	3165102	3165128	4980	hg19	N/A	enh29336	N/A	Enhatls37998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.91789		-0.66664			TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	320
enhrx-35010	chr12	3274324	3274350	3165158	3165184	4981	hg19	N/A	enh29336	N/A	Enhatls37998	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.5447		-0.98695			TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	320
enhrx-35058	chr12	4154394	4154421	4045228	4045255	4982	hg19	N/A	N/A	N/A	Enhatls38048	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67799		-0.42251			PARP11	chr12	3808860	3873448	167502	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	368
enhrx-35058	chr12	4154481	4154508	4045315	4045342	4983	hg19	N/A	N/A	N/A	Enhatls38048	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.8847		-0.46321			PARP11	chr12	3808860	3873448	167502	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	368
enhrx-35069	chr12	4526916	4526944	4417750	4417778	4984	hg19	N/A	N/A	N/A	Enhatls38063	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26282		-0.53766			FGF6	chr12	4428155	4445815	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	379
enhrx-35207	chr12	6404433	6404468	6295267	6295302	4985	hg19	N/A	enh14493	fant40789	Enhatls38212	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7076		-0.42834			PLEKHG6	chr12	6310435	6328506	14935	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	517
enhrx-36077	chr12	12537931	12537960	12384997	12385026	4986	hg19	N/A	enh14532	N/A	Enhatls39124	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40242		-0.76204			BORCS5	chr12	12357077	12471233	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1387
enhrx-36090	chr12	12860454	12860483	12707520	12707549	4987	hg19	N/A	enh43697	N/A	Enhatls39141	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57791		-0.5997			GPR19	chr12	12660889	12696207	5048	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1400
enhrx-36657	chr12	23070163	23070191	22917229	22917257	4988	hg19	N/A	N/A	N/A	Enhatls39739	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06617		-0.49894			ETNK1	chr12	22625074	22690665	126277	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1967
enhrx-36681	chr12	24167825	24167853	24014891	24014919	4989	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.54069		-0.59237			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24167916	24167944	24014982	24015010	4990	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.65519		-0.41802			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24167946	24167974	24015012	24015040	4991	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06774		-0.49925			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168127	24168156	24015193	24015222	4992	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6624		-0.41944			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168158	24168186	24015224	24015252	4993	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95078		-0.47622			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168551	24168579	24015617	24015645	4994	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.34342		-0.55353			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168581	24168609	24015647	24015675	4995	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.8832		-0.65981			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168793	24168821	24015859	24015887	4996	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83625		-0.45367			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168823	24168851	24015889	24015917	4997	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68144		-0.42319			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24168944	24168972	24016010	24016038	4998	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15611		-0.51665			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36681	chr12	24169043	24169070	24016109	24016136	4999	hg19	N/A	N/A	N/A	Enhatls39762	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.91525		-0.66612			SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1991
enhrx-36825	chr12	26898003	26898030	26745070	26745097	5000	hg19	N/A	enh2236	N/A	Enhatls39916	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5317		-0.5906			ITPR2	chr12	26335351	26833194	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2135
enhrx-36825	chr12	26899303	26899328	26746370	26746395	5001	hg19	N/A	enh2236	N/A	Enhatls39916	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71821		-0.43043			ITPR2	chr12	26335351	26833194	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2135
enhrx-36860	chr12	27347037	27347061	27194104	27194128	5002	hg19	N/A	enh14598	fant41311	Enhatls39953	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66298		-0.61645			STK38L	chr12	27243967	27325959	49783	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2170
enhrx-37104	chr12	31515642	31515663	31362708	31362729	5003	hg19	N/A	enh14619	N/A	Enhatls40208	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79973		-0.44648			DENND5B	chr12	31382225	31591136	16504	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2414
enhrx-37156	chr12	32609402	32609440	32456468	32456506	5004	hg19	N/A	enh14631	N/A	Enhatls40264	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05027		-0.49581			FGD4	chr12	32399557	32646050	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2466
enhrx-37715	chr12	46825854	46825884	46432071	46432101	5005	hg19	N/A	enh14676	fant41536	Enhatls40838	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.37146		-0.55905			SLC38A2	chr12	46358187	46372773	58871	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3025
enhrx-39043	chr12	56131628	56131651	55737844	55737867	5006	hg19	N/A	N/A	N/A	Enhatls42236	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39609		-0.5639			GDF11	chr12	55743121	55757264	4846	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4353
enhrx-39044	chr12	56132241	56132270	55738457	55738486	5007	hg19	N/A	N/A	fant41915	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46679		-0.57782			GDF11	chr12	55743121	55757264	4344	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4354
enhrx-39765	chr12	64433451	64433480	64039671	64039700	5008	hg19	N/A	enh51248	N/A	Enhatls42987	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.91452		-0.86287			SRGAP1	chr12	63843760	64162217	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5075
enhrx-39897	chr12	66320177	66320207	65926397	65926427	5009	hg19	N/A	enh43759	N/A	Enhatls43138	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.4356		-0.57168			HMGA2	chr12	65824459	65966291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5207
enhrx-39897	chr12	66330181	66330209	65936401	65936429	5010	hg19	N/A	enh43759	N/A	Enhatls43138	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.134764		0.3282			HMGA2	chr12	65824459	65966291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5207
enhrx-39897	chr12	66330968	66331000	65937188	65937220	5011	hg19	N/A	enh43759	N/A	Enhatls43138	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40435		-0.76242			HMGA2	chr12	65824459	65966291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5207
enhrx-40043	chr12	69181420	69181444	68787640	68787664	5012	hg19	N/A	N/A	fant42202	Enhatls43298	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.70034		-0.8207			SLC35E3	chr12	68746175	68781468	5699	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5353
enhrx-40123	chr12	70382445	70382473	69988665	69988693	5013	hg19	N/A	enh14827	N/A	Enhatls43381	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06784		-0.49927			MYRFL	chr12	69825226	69959097	16989	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5433
enhrx-40358	chr12	76034701	76034724	75640921	75640944	5014	hg19	N/A	enh2465	N/A	Enhatls43628	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.70666		-0.62505			KRR1	chr12	75490862	75511609	108957	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5668
enhrx-40358	chr12	76042586	76042617	75648806	75648837	5015	hg19	N/A	enh2465	N/A	Enhatls43628	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.31346		-0.54763			KRR1	chr12	75490862	75511609	129609	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5668
enhrx-40358	chr12	76347357	76347387	75953577	75953607	5016	hg19	N/A	enh2469	N/A	Enhatls43628	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99603		-0.48513			PHLDA1	chr12	76025446	76031776	71390	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5668
enhrx-40476	chr12	79802848	79802875	79409068	79409095	5017	hg19	N/A	enh14845	N/A	Enhatls43748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.41935		-0.56848			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79802993	79803016	79409213	79409236	5018	hg19	N/A	enh14845	N/A	Enhatls43748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.25782		-0.73357			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79803501	79803528	79409721	79409748	5019	hg19	N/A	enh14845	fant42406	Enhatls43748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.95296		-0.87044			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79803530	79803557	79409750	79409777	5020	hg19	N/A	enh14845	fant42406	Enhatls43748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00568		-0.48703			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79803559	79803586	79409779	79409806	5021	hg19	N/A	enh14845	fant42406	Enhatls43748	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.052		-0.49615			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79814327	79814357	79420547	79420577	5022	hg19	N/A	enh14845	N/A	Enhatls43751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97282		-0.48056			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40476	chr12	79814741	79814775	79420961	79420995	5023	hg19	N/A	enh14845	N/A	Enhatls43751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.16957		-0.5193			SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5786
enhrx-40511	chr12	80580687	80580714	80186907	80186934	5024	hg19	N/A	enh29769	N/A	Enhatls43786	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.20851		-0.72386			OTOGL	chr12	80099536	80380880	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5821
enhrx-40511	chr12	80581525	80581553	80187745	80187773	5025	hg19	N/A	enh29769	N/A	Enhatls43786	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91837		-0.46984			OTOGL	chr12	80099536	80380880	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5821
enhrx-40832	chr12	89453982	89454010	89060205	89060233	5026	hg19	N/A	enh29832	N/A	Enhatls44126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.711		-0.42901			DUSP6	chr12	89347234	89352501	282354	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6142
enhrx-40832	chr12	89454103	89454132	89060326	89060355	5027	hg19	N/A	enh29832	N/A	Enhatls44126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01137		-0.48815			DUSP6	chr12	89347234	89352501	282354	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6142
enhrx-40832	chr12	89554475	89554505	89160698	89160728	5028	hg19	N/A	enh2489	N/A	Enhatls44126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.71121		-0.42905			DUSP6	chr12	89347234	89352501	183268	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6142
enhrx-40832	chr12	89646149	89646178	89252372	89252401	5029	hg19	N/A	enh14865	N/A	Enhatls44126	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.01221		-0.68521			DUSP6	chr12	89347234	89352501	88897	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6142
enhrx-40832	chr12	89647482	89647512	89253705	89253735	5030	hg19	N/A	enh14865	N/A	Enhatls44126	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.173161		0.33576			DUSP6	chr12	89347234	89352501	88897	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6142
enhrx-40888	chr12	91668739	91668768	91274962	91274991	5031	hg19	N/A	enh2498	N/A	Enhatls44185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.25533		-0.73308			DCN	chr12	91140483	91182824	84445	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6198
enhrx-40888	chr12	91720016	91720042	91326239	91326265	5032	hg19	N/A	enh2500	N/A	Enhatls44185	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6882		-0.42452			DCN	chr12	91140483	91182824	141265	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6198
enhrx-40889	chr12	92757481	92757510	92363705	92363734	5033	hg19	N/A	enh2505	N/A	Enhatls44191	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67086		-0.618			BTG1	chr12	92140277	92145846	217192	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6199
enhrx-40889	chr12	92757519	92757548	92363743	92363772	5034	hg19	N/A	enh2505	N/A	Enhatls44191	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36318		-0.55742			BTG1	chr12	92140277	92145846	217192	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6199
enhrx-40889	chr12	92759920	92759947	92366144	92366171	5035	hg19	N/A	enh2505	N/A	Enhatls44191	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.480432		0.39626			BTG1	chr12	92140277	92145846	217192	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6199
enhrx-40891	chr12	92968910	92968937	92575134	92575161	5036	hg19	N/A	enh14885	N/A	Enhatls44193	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68556		-0.424			PLEKHG7	chr12	92702842	92772455	126178	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6201
enhrx-41877	chr12	107134072	107134100	106740294	106740322	5037	hg19	N/A	enh51386	N/A	Enhatls45247	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.74295		-0.4353			RFX4	chr12	106583003	106762803	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7187
enhrx-41901	chr12	107421562	107421590	107027784	107027812	5038	hg19	N/A	enh14964	N/A	Enhatls45273	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.22593		-0.72729			CRY1	chr12	106991363	107093549	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7211
enhrx-41901	chr12	107421710	107421738	107027932	107027960	5039	hg19	N/A	enh14964	N/A	Enhatls45273	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.78327		-0.44324			CRY1	chr12	106991363	107093549	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7211
enhrx-42832	chr12	116621824	116621855	116184019	116184050	5040	hg19	N/A	enh30008	N/A	Enhatls46253	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20137		-0.52556			MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8142
enhrx-45302	chr13	34116493	34116517	33542356	33542380	5041	hg19	N/A	enh2761	fant44110	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.10868		-0.9011			STARD13	chr13	33103136	33350630	191676	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45302	chr13	34116840	34116868	33542703	33542731	5042	hg19	N/A	enh2761	fant44110	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.32153		-0.54922			STARD13	chr13	33103136	33350630	191676	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45302	chr13	34116870	34116899	33542733	33542762	5043	hg19	N/A	enh2761	fant44110	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.77454		-0.83531			STARD13	chr13	33103136	33350630	191676	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45302	chr13	34117021	34117049	33542884	33542912	5044	hg19	N/A	enh2761	fant44110	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.04524		-0.49482			STARD13	chr13	33103136	33350630	191676	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45302	chr13	34117074	34117110	33542937	33542973	5045	hg19	N/A	enh2761	fant44110	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46801		-0.57806			STARD13	chr13	33103136	33350630	191676	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45302	chr13	34118171	34118212	33544034	33544075	5046	hg19	N/A	enh2761	N/A	Enhatls48899	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73556		-0.63074			STARD13	chr13	33103136	33350630	192522	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-45312	chr13	34730752	34730773	34156615	34156636	5047	hg19	N/A	enh30202	N/A	Enhatls48912	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.482616		0.39669			RFC3	chr13	33818068	33966558	190050	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	934
enhrx-45987	chr13	47229526	47229554	46655391	46655419	5048	hg19	N/A	enh15301	N/A	Enhatls49640	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.96563		-0.67604			LRCH1	chr13	46553167	46753040	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1609
enhrx-46088	chr13	49528332	49528359	48954196	48954223	5049	hg19	N/A	enh51544	N/A	Enhatls49751	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.77444		-0.4415			FNDC3A	chr13	48975911	49209779	18093	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1710
enhrx-46221	chr13	51565127	51565153	50990991	50991017	5050	hg19	N/A	enh15342	N/A	Enhatls49903	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17094		-0.51957			RNASEH2B	chr13	50909746	51024120	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1843
enhrx-46419	chr13	53507383	53507412	52933248	52933277	5051	hg19	N/A	N/A	N/A	Enhatls50120	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.5803		-0.60017			OLFM4	chr13	53028812	53052057	75862	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2041
enhrx-46419	chr13	53508288	53508316	52934153	52934181	5052	hg19	N/A	N/A	N/A	Enhatls50120	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.49432		-0.97703			OLFM4	chr13	53028812	53052057	75862	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2041
enhrx-46592	chr13	72333075	72333102	71758943	71758970	5053	hg19	N/A	enh30423	N/A	Enhatls50308	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69277		-0.42542			DACH1	chr13	71437965	71867204	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2214
enhrx-46634	chr13	74250820	74250857	73676683	73676720	5054	hg19	N/A	enh30437	N/A	Enhatls50350	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1906		-0.52344			KLF12	chr13	73686088	74134404	6051	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2256
enhrx-46634	chr13	74251586	74251607	73677449	73677470	5055	hg19	N/A	enh30437	N/A	Enhatls50350	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39401		-0.56349			KLF12	chr13	73686088	74134404	6051	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2256
enhrx-46635	chr13	74337688	74337709	73763551	73763572	5056	hg19	N/A	enh2926	N/A	Enhatls50352	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.77586		-0.83557			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74338102	74338131	73763965	73763994	5057	hg19	N/A	enh2926	N/A	Enhatls50352	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.383454		0.57406			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340179	74340206	73766042	73766069	5058	hg19	N/A	enh2926	fant44749	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.29449		-0.74079			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340208	74340236	73766071	73766099	5059	hg19	N/A	enh2926	fant44749	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.27976		-0.73789			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340386	74340413	73766249	73766276	5060	hg19	N/A	enh2926	fant44749	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97947		-0.48187			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340386	74340413	73766249	73766276	5061	hg19	N/A	enh2926	N/A	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97947		-0.48187			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340415	74340443	73766278	73766306	5062	hg19	N/A	enh2926	N/A	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.21041		-0.52734			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74340504	74340532	73766367	73766395	5063	hg19	N/A	enh2926	N/A	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17709		-0.52078			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74341535	74341563	73767398	73767426	5064	hg19	N/A	enh2926	N/A	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.44012		-0.57257			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46635	chr13	74341595	74341624	73767458	73767487	5065	hg19	N/A	enh2926	N/A	Enhatls50353	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20477		-0.52623			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2257
enhrx-46638	chr13	74601715	74601738	74027578	74027601	5066	hg19	N/A	enh2937	N/A	Enhatls50357	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.42418		-0.56943			KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2260
enhrx-46904	chr13	80121823	80121850	79547688	79547715	5067	hg19	N/A	N/A	N/A	Enhatls50639	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.51524		-0.58736			NDFIP2	chr13	79481154	79556077	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2526
enhrx-46904	chr13	80122087	80122115	79547952	79547980	5068	hg19	N/A	N/A	N/A	Enhatls50639	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80907		-0.44832			NDFIP2	chr13	79481154	79556077	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2526
enhrx-46916	chr13	80644480	80644509	80070345	80070374	5069	hg19	N/A	enh68527	N/A	Enhatls50656	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17201		-0.51978			SPRY2	chr13	80335975	80341126	263476	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2538
enhrx-46916	chr13	80809725	80809754	80235590	80235619	5070	hg19	N/A	enh30492	N/A	Enhatls50656	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.74414		-0.63243			SPRY2	chr13	80335975	80341126	93816	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2538
enhrx-46916	chr13	80809756	80809784	80235621	80235649	5071	hg19	N/A	enh30492	N/A	Enhatls50656	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.52479		-0.58924			SPRY2	chr13	80335975	80341126	93816	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2538
enhrx-46919	chr13	80932185	80932221	80358050	80358086	5072	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75364		-0.6343			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933283	80933311	80359148	80359176	5073	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.76373		-0.83318			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933374	80933402	80359239	80359267	5074	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86883		-0.65698			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933464	80933492	80359329	80359357	5075	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26617		-0.53832			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933494	80933523	80359359	80359388	5076	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80217		-0.44696			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933892	80933920	80359757	80359785	5077	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06281		-0.49828			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80933953	80933981	80359818	80359846	5078	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.86586		-0.85329			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80934167	80934196	80360032	80360061	5079	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80588		-0.44769			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80934198	80934226	80360063	80360091	5080	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.20729		-0.72362			SPRY2	chr13	80335975	80341126	16105	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80936168	80936197	80362033	80362062	5081	hg19	N/A	enh51611	fant44855	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07104		-0.4999			SPRY2	chr13	80335975	80341126	20853	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80936199	80936227	80362064	80362092	5082	hg19	N/A	enh51611	fant44855	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17694		-0.52075			SPRY2	chr13	80335975	80341126	20853	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80936351	80936379	80362216	80362244	5083	hg19	N/A	enh51611	fant44855	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.20363		-0.7229			SPRY2	chr13	80335975	80341126	20853	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80936381	80936410	80362246	80362275	5084	hg19	N/A	enh51611	fant44855	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97373		-0.48074			SPRY2	chr13	80335975	80341126	20853	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	80936381	80936410	80362246	80362275	5085	hg19	N/A	enh51611	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97373		-0.48074			SPRY2	chr13	80335975	80341126	21145	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81136944	81136972	80562809	80562837	5086	hg19	N/A	enh103897	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.78597		-0.44377			SPRY2	chr13	80335975	80341126	219465	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81137033	81137060	80562898	80562925	5087	hg19	N/A	enh103897	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9233		-0.47081			SPRY2	chr13	80335975	80341126	219465	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81431606	81431641	80857471	80857506	5088	hg19	N/A	N/A	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.27074		-0.53922			SPRY2	chr13	80335975	80341126	501815	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81436831	81436865	80862696	80862730	5089	hg19	N/A	N/A	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38487		-0.56169			SPRY2	chr13	80335975	80341126	516653	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81436831	81436865	80862696	80862730	5090	hg19	N/A	N/A	fant44859	Enhatls50658	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38487		-0.56169			SPRY2	chr13	80335975	80341126	521600	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-46919	chr13	81440618	81440647	80866483	80866512	5091	hg19	N/A	N/A	N/A	Enhatls50658	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.279004		0.3566			SPRY2	chr13	80335975	80341126	521988	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2541
enhrx-47049	chr13	95293118	95293144	94640864	94640890	5092	hg19	N/A	enh30580	N/A	Enhatls50804	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.63688		-0.61131			GPR180	chr13	94601856	94634661	4071	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2671
enhrx-47056	chr13	95600591	95600619	94948337	94948365	5093	hg19	N/A	enh68576	N/A	Enhatls50812	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7368		-0.43409			ABCC4	chr13	95019834	95301451	68699	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2678
enhrx-47167	chr13	97792880	97792907	97140626	97140653	5094	hg19	N/A	enh15421	N/A	Enhatls50929	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.202415		0.34152			MBNL2	chr13	97221433	97394120	75093	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2789
enhrx-47549	chr13	106571630	106571665	105919281	105919316	5095	hg19	N/A	enh15468	N/A	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.98879		-0.6806			DAOA	chr13	105466044	105491034	421623	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106632371	106632399	105980022	105980050	5096	hg19	N/A	enh51701	N/A	Enhatls51339	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.453209		0.3909			DAOA	chr13	105466044	105491034	486100	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106741877	106741906	106089528	106089557	5097	hg19	N/A	enh115559	N/A	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39294		-0.56328			EFNB2	chr13	106489744	106535662	397465	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106742169	106742195	106089820	106089846	5098	hg19	N/A	enh115559	N/A	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.09176		-0.50398			EFNB2	chr13	106489744	106535662	397465	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106753072	106753098	106100723	106100749	5099	hg19	N/A	enh30660	fant45160	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.06152		-0.69492			EFNB2	chr13	106489744	106535662	388822	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106753129	106753156	106100780	106100807	5100	hg19	N/A	enh30660	fant45160	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.86281		-0.4589			EFNB2	chr13	106489744	106535662	388822	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47549	chr13	106761888	106761916	106109539	106109567	5101	hg19	N/A	enh30660	N/A	Enhatls51339	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68302		-0.4235			EFNB2	chr13	106489744	106535662	376959	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3171
enhrx-47562	chr13	107571191	107571212	106918843	106918864	5102	hg19	N/A	enh3013	N/A	Enhatls51358	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.30599		-0.54616			NALF1	chr13	107163509	107867496	243972	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3184
enhrx-47592	chr13	109568238	109568263	108915890	108915915	5103	hg19	N/A	enh15478	fant45203	Enhatls51390	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.82627		-0.6486			MYO16	chr13	108596151	109208005	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3214
enhrx-47592	chr13	109568265	109568290	108915917	108915942	5104	hg19	N/A	enh15478	fant45203	Enhatls51390	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86009		-0.65526			MYO16	chr13	108596151	109208005	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3214
enhrx-48193	chr14	21099369	21099399	20631210	20631240	5105	hg19	N/A	enh15525	N/A	Enhatls52041	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.3003		-0.54504			OR6S1	chr14	20640695	20641691	5580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	150
enhrx-48781	chr14	26099066	26099092	25629860	25629886	5106	hg19	N/A	N/A	N/A	Enhatls52662	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.04481		-0.69163			STXBP6	chr14	24809453	25050147	540248	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	738
enhrx-48782	chr14	26849981	26850010	26380775	26380804	5107	hg19	N/A	enh51755	N/A	Enhatls52663	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84265		-0.45493			NOVA1	chr14	26443089	26598033	57621	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	739
enhrx-48984	chr14	32431773	32431800	31962567	31962594	5108	hg19	N/A	enh3065	N/A	Enhatls52879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.84402		-0.4552			NUBPL	chr14	31489955	31861224	98821	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	941
enhrx-48984	chr14	32432046	32432073	31962840	31962867	5109	hg19	N/A	enh3065	N/A	Enhatls52879	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.933213		0.48541			NUBPL	chr14	31489955	31861224	98821	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	941
enhrx-48984	chr14	32432338	32432365	31963132	31963159	5110	hg19	N/A	enh3065	N/A	Enhatls52879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97861		-0.4817			NUBPL	chr14	31489955	31861224	98821	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	941
enhrx-48984	chr14	32433054	32433084	31963848	31963878	5111	hg19	N/A	enh3065	N/A	Enhatls52879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11045		-0.50766			NUBPL	chr14	31489955	31861224	98821	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	941
enhrx-48984	chr14	32461450	32461475	31992244	31992269	5112	hg19	N/A	enh43983	N/A	Enhatls52879	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.18001		-0.71825			ARHGAP5	chr14	32076113	32159728	78910	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	941
enhrx-48991	chr14	32672707	32672736	32203501	32203530	5113	hg19	N/A	enh3067	fant45693	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49442		-0.58326			ARHGAP5	chr14	32076113	32159728	43427	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	948
enhrx-49006	chr14	33419327	33419355	32950121	32950149	5114	hg19	N/A	enh75422	N/A	Enhatls52903	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.179712		0.33705			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	963
enhrx-49006	chr14	33419357	33419386	32950151	32950180	5115	hg19	N/A	enh75422	N/A	Enhatls52903	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.87861		-0.8558			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	963
enhrx-49006	chr14	33496247	33496275	33027041	33027069	5116	hg19	N/A	enh30784	N/A	Enhatls52903	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73965		-0.43465			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	963
enhrx-49008	chr14	33819077	33819114	33349871	33349908	5117	hg19	hs527	N/A	N/A	Enhatls52905	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.129787		0.32722			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	965
enhrx-49008	chr14	33819160	33819187	33349954	33349981	5118	hg19	hs527	N/A	N/A	Enhatls52905	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.0457		-0.49491			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	965
enhrx-49008	chr14	33819218	33819245	33350012	33350039	5119	hg19	hs527	N/A	N/A	Enhatls52905	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.69595		-0.62294			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	965
enhrx-49012	chr14	34257297	34257324	33788091	33788118	5120	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.63002		-0.60996			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34257909	34257936	33788703	33788730	5121	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91964		-0.47009			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34257997	34258025	33788791	33788819	5122	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.83691		-0.4538			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34259709	34259738	33790503	33790532	5123	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7718		-0.44098			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34261420	34261448	33792214	33792242	5124	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17506		-0.52038			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34261728	34261756	33792522	33792550	5125	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92467		-0.47108			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262136	34262164	33792930	33792958	5126	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95164		-0.47639			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262166	34262194	33792960	33792988	5127	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.03552		-0.6898			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262439	34262468	33793233	33793262	5128	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99522		-0.48497			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262470	34262498	33793264	33793292	5129	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.3754		-0.75672			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262500	34262528	33793294	33793322	5130	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17206		-0.51979			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262561	34262589	33793355	33793383	5131	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.14443		-0.51435			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262591	34262620	33793385	33793414	5132	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25581		-0.53628			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262913	34262940	33793707	33793734	5133	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.18128		-0.7185			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-49012	chr14	34262942	34262969	33793736	33793763	5134	hg19	N/A	enh3080	N/A	Enhatls52911	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.01736		-0.88312			NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	969
enhrx-50282	chr14	61612572	61612601	61145854	61145883	5135	hg19	N/A	enh15651	N/A	Enhatls54241	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.19863		-0.91881			PRKCH	chr14	61187558	61550976	37074	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2239
enhrx-50282	chr14	61620298	61620327	61153580	61153609	5136	hg19	N/A	enh75498	N/A	Enhatls54241	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05906		-0.49754			PRKCH	chr14	61187558	61550976	30502	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2239
enhrx-50345	chr14	63691271	63691300	63224553	63224582	5137	hg19	N/A	enh75511	N/A	Enhatls54310	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.078541		0.31713			RHOJ	chr14	63204442	63293508	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2302
enhrx-50351	chr14	63829698	63829731	63362980	63363013	5138	hg19	N/A	enh51852	fant46293	Enhatls54316	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25525		-0.53617			PPP2R5E	chr14	63371363	63543377	8107	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2308
enhrx-50782	chr14	68407786	68407814	67941069	67941097	5139	hg19	N/A	enh15706	fant46397	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95585		-0.47722			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68408031	68408060	67941314	67941343	5140	hg19	N/A	enh15706	N/A	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.19273		-0.52386			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68408499	68408526	67941782	67941809	5141	hg19	N/A	enh15706	fant46398	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17333		-0.52004			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68408499	68408526	67941782	67941809	5142	hg19	N/A	enh15706	N/A	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17333		-0.52004			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68408558	68408586	67941841	67941869	5143	hg19	N/A	enh15706	N/A	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.2436		-0.73077			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68666378	68666399	68199661	68199682	5144	hg19	N/A	enh30989	N/A	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36084		-0.55696			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68666578	68666606	68199861	68199889	5145	hg19	N/A	enh30989	fant46415	Enhatls54763	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79099		-0.44476			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68758745	68758772	68292028	68292055	5146	hg19	N/A	enh15709	N/A	Enhatls54764	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.6625		-0.41946			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68826562	68826590	68359845	68359873	5147	hg19	N/A	enh15712	N/A	Enhatls54764	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.434468		0.38721			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68831448	68831476	68364731	68364759	5148	hg19	N/A	enh15712	N/A	Enhatls54764	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.810456		0.46124			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50782	chr14	68836688	68836716	68369971	68369999	5149	hg19	N/A	enh15712	N/A	Enhatls54764	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10487		-0.50656			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2739
enhrx-50784	chr14	68989276	68989304	68522559	68522587	5150	hg19	N/A	enh15715	N/A	Enhatls54768	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98663		-0.48328			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2741
enhrx-50784	chr14	68994333	68994364	68527616	68527647	5151	hg19	N/A	enh15715	N/A	Enhatls54768	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67093		-0.42112			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2741
enhrx-50785	chr14	69184812	69184850	68718095	68718133	5152	hg19	N/A	enh15721	N/A	Enhatls54769	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.01624		-0.48911			RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2742
enhrx-50785	chr14	69229890	69229925	68763173	68763208	5153	hg19	N/A	enh15722	N/A	Enhatls54769	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.90027		-0.66317			ZFP36L1	chr14	68787661	68796253	21924	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2742
enhrx-50785	chr14	69230002	69230028	68763285	68763311	5154	hg19	N/A	enh15722	N/A	Enhatls54769	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.08201		-0.50206			ZFP36L1	chr14	68787661	68796253	21924	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2742
enhrx-50857	chr14	70099379	70099410	69632662	69632693	5155	hg19	N/A	enh3308	fant46531	Enhatls54848	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.29353		0.35946			SUSD6	chr14	69611595	69715144	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2814
enhrx-51638	chr14	80040101	80040130	79573758	79573787	5156	hg19	N/A	enh75539	N/A	Enhatls55694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.29104		-0.74011			NRXN3	chr14	78170372	79868291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3595
enhrx-51638	chr14	80050079	80050104	79583736	79583761	5157	hg19	N/A	enh3345	N/A	Enhatls55694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10832		-0.50724			NRXN3	chr14	78170372	79868291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3595
enhrx-51638	chr14	80052359	80052389	79586016	79586046	5158	hg19	N/A	enh3345	N/A	Enhatls55694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.408		-0.76314			NRXN3	chr14	78170372	79868291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3595
enhrx-51638	chr14	80052359	80052389	79586016	79586046	5159	hg19	N/A	enh3345	fant46805	Enhatls55694	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.408		-0.76314			NRXN3	chr14	78170372	79868291	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3595
enhrx-51703	chr14	81781562	81781598	81315218	81315254	5160	hg19	N/A	enh58594	N/A	Enhatls55759	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98734		-0.48342			STON2	chr14	81260651	81436465	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3660
enhrx-51736	chr14	85986322	85986350	85519978	85520006	5161	hg19	N/A	enh31087	N/A	Enhatls55794	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7365		-0.43403			FLRT2	chr14	85530143	85654428	7993	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3693
enhrx-51736	chr14	85987764	85987793	85521420	85521449	5162	hg19	N/A	enh31087	N/A	Enhatls55794	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.056273		0.50964			FLRT2	chr14	85530143	85654428	7993	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3693
enhrx-51881	chr14	89507117	89507137	89040773	89040793	5163	hg19	N/A	enh15830	N/A	Enhatls55943	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46161		-0.5768			FOXN3	chr14	89124870	89619149	83441	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3838
enhrx-51881	chr14	89507205	89507226	89040861	89040882	5164	hg19	N/A	enh15830	N/A	Enhatls55943	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.82909		-0.45226			FOXN3	chr14	89124870	89619149	83441	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3838
enhrx-51881	chr14	89507461	89507488	89041117	89041144	5165	hg19	N/A	enh15830	N/A	Enhatls55943	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67065		-0.61796			FOXN3	chr14	89124870	89619149	83441	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3838
enhrx-51881	chr14	89507571	89507597	89041227	89041253	5166	hg19	N/A	enh15830	N/A	Enhatls55943	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.63036		-0.80692			FOXN3	chr14	89124870	89619149	83441	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3838
enhrx-52706	chr14	102438852	102438889	101972515	101972552	5167	hg19	N/A	enh3459	N/A	Enhatls56847	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.00568		-0.48703			DYNC1H1	chr14	101964572	102056443	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4663
enhrx-53634	chr15	25573031	25573054	25327884	25327907	5168	hg19	N/A	enh51951	N/A	Enhatls57788	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.62306		-0.60859			UBE3A	chr15	25333727	25439051	3800	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	336
enhrx-54363	chr15	35989845	35989875	35697644	35697674	5169	hg19	N/A	enh16040	N/A	Enhatls58546	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.2098		-0.52722			DPH6	chr15	35370879	35546192	144900	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1065
enhrx-54363	chr15	35989940	35989967	35697739	35697766	5170	hg19	N/A	enh16040	N/A	Enhatls58546	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99029		-0.484			DPH6	chr15	35370879	35546192	144900	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1065
enhrx-54363	chr15	35990206	35990233	35698005	35698032	5171	hg19	N/A	enh16040	fant47784	Enhatls58546	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69338		-0.42554			DPH6	chr15	35370879	35546192	151600	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1065
enhrx-54408	chr15	38455601	38455637	38163400	38163436	5172	hg19	N/A	enh68906	N/A	Enhatls58602	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.55258		0.60736			SPRED1	chr15	38252835	38357249	86177	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1110
enhrx-54408	chr15	38456057	38456077	38163856	38163876	5173	hg19	N/A	enh68906	N/A	Enhatls58602	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.29604		-0.93799			SPRED1	chr15	38252835	38357249	86177	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1110
enhrx-54408	chr15	38467376	38467401	38175175	38175200	5174	hg19	N/A	enh104090	N/A	Enhatls58602	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.190734		0.33922			SPRED1	chr15	38252835	38357249	72962	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1110
enhrx-54408	chr15	38486989	38487027	38194788	38194826	5175	hg19	N/A	enh44097	N/A	Enhatls58602	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.025924		0.30677			SPRED1	chr15	38252835	38357249	55042	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1110
enhrx-54408	chr15	38499900	38499926	38207699	38207725	5176	hg19	N/A	enh16045	N/A	Enhatls58602	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.845676		0.27128			SPRED1	chr15	38252835	38357249	40742	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1110
enhrx-54441	chr15	39470037	39470067	39177836	39177866	5177	hg19	N/A	N/A	N/A	Enhatls58634	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.87987		-0.46226			THBS1	chr15	39581078	39599466	401075	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1143
enhrx-54445	chr15	39724631	39724652	39432430	39432451	5178	hg19	N/A	enh31310	N/A	Enhatls58636	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.946034		0.29104			THBS1	chr15	39581078	39599466	147483	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1147
enhrx-56147	chr15	53852318	53852345	53560121	53560148	5179	hg19	N/A	enh52008	N/A	Enhatls60408	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.26668		-0.53842			WDR72	chr15	53513740	53762878	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2849
enhrx-56265	chr15	56009788	56009815	55717590	55717617	5180	hg19	N/A	N/A	N/A	Enhatls60526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18552		-0.52244			PRTG	chr15	55611543	55743152	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2967
enhrx-56287	chr15	56334591	56334613	56042393	56042415	5181	hg19	N/A	enh16155	N/A	Enhatls60551	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.0761		-0.69779			RFX7	chr15	56087279	56245082	38030	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2989
enhrx-lit73	chr15	56760322	56760349	56468124	56468151	5182	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.84146		-0.65159								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-56336	chr15	57219964	57219988	56927766	56927790	5183	hg19	N/A	enh47858	N/A	Enhatls60603	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.72723		-0.6291			TCF12	chr15	56918622	57299281	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3038
enhrx-56651	chr15	62881699	62881726	62589500	62589527	5184	hg19	N/A	N/A	N/A	Enhatls60946	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.60209		-0.60446			TLN2	chr15	62390549	62844631	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3353
enhrx-56955	chr15	65375788	65375817	65083450	65083479	5185	hg19	N/A	enh16239	N/A	Enhatls61283	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07145		-0.49998			KBTBD13	chr15	65076745	65079948	609	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3657
enhrx-57181	chr15	66937797	66937819	66645459	66645481	5186	hg19	N/A	enh16251	N/A	Enhatls61515	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.08651		-0.69984			SMAD6	chr15	66702235	66782849	40721	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3883
enhrx-57185	chr15	67037587	67037612	66745249	66745274	5187	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.52098		-0.58849			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67058294	67058322	66765956	66765984	5188	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.94214		-0.47452			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67058542	67058568	66766204	66766230	5189	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.46699		-0.57786			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67062970	67063000	66770632	66770662	5190	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.45252		-0.57501			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67065442	67065470	66773104	66773132	5191	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9913		-0.4842			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67065626	67065654	66773288	66773316	5192	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.57522		-0.59917			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57185	chr15	67066839	67066865	66774501	66774527	5193	hg19	N/A	enh16253	N/A	Enhatls61523	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.86802		-0.65682			SMAD6	chr15	66702235	66782849	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3887
enhrx-57186	chr15	67134711	67134738	66842373	66842400	5194	hg19	N/A	enh16256	fant48585	Enhatls61524	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.76705		-0.63694			SMAD6	chr15	66702235	66782849	59262	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3888
enhrx-57186	chr15	67134799	67134826	66842461	66842488	5195	hg19	N/A	enh16256	fant48585	Enhatls61524	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.33606		-0.55208			SMAD6	chr15	66702235	66782849	59262	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3888
enhrx-57186	chr15	67142893	67142922	66850555	66850584	5196	hg19	N/A	enh16257	N/A	Enhatls61524	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.95693		-0.87122			SMAD6	chr15	66702235	66782849	64004	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3888
enhrx-58076	chr15	77437233	77437261	77144891	77144919	5197	hg19	N/A	enh16349	N/A	Enhatls62480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.80984		-0.44847			PEAK1	chr15	77100655	77420144	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4778
enhrx-58078	chr15	77479557	77479588	77187215	77187246	5198	hg19	N/A	enh31514	N/A	Enhatls62482	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.104748		0.32229			PEAK1	chr15	77100655	77420144	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4780
enhrx-58747	chr15	85591815	85591844	85048584	85048613	5199	hg19	N/A	enh16388	N/A	Enhatls63259	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.56951		-0.79494			PDE8A	chr15	84980439	85139145	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5449
enhrx-58768	chr15	85987203	85987225	85443972	85443994	5200	hg19	N/A	enh3767	fant49177	Enhatls63282	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.33751		-0.74926			AKAP13	chr15	85380586	85749358	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5470
enhrx-58835	chr15	87100388	87100427	86557157	86557196	5201	hg19	N/A	N/A	N/A	Enhatls63359	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.411664		0.38272			AGBL1	chr15	86079870	87029052	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5537
enhrx-59128	chr15	90945707	90945736	90402475	90402504	5202	hg19	N/A	enh3791	fant49321	Enhatls63671	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.78976		-1.0352			IQGAP1	chr15	90388241	90502239	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5830
enhrx-59310	chr15	93375289	93375317	92832059	92832087	5203	hg19	N/A	enh3814	fant49393	Enhatls63861	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.85636		-0.85142			FAM174B	chr15	92617447	92809798	21753	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6012
enhrx-59393	chr15	96578977	96578999	96035748	96035770	5204	hg19	N/A	enh52161	N/A	Enhatls63955	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.97127		-0.67715			NR2F2	chr15	96325937	96340263	285552	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6095
enhrx-59393	chr15	96581019	96581048	96037790	96037819	5205	hg19	N/A	enh52161	N/A	Enhatls63955	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.14265		-0.514			NR2F2	chr15	96325937	96340263	285552	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6095
enhrx-59394	chr15	96808342	96808369	96265113	96265140	5206	hg19	N/A	enh16448	N/A	Enhatls63958	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.66636		-0.81401			NR2F2	chr15	96325937	96340263	59557	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6096
enhrx-59394	chr15	96809318	96809346	96266089	96266117	5207	hg19	N/A	enh16448	N/A	Enhatls63958	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98699		-0.48335			NR2F2	chr15	96325937	96340263	59557	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6096
enhrx-59437	chr15	99344101	99344128	98800872	98800899	5208	hg19	N/A	enh44218	N/A	Enhatls64003	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.17895		-0.71804			IGF1R	chr15	98648538	98964530	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6139
enhrx-59795	chr16	377509	377529	327509	327529	5209	hg19	N/A	enh16487	fant49639	Enhatls64345	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.7788		-0.44236			AXIN1	chr16	287439	352723	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	90
enhrx-63788	chr16	51225513	51225540	51191602	51191629	5210	hg19	N/A	N/A	N/A	Enhatls68469	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.65974		-1.0096			SALL1	chr16	51135981	51152334	35483	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4083
enhrx-63801	chr16	52531349	52531377	52497437	52497465	5211	hg19	hs62	enh52280	N/A	Enhatls68484	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.29038		-0.73998			TOX3	chr16	52436416	52547802	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4096
enhrx-63895	chr16	53789027	53789054	53755115	53755142	5212	hg19	N/A	enh4024	N/A	Enhatls68577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.99455		-0.48484			FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4190
enhrx-63895	chr16	53789085	53789112	53755173	53755200	5213	hg19	N/A	enh4024	N/A	Enhatls68577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.66273		-0.6164			FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4190
enhrx-63895	chr16	53796786	53796818	53762874	53762906	5214	hg19	N/A	N/A	N/A	Enhatls68577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.94458		-0.86879			FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4190
enhrx-65083	chr16	69430128	69430163	69396225	69396260	5215	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15688		-0.5168			TERF2	chr16	69355566	69408571	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5378
enhrx-65083	chr16	69430128	69430163	69396225	69396260	5216	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15688		-0.5168			CYB5B	chr16	69398401	69466264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5378
enhrx-65083	chr16	69430703	69430730	69396800	69396827	5217	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.64846		-0.61359			TERF2	chr16	69355566	69408571	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5378
enhrx-65083	chr16	69430703	69430730	69396800	69396827	5218	hg19	N/A	enh16750	N/A	Enhatls69850	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.64846		-0.61359			CYB5B	chr16	69398401	69466264	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5378
enhrx-65578	chr16	73403892	73403919	73369993	73370020	5219	hg19	N/A	N/A	N/A	Enhatls70370	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10903		-0.50738			ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5873
enhrx-65578	chr16	73403921	73403948	73370022	73370049	5220	hg19	N/A	N/A	N/A	Enhatls70370	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.50869		-0.58607			ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5873
enhrx-65578	chr16	73403921	73403948	73370022	73370049	5221	hg19	N/A	enh52314	N/A	Enhatls70370	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.50869		-0.58607			ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5873
enhrx-65578	chr16	73405665	73405693	73371766	73371794	5222	hg19	N/A	enh52314	N/A	Enhatls70370	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.74404		-0.63241			ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5873
enhrx-65849	chr16	78991995	78992022	78958098	78958125	5223	hg19	N/A	enh4146	N/A	Enhatls70660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.36938		-0.95243			WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6144
enhrx-65849	chr16	78992263	78992291	78958366	78958394	5224	hg19	N/A	enh4146	N/A	Enhatls70660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1196		-0.50946			WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6144
enhrx-65849	chr16	79035256	79035284	79001359	79001387	5225	hg19	N/A	enh52337	N/A	Enhatls70660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.68617		-0.42412			WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6144
enhrx-65849	chr16	79037050	79037080	79003153	79003183	5226	hg19	N/A	enh52337	N/A	Enhatls70660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.67149		-0.42123			WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6144
enhrx-65849	chr16	79202483	79202506	79168586	79168609	5227	hg19	N/A	enh52342	N/A	Enhatls70660	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22605		-0.53042			WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6144
enhrx-66209	chr16	85262573	85262611	85228967	85229005	5228	hg19	N/A	enh16864	N/A	Enhatls71072	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73594		-0.43392			GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6504
enhrx-66209	chr16	85272108	85272130	85238502	85238524	5229	hg19	N/A	enh16864	N/A	Enhatls71072	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10873		-0.50732			GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6504
enhrx-66209	chr16	85272255	85272286	85238649	85238680	5230	hg19	N/A	enh16864	N/A	Enhatls71072	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67121		-0.61807			GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6504
enhrx-68701	chr17	16159048	16159084	16255734	16255770	5231	hg19	N/A	enh17035	N/A	Enhatls73721	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05708		-0.49715			PIGL	chr17	16217208	16348801	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1970
enhrx-68701	chr17	16159160	16159190	16255846	16255876	5232	hg19	N/A	enh17035	N/A	Enhatls73721	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.24896		-0.53493			PIGL	chr17	16217208	16348801	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1970
enhrx-69765	chr17	28431790	28431825	30104772	30104807	5233	hg19	N/A	enh99410	N/A	Enhatls74895	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.90012		-0.66314			EFCAB5	chr17	29929199	30108452	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3034
enhrx-69765	chr17	28431838	28431863	30104820	30104845	5234	hg19	N/A	enh99410	N/A	Enhatls74895	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9153		-0.66613			EFCAB5	chr17	29929199	30108452	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3034
enhrx-lit74	chr17	38440545	38440568	40284293	40284316	5235	hg19					enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.98684		-0.48332								|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	
enhrx-70960	chr17	38440797	38440833	40284545	40284581	5236	hg19	N/A	N/A	fant52595	N/A	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.94153		-0.4744			WIPF2	chr17	40219303	40284136	368	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4229
enhrx-72090	chr17	44818849	44818877	46741483	46741511	5237	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.89412		-0.66196			NSF	chr17	46590668	46757679	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5359
enhrx-72931	chr17	55777530	55777558	57700169	57700197	5238	hg19	N/A	enh52536	N/A	Enhatls78294	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.04001		-0.49379			MSI2	chr17	57255850	57684689	11436	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6200
enhrx-73344	chr17	59222811	59222838	61145450	61145477	5239	hg19	N/A	enh48047	N/A	Enhatls78727	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.06066		-0.69475			BCAS3	chr17	60677452	61392838	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6613
enhrx-73804	chr17	63534840	63534868	65538722	65538750	5240	hg19	N/A	N/A	N/A	Enhatls79230	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22625		-0.53046			AXIN2	chr17	65528562	65561648	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	7073
enhrx-75216	chr17	76950193	76950223	78954111	78954141	5241	hg19	N/A	enh17420	fant54022	Enhatls80749	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.9268		-0.4715			LGALS3BP	chr17	78971237	78979935	16790	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8485
enhrx-75475	chr17	78806781	78806810	80832981	80833010	5242	hg19	N/A	enh4639	fant54157	Enhatls81002	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.52055		-0.7853			RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8744
enhrx-75475	chr17	78806920	78806958	80833120	80833158	5243	hg19	N/A	enh4639	fant54157	Enhatls81002	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.94844		-0.47576			RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	8744
enhrx-76023	chr18	362299	362326	362299	362326	5244	hg19	N/A	enh17469	N/A	Enhatls81575	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.87657		-0.46161			COLEC12	chr18	316736	500701	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	41
enhrx-76023	chr18	363628	363657	363628	363657	5245	hg19	N/A	enh17469	N/A	Enhatls81575	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.129635		0.32719			COLEC12	chr18	316736	500701	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	41
enhrx-76023	chr18	363911	363949	363911	363949	5246	hg19	N/A	enh17469	N/A	Enhatls81575	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1936		-0.52403			COLEC12	chr18	316736	500701	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	41
enhrx-76065	chr18	779031	779057	779030	779056	5247	hg19	N/A	enh17474	N/A	Enhatls81617	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.961321		0.29405			YES1	chr18	721587	812546	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	83
enhrx-76163	chr18	3048368	3048408	3048370	3048410	5248	hg19	N/A	enh17492	N/A	Enhatls81718	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.95748		-0.47754			MYOM1	chr18	3066806	3219968	8278	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	181
enhrx-76208	chr18	3618280	3618306	3618281	3618307	5249	hg19	N/A	enh17498	N/A	Enhatls81782	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.13537		-0.70946			DLGAP1	chr18	3496031	4455307	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	226
enhrx-76209	chr18	3665992	3666022	3665992	3666022	5250	hg19	N/A	enh17500	fant54427	Enhatls81783	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.40701		-0.56605			DLGAP1	chr18	3496031	4455307	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	227
enhrx-76364	chr18	7878857	7878886	7878859	7878888	5251	hg19	N/A	enh17530	N/A	Enhatls81948	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.081386		0.31769			PTPRM	chr18	7566781	8406861	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	382
enhrx-76364	chr18	7883281	7883307	7883283	7883309	5252	hg19	N/A	enh101522	N/A	Enhatls81948	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.5911		0.41805			PTPRM	chr18	7566781	8406861	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	382
enhrx-76967	chr18	20937418	20937448	23357454	23357484	5253	hg19	N/A	enh17603	N/A	Enhatls82589	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75456		-0.63448			TMEM241	chr18	23296012	23437961	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	985
enhrx-76972	chr18	20978705	20978727	23398741	23398763	5254	hg19	N/A	N/A	N/A	Enhatls82596	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36374		-0.55753			TMEM241	chr18	23296012	23437961	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	990
enhrx-77154	chr18	22391349	22391382	24811385	24811418	5255	hg19	N/A	enh52654	N/A	Enhatls82801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.2437		-0.73079			ZNF521	chr18	25061923	25352166	250033	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1172
enhrx-77154	chr18	22392518	22392541	24812554	24812577	5256	hg19	N/A	N/A	N/A	Enhatls82801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15261		-0.51596			ZNF521	chr18	25061923	25352166	249138	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1172
enhrx-77154	chr18	22398792	22398813	24818828	24818849	5257	hg19	N/A	enh69391	N/A	Enhatls82801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.89374		-0.46499			ZNF521	chr18	25061923	25352166	241793	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1172
enhrx-77154	chr18	22399556	22399583	24819592	24819619	5258	hg19	N/A	enh69391	N/A	Enhatls82801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.17973		-0.5213			ZNF521	chr18	25061923	25352166	241793	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1172
enhrx-77154	chr18	22614067	22614102	25034103	25034138	5259	hg19	N/A	N/A	N/A	Enhatls82801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97409		-0.48081			ZNF521	chr18	25061923	25352166	25057	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1172
enhrx-77222	chr18	25068318	25068345	27488354	27488381	5260	hg19	N/A	enh52661	N/A	Enhatls82873	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.25043		-0.53522			CHST9	chr18	26906480	27185308	300454	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1240
enhrx-77222	chr18	25120076	25120103	27540112	27540139	5261	hg19	N/A	enh52662	N/A	Enhatls82873	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.68104		-0.8169			CHST9	chr18	26906480	27185308	350034	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1240
enhrx-77222	chr18	25120224	25120252	27540260	27540288	5262	hg19	N/A	enh52662	N/A	Enhatls82873	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.19954		-0.5252			CHST9	chr18	26906480	27185308	350034	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1240
enhrx-77222	chr18	25121866	25121896	27541902	27541932	5263	hg19	N/A	enh52662	N/A	Enhatls82873	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.44708		-0.57394			CHST9	chr18	26906480	27185308	350034	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1240
enhrx-77288	chr18	28822207	28822233	31242244	31242270	5264	hg19	N/A	enh4744	N/A	Enhatls82939	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.18118		-0.71848			DSC1	chr18	31129235	31162856	65279	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1306
enhrx-77475	chr18	32275447	32275470	34695483	34695506	5265	hg19	N/A	enh32584	N/A	Enhatls83130	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29756		-0.5445			DTNA	chr18	34493290	34891844	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1493
enhrx-77691	chr18	39694495	39694521	42114531	42114557	5266	hg19	N/A	enh4805	N/A	Enhatls83355	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.0244		-0.68761			PIK3C3	chr18	41955233	42087830	22432	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1709
enhrx-77720	chr18	42381880	42381904	44801915	44801939	5267	hg19	N/A	enh32651	N/A	Enhatls83390	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.00362		-0.68352			SETBP1	chr18	44680172	45068510	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1738
enhrx-77726	chr18	42950709	42950738	45370744	45370773	5268	hg19	N/A	enh4813	N/A	Enhatls83397	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40978		-0.76349			SLC14A2	chr18	45212994	45683688	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1744
enhrx-77958	chr18	46501668	46501694	48975298	48975324	5269	hg19	N/A	enh17686	N/A	Enhatls83638	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.18562		-0.52246			SMAD7	chr18	48919852	48950965	15640	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1976
enhrx-78258	chr18	54578507	54578534	56911276	56911303	5270	hg19	N/A	enh17728	N/A	Enhatls83963	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.10596		-0.70367			WDR7	chr18	56651342	57029811	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2276
enhrx-78263	chr18	54669971	54669999	57002740	57002768	5271	hg19	N/A	enh32729	N/A	Enhatls83968	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.22366		-0.52995			WDR7	chr18	56651342	57029811	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2281
enhrx-78327	chr18	55845857	55845887	58178625	58178655	5272	hg19	N/A	enh17737	N/A	Enhatls84029	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.678965		0.43535			NEDD4L	chr18	58044225	58401540	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2345
enhrx-84212	chr19	38411622	38411649	37920982	37921009	5273	hg19	N/A	enh5115	N/A	Enhatls90271	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.41582		-0.76468			SIPA1L3	chr19	37907207	38208369	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5182
enhrx-84212	chr19	38444483	38444507	37953843	37953867	5274	hg19	N/A	enh5116	N/A	Enhatls90271	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.69759		-0.42637			SIPA1L3	chr19	37907207	38208369	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5182
enhrx-85232	chr19	43003455	43003490	42499303	42499338	5275	hg19	N/A	enh5163	N/A	Enhatls91365	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.81395		-0.44928			CEACAM1	chr19	42507303	42561234	6621	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6202
enhrx-102369	chr20	10521164	10521191	10540516	10540543	5276	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.9085		-0.66479			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102369	chr20	10521282	10521310	10540634	10540662	5277	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.30211		-0.74229			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102369	chr20	10521401	10521429	10540753	10540781	5278	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.91873		-0.46991			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102369	chr20	10521490	10521518	10540842	10540870	5279	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.40389		-0.76233			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102369	chr20	10521609	10521637	10540961	10540989	5280	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.2503		-0.73209			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102369	chr20	10521744	10521772	10541096	10541124	5281	hg19	N/A	enh19470	fant57992	Enhatls109444	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.64043		-0.61201			SLX4IP	chr20	10435304	10628030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	797
enhrx-102383	chr20	10692799	10692827	10712151	10712179	5282	hg19	N/A	enh34529	N/A	Enhatls109470	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.639197		0.42752			JAG1	chr20	10637683	10673999	37580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-102383	chr20	10697752	10697779	10717104	10717131	5283	hg19	N/A	enh34529	N/A	Enhatls109470	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.18349		-0.91583			JAG1	chr20	10637683	10673999	37580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-102383	chr20	10700531	10700561	10719883	10719913	5284	hg19	N/A	enh34529	N/A	Enhatls109470	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.03278		-0.68926			JAG1	chr20	10637683	10673999	37580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	811
enhrx-102389	chr20	11186879	11186907	11206231	11206259	5285	hg19	N/A	enh53683	N/A	Enhatls109478	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29858		-0.5447			JAG1	chr20	10637683	10673999	529119	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	817
enhrx-102389	chr20	11188904	11188933	11208256	11208285	5286	hg19	N/A	enh53683	N/A	Enhatls109478	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.41463		-0.56755			JAG1	chr20	10637683	10673999	529119	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	817
enhrx-102389	chr20	11197869	11197896	11217221	11217248	5287	hg19	N/A	enh34538	N/A	Enhatls109478	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.47364		-0.57917			JAG1	chr20	10637683	10673999	540639	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	817
enhrx-102390	chr20	11425836	11425863	11445188	11445215	5288	hg19	N/A	enh34544	N/A	Enhatls109480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.20015		-0.52532			BTBD3	chr20	11890722	11926609	432508	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	818
enhrx-102390	chr20	11428505	11428535	11447857	11447887	5289	hg19	N/A	enh34544	N/A	Enhatls109480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.75252		-0.63408			BTBD3	chr20	11890722	11926609	432508	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	818
enhrx-102390	chr20	11436035	11436061	11455387	11455413	5290	hg19	N/A	enh34544	N/A	Enhatls109480	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.29243		-0.54349			BTBD3	chr20	11890722	11926609	432508	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	818
enhrx-102467	chr20	13855249	13855275	13874603	13874629	5291	hg19	N/A	N/A	N/A	Enhatls109564	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.78663		-0.4439			SEL1L2	chr20	13849246	13996443	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	895
enhrx-102467	chr20	13855277	13855303	13874631	13874657	5292	hg19	N/A	N/A	N/A	Enhatls109564	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.79714		-0.44597			SEL1L2	chr20	13849246	13996443	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	895
enhrx-102480	chr20	14123024	14123052	14142378	14142406	5293	hg19	N/A	enh34555	N/A	Enhatls109577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.6804		-0.61988			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	908
enhrx-102480	chr20	14123101	14123142	14142455	14142496	5294	hg19	N/A	enh34555	N/A	Enhatls109577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.61966		-0.60792			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	908
enhrx-102480	chr20	14124073	14124101	14143427	14143455	5295	hg19	N/A	enh34555	N/A	Enhatls109577	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.885		-0.46327			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	908
enhrx-102490	chr20	14693529	14693559	14712883	14712913	5296	hg19	N/A	enh34558	N/A	Enhatls109587	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.15098		-0.51564			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	918
enhrx-102490	chr20	14697016	14697044	14716370	14716398	5297	hg19	N/A	enh34558	N/A	Enhatls109587	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05144		-0.49604			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	918
enhrx-102490	chr20	14697016	14697044	14716370	14716398	5298	hg19	N/A	enh34558	fant58047	Enhatls109587	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05144		-0.49604			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	918
enhrx-102496	chr20	15200855	15200880	15220209	15220234	5299	hg19	N/A	enh59070	N/A	Enhatls109594	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.25328		-0.92957			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-102496	chr20	15201027	15201052	15220381	15220406	5300	hg19	N/A	enh59070	N/A	Enhatls109594	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1872		-0.52277			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-102496	chr20	15206662	15206700	15226016	15226054	5301	hg19	N/A	N/A	N/A	Enhatls109594	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.674952		0.43456			MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	924
enhrx-103693	chr20	33914316	33914343	35326513	35326540	5302	hg19	N/A	enh34617	N/A	Enhatls110876	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.78927		-0.44442			UQCC1	chr20	35302565	35412031	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2121
enhrx-104027	chr20	36162972	36163001	37534570	37534599	5303	hg19	N/A	N/A	N/A	Enhatls111259	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.769013		0.45308			BLCAP	chr20	37517416	37527931	4998	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2455
enhrx-104871	chr20	46205601	46205628	47576857	47576884	5304	hg19	N/A	enh6517	N/A	Enhatls112131	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.21419		-0.72498			NCOA3	chr20	47501886	47656877	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3299
enhrx-105210	chr20	52238000	52238025	53621461	53621486	5305	hg19	N/A	enh19752	N/A	Enhatls112526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.03255		-0.88611			ZNF217	chr20	53567070	53608892	6995	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52238000	52238025	53621461	53621486	5306	hg19	N/A	enh19752	fant59184	Enhatls112526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.03255		-0.88611			ZNF217	chr20	53567070	53608892	12580	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52295336	52295363	53678797	53678824	5307	hg19	N/A	enh19755	N/A	Enhatls112526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.58553		-0.6012			ZNF217	chr20	53567070	53608892	69475	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52296371	52296401	53679832	53679862	5308	hg19	N/A	enh19755	N/A	Enhatls112526	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.403487		0.38111			ZNF217	chr20	53567070	53608892	69475	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52380792	52380816	53764253	53764277	5309	hg19	N/A	enh19758	N/A	Enhatls112526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.18791		-0.9167			ZNF217	chr20	53567070	53608892	155317	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52481224	52481245	53864685	53864706	5310	hg19	N/A	enh19762	fant59215	Enhatls112526	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	1.857611		0.27363			BCAS1	chr20	53936776	54070594	71991	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-105210	chr20	52482479	52482509	53865940	53865970	5311	hg19	N/A	enh19762	N/A	Enhatls112526	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92452		-0.47105			BCAS1	chr20	53936776	54070594	70780	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3638
enhrx-106093	chr20	62820585	62820611	64189232	64189258	5312	hg19	N/A	N/A	fant59615	Enhatls113439	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.88044		-0.85616			MYT1	chr20	64102393	64242253	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-106093	chr20	62820670	62820696	64189317	64189343	5313	hg19	N/A	N/A	fant59615	Enhatls113439	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97068		-0.48014			MYT1	chr20	64102393	64242253	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-106093	chr20	62820726	62820753	64189373	64189400	5314	hg19	N/A	N/A	fant59615	Enhatls113439	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.33829		-0.55252			MYT1	chr20	64102393	64242253	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-106093	chr20	62820783	62820810	64189430	64189457	5315	hg19	N/A	N/A	fant59615	Enhatls113439	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.49467		-0.58331			MYT1	chr20	64102393	64242253	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	4521
enhrx-106294	chr21	16249009	16249041	14876688	14876720	5316	hg19	N/A	enh19821	N/A	Enhatls113648	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.00703		-0.68419			NRIP1	chr21	14961234	15065815	81699	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	177
enhrx-106329	chr21	17827009	17827034	16454689	16454714	5317	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-6.64811		-1.4011			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17827324	17827356	16455004	16455036	5318	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.14265		-0.514			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17827941	17827968	16455621	16455648	5319	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11955		-0.50945			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17828180	17828208	16455860	16455888	5320	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.39426		-0.56354			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17828329	17828357	16456009	16456037	5321	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.12785		-0.70798			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17828628	17828656	16456308	16456336	5322	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.21284		-0.52782			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17829870	17829900	16457550	16457580	5323	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.97089		-0.48018			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106329	chr21	17829933	17829962	16457613	16457642	5324	hg19	N/A	enh99899	N/A	Enhatls113684	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.00621		-0.68403			USP25	chr21	15729981	15880064	572402	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	212
enhrx-106335	chr21	18840590	18840624	17468272	17468306	5325	hg19	N/A	enh34795	N/A	Enhatls113693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.53393		-0.59104			CXADR	chr21	17513042	17593579	42826	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	218
enhrx-106621	chr21	30955146	30955172	29582826	29582852	5326	hg19	N/A	N/A	N/A	Enhatls114005	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.604204		0.42063			BACH1	chr21	29194070	29630751	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	504
enhrx-106621	chr21	30955146	30955172	29582826	29582852	5327	hg19	N/A	N/A	N/A	Enhatls114005	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.604204		0.42063			GRIK1	chr21	29536932	29940022	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	504
enhrx-106621	chr21	30955637	30955666	29583317	29583346	5328	hg19	N/A	N/A	N/A	Enhatls114005	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.296425		0.36003			BACH1	chr21	29194070	29630751	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	504
enhrx-106621	chr21	30955637	30955666	29583317	29583346	5329	hg19	N/A	N/A	N/A	Enhatls114005	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.296425		0.36003			GRIK1	chr21	29536932	29940022	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	504
enhrx-106976	chr21	35486290	35486323	34113991	34114024	5330	hg19	N/A	enh53854	N/A	Enhatls114374	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.27349		-0.53976			MRPS6	chr21	34073577	34143030	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	859
enhrx-108555	chr22	19953510	19953547	19965987	19966024	5331	hg19	N/A	N/A	N/A	Enhatls116085	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.81642		-0.64666			COMT	chr22	19941370	19969975	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	386
enhrx-109325	chr22	28277642	28277665	27881654	27881677	5332	hg19	N/A	enh6808	N/A	Enhatls116993	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.6495		-0.81069			PITPNB	chr22	27851668	27920134	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1156
enhrx-109385	chr22	29347945	29347972	28951957	28951984	5333	hg19	N/A	enh20116	N/A	Enhatls117056	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.48962		-0.77921			ZNRF3	chr22	28883571	29057488	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1216
enhrx-109397	chr22	29492992	29493019	29097004	29097031	5334	hg19	N/A	enh93107	N/A	Enhatls117070	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.20419		-0.72301			KREMEN1	chr22	29073034	29168333	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1228
enhrx-109570	chr22	30614070	30614099	30218081	30218110	5335	hg19	N/A	enh20126	fant61008	Enhatls117249	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.05657		-0.49705			LIF	chr22	30240452	30246759	22284	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1401
enhrx-109573	chr22	30647901	30647927	30251912	30251938	5336	hg19	N/A	enh95085	fant61018	Enhatls117252	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.37765		-0.56027			LIF	chr22	30240452	30246759	5093	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1404
enhrx-109573	chr22	30650495	30650523	30254506	30254534	5337	hg19	N/A	enh95085	fant61021	Enhatls117252	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.64572		-0.61305			LIF	chr22	30240452	30246759	7592	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1404
enhrx-109573	chr22	30650584	30650612	30254595	30254623	5338	hg19	N/A	enh95085	fant61021	Enhatls117252	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.36003		-0.5568			LIF	chr22	30240452	30246759	7592	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1404
enhrx-109573	chr22	30653408	30653438	30257419	30257449	5339	hg19	N/A	enh95085	fant61023	Enhatls117252	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.06444		-0.4986			OSM	chr22	30262828	30266851	4507	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1404
enhrx-110075	chr22	36317993	36318029	35921945	35921981	5340	hg19	N/A	enh20173	N/A	Enhatls117793	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.27057		-0.73608			RBFOX2	chr22	35738735	36028824	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1906
enhrx-110445	chr22	38679394	38679419	38283388	38283413	5341	hg19	N/A	enh20206	N/A	Enhatls118199	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.33469		-0.55181			CSNK1E	chr22	38290690	38318084	7	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	2276
enhrx-111839	chr22	51136933	51136962	50698505	50698534	5342	hg19	N/A	N/A	N/A	Enhatls119688	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.32387		-0.54968			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3670
enhrx-111844	chr22	51143794	51143822	50705366	50705394	5343	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.28489		-0.7389			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-111844	chr22	51143824	51143851	50705396	50705423	5344	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.49282		-0.77984			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-111844	chr22	51143883	51143911	50705455	50705483	5345	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.31264		-0.54747			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-111844	chr22	51143942	51143970	50705514	50705542	5346	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.55369		-0.59493			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-111844	chr22	51144340	51144367	50705912	50705939	5347	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.95085		-0.67313			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-111844	chr22	51144398	51144425	50705970	50705997	5348	hg19	N/A	N/A	N/A	Enhatls119693	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.59795		-0.80054			SHANK3	chr22	50674414	50733212	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3675
enhrx-170799	chrX	11007932	11007960	10989812	10989840	5349	hg19	N/A	enh46949	N/A	Enhatls182772	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-3.30424		-0.74271			HCCS	chrX	11111300	11123086	116346	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	516
enhrx-170827	chrX	11517934	11517959	11499814	11499839	5350	hg19	N/A	enh57203	N/A	Enhatls182801	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.38339		-0.5614			ARHGAP6	chrX	11117650	11665920	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	544
enhrx-170875	chrX	13026111	13026139	13007992	13008020	5351	hg19	N/A	enh11118	N/A	Enhatls182848	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.554431		0.41083			FAM9C	chrX	13035616	13044682	27489	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	592
enhrx-171139	chrX	17602254	17602280	17584133	17584159	5352	hg19	N/A	enh42449	N/A	Enhatls183134	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07373		-0.50043			NHS	chrX	17375199	17735994	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	856
enhrx-171139	chrX	17609455	17609480	17591334	17591359	5353	hg19	N/A	enh42450	N/A	Enhatls183134	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.11183		-0.50793			NHS	chrX	17375199	17735994	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	856
enhrx-171139	chrX	17626590	17626618	17608470	17608498	5354	hg19	N/A	enh42450	N/A	Enhatls183134	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.07836		-0.50134			NHS	chrX	17375199	17735994	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	856
enhrx-171410	chrX	21756835	21756864	21738717	21738746	5355	hg19	N/A	enh26186	N/A	Enhatls183429	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.67639		-0.61909			SMPX	chrX	21705977	21758116	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1127
enhrx-171411	chrX	21762236	21762276	21744118	21744158	5356	hg19	N/A	enh57242	N/A	Enhatls183430	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.249242		0.35074			SMPX	chrX	21705977	21758116	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1128
enhrx-171411	chrX	21766483	21766508	21748365	21748390	5357	hg19	N/A	enh57242	N/A	Enhatls183430	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.659693		0.62845			SMPX	chrX	21705977	21758116	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1128
enhrx-171411	chrX	21768260	21768289	21750142	21750171	5358	hg19	N/A	enh57242	N/A	Enhatls183430	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.73602		-0.63083			SMPX	chrX	21705977	21758116	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1128
enhrx-171411	chrX	21768383	21768412	21750265	21750294	5359	hg19	N/A	enh57242	N/A	Enhatls183430	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.92175		-0.6674			SMPX	chrX	21705977	21758116	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1128
enhrx-171424	chrX	21994185	21994206	21976067	21976088	5360	hg19	N/A	enh42471	N/A	Enhatls183445	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	3.238655		0.54555			SMS	chrX	21940708	21994837	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1141
enhrx-171424	chrX	21994208	21994230	21976090	21976112	5361	hg19	N/A	enh42471	N/A	Enhatls183445	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-4.54039		-0.9861			SMS	chrX	21940708	21994837	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1141
enhrx-171573	chrX	24894650	24894678	24876533	24876561	5362	hg19	hs118	enh57255	N/A	Enhatls183603	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-5.1468		-1.1055			POLA1	chrX	24693917	24996986	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1290
enhrx-171573	chrX	24897789	24897818	24879672	24879701	5363	hg19	N/A	enh57255	N/A	Enhatls183603	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.822595		0.46363			POLA1	chrX	24693917	24996986	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1290
enhrx-171698	chrX	31652587	31652614	31634470	31634497	5364	hg19	N/A	N/A	N/A	Enhatls183729	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.93955		-0.47401			DMD	chrX	31119218	33339609	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1415
enhrx-172016	chrX	40886910	40886939	41027657	41027686	5365	hg19	N/A	enh26233	N/A	Enhatls184058	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.90966		-0.66502			USP9X	chrX	41085444	41236579	51853	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	1733
enhrx-173765	chrX	71161793	71161820	71941943	71941970	5366	hg19	N/A	enh42650	N/A	Enhatls185937	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.92472		-0.47109			NHSL2	chrX	71910844	72153286	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3482
enhrx-173765	chrX	71165533	71165563	71945683	71945713	5367	hg19	N/A	N/A	N/A	Enhatls185937	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.10319		-0.50623			NHSL2	chrX	71910844	72153286	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3482
enhrx-174175	chrX	80514766	80514793	81259267	81259294	5368	hg19	N/A	enh42670	N/A	Enhatls186343	enhancer		|		|		Knockout of the enhancer increases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	2.654637		0.43056			SH3BGRL	chrX	81202101	81298547	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	3892
enhrx-175482	chrX	109257857	109257894	110014629	110014666	5369	hg19	N/A	enh26375	N/A	Enhatls187669	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.08983		-0.5036			TMEM164	chrX	110002634	110177788	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	5199
enhrx-176374	chrX	132010417	132010442	132876389	132876414	5370	hg19	N/A	enh85865	N/A	Enhatls188597	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	direct	Highly Significant	-2.1035		-0.50629			HS6ST2	chrX	132626014	132961395	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6091
enhrx-176374	chrX	132011065	132011091	132877037	132877063	5371	hg19	N/A	enh85865	N/A	Enhatls188597	enhancer		|		|		Knockout of the enhancer decreases proliferation.	Embryonic brain tissue	human neural stem cells (hNSCs)	CCND2 and SOX2	indirect	weak Significant	-1.73076		-0.4329			HS6ST2	chrX	132626014	132961395	0	|	|	|	CRISPR-Cas9	Massively parallel disruption of enhancers active in human neural stem cells	https://doi.org/10.1016/j.celrep.2024.113693	38271204	6091
enhrx-122093	chr3	194581610	194581611	194860881	194860882	5372	hg38	N/A	enh21260	N/A	Enhatls130677	enhancer	E1	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38085	0.0000119		FAM43A	chr3	194685882	194689037	158500	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10222
enhrx-122411	chr3	197607720	197607721	197880849	197880850	5373	hg38	N/A	N/A	N/A	Enhatls131018	enhancer	E2	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.54652	0.00011142		LRCH3	chr3	197791234	197888436	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10540
enhrx-66237	chr16	85811654	85811655	85778048	85778049	5374	hg38	N/A	N/A	N/A	Enhatls71107	enhancer	E3	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.49548	0.00051757		EMC8	chr16	85778623	85799608	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6532
enhrx-70824	chr17	37859765	37859766	39703512	39703513	5375	hg38	N/A	enh17134	N/A	Enhatls75991	enhancer	E4	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.519	0.00067087		ERBB2	chr17	39687913	39728662	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4093
enhrx-122172	chr3	195587446	195587447	195860575	195860576	5376	hg38	N/A	enh21278	N/A	Enhatls130769	enhancer	E5	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.52721	0.00072697		TNK2	chr3	195863363	195909802	1707	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10301
enhrx-168760	chr9	131815030	131815031	129052751	129052752	5377	hg38	N/A	N/A	N/A	Enhatls180626	enhancer	E6	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3532	0.00097271		MIGA2	chr9	129036625	129072082	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6027
enhrx-11219	chr1	156664605	156664606	156694813	156694814	5378	hg38	N/A	enh43056	N/A	Enhatls12487	enhancer	E7	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31543	0.0010059		CRABP2	chr1	156699605	156705816	3203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11218
enhrx-10413	chr1	151705797	151705798	151733321	151733322	5379	hg38	N/A	enh95905	N/A	Enhatls11617	enhancer	E8	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41279	0.0010059		RIIAD1	chr1	151710432	151729805	1425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10412
enhrx-169125	chr9	134420852	134420853	131545465	131545466	5380	hg38	N/A	N/A	N/A	Enhatls181037	enhancer	E9	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.40834	0.0010059		PRRT1B	chr9	131545522	131559815	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6392
enhrx-122093	chr3	194696873	194696874	194976144	194976145	5381	hg38	N/A	N/A	N/A	Enhatls130677	enhancer	E10	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.53412	0.0012588		XXYLT1	chr3	195068283	195271159	85648	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10222
enhrx-34551	chr11	130632755	130632756	130762860	130762861	5382	hg38	N/A	enh67983	N/A	Enhatls37487	enhancer	E11	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.40629	0.0014626		SNX19	chr11	130866249	130916479	96790	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9220
enhrx-30909	chr11	70917408	70917409	71206362	71206363	5383	hg38	N/A	enh14050	N/A	Enhatls33604	enhancer	E12	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.49091	0.0015053		SHANK2	chr11	70467853	71252577	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5578
enhrx-113970	chr3	42246914	42246915	42205422	42205423	5384	hg38	N/A	N/A	N/A	Enhatls121963	enhancer	E13	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.39689	0.0019257		TRAK1	chr3	42013801	42225890	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2099
enhrx-122307	chr3	196717021	196717022	196990150	196990151	5385	hg38	N/A	N/A	N/A	Enhatls130910	enhancer	E14	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.46328	0.0021959		MELTF	chr3	197001739	197029835	8298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10436
enhrx-120701	chr3	169404866	169404867	169687078	169687079	5386	hg38	N/A	enh110097	N/A	Enhatls129147	enhancer	E15	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31853	0.0021975		MECOM	chr3	169083498	169663775	21203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8830
enhrx-149572	chr7	44573895	44573896	44534296	44534297	5387	hg38	N/A	N/A	N/A	Enhatls159873	enhancer	E16	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.39837	0.0023097		NPC1L1	chr7	44512534	44541330	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2384
enhrx-102979	chr20	25158682	25158683	25178046	25178047	5388	hg38	N/A	enh19566	N/A	Enhatls110106	enhancer	E17	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.4185	0.0023555		ENTPD6	chr20	25195692	25228075	14159	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1407
enhrx-121206	chr3	181854132	181854133	182136344	182136345	5389	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	E18	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.42523	0.0023555		SOX2	chr3	181711924	181714436	419802	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9335
enhrx-11790	chr1	160960550	160960551	160990760	160990761	5390	hg38	N/A	enh67134	N/A	Enhatls13073	enhancer	E19	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.46326	0.0027001		F11R	chr1	160995210	161021343	826	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11789
enhrx-121784	chr3	186825940	186825941	187108152	187108153	5391	hg38	N/A	N/A	N/A	Enhatls130329	enhancer	E20	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20409	0.0028676		RPL39L	chr3	187120947	187180908	12671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9913
enhrx-63942	chr16	55671082	55671083	55637170	55637171	5392	hg38	N/A	enh92677	N/A	Enhatls68629	enhancer	E21	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.29645	0.0028834		SLC6A2	chr16	55655987	55706240	12761	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4237
enhrx-66361	chr16	88576945	88576946	88510537	88510538	5393	hg38	N/A	enh52393	N/A	Enhatls71260	enhancer	E22	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.25123	0.0030193		ZFPM1	chr16	88453279	88537031	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6656
enhrx-21369	chr10	76681548	76681549	74921790	74921791	5394	hg38	N/A	enh1348	N/A	Enhatls23502	enhancer	E23	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27661	0.0030888		KAT6B	chr10	74824926	75032624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3804
enhrx-160682	chr8	102604059	102604060	101591831	101591832	5395	hg38	N/A	enh59894	N/A	Enhatls171629	enhancer	E24	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.46467	0.0031204		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4473
enhrx-120987	chr3	177128740	177128741	177410952	177410953	5396	hg38	N/A	enh21138	N/A	Enhatls129464	enhancer	E25	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.60936	0.0032469		TBL1XR1	chr3	177019343	177228000	179558	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-16540	chr1	231521278	231521279	231385532	231385533	5397	hg38	N/A	enh984	N/A	Enhatls18131	enhancer	E26	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31486	0.00328		EGLN1	chr1	231363750	231422287	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16539
enhrx-161142	chr8	116678678	116678679	115666451	115666452	5398	hg38	N/A	enh100852	fant30568	Enhatls172100	enhancer	E27	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3756	0.0033765		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4933
enhrx-150355	chr7	69197446	69197447	69732460	69732461	5399	hg38	N/A	N/A	N/A	Enhatls160731	enhancer	E28	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.39548	0.0033923		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3167
enhrx-66210	chr16	85492716	85492717	85459110	85459111	5400	hg38	N/A	enh16870	N/A	Enhatls71076	enhancer	E29	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41431	0.0036467		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-31485	chr11	76499899	76499900	76788855	76788856	5401	hg38	N/A	enh14113	N/A	Enhatls34226	enhancer	E30	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37208	0.0036483		TSKU	chr11	76782250	76798153	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6154
enhrx-38040	chr12	49647041	49647042	49253258	49253259	5402	hg38	N/A	enh96297	N/A	Enhatls41177	enhancer	E31	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28659	0.0036799		TUBA1C	chr12	49227925	49274600	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3350
enhrx-122063	chr3	194215892	194215893	194495163	194495164	5403	hg38	N/A	enh7798	N/A	Enhatls130644	enhancer	E32	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33627	0.0039485		ATP13A3	chr3	194402673	194487002	3330	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10192
enhrx-90150	chr2	37916553	37916554	37689410	37689411	5404	hg38	N/A	N/A	N/A	Enhatls96565	enhancer	E33	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37233	0.0040291		CDC42EP3	chr2	37641881	37738468	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2076
enhrx-33995	chr11	121520692	121520693	121649983	121649984	5405	hg38	N/A	N/A	N/A	Enhatls36887	enhancer	E34	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.5186	0.0040766		SORL1	chr11	121452313	121633763	12664	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8664
enhrx-122414	chr3	197633525	197633526	197906654	197906655	5406	hg38	N/A	N/A	N/A	Enhatls131021	enhancer	E35	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35523	0.004252		IQCG	chr3	197889076	197959991	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10543
enhrx-146138	chr6	152168311	152168312	151847176	151847177	5407	hg38	N/A	N/A	N/A	Enhatls156209	enhancer	E36	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.45967	0.004331		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7726
enhrx-4739	chr1	42334045	42334046	41868374	41868375	5408	hg38	N/A	N/A	N/A	Enhatls5201	enhancer	E37	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.40476	0.0044764		HIVEP3	chr1	41506364	41918922	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4738
enhrx-136574	chr5	149249974	149249975	149870411	149870412	5409	hg38	N/A	enh22705	N/A	Enhatls145911	enhancer	E38	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.53151	0.0052824		PDE6A	chr5	149857952	149944793	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6365
enhrx-149838	chr7	48219679	48219680	48180082	48180083	5410	hg38	N/A	enh40179	N/A	Enhatls160171	enhancer	E39	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38429	0.0055779		ABCA13	chr7	48171457	48647497	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2650
enhrx-140494	chr6	33950996	33950997	33983219	33983220	5411	hg38	N/A	enh89003	fant22302	Enhatls150196	enhancer	E40	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3008	0.0056158		GRM4	chr6	34018642	34155622	35276	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2082
enhrx-130333	chr5	957689	957690	957574	957575	5412	hg38	N/A	enh22023	N/A	Enhatls139318	enhancer	E41	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26941	0.0056538		TRIP13	chr5	892883	918120	39251	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	124
enhrx-122029	chr3	193876896	193876897	194159107	194159108	5413	hg38	N/A	enh21246	fant14696	Enhatls130600	enhancer	E42	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.0083533	0.0057928		HES1	chr3	194136147	194138732	20215	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10158
enhrx-147766	chr7	6098392	6098393	6058761	6058762	5414	hg38	N/A	N/A	N/A	Enhatls157913	enhancer	E43	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.043505	0.0058687		EIF2AK1	chr7	6022246	6059175	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	578
enhrx-10413	chr1	151712632	151712633	151740156	151740157	5415	hg38	N/A	enh12256	N/A	Enhatls11617	enhancer	E44	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.42443	0.006259		RIIAD1	chr1	151710432	151729805	7865	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10412
enhrx-161139	chr8	116597860	116597861	115585633	115585634	5416	hg38	N/A	N/A	N/A	Enhatls172096	enhancer	E45	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.43363	0.0062606		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4930
enhrx-20671	chr10	70286591	70286592	68526834	68526835	5417	hg38	N/A	N/A	N/A	Enhatls22762	enhancer	E46	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36435	0.006278		SLC25A16	chr10	68477997	68527523	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-122414	chr3	197633848	197633849	197906977	197906978	5418	hg38	N/A	N/A	N/A	Enhatls131021	enhancer	E47	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.29818	0.006534		IQCG	chr3	197889076	197959991	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10543
enhrx-43822	chr12	124673227	124673228	124188681	124188682	5419	hg38	N/A	enh43846	N/A	Enhatls47303	enhancer	E48	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35207	0.0066241		RFLNA	chr12	123973240	124316024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9132
enhrx-121779	chr3	186613361	186613362	186895572	186895573	5420	hg38	N/A	N/A	N/A	Enhatls130320	enhancer	E49	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37538	0.0068643		ST6GAL1	chr3	186930525	187078553	31070	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9908
enhrx-16861	chr1	236666037	236666038	236502737	236502738	5421	hg38	N/A	N/A	N/A	Enhatls18462	enhancer	E50	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.17683	0.0085047		EDARADD	chr1	236348256	236484930	13871	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16860
enhrx-122121	chr3	195286766	195286767	195559923	195559924	5422	hg38	N/A	enh21274	N/A	Enhatls130715	enhancer	E51	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3725	0.0086217		APOD	chr3	195568704	195583940	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10250
enhrx-73846	chr17	64672796	64672797	66676678	66676679	5423	hg38	N/A	enh48052	N/A	Enhatls79280	enhancer	E52	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35943	0.0086659		PRKCA	chr17	66302612	66810743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7115
enhrx-105096	chr20	48866204	48866205	50249667	50249668	5424	hg38	N/A	enh19714	N/A	Enhatls112385	enhancer	E53	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33418	0.0089077		CEBPB	chr20	50190829	50192668	55977	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3524
enhrx-172180	chrX	44795075	44795076	44935830	44935831	5425	hg38	N/A	enh109248	N/A	Enhatls184223	enhancer	E54	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37549	0.0093344		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1897
enhrx-16334	chr1	228803163	228803164	228667416	228667417	5426	hg38	N/A	enh12745	N/A	Enhatls17926	enhancer	E55	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.4191	0.0093992		RHOU	chr1	228735478	228746664	64967	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16333
enhrx-66075	chr16	84130391	84130392	84096786	84096787	5427	hg38	N/A	enh81155	fant51184	Enhatls70927	enhancer	E56	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.24406	0.009995		MBTPS1	chr16	84053762	84116942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6370
enhrx-160819	chr8	104609640	104609641	103597412	103597413	5428	hg38	N/A	enh73431	N/A	Enhatls171770	enhancer	E57	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.11731	0.010072		RIMS2	chr8	103500609	104254430	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4610
enhrx-151920	chr7	95238213	95238214	95608901	95608902	5429	hg38	"hs1831,hs1831"	enh24342	fant27085	Enhatls162387	enhancer	E58	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.25399	0.010248		PDK4	chr7	95583498	95596516	12278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4732
enhrx-66210	chr16	85558275	85558276	85524669	85524670	5430	hg38	N/A	enh16872	fant51277	Enhatls71076	enhancer	E59	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34519	0.010509		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-107427	chr21	43025917	43025918	41605757	41605758	5431	hg38	N/A	enh63043	N/A	N/A	enhancer	E60	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41699	0.010509		TMPRSS2	chr21	41464299	41531116	66110	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1310
enhrx-16681	chr1	234812181	234812182	234676435	234676436	5432	hg38	N/A	enh12794	fant5292	Enhatls18288	enhancer	E61	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38633	0.010509		IRF2BP2	chr1	234604268	234610178	66141	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-148020	chr7	11233288	11233289	11193661	11193662	5433	hg38	N/A	enh97976	N/A	Enhatls158185	enhancer	E62	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38831	0.010992		PHF14	chr7	10973335	11169618	21981	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	832
enhrx-106991	chr21	36067914	36067915	34695615	34695616	5434	hg38	N/A	enh53855	N/A	Enhatls114393	enhancer	E63	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.29034	0.010992		CLIC6	chr21	34668993	34718227	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	874
enhrx-150352	chr7	67642278	67642279	68177291	68177292	5435	hg38	N/A	N/A	N/A	Enhatls160728	enhancer	E64	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28976	0.011256		SPDYE21	chr7	67276940	67289005	859244	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3164
enhrx-14028	chr1	200120120	200120121	200150992	200150993	5436	hg38	N/A	enh47277	N/A	Enhatls15456	enhancer	E65	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37751	0.011409		NR5A2	chr1	200027613	200177420	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14027
enhrx-72872	chr17	54886136	54886137	56808775	56808776	5437	hg38	N/A	enh62629	N/A	Enhatls78224	enhancer	E66	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31633	0.01143		C17orf67	chr17	56791912	56833920	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6141
enhrx-74229	chr17	70614250	70614251	72618111	72618112	5438	hg38	N/A	enh32352	N/A	Enhatls79691	enhancer	E67	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.71788	0.011849		SLC39A11	chr17	72645948	73092712	27638	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7498
enhrx-104149	chr20	37233679	37233680	38605036	38605037	5439	hg38	N/A	enh82263	N/A	Enhatls111394	enhancer	E68	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36216	0.011963		ARHGAP40	chr20	38601808	38651035	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2577
enhrx-138797	chr6	10105903	10105904	10105670	10105671	5440	hg38	N/A	N/A	N/A	Enhatls148385	enhancer	E69	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38107	0.012046		TFAP2A	chr6	10393185	10419638	258572	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	385
enhrx-161140	chr8	116604415	116604416	115592188	115592189	5441	hg38	N/A	enh98197	N/A	Enhatls172097	enhancer	E70	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36866	0.012061		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4931
enhrx-40010	chr12	68759308	68759309	68365528	68365529	5442	hg38	N/A	enh14803	fant42188	Enhatls43259	enhancer	E71	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27334	0.012097		MDM1	chr12	68294565	68332381	32534	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5320
enhrx-11787	chr1	160921321	160921322	160951531	160951532	5443	hg38	N/A	N/A	N/A	Enhatls13070	enhancer	E72	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.21365	0.012424		ITLN2	chr1	160945024	160954809	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11786
enhrx-141077	chr6	39243425	39243426	39275649	39275650	5444	hg38	N/A	enh23217	N/A	Enhatls150817	enhancer	E73	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26248	0.012426		KCNK17	chr6	39299000	39314461	15302	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2665
enhrx-34610	chr11	133878752	133878753	134008857	134008858	5445	hg38	N/A	enh2125	N/A	Enhatls37553	enhancer	E74	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36781	0.013075		IGSF9B	chr11	133896437	133956968	49763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9279
enhrx-14587	chr1	204367807	204367808	204398679	204398680	5446	hg38	N/A	enh12581	N/A	Enhatls16060	enhancer	E75	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35486	0.013211		PPP1R15B	chr1	204398889	204411817	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14586
enhrx-10078	chr1	150206403	150206404	150234058	150234059	5447	hg38	N/A	N/A	N/A	Enhatls11278	enhancer	E76	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.49633	0.013334		ANP32E	chr1	150218416	150236156	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10077
enhrx-21711	chr10	86871217	86871218	85111461	85111462	5448	hg38	N/A	N/A	N/A	Enhatls23898	enhancer	E77	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.15845	0.013402		GRID1	chr10	85599551	86366795	476923	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4146
enhrx-11865	chr1	161206105	161206106	161236315	161236316	5449	hg38	N/A	N/A	N/A	Enhatls13146	enhancer	E78	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31639	0.013978		NR1I3	chr1	161229665	161238244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11864
enhrx-52446	chr14	96612583	96612584	96146246	96146247	5450	hg38	N/A	enh15909	N/A	Enhatls56568	enhancer	E80	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.45243	0.014195		C14orf132	chr14	96039361	96093971	49565	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4403
enhrx-64525	chr16	65549210	65549211	65515307	65515308	5451	hg38	N/A	N/A	N/A	Enhatls69257	enhancer	E81	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38664	0.014524		CDH11	chr16	64943752	65122365	390688	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4820
enhrx-104211	chr20	39277302	39277303	40648662	40648663	5452	hg38	N/A	enh34640	N/A	Enhatls111459	enhancer	E82	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31186	0.01464		MAFB	chr20	40685847	40689236	31113	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2639
enhrx-122367	chr3	197395036	197395037	197668165	197668166	5453	hg38	N/A	enh91517	N/A	Enhatls130971	enhancer	E83	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.5022	0.014798		RUBCN	chr3	197668866	197749699	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10496
enhrx-170116	chr9	140193269	140193270	137298817	137298818	5454	hg38	N/A	enh26121	N/A	Enhatls182039	enhancer	E84	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38612	0.014975		NRARP	chr9	137299630	137302271	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7383
enhrx-101710	chr20	1408613	1408614	1427969	1427970	5455	hg38	N/A	enh19437	N/A	Enhatls108773	enhancer	E85	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34636	0.014976		NSFL1C	chr20	1442161	1466918	9791	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	138
enhrx-112450	chr3	11583703	11583704	11542229	11542230	5456	hg38	N/A	enh7001	N/A	Enhatls120326	enhancer	E86	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26693	0.014976		ATG7	chr3	11272308	11557665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	579
enhrx-122307	chr3	196717283	196717284	196990412	196990413	5457	hg38	N/A	N/A	N/A	Enhatls130910	enhancer	E87	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.242	0.01537		MELTF	chr3	197001739	197029835	8298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10436
enhrx-105299	chr20	55363496	55363497	56788440	56788441	5458	hg38	N/A	enh19783	fant59292	Enhatls112614	enhancer	E88	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33121	0.015386		TFAP2C	chr20	56629305	56639283	149129	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-136962	chr5	154224614	154224615	154845054	154845055	5459	hg38	N/A	enh66105	fant20461	Enhatls146357	enhancer	E89	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33448	0.01551		FAXDC2	chr5	154818491	154859252	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6753
enhrx-73344	chr17	59357319	59357320	61279958	61279959	5460	hg38	N/A	enh62635	N/A	Enhatls78727	enhancer	E90	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.15312	0.015719		BCAS3	chr17	60677452	61392838	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6613
enhrx-165845	chr9	91637277	91637278	89022362	89022363	5461	hg38	N/A	enh25712	N/A	Enhatls177479	enhancer	E91	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.17679	0.016517		SHC3	chr9	89005770	89178818	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3112
enhrx-44110	chr12	132280823	132280824	131796278	131796279	5462	hg38	N/A	N/A	N/A	Enhatls47626	enhancer	E92	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34393	0.016519		SFSWAP	chr12	131711089	131799738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9420
enhrx-140478	chr6	33699843	33699844	33732066	33732067	5463	hg38	N/A	enh23160	N/A	Enhatls150179	enhancer	E93	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36555	0.016547		IP6K3	chr6	33721661	33746905	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2066
enhrx-27587	chr11	30429072	30429073	30407525	30407526	5464	hg38	N/A	enh67750	N/A	Enhatls30037	enhancer	E94	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36639	0.016621		MPPED2	chr11	30384492	30586872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2256
enhrx-78700	chr18	67420244	67420245	69753008	69753009	5465	hg38	N/A	enh92811	N/A	Enhatls84434	enhancer	E95	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.32458	0.016708		DOK6	chr18	69400887	69849087	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2718
enhrx-122026	chr3	193590273	193590274	193872484	193872485	5466	hg38	N/A	enh21241	fant14682	Enhatls130592	enhancer	E96	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36811	0.016927		OPA1	chr3	193593143	193697811	174531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10155
enhrx-103500	chr20	32551362	32551363	33963556	33963557	5467	hg38	N/A	enh105014	N/A	Enhatls110661	enhancer	E97	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.235	0.017115		RALY	chr20	33993645	34084884	27617	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1928
enhrx-34398	chr11	127931397	127931398	128061502	128061503	5468	hg38	N/A	N/A	N/A	Enhatls37315	enhancer	E98	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3845	0.017533		ETS1	chr11	128458760	128587558	376091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9067
enhrx-121200	chr3	181556837	181556838	181839049	181839050	5469	hg38	N/A	enh97418	N/A	Enhatls129689	enhancer	E99	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28223	0.018309		SOX2	chr3	181711924	181714436	122522	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9329
enhrx-161139	chr8	116483306	116483307	115471079	115471080	5470	hg38	N/A	N/A	N/A	Enhatls172096	enhancer	E100	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41237	0.01854		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4930
enhrx-120516	chr3	161263697	161263698	161545909	161545910	5471	hg38	N/A	enh82817	N/A	Enhatls128950	enhancer	E101	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.32945	0.019253		OTOL1	chr3	161496807	161503942	41636	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8645
enhrx-34584	chr11	133133439	133133440	133263544	133263545	5472	hg38	N/A	N/A	N/A	Enhatls37526	enhancer	E102	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41631	0.019273		OPCML	chr11	132414976	133532501	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9253
enhrx-121780	chr3	186649706	186649707	186931917	186931918	5473	hg38	N/A	N/A	N/A	Enhatls130321	enhancer	E103	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36777	0.019289		ST6GAL1	chr3	186930525	187078553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9909
enhrx-122026	chr3	193500262	193500263	193782473	193782474	5474	hg38	N/A	enh21239	N/A	Enhatls130592	enhancer	E104	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.42984	0.019291		OPA1	chr3	193593143	193697811	75734	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10155
enhrx-16638	chr1	233609703	233609704	233473957	233473958	5475	hg38	N/A	enh50248	N/A	Enhatls18233	enhancer	E105	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.42984	0.019442		MAP3K21	chr1	233327723	233385148	88627	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16637
enhrx-66237	chr16	85804553	85804554	85770947	85770948	5476	hg38	N/A	N/A	N/A	Enhatls71107	enhancer	E106	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34652	0.019602		EMC8	chr16	85778623	85799608	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6532
enhrx-148094	chr7	13920071	13920072	13880446	13880447	5477	hg38	N/A	enh39890	N/A	Enhatls158262	enhancer	E107	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.16366	0.019776		ETV1	chr7	13891228	13991425	6919	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	906
enhrx-162042	chr8	140775857	140775858	139763614	139763615	5478	hg38	N/A	N/A	N/A	Enhatls173090	enhancer	E108	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31752	0.019806		TRAPPC9	chr8	139727724	140458579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5833
enhrx-82408	chr19	16675809	16675810	16564998	16564999	5479	hg38	N/A	enh32895	N/A	Enhatls88368	enhancer	E109	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.24154	0.020027		SLC35E1	chr19	16549836	16572415	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3378
enhrx-66210	chr16	85548738	85548739	85515132	85515133	5480	hg38	N/A	enh16872	fant51275	Enhatls71076	enhancer	E110	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.32955	0.020271		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-137358	chr5	167787019	167787020	168360014	168360015	5481	hg38	N/A	enh22781	N/A	Enhatls146786	enhancer	E111	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.30617	0.020348		WWC1	chr5	168291644	168472303	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7149
enhrx-29198	chr11	60709912	60709913	60942440	60942441	5482	hg38	N/A	enh96213	N/A	Enhatls31717	enhancer	E112	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20591	0.020539		SLC15A3	chr11	60937059	60952653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3867
enhrx-167149	chr9	113476842	113476843	110714562	110714563	5483	hg38	N/A	enh85500	N/A	Enhatls178896	enhancer	E113	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.4558	0.02086		MUSK	chr9	110668778	110806558	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4416
enhrx-90580	chr2	46170980	46170981	45943841	45943842	5484	hg38	N/A	enh5483	N/A	Enhatls97039	enhancer	E114	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33571	0.02168		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2506
enhrx-121268	chr3	182911725	182911726	183193937	183193938	5485	hg38	N/A	N/A	N/A	Enhatls129762	enhancer	E115	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37722	0.022023		MCF2L2	chr3	183178040	183428778	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9397
enhrx-140542	chr6	34521075	34521076	34553298	34553299	5486	hg38	N/A	N/A	N/A	Enhatls150247	enhancer	E116	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.23891	0.022053		SPDEF	chr6	34537801	34556333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2130
enhrx-158735	chr8	48854668	48854669	47942108	47942109	5487	hg38	N/A	N/A	N/A	Enhatls169572	enhancer	E117	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27023	0.022055		PRKDC	chr8	47773110	47960178	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2526
enhrx-128115	chr4	124264055	124264056	123342900	123342901	5488	hg38	N/A	enh37001	N/A	Enhatls136989	enhancer	E118	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.086984	0.022311		AFG2A	chr4	122923069	123319433	17378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5659
enhrx-16198	chr1	228081766	228081767	227894065	227894066	5489	hg38	N/A	enh12737	N/A	Enhatls17787	enhancer	E119	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.17473	0.022847		WNT9A	chr1	227918655	227947932	20220	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16197
enhrx-140857	chr6	36874603	36874604	36906827	36906828	5490	hg38	N/A	enh49089	N/A	Enhatls150576	enhancer	E120	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.23248	0.02322		C6orf89	chr6	36871869	36928964	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2445
enhrx-29916	chr11	64610743	64610744	64843271	64843272	5491	hg38	N/A	N/A	N/A	Enhatls32485	enhancer	E121	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.13841	0.023792		CDC42BPG	chr11	64823051	64844653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4585
enhrx-121255	chr3	182800251	182800252	183082463	183082464	5492	hg38	N/A	enh93238	N/A	Enhatls129748	enhancer	E122	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.41694	0.023956		MCCC1	chr3	183015217	183116075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9384
enhrx-161447	chr8	124609020	124609021	123596780	123596781	5493	hg38	N/A	enh25266	fant30773	Enhatls172436	enhancer	E123	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27763	0.024005		KLHL38	chr8	123644441	123653801	47602	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5238
enhrx-16902	chr1	236855642	236855643	236692342	236692343	5494	hg38	N/A	N/A	N/A	Enhatls18503	enhancer	E124	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.19387	0.024082		ACTN2	chr1	236664140	236764631	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16901
enhrx-168313	chr9	130361698	130361699	127599419	127599420	5495	hg38	N/A	enh115231	N/A	Enhatls180162	enhancer	E125	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.23743	0.024898		STXBP1	chr9	127579369	127696027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5580
enhrx-11868	chr1	161230948	161230949	161261158	161261159	5496	hg38	N/A	N/A	N/A	Enhatls13149	enhancer	E126	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27042	0.024996		PCP4L1	chr1	161258744	161285450	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11867
enhrx-61606	chr16	17412215	17412216	17318358	17318359	5497	hg38	N/A	enh3921	N/A	Enhatls66215	enhancer	E127	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.24372	0.024996		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-122676	chr4	1546877	1546878	1545150	1545151	5498	hg38	N/A	enh48789	N/A	N/A	enhancer	E128	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26461	0.025378		FAM53A	chr4	1617914	1684313	66752	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	220
enhrx-120898	chr3	172409280	172409281	172691490	172691491	5499	hg38	N/A	enh21118	N/A	Enhatls129367	enhancer	E129	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.43188	0.025519		NCEH1	chr3	172630248	172711218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9027
enhrx-113988	chr3	42586390	42586391	42544898	42544899	5500	hg38	N/A	enh65642	N/A	Enhatls121983	enhancer	E130	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34794	0.025922		SEC22C	chr3	42547968	42601080	846	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2117
enhrx-69959	chr17	30150542	30150543	31823523	31823524	5501	hg38	N/A	enh62606	N/A	Enhatls75097	enhancer	E131	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38214	0.025955		COPRS	chr17	31851870	31859244	23567	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3228
enhrx-121209	chr3	182327530	182327531	182609742	182609743	5502	hg38	N/A	enh54519	N/A	Enhatls129702	enhancer	E132	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.2554	0.026202		ATP11B	chr3	182793502	182921629	181516	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9338
enhrx-105801	chr20	61532311	61532312	62900959	62900960	5503	hg38	N/A	enh6579	N/A	Enhatls113160	enhancer	E133	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.22958	0.026587		DIDO1	chr20	62877737	62937952	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4229
enhrx-131067	chr5	27387802	27387803	27387695	27387696	5504	hg38	N/A	enh93374	N/A	Enhatls140088	enhancer	E134	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.14239	0.026895		CDH9	chr5	26880596	27121150	264529	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	858
enhrx-38250	chr12	51009767	51009768	50615984	50615985	5505	hg38	N/A	enh14708	N/A	Enhatls41409	enhancer	E135	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28908	0.026997		DIP2B	chr12	50504984	50748657	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3560
enhrx-159509	chr8	70805918	70805919	69893683	69893684	5506	hg38	N/A	enh41084	N/A	Enhatls170380	enhancer	E136	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28732	0.027153		SLCO5A1	chr8	69667045	69834978	53153	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3300
enhrx-120653	chr3	167647951	167647952	167930163	167930164	5507	hg38	N/A	N/A	N/A	Enhatls129092	enhancer	E137	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.11246	0.027153		GOLIM4	chr3	168008688	168095924	69352	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8782
enhrx-18059	chr10	11729530	11729531	11687531	11687532	5508	hg38	N/A	enh1111	N/A	Enhatls19742	enhancer	E138	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.107	0.027624		ECHDC3	chr10	11742381	11764070	48746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	494
enhrx-90333	chr2	41369858	41369859	41142718	41142719	5509	hg38	N/A	enh81639	N/A	Enhatls96769	enhancer	E139	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27567	0.027788		SLC8A1	chr2	40097269	40611053	528173	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2259
enhrx-104822	chr20	45344154	45344155	46715515	46715516	5510	hg38	N/A	N/A	N/A	Enhatls112081	enhancer	E140	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28144	0.027994		SLC2A10	chr20	46709648	46736347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3250
enhrx-33964	chr11	121394778	121394779	121524069	121524070	5511	hg38	N/A	N/A	N/A	Enhatls36852	enhancer	E141	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.19819	0.027995		SORL1	chr11	121452313	121633763	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8633
enhrx-160675	chr8	102472526	102472527	101460298	101460299	5512	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E142	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.2844	0.027995		GRHL2	chr8	101492438	101669726	25730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-161139	chr8	116550226	116550227	115537999	115538000	5513	hg38	N/A	enh115048	N/A	Enhatls172096	enhancer	E143	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.031751	0.028057		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4930
enhrx-104053	chr20	36574033	36574034	37945631	37945632	5514	hg38	N/A	N/A	N/A	Enhatls111284	enhancer	E144	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33024	0.028974		VSTM2L	chr20	37903110	37945350	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2481
enhrx-120987	chr3	177167388	177167389	177449600	177449601	5515	hg38	N/A	enh7694	fant14303	Enhatls129465	enhancer	E145	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.22807	0.029241		TBL1XR1	chr3	177019343	177228000	221294	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-94694	chr2	126454392	126454393	125696815	125696816	5516	hg38	N/A	enh96935	N/A	Enhatls101395	enhancer	E146	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27181	0.029501		CNTNAP5	chr2	124025286	124921219	773490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6620
enhrx-146132	chr6	151985709	151985710	151664574	151664575	5517	hg38	N/A	enh84451	N/A	Enhatls156204	enhancer	E147	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35976	0.029503		ESR1	chr6	151690495	152129619	25085	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-103527	chr20	32888161	32888162	34300355	34300356	5518	hg38	N/A	enh70276	N/A	Enhatls110691	enhancer	E148	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38579	0.029971		AHCY	chr20	34280267	34311802	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1955
enhrx-121822	chr3	187526974	187526975	187809186	187809187	5519	hg38	N/A	enh21184	N/A	Enhatls130371	enhancer	E149	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.30055	0.030014		BCL6-AS1	chr3	187743685	187746028	57277	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-105054	chr20	48221239	48221240	49604702	49604703	5520	hg38	N/A	enh19698	fant58957	Enhatls112328	enhancer	E150	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26517	0.030266		B4GALT5	chr20	49632944	49713878	27926	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3482
enhrx-104947	chr20	47562551	47562552	48946014	48946015	5521	hg38	N/A	enh19694	N/A	Enhatls112218	enhancer	E151	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.18061	0.030807		ARFGEF2	chr20	48921710	49036693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3375
enhrx-50782	chr14	68613650	68613651	68146933	68146934	5522	hg38	N/A	enh15707	fant46410	Enhatls54763	enhancer	E152	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.19788	0.031273		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-42832	chr12	116674124	116674125	116236319	116236320	5523	hg38	N/A	N/A	N/A	Enhatls46253	enhancer	E153	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.21811	0.031273		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-27987	chr11	38482609	38482610	38461059	38461060	5524	hg38	N/A	enh28778	N/A	Enhatls30457	enhancer	E154	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3681	0.03242		LRRC4C	chr11	40114202	41459773	1650978	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2656
enhrx-57189	chr15	67440773	67440774	67148435	67148436	5525	hg38	N/A	N/A	fant48605	Enhatls61527	enhancer	E155	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27397	0.032615		SMAD3	chr15	67063762	67195173	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-140879	chr6	36991307	36991308	37023531	37023532	5526	hg38	N/A	enh9089	N/A	Enhatls150612	enhancer	E156	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.12231	0.032615		FGD2	chr6	37005654	37029069	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2467
enhrx-77944	chr18	45660320	45660321	48133949	48133950	5527	hg38	N/A	enh17663	N/A	Enhatls83618	enhancer	E157	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.13647	0.032918		ZBTB7C	chr18	48026671	48410752	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1962
enhrx-2032	chr1	17667151	17667152	17340656	17340657	5528	hg38	N/A	N/A	N/A	Enhatls2281	enhancer	E158	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.076796	0.033146		PADI4	chr1	17308194	17364004	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2031
enhrx-144734	chr6	122160248	122160249	121839102	121839103	5529	hg38	N/A	enh59684	N/A	Enhatls154680	enhancer	E159	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.32834	0.033508		GJA1	chr6	121435594	121449727	386218	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6322
enhrx-23737	chr10	112193740	112193741	110433982	110433983	5530	hg38	N/A	N/A	N/A	Enhatls26055	enhancer	E160	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		0.0066808	0.033704		DUSP5	chr10	110497906	110511533	62120	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6172
enhrx-161142	chr8	116662237	116662238	115650010	115650011	5531	hg38	N/A	enh46629	N/A	Enhatls172100	enhancer	E161	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.24535	0.033704		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4933
enhrx-160418	chr8	97958227	97958228	96945999	96946000	5532	hg38	N/A	enh25138	N/A	Enhatls171351	enhancer	E162	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.22856	0.034187		CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4209
enhrx-80165	chr19	4992201	4992202	4992190	4992191	5533	hg38	N/A	enh4974	N/A	Enhatls86001	enhancer	E163	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.33237	0.034238		KDM4B	chr19	4969112	5153598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1135
enhrx-74310	chr17	72189293	72189294	74193154	74193155	5534	hg38	N/A	enh44488	N/A	Enhatls79785	enhancer	E164	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.48235	0.034292		RPL38	chr17	74203581	74210655	7657	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7579
enhrx-121395	chr3	183803406	183803407	184085618	184085619	5535	hg38	N/A	enh59284	N/A	Enhatls129899	enhancer	E165	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.12204	0.034416		HTR3E	chr3	184097063	184106995	10946	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9524
enhrx-128095	chr4	123693803	123693804	122772648	122772649	5536	hg38	N/A	enh36996	N/A	Enhatls136969	enhancer	E166	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.34048	0.034677		BBS12	chr4	122732701	122744942	27645	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5639
enhrx-40997	chr12	95031662	95031663	94637886	94637887	5537	hg38	N/A	enh14911	N/A	Enhatls44317	enhancer	E167	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.14404	0.034966		TMCC3	chr12	94567121	94650557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6307
enhrx-34768	chr12	619729	619730	510563	510564	5538	hg38	N/A	enh14434	N/A	Enhatls37727	enhancer	E168	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35206	0.035147		B4GALNT3	chr12	459938	563509	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	78
enhrx-152920	chr7	103035002	103035003	103394555	103394556	5539	hg38	N/A	N/A	N/A	Enhatls163425	enhancer	E169	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		0.031843	0.035192		SLC26A5	chr7	103352729	103446207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5732
enhrx-lit75	chr7	139372524	139372525	139687778	139687779	5540	hg38					enhancer	E170	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.079748	0.035379							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-161548	chr8	125539006	125539007	124526765	124526766	5541	hg38	N/A	enh56834	N/A	Enhatls172542	enhancer	E171	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.29792	0.036035		TATDN1	chr8	124488497	124539458	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5339
enhrx-160682	chr8	102595795	102595796	101583567	101583568	5542	hg38	N/A	enh59894	N/A	Enhatls171629	enhancer	E172	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.23676	0.036502		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4473
enhrx-127025	chr4	100753708	100753709	99832551	99832552	5543	hg38	N/A	enh8114	N/A	Enhatls135863	enhancer	E173	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.25767	0.036719		DAPP1	chr4	99816826	99870190	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4569
enhrx-12288	chr1	168601085	168601086	168631847	168631848	5544	hg38	N/A	N/A	N/A	Enhatls13611	enhancer	E174	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.45697	0.036719		XCL1	chr1	168576604	168582069	49649	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12287
enhrx-15739	chr1	222280740	222280741	222107398	222107399	5545	hg38	N/A	enh67291	N/A	Enhatls17282	enhancer	E175	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.22828	0.036751		DUSP10	chr1	221701423	221742089	361095	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15738
enhrx-38482	chr12	52513295	52513296	52119511	52119512	5546	hg38	N/A	enh2356	N/A	Enhatls41649	enhancer	E176	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.30118	0.036945		SMIM41	chr12	52079703	52108255	10565	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3792
enhrx-119342	chr3	136708795	136708796	136989953	136989954	5547	hg38	N/A	N/A	N/A	Enhatls127703	enhancer	E177	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27777	0.036947		IL20RB	chr3	136957982	137011085	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7471
enhrx-107373	chr21	42694611	42694612	41322684	41322685	5548	hg38	N/A	enh34955	N/A	Enhatls114822	enhancer	E178	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.3402	0.036947		FAM3B	chr21	41316800	41357727	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1256
enhrx-13935	chr1	197455074	197455075	197485944	197485945	5549	hg38	N/A	enh95954	N/A	Enhatls15363	enhancer	E179	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.37151	0.03728		CRB1	chr1	197268203	197478455	5441	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13934
enhrx-50782	chr14	68407765	68407766	67941048	67941049	5550	hg38	N/A	enh15706	fant46397	Enhatls54763	enhancer	E180	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.38517	0.037286		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-145618	chr6	139670777	139670778	139349640	139349641	5551	hg38	N/A	enh63595	N/A	Enhatls155651	enhancer	E181	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.107	0.037571		CITED2	chr6	139371806	139374648	19529	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7206
enhrx-160677	chr8	102527923	102527924	101515695	101515696	5552	hg38	N/A	enh58007	N/A	Enhatls171624	enhancer	E182	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.24631	0.037934		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-125539	chr4	71575462	71575463	70709745	70709746	5553	hg38	N/A	enh8000	N/A	Enhatls134302	enhancer	E183	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.16193	0.038437		RUFY3	chr4	70704203	70808619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3083
enhrx-71176	chr17	39695716	39695717	41539464	41539465	5554	hg38	N/A	enh17150	N/A	Enhatls76370	enhancer	E184	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28284	0.038742		KRT19	chr17	41523616	41528308	8198	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4445
enhrx-120284	chr3	156355683	156355684	156637894	156637895	5555	hg38	N/A	enh7651	N/A	Enhatls128695	enhancer	E185	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20416	0.039524		TIPARP	chr3	156673234	156706770	29378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8413
enhrx-20441	chr10	63867105	63867106	62107346	62107347	5556	hg38	N/A	enh1239	N/A	Enhatls22525	enhancer	E186	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.36918	0.039526		ARID5B	chr10	61901683	62096944	2490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2876
enhrx-52536	chr14	98238248	98238249	97771911	97771912	5557	hg38	N/A	enh15919	N/A	Enhatls56664	enhancer	E187	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27364	0.040404		VRK1	chr14	96797303	96935377	830912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4493
enhrx-50692	chr14	68014104	68014105	67547387	67547388	5558	hg38	N/A	enh15699	N/A	Enhatls54670	enhancer	E188	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.15774	0.040758		PLEKHH1	chr14	67533289	67589612	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2649
enhrx-109971	chr22	33176590	33176591	32780604	32780605	5559	hg38	N/A	enh20159	fant61117	Enhatls117676	enhancer	E189	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.19176	0.041443		SYN3	chr22	32507819	33058381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1802
enhrx-135960	chr5	139641066	139641067	140261481	140261482	5560	hg38	N/A	enh22635	N/A	Enhatls145249	enhancer	E190	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.267	0.041961		PFDN1	chr5	140245034	140303113	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5751
enhrx-28512	chr11	47560865	47560866	47539313	47539314	5561	hg38	N/A	enh28824	N/A	Enhatls31019	enhancer	E191	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.21467	0.041961		CELF1	chr11	47465932	47565569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3181
enhrx-121822	chr3	187646655	187646656	187928867	187928868	5562	hg38	N/A	enh7764	N/A	Enhatls130371	enhancer	E192	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.39667	0.042086		BCL6-AS1	chr3	187743685	187746028	173335	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-120946	chr3	174667746	174667747	174949956	174949957	5563	hg38	N/A	enh21127	N/A	Enhatls129418	enhancer	E193	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.29821	0.04211		NAALADL2	chr3	174440986	175810548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9075
enhrx-161911	chr8	134500821	134500822	133488578	133488579	5564	hg38	N/A	enh10577	N/A	Enhatls172948	enhancer	E194	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.27855	0.042427		ST3GAL1	chr8	133454847	133571925	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5702
enhrx-18012	chr10	8114478	8114479	8072515	8072516	5565	hg38	N/A	enh12959	N/A	Enhatls19675	enhancer	E195	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.31363	0.042609		GATA3	chr10	8045377	8075198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	447
enhrx-160677	chr8	102533099	102533100	101520871	101520872	5566	hg38	N/A	enh58008	N/A	Enhatls171624	enhancer	E196	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.30744	0.042979		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-105299	chr20	55258294	55258295	56683238	56683239	5567	hg38	N/A	enh19780	N/A	Enhatls112614	enhancer	E197	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20517	0.04327		TFAP2C	chr20	56629305	56639283	41847	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-3823	chr1	33233010	33233011	32767409	32767410	5568	hg38	N/A	N/A	N/A	Enhatls4235	enhancer	E198	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		0.061998	0.043522		NHSL3	chr1	32741829	32774970	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3822
enhrx-105100	chr20	49190166	49190167	50573629	50573630	5569	hg38	N/A	enh19724	N/A	Enhatls112400	enhancer	E199	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.22911	0.044226		PTPN1	chr20	50510320	50585241	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3528
enhrx-28593	chr11	48077533	48077534	48055981	48055982	5570	hg38	N/A	enh1782	fant38599	Enhatls31101	enhancer	E200	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.26497	0.045168		PTPRJ	chr11	47980424	48170839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3262
enhrx-121946	chr3	192569773	192569774	192851984	192851985	5571	hg38	N/A	enh21231	N/A	Enhatls130504	enhancer	E201	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.16637	0.045316		MB21D2	chr3	192796814	192917856	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10075
enhrx-36681	chr12	24222982	24222983	24070048	24070049	5572	hg38	N/A	enh29440	N/A	Enhatls39762	enhancer	E202	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20016	0.045316		SOX5	chr12	23529503	24562487	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1991
enhrx-135592	chr5	134659699	134659700	135324009	135324010	5573	hg38	N/A	enh45968	N/A	Enhatls144854	enhancer	E203	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28774	0.045316		MACROH2A1	chr5	135334380	135399887	631	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5383
enhrx-161650	chr8	129146419	129146420	128134173	128134174	5574	hg38	N/A	N/A	N/A	Enhatls172664	enhancer	E204	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.35479	0.045318		MYC	chr8	127735433	127742951	389559	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5441
enhrx-131070	chr5	28276209	28276210	28276102	28276103	5575	hg38	N/A	N/A	N/A	Enhatls140093	enhancer	E205	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.19561	0.045779		CDH9	chr5	26880596	27121150	1096299	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	861
enhrx-104417	chr20	42764035	42764036	44135395	44135396	5576	hg38	N/A	enh19646	N/A	Enhatls111667	enhancer	E206	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.2544	0.04622		JPH2	chr20	44106589	44187188	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-109408	chr22	29616456	29616457	29220467	29220468	5577	hg38	N/A	enh97219	N/A	Enhatls117081	enhancer	E207	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.14507	0.047091		EMID1	chr22	29205895	29259597	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1239
enhrx-94583	chr2	121156874	121156875	120399298	120399299	5578	hg38	N/A	enh18844	fant8380	Enhatls101277	enhancer	E208	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.10559	0.047091		INHBB	chr2	120346135	120351803	47478	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-45264	chr13	33234577	33234578	32660440	32660441	5579	hg38	N/A	N/A	N/A	Enhatls48842	enhancer	E209	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.15383	0.047093		PDS5B	chr13	32586451	32778019	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	886
enhrx-15445	chr1	214851878	214851879	214678535	214678536	5580	hg38	N/A	enh79349	N/A	Enhatls16979	enhancer	E210	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.23308	0.047557		CENPF	chr1	214603194	214664571	11892	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15444
enhrx-149729	chr7	46172130	46172131	46132532	46132533	5581	hg38	N/A	N/A	N/A	Enhatls160039	enhancer	E211	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.28583	0.048565		IGFBP3	chr7	45912244	45921874	207304	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-49220	chr14	38058037	38058038	37588832	37588833	5582	hg38	N/A	N/A	N/A	Enhatls53121	enhancer	E212	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.1098	0.048565		FOXA1	chr14	37589551	37595249	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1177
enhrx-104418	chr20	42810877	42810878	44182237	44182238	5583	hg38	N/A	enh19648	N/A	Enhatls111669	enhancer	E213	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.14379	0.048567		JPH2	chr20	44106589	44187188	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2846
enhrx-33529	chr11	118118004	118118005	118247289	118247290	5584	hg38	N/A	enh62213	N/A	Enhatls36385	enhancer	E214	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.16273	0.048817		MPZL3	chr11	118226689	118252365	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8198
enhrx-75473	chr17	78792586	78792587	80818786	80818787	5585	hg38	N/A	enh89887	fant54153	Enhatls81000	enhancer	E215	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.20257	0.049305		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8742
enhrx-122051	chr3	194161636	194161637	194440907	194440908	5586	hg38	N/A	N/A	N/A	Enhatls130629	enhancer	E216	|		|	NA	Strong disruption of cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.48877	0.049749		ATP13A3	chr3	194402673	194487002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10180
enhrx-4733	chr1	41966302	41966303	41500631	41500632	5587	hg38	N/A	enh11789	fant1364	Enhatls5192	enhancer	E217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	direct	Highly Significant	NA		-0.40065	0.050018		HIVEP3	chr1	41506364	41918922	5572	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4732
enhrx-15599	chr1	218671689	218671690	218498347	218498348	5588	hg38	N/A	enh12672	N/A	Enhatls17137	enhancer	E218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25726	0.050203		TGFB2	chr1	218345335	218444619	52322	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15598
enhrx-121861	chr3	189655300	189655301	189937511	189937512	5589	hg38	N/A	enh21214	N/A	Enhatls130414	enhancer	E219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27432	0.050723		P3H2	chr3	189956727	190122437	818	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9990
enhrx-114255	chr3	45698487	45698488	45656995	45656996	5590	hg38	N/A	enh20560	N/A	Enhatls122262	enhancer	E220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19682	0.051143		LIMD1	chr3	45594323	45686341	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2384
enhrx-102480	chr20	14074498	14074499	14093852	14093853	5591	hg38	N/A	enh97108	N/A	Enhatls109577	enhancer	E221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.35878	0.05141		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	908
enhrx-43386	chr12	122582640	122582641	122098093	122098094	5592	hg38	N/A	N/A	N/A	Enhatls46845	enhancer	E222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20559	0.052578		MLXIP	chr12	122078755	122147344	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8696
enhrx-16675	chr1	234709461	234709462	234573715	234573716	5593	hg38	N/A	enh12792	N/A	Enhatls18279	enhancer	E223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1666	0.053024		IRF2BP2	chr1	234604268	234610178	28000	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16674
enhrx-122063	chr3	194275393	194275394	194554664	194554665	5594	hg38	N/A	enh36284	N/A	Enhatls130644	enhancer	E224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26879	0.053675		TMEM44	chr3	194587672	194633689	31327	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10192
enhrx-13237	chr1	182115625	182115626	182146490	182146491	5595	hg38	N/A	enh12436	N/A	Enhatls14609	enhancer	E225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26188	0.053676		ZNF648	chr1	182054569	182061712	84750	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-66549	chr16	89431146	89431147	89364738	89364739	5596	hg38	N/A	enh16906	N/A	Enhatls71455	enhancer	E226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.33842	0.053926		ANKRD11	chr16	89267629	89490561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6844
enhrx-70754	chr17	37404812	37404813	39248559	39248560	5597	hg38	N/A	enh17132	N/A	Enhatls75921	enhancer	E227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28303	0.054078		FBXL20	chr17	39252662	39402523	4081	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4023
enhrx-137623	chr5	171991385	171991386	172564382	172564383	5598	hg38	N/A	enh38668	N/A	Enhatls147084	enhancer	E228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2382	0.054079		NEURL1B	chr5	172641262	172691540	73571	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7414
enhrx-82224	chr19	15523876	15523877	15413065	15413066	5599	hg38	N/A	enh17948	N/A	Enhatls88167	enhancer	E229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089678	0.054079		AKAP8L	chr19	15380049	15419141	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3194
enhrx-34398	chr11	127912259	127912260	128042364	128042365	5600	hg38	N/A	enh43656	N/A	Enhatls37315	enhancer	E230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11482	0.054079		ETS1	chr11	128458760	128587558	416001	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9067
enhrx-41708	chr12	104577023	104577024	104183245	104183246	5601	hg38	N/A	enh14939	N/A	Enhatls45073	enhancer	E231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.41725	0.054264		TXNRD1	chr12	104215778	104350307	29542	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-145680	chr6	143164057	143164058	142842920	142842921	5602	hg38	N/A	enh23726	fant24455	Enhatls155724	enhancer	E232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000298	0.055039		HIVEP2	chr6	142751468	142946365	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7268
enhrx-120967	chr3	175453848	175453849	175736060	175736061	5603	hg38	N/A	N/A	N/A	Enhatls129438	enhancer	E233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27997	0.055116		NAALADL2	chr3	174440986	175810548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9096
enhrx-30645	chr11	67914684	67914685	68147217	68147218	5604	hg38	N/A	enh50865	N/A	Enhatls33316	enhancer	E234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19638	0.055547		KMT5B	chr11	68154862	68213828	2475	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5314
enhrx-128651	chr4	146255148	146255149	145333996	145333997	5605	hg38	N/A	N/A	N/A	Enhatls137551	enhancer	E235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017453	0.055674		OTUD4	chr4	145133648	145180589	137435	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6195
enhrx-121782	chr3	186781783	186781784	187063995	187063996	5606	hg38	N/A	enh48781	N/A	Enhatls130326	enhancer	E236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.36481	0.055988		ST6GAL1	chr3	186930525	187078553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9911
enhrx-15304	chr1	212382477	212382478	212209135	212209136	5607	hg38	N/A	enh12638	N/A	Enhatls16828	enhancer	E237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0050389	0.056167		PPP2R5A	chr1	212285409	212361853	76053	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15303
enhrx-21516	chr10	80986506	80986507	79226749	79226750	5608	hg38	N/A	enh1381	N/A	Enhatls23682	enhancer	E238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085403	0.056374		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3951
enhrx-66210	chr16	85387630	85387631	85354024	85354025	5609	hg38	N/A	N/A	fant51259	Enhatls71076	enhancer	E239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.32567	0.056376		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-41444	chr12	101825606	101825607	101431828	101431829	5610	hg38	N/A	N/A	N/A	Enhatls44784	enhancer	E240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25291	0.056809		ARL1	chr12	101393115	101407772	5671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6754
enhrx-12009	chr1	162816837	162816838	162847047	162847048	5611	hg38	N/A	enh12330	N/A	Enhatls13301	enhancer	E241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16398	0.056809		CCDC190	chr1	162851019	162868761	819	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12008
enhrx-15695	chr1	220509211	220509212	220335869	220335870	5612	hg38	N/A	enh12680	N/A	Enhatls17236	enhancer	E242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25823	0.056809		RAB3GAP2	chr1	220148292	220272529	61235	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15694
enhrx-13120	chr1	180095949	180095950	180126814	180126815	5613	hg38	N/A	enh12420	N/A	Enhatls14486	enhancer	E243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29402	0.056982		CEP350	chr1	179954809	180114875	6520	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13119
enhrx-23348	chr10	104418299	104418300	102658542	102658543	5614	hg38	N/A	N/A	N/A	Enhatls25629	enhancer	E244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25139	0.056984		TRIM8	chr10	102642502	102658318	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5783
enhrx-70884	chr17	38105481	38105482	39949228	39949229	5615	hg38	N/A	enh17136	N/A	Enhatls76049	enhancer	E245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011026	0.057341		LRRC3C	chr17	39927731	39944999	66	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4153
enhrx-146141	chr6	152370270	152370271	152049135	152049136	5616	hg38	N/A	N/A	N/A	Enhatls156212	enhancer	E246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12619	0.057664		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7729
enhrx-33899	chr11	120508044	120508045	120637335	120637336	5617	hg38	N/A	N/A	N/A	Enhatls36784	enhancer	E247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22943	0.057694		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8568
enhrx-149968	chr7	50753591	50753592	50685894	50685895	5618	hg38	N/A	enh24190	N/A	Enhatls160303	enhancer	E248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096734	0.05792		GRB10	chr7	50590062	50793462	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2780
enhrx-174784	chrX	100001011	100001012	100746022	100746023	5619	hg38	N/A	enh85772	N/A	Enhatls186961	enhancer	E249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1325	0.05798		SYTL4	chrX	100671782	100732123	9214	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4501
enhrx-20413	chr10	62939664	62939665	61179906	61179907	5620	hg38	N/A	enh50444	N/A	Enhatls22491	enhancer	E250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27224	0.058174		RHOBTB1	chr10	60869437	61001440	171968	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2848
enhrx-147206	chr7	359051	359052	319085	319086	5621	hg38	N/A	enh46294	N/A	Enhatls157318	enhancer	E251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3694	0.058354		FOXL3	chr7	290169	291488	24751	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	18
enhrx-50784	chr14	68973677	68973678	68506960	68506961	5622	hg38	N/A	enh15715	fant46449	Enhatls54768	enhancer	E252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29141	0.058354		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2741
enhrx-75310	chr17	77967331	77967332	79993532	79993533	5623	hg38	N/A	enh17427	N/A	Enhatls80838	enhancer	E253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30051	0.0584		TBC1D16	chr17	79932342	80035872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8579
enhrx-16590	chr1	232769583	232769584	232633837	232633838	5624	hg38	N/A	enh12786	N/A	Enhatls18181	enhancer	E254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17834	0.058624		SIPA1L2	chr1	232397964	232630516	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16589
enhrx-102423	chr20	13267413	13267414	13286766	13286767	5625	hg38	N/A	enh59060	N/A	Enhatls109519	enhancer	E255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063512	0.058865		ISM1	chr20	13221273	13300651	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	851
enhrx-128690	chr4	147163835	147163836	146242683	146242684	5626	hg38	hs2983	enh21854	N/A	Enhatls137598	enhancer	E256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24898	0.058866		REELD1	chr4	146214514	146232267	8514	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6234
enhrx-119344	chr3	136784407	136784408	137065565	137065566	5627	hg38	N/A	enh63208	N/A	Enhatls127706	enhancer	E257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17352	0.058866		IL20RB	chr3	136957982	137011085	49063	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7473
enhrx-22901	chr10	101039597	101039598	99279840	99279841	5628	hg38	N/A	enh50577	N/A	Enhatls25153	enhancer	E258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24481	0.05891		HPSE2	chr10	98457076	99235862	41827	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5336
enhrx-102536	chr20	16532421	16532422	16551776	16551777	5629	hg38	N/A	enh59072	N/A	Enhatls109635	enhancer	E259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24193	0.059302		KIF16B	chr20	16272103	16573448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	964
enhrx-17610	chr10	659418	659419	613478	613479	5630	hg38	N/A	enh12888	N/A	Enhatls19237	enhancer	E260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23673	0.059808		DIP2C	chr10	274200	689668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	45
enhrx-101710	chr20	1418111	1418112	1437467	1437468	5631	hg38	N/A	enh45056	N/A	Enhatls108773	enhancer	E261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.321	0.060227		NSFL1C	chr20	1442161	1466918	2577	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	138
enhrx-7300	chr1	84395038	84395039	83929355	83929356	5632	hg38	N/A	N/A	N/A	Enhatls7921	enhancer	E262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3924	0.061295		TTLL7	chr1	83865023	83999150	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7299
enhrx-159722	chr8	75978179	75978180	75065944	75065945	5633	hg38	N/A	N/A	N/A	Enhatls170608	enhancer	E263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31438	0.061547		CRISPLD1	chr8	74984504	75034558	96	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3513
enhrx-119808	chr3	143831419	143831420	144112577	144112578	5634	hg38	N/A	N/A	N/A	Enhatls128185	enhancer	E264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021524	0.062089		DIPK2A	chr3	143971822	143992368	119806	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7937
enhrx-116747	chr3	90004502	90004503	89955352	89955353	5635	hg38	N/A	enh97307	N/A	Enhatls124935	enhancer	E265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096142	0.06209		EPHA3	chr3	89107620	89482134	471082	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4876
enhrx-166961	chr9	110280859	110280860	107518578	107518579	5636	hg38	N/A	enh73775	N/A	Enhatls178703	enhancer	E266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035821	0.06209		KLF4	chr9	107484851	107490482	23223	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-95574	chr2	147390961	147390962	146633393	146633394	5637	hg38	N/A	enh33767	N/A	Enhatls102316	enhancer	E267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23295	0.062332		ACVR2A	chr2	147844516	147930826	1207450	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7500
enhrx-46893	chr13	79968184	79968185	79394049	79394050	5638	hg38	N/A	enh2954	N/A	Enhatls50627	enhancer	E268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2069	0.063031		RBM26	chr13	79311823	79406255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2515
enhrx-138594	chr6	3991648	3991649	3991414	3991415	5639	hg38	N/A	enh22924	N/A	Enhatls148165	enhancer	E269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090472	0.063032		PRP4K	chr6	4021299	4064983	27119	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	182
enhrx-41512	chr12	102303210	102303211	101909432	101909433	5640	hg38	N/A	N/A	N/A	Enhatls44857	enhancer	E270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25761	0.063032		DRAM1	chr12	101877579	102012130	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6822
enhrx-132070	chr5	53838371	53838372	54542541	54542542	5641	hg38	N/A	N/A	N/A	Enhatls141152	enhancer	E271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2727	0.063287		SNX18	chr5	54517758	54546586	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1861
enhrx-74228	chr17	70515163	70515164	72519023	72519024	5642	hg38	N/A	enh4581	fant53630	Enhatls79688	enhancer	E272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053108	0.063288		SLC39A11	chr17	72645948	73092712	126705	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-107412	chr21	42850395	42850396	41478468	41478469	5643	hg38	N/A	N/A	N/A	Enhatls114863	enhancer	E273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19724	0.063288		TMPRSS2	chr21	41464299	41531116	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1295
enhrx-66210	chr16	85499778	85499779	85466172	85466173	5644	hg38	N/A	enh16870	fant51274	Enhatls71076	enhancer	E274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30288	0.063288		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-102287	chr20	8962374	8962375	8981727	8981728	5645	hg38	N/A	N/A	N/A	Enhatls109360	enhancer	E275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27059	0.063288		PLCB4	chr20	9067824	9504593	72539	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	715
enhrx-148607	chr7	25155623	25155624	25116004	25116005	5646	hg38	N/A	enh9664	N/A	Enhatls158812	enhancer	E276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21466	0.063612		CYCS	chr7	25118655	25125260	15	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1419
enhrx-34041	chr11	123051475	123051476	123180767	123180768	5647	hg38	N/A	enh14348	N/A	Enhatls36949	enhancer	E277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30908	0.063612		CLMP	chr11	123069871	123195248	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8710
enhrx-37686	chr12	46520357	46520358	46126574	46126575	5648	hg38	N/A	enh14672	N/A	Enhatls40803	enhancer	E278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25428	0.063885		SLC38A1	chr12	46183062	46269951	44531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2996
enhrx-57408	chr15	70755425	70755426	70463086	70463087	5649	hg38	N/A	enh16290	fant48737	Enhatls61772	enhancer	E279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28848	0.064157		UACA	chr15	70654553	70763558	191127	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-16015	chr1	225641998	225641999	225454296	225454297	5650	hg38	N/A	enh950	N/A	Enhatls17577	enhancer	E280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30237	0.064736		LBR	chr1	225401501	225428925	21319	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16014
enhrx-163372	chr9	15401501	15401502	15401503	15401504	5651	hg38	N/A	enh41739	N/A	Enhatls174453	enhancer	E281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081912	0.064769		SNAPC3	chr9	15422733	15465832	19197	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	639
enhrx-27439	chr11	24738136	24738137	24716590	24716591	5652	hg38	N/A	N/A	N/A	Enhatls29888	enhancer	E282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28981	0.06477		LUZP2	chr11	24497052	25082638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2108
enhrx-140743	chr6	36122300	36122301	36154523	36154524	5653	hg38	N/A	enh23188	N/A	Enhatls150458	enhancer	E283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025751	0.064996		MAPK13	chr6	36130483	36144524	2989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2331
enhrx-107881	chr21	46156703	46156704	44736788	44736789	5654	hg38	N/A	enh82373	N/A	Enhatls115364	enhancer	E284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19729	0.065015		TSPEAR	chr21	44497892	44711572	19499	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1764
enhrx-41708	chr12	104565653	104565654	104171875	104171876	5655	hg38	N/A	enh14938	N/A	Enhatls45073	enhancer	E285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25361	0.065469		NFYB	chr12	104117085	104138241	25688	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-105299	chr20	55650446	55650447	57075390	57075391	5656	hg38	N/A	enh19793	N/A	Enhatls112614	enhancer	E286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21501	0.065471		BMP7	chr20	57168752	57266641	85654	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-60721	chr16	4110159	4110160	4060158	4060159	5657	hg38	N/A	enh96654	N/A	Enhatls65290	enhancer	E287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1737	0.065471		ADCY9	chr16	3953386	4116442	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1016
enhrx-140542	chr6	34514652	34514653	34546875	34546876	5658	hg38	N/A	enh63528	fant22322	Enhatls150247	enhancer	E288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30509	0.066909		SPDEF	chr6	34537801	34556333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2130
enhrx-121833	chr3	188495442	188495443	188777654	188777655	5659	hg38	N/A	enh36247	N/A	Enhatls130384	enhancer	E289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3134	0.067089		LPP	chr3	188153283	188890671	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9962
enhrx-168209	chr9	129233798	129233799	126471519	126471520	5660	hg38	N/A	enh42305	N/A	Enhatls180044	enhancer	E290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29946	0.06709		MVB12B	chr9	126326828	126507040	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5476
enhrx-104705	chr20	44624379	44624380	45995740	45995741	5661	hg38	N/A	enh19661	N/A	Enhatls111964	enhancer	E291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10794	0.06709		MMP9	chr20	46008907	46016561	10498	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3133
enhrx-147385	chr7	2233136	2233137	2193501	2193502	5662	hg38	N/A	N/A	N/A	Enhatls157510	enhancer	E292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029513	0.06709		MAD1L1	chr7	1815793	2233243	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	197
enhrx-43847	chr12	124845000	124845001	124360454	124360455	5663	hg38	N/A	enh2670	N/A	Enhatls47327	enhancer	E293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28916	0.067414		NCOR2	chr12	124324414	124567612	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9157
enhrx-168218	chr9	129553983	129553984	126791704	126791705	5664	hg38	N/A	enh26012	N/A	Enhatls180053	enhancer	E294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17888	0.067596		ZBTB43	chr9	126805005	126838210	5450	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5485
enhrx-161447	chr8	124631950	124631951	123619710	123619711	5665	hg38	N/A	enh25267	N/A	Enhatls172436	enhancer	E295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037269	0.067792		KLHL38	chr8	123644441	123653801	19107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5238
enhrx-133258	chr5	75933535	75933536	76637710	76637711	5666	hg38	N/A	N/A	N/A	Enhatls142378	enhancer	E296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20707	0.067838		IQGAP2	chr5	76403284	76708132	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3049
enhrx-159016	chr8	59043098	59043099	58130539	58130540	5667	hg38	N/A	enh25014	N/A	Enhatls169862	enhancer	E297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26707	0.068696		FAM110B	chr8	57994522	58148788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2807
enhrx-121715	chr3	186144336	186144337	186426547	186426548	5668	hg38	N/A	enh63251	N/A	Enhatls130247	enhancer	E298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22355	0.068696		DGKG	chr3	186147200	186362234	61623	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9844
enhrx-104270	chr20	40020654	40020655	41392014	41392015	5669	hg38	N/A	enh62991	N/A	Enhatls111518	enhancer	E299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17185	0.068698		CHD6	chr20	41402082	41618377	6376	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2698
enhrx-71233	chr17	39940773	39940774	41784521	41784522	5670	hg38	N/A	N/A	N/A	Enhatls76431	enhancer	E300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12759	0.068712		JUP	chr17	41754603	41786931	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4502
enhrx-121822	chr3	187498956	187498957	187781168	187781169	5671	hg38	N/A	enh7761	N/A	Enhatls130371	enhancer	E301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21239	0.068712		BCL6-AS1	chr3	187743685	187746028	31859	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-72386	chr17	47178773	47178774	49101411	49101412	5672	hg38	N/A	enh17201	N/A	Enhatls77696	enhancer	E302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19051	0.069003		B4GALNT2	chr17	49132459	49176840	18287	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5655
enhrx-15843	chr1	223915391	223915392	223727689	223727690	5673	hg38	N/A	enh12712	N/A	Enhatls17392	enhancer	E303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19965	0.069003		CAPN2	chr1	223701592	223776018	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15842
enhrx-91409	chr2	65536885	65536886	65309751	65309752	5674	hg38	N/A	enh18615	N/A	Enhatls97950	enhancer	E304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2025	0.069003		SPRED2	chr2	65310850	65432637	990	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3335
enhrx-71289	chr17	40125099	40125100	41973081	41973082	5675	hg38	N/A	N/A	N/A	Enhatls76489	enhancer	E305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12595	0.069003		CNP	chr17	41966762	41977740	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4558
enhrx-104116	chr20	37037570	37037571	38408923	38408924	5676	hg38	N/A	N/A	N/A	Enhatls111358	enhancer	E306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17599	0.069003		LBP	chr20	38346481	38377013	20356	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2544
enhrx-37845	chr12	48395931	48395932	48002148	48002149	5677	hg38	N/A	N/A	fant41627	Enhatls40983	enhancer	E307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2541	0.069004		COL2A1	chr12	47972966	48004506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3155
enhrx-173900	chrX	73669367	73669368	74449532	74449533	5678	hg38	N/A	enh42660	N/A	Enhatls186080	enhancer	E308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15135	0.06908		SLC16A2	chrX	74421492	74533916	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3617
enhrx-42832	chr12	116599479	116599480	116161674	116161675	5679	hg38	N/A	enh30006	N/A	Enhatls46253	enhancer	E309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22015	0.069415		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-150360	chr7	70036554	70036555	70571568	70571569	5680	hg38	N/A	enh40252	N/A	Enhatls160736	enhancer	E310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23905	0.069757		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3172
enhrx-140709	chr6	35887804	35887805	35920027	35920028	5681	hg38	N/A	N/A	N/A	Enhatls150422	enhancer	E311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29182	0.069757		SRPK1	chr6	35832965	35921147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2297
enhrx-7442	chr1	86010496	86010497	85544813	85544814	5682	hg38	N/A	enh26924	fant2200	Enhatls8068	enhancer	E312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17743	0.069757		DDAH1	chr1	85318480	85578363	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7441
enhrx-155347	chr7	145096071	145096072	145398978	145398979	5683	hg38	N/A	enh84866	N/A	Enhatls165974	enhancer	E313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076217	0.070242		TPK1	chr7	144451940	144836395	560518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8159
enhrx-120982	chr3	176802599	176802600	177084811	177084812	5684	hg38	N/A	enh97415	N/A	Enhatls129460	enhancer	E314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.32747	0.070583		TBL1XR1	chr3	177019343	177228000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9111
enhrx-30202	chr11	65756638	65756639	65989167	65989168	5685	hg38	N/A	enh1829	N/A	Enhatls32829	enhancer	E315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24064	0.071206		SART1	chr11	65961733	65980137	4398	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4871
enhrx-42845	chr12	117211172	117211173	116773367	116773368	5686	hg38	N/A	enh80401	N/A	Enhatls46269	enhancer	E316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097923	0.071606		RNFT2	chr12	116738290	116853631	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8155
enhrx-145622	chr6	139760113	139760114	139438976	139438977	5687	hg38	N/A	enh9397	N/A	Enhatls155653	enhancer	E317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29201	0.071746		CITED2	chr6	139371806	139374648	56961	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7210
enhrx-105367	chr20	56620084	56620085	58045028	58045029	5688	hg38	N/A	enh34722	N/A	Enhatls112687	enhancer	E318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20631	0.071843		CIMIP1	chr20	58150901	58161150	100523	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3795
enhrx-20507	chr10	65472121	65472122	63712361	63712362	5689	hg38	N/A	enh1253	N/A	Enhatls22596	enhancer	E319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3326	0.073022		REEP3	chr10	63521400	63625128	82518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2942
enhrx-121541	chr3	184267059	184267060	184549271	184549272	5690	hg38	N/A	enh110105	N/A	Enhatls130049	enhancer	E320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089767	0.073696		EPHB3	chr3	184561784	184582408	9738	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9670
enhrx-149363	chr7	41085351	41085352	41045753	41045754	5691	hg38	N/A	enh40108	N/A	Enhatls159637	enhancer	E321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3033	0.074561		SUGCT	chr7	40135004	40860763	182849	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2175
enhrx-148635	chr7	26555269	26555270	26515650	26515651	5692	hg38	N/A	enh89098	N/A	Enhatls158851	enhancer	E322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24522	0.074562		SNX10	chr7	26291861	26374383	138964	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1447
enhrx-43821	chr12	124615413	124615414	124130867	124130868	5693	hg38	N/A	enh68305	N/A	Enhatls47302	enhancer	E323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20483	0.074665		RFLNA	chr12	123973240	124316024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9131
enhrx-9576	chr1	119369440	119369441	118826817	118826818	5694	hg38	N/A	N/A	N/A	Enhatls10345	enhancer	E324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19583	0.074769		TBX15	chr1	118883045	118989556	47069	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9575
enhrx-32125	chr11	91665782	91665783	91932616	91932617	5695	hg38	N/A	enh115477	N/A	Enhatls34895	enhancer	E325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11696	0.074771		FAT3	chr11	92224817	92896473	290412	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6794
enhrx-16681	chr1	235030267	235030268	234894520	234894521	5696	hg38	N/A	enh12797	N/A	Enhatls18291	enhancer	E326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17583	0.074771		TOMM20	chr1	235109340	235128837	210547	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-33552	chr11	118237275	118237276	118366560	118366561	5697	hg38	N/A	N/A	N/A	Enhatls36411	enhancer	E327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046575	0.074771		UBE4A	chr11	118359599	118399211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8221
enhrx-16336	chr1	229357402	229357403	229221655	229221656	5698	hg38	N/A	enh12764	fant5158	Enhatls17929	enhancer	E328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27327	0.075021		RAB4A	chr1	229271061	229305894	48903	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16335
enhrx-51583	chr14	78057276	78057277	77590933	77590934	5699	hg38	N/A	enh3344	N/A	Enhatls55639	enhancer	E329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23894	0.075172		SPTLC2	chr14	77505996	77616637	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3540
enhrx-74002	chr17	66436213	66436214	68440072	68440073	5700	hg38	N/A	enh4559	N/A	Enhatls79440	enhancer	E330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26347	0.075176		WIPI1	chr17	68421280	68457496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7271
enhrx-144350	chr6	111975415	111975416	111654212	111654213	5701	hg38	N/A	enh9321	N/A	Enhatls154270	enhancer	E331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17243	0.075177		FYN	chr6	111660331	111873452	808	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5938
enhrx-122026	chr3	193462030	193462031	193744241	193744242	5702	hg38	N/A	enh21238	N/A	Enhatls130592	enhancer	E332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3437	0.075177		OPA1	chr3	193593143	193697811	42665	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10155
enhrx-171970	chrX	39952404	39952405	40093151	40093152	5703	hg38	N/A	enh11181	N/A	Enhatls184012	enhancer	E333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19336	0.075177		BCOR	chrX	40049814	40177329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1687
enhrx-66354	chr16	88454915	88454916	88388507	88388508	5704	hg38	N/A	enh57695	N/A	N/A	enhancer	E334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15702	0.075485		ZNF469	chr16	88382958	88440757	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6649
enhrx-136212	chr5	143567469	143567470	144187906	144187907	5705	hg38	N/A	enh8768	fant20201	Enhatls145527	enhancer	E335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.35611	0.075519		KCTD16	chr5	144170872	144485686	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6003
enhrx-10556	chr1	153336838	153336839	153364362	153364363	5706	hg38	N/A	enh12267	N/A	Enhatls11761	enhancer	E336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23918	0.076593		S100A9	chr1	153357853	153361023	2	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10555
enhrx-38980	chr12	54981215	54981216	54587431	54587432	5707	hg38	N/A	N/A	N/A	Enhatls42167	enhancer	E337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22693	0.076595		PPP1R1A	chr12	54575386	54588659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4290
enhrx-57408	chr15	70809723	70809724	70517384	70517385	5708	hg38	N/A	enh62493	N/A	Enhatls61772	enhancer	E338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30724	0.077259		UACA	chr15	70654553	70763558	133814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-131317	chr5	35468873	35468874	35468771	35468772	5709	hg38	N/A	enh22135	N/A	Enhatls140362	enhancer	E339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2167	0.077725		SPEF2	chr5	35617843	35814611	144711	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1108
enhrx-38860	chr12	54198395	54198396	53804611	53804612	5710	hg38	N/A	enh80200	N/A	Enhatls42043	enhancer	E340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19012	0.077922		CALCOCO1	chr12	53708516	53727745	64477	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-14543	chr1	204071362	204071363	204102234	204102235	5711	hg38	N/A	enh12573	N/A	Enhatls16009	enhancer	E341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26127	0.077922		SOX13	chr1	204073114	204127743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14542
enhrx-147962	chr7	7805349	7805350	7765718	7765719	5712	hg38	N/A	enh49220	N/A	Enhatls158119	enhancer	E342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062904	0.07803		UMAD1	chr7	7640751	7968020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	774
enhrx-21375	chr10	76754949	76754950	74995191	74995192	5713	hg38	N/A	enh79666	N/A	Enhatls23511	enhancer	E343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019057	0.079528		KAT6B	chr10	74824926	75032624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3810
enhrx-4843	chr1	43397620	43397621	42931949	42931950	5714	hg38	N/A	enh296	N/A	Enhatls5312	enhancer	E344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22699	0.080685		SLC2A1	chr1	42925352	42958868	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4842
enhrx-66077	chr16	84140157	84140158	84106552	84106553	5715	hg38	N/A	N/A	N/A	Enhatls70929	enhancer	E345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15929	0.080685		MBTPS1	chr16	84053762	84116942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6372
enhrx-14606	chr1	204448941	204448942	204479813	204479814	5716	hg38	N/A	enh12585	N/A	Enhatls16094	enhancer	E346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22524	0.080685		PIK3C2B	chr1	204422627	204494805	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14605
enhrx-116455	chr3	71076252	71076253	71027101	71027102	5717	hg38	N/A	enh59197	N/A	Enhatls124620	enhancer	E347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16124	0.081285		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4584
enhrx-131434	chr5	36388439	36388440	36388337	36388338	5718	hg38	N/A	enh22139	N/A	Enhatls140485	enhancer	E348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0071789	0.082621		RANBP3L	chr5	36246912	36302114	83810	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1225
enhrx-75033	chr17	75947464	75947465	77951382	77951383	5719	hg38	N/A	enh96772	N/A	Enhatls80539	enhancer	E349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12356	0.083256		TNRC6C	chr17	77958702	78108822	5230	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8302
enhrx-34547	chr11	130492354	130492355	130622459	130622460	5720	hg38	N/A	enh14409	N/A	Enhatls37482	enhancer	E350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037363	0.083493		ADAMTS15	chr11	130448644	130476645	145386	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9216
enhrx-111474	chr22	46883334	46883335	46487437	46487438	5721	hg38	N/A	enh20265	N/A	Enhatls119297	enhancer	E351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18951	0.083522		CELSR1	chr22	46360833	46537620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3305
enhrx-107362	chr21	42259030	42259031	40887104	40887105	5722	hg38	N/A	enh97210	N/A	Enhatls114808	enhancer	E352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16068	0.08373		DSCAM	chr21	40010998	40847158	37822	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1245
enhrx-62249	chr16	22671564	22671565	22660243	22660244	5723	hg38	N/A	N/A	N/A	Enhatls66875	enhancer	E353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20873	0.08373		NPIPB5	chr16	22490336	22536535	110850	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2544
enhrx-120986	chr3	176997124	176997125	177279336	177279337	5724	hg38	N/A	enh21133	N/A	Enhatls129462	enhancer	E354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.33174	0.084141		TBL1XR1	chr3	177019343	177228000	46718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9115
enhrx-160755	chr8	103524094	103524095	102511866	102511867	5725	hg38	N/A	enh73429	N/A	Enhatls171706	enhancer	E355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.41106	0.084141		ODF1	chr8	102551588	102561018	37682	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4546
enhrx-31800	chr11	83048303	83048304	83337260	83337261	5726	hg38	N/A	N/A	N/A	Enhatls34554	enhancer	E356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31462	0.084141		CCDC90B	chr11	83259080	83286390	35280	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6469
enhrx-982	chr1	8964138	8964139	8904079	8904080	5727	hg38	N/A	enh11478	fant286	Enhatls1056	enhancer	E357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20857	0.084141		ENO1	chr1	8860999	8879190	24803	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	981
enhrx-100068	chr2	224432446	224432447	223567728	223567729	5728	hg38	N/A	N/A	N/A	Enhatls107062	enhancer	E358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040279	0.084143		SCG2	chr2	223596939	223602361	22491	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11994
enhrx-73197	chr17	57864084	57864085	59786723	59786724	5729	hg38	hs2068	enh4506	fant53199	Enhatls78579	enhancer	E359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13362	0.084342		VMP1	chr17	59707516	59842255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6466
enhrx-73201	chr17	57929466	57929467	59852105	59852106	5730	hg38	N/A	enh17263	N/A	Enhatls78584	enhancer	E360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1798	0.084354		TUBD1	chr17	59859478	59892945	6214	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6470
enhrx-11219	chr1	156664148	156664149	156694356	156694357	5731	hg38	N/A	enh43056	fant3285	Enhatls12487	enhancer	E361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27518	0.084354		CRABP2	chr1	156699605	156705816	5231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11218
enhrx-37808	chr12	48339031	48339032	47945248	47945249	5732	hg38	N/A	N/A	N/A	Enhatls40946	enhancer	E362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07491	0.084354		VDR	chr12	47841536	47943048	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3118
enhrx-70032	chr17	30626185	30626186	32299166	32299167	5733	hg38	N/A	N/A	N/A	Enhatls75169	enhancer	E363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17854	0.084356		RHBDL3	chr17	32265831	32324659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3301
enhrx-75471	chr17	78725495	78725496	80751695	80751696	5734	hg38	N/A	enh4636	N/A	Enhatls80994	enhancer	E364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092492	0.084356		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-11584	chr1	159884282	159884283	159914492	159914493	5735	hg38	N/A	enh61913	N/A	Enhatls12863	enhancer	E365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092109	0.084912		TAGLN2	chr1	159918106	159925507	1671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11583
enhrx-7001	chr1	75118335	75118336	74652651	74652652	5736	hg38	N/A	enh419	N/A	Enhatls7608	enhancer	E366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24714	0.085015		ERICH3	chr1	74568122	74673792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7000
enhrx-42832	chr12	116638824	116638825	116201019	116201020	5737	hg38	N/A	enh30009	N/A	Enhatls46253	enhancer	E367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21478	0.085296		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-145372	chr6	135592506	135592507	135271368	135271369	5738	hg38	N/A	enh23640	N/A	Enhatls155369	enhancer	E368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16735	0.085333		AHI1	chr6	135283406	135498434	10070	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6960
enhrx-41133	chr12	96657345	96657346	96263567	96263568	5739	hg38	N/A	enh64624	N/A	Enhatls44462	enhancer	E369	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20065	0.085606		ELK3	chr12	96194374	96269824	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6443
enhrx-94676	chr2	125324293	125324294	124566716	124566717	5740	hg38	N/A	enh92930	N/A	Enhatls101377	enhancer	E370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025456	0.087367		CNTNAP5	chr2	124025286	124921219	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6602
enhrx-75191	chr17	76732026	76732027	78735944	78735945	5741	hg38	N/A	N/A	N/A	Enhatls80721	enhancer	E371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.32591	0.087634		CYTH1	chr17	78674047	78782297	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8460
enhrx-51258	chr14	74980531	74980532	74513828	74513829	5742	hg38	N/A	enh15768	N/A	Enhatls55273	enhancer	E372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10328	0.087988		LTBP2	chr14	74498182	74612237	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3215
enhrx-131862	chr5	43151014	43151015	43150912	43150913	5743	hg38	N/A	enh37781	N/A	Enhatls140943	enhancer	E373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08741	0.088361		ZNF131	chr5	43068056	43176324	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1653
enhrx-141945	chr6	49858880	49858881	49891167	49891168	5744	hg38	N/A	enh55781	fant22885	Enhatls151749	enhancer	E374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23878	0.088692		CRISP1	chr6	49834256	49877096	13959	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3533
enhrx-156714	chr8	11602599	11602600	11745090	11745091	5745	hg38	N/A	enh10169	N/A	Enhatls167414	enhancer	E375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.37399	0.089737		GATA4	chr8	11676958	11760002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-121292	chr3	183099259	183099260	183381471	183381472	5746	hg38	N/A	enh7725	N/A	Enhatls129790	enhancer	E376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15393	0.090216		MCF2L2	chr3	183178040	183428778	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9421
enhrx-153086	chr7	105471049	105471050	105830603	105830604	5747	hg38	N/A	enh24397	N/A	Enhatls163604	enhancer	E377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31457	0.090218		ATXN7L1	chr7	105604771	105876599	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5898
enhrx-161913	chr8	134781336	134781337	133769093	133769094	5748	hg38	N/A	enh41611	N/A	Enhatls172951	enhancer	E378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24588	0.090387		ST3GAL1	chr8	133454847	133571925	192763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5704
enhrx-66210	chr16	85525796	85525797	85492190	85492191	5749	hg38	N/A	enh16871	N/A	Enhatls71076	enhancer	E379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22173	0.090387		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-120987	chr3	177077878	177077879	177360090	177360091	5750	hg38	N/A	enh7693	fant14297	Enhatls129464	enhancer	E380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1686	0.090387		TBL1XR1	chr3	177019343	177228000	131713	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-70798	chr17	37730398	37730399	39574145	39574146	5751	hg38	N/A	enh89862	N/A	Enhatls75964	enhancer	E381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27298	0.090388		NEUROD2	chr17	39603767	39607920	27383	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4067
enhrx-1072	chr1	9903688	9903689	9843630	9843631	5752	hg38	N/A	enh42876	N/A	Enhatls1166	enhancer	E382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19504	0.090388		CTNNBIP1	chr1	9848275	9910336	4220	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1071
enhrx-15372	chr1	213154633	213154634	212981291	212981292	5753	hg38	N/A	enh27475	N/A	Enhatls16898	enhancer	E383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22151	0.091022		VASH2	chr1	212950519	212991585	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15371
enhrx-106744	chr21	33712171	33712172	32339862	32339863	5754	hg38	N/A	N/A	N/A	Enhatls114133	enhancer	E384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078316	0.091212		URB1	chr21	32311017	32393012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	627
enhrx-14295	chr1	202076804	202076805	202107676	202107677	5755	hg38	N/A	enh12535	N/A	Enhatls15738	enhancer	E385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2552	0.091213		GPR37L1	chr1	202122885	202133592	14378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14294
enhrx-128251	chr4	129646836	129646837	128725681	128725682	5756	hg38	N/A	enh54986	N/A	Enhatls137134	enhancer	E386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22858	0.091573		JADE1	chr4	128809699	128875224	79820	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5795
enhrx-77668	chr18	39246370	39246371	41666406	41666407	5757	hg38	N/A	N/A	N/A	Enhatls83330	enhancer	E387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16384	0.09262		PIK3C3	chr18	41955233	42087830	253367	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1686
enhrx-142246	chr6	55889876	55889877	56025078	56025079	5758	hg38	N/A	enh77895	N/A	Enhatls152069	enhancer	E388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042795	0.092797		COL21A1	chr6	56056589	56394094	28533	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3834
enhrx-106713	chr21	33248891	33248892	31876578	31876579	5759	hg38	N/A	N/A	N/A	Enhatls114099	enhancer	E389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095533	0.093204		HUNK	chr21	31873019	32044633	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	596
enhrx-147962	chr7	7802337	7802338	7762706	7762707	5760	hg38	N/A	enh49220	N/A	Enhatls158119	enhancer	E390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078637	0.093204		UMAD1	chr7	7640751	7968020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	774
enhrx-66170	chr16	84868202	84868203	84834596	84834597	5761	hg38	N/A	enh16855	N/A	Enhatls71027	enhancer	E391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25846	0.093392		CRISPLD2	chr16	84819984	84909508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6465
enhrx-160677	chr8	102551374	102551375	101539146	101539147	5762	hg38	N/A	enh25183	N/A	Enhatls171624	enhancer	E392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25913	0.093887		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-104587	chr20	44077115	44077116	45448475	45448476	5763	hg38	N/A	N/A	N/A	Enhatls111841	enhancer	E393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31793	0.094213		PIGT	chr20	45416083	45448578	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3015
enhrx-107185	chr21	39083106	39083107	37710804	37710805	5764	hg38	N/A	enh65520	N/A	Enhatls114617	enhancer	E394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12656	0.094605		KCNJ6	chr21	37607372	38121345	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1068
enhrx-9452	chr1	117563469	117563470	117020847	117020848	5765	hg38	N/A	N/A	N/A	Enhatls10217	enhancer	E395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028921	0.094606		CD101	chr1	117001749	117036552	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9451
enhrx-61603	chr16	17265275	17265276	17171418	17171419	5766	hg38	N/A	enh16577	N/A	Enhatls66212	enhancer	E396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18549	0.094606		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1898
enhrx-94915	chr2	129338839	129338840	128581265	128581266	5767	hg38	N/A	enh53300	N/A	Enhatls101626	enhancer	E397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23644	0.09476		HS6ST1	chr2	128265479	128318868	258304	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6841
enhrx-13363	chr1	183232122	183232123	183262987	183262988	5768	hg38	N/A	enh12448	N/A	Enhatls14752	enhancer	E398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25316	0.09476		NMNAT2	chr1	183248236	183418380	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13362
enhrx-140775	chr6	36302950	36302951	36335173	36335174	5769	hg38	N/A	N/A	fant22393	Enhatls150491	enhancer	E399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18049	0.095657		BNIP5	chr6	36315760	36336888	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2363
enhrx-158373	chr8	40314797	40314798	40457278	40457279	5770	hg38	N/A	enh114823	N/A	Enhatls169206	enhancer	E400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31169	0.096646		ZMAT4	chr8	40530589	40897833	69294	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-36302	chr12	16090994	16090995	15938060	15938061	5771	hg38	N/A	N/A	N/A	Enhatls39372	enhancer	E401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15758	0.097993		DERA	chr12	15911328	16037381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1612
enhrx-158840	chr8	53252949	53252950	52340389	52340390	5772	hg38	N/A	enh56674	N/A	Enhatls169684	enhancer	E402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2628	0.097995		ST18	chr8	52110837	52409805	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2631
enhrx-40192	chr12	71276014	71276015	70882234	70882235	5773	hg38	N/A	N/A	N/A	Enhatls43451	enhancer	E403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097044	0.098518		PTPRR	chr12	70638072	70920738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5502
enhrx-15599	chr1	218633891	218633892	218460549	218460550	5774	hg38	hs2536	enh27510	N/A	Enhatls17137	enhancer	E404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052769	0.10041		TGFB2	chr1	218345335	218444619	15670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15598
enhrx-38763	chr12	53673871	53673872	53280087	53280088	5775	hg38	N/A	N/A	N/A	Enhatls41942	enhancer	E405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19395	0.1005		ESPL1	chr12	53268298	53293638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-44652	chr13	24062844	24062845	23488705	23488706	5776	hg38	N/A	enh80437	fant43881	Enhatls48179	enhancer	E406	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010329	0.10117		SACS	chr13	23288688	23433752	54759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	274
enhrx-157974	chr8	33279653	33279654	33422135	33422136	5777	hg38	N/A	enh94729	N/A	Enhatls168779	enhancer	E407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063013	0.10117		FUT10	chr8	33370823	33473146	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1765
enhrx-169564	chr9	137699752	137699753	134807906	134807907	5778	hg38	N/A	enh102888	N/A	Enhatls181483	enhancer	E408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11759	0.10167		COL5A1	chr9	134641802	134844843	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6831
enhrx-138895	chr6	11226466	11226467	11226233	11226234	5779	hg38	N/A	enh23016	N/A	Enhatls148491	enhancer	E409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072838	0.10167		NEDD9	chr6	11183297	11382348	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	483
enhrx-171960	chrX	39436563	39436564	39577309	39577310	5780	hg38	N/A	enh47005	N/A	Enhatls184001	enhancer	E410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11944	0.10175		BCOR	chrX	40049814	40177329	465434	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1677
enhrx-41270	chr12	100535817	100535818	100142039	100142040	5781	hg38	N/A	N/A	fant42853	Enhatls44605	enhancer	E411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26198	0.10186		BLTP3B	chr12	100028454	100142874	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6580
enhrx-30839	chr11	70058532	70058533	70212426	70212427	5782	hg38	N/A	enh14042	N/A	Enhatls33532	enhancer	E412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1761	0.10186		FADD	chr11	70203295	70207390	15	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5508
enhrx-59857	chr16	643614	643615	593614	593615	5783	hg38	N/A	enh16491	fant49652	Enhatls64404	enhancer	E413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29541	0.10224		RAB40C	chr16	589356	629271	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	152
enhrx-30788	chr11	69330226	69330227	69515458	69515459	5784	hg38	N/A	enh28854	N/A	Enhatls33476	enhancer	E414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27941	0.10313		CCND1	chr11	69641155	69654474	123444	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5457
enhrx-161618	chr8	126464465	126464466	125452223	125452224	5785	hg38	N/A	enh25292	N/A	Enhatls172611	enhancer	E415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18522	0.10313		TRIB1	chr8	125430357	125438403	11605	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5409
enhrx-17723	chr10	3867711	3867712	3825519	3825520	5786	hg38	N/A	enh12922	fant34431	Enhatls19362	enhancer	E416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21302	0.10313		KLF6	chr10	3775995	3785281	40019	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	158
enhrx-150675	chr7	73879400	73879401	74465070	74465071	5787	hg38	N/A	enh49275	N/A	Enhatls161057	enhancer	E417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070459	0.10313		GTF2IRD1	chr7	74453789	74602605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3487
enhrx-140543	chr6	34535228	34535229	34567451	34567452	5788	hg38	N/A	enh86619	N/A	Enhatls150248	enhancer	E418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1619	0.10313		SPDEF	chr6	34537801	34556333	5001	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2131
enhrx-125024	chr4	57276572	57276573	56410406	56410407	5789	hg38	N/A	N/A	fant15837	Enhatls133769	enhancer	E419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14484	0.10313		PPAT	chr4	56393361	56435615	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2568
enhrx-52433	chr14	96016761	96016762	95550424	95550425	5790	hg38	N/A	enh15903	N/A	Enhatls56545	enhancer	E420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24665	0.10313		GLRX5	chr14	95535049	95544724	3271	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4390
enhrx-11608	chr1	160031398	160031399	160061608	160061609	5791	hg38	N/A	enh102246	N/A	Enhatls12885	enhancer	E421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17476	0.10313		KCNJ10	chr1	159998650	160070160	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11607
enhrx-101859	chr20	2749151	2749152	2768505	2768506	5792	hg38	N/A	enh62940	N/A	Enhatls108918	enhancer	E422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17473	0.10313		EBF4	chr20	2692779	2760108	6252	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	287
enhrx-148635	chr7	26565383	26565384	26525764	26525765	5793	hg38	N/A	N/A	N/A	Enhatls158851	enhancer	E423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1273	0.10338		SKAP2	chr7	26667067	26995239	133957	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1447
enhrx-60991	chr16	8026752	8026753	7976750	7976751	5794	hg38	N/A	N/A	N/A	Enhatls65567	enhancer	E424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31145	0.10396		RBFOX1	chr16	5239801	7713340	247118	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1286
enhrx-22336	chr10	95482512	95482513	93722755	93722756	5795	hg38	N/A	N/A	N/A	Enhatls24566	enhancer	E425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038803	0.10424		FRA10AC1	chr10	93667882	93702592	13053	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4771
enhrx-104624	chr20	44407867	44407868	45779228	45779229	5796	hg38	N/A	enh62995	N/A	Enhatls111879	enhancer	E426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22054	0.10429		WFDC3	chr20	45774207	45791883	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3052
enhrx-160675	chr8	102400594	102400595	101388366	101388367	5797	hg38	N/A	enh25179	N/A	Enhatls171623	enhancer	E427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2412	0.10429		GRHL2	chr8	101492438	101669726	94826	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-98448	chr2	201124445	201124446	200259722	200259723	5798	hg38	N/A	enh34140	N/A	Enhatls105327	enhancer	E428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23519	0.1043		SPATS2L	chr2	200305880	200482264	44029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10374
enhrx-37715	chr12	46886502	46886503	46492719	46492720	5799	hg38	N/A	enh14678	N/A	Enhatls40840	enhancer	E429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23727	0.1043		SLC38A2	chr12	46358187	46372773	105730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3025
enhrx-159174	chr8	63773551	63773552	62860992	62860993	5800	hg38	N/A	N/A	N/A	Enhatls170030	enhancer	E430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13161	0.1043		NKAIN3	chr8	62248590	63014000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2965
enhrx-26558	chr11	9890323	9890324	9868776	9868777	5801	hg38	N/A	enh101241	N/A	Enhatls28955	enhancer	E431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26555	0.1043		SBF2	chr11	9776775	10294227	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1227
enhrx-161138	chr8	116419624	116419625	115407396	115407397	5802	hg38	N/A	N/A	N/A	Enhatls172094	enhancer	E432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20075	0.1048		TRPS1	chr8	115408495	115809673	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4929
enhrx-97062	chr2	173505286	173505287	172640558	172640559	5803	hg38	N/A	enh33956	N/A	Enhatls103884	enhancer	E433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.37836	0.10503		PDK1	chr2	172555372	172608669	28709	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8988
enhrx-21512	chr10	80565215	80565216	78805458	78805459	5804	hg38	N/A	enh13333	N/A	Enhatls23668	enhancer	E434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23421	0.10504		ZMIZ1	chr10	79068965	79316519	259723	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-138902	chr6	11637732	11637733	11637499	11637500	5805	hg38	N/A	enh8950	N/A	Enhatls148498	enhancer	E435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13568	0.10509		TMEM170B	chr6	11537748	11583524	45629	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	490
enhrx-135082	chr5	127270788	127270789	127935096	127935097	5806	hg38	N/A	N/A	N/A	Enhatls144302	enhancer	E436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17852	0.10509		CCDC192	chr5	127703360	127941507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4873
enhrx-152693	chr7	101619037	101619038	101975757	101975758	5807	hg38	N/A	enh9950	N/A	Enhatls163185	enhancer	E437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14092	0.10522		CUX1	chr7	101815903	102283958	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-55600	chr15	46214343	46214344	45922145	45922146	5808	hg38	N/A	enh31347	N/A	Enhatls59819	enhancer	E438	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31438	0.10522		SQOR	chr15	45631147	45691281	225687	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2302
enhrx-124327	chr4	40844715	40844716	40842698	40842699	5809	hg38	N/A	N/A	N/A	Enhatls133047	enhancer	E439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15619	0.10538		APBB2	chr4	40810026	41214618	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1871
enhrx-137280	chr5	161495702	161495703	162068696	162068697	5810	hg38	N/A	N/A	N/A	Enhatls146706	enhancer	E440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22916	0.10541		GABRG2	chr5	162000056	162162977	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7071
enhrx-122093	chr3	194754368	194754369	195033639	195033640	5811	hg38	N/A	enh21264	N/A	Enhatls130677	enhancer	E441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29821	0.10541		XXYLT1	chr3	195068283	195271159	30718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10222
enhrx-42793	chr12	114968395	114968396	114530590	114530591	5812	hg38	N/A	enh96360	N/A	Enhatls46216	enhancer	E442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12429	0.10555		TBX5	chr12	114353910	114408442	118419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8103
enhrx-134637	chr5	114390222	114390223	115054525	115054526	5813	hg38	N/A	N/A	N/A	Enhatls143822	enhancer	E443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1135	0.10555		TRIM36	chr5	115124761	115180546	54094	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4428
enhrx-102352	chr20	10092061	10092062	10111413	10111414	5814	hg38	N/A	enh34519	N/A	Enhatls109427	enhancer	E444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094664	0.10555		ANKEF1	chr20	10034986	10058303	49435	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	780
enhrx-160677	chr8	102516467	102516468	101504239	101504240	5815	hg38	N/A	enh25182	N/A	Enhatls171624	enhancer	E445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24619	0.10555		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-33899	chr11	120497627	120497628	120626918	120626919	5816	hg38	N/A	N/A	N/A	Enhatls36784	enhancer	E446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19656	0.10578		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8568
enhrx-105145	chr20	49604384	49604385	50987847	50987848	5817	hg38	N/A	enh6535	N/A	Enhatls112448	enhancer	E447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29523	0.10579		KCNG1	chr20	51003655	51023107	2338	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3573
enhrx-161189	chr8	118589798	118589799	117577559	117577560	5818	hg38	N/A	N/A	N/A	Enhatls172155	enhancer	E448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13671	0.10588		MED30	chr8	117520712	117540262	4695	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4980
enhrx-150525	chr7	72982408	72982409	73568078	73568079	5819	hg38	N/A	N/A	N/A	Enhatls160906	enhancer	E449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15202	0.10588		TBL2	chr7	73567536	73578791	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3337
enhrx-66210	chr16	85356051	85356052	85322445	85322446	5820	hg38	N/A	enh16866	fant51256	Enhatls71076	enhancer	E450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045444	0.10588		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-7573	chr1	87258916	87258917	86793233	86793234	5821	hg38	N/A	enh26935	fant2229	Enhatls8209	enhancer	E451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16233	0.10588		SH3GLB1	chr1	86704569	86748184	44898	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7572
enhrx-76933	chr18	19638078	19638079	22058117	22058118	5822	hg38	N/A	enh81324	N/A	Enhatls82547	enhancer	E452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25224	0.10588		GATA6	chr18	22169588	22202528	105135	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	951
enhrx-56838	chr15	64312146	64312147	64019947	64019948	5823	hg38	N/A	enh3635	N/A	Enhatls61150	enhancer	E453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16159	0.10599		DAPK2	chr15	63907035	64072033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3540
enhrx-54468	chr15	39897538	39897539	39605337	39605338	5824	hg38	N/A	N/A	N/A	Enhatls58659	enhancer	E454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00052896	0.10599		FSIP1	chr15	39600030	39782841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1170
enhrx-73344	chr17	59413567	59413568	61336206	61336207	5825	hg38	N/A	enh17269	N/A	Enhatls78727	enhancer	E455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25378	0.10599		BCAS3	chr17	60677452	61392838	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6613
enhrx-171960	chrX	39592321	39592322	39733067	39733068	5826	hg38	N/A	enh42555	N/A	Enhatls184001	enhancer	E456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18837	0.10616		BCOR	chrX	40049814	40177329	313534	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1677
enhrx-161142	chr8	116661955	116661956	115649728	115649729	5827	hg38	N/A	enh46629	N/A	Enhatls172100	enhancer	E457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1861	0.10627		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4933
enhrx-27944	chr11	35915838	35915839	35894288	35894289	5828	hg38	N/A	enh13901	N/A	Enhatls30412	enhancer	E458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27728	0.10627		LDLRAD3	chr11	35943980	36232136	47474	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2613
enhrx-161541	chr8	125503611	125503612	124491370	124491371	5829	hg38	N/A	enh91898	N/A	Enhatls172533	enhancer	E459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11039	0.10627		TATDN1	chr8	124488497	124539458	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5332
enhrx-135673	chr5	136477932	136477933	137142243	137142244	5830	hg38	N/A	enh8715	fant19930	Enhatls144945	enhancer	E460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24485	0.10741		SPOCK1	chr5	136975297	137499326	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5464
enhrx-50591	chr14	65585260	65585261	65118542	65118543	5831	hg38	N/A	enh96522	N/A	Enhatls54568	enhancer	E461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2654	0.10741		MAX	chr14	65006173	65102695	13093	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2548
enhrx-60181	chr16	1862954	1862955	1812953	1812954	5832	hg38	N/A	N/A	N/A	Enhatls64730	enhancer	E462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19959	0.10778		HAGH	chr16	1795619	1827157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	476
enhrx-1179	chr1	10568814	10568815	10508757	10508758	5833	hg38	N/A	enh59	N/A	Enhatls1277	enhancer	E463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21701	0.10823		PEX14	chr1	10474949	10630758	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1178
enhrx-lit76	chr5	85861	85862	85746	85747	5834	hg38					enhancer	E464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23444	0.10842							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-3822	chr1	33209562	33209563	32743961	32743962	5835	hg38	N/A	N/A	N/A	Enhatls4234	enhancer	E465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11149	0.10842		NHSL3	chr1	32741829	32774970	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3821
enhrx-23094	chr10	102375879	102375880	100616122	100616123	5836	hg38	N/A	N/A	N/A	Enhatls25355	enhancer	E466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21716	0.10842		HIF1AN	chr10	100529071	100559998	55724	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5529
enhrx-36827	chr12	27044698	27044699	26891765	26891766	5837	hg38	N/A	N/A	N/A	Enhatls39918	enhancer	E467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23764	0.10842		INTS13	chr12	26905180	26938326	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2137
enhrx-96229	chr2	161491147	161491148	160634636	160634637	5838	hg38	N/A	enh18960	N/A	Enhatls103014	enhancer	E468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088432	0.10842		RBMS1	chr2	160272150	160493807	135016	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8155
enhrx-33958	chr11	121359595	121359596	121488886	121488887	5839	hg38	N/A	N/A	N/A	Enhatls36845	enhancer	E469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26714	0.10843		SORL1	chr11	121452313	121633763	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8627
enhrx-107648	chr21	44764387	44764388	43344507	43344508	5840	hg38	N/A	enh6679	N/A	Enhatls115111	enhancer	E470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15885	0.10843		SIK1	chr21	43414482	43427131	68538	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1531
enhrx-50785	chr14	69183600	69183601	68716883	68716884	5841	hg38	N/A	enh15721	N/A	Enhatls54769	enhancer	E471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18237	0.10843		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2742
enhrx-50598	chr14	66060984	66060985	65594266	65594267	5842	hg38	N/A	enh80861	N/A	Enhatls54576	enhancer	E472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13182	0.10843		FUT8	chr14	65410591	65744121	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2555
enhrx-105145	chr20	49609029	49609030	50992492	50992493	5843	hg38	N/A	enh6535	N/A	Enhatls112448	enhancer	E473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20695	0.10843		KCNG1	chr20	51003655	51023107	2338	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3573
enhrx-101600	chr20	351136	351137	370492	370493	5844	hg38	N/A	enh19428	fant57652	Enhatls108665	enhancer	E474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052824	0.109		TRIB3	chr20	362834	397559	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	28
enhrx-160691	chr8	102773666	102773667	101761438	101761439	5845	hg38	N/A	enh25186	N/A	Enhatls171641	enhancer	E475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061735	0.109		NCALD	chr8	101686541	102124907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4482
enhrx-147281	chr7	1136281	1136282	1096645	1096646	5846	hg38	N/A	enh56136	N/A	Enhatls157409	enhancer	E476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24191	0.10906		C7orf50	chr7	996985	1138260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	93
enhrx-147281	chr7	1136281	1136282	1096645	1096646	5847	hg38	N/A	enh56136	N/A	Enhatls157409	enhancer	E476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24191	0.10906		GPER1	chr7	1082207	1093815	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	93
enhrx-121369	chr3	183684216	183684217	183966428	183966429	5848	hg38	N/A	N/A	N/A	Enhatls129872	enhancer	E477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17735	0.10969		ABCC5	chr3	183919933	184017939	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9498
enhrx-3576	chr1	31808029	31808030	31335182	31335183	5849	hg38	N/A	enh195	N/A	Enhatls3955	enhancer	E478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12789	0.1109		ZCCHC17	chr1	31296981	31364953	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3575
enhrx-40830	chr12	89298689	89298690	88904912	88904913	5850	hg38	N/A	N/A	N/A	Enhatls44123	enhancer	E479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10121	0.11275		KITLG	chr12	88492792	88580851	319228	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6140
enhrx-120976	chr3	176646549	176646550	176928761	176928762	5851	hg38	N/A	enh113424	N/A	Enhatls129448	enhancer	E480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20658	0.11275		TBL1XR1	chr3	177019343	177228000	88857	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9105
enhrx-113075	chr3	24773641	24773642	24732150	24732151	5852	hg38	N/A	N/A	N/A	Enhatls120992	enhancer	E481	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.38587	0.11275		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1204
enhrx-147916	chr7	7456166	7456167	7416535	7416536	5853	hg38	N/A	enh56154	N/A	Enhatls158072	enhancer	E482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037711	0.11275		COL28A1	chr7	7356567	7535873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	728
enhrx-122094	chr3	194826223	194826224	195105494	195105495	5854	hg38	N/A	enh21266	N/A	Enhatls130682	enhancer	E483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19217	0.11275		XXYLT1	chr3	195068283	195271159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10223
enhrx-8959	chr1	111289381	111289382	110746759	110746760	5855	hg38	N/A	enh67100	N/A	Enhatls9662	enhancer	E484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.229	0.11316		KCNA3	chr1	110672464	110674940	69744	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8958
enhrx-105062	chr20	48385084	48385085	49768547	49768548	5856	hg38	N/A	enh19701	fant58975	Enhatls112337	enhancer	E485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19507	0.11371		SLC9A8	chr20	49812712	49892242	44020	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3490
enhrx-94531	chr2	120502083	120502084	119744507	119744508	5857	hg38	N/A	enh33596	N/A	Enhatls101222	enhancer	E486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21163	0.11371		PTPN4	chr2	119759921	119984899	5696	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6457
enhrx-162941	chr9	4507893	4507894	4507893	4507894	5858	hg38	N/A	enh41692	N/A	Enhatls174016	enhancer	E487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30642	0.11371		SLC1A1	chr9	4490467	4587469	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	208
enhrx-34493	chr11	129912093	129912094	130042198	130042199	5859	hg38	N/A	enh14399	fant40469	Enhatls37425	enhancer	E488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15062	0.11374		APLP2	chr11	130068146	130144811	25809	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9162
enhrx-15355	chr1	213001262	213001263	212827920	212827921	5860	hg38	N/A	enh50178	N/A	Enhatls16881	enhancer	E489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24511	0.11374		SPATA45	chr1	212830140	212847649	168	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15354
enhrx-57268	chr15	68208086	68208087	67915748	67915749	5861	hg38	N/A	enh16262	N/A	Enhatls61611	enhancer	E490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093107	0.11377		SKOR1	chr15	67819703	67834582	80660	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3970
enhrx-44243	chr12	133199860	133199861	132623274	132623275	5862	hg38	N/A	N/A	N/A	Enhatls47763	enhancer	E491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1736	0.11377		P2RX2	chr12	132618775	132622388	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9553
enhrx-137395	chr5	168027535	168027536	168600530	168600531	5863	hg38	N/A	enh72112	N/A	Enhatls146826	enhancer	E492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11525	0.11377		PANK3	chr5	168548494	168579368	5933	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7186
enhrx-33902	chr11	120679450	120679451	120808741	120808742	5864	hg38	N/A	enh14332	N/A	Enhatls36787	enhancer	E493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043811	0.11377		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8571
enhrx-20278	chr10	59855422	59855423	58095662	58095663	5865	hg38	N/A	N/A	N/A	Enhatls22340	enhancer	E494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18475	0.1145		IPMK	chr10	58191516	58267894	86101	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2713
enhrx-92106	chr2	74866857	74866858	74639730	74639731	5866	hg38	N/A	N/A	N/A	Enhatls98684	enhancer	E495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24871	0.1145		M1AP	chr2	74557882	74648338	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4032
enhrx-18773	chr10	24759000	24759001	24470071	24470072	5867	hg38	N/A	enh50355	N/A	Enhatls20533	enhancer	E496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11696	0.1145		KIAA1217	chr10	23694745	24547848	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1208
enhrx-116328	chr3	66780328	66780329	66729904	66729905	5868	hg38	N/A	enh97277	N/A	Enhatls124489	enhancer	E497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23339	0.11476		LRIG1	chr3	66378796	66501022	226760	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4457
enhrx-97193	chr2	175893306	175893307	175028578	175028579	5869	hg38	N/A	enh19043	N/A	Enhatls104028	enhancer	E498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0055466	0.11476		CHN1	chr2	174798808	175005381	20700	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9119
enhrx-120147	chr3	153777807	153777808	154060018	154060019	5870	hg38	N/A	enh36006	N/A	Enhatls128548	enhancer	E499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11423	0.1153		ARHGEF26	chr3	154121002	154257827	56188	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8276
enhrx-32477	chr11	101845120	101845121	101974389	101974390	5871	hg38	N/A	enh92326	N/A	Enhatls35262	enhancer	E500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078903	0.11539		CEP126	chr11	101915009	102001062	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7146
enhrx-29169	chr11	60648583	60648584	60881110	60881111	5872	hg38	N/A	enh64474	N/A	Enhatls31689	enhancer	E501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10849	0.11648		ZP1	chr11	60867541	60875687	3286	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3838
enhrx-30779	chr11	68890304	68890305	69122836	69122837	5873	hg38	N/A	enh47499	fant39062	Enhatls33458	enhancer	E502	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20632	0.11648		TPCN2	chr11	69048931	69136316	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5448
enhrx-125910	chr4	77008499	77008500	76087346	76087347	5874	hg38	N/A	enh21587	N/A	Enhatls134704	enhancer	E503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16719	0.11648		ART3	chr4	76011183	76114048	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3454
enhrx-47020	chr13	95053343	95053344	94401089	94401090	5875	hg38	N/A	N/A	N/A	Enhatls50775	enhancer	E504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12547	0.11701		GPC6	chr13	93226806	94408020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2642
enhrx-49440	chr14	47680831	47680832	47211628	47211629	5876	hg38	N/A	N/A	N/A	Enhatls53341	enhancer	E505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24235	0.11702		MDGA2	chr14	46840091	47675605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1397
enhrx-119122	chr3	133147556	133147557	133428712	133428713	5877	hg38	N/A	enh7548	fant13539	Enhatls127475	enhancer	E506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12123	0.11732		BFSP2	chr3	133400055	133475208	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7251
enhrx-70088	chr17	31239595	31239596	32912577	32912578	5878	hg38	N/A	enh17109	N/A	Enhatls75224	enhancer	E507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15186	0.11732		H2BN1	chr17	32895432	32906586	1382	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3357
enhrx-105210	chr20	52296410	52296411	53679871	53679872	5879	hg38	N/A	enh19755	N/A	Enhatls112526	enhancer	E508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2977	0.11737		ZNF217	chr20	53567070	53608892	69475	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3638
enhrx-46592	chr13	72287306	72287307	71713174	71713175	5880	hg38	N/A	enh51580	N/A	Enhatls50308	enhancer	E509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073095	0.11767		DACH1	chr13	71437965	71867204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2214
enhrx-168193	chr9	128495103	128495104	125732824	125732825	5881	hg38	N/A	N/A	N/A	Enhatls180026	enhancer	E510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30721	0.11842		MAPKAP1	chr9	125437392	125707234	4998	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5460
enhrx-137697	chr5	174126414	174126415	174699411	174699412	5882	hg38	N/A	enh97804	N/A	Enhatls147175	enhancer	E511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.224	0.11924		MSX2	chr5	174724581	174730896	23130	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-4261	chr1	37217293	37217294	36751692	36751693	5883	hg38	N/A	enh254	N/A	Enhatls4695	enhancer	E512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024678	0.11924		GRIK3	chr1	36795526	37034515	40233	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4260
enhrx-122265	chr3	196273606	196273607	196546735	196546736	5884	hg38	N/A	enh97427	N/A	Enhatls130870	enhancer	E513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.35621	0.11924		WDR53	chr3	196554176	196568674	5413	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10394
enhrx-42380	chr12	111402763	111402764	110964959	110964960	5885	hg38	N/A	N/A	N/A	Enhatls45782	enhancer	E514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1804	0.11973		MYL2	chr12	110910818	110921443	28929	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7690
enhrx-6579	chr1	65462788	65462789	64997105	64997106	5886	hg38	N/A	enh74247	N/A	Enhatls7169	enhancer	E515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.36303	0.11993		JAK1	chr1	64833228	65067754	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6578
enhrx-102691	chr20	18667568	18667569	18686924	18686925	5887	hg38	N/A	enh19525	N/A	Enhatls109797	enhancer	E516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21689	0.12014		DTD1	chr20	18587963	18766644	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1119
enhrx-43139	chr12	120763425	120763426	120325622	120325623	5888	hg38	N/A	N/A	N/A	Enhatls46580	enhancer	E517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.32089	0.12014		PLA2G1B	chr12	120322114	120327779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8449
enhrx-41515	chr12	102332055	102332056	101938277	101938278	5889	hg38	N/A	enh14928	N/A	Enhatls44860	enhancer	E518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059061	0.12014		DRAM1	chr12	101877579	102012130	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6825
enhrx-140814	chr6	36584949	36584950	36617172	36617173	5890	hg38	N/A	enh23193	N/A	Enhatls150531	enhancer	E519	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22297	0.12078		SRSF3	chr6	36594361	36605600	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2402
enhrx-138927	chr6	12602754	12602755	12602522	12602523	5891	hg38	N/A	enh8957	fant21596	Enhatls148526	enhancer	E520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25585	0.12143		PHACTR1	chr6	12716553	13290446	113655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	515
enhrx-51412	chr14	76178172	76178173	75711829	75711830	5892	hg38	N/A	enh64804	N/A	Enhatls55445	enhancer	E521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24143	0.12164		TTLL5	chr14	75661223	75955079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3369
enhrx-41818	chr12	106589691	106589692	106195913	106195914	5893	hg38	N/A	enh43811	N/A	Enhatls45190	enhancer	E522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083782	0.12225		CKAP4	chr12	106237880	106304279	38190	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-68583	chr17	14352259	14352260	14448942	14448943	5894	hg38	N/A	N/A	N/A	Enhatls73599	enhancer	E523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092506	0.12244		HS3ST3B1	chr17	14301080	14349404	91143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1852
enhrx-94919	chr2	129922684	129922685	129165111	129165112	5895	hg38	N/A	N/A	N/A	Enhatls101631	enhancer	E524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061132	0.12245		RAB6C	chr2	129979665	129982738	803272	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6845
enhrx-112431	chr3	11227491	11227492	11185805	11185806	5896	hg38	N/A	enh20322	N/A	Enhatls120304	enhancer	E525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18327	0.12254		HRH1	chr3	11137092	11263557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	560
enhrx-167901	chr9	124934071	124934072	122171792	122171793	5897	hg38	N/A	N/A	N/A	Enhatls179715	enhancer	E526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24727	0.12331		MORN5	chr9	122159907	122200088	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5168
enhrx-123451	chr4	12863185	12863186	12861561	12861562	5898	hg38	N/A	N/A	N/A	Enhatls132120	enhancer	E527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2243	0.12346		RAB28	chr4	13361353	13484365	487653	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	995
enhrx-49983	chr14	57536609	57536610	57069891	57069892	5899	hg38	N/A	enh47764	N/A	Enhatls53938	enhancer	E528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21836	0.12347		EXOC5	chr14	57200506	57268905	126670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1940
enhrx-65864	chr16	80648022	80648023	80614125	80614126	5900	hg38	N/A	enh16822	N/A	Enhatls70688	enhancer	E529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17322	0.12413		CDYL2	chr16	80597906	80804598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6159
enhrx-96067	chr2	159981090	159981091	159124578	159124579	5901	hg38	N/A	enh18933	N/A	Enhatls102839	enhancer	E530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21383	0.12532		TANC1	chr2	158968639	159232659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7993
enhrx-97566	chr2	181580047	181580048	180715320	180715321	5902	hg38	N/A	N/A	N/A	Enhatls104408	enhancer	E531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060028	0.1255		UBE2E3	chr2	180967247	181063441	248350	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9492
enhrx-58803	chr15	86369146	86369147	85825915	85825916	5903	hg38	N/A	enh52137	N/A	Enhatls63327	enhancer	E532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01084	0.1255		KLHL25	chr15	85759325	85794925	28250	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-77708	chr18	40614801	40614802	43034836	43034837	5904	hg38	N/A	N/A	N/A	Enhatls83376	enhancer	E533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27615	0.1255		RIT2	chr18	42743226	43115691	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1726
enhrx-23105	chr10	102643354	102643355	100883597	100883598	5905	hg38	N/A	enh1467	N/A	Enhatls25366	enhancer	E534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20163	0.12559		SLF2	chr10	100912962	100965134	12725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5540
enhrx-21638	chr10	82762370	82762371	81002614	81002615	5906	hg38	N/A	N/A	N/A	Enhatls23820	enhancer	E535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07768	0.12559		SH2D4B	chr10	80537901	80646560	336780	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-157844	chr8	29083372	29083373	29225855	29225856	5907	hg38	N/A	enh46550	fant29134	Enhatls168622	enhancer	E536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0054632	0.12649		KIF13B	chr8	29067277	29263097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1635
enhrx-119301	chr3	136062499	136062500	136343657	136343658	5908	hg38	N/A	N/A	N/A	Enhatls127659	enhancer	E537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13237	0.12649		STAG1	chr3	136336235	136752403	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7430
enhrx-4406	chr1	38761494	38761495	38295822	38295823	5909	hg38	N/A	N/A	N/A	Enhatls4851	enhancer	E538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044755	0.12657		POU3F1	chr1	38043828	38046793	247611	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4405
enhrx-172181	chrX	44826663	44826664	44967418	44967419	5910	hg38	N/A	enh85668	N/A	Enhatls184224	enhancer	E539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18282	0.12726		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1898
enhrx-14488	chr1	203285820	203285821	203316692	203316693	5911	hg38	N/A	enh883	N/A	Enhatls15944	enhancer	E540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27091	0.12726		BTG2	chr1	203305518	203309602	721	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14487
enhrx-52417	chr14	95806728	95806729	95340391	95340392	5912	hg38	N/A	enh51926	N/A	Enhatls56527	enhancer	E541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09345	0.12736		CLMN	chr14	95181939	95319908	17381	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4374
enhrx-75970	chr17	81122360	81122361	83174591	83174592	5913	hg38	N/A	enh4651	N/A	Enhatls81526	enhancer	E542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12098	0.12736		METRNL	chr17	83079608	83095122	77375	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9239
enhrx-48900	chr14	31551382	31551383	31082176	31082177	5914	hg38	N/A	N/A	N/A	Enhatls52792	enhancer	E543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071416	0.12788		AP4S1	chr14	31025105	31130996	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	857
enhrx-24774	chr10	127313584	127313585	125625015	125625016	5915	hg38	N/A	enh74696	N/A	Enhatls27127	enhancer	E544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095572	0.12788		TEX36	chr10	125576521	125683163	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7209
enhrx-132397	chr5	60704537	60704538	61408710	61408711	5916	hg38	hs3003	enh22276	N/A	Enhatls141491	enhancer	E545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26266	0.12844		ZSWIM6	chr5	61332257	61546172	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2188
enhrx-11046	chr1	155946622	155946623	155976831	155976832	5917	hg38	N/A	enh12293	fant3240	Enhatls12288	enhancer	E546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21367	0.12844		ARHGEF2	chr1	155946850	156007070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11045
enhrx-168052	chr9	127029702	127029703	124267423	124267424	5918	hg38	N/A	enh10984	fant33643	Enhatls179866	enhancer	E547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18758	0.12844		NEK6	chr9	124257605	124353307	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5319
enhrx-82506	chr19	17241884	17241885	17131074	17131075	5919	hg38	N/A	enh5038	N/A	Enhatls88474	enhancer	E548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22861	0.12919		MYO9B	chr19	17075776	17214537	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3476
enhrx-3556	chr1	31643722	31643723	31170875	31170876	5920	hg38	N/A	enh11711	N/A	Enhatls3936	enhancer	E549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16386	0.12936		NKAIN1	chr1	31179744	31239887	8769	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3555
enhrx-162722	chr8	146120956	146120957	144895571	144895572	5921	hg38	N/A	N/A	N/A	Enhatls173783	enhancer	E550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22754	0.12975		ZNF250	chr8	144876950	144902168	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6513
enhrx-43575	chr12	123373208	123373209	122888661	122888662	5922	hg38	N/A	enh15073	N/A	Enhatls47040	enhancer	E551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3276	0.12975		VPS37B	chr12	122865329	122896127	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8885
enhrx-134433	chr5	108804603	108804604	109468902	109468903	5923	hg38	N/A	N/A	fant19484	Enhatls143601	enhancer	E552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29802	0.13045		PJA2	chr5	109334712	109409974	58888	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4224
enhrx-146132	chr6	151979946	151979947	151658811	151658812	5924	hg38	N/A	N/A	N/A	Enhatls156204	enhancer	E553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24911	0.13076		ESR1	chr6	151690495	152129619	29866	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-121602	chr3	184849852	184849853	185132064	185132065	5925	hg38	N/A	N/A	N/A	Enhatls130116	enhancer	E554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20958	0.13076		C3orf70	chr3	185076837	185153060	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9731
enhrx-157027	chr8	18354592	18354593	18497082	18497083	5926	hg38	N/A	enh109159	N/A	Enhatls167749	enhancer	E555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10752	0.13126		PSD3	chr8	18527302	19084730	29278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	818
enhrx-137002	chr5	154505072	154505073	155125512	155125513	5927	hg38	N/A	enh97782	N/A	Enhatls146396	enhancer	E556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19929	0.13227		KIF4B	chr5	155013754	155018141	105245	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6793
enhrx-113297	chr3	32338440	32338441	32296948	32296949	5928	hg38	N/A	enh20479	N/A	Enhatls121227	enhancer	E557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14346	0.1324		CMTM8	chr3	32238678	32370321	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1426
enhrx-138476	chr6	1641696	1641697	1641462	1641463	5929	hg38	N/A	enh8915	fant21178	Enhatls148035	enhancer	E558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17362	0.13385		GMDS	chr6	1623805	2245605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	64
enhrx-141201	chr6	41499774	41499775	41532036	41532037	5930	hg38	N/A	enh38996	N/A	Enhatls150953	enhancer	E559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063667	0.13385		FOXP4	chr6	41546380	41602384	7632	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-119983	chr3	149435249	149435250	149717462	149717463	5931	hg38	N/A	N/A	N/A	Enhatls128366	enhancer	E560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21428	0.13473		COMMD2	chr3	149738471	149752489	44	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8112
enhrx-38493	chr12	52629986	52629987	52236202	52236203	5932	hg38	N/A	enh80195	fant41771	Enhatls41662	enhancer	E561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18834	0.13473		KRT7	chr12	52233242	52248921	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3803
enhrx-161913	chr8	134633308	134633309	133621065	133621066	5933	hg38	N/A	enh10578	N/A	Enhatls172951	enhancer	E562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26815	0.13533		ST3GAL1	chr8	133454847	133571925	41272	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5704
enhrx-36748	chr12	25557977	25557978	25405043	25405044	5934	hg38	N/A	N/A	N/A	Enhatls39832	enhancer	E563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030198	0.13533		LMNTD1	chr12	25409306	25648579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2058
enhrx-81109	chr19	9982551	9982552	9871875	9871876	5935	hg38	N/A	enh32884	N/A	Enhatls86979	enhancer	E564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21857	0.13536		OLFM2	chr19	9853717	9936515	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2079
enhrx-154969	chr7	141161258	141161259	141461458	141461459	5936	hg38	N/A	enh63725	N/A	Enhatls165597	enhancer	E565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23024	0.13537		TMEM178B	chr7	141074063	141480380	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7781
enhrx-137666	chr5	172729978	172729979	173302975	173302976	5937	hg38	N/A	enh22820	N/A	Enhatls147133	enhancer	E566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25196	0.13582		STC2	chr5	173314722	173328414	10762	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7457
enhrx-169615	chr9	138285613	138285614	135393767	135393768	5938	hg38	N/A	enh98304	fant34146	Enhatls181535	enhancer	E567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31926	0.13586		PPP1R26	chr9	135479078	135488893	85037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6882
enhrx-120785	chr3	170210862	170210863	170493073	170493074	5939	hg38	N/A	enh70958	N/A	Enhatls129240	enhancer	E568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099485	0.13597		SLC7A14	chr3	170459547	170586075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8914
enhrx-31768	chr11	82804044	82804045	83093002	83093003	5940	hg38	N/A	enh14153	N/A	Enhatls34521	enhancer	E569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25479	0.13674		RAB30	chr11	82973132	83071923	18231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6437
enhrx-111081	chr22	43201294	43201295	42805288	42805289	5941	hg38	N/A	enh45302	N/A	Enhatls118864	enhancer	E570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29157	0.13704		ARFGAP3	chr22	42796501	42858106	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2912
enhrx-161142	chr8	116668137	116668138	115655910	115655911	5942	hg38	N/A	N/A	N/A	Enhatls172100	enhancer	E571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25128	0.13704		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4933
enhrx-42835	chr12	116941182	116941183	116503377	116503378	5943	hg38	N/A	enh43835	N/A	Enhatls46256	enhancer	E572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0096654	0.13704		MAP1LC3B2	chr12	116559380	116576606	50512	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-146144	chr6	152446015	152446016	152124880	152124881	5944	hg38	N/A	N/A	N/A	Enhatls156216	enhancer	E573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15816	0.13711		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7732
enhrx-146144	chr6	152446015	152446016	152124880	152124881	5945	hg38	N/A	N/A	N/A	Enhatls156216	enhancer	E573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15816	0.13711		SYNE1	chr6	152121686	152637801	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7732
enhrx-41657	chr12	104303738	104303739	103909960	103909961	5946	hg38	N/A	enh43801	N/A	Enhatls45019	enhancer	E574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31942	0.13711		HSP90B1	chr12	103930106	103953931	18795	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6967
enhrx-91077	chr2	58759921	58759922	58532786	58532787	5947	hg38	N/A	enh69714	N/A	Enhatls97586	enhancer	E575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13668	0.13778		FANCL	chr2	58159242	58241410	289297	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3003
enhrx-114090	chr3	44182224	44182225	44140732	44140733	5948	hg38	N/A	N/A	N/A	Enhatls122092	enhancer	E576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13902	0.13809		TOPAZ1	chr3	44241885	44332098	83013	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2219
enhrx-52432	chr14	95954843	95954844	95488506	95488507	5949	hg38	N/A	enh3416	N/A	Enhatls56543	enhancer	E577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095161	0.13829		SYNE3	chr14	95407265	95516650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4389
enhrx-14185	chr1	201278702	201278703	201309574	201309575	5950	hg38	N/A	enh12518	fant4281	Enhatls15615	enhancer	E578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29674	0.13829		PKP1	chr1	201283451	201332993	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14184
enhrx-96382	chr2	165379261	165379262	164522751	164522752	5951	hg38	N/A	N/A	N/A	Enhatls103173	enhancer	E579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030997	0.13829		GRB14	chr2	164492416	164621482	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8308
enhrx-2839	chr1	24543111	24543112	24216621	24216622	5952	hg38	N/A	enh95839	N/A	Enhatls3169	enhancer	E580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093741	0.13882		GRHL3	chr1	24199557	24364482	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2838
enhrx-26658	chr11	11627758	11627759	11606211	11606212	5953	hg38	N/A	enh13772	N/A	Enhatls29067	enhancer	E581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22063	0.13968		GALNT18	chr11	11270876	11622005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1327
enhrx-148622	chr7	25660220	25660221	25620600	25620601	5954	hg38	N/A	enh24039	N/A	Enhatls158827	enhancer	E582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018169	0.13968		NPVF	chr7	25224569	25228486	392055	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1434
enhrx-64525	chr16	65514147	65514148	65480244	65480245	5955	hg38	N/A	enh81131	N/A	Enhatls69257	enhancer	E583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19813	0.14018		CDH11	chr16	64943752	65122365	355758	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4820
enhrx-18248	chr10	13889888	13889889	13847888	13847889	5956	hg38	N/A	enh27823	N/A	Enhatls19937	enhancer	E584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14604	0.14018		FRMD4A	chr10	13643705	14462142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	683
enhrx-122198	chr3	195774294	195774295	196047423	196047424	5957	hg38	N/A	N/A	N/A	Enhatls130798	enhancer	E585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21189	0.14032		TFRC	chr3	196049283	196082094	5	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10327
enhrx-173101	chrX	54667484	54667485	54641051	54641052	5958	hg38	N/A	enh11213	N/A	Enhatls185296	enhancer	E586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19985	0.14049		GNL3L	chrX	54530182	54621521	18457	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2818
enhrx-136167	chr5	141601046	141601047	142221481	142221482	5959	hg38	N/A	enh38456	N/A	Enhatls145467	enhancer	E587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20027	0.14049		NDFIP1	chr5	142108778	142154440	57961	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5958
enhrx-113611	chr3	37928816	37928817	37887325	37887326	5960	hg38	N/A	N/A	N/A	Enhatls121565	enhancer	E588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25551	0.14092		CTDSPL	chr3	37861879	37984469	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1740
enhrx-22339	chr10	95535242	95535243	93775485	93775486	5961	hg38	N/A	N/A	N/A	Enhatls24568	enhancer	E589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30179	0.142		LGI1	chr10	93757850	93806134	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4774
enhrx-104870	chr20	46084126	46084127	47455382	47455383	5962	hg38	N/A	enh19677	N/A	Enhatls112130	enhancer	E591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0572	0.14236		NCOA3	chr20	47501886	47656877	42013	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3298
enhrx-130711	chr5	10458147	10458148	10458035	10458036	5963	hg38	N/A	enh37595	N/A	Enhatls139722	enhancer	E592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090144	0.14261		ROPN1L	chr5	10441523	10465026	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	502
enhrx-32481	chr11	101885533	101885534	102014802	102014803	5964	hg38	N/A	enh14230	N/A	Enhatls35267	enhancer	E593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22329	0.14261		CEP126	chr11	101915009	102001062	10310	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7150
enhrx-161706	chr8	131277062	131277063	130264816	130264817	5965	hg38	N/A	enh10561	N/A	Enhatls172735	enhancer	E594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28339	0.14261		ASAP1	chr8	130052103	130443674	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5497
enhrx-147357	chr7	1556430	1556431	1516794	1516795	5966	hg38	N/A	enh23920	N/A	Enhatls157481	enhancer	E595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16464	0.14261		MAFK	chr7	1530701	1543043	5283	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	169
enhrx-105154	chr20	50103157	50103158	51486620	51486621	5967	hg38	N/A	enh6540	N/A	Enhatls112459	enhancer	E596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.088517	0.14279		NFATC2	chr20	51386956	51562831	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3582
enhrx-130826	chr5	14009303	14009304	14009194	14009195	5968	hg38	N/A	enh63387	N/A	Enhatls139841	enhancer	E597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13707	0.14377		DNAH5	chr5	13690327	14011818	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	617
enhrx-170905	chrX	13740205	13740206	13722086	13722087	5969	hg38	N/A	N/A	N/A	Enhatls182887	enhancer	E598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027749	0.14377		TRAPPC2	chrX	13712243	13734635	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	622
enhrx-1610	chr1	14786242	14786243	14459746	14459747	5970	hg38	N/A	N/A	N/A	Enhatls1786	enhancer	E599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17517	0.14401		KAZN	chr1	13892791	15118043	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1609
enhrx-35020	chr12	3623704	3623705	3514538	3514539	5971	hg38	N/A	N/A	N/A	Enhatls38008	enhancer	E600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16636	0.14435		PRMT8	chr12	3381348	3593973	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	330
enhrx-70243	chr17	33916696	33916697	35589677	35589678	5972	hg38	N/A	N/A	N/A	Enhatls75374	enhancer	E601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22052	0.14455		AP2B1	chr17	35578045	35726413	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3512
enhrx-17683	chr10	3028651	3028652	2986459	2986460	5973	hg38	N/A	enh27727	N/A	Enhatls19320	enhancer	E602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20192	0.14463		PFKP	chr10	3066332	3137718	78290	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	118
enhrx-109970	chr22	32953578	32953579	32557592	32557593	5974	hg38	N/A	enh20148	N/A	Enhatls117675	enhancer	E603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17862	0.14475		SYN3	chr22	32507819	33058381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1801
enhrx-17723	chr10	3895999	3896000	3853807	3853808	5975	hg38	N/A	enh12923	N/A	Enhatls19362	enhancer	E604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2452	0.14482		KLF6	chr10	3775995	3785281	67540	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	158
enhrx-18149	chr10	12915358	12915359	12873358	12873359	5976	hg38	N/A	enh96028	N/A	Enhatls19837	enhancer	E605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12516	0.14482		CCDC3	chr10	12896624	13099652	19210	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	584
enhrx-57390	chr15	70289399	70289400	69997060	69997061	5977	hg38	N/A	enh3695	N/A	Enhatls61752	enhancer	E606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14426	0.14482		TLE3	chr15	70047789	70098176	50613	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4092
enhrx-21514	chr10	80888498	80888499	79128741	79128742	5978	hg38	N/A	enh1379	N/A	Enhatls23677	enhancer	E607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06745	0.14522		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-3713	chr1	32308628	32308629	31843027	31843028	5979	hg38	N/A	enh58086	N/A	Enhatls4115	enhancer	E608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12992	0.14522		SPOCD1	chr1	31790421	31816022	24903	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3712
enhrx-37733	chr12	47791577	47791578	47397794	47397795	5980	hg38	N/A	enh2319	N/A	Enhatls40864	enhancer	E609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30376	0.14594		PCED1B	chr12	47079602	47236662	158227	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3043
enhrx-121843	chr3	189034314	189034315	189316525	189316526	5981	hg38	N/A	enh82907	N/A	Enhatls130396	enhancer	E610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28989	0.14594		TPRG1	chr3	188947213	189325304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9972
enhrx-140544	chr6	34566607	34566608	34598830	34598831	5982	hg38	N/A	enh55720	N/A	Enhatls150249	enhancer	E611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14299	0.14633		ILRUN	chr6	34587287	34696859	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2132
enhrx-14898	chr1	206862491	206862492	206689146	206689147	5983	hg38	N/A	enh27440	N/A	Enhatls16402	enhancer	E612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27342	0.14634		MAPKAPK2	chr1	206684904	206734281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14897
enhrx-17097	chr1	240639397	240639398	240476097	240476098	5984	hg38	N/A	N/A	N/A	Enhatls18709	enhancer	E613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01245	0.14658		GREM2	chr1	240489572	240612155	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17096
enhrx-138791	chr6	8463188	8463189	8462955	8462956	5985	hg38	N/A	N/A	N/A	Enhatls148377	enhancer	E614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22458	0.14658		SLC35B3	chr6	8411434	8435545	5167	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	379
enhrx-22104	chr10	93350433	93350434	91590676	91590677	5986	hg38	hs1950	enh13399	N/A	Enhatls24313	enhancer	E615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16294	0.14673		PPP1R3C	chr10	91628441	91633071	36479	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4539
enhrx-113299	chr3	32463906	32463907	32422414	32422415	5987	hg38	N/A	enh7086	N/A	Enhatls121231	enhancer	E616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28838	0.14673		CMTM7	chr3	32391697	32455528	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1428
enhrx-168214	chr9	129405371	129405372	126643092	126643093	5988	hg38	N/A	enh89353	N/A	Enhatls180049	enhancer	E617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15253	0.14708		LMX1B	chr9	126613927	126701032	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5481
enhrx-50782	chr14	68749121	68749122	68282404	68282405	5989	hg38	N/A	enh3299	N/A	Enhatls54763	enhancer	E618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21155	0.14708		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-39627	chr12	58312095	58312096	57918312	57918313	5990	hg38	N/A	enh47587	N/A	Enhatls42836	enhancer	E619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12386	0.14708		ATP23	chr12	57941566	57959148	21235	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-167694	chr9	122636351	122636352	119874073	119874074	5991	hg38	N/A	N/A	N/A	Enhatls179480	enhancer	E620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10803	0.14708		BRINP1	chr9	119166628	119369435	499190	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4961
enhrx-63903	chr16	54128786	54128787	54094874	54094875	5992	hg38	N/A	enh96685	N/A	Enhatls68586	enhancer	E621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067515	0.14708		FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4198
enhrx-102600	chr20	17909400	17909401	17928756	17928757	5993	hg38	N/A	enh19518	N/A	Enhatls109704	enhancer	E622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050756	0.14752		SNX5	chr20	17941596	17968980	9966	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1028
enhrx-15200	chr1	210547378	210547379	210374034	210374035	5994	hg38	N/A	enh27456	N/A	Enhatls16722	enhancer	E623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11338	0.14833		HHAT	chr1	210328251	210676296	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15199
enhrx-112564	chr3	13319623	13319624	13278123	13278124	5995	hg38	N/A	enh20348	N/A	Enhatls120450	enhancer	E624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098403	0.14856		IQSEC1	chr3	12897042	13283281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	693
enhrx-172180	chrX	44733776	44733777	44874530	44874531	5996	hg38	N/A	N/A	N/A	Enhatls184223	enhancer	E625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11472	0.14856		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1897
enhrx-161483	chr8	124970074	124970075	123957834	123957835	5997	hg38	N/A	enh110455	N/A	Enhatls172474	enhancer	E626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10549	0.14856		FER1L6	chr8	123851986	124120061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5274
enhrx-119488	chr3	139032996	139032997	139314154	139314155	5998	hg38	N/A	enh20980	N/A	Enhatls127858	enhancer	E627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21579	0.14856		MRPS22	chr3	139005805	139360497	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7617
enhrx-140539	chr6	34506507	34506508	34538730	34538731	5999	hg38	N/A	N/A	N/A	Enhatls150243	enhancer	E628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071352	0.14856		SPDEF	chr6	34537801	34556333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2127
enhrx-31246	chr11	73780316	73780317	74069271	74069272	6000	hg38	N/A	N/A	N/A	Enhatls33958	enhancer	E629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21598	0.14874		C2CD3	chr11	74012717	74171210	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5915
enhrx-152312	chr7	99620535	99620536	100022912	100022913	6001	hg38	N/A	N/A	N/A	Enhatls162783	enhancer	E630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031412	0.14874		ZKSCAN1	chr7	100015571	100041689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5124
enhrx-72414	chr17	47472419	47472420	49395057	49395058	6002	hg38	N/A	enh4461	N/A	Enhatls77729	enhancer	E631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11088	0.14943		PHB1	chr17	49404048	49414905	6796	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5683
enhrx-66323	chr16	87846139	87846140	87812533	87812534	6003	hg38	N/A	enh4180	N/A	Enhatls71216	enhancer	E632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033465	0.14943		SLC7A5	chr16	87830022	87869507	16574	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6618
enhrx-47827	chr13	113560407	113560408	112906093	112906094	6004	hg38	N/A	enh68643	N/A	Enhatls51652	enhancer	E633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091813	0.15065		MCF2L	chr13	112894377	113099742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3449
enhrx-22227	chr10	94652330	94652331	92892573	92892574	6005	hg38	N/A	N/A	N/A	Enhatls24440	enhancer	E634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090462	0.15111		EXOC6	chr10	92826830	93059493	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4662
enhrx-127353	chr4	107339405	107339406	106418248	106418249	6006	hg38	N/A	N/A	N/A	Enhatls136206	enhancer	E635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042286	0.15157		GIMD1	chr4	106357391	106368778	47801	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4897
enhrx-74228	chr17	70498146	70498147	72502006	72502007	6007	hg38	N/A	enh17356	fant53626	Enhatls79688	enhancer	E636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067191	0.15184		SLC39A11	chr17	72645948	73092712	143644	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-75216	chr17	76948328	76948329	78952246	78952247	6008	hg38	N/A	enh17420	N/A	Enhatls80749	enhancer	E637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12016	0.15184		LGALS3BP	chr17	78971237	78979935	17175	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8485
enhrx-122933	chr4	3113398	3113399	3111671	3111672	6009	hg38	N/A	enh21315	N/A	Enhatls131548	enhancer	E638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070991	0.1531		HTT	chr4	3041362	3243957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	477
enhrx-144414	chr6	113754763	113754764	113433561	113433562	6010	hg38	N/A	enh23531	N/A	Enhatls154343	enhancer	E639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097619	0.15311		MARCKS	chr6	113857344	113863475	420812	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-147248	chr7	921295	921296	881658	881659	6011	hg38	N/A	enh46297	N/A	Enhatls157370	enhancer	E640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.006708	0.15311		GET4	chr7	876553	896436	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	60
enhrx-150699	chr7	74024815	74024816	74610492	74610493	6012	hg38	N/A	enh9864	N/A	Enhatls161083	enhancer	E641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08287	0.15311		GTF2IRD1	chr7	74453789	74602605	4219	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3511
enhrx-15873	chr1	224074475	224074476	223886773	223886774	6013	hg38	N/A	enh27572	N/A	Enhatls17427	enhancer	E642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036536	0.15311		TP53BP2	chr1	223779892	223845947	38574	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15872
enhrx-50915	chr14	71132299	71132300	70665582	70665583	6014	hg38	N/A	enh3310	fant46556	Enhatls54908	enhancer	E643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17033	0.15311		TTC9	chr14	70641915	70675366	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2872
enhrx-158054	chr8	37454714	37454715	37597196	37597197	6015	hg38	N/A	enh24921	N/A	Enhatls168869	enhancer	E644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17597	0.15311		ZNF703	chr8	37695781	37700019	80905	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1845
enhrx-132344	chr5	59637289	59637290	60341462	60341463	6016	hg38	N/A	N/A	N/A	Enhatls141440	enhancer	E645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19992	0.15433		PDE4D	chr5	58969037	60488076	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-42208	chr12	110302953	110302954	109865148	109865149	6017	hg38	N/A	enh14985	N/A	Enhatls45597	enhancer	E646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18229	0.15519		GLTP	chr12	109850944	109880541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7518
enhrx-41818	chr12	106629696	106629697	106235918	106235919	6018	hg38	N/A	enh29960	N/A	Enhatls45190	enhancer	E647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14694	0.15519		CKAP4	chr12	106237880	106304279	1104	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-71208	chr17	39822210	39822211	41665958	41665959	6019	hg38	N/A	enh4409	fant52687	Enhatls76405	enhancer	E648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23501	0.15519		EIF1	chr17	41688884	41692668	22193	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4477
enhrx-66210	chr16	85355755	85355756	85322149	85322150	6020	hg38	N/A	enh16866	fant51256	Enhatls71076	enhancer	E649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24254	0.15519		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-25119	chr10	134221552	134221553	132408048	132408049	6021	hg38	N/A	enh1589	fant37519	Enhatls27457	enhancer	E650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28353	0.15519		PWWP2B	chr10	132397167	132417859	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7554
enhrx-100927	chr2	236507649	236507650	235599005	235599006	6022	hg38	N/A	enh19367	N/A	Enhatls107964	enhancer	E651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18029	0.15552		AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12853
enhrx-132667	chr5	66511099	66511100	67215271	67215272	6023	hg38	N/A	enh8491	fant18776	Enhatls141777	enhancer	E652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04971	0.15616		CD180	chr5	67179612	67196799	18129	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2458
enhrx-75319	chr17	78042346	78042347	80068547	80068548	6024	hg38	hs2709	enh44507	N/A	Enhatls80846	enhancer	E653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24079	0.15746		CCDC40	chr17	80036631	80100613	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8588
enhrx-175116	chrX	102954376	102954377	103699448	103699449	6025	hg38	N/A	enh98355	N/A	Enhatls187294	enhancer	E654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090112	0.15746		MORF4L2	chrX	103675495	103688158	9200	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4833
enhrx-48776	chr14	25423651	25423652	24954445	24954446	6026	hg38	N/A	enh15546	N/A	Enhatls52658	enhancer	E655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052411	0.15746		STXBP6	chr14	24809453	25050147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	733
enhrx-76712	chr18	13267511	13267512	13267512	13267513	6027	hg38	N/A	enh17580	N/A	Enhatls82317	enhancer	E656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10482	0.15746		LDLRAD4	chr18	13217685	13652755	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	730
enhrx-120831	chr3	170979400	170979401	171261611	171261612	6028	hg38	N/A	enh36113	N/A	Enhatls129293	enhancer	E657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20242	0.15746		TNIK	chr3	171058413	171460408	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8960
enhrx-16502	chr1	231173954	231173955	231038208	231038209	6029	hg38	N/A	N/A	N/A	Enhatls18093	enhancer	E658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084096	0.15746		FAM89A	chr1	231018957	231040254	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16501
enhrx-14029	chr1	200265601	200265602	200296473	200296474	6030	hg38	N/A	enh867	N/A	Enhatls15457	enhancer	E659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093234	0.15772		ZNF281	chr1	200404939	200410056	94889	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14028
enhrx-137324	chr5	164065328	164065329	164638322	164638323	6031	hg38	N/A	N/A	N/A	Enhatls146750	enhancer	E660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0095063	0.15772		MAT2B	chr5	163503113	163519558	1083052	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7115
enhrx-105548	chr20	60449854	60449855	61874798	61874799	6032	hg38	N/A	N/A	N/A	Enhatls112893	enhancer	E661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30434	0.15774		CDH4	chr20	61252260	61940617	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3976
enhrx-148093	chr7	13781907	13781908	13742282	13742283	6033	hg38	N/A	enh39887	N/A	Enhatls158261	enhancer	E662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24273	0.15854		ETV1	chr7	13891228	13991425	146180	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	905
enhrx-140807	chr6	36525724	36525725	36557947	36557948	6034	hg38	N/A	enh61383	N/A	Enhatls150524	enhancer	E663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18678	0.15876		STK38	chr6	36493891	36547479	8370	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2395
enhrx-10216	chr1	150934475	150934476	150961999	150962000	6035	hg38	N/A	N/A	N/A	Enhatls11419	enhancer	E664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27841	0.15929		SETDB1	chr1	150926262	150964744	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10215
enhrx-111040	chr22	42858030	42858031	42462024	42462025	6036	hg38	N/A	enh53955	N/A	Enhatls118817	enhancer	E665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12193	0.15974		NFAM1	chr22	42380406	42432403	25437	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2871
enhrx-74357	chr17	72391420	72391421	74395281	74395282	6037	hg38	N/A	enh48064	fant53707	Enhatls79832	enhancer	E666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098066	0.15974		GPR142	chr17	74367457	74372600	22392	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7626
enhrx-167210	chr9	114244566	114244567	111482286	111482287	6038	hg38	N/A	N/A	N/A	Enhatls178956	enhancer	E667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13119	0.15974		ECPAS	chr9	111360684	111484745	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4477
enhrx-110602	chr22	39680462	39680463	39284457	39284458	6039	hg38	N/A	enh6860	N/A	Enhatls118367	enhancer	E668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.088767	0.15999		RPL3	chr22	39312881	39319623	25777	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2433
enhrx-46969	chr13	90857620	90857621	90205366	90205367	6040	hg38	N/A	N/A	N/A	Enhatls50719	enhancer	E669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25195	0.16025		GPC5	chr13	91398620	92873682	1172611	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2591
enhrx-30037	chr11	65246897	65246898	65479426	65479427	6041	hg38	N/A	enh1826	fant38915	Enhatls32635	enhancer	E670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10522	0.16051		SCYL1	chr11	65525076	65538704	45270	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4706
enhrx-24903	chr10	129157048	129157049	127358784	127358785	6042	hg38	N/A	N/A	N/A	Enhatls27263	enhancer	E671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16623	0.16051		DOCK1	chr10	126905408	127452517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7338
enhrx-75857	chr17	80355044	80355045	82397168	82397169	6043	hg38	N/A	N/A	N/A	Enhatls81401	enhancer	E672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051711	0.16109		OGFOD3	chr17	82389209	82418588	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9126
enhrx-119983	chr3	149454126	149454127	149736339	149736340	6044	hg38	N/A	N/A	N/A	Enhatls128366	enhancer	E673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.3122	0.16109		COMMD2	chr3	149738471	149752489	44	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8112
enhrx-75503	chr17	78992097	78992098	81018297	81018298	6045	hg38	N/A	enh17432	N/A	Enhatls81033	enhancer	E674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20905	0.16109		CHMP6	chr17	80991597	81009517	6609	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8772
enhrx-105367	chr20	56630081	56630082	58055025	58055026	6046	hg38	N/A	enh65489	N/A	Enhatls112687	enhancer	E675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13463	0.16109		CIMIP1	chr20	58150901	58161150	93483	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3795
enhrx-137636	chr5	172264768	172264769	172837765	172837766	6047	hg38	N/A	enh22817	fant20865	Enhatls147099	enhancer	E676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047327	0.16109		ERGIC1	chr5	172834250	172952683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7427
enhrx-58981	chr15	89923223	89923224	89379992	89379993	6048	hg38	N/A	enh3783	N/A	Enhatls63513	enhancer	E677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0025427	0.16109		POLG	chr15	89305197	89334861	45103	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5683
enhrx-72571	chr17	48385176	48385177	50307815	50307816	6049	hg38	N/A	enh44449	N/A	Enhatls77911	enhancer	E678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15313	0.16109		TMEM92	chr17	50271405	50281485	13866	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5840
enhrx-122026	chr3	193430127	193430128	193712338	193712339	6050	hg38	N/A	enh71060	N/A	Enhatls130592	enhancer	E679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.34602	0.16109		OPA1	chr3	193593143	193697811	10755	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10155
enhrx-94583	chr2	121322343	121322344	120564767	120564768	6051	hg38	N/A	enh33602	N/A	Enhatls101279	enhancer	E680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094889	0.16109		GLI2	chr2	120735622	120992653	162084	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-23060	chr10	102202501	102202502	100442744	100442745	6052	hg38	N/A	N/A	N/A	Enhatls25320	enhancer	E681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14846	0.16162		WNT8B	chr10	100463008	100483744	18721	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5495
enhrx-169079	chr9	134258781	134258782	131383394	131383395	6053	hg38	N/A	enh26082	fant33929	Enhatls180991	enhancer	E682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010459	0.16184		PRRC2B	chr9	131373635	131500197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6346
enhrx-105119	chr20	49287222	49287223	50670685	50670686	6054	hg38	N/A	enh19726	N/A	Enhatls112425	enhancer	E683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2039	0.16199		RIPOR3	chr20	50586107	50691542	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3547
enhrx-148815	chr7	30590823	30590824	30551207	30551208	6055	hg38	N/A	N/A	N/A	Enhatls159046	enhancer	E684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090509	0.16199		GARS1	chr7	30580532	30634033	28439	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1627
enhrx-65868	chr16	81002844	81002845	80968947	80968948	6056	hg38	N/A	N/A	N/A	Enhatls70692	enhancer	E685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27604	0.16199		CMC2	chr16	80966447	81020270	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6163
enhrx-106331	chr21	18264354	18264355	16892034	16892035	6057	hg38	N/A	enh34792	N/A	Enhatls113689	enhancer	E686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0025508	0.16199		CXADR	chr21	17513042	17593579	618948	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	214
enhrx-41172	chr12	98095885	98095886	97702107	97702108	6058	hg38	N/A	enh96343	N/A	Enhatls44502	enhancer	E687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13441	0.16237		NEDD1	chr12	96907223	96953780	744508	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6482
enhrx-784	chr1	6218083	6218084	6158023	6158024	6059	hg38	N/A	N/A	N/A	Enhatls821	enhancer	E688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025354	0.16237		CHD5	chr1	6101786	6180321	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	783
enhrx-140814	chr6	36613159	36613160	36645382	36645383	6060	hg38	N/A	enh23195	N/A	Enhatls150532	enhancer	E689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064847	0.16298		CDKN1A	chr6	36676459	36687337	29567	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2402
enhrx-168995	chr9	133608501	133608502	130733114	130733115	6061	hg38	N/A	enh42314	N/A	Enhatls180902	enhancer	E690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10717	0.16298		ABL1	chr9	130713042	130887675	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6262
enhrx-103166	chr20	30335603	30335604	31747800	31747801	6062	hg38	N/A	enh34601	N/A	Enhatls110300	enhancer	E691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29844	0.16314		TPX2	chr20	31739270	31801805	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1594
enhrx-168417	chr9	130732038	130732039	127969759	127969760	6063	hg38	N/A	enh26032	fant33772	Enhatls180272	enhancer	E692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077996	0.16314		EEIG1	chr9	127940581	127980989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5684
enhrx-120987	chr3	177161488	177161489	177443700	177443701	6064	hg38	N/A	enh7694	N/A	Enhatls129465	enhancer	E693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.33638	0.16343		TBL1XR1	chr3	177019343	177228000	214113	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-84534	chr19	39621903	39621904	39131263	39131264	6065	hg38	N/A	enh18060	N/A	Enhatls90616	enhancer	E694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097041	0.16402		PAK4	chr19	39125769	39182816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5504
enhrx-122093	chr3	194723019	194723020	195002290	195002291	6066	hg38	N/A	enh63259	N/A	Enhatls130677	enhancer	E695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21428	0.16402		XXYLT1	chr3	195068283	195271159	62914	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10222
enhrx-105684	chr20	60931110	60931111	62356054	62356055	6067	hg38	N/A	enh34758	N/A	Enhatls113037	enhancer	E696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13106	0.16402		LAMA5	chr20	62309064	62367312	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4112
enhrx-39859	chr12	65283863	65283864	64890083	64890084	6068	hg38	N/A	enh14788	N/A	Enhatls43089	enhancer	E697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1381	0.16402		TBC1D30	chr12	64759483	64881033	5633	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5169
enhrx-63895	chr16	53802680	53802681	53768768	53768769	6069	hg38	N/A	enh4025	fant50580	Enhatls68577	enhancer	E698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1604	0.16443		FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4190
enhrx-133272	chr5	75987074	75987075	76691249	76691250	6070	hg38	N/A	enh37987	N/A	Enhatls142392	enhancer	E699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05204	0.16443		IQGAP2	chr5	76403284	76708132	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3063
enhrx-132667	chr5	66531716	66531717	67235888	67235889	6071	hg38	N/A	enh37924	fant18781	Enhatls141777	enhancer	E700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2241	0.16443		CD180	chr5	67179612	67196799	38988	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2458
enhrx-132071	chr5	53997152	53997153	54701324	54701325	6072	hg38	N/A	enh22224	N/A	Enhatls141155	enhancer	E701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2697	0.16443		SNX18	chr5	54517758	54546586	147832	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1862
enhrx-165531	chr9	84490080	84490081	81875165	81875166	6073	hg38	N/A	enh42018	N/A	Enhatls177151	enhancer	E702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12974	0.16443		SPATA31D4	chr9	81928427	81934998	51204	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2798
enhrx-92999	chr2	97346479	97346480	96680742	96680743	6074	hg38	N/A	enh96920	N/A	Enhatls99605	enhancer	E703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01504	0.16443		FER1L5	chr2	96642763	96704887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4925
enhrx-48781	chr14	26165532	26165533	25696326	25696327	6075	hg38	N/A	N/A	N/A	Enhatls52662	enhancer	E704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22363	0.16443		STXBP6	chr14	24809453	25050147	540248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	738
enhrx-34547	chr11	130403284	130403285	130533389	130533390	6076	hg38	N/A	N/A	N/A	Enhatls37482	enhancer	E705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053479	0.16496		ADAMTS15	chr11	130448644	130476645	56696	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9216
enhrx-119582	chr3	141174875	141174876	141456033	141456034	6077	hg38	N/A	enh20995	fant13677	Enhatls127953	enhancer	E706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12288	0.16516		ZBTB38	chr3	141324212	141449792	5910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7711
enhrx-119285	chr3	135958138	135958139	136239296	136239297	6078	hg38	N/A	N/A	N/A	Enhatls127642	enhancer	E707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12786	0.16584		PCCB	chr3	136250339	136337896	5127	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7414
enhrx-119808	chr3	144043103	144043104	144324261	144324262	6079	hg38	N/A	enh82747	N/A	Enhatls128185	enhancer	E708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20989	0.16584		DIPK2A	chr3	143971822	143992368	329796	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7937
enhrx-105145	chr20	49599118	49599119	50982581	50982582	6080	hg38	N/A	enh19731	fant59096	Enhatls112448	enhancer	E709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20106	0.1669		MOCS3	chr20	50958817	50963929	18415	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3573
enhrx-115621	chr3	53118769	53118770	53084753	53084754	6081	hg38	N/A	enh65662	N/A	Enhatls123700	enhancer	E710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14544	0.1669		RFT1	chr3	53088482	53130453	1144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3750
enhrx-19937	chr10	49496144	49496145	48288101	48288102	6082	hg38	N/A	enh13195	N/A	Enhatls21897	enhancer	E711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12789	0.1669		MAPK8	chr10	48306638	48439360	10027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2372
enhrx-18140	chr10	12647847	12647848	12605848	12605849	6083	hg38	N/A	enh12994	fant34786	Enhatls19828	enhancer	E712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072023	0.1669		CAMK1D	chr10	12349546	12835545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	575
enhrx-141259	chr6	42043369	42043370	42075631	42075632	6084	hg38	N/A	N/A	N/A	Enhatls151017	enhancer	E713	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22239	0.1669		TAF8	chr6	42050512	42087461	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2847
enhrx-45829	chr13	44978565	44978566	44404429	44404430	6085	hg38	N/A	enh15271	N/A	Enhatls49464	enhancer	E714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037416	0.1669		SERP2	chr13	44373823	44397714	3241	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1451
enhrx-51703	chr14	81832749	81832750	81366405	81366406	6086	hg38	N/A	enh58596	N/A	Enhatls55759	enhancer	E715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11463	0.1669		STON2	chr14	81260651	81436465	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3660
enhrx-171424	chrX	21992273	21992274	21974155	21974156	6087	hg38	N/A	enh42471	N/A	Enhatls183445	enhancer	E716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1434	0.16737		SMS	chrX	21940708	21994837	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1141
enhrx-149131	chr7	36077080	36077081	36037470	36037471	6088	hg38	N/A	enh24101	N/A	Enhatls159394	enhancer	E717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20214	0.16767		EEPD1	chr7	36153253	36301538	111290	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1943
enhrx-149376	chr7	42144066	42144067	42104467	42104468	6089	hg38	N/A	enh24152	N/A	Enhatls159662	enhancer	E718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080326	0.16767		GLI3	chr7	41960948	42264100	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2188
enhrx-148456	chr7	22633865	22633866	22594246	22594247	6090	hg38	N/A	enh24025	N/A	Enhatls158653	enhancer	E719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20662	0.1684		STEAP1B	chr7	22419443	22632925	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1268
enhrx-32125	chr11	91821855	91821856	92088689	92088690	6091	hg38	N/A	N/A	N/A	Enhatls34895	enhancer	E720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020052	0.16961		FAT3	chr11	92224817	92896473	128884	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6794
enhrx-103530	chr20	32923719	32923720	34335913	34335914	6092	hg38	N/A	enh6365	N/A	Enhatls110693	enhancer	E721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21523	0.16973		ITCH	chr20	34363234	34511773	10746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1958
enhrx-61092	chr16	10614497	10614498	10520640	10520641	6093	hg38	N/A	enh81088	N/A	Enhatls65670	enhancer	E722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24176	0.16973		EMP2	chr16	10528421	10580598	4464	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1387
enhrx-16198	chr1	228088656	228088657	227900955	227900956	6094	hg38	N/A	enh12737	N/A	Enhatls17787	enhancer	E723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062603	0.16973		WNT9A	chr1	227918655	227947932	12462	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16197
enhrx-111478	chr22	46971018	46971019	46575121	46575122	6095	hg38	N/A	N/A	fant61672	Enhatls119298	enhancer	E724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11005	0.16973		GRAMD4	chr22	46576011	46679790	527	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3309
enhrx-31378	chr11	75000177	75000178	75289133	75289134	6096	hg38	N/A	N/A	N/A	Enhatls34107	enhancer	E725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10248	0.16973		ARRB1	chr11	75260121	75351705	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6047
enhrx-59306	chr15	93157804	93157805	92614574	92614575	6097	hg38	N/A	enh88204	N/A	Enhatls63857	enhancer	E726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014334	0.16973		FAM174B	chr15	92617447	92809798	843	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6008
enhrx-160373	chr8	96113267	96113268	95101039	95101040	6098	hg38	N/A	N/A	N/A	Enhatls171298	enhancer	E727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16501	0.16992		PLEKHF2	chr8	95115641	95156698	7501	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4164
enhrx-75029	chr17	75871318	75871319	77875236	77875237	6099	hg38	N/A	enh4619	fant53929	Enhatls80537	enhancer	E728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.255	0.16992		TNRC6C	chr17	77958702	78108822	83328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8298
enhrx-113070	chr3	24243617	24243618	24202126	24202127	6100	hg38	N/A	enh111030	N/A	Enhatls120985	enhancer	E729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086127	0.17075		THRB	chr3	24117152	24495756	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1199
enhrx-120482	chr3	160336368	160336369	160618580	160618581	6101	hg38	N/A	enh36056	N/A	Enhatls128914	enhancer	E730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1539	0.17101		KPNA4	chr3	160495006	160565571	44963	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8611
enhrx-145824	chr6	145472926	145472927	145151790	145151791	6102	hg38	N/A	N/A	N/A	Enhatls155870	enhancer	E731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16011	0.17101		EPM2A	chr6	145382534	145736023	229046	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7412
enhrx-160913	chr8	108366333	108366334	107354105	107354106	6103	hg38	N/A	enh41368	N/A	Enhatls171867	enhancer	E732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0044675	0.17107		ANGPT1	chr8	107249481	107498055	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4704
enhrx-108693	chr22	21240258	21240259	20885970	20885971	6104	hg38	N/A	enh20077	N/A	Enhatls116283	enhancer	E733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23123	0.17108		SNAP29	chr22	20859006	20891214	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	524
enhrx-43330	chr12	122192937	122192938	121755031	121755032	6105	hg38	N/A	enh80415	N/A	Enhatls46774	enhancer	E734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18323	0.17108		TMEM120B	chr12	121712751	121782068	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8640
enhrx-98450	chr2	201183839	201183840	200319116	200319117	6106	hg38	N/A	enh19112	N/A	Enhatls105328	enhancer	E735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032146	0.17108		SPATS2L	chr2	200305880	200482264	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10376
enhrx-72595	chr17	48517827	48517828	50440466	50440467	6107	hg38	N/A	enh17219	N/A	Enhatls77935	enhancer	E736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27613	0.17108		ACSF2	chr17	50426217	50474837	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5864
enhrx-15205	chr1	210650871	210650872	210477527	210477528	6108	hg38	N/A	enh95961	N/A	Enhatls16727	enhancer	E737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18031	0.17108		HHAT	chr1	210328251	210676296	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15204
enhrx-147482	chr7	2728902	2728903	2689268	2689269	6109	hg38	N/A	enh23928	fant25397	Enhatls157608	enhancer	E738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18328	0.1723		AMZ1	chr7	2679521	2719683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	294
enhrx-120699	chr3	168891230	168891231	169173442	169173443	6110	hg38	N/A	enh63229	N/A	Enhatls129145	enhancer	E739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24171	0.17245		MECOM	chr3	169083498	169663775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8828
enhrx-69389	chr17	25574624	25574625	27247598	27247599	6111	hg38	N/A	enh17059	N/A	Enhatls74488	enhancer	E740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2218	0.17338		WSB1	chr17	27294075	27315926	43987	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2658
enhrx-15731	chr1	221080451	221080452	220907109	220907110	6112	hg38	N/A	enh79385	N/A	Enhatls17270	enhancer	E741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12	0.1738		HLX	chr1	220879442	220885059	19325	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15730
enhrx-65716	chr16	75314433	75314434	75280535	75280536	6113	hg38	N/A	enh4130	N/A	Enhatls70524	enhancer	E742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014036	0.1738		CFDP1	chr16	75293709	75433503	2233	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6011
enhrx-140494	chr6	33956264	33956265	33988487	33988488	6114	hg38	N/A	enh55719	N/A	Enhatls150196	enhancer	E743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059462	0.1738		GRM4	chr6	34018642	34155622	20785	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2082
enhrx-8913	chr1	110708770	110708771	110166148	110166149	6115	hg38	N/A	N/A	N/A	Enhatls9613	enhancer	E744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21689	0.1738		SLC6A17	chr1	110150493	110202202	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8912
enhrx-403	chr1	1790908	1790909	1859469	1859470	6116	hg38	N/A	enh6	N/A	Enhatls414	enhancer	E745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17359	0.17398		GNB1	chr1	1785284	1892292	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	402
enhrx-172756	chrX	50513314	50513315	50770314	50770315	6117	hg38	N/A	enh26272	N/A	Enhatls184822	enhancer	E746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054027	0.17512		SHROOM4	chrX	50586795	50814302	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2473
enhrx-120142	chr3	152975637	152975638	153257848	153257849	6118	hg38	N/A	enh59255	N/A	Enhatls128543	enhancer	E747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16625	0.17639		RAP2B	chr3	153162225	153170627	80412	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8271
enhrx-166995	chr9	111723673	111723674	108961393	108961394	6119	hg38	N/A	enh98290	N/A	Enhatls178737	enhancer	E748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1743	0.17639		CTNNAL1	chr9	108942568	109013522	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4262
enhrx-134737	chr5	116067331	116067332	116731635	116731636	6120	hg38	N/A	enh71938	N/A	Enhatls143928	enhancer	E749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14933	0.17647		SEMA6A	chr5	116443554	116574823	154707	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4528
enhrx-164084	chr9	34375257	34375258	34375259	34375260	6121	hg38	N/A	N/A	fant32171	Enhatls175207	enhancer	E750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04934	0.17647		MYORG	chr9	34366665	34376898	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1351
enhrx-149362	chr7	40938965	40938966	40899366	40899367	6122	hg38	N/A	enh24126	N/A	Enhatls159634	enhancer	E751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12253	0.17702		SUGCT	chr7	40135004	40860763	37226	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2174
enhrx-43872	chr12	125379881	125379882	124895335	124895336	6123	hg38	N/A	enh2678	N/A	Enhatls47364	enhancer	E752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19205	0.17802		UBC	chr12	124911603	124917368	15615	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9182
enhrx-109079	chr22	24928151	24928152	24532183	24532184	6124	hg38	N/A	enh20091	N/A	Enhatls116726	enhancer	E753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1832	0.17802		UPB1	chr22	24495241	24528390	728	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	910
enhrx-85878	chr19	47122267	47122268	46619010	46619011	6125	hg38	N/A	enh44671	N/A	Enhatls92040	enhancer	E754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093256	0.17802		PTGIR	chr19	46620467	46625089	570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6848
enhrx-78797	chr18	71609672	71609673	73942437	73942438	6126	hg38	N/A	enh32833	N/A	Enhatls84539	enhancer	E755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13748	0.17892		FBXO15	chr18	74073367	74147843	122648	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2815
enhrx-7587	chr1	87666824	87666825	87201141	87201142	6127	hg38	N/A	enh12007	N/A	Enhatls8224	enhancer	E756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27405	0.17892		HS2ST1	chr1	86914634	87109982	87916	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7586
enhrx-21422	chr10	78358378	78358379	76598620	76598621	6128	hg38	N/A	N/A	N/A	Enhatls23567	enhancer	E757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044588	0.17892		LRMDA	chr10	75431623	76560168	26550	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3857
enhrx-43825	chr12	124803191	124803192	124318645	124318646	6129	hg38	N/A	N/A	N/A	Enhatls47306	enhancer	E758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062806	0.17892		RFLNA	chr12	123973240	124316024	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9135
enhrx-1179	chr1	10576489	10576490	10516432	10516433	6130	hg38	N/A	enh59	N/A	Enhatls1277	enhancer	E759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058968	0.17951		PEX14	chr1	10474949	10630758	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1178
enhrx-153113	chr7	105880034	105880035	106239588	106239589	6131	hg38	N/A	enh98048	N/A	Enhatls163630	enhancer	E760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11234	0.17963		NAMPT	chr7	106248297	106285966	6709	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5925
enhrx-40010	chr12	68800337	68800338	68406557	68406558	6132	hg38	N/A	enh14804	N/A	Enhatls43259	enhancer	E761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16667	0.17963		MDM1	chr12	68294565	68332381	74037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5320
enhrx-16856	chr1	236563020	236563021	236399720	236399721	6133	hg38	N/A	enh12813	N/A	Enhatls18457	enhancer	E762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22393	0.18009		EDARADD	chr1	236348256	236484930	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16855
enhrx-149032	chr7	33907818	33907819	33868206	33868207	6134	hg38	N/A	enh24087	N/A	Enhatls159278	enhancer	E763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18218	0.1803		BMPER	chr7	33904910	34156427	14388	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1844
enhrx-123983	chr4	32198765	32198766	32197143	32197144	6135	hg38	N/A	N/A	N/A	Enhatls132682	enhancer	E764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019617	0.1803		PCDH7	chr4	30720368	31146805	1028249	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1527
enhrx-76973	chr18	20981713	20981714	23401749	23401750	6136	hg38	N/A	enh52649	N/A	Enhatls82597	enhancer	E765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10183	0.1803		TMEM241	chr18	23296012	23437961	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	991
enhrx-122029	chr3	193902399	193902400	194184610	194184611	6137	hg38	N/A	enh21248	N/A	Enhatls130600	enhancer	E766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20972	0.1815		HES1	chr3	194136147	194138732	41325	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10158
enhrx-21169	chr10	74969602	74969603	73209844	73209845	6138	hg38	N/A	N/A	N/A	Enhatls23295	enhancer	E767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18571	0.18179		FAM149B1	chr10	73168118	73244504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3604
enhrx-156597	chr8	8319087	8319088	8461577	8461578	6139	hg38	N/A	enh24719	N/A	Enhatls167281	enhancer	E768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17151	0.18265		PRAG1	chr8	8317735	8386439	69712	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	388
enhrx-113154	chr3	27358793	27358794	27317302	27317303	6140	hg38	N/A	enh54043	N/A	Enhatls121079	enhancer	E769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000742	0.18326		NEK10	chr3	27106483	27369460	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1283
enhrx-157330	chr8	22541817	22541818	22684304	22684305	6141	hg38	N/A	enh40811	N/A	Enhatls168078	enhancer	E770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2392	0.18359		EGR3	chr8	22687658	22693480	837	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1121
enhrx-149986	chr7	51674612	51674613	51606916	51606917	6142	hg38	N/A	enh56298	N/A	Enhatls160323	enhancer	E771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063331	0.18359		COBL	chr7	51016211	51316818	287952	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2798
enhrx-172933	chrX	53389671	53389672	53362751	53362752	6143	hg38	N/A	enh98328	N/A	Enhatls185128	enhancer	E772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048755	0.18359		SMC1A	chrX	53374148	53422728	9314	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2650
enhrx-167935	chr9	125261314	125261315	122499035	122499036	6144	hg38	N/A	enh25979	N/A	Enhatls179748	enhancer	E773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096581	0.18359		OR1J2	chr9	122510801	122511743	6626	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5202
enhrx-133203	chr5	74916579	74916580	75620754	75620755	6145	hg38	N/A	enh55332	N/A	Enhatls142324	enhancer	E774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12461	0.18382		ANKDD1B	chr5	75611181	75671846	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2994
enhrx-17116	chr1	241428946	241428947	241265646	241265647	6146	hg38	N/A	enh79459	N/A	Enhatls18728	enhancer	E775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10825	0.1843		RGS7	chr1	240767635	241357374	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17115
enhrx-165672	chr9	88023606	88023607	85408691	85408692	6147	hg38	N/A	enh85458	N/A	Enhatls177300	enhancer	E776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1616	0.18512		AGTPBP1	chr9	85546538	85742029	135739	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2939
enhrx-31137	chr11	72784015	72784016	73072970	73072971	6148	hg38	N/A	enh1870	N/A	Enhatls33845	enhancer	E777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22961	0.18512		FCHSD2	chr11	72836744	73142318	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5806
enhrx-144414	chr6	113723888	113723889	113402686	113402687	6149	hg38	N/A	enh94656	N/A	Enhatls154343	enhancer	E778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14018	0.18533		MARCKS	chr6	113857344	113863475	449472	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-106995	chr21	36100987	36100988	34728689	34728690	6150	hg38	N/A	enh45209	N/A	Enhatls114398	enhancer	E779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14212	0.18534		CLIC6	chr21	34668993	34718227	8381	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	878
enhrx-14498	chr1	203655589	203655590	203686461	203686462	6151	hg38	N/A	enh12563	N/A	Enhatls15959	enhancer	E780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24519	0.18548		ATP2B4	chr1	203626831	203744081	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14497
enhrx-152058	chr7	98098584	98098585	98469272	98469273	6152	hg38	N/A	N/A	N/A	Enhatls162529	enhancer	E781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19776	0.1861		BAIAP2L1	chr7	98291649	98401090	62099	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4870
enhrx-151582	chr7	91555900	91555901	91926586	91926587	6153	hg38	N/A	N/A	N/A	Enhatls162046	enhancer	E782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12386	0.18701		AKAP9	chr7	91940839	92110673	4974	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4394
enhrx-130257	chr5	402963	402964	402848	402849	6154	hg38	N/A	enh22020	fant17721	Enhatls139237	enhancer	E783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18454	0.18701		AHRR	chr5	321713	438291	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	48
enhrx-113603	chr3	37824230	37824231	37782739	37782740	6155	hg38	N/A	N/A	N/A	Enhatls121555	enhancer	E784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25032	0.18701		ITGA9	chr3	37452114	37823507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1732
enhrx-2099	chr1	18528636	18528637	18202142	18202143	6156	hg38	N/A	enh66856	N/A	Enhatls2346	enhancer	E785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2311	0.18841		IGSF21	chr1	18107797	18378483	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2098
enhrx-129832	chr4	182742640	182742641	181821487	181821488	6157	hg38	N/A	enh37442	N/A	Enhatls138784	enhancer	E786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2276	0.18841		TENM3	chr4	182144689	182803024	311768	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7376
enhrx-158917	chr8	55471684	55471685	54559124	54559125	6158	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	E787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14956	0.18848		RP1	chr8	54559168	54871720	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2708
enhrx-64786	chr16	67606229	67606230	67572326	67572327	6159	hg38	N/A	N/A	N/A	Enhatls69541	enhancer	E788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0083311	0.18848		CTCF	chr16	67562466	67639177	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5081
enhrx-42832	chr12	116552067	116552068	116114262	116114263	6160	hg38	N/A	N/A	N/A	Enhatls46252	enhancer	E789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10825	0.18902		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-130745	chr5	11725285	11725286	11725173	11725174	6161	hg38	N/A	enh97614	N/A	Enhatls139760	enhancer	E790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28594	0.18965		CTNND2	chr5	10971835	11904446	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	536
enhrx-159305	chr8	67654119	67654120	66741884	66741885	6162	hg38	N/A	enh98115	N/A	Enhatls170171	enhancer	E791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18511	0.19146		C8orf44-SGK3	chr8	66667595	66860472	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3096
enhrx-159305	chr8	67654119	67654120	66741884	66741885	6163	hg38	N/A	enh98115	N/A	Enhatls170171	enhancer	E791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18511	0.19146		SGK3	chr8	66712780	66862022	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3096
enhrx-166953	chr9	110099435	110099436	107337154	107337155	6164	hg38	N/A	enh25848	N/A	Enhatls178690	enhancer	E792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2019	0.19146		RAD23B	chr9	107283136	107332192	1913	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4220
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6165	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHAC2	chr5	140966469	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6166	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHAC1	chr5	140926298	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6167	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA13	chr5	140882123	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6168	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA12	chr5	140875301	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6169	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA11	chr5	140868182	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6170	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA10	chr5	140855882	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6171	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA9	chr5	140847771	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6172	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA8	chr5	140841186	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6173	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA7	chr5	140834247	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6174	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA6	chr5	140827957	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6175	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA5	chr5	140821603	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6176	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA4	chr5	140807036	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6177	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA3	chr5	140801027	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6178	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA2	chr5	140794851	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140383853	140383854	141004268	141004269	6179	hg38	N/A	enh57920	N/A	Enhatls145345	enhancer	E793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13694	0.19146		PCDHA1	chr5	140786135	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-134554	chr5	111669185	111669186	112333488	112333489	6180	hg38	N/A	enh63446	N/A	Enhatls143724	enhancer	E794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16901	0.19173		EPB41L4A	chr5	112162618	112419277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4345
enhrx-140568	chr6	34921612	34921613	34953835	34953836	6181	hg38	N/A	enh9072	N/A	Enhatls150275	enhancer	E795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064622	0.19174		ANKS1A	chr6	34889254	35091406	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2156
enhrx-94664	chr2	124849930	124849931	124092353	124092354	6182	hg38	N/A	enh53283	N/A	Enhatls101365	enhancer	E796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082266	0.19206		CNTNAP5	chr2	124025286	124921219	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6590
enhrx-40734	chr12	86082868	86082869	85689090	85689091	6183	hg38	N/A	N/A	N/A	Enhatls44025	enhancer	E797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13408	0.19224		RASSF9	chr12	85800702	85836409	90596	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6044
enhrx-168078	chr9	127471110	127471111	124708831	124708832	6184	hg38	N/A	enh26000	N/A	Enhatls179902	enhancer	E798	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10552	0.19283		NR6A1	chr9	124517274	124771311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5345
enhrx-133185	chr5	74756514	74756515	75460689	75460690	6185	hg38	N/A	N/A	N/A	Enhatls142307	enhancer	E799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084395	0.19348		CERT1	chr5	75356344	75512138	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2976
enhrx-19534	chr10	43577783	43577784	43082335	43082336	6186	hg38	N/A	enh87754	N/A	Enhatls21326	enhancer	E800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08875	0.19367		RET	chr10	43077068	43130351	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1969
enhrx-165022	chr9	71720190	71720191	69105274	69105275	6187	hg38	N/A	enh56963	N/A	Enhatls176596	enhancer	E801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23189	0.19368		TJP2	chr9	69121263	69274615	9670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2289
enhrx-17722	chr10	3826263	3826264	3784071	3784072	6188	hg38	N/A	N/A	N/A	Enhatls19361	enhancer	E802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2267	0.19368		KLF6	chr10	3775995	3785281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	157
enhrx-96936	chr2	171830934	171830935	170974424	170974425	6189	hg38	N/A	enh91315	N/A	Enhatls103750	enhancer	E803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0071719	0.19457		GORASP2	chr2	170929252	170967130	6759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8862
enhrx-50570	chr14	65433898	65433899	64967180	64967181	6190	hg38	N/A	enh3282	N/A	Enhatls54546	enhancer	E804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022699	0.19491		CHURC1-FNTB	chr14	64914492	65061361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2527
enhrx-50570	chr14	65433898	65433899	64967180	64967181	6191	hg38	N/A	enh3282	N/A	Enhatls54546	enhancer	E804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022699	0.19491		RAB15	chr14	64945813	64972935	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2527
enhrx-42998	chr12	119556361	119556362	119118556	119118557	6192	hg38	N/A	N/A	N/A	Enhatls46431	enhancer	E805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14171	0.19491		SRRM4	chr12	118981540	119163051	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8308
enhrx-160682	chr8	102615946	102615947	101603718	101603719	6193	hg38	N/A	enh25184	N/A	Enhatls171630	enhancer	E806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20764	0.19491		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4473
enhrx-6580	chr1	65510239	65510240	65044556	65044557	6194	hg38	N/A	enh74249	N/A	Enhatls7170	enhancer	E807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014827	0.1956		JAK1	chr1	64833228	65067754	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6579
enhrx-15219	chr1	211287881	211287882	211114539	211114540	6195	hg38	N/A	N/A	N/A	Enhatls16741	enhancer	E808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042205	0.19581		KCNH1	chr1	210676822	211134165	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15218
enhrx-45835	chr13	45474253	45474254	44900118	44900119	6196	hg38	N/A	N/A	N/A	Enhatls49473	enhancer	E809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023909	0.19581		NUFIP1	chr13	44939248	44989471	38459	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1457
enhrx-17807	chr10	5535861	5535862	5493898	5493899	6197	hg38	N/A	enh12942	fant34528	Enhatls19452	enhancer	E810	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18247	0.19595		CALML5	chr10	5498696	5499570	4621	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	242
enhrx-65199	chr16	70333469	70333470	70299566	70299567	6198	hg38	N/A	N/A	N/A	Enhatls69975	enhancer	E811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020219	0.19595		DDX19B	chr16	70289662	70335305	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5494
enhrx-2883	chr1	24920888	24920889	24594397	24594398	6199	hg38	N/A	enh11622	N/A	Enhatls3212	enhancer	E812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20965	0.19595		NCMAP	chr1	24556086	24609328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2882
enhrx-64526	chr16	66360985	66360986	66327082	66327083	6200	hg38	N/A	enh44310	N/A	Enhatls69259	enhancer	E813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10752	0.19595		CDH5	chr16	66366690	66404784	37356	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4821
enhrx-21516	chr10	81024777	81024778	79265020	79265021	6201	hg38	N/A	enh1382	N/A	Enhatls23682	enhancer	E814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18153	0.19595		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3951
enhrx-10226	chr1	150944023	150944024	150971547	150971548	6202	hg38	N/A	enh98526	N/A	Enhatls11430	enhancer	E815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16637	0.19595		CERS2	chr1	150963669	150975003	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10225
enhrx-59555	chr15	101233908	101233909	100693703	100693704	6203	hg38	N/A	enh16472	fant49576	Enhatls64126	enhancer	E816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040284	0.19596		ASB7	chr15	100602588	100651701	41890	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6257
enhrx-59190	chr15	91417495	91417496	90874265	90874266	6204	hg38	N/A	N/A	N/A	Enhatls63741	enhancer	E817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033733	0.19732		FURIN	chr15	90868587	90883564	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5892
enhrx-125119	chr4	61804569	61804570	60938851	60938852	6205	hg38	N/A	enh21554	N/A	Enhatls133866	enhancer	E818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16951	0.19796		ADGRL3	chr4	61200325	62078335	259369	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2663
enhrx-160757	chr8	103660038	103660039	102647810	102647811	6206	hg38	N/A	enh10467	N/A	Enhatls171708	enhancer	E819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20723	0.19803		KLF10	chr8	102648783	102655725	12	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4548
enhrx-124301	chr4	40398052	40398053	40396035	40396036	6207	hg38	N/A	enh21464	N/A	Enhatls133021	enhancer	E820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11796	0.19825		RBM47	chr4	40423266	40630875	24689	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1845
enhrx-131658	chr5	39101194	39101195	39101092	39101093	6208	hg38	N/A	N/A	N/A	Enhatls140731	enhancer	E821	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13934	0.19917		FYB1	chr5	39105251	39274528	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1449
enhrx-113366	chr3	33244646	33244647	33203154	33203155	6209	hg38	N/A	enh35330	N/A	Enhatls121302	enhancer	E822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.009162	0.19967		SUSD5	chr3	33150042	33218810	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1495
enhrx-52658	chr14	101139655	101139656	100673318	100673319	6210	hg38	N/A	enh15944	N/A	Enhatls56799	enhancer	E823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07559	0.19967		DLK1	chr14	100725704	100738224	48349	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4615
enhrx-3272	chr1	27725487	27725488	27398983	27398984	6211	hg38	N/A	enh11665	N/A	Enhatls3631	enhancer	E824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016328	0.19967		GPR3	chr1	27392621	27395814	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3271
enhrx-124305	chr4	40460897	40460898	40458880	40458881	6212	hg38	N/A	enh48827	N/A	Enhatls133025	enhancer	E825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024772	0.20018		RBM47	chr4	40423266	40630875	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1849
enhrx-106067	chr20	62676842	62676843	64045489	64045490	6213	hg38	N/A	enh19819	fant59605	Enhatls113418	enhancer	E826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11883	0.20087		SOX18	chr20	64047581	64049639	2014	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4495
enhrx-136537	chr5	148833460	148833461	149453897	149453898	6214	hg38	N/A	enh22700	N/A	Enhatls145870	enhancer	E827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075262	0.20087		CSNK1A1	chr5	149492981	149551439	36962	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6328
enhrx-92381	chr2	85744266	85744267	85517143	85517144	6215	hg38	N/A	enh18703	N/A	Enhatls98978	enhancer	E828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1936	0.20087		MAT2A	chr2	85539167	85545281	19876	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-21332	chr10	75857704	75857705	74097946	74097947	6216	hg38	N/A	N/A	N/A	Enhatls23464	enhancer	E829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1014	0.20087		VCL	chr10	73998113	74121363	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3767
enhrx-43686	chr12	124003883	124003884	123519336	123519337	6217	hg38	N/A	enh15084	N/A	Enhatls47158	enhancer	E830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16286	0.20087		RILPL1	chr12	123470053	123533719	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8996
enhrx-125922	chr4	77049139	77049140	76127986	76127987	6218	hg38	N/A	N/A	N/A	Enhatls134716	enhancer	E831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11543	0.20087		NUP54	chr4	76112791	76148445	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3466
enhrx-162046	chr8	141052916	141052917	140042819	140042820	6219	hg38	N/A	enh46678	N/A	Enhatls173094	enhancer	E832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13795	0.20087		TRAPPC9	chr8	139727724	140458579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5837
enhrx-33824	chr11	119352130	119352131	119481419	119481420	6220	hg38	N/A	enh2047	N/A	Enhatls36699	enhancer	E833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19523	0.20087		THY1	chr11	119415475	119424985	52794	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8493
enhrx-77945	chr18	45834584	45834585	48308213	48308214	6221	hg38	N/A	enh17669	N/A	Enhatls83619	enhancer	E834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033814	0.20119		ZBTB7C	chr18	48026671	48410752	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1963
enhrx-116097	chr3	59650297	59650298	59664571	59664572	6222	hg38	N/A	enh63149	N/A	Enhatls124228	enhancer	E835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035611	0.20119		FHIT	chr3	59747276	61251459	80564	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4226
enhrx-13949	chr1	197589985	197589986	197620855	197620856	6223	hg38	N/A	enh50129	N/A	Enhatls15377	enhancer	E836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12426	0.20129		DENND1B	chr1	197504747	197775633	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13948
enhrx-32817	chr11	107701833	107701834	107831107	107831108	6224	hg38	N/A	enh1985	N/A	Enhatls35618	enhancer	E837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21042	0.20129		SLC35F2	chr11	107790990	107928293	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-74217	chr17	69523665	69523666	71527524	71527525	6225	hg38	N/A	N/A	N/A	Enhatls79666	enhancer	E838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23561	0.20129		SOX9	chr17	72121019	72126416	592821	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-113290	chr3	32174397	32174398	32132905	32132906	6226	hg38	N/A	N/A	N/A	Enhatls121220	enhancer	E839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23052	0.20129		GPD1L	chr3	32105688	32168709	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1419
enhrx-96961	chr2	172203124	172203125	171346614	171346615	6227	hg38	N/A	enh5963	N/A	Enhatls103776	enhancer	E840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16214	0.20129		METTL8	chr2	171315745	171434802	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8887
enhrx-40931	chr12	93628650	93628651	93234874	93234875	6228	hg38	N/A	enh80348	N/A	Enhatls44239	enhancer	E841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14725	0.20185		NUDT4	chr12	93377882	93408146	140944	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6241
enhrx-67316	chr17	4387011	4387012	4483716	4483717	6229	hg38	N/A	enh16939	N/A	Enhatls72293	enhancer	E842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22604	0.20225		SPNS3	chr17	4433939	4488204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	585
enhrx-30644	chr11	67886413	67886414	68118946	68118947	6230	hg38	N/A	enh14022	N/A	Enhatls33315	enhancer	E843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01891	0.20225		CHKA	chr11	68052858	68121444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5313
enhrx-146867	chr6	166608911	166608912	166195423	166195424	6231	hg38	N/A	enh9534	N/A	Enhatls156992	enhancer	E844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1098	0.20225		TBXT	chr6	166157655	166168700	26467	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8455
enhrx-4620	chr1	40772157	40772158	40306485	40306486	6232	hg38	N/A	N/A	N/A	Enhatls5077	enhancer	E845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033541	0.20358		COL9A2	chr1	40300488	40317286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4619
enhrx-42208	chr12	110311736	110311737	109873931	109873932	6233	hg38	N/A	enh14985	N/A	Enhatls45597	enhancer	E846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12334	0.20359		GLTP	chr12	109850944	109880541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7518
enhrx-14021	chr1	199211546	199211547	199242418	199242419	6234	hg38	N/A	enh67236	N/A	Enhatls15448	enhancer	E847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23956	0.20359		PTPRC	chr1	198638456	198757476	482742	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14020
enhrx-16205	chr1	228231379	228231380	228043678	228043679	6235	hg38	N/A	enh79415	N/A	Enhatls17794	enhancer	E848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21264	0.20359		WNT3A	chr1	228006997	228061271	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16204
enhrx-139006	chr6	15066015	15066016	15065784	15065785	6236	hg38	N/A	enh23062	N/A	Enhatls148610	enhancer	E849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24063	0.20371		JARID2	chr6	15246068	15522042	179557	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-101964	chr20	3473068	3473069	3492421	3492422	6237	hg38	N/A	enh93027	N/A	Enhatls109030	enhancer	E850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070825	0.20371		ATRN	chr20	3471017	3651118	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	392
enhrx-74213	chr17	68934627	68934628	70938486	70938487	6238	hg38	N/A	N/A	N/A	Enhatls79661	enhancer	E851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0039817	0.20371		KCNJ2	chr17	70168672	70180044	756531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7482
enhrx-127272	chr4	106554581	106554582	105633424	105633425	6239	hg38	N/A	enh105714	N/A	Enhatls136124	enhancer	E852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029801	0.20371		ARHGEF38	chr4	105552619	105680914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4816
enhrx-166236	chr9	97734801	97734802	94972519	94972520	6240	hg38	N/A	enh42102	N/A	Enhatls177922	enhancer	E853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2685	0.20401		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3503
enhrx-59099	chr15	90692755	90692756	90149523	90149524	6241	hg38	N/A	enh16414	N/A	Enhatls63639	enhancer	E854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16115	0.20457		SEMA4B	chr15	90160603	90229670	2301	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5801
enhrx-160675	chr8	102485912	102485913	101473684	101473685	6242	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20513	0.20457		GRHL2	chr8	101492438	101669726	12792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-62940	chr16	30151388	30151389	30140067	30140068	6243	hg38	N/A	enh47949	N/A	Enhatls67612	enhancer	E856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12589	0.20529		MAPK3	chr16	30114104	30123506	12519	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3235
enhrx-125515	chr4	71442656	71442657	70576939	70576940	6244	hg38	N/A	enh83139	N/A	Enhatls134279	enhancer	E857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17993	0.20529		AMBN	chr4	70592255	70607288	12458	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3059
enhrx-150346	chr7	67018536	67018537	67553549	67553550	6245	hg38	N/A	N/A	N/A	Enhatls160722	enhancer	E858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080805	0.20529		SPDYE21	chr7	67276940	67289005	231869	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3158
enhrx-10476	chr1	152365572	152365573	152393096	152393097	6246	hg38	N/A	enh58154	N/A	Enhatls11682	enhancer	E859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1006	0.20531		CRNN	chr1	152409242	152414263	8119	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10475
enhrx-77455	chr18	31276892	31276893	33696928	33696929	6247	hg38	N/A	N/A	N/A	Enhatls83111	enhancer	E860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15439	0.20631		ASXL3	chr18	33578218	33751195	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1473
enhrx-24443	chr10	123302465	123302466	121542951	121542952	6248	hg38	N/A	enh67656	N/A	Enhatls26814	enhancer	E861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1261	0.20631		FGFR2	chr10	121478331	121598458	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6878
enhrx-93294	chr2	99526043	99526044	98909580	98909581	6249	hg38	N/A	enh5724	N/A	Enhatls99924	enhancer	E862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1655	0.20635		CRACDL	chr2	98793845	98936259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5220
enhrx-160933	chr8	109272309	109272310	108260080	108260081	6250	hg38	N/A	enh73454	N/A	Enhatls171887	enhancer	E863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044342	0.20636		EIF3E	chr8	108162786	108443496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4724
enhrx-109311	chr22	27080785	27080786	26684822	26684823	6251	hg38	N/A	N/A	N/A	Enhatls116978	enhancer	E864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033697	0.20636		CRYBA4	chr22	26621962	26630669	53013	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1142
enhrx-105147	chr20	49967520	49967521	51350983	51350984	6252	hg38	N/A	enh19744	N/A	Enhatls112451	enhancer	E865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14828	0.20716		NFATC2	chr20	51386956	51562831	35934	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3575
enhrx-109318	chr22	27442257	27442258	27046295	27046296	6253	hg38	N/A	enh35008	N/A	Enhatls116986	enhancer	E866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00053004	0.20726		CRYBA4	chr22	26621962	26630669	412665	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1149
enhrx-66077	chr16	84137554	84137555	84103949	84103950	6254	hg38	N/A	enh108655	N/A	Enhatls70929	enhancer	E867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15643	0.20726		MBTPS1	chr16	84053762	84116942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6372
enhrx-103227	chr20	30628689	30628690	32040886	32040887	6255	hg38	N/A	enh6339	N/A	Enhatls110360	enhancer	E868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14101	0.20746		CCM2L	chr20	32010437	32032180	8704	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1655
enhrx-6502	chr1	64166994	64166995	63701323	63701324	6256	hg38	N/A	enh26782	N/A	Enhatls7079	enhancer	E869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037488	0.20746		PGM1	chr1	63593410	63660245	26082	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6501
enhrx-13188	chr1	181065156	181065157	181096020	181096021	6257	hg38	N/A	enh12430	N/A	Enhatls14557	enhancer	E870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22484	0.20748		IER5	chr1	181088699	181092900	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13187
enhrx-66255	chr16	86332376	86332377	86298770	86298771	6258	hg38	N/A	enh16888	N/A	Enhatls71131	enhancer	E871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15816	0.20748		FOXF1	chr16	86510526	86515422	206844	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6550
enhrx-126878	chr4	98378565	98378566	97457414	97457415	6259	hg38	N/A	enh97510	N/A	Enhatls135714	enhancer	E872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11103	0.20748		STPG2	chr4	97184092	98143476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4422
enhrx-111078	chr22	43078625	43078626	42682619	42682620	6260	hg38	N/A	enh20231	N/A	Enhatls118859	enhancer	E874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17627	0.20777		CYB5R3	chr22	42615729	42720870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2909
enhrx-70995	chr17	38732594	38732595	40576342	40576343	6261	hg38	N/A	enh48033	N/A	Enhatls76191	enhancer	E875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16229	0.20876		CCR7	chr17	40553768	40565472	8862	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4264
enhrx-18728	chr10	22972412	22972413	22683483	22683484	6262	hg38	N/A	enh27905	N/A	Enhatls20483	enhancer	E876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20281	0.2089		PIP4K2A	chr10	22534853	22714578	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1163
enhrx-21514	chr10	80943505	80943506	79183748	79183749	6263	hg38	N/A	enh1379	N/A	Enhatls23679	enhancer	E877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18829	0.20894		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-27369	chr11	21574580	21574581	21553034	21553035	6264	hg38	N/A	enh50757	N/A	Enhatls29815	enhancer	E878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10115	0.20996		NELL1	chr11	20669550	21575686	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2038
enhrx-118717	chr3	128924084	128924085	129205241	129205242	6265	hg38	N/A	enh63198	N/A	Enhatls127036	enhancer	E879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0026032	0.21087		CNBP	chr3	129167826	129183922	19289	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6846
enhrx-49201	chr14	37325466	37325467	36856261	36856262	6266	hg38	N/A	enh80770	N/A	Enhatls53102	enhancer	E880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1033	0.21087		SLC25A21	chr14	36677920	37172606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1158
enhrx-29096	chr11	60169278	60169279	60401805	60401806	6267	hg38	N/A	N/A	N/A	Enhatls31616	enhancer	E881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097128	0.2123		MS4A14	chr11	60378529	60417756	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3765
enhrx-13789	chr1	193921491	193921492	193952361	193952362	6268	hg38	N/A	enh50126	N/A	Enhatls15212	enhancer	E882	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21359	0.21329		CDC73	chr1	193122030	193254815	695421	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13788
enhrx-140814	chr6	36575601	36575602	36607824	36607825	6269	hg38	N/A	enh23193	N/A	Enhatls150531	enhancer	E883	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11731	0.21332		SRSF3	chr6	36594361	36605600	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2402
enhrx-47576	chr13	109028842	109028843	108376494	108376495	6270	hg38	N/A	N/A	N/A	Enhatls51373	enhancer	E884	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03749	0.21332		TNFSF13B	chr13	108269628	108308484	37193	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3198
enhrx-160702	chr8	103120447	103120448	102108219	102108220	6271	hg38	N/A	enh25190	fant30356	Enhatls171651	enhancer	E885	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039758	0.21356		NCALD	chr8	101686541	102124907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4493
enhrx-127393	chr4	108967106	108967107	108045950	108045951	6272	hg38	N/A	enh36907	N/A	Enhatls136252	enhancer	E886	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28329	0.214		HADH	chr4	107989713	108035174	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-64071	chr16	56849534	56849535	56815622	56815623	6273	hg38	N/A	enh4045	N/A	Enhatls68770	enhancer	E887	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086003	0.214		NUP93	chr16	56730117	56850286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4366
enhrx-21422	chr10	78318538	78318539	76558780	76558781	6274	hg38	N/A	N/A	N/A	Enhatls23567	enhancer	E888	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.088319	0.21422		LRMDA	chr10	75431623	76560168	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3857
enhrx-93470	chr2	101812912	101812913	101196450	101196451	6275	hg38	N/A	N/A	N/A	Enhatls100104	enhancer	E889	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13262	0.21423		TBC1D8	chr2	101007227	101151382	36067	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5396
enhrx-158914	chr8	55305439	55305440	54392879	54392880	6276	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	E890	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14715	0.21464		SOX17	chr8	54457934	54460892	64992	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2705
enhrx-104305	chr20	40279338	40279339	41650699	41650700	6277	hg38	N/A	enh6440	N/A	Enhatls111554	enhancer	E891	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13697	0.21478		CHD6	chr20	41402082	41618377	18850	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2733
enhrx-13237	chr1	182070724	182070725	182101589	182101590	6278	hg38	N/A	enh12433	fant3877	Enhatls14609	enhancer	E892	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11378	0.21531		ZNF648	chr1	182054569	182061712	39788	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-61606	chr16	17421736	17421737	17327879	17327880	6279	hg38	N/A	enh16578	N/A	Enhatls66215	enhancer	E893	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097454	0.21531		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-137697	chr5	174121158	174121159	174694155	174694156	6280	hg38	N/A	enh22845	N/A	Enhatls147175	enhancer	E894	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26211	0.21559		MSX2	chr5	174724581	174730896	28370	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-120987	chr3	177196424	177196425	177478636	177478637	6281	hg38	N/A	enh7694	N/A	Enhatls129465	enhancer	E895	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14211	0.21565		TBL1XR1	chr3	177019343	177228000	236275	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-163236	chr9	13034185	13034186	13034186	13034187	6282	hg38	N/A	enh85344	fant31857	Enhatls174311	enhancer	E896	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28845	0.2165		MPDZ	chr9	13105706	13279692	71154	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	503
enhrx-61166	chr16	11600298	11600299	11506442	11506443	6283	hg38	N/A	enh3888	N/A	Enhatls65750	enhancer	E897	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010008	0.21651		LITAF	chr16	11547721	11636381	39183	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1461
enhrx-46202	chr13	50819377	50819378	50245241	50245242	6284	hg38	N/A	enh2867	fant44540	Enhatls49876	enhancer	E898	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096326	0.21712		KCNRG	chr13	50015253	50020922	224023	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1824
enhrx-14917	chr1	207017220	207017221	206843875	206843876	6285	hg38	N/A	N/A	N/A	Enhatls16420	enhancer	E899	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10471	0.21712		IL19	chr1	206770763	206842981	5	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14916
enhrx-170178	chr9	140429543	140429544	137535091	137535092	6286	hg38	N/A	enh11048	N/A	Enhatls182111	enhancer	E900	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12693	0.21712		PNPLA7	chr9	137459951	137550402	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7445
enhrx-80588	chr19	7266087	7266088	7266076	7266077	6287	hg38	N/A	N/A	fant56118	Enhatls86450	enhancer	E901	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020643	0.21717		INSR	chr19	7112254	7294414	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1558
enhrx-114229	chr3	45390676	45390677	45349184	45349185	6288	hg38	N/A	N/A	N/A	Enhatls122234	enhancer	E902	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12292	0.21788		LARS2	chr3	45388560	45554726	33114	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2358
enhrx-80792	chr19	8030527	8030528	7965643	7965644	6289	hg38	N/A	N/A	N/A	Enhatls86659	enhancer	E903	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15803	0.21788		ELAVL1	chr19	7958572	8005659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1762
enhrx-88288	chr2	7172134	7172135	7032003	7032004	6290	hg38	N/A	enh81544	fant5780	Enhatls94551	enhancer	E904	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027105	0.21788		RNF144A	chr2	6917411	7068286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	214
enhrx-4695	chr1	41364366	41364367	40898694	40898695	6291	hg38	N/A	enh11779	N/A	Enhatls5152	enhancer	E905	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1276	0.21788		CITED4	chr1	40861053	40862363	33166	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4694
enhrx-95180	chr2	134399276	134399277	133641705	133641706	6292	hg38	N/A	enh18874	N/A	Enhatls101913	enhancer	E906	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094966	0.21789		NCKAP5	chr2	132671787	133568463	69792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7106
enhrx-22902	chr10	101091142	101091143	99331385	99331386	6293	hg38	N/A	N/A	N/A	Enhatls25154	enhancer	E907	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071935	0.21841		CNNM1	chr10	99329355	99394330	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5337
enhrx-37658	chr12	45862596	45862597	45468813	45468814	6294	hg38	N/A	N/A	N/A	Enhatls40776	enhancer	E908	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033711	0.21841		ANO6	chr12	45216019	45440404	24389	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2968
enhrx-34446	chr11	129194642	129194643	129324747	129324748	6295	hg38	N/A	enh14388	N/A	Enhatls37374	enhancer	E909	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14028	0.21841		ARHGAP32	chr11	128965059	129279324	36896	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9115
enhrx-69959	chr17	30170244	30170245	31843225	31843226	6296	hg38	N/A	enh62607	fant52322	Enhatls75097	enhancer	E910	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1246	0.21842		COPRS	chr17	31851870	31859244	8641	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3228
enhrx-17871	chr10	6116980	6116981	6075017	6075018	6297	hg38	N/A	enh47334	fant34578	Enhatls19527	enhancer	E911	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20442	0.21842		IL2RA	chr10	6010688	6062367	12474	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	306
enhrx-15843	chr1	223908780	223908781	223721078	223721079	6298	hg38	N/A	enh12712	N/A	Enhatls17392	enhancer	E912	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0072916	0.21842		CAPN2	chr1	223701592	223776018	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15842
enhrx-51385	chr14	75663433	75663434	75196730	75196731	6299	hg38	N/A	enh15777	N/A	Enhatls55409	enhancer	E913	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18582	0.21842		TMED10	chr14	75131468	75176612	17511	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3342
enhrx-21514	chr10	80922808	80922809	79163051	79163052	6300	hg38	N/A	enh1379	N/A	Enhatls23679	enhancer	E914	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13251	0.21842		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-11047	chr1	155974875	155974876	156005084	156005085	6301	hg38	N/A	enh79219	N/A	Enhatls12289	enhancer	E915	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25327	0.21842		ARHGEF2	chr1	155946850	156007070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11046
enhrx-8969	chr1	111653072	111653073	111110450	111110451	6302	hg38	N/A	enh95893	N/A	Enhatls9673	enhancer	E916	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17144	0.21856		DRAM2	chr1	111117162	111140203	4650	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8968
enhrx-74492	chr17	73092405	73092406	75096310	75096311	6303	hg38	N/A	N/A	N/A	Enhatls79961	enhancer	E917	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029806	0.21913		SLC16A5	chr17	75087726	75106162	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7761
enhrx-112159	chr3	9246218	9246219	9204534	9204535	6304	hg38	N/A	enh54005	N/A	Enhatls120024	enhancer	E918	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1272	0.21913		SRGAP3	chr3	8980590	9249646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	288
enhrx-40946	chr12	93930073	93930074	93536297	93536298	6305	hg38	N/A	enh43788	N/A	Enhatls44256	enhancer	E919	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021626	0.21913		MRPL42	chr12	93467513	93516214	18606	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6256
enhrx-42830	chr12	116502466	116502467	116064661	116064662	6306	hg38	N/A	enh75181	N/A	Enhatls46250	enhancer	E920	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087605	0.21913		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8140
enhrx-125996	chr4	78026334	78026335	77105181	77105182	6307	hg38	N/A	enh65855	N/A	Enhatls134799	enhancer	E921	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0070462	0.21914		CCNI	chr4	77047154	77076309	26584	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3540
enhrx-105572	chr20	60662531	60662532	62087475	62087476	6308	hg38	N/A	enh19805	N/A	Enhatls112917	enhancer	E922	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22455	0.21914		TAF4	chr20	61953468	62065881	19469	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4000
enhrx-119535	chr3	139959347	139959348	140240505	140240506	6309	hg38	N/A	N/A	N/A	Enhatls127906	enhancer	E923	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14085	0.21975		CLSTN2	chr3	139935184	140577397	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7664
enhrx-116056	chr3	58507948	58507949	58522221	58522222	6310	hg38	N/A	N/A	N/A	Enhatls124184	enhancer	E924	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094429	0.22009		ACOX2	chr3	58505135	58537283	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4185
enhrx-19606	chr10	44669202	44669203	44173754	44173755	6311	hg38	N/A	enh96068	N/A	Enhatls21411	enhancer	E925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027778	0.22009		CXCL12	chr10	44370164	44385097	194378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2041
enhrx-23737	chr10	112103236	112103237	110343478	110343479	6312	hg38	N/A	enh1499	N/A	Enhatls26055	enhancer	E926	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025977	0.2202		SMNDC1	chr10	110290729	110304920	36172	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6172
enhrx-85943	chr19	47582849	47582850	47079592	47079593	6313	hg38	N/A	N/A	N/A	Enhatls92115	enhancer	E927	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18207	0.22058		ZC3H4	chr19	47064186	47113776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6913
enhrx-34915	chr12	2255552	2255553	2146386	2146387	6314	hg38	N/A	N/A	N/A	Enhatls37890	enhancer	E928	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1413	0.22058		CACNA1C	chr12	1970771	2697950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	225
enhrx-110543	chr22	39150372	39150373	38754367	38754368	6315	hg38	N/A	N/A	N/A	Enhatls118303	enhancer	E929	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1609	0.22081		SUN2	chr22	38733289	38794143	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2374
enhrx-138606	chr6	4066866	4066867	4066632	4066633	6316	hg38	N/A	N/A	N/A	Enhatls148179	enhancer	E930	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12053	0.22081		PRP4K	chr6	4021299	4064983	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	194
enhrx-39763	chr12	64256183	64256184	63862403	63862404	6317	hg38	N/A	enh29640	N/A	Enhatls42984	enhancer	E931	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078674	0.22081		SRGAP1	chr12	63843760	64162217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5073
enhrx-15184	chr1	210053170	210053171	209879825	209879826	6318	hg38	N/A	enh27453	N/A	Enhatls16705	enhancer	E932	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1685	0.22081		UTP25	chr1	209827971	209857565	10636	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15183
enhrx-149047	chr7	34198040	34198041	34158428	34158429	6319	hg38	N/A	enh40051	N/A	Enhatls159294	enhancer	E933	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18038	0.22081		BMPER	chr7	33904910	34156427	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1859
enhrx-121292	chr3	183093877	183093878	183376089	183376090	6320	hg38	N/A	enh21153	N/A	Enhatls129789	enhancer	E934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13583	0.22081		MCF2L2	chr3	183178040	183428778	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9421
enhrx-138622	chr6	4637276	4637277	4637042	4637043	6321	hg38	N/A	enh22943	N/A	Enhatls148198	enhancer	E935	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21545	0.22081		CDYL	chr6	4706158	4955551	55858	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	210
enhrx-103484	chr20	32321813	32321814	33734007	33734008	6322	hg38	N/A	N/A	fant58430	Enhatls110639	enhancer	E936	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091517	0.22081		ZNF341	chr20	33731656	33792269	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1912
enhrx-163939	chr9	33221439	33221440	33221441	33221442	6323	hg38	N/A	enh25535	N/A	Enhatls175051	enhancer	E937	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031219	0.22081		SPINK4	chr9	33218364	33248567	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1206
enhrx-38890	chr12	54529512	54529513	54135728	54135729	6324	hg38	N/A	enh14746	N/A	Enhatls42067	enhancer	E938	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021474	0.22081		SMUG1	chr12	54180357	54188994	35814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4200
enhrx-94664	chr2	124951519	124951520	124193942	124193943	6325	hg38	N/A	N/A	N/A	Enhatls101365	enhancer	E939	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22268	0.22081		CNTNAP5	chr2	124025286	124921219	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6590
enhrx-140543	chr6	34535538	34535539	34567761	34567762	6326	hg38	N/A	enh86619	N/A	Enhatls150248	enhancer	E940	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1649	0.22081		SPDEF	chr6	34537801	34556333	5001	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2131
enhrx-172929	chrX	53292380	53292381	53263198	53263199	6327	hg38	N/A	enh63958	fant62514	Enhatls185123	enhancer	E941	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091696	0.2209		IQSEC2	chrX	53225827	53321350	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2646
enhrx-66655	chr16	89904326	89904327	89837918	89837919	6328	hg38	N/A	enh16910	fant51534	Enhatls71565	enhancer	E942	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21322	0.2209		SPIRE2	chr16	89828474	89871319	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6950
enhrx-16147	chr1	227176070	227176071	226988369	226988370	6329	hg38	N/A	enh64198	N/A	Enhatls17735	enhancer	E943	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018032	0.22179		COQ8A	chr1	226940285	226987544	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16146
enhrx-18059	chr10	11729956	11729957	11687957	11687958	6330	hg38	N/A	enh1111	N/A	Enhatls19742	enhancer	E944	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13861	0.2218		ECHDC3	chr10	11742381	11764070	48746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	494
enhrx-88306	chr2	8680247	8680248	8540117	8540118	6331	hg38	N/A	enh18236	N/A	Enhatls94581	enhancer	E945	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10919	0.2218		ID2	chr2	8678844	8684461	130456	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	232
enhrx-115165	chr3	50461097	50461098	50423666	50423667	6332	hg38	N/A	enh107930	N/A	Enhatls123213	enhancer	E946	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15529	0.2218		CACNA2D2	chr3	50362612	50504244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3294
enhrx-137358	chr5	167780424	167780425	168353419	168353420	6333	hg38	N/A	enh22780	N/A	Enhatls146786	enhancer	E947	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12392	0.22192		WWC1	chr5	168291644	168472303	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7149
enhrx-169344	chr9	136253774	136253775	133387990	133387991	6334	hg38	N/A	N/A	N/A	Enhatls181268	enhancer	E948	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21943	0.22192		STKLD1	chr9	133376365	133406096	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6611
enhrx-58915	chr15	89664785	89664786	89121554	89121555	6335	hg38	N/A	enh3782	N/A	Enhatls63447	enhancer	E949	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20839	0.22195		ABHD2	chr15	89087458	89202355	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5617
enhrx-155885	chr7	152361974	152361975	152664889	152664890	6336	hg38	N/A	enh24667	N/A	Enhatls166551	enhancer	E950	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11559	0.22338		XRCC2	chr7	152644775	152676193	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8697
enhrx-27873	chr11	34592355	34592356	34570808	34570809	6337	hg38	N/A	enh79857	N/A	Enhatls30331	enhancer	E951	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029175	0.22338		ELF5	chr11	34478790	34525193	43466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2542
enhrx-46545	chr13	65639825	65639826	65065693	65065694	6338	hg38	N/A	enh103860	N/A	Enhatls50255	enhancer	E952	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090981	0.22339		PCDH9	chr13	66302833	67230445	1235611	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2167
enhrx-110795	chr22	41397808	41397809	41001804	41001805	6339	hg38	N/A	enh20220	N/A	Enhatls118565	enhancer	E953	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15486	0.22339		RBX1	chr22	40951377	40973309	20653	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2626
enhrx-115850	chr3	56892575	56892576	56858547	56858548	6340	hg38	N/A	enh35421	N/A	Enhatls123950	enhancer	E954	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15902	0.22379		ARHGEF3	chr3	56727417	57079308	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3979
enhrx-66451	chr16	88830183	88830184	88763775	88763776	6341	hg38	N/A	enh16903	fant51453	Enhatls71348	enhancer	E955	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17686	0.22379		PIEZO1	chr16	88715337	88785220	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6746
enhrx-3191	chr1	27334739	27334740	27008248	27008249	6342	hg38	N/A	enh11657	N/A	Enhatls3544	enhancer	E956	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000219	0.2249		TENT5B	chr1	27005019	27012850	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3190
enhrx-137695	chr5	173930606	173930607	174503603	174503604	6343	hg38	N/A	enh38680	N/A	Enhatls147171	enhancer	E957	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1517	0.2249		MSX2	chr5	174724581	174730896	220421	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-102352	chr20	10166997	10166998	10186349	10186350	6344	hg38	N/A	enh82186	N/A	Enhatls109427	enhancer	E958	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12873	0.22517		SNAP25	chr20	10218829	10308258	30403	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	780
enhrx-49329	chr14	43099084	43099085	42629881	42629882	6345	hg38	N/A	N/A	N/A	Enhatls53228	enhancer	E959	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20883	0.22517		LRFN5	chr14	41606875	41904549	688124	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1286
enhrx-23105	chr10	102635664	102635665	100875907	100875908	6346	hg38	N/A	enh1467	N/A	Enhatls25366	enhancer	E960	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24313	0.22517		SLF2	chr10	100912962	100965134	12725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5540
enhrx-69637	chr17	27264525	27264526	28937507	28937508	6347	hg38	N/A	enh4318	fant52235	Enhatls74741	enhancer	E961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14437	0.22562		PHF12	chr17	28905249	28951606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2906
enhrx-113889	chr3	40459488	40459489	40417997	40417998	6348	hg38	N/A	enh82518	N/A	Enhatls121878	enhancer	E962	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19102	0.22579		ENTPD3	chr3	40387183	40428744	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2018
enhrx-161916	chr8	134806992	134806993	133794749	133794750	6349	hg38	N/A	enh56854	N/A	Enhatls172953	enhancer	E963	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13781	0.22579		ST3GAL1	chr8	133454847	133571925	219398	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5707
enhrx-15445	chr1	215083813	215083814	214910470	214910471	6350	hg38	N/A	N/A	N/A	Enhatls16979	enhancer	E964	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13087	0.2258		KCNK2	chr1	215005854	215237090	84273	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15444
enhrx-167274	chr9	114774499	114774500	112012219	112012220	6351	hg38	N/A	enh10891	fant33281	Enhatls179022	enhancer	E965	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013019	0.22622		SUSD1	chr9	112040782	112175297	28552	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4541
enhrx-161143	chr8	116711417	116711418	115699191	115699192	6352	hg38	N/A	enh115050	N/A	Enhatls172101	enhancer	E966	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086851	0.22622		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4934
enhrx-93389	chr2	100343839	100343840	99727377	99727378	6353	hg38	N/A	enh65298	N/A	Enhatls100019	enhancer	E967	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077214	0.22632		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5315
enhrx-170901	chrX	13712464	13712465	13694345	13694346	6354	hg38	N/A	enh11122	N/A	Enhatls182881	enhancer	E968	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1158	0.22632		RAB9A	chrX	13689127	13710504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	618
enhrx-9017	chr1	111963173	111963174	111420551	111420552	6355	hg38	N/A	enh12142	N/A	Enhatls9732	enhancer	E969	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15349	0.22671		OVGP1	chr1	111414318	111427735	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9016
enhrx-21514	chr10	80917533	80917534	79157776	79157777	6356	hg38	N/A	enh1379	fant36280	Enhatls23678	enhancer	E970	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24145	0.22671		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-66323	chr16	87823324	87823325	87789718	87789719	6357	hg38	N/A	enh4179	N/A	Enhatls71216	enhancer	E971	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23011	0.22671		KLHDC4	chr16	87698147	87765992	19267	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6618
enhrx-77945	chr18	45980011	45980012	48453640	48453641	6358	hg38	N/A	enh17673	N/A	Enhatls83619	enhancer	E972	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1643	0.22671		ZBTB7C	chr18	48026671	48410752	39503	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1963
enhrx-63136	chr16	31013887	31013888	31002566	31002567	6359	hg38	N/A	N/A	N/A	Enhatls67818	enhancer	E973	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24893	0.22671		STX1B	chr16	30989255	31010638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3431
enhrx-146135	chr6	152085362	152085363	151764227	151764228	6360	hg38	N/A	enh9456	fant24699	Enhatls156207	enhancer	E974	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24779	0.22671		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7723
enhrx-103806	chr20	34380827	34380828	35792905	35792906	6361	hg38	N/A	enh6378	N/A	Enhatls111012	enhancer	E975	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17096	0.22671		PHF20	chr20	35772014	35950370	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2234
enhrx-148086	chr7	12674364	12674365	12634739	12634740	6362	hg38	N/A	N/A	N/A	Enhatls158252	enhancer	E976	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22914	0.22681		SCIN	chr7	12570718	12660182	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	898
enhrx-90398	chr2	43103600	43103601	42876460	42876461	6363	hg38	N/A	enh18487	N/A	Enhatls96840	enhancer	E977	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10117	0.22681		HAAO	chr2	42767088	42792583	78163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2324
enhrx-141590	chr6	44079615	44079616	44111878	44111879	6364	hg38	N/A	enh23258	N/A	Enhatls151370	enhancer	E978	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24421	0.22681		MRPL14	chr6	44113450	44127452	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3178
enhrx-116793	chr3	95635474	95635475	95916630	95916631	6365	hg38	N/A	enh97310	N/A	Enhatls124982	enhancer	E979	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092355	0.22681		EPHA6	chr3	96814580	97761532	895830	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4922
enhrx-90580	chr2	46152808	46152809	45925669	45925670	6366	hg38	N/A	enh5483	N/A	Enhatls97039	enhancer	E980	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14169	0.22681		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2506
enhrx-16074	chr1	226260965	226260966	226073264	226073265	6367	hg38	N/A	N/A	N/A	Enhatls17647	enhancer	E981	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076426	0.22681		H3-3A	chr1	226061850	226072019	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16073
enhrx-22994	chr10	101780099	101780100	100020342	100020343	6368	hg38	N/A	enh1462	fant36778	Enhatls25246	enhancer	E982	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094341	0.22796		DNMBP	chr10	99875576	100009947	10119	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5429
enhrx-2758	chr1	24092457	24092458	23765967	23765968	6369	hg38	N/A	N/A	N/A	Enhatls3071	enhancer	E983	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24303	0.22796		ELOA	chr1	23743470	23762059	52	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2757
enhrx-122029	chr3	193868315	193868316	194150526	194150527	6370	hg38	N/A	enh63257	N/A	Enhatls130600	enhancer	E984	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19604	0.22796		HES1	chr3	194136147	194138732	9535	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10158
enhrx-13237	chr1	182309963	182309964	182340828	182340829	6371	hg38	N/A	enh12441	N/A	Enhatls14611	enhancer	E985	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16785	0.22934		GLUL	chr1	182378097	182392206	32698	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-43383	chr12	122501067	122501068	122063161	122063162	6372	hg38	N/A	enh2656	N/A	Enhatls46843	enhancer	E986	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22231	0.22967		BCL7A	chr12	122019421	122062044	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8693
enhrx-104819	chr20	45310134	45310135	46681495	46681496	6373	hg38	N/A	N/A	N/A	Enhatls112079	enhancer	E987	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17534	0.23001		SLC13A3	chr20	46557822	46684467	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3247
enhrx-148445	chr7	22274005	22274006	22234386	22234387	6374	hg38	N/A	enh89087	N/A	Enhatls158636	enhancer	E988	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1243	0.23002		RAPGEF5	chr7	22118235	22357154	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1257
enhrx-80165	chr19	4991737	4991738	4991726	4991727	6375	hg38	N/A	enh4974	N/A	Enhatls86001	enhancer	E989	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19999	0.23042		KDM4B	chr19	4969112	5153598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1135
enhrx-4845	chr1	43458213	43458214	42992542	42992543	6376	hg38	N/A	enh11805	N/A	Enhatls5318	enhancer	E990	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094219	0.23162		SLC2A1	chr1	42925352	42958868	28467	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4844
enhrx-160675	chr8	102449321	102449322	101437093	101437094	6377	hg38	N/A	enh25180	fant30332	Enhatls171623	enhancer	E991	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25762	0.23162		GRHL2	chr8	101492438	101669726	54947	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-105210	chr20	52278501	52278502	53661962	53661963	6378	hg38	N/A	enh19754	N/A	Enhatls112526	enhancer	E992	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13784	0.23162		ZNF217	chr20	53567070	53608892	52342	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3638
enhrx-141700	chr6	45472935	45472936	45505198	45505199	6379	hg38	N/A	enh39016	N/A	Enhatls151498	enhancer	E993	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19377	0.23162		RUNX2	chr6	45328316	45664349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3288
enhrx-149796	chr7	47946667	47946668	47907070	47907071	6380	hg38	N/A	N/A	N/A	Enhatls160125	enhancer	E994	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13444	0.23162		PKD1L1	chr7	47740201	47948466	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2608
enhrx-74304	chr17	71561165	71561166	73565026	73565027	6381	hg38	N/A	enh69317	N/A	Enhatls79770	enhancer	E995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096295	0.23309		SDK2	chr17	73334383	73644445	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7573
enhrx-119180	chr3	133561885	133561886	133843041	133843042	6382	hg38	N/A	N/A	N/A	Enhatls127536	enhancer	E996	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018946	0.23309		RAB6B	chr3	133824234	133895882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7309
enhrx-49802	chr14	53367578	53367579	52900860	52900861	6383	hg38	N/A	enh15617	N/A	Enhatls53735	enhancer	E997	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090303	0.23309		FERMT2	chr14	52857267	52952435	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1759
enhrx-77459	chr18	31383026	31383027	33803062	33803063	6384	hg38	N/A	enh4758	N/A	Enhatls83115	enhancer	E998	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023019	0.23309		NOL4	chr18	33851099	34224913	41569	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1477
enhrx-128974	chr4	154354481	154354482	153433329	153433330	6385	hg38	N/A	enh8285	N/A	Enhatls137895	enhancer	E999	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076091	0.23309		MND1	chr4	153344648	153415118	11687	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6518
enhrx-137252	chr5	160315001	160315002	160887994	160887995	6386	hg38	N/A	enh22767	N/A	Enhatls146676	enhancer	E1000	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042646	0.23347		ATP10B	chr5	160563119	160852211	31000	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7043
enhrx-97602	chr2	182411060	182411061	181546333	181546334	6387	hg38	N/A	N/A	N/A	Enhatls104448	enhancer	E1001	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21667	0.23479		CERKL	chr2	181535040	181680665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9528
enhrx-113296	chr3	32257779	32257780	32216287	32216288	6388	hg38	N/A	enh54056	N/A	Enhatls121226	enhancer	E1002	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12776	0.23597		CMTM8	chr3	32238678	32370321	16456	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1425
enhrx-36854	chr12	27163023	27163024	27010090	27010091	6389	hg38	N/A	enh2241	N/A	Enhatls39947	enhancer	E1003	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13944	0.23601		TM7SF3	chr12	26971578	27014434	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-64835	chr16	67786776	67786777	67752873	67752874	6390	hg38	N/A	N/A	N/A	Enhatls69590	enhancer	E1004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14878	0.23659		RANBP10	chr16	67723069	67806560	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5130
enhrx-146963	chr6	167810220	167810221	167396732	167396733	6391	hg38	N/A	enh56105	N/A	N/A	enhancer	E1005	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022016	0.23681		TTLL2	chr6	167325070	167342688	51910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8551
enhrx-142673	chr6	71584427	71584428	70874724	70874725	6392	hg38	N/A	N/A	N/A	Enhatls152518	enhancer	E1006	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067857	0.23681		B3GAT2	chr6	70856678	70957060	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4261
enhrx-161150	chr8	117652307	117652308	116640068	116640069	6393	hg38	N/A	enh10482	N/A	Enhatls172116	enhancer	E1007	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047139	0.23681		EIF3H	chr8	116642129	116766925	994	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4941
enhrx-75667	chr17	79694741	79694742	81727711	81727712	6394	hg38	N/A	enh17447	N/A	N/A	enhancer	E1008	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087058	0.23704		SLC25A10	chr17	81712235	81721016	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8936
enhrx-75290	chr17	77795310	77795311	79821511	79821512	6395	hg38	N/A	enh4626	N/A	Enhatls80817	enhancer	E1009	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17592	0.23704		CBX4	chr17	79833155	79839440	888	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8559
enhrx-13066	chr1	179775129	179775130	179805994	179805995	6396	hg38	N/A	N/A	N/A	Enhatls14432	enhancer	E1010	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16347	0.23704		FAM163A	chr1	179743290	179816198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13065
enhrx-83786	chr19	35808555	35808556	35317652	35317653	6397	hg38	N/A	enh5106	fant56865	Enhatls89848	enhancer	E1011	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0095679	0.23704		CD22	chr19	35319260	35347361	1453	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4756
enhrx-114284	chr3	45821936	45821937	45780444	45780445	6398	hg38	N/A	N/A	N/A	Enhatls122295	enhancer	E1012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08028	0.23704		SLC6A20	chr3	45755448	45796574	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2413
enhrx-20474	chr10	64605270	64605271	62845510	62845511	6399	hg38	N/A	enh96093	N/A	Enhatls22560	enhancer	E1013	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16933	0.23704		EGR2	chr10	62811995	62818659	25920	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2909
enhrx-72292	chr17	46599749	46599750	48522387	48522388	6400	hg38	N/A	enh17197	N/A	Enhatls77604	enhancer	E1014	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07317	0.23704		HOXB1	chr17	48528525	48531011	3993	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5561
enhrx-982	chr1	8950094	8950095	8890035	8890036	6401	hg38	N/A	enh26520	N/A	Enhatls1056	enhancer	E1015	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078916	0.23704		ENO1	chr1	8860999	8879190	7981	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	981
enhrx-11868	chr1	161231415	161231416	161261625	161261626	6402	hg38	N/A	N/A	N/A	Enhatls13149	enhancer	E1016	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27006	0.23704		PCP4L1	chr1	161258744	161285450	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11867
enhrx-62177	chr16	22244286	22244287	22232965	22232966	6403	hg38	N/A	enh3940	N/A	Enhatls66802	enhancer	E1017	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10907	0.23826		EEF2K	chr16	22206277	22288738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2472
enhrx-24969	chr10	130967580	130967581	129169316	129169317	6404	hg38	N/A	enh67675	N/A	Enhatls27330	enhancer	E1018	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097847	0.23928		MGMT	chr10	129467189	129770983	296699	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7404
enhrx-149729	chr7	47207992	47207993	47168394	47168395	6405	hg38	N/A	N/A	N/A	Enhatls160039	enhancer	E1019	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024797	0.23954		TNS3	chr7	47275153	47582558	106532	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-10498	chr1	152715848	152715849	152743372	152743373	6406	hg38	N/A	enh12266	N/A	Enhatls11703	enhancer	E1020	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1553	0.23954		KPRP	chr1	152758024	152762056	10172	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10497
enhrx-16181	chr1	227616730	227616731	227429029	227429030	6407	hg38	N/A	enh12733	N/A	Enhatls17769	enhancer	E1021	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14519	0.24042		CDC42BPA	chr1	226989864	227318492	108353	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16180
enhrx-49220	chr14	38036360	38036361	37567155	37567156	6408	hg38	N/A	enh68684	N/A	Enhatls53121	enhancer	E1022	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097897	0.24042		MIPOL1	chr14	37197893	37564746	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1177
enhrx-104871	chr20	46135329	46135330	47506585	47506586	6409	hg38	N/A	enh60940	N/A	Enhatls112131	enhancer	E1023	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058573	0.24042		NCOA3	chr20	47501886	47656877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3299
enhrx-145281	chr6	133281996	133281997	132960857	132960858	6410	hg38	N/A	enh46219	N/A	Enhatls155250	enhancer	E1024	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15761	0.24127		RPS12	chr6	132814568	132817564	141010	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6869
enhrx-93389	chr2	100317085	100317086	99700623	99700624	6411	hg38	N/A	enh33508	N/A	Enhatls100018	enhancer	E1025	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27198	0.24127		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5315
enhrx-142505	chr6	67697030	67697031	66987137	66987138	6412	hg38	N/A	enh84234	N/A	Enhatls152349	enhancer	E1026	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15921	0.24127		EYS	chr6	63719979	65707226	1276647	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4093
enhrx-16503	chr1	231275826	231275827	231140080	231140081	6413	hg38	N/A	enh12778	N/A	Enhatls18094	enhancer	E1027	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23605	0.24127		TRIM67	chr1	231162057	231221565	18969	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16502
enhrx-57526	chr15	72477206	72477207	72184865	72184866	6414	hg38	N/A	enh16309	N/A	Enhatls61893	enhancer	E1028	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13255	0.24127		GRAMD2A	chr15	72159805	72197787	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-128776	chr4	149227217	149227218	148306065	148306066	6415	hg38	N/A	enh88876	N/A	Enhatls137687	enhancer	E1029	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28426	0.24127		NR3C2	chr4	148078761	148444698	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6320
enhrx-94915	chr2	129352875	129352876	128595301	128595302	6416	hg38	N/A	enh53301	N/A	Enhatls101626	enhancer	E1030	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09553	0.24137		HS6ST1	chr2	128265479	128318868	271045	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6841
enhrx-157849	chr8	29437443	29437444	29579927	29579928	6417	hg38	N/A	enh10215	N/A	Enhatls168631	enhancer	E1031	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032731	0.24137		DUSP4	chr8	29333063	29350684	226826	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-148845	chr7	30711606	30711607	30671990	30671991	6418	hg38	hs2636	N/A	N/A	Enhatls159078	enhancer	E1032	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18386	0.24137		CRHR2	chr7	30651941	30700103	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1657
enhrx-42208	chr12	110302334	110302335	109864529	109864530	6419	hg38	N/A	enh14985	N/A	Enhatls45597	enhancer	E1033	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015619	0.24137		GLTP	chr12	109850944	109880541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7518
enhrx-81485	chr19	11287656	11287657	11176980	11176981	6420	hg38	N/A	N/A	N/A	Enhatls87363	enhancer	E1034	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0028569	0.24137		KANK2	chr19	11164269	11197548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2455
enhrx-23960	chr10	115681914	115681915	113922155	113922156	6421	hg38	N/A	enh13523	N/A	Enhatls26304	enhancer	E1035	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13078	0.24137		NHLRC2	chr10	113854660	113917194	1853	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6395
enhrx-130213	chr5	57259	57260	57144	57145	6422	hg38	N/A	enh71613	N/A	N/A	enhancer	E1036	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20772	0.24137		PLEKHG4B	chr5	92167	189972	32881	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4
enhrx-157122	chr8	21124008	21124009	21266497	21266498	6423	hg38	N/A	N/A	N/A	Enhatls167852	enhancer	E1037	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062959	0.24153		GFRA2	chr8	21690397	21812357	397169	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	913
enhrx-49643	chr14	51341727	51341728	50875009	50875010	6424	hg38	N/A	enh92531	N/A	Enhatls53560	enhancer	E1038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14642	0.2416		PYGL	chr14	50857890	50944483	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1600
enhrx-49643	chr14	51341727	51341728	50875009	50875010	6425	hg38	N/A	enh92531	N/A	Enhatls53560	enhancer	E1038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14642	0.2416		ABHD12B	chr14	50872052	50904970	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1600
enhrx-127393	chr4	108980024	108980025	108058868	108058869	6426	hg38	N/A	enh54910	N/A	Enhatls136253	enhancer	E1039	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01806	0.2416		LEF1	chr4	108047544	108168956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-109370	chr22	29156117	29156118	28760129	28760130	6427	hg38	N/A	enh20113	N/A	Enhatls117043	enhancer	E1040	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068884	0.24163		HSCB	chr22	28742038	28757515	323	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1201
enhrx-112490	chr3	12491712	12491713	12450213	12450214	6428	hg38	N/A	enh20341	N/A	Enhatls120372	enhancer	E1041	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11765	0.24278		PPARG	chr3	12287367	12434356	171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	619
enhrx-49223	chr14	38088165	38088166	37618960	37618961	6429	hg38	N/A	enh92521	N/A	Enhatls53123	enhancer	E1042	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087746	0.24278		TTC6	chr14	37595628	37842717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-42612	chr12	113277386	113277387	112839581	112839582	6430	hg38	N/A	enh29987	fant43160	Enhatls46032	enhancer	E1043	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18801	0.24304		RPH3A	chr12	112570379	112898881	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7922
enhrx-70107	chr17	31414097	31414098	33087079	33087080	6431	hg38	N/A	N/A	N/A	Enhatls75242	enhancer	E1044	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098897	0.24305		ASIC2	chr17	33013086	34157294	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3376
enhrx-104905	chr20	46786934	46786935	48158191	48158192	6432	hg38	N/A	enh19682	N/A	Enhatls112171	enhancer	E1045	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080861	0.2431		SULF2	chr20	47656911	47786616	367279	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3333
enhrx-106294	chr21	16235867	16235868	14863546	14863547	6433	hg38	N/A	enh19821	N/A	Enhatls113648	enhancer	E1046	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084263	0.24401		NRIP1	chr21	14961234	15065815	97578	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	177
enhrx-127405	chr4	109402203	109402204	108481047	108481048	6434	hg38	N/A	enh105727	N/A	Enhatls136265	enhancer	E1047	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16479	0.24436		RPL34	chr4	108620568	108630412	134670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4949
enhrx-41057	chr12	95939836	95939837	95546060	95546061	6435	hg38	N/A	N/A	N/A	Enhatls44382	enhancer	E1048	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080727	0.24469		USP44	chr12	95516559	95551476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6367
enhrx-10458	chr1	152007710	152007711	152035234	152035235	6436	hg38	N/A	enh625	fant3119	Enhatls11665	enhancer	E1049	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14691	0.24469		S100A11	chr1	152032505	152037004	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10457
enhrx-8969	chr1	111588040	111588041	111045418	111045419	6437	hg38	N/A	enh92095	N/A	Enhatls9673	enhancer	E1050	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13436	0.24469		DRAM2	chr1	111117162	111140203	69410	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8968
enhrx-121844	chr3	189155970	189155971	189438181	189438182	6438	hg38	N/A	N/A	N/A	Enhatls130397	enhancer	E1051	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17541	0.24469		TPRG1	chr3	188947213	189325304	105963	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9973
enhrx-134395	chr5	107251895	107251896	107916194	107916195	6439	hg38	N/A	N/A	N/A	Enhatls143564	enhancer	E1052	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12364	0.24488		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4186
enhrx-73844	chr17	64513660	64513661	66517542	66517543	6440	hg38	N/A	N/A	N/A	Enhatls79278	enhancer	E1053	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16423	0.24488		PRKCA	chr17	66302612	66810743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7113
enhrx-173102	chrX	54774333	54774334	54747900	54747901	6441	hg38	N/A	N/A	N/A	Enhatls185297	enhancer	E1054	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16078	0.24488		ITIH6	chrX	54748917	54798255	21	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2819
enhrx-151127	chr7	79039774	79039775	79410458	79410459	6442	hg38	N/A	N/A	N/A	Enhatls161563	enhancer	E1055	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1197	0.24488		MAGI2	chr7	78017054	79453667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3939
enhrx-172180	chrX	44775025	44775026	44915780	44915781	6443	hg38	N/A	enh11191	N/A	Enhatls184223	enhancer	E1056	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045647	0.24488		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1897
enhrx-139000	chr6	14001843	14001844	14001612	14001613	6444	hg38	N/A	enh38809	N/A	Enhatls148601	enhancer	E1057	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10859	0.24488		RNF182	chr6	13924445	13980310	18245	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	588
enhrx-19237	chr10	32649438	32649439	32360510	32360511	6445	hg38	N/A	enh1164	N/A	Enhatls21029	enhancer	E1058	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064388	0.24488		EPC1	chr10	32267750	32378798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1672
enhrx-34388	chr11	126914649	126914650	127044754	127044755	6446	hg38	N/A	N/A	N/A	Enhatls37305	enhancer	E1059	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14637	0.24488		KIRREL3	chr11	126423357	127000810	43891	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9057
enhrx-120867	chr3	171931954	171931955	172214164	172214165	6447	hg38	N/A	enh21112	N/A	Enhatls129332	enhancer	E1060	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15352	0.24488		FNDC3B	chr3	172039577	172401669	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8996
enhrx-35645	chr12	8791721	8791722	8639125	8639126	6448	hg38	N/A	enh14511	N/A	Enhatls38686	enhancer	E1062	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30331	0.24546		MFAP5	chr12	8637345	8662884	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-21178	chr10	75023848	75023849	73264090	73264091	6449	hg38	N/A	enh43336	N/A	Enhatls23303	enhancer	E1063	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19245	0.24584		CFAP70	chr10	73253761	73358864	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3613
enhrx-83382	chr19	30176549	30176550	29685642	29685643	6450	hg38	N/A	enh18007	N/A	Enhatls89432	enhancer	E1064	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084329	0.24584		C19orf12	chr19	29698936	29715789	2069	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4352
enhrx-157995	chr8	33715024	33715025	33857506	33857507	6451	hg38	N/A	N/A	N/A	Enhatls168801	enhancer	E1065	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19331	0.24584		DUSP26	chr8	33591329	33600023	249455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1786
enhrx-50286	chr14	61905863	61905864	61439145	61439146	6452	hg38	N/A	enh15658	N/A	Enhatls54244	enhancer	E1066	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19156	0.24584		PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2243
enhrx-13701	chr1	190480891	190480892	190511761	190511762	6453	hg38	N/A	N/A	N/A	Enhatls15123	enhancer	E1067	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14824	0.24584		BRINP3	chr1	190097657	190477864	4767	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13700
enhrx-30810	chr11	69914330	69914331	70068224	70068225	6454	hg38	N/A	enh14041	N/A	N/A	enhancer	E1068	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067335	0.24614		ANO1	chr11	69985906	70189530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5479
enhrx-16771	chr1	235877666	235877667	235714366	235714367	6455	hg38	N/A	N/A	N/A	Enhatls18373	enhancer	E1069	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26731	0.24615		LYST	chr1	235661040	235883724	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16770
enhrx-165243	chr9	76533963	76533964	73919047	73919048	6456	hg38	N/A	N/A	N/A	Enhatls176842	enhancer	E1070	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049796	0.24743		RORB	chr9	74497334	74693177	566426	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2510
enhrx-118228	chr3	123151866	123151867	123433019	123433020	6457	hg38	N/A	N/A	N/A	Enhatls126502	enhancer	E1071	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11849	0.24743		ADCY5	chr3	123282295	123449090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6357
enhrx-120987	chr3	177292179	177292180	177574391	177574392	6458	hg38	N/A	enh63242	N/A	Enhatls129466	enhancer	E1072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20542	0.24772		TBL1XR1	chr3	177019343	177228000	337982	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-65222	chr16	70424801	70424802	70390898	70390899	6459	hg38	N/A	enh16758	N/A	Enhatls69998	enhancer	E1073	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023839	0.24772		ST3GAL2	chr16	70375976	70439100	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5517
enhrx-112883	chr3	16518282	16518283	16476775	16476776	6460	hg38	N/A	enh7031	N/A	Enhatls120790	enhancer	E1074	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22957	0.24786		RFTN1	chr3	16315844	16514026	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1012
enhrx-75471	chr17	78639756	78639757	80665956	80665957	6461	hg38	N/A	enh4633	N/A	Enhatls80992	enhancer	E1075	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10451	0.24786		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-15255	chr1	211817335	211817336	211643993	211643994	6462	hg38	N/A	enh12635	N/A	Enhatls16777	enhancer	E1076	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13323	0.24786		NEK2	chr1	211658656	211675630	8235	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15254
enhrx-56360	chr15	57798277	57798278	57506079	57506080	6463	hg38	N/A	enh16164	fant48290	Enhatls60639	enhancer	E1077	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040325	0.24797		CGNL1	chr15	57376504	57550717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3062
enhrx-14454	chr1	203069764	203069765	203100636	203100637	6464	hg38	N/A	enh12547	N/A	Enhatls15909	enhancer	E1078	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11873	0.24797		ADORA1	chr1	203090653	203167405	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14453
enhrx-31304	chr11	74257970	74257971	74546925	74546926	6465	hg38	N/A	enh50887	N/A	Enhatls34023	enhancer	E1079	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051716	0.24797		POLD3	chr11	74493850	74669117	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5973
enhrx-106012	chr20	62387923	62387924	63756570	63756571	6466	hg38	N/A	N/A	N/A	Enhatls113359	enhancer	E1080	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078149	0.24797		ZBTB46	chr20	63743667	63831264	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4440
enhrx-40832	chr12	89619867	89619868	89226090	89226091	6467	hg38	N/A	enh14864	fant42516	Enhatls44126	enhancer	E1081	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1509	0.24797		DUSP6	chr12	89347234	89352501	120895	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6142
enhrx-166153	chr9	96358032	96358033	93595750	93595751	6468	hg38	N/A	enh10836	N/A	Enhatls177829	enhancer	E1082	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01795	0.24797		PHF2	chr9	93576583	93679587	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3420
enhrx-143617	chr6	93652454	93652455	92942736	92942737	6469	hg38	N/A	enh84293	N/A	Enhatls153495	enhancer	E1083	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095992	0.24886		EPHA7	chr6	93240019	93419588	295223	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5205
enhrx-46958	chr13	89410019	89410020	88757765	88757766	6470	hg38	N/A	N/A	N/A	Enhatls50705	enhancer	E1084	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15423	0.24891		SLITRK5	chr13	87671370	87696272	1055850	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2580
enhrx-47614	chr13	110651170	110651171	109998823	109998824	6471	hg38	N/A	enh30700	N/A	Enhatls51417	enhancer	E1085	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10076	0.24892		COL4A1	chr13	110148962	110307157	144815	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3236
enhrx-61606	chr16	17506267	17506268	17412410	17412411	6472	hg38	N/A	enh3924	N/A	Enhatls66216	enhancer	E1086	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045517	0.24892		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-62615	chr16	28336106	28336107	28324785	28324786	6473	hg38	N/A	N/A	N/A	Enhatls67274	enhancer	E1087	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17995	0.24909		SBK1	chr16	28259245	28323849	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2910
enhrx-130158	chr4	188276180	188276181	187355026	187355027	6474	hg38	N/A	enh83519	N/A	Enhatls139146	enhancer	E1088	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010489	0.24979		FAT1	chr4	186587793	186726722	626130	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7702
enhrx-71677	chr17	41975367	41975368	43897999	43898000	6475	hg38	N/A	N/A	N/A	Enhatls76919	enhancer	E1089	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23147	0.2498		MPP2	chr17	43875356	43909711	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4946
enhrx-124723	chr4	49002401	49002402	49000384	49000385	6476	hg38	N/A	N/A	N/A	Enhatls133452	enhancer	E1090	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041527	0.25095		CWH43	chr4	48986274	49062079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2267
enhrx-132332	chr5	58413302	58413303	59117475	59117476	6477	hg38	N/A	enh110202	N/A	Enhatls141428	enhancer	E1091	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023187	0.25095		PDE4D	chr5	58969037	60488076	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2123
enhrx-159838	chr8	82556232	82556233	81643997	81643998	6478	hg38	N/A	enh85063	N/A	Enhatls170740	enhancer	E1092	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0087817	0.25095		IMPA1	chr8	81656913	81686331	10814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3629
enhrx-31936	chr11	86651373	86651374	86940331	86940332	6479	hg38	N/A	N/A	N/A	Enhatls34697	enhancer	E1093	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11886	0.25095		PRSS23	chr11	86791058	86952910	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6605
enhrx-33312	chr11	116620770	116620771	116750054	116750055	6480	hg38	N/A	N/A	N/A	Enhatls36148	enhancer	E1094	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20649	0.25095		BUD13	chr11	116748169	116772987	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7981
enhrx-161283	chr8	120989878	120989879	119977638	119977639	6481	hg38	N/A	enh10495	N/A	Enhatls172256	enhancer	E1095	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0006316	0.25095		DEPTOR	chr8	119873716	120050918	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5074
enhrx-19675	chr10	46142262	46142263	45646814	45646815	6482	hg38	N/A	N/A	N/A	Enhatls21490	enhancer	E1096	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23591	0.25095		ZFAND4	chr10	45615499	45672772	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2110
enhrx-121209	chr3	182426687	182426688	182708899	182708900	6483	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	E1097	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23509	0.25188		ATP11B	chr3	182793502	182921629	69547	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9338
enhrx-52446	chr14	96633926	96633927	96167589	96167590	6484	hg38	N/A	enh15910	N/A	Enhatls56568	enhancer	E1098	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1895	0.25188		BDKRB2	chr14	96204678	96244166	33021	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4403
enhrx-17666	chr10	1282420	1282421	1240357	1240358	6485	hg38	N/A	N/A	N/A	Enhatls19303	enhancer	E1099	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15619	0.25188		ADARB2	chr10	1177312	1737525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	101
enhrx-121780	chr3	186692797	186692798	186975009	186975010	6486	hg38	N/A	enh7749	N/A	Enhatls130322	enhancer	E1100	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17553	0.25289		ST6GAL1	chr3	186930525	187078553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9909
enhrx-112657	chr3	14285440	14285441	14243940	14243941	6487	hg38	N/A	enh20365	N/A	Enhatls120552	enhancer	E1101	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14265	0.25289		LSM3	chr3	14178816	14201122	40744	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	786
enhrx-168507	chr9	131058056	131058057	128295777	128295778	6488	hg38	N/A	N/A	N/A	Enhatls180363	enhancer	E1102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0087243	0.25289		SWI5	chr9	128275378	128288990	5582	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5774
enhrx-66210	chr16	85456574	85456575	85422968	85422969	6489	hg38	N/A	enh16869	fant51269	Enhatls71076	enhancer	E1103	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10479	0.25449		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-81829	chr19	13162552	13162553	13051738	13051739	6490	hg38	N/A	enh17930	N/A	Enhatls87724	enhancer	E1104	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086141	0.25456		NFIX	chr19	12995474	13098796	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2799
enhrx-15721	chr1	220971955	220971956	220798613	220798614	6491	hg38	N/A	enh64185	N/A	Enhatls17263	enhancer	E1105	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1858	0.25456		MTARC1	chr1	220786351	220819659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15720
enhrx-31800	chr11	83122130	83122131	83411087	83411088	6492	hg38	N/A	enh87909	N/A	Enhatls34554	enhancer	E1106	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27084	0.25513		DLG2	chr11	83455011	85628335	41580	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6469
enhrx-166233	chr9	97581809	97581810	94819527	94819528	6493	hg38	N/A	enh10841	N/A	Enhatls177916	enhancer	E1107	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016379	0.25513		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3500
enhrx-43317	chr12	122071308	122071309	121633402	121633403	6494	hg38	N/A	enh2647	N/A	Enhatls46762	enhancer	E1108	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2273	0.25639		ORAI1	chr12	121626549	121642040	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8627
enhrx-51399	chr14	76021129	76021130	75554786	75554787	6495	hg38	N/A	enh15784	N/A	Enhatls55423	enhancer	E1109	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059544	0.25639		BATF	chr14	75522468	75546993	2476	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3356
enhrx-78442	chr18	59463608	59463609	61796375	61796376	6496	hg38	N/A	N/A	N/A	Enhatls84161	enhancer	E1110	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17326	0.25776		RNF152	chr18	61808066	61894231	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2460
enhrx-137719	chr5	175236942	175236943	175809939	175809940	6497	hg38	N/A	N/A	N/A	Enhatls147199	enhancer	E1111	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085255	0.25837		CPLX2	chr5	175796309	175884021	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7510
enhrx-51747	chr14	87699825	87699826	87233481	87233482	6498	hg38	N/A	enh3379	N/A	Enhatls55808	enhancer	E1112	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17491	0.25837		GALC	chr14	87933013	87993665	692616	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3704
enhrx-105203	chr20	51875461	51875462	53258922	53258923	6499	hg38	N/A	N/A	N/A	Enhatls112514	enhancer	E1113	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034688	0.2585		TSHZ2	chr20	52972357	53495330	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3631
enhrx-10380	chr1	151521468	151521469	151548992	151548993	6500	hg38	N/A	enh12251	N/A	Enhatls11580	enhancer	E1114	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03419	0.2589		TUFT1	chr1	151540304	151583583	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10379
enhrx-82934	chr19	18948366	18948367	18837557	18837558	6501	hg38	N/A	enh17979	N/A	Enhatls88956	enhancer	E1115	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22677	0.2589		UPF1	chr19	18831958	18868230	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3904
enhrx-74228	chr17	70178899	70178900	72182758	72182759	6502	hg38	N/A	enh96768	N/A	Enhatls79685	enhancer	E1116	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025893	0.2589		SOX9	chr17	72121019	72126416	54249	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-109749	chr22	31575510	31575511	31179524	31179525	6503	hg38	N/A	enh6819	N/A	Enhatls117426	enhancer	E1117	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17229	0.2589		RNF185	chr22	31160181	31207019	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1580
enhrx-63916	chr16	55420950	55420951	55387038	55387039	6504	hg38	N/A	N/A	N/A	Enhatls68601	enhancer	E1118	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10633	0.26079		MMP2	chr16	55389699	55506691	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4211
enhrx-99057	chr2	207947538	207947539	207082814	207082815	6505	hg38	N/A	enh62902	N/A	Enhatls105984	enhancer	E1119	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13899	0.26095		KLF7	chr2	207074136	207173856	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10983
enhrx-136548	chr5	148941157	148941158	149561594	149561595	6506	hg38	N/A	enh8790	N/A	Enhatls145881	enhancer	E1120	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11997	0.26095		ARHGEF37	chr5	149551946	149634968	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6339
enhrx-117913	chr3	120275235	120275236	120556388	120556389	6507	hg38	N/A	enh20847	N/A	Enhatls126186	enhancer	E1121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11891	0.26095		NDUFB4	chr3	120596327	120602507	35989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6042
enhrx-6127	chr1	56882222	56882223	56416550	56416551	6508	hg38	N/A	enh11909	N/A	Enhatls6671	enhancer	E1122	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2006	0.26095		PLPP3	chr1	56494760	56579563	74238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6126
enhrx-137394	chr5	168005712	168005713	168578707	168578708	6509	hg38	N/A	N/A	N/A	Enhatls146825	enhancer	E1123	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036876	0.26119		PANK3	chr5	168548494	168579368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7185
enhrx-143266	chr6	85063992	85063993	84354274	84354275	6510	hg38	N/A	N/A	N/A	Enhatls153133	enhancer	E1124	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094192	0.26205		CEP162	chr6	84124240	84227643	107295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4854
enhrx-159693	chr8	75250581	75250582	74338346	74338347	6511	hg38	N/A	enh98123	N/A	Enhatls170579	enhancer	E1125	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16667	0.26206		GDAP1	chr8	74320612	74494697	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3484
enhrx-103264	chr20	30844546	30844547	32256743	32256744	6512	hg38	N/A	enh53748	N/A	Enhatls110398	enhancer	E1126	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1016	0.26339		POFUT1	chr20	32207879	32238658	14524	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1692
enhrx-30644	chr11	67874306	67874307	68106839	68106840	6513	hg38	N/A	enh28842	N/A	Enhatls33315	enhancer	E1127	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14993	0.26437		CHKA	chr11	68052858	68121444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5313
enhrx-141590	chr6	44017394	44017395	44049657	44049658	6514	hg38	N/A	enh9138	N/A	Enhatls151369	enhancer	E1128	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10006	0.26437		MRPL14	chr6	44113450	44127452	61839	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3178
enhrx-57384	chr15	69761132	69761133	69468793	69468794	6515	hg38	N/A	enh44141	N/A	Enhatls61742	enhancer	E1129	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041287	0.26589		RPLP1	chr15	69452813	69456205	3842	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4086
enhrx-112657	chr3	14378067	14378068	14336567	14336568	6516	hg38	N/A	enh20368	N/A	Enhatls120552	enhancer	E1130	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1552	0.26589		SLC6A6	chr3	14402575	14489349	54601	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	786
enhrx-111116	chr22	43511158	43511159	43115152	43115153	6517	hg38	N/A	enh61007	N/A	Enhatls118903	enhancer	E1131	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10637	0.2664		BIK	chr22	43110749	43129712	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2947
enhrx-75572	chr17	79339722	79339723	81365922	81365923	6518	hg38	N/A	enh32378	fant54207	Enhatls81109	enhancer	E1132	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079103	0.2664		BAHCC1	chr17	81395456	81466331	29149	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8841
enhrx-66210	chr16	85322765	85322766	85289159	85289160	6519	hg38	N/A	enh16865	N/A	Enhatls71075	enhancer	E1133	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039466	0.2664		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-153088	chr7	105580747	105580748	105940301	105940302	6520	hg38	N/A	enh46445	N/A	Enhatls163606	enhancer	E1134	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022932	0.2664		CDHR3	chr7	105963258	106036432	20910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5900
enhrx-103162	chr20	30307356	30307357	31719553	31719554	6521	hg38	N/A	N/A	N/A	Enhatls110296	enhancer	E1135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095756	0.2664		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-2136	chr1	19337160	19337161	19010666	19010667	6522	hg38	N/A	enh11568	N/A	Enhatls2387	enhancer	E1136	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04527	0.2664		IFFO2	chr1	18904279	18956676	53545	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-167267	chr9	114619981	114619982	111857701	111857702	6523	hg38	N/A	enh46841	N/A	Enhatls179014	enhancer	E1137	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17433	0.26641		UGCG	chr9	111896813	111935369	37015	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4534
enhrx-160677	chr8	102517054	102517055	101504826	101504827	6524	hg38	N/A	enh25182	fant30340	Enhatls171624	enhancer	E1138	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21667	0.26641		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-159190	chr8	64013829	64013830	63101270	63101271	6525	hg38	N/A	N/A	N/A	Enhatls170047	enhancer	E1139	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11934	0.26693		TTPA	chr8	63059487	63086053	5089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2981
enhrx-60117	chr16	1623445	1623446	1573444	1573445	6526	hg38	N/A	N/A	N/A	Enhatls64664	enhancer	E1140	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19733	0.26742		IFT140	chr16	1510426	1612072	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	412
enhrx-112657	chr3	14307276	14307277	14265776	14265777	6527	hg38	N/A	enh20366	N/A	Enhatls120552	enhancer	E1141	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014863	0.26763		LSM3	chr3	14178816	14201122	57976	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	786
enhrx-137293	chr5	162688831	162688832	163261825	163261826	6528	hg38	N/A	N/A	N/A	Enhatls146720	enhancer	E1142	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17911	0.26763		CCNG1	chr5	163437568	163445016	169830	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7084
enhrx-24252	chr10	119368752	119368753	117609241	117609242	6529	hg38	N/A	enh28492	N/A	Enhatls26605	enhancer	E1143	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1005	0.26763		EMX2	chr10	117542444	117549546	57339	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6687
enhrx-61606	chr16	17493779	17493780	17399922	17399923	6530	hg38	N/A	enh3923	N/A	Enhatls66216	enhancer	E1144	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.30942	0.2688		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-48804	chr14	28589277	28589278	28120071	28120072	6531	hg38	N/A	enh96481	N/A	Enhatls52692	enhancer	E1145	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051681	0.2688		FOXG1	chr14	28764328	28770277	642490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	761
enhrx-134530	chr5	111502351	111502352	112166654	112166655	6532	hg38	N/A	N/A	N/A	Enhatls143700	enhancer	E1146	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22697	0.2688		EPB41L4A	chr5	112162618	112419277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4321
enhrx-27945	chr11	35991492	35991493	35969942	35969943	6533	hg38	N/A	enh64454	N/A	Enhatls30413	enhancer	E1147	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17698	0.2688		LDLRAD3	chr11	35943980	36232136	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2614
enhrx-102572	chr20	17586126	17586127	17605481	17605482	6534	hg38	N/A	N/A	N/A	Enhatls109673	enhancer	E1148	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079266	0.2688		DSTN	chr20	17570074	17609919	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1000
enhrx-57404	chr15	70386057	70386058	70093718	70093719	6535	hg38	N/A	enh16280	N/A	Enhatls61769	enhancer	E1149	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042213	0.2688		TLE3	chr15	70047789	70098176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4106
enhrx-136179	chr5	142100287	142100288	142720722	142720723	6536	hg38	N/A	enh22663	N/A	Enhatls145480	enhancer	E1150	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14615	0.2688		FGF1	chr5	142592177	142698070	13232	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5970
enhrx-7799	chr1	92040782	92040783	91575225	91575226	6537	hg38	N/A	enh12030	N/A	Enhatls8434	enhancer	E1151	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039958	0.26924		CDC7	chr1	91500850	91525764	46579	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7798
enhrx-123337	chr4	8353804	8353805	8352077	8352078	6538	hg38	N/A	enh36338	N/A	Enhatls131994	enhancer	E1152	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010981	0.26924		ACOX3	chr4	8366281	8440723	11652	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	881
enhrx-16643	chr1	233850716	233850717	233714970	233714971	6539	hg38	N/A	enh109397	N/A	Enhatls18237	enhancer	E1153	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13622	0.26924		KCNK1	chr1	233614105	233672514	40606	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16642
enhrx-139612	chr6	28291877	28291878	28324100	28324101	6540	hg38	N/A	N/A	N/A	Enhatls149246	enhancer	E1154	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19274	0.26924		ZSCAN31	chr6	28324736	28356271	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1200
enhrx-49824	chr14	54718198	54718199	54251480	54251481	6541	hg38	N/A	enh30904	N/A	Enhatls53756	enhancer	E1155	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10592	0.26924		CDKN3	chr14	54396978	54420218	141020	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1781
enhrx-158373	chr8	40240407	40240408	40382888	40382889	6542	hg38	N/A	N/A	N/A	Enhatls169206	enhancer	E1156	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058875	0.26924		ZMAT4	chr8	40530589	40897833	143544	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-162043	chr8	140921003	140921004	139908759	139908760	6543	hg38	N/A	N/A	N/A	Enhatls173091	enhancer	E1157	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10511	0.26924		TRAPPC9	chr8	139727724	140458579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5834
enhrx-82252	chr19	15673817	15673818	15563006	15563007	6544	hg38	N/A	enh76114	N/A	Enhatls88194	enhancer	E1158	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18926	0.27194		CYP4F22	chr19	15508524	15552317	8558	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3222
enhrx-72233	chr17	45982726	45982727	47905360	47905361	6545	hg38	N/A	enh32219	N/A	Enhatls77536	enhancer	E1159	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15128	0.27197		SP2	chr17	47896149	47928957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5502
enhrx-49016	chr14	34412876	34412877	33943670	33943671	6546	hg38	N/A	enh47754	N/A	Enhatls52918	enhancer	E1160	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019755	0.27197		EGLN3	chr14	33924226	34222877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	973
enhrx-31930	chr11	86417585	86417586	86706543	86706544	6547	hg38	N/A	enh96243	N/A	Enhatls34690	enhancer	E1161	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079806	0.27241		ME3	chr11	86441107	86672618	31866	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6599
enhrx-52623	chr14	100671056	100671057	100204719	100204720	6548	hg38	N/A	enh15939	N/A	Enhatls56762	enhancer	E1162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0058753	0.27241		YY1	chr14	100238297	100282788	29940	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4580
enhrx-32447	chr11	101312635	101312636	101441904	101441905	6549	hg38	N/A	enh29049	fant39698	Enhatls35232	enhancer	E1163	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.129	0.27265		TRPC6	chr11	101451563	101584007	9603	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7116
enhrx-161917	chr8	135014162	135014163	134001919	134001920	6550	hg38	N/A	N/A	N/A	Enhatls172957	enhancer	E1164	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080236	0.27265		ST3GAL1	chr8	133454847	133571925	403788	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5708
enhrx-136537	chr5	148865532	148865533	149485969	149485970	6551	hg38	N/A	enh22701	N/A	Enhatls145870	enhancer	E1165	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079588	0.27302		CSNK1A1	chr5	149492981	149551439	1068	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6328
enhrx-153250	chr7	107590142	107590143	107949697	107949698	6552	hg38	N/A	enh66444	N/A	Enhatls163768	enhancer	E1166	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16293	0.27361		LAMB1	chr7	107923798	108003213	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6062
enhrx-167086	chr9	113012067	113012068	110249787	110249788	6553	hg38	N/A	enh25902	N/A	Enhatls178835	enhancer	E1167	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17253	0.27448		TXN	chr9	110243809	110256507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4353
enhrx-134745	chr5	117583559	117583560	118247864	118247865	6554	hg38	N/A	enh61292	N/A	Enhatls143940	enhancer	E1168	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081563	0.27462		DTWD2	chr5	118836073	118988547	584434	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4536
enhrx-31486	chr11	76547458	76547459	76836414	76836415	6555	hg38	N/A	enh14116	N/A	Enhatls34227	enhancer	E1169	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18068	0.27462		ACER3	chr11	76860858	77026797	18708	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6155
enhrx-98895	chr2	204333875	204333876	203469152	203469153	6556	hg38	N/A	N/A	N/A	Enhatls105815	enhancer	E1170	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09759	0.2749		RAPH1	chr2	203394344	203535335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10821
enhrx-121556	chr3	184354863	184354864	184637075	184637076	6557	hg38	N/A	enh21163	N/A	Enhatls130067	enhancer	E1171	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04765	0.2749		EPHB3	chr3	184561784	184582408	50710	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9685
enhrx-119382	chr3	137920791	137920792	138201949	138201950	6558	hg38	N/A	enh91473	N/A	Enhatls127747	enhancer	E1172	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013713	0.2749		ARMC8	chr3	138187247	138298384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7511
enhrx-161146	chr8	117098421	117098422	116086196	116086197	6559	hg38	N/A	enh73475	N/A	Enhatls172110	enhancer	E1173	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050406	0.27565		TRPS1	chr8	115408495	115809673	274348	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-22077	chr10	92996136	92996137	91236379	91236380	6560	hg38	N/A	N/A	N/A	Enhatls24284	enhancer	E1174	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24813	0.27565		PCGF5	chr10	91163011	91284337	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4512
enhrx-89992	chr2	36008949	36008950	35783883	35783884	6561	hg38	N/A	enh96882	N/A	Enhatls96398	enhancer	E1175	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073519	0.27565		CRIM1	chr2	36355777	36551135	569869	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1918
enhrx-161916	chr8	134837224	134837225	133824981	133824982	6562	hg38	N/A	N/A	N/A	Enhatls172953	enhancer	E1176	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27298	0.27565		ST3GAL1	chr8	133454847	133571925	247008	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5707
enhrx-23796	chr10	112867778	112867779	111108020	111108021	6563	hg38	N/A	enh87805	N/A	Enhatls26118	enhancer	E1177	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14841	0.27593		ADRA2A	chr10	111077028	111080907	24261	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6231
enhrx-62496	chr16	27180969	27180970	27169648	27169649	6564	hg38	N/A	enh31749	N/A	Enhatls67134	enhancer	E1178	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13793	0.27593		KDM8	chr16	27203525	27221768	29481	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2791
enhrx-21513	chr10	80855287	80855288	79095530	79095531	6565	hg38	N/A	enh1378	N/A	Enhatls23676	enhancer	E1179	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080475	0.27593		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3948
enhrx-69959	chr17	29926237	29926238	31599218	31599219	6566	hg38	N/A	enh17097	N/A	Enhatls75097	enhancer	E1180	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12147	0.27593		RAB11FIP4	chr17	31391674	31538211	58695	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3228
enhrx-102703	chr20	19377618	19377619	19396974	19396975	6567	hg38	N/A	enh76655	N/A	Enhatls109817	enhancer	E1181	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043225	0.27668		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1131
enhrx-104828	chr20	45619327	45619328	46990688	46990689	6568	hg38	N/A	enh48521	N/A	Enhatls112087	enhancer	E1182	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.31566	0.27668		EYA2	chr20	46894623	47188844	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3256
enhrx-46631	chr13	73640293	73640294	73066155	73066156	6569	hg38	N/A	enh30434	N/A	Enhatls50347	enhancer	E1183	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.034327	0.27674		KLF5	chr13	73054975	73077541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2253
enhrx-34687	chr11	134367652	134367653	134497758	134497759	6570	hg38	N/A	enh109533	N/A	Enhatls37637	enhancer	E1184	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15872	0.27674		B3GAT1	chr11	134378505	134412242	83450	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9356
enhrx-40486	chr12	80101747	80101748	79707967	79707968	6571	hg38	N/A	enh14848	N/A	Enhatls43761	enhancer	E1185	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05912	0.27674		PAWR	chr12	79584878	79690964	14256	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5796
enhrx-167686	chr9	121767151	121767152	119004873	119004874	6572	hg38	N/A	enh42255	N/A	Enhatls179472	enhancer	E1186	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037611	0.27674		BRINP1	chr9	119166628	119369435	159472	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4953
enhrx-20507	chr10	65482474	65482475	63722714	63722715	6573	hg38	N/A	enh1253	N/A	Enhatls22596	enhancer	E1187	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16164	0.27674		REEP3	chr10	63521400	63625128	82518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2942
enhrx-54337	chr15	35220115	35220116	34927914	34927915	6574	hg38	N/A	N/A	N/A	Enhatls58521	enhancer	E1188	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061843	0.27674		AQR	chr15	34851781	34969742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1039
enhrx-72870	chr17	54815744	54815745	56738383	56738384	6575	hg38	N/A	N/A	N/A	Enhatls78222	enhancer	E1189	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11874	0.27674		C17orf67	chr17	56791912	56833920	43914	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6139
enhrx-21514	chr10	80888871	80888872	79129114	79129115	6576	hg38	N/A	enh1379	N/A	Enhatls23677	enhancer	E1190	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16451	0.27674		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-151675	chr7	92089629	92089630	92460315	92460316	6577	hg38	N/A	enh24318	N/A	Enhatls162139	enhancer	E1191	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14906	0.27674		GATAD1	chr7	92447481	92460075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4487
enhrx-122029	chr3	193894691	193894692	194176902	194176903	6578	hg38	N/A	enh21247	N/A	Enhatls130600	enhancer	E1193	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20526	0.27796		HES1	chr3	194136147	194138732	26025	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10158
enhrx-89294	chr2	26995474	26995475	26772606	26772607	6579	hg38	N/A	enh18372	N/A	Enhatls95652	enhancer	E1194	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14785	0.27857		SLC35F6	chr2	26764283	26781231	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1220
enhrx-70860	chr17	37968942	37968943	39812689	39812690	6580	hg38	N/A	enh4404	N/A	Enhatls76028	enhancer	E1195	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19216	0.2792		IKZF3	chr17	39757717	39864312	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4129
enhrx-69784	chr17	28580526	28580527	30253508	30253509	6581	hg38	N/A	enh17086	N/A	Enhatls74916	enhancer	E1196	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15122	0.27956		BLMH	chr17	30248202	30292042	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3053
enhrx-138584	chr6	3349234	3349235	3349000	3349001	6582	hg38	N/A	enh8925	N/A	Enhatls148153	enhancer	E1197	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17919	0.27975		SLC22A23	chr6	3268961	3457050	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	172
enhrx-57095	chr15	66125151	66125152	65832813	65832814	6583	hg38	N/A	enh16247	fant48559	Enhatls61428	enhancer	E1198	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11319	0.28041		RAB11A	chr15	65869455	65891989	36486	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3797
enhrx-47614	chr13	110667359	110667360	110015012	110015013	6584	hg38	N/A	enh30702	N/A	Enhatls51417	enhancer	E1199	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083359	0.28056		COL4A1	chr13	110148962	110307157	131522	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3236
enhrx-143950	chr6	105808013	105808014	105360138	105360139	6585	hg38	N/A	enh23447	N/A	Enhatls153826	enhancer	E1200	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035656	0.28056		PREP	chr6	105273217	105454062	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5538
enhrx-141846	chr6	47638309	47638310	47670573	47670574	6586	hg38	N/A	enh39037	N/A	Enhatls151651	enhancer	E1201	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24485	0.28056		ADGRF4	chr6	47685863	47722021	12729	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3434
enhrx-172107	chrX	41819530	41819531	41960277	41960278	6587	hg38	N/A	N/A	N/A	Enhatls184148	enhancer	E1202	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061067	0.28074		CASK	chrX	41514933	41923554	25912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1824
enhrx-34339	chr11	126000311	126000312	126130416	126130417	6588	hg38	N/A	enh14372	N/A	Enhatls37246	enhancer	E1203	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16264	0.28074		CDON	chr11	125955795	126063335	66879	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-65059	chr16	69332817	69332818	69298914	69298915	6589	hg38	N/A	N/A	N/A	Enhatls69824	enhancer	E1204	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21231	0.28263		SNTB2	chr16	69187163	69309052	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5354
enhrx-85774	chr19	46246469	46246470	45743211	45743212	6590	hg38	N/A	N/A	N/A	Enhatls91920	enhancer	E1205	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18442	0.28263		MEIOSIN	chr19	45733438	45764541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6744
enhrx-90579	chr2	46005903	46005904	45778764	45778765	6591	hg38	N/A	enh5478	N/A	Enhatls97038	enhancer	E1206	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16736	0.28263		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2505
enhrx-23341	chr10	104381531	104381532	102621774	102621775	6592	hg38	N/A	enh13462	N/A	Enhatls25620	enhancer	E1207	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096497	0.28263		SUFU	chr10	102503971	102633535	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5776
enhrx-93058	chr2	97554476	97554477	96888739	96888740	6593	hg38	N/A	enh18736	fant7851	Enhatls99669	enhancer	E1208	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1565	0.28367		FAM178B	chr2	96875881	96986580	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4984
enhrx-140957	chr6	38118671	38118672	38150895	38150896	6594	hg38	N/A	enh89008	N/A	Enhatls150693	enhancer	E1209	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10709	0.28367		ZFAND3	chr6	37819726	38154624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2545
enhrx-110599	chr22	39570999	39571000	39174994	39174995	6595	hg38	N/A	enh20209	fant61348	Enhatls118360	enhancer	E1210	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0067539	0.28434		CBX7	chr22	39130771	39152680	22030	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2430
enhrx-19858	chr10	48342894	48342895	47396466	47396467	6596	hg38	N/A	enh13191	N/A	Enhatls21763	enhancer	E1211	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029681	0.28529		ZNF488	chr10	47365495	47384293	9947	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2293
enhrx-137670	chr5	172908133	172908134	173481130	173481131	6597	hg38	N/A	N/A	N/A	Enhatls147138	enhancer	E1212	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15843	0.28529		BOD1	chr5	173607144	173616653	125596	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7461
enhrx-118316	chr3	124223799	124223800	124504952	124504953	6598	hg38	N/A	N/A	N/A	Enhatls126597	enhancer	E1213	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0056476	0.28529		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6445
enhrx-142132	chr6	52977459	52977460	53112661	53112662	6599	hg38	N/A	enh23310	N/A	Enhatls151950	enhancer	E1214	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066583	0.28553		FBXO9	chr6	53051990	53100873	4035	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3720
enhrx-161932	chr8	135766495	135766496	134754252	134754253	6600	hg38	N/A	enh25368	N/A	Enhatls172977	enhancer	E1215	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085107	0.28553		ZFAT	chr8	134477787	134713031	39172	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5723
enhrx-148896	chr7	31311416	31311417	31271802	31271803	6601	hg38	N/A	enh78169	N/A	Enhatls159136	enhancer	E1216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11239	0.28605		NEUROD6	chr7	31337464	31340726	63584	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1708
enhrx-95202	chr2	135581182	135581183	134823612	134823613	6602	hg38	N/A	enh33688	N/A	Enhatls101938	enhancer	E1217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082027	0.28605		ACMSD	chr2	134838615	134902034	12931	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-93486	chr2	101944413	101944414	101327951	101327952	6603	hg38	N/A	enh18760	N/A	Enhatls100117	enhancer	E1218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10134	0.28618		RNF149	chr2	101275600	101308701	17123	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5412
enhrx-22595	chr10	98015367	98015368	96255610	96255611	6604	hg38	N/A	N/A	N/A	Enhatls24842	enhancer	E1219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096022	0.28618		BLNK	chr10	96189170	96271569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5030
enhrx-159800	chr8	81169410	81169411	80257175	80257176	6605	hg38	N/A	enh25087	N/A	Enhatls170701	enhancer	E1220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22124	0.28673		TPD52	chr8	80034744	80171564	73067	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3591
enhrx-106725	chr21	33630822	33630823	32258511	32258512	6606	hg38	N/A	enh34870	N/A	Enhatls114111	enhancer	E1221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073455	0.28694		MIS18A	chr21	32268227	32279049	7492	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	608
enhrx-66210	chr16	85604279	85604280	85570673	85570674	6607	hg38	N/A	enh16872	fant51285	Enhatls71076	enhancer	E1222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11747	0.28694		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-168214	chr9	129436192	129436193	126673913	126673914	6608	hg38	N/A	enh26010	N/A	Enhatls180049	enhancer	E1223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10067	0.28694		LMX1B	chr9	126613927	126701032	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5481
enhrx-52770	chr14	102651945	102651946	102185608	102185609	6609	hg38	N/A	enh3461	N/A	Enhatls56910	enhancer	E1224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11251	0.28694		WDR20	chr14	102139843	102224847	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4727
enhrx-24239	chr10	119039195	119039196	117279684	117279685	6610	hg38	N/A	N/A	N/A	Enhatls26595	enhancer	E1225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.069877	0.28694		PDZD8	chr10	117277273	117375440	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6674
enhrx-78328	chr18	55891067	55891068	58223835	58223836	6611	hg38	N/A	enh32734	fant55282	Enhatls84031	enhancer	E1226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080089	0.28694		NEDD4L	chr18	58044225	58401540	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2346
enhrx-33259	chr11	114104584	114104585	114233862	114233863	6612	hg38	N/A	enh62211	N/A	Enhatls36092	enhancer	E1227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.29107	0.28707		ZBTB16	chr11	114059040	114256765	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7928
enhrx-91381	chr2	65017441	65017442	64790307	64790308	6613	hg38	N/A	enh5590	N/A	Enhatls97914	enhancer	E1228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14052	0.28707		SERTAD2	chr2	64631620	64653913	119836	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3307
enhrx-52540	chr14	98854709	98854710	98388372	98388373	6614	hg38	N/A	N/A	N/A	Enhatls56668	enhancer	E1229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050803	0.28707		BCL11B	chr14	99169286	99272197	766679	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4497
enhrx-14295	chr1	202032474	202032475	202063346	202063347	6615	hg38	N/A	enh12534	N/A	Enhatls15738	enhancer	E1230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017146	0.28749		GPR37L1	chr1	202122885	202133592	37825	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14294
enhrx-34707	chr12	301075	301076	191909	191910	6616	hg38	N/A	N/A	N/A	Enhatls37665	enhancer	E1231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061905	0.28749		SLC6A12	chr12	190076	214157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17
enhrx-166924	chr9	109432877	109432878	106670596	106670597	6617	hg38	N/A	N/A	N/A	Enhatls178659	enhancer	E1232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23268	0.28749		ZNF462	chr9	106863165	107013634	191764	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4191
enhrx-122026	chr3	193640290	193640291	193922501	193922502	6618	hg38	N/A	enh77188	N/A	Enhatls130592	enhancer	E1233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090522	0.28819		HES1	chr3	194136147	194138732	204502	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10155
enhrx-29141	chr11	60508246	60508247	60740773	60740774	6619	hg38	N/A	N/A	N/A	Enhatls31661	enhancer	E1234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0070034	0.28822		MS4A18	chr11	60724719	60745028	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3810
enhrx-14543	chr1	204053579	204053580	204084451	204084452	6620	hg38	N/A	enh12573	N/A	Enhatls16009	enhancer	E1235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13284	0.28822		SOX13	chr1	204073114	204127743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14542
enhrx-131160	chr5	32331473	32331474	32331367	32331368	6621	hg38	N/A	enh8416	N/A	Enhatls140194	enhancer	E1236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13908	0.28822		MTMR12	chr5	32226993	32312969	10171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	951
enhrx-42805	chr12	116360995	116360996	115923190	115923191	6622	hg38	N/A	N/A	N/A	Enhatls46225	enhancer	E1237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19148	0.28822		MED13L	chr12	115958575	116277693	33865	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8115
enhrx-160675	chr8	102479477	102479478	101467249	101467250	6623	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E1238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03384	0.28905		GRHL2	chr8	101492438	101669726	12792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-34339	chr11	126017805	126017806	126147910	126147911	6624	hg38	N/A	enh2087	N/A	Enhatls37246	enhancer	E1239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11687	0.28952		RPUSD4	chr11	126202095	126211692	42586	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-16123	chr1	226859220	226859221	226671519	226671520	6625	hg38	N/A	enh973	N/A	Enhatls17704	enhancer	E1240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067236	0.28953		ITPKB	chr1	226631689	226739323	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16122
enhrx-163852	chr9	32137044	32137045	32137046	32137047	6626	hg38	N/A	enh93794	N/A	Enhatls174965	enhancer	E1241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040392	0.28953		ACO1	chr9	32384602	32454769	245646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1119
enhrx-58621	chr15	84422794	84422795	83754042	83754043	6627	hg38	N/A	enh81044	N/A	Enhatls63120	enhancer	E1242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18907	0.28962		ADAMTSL3	chr15	83654087	84039842	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5323
enhrx-96742	chr2	170114779	170114780	169258269	169258270	6628	hg38	N/A	N/A	N/A	Enhatls103552	enhancer	E1243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11972	0.28962		LRP2	chr2	169127108	169362534	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8668
enhrx-63011	chr16	30500218	30500219	30488897	30488898	6629	hg38	N/A	enh89801	N/A	Enhatls67687	enhancer	E1244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03849	0.28962		ITGAL	chr16	30472728	30523185	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3306
enhrx-150361	chr7	70203198	70203199	70738212	70738213	6630	hg38	N/A	enh9860	N/A	Enhatls160737	enhancer	E1245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080027	0.28962		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3173
enhrx-112928	chr3	17938433	17938434	17896941	17896942	6631	hg38	N/A	N/A	N/A	Enhatls120836	enhancer	E1246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1028	0.28962		TBC1D5	chr3	17157161	17742652	145347	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1057
enhrx-49821	chr14	53771986	53771987	53305268	53305269	6632	hg38	N/A	enh43997	N/A	Enhatls53753	enhancer	E1247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11274	0.29087		DDHD1	chr14	53036744	53153323	151094	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1778
enhrx-7807	chr1	92202574	92202575	91737017	91737018	6633	hg38	N/A	enh12035	N/A	Enhatls8446	enhancer	E1248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068935	0.29087		TGFBR3	chr1	91680342	91906335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7806
enhrx-2469	chr1	21665346	21665347	21338853	21338854	6634	hg38	N/A	enh110	N/A	Enhatls2743	enhancer	E1249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18472	0.29087		ECE1	chr1	21217246	21345572	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2468
enhrx-170900	chrX	13687546	13687547	13669427	13669428	6635	hg38	N/A	enh11121	fant62016	Enhatls182880	enhancer	E1250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097517	0.29111		TCEANC	chrX	13653111	13665409	3818	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	617
enhrx-89578	chr2	28939372	28939373	28716506	28716507	6636	hg38	N/A	enh18396	fant6413	Enhatls95960	enhancer	E1251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043207	0.29111		PPP1CB	chr2	28751639	28802940	34942	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1504
enhrx-108510	chr22	19731448	19731449	19743925	19743926	6637	hg38	N/A	enh95082	N/A	Enhatls116042	enhancer	E1252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06517	0.29111		TBX1	chr22	19756702	19783593	9725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	341
enhrx-50784	chr14	69036781	69036782	68570064	68570065	6638	hg38	N/A	enh15717	N/A	Enhatls54768	enhancer	E1253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0014521	0.29111		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2741
enhrx-135889	chr5	138709568	138709569	139373879	139373880	6639	hg38	N/A	enh86597	N/A	Enhatls145168	enhancer	E1254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10817	0.29111		SLC23A1	chr5	139367195	139384553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5680
enhrx-166057	chr9	95428608	95428609	92666326	92666327	6640	hg38	N/A	enh25758	N/A	Enhatls177722	enhancer	E1255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03805	0.29111		IPPK	chr9	92613182	92670131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3324
enhrx-11040	chr1	155914715	155914716	155944924	155944925	6641	hg38	N/A	enh656	N/A	Enhatls12273	enhancer	E1256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13996	0.29111		RXFP4	chr1	155941637	155943087	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11039
enhrx-49017	chr14	34582568	34582569	34113362	34113363	6642	hg38	N/A	enh15565	N/A	Enhatls52919	enhancer	E1257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092845	0.29111		EGLN3	chr14	33924226	34222877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	974
enhrx-36291	chr12	16016496	16016497	15863562	15863563	6643	hg38	N/A	N/A	N/A	Enhatls39361	enhancer	E1258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027569	0.2917		EPS8	chr12	15620133	15882329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1601
enhrx-102856	chr20	21923557	21923558	21942919	21942920	6644	hg38	N/A	N/A	N/A	Enhatls109979	enhancer	E1259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027029	0.29258		PAX1	chr20	21705658	21718481	220588	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1284
enhrx-22919	chr10	101210879	101210880	99451122	99451123	6645	hg38	N/A	enh67596	N/A	Enhatls25171	enhancer	E1260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10358	0.29258		GOT1	chr10	99396869	99430624	17725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5354
enhrx-167782	chr9	123748192	123748193	120985914	120985915	6646	hg38	N/A	enh93837	N/A	Enhatls179580	enhancer	E1261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037769	0.29258		C5	chr9	120932986	121075195	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5049
enhrx-137324	chr5	164484379	164484380	165057373	165057374	6647	hg38	N/A	N/A	N/A	Enhatls146750	enhancer	E1262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24286	0.29258		MAT2B	chr5	163503113	163519558	1512172	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7115
enhrx-44624	chr13	22103820	22103821	21529681	21529682	6648	hg38	N/A	enh15133	N/A	Enhatls48145	enhancer	E1263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16572	0.29258		MICU2	chr13	21492690	21604181	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	246
enhrx-20334	chr10	61082959	61082960	59323199	59323200	6649	hg38	N/A	N/A	N/A	Enhatls22397	enhancer	E1264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12542	0.29258		FAM13C	chr10	59246129	59363181	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2769
enhrx-51911	chr14	90557894	90557895	90091550	90091551	6650	hg38	N/A	enh80914	N/A	Enhatls55973	enhancer	E1265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09221	0.29258		KCNK13	chr14	90061993	90185853	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3868
enhrx-103162	chr20	30300674	30300675	31712871	31712872	6651	hg38	N/A	enh19573	fant58367	Enhatls110296	enhancer	E1266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038122	0.29288		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-20001	chr10	50109559	50109560	48901514	48901515	6652	hg38	N/A	N/A	N/A	Enhatls21966	enhancer	E1267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081675	0.29288		WDFY4	chr10	48684872	48982956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2436
enhrx-74406	chr17	72756980	72756981	74760841	74760842	6653	hg38	N/A	enh17370	N/A	Enhatls79874	enhancer	E1268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21763	0.29288		NHERF1	chr17	74748627	74769353	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7675
enhrx-60966	chr16	5815248	5815249	5765247	5765248	6654	hg38	N/A	N/A	N/A	Enhatls65542	enhancer	E1269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16981	0.2931		RBFOX1	chr16	5239801	7713340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1261
enhrx-112718	chr3	14864563	14864564	14823056	14823057	6655	hg38	N/A	enh20373	N/A	Enhatls120614	enhancer	E1270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21244	0.29342		FGD5	chr3	14810852	14934571	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	847
enhrx-101710	chr20	1404610	1404611	1423966	1423967	6656	hg38	N/A	enh19437	fant57697	Enhatls108773	enhancer	E1271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23075	0.29342		NSFL1C	chr20	1442161	1466918	17829	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	138
enhrx-132071	chr5	53880761	53880762	54584931	54584932	6657	hg38	N/A	enh22218	N/A	Enhatls141153	enhancer	E1272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098961	0.29368		SNX18	chr5	54517758	54546586	31436	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1862
enhrx-162104	chr8	142086211	142086212	141076112	141076113	6658	hg38	N/A	enh25386	N/A	Enhatls173166	enhancer	E1273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13396	0.29368		DENND3	chr8	141117277	141195808	38675	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5895
enhrx-38993	chr12	55286103	55286104	54892319	54892320	6659	hg38	N/A	enh80202	N/A	Enhatls42181	enhancer	E1274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16631	0.29368		MUCL1	chr12	54839368	54858387	30055	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4303
enhrx-72788	chr17	50496868	50496869	52419508	52419509	6660	hg38	N/A	enh81228	N/A	Enhatls78143	enhancer	E1275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12251	0.29368		CA10	chr17	51630312	52160017	257349	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6057
enhrx-47295	chr13	99625146	99625147	98972892	98972893	6661	hg38	N/A	enh15444	N/A	Enhatls51075	enhancer	E1276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14124	0.29368		DOCK9	chr13	98793428	99086625	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2917
enhrx-33256	chr11	113902516	113902517	114031794	114031795	6662	hg38	N/A	N/A	N/A	Enhatls36088	enhancer	E1277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096582	0.29368		ZBTB16	chr11	114059040	114256765	26178	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7925
enhrx-78215	chr18	53119577	53119578	55452346	55452347	6663	hg38	N/A	enh62692	N/A	Enhatls83910	enhancer	E1278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0025283	0.29368		TCF4	chr18	55222184	55664787	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2233
enhrx-100054	chr2	223749942	223749943	222885224	222885225	6664	hg38	N/A	enh34306	N/A	Enhatls107045	enhancer	E1279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00049244	0.29426		ACSL3	chr2	222860941	222944639	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11980
enhrx-54337	chr15	35219669	35219670	34927468	34927469	6665	hg38	N/A	N/A	N/A	Enhatls58521	enhancer	E1280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041023	0.29426		AQR	chr15	34851781	34969742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1039
enhrx-160885	chr8	107461494	107461495	106449266	106449267	6666	hg38	N/A	N/A	N/A	Enhatls171839	enhancer	E1281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016063	0.29426		OXR1	chr8	106270189	106752694	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4676
enhrx-65571	chr16	73104558	73104559	73070659	73070660	6667	hg38	N/A	enh16771	fant50940	Enhatls70363	enhancer	E1282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23352	0.29432		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5866
enhrx-50573	chr14	65464425	65464426	64997707	64997708	6668	hg38	N/A	enh3283	N/A	Enhatls54548	enhancer	E1283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03032	0.29443		CHURC1-FNTB	chr14	64914492	65061361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2530
enhrx-50573	chr14	65464425	65464426	64997707	64997708	6669	hg38	N/A	enh3283	N/A	Enhatls54548	enhancer	E1283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03032	0.29443		FNTB	chr14	64986894	65062650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2530
enhrx-151278	chr7	83314474	83314475	83685158	83685159	6670	hg38	N/A	enh24299	N/A	Enhatls161728	enhancer	E1284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15739	0.29443		SEMA3E	chr7	83363237	83649139	32111	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4090
enhrx-49010	chr14	34174891	34174892	33705685	33705686	6671	hg38	N/A	enh3073	N/A	Enhatls52908	enhancer	E1285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13734	0.29469		NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	967
enhrx-161371	chr8	123921839	123921840	122909599	122909600	6672	hg38	N/A	enh61582	N/A	Enhatls172350	enhancer	E1286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.27705	0.29469		ZHX2	chr8	122781654	122974510	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5162
enhrx-59540	chr15	101057506	101057507	100517301	100517302	6673	hg38	N/A	enh62536	N/A	Enhatls64112	enhancer	E1287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1121	0.29495		CERS3	chr15	100400394	100544720	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6242
enhrx-123260	chr4	7519709	7519710	7517982	7517983	6674	hg38	N/A	N/A	N/A	Enhatls131901	enhancer	E1288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022032	0.2957		SORCS2	chr4	7192537	7742836	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	804
enhrx-4199	chr1	36673134	36673135	36207533	36207534	6675	hg38	N/A	enh11738	N/A	Enhatls4631	enhancer	E1289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071825	0.29584		THRAP3	chr1	36224431	36305357	12418	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4198
enhrx-138267	chr5	179512371	179512372	180085371	180085372	6676	hg38	N/A	enh49023	fant21079	Enhatls147817	enhancer	E1290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068625	0.29584		RNF130	chr5	179911650	180072101	13247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8058
enhrx-146782	chr6	161971494	161971495	161550462	161550463	6677	hg38	N/A	N/A	N/A	Enhatls156901	enhancer	E1291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094522	0.29584		PRKN	chr6	161347416	162727771	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8370
enhrx-149131	chr7	36087855	36087856	36048245	36048246	6678	hg38	N/A	enh40063	N/A	Enhatls159394	enhancer	E1292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045744	0.29612		EEPD1	chr7	36153253	36301538	101549	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1943
enhrx-175715	chrX	116657178	116657179	117523215	117523216	6679	hg38	N/A	enh89390	N/A	Enhatls187910	enhancer	E1293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073762	0.29612		KLHL13	chrX	117897812	118117340	372581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5432
enhrx-30779	chr11	68874039	68874040	69106571	69106572	6680	hg38	N/A	enh64487	fant39059	Enhatls33458	enhancer	E1294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0368	0.29622		TPCN2	chr11	69048931	69136316	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5448
enhrx-52414	chr14	95740156	95740157	95273819	95273820	6681	hg38	N/A	enh3412	N/A	Enhatls56524	enhancer	E1295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15257	0.29688		CLMN	chr14	95181939	95319908	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4371
enhrx-23680	chr10	108855081	108855082	107095323	107095324	6682	hg38	N/A	enh102914	N/A	Enhatls25989	enhancer	E1296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12852	0.29688		SORCS1	chr10	106573662	107164706	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6115
enhrx-118798	chr3	129382208	129382209	129663365	129663366	6683	hg38	N/A	enh7531	N/A	Enhatls127140	enhancer	E1297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15051	0.29688		TMCC1	chr3	129647791	129893711	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6927
enhrx-42835	chr12	116749349	116749350	116311544	116311545	6684	hg38	N/A	N/A	N/A	Enhatls46255	enhancer	E1298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099359	0.29688		MED13L	chr12	115958575	116277693	28458	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-37729	chr12	47237865	47237866	46844082	46844083	6685	hg38	N/A	N/A	N/A	Enhatls40858	enhancer	E1299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1838	0.29839		SLC38A4	chr12	46764760	46832408	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3039
enhrx-15250	chr1	211725191	211725192	211551849	211551850	6686	hg38	N/A	enh12633	N/A	Enhatls16774	enhancer	E1300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18765	0.29839		SLC30A1	chr1	211571567	211579161	17466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15249
enhrx-93694	chr2	106139398	106139399	105522941	105522942	6687	hg38	N/A	enh18781	N/A	Enhatls100340	enhancer	E1301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1313	0.29839		FHL2	chr2	105357711	105438513	68856	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5620
enhrx-24771	chr10	126952372	126952373	125263803	125263804	6688	hg38	N/A	enh79765	N/A	Enhatls27124	enhancer	E1302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023527	0.2984		CTBP2	chr10	124984316	125161061	99747	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7206
enhrx-118540	chr3	126569764	126569765	126850921	126850922	6689	hg38	N/A	enh65742	fant13380	Enhatls126846	enhancer	E1303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11183	0.29991		CHCHD6	chr3	126704239	126960420	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6669
enhrx-60416	chr16	2480479	2480480	2430478	2430479	6690	hg38	N/A	N/A	N/A	Enhatls64976	enhancer	E1304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090121	0.29991		CCNF	chr16	2429446	2458854	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	711
enhrx-160375	chr8	96205393	96205394	95193165	95193166	6691	hg38	N/A	enh10432	N/A	Enhatls171300	enhancer	E1305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10567	0.29991		PLEKHF2	chr8	95115641	95156698	25935	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4166
enhrx-2106	chr1	18862211	18862212	18535717	18535718	6692	hg38	N/A	enh60100	N/A	Enhatls2354	enhancer	E1306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082445	0.29991		KLHDC7A	chr1	18480929	18485974	46404	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2105
enhrx-169473	chr9	136739376	136739377	133874254	133874255	6693	hg38	N/A	enh26096	fant34051	Enhatls181402	enhancer	E1307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1467	0.30007		VAV2	chr9	133761893	133992604	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6740
enhrx-15966	chr1	225397008	225397009	225209306	225209307	6694	hg38	N/A	enh92159	N/A	Enhatls17525	enhancer	E1308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16585	0.30008		DNAH14	chr1	224896261	225399292	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15965
enhrx-165542	chr9	85025390	85025391	82410475	82410476	6695	hg38	N/A	enh42024	N/A	Enhatls177162	enhancer	E1309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032721	0.30008		SPATA31D1	chr9	81988771	81995253	406278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2809
enhrx-129401	chr4	166545005	166545006	165623853	165623854	6696	hg38	N/A	enh83425	N/A	Enhatls138324	enhancer	E1310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23182	0.30008		CPE	chr4	165361193	165498547	123167	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6945
enhrx-21923	chr10	90574036	90574037	88814279	88814280	6697	hg38	N/A	N/A	N/A	Enhatls24130	enhancer	E1311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05249	0.30089		LIPM	chr10	88802729	88820546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4358
enhrx-31179	chr11	73164005	73164006	73452960	73452961	6698	hg38	N/A	N/A	N/A	Enhatls33888	enhancer	E1312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1684	0.30089		FAM168A	chr11	73400486	73598189	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-17332	chr1	245050765	245050766	244887463	244887464	6699	hg38	N/A	enh12852	N/A	Enhatls18956	enhancer	E1313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12562	0.30102		HNRNPU	chr1	244850296	244864560	17604	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17331
enhrx-19130	chr10	29919225	29919226	29630296	29630297	6700	hg38	N/A	enh13094	N/A	Enhatls20909	enhancer	E1314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037977	0.30103		SVIL	chr10	29457337	29736959	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1565
enhrx-78935	chr18	76653758	76653759	78893758	78893759	6701	hg38	N/A	enh96821	fant55656	Enhatls84685	enhancer	E1315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051291	0.30139		SALL3	chr18	78979817	79002677	86052	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2953
enhrx-132070	chr5	53829873	53829874	54534043	54534044	6702	hg38	N/A	enh22215	N/A	Enhatls141152	enhancer	E1316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1956	0.30139		SNX18	chr5	54517758	54546586	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1861
enhrx-170760	chrX	10051317	10051318	10083277	10083278	6703	hg38	N/A	enh26149	N/A	Enhatls182725	enhancer	E1317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096097	0.30166		WWC3	chrX	10015253	10144474	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	477
enhrx-86471	chr19	50050256	50050257	49546999	49547000	6704	hg38	N/A	enh52907	N/A	Enhatls92675	enhancer	E1318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0079491	0.30166		RCN3	chr19	49528002	49546962	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7441
enhrx-77199	chr18	24155593	24155594	26575629	26575630	6705	hg38	N/A	enh58796	N/A	Enhatls82851	enhancer	E1319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097738	0.30166		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-66272	chr16	86878532	86878533	86844926	86844927	6706	hg38	N/A	enh96722	fant51356	Enhatls71151	enhancer	E1320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11796	0.30166		FOXL1	chr16	86576367	86583478	261347	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6567
enhrx-50577	chr14	65486794	65486795	65020076	65020077	6707	hg38	N/A	N/A	N/A	Enhatls54552	enhancer	E1321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017599	0.30166		CHURC1-FNTB	chr14	64914492	65061361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2534
enhrx-50577	chr14	65486794	65486795	65020076	65020077	6708	hg38	N/A	N/A	N/A	Enhatls54552	enhancer	E1321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017599	0.30166		FNTB	chr14	64986894	65062650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2534
enhrx-50577	chr14	65486794	65486795	65020076	65020077	6709	hg38	N/A	N/A	N/A	Enhatls54552	enhancer	E1321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017599	0.30166		MAX	chr14	65006173	65102695	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2534
enhrx-95956	chr2	156047045	156047046	155190533	155190534	6710	hg38	N/A	N/A	N/A	Enhatls102721	enhancer	E1322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065506	0.30168		KCNJ3	chr2	154697854	154858354	301670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7882
enhrx-3209	chr1	27626060	27626061	27299569	27299570	6711	hg38	N/A	enh11664	fant910	Enhatls3568	enhancer	E1323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07757	0.30243		WDTC1	chr1	27234631	27308636	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3208
enhrx-160677	chr8	102508826	102508827	101496598	101496599	6712	hg38	N/A	N/A	N/A	Enhatls171624	enhancer	E1324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15974	0.30345		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-91364	chr2	64501024	64501025	64273890	64273891	6713	hg38	N/A	enh18605	N/A	Enhatls97894	enhancer	E1325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12503	0.30345		PELI1	chr2	64092651	64144420	126352	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3290
enhrx-150008	chr7	55063888	55063889	54996195	54996196	6714	hg38	N/A	enh24212	N/A	Enhatls160350	enhancer	E1326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019875	0.30452		EGFR	chr7	55019016	55211628	19595	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2820
enhrx-138689	chr6	7146155	7146156	7145922	7145923	6715	hg38	N/A	enh8942	N/A	Enhatls148272	enhancer	E1327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10606	0.30453		RREB1	chr6	7107596	7251980	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	277
enhrx-37881	chr12	48675883	48675884	48282100	48282101	6716	hg38	N/A	N/A	N/A	Enhatls41017	enhancer	E1328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028641	0.30453		H1-7	chr12	48328979	48330279	44838	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3191
enhrx-135209	chr5	129735988	129735989	130400295	130400296	6717	hg38	N/A	enh59541	N/A	Enhatls144433	enhancer	E1329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010384	0.30463		CHSY3	chr5	129904464	130186634	211578	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5000
enhrx-159811	chr8	81720223	81720224	80807988	80807989	6718	hg38	N/A	enh25098	N/A	Enhatls170712	enhancer	E1330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11355	0.30463		ZNF704	chr8	80628450	80874781	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3602
enhrx-24041	chr10	116383814	116383815	114624055	114624056	6719	hg38	N/A	enh13539	N/A	Enhatls26394	enhancer	E1331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037487	0.30506		ABLIM1	chr10	114431111	114768061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6476
enhrx-17628	chr10	1016475	1016476	970535	970536	6720	hg38	N/A	enh12893	N/A	Enhatls19259	enhancer	E1332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14328	0.30552		GTPBP4	chr10	988433	1019932	12026	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	63
enhrx-21512	chr10	80814153	80814154	79054396	79054397	6721	hg38	N/A	enh13336	N/A	Enhatls23674	enhancer	E1333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10184	0.30552		ZMIZ1	chr10	79068965	79316519	14373	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-34788	chr12	716729	716730	607563	607564	6722	hg38	N/A	enh14436	N/A	Enhatls37748	enhancer	E1334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1345	0.30552		NINJ2	chr12	564295	663589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	98
enhrx-120305	chr3	156838523	156838524	157120734	157120735	6723	hg38	N/A	enh7655	N/A	Enhatls128724	enhancer	E1335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10474	0.30552		CCNL1	chr3	157146507	157160760	24332	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8434
enhrx-165840	chr9	91503123	91503124	88888208	88888209	6724	hg38	N/A	enh25708	N/A	Enhatls177475	enhancer	E1336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074619	0.3064		S1PR3	chr9	88991467	89005155	98668	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3107
enhrx-97926	chr2	190352201	190352202	189487475	189487476	6725	hg38	N/A	enh19083	N/A	Enhatls104780	enhancer	E1337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067359	0.3064		WDR75	chr2	189441473	189475552	3148	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-21514	chr10	80918396	80918397	79158639	79158640	6726	hg38	N/A	enh1379	N/A	Enhatls23678	enhancer	E1338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045392	0.30646		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-4276	chr1	37586546	37586547	37120945	37120946	6727	hg38	N/A	N/A	N/A	Enhatls4710	enhancer	E1339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065746	0.30646		GRIK3	chr1	36795526	37034515	40320	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4275
enhrx-24097	chr10	117641731	117641732	115882220	115882221	6728	hg38	N/A	N/A	N/A	Enhatls26452	enhancer	E1340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056718	0.30694		ATRNL1	chr10	115093364	115948999	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6532
enhrx-15695	chr1	220595778	220595779	220422436	220422437	6729	hg38	N/A	enh103214	N/A	Enhatls17236	enhancer	E1341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07704	0.30722		MARK1	chr1	220528135	220664461	104763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15694
enhrx-lit77	chr3	171619929	171619930	171902139	171902140	6730	hg38					enhancer	E1342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17072	0.30722							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-165542	chr9	85296954	85296955	82682039	82682040	6731	hg38	N/A	N/A	N/A	Enhatls177162	enhancer	E1343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050271	0.30795		RASEF	chr9	82979589	83063177	259418	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2809
enhrx-112010	chr3	4575584	4575585	4533900	4533901	6732	hg38	N/A	enh20291	fant10991	Enhatls119853	enhancer	E1344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10775	0.30855		ITPR1	chr3	4493344	4847506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	139
enhrx-143266	chr6	84977079	84977080	84267361	84267362	6733	hg38	N/A	N/A	N/A	Enhatls153133	enhancer	E1345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17602	0.3089		CEP162	chr6	84124240	84227643	33614	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4854
enhrx-72941	chr17	55995931	55995932	57918570	57918571	6734	hg38	N/A	enh4496	N/A	Enhatls78310	enhancer	E1346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10477	0.30966		CUEDC1	chr17	57861242	57955412	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6210
enhrx-103273	chr20	30933144	30933145	32345341	32345342	6735	hg38	N/A	enh6345	N/A	Enhatls110407	enhancer	E1347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010162	0.30977		KIF3B	chr20	32277650	32335011	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1701
enhrx-49017	chr14	34591445	34591446	34122239	34122240	6736	hg38	N/A	N/A	N/A	Enhatls52919	enhancer	E1348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12297	0.31074		EGLN3	chr14	33924226	34222877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	974
enhrx-57849	chr15	75198288	75198289	74905947	74905948	6737	hg38	N/A	N/A	N/A	Enhatls62240	enhancer	E1349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0018302	0.31102		FAM219B	chr15	74899991	74906883	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4551
enhrx-140508	chr6	34192531	34192532	34224754	34224755	6738	hg38	N/A	enh23164	N/A	Enhatls150210	enhancer	E1350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02453	0.31175		HMGA1	chr6	34236872	34246231	5195	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2096
enhrx-91044	chr2	57320357	57320358	57093222	57093223	6739	hg38	N/A	enh96895	N/A	Enhatls97553	enhancer	E1351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044523	0.31175		CCDC85A	chr2	56183989	56386172	705039	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2970
enhrx-84658	chr19	40048610	40048611	39557970	39557971	6740	hg38	N/A	enh5131	fant56975	Enhatls90743	enhancer	E1352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11901	0.31175		EID2	chr19	39538706	39540161	17779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5628
enhrx-140494	chr6	33963862	33963863	33996085	33996086	6741	hg38	N/A	enh55719	N/A	Enhatls150196	enhancer	E1353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21778	0.31177		GRM4	chr6	34018642	34155622	20785	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2082
enhrx-4990	chr1	44324124	44324125	43858452	43858453	6742	hg38	N/A	enh305	N/A	Enhatls5476	enhancer	E1354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22248	0.31184		ST3GAL3	chr1	43707526	43931165	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4989
enhrx-107122	chr21	38432825	38432826	37060525	37060526	6743	hg38	N/A	N/A	N/A	Enhatls114543	enhancer	E1355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12339	0.31245		PIGP	chr21	37062845	37073170	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1005
enhrx-47754	chr13	112666398	112666399	112012084	112012085	6744	hg38	N/A	N/A	N/A	Enhatls51577	enhancer	E1356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081473	0.31295		SOX1	chr13	112067148	112071706	11080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3376
enhrx-45715	chr13	42586454	42586455	42012318	42012319	6745	hg38	N/A	enh15246	N/A	Enhatls49337	enhancer	E1357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00095511	0.31295		DGKH	chr13	42040035	42242896	25777	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1337
enhrx-105043	chr20	48077683	48077684	49461146	49461147	6746	hg38	N/A	enh82273	N/A	Enhatls112317	enhancer	E1358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083856	0.31295		KCNB1	chr20	49298106	49484297	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3471
enhrx-72477	chr17	48053802	48053803	49976438	49976439	6747	hg38	N/A	enh44444	N/A	Enhatls77791	enhancer	E1359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1232	0.31295		DLX4	chr17	49969189	49974959	705	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5746
enhrx-75970	chr17	81099530	81099531	83151761	83151762	6748	hg38	N/A	enh32384	fant54324	Enhatls81526	enhancer	E1360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047283	0.31295		METRNL	chr17	83079608	83095122	56608	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9239
enhrx-127741	chr4	118057320	118057321	117136164	117136165	6749	hg38	N/A	enh36965	N/A	Enhatls136608	enhancer	E1361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091772	0.31338		TRAM1L1	chr4	117083553	117085576	46894	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5285
enhrx-96064	chr2	159830344	159830345	158973832	158973833	6750	hg38	N/A	enh58967	N/A	Enhatls102836	enhancer	E1362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14889	0.31338		TANC1	chr2	158968639	159232659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7990
enhrx-8267	chr1	100539314	100539315	100073758	100073759	6751	hg38	N/A	enh74329	N/A	Enhatls8951	enhancer	E1363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12965	0.31338		MFSD14A	chr1	100038094	100083377	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8266
enhrx-33492	chr11	117928676	117928677	118057961	118057962	6752	hg38	N/A	N/A	N/A	Enhatls36348	enhancer	E1364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061684	0.31364		SMIM35	chr11	118003633	118088299	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8161
enhrx-6228	chr1	59518054	59518055	59052382	59052383	6753	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	E1365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078534	0.31364		FGGY	chr1	59296637	59762730	239985	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6227
enhrx-120397	chr3	158763246	158763247	159045457	159045458	6754	hg38	N/A	enh97378	N/A	Enhatls128824	enhancer	E1366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075767	0.31414		IQCJ-SCHIP1	chr3	159069251	159897629	21766	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8526
enhrx-39960	chr12	67315138	67315139	66921358	66921359	6755	hg38	N/A	enh14795	N/A	Enhatls43200	enhancer	E1367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093973	0.31414		GRIP1	chr12	66347430	67069162	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5270
enhrx-33910	chr11	120783462	120783463	120912753	120912754	6756	hg38	N/A	enh14333	N/A	Enhatls36796	enhancer	E1368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.26226	0.3149		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8579
enhrx-171757	chrX	32932589	32932590	32914472	32914473	6757	hg38	N/A	N/A	N/A	Enhatls183788	enhancer	E1369	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078339	0.3149		DMD	chrX	31119218	33339609	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1474
enhrx-102720	chr20	19947692	19947693	19967048	19967049	6758	hg38	N/A	enh65459	N/A	Enhatls109836	enhancer	E1370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12681	0.31521		RIN2	chr20	19758257	20002457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1148
enhrx-85501	chr19	44939884	44939885	44435701	44435702	6759	hg38	N/A	enh96845	N/A	Enhatls91636	enhancer	E1371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076751	0.31521		ZNF229	chr19	44426250	44448578	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6471
enhrx-64995	chr16	68703366	68703367	68669463	68669464	6760	hg38	N/A	enh31892	N/A	Enhatls69756	enhancer	E1372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042335	0.31556		CDH3	chr16	68644992	68727468	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5290
enhrx-87678	chr19	56195472	56195473	55684106	55684107	6761	hg38	N/A	enh109843	N/A	Enhatls93915	enhancer	E1373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12428	0.31556		EPN1	chr19	55675225	55709858	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8648
enhrx-129867	chr4	183891117	183891118	182969964	182969965	6762	hg38	N/A	enh37468	N/A	Enhatls138821	enhancer	E1374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043254	0.31556		DCTD	chr4	182890090	182917936	49412	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7411
enhrx-88565	chr2	11638863	11638864	11498737	11498738	6763	hg38	N/A	enh18271	N/A	Enhatls94883	enhancer	E1375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056034	0.31556		GREB1	chr2	11482340	11642788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	491
enhrx-158107	chr8	37892226	37892227	38034708	38034709	6764	hg38	N/A	enh24927	N/A	Enhatls168920	enhancer	E1376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061012	0.31556		EIF4EBP1	chr8	38030533	38060365	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1898
enhrx-62394	chr16	24537679	24537680	24526358	24526359	6765	hg38	N/A	enh16608	N/A	Enhatls67027	enhancer	E1377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16294	0.31556		RBBP6	chr16	24537692	24572863	10513	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2689
enhrx-9815	chr1	145556135	145556136	145878943	145878944	6766	hg38	N/A	N/A	N/A	Enhatls10778	enhancer	E1378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18556	0.31556		ANKRD35	chr1	145866559	145885866	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9814
enhrx-5629	chr1	51983875	51983876	51518203	51518204	6767	hg38	N/A	N/A	N/A	Enhatls6155	enhancer	E1379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13937	0.31556		EPS15	chr1	51354262	51519328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5628
enhrx-15110	chr1	209699737	209699738	209526392	209526393	6768	hg38	N/A	enh27452	N/A	Enhatls16629	enhancer	E1380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10663	0.31556		CAMK1G	chr1	209583713	209613939	53504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15109
enhrx-16456	chr1	230894083	230894084	230758337	230758338	6769	hg38	N/A	N/A	N/A	Enhatls18044	enhancer	E1381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12106	0.31556		CAPN9	chr1	230747383	230802003	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16455
enhrx-17884	chr10	6207552	6207553	6165589	6165590	6770	hg38	N/A	N/A	N/A	Enhatls19541	enhancer	E1382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0019326	0.31556		PFKFB3	chr10	6144933	6254644	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	319
enhrx-102498	chr20	15477442	15477443	15496797	15496798	6771	hg38	N/A	enh82218	N/A	Enhatls109596	enhancer	E1383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037943	0.31571		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	926
enhrx-3364	chr1	28496757	28496758	28170246	28170247	6772	hg38	N/A	enh184	fant991	Enhatls3731	enhancer	E1384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020097	0.31571		PTAFR	chr1	28147165	28193936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3363
enhrx-151133	chr7	79816270	79816271	80186954	80186955	6773	hg38	N/A	enh24285	N/A	Enhatls161568	enhancer	E1385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22962	0.31571		GNAI1	chr7	79768049	80226181	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3945
enhrx-64322	chr16	57852710	57852711	57818806	57818807	6774	hg38	N/A	enh16700	N/A	Enhatls69044	enhancer	E1386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094299	0.31685		KIFC3	chr16	57758216	57863053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4617
enhrx-33006	chr11	110765073	110765074	110894349	110894350	6775	hg38	N/A	N/A	N/A	Enhatls35813	enhancer	E1387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094942	0.31685		ARHGAP20	chr11	110577041	110713189	167463	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7675
enhrx-8531	chr1	108078949	108078950	107536327	107536328	6776	hg38	N/A	enh12108	N/A	Enhatls9213	enhancer	E1388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13196	0.31807		VAV3	chr1	107571160	107965180	30568	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8530
enhrx-24244	chr10	119242970	119242971	117483459	117483460	6777	hg38	N/A	enh43424	N/A	Enhatls26600	enhancer	E1389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033374	0.31854		EMX2	chr10	117542444	117549546	58156	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6679
enhrx-15304	chr1	212321021	212321022	212147679	212147680	6778	hg38	N/A	enh27468	N/A	Enhatls16828	enhancer	E1390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19133	0.31854		DTL	chr1	212035552	212105013	40531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15303
enhrx-30643	chr11	67849341	67849342	68081874	68081875	6779	hg38	N/A	N/A	N/A	Enhatls33314	enhancer	E1391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068914	0.31854		CHKA	chr11	68052858	68121444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5312
enhrx-138319	chr5	180033008	180033009	180606008	180606009	6780	hg38	N/A	enh22882	N/A	Enhatls147874	enhancer	E1392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23127	0.31854		FLT4	chr5	180601505	180649624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8110
enhrx-169473	chr9	136757520	136757521	133892398	133892399	6781	hg38	N/A	enh26096	N/A	Enhatls181402	enhancer	E1393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13221	0.31854		VAV2	chr9	133761893	133992604	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6740
enhrx-114549	chr3	47485419	47485420	47443929	47443930	6782	hg38	N/A	N/A	N/A	Enhatls122583	enhancer	E1394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11578	0.31854		SCAP	chr3	47413680	47477126	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2678
enhrx-2622	chr1	22740865	22740866	22414372	22414373	6783	hg38	N/A	enh11600	fant716	Enhatls2911	enhancer	E1395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038387	0.31854		ZBTB40	chr1	22428837	22531157	14300	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2621
enhrx-135863	chr5	138482761	138482762	139147072	139147073	6784	hg38	N/A	enh22623	N/A	Enhatls145141	enhancer	E1396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13061	0.3199		SIL1	chr5	138946723	139198368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5654
enhrx-66187	chr16	85028619	85028620	84995013	84995014	6785	hg38	N/A	N/A	fant51233	Enhatls71047	enhancer	E1397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12857	0.32002		ZDHHC7	chr16	84974174	85011535	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6482
enhrx-18303	chr10	15093843	15093844	15051844	15051845	6786	hg38	N/A	N/A	N/A	Enhatls19994	enhancer	E1398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027597	0.32004		OLAH	chr10	15032226	15073853	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	738
enhrx-2622	chr1	22675069	22675070	22348576	22348577	6787	hg38	N/A	enh78976	N/A	Enhatls2911	enhancer	E1399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15993	0.32025		ZBTB40	chr1	22428837	22531157	77436	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2621
enhrx-9384	chr1	116495404	116495405	115952783	115952784	6788	hg38	N/A	enh67111	N/A	Enhatls10129	enhancer	E1400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.005378	0.32025		SLC22A15	chr1	115976512	116070054	21064	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9383
enhrx-37733	chr12	48046757	48046758	47652974	47652975	6789	hg38	N/A	enh2322	N/A	Enhatls40864	enhancer	E1401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030942	0.32106		RPAP3	chr12	47661248	47706030	2957	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3043
enhrx-120951	chr3	174845234	174845235	175127444	175127445	6790	hg38	N/A	enh82872	N/A	Enhatls129423	enhancer	E1402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25295	0.32107		NAALADL2	chr3	174440986	175810548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9080
enhrx-40864	chr12	91258320	91258321	90864543	90864544	6791	hg38	N/A	N/A	N/A	Enhatls44159	enhancer	E1403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18311	0.32346		CCER1	chr12	90952214	90955176	57907	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6174
enhrx-143956	chr6	105967876	105967877	105520001	105520002	6792	hg38	N/A	enh84342	N/A	Enhatls153832	enhancer	E1404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043162	0.32361		PREP	chr6	105273217	105454062	63909	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5544
enhrx-128992	chr4	154515549	154515550	153594397	153594398	6793	hg38	N/A	N/A	N/A	Enhatls137913	enhancer	E1405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080431	0.32361		TMEM131L	chr4	153466345	153636711	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6536
enhrx-176153	chrX	128567649	128567650	129433672	129433673	6794	hg38	N/A	enh93950	N/A	Enhatls188357	enhancer	E1406	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15324	0.32361		SMARCA1	chrX	129446504	129523500	10767	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5870
enhrx-85620	chr19	45549066	45549067	45045808	45045809	6795	hg38	N/A	enh5165	N/A	Enhatls91763	enhancer	E1407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17397	0.32526		CLASRP	chr19	45039044	45070956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6590
enhrx-93818	chr2	109211611	109211612	108595155	108595156	6796	hg38	N/A	enh18791	N/A	Enhatls100478	enhancer	E1408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089476	0.32526		LIMS1	chr2	108533670	108687246	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5744
enhrx-15093	chr1	208217240	208217241	208043895	208043896	6797	hg38	N/A	enh98601	N/A	Enhatls16608	enhancer	E1409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062327	0.32526		PLXNA2	chr1	208022241	208244384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15092
enhrx-135999	chr5	139877703	139877704	140498118	140498119	6798	hg38	N/A	N/A	N/A	Enhatls145288	enhancer	E1410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14098	0.32526		ANKHD1	chr5	140401813	140539856	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5790
enhrx-135999	chr5	139877703	139877704	140498118	140498119	6799	hg38	N/A	N/A	N/A	Enhatls145288	enhancer	E1410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14098	0.32526		ANKHD1-EIF4EBP3	chr5	140401907	140549569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5790
enhrx-30911	chr11	71017562	71017563	71306516	71306517	6800	hg38	N/A	enh14056	N/A	Enhatls33605	enhancer	E1411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17756	0.32578		SHANK2	chr11	70467853	71252577	51283	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5580
enhrx-96627	chr2	169659681	169659682	168803171	168803172	6801	hg38	N/A	N/A	N/A	Enhatls103435	enhancer	E1412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018191	0.32601		NOSTRIN	chr2	168786538	168865514	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8553
enhrx-40832	chr12	89557944	89557945	89164167	89164168	6802	hg38	N/A	enh2489	fant42506	Enhatls44126	enhancer	E1413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13784	0.32634		DUSP6	chr12	89347234	89352501	182961	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6142
enhrx-131122	chr5	31932180	31932181	31932074	31932075	6803	hg38	N/A	enh22097	N/A	Enhatls140150	enhancer	E1414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22282	0.32634		PDZD2	chr5	31639130	32110932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	913
enhrx-48896	chr14	31529661	31529662	31060455	31060456	6804	hg38	N/A	enh15550	N/A	Enhatls52788	enhancer	E1415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043632	0.32722		AP4S1	chr14	31025105	31130996	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	853
enhrx-2622	chr1	22531623	22531624	22205130	22205131	6805	hg38	N/A	enh87577	N/A	Enhatls2911	enhancer	E1416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11813	0.32722		WNT4	chr1	22117312	22143969	59124	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2621
enhrx-116480	chr3	72328537	72328538	72279386	72279387	6806	hg38	N/A	enh20693	N/A	Enhatls124657	enhancer	E1417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076992	0.32785		RYBP	chr3	72371824	72446621	91682	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4609
enhrx-91707	chr2	71147086	71147087	70919956	70919957	6807	hg38	N/A	N/A	N/A	Enhatls98269	enhancer	E1418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10197	0.32785		VAX2	chr2	70900575	70933446	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3633
enhrx-43009	chr12	119636937	119636938	119199132	119199133	6808	hg38	N/A	enh15040	N/A	Enhatls46443	enhancer	E1419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024351	0.32853		HSPB8	chr12	119178930	119224855	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8319
enhrx-137697	chr5	174083600	174083601	174656597	174656598	6809	hg38	N/A	N/A	N/A	Enhatls147175	enhancer	E1420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071608	0.32853		MSX2	chr5	174724581	174730896	46140	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-104417	chr20	42771353	42771354	44142713	44142714	6810	hg38	N/A	enh19646	N/A	Enhatls111667	enhancer	E1421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18459	0.32911		JPH2	chr20	44106589	44187188	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-168418	chr9	130764093	130764094	128001814	128001815	6811	hg38	N/A	enh26033	N/A	Enhatls180273	enhancer	E1422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039324	0.32911		EEIG1	chr9	127940581	127980989	18705	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5685
enhrx-33016	chr11	111205572	111205573	111334847	111334848	6812	hg38	N/A	enh50996	fant39865	Enhatls35821	enhancer	E1423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13791	0.32911		POU2AF1	chr11	111352254	111449981	17296	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7685
enhrx-64765	chr16	67438789	67438790	67404886	67404887	6813	hg38	N/A	enh16735	N/A	Enhatls69500	enhancer	E1424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11422	0.32911		ZDHHC1	chr16	67394151	67416477	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5060
enhrx-91084	chr2	59256474	59256475	59029339	59029340	6814	hg38	N/A	N/A	N/A	Enhatls97596	enhancer	E1425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11247	0.32911		FANCL	chr2	58159242	58241410	783656	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3010
enhrx-136497	chr5	148586065	148586066	149206502	149206503	6815	hg38	N/A	enh63480	N/A	Enhatls145819	enhancer	E1426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031519	0.32973		ABLIM3	chr5	149141482	149260542	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6288
enhrx-161916	chr8	134911791	134911792	133899548	133899549	6816	hg38	N/A	enh25358	fant31303	Enhatls172956	enhancer	E1427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014024	0.32973		ST3GAL1	chr8	133454847	133571925	327273	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5707
enhrx-38664	chr12	53319034	53319035	52925250	52925251	6817	hg38	N/A	enh14735	fant41798	Enhatls41833	enhancer	E1428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16835	0.32973		KRT8	chr12	52897186	52949882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3974
enhrx-32678	chr11	104135343	104135344	104264615	104264616	6818	hg38	N/A	N/A	N/A	Enhatls35469	enhancer	E1429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010108	0.32995		PDGFD	chr11	103907188	104164379	93945	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7347
enhrx-103836	chr20	34650877	34650878	36062955	36062956	6819	hg38	N/A	enh19608	N/A	Enhatls111044	enhancer	E1430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061096	0.32995		CNBD2	chr20	35954563	36030700	25259	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2264
enhrx-65686	chr16	75079076	75079077	75045178	75045179	6820	hg38	N/A	enh64975	N/A	Enhatls70485	enhancer	E1431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0012721	0.33039		ZNRF1	chr16	74999023	75110994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5981
enhrx-58741	chr15	85473376	85473377	84930145	84930146	6821	hg38	N/A	enh16385	N/A	Enhatls63254	enhancer	E1432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14748	0.33044		SLC28A1	chr15	84884653	84945798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5443
enhrx-17719	chr10	3240075	3240076	3197883	3197884	6822	hg38	N/A	enh27728	N/A	Enhatls19357	enhancer	E1433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01129	0.33044		PITRM1	chr10	3137727	3172841	24763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	154
enhrx-166955	chr9	110200843	110200844	107438562	107438563	6823	hg38	N/A	enh25853	N/A	Enhatls178694	enhancer	E1434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071992	0.33045		KLF4	chr9	107484851	107490482	42378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4222
enhrx-102570	chr20	17525982	17525983	17545337	17545338	6824	hg38	N/A	enh19502	N/A	Enhatls109668	enhancer	E1435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068596	0.331		BFSP1	chr20	17493904	17558960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	998
enhrx-123373	chr4	8797673	8797674	8795947	8795948	6825	hg38	N/A	N/A	N/A	Enhatls132034	enhancer	E1436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077411	0.33154		HMX1	chr4	8846075	8871839	48599	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	917
enhrx-151278	chr7	83326895	83326896	83697579	83697580	6826	hg38	N/A	enh24299	N/A	Enhatls161728	enhancer	E1437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0070824	0.33194		SEMA3E	chr7	83363237	83649139	32111	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4090
enhrx-108288	chr22	17810207	17810208	17329317	17329318	6827	hg38	N/A	enh6706	N/A	Enhatls115806	enhancer	E1438	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040207	0.3327		CECR2	chr22	17359948	17558151	15284	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	119
enhrx-34915	chr12	2270862	2270863	2161696	2161697	6828	hg38	N/A	enh29328	N/A	Enhatls37890	enhancer	E1439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16197	0.3334		CACNA1C	chr12	1970771	2697950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	225
enhrx-161625	chr8	127582931	127582932	126570686	126570687	6829	hg38	N/A	enh41548	N/A	Enhatls172621	enhancer	E1440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18307	0.3334		LRATD2	chr8	126552442	126558478	4988	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5416
enhrx-135466	chr5	133415320	133415321	134079629	134079630	6830	hg38	N/A	enh38416	N/A	Enhatls144715	enhancer	E1441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.114	0.33404		TCF7	chr5	134114680	134151865	27814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5257
enhrx-88732	chr2	16900781	16900782	16719514	16719515	6831	hg38	N/A	enh76205	N/A	Enhatls95067	enhancer	E1442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10346	0.33404		CYRIA	chr2	16549458	16666331	46991	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	658
enhrx-30003	chr11	65019135	65019136	65251664	65251665	6832	hg38	N/A	enh89622	N/A	Enhatls32588	enhancer	E1443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014649	0.33404		POLA2	chr11	65261912	65305589	9277	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4672
enhrx-161365	chr8	122157900	122157901	121145660	121145661	6833	hg38	N/A	enh25254	N/A	Enhatls172343	enhancer	E1444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014681	0.33443		SNTB1	chr8	120535744	120813273	331956	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-56647	chr15	62405330	62405331	62113131	62113132	6834	hg38	N/A	enh31435	fant48427	Enhatls60942	enhancer	E1445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15328	0.33443		C2CD4A	chr15	62066976	62070917	42095	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3349
enhrx-160675	chr8	102467465	102467466	101455237	101455238	6835	hg38	N/A	enh25180	fant30334	Enhatls171623	enhancer	E1446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056864	0.33462		GRHL2	chr8	101492438	101669726	37053	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-140814	chr6	36601921	36601922	36634144	36634145	6836	hg38	N/A	enh66199	N/A	Enhatls150532	enhancer	E1447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12932	0.33462		SRSF3	chr6	36594361	36605600	25929	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2402
enhrx-31035	chr11	72070264	72070265	72359220	72359221	6837	hg38	N/A	N/A	N/A	Enhatls33743	enhancer	E1448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012071	0.33462		CLPB	chr11	72285494	72434629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5704
enhrx-52446	chr14	96562379	96562380	96096042	96096043	6838	hg38	N/A	enh15907	fant47170	Enhatls56568	enhancer	E1449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042733	0.33462		C14orf132	chr14	96039361	96093971	1869	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4403
enhrx-74228	chr17	70147966	70147967	72151825	72151826	6839	hg38	N/A	enh32347	N/A	Enhatls79685	enhancer	E1450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042964	0.33462		SOX9	chr17	72121019	72126416	25336	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-14696	chr1	205270331	205270332	205301203	205301204	6840	hg38	N/A	N/A	N/A	Enhatls16183	enhancer	E1451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11569	0.33462		NUAK2	chr1	205302062	205321745	693	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14695
enhrx-18012	chr10	8247156	8247157	8205193	8205194	6841	hg38	N/A	enh12966	N/A	Enhatls19676	enhancer	E1452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14922	0.33475		GATA3	chr10	8045377	8075198	127525	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	447
enhrx-130157	chr4	187684329	187684330	186763175	186763176	6842	hg38	N/A	enh8348	N/A	Enhatls139142	enhancer	E1453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068242	0.33475		FAT1	chr4	186587793	186726722	32891	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7701
enhrx-106530	chr21	29803347	29803348	28431026	28431027	6843	hg38	N/A	enh34845	N/A	Enhatls113906	enhancer	E1454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061506	0.33475		N6AMT1	chr21	28872190	28885371	427063	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	413
enhrx-31437	chr11	75807801	75807802	76096757	76096758	6844	hg38	N/A	enh14097	N/A	Enhatls34169	enhancer	E1455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050821	0.33629		UVRAG	chr11	75815209	76144232	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6106
enhrx-95535	chr2	144500682	144500683	143743113	143743114	6845	hg38	N/A	enh53325	N/A	Enhatls102274	enhancer	E1456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20051	0.33629		ARHGAP15	chr2	143091361	143768352	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7461
enhrx-24769	chr10	126753430	126753431	125064861	125064862	6846	hg38	N/A	enh1583	N/A	Enhatls27121	enhancer	E1457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21182	0.33629		CTBP2	chr10	124984316	125161061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7204
enhrx-5056	chr1	44793769	44793770	44328097	44328098	6847	hg38	N/A	enh11821	N/A	Enhatls5545	enhancer	E1458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0038976	0.33629		ERI3	chr1	44221069	44355260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5055
enhrx-19846	chr10	48497489	48497490	47241871	47241872	6848	hg38	N/A	N/A	N/A	Enhatls21774	enhancer	E1459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011832	0.33629		GDF10	chr10	47300196	47313577	48521	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2281
enhrx-135665	chr5	135957596	135957597	136621907	136621908	6849	hg38	N/A	enh83982	N/A	Enhatls144936	enhancer	E1460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070239	0.33685		TRPC7	chr5	136212744	136365545	254916	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5456
enhrx-146134	chr6	152023305	152023306	151702170	151702171	6850	hg38	N/A	N/A	N/A	Enhatls156206	enhancer	E1461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14191	0.33722		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7722
enhrx-171522	chrX	24316554	24316555	24298437	24298438	6851	hg38	N/A	N/A	N/A	Enhatls183551	enhancer	E1462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14493	0.33722		SUPT20HL2	chrX	24308209	24314069	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1239
enhrx-37066	chr12	30959069	30959070	30806135	30806136	6852	hg38	N/A	enh108525	N/A	Enhatls40168	enhancer	E1463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066419	0.33722		CAPRIN2	chr12	30709552	30823302	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2376
enhrx-13807	chr1	196370174	196370175	196401044	196401045	6853	hg38	N/A	enh27385	N/A	Enhatls15231	enhancer	E1464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1691	0.33722		KCNT2	chr1	196225778	196609225	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13806
enhrx-2275	chr1	19753878	19753879	19427384	19427385	6854	hg38	N/A	enh99	N/A	Enhatls2533	enhancer	E1465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038441	0.33726		CAPZB	chr1	19338774	19485539	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2274
enhrx-153960	chr7	127644822	127644823	128004769	128004770	6855	hg38	N/A	enh24489	N/A	Enhatls164528	enhancer	E1466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21001	0.33726		SND1	chr7	127652193	128092593	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6772
enhrx-27576	chr11	28422027	28422028	28400480	28400481	6856	hg38	N/A	enh28699	N/A	Enhatls30026	enhancer	E1467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.003371	0.33796		METTL15	chr11	28108247	28333507	64812	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2245
enhrx-105808	chr20	61587094	61587095	62955742	62955743	6857	hg38	N/A	enh19812	N/A	Enhatls113168	enhancer	E1468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13103	0.33797		SLC17A9	chr20	62952706	62969585	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4236
enhrx-30780	chr11	69042272	69042273	69274805	69274806	6858	hg38	N/A	enh28849	fant39068	Enhatls33461	enhancer	E1469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.24545	0.33797		MYEOV	chr11	69294154	69297287	19094	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5449
enhrx-45291	chr13	33559269	33559270	32985131	32985132	6859	hg38	N/A	enh80459	N/A	Enhatls48874	enhancer	E1470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026845	0.33895		KL	chr13	33016422	33066143	29286	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	913
enhrx-116484	chr3	72870380	72870381	72821229	72821230	6860	hg38	N/A	enh7335	N/A	Enhatls124664	enhancer	E1471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074848	0.33938		SHQ1	chr3	72749276	72861914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4613
enhrx-110050	chr22	35848753	35848754	35452760	35452761	6861	hg38	N/A	enh20169	N/A	Enhatls117765	enhancer	E1472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033538	0.34047		MCM5	chr22	35400136	35425431	21167	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1881
enhrx-99583	chr2	217850514	217850515	216985791	216985792	6862	hg38	N/A	enh44995	N/A	Enhatls106542	enhancer	E1473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10561	0.34047		TNP1	chr2	216859457	216860064	125199	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11509
enhrx-101070	chr2	238683649	238683650	237775006	237775007	6863	hg38	N/A	N/A	N/A	Enhatls108114	enhancer	E1474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084331	0.34047		LRRFIP1	chr2	237627586	237781643	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12996
enhrx-154225	chr7	129633435	129633436	129993595	129993596	6864	hg38	N/A	N/A	N/A	Enhatls164801	enhancer	E1475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075381	0.34058		ZC3HC1	chr7	130018286	130051451	12762	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7037
enhrx-65083	chr16	69430724	69430725	69396821	69396822	6865	hg38	N/A	enh16750	N/A	Enhatls69850	enhancer	E1476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13577	0.34058		TERF2	chr16	69355566	69408571	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5378
enhrx-65083	chr16	69430724	69430725	69396821	69396822	6866	hg38	N/A	enh16750	N/A	Enhatls69850	enhancer	E1476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13577	0.34058		CYB5B	chr16	69398401	69466264	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5378
enhrx-102867	chr20	22433572	22433573	22452934	22452935	6867	hg38	N/A	enh88593	N/A	Enhatls109991	enhancer	E1477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086317	0.34058		FOXA2	chr20	22580997	22585455	125481	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1295
enhrx-113503	chr3	36891388	36891389	36849897	36849898	6868	hg38	N/A	N/A	N/A	Enhatls121445	enhancer	E1478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19322	0.34064		TRANK1	chr3	36826818	36945057	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1632
enhrx-105299	chr20	55404658	55404659	56829602	56829603	6869	hg38	N/A	enh6549	N/A	Enhatls112614	enhancer	E1479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090435	0.34064		TFAP2C	chr20	56629305	56639283	189392	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-127968	chr4	122743026	122743027	121821871	121821872	6870	hg38	N/A	N/A	N/A	Enhatls136841	enhancer	E1480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099758	0.34064		CCNA2	chr4	121816443	121823883	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5512
enhrx-88295	chr2	7610066	7610067	7469935	7469936	6871	hg38	N/A	enh107780	N/A	Enhatls94563	enhancer	E1481	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12788	0.34065		RNF144A	chr2	6917411	7068286	399969	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	221
enhrx-160675	chr8	102472184	102472185	101459956	101459957	6872	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E1482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12415	0.34115		GRHL2	chr8	101492438	101669726	25730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-16593	chr1	233004846	233004847	232869100	232869101	6873	hg38	N/A	enh27616	N/A	Enhatls18186	enhancer	E1483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11141	0.3422		MAP10	chr1	232805415	232809929	55871	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16592
enhrx-20385	chr10	61960569	61960570	60200811	60200812	6874	hg38	N/A	N/A	N/A	Enhatls22453	enhancer	E1484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14168	0.34297		ANK3	chr10	60026297	60733490	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2820
enhrx-37593	chr12	44189931	44189932	43796128	43796129	6875	hg38	N/A	N/A	N/A	Enhatls40708	enhancer	E1485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.28772	0.34298		TWF1	chr12	43793722	43806317	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2903
enhrx-149032	chr7	33872118	33872119	33832506	33832507	6876	hg38	N/A	enh46343	N/A	Enhatls159278	enhancer	E1486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20787	0.34335		BMPER	chr7	33904910	34156427	69808	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1844
enhrx-106651	chr21	31815697	31815698	30443379	30443380	6877	hg38	N/A	N/A	N/A	Enhatls114034	enhancer	E1487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16994	0.34335		KRTAP15-1	chr21	30440274	30440869	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	534
enhrx-106651	chr21	31815697	31815698	30443379	30443380	6878	hg38	N/A	N/A	N/A	Enhatls114034	enhancer	E1487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16994	0.34335		KRTAP19-1	chr21	30479705	30480367	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	534
enhrx-169724	chr9	139121591	139121592	136229745	136229746	6879	hg38	N/A	enh11040	N/A	Enhatls181651	enhancer	E1488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11346	0.34335		QSOX2	chr9	136206332	136245812	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6991
enhrx-60966	chr16	5765842	5765843	5715841	5715842	6880	hg38	N/A	N/A	N/A	Enhatls65542	enhancer	E1489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22083	0.34335		RBFOX1	chr16	5239801	7713340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1261
enhrx-64931	chr16	68125674	68125675	68091771	68091772	6881	hg38	N/A	enh4100	N/A	Enhatls69684	enhancer	E1490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13359	0.34335		NFATC3	chr16	68085343	68229259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5226
enhrx-59074	chr15	90380590	90380591	89837358	89837359	6882	hg38	N/A	N/A	N/A	Enhatls63615	enhancer	E1491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030243	0.34335		AP3S2	chr15	89830598	89894638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5776
enhrx-59074	chr15	90380590	90380591	89837358	89837359	6883	hg38	N/A	N/A	N/A	Enhatls63615	enhancer	E1491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030243	0.34335		ARPIN-AP3S2	chr15	89834307	89912882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5776
enhrx-33306	chr11	115369277	115369278	115498559	115498560	6884	hg38	N/A	enh92342	N/A	Enhatls36141	enhancer	E1492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10482	0.34336		CADM1	chr11	115169235	115504957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7975
enhrx-118290	chr3	124002313	124002314	124283466	124283467	6885	hg38	N/A	enh35844	N/A	Enhatls126569	enhancer	E1493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0075163	0.34336		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6419
enhrx-97808	chr2	187817005	187817006	186952278	186952279	6886	hg38	N/A	enh82031	N/A	Enhatls104659	enhancer	E1494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14625	0.34336		ZSWIM2	chr2	186827474	186849170	101238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9734
enhrx-50519	chr14	65078161	65078162	64611443	64611444	6887	hg38	N/A	enh15680	N/A	Enhatls54494	enhancer	E1495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086958	0.34336		PPP1R36	chr14	64549960	64589381	19527	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2476
enhrx-25990	chr11	3963878	3963879	3942648	3942649	6888	hg38	N/A	enh13713	N/A	Enhatls28352	enhancer	E1496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14714	0.34381		STIM1	chr11	3854526	4093210	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	659
enhrx-62321	chr16	23551802	23551803	23540481	23540482	6889	hg38	N/A	enh31736	N/A	Enhatls66954	enhancer	E1497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14883	0.34509		EARS2	chr16	23520753	23557731	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2616
enhrx-141590	chr6	44036577	44036578	44068840	44068841	6890	hg38	N/A	enh9138	N/A	Enhatls151369	enhancer	E1498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23484	0.34509		MRPL14	chr6	44113450	44127452	41666	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3178
enhrx-153497	chr7	114770073	114770074	115130019	115130020	6891	hg38	N/A	enh78288	N/A	Enhatls164023	enhancer	E1499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16958	0.34509		MDFIC	chr7	114922093	115019917	106400	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6309
enhrx-131866	chr5	43208977	43208978	43208875	43208876	6892	hg38	N/A	enh8436	N/A	Enhatls140947	enhancer	E1500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17351	0.34512		NIM1K	chr5	43192224	43280850	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1657
enhrx-49223	chr14	38119744	38119745	37650539	37650540	6893	hg38	N/A	enh3123	N/A	Enhatls53123	enhancer	E1501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0027202	0.34513		TTC6	chr14	37595628	37842717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-154602	chr7	135615571	135615572	135930823	135930824	6894	hg38	N/A	N/A	N/A	Enhatls165221	enhancer	E1503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029466	0.34527		MTPN	chr7	135926759	135977359	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7414
enhrx-62190	chr16	22309464	22309465	22298143	22298144	6895	hg38	N/A	N/A	N/A	Enhatls66815	enhancer	E1504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0060793	0.34581		POLR3E	chr16	22297374	22335101	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2485
enhrx-15106	chr1	208377027	208377028	208203682	208203683	6896	hg38	N/A	enh12613	N/A	Enhatls16625	enhancer	E1505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044381	0.3475		PLXNA2	chr1	208022241	208244384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15105
enhrx-145618	chr6	139645183	139645184	139324046	139324047	6897	hg38	N/A	enh9392	fant24369	Enhatls155651	enhancer	E1506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089486	0.3475		TXLNB	chr6	139240060	139291998	31659	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7206
enhrx-155378	chr7	147826335	147826336	148129243	148129244	6898	hg38	N/A	N/A	N/A	Enhatls166008	enhancer	E1507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086589	0.3475		CNTNAP2	chr7	146116001	148420998	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8190
enhrx-51462	chr14	77120427	77120428	76654084	76654085	6899	hg38	N/A	enh96535	N/A	Enhatls55501	enhancer	E1508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090903	0.34765		VASH1	chr14	76761467	76783015	105356	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3419
enhrx-65716	chr16	75339488	75339489	75305590	75305591	6900	hg38	N/A	enh16793	N/A	Enhatls70526	enhancer	E1509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031144	0.34765		CFDP1	chr16	75293709	75433503	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6011
enhrx-165896	chr9	92258683	92258684	89643768	89643769	6901	hg38	N/A	enh25717	N/A	Enhatls177535	enhancer	E1510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14171	0.34765		GADD45G	chr9	89605011	89606555	34209	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3163
enhrx-34688	chr11	134478325	134478326	134608431	134608432	6902	hg38	N/A	enh96255	N/A	Enhatls37638	enhancer	E1511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04296	0.34835		B3GAT1	chr11	134378505	134412242	194150	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9357
enhrx-9503	chr1	118301730	118301731	117759108	117759109	6903	hg38	N/A	enh110654	fant2934	Enhatls10271	enhancer	E1512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10227	0.34945		GDAP2	chr1	117863484	117929621	104248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9502
enhrx-160675	chr8	102486622	102486623	101474394	101474395	6904	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E1513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17882	0.34972		GRHL2	chr8	101492438	101669726	12792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-116328	chr3	66707260	66707261	66656836	66656837	6905	hg38	N/A	enh93172	N/A	Enhatls124489	enhancer	E1514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14254	0.34972		LRIG1	chr3	66378796	66501022	150220	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4457
enhrx-136918	chr5	153666911	153666912	154287351	154287352	6906	hg38	N/A	N/A	N/A	Enhatls146315	enhancer	E1515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21048	0.3502		GALNT10	chr5	154190729	154420984	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6709
enhrx-138926	chr6	12372765	12372766	12372533	12372534	6907	hg38	N/A	enh55637	N/A	Enhatls148525	enhancer	E1516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087131	0.3502		EDN1	chr6	12290360	12297194	74645	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	514
enhrx-56526	chr15	60515551	60515552	60223352	60223353	6908	hg38	N/A	enh96593	N/A	Enhatls60811	enhancer	E1517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11325	0.3502		ANXA2	chr15	60347133	60402883	121718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3228
enhrx-167284	chr9	114908290	114908291	112146010	112146011	6909	hg38	N/A	N/A	N/A	Enhatls179037	enhancer	E1518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062653	0.3502		SUSD1	chr9	112040782	112175297	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4551
enhrx-161490	chr8	124992300	124992301	123980060	123980061	6910	hg38	N/A	N/A	fant30786	Enhatls172481	enhancer	E1519	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19869	0.3502		FER1L6	chr8	123851986	124120061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5281
enhrx-171440	chrX	22153439	22153440	22135322	22135323	6911	hg38	N/A	enh26194	N/A	Enhatls183464	enhancer	E1520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1798	0.3502		PHEX	chrX	22032324	22251310	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1157
enhrx-93469	chr2	101752272	101752273	101135810	101135811	6912	hg38	N/A	enh92912	N/A	Enhatls100103	enhancer	E1521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11607	0.3513		TBC1D8	chr2	101007227	101151382	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5395
enhrx-166762	chr9	104845868	104845869	102083586	102083587	6913	hg38	N/A	N/A	N/A	Enhatls178493	enhancer	E1522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091395	0.35142		GRIN3A	chr9	101569351	101738647	316587	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4029
enhrx-139010	chr6	15426827	15426828	15426596	15426597	6914	hg38	N/A	enh38822	N/A	Enhatls148614	enhancer	E1523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084601	0.35142		JARID2	chr6	15246068	15522042	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	598
enhrx-114828	chr3	49009630	49009631	48972197	48972198	6915	hg38	N/A	N/A	N/A	Enhatls122870	enhancer	E1524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029754	0.35142		ARIH2	chr3	48918820	48986382	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2957
enhrx-129280	chr4	160270722	160270723	159349570	159349571	6916	hg38	N/A	N/A	N/A	Enhatls138204	enhancer	E1525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056074	0.35142		RAPGEF2	chr4	159103012	159360174	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6824
enhrx-127237	chr4	104856496	104856497	103935339	103935340	6917	hg38	N/A	enh97519	N/A	Enhatls136085	enhancer	E1526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087249	0.35175		TACR3	chr4	103586030	103719985	212304	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4781
enhrx-77133	chr18	21942909	21942910	24362945	24362946	6918	hg38	N/A	enh96791	N/A	Enhatls82779	enhancer	E1527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1016	0.35175		OSBPL1A	chr18	24162044	24397824	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1151
enhrx-8099	chr1	95479754	95479755	95014198	95014199	6919	hg38	N/A	enh26980	N/A	Enhatls8775	enhancer	E1528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089945	0.35368		ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8098
enhrx-137428	chr5	168646065	168646066	169219061	169219062	6920	hg38	N/A	enh110253	N/A	Enhatls146864	enhancer	E1529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09141	0.35368		SLIT3	chr5	168661739	169301139	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7219
enhrx-73991	chr17	66325053	66325054	68328912	68328913	6921	hg38	N/A	enh17330	N/A	Enhatls79424	enhancer	E1530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013169	0.35368		ARSG	chr17	68259181	68422731	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7260
enhrx-99332	chr2	212287967	212287968	211423242	211423243	6922	hg38	N/A	N/A	fant9953	Enhatls106267	enhancer	E1531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054549	0.35383		ERBB4	chr2	211375716	212538841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11258
enhrx-30663	chr11	68148005	68148006	68380537	68380538	6923	hg38	N/A	enh1858	fant39033	Enhatls33335	enhancer	E1532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073666	0.35417		LRP5	chr11	68312590	68449275	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5332
enhrx-64872	chr16	67933115	67933116	67899212	67899213	6924	hg38	N/A	enh31888	N/A	Enhatls69626	enhancer	E1533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11958	0.35417		PSKH1	chr16	67893253	67929676	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5167
enhrx-116479	chr3	72202172	72202173	72153021	72153022	6925	hg38	N/A	enh7329	N/A	Enhatls124655	enhancer	E1534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0099646	0.3548		RYBP	chr3	72371824	72446621	213778	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4608
enhrx-94981	chr2	131086457	131086458	130328884	130328885	6926	hg38	N/A	enh5855	N/A	Enhatls101700	enhancer	E1535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13305	0.3548		CCDC115	chr2	130337932	130342324	26	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6907
enhrx-92381	chr2	85743978	85743979	85516855	85516856	6927	hg38	N/A	enh18703	N/A	Enhatls98978	enhancer	E1536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08685	0.3548		MAT2A	chr2	85539167	85545281	19876	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-59281	chr15	91974713	91974714	91431483	91431484	6928	hg38	N/A	enh96628	N/A	Enhatls63831	enhancer	E1537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.088335	0.3548		SV2B	chr15	91099949	91302565	127718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5983
enhrx-128749	chr4	148662708	148662709	147741557	147741558	6929	hg38	N/A	enh21860	N/A	Enhatls137657	enhancer	E1538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12855	0.35624		ARHGAP10	chr4	147732087	148072776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6293
enhrx-60509	chr16	2885924	2885925	2835923	2835924	6930	hg38	N/A	enh16505	fant49729	Enhatls65075	enhancer	E1539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14361	0.35624		ZG16B	chr16	2830252	2839585	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	804
enhrx-57186	chr15	67224601	67224602	66932263	66932264	6931	hg38	N/A	enh16258	N/A	Enhatls61524	enhancer	E1540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21106	0.35638		SMAD3	chr15	67063762	67195173	121126	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3888
enhrx-22887	chr10	100371262	100371263	98611505	98611506	6932	hg38	N/A	N/A	N/A	Enhatls25139	enhancer	E1541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10376	0.35638		HPSE2	chr10	98457076	99235862	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5322
enhrx-66233	chr16	85752444	85752445	85718838	85718839	6933	hg38	N/A	enh16876	N/A	Enhatls71103	enhancer	E1542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12165	0.3567		C16orf74	chr16	85690169	85751129	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6528
enhrx-115979	chr3	58026015	58026016	58040288	58040289	6934	hg38	N/A	enh20647	N/A	Enhatls124086	enhancer	E1543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17661	0.35762		FLNB	chr3	58008399	58172251	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4108
enhrx-166269	chr9	98262341	98262342	95500059	95500060	6935	hg38	N/A	enh10846	fant32911	Enhatls177961	enhancer	E1544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089826	0.35762		PTCH1	chr9	95442979	95517057	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3536
enhrx-85231	chr19	42975965	42975966	42471813	42471814	6936	hg38	N/A	enh5162	N/A	Enhatls91364	enhancer	E1545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026882	0.35762		CXCL17	chr19	42428277	42442946	16828	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6201
enhrx-82839	chr19	18430749	18430750	18319939	18319940	6937	hg38	N/A	enh17973	fant56546	Enhatls88832	enhancer	E1546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.005773	0.35762		LSM4	chr19	18306235	18323112	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3809
enhrx-59393	chr15	96714329	96714330	96171100	96171101	6938	hg38	N/A	enh52162	N/A	Enhatls63957	enhancer	E1547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13885	0.35763		NR2F2	chr15	96325937	96340263	151252	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6095
enhrx-96066	chr2	159948147	159948148	159091635	159091636	6939	hg38	N/A	enh18932	N/A	Enhatls102838	enhancer	E1548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11661	0.35774		TANC1	chr2	158968639	159232659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7992
enhrx-30590	chr11	67288851	67288852	67521380	67521381	6940	hg38	N/A	N/A	N/A	Enhatls33229	enhancer	E1549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073568	0.35776		CABP2	chr11	67518911	67524517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5259
enhrx-141340	chr6	42678232	42678233	42710494	42710495	6941	hg38	N/A	enh46126	N/A	Enhatls151102	enhancer	E1550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10859	0.35955		PRPH2	chr6	42696597	42722597	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2928
enhrx-86230	chr19	49169242	49169243	48665985	48665986	6942	hg38	N/A	N/A	N/A	Enhatls92414	enhancer	E1551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.069152	0.35955		NTN5	chr19	48661406	48673081	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7200
enhrx-29417	chr11	61780153	61780154	62012681	62012682	6943	hg38	N/A	enh13965	N/A	Enhatls31966	enhancer	E1552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15083	0.35955		FTH1	chr11	61959717	61967634	41360	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4086
enhrx-104941	chr20	47408311	47408312	48791774	48791775	6944	hg38	N/A	enh34673	N/A	Enhatls112213	enhancer	E1553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12379	0.35955		PREX1	chr20	48624251	48827999	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3369
enhrx-112490	chr3	12486457	12486458	12444958	12444959	6945	hg38	N/A	enh20341	N/A	Enhatls120372	enhancer	E1554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087714	0.35955		PPARG	chr3	12287367	12434356	171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	619
enhrx-148226	chr7	17827059	17827060	17787435	17787436	6946	hg38	N/A	N/A	N/A	Enhatls158404	enhancer	E1555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048286	0.35955		SNX13	chr7	17790760	17940494	5	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1038
enhrx-72475	chr17	47964755	47964756	49887392	49887393	6947	hg38	N/A	enh17209	N/A	Enhatls77789	enhancer	E1556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12305	0.35955		TAC4	chr17	49838299	49848069	35292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5744
enhrx-117459	chr3	111810191	111810192	112091344	112091345	6948	hg38	N/A	enh35768	N/A	Enhatls125705	enhancer	E1557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12427	0.35955		C3orf52	chr3	112086334	112128749	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5588
enhrx-74550	chr17	73455719	73455720	75459638	75459639	6949	hg38	N/A	N/A	N/A	Enhatls80028	enhancer	E1558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085698	0.35955		TMEM94	chr17	75441158	75500452	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7819
enhrx-16610	chr1	233248851	233248852	233113105	233113106	6950	hg38	N/A	enh12789	N/A	Enhatls18204	enhancer	E1559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25268	0.35983		PCNX2	chr1	232983434	233295725	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16609
enhrx-151278	chr7	83361887	83361888	83732571	83732572	6951	hg38	N/A	N/A	N/A	Enhatls161728	enhancer	E1560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13424	0.35983		SEMA3E	chr7	83363237	83649139	57681	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4090
enhrx-164997	chr9	71115765	71115766	68500849	68500850	6952	hg38	N/A	enh25572	N/A	Enhatls176565	enhancer	E1561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10168	0.35997		PGM5	chr9	68356610	68531061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2264
enhrx-105170	chr20	50270751	50270752	51654212	51654213	6953	hg38	N/A	enh60943	N/A	Enhatls112477	enhancer	E1562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10695	0.35997		ATP9A	chr20	51596513	51768390	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3598
enhrx-107065	chr21	37719811	37719812	36347513	36347514	6954	hg38	N/A	N/A	N/A	Enhatls114485	enhancer	E1563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1212	0.35997		MORC3	chr21	36320196	36376632	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	948
enhrx-105299	chr20	55497756	55497757	56922700	56922701	6955	hg38	N/A	enh19789	N/A	Enhatls112614	enhancer	E1564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080037	0.36036		BMP7	chr20	57168752	57266641	243994	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-106531	chr21	30014278	30014279	28641956	28641957	6956	hg38	N/A	enh19872	N/A	Enhatls113908	enhancer	E1565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12138	0.36155		N6AMT1	chr21	28872190	28885371	229438	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	414
enhrx-157560	chr8	25452625	25452626	25595109	25595110	6957	hg38	N/A	N/A	N/A	Enhatls168327	enhancer	E1566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1762	0.3618		CDCA2	chr8	25459198	25507911	31319	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1351
enhrx-127738	chr4	116276814	116276815	115355658	115355659	6958	hg38	N/A	enh113674	N/A	Enhatls136605	enhancer	E1567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071631	0.3618		NDST4	chr4	114827762	115113876	240434	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5282
enhrx-166961	chr9	111034390	111034391	108272110	108272111	6959	hg38	N/A	enh25874	fant33165	Enhatls178703	enhancer	E1568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15009	0.3618		ACTL7B	chr9	108854587	108855986	582074	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-102880	chr20	23171095	23171096	23190458	23190459	6960	hg38	N/A	enh6324	N/A	Enhatls110003	enhancer	E1569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091169	0.36246		CD93	chr20	23079359	23086324	97249	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1308
enhrx-123995	chr4	35248789	35248790	35247167	35247168	6961	hg38	N/A	N/A	N/A	Enhatls132694	enhancer	E1570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081709	0.36352		ARAP2	chr4	36066003	36244514	815841	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1539
enhrx-129926	chr4	185209107	185209108	184287954	184287955	6962	hg38	N/A	enh8333	N/A	Enhatls138887	enhancer	E1571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031552	0.36352		ENPP6	chr4	184088705	184221230	63190	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7470
enhrx-116482	chr3	72789385	72789386	72740234	72740235	6963	hg38	N/A	enh82562	N/A	Enhatls124659	enhancer	E1572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1257	0.36396		SHQ1	chr3	72749276	72861914	6973	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-81613	chr19	11865686	11865687	11754871	11754872	6964	hg38	N/A	N/A	N/A	Enhatls87493	enhancer	E1573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15533	0.36478		ZNF441	chr19	11766999	11784078	5035	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2583
enhrx-91837	chr2	72595080	72595081	72367951	72367952	6965	hg38	N/A	enh18671	N/A	Enhatls98405	enhancer	E1574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027615	0.36503		EXOC6B	chr2	72175983	72826041	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3763
enhrx-129660	chr4	174173567	174173568	173252416	173252417	6966	hg38	N/A	enh8328	N/A	Enhatls138608	enhancer	E1575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029239	0.36503		GALNT7	chr4	173168810	173323967	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7204
enhrx-105097	chr20	49051452	49051453	50434915	50434916	6967	hg38	N/A	enh19720	fant59052	Enhatls112396	enhancer	E1576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077854	0.36515		PTPN1	chr20	50510320	50585241	75301	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3525
enhrx-34364	chr11	126239011	126239012	126369116	126369117	6968	hg38	N/A	enh14374	N/A	Enhatls37275	enhancer	E1577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060794	0.36522		ST3GAL4	chr11	126355659	126414638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9033
enhrx-20411	chr10	62749242	62749243	60989484	60989485	6969	hg38	N/A	enh13241	N/A	Enhatls22488	enhancer	E1578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11577	0.36522		RHOBTB1	chr10	60869437	61001440	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2846
enhrx-112490	chr3	12509463	12509464	12467964	12467965	6970	hg38	N/A	enh20341	N/A	Enhatls120372	enhancer	E1579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12439	0.36522		TSEN2	chr3	12484420	12539644	13080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	619
enhrx-65105	chr16	69753069	69753070	69719166	69719167	6971	hg38	N/A	enh86220	N/A	Enhatls69873	enhancer	E1580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18301	0.36524		NQO1	chr16	69706995	69726668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5400
enhrx-153260	chr7	107608037	107608038	107967592	107967593	6972	hg38	N/A	enh46450	N/A	Enhatls163779	enhancer	E1581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060994	0.36554		LAMB1	chr7	107923798	108003213	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6072
enhrx-45774	chr13	43480594	43480595	42906458	42906459	6973	hg38	N/A	N/A	N/A	Enhatls49400	enhancer	E1582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16103	0.36554		EPSTI1	chr13	42886387	42992241	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1396
enhrx-160049	chr8	89427871	89427872	88415642	88415643	6974	hg38	N/A	enh73382	N/A	Enhatls170958	enhancer	E1583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12384	0.36554		MMP16	chr8	88032010	88328025	85532	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3840
enhrx-104836	chr20	45775534	45775535	47146895	47146896	6975	hg38	N/A	enh90092	N/A	Enhatls112095	enhancer	E1584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039904	0.36622		EYA2	chr20	46894623	47188844	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3264
enhrx-7213	chr1	78703453	78703454	78237769	78237770	6976	hg38	N/A	enh79082	N/A	Enhatls7824	enhancer	E1585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2117	0.36622		PTGFR	chr1	78303883	78540701	65882	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7212
enhrx-66323	chr16	87840716	87840717	87807110	87807111	6977	hg38	N/A	enh4180	fant51384	Enhatls71216	enhancer	E1586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03689	0.36665		SLC7A5	chr16	87830022	87869507	22686	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6618
enhrx-128356	chr4	140004128	140004129	139082974	139082975	6978	hg38	N/A	enh8213	fant16906	Enhatls137251	enhancer	E1587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14474	0.36665		ELF2	chr4	139057219	139177218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5900
enhrx-48040	chr13	115085206	115085207	114319731	114319732	6979	hg38	N/A	enh64763	N/A	Enhatls51881	enhancer	E1588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11701	0.36665		CHAMP1	chr13	114314487	114327322	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3662
enhrx-146141	chr6	152358089	152358090	152036954	152036955	6980	hg38	N/A	N/A	N/A	Enhatls156212	enhancer	E1589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12387	0.36665		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7729
enhrx-48013	chr13	114813011	114813012	114047535	114047536	6981	hg38	N/A	enh15518	N/A	Enhatls51853	enhancer	E1590	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18191	0.36665		RASA3	chr13	113977782	114132623	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3635
enhrx-102718	chr20	19884029	19884030	19903385	19903386	6982	hg38	N/A	enh6312	N/A	Enhatls109832	enhancer	E1591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032317	0.36665		RIN2	chr20	19758257	20002457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1146
enhrx-50009	chr14	57858709	57858710	57391991	57391992	6983	hg38	N/A	N/A	N/A	Enhatls53964	enhancer	E1592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056171	0.36665		NAA30	chr14	57390543	57415906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1966
enhrx-105292	chr20	55181824	55181825	56606768	56606769	6984	hg38	N/A	enh19778	N/A	Enhatls112607	enhancer	E1593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13334	0.36665		TFAP2C	chr20	56629305	56639283	17667	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3720
enhrx-107321	chr21	41426542	41426543	40054615	40054616	6985	hg38	N/A	enh34951	N/A	Enhatls114768	enhancer	E1594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059617	0.36665		DSCAM	chr21	40010998	40847158	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1204
enhrx-128497	chr4	142970160	142970161	142049007	142049008	6986	hg38	N/A	N/A	N/A	Enhatls137400	enhancer	E1595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.114	0.36688		INPP4B	chr4	142023159	142847432	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6041
enhrx-139247	chr6	24313819	24313820	24313591	24313592	6987	hg38	N/A	enh38922	N/A	Enhatls148872	enhancer	E1596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080072	0.36691		DCDC2	chr6	24171754	24358059	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	835
enhrx-157776	chr8	28570622	28570623	28713105	28713106	6988	hg38	N/A	N/A	N/A	Enhatls168552	enhancer	E1597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18191	0.36759		EXTL3	chr8	28622731	28756561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1567
enhrx-41708	chr12	104561555	104561556	104167777	104167778	6989	hg38	N/A	enh14938	N/A	Enhatls45073	enhancer	E1598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18102	0.36759		NFYB	chr12	104117085	104138241	25688	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-18017	chr10	9261959	9261960	9219996	9219997	6990	hg38	N/A	N/A	N/A	Enhatls19682	enhancer	E1599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16933	0.36759		GATA3	chr10	8045377	8075198	1136316	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	452
enhrx-158373	chr8	40263663	40263664	40406144	40406145	6991	hg38	N/A	enh98104	N/A	Enhatls169206	enhancer	E1600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026892	0.36803		ZMAT4	chr8	40530589	40897833	121854	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-34550	chr11	130575917	130575918	130706022	130706023	6992	hg38	N/A	enh2113	N/A	Enhatls37485	enhancer	E1601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16365	0.36892		SNX19	chr11	130866249	130916479	153065	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9219
enhrx-lit78	chr13	112624320	112624321	111970006	111970007	6993	hg38					enhancer	E1602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14716	0.36892							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-41708	chr12	104576166	104576167	104182388	104182389	6994	hg38	N/A	enh14939	N/A	Enhatls45073	enhancer	E1603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098141	0.36892		TXNRD1	chr12	104215778	104350307	29542	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-166918	chr9	108941645	108941646	106179364	106179365	6995	hg38	N/A	enh98284	N/A	Enhatls178653	enhancer	E1604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026264	0.36973		TMEM38B	chr9	105694540	105776629	400656	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4185
enhrx-14295	chr1	202016339	202016340	202047211	202047212	6996	hg38	N/A	enh12533	N/A	Enhatls15738	enhancer	E1605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085844	0.36974		ELF3	chr1	202007944	202017183	21922	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14294
enhrx-50804	chr14	69480912	69480913	69014195	69014196	6997	hg38	N/A	enh15725	fant46509	Enhatls54794	enhancer	E1606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10319	0.36974		ACTN1	chr14	68874127	68979440	34572	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2761
enhrx-93715	chr2	106891100	106891101	106274644	106274645	6998	hg38	N/A	enh69814	N/A	Enhatls100371	enhancer	E1607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060314	0.36974		UXS1	chr2	106093310	106194301	73529	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5641
enhrx-109040	chr22	24610225	24610226	24214257	24214258	6999	hg38	N/A	enh20089	N/A	Enhatls116676	enhancer	E1608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22159	0.36974		GGT5	chr22	24219653	24245082	2570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	871
enhrx-117420	chr3	111500883	111500884	111782036	111782037	7000	hg38	N/A	enh20806	N/A	Enhatls125663	enhancer	E1609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12074	0.37117		PHLDB2	chr3	111732496	111976517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-117420	chr3	111500883	111500884	111782036	111782037	7001	hg38	N/A	enh20806	N/A	Enhatls125663	enhancer	E1609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12074	0.37117		PLCXD2	chr3	111674675	111846447	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-133087	chr5	73372066	73372067	74076241	74076242	7002	hg38	N/A	enh83766	N/A	Enhatls142204	enhancer	E1610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084276	0.3717		ARHGEF28	chr5	73626157	73941993	131648	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2878
enhrx-14585	chr1	204256419	204256420	204287291	204287292	7003	hg38	N/A	enh12577	N/A	Enhatls16058	enhancer	E1611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095638	0.3717		PLEKHA6	chr1	204218852	204377665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14584
enhrx-107046	chr21	37626584	37626585	36254286	36254287	7004	hg38	N/A	enh6647	N/A	Enhatls114466	enhancer	E1612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037874	0.3717		DOP1B	chr21	36156823	36294274	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	929
enhrx-20788	chr10	71121309	71121310	69361553	69361554	7005	hg38	N/A	enh28194	N/A	Enhatls22888	enhancer	E1613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14246	0.3717		HK1	chr10	69269983	69401884	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3223
enhrx-154674	chr7	137880083	137880084	138195337	138195338	7006	hg38	N/A	enh24562	N/A	Enhatls165298	enhancer	E1614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077882	0.3717		AKR1D1	chr7	138076431	138118305	74355	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-16667	chr1	234594306	234594307	234458560	234458561	7007	hg38	N/A	N/A	N/A	Enhatls18268	enhancer	E1615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018598	0.3717		TARBP1	chr1	234391312	234479179	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16666
enhrx-101709	chr20	1364821	1364822	1384177	1384178	7008	hg38	N/A	enh62938	N/A	Enhatls108772	enhancer	E1616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11963	0.3717		FKBP1A	chr20	1368977	1393164	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	137
enhrx-10785	chr1	154324045	154324046	154351569	154351570	7009	hg38	N/A	enh49982	N/A	Enhatls11991	enhancer	E1617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14599	0.3717		ATP8B2	chr1	154325524	154351304	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10784
enhrx-2136	chr1	19315472	19315473	18988978	18988979	7010	hg38	N/A	enh74160	N/A	Enhatls2387	enhancer	E1618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23521	0.3717		IFFO2	chr1	18904279	18956676	28916	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-112928	chr3	17982789	17982790	17941297	17941298	7011	hg38	N/A	N/A	N/A	Enhatls120836	enhancer	E1619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055929	0.37273		TBC1D5	chr3	17157161	17742652	194778	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1057
enhrx-121121	chr3	179992474	179992475	180274686	180274687	7012	hg38	N/A	enh82891	N/A	Enhatls129609	enhancer	E1620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0033221	0.37309		PEX5L	chr3	179794957	180037053	236265	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9250
enhrx-12814	chr1	175541122	175541123	175571986	175571987	7013	hg38	N/A	enh50060	N/A	Enhatls14161	enhancer	E1621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19107	0.37309		TNR	chr1	175315193	175743595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12813
enhrx-37640	chr12	45670152	45670153	45276369	45276370	7014	hg38	N/A	enh14664	N/A	Enhatls40756	enhancer	E1622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0034248	0.37332		ANO6	chr12	45216019	45440404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2950
enhrx-161941	chr8	136527907	136527908	135515664	135515665	7015	hg38	N/A	enh41622	N/A	Enhatls172989	enhancer	E1623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13863	0.37476		KHDRBS3	chr8	135457455	135647610	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5732
enhrx-134084	chr5	95145232	95145233	95809528	95809529	7016	hg38	N/A	enh8569	N/A	Enhatls143242	enhancer	E1624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095477	0.37548		RHOBTB3	chr5	95730871	95824383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3875
enhrx-134084	chr5	95145232	95145233	95809528	95809529	7017	hg38	N/A	enh8569	N/A	Enhatls143242	enhancer	E1624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095477	0.37548		GLRX	chr5	95751318	95822726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3875
enhrx-131992	chr5	51787438	51787439	52491604	52491605	7018	hg38	N/A	N/A	N/A	Enhatls141070	enhancer	E1625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082554	0.37548		ITGA1	chr5	52787915	52959209	235405	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1783
enhrx-131992	chr5	51787438	51787439	52491604	52491605	7019	hg38	N/A	N/A	N/A	Enhatls141070	enhancer	E1625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082554	0.37548		PELO	chr5	52787915	52804044	235405	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1783
enhrx-26921	chr11	16915390	16915391	16893843	16893844	7020	hg38	hs2096	enh13813	N/A	Enhatls29351	enhancer	E1626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076458	0.37548		PLEKHA7	chr11	16777296	17014415	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-138562	chr6	3139608	3139609	3139374	3139375	7021	hg38	N/A	enh55614	N/A	Enhatls148130	enhancer	E1627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073316	0.37548		BPHL	chr6	3118373	3153578	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	150
enhrx-135107	chr5	127534995	127534996	128199303	128199304	7022	hg38	N/A	enh8663	N/A	Enhatls144328	enhancer	E1628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12944	0.3756		SLC12A2	chr5	128083765	128189677	5197	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4898
enhrx-14585	chr1	204263646	204263647	204294518	204294519	7023	hg38	hs2279	enh12577	N/A	Enhatls16058	enhancer	E1629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084836	0.37638		PLEKHA6	chr1	204218852	204377665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14584
enhrx-119533	chr3	139635334	139635335	139916492	139916493	7024	hg38	N/A	enh97355	N/A	Enhatls127904	enhancer	E1630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18505	0.37638		CLSTN2	chr3	139935184	140577397	16632	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7662
enhrx-15593	chr1	218540659	218540660	218367317	218367318	7025	hg38	N/A	enh12670	N/A	Enhatls17131	enhancer	E1631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00076006	0.37638		TGFB2	chr1	218345335	218444619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15592
enhrx-134245	chr5	98393294	98393295	99057590	99057591	7026	hg38	N/A	N/A	N/A	Enhatls143413	enhancer	E1632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0051315	0.37638		CHD1	chr5	98853984	98929007	128265	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4036
enhrx-132410	chr5	60895841	60895842	61600014	61600015	7027	hg38	N/A	enh45861	N/A	Enhatls141504	enhancer	E1633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059389	0.37715		ZSWIM6	chr5	61332257	61546172	48207	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2201
enhrx-50594	chr14	65710633	65710634	65243915	65243916	7028	hg38	N/A	enh3288	N/A	Enhatls54572	enhancer	E1634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020366	0.37715		MAX	chr14	65006173	65102695	136777	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2551
enhrx-133941	chr5	93143807	93143808	93808101	93808102	7029	hg38	N/A	N/A	N/A	Enhatls143094	enhancer	E1635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085254	0.37715		ARB2A	chr5	93617724	94111676	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3732
enhrx-113430	chr3	33758472	33758473	33716980	33716981	7030	hg38	N/A	N/A	N/A	Enhatls121370	enhancer	E1636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19906	0.37715		CLASP2	chr3	33496244	33718356	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1559
enhrx-90394	chr2	43014749	43014750	42787609	42787610	7031	hg38	N/A	enh96886	N/A	Enhatls96838	enhancer	E1637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049216	0.37771		HAAO	chr2	42767088	42792583	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2320
enhrx-44012	chr12	130582793	130582794	130098248	130098249	7032	hg38	N/A	enh15103	N/A	Enhatls47523	enhancer	E1638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077893	0.37771		FZD10	chr12	130162458	130165740	59089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9322
enhrx-72830	chr17	53362737	53362738	55285376	55285377	7033	hg38	"hs2291,hs2945"	enh17226	N/A	Enhatls78184	enhancer	E1639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14544	0.37771		HLF	chr17	55264959	55325187	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6099
enhrx-1204	chr1	10784435	10784436	10724378	10724379	7034	hg38	N/A	enh11496	fant351	Enhatls1303	enhancer	E1640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08723	0.37771		CASZ1	chr1	10636603	10796650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1203
enhrx-113447	chr3	34114592	34114593	34073100	34073101	7035	hg38	N/A	enh87234	N/A	Enhatls121389	enhancer	E1641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061179	0.3781		PDCD6IP	chr3	33798570	33869707	200641	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1576
enhrx-154211	chr7	129280786	129280787	129640945	129640946	7036	hg38	N/A	N/A	N/A	Enhatls164782	enhancer	E1642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17638	0.3792		NRF1	chr7	129611719	129757082	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7023
enhrx-78460	chr18	59795585	59795586	62128352	62128353	7037	hg38	N/A	enh112564	N/A	Enhatls84179	enhancer	E1643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0054439	0.37931		PIGN	chr18	61905254	62187118	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2478
enhrx-10786	chr1	154381118	154381119	154408642	154408643	7038	hg38	N/A	enh12276	N/A	Enhatls11992	enhancer	E1644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10574	0.38154		IL6R	chr1	154405192	154469450	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10785
enhrx-31696	chr11	78317917	78317918	78606872	78606873	7039	hg38	N/A	N/A	N/A	Enhatls34445	enhancer	E1645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076776	0.38207		NARS2	chr11	78435967	78574874	24254	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6365
enhrx-140961	chr6	38229610	38229611	38261834	38261835	7040	hg38	N/A	enh38974	N/A	Enhatls150697	enhancer	E1646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17578	0.3825		BTBD9	chr6	38168450	38640148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2549
enhrx-144416	chr6	114005932	114005933	113684730	113684731	7041	hg38	N/A	enh23539	fant23798	Enhatls154346	enhancer	E1647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082529	0.38336		MARCKS	chr6	113857344	113863475	172531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6004
enhrx-31732	chr11	79128513	79128514	79417469	79417470	7042	hg38	N/A	enh28911	N/A	Enhatls34480	enhancer	E1648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0011174	0.38336		TENM4	chr11	78652828	79441030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6401
enhrx-89996	chr2	36660672	36660673	36433529	36433530	7043	hg38	N/A	enh62775	N/A	Enhatls96402	enhancer	E1649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10798	0.38339		CRIM1	chr2	36355777	36551135	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1922
enhrx-103930	chr20	35475614	35475615	36847211	36847212	7044	hg38	N/A	enh6389	fant58527	Enhatls111156	enhancer	E1650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17464	0.38339		MTCL2	chr20	36777446	36863538	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2358
enhrx-158006	chr8	35235030	35235031	35377512	35377513	7045	hg38	N/A	enh40904	N/A	Enhatls168812	enhancer	E1651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10742	0.38339		UNC5D	chr8	35235474	35796550	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1797
enhrx-72717	chr17	48981873	48981874	50904512	50904513	7046	hg38	N/A	enh4464	fant53000	Enhatls78067	enhancer	E1652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041385	0.38349		TOB1	chr17	50862222	50867978	36202	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5986
enhrx-15402	chr1	214362364	214362365	214189021	214189022	7047	hg38	N/A	enh115388	N/A	Enhatls16929	enhancer	E1653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10679	0.38477		SMYD2	chr1	214281158	214337131	91425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15401
enhrx-69893	chr17	29399447	29399448	31072429	31072430	7048	hg38	N/A	enh17094	N/A	Enhatls75030	enhancer	E1654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20193	0.38554		NF1	chr17	31094926	31377687	17408	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3162
enhrx-18248	chr10	13858706	13858707	13816706	13816707	7049	hg38	N/A	enh27822	N/A	Enhatls19937	enhancer	E1655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032724	0.38554		FRMD4A	chr10	13643705	14462142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	683
enhrx-37686	chr12	46573603	46573604	46179820	46179821	7050	hg38	N/A	enh86935	N/A	Enhatls40803	enhancer	E1656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026181	0.38554		SLC38A1	chr12	46183062	46269951	1091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2996
enhrx-42762	chr12	114057241	114057242	113619436	113619437	7051	hg38	N/A	N/A	N/A	Enhatls46183	enhancer	E1657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15279	0.38555		LHX5	chr12	113462032	113471871	142480	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8072
enhrx-120328	chr3	157212546	157212547	157494757	157494758	7052	hg38	N/A	N/A	N/A	Enhatls128748	enhancer	E1658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17636	0.38555		VEPH1	chr3	157259741	157533619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8457
enhrx-126911	chr4	99539200	99539201	98618049	98618050	7053	hg38	N/A	enh48852	N/A	Enhatls135749	enhancer	E1659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0672	0.38555		TSPAN5	chr4	98470366	98658611	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4455
enhrx-68210	chr17	9161687	9161688	9258370	9258371	7054	hg38	N/A	enh48002	N/A	Enhatls73210	enhancer	E1660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062036	0.38686		STX8	chr17	9250470	9576591	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1479
enhrx-58291	chr15	79674128	79674129	79381786	79381787	7055	hg38	N/A	N/A	N/A	Enhatls62717	enhancer	E1661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043946	0.38708		TMED3	chr15	79311111	79427432	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4993
enhrx-130333	chr5	919723	919724	919608	919609	7056	hg38	N/A	N/A	fant17745	Enhatls139318	enhancer	E1662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094211	0.38727		TRIP13	chr5	892883	918120	1384	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	124
enhrx-85743	chr19	46081033	46081034	45577775	45577776	7057	hg38	N/A	enh18106	N/A	Enhatls91891	enhancer	E1663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10982	0.38727		OPA3	chr19	45527766	45602212	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6713
enhrx-89520	chr2	28051336	28051337	27828469	27828470	7058	hg38	N/A	N/A	N/A	Enhatls95875	enhancer	E1664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049585	0.38727		RBKS	chr2	27781378	27890387	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1446
enhrx-150008	chr7	55035269	55035270	54967576	54967577	7059	hg38	N/A	enh24210	fant26576	Enhatls160350	enhancer	E1665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16129	0.38727		EGFR	chr7	55019016	55211628	51264	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2820
enhrx-47614	chr13	110766923	110766924	110114576	110114577	7060	hg38	N/A	enh43968	N/A	Enhatls51417	enhancer	E1666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048739	0.38798		COL4A1	chr13	110148962	110307157	30595	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3236
enhrx-149039	chr7	34065386	34065387	34025774	34025775	7061	hg38	N/A	enh78176	N/A	Enhatls159285	enhancer	E1667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014327	0.38798		BMPER	chr7	33904910	34156427	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1851
enhrx-34788	chr12	694844	694845	585678	585679	7062	hg38	N/A	enh2131	N/A	Enhatls37748	enhancer	E1668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089043	0.38798		NINJ2	chr12	564295	663589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	98
enhrx-171952	chrX	39003143	39003144	39143890	39143891	7063	hg38	N/A	enh61680	N/A	Enhatls183990	enhancer	E1669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13936	0.38798		MID1IP1	chrX	38801439	38806537	335652	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1669
enhrx-16730	chr1	235533299	235533300	235369984	235369985	7064	hg38	N/A	N/A	N/A	Enhatls18333	enhancer	E1670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066231	0.38798		TBCE	chr1	235367359	235452443	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16729
enhrx-146139	chr6	152235848	152235849	151914713	151914714	7065	hg38	N/A	enh23793	N/A	Enhatls156210	enhancer	E1671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091746	0.38798		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7727
enhrx-59434	chr15	99155221	99155222	98611992	98611993	7066	hg38	N/A	enh89783	N/A	Enhatls64000	enhancer	E1672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12512	0.38798		IGF1R	chr15	98648538	98964530	36529	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6136
enhrx-8774	chr1	109914056	109914057	109371434	109371435	7067	hg38	N/A	enh12125	N/A	Enhatls9476	enhancer	E1673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17337	0.38819		SORT1	chr1	109309567	109397918	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8773
enhrx-148643	chr7	26740775	26740776	26701156	26701157	7068	hg38	N/A	enh84578	N/A	Enhatls158861	enhancer	E1674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063164	0.38819		SKAP2	chr7	26667067	26995239	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1455
enhrx-161057	chr8	112126615	112126616	111114386	111114387	7069	hg38	N/A	enh98187	N/A	Enhatls172013	enhancer	E1675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094653	0.38954		CSMD3	chr8	112222927	113436939	1106442	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4848
enhrx-21638	chr10	82685015	82685016	80925259	80925260	7070	hg38	N/A	enh67557	N/A	Enhatls23820	enhancer	E1676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012618	0.38954		SH2D4B	chr10	80537901	80646560	275856	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-8078	chr1	95249261	95249262	94783705	94783706	7071	hg38	N/A	enh26977	N/A	Enhatls8752	enhancer	E1677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036595	0.39046		SLC44A3	chr1	94820341	94895246	33983	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8077
enhrx-11584	chr1	159886167	159886168	159916377	159916378	7072	hg38	N/A	enh61913	N/A	Enhatls12863	enhancer	E1678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0048042	0.39089		TAGLN2	chr1	159918106	159925507	1671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11583
enhrx-34339	chr11	126026896	126026897	126157001	126157002	7073	hg38	N/A	enh2087	N/A	Enhatls37246	enhancer	E1679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033431	0.39158		RPUSD4	chr11	126202095	126211692	42586	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-13707	chr1	191497568	191497569	191528438	191528439	7074	hg38	N/A	enh95946	N/A	Enhatls15129	enhancer	E1680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094536	0.39177		RGS18	chr1	192158461	192185815	627917	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13706
enhrx-115674	chr3	53600962	53600963	53566935	53566936	7075	hg38	N/A	N/A	N/A	Enhatls123759	enhancer	E1681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086274	0.39177		CACNA1D	chr3	53328962	53813733	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3803
enhrx-75396	chr17	78235357	78235358	80261558	80261559	7076	hg38	N/A	N/A	N/A	Enhatls80918	enhancer	E1682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11184	0.39178		RNF213	chr17	80260851	80398794	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8665
enhrx-18473	chr10	17430391	17430392	17388392	17388393	7077	hg38	N/A	enh50331	fant34961	Enhatls20174	enhancer	E1683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063514	0.39219		ST8SIA6	chr10	17315420	17454595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	908
enhrx-148212	chr7	16945065	16945066	16905441	16905442	7078	hg38	N/A	enh72665	N/A	Enhatls158385	enhancer	E1684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15262	0.39242		AGR3	chr7	16859411	16881987	21295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1024
enhrx-161618	chr8	126938444	126938445	125926200	125926201	7079	hg38	N/A	enh49434	N/A	Enhatls172612	enhancer	E1685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05905	0.39242		TRIB1	chr8	125430357	125438403	487570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5409
enhrx-73266	chr17	58248649	58248650	60171288	60171289	7080	hg38	N/A	N/A	N/A	Enhatls78647	enhancer	E1686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054111	0.39338		USP32	chr17	60177326	60422470	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6535
enhrx-15105	chr1	208287796	208287797	208114451	208114452	7081	hg38	N/A	N/A	N/A	Enhatls16624	enhancer	E1687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08309	0.39338		PLXNA2	chr1	208022241	208244384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15104
enhrx-9248	chr1	114884713	114884714	114342091	114342092	7082	hg38	N/A	enh43029	N/A	Enhatls9986	enhancer	E1688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14732	0.39378		TRIM33	chr1	114392789	114511203	43731	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9247
enhrx-33899	chr11	120477138	120477139	120606429	120606430	7083	hg38	N/A	enh43635	N/A	Enhatls36784	enhancer	E1689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0046544	0.39378		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8568
enhrx-140538	chr6	34504589	34504590	34536812	34536813	7084	hg38	N/A	N/A	N/A	Enhatls150242	enhancer	E1690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012545	0.39378		PACSIN1	chr6	34466060	34535229	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2126
enhrx-31299	chr11	74154303	74154304	74443258	74443259	7085	hg38	N/A	enh28884	N/A	Enhatls34017	enhancer	E1691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19272	0.39378		KCNE3	chr11	74454840	74467729	3231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5968
enhrx-110629	chr22	39919052	39919053	39523047	39523048	7086	hg38	N/A	enh6864	N/A	Enhatls118396	enhancer	E1692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12387	0.39378		ATF4	chr22	39519694	39522683	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2460
enhrx-110629	chr22	39919052	39919053	39523047	39523048	7087	hg38	N/A	enh6864	N/A	Enhatls118396	enhancer	E1692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12387	0.39378		RPS19BP1	chr22	39529092	39532748	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2460
enhrx-9501	chr1	118105377	118105378	117562755	117562756	7088	hg38	N/A	enh12199	N/A	Enhatls10268	enhancer	E1693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058193	0.39378		MAN1A2	chr1	117367448	117528872	30372	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9500
enhrx-29458	chr11	62309735	62309736	62542263	62542264	7089	hg38	N/A	enh13975	N/A	Enhatls32013	enhancer	E1694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0051939	0.39378		AHNAK	chr11	62433541	62556235	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4127
enhrx-43848	chr12	124850439	124850440	124365893	124365894	7090	hg38	N/A	enh30029	N/A	Enhatls47329	enhancer	E1695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17663	0.39378		NCOR2	chr12	124324414	124567612	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9158
enhrx-76463	chr18	9757908	9757909	9757911	9757912	7091	hg38	N/A	enh17555	N/A	Enhatls82058	enhancer	E1696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15347	0.39378		RAB31	chr18	9708300	9862551	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	481
enhrx-85577	chr19	45362523	45362524	44859266	44859267	7092	hg38	N/A	enh18100	N/A	Enhatls91718	enhancer	E1697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088613	0.39378		NECTIN2	chr19	44846174	44889223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6547
enhrx-130158	chr4	188380482	188380483	187459328	187459329	7093	hg38	N/A	N/A	N/A	Enhatls139146	enhancer	E1698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0087335	0.39378		ZFP42	chr4	187995770	188005046	519240	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7702
enhrx-61737	chr16	19143032	19143033	19131710	19131711	7094	hg38	N/A	enh16588	N/A	Enhatls66348	enhancer	E1699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17116	0.39378		ITPRIPL2	chr16	19113963	19121629	5295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-6228	chr1	59537169	59537170	59071497	59071498	7095	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	E1700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.104	0.39378		FGGY	chr1	59296637	59762730	224464	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6227
enhrx-116678	chr3	85319800	85319801	85270650	85270651	7096	hg38	N/A	enh97296	N/A	Enhatls124863	enhancer	E1701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10373	0.39458		CADM2	chr3	84958988	86074429	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4807
enhrx-2883	chr1	24897042	24897043	24570551	24570552	7097	hg38	N/A	N/A	N/A	Enhatls3212	enhancer	E1702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.264	0.39458		NCMAP	chr1	24556086	24609328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2882
enhrx-126171	chr4	81630836	81630837	80709682	80709683	7098	hg38	N/A	enh108948	N/A	Enhatls134984	enhancer	E1703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17425	0.39458		CFAP299	chr4	80335729	80963750	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3715
enhrx-106268	chr21	15678646	15678647	14306325	14306326	7099	hg38	N/A	enh97167	N/A	Enhatls113621	enhancer	E1704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023963	0.39458		HSPA13	chr21	14371114	14383146	62321	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	151
enhrx-167274	chr9	114796093	114796094	112033813	112033814	7100	hg38	N/A	enh10892	N/A	Enhatls179022	enhancer	E1705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018451	0.39458		SUSD1	chr9	112040782	112175297	468	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4541
enhrx-120789	chr3	170571195	170571196	170853406	170853407	7101	hg38	N/A	enh113393	N/A	Enhatls129244	enhancer	E1706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18536	0.39458		RPL22L1	chr3	170864874	170870195	10309	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8918
enhrx-125100	chr4	57911313	57911314	57045147	57045148	7102	hg38	N/A	enh21546	N/A	Enhatls133846	enhancer	E1707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03598	0.39458		IGFBP7	chr4	57030772	57110385	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2644
enhrx-160677	chr8	102517952	102517953	101505724	101505725	7103	hg38	N/A	enh25182	N/A	Enhatls171624	enhancer	E1708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13777	0.39458		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4468
enhrx-5079	chr1	45186178	45186179	44720506	44720507	7104	hg38	N/A	enh312	N/A	Enhatls5570	enhancer	E1709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020831	0.39458		ARMH1	chr1	44674712	44725591	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5078
enhrx-109528	chr22	30195401	30195402	29799412	29799413	7105	hg38	N/A	N/A	N/A	Enhatls117205	enhancer	E1710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15055	0.39458		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-162035	chr8	140336786	140336787	139324542	139324543	7106	hg38	N/A	N/A	N/A	Enhatls173084	enhancer	E1711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11258	0.3946		KCNK9	chr8	139601096	139704109	262136	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5826
enhrx-77945	chr18	45684478	45684479	48158107	48158108	7107	hg38	N/A	enh17665	N/A	Enhatls83619	enhancer	E1712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22833	0.39582		ZBTB7C	chr18	48026671	48410752	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1963
enhrx-102866	chr20	22384736	22384737	22404098	22404099	7108	hg38	hs2547	enh82242	N/A	Enhatls109989	enhancer	E1713	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030483	0.39747		FOXA2	chr20	22580997	22585455	175836	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1294
enhrx-165737	chr9	88708792	88708793	86093877	86093878	7109	hg38	N/A	enh25661	N/A	Enhatls177364	enhancer	E1714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092013	0.39862		GOLM1	chr9	86026145	86100149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3004
enhrx-34137	chr11	124527158	124527159	124657262	124657263	7110	hg38	N/A	enh67968	N/A	Enhatls37043	enhancer	E1715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18712	0.39862		SIAE	chr11	124633112	124676303	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8806
enhrx-134982	chr5	125345534	125345535	126009841	126009842	7111	hg38	"hs2325,hs2325"	N/A	N/A	Enhatls144195	enhancer	E1716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19223	0.39862		GRAMD2B	chr5	126360131	126494371	349585	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4773
enhrx-17719	chr10	3468631	3468632	3426439	3426440	7112	hg38	N/A	enh12907	N/A	Enhatls19357	enhancer	E1717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18179	0.39862		PITRM1	chr10	3137727	3172841	251803	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	154
enhrx-133667	chr5	81642487	81642488	82346668	82346669	7113	hg38	N/A	N/A	N/A	Enhatls142796	enhancer	E1718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018311	0.39862		RPS23	chr5	82273319	82278396	60821	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3458
enhrx-10203	chr1	150879043	150879044	150906567	150906568	7114	hg38	N/A	enh12249	N/A	Enhatls11406	enhancer	E1719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025433	0.39862		CTXND2	chr1	150887135	150913292	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10202
enhrx-72923	chr17	55522529	55522530	57445168	57445169	7115	hg38	N/A	N/A	N/A	Enhatls78278	enhancer	E1720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077387	0.39862		MSI2	chr17	57255850	57684689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6192
enhrx-12855	chr1	176798480	176798481	176829344	176829345	7116	hg38	N/A	N/A	N/A	Enhatls14207	enhancer	E1721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069267	0.39862		PAPPA2	chr1	176463170	176845601	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12854
enhrx-167889	chr9	124644418	124644419	121882139	121882140	7117	hg38	N/A	enh42272	N/A	Enhatls179702	enhancer	E1722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058093	0.39885		TTLL11	chr9	121815673	122093606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-171566	chrX	24766751	24766752	24748634	24748635	7118	hg38	N/A	N/A	N/A	Enhatls183594	enhancer	E1723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11381	0.39885		POLA1	chrX	24693917	24996986	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1283
enhrx-37146	chr12	32163723	32163724	32010789	32010790	7119	hg38	N/A	N/A	N/A	Enhatls40254	enhancer	E1724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020119	0.39885		RESF1	chr12	31959407	31993107	14655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2456
enhrx-105220	chr20	52684350	52684351	54067811	54067812	7120	hg38	N/A	enh34700	N/A	Enhatls112537	enhancer	E1725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017774	0.39885		BCAS1	chr20	53936776	54070594	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3648
enhrx-169519	chr9	137220515	137220516	134328669	134328670	7121	hg38	N/A	enh26098	fant34078	Enhatls181431	enhancer	E1726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18009	0.39919		RXRA	chr9	134326454	134440585	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6786
enhrx-18011	chr10	8105474	8105475	8063511	8063512	7122	hg38	N/A	enh12958	N/A	Enhatls19673	enhancer	E1727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16155	0.39919		GATA3	chr10	8045377	8075198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	446
enhrx-2029	chr1	17641392	17641393	17314897	17314898	7123	hg38	N/A	enh42895	N/A	Enhatls2276	enhancer	E1728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095395	0.39919		PADI4	chr1	17308194	17364004	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-44512	chr13	20877943	20877944	20303804	20303805	7124	hg38	N/A	N/A	N/A	Enhatls48024	enhancer	E1729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023427	0.39919		GJB6	chr13	20221961	20232365	69455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	134
enhrx-57320	chr15	68984176	68984177	68691837	68691838	7125	hg38	N/A	enh96599	N/A	Enhatls61668	enhancer	E1730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029092	0.39919		CORO2B	chr15	68578992	68727806	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4022
enhrx-2903	chr1	25032138	25032139	24705647	24705648	7126	hg38	N/A	enh139	N/A	Enhatls3232	enhancer	E1731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0077198	0.39943		CLIC4	chr1	24745446	24844321	20859	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2902
enhrx-69882	chr17	29257771	29257772	30930753	30930754	7127	hg38	N/A	enh17091	N/A	Enhatls75016	enhancer	E1732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16845	0.39944		ADAP2	chr17	30921916	30959322	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3151
enhrx-161645	chr8	128844046	128844047	127831800	127831801	7128	hg38	N/A	enh10528	fant31004	Enhatls172652	enhancer	E1733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10359	0.39944		MYC	chr8	127735433	127742951	88722	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5436
enhrx-34364	chr11	126235499	126235500	126365604	126365605	7129	hg38	N/A	enh14374	N/A	Enhatls37275	enhancer	E1734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12228	0.4009		ST3GAL4	chr11	126355659	126414638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9033
enhrx-121946	chr3	192543675	192543676	192825886	192825887	7130	hg38	N/A	enh21231	N/A	Enhatls130504	enhancer	E1735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11071	0.40127		MB21D2	chr3	192796814	192917856	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10075
enhrx-159097	chr8	61532528	61532529	60619969	60619970	7131	hg38	N/A	N/A	N/A	Enhatls169949	enhancer	E1736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22524	0.40127		RAB2A	chr8	60516935	60623644	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2888
enhrx-24475	chr10	123754315	123754316	121994800	121994801	7132	hg38	N/A	enh13581	N/A	Enhatls26843	enhancer	E1737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013774	0.40228		TACC2	chr10	121989162	122254545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6910
enhrx-43253	chr12	121665282	121665283	121227479	121227480	7133	hg38	N/A	N/A	N/A	Enhatls46695	enhancer	E1738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048498	0.40231		P2RX4	chr12	121210064	121234106	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8563
enhrx-48993	chr14	32979025	32979026	32509819	32509820	7134	hg38	N/A	enh15558	fant45705	Enhatls52890	enhancer	E1739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12316	0.4027		AKAP6	chr14	32329297	32837684	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	950
enhrx-127826	chr4	119744737	119744738	118823582	118823583	7135	hg38	N/A	enh54951	N/A	Enhatls136696	enhancer	E1740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12632	0.40285		SEC24D	chr4	118722822	118836614	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5370
enhrx-30027	chr11	65138868	65138869	65371397	65371398	7136	hg38	N/A	enh28838	fant38906	Enhatls32616	enhancer	E1741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11801	0.40317		SLC25A45	chr11	65375191	65382674	3683	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4696
enhrx-133652	chr5	81096771	81096772	81800952	81800953	7137	hg38	N/A	enh108990	N/A	Enhatls142780	enhancer	E1742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091904	0.40334		SSBP2	chr5	81412803	81751250	47697	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3443
enhrx-166926	chr9	109655798	109655799	106893517	106893518	7138	hg38	N/A	enh25840	N/A	Enhatls178663	enhancer	E1743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091458	0.40345		ZNF462	chr9	106863165	107013634	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4193
enhrx-9084	chr1	113058156	113058157	112515534	112515535	7139	hg38	N/A	N/A	N/A	Enhatls9806	enhancer	E1744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086702	0.40345		WNT2B	chr1	112466540	112530165	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9083
enhrx-120833	chr3	171283662	171283663	171565872	171565873	7140	hg38	N/A	enh45565	fant14194	Enhatls129296	enhancer	E1745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024771	0.40346		PLD1	chr3	171600403	171810483	34399	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8962
enhrx-131316	chr5	35214381	35214382	35214279	35214280	7141	hg38	N/A	enh22128	N/A	Enhatls140361	enhancer	E1746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05163	0.40447		PRLR	chr5	35048755	35230487	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1107
enhrx-163975	chr9	33375026	33375027	33375028	33375029	7142	hg38	N/A	enh25536	N/A	Enhatls175088	enhancer	E1747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078595	0.40447		NFX1	chr9	33290515	33371157	1697	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1242
enhrx-50834	chr14	69824420	69824421	69357703	69357704	7143	hg38	N/A	N/A	fant46525	Enhatls54826	enhancer	E1748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17436	0.40508		GALNT16	chr14	69259963	69357033	588	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2791
enhrx-90579	chr2	45979875	45979876	45752736	45752737	7144	hg38	N/A	enh18509	N/A	Enhatls97038	enhancer	E1749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11093	0.40508		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2505
enhrx-109151	chr22	25387846	25387847	24991879	24991880	7145	hg38	N/A	enh6793	N/A	Enhatls116800	enhancer	E1750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062401	0.40508		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	982
enhrx-73032	chr17	56469031	56469032	58391670	58391671	7146	hg38	N/A	enh4499	fant53145	Enhatls78401	enhancer	E1751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026321	0.40508		RNF43	chr17	58353675	58417582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6301
enhrx-30782	chr11	69069288	69069289	69301821	69301822	7147	hg38	N/A	enh14032	fant39070	N/A	enhancer	E1752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15432	0.40508		MYEOV	chr11	69294154	69297287	4426	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5451
enhrx-144758	chr6	122816265	122816266	122495120	122495121	7148	hg38	N/A	enh106352	N/A	Enhatls154701	enhancer	E1753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054438	0.40508		PKIB	chr6	122471916	122726373	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6346
enhrx-112450	chr3	11595320	11595321	11553846	11553847	7149	hg38	N/A	enh7001	N/A	Enhatls120326	enhancer	E1754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083376	0.40508		ATG7	chr3	11272308	11557665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	579
enhrx-161651	chr8	129284834	129284835	128272588	128272589	7150	hg38	N/A	enh10541	N/A	Enhatls172665	enhancer	E1755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12298	0.40508		MYC	chr8	127735433	127742951	524850	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5442
enhrx-132227	chr5	55346889	55346890	56051062	56051063	7151	hg38	N/A	enh22238	N/A	Enhatls141310	enhancer	E1756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089381	0.40517		ANKRD55	chr5	56099679	56233330	36672	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2018
enhrx-95668	chr2	151022969	151022970	150166455	150166456	7152	hg38	N/A	enh33798	fant8915	Enhatls102420	enhancer	E1757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1244	0.40677		RND3	chr2	150468194	150539011	301652	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7594
enhrx-164040	chr9	33947040	33947041	33947042	33947043	7153	hg38	N/A	N/A	N/A	Enhatls175159	enhancer	E1758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052208	0.40745		UBAP2	chr9	33921692	34049388	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1307
enhrx-17719	chr10	3235282	3235283	3193090	3193091	7154	hg38	N/A	enh27728	N/A	Enhatls19357	enhancer	E1759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031166	0.40745		PITRM1	chr10	3137727	3172841	18004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	154
enhrx-65925	chr16	81311449	81311450	81277844	81277845	7155	hg38	N/A	enh16836	fant51086	Enhatls70766	enhancer	E1760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18429	0.40781		BCO1	chr16	81238688	81291142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6220
enhrx-165555	chr9	85781468	85781469	83166553	83166554	7156	hg38	N/A	enh57011	N/A	Enhatls177177	enhancer	E1761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025317	0.40849		FRMD3	chr9	83242989	83538546	73530	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2822
enhrx-2466	chr1	21578578	21578579	21252085	21252086	7157	hg38	N/A	enh11590	N/A	Enhatls2735	enhancer	E1762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094342	0.40853		ECE1	chr1	21217246	21345572	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2465
enhrx-158461	chr8	41832843	41832844	41975325	41975326	7158	hg38	N/A	N/A	N/A	Enhatls169293	enhancer	E1763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088648	0.40853		KAT6A	chr8	41929478	42051994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2252
enhrx-132391	chr5	60576848	60576849	61281021	61281022	7159	hg38	N/A	enh22273	N/A	Enhatls141489	enhancer	E1764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1348	0.40853		ZSWIM6	chr5	61332257	61546172	49250	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2182
enhrx-166943	chr9	110006275	110006276	107243994	107243995	7160	hg38	N/A	enh25845	N/A	Enhatls178680	enhancer	E1765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010432	0.40853		RAD23B	chr9	107283136	107332192	28543	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4210
enhrx-93391	chr2	100426938	100426939	99810476	99810477	7161	hg38	N/A	enh33510	N/A	Enhatls100021	enhancer	E1766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20913	0.40853		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5317
enhrx-21420	chr10	77872575	77872576	76112817	76112818	7162	hg38	N/A	enh28238	N/A	Enhatls23565	enhancer	E1767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078415	0.40853		LRMDA	chr10	75431623	76560168	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3855
enhrx-156053	chr7	156840097	156840098	157047403	157047404	7163	hg38	N/A	enh40714	N/A	Enhatls166718	enhancer	E1768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078758	0.40853		MNX1	chr7	156994050	157010663	34169	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8865
enhrx-135082	chr5	127059517	127059518	127723825	127723826	7164	hg38	N/A	N/A	N/A	Enhatls144302	enhancer	E1769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075853	0.40853		CCDC192	chr5	127703360	127941507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4873
enhrx-5345	chr1	46910382	46910383	46444710	46444711	7165	hg38	N/A	enh11835	N/A	Enhatls5857	enhancer	E1770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045133	0.40923		FAAH	chr1	46394316	46413845	29194	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5344
enhrx-17336	chr1	245203311	245203312	245040009	245040010	7166	hg38	N/A	enh67372	N/A	Enhatls18960	enhancer	E1771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050105	0.40923		EFCAB2	chr1	244969681	245121981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17335
enhrx-27419	chr11	22774804	22774805	22753258	22753259	7167	hg38	N/A	enh90881	N/A	Enhatls29867	enhancer	E1772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14116	0.40923		GAS2	chr11	22625641	22813001	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2088
enhrx-48832	chr14	30765425	30765426	30296219	30296220	7168	hg38	N/A	N/A	N/A	Enhatls52723	enhancer	E1773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13903	0.40923		PRKD1	chr14	29576478	30191898	102852	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	789
enhrx-39626	chr12	58233751	58233752	57839968	57839969	7169	hg38	N/A	enh14761	N/A	Enhatls42835	enhancer	E1774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031073	0.40923		CTDSP2	chr12	57819926	57846729	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4936
enhrx-129155	chr4	157621515	157621516	156700363	156700364	7170	hg38	N/A	N/A	N/A	Enhatls138079	enhancer	E1775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062813	0.40923		PDGFC	chr4	156760453	156971799	56981	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6699
enhrx-92029	chr2	74520072	74520073	74292945	74292946	7171	hg38	N/A	enh5650	N/A	Enhatls98604	enhancer	E1776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086965	0.4102		SLC4A5	chr2	74216241	74343416	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3955
enhrx-45290	chr13	33456123	33456124	32881985	32881986	7172	hg38	N/A	enh15210	N/A	Enhatls48871	enhancer	E1777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088915	0.4102		PDS5B	chr13	32586451	32778019	99484	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	912
enhrx-112120	chr3	8807560	8807561	8765874	8765875	7173	hg38	N/A	N/A	N/A	Enhatls119983	enhancer	E1778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09909	0.4102		OXTR	chr3	8750380	8769628	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	249
enhrx-161371	chr8	123798253	123798254	122786014	122786015	7174	hg38	N/A	enh10501	N/A	Enhatls172349	enhancer	E1779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078101	0.41037		ZHX2	chr8	122781654	122974510	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5162
enhrx-150278	chr7	65607467	65607468	66142480	66142481	7175	hg38	N/A	enh40214	N/A	Enhatls160634	enhancer	E1780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026643	0.41037		CRCP	chr7	66114825	66154568	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3090
enhrx-74207	chr17	68085936	68085937	70089795	70089796	7176	hg38	N/A	enh88308	N/A	Enhatls79654	enhancer	E1781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058519	0.41037		KCNJ16	chr17	70053428	70135608	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7476
enhrx-31770	chr11	82871723	82871724	83160681	83160682	7177	hg38	N/A	N/A	N/A	Enhatls34523	enhancer	E1782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083629	0.4109		PCF11	chr11	83156987	83187451	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6439
enhrx-129832	chr4	182609742	182609743	181688589	181688590	7178	hg38	N/A	enh37438	N/A	Enhatls138784	enhancer	E1783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053426	0.4109		TENM3	chr4	182144689	182803024	451928	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7376
enhrx-46203	chr13	51087493	51087494	50513357	50513358	7179	hg38	N/A	enh2877	N/A	Enhatls49879	enhancer	E1784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044995	0.41091		DLEU7	chr13	50711900	50843939	190977	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1825
enhrx-42832	chr12	116571122	116571123	116133317	116133318	7180	hg38	N/A	enh30006	N/A	Enhatls46252	enhancer	E1785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.069896	0.41138		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-66019	chr16	83749014	83749015	83715409	83715410	7181	hg38	N/A	enh31979	N/A	Enhatls70868	enhancer	E1786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056281	0.41154		CDH13	chr16	82626964	83800640	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6314
enhrx-100000	chr2	220959127	220959128	220094406	220094407	7182	hg38	N/A	N/A	N/A	Enhatls106992	enhancer	E1787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16817	0.41154		SLC4A3	chr2	219627393	219641980	450295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11926
enhrx-65999	chr16	82363586	82363587	82329981	82329982	7183	hg38	N/A	enh88262	N/A	Enhatls70846	enhancer	E1788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11199	0.41222		MPHOSPH6	chr16	82148161	82170224	156677	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6294
enhrx-13182	chr1	181012221	181012222	181043085	181043086	7184	hg38	N/A	enh47262	N/A	Enhatls14551	enhancer	E1789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078764	0.41222		MR1	chr1	181033373	181061938	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13181
enhrx-152684	chr7	101252281	101252282	101609001	101609002	7185	hg38	N/A	enh24377	N/A	Enhatls163174	enhancer	E1790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1545	0.41335		MYL10	chr7	101613329	101629296	2015	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5496
enhrx-663	chr1	3693243	3693244	3776679	3776680	7186	hg38	N/A	N/A	N/A	Enhatls699	enhancer	E1791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0015439	0.41335		LRRC47	chr1	3778558	3796498	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	662
enhrx-9925	chr1	147084390	147084391	147612591	147612592	7187	hg38	N/A	N/A	N/A	"Enhatls10996,Enhatls10997,Enhatls10998,Enhatls10999,Enhatls11000,Enhatls11001,Enhatls11002,Enhatls10656"	enhancer	E1792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0052987	0.41335		BCL9	chr1	147541500	147626216	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9924
enhrx-41818	chr12	106572639	106572640	106178861	106178862	7188	hg38	N/A	enh43810	N/A	Enhatls45190	enhancer	E1793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094934	0.41335		NUAK1	chr12	106063344	106138954	31113	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-167562	chr9	117219356	117219357	114457076	114457077	7189	hg38	N/A	N/A	N/A	Enhatls179331	enhancer	E1794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087328	0.41335		WHRN	chr9	114402079	114505473	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4829
enhrx-149992	chr7	53168897	53168898	53101204	53101205	7190	hg38	N/A	enh98016	N/A	Enhatls160329	enhancer	E1795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17192	0.41335		POM121L12	chr7	53035632	53036925	62208	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2804
enhrx-81415	chr19	11010010	11010011	10899334	10899335	7191	hg38	N/A	enh5003	N/A	Enhatls87289	enhancer	E1796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041421	0.41335		CARM1	chr19	10871552	10923075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2385
enhrx-135035	chr5	126211184	126211185	126875492	126875493	7192	hg38	N/A	enh22554	N/A	Enhatls144254	enhancer	E1797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010787	0.41335		MARCHF3	chr5	126867713	127030558	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4826
enhrx-122353	chr3	197099055	197099056	197372184	197372185	7193	hg38	N/A	enh21296	N/A	Enhatls130954	enhancer	E1798	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034989	0.41362		DLG1	chr3	197042559	197299330	62525	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10482
enhrx-153916	chr7	126577428	126577429	126937374	126937375	7194	hg38	N/A	enh89161	N/A	Enhatls164483	enhancer	E1799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025763	0.41487		GRM8	chr7	126438597	127252941	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6728
enhrx-46958	chr13	89601003	89601004	88948749	88948750	7195	hg38	N/A	N/A	N/A	Enhatls50705	enhancer	E1800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0071945	0.41487		SLITRK5	chr13	87671370	87696272	1085410	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2580
enhrx-146780	chr6	161825483	161825484	161404451	161404452	7196	hg38	N/A	N/A	N/A	Enhatls156899	enhancer	E1801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081582	0.41487		PRKN	chr6	161347416	162727771	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8368
enhrx-126053	chr4	79292027	79292028	78370873	78370874	7197	hg38	N/A	N/A	N/A	Enhatls134854	enhancer	E1802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078145	0.41487		FRAS1	chr4	78057322	78544269	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3597
enhrx-151777	chr7	93440752	93440753	93811440	93811441	7198	hg38	N/A	enh98043	N/A	Enhatls162245	enhancer	E1803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098167	0.41487		GNGT1	chr7	93591572	93911265	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4589
enhrx-42833	chr12	116695140	116695141	116257335	116257336	7199	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E1804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0225	0.41505		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-133354	chr5	77120322	77120323	77824498	77824499	7200	hg38	N/A	enh71811	N/A	Enhatls142474	enhancer	E1805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012515	0.41598		TBCA	chr5	77691165	77868780	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3145
enhrx-19583	chr10	43891654	43891655	43396206	43396207	7201	hg38	N/A	enh1187	N/A	Enhatls21374	enhancer	E1806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22258	0.41598		HNRNPF	chr10	43385616	43409186	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2018
enhrx-131255	chr5	34585890	34585891	34585785	34585786	7202	hg38	N/A	enh22114	fant18195	Enhatls140295	enhancer	E1807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029364	0.41598		RAI14	chr5	34656327	34832612	70463	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1046
enhrx-49220	chr14	38053086	38053087	37583881	37583882	7203	hg38	N/A	N/A	fant45826	Enhatls53121	enhancer	E1808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13907	0.41598		FOXA1	chr14	37589551	37595249	5338	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1177
enhrx-61154	chr16	11256872	11256873	11163015	11163016	7204	hg38	N/A	enh16532	N/A	Enhatls65739	enhancer	E1809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11709	0.41598		CLEC16A	chr16	10944538	11182186	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1449
enhrx-57453	chr15	71422208	71422209	71129869	71129870	7205	hg38	N/A	enh31485	N/A	Enhatls61814	enhancer	E1810	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14073	0.41598		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4155
enhrx-42833	chr12	116705945	116705946	116268140	116268141	7206	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E1811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11718	0.41598		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-159256	chr8	66938974	66938975	66026739	66026740	7207	hg38	N/A	enh25044	N/A	Enhatls170113	enhancer	E1812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058359	0.41711		DNAJC5B	chr8	66021552	66101245	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3047
enhrx-146132	chr6	151991494	151991495	151670359	151670360	7208	hg38	N/A	enh84451	N/A	Enhatls156204	enhancer	E1813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095925	0.41711		ESR1	chr6	151690495	152129619	19186	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-51799	chr14	88958775	88958776	88492431	88492432	7209	hg38	N/A	N/A	N/A	Enhatls55860	enhancer	E1814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15745	0.41711		PTPN21	chr14	88465777	88555007	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3756
enhrx-59073	chr15	90371354	90371355	89828122	89828123	7210	hg38	N/A	enh16406	N/A	Enhatls63614	enhancer	E1815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11071	0.41711		AP3S2	chr15	89830598	89894638	1929	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5775
enhrx-141263	chr6	42090645	42090646	42122907	42122908	7211	hg38	N/A	enh23246	fant22603	Enhatls151021	enhancer	E1816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085842	0.41711		C6orf132	chr6	42101118	42142620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2851
enhrx-122029	chr3	193884648	193884649	194166859	194166860	7212	hg38	N/A	enh21247	N/A	Enhatls130600	enhancer	E1817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12053	0.41711		HES1	chr3	194136147	194138732	26025	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10158
enhrx-135485	chr5	133589654	133589655	134253963	134253964	7213	hg38	N/A	enh22585	N/A	Enhatls144738	enhancer	E1818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0099851	0.41711		PPP2CA	chr5	134194034	134226073	23980	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5276
enhrx-27996	chr11	39618807	39618808	39597257	39597258	7214	hg38	N/A	N/A	N/A	Enhatls30467	enhancer	E1819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074774	0.41711		LRRC4C	chr11	40114202	41459773	492988	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2665
enhrx-33265	chr11	114186834	114186835	114316112	114316113	7215	hg38	N/A	enh67942	N/A	Enhatls36098	enhancer	E1820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068742	0.41733		NNMT	chr11	114257830	114313536	288	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7934
enhrx-42835	chr12	116737007	116737008	116299202	116299203	7216	hg38	N/A	enh51417	N/A	Enhatls46255	enhancer	E1822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19864	0.41773		MED13L	chr12	115958575	116277693	14048	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-121842	chr3	188991687	188991688	189273898	189273899	7217	hg38	N/A	enh36250	N/A	Enhatls130395	enhancer	E1823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090379	0.41787		TPRG1	chr3	188947213	189325304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9971
enhrx-94595	chr2	121867335	121867336	121109759	121109760	7218	hg38	N/A	N/A	N/A	Enhatls101293	enhancer	E1824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17387	0.4183		TFCP2L1	chr2	121216586	121285202	83758	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6521
enhrx-144414	chr6	112884816	112884817	112563614	112563615	7219	hg38	N/A	enh23523	N/A	Enhatls154343	enhancer	E1825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072029	0.41873		RFPL4B	chr6	112347329	112351294	207490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-45950	chr13	46709489	46709490	46135354	46135355	7220	hg38	N/A	N/A	fant44408	Enhatls49595	enhancer	E1826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030126	0.41943		LCP1	chr13	46125919	46211871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1572
enhrx-130157	chr4	188149728	188149729	187228574	187228575	7221	hg38	N/A	N/A	N/A	Enhatls139142	enhancer	E1827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16144	0.41947		FAT1	chr4	186587793	186726722	485780	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7701
enhrx-47779	chr13	113163750	113163751	112509436	112509437	7222	hg38	N/A	enh43972	N/A	Enhatls51603	enhancer	E1828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17017	0.41964		TUBGCP3	chr13	112485010	112588153	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3401
enhrx-34915	chr12	2269496	2269497	2160330	2160331	7223	hg38	N/A	enh29328	N/A	Enhatls37890	enhancer	E1829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092334	0.41964		CACNA1C	chr12	1970771	2697950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	225
enhrx-47564	chr13	108328630	108328631	107676282	107676283	7224	hg38	N/A	N/A	N/A	Enhatls51360	enhancer	E1830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11895	0.41991		NALF1	chr13	107163509	107867496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3186
enhrx-90347	chr2	42303652	42303653	42076512	42076513	7225	hg38	N/A	enh44769	N/A	Enhatls96786	enhancer	E1831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0069631	0.42201		PKDCC	chr2	42048020	42058517	11357	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2273
enhrx-121822	chr3	187635094	187635095	187917306	187917307	7226	hg38	N/A	enh7764	N/A	Enhatls130371	enhancer	E1832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078649	0.42201		BCL6-AS1	chr3	187743685	187746028	152090	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-90781	chr2	51240325	51240326	51013187	51013188	7227	hg38	N/A	enh60812	N/A	Enhatls97268	enhancer	E1833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25682	0.42225		NRXN1	chr2	49918502	51032561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2707
enhrx-90164	chr2	38323510	38323511	38096368	38096369	7228	hg38	N/A	enh18454	fant6627	Enhatls96586	enhancer	E1834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020337	0.423		CYP1B1	chr2	38067508	38109902	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2090
enhrx-88780	chr2	18527398	18527399	18346132	18346133	7229	hg38	N/A	enh18305	N/A	Enhatls95116	enhancer	E1835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054833	0.42384		RDH14	chr2	18554722	18560653	206568	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	706
enhrx-82204	chr19	15441958	15441959	15331147	15331148	7230	hg38	N/A	N/A	N/A	Enhatls88144	enhancer	E1836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.004345	0.42405		BRD4	chr19	15235518	15332545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3174
enhrx-82204	chr19	15441958	15441959	15331147	15331148	7231	hg38	N/A	N/A	N/A	Enhatls88144	enhancer	E1836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.004345	0.42405		AKAP8	chr19	15353384	15379787	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3174
enhrx-27944	chr11	35895330	35895331	35873780	35873781	7232	hg38	N/A	enh87865	N/A	Enhatls30412	enhancer	E1837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048002	0.42412		TRIM44	chr11	35662774	35818007	53869	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2613
enhrx-138594	chr6	4008727	4008728	4008493	4008494	7233	hg38	N/A	enh38746	N/A	Enhatls148165	enhancer	E1838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098167	0.42502		PRP4K	chr6	4021299	4064983	8319	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	182
enhrx-161686	chr8	131009160	131009161	129996914	129996915	7234	hg38	N/A	enh10552	N/A	Enhatls172706	enhancer	E1839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087864	0.42502		CYRIB	chr8	129839592	130017504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5477
enhrx-114940	chr3	49551490	49551491	49514057	49514058	7235	hg38	N/A	enh20588	N/A	Enhatls122981	enhancer	E1840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058394	0.42502		DAG1	chr3	49468712	49535618	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3069
enhrx-21456	chr10	79258229	79258230	77498471	77498472	7236	hg38	N/A	N/A	N/A	Enhatls23604	enhancer	E1841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058158	0.42508		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-135957	chr5	139521122	139521123	140141537	140141538	7237	hg38	N/A	enh22633	N/A	Enhatls145245	enhancer	E1842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033228	0.4257		IGIP	chr5	140125936	140129392	9129	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5748
enhrx-168058	chr9	127147046	127147047	124384767	124384768	7238	hg38	N/A	enh10985	N/A	Enhatls179878	enhancer	E1843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021391	0.42626		PSMB7	chr9	124353464	124415444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5325
enhrx-137143	chr5	158053517	158053518	158626509	158626510	7239	hg38	N/A	enh97786	N/A	Enhatls146554	enhancer	E1844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032478	0.42673		EBF1	chr5	158695919	159099916	67333	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6934
enhrx-50561	chr14	65405426	65405427	64938708	64938709	7240	hg38	N/A	N/A	N/A	Enhatls54537	enhancer	E1845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010611	0.42684		CHURC1	chr14	64914360	64944591	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2518
enhrx-50561	chr14	65405426	65405427	64938708	64938709	7241	hg38	N/A	N/A	N/A	Enhatls54537	enhancer	E1845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010611	0.42684		CHURC1-FNTB	chr14	64914492	65061361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2518
enhrx-110896	chr22	41920424	41920425	41524420	41524421	7242	hg38	N/A	N/A	N/A	Enhatls118664	enhancer	E1846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13603	0.42684		ACO2	chr22	41447829	41529273	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2727
enhrx-50872	chr14	70466147	70466148	69999430	69999431	7243	hg38	N/A	enh31001	fant46547	Enhatls54866	enhancer	E1847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046231	0.42684		SMOC1	chr14	69879415	70032366	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2829
enhrx-146359	chr6	155475755	155475756	155154621	155154622	7244	hg38	N/A	enh23801	N/A	Enhatls156439	enhancer	E1848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096851	0.42684		TIAM2	chr6	154832696	155257723	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7947
enhrx-144863	chr6	125905816	125905817	125584670	125584671	7245	hg38	hs2568	enh39430	N/A	Enhatls154809	enhancer	E1849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00038444	0.42684		HEY2	chr6	125747663	125761269	161334	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6451
enhrx-171960	chrX	39813346	39813347	39954092	39954093	7246	hg38	N/A	enh42558	N/A	Enhatls184001	enhancer	E1850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0084447	0.42684		BCOR	chrX	40049814	40177329	87274	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1677
enhrx-110759	chr22	41128869	41128870	40732865	40732866	7247	hg38	N/A	enh20217	fant61429	Enhatls118530	enhancer	E1851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039247	0.42684		SLC25A17	chr22	40769629	40819399	36580	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2590
enhrx-127956	chr4	122707044	122707045	121785889	121785890	7248	hg38	N/A	enh36990	N/A	Enhatls136829	enhancer	E1852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098931	0.42684		EXOSC9	chr4	121801319	121817021	7560	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5500
enhrx-10080	chr1	150230810	150230811	150258415	150258416	7249	hg38	N/A	enh74377	N/A	Enhatls11280	enhancer	E1853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025439	0.42684		CA14	chr1	150257250	150265078	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10079
enhrx-101053	chr2	238559386	238559387	237650743	237650744	7250	hg38	N/A	enh65421	N/A	Enhatls108091	enhancer	E1854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0080708	0.42684		LRRFIP1	chr2	237627586	237781643	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12979
enhrx-15250	chr1	211694978	211694979	211521636	211521637	7251	hg38	N/A	enh12631	N/A	Enhatls16774	enhancer	E1855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0040265	0.42684		RD3	chr1	211476521	211492162	23304	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15249
enhrx-10480	chr1	152410530	152410531	152438054	152438055	7252	hg38	N/A	enh61904	N/A	Enhatls11686	enhancer	E1856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14902	0.42684		CRNN	chr1	152409242	152414263	20312	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10479
enhrx-174041	chrX	77209293	77209294	77953796	77953797	7253	hg38	N/A	enh61710	N/A	Enhatls186210	enhancer	E1857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058249	0.42694		PGK1	chrX	77910738	78129295	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-174041	chrX	77209293	77209294	77953796	77953797	7254	hg38	N/A	enh61710	N/A	Enhatls186210	enhancer	E1857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058249	0.42694		ATP7A	chrX	77910689	78050395	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-41708	chr12	104574404	104574405	104180626	104180627	7255	hg38	N/A	enh14939	N/A	Enhatls45073	enhancer	E1858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061811	0.42694		TXNRD1	chr12	104215778	104350307	29542	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-114255	chr3	45688765	45688766	45647273	45647274	7256	hg38	N/A	enh20559	fant11866	Enhatls122262	enhancer	E1859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05385	0.42744		LIMD1	chr3	45594323	45686341	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2384
enhrx-169599	chr9	137823976	137823977	134932130	134932131	7257	hg38	N/A	enh11038	N/A	Enhatls181521	enhancer	E1860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036968	0.42837		FCN1	chr9	134903231	134917912	11543	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6866
enhrx-36157	chr12	14360988	14360989	14208054	14208055	7258	hg38	N/A	enh14552	N/A	Enhatls39211	enhancer	E1861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013999	0.42837		ATF7IP	chr12	14365681	14502931	142081	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1467
enhrx-138169	chr5	178720581	178720582	179293580	179293581	7259	hg38	N/A	enh94632	N/A	Enhatls147707	enhancer	E1862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1334	0.42931		ADAMTS2	chr5	179110852	179345461	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7960
enhrx-116478	chr3	71885395	71885396	71836244	71836245	7260	hg38	N/A	N/A	N/A	Enhatls124649	enhancer	E1863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15693	0.42931		PROK2	chr3	71771654	71785206	21805	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4607
enhrx-32444	chr11	100984424	100984425	101113693	101113694	7261	hg38	N/A	N/A	N/A	Enhatls35229	enhancer	E1864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13752	0.42931		PGR	chr11	101029623	101129813	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7113
enhrx-42833	chr12	116713681	116713682	116275876	116275877	7262	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E1865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049299	0.42998		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-36665	chr12	23388533	23388534	23235599	23235600	7263	hg38	N/A	enh103681	N/A	Enhatls39746	enhancer	E1866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10178	0.43059		SOX5	chr12	23529503	24562487	284463	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1975
enhrx-100181	chr2	227016052	227016053	226151336	226151337	7264	hg38	N/A	enh70191	fant10347	Enhatls107177	enhancer	E1867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22018	0.43164		NYAP2	chr2	225399709	225729887	421212	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12107
enhrx-31678	chr11	78127476	78127477	78416430	78416431	7265	hg38	N/A	enh1914	N/A	Enhatls34424	enhancer	E1868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15811	0.43164		GAB2	chr11	78215292	78418348	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6347
enhrx-158954	chr8	56901637	56901638	55989078	55989079	7266	hg38	N/A	enh10309	fant29586	Enhatls169798	enhancer	E1869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0581	0.43164		LYN	chr8	55879834	56014169	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2745
enhrx-47827	chr13	113607477	113607478	112953163	112953164	7267	hg38	N/A	enh92502	N/A	Enhatls51652	enhancer	E1870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11246	0.43178		MCF2L	chr13	112894377	113099742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3449
enhrx-75290	chr17	77803426	77803427	79829627	79829628	7268	hg38	N/A	enh4626	N/A	Enhatls80817	enhancer	E1871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036943	0.43178		CBX4	chr17	79833155	79839440	888	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8559
enhrx-77839	chr18	43853984	43853985	46274021	46274022	7269	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	E1872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081946	0.43178		ARK2N	chr18	46173552	46266992	5011	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1857
enhrx-41163	chr12	97553454	97553455	97159676	97159677	7270	hg38	N/A	N/A	N/A	Enhatls44492	enhancer	E1873	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062782	0.4318		NEDD1	chr12	96907223	96953780	199978	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6473
enhrx-88257	chr2	5882368	5882369	5742236	5742237	7271	hg38	N/A	N/A	N/A	Enhatls94514	enhancer	E1874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13096	0.4318		SOX11	chr2	5692383	5701385	37759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	183
enhrx-114547	chr3	47471577	47471578	47430087	47430088	7272	hg38	N/A	N/A	N/A	Enhatls122581	enhancer	E1875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061746	0.43221		SCAP	chr3	47413680	47477126	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2676
enhrx-116655	chr3	81926165	81926166	81877014	81877015	7273	hg38	N/A	N/A	N/A	Enhatls124839	enhancer	E1876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15756	0.43236		GBE1	chr3	81489702	81761645	77860	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4784
enhrx-40891	chr12	92937360	92937361	92543584	92543585	7274	hg38	N/A	enh14884	N/A	Enhatls44193	enhancer	E1877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15618	0.43237		PLEKHG7	chr12	92702842	92772455	158341	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6201
enhrx-59310	chr15	93363902	93363903	92820672	92820673	7275	hg38	N/A	enh3814	fant49391	Enhatls63861	enhancer	E1878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053288	0.43237		FAM174B	chr15	92617447	92809798	10391	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6012
enhrx-156037	chr7	156699084	156699085	156906390	156906391	7276	hg38	N/A	enh49349	N/A	Enhatls166705	enhancer	E1879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045312	0.43313		LMBR1	chr7	156677790	156893183	6913	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8849
enhrx-67995	chr17	7855386	7855387	7952068	7952069	7277	hg38	N/A	enh96727	N/A	Enhatls72979	enhancer	E1880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054682	0.4332		CNTROB	chr17	7932100	7949920	1999	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1264
enhrx-147963	chr7	7901031	7901032	7861400	7861401	7278	hg38	N/A	enh9590	N/A	Enhatls158120	enhancer	E1881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017244	0.43337		UMAD1	chr7	7640751	7968020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	775
enhrx-168015	chr9	126090171	126090172	123327892	123327893	7279	hg38	N/A	enh25981	N/A	Enhatls179828	enhancer	E1882	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091324	0.43337		CRB2	chr9	123356169	123378753	16122	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5282
enhrx-139236	chr6	23952675	23952676	23952447	23952448	7280	hg38	N/A	enh97834	N/A	Enhatls148861	enhancer	E1883	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13597	0.4334		NRSN1	chr6	24126185	24147530	171619	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	824
enhrx-91136	chr2	61188880	61188881	60961745	60961746	7281	hg38	N/A	N/A	N/A	Enhatls97649	enhancer	E1884	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12969	0.43419		PUS10	chr2	60940222	61018255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3062
enhrx-91933	chr2	73839880	73839881	73612753	73612754	7282	hg38	N/A	N/A	N/A	Enhatls98505	enhancer	E1885	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14693	0.4342		ALMS1	chr2	73385757	73609916	50	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3859
enhrx-149379	chr7	42333003	42333004	42293404	42293405	7283	hg38	N/A	enh24157	N/A	Enhatls159665	enhancer	E1886	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023158	0.4342		GLI3	chr7	41960948	42264100	26827	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2191
enhrx-153113	chr7	105857908	105857909	106217462	106217463	7284	hg38	N/A	enh40454	N/A	Enhatls163630	enhancer	E1887	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073543	0.4342		NAMPT	chr7	106248297	106285966	28958	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5925
enhrx-956	chr1	8319335	8319336	8259275	8259276	7285	hg38	N/A	enh11468	fant264	Enhatls1017	enhancer	E1888	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1829	0.43568		SLC45A1	chr1	8318113	8344167	58558	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-105888	chr20	61969269	61969270	63337917	63337918	7286	hg38	N/A	enh45182	N/A	Enhatls113244	enhancer	E1889	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10955	0.43622		COL20A1	chr20	63293185	63334851	997	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4316
enhrx-101247	chr2	241110126	241110127	240170709	240170710	7287	hg38	N/A	enh95583	N/A	Enhatls108295	enhancer	E1890	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0023387	0.43652		OTOS	chr2	240139025	240144562	23887	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13173
enhrx-123921	chr4	26374384	26374385	26372762	26372763	7288	hg38	N/A	enh63298	N/A	Enhatls132611	enhancer	E1891	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085228	0.43653		RBPJ	chr4	26163454	26435131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1465
enhrx-18140	chr10	12707985	12707986	12665986	12665987	7289	hg38	N/A	N/A	N/A	Enhatls19828	enhancer	E1892	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078116	0.43653		CAMK1D	chr10	12349546	12835545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	575
enhrx-79792	chr19	3336926	3336927	3336928	3336929	7290	hg38	N/A	enh17861	N/A	Enhatls85597	enhancer	E1893	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2231	0.43653		NFIC	chr19	3314402	3469217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	762
enhrx-36082	chr12	12729292	12729293	12576358	12576359	7291	hg38	N/A	enh80074	N/A	Enhatls39133	enhancer	E1894	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12658	0.43653		DUSP16	chr12	12473281	12562863	13029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1392
enhrx-57408	chr15	70489141	70489142	70196802	70196803	7292	hg38	N/A	enh3698	N/A	Enhatls61772	enhancer	E1895	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015364	0.43692		TLE3	chr15	70047789	70098176	80851	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-76195	chr18	3283650	3283651	3283652	3283653	7293	hg38	N/A	enh62659	N/A	Enhatls81760	enhancer	E1896	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060852	0.43782		MYL12B	chr18	3261478	3278461	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	213
enhrx-145333	chr6	135124021	135124022	134802883	134802884	7294	hg38	N/A	enh39533	N/A	Enhatls155328	enhancer	E1897	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068305	0.4379		ALDH8A1	chr6	134917392	134950115	112456	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6921
enhrx-135787	chr5	137690757	137690758	138355068	138355069	7295	hg38	N/A	N/A	N/A	Enhatls145063	enhancer	E1898	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10188	0.4379		KDM3B	chr5	138352684	138437027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5578
enhrx-75938	chr17	80816420	80816421	82858544	82858545	7296	hg38	N/A	enh17458	N/A	Enhatls81484	enhancer	E1899	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057109	0.43816		TBCD	chr17	82752041	82945914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9207
enhrx-77945	chr18	45753900	45753901	48227529	48227530	7297	hg38	N/A	enh17666	N/A	Enhatls83619	enhancer	E1900	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049302	0.43816		ZBTB7C	chr18	48026671	48410752	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1963
enhrx-68102	chr17	8227503	8227504	8324185	8324186	7298	hg38	N/A	N/A	N/A	Enhatls73098	enhancer	E1901	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071839	0.43816		ARHGEF15	chr17	8310240	8322514	9	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1371
enhrx-78770	chr18	69972685	69972686	72305450	72305451	7299	hg38	N/A	N/A	N/A	Enhatls84510	enhancer	E1902	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1254	0.43905		CBLN2	chr18	72536679	72638517	163039	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2788
enhrx-113296	chr3	32221895	32221896	32180403	32180404	7300	hg38	N/A	enh86461	N/A	Enhatls121226	enhancer	E1903	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019731	0.43905		GPD1L	chr3	32105688	32168709	4429	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1425
enhrx-119115	chr3	132927310	132927311	133208466	133208467	7301	hg38	N/A	enh7547	N/A	Enhatls127467	enhancer	E1904	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10846	0.44002		TMEM108	chr3	133038390	133397775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7244
enhrx-38224	chr12	50645880	50645881	50252097	50252098	7302	hg38	N/A	enh14703	N/A	Enhatls41383	enhancer	E1905	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17073	0.44002		LIMA1	chr12	50175787	50283520	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3534
enhrx-116243	chr3	64330597	64330598	64344921	64344922	7303	hg38	N/A	enh20663	fant12359	Enhatls124387	enhancer	E1906	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12289	0.44062		PRICKLE2	chr3	64092235	64445407	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4372
enhrx-37073	chr12	31175255	31175256	31022321	31022322	7304	hg38	N/A	enh43715	N/A	Enhatls40177	enhancer	E1907	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043199	0.44062		TSPAN11	chr12	30926427	30996602	25425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2383
enhrx-42835	chr12	116725927	116725928	116288122	116288123	7305	hg38	N/A	enh15023	N/A	Enhatls46255	enhancer	E1908	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062456	0.44062		MED13L	chr12	115958575	116277693	6728	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-171883	chrX	37684222	37684223	37824969	37824970	7306	hg38	N/A	enh11178	N/A	Enhatls183920	enhancer	E1909	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17437	0.44062		CYBB	chrX	37780058	37813461	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1600
enhrx-16681	chr1	234988213	234988214	234852466	234852467	7307	hg38	N/A	enh995	N/A	Enhatls18291	enhancer	E1910	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069667	0.44099		IRF2BP2	chr1	234604268	234610178	241720	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-128931	chr4	153629793	153629794	152708641	152708642	7308	hg38	N/A	enh21882	N/A	Enhatls137852	enhancer	E1911	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14686	0.44099		TMEM154	chr4	152618627	152679997	25997	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6475
enhrx-72742	chr17	49195906	49195907	51118545	51118546	7309	hg38	N/A	N/A	N/A	Enhatls78097	enhancer	E1912	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09317	0.44099		SPAG9	chr17	50962173	51120868	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6011
enhrx-101182	chr2	239299097	239299098	238390456	238390457	7310	hg38	N/A	enh34440	N/A	Enhatls108225	enhancer	E1913	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14905	0.44099		TRAF3IP1	chr2	238320440	238400897	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13108
enhrx-120700	chr3	169342644	169342645	169624856	169624857	7311	hg38	N/A	enh95643	N/A	Enhatls129146	enhancer	E1914	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054456	0.44099		MECOM	chr3	169083498	169663775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8829
enhrx-68583	chr17	14640223	14640224	14736906	14736907	7312	hg38	N/A	enh17019	N/A	Enhatls73599	enhancer	E1915	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16911	0.44099		HS3ST3B1	chr17	14301080	14349404	379525	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1852
enhrx-23482	chr10	105650109	105650110	103890351	103890352	7313	hg38	N/A	enh13486	fant36895	Enhatls25784	enhancer	E1916	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10032	0.44139		STN1	chr10	103856805	103918332	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5917
enhrx-19130	chr10	29908349	29908350	29619420	29619421	7314	hg38	N/A	enh13094	N/A	Enhatls20909	enhancer	E1917	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094284	0.44139		SVIL	chr10	29457337	29736959	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1565
enhrx-144061	chr6	108449240	108449241	108128036	108128037	7315	hg38	N/A	enh55926	N/A	Enhatls153948	enhancer	E1918	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017678	0.44221		OSTM1	chr6	108041408	108165840	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5649
enhrx-126552	chr4	88196671	88196672	87275519	87275520	7316	hg38	N/A	N/A	N/A	Enhatls135373	enhancer	E1919	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13377	0.44309		HSD17B13	chr4	87303788	87322886	27416	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4096
enhrx-123875	chr4	25402862	25402863	25401240	25401241	7317	hg38	N/A	N/A	N/A	Enhatls132564	enhancer	E1920	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18371	0.44309		ANAPC4	chr4	25377262	25418498	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1419
enhrx-143610	chr6	91580474	91580475	90870756	90870757	7318	hg38	N/A	enh97873	N/A	Enhatls153487	enhancer	E1921	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019089	0.44309		MAP3K7	chr6	90513572	90587072	281596	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5198
enhrx-101224	chr2	240190135	240190136	239268439	239268440	7319	hg38	N/A	enh6224	N/A	Enhatls108270	enhancer	E1922	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093844	0.44366		HDAC4	chr2	239048167	239401020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13150
enhrx-76024	chr18	499632	499633	499632	499633	7320	hg38	N/A	N/A	N/A	Enhatls81576	enhancer	E1923	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078252	0.44366		COLEC12	chr18	316736	500701	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	42
enhrx-56837	chr15	64238152	64238153	63945953	63945954	7321	hg38	N/A	enh3633	N/A	Enhatls61148	enhancer	E1924	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080858	0.4442		DAPK2	chr15	63907035	64072033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3539
enhrx-111080	chr22	43130602	43130603	42734596	42734597	7322	hg38	N/A	enh20234	fant61496	Enhatls118862	enhancer	E1925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015634	0.44439		CYB5R3	chr22	42615729	42720870	13513	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2911
enhrx-111080	chr22	43130602	43130603	42734596	42734597	7323	hg38	N/A	enh20234	fant61496	Enhatls118862	enhancer	E1925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015634	0.44439		A4GALT	chr22	42692120	42720870	13513	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2911
enhrx-64774	chr16	67485946	67485947	67452043	67452044	7324	hg38	N/A	N/A	N/A	Enhatls69514	enhancer	E1926	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072201	0.44439		ATP6V0D1	chr16	67438018	67481157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5069
enhrx-136229	chr5	145297050	145297051	145917487	145917488	7325	hg38	N/A	N/A	N/A	Enhatls145544	enhancer	E1927	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044569	0.4444		GRXCR2	chr5	145858520	145937126	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6020
enhrx-97259	chr2	177710592	177710593	176845864	176845865	7326	hg38	N/A	enh97018	N/A	Enhatls104094	enhancer	E1928	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0052384	0.4444		HNRNPA3	chr2	177212723	177223959	364777	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9185
enhrx-170796	chrX	10570899	10570900	10602859	10602860	7327	hg38	N/A	enh26153	N/A	Enhatls182766	enhancer	E1929	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10629	0.44441		MID1	chrX	10445309	10833654	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	513
enhrx-161365	chr8	122177608	122177609	121165368	121165369	7328	hg38	N/A	enh25255	N/A	Enhatls172343	enhancer	E1930	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05692	0.44482		SNTB1	chr8	120535744	120813273	351156	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-105054	chr20	48242345	48242346	49625808	49625809	7329	hg38	N/A	enh6524	N/A	Enhatls112328	enhancer	E1931	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020623	0.44546		B4GALT5	chr20	49632944	49713878	167	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3482
enhrx-14897	chr1	206848359	206848360	206675014	206675015	7330	hg38	N/A	enh12597	N/A	Enhatls16401	enhancer	E1932	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06134	0.44546		MAPKAPK2	chr1	206684904	206734281	6135	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14896
enhrx-158108	chr8	37921798	37921799	38064280	38064281	7331	hg38	N/A	enh24928	N/A	Enhatls168922	enhancer	E1933	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.034749	0.44615		EIF4EBP1	chr8	38030533	38060365	1843	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1899
enhrx-157996	chr8	33899944	33899945	34042426	34042427	7332	hg38	N/A	enh40898	N/A	Enhatls168802	enhancer	E1934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08093	0.44615		DUSP26	chr8	33591329	33600023	437525	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1787
enhrx-42805	chr12	116201951	116201952	115764146	115764147	7333	hg38	N/A	enh89672	N/A	Enhatls46225	enhancer	E1935	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087065	0.44615		MED13L	chr12	115958575	116277693	192047	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8115
enhrx-143892	chr6	104677122	104677123	104229247	104229248	7334	hg38	N/A	enh84336	N/A	Enhatls153772	enhancer	E1936	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10126	0.44695		HACE1	chr6	104728093	104859919	494194	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5480
enhrx-35161	chr12	6053984	6053985	5944818	5944819	7335	hg38	N/A	N/A	N/A	Enhatls38158	enhancer	E1937	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15675	0.44738		ANO2	chr12	5562650	5946232	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	471
enhrx-66325	chr16	87887984	87887985	87854378	87854379	7336	hg38	N/A	enh4182	N/A	Enhatls71221	enhancer	E1938	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14077	0.44738		SLC7A5	chr16	87830022	87869507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6620
enhrx-137717	chr5	175133593	175133594	175706590	175706591	7337	hg38	N/A	N/A	N/A	Enhatls147197	enhancer	E1939	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10136	0.44748		HRH2	chr5	175658029	175710756	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7508
enhrx-121904	chr3	190529796	190529797	190812007	190812008	7338	hg38	N/A	enh65800	N/A	Enhatls130456	enhancer	E1940	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038695	0.44748		GMNC	chr3	190852736	190862694	38671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10033
enhrx-116446	chr3	70803037	70803038	70753886	70753887	7339	hg38	N/A	enh97284	N/A	Enhatls124611	enhancer	E1941	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11775	0.44748		FOXP1	chr3	70954692	71583978	198789	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4575
enhrx-132419	chr5	61623754	61623755	62327927	62327928	7340	hg38	N/A	enh8477	N/A	Enhatls141520	enhancer	E1942	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14313	0.44748		KIF2A	chr5	62306161	62391025	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2210
enhrx-46561	chr13	69838963	69838964	69264831	69264832	7341	hg38	N/A	enh91007	N/A	Enhatls50276	enhancer	E1943	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054235	0.44759		KLHL1	chr13	69700593	70108493	433431	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2183
enhrx-1612	chr1	15064949	15064950	14738453	14738454	7342	hg38	N/A	enh11521	N/A	Enhatls1787	enhancer	E1944	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.002266	0.44806		KAZN	chr1	13892791	15118043	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1611
enhrx-116696	chr3	86158979	86158980	86109829	86109830	7343	hg38	N/A	N/A	N/A	Enhatls124881	enhancer	E1945	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072485	0.44806		CADM2	chr3	84958988	86074429	31991	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4825
enhrx-116348	chr3	67842265	67842266	67791841	67791842	7344	hg38	N/A	N/A	N/A	Enhatls124510	enhancer	E1946	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11935	0.44857		SUCLG2	chr3	67360459	67654612	130920	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4477
enhrx-39635	chr12	58931313	58931314	58537530	58537531	7345	hg38	N/A	N/A	N/A	Enhatls42844	enhancer	E1947	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071232	0.44857		LRIG3	chr12	58872148	58920504	318107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4945
enhrx-104870	chr20	46067647	46067648	47438903	47438904	7346	hg38	N/A	enh6513	N/A	Enhatls112130	enhancer	E1948	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012402	0.44857		NCOA3	chr20	47501886	47656877	57876	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3298
enhrx-63902	chr16	54041802	54041803	54007890	54007891	7347	hg38	N/A	N/A	N/A	Enhatls68585	enhancer	E1949	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11328	0.44857		FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4197
enhrx-123677	chr4	17781602	17781603	17779979	17779980	7348	hg38	N/A	N/A	N/A	Enhatls132359	enhancer	E1950	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098851	0.44857		FAM184B	chr4	17629305	17781621	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1221
enhrx-149729	chr7	46948567	46948568	46908969	46908970	7349	hg38	N/A	enh40172	N/A	Enhatls160039	enhancer	E1951	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11533	0.44857		TNS3	chr7	47275153	47582558	362886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-38155	chr12	50288400	50288401	49894617	49894618	7350	hg38	N/A	enh2340	N/A	Enhatls41308	enhancer	E1952	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030204	0.44906		FAIM2	chr12	49866895	49904217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3465
enhrx-158387	chr8	41366105	41366106	41508586	41508587	7351	hg38	N/A	N/A	N/A	Enhatls169220	enhancer	E1953	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041125	0.44926		GOLGA7	chr8	41488199	41511095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2178
enhrx-88365	chr2	9548980	9548981	9408851	9408852	7352	hg38	N/A	N/A	N/A	Enhatls94662	enhancer	E1954	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065126	0.44943		ITGB1BP1	chr2	9403474	9423528	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	291
enhrx-50519	chr14	65069782	65069783	64603064	64603065	7353	hg38	N/A	enh58582	N/A	Enhatls54494	enhancer	E1955	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0224	0.44972		PPP1R36	chr14	64549960	64589381	12803	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2476
enhrx-8926	chr1	110783118	110783119	110240496	110240497	7354	hg38	N/A	N/A	N/A	Enhatls9626	enhancer	E1956	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10897	0.44972		KCNC4	chr1	110210313	110249124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8925
enhrx-92788	chr2	95663791	95663792	94998046	94998047	7355	hg38	N/A	N/A	N/A	Enhatls99391	enhancer	E1957	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015897	0.44972		MAL	chr2	95025707	95053992	20948	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4714
enhrx-15881	chr1	224392760	224392761	224205058	224205059	7356	hg38	N/A	enh12716	N/A	Enhatls17435	enhancer	E1958	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0080219	0.45081		DEGS1	chr1	224175755	224193441	551	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15880
enhrx-49849	chr14	55171801	55171802	54705083	54705084	7357	hg38	N/A	N/A	N/A	Enhatls53783	enhancer	E1959	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19604	0.45081		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1806
enhrx-145622	chr6	139724747	139724748	139403610	139403611	7358	hg38	N/A	enh23686	N/A	Enhatls155653	enhancer	E1960	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1282	0.45081		CITED2	chr6	139371806	139374648	26317	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7210
enhrx-131824	chr5	42170548	42170549	42170446	42170447	7359	hg38	N/A	N/A	N/A	Enhatls140902	enhancer	E1961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14732	0.45081		FBXO4	chr5	41925253	41941743	226836	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1615
enhrx-171618	chrX	29155319	29155320	29137202	29137203	7360	hg38	N/A	N/A	N/A	Enhatls183647	enhancer	E1962	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026856	0.45081		IL1RAPL1	chrX	28587445	29956718	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1335
enhrx-130483	chr5	4029194	4029195	4029081	4029082	7361	hg38	N/A	enh90287	N/A	Enhatls139486	enhancer	E1963	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19749	0.45089		IRX1	chr5	3595831	3601403	424161	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	274
enhrx-18012	chr10	8119765	8119766	8077802	8077803	7362	hg38	N/A	enh12959	N/A	Enhatls19676	enhancer	E1964	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046335	0.45089		GATA3	chr10	8045377	8075198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	447
enhrx-73122	chr17	57203869	57203870	59126508	59126509	7363	hg38	N/A	N/A	N/A	Enhatls78502	enhancer	E1965	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0093787	0.45094		SKA2	chr17	59109856	59155248	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6391
enhrx-88518	chr2	11206188	11206189	11066062	11066063	7364	hg38	N/A	N/A	N/A	Enhatls94827	enhancer	E1966	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11855	0.45094		C2orf50	chr2	11133127	11151317	62742	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	444
enhrx-155199	chr7	142921078	142921079	143223985	143223986	7365	hg38	N/A	N/A	N/A	Enhatls165817	enhancer	E1967	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.028331	0.45112		TAS2R40	chr7	143222036	143223079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8011
enhrx-23060	chr10	102180463	102180464	100420706	100420707	7366	hg38	N/A	N/A	N/A	Enhatls25320	enhancer	E1968	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12158	0.45112		SCD	chr10	100347232	100364826	29833	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5495
enhrx-65888	chr16	81100948	81100949	81067343	81067344	7367	hg38	N/A	N/A	N/A	Enhatls70712	enhancer	E1969	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0066991	0.45112		C16orf46	chr16	81053496	81077238	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6183
enhrx-43615	chr12	123579483	123579484	123094936	123094937	7368	hg38	N/A	enh2666	N/A	Enhatls47085	enhancer	E1970	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047157	0.45112		PITPNM2	chr12	122983479	123151090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8925
enhrx-49982	chr14	57321306	57321307	56854588	56854589	7369	hg38	hs1579	enh51834	N/A	Enhatls53935	enhancer	E1971	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0052671	0.45112		OTX2	chr14	56799904	56816693	37254	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1939
enhrx-20422	chr10	63388757	63388758	61628999	61629000	7370	hg38	N/A	enh13248	N/A	Enhatls22504	enhancer	E1972	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062401	0.45151		CABCOCO1	chr10	61662928	61766766	24590	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2857
enhrx-151317	chr7	86476313	86476314	86846997	86846998	7371	hg38	N/A	enh56368	N/A	Enhatls161771	enhancer	E1973	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027515	0.45176		GRM3	chr7	86643908	86864879	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4129
enhrx-120987	chr3	177243965	177243966	177526177	177526178	7372	hg38	N/A	enh21140	N/A	Enhatls129465	enhancer	E1974	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15465	0.45176		TBL1XR1	chr3	177019343	177228000	288414	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9116
enhrx-116526	chr3	74352205	74352206	74303054	74303055	7373	hg38	N/A	N/A	N/A	Enhatls124706	enhancer	E1975	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16648	0.45176		CNTN3	chr3	74262567	74614659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4655
enhrx-43217	chr12	121323538	121323539	120885735	120885736	7374	hg38	N/A	enh2643	N/A	Enhatls46657	enhancer	E1976	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079005	0.45176		SPPL3	chr12	120762509	120904358	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8527
enhrx-120976	chr3	176638866	176638867	176921078	176921079	7375	hg38	N/A	enh21131	N/A	Enhatls129448	enhancer	E1977	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068599	0.45349		TBL1XR1	chr3	177019343	177228000	96237	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9105
enhrx-116335	chr3	67343422	67343423	67292998	67292999	7376	hg38	N/A	enh70648	N/A	Enhatls124495	enhancer	E1978	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10149	0.45349		SUCLG2	chr3	67360459	67654612	61749	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4464
enhrx-8160	chr1	97922582	97922583	97457026	97457027	7377	hg38	N/A	enh506	N/A	Enhatls8841	enhancer	E1979	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089792	0.45349		DPYD	chr1	97077742	97921049	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8159
enhrx-11338	chr1	157168025	157168026	157198235	157198236	7378	hg38	N/A	enh49984	N/A	Enhatls12612	enhancer	E1980	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025088	0.45351		ETV3	chr1	157121190	157138474	56483	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11337
enhrx-88346	chr2	9308406	9308407	9168277	9168278	7379	hg38	N/A	enh18242	N/A	Enhatls94633	enhancer	E1981	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14947	0.45351		ASAP2	chr2	9206764	9405683	10827	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	272
enhrx-80499	chr19	6801284	6801285	6801273	6801274	7380	hg38	N/A	enh4990	fant56109	Enhatls86358	enhancer	E1982	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17627	0.45351		VAV1	chr19	6772707	6857366	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1469
enhrx-43244	chr12	121604353	121604354	121166550	121166551	7381	hg38	N/A	N/A	N/A	Enhatls46684	enhancer	E1983	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067348	0.45351		P2RX7	chr12	121132875	121188032	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8554
enhrx-88471	chr2	10627469	10627470	10487343	10487344	7382	hg38	N/A	enh33049	N/A	Enhatls94776	enhancer	E1984	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11507	0.45532		ODC1	chr2	10439967	10448327	32733	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	397
enhrx-1204	chr1	10851955	10851956	10791898	10791899	7383	hg38	"hs408,hs2842"	enh58077	N/A	Enhatls1304	enhancer	E1985	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074817	0.45532		CASZ1	chr1	10636603	10796650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1203
enhrx-42837	chr12	117136087	117136088	116698282	116698283	7384	hg38	N/A	enh2613	N/A	Enhatls46261	enhancer	E1986	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13015	0.45532		SPRING1	chr12	116710170	116738069	9101	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8147
enhrx-13188	chr1	181071199	181071200	181102063	181102064	7385	hg38	N/A	enh12430	N/A	Enhatls14557	enhancer	E1987	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044708	0.45543		IER5	chr1	181088699	181092900	7488	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13187
enhrx-46444	chr13	55166459	55166460	54592324	54592325	7386	hg38	N/A	N/A	N/A	Enhatls50147	enhancer	E1988	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012116	0.45543		OLFM4	chr13	53028812	53052057	1522144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2066
enhrx-74847	chr17	74047418	74047419	76051337	76051338	7387	hg38	N/A	enh17384	N/A	Enhatls80329	enhancer	E1989	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.23736	0.45557		SRP68	chr17	76038774	76072517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8116
enhrx-158466	chr8	41901256	41901257	42043738	42043739	7388	hg38	N/A	N/A	N/A	Enhatls169298	enhancer	E1990	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14154	0.45571		KAT6A	chr8	41929478	42051994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2257
enhrx-27934	chr11	35513417	35513418	35491869	35491870	7389	hg38	N/A	N/A	N/A	Enhatls30402	enhancer	E1991	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041485	0.45571		PAMR1	chr11	35431822	35530300	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2603
enhrx-107356	chr21	42032589	42032590	40660663	40660664	7390	hg38	N/A	enh97209	N/A	Enhatls114804	enhancer	E1992	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085529	0.45571		DSCAM	chr21	40010998	40847158	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1239
enhrx-131408	chr5	36180727	36180728	36180625	36180626	7391	hg38	N/A	enh93383	N/A	Enhatls140457	enhancer	E1993	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02601	0.45571		SKP2	chr5	36151988	36196617	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1199
enhrx-94414	chr2	118314685	118314686	117557109	117557110	7392	hg38	N/A	enh53256	N/A	Enhatls101106	enhancer	E1994	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077968	0.45571		DDX18	chr2	117814690	117832377	257132	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6340
enhrx-160479	chr8	99177219	99177220	98164991	98164992	7393	hg38	N/A	enh25150	N/A	Enhatls171419	enhancer	E1995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0015276	0.45571		POP1	chr8	98117292	98159835	237	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4270
enhrx-2885	chr1	24959492	24959493	24633001	24633002	7394	hg38	N/A	N/A	N/A	Enhatls3215	enhancer	E1996	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15232	0.45571		SRRM1	chr1	24641230	24673281	3132	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2884
enhrx-123962	chr4	27102725	27102726	27101103	27101104	7395	hg38	N/A	enh71141	N/A	Enhatls132660	enhancer	E1997	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053131	0.45649		STIM2	chr4	26857677	27025381	67483	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1506
enhrx-123803	chr4	23964260	23964261	23962637	23962638	7396	hg38	N/A	enh110120	N/A	Enhatls132487	enhancer	E1998	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036002	0.45649		PPARGC1A	chr4	23792020	23890077	67446	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1347
enhrx-159822	chr8	82035766	82035767	81123531	81123532	7397	hg38	N/A	enh25101	N/A	Enhatls170723	enhancer	E1999	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2287	0.45735		PAG1	chr8	80967809	81112068	9323	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3613
enhrx-73495	chr17	60787502	60787503	62710141	62710142	7398	hg38	N/A	N/A	N/A	Enhatls78886	enhancer	E2000	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05767	0.45735		MARCHF10	chr17	62701313	62808344	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6764
enhrx-121074	chr3	179310923	179310924	179593135	179593136	7399	hg38	N/A	N/A	N/A	Enhatls129560	enhancer	E2001	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10316	0.45819		MRPL47	chr3	179588284	179604649	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9203
enhrx-103157	chr20	30199574	30199575	31611771	31611772	7400	hg38	N/A	enh19572	N/A	Enhatls110290	enhancer	E2002	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033117	0.45819		ID1	chr20	31605282	31606515	4528	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1585
enhrx-65568	chr16	72959030	72959031	72925131	72925132	7401	hg38	N/A	enh16767	N/A	Enhatls70359	enhancer	E2003	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17829	0.45825		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5863
enhrx-14238	chr1	201574163	201574164	201605035	201605036	7402	hg38	N/A	enh12524	N/A	Enhatls15671	enhancer	E2004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11968	0.45825		NAV1	chr1	201539126	201826969	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14237
enhrx-34788	chr12	711379	711380	602213	602214	7403	hg38	N/A	enh14436	N/A	Enhatls37748	enhancer	E2005	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048855	0.45825		NINJ2	chr12	564295	663589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	98
enhrx-3364	chr1	28479828	28479829	28153317	28153318	7404	hg38	N/A	enh183	N/A	Enhatls3731	enhancer	E2006	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046816	0.46011		PTAFR	chr1	28147165	28193936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3363
enhrx-149704	chr7	45731004	45731005	45691405	45691406	7405	hg38	N/A	enh40153	N/A	Enhatls160010	enhancer	E2007	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074609	0.46011		ADCY1	chr7	45574139	45723116	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2516
enhrx-161150	chr8	117584321	117584322	116572083	116572084	7406	hg38	N/A	enh41422	N/A	Enhatls172116	enhancer	E2008	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075332	0.46011		EIF3H	chr8	116642129	116766925	64739	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4941
enhrx-121946	chr3	192625772	192625773	192907983	192907984	7407	hg38	N/A	enh21233	N/A	Enhatls130504	enhancer	E2009	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1228	0.46011		MB21D2	chr3	192796814	192917856	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10075
enhrx-149753	chr7	47615732	47615733	47576134	47576135	7408	hg38	N/A	enh9786	N/A	Enhatls160067	enhancer	E2010	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12218	0.46011		TNS3	chr7	47275153	47582558	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2565
enhrx-82410	chr19	16725925	16725926	16615114	16615115	7409	hg38	N/A	enh5036	N/A	Enhatls88373	enhancer	E2011	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031176	0.46011		MED26	chr19	16574918	16629062	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3380
enhrx-92522	chr2	86783788	86783789	86556665	86556666	7410	hg38	N/A	enh57757	N/A	Enhatls99130	enhancer	E2012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020755	0.4604		RNF103-CHMP3	chr2	86505667	86721122	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4448
enhrx-92522	chr2	86783788	86783789	86556665	86556666	7411	hg38	N/A	enh57757	N/A	Enhatls99130	enhancer	E2012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020755	0.4604		CHMP3	chr2	86503429	86563479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4448
enhrx-162042	chr8	140770645	140770646	139758402	139758403	7412	hg38	N/A	enh98222	N/A	Enhatls173090	enhancer	E2013	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022157	0.4604		TRAPPC9	chr8	139727724	140458579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5833
enhrx-92353	chr2	85381659	85381660	85154536	85154537	7413	hg38	N/A	enh33485	N/A	Enhatls98942	enhancer	E2014	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10996	0.4604		TCF7L1	chr2	85133391	85310387	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4279
enhrx-15881	chr1	224385096	224385097	224197394	224197395	7414	hg38	N/A	enh12716	N/A	Enhatls17435	enhancer	E2015	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075597	0.4604		DEGS1	chr1	224175755	224193441	551	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15880
enhrx-18204	chr10	13376812	13376813	13334812	13334813	7415	hg38	N/A	N/A	N/A	Enhatls19891	enhancer	E2016	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16468	0.4604		SEPHS1	chr10	13317427	13348298	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	639
enhrx-15604	chr1	219750734	219750735	219577392	219577393	7416	hg38	N/A	N/A	N/A	Enhatls17145	enhancer	E2017	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083552	0.46041		ZC3H11B	chr1	219608011	219613105	29849	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15603
enhrx-147982	chr7	8294463	8294464	8254833	8254834	7417	hg38	N/A	enh89079	N/A	Enhatls158145	enhancer	E2018	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18027	0.46041		ICA1	chr7	8113183	8262687	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	794
enhrx-100178	chr2	226480438	226480439	225615722	225615723	7418	hg38	N/A	enh97086	N/A	Enhatls107172	enhancer	E2019	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072768	0.46101		NYAP2	chr2	225399709	225729887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12104
enhrx-121780	chr3	186658194	186658195	186940405	186940406	7419	hg38	N/A	enh7748	N/A	Enhatls130321	enhancer	E2020	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066963	0.46101		ST6GAL1	chr3	186930525	187078553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9909
enhrx-176146	chrX	127734253	127734254	128600275	128600276	7420	hg38	N/A	N/A	N/A	Enhatls188350	enhancer	E2021	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21593	0.46284		ACTRT1	chrX	128050961	128052403	521170	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5863
enhrx-133809	chr5	89480832	89480833	90185015	90185016	7421	hg38	N/A	N/A	N/A	Enhatls142952	enhancer	E2022	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020011	0.46284		CETN3	chr5	90392256	90409766	204329	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3600
enhrx-34792	chr12	834488	834489	725322	725323	7422	hg38	N/A	enh2135	N/A	Enhatls37755	enhancer	E2023	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016998	0.46284		WNK1	chr12	752578	911452	21150	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	102
enhrx-136559	chr5	149045323	149045324	149665760	149665761	7423	hg38	N/A	enh66089	N/A	Enhatls145894	enhancer	E2024	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077563	0.46284		ARHGEF37	chr5	149551946	149634968	29025	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6350
enhrx-173102	chrX	54722817	54722818	54696384	54696385	7424	hg38	N/A	enh61698	N/A	Enhatls185297	enhancer	E2025	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1035	0.46284		ITIH6	chrX	54748917	54798255	50536	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2819
enhrx-40953	chr12	94546674	94546675	94152898	94152899	7425	hg38	N/A	N/A	N/A	Enhatls44267	enhancer	E2026	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0979	0.46284		PLXNC1	chr12	94148576	94307675	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6263
enhrx-93391	chr2	100417907	100417908	99801445	99801446	7426	hg38	N/A	enh33510	N/A	Enhatls100021	enhancer	E2027	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074131	0.46284		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5317
enhrx-12439	chr1	170066871	170066872	170097730	170097731	7427	hg38	N/A	enh74408	N/A	Enhatls13770	enhancer	E2028	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024458	0.46285		KIFAP3	chr1	169921325	170074738	19587	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12438
enhrx-16675	chr1	234659446	234659447	234523700	234523701	7428	hg38	N/A	enh991	fant5268	Enhatls18276	enhancer	E2029	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085764	0.46285		TARBP1	chr1	234391312	234479179	44306	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16674
enhrx-46809	chr13	77880811	77880812	77306676	77306677	7429	hg38	N/A	enh2950	N/A	Enhatls50532	enhancer	E2030	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017191	0.46285		MYCBP2	chr13	77042473	77327094	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2431
enhrx-131572	chr5	37801812	37801813	37801710	37801711	7430	hg38	N/A	enh105926	N/A	Enhatls140626	enhancer	E2031	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08611	0.46285		GDNF	chr5	37812676	37840041	9844	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1363
enhrx-101986	chr20	3613389	3613390	3632742	3632743	7431	hg38	N/A	N/A	N/A	Enhatls109054	enhancer	E2032	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019292	0.46315		ATRN	chr20	3471017	3651118	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	414
enhrx-123228	chr4	6753447	6753448	6751720	6751721	7432	hg38	N/A	enh21339	N/A	Enhatls131861	enhancer	E2033	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045816	0.46324		KIAA0232	chr4	6782641	6884170	14345	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	772
enhrx-35047	chr12	3904834	3904835	3795668	3795669	7433	hg38	N/A	N/A	N/A	Enhatls38037	enhancer	E2034	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12057	0.46324		PARP11	chr12	3808860	3873448	6902	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	357
enhrx-121116	chr3	179681020	179681021	179963232	179963233	7434	hg38	N/A	enh7701	N/A	Enhatls129605	enhancer	E2035	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0093609	0.4634		PEX5L	chr3	179794957	180037053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9245
enhrx-161729	chr8	132928919	132928920	131916672	131916673	7435	hg38	N/A	enh25334	N/A	Enhatls172760	enhancer	E2036	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14053	0.4634		EFR3A	chr8	131904092	132013642	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5520
enhrx-116637	chr3	80433931	80433932	80384781	80384782	7436	hg38	N/A	N/A	N/A	Enhatls124821	enhancer	E2037	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01969	0.46525		ROBO1	chr3	78597238	79767998	527950	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4766
enhrx-159560	chr8	71731392	71731393	70819157	70819158	7437	hg38	N/A	N/A	N/A	Enhatls170438	enhancer	E2038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19206	0.46525		XKR9	chr8	70669338	70735942	39879	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3351
enhrx-21756	chr10	88316505	88316506	86556748	86556749	7438	hg38	N/A	enh96123	N/A	Enhatls23949	enhancer	E2039	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015402	0.46525		WAPL	chr10	86435255	86521792	32837	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4191
enhrx-149199	chr7	37071710	37071711	37032105	37032106	7439	hg38	N/A	N/A	fant26160	Enhatls159469	enhancer	E2040	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1314	0.46525		ELMO1	chr7	36852905	37449223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2011
enhrx-102402	chr20	12891545	12891546	12910897	12910898	7440	hg38	N/A	N/A	N/A	Enhatls109495	enhancer	E2041	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051557	0.46525		SPTLC3	chr20	13008971	13169103	96775	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	830
enhrx-88257	chr2	5861069	5861070	5720937	5720938	7441	hg38	N/A	enh44685	N/A	Enhatls94514	enhancer	E2042	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14656	0.46525		SOX11	chr2	5692383	5701385	16974	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	183
enhrx-76855	chr18	18747769	18747770	21167808	21167809	7442	hg38	N/A	enh32488	N/A	Enhatls82469	enhancer	E2043	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13132	0.46525		ROCK1	chr18	20946905	21111813	50004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	873
enhrx-138468	chr6	1132267	1132268	1132032	1132033	7443	hg38	N/A	enh38709	fant21164	Enhatls148030	enhancer	E2044	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037006	0.46525		FOXQ1	chr6	1312097	1314758	180027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	56
enhrx-49952	chr14	56172884	56172885	55706166	55706167	7444	hg38	N/A	enh47757	N/A	Enhatls53902	enhancer	E2045	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019693	0.46574		KTN1	chr14	55559071	55701526	2462	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1909
enhrx-57384	chr15	69777305	69777306	69484966	69484967	7445	hg38	N/A	enh44142	N/A	Enhatls61742	enhancer	E2046	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0038923	0.46579		RPLP1	chr15	69452813	69456205	23544	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4086
enhrx-73847	chr17	64708195	64708196	66712077	66712078	7446	hg38	N/A	enh44477	N/A	Enhatls79283	enhancer	E2047	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14198	0.4658		PRKCA	chr17	66302612	66810743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7116
enhrx-42835	chr12	116728193	116728194	116290388	116290389	7447	hg38	N/A	enh15023	N/A	Enhatls46255	enhancer	E2048	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047367	0.46629		MED13L	chr12	115958575	116277693	6728	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-109026	chr22	24519743	24519744	24123776	24123777	7448	hg38	N/A	N/A	N/A	Enhatls116661	enhancer	E2049	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11392	0.4685		CABIN1	chr22	24011191	24178628	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	857
enhrx-89704	chr2	30978966	30978967	30756100	30756101	7449	hg38	N/A	N/A	N/A	Enhatls96089	enhancer	E2050	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16703	0.4685		CAPN13	chr2	30722770	30807446	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1630
enhrx-93430	chr2	101520548	101520549	100904086	100904087	7450	hg38	N/A	enh5745	N/A	Enhatls100063	enhancer	E2051	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1198	0.4685		NPAS2	chr2	100820138	100996829	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5356
enhrx-42833	chr12	116703753	116703754	116265948	116265949	7451	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E2052	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030404	0.4685		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-78810	chr18	71863584	71863585	74196349	74196350	7452	hg38	N/A	enh95534	N/A	Enhatls84551	enhancer	E2053	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15706	0.4685		TIMM21	chr18	74148522	74160531	33800	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2828
enhrx-160818	chr8	104457898	104457899	103445670	103445671	7453	hg38	N/A	enh41317	fant30426	Enhatls171769	enhancer	E2054	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10252	0.46853		DCAF13	chr8	103414713	103443453	2212	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4609
enhrx-173112	chrX	54821410	54821411	54794977	54794978	7454	hg38	N/A	N/A	N/A	Enhatls185307	enhancer	E2055	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059118	0.46857		ITIH6	chrX	54748917	54798255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2829
enhrx-33452	chr11	117574190	117574191	117703475	117703476	7455	hg38	N/A	enh43627	N/A	Enhatls36306	enhancer	E2056	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092386	0.46869		DSCAML1	chr11	117427771	117817525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8121
enhrx-133240	chr5	75753993	75753994	76458168	76458169	7456	hg38	N/A	enh22372	N/A	Enhatls142360	enhancer	E2057	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045817	0.46869		IQGAP2	chr5	76403284	76708132	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3031
enhrx-116327	chr3	66526248	66526249	66475824	66475825	7457	hg38	N/A	enh7279	N/A	Enhatls124488	enhancer	E2058	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13352	0.46878		LRIG1	chr3	66378796	66501022	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4456
enhrx-21455	chr10	79078795	79078796	77319037	77319038	7458	hg38	N/A	enh28254	N/A	Enhatls23603	enhancer	E2059	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040705	0.47034		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-21638	chr10	82800862	82800863	81041106	81041107	7459	hg38	N/A	N/A	N/A	Enhatls23820	enhancer	E2060	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.028435	0.47034		SH2D4B	chr10	80537901	80646560	391980	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-68533	chr17	12803983	12803984	12900666	12900667	7460	hg38	N/A	enh96732	N/A	Enhatls73549	enhancer	E2061	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05399	0.47037		ARHGAP44	chr17	12789497	12991643	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1802
enhrx-90011	chr2	36877383	36877384	36650240	36650241	7461	hg38	N/A	N/A	N/A	Enhatls96426	enhancer	E2062	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10794	0.47123		FEZ2	chr2	36552257	36646087	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1937
enhrx-62904	chr16	30065090	30065091	30053769	30053770	7462	hg38	N/A	N/A	N/A	Enhatls67570	enhancer	E2063	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075258	0.47144		TLCD3B	chr16	30024426	30052978	242	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3199
enhrx-41251	chr12	100241924	100241925	99848146	99848147	7463	hg38	N/A	enh96346	N/A	Enhatls44586	enhancer	E2064	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051028	0.4721		ANKS1B	chr12	98734683	99984936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6561
enhrx-15085	chr1	208137263	208137264	207963918	207963919	7464	hg38	N/A	enh12608	N/A	Enhatls16598	enhancer	E2065	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057015	0.4721		CD34	chr1	207880971	207911402	50563	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15084
enhrx-141264	chr6	42096986	42096987	42129248	42129249	7465	hg38	N/A	N/A	N/A	Enhatls151022	enhancer	E2066	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035709	0.4721		C6orf132	chr6	42101118	42142620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2852
enhrx-16393	chr1	229718312	229718313	229582565	229582566	7466	hg38	N/A	enh980	N/A	Enhatls17983	enhancer	E2067	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073219	0.4721		TAF5L	chr1	229593133	229626122	8634	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16392
enhrx-171159	chrX	18028527	18028528	18010407	18010408	7467	hg38	N/A	enh98316	N/A	Enhatls183153	enhancer	E2068	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12963	0.4721		RAI2	chrX	17800048	17861337	147029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	876
enhrx-14463	chr1	203138997	203138998	203169869	203169870	7468	hg38	N/A	N/A	N/A	Enhatls15917	enhancer	E2069	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18033	0.4721		MYBPH	chr1	203167810	203175826	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14462
enhrx-120044	chr3	150516102	150516103	150798315	150798316	7469	hg38	N/A	enh21033	N/A	Enhatls128435	enhancer	E2070	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13642	0.4721		SIAH2	chr3	150741124	150763431	17988	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8173
enhrx-31037	chr11	72109283	72109284	72398239	72398240	7470	hg38	N/A	enh92307	N/A	Enhatls33745	enhancer	E2071	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12439	0.4721		CLPB	chr11	72285494	72434629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5706
enhrx-50584	chr14	65540799	65540800	65074081	65074082	7471	hg38	N/A	enh15688	N/A	Enhatls54559	enhancer	E2072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089585	0.4721		MAX	chr14	65006173	65102695	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-21513	chr10	80846761	80846762	79087004	79087005	7472	hg38	N/A	enh1378	N/A	Enhatls23676	enhancer	E2073	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0056744	0.4721		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3948
enhrx-15410	chr1	214503800	214503801	214330457	214330458	7473	hg38	N/A	N/A	N/A	Enhatls16937	enhancer	E2074	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11229	0.4721		SMYD2	chr1	214281158	214337131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15409
enhrx-72318	chr17	46834356	46834357	48756994	48756995	7474	hg38	N/A	enh57710	N/A	Enhatls77626	enhancer	E2075	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066275	0.4721		TTLL6	chr17	48762233	48817229	2361	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5587
enhrx-108344	chr22	18320307	18320308	17837541	17837542	7475	hg38	N/A	enh63055	N/A	Enhatls115865	enhancer	E2076	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18277	0.4721		MICAL3	chr22	17787648	18024561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	175
enhrx-113299	chr3	32448691	32448692	32407199	32407200	7476	hg38	N/A	enh7086	N/A	Enhatls121231	enhancer	E2077	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019771	0.4721		CMTM7	chr3	32391697	32455528	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1428
enhrx-50988	chr14	72452309	72452310	71985592	71985593	7477	hg38	N/A	enh64797	N/A	Enhatls54989	enhancer	E2078	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074771	0.4721		RGS6	chr14	71932428	72566530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2945
enhrx-45835	chr13	45479295	45479296	44905160	44905161	7478	hg38	N/A	enh15281	N/A	Enhatls49473	enhancer	E2079	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0087581	0.4721		NUFIP1	chr13	44939248	44989471	28949	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1457
enhrx-126172	chr4	81844198	81844199	80923044	80923045	7479	hg38	N/A	enh21628	N/A	Enhatls134985	enhancer	E2080	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0468	0.473		CFAP299	chr4	80335729	80963750	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3716
enhrx-1511	chr1	12556729	12556730	12496675	12496676	7480	hg38	N/A	enh11513	N/A	Enhatls1632	enhancer	E2081	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10457	0.473		VPS13D	chr1	12230029	12512047	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1510
enhrx-121200	chr3	181557200	181557201	181839412	181839413	7481	hg38	N/A	enh97418	N/A	Enhatls129689	enhancer	E2082	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0014203	0.473		SOX2	chr3	181711924	181714436	122522	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9329
enhrx-42381	chr12	111475262	111475263	111037458	111037459	7482	hg38	N/A	enh43823	N/A	Enhatls45783	enhancer	E2083	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.002408	0.47353		CUX2	chr12	111034164	111350554	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7691
enhrx-49983	chr14	57524716	57524717	57057998	57057999	7483	hg38	N/A	enh47764	N/A	Enhatls53938	enhancer	E2084	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062081	0.47372		EXOC5	chr14	57200506	57268905	126670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1940
enhrx-16201	chr1	228124813	228124814	227937112	227937113	7484	hg38	N/A	enh12738	N/A	Enhatls17790	enhancer	E2085	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045896	0.47372		WNT9A	chr1	227918655	227947932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16200
enhrx-77530	chr18	33103542	33103543	35523578	35523579	7485	hg38	N/A	enh17629	N/A	Enhatls83187	enhancer	E2086	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11385	0.47372		INO80C	chr18	35452229	35497960	23650	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1548
enhrx-84784	chr19	40837198	40837199	40331291	40331292	7486	hg38	N/A	enh18071	N/A	Enhatls90887	enhancer	E2087	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087426	0.47372		C19orf47	chr19	40319535	40348527	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5754
enhrx-140814	chr6	36617830	36617831	36650053	36650054	7487	hg38	N/A	enh9086	N/A	Enhatls150532	enhancer	E2088	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089109	0.4745		CDKN1A	chr6	36676459	36687337	15621	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2402
enhrx-167415	chr9	116162416	116162417	113400136	113400137	7488	hg38	N/A	N/A	N/A	Enhatls179170	enhancer	E2089	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0072267	0.47468		ALAD	chr9	113386311	113401290	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4682
enhrx-129837	chr4	183159545	183159546	182238392	182238393	7489	hg38	N/A	enh21971	N/A	Enhatls138789	enhancer	E2090	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25084	0.47468		TENM3	chr4	182144689	182803024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7381
enhrx-68776	chr17	16922097	16922098	17018783	17018784	7490	hg38	N/A	enh4276	fant52045	Enhatls73797	enhancer	E2091	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014362	0.47468		MPRIP	chr17	17042456	17217679	23531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2045
enhrx-135515	chr5	133927868	133927869	134592178	134592179	7491	hg38	N/A	enh8698	N/A	Enhatls144772	enhancer	E2092	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043726	0.47468		JADE2	chr5	134524311	134583230	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5306
enhrx-145517	chr6	138483747	138483748	138162610	138162611	7492	hg38	N/A	N/A	N/A	Enhatls155539	enhancer	E2093	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023645	0.47468		ARFGEF3	chr6	138161938	138344663	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7105
enhrx-17610	chr10	560182	560183	514242	514243	7493	hg38	N/A	enh50294	fant34315	Enhatls19237	enhancer	E2094	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067338	0.47468		DIP2C	chr10	274200	689668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	45
enhrx-24428	chr10	123084565	123084566	121325051	121325052	7494	hg38	N/A	enh13576	N/A	Enhatls26799	enhancer	E2095	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022567	0.47468		FGFR2	chr10	121478331	121598458	133431	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6863
enhrx-160418	chr8	97940825	97940826	96928597	96928598	7495	hg38	N/A	enh25138	N/A	Enhatls171351	enhancer	E2096	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047707	0.47468		CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4209
enhrx-105148	chr20	50015858	50015859	51399321	51399322	7496	hg38	N/A	enh19745	N/A	Enhatls112453	enhancer	E2097	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022104	0.47531		NFATC2	chr20	51386956	51562831	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3576
enhrx-126006	chr4	78526503	78526504	77605349	77605350	7497	hg38	N/A	N/A	N/A	Enhatls134808	enhancer	E2098	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20819	0.47531		CXCL13	chr4	77511752	77611834	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3550
enhrx-67013	chr17	2287116	2287117	2383822	2383823	7498	hg38	N/A	N/A	N/A	Enhatls71965	enhancer	E2099	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014538	0.47531		SGSM2	chr17	2337500	2381058	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	282
enhrx-171047	chrX	15763508	15763509	15745385	15745386	7499	hg38	N/A	N/A	N/A	Enhatls183034	enhancer	E2100	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14358	0.47531		CA5B	chrX	15688829	15788411	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	764
enhrx-14029	chr1	200153456	200153457	200184328	200184329	7500	hg38	N/A	enh27413	N/A	Enhatls15457	enhancer	E2101	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080864	0.47531		NR5A2	chr1	200027613	200177420	178	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14028
enhrx-109972	chr22	33206785	33206786	32810799	32810800	7501	hg38	N/A	enh20161	N/A	Enhatls117677	enhancer	E2102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14353	0.47531		SYN3	chr22	32507819	33058381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1803
enhrx-109972	chr22	33206785	33206786	32810799	32810800	7502	hg38	N/A	enh20161	N/A	Enhatls117677	enhancer	E2102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14353	0.47531		TIMP3	chr22	32801704	32863041	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1803
enhrx-159637	chr8	74104107	74104108	73191872	73191873	7503	hg38	N/A	enh46594	N/A	Enhatls170518	enhancer	E2103	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.2496	0.47531		C8orf89	chr8	73241330	73259530	47331	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3428
enhrx-112562	chr3	13006442	13006443	12964942	12964943	7504	hg38	N/A	enh20346	N/A	Enhatls120448	enhancer	E2104	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078751	0.47531		IQSEC1	chr3	12897042	13283281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	691
enhrx-75471	chr17	78680584	78680585	80706784	80706785	7505	hg38	N/A	enh107729	N/A	Enhatls80992	enhancer	E2105	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086897	0.47548		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-50785	chr14	69095615	69095616	68628898	68628899	7506	hg38	N/A	enh15720	N/A	Enhatls54769	enhancer	E2106	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068863	0.4767		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2742
enhrx-161714	chr8	131821105	131821106	130808859	130808860	7507	hg38	N/A	enh41593	N/A	Enhatls172744	enhancer	E2107	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099432	0.4767		ADCY8	chr8	130780300	131040909	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-49108	chr14	35811880	35811881	35342674	35342675	7508	hg38	N/A	enh15582	N/A	Enhatls53011	enhancer	E2108	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037443	0.4767		PSMA6	chr14	35278632	35317493	24553	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1065
enhrx-52768	chr14	102563968	102563969	102097631	102097632	7509	hg38	N/A	enh15961	N/A	Enhatls56908	enhancer	E2109	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082646	0.4767		HSP90AA1	chr14	102080741	102139699	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4725
enhrx-147144	chr6	170532995	170532996	170223205	170223206	7510	hg38	N/A	enh46287	N/A	Enhatls157259	enhancer	E2110	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10911	0.4767		DLL1	chr6	170282205	170306565	56831	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8732
enhrx-157049	chr8	19203039	19203040	19345528	19345529	7511	hg38	N/A	enh49372	N/A	Enhatls167775	enhancer	E2111	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052009	0.4767		SH2D4A	chr8	19313692	19396218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	840
enhrx-132417	chr5	61576058	61576059	62280231	62280232	7512	hg38	N/A	enh22278	N/A	Enhatls141518	enhancer	E2112	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14736	0.4767		KIF2A	chr5	62306161	62391025	15734	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2208
enhrx-13188	chr1	181081774	181081775	181112638	181112639	7513	hg38	N/A	enh12430	fant3854	Enhatls14557	enhancer	E2113	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00082367	0.47741		IER5	chr1	181088699	181092900	19655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13187
enhrx-159013	chr8	58491151	58491152	57578592	57578593	7514	hg38	N/A	enh41017	N/A	Enhatls169858	enhancer	E2114	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023291	0.47741		FAM110B	chr8	57994522	58148788	410607	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2804
enhrx-38514	chr12	52738677	52738678	52344893	52344894	7515	hg38	N/A	enh80197	N/A	Enhatls41690	enhancer	E2115	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13095	0.47781		KRT85	chr12	52360005	52367481	6075	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3824
enhrx-13281	chr1	182603080	182603081	182633945	182633946	7516	hg38	N/A	enh797	N/A	Enhatls14657	enhancer	E2116	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21592	0.47797		RGS8	chr1	182641815	182684587	5416	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13280
enhrx-155499	chr7	149442094	149442095	149745005	149745006	7517	hg38	N/A	N/A	N/A	Enhatls166139	enhancer	E2117	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056266	0.47797		KRBA1	chr7	149714780	149734575	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8311
enhrx-11160	chr1	156441577	156441578	156471785	156471786	7518	hg38	N/A	enh12298	N/A	Enhatls12405	enhancer	E2118	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09661	0.47871		MEF2D	chr1	156463726	156500779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11159
enhrx-133091	chr5	73877037	73877038	74581212	74581213	7519	hg38	N/A	enh22358	N/A	Enhatls142210	enhancer	E2119	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039513	0.47871		ENC1	chr5	74627405	74641424	42236	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2882
enhrx-131155	chr5	32255242	32255243	32255136	32255137	7520	hg38	N/A	enh77597	N/A	Enhatls140186	enhancer	E2120	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17923	0.47871		MTMR12	chr5	32226993	32312969	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	946
enhrx-52417	chr14	95815214	95815215	95348877	95348878	7521	hg38	N/A	N/A	N/A	Enhatls56527	enhancer	E2121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16492	0.47891		CLMN	chr14	95181939	95319908	23931	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4374
enhrx-168078	chr9	127331690	127331691	124569411	124569412	7522	hg38	N/A	enh25996	N/A	Enhatls179899	enhancer	E2122	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17082	0.47891		NR6A1	chr9	124517274	124771311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5345
enhrx-16123	chr1	226899176	226899177	226711475	226711476	7523	hg38	N/A	enh973	N/A	Enhatls17705	enhancer	E2123	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057422	0.47891		ITPKB	chr1	226631689	226739323	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16122
enhrx-85932	chr19	47538894	47538895	47035636	47035637	7524	hg38	N/A	N/A	N/A	Enhatls92105	enhancer	E2124	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064078	0.47896		NPAS1	chr19	47019836	47045775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6902
enhrx-17118	chr1	241555456	241555457	241392156	241392157	7525	hg38	N/A	enh74506	N/A	Enhatls18730	enhancer	E2125	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099993	0.47953		RGS7	chr1	240767635	241357374	32692	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17117
enhrx-64071	chr16	56848862	56848863	56814950	56814951	7526	hg38	N/A	enh4045	N/A	Enhatls68770	enhancer	E2126	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12912	0.47953		NUP93	chr16	56730117	56850286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4366
enhrx-41692	chr12	104478268	104478269	104084490	104084491	7527	hg38	N/A	N/A	N/A	Enhatls45057	enhancer	E2127	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043483	0.47992		HCFC2	chr12	104064530	104106524	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7002
enhrx-17608	chr10	482193	482194	436253	436254	7528	hg38	N/A	enh79479	N/A	Enhatls19234	enhancer	E2128	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044259	0.47992		DIP2C	chr10	274200	689668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	43
enhrx-100123	chr2	225472969	225472970	224608252	224608253	7529	hg38	N/A	enh97083	N/A	Enhatls107117	enhancer	E2129	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024576	0.48112		CUL3	chr2	224470149	224585397	20772	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12049
enhrx-100966	chr2	237353056	237353057	236444413	236444414	7530	hg38	N/A	N/A	N/A	Enhatls108005	enhancer	E2130	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082247	0.48159		IQCA1	chr2	236324146	236507535	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12892
enhrx-161610	chr8	126285503	126285504	125273261	125273262	7531	hg38	N/A	enh10519	N/A	Enhatls172605	enhancer	E2131	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013443	0.48217		NSMCE2	chr8	125091678	125367120	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5401
enhrx-105299	chr20	55734507	55734508	57159451	57159452	7532	hg38	N/A	enh65485	N/A	Enhatls112614	enhancer	E2132	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043153	0.48217		BMP7	chr20	57168752	57266641	9286	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-153296	chr7	107744222	107744223	108103777	108103778	7533	hg38	N/A	N/A	N/A	Enhatls163817	enhancer	E2133	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13604	0.48217		LAMB4	chr7	108023547	108130361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6108
enhrx-98499	chr2	201519838	201519839	200655115	200655116	7534	hg38	N/A	N/A	N/A	Enhatls105381	enhancer	E2134	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16829	0.48341		AOX1	chr2	200586013	200677064	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10425
enhrx-58437	chr15	81783965	81783966	81491624	81491625	7535	hg38	N/A	N/A	N/A	Enhatls62865	enhancer	E2135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073337	0.48341		TMC3	chr15	81331087	81374213	113822	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5139
enhrx-133828	chr5	89844068	89844069	90548251	90548252	7536	hg38	N/A	enh57907	N/A	Enhatls142972	enhancer	E2136	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0027785	0.48341		ADGRV1	chr5	90529343	91164437	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3619
enhrx-104495	chr20	43477472	43477473	44848831	44848832	7537	hg38	N/A	N/A	N/A	Enhatls111751	enhancer	E2137	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018682	0.48341		RIMS4	chr20	44751807	44810546	4794	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2923
enhrx-161644	chr8	128775857	128775858	127763611	127763612	7538	hg38	N/A	enh10526	N/A	Enhatls172651	enhancer	E2138	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21957	0.48341		MYC	chr8	127735433	127742951	17866	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5435
enhrx-59087	chr15	90578906	90578907	90035674	90035675	7539	hg38	N/A	enh3787	fant49299	Enhatls63627	enhancer	E2139	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059629	0.48341		ZNF710	chr15	90001323	90082191	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5789
enhrx-107393	chr21	42805719	42805720	41433792	41433793	7540	hg38	N/A	N/A	N/A	Enhatls114844	enhancer	E2140	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092909	0.48341		MX1	chr21	41420019	41470071	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1276
enhrx-88780	chr2	18391674	18391675	18210408	18210409	7541	hg38	N/A	enh33109	N/A	Enhatls95116	enhancer	E2141	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1036	0.48367		KCNS3	chr2	17877846	17932958	274382	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	706
enhrx-83415	chr19	31771556	31771557	31280650	31280651	7542	hg38	N/A	N/A	N/A	Enhatls89463	enhancer	E2142	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029384	0.48377		TSHZ3	chr19	31274944	31349436	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4385
enhrx-23862	chr10	114571790	114571791	112812031	112812032	7543	hg38	N/A	enh13506	N/A	Enhatls26194	enhancer	E2143	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.001577	0.48377		VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6297
enhrx-129550	chr4	170001493	170001494	169080342	169080343	7544	hg38	N/A	enh21935	N/A	Enhatls138489	enhancer	E2144	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098837	0.48377		SH3RF1	chr4	169094258	169270956	6713	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7094
enhrx-115794	chr3	55603279	55603280	55569251	55569252	7545	hg38	N/A	enh7228	N/A	Enhatls123889	enhancer	E2145	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04276	0.48377		ERC2	chr3	55508310	56469095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3923
enhrx-160181	chr8	93828146	93828147	92815918	92815919	7546	hg38	N/A	N/A	N/A	Enhatls171102	enhancer	E2146	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042158	0.48377		TRIQK	chr8	92883531	93017673	49615	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3972
enhrx-113725	chr3	38510497	38510498	38469006	38469007	7547	hg38	N/A	enh54081	N/A	Enhatls121694	enhancer	E2147	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026351	0.48377		ACVR2B	chr3	38453889	38493142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1854
enhrx-58440	chr15	82333411	82333412	82041070	82041071	7548	hg38	N/A	N/A	fant49106	Enhatls62868	enhancer	E2148	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14405	0.48377		MEX3B	chr15	82041777	82046119	570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5142
enhrx-116480	chr3	72366816	72366817	72317665	72317666	7549	hg38	N/A	enh45446	N/A	Enhatls124657	enhancer	E2149	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12359	0.48377		RYBP	chr3	72371824	72446621	52827	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4609
enhrx-161527	chr8	125172878	125172879	124160637	124160638	7550	hg38	N/A	enh56833	N/A	Enhatls172518	enhancer	E2150	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1065	0.48377		FER1L6	chr8	123851986	124120061	37444	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5318
enhrx-121943	chr3	192187439	192187440	192469650	192469651	7551	hg38	N/A	N/A	N/A	Enhatls130501	enhancer	E2151	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13968	0.48377		FGF12	chr3	192139389	192767764	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10072
enhrx-113338	chr3	32914705	32914706	32873213	32873214	7552	hg38	N/A	N/A	N/A	Enhatls121271	enhancer	E2152	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0038484	0.48377		TRIM71	chr3	32817996	32897824	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1467
enhrx-18016	chr10	8441881	8441882	8399918	8399919	7553	hg38	N/A	enh12976	N/A	Enhatls19681	enhancer	E2153	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11482	0.48377		GATA3	chr10	8045377	8075198	324585	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	451
enhrx-115797	chr3	55825138	55825139	55791110	55791111	7554	hg38	N/A	enh82533	N/A	Enhatls123893	enhancer	E2154	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059973	0.48377		ERC2	chr3	55508310	56469095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3926
enhrx-72414	chr17	47468654	47468655	49391292	49391293	7555	hg38	N/A	enh4461	fant52937	Enhatls77729	enhancer	E2155	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060507	0.48377		PHB1	chr17	49404048	49414905	12692	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5683
enhrx-139006	chr6	15089875	15089876	15089644	15089645	7556	hg38	N/A	enh23063	N/A	Enhatls148610	enhancer	E2156	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071904	0.48377		JARID2	chr6	15246068	15522042	153445	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-160421	chr8	98279867	98279868	97267639	97267640	7557	hg38	N/A	enh93743	N/A	Enhatls171356	enhancer	E2157	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098231	0.48444		TSPYL5	chr8	97273487	97277928	3761	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4212
enhrx-147749	chr7	6035404	6035405	5995773	5995774	7558	hg38	N/A	N/A	N/A	Enhatls157893	enhancer	E2158	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17436	0.48444		PMS2	chr7	5970924	6009122	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	561
enhrx-98093	chr2	192035190	192035191	191170464	191170465	7559	hg38	N/A	enh19097	N/A	Enhatls104949	enhancer	E2159	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05809	0.48444		STAT4	chr2	191029575	191151596	18144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10019
enhrx-58751	chr15	85623752	85623753	85080521	85080522	7560	hg38	N/A	enh96614	N/A	Enhatls63263	enhancer	E2160	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04586	0.48547		PDE8A	chr15	84980439	85139145	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5453
enhrx-91364	chr2	64517266	64517267	64290132	64290133	7561	hg38	N/A	enh18605	N/A	Enhatls97894	enhancer	E2161	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2931	0.48547		PELI1	chr2	64092651	64144420	133326	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3290
enhrx-50196	chr14	60436188	60436189	59969470	59969471	7562	hg38	N/A	enh96518	N/A	Enhatls54155	enhancer	E2162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075052	0.48608		LRRC9	chr14	59919712	60066817	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2153
enhrx-130451	chr5	1772722	1772723	1772607	1772608	7563	hg38	N/A	N/A	N/A	Enhatls139455	enhancer	E2163	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014404	0.48608		MRPL36	chr5	1798384	1801366	18535	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	242
enhrx-113552	chr3	37269817	37269818	37228326	37228327	7564	hg38	N/A	enh20497	N/A	Enhatls121500	enhancer	E2164	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19709	0.48608		GOLGA4	chr3	37243218	37366879	11255	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1681
enhrx-57460	chr15	71804945	71804946	71512606	71512607	7565	hg38	N/A	enh3706	N/A	Enhatls61824	enhancer	E2165	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0055555	0.48791		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4162
enhrx-145001	chr6	129577153	129577154	129256008	129256009	7566	hg38	N/A	N/A	N/A	Enhatls154951	enhancer	E2166	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10974	0.48802		LAMA2	chr6	128883137	129516566	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6589
enhrx-27875	chr11	34662050	34662051	34640503	34640504	7567	hg38	N/A	enh13887	N/A	Enhatls30334	enhancer	E2167	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031979	0.48802		EHF	chr11	34621092	34663288	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2544
enhrx-136494	chr5	148532095	148532096	149152532	149152533	7568	hg38	N/A	enh22696	N/A	Enhatls145816	enhancer	E2168	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011611	0.48859		ABLIM3	chr5	149141482	149260542	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6285
enhrx-31750	chr11	82345242	82345243	82634200	82634201	7569	hg38	N/A	enh111782	N/A	Enhatls34498	enhancer	E2169	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019927	0.48859		FAM181B	chr11	82729939	82733864	93607	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6419
enhrx-132397	chr5	60682119	60682120	61386292	61386293	7570	hg38	N/A	enh110206	N/A	Enhatls141491	enhancer	E2170	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024726	0.48976		ZSWIM6	chr5	61332257	61546172	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2188
enhrx-137593	chr5	171335796	171335797	171908792	171908793	7571	hg38	N/A	N/A	N/A	Enhatls147043	enhancer	E2171	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020249	0.48976		FBXW11	chr5	171861548	172006873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7384
enhrx-166135	chr9	96193898	96193899	93431616	93431617	7572	hg38	N/A	N/A	N/A	Enhatls177811	enhancer	E2172	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030582	0.48989		FAM120AOS	chr9	93443331	93453581	11429	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3402
enhrx-20676	chr10	70362358	70362359	68602601	68602602	7573	hg38	N/A	enh67540	N/A	Enhatls22767	enhancer	E2173	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16656	0.48989		TET1	chr10	68560336	68694487	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3111
enhrx-146142	chr6	152412548	152412549	152091413	152091414	7574	hg38	N/A	enh39679	N/A	Enhatls156213	enhancer	E2174	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18537	0.49021		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7730
enhrx-93294	chr2	99551713	99551714	98935250	98935251	7575	hg38	N/A	N/A	N/A	Enhatls99924	enhancer	E2175	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027793	0.49021		CRACDL	chr2	98793845	98936259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5220
enhrx-151563	chr7	90248338	90248339	90619024	90619025	7576	hg38	N/A	enh9886	N/A	Enhatls162027	enhancer	E2176	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03485	0.49021		CDK14	chr7	90466423	91210590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4375
enhrx-161904	chr8	134305837	134305838	133293594	133293595	7577	hg38	N/A	enh25340	N/A	Enhatls172941	enhancer	E2177	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037962	0.49188		NDRG1	chr8	133237174	133302022	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5695
enhrx-149032	chr7	33827337	33827338	33787725	33787726	7578	hg38	N/A	N/A	N/A	Enhatls159278	enhancer	E2178	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044692	0.49188		BMPER	chr7	33904910	34156427	116958	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1844
enhrx-50782	chr14	68359406	68359407	67892689	67892690	7579	hg38	N/A	enh51860	N/A	Enhatls54763	enhancer	E2179	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099684	0.49188		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-160691	chr8	102769363	102769364	101757135	101757136	7580	hg38	N/A	enh25186	N/A	Enhatls171641	enhancer	E2180	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0044527	0.49188		NCALD	chr8	101686541	102124907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4482
enhrx-130130	chr4	187514468	187514469	186593314	186593315	7581	hg38	N/A	N/A	N/A	Enhatls139117	enhancer	E2181	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082203	0.49392		FAT1	chr4	186587793	186726722	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7674
enhrx-91460	chr2	67672981	67672982	67445849	67445850	7582	hg38	N/A	enh5612	N/A	Enhatls98009	enhancer	E2182	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10694	0.49392		ETAA1	chr2	67397323	67412089	30505	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3386
enhrx-91410	chr2	65543345	65543346	65316211	65316212	7583	hg38	N/A	enh5604	N/A	Enhatls97951	enhancer	E2184	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18958	0.49392		SPRED2	chr2	65310850	65432637	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3336
enhrx-119575	chr3	141080008	141080009	141361166	141361167	7584	hg38	N/A	enh20992	N/A	Enhatls127946	enhancer	E2185	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023139	0.49448		ZBTB38	chr3	141324212	141449792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7704
enhrx-62551	chr16	27536789	27536790	27525468	27525469	7585	hg38	N/A	enh44273	N/A	Enhatls67208	enhancer	E2186	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070873	0.49511		GTF3C1	chr16	27460612	27549913	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2846
enhrx-165840	chr9	91390672	91390673	88775757	88775758	7586	hg38	N/A	enh25706	N/A	Enhatls177475	enhancer	E2187	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068718	0.49511		NXNL2	chr9	88534032	88575789	195722	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3107
enhrx-120895	chr3	172254543	172254544	172536753	172536754	7587	hg38	N/A	enh36128	N/A	Enhatls129363	enhancer	E2188	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02366	0.4959		TNFSF10	chr3	172505507	172523475	11161	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9024
enhrx-110129	chr22	36748290	36748291	36352245	36352246	7588	hg38	N/A	enh6844	fant61185	Enhatls117853	enhancer	E2189	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067292	0.4959		MYH9	chr22	36281279	36388001	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1960
enhrx-138467	chr6	1044821	1044822	1044586	1044587	7589	hg38	N/A	enh59576	N/A	Enhatls148029	enhancer	E2190	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042984	0.4959		FOXQ1	chr6	1312097	1314758	259938	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	55
enhrx-158448	chr8	41751249	41751250	41893731	41893732	7590	hg38	N/A	N/A	N/A	Enhatls169282	enhancer	E2191	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039308	0.4959		ANK1	chr8	41653219	41896741	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2239
enhrx-30808	chr11	69706540	69706541	69891772	69891773	7591	hg38	N/A	enh50873	N/A	Enhatls33497	enhancer	E2192	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0042388	0.4959		FGF3	chr11	69809967	69819416	70242	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5477
enhrx-73201	chr17	57934789	57934790	59857428	59857429	7592	hg38	hs1619	enh17263	N/A	Enhatls78584	enhancer	E2193	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052144	0.4959		TUBD1	chr17	59859478	59892945	49	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6470
enhrx-121206	chr3	182002816	182002817	182285028	182285029	7593	hg38	N/A	enh71027	N/A	Enhatls129697	enhancer	E2194	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029847	0.4959		ATP11B	chr3	182793502	182921629	504976	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9335
enhrx-59351	chr15	93865158	93865159	93321929	93321930	7594	hg38	N/A	enh16433	fant49413	Enhatls63904	enhancer	E2195	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12001	0.4959		RGMA	chr15	93035270	93089211	232442	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6053
enhrx-34158	chr11	124693587	124693588	124823691	124823692	7595	hg38	N/A	enh14361	N/A	Enhatls37062	enhancer	E2196	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11024	0.4959		MSANTD2	chr11	124766497	124800706	21224	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8827
enhrx-50586	chr14	65546063	65546064	65079345	65079346	7596	hg38	N/A	enh51854	N/A	Enhatls54562	enhancer	E2197	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097381	0.4959		MAX	chr14	65006173	65102695	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2543
enhrx-38860	chr12	54230273	54230274	53836489	53836490	7597	hg38	N/A	enh108536	N/A	Enhatls42043	enhancer	E2198	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013402	0.4959		HOXC13	chr12	53938830	53946544	100360	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-40358	chr12	76178626	76178627	75784846	75784847	7598	hg38	N/A	enh2467	fant42319	Enhatls43628	enhancer	E2199	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011829	0.4959		PHLDA1	chr12	76025446	76031776	240504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5668
enhrx-108507	chr22	19542534	19542535	19555011	19555012	7599	hg38	N/A	enh97216	N/A	Enhatls116039	enhancer	E2200	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11047	0.4959		CLDN5	chr22	19523023	19527545	25318	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	338
enhrx-47609	chr13	110296587	110296588	109644240	109644241	7600	hg38	N/A	enh75390	N/A	Enhatls51412	enhancer	E2201	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054293	0.4959		IRS2	chr13	109752694	109786583	105564	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3231
enhrx-99591	chr2	218550149	218550150	217685426	217685427	7601	hg38	N/A	enh19232	fant10099	Enhatls106554	enhancer	E2202	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.069404	0.4959		TNS1	chr2	217799587	218033982	114009	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11517
enhrx-159016	chr8	59032510	59032511	58119951	58119952	7602	hg38	N/A	enh46581	N/A	Enhatls169862	enhancer	E2203	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051031	0.49626		FAM110B	chr8	57994522	58148788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2807
enhrx-100921	chr2	235584968	235584969	234676324	234676325	7603	hg38	N/A	enh19346	N/A	Enhatls107957	enhancer	E2204	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10132	0.49637		ARL4C	chr2	234493040	234497081	178028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12847
enhrx-6577	chr1	65381786	65381787	64916103	64916104	7604	hg38	N/A	enh11952	fant1855	Enhatls7163	enhancer	E2205	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091203	0.49875		JAK1	chr1	64833228	65067754	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6576
enhrx-104905	chr20	46855591	46855592	48226848	48226849	7605	hg38	N/A	N/A	N/A	Enhatls112171	enhancer	E2206	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15621	0.49875		PREX1	chr20	48624251	48827999	390610	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3333
enhrx-36099	chr12	12972936	12972937	12820002	12820003	7606	hg38	N/A	N/A	N/A	Enhatls39149	enhancer	E2207	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041972	0.49875		DDX47	chr12	12813315	12829981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1409
enhrx-63909	chr16	54928846	54928847	54894934	54894935	7607	hg38	N/A	N/A	N/A	Enhatls68591	enhancer	E2208	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055706	0.49957		IRX5	chr16	54930864	54934485	35857	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4204
enhrx-42820	chr12	116436829	116436830	115999024	115999025	7608	hg38	N/A	enh99041	N/A	Enhatls46240	enhancer	E2209	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035439	0.49957		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8130
enhrx-69637	chr17	27273516	27273517	28946498	28946499	7609	hg38	N/A	enh102563	fant52236	Enhatls74742	enhancer	E2211	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00098804	0.50048		PHF12	chr17	28905249	28951606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2906
enhrx-15108	chr1	209033256	209033257	208859911	208859912	7610	hg38	N/A	N/A	N/A	Enhatls16628	enhancer	E2212	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094567	0.50077		PLXNA2	chr1	208022241	208244384	612047	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15107
enhrx-40951	chr12	94486888	94486889	94093112	94093113	7611	hg38	N/A	enh80349	N/A	Enhatls44266	enhancer	E2213	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1042	0.50109		PLXNC1	chr12	94148576	94307675	53365	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6261
enhrx-49952	chr14	56207359	56207360	55740641	55740642	7612	hg38	N/A	enh75471	N/A	Enhatls53902	enhancer	E2214	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34697	0.50304		KTN1	chr14	55559071	55701526	36602	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1909
enhrx-56746	chr15	63765348	63765349	63473149	63473150	7613	hg38	N/A	enh16225	fant48460	Enhatls61055	enhancer	E2215	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00034793	0.50361		USP3	chr15	63504510	63594640	31254	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3448
enhrx-52355	chr14	94932277	94932278	94465940	94465941	7614	hg38	N/A	N/A	N/A	Enhatls56458	enhancer	E2216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081818	0.50361		SERPINA9	chr14	94462716	94476333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4312
enhrx-105701	chr20	60975063	60975064	62400007	62400008	7615	hg38	N/A	enh90123	N/A	Enhatls113055	enhancer	E2217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096449	0.50636		CABLES2	chr20	62388633	62407285	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4129
enhrx-171970	chrX	39980824	39980825	40121571	40121572	7616	hg38	N/A	enh85647	N/A	Enhatls184013	enhancer	E2218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011257	0.50767		BCOR	chrX	40049814	40177329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1687
enhrx-8078	chr1	95061561	95061562	94596005	94596006	7617	hg38	N/A	enh12075	N/A	Enhatls8748	enhancer	E2219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11284	0.50767		F3	chr1	94529172	94541759	46491	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8077
enhrx-7245	chr1	79756868	79756869	79291183	79291184	7618	hg38	N/A	enh79096	N/A	Enhatls7860	enhancer	E2220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054837	0.50831		ADGRL4	chr1	78889763	79282124	6857	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7244
enhrx-120142	chr3	153068331	153068332	153350542	153350543	7619	hg38	N/A	enh36005	N/A	Enhatls128543	enhancer	E2221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08621	0.50831		RAP2B	chr3	153162225	153170627	176250	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8271
enhrx-77124	chr18	21812161	21812162	24232197	24232198	7620	hg38	N/A	enh32511	N/A	Enhatls82771	enhancer	E2222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097535	0.50865		OSBPL1A	chr18	24162044	24397824	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1142
enhrx-112657	chr3	14290816	14290817	14249316	14249317	7621	hg38	N/A	enh20365	N/A	Enhatls120552	enhancer	E2223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13225	0.50865		LSM3	chr3	14178816	14201122	45118	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	786
enhrx-27922	chr11	35387608	35387609	35366061	35366062	7622	hg38	N/A	enh28756	N/A	Enhatls30391	enhancer	E2224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10118	0.50865		SLC1A2	chr11	35251204	35420063	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2591
enhrx-117702	chr3	113864304	113864305	114145457	114145458	7623	hg38	N/A	enh35778	N/A	Enhatls125967	enhancer	E2225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11071	0.50865		DRD3	chr3	114127579	114199407	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5831
enhrx-65837	chr16	78032452	78032453	77998555	77998556	7624	hg38	N/A	enh96708	N/A	Enhatls70648	enhancer	E2226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10627	0.50865		VAT1L	chr16	77788563	77980107	16362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6132
enhrx-119535	chr3	139966835	139966836	140247993	140247994	7625	hg38	N/A	enh35917	N/A	Enhatls127906	enhancer	E2227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020859	0.50865		CLSTN2	chr3	139935184	140577397	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7664
enhrx-137593	chr5	171381608	171381609	171954604	171954605	7626	hg38	N/A	enh8875	N/A	Enhatls147045	enhancer	E2228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048823	0.50865		FBXW11	chr5	171861548	172006873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7384
enhrx-133651	chr5	80971849	80971850	81676030	81676031	7627	hg38	N/A	enh8545	N/A	Enhatls142779	enhancer	E2229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061407	0.50865		SSBP2	chr5	81412803	81751250	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3442
enhrx-150356	chr7	69460120	69460121	69995134	69995135	7628	hg38	N/A	N/A	N/A	Enhatls160732	enhancer	E2230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075231	0.50866		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3168
enhrx-17483	chr1	247887077	247887078	247723775	247723776	7629	hg38	N/A	N/A	N/A	Enhatls19109	enhancer	E2231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17447	0.50866		OR14A2	chr1	247722956	247748141	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17482
enhrx-17483	chr1	247887077	247887078	247723775	247723776	7630	hg38	N/A	N/A	N/A	Enhatls19109	enhancer	E2231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17447	0.50866		OR14K1	chr1	247738614	247739559	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17482
enhrx-170858	chrX	12759680	12759681	12741561	12741562	7631	hg38	N/A	enh85577	N/A	Enhatls182830	enhancer	E2232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000872	0.50866		FRMPD4	chrX	11822422	12724523	14944	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	575
enhrx-157844	chr8	29098242	29098243	29240725	29240726	7632	hg38	N/A	enh110426	N/A	Enhatls168622	enhancer	E2233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011613	0.50866		KIF13B	chr8	29067277	29263097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1635
enhrx-175441	chrX	108621153	108621154	109377924	109377925	7633	hg38	N/A	N/A	N/A	Enhatls187628	enhancer	E2234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055242	0.50866		GUCY2F	chrX	109372905	109482086	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5158
enhrx-130713	chr5	10467462	10467463	10467350	10467351	7634	hg38	N/A	enh37596	N/A	Enhatls139724	enhancer	E2235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015786	0.50866		ROPN1L	chr5	10441523	10465026	231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	504
enhrx-94919	chr2	129886885	129886886	129129312	129129313	7635	hg38	N/A	enh62843	N/A	Enhatls101631	enhancer	E2236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0091465	0.50866		HS6ST1	chr2	128265479	128318868	808345	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6845
enhrx-23796	chr10	113152139	113152140	111392381	111392382	7636	hg38	N/A	enh95419	N/A	Enhatls26118	enhancer	E2237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13881	0.50866		ADRA2A	chr10	111077028	111080907	309301	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6231
enhrx-15604	chr1	219743646	219743647	219570304	219570305	7637	hg38	N/A	N/A	N/A	Enhatls17145	enhancer	E2238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12063	0.50866		ZC3H11B	chr1	219608011	219613105	29849	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15603
enhrx-59283	chr15	92115552	92115553	91572322	91572323	7638	hg38	N/A	enh96630	N/A	Enhatls63835	enhancer	E2239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020149	0.5095		SV2B	chr15	91099949	91302565	267611	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5985
enhrx-15735	chr1	221785956	221785957	221612614	221612615	7639	hg38	N/A	enh27551	N/A	Enhatls17274	enhancer	E2240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065993	0.5095		DUSP10	chr1	221701423	221742089	86424	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15734
enhrx-130686	chr5	10331792	10331793	10331680	10331681	7640	hg38	N/A	enh37594	N/A	Enhatls139696	enhancer	E2241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16709	0.50979		CMBL	chr5	10277594	10307902	6063	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	477
enhrx-139170	chr6	18494046	18494047	18493815	18493816	7641	hg38	N/A	enh38866	N/A	Enhatls148781	enhancer	E2242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035062	0.50979		RNF144B	chr6	18387349	18468870	17745	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	758
enhrx-95180	chr2	134432043	134432044	133674472	133674473	7642	hg38	N/A	enh65332	N/A	Enhatls101913	enhancer	E2243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024298	0.50979		NCKAP5	chr2	132671787	133568463	103912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7106
enhrx-28593	chr11	48063623	48063624	48042071	48042072	7643	hg38	N/A	enh1781	N/A	Enhatls31101	enhancer	E2244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024039	0.51033		PTPRJ	chr11	47980424	48170839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3262
enhrx-10133	chr1	150489270	150489271	150516794	150516795	7644	hg38	N/A	enh98525	N/A	Enhatls11334	enhancer	E2245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11603	0.51033		ECM1	chr1	150508075	150513789	2276	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10132
enhrx-162832	chr9	1029021	1029022	1029021	1029022	7645	hg38	N/A	N/A	N/A	Enhatls173899	enhancer	E2246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032306	0.51099		DMRT2	chr9	1049857	1057552	6718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	99
enhrx-11029	chr1	155879856	155879857	155910065	155910066	7646	hg38	N/A	N/A	N/A	Enhatls12264	enhancer	E2247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0079291	0.51154		RIT1	chr1	155897807	155911404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11028
enhrx-134851	chr5	119214650	119214651	119878955	119878956	7647	hg38	N/A	enh83942	N/A	Enhatls144048	enhancer	E2248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025611	0.51154		FAM170A	chr5	119629557	119635822	235909	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4642
enhrx-105572	chr20	60680204	60680205	62105148	62105149	7648	hg38	N/A	enh99882	N/A	Enhatls112917	enhancer	E2249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1475	0.51248		LSM14B	chr20	62122460	62135374	14222	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4000
enhrx-7437	chr1	85763721	85763722	85298038	85298039	7649	hg38	N/A	enh455	fant2184	Enhatls8061	enhancer	E2250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10575	0.51385		DDAH1	chr1	85318480	85578363	20318	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7436
enhrx-145909	chr6	147182303	147182304	146861167	146861168	7650	hg38	N/A	N/A	N/A	Enhatls155957	enhancer	E2251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025105	0.51405		ADGB	chr6	146598969	146815462	45283	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-106649	chr21	31781342	31781343	30409024	30409025	7651	hg38	N/A	enh88646	N/A	Enhatls114032	enhancer	E2252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0082399	0.51427		KRTAP13-1	chr21	30396030	30396822	10126	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	532
enhrx-61284	chr16	14383754	14383755	14289897	14289898	7652	hg38	N/A	N/A	N/A	Enhatls65874	enhancer	E2253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097791	0.51427		MRTFB	chr16	14071318	14266773	22826	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1579
enhrx-14696	chr1	205244443	205244444	205275315	205275316	7653	hg38	N/A	enh893	N/A	Enhatls16183	enhancer	E2254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14626	0.51427		TMCC2	chr1	205227945	205273343	1179	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14695
enhrx-145805	chr6	145062985	145062986	144741849	144741850	7654	hg38	N/A	N/A	N/A	Enhatls155850	enhancer	E2255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10732	0.51462		UTRN	chr6	144285334	144853034	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7393
enhrx-31690	chr11	78251365	78251366	78540319	78540320	7655	hg38	N/A	enh1915	N/A	Enhatls34437	enhancer	E2256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12227	0.51477		NARS2	chr11	78435967	78574874	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6359
enhrx-23688	chr10	111410186	111410187	109650428	109650429	7656	hg38	N/A	enh96141	N/A	Enhatls26002	enhancer	E2257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058497	0.51477		XPNPEP1	chr10	109864765	109923553	212269	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6123
enhrx-133087	chr5	73536874	73536875	74241049	74241050	7657	hg38	N/A	enh22350	N/A	Enhatls142204	enhancer	E2258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094289	0.51777		ARHGEF28	chr5	73626157	73941993	293888	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2878
enhrx-8555	chr1	108479349	108479350	107936727	107936728	7658	hg38	N/A	enh548	N/A	Enhatls9238	enhancer	E2259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08507	0.51777		VAV3	chr1	107571160	107965180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8554
enhrx-133087	chr5	73359836	73359837	74064011	74064012	7659	hg38	N/A	enh37970	N/A	Enhatls142204	enhancer	E2260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044473	0.51785		ARHGEF28	chr5	73626157	73941993	119448	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2878
enhrx-137291	chr5	161683876	161683877	162256870	162256871	7660	hg38	N/A	N/A	N/A	Enhatls146717	enhancer	E2261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038969	0.51785		GABRG2	chr5	162000056	162162977	49713	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7082
enhrx-80705	chr19	7714404	7714405	7649518	7649519	7661	hg38	N/A	N/A	fant56136	Enhatls86569	enhancer	E2262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18477	0.51785		STXBP2	chr19	7637104	7647873	1598	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1675
enhrx-57408	chr15	70800358	70800359	70508019	70508020	7662	hg38	N/A	enh3703	N/A	Enhatls61772	enhancer	E2263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040778	0.51991		UACA	chr15	70654553	70763558	145348	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-16575	chr1	232557129	232557130	232421383	232421384	7663	hg38	N/A	enh58226	N/A	Enhatls18165	enhancer	E2264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12704	0.51991		SIPA1L2	chr1	232397964	232630516	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16574
enhrx-119535	chr3	139926542	139926543	140207700	140207701	7664	hg38	N/A	enh70862	N/A	Enhatls127906	enhancer	E2265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044779	0.51992		CLSTN2	chr3	139935184	140577397	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7664
enhrx-37149	chr12	32453428	32453429	32300494	32300495	7665	hg38	N/A	enh2262	N/A	Enhatls40257	enhancer	E2266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10677	0.52038		BICD1	chr12	32106834	32383633	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2459
enhrx-158841	chr8	53379725	53379726	52467165	52467166	7666	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	E2267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13716	0.52038		ALKAL1	chr8	52534036	52565430	17492	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2632
enhrx-111585	chr22	50446582	50446583	50008153	50008154	7667	hg38	N/A	enh53972	N/A	Enhatls119424	enhancer	E2268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0049659	0.52038		IL17REL	chr22	49991810	50012765	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3416
enhrx-141681	chr6	44636850	44636851	44669113	44669114	7668	hg38	N/A	enh23263	N/A	Enhatls151477	enhancer	E2269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11861	0.52039		SUPT3H	chr6	44826725	45377934	143965	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3269
enhrx-106748	chr21	33720793	33720794	32348484	32348485	7669	hg38	N/A	N/A	N/A	Enhatls114137	enhancer	E2270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14512	0.52039		URB1	chr21	32311017	32393012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	631
enhrx-125976	chr4	77612220	77612221	76691067	76691068	7670	hg38	N/A	N/A	N/A	Enhatls134772	enhancer	E2271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10538	0.52039		SHROOM3	chr4	76435228	76783253	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3520
enhrx-113994	chr3	42621289	42621290	42579797	42579798	7671	hg38	N/A	N/A	N/A	Enhatls121989	enhancer	E2272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13767	0.52121		SEC22C	chr3	42547968	42601080	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2123
enhrx-17673	chr10	1769309	1769310	1727115	1727116	7672	hg38	N/A	N/A	N/A	Enhatls19310	enhancer	E2273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16266	0.52225		ADARB2	chr10	1177312	1737525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	108
enhrx-85577	chr19	45353892	45353893	44850635	44850636	7673	hg38	N/A	enh18099	N/A	Enhatls91718	enhancer	E2274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01264	0.52225		NECTIN2	chr19	44846174	44889223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6547
enhrx-62557	chr16	27608835	27608836	27597514	27597515	7674	hg38	N/A	enh88233	N/A	Enhatls67214	enhancer	E2275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041666	0.52418		KATNIP	chr16	27550143	27780344	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2852
enhrx-88410	chr2	9970660	9970661	9830531	9830532	7675	hg38	N/A	enh18252	N/A	Enhatls94709	enhancer	E2276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14864	0.52418		TAF1B	chr2	9843442	9934416	8557	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	336
enhrx-103162	chr20	30267886	30267887	31680083	31680084	7676	hg38	N/A	enh6337	N/A	Enhatls110296	enhancer	E2277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053857	0.52432		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-102493	chr20	15042816	15042817	15062170	15062171	7677	hg38	N/A	enh19498	N/A	Enhatls109591	enhancer	E2278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29439	0.52449		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	921
enhrx-47223	chr13	99068777	99068778	98416523	98416524	7678	hg38	N/A	enh15435	N/A	Enhatls50990	enhancer	E2279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0339	0.52449		FARP1	chr13	98142561	98455176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-96888	chr2	171500119	171500120	170643609	170643610	7679	hg38	N/A	enh97008	N/A	Enhatls103707	enhancer	E2280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041515	0.52449		MYO3B	chr2	170178144	170655167	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8814
enhrx-152055	chr7	97945070	97945071	98315758	98315759	7680	hg38	N/A	N/A	N/A	Enhatls162523	enhancer	E2281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11097	0.52449		BAIAP2L1	chr7	98291649	98401090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4867
enhrx-135608	chr5	135057563	135057564	135721874	135721875	7681	hg38	N/A	N/A	N/A	Enhatls144876	enhancer	E2282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0072555	0.52449		SLC25A48	chr5	135579201	135889770	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5399
enhrx-148676	chr7	27386639	27386640	27347020	27347021	7682	hg38	N/A	enh57965	N/A	Enhatls158890	enhancer	E2283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096401	0.52449		EVX1	chr7	27242699	27247830	99125	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1488
enhrx-128118	chr4	124446576	124446577	123525421	123525422	7683	hg38	N/A	enh54968	N/A	Enhatls136991	enhancer	E2284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10758	0.52563		SPRY1	chr4	123396794	123403760	119171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5662
enhrx-73810	chr17	63664427	63664428	65668309	65668310	7684	hg38	N/A	N/A	N/A	Enhatls79237	enhancer	E2285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060894	0.52565		CEP112	chr17	65635536	66192133	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7079
enhrx-147997	chr7	10062828	10062829	10023201	10023202	7685	hg38	N/A	N/A	N/A	Enhatls158161	enhancer	E2286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.007209	0.52679		NDUFA4	chr7	10931942	10940153	812125	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	809
enhrx-166233	chr9	97648293	97648294	94886011	94886012	7686	hg38	N/A	enh10843	N/A	Enhatls177916	enhancer	E2287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14009	0.52679		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3500
enhrx-8539	chr1	108186525	108186526	107643903	107643904	7687	hg38	N/A	N/A	N/A	Enhatls9221	enhancer	E2288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11018	0.52679		VAV3	chr1	107571160	107965180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8538
enhrx-105053	chr20	48175841	48175842	49559304	49559305	7688	hg38	N/A	enh34676	N/A	Enhatls112327	enhancer	E2289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033816	0.52711		PTGIS	chr20	49503873	49568137	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3481
enhrx-106973	chr21	35426796	35426797	34054496	34054497	7689	hg38	N/A	enh53853	N/A	Enhatls114372	enhancer	E2290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049997	0.52711		MRPS6	chr21	34073577	34143030	15723	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	856
enhrx-106973	chr21	35426796	35426797	34054496	34054497	7690	hg38	N/A	enh53853	N/A	Enhatls114372	enhancer	E2290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049997	0.52711		SLC5A3	chr21	34073577	34106260	15723	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	856
enhrx-169514	chr9	137178643	137178644	134286797	134286798	7691	hg38	N/A	enh66755	N/A	N/A	enhancer	E2291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11769	0.52711		RXRA	chr9	134326454	134440585	35153	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6781
enhrx-130529	chr5	5650554	5650555	5650441	5650442	7692	hg38	N/A	N/A	N/A	Enhatls139535	enhancer	E2292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09433	0.52711		ICE1	chr5	5420663	5490220	157943	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	320
enhrx-69456	chr17	26200963	26200964	27873937	27873938	7693	hg38	N/A	enh17067	N/A	Enhatls74562	enhancer	E2293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074879	0.5277		LYRM9	chr17	27878313	27893383	2225	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2725
enhrx-89580	chr2	28976362	28976363	28753496	28753497	7694	hg38	N/A	enh18397	fant6416	Enhatls95961	enhancer	E2294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096676	0.5277		PPP1CB	chr2	28751639	28802940	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1506
enhrx-112102	chr3	8297646	8297647	8255959	8255960	7695	hg38	N/A	enh76864	N/A	Enhatls119959	enhancer	E2295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092628	0.52771		LMCD1	chr3	8501806	8574668	241469	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	231
enhrx-80598	chr19	7490107	7490108	7425221	7425222	7696	hg38	N/A	enh17893	N/A	Enhatls86459	enhancer	E2296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12724	0.52771		ARHGEF18	chr19	7348936	7472485	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1568
enhrx-58567	chr15	83611493	83611494	82942741	82942742	7697	hg38	N/A	enh44175	N/A	Enhatls63068	enhancer	E2297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091572	0.52839		HOMER2	chr15	82836945	82952728	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5269
enhrx-16123	chr1	226890727	226890728	226703026	226703027	7698	hg38	N/A	enh973	N/A	Enhatls17705	enhancer	E2298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042204	0.52839		ITPKB	chr1	226631689	226739323	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16122
enhrx-154663	chr7	137649245	137649246	137964499	137964500	7699	hg38	N/A	enh24560	N/A	Enhatls165287	enhancer	E2299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10165	0.52856		CREB3L2	chr7	137874978	138002086	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7475
enhrx-22044	chr10	92473011	92473012	90713254	90713255	7700	hg38	N/A	N/A	N/A	Enhatls24253	enhancer	E2300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14656	0.52941		HTR7	chr10	90740822	90858039	19226	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4479
enhrx-148676	chr7	27464025	27464026	27424406	27424407	7701	hg38	N/A	enh84582	N/A	Enhatls158890	enhancer	E2301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10427	0.52941		HIBADH	chr7	27525441	27662883	98466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1488
enhrx-131148	chr5	32224269	32224270	32224163	32224164	7702	hg38	N/A	enh22103	N/A	Enhatls140178	enhancer	E2302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062942	0.52941		MTMR12	chr5	32226993	32312969	159	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	939
enhrx-24260	chr10	120003578	120003579	118244066	118244067	7703	hg38	N/A	enh98753	N/A	Enhatls26613	enhancer	E2303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060383	0.52941		FAM204A	chr10	118297924	118342324	52542	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6695
enhrx-26289	chr11	7554616	7554617	7533385	7533386	7704	hg38	N/A	enh1624	N/A	Enhatls28653	enhancer	E2304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16486	0.52941		PPFIBP2	chr11	7513297	7657078	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	958
enhrx-72386	chr17	47184264	47184265	49106902	49106903	7705	hg38	N/A	enh17201	N/A	Enhatls77696	enhancer	E2305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18919	0.52941		B4GALNT2	chr17	49132459	49176840	18287	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5655
enhrx-135130	chr5	127652956	127652957	128317264	128317265	7706	hg38	N/A	enh59538	N/A	Enhatls144351	enhancer	E2306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05959	0.52941		FBN2	chr5	128257908	128659185	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4921
enhrx-113843	chr3	39219000	39219001	39177509	39177510	7707	hg38	N/A	enh20508	N/A	Enhatls121827	enhancer	E2307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15801	0.52941		XIRP1	chr3	39183209	39192596	2602	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1972
enhrx-49189	chr14	37067187	37067188	36597982	36597983	7708	hg38	N/A	N/A	N/A	Enhatls53090	enhancer	E2308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044368	0.52941		NKX2-8	chr14	36580003	36582614	4972	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1146
enhrx-109970	chr22	32958712	32958713	32562726	32562727	7709	hg38	N/A	enh20148	N/A	Enhatls117675	enhancer	E2309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05255	0.52941		SYN3	chr22	32507819	33058381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1801
enhrx-167477	chr9	116882854	116882855	114120574	114120575	7710	hg38	N/A	enh25927	N/A	Enhatls179240	enhancer	E2310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1276	0.53029		KIF12	chr9	114086125	114099292	14315	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4744
enhrx-132073	chr5	54177748	54177749	54881920	54881921	7711	hg38	N/A	enh45846	N/A	Enhatls141157	enhancer	E2311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12632	0.53186		ESM1	chr5	54977866	55022671	91745	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1864
enhrx-5028	chr1	44470456	44470457	44004784	44004785	7712	hg38	N/A	enh61832	N/A	Enhatls5516	enhancer	E2312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11149	0.53186		SLC6A9	chr1	43991499	44031462	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5027
enhrx-61606	chr16	17398495	17398496	17304638	17304639	7713	hg38	N/A	enh3921	N/A	Enhatls66215	enhancer	E2313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071521	0.53201		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-16681	chr1	234860017	234860018	234724270	234724271	7714	hg38	N/A	enh12795	N/A	Enhatls18289	enhancer	E2314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079181	0.53303		IRF2BP2	chr1	234604268	234610178	113495	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-102384	chr20	10781158	10781159	10800510	10800511	7715	hg38	N/A	enh59056	N/A	Enhatls109471	enhancer	E2315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15732	0.53303		JAG1	chr20	10637683	10673999	119519	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	812
enhrx-135963	chr5	139703151	139703152	140323566	140323567	7716	hg38	N/A	enh22636	N/A	Enhatls145252	enhancer	E2316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12739	0.53326		HBEGF	chr5	140332842	140346603	8170	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5754
enhrx-66233	chr16	85753941	85753942	85720335	85720336	7717	hg38	N/A	enh16876	N/A	Enhatls71103	enhancer	E2317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10976	0.53326		C16orf74	chr16	85690169	85751129	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6528
enhrx-16054	chr1	226063317	226063318	225875617	225875618	7718	hg38	N/A	N/A	N/A	Enhatls17624	enhancer	E2318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090857	0.5337		TMEM63A	chr1	225845535	225882380	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16053
enhrx-167400	chr9	116114500	116114501	113352220	113352221	7719	hg38	N/A	N/A	N/A	Enhatls179152	enhancer	E2319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19869	0.5337		BSPRY	chr9	113349540	113371222	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4667
enhrx-49849	chr14	55174234	55174235	54707516	54707517	7720	hg38	N/A	N/A	N/A	Enhatls53783	enhancer	E2320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082585	0.5337		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1806
enhrx-93694	chr2	106163186	106163187	105546729	105546730	7721	hg38	N/A	enh48320	N/A	Enhatls100340	enhancer	E2321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055987	0.5337		FHL2	chr2	105357711	105438513	97120	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5620
enhrx-8047	chr1	94798993	94798994	94333437	94333438	7722	hg38	N/A	enh12071	N/A	Enhatls8718	enhancer	E2322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054803	0.5337		ABCD3	chr1	94418388	94518663	70770	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8046
enhrx-140542	chr6	34512867	34512868	34545090	34545091	7723	hg38	N/A	enh63528	fant22321	Enhatls150247	enhancer	E2323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12992	0.5337		SPDEF	chr6	34537801	34556333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2130
enhrx-104943	chr20	47481464	47481465	48864927	48864928	7724	hg38	N/A	enh87192	N/A	Enhatls112214	enhancer	E2324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017792	0.5337		PREX1	chr20	48624251	48827999	30372	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3371
enhrx-42835	chr12	116737569	116737570	116299764	116299765	7725	hg38	N/A	enh51417	N/A	Enhatls46255	enhancer	E2325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12505	0.5337		MED13L	chr12	115958575	116277693	14048	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-103162	chr20	30307766	30307767	31719963	31719964	7726	hg38	N/A	N/A	fant58371	Enhatls110296	enhancer	E2326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017245	0.5337		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-160945	chr8	109620879	109620880	108608650	108608651	7727	hg38	N/A	N/A	N/A	Enhatls171898	enhancer	E2327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057039	0.5337		EMC2	chr8	108443600	108489196	113251	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4736
enhrx-6900	chr1	71333563	71333564	70867880	70867881	7728	hg38	N/A	N/A	N/A	Enhatls7508	enhancer	E2328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080104	0.5337		PTGER3	chr1	70852352	71047816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6899
enhrx-132237	chr5	55718283	55718284	56422456	56422457	7729	hg38	N/A	enh22245	N/A	Enhatls141322	enhancer	E2329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057033	0.53389		ANKRD55	chr5	56099679	56233330	189015	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-102704	chr20	19512260	19512261	19531616	19531617	7730	hg38	N/A	enh45102	N/A	Enhatls109818	enhancer	E2330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058002	0.53389		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1132
enhrx-28128	chr11	44611001	44611002	44589451	44589452	7731	hg38	N/A	enh1732	N/A	Enhatls30608	enhancer	E2331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19621	0.53389		CD82	chr11	44564426	44620358	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2797
enhrx-21531	chr10	81140217	81140218	79380461	79380462	7732	hg38	N/A	enh28279	fant36320	Enhatls23704	enhancer	E2332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039957	0.53389		ZCCHC24	chr10	79382324	79445624	1758	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3966
enhrx-102165	chr20	5826830	5826831	5846184	5846185	7733	hg38	N/A	enh76627	fant57894	Enhatls109234	enhancer	E2333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085726	0.53475		SHLD1	chr20	5750392	5864395	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	593
enhrx-88252	chr2	5251943	5251944	5111810	5111811	7734	hg38	N/A	enh96859	N/A	Enhatls94509	enhancer	E2334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014157	0.53573		SOX11	chr2	5692383	5701385	578522	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	178
enhrx-160771	chr8	103915377	103915378	102903149	102903150	7735	hg38	N/A	enh25206	N/A	Enhatls171724	enhancer	E2335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011972	0.53584		AZIN1	chr8	102826110	102872412	26646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4562
enhrx-134453	chr5	109238486	109238487	109902785	109902786	7736	hg38	N/A	enh38233	N/A	Enhatls143623	enhancer	E2336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045746	0.53584		MAN2A1	chr5	109689926	109869625	27000	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4244
enhrx-161648	chr8	129099670	129099671	128087424	128087425	7737	hg38	N/A	enh10535	N/A	Enhatls172661	enhancer	E2337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042406	0.53584		MYC	chr8	127735433	127742951	338294	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5439
enhrx-70179	chr17	33414554	33414555	35087535	35087536	7738	hg38	N/A	N/A	N/A	Enhatls75312	enhancer	E2338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072721	0.53584		RFFL	chr17	35005989	35089319	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3448
enhrx-43822	chr12	124647178	124647179	124162632	124162633	7739	hg38	N/A	N/A	N/A	Enhatls47303	enhancer	E2339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0051765	0.53584		RFLNA	chr12	123973240	124316024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9132
enhrx-166301	chr9	98955955	98955956	96193673	96193674	7740	hg38	N/A	N/A	N/A	Enhatls177997	enhancer	E2340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30264	0.53584		HSD17B3	chr9	96235305	96302176	27691	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3568
enhrx-11952	chr1	162129419	162129420	162159629	162159630	7741	hg38	N/A	enh74390	fant3476	Enhatls13243	enhancer	E2341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024127	0.536		NOS1AP	chr1	162069690	162370475	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11951
enhrx-137676	chr5	173146878	173146879	173719875	173719876	7742	hg38	N/A	enh8884	N/A	Enhatls147147	enhancer	E2342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0031609	0.536		BOD1	chr5	173607144	173616653	95295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7467
enhrx-50835	chr14	69852588	69852589	69385871	69385872	7743	hg38	N/A	N/A	N/A	Enhatls54827	enhancer	E2343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024064	0.53611		ERH	chr14	69380127	69398299	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2792
enhrx-146529	chr6	159202546	159202547	158781514	158781515	7744	hg38	N/A	enh23833	N/A	Enhatls156630	enhancer	E2344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043743	0.53611		EZR	chr6	158765740	158819368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8117
enhrx-42208	chr12	110313458	110313459	109875653	109875654	7745	hg38	N/A	enh14985	N/A	Enhatls45597	enhancer	E2345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067885	0.53611		GLTP	chr12	109850944	109880541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7518
enhrx-5050	chr1	44699478	44699479	44233806	44233807	7746	hg38	N/A	N/A	N/A	Enhatls5539	enhancer	E2346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040988	0.53611		ERI3	chr1	44221069	44355260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5049
enhrx-103264	chr20	30828164	30828165	32240361	32240362	7747	hg38	N/A	N/A	N/A	Enhatls110398	enhancer	E2347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050329	0.53742		POFUT1	chr20	32207879	32238658	10	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1692
enhrx-68777	chr17	16959660	16959661	17056346	17056347	7748	hg38	N/A	N/A	N/A	Enhatls73798	enhancer	E2348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11895	0.53742		MPRIP	chr17	17042456	17217679	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2046
enhrx-127393	chr4	108974754	108974755	108053598	108053599	7749	hg38	N/A	enh54910	N/A	Enhatls136253	enhancer	E2349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033574	0.53742		LEF1	chr4	108047544	108168956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-166961	chr9	111472428	111472429	108710148	108710149	7750	hg38	N/A	enh98288	N/A	Enhatls178703	enhancer	E2350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060232	0.53742		ACTL7B	chr9	108854587	108855986	141933	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-137137	chr5	157603317	157603318	158176309	158176310	7751	hg38	N/A	enh66113	N/A	Enhatls146546	enhancer	E2351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095959	0.53742		CLINT1	chr5	157785742	157859145	312770	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6928
enhrx-148452	chr7	22481953	22481954	22442334	22442335	7752	hg38	N/A	enh9645	N/A	Enhatls158645	enhancer	E2352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041083	0.53751		STEAP1B	chr7	22419443	22632925	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1264
enhrx-107317	chr21	41356764	41356765	39984837	39984838	7753	hg38	N/A	N/A	N/A	Enhatls114763	enhancer	E2353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098532	0.53751		DSCAM	chr21	40010998	40847158	9861	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1200
enhrx-74231	chr17	70702720	70702721	72706581	72706582	7754	hg38	N/A	enh4584	N/A	Enhatls79695	enhancer	E2354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0099231	0.53798		SLC39A11	chr17	72645948	73092712	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7500
enhrx-66351	chr16	88111220	88111221	88077614	88077615	7755	hg38	N/A	N/A	N/A	Enhatls71246	enhancer	E2355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069754	0.53798		BANP	chr16	87950435	88077318	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6646
enhrx-64986	chr16	68450487	68450488	68416584	68416585	7756	hg38	N/A	enh4107	N/A	Enhatls69747	enhancer	E2356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080221	0.53798		SMPD3	chr16	68358326	68448508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5281
enhrx-17616	chr10	773587	773588	727647	727648	7757	hg38	N/A	enh12891	N/A	Enhatls19242	enhancer	E2357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058278	0.53817		DIP2C	chr10	274200	689668	34338	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	51
enhrx-156607	chr8	8953644	8953645	9096134	9096135	7758	hg38	N/A	enh73123	N/A	Enhatls167293	enhancer	E2358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012412	0.53817		ERI1	chr8	9002843	9116746	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	398
enhrx-103242	chr20	30724144	30724145	32136341	32136342	7759	hg38	N/A	N/A	N/A	Enhatls110376	enhancer	E2359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091425	0.5396		TM9SF4	chr20	32109713	32167258	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1670
enhrx-7741	chr1	90836873	90836874	90371315	90371316	7760	hg38	N/A	enh26950	N/A	Enhatls8378	enhancer	E2360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0018375	0.54015		ZNF326	chr1	89995109	90035533	333235	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7740
enhrx-118639	chr3	128104336	128104337	128385493	128385494	7761	hg38	N/A	enh7522	N/A	Enhatls126956	enhancer	E2361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1525	0.54015		EEFSEC	chr3	128153480	128408646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6768
enhrx-141583	chr6	43772520	43772521	43804783	43804784	7762	hg38	N/A	enh23254	N/A	Enhatls151362	enhancer	E2362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086496	0.54015		VEGFA	chr6	43770210	43786487	17956	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3171
enhrx-164089	chr9	34484850	34484851	34484852	34484853	7763	hg38	N/A	N/A	N/A	Enhatls175212	enhancer	E2363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13291	0.54015		DNAI1	chr9	34458751	34520988	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1356
enhrx-142240	chr6	55623544	55623545	55758746	55758747	7764	hg38	N/A	N/A	N/A	Enhatls152063	enhancer	E2364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081017	0.54065		BMP5	chr6	55753652	55875590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3828
enhrx-162817	chr9	709060	709061	709060	709061	7765	hg38	N/A	N/A	N/A	Enhatls173882	enhancer	E2365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039412	0.54065		KANK1	chr9	470290	746105	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	84
enhrx-123969	chr4	30193736	30193737	30192114	30192115	7766	hg38	N/A	N/A	N/A	Enhatls132667	enhancer	E2366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21276	0.54087		PCDH7	chr4	30720368	31146805	514886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1513
enhrx-153791	chr7	122831493	122831494	123191439	123191440	7767	hg38	N/A	N/A	N/A	Enhatls164349	enhancer	E2367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085247	0.54087		SLC13A1	chr7	123113530	123199969	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6603
enhrx-118365	chr3	124642731	124642732	124923884	124923885	7768	hg38	N/A	N/A	N/A	Enhatls126654	enhancer	E2368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068537	0.54087		MUC13	chr3	124905441	124934751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6494
enhrx-96374	chr2	164489126	164489127	163632616	163632617	7769	hg38	N/A	enh18987	N/A	Enhatls103165	enhancer	E2370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18341	0.54087		FIGN	chr2	163593395	163736012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8300
enhrx-47562	chr13	107511952	107511953	106859604	106859605	7770	hg38	N/A	enh15476	N/A	Enhatls51358	enhancer	E2371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051606	0.54087		ARGLU1	chr13	106541672	106568137	288819	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3184
enhrx-18012	chr10	8127038	8127039	8085075	8085076	7771	hg38	N/A	enh12960	N/A	Enhatls19676	enhancer	E2372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017282	0.54213		GATA3	chr10	8045377	8075198	7725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	447
enhrx-9849	chr1	145448976	145448977	145986097	145986098	7772	hg38	N/A	enh603	N/A	Enhatls10744	enhancer	E2373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097633	0.54222		TXNIP	chr1	145992434	145996579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9848
enhrx-113927	chr3	41309714	41309715	41268223	41268224	7773	hg38	N/A	enh20525	N/A	Enhatls121916	enhancer	E2374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067717	0.54228		ULK4	chr3	41246598	41962130	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2056
enhrx-176424	chrX	133804421	133804422	134670391	134670392	7774	hg38	N/A	enh26447	N/A	Enhatls188647	enhancer	E2375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080031	0.54228		PLAC1	chrX	134565837	134658471	5010	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6141
enhrx-27892	chr11	34998907	34998908	34977360	34977361	7775	hg38	N/A	N/A	N/A	Enhatls30355	enhancer	E2376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18807	0.54309		PDHX	chr11	34915828	34996128	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2561
enhrx-39765	chr12	64433564	64433565	64039784	64039785	7776	hg38	N/A	enh51248	N/A	Enhatls42987	enhancer	E2377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1394	0.54433		SRGAP1	chr12	63843760	64162217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5075
enhrx-151968	chr7	96430267	96430268	96800955	96800956	7777	hg38	N/A	N/A	N/A	Enhatls162436	enhancer	E2378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03684	0.54433		SEM1	chr7	96481625	96709861	87203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4780
enhrx-94915	chr2	129557487	129557488	128799913	128799914	7778	hg38	N/A	enh65326	N/A	Enhatls101626	enhancer	E2379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035481	0.54433		HS6ST1	chr2	128265479	128318868	476246	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6841
enhrx-144683	chr6	119457863	119457864	119136698	119136699	7779	hg38	N/A	enh63576	N/A	Enhatls154622	enhancer	E2380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0534	0.54552		FAM184A	chr6	118959762	119149387	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6271
enhrx-126169	chr4	81393013	81393014	80471859	80471860	7780	hg38	N/A	enh97480	fant16188	Enhatls134982	enhancer	E2381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055948	0.54573		CFAP299	chr4	80335729	80963750	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3713
enhrx-129656	chr4	173883910	173883911	172962759	172962760	7781	hg38	N/A	enh55101	N/A	Enhatls138603	enhancer	E2382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13818	0.54573		GALNTL6	chr4	171812253	173041559	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7200
enhrx-50037	chr14	58667519	58667520	58200801	58200802	7782	hg38	N/A	N/A	N/A	Enhatls53992	enhancer	E2383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12501	0.54583		ACTR10	chr14	58200148	58235636	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1994
enhrx-144863	chr6	125789559	125789560	125468413	125468414	7783	hg38	N/A	N/A	N/A	Enhatls154809	enhancer	E2384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00016032	0.54583		HDDC2	chr6	125275349	125302078	147132	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6451
enhrx-44941	chr13	28109646	28109647	27535509	27535510	7784	hg38	N/A	N/A	N/A	Enhatls48485	enhancer	E2385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018238	0.54768		LNX2	chr13	27545912	27620529	10	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	563
enhrx-50822	chr14	69784300	69784301	69317583	69317584	7785	hg38	N/A	enh30997	N/A	Enhatls54814	enhancer	E2386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098357	0.54778		GALNT16	chr14	69259963	69357033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2779
enhrx-95956	chr2	157038829	157038830	156182317	156182318	7786	hg38	N/A	enh53364	fant8997	Enhatls102724	enhancer	E2387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067689	0.54778		NR4A2	chr2	156324436	156342348	141959	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7882
enhrx-6228	chr1	59336202	59336203	58870530	58870531	7787	hg38	N/A	enh49791	N/A	Enhatls6778	enhancer	E2388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090135	0.54778		JUN	chr1	58780790	58784047	84347	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6227
enhrx-84782	chr19	40829800	40829801	40323893	40323894	7788	hg38	N/A	N/A	N/A	Enhatls90884	enhancer	E2389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062186	0.54782		C19orf47	chr19	40319535	40348527	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5752
enhrx-142888	chr6	75913662	75913663	75203946	75203947	7789	hg38	N/A	enh86633	N/A	Enhatls152746	enhancer	E2390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062819	0.5485		COL12A1	chr6	75084325	75206053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4476
enhrx-143307	chr6	86289524	86289525	85579806	85579807	7790	hg38	N/A	N/A	N/A	Enhatls153178	enhancer	E2391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019744	0.54889		SNX14	chr6	85504775	85594156	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4895
enhrx-131434	chr5	36367225	36367226	36367123	36367124	7791	hg38	N/A	enh37734	N/A	Enhatls140485	enhancer	E2392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000255	0.54925		RANBP3L	chr5	36246912	36302114	56222	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1225
enhrx-124344	chr4	41477575	41477576	41475558	41475559	7792	hg38	N/A	enh83044	N/A	Enhatls133067	enhancer	E2393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076466	0.54925		LIMCH1	chr4	41359606	41700044	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1888
enhrx-142067	chr6	52409710	52409711	52544912	52544913	7793	hg38	N/A	enh23303	N/A	Enhatls151882	enhancer	E2394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10624	0.54925		TRAM2	chr6	52497407	52577060	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3655
enhrx-72860	chr17	54466924	54466925	56389563	56389564	7794	hg38	N/A	enh96752	N/A	Enhatls78212	enhancer	E2395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034469	0.55		ANKFN1	chr17	55882300	56517016	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6129
enhrx-12636	chr1	173421352	173421353	173452213	173452214	7795	hg38	N/A	enh61930	N/A	Enhatls13973	enhancer	E2396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058092	0.55		PRDX6	chr1	173477334	173488815	19899	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12635
enhrx-107348	chr21	41723122	41723123	40351195	40351196	7796	hg38	N/A	N/A	N/A	Enhatls114795	enhancer	E2397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086043	0.55		DSCAM	chr21	40010998	40847158	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1231
enhrx-90333	chr2	42075397	42075398	41848257	41848258	7797	hg38	N/A	enh53042	N/A	Enhatls96769	enhancer	E2398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067749	0.55		PKDCC	chr2	42048020	42058517	197646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2259
enhrx-127379	chr4	108815230	108815231	107894074	107894075	7798	hg38	N/A	enh86555	N/A	Enhatls136233	enhancer	E2399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0021786	0.55		SGMS2	chr4	107824562	107915047	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4923
enhrx-66273	chr16	87265048	87265049	87231442	87231443	7799	hg38	N/A	enh32018	N/A	Enhatls71157	enhancer	E2400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27714	0.55		C16orf95	chr16	87302800	87317420	70872	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6568
enhrx-36037	chr12	11837094	11837095	11684160	11684161	7800	hg38	N/A	enh14523	N/A	Enhatls39080	enhancer	E2401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0054543	0.55		ETV6	chr12	11649673	11895377	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1347
enhrx-41817	chr12	106490392	106490393	106096614	106096615	7801	hg38	N/A	enh29957	N/A	Enhatls45188	enhancer	E2402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098314	0.55		NUAK1	chr12	106063344	106138954	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7127
enhrx-65870	chr16	81024765	81024766	80991160	80991161	7802	hg38	N/A	N/A	N/A	Enhatls70694	enhancer	E2403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19959	0.55		CMC2	chr16	80966447	81020270	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6165
enhrx-146424	chr6	158018536	158018537	157597504	157597505	7803	hg38	N/A	enh63616	N/A	Enhatls156509	enhancer	E2404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021769	0.55		ZDHHC14	chr6	157381132	157678157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8012
enhrx-165955	chr9	94547111	94547112	91784829	91784830	7804	hg38	N/A	enh86743	N/A	Enhatls177607	enhancer	E2405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093539	0.55		ROR2	chr9	91563090	91950228	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3222
enhrx-14477	chr1	203180283	203180284	203211155	203211156	7805	hg38	N/A	N/A	N/A	Enhatls15931	enhancer	E2406	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13768	0.55		CHIT1	chr1	203216078	203229673	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14476
enhrx-41240	chr12	99829328	99829329	99435550	99435551	7806	hg38	N/A	enh2554	N/A	Enhatls44574	enhancer	E2407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070695	0.55		ANKS1B	chr12	98734683	99984936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6550
enhrx-27879	chr11	34771933	34771934	34750386	34750387	7807	hg38	N/A	enh43526	N/A	Enhatls30341	enhancer	E2408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1542	0.55		EHF	chr11	34621092	34663288	84491	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2548
enhrx-99516	chr2	216847325	216847326	215982602	215982603	7808	hg38	N/A	enh59020	fant10046	Enhatls106469	enhancer	E2409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029337	0.55004		MREG	chr2	215942583	216034096	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11442
enhrx-33307	chr11	115421199	115421200	115550481	115550482	7809	hg38	N/A	enh87928	N/A	Enhatls36142	enhancer	E2410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15201	0.55004		CADM1	chr11	115169235	115504957	42011	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7976
enhrx-104870	chr20	46093310	46093311	47464566	47464567	7810	hg38	N/A	enh6514	N/A	Enhatls112130	enhancer	E2411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00564	0.55026		NCOA3	chr20	47501886	47656877	26072	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3298
enhrx-70970	chr17	38478740	38478741	40322488	40322489	7811	hg38	N/A	enh4408	N/A	Enhatls76143	enhancer	E2412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062354	0.55026		RARA	chr17	40309179	40357643	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4239
enhrx-132237	chr5	55763276	55763277	56467449	56467450	7812	hg38	N/A	enh22248	N/A	Enhatls141325	enhancer	E2413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.22433	0.55064		ANKRD55	chr5	56099679	56233330	232320	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-65836	chr16	77952882	77952883	77918985	77918986	7813	hg38	N/A	enh64978	N/A	Enhatls70646	enhancer	E2414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.045139	0.55064		VAT1L	chr16	77788563	77980107	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6131
enhrx-138345	chr5	180096422	180096423	180669422	180669423	7814	hg38	N/A	enh46048	N/A	Enhatls147899	enhancer	E2415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10064	0.55079		FLT4	chr5	180601505	180649624	17989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8136
enhrx-21455	chr10	79047703	79047704	77287945	77287946	7815	hg38	N/A	enh13321	N/A	Enhatls23603	enhancer	E2416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025781	0.5519		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-150175	chr7	63744239	63744240	64283861	64283862	7816	hg38	N/A	N/A	N/A	Enhatls160523	enhancer	E2417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027494	0.5519		ZNF736	chr7	64310827	64356634	4173	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2987
enhrx-88795	chr2	19248774	19248775	19049018	19049019	7817	hg38	N/A	enh33122	N/A	Enhatls95132	enhancer	E2418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030355	0.5519		OSR1	chr2	19351484	19358623	300326	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	721
enhrx-32123	chr11	90402486	90402487	90669318	90669319	7818	hg38	N/A	N/A	N/A	Enhatls34891	enhancer	E2419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11469	0.5519		CHORDC1	chr11	90200428	90223077	425451	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6792
enhrx-91829	chr2	72020777	72020778	71793647	71793648	7819	hg38	N/A	enh81718	N/A	Enhatls98397	enhancer	E2420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057806	0.5519		DYSF	chr2	71453560	71686763	104513	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3755
enhrx-39627	chr12	58275394	58275395	57881611	57881612	7820	hg38	N/A	enh75051	N/A	Enhatls42836	enhancer	E2421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092453	0.5519		CTDSP2	chr12	57819926	57846729	32454	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-10149	chr1	150540751	150540752	150568275	150568276	7821	hg38	N/A	enh614	fant3057	Enhatls11351	enhancer	E2422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084272	0.5519		MCL1	chr1	150563101	150579738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10148
enhrx-70856	chr17	37926410	37926411	39770157	39770158	7822	hg38	N/A	enh4402	fant52565	Enhatls76023	enhancer	E2423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013049	0.55246		IKZF3	chr17	39757717	39864312	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4125
enhrx-150049	chr7	55617997	55617998	55550304	55550305	7823	hg38	N/A	enh40205	N/A	Enhatls160395	enhancer	E2424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11521	0.55263		VOPP1	chr7	55470612	55572502	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2861
enhrx-117202	chr3	107700664	107700665	107981817	107981818	7824	hg38	N/A	enh7435	N/A	Enhatls125432	enhancer	E2425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076998	0.55373		CD47	chr3	108043090	108091862	57546	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5331
enhrx-52446	chr14	96589009	96589010	96122672	96122673	7825	hg38	N/A	enh15908	N/A	Enhatls56568	enhancer	E2426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11366	0.55402		C14orf132	chr14	96039361	96093971	21178	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4403
enhrx-4281	chr1	37963653	37963654	37498052	37498053	7826	hg38	N/A	enh26633	N/A	Enhatls4719	enhancer	E2427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083203	0.55409		MEAF6	chr1	37489992	37514766	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4280
enhrx-47081	chr13	95898797	95898798	95246543	95246544	7827	hg38	N/A	N/A	fant44953	Enhatls50839	enhancer	E2428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13065	0.55451		ABCC4	chr13	95019834	95301451	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2703
enhrx-59555	chr15	101272963	101272964	100732758	100732759	7828	hg38	N/A	enh16473	N/A	Enhatls64126	enhancer	E2429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11305	0.55451		ASB7	chr15	100602588	100651701	70644	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6257
enhrx-49848	chr14	55137606	55137607	54670888	54670889	7829	hg38	N/A	enh3200	N/A	Enhatls53782	enhancer	E2430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018791	0.55451		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1805
enhrx-96980	chr2	172421171	172421172	171564661	171564662	7830	hg38	N/A	enh97010	N/A	Enhatls103795	enhancer	E2431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029825	0.55451		CYBRD1	chr2	171522246	171558129	4447	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8906
enhrx-123792	chr4	23328996	23328997	23327373	23327374	7831	hg38	N/A	N/A	N/A	Enhatls132476	enhancer	E2432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013441	0.55451		PPARGC1A	chr4	23792020	23890077	461679	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1336
enhrx-161219	chr8	120221792	120221793	119209552	119209553	7832	hg38	N/A	N/A	N/A	Enhatls172188	enhancer	E2433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13839	0.55453		MAL2	chr8	119165033	119245673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5010
enhrx-15108	chr1	209538273	209538274	209364928	209364929	7833	hg38	N/A	enh27449	fant4615	Enhatls16628	enhancer	E2434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12889	0.55453		CAMK1G	chr1	209583713	209613939	218626	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15107
enhrx-116424	chr3	69320449	69320450	69271298	69271299	7834	hg38	N/A	N/A	N/A	Enhatls124588	enhancer	E2435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057322	0.55453		FRMD4B	chr3	69168781	69542583	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4553
enhrx-16681	chr1	234806896	234806897	234671150	234671151	7835	hg38	N/A	enh87706	N/A	Enhatls18288	enhancer	E2436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1782	0.55453		IRF2BP2	chr1	234604268	234610178	58802	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-125174	chr4	65884168	65884169	65018450	65018451	7836	hg38	N/A	enh101823	N/A	Enhatls133924	enhancer	E2437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044665	0.55453		EPHA5	chr4	65319562	65670495	297846	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2718
enhrx-158051	chr8	37032203	37032204	37174685	37174686	7837	hg38	N/A	enh40913	N/A	Enhatls168859	enhancer	E2438	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13372	0.55453		KCNU1	chr8	36784323	36936125	236523	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-151578	chr7	91225957	91225958	91596642	91596643	7838	hg38	N/A	N/A	N/A	Enhatls162042	enhancer	E2439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03416	0.55453		MTERF1	chr7	91870928	91880702	274007	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4390
enhrx-15464	chr1	215779551	215779552	215606209	215606210	7839	hg38	N/A	N/A	N/A	Enhatls16997	enhancer	E2440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051351	0.55453		KCTD3	chr1	215567303	215621807	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15463
enhrx-73584	chr17	61818125	61818126	63740765	63740766	7840	hg38	N/A	N/A	N/A	Enhatls78985	enhancer	E2441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050401	0.55453		STRADA	chr17	63702818	63741986	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6853
enhrx-42915	chr12	117780708	117780709	117342903	117342904	7841	hg38	N/A	enh58483	N/A	Enhatls46342	enhancer	E2442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10695	0.55461		NOS1	chr12	117208141	117361802	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8225
enhrx-59348	chr15	93606768	93606769	93063539	93063540	7842	hg38	N/A	N/A	N/A	Enhatls63902	enhancer	E2443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05339	0.55516		RGMA	chr15	93035270	93089211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6050
enhrx-23148	chr10	102851819	102851820	101092062	101092063	7843	hg38	N/A	enh79705	N/A	Enhatls25418	enhancer	E2444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063304	0.55516		KAZALD1	chr10	101061988	101067059	23645	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5583
enhrx-145936	chr6	148513208	148513209	148192072	148192073	7844	hg38	N/A	enh23747	N/A	Enhatls155987	enhancer	E2445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11681	0.55575		SASH1	chr6	148342837	148552044	147259	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7524
enhrx-23212	chr10	103653684	103653685	101893927	101893928	7845	hg38	N/A	enh1474	N/A	Enhatls25486	enhancer	E2446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076129	0.55575		ARMH3	chr10	101845598	102056193	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5647
enhrx-17725	chr10	4172259	4172260	4130067	4130068	7846	hg38	N/A	enh1062	N/A	Enhatls19366	enhancer	E2447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092685	0.55575		KLF6	chr10	3775995	3785281	342955	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	160
enhrx-176043	chrX	122913924	122913925	123780074	123780075	7847	hg38	N/A	enh57444	N/A	Enhatls188247	enhancer	E2448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010842	0.55575		THOC2	chrX	123600560	123733056	42780	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5760
enhrx-124301	chr4	40365622	40365623	40363605	40363606	7848	hg38	N/A	enh21462	N/A	Enhatls133021	enhancer	E2449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017531	0.55663		CHRNA9	chr4	40335332	40355217	414	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1845
enhrx-145526	chr6	138580362	138580363	138259225	138259226	7849	hg38	N/A	enh89045	N/A	Enhatls155549	enhancer	E2450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18763	0.55663		ARFGEF3	chr6	138161938	138344663	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7114
enhrx-145199	chr6	132076108	132076109	131754968	131754969	7850	hg38	N/A	enh39495	N/A	Enhatls155155	enhancer	E2451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026118	0.55663		ENPP3	chr6	131628460	131747418	4748	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6787
enhrx-17610	chr10	593008	593009	547068	547069	7851	hg38	N/A	enh12886	N/A	Enhatls19237	enhancer	E2452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046164	0.55663		DIP2C	chr10	274200	689668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	45
enhrx-113447	chr3	34409231	34409232	34367739	34367740	7852	hg38	N/A	N/A	N/A	Enhatls121389	enhancer	E2453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.009996	0.55682		PDCD6IP	chr3	33798570	33869707	496897	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1576
enhrx-159701	chr8	75488905	75488906	74576670	74576671	7853	hg38	N/A	enh98124	N/A	Enhatls170587	enhancer	E2454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034509	0.55682		GDAP1	chr8	74320612	74494697	77574	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3492
enhrx-137324	chr5	164802770	164802771	165375764	165375765	7854	hg38	N/A	N/A	N/A	Enhatls146750	enhancer	E2455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033321	0.55682		TENM2	chr5	166979028	168264157	1585123	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7115
enhrx-31727	chr11	78827843	78827844	79116798	79116799	7855	hg38	N/A	enh14147	N/A	Enhatls34476	enhancer	E2456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076349	0.55682		TENM4	chr11	78652828	79441030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6396
enhrx-76937	chr18	20046658	20046659	22466695	22466696	7856	hg38	N/A	enh17592	N/A	Enhatls82554	enhancer	E2457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0052406	0.55727		CTAGE1	chr18	22413598	22417915	44936	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-120006	chr3	149799916	149799917	150082129	150082130	7857	hg38	N/A	enh7615	N/A	Enhatls128389	enhancer	E2458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13061	0.55727		PFN2	chr3	149964903	150050788	16131	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8135
enhrx-109385	chr22	29320133	29320134	28924145	28924146	7858	hg38	N/A	enh6811	fant60961	Enhatls117056	enhancer	E2459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14975	0.55849		ZNRF3	chr22	28883571	29057488	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1216
enhrx-10798	chr1	154512209	154512210	154539733	154539734	7859	hg38	N/A	N/A	N/A	Enhatls12010	enhancer	E2460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0083209	0.55849		TDRD10	chr1	154502218	154548147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10797
enhrx-146410	chr6	157508771	157508772	157187637	157187638	7860	hg38	N/A	N/A	N/A	Enhatls156494	enhancer	E2461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0090075	0.55849		ARID1B	chr6	156776019	157210779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7998
enhrx-104871	chr20	46196867	46196868	47568123	47568124	7861	hg38	N/A	enh6517	N/A	Enhatls112131	enhancer	E2462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17506	0.55849		NCOA3	chr20	47501886	47656877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3299
enhrx-21516	chr10	81011110	81011111	79251353	79251354	7862	hg38	N/A	enh1382	N/A	Enhatls23682	enhancer	E2463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060356	0.55892		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3951
enhrx-38844	chr12	54052944	54052945	53659160	53659161	7863	hg38	N/A	enh14743	N/A	Enhatls42027	enhancer	E2464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07466	0.55935		ATP5MC2	chr12	53665160	53677408	2125	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4154
enhrx-58093	chr15	77861621	77861622	77569279	77569280	7864	hg38	N/A	enh52107	N/A	Enhatls62497	enhancer	E2465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095065	0.55935		LINGO1	chr15	77613026	77820900	41394	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4795
enhrx-152673	chr7	101151309	101151310	101508028	101508029	7865	hg38	N/A	enh57988	N/A	Enhatls163161	enhancer	E2466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02377	0.55935		COL26A1	chr7	101362874	101559024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5485
enhrx-64011	chr16	56404992	56404993	56371080	56371081	7866	hg38	N/A	enh16684	fant50628	Enhatls68704	enhancer	E2467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11774	0.55935		AMFR	chr16	56361451	56425545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4306
enhrx-161143	chr8	116705935	116705936	115693709	115693710	7867	hg38	N/A	enh98198	N/A	Enhatls172101	enhancer	E2468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0014316	0.55935		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4934
enhrx-78072	chr18	48429345	48429346	50902975	50902976	7868	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	E2469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010185	0.55954		ME2	chr18	50879117	50954257	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2090
enhrx-113078	chr3	25379805	25379806	25338314	25338315	7869	hg38	N/A	enh65605	N/A	N/A	enhancer	E2470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11239	0.55954		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1207
enhrx-57386	chr15	69991654	69991655	69699315	69699316	7870	hg38	N/A	N/A	N/A	Enhatls61747	enhancer	E2471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072916	0.55954		RPLP1	chr15	69452813	69456205	227912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4088
enhrx-19070	chr10	28785527	28785528	28496598	28496599	7871	hg38	N/A	enh13082	N/A	Enhatls20835	enhancer	E2472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0088852	0.56016		WAC	chr10	28532492	28623112	24480	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1505
enhrx-158922	chr8	55826610	55826611	54914050	54914051	7872	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	E2473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11207	0.56016		RP1	chr8	54559168	54871720	27896	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2713
enhrx-13237	chr1	182213758	182213759	182244623	182244624	7873	hg38	N/A	enh12438	N/A	Enhatls14610	enhancer	E2474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22804	0.56016		GLUL	chr1	182378097	182392206	126538	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-146132	chr6	151979359	151979360	151658224	151658225	7874	hg38	N/A	N/A	fant24690	Enhatls156204	enhancer	E2475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01671	0.56037		ESR1	chr6	151690495	152129619	32005	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-52543	chr14	99357681	99357682	98891344	98891345	7875	hg38	N/A	enh51930	N/A	Enhatls56671	enhancer	E2476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1619	0.56037		BCL11B	chr14	99169286	99272197	276049	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4500
enhrx-125852	chr4	76777761	76777762	75856608	75856609	7876	hg38	N/A	N/A	N/A	Enhatls134648	enhancer	E2477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12774	0.56037		PPEF2	chr4	75859866	75902452	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3396
enhrx-58707	chr15	85278452	85278453	84735221	84735222	7877	hg38	N/A	enh3761	N/A	Enhatls63217	enhancer	E2478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036902	0.56078		ZNF592	chr15	84748591	84806445	9844	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5409
enhrx-104630	chr20	44448257	44448258	45819618	45819619	7878	hg38	N/A	enh19659	N/A	Enhatls111890	enhancer	E2479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066357	0.56148		UBE2C	chr20	45812575	45816957	2	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3058
enhrx-116482	chr3	72778250	72778251	72729099	72729100	7879	hg38	N/A	enh20705	N/A	Enhatls124659	enhancer	E2480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065184	0.56164		SHQ1	chr3	72749276	72861914	17873	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-24095	chr10	117413222	117413223	115653712	115653713	7880	hg38	N/A	enh28479	N/A	Enhatls26450	enhancer	E2481	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0059415	0.56164		ATRNL1	chr10	115093364	115948999	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6530
enhrx-21456	chr10	79258819	79258820	77499061	77499062	7881	hg38	N/A	enh1355	N/A	Enhatls23604	enhancer	E2482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03462	0.56164		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-161598	chr8	126079226	126079227	125066984	125066985	7882	hg38	N/A	N/A	N/A	Enhatls172593	enhancer	E2483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022589	0.56198		WASHC5	chr8	125024259	125091792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5389
enhrx-49197	chr14	37170505	37170506	36701300	36701301	7883	hg38	N/A	enh3113	N/A	Enhatls53097	enhancer	E2484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027895	0.56198		SLC25A21	chr14	36677920	37172606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1154
enhrx-52540	chr14	98840748	98840749	98374411	98374412	7884	hg38	N/A	N/A	N/A	Enhatls56668	enhancer	E2485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09693	0.56198		BCL11B	chr14	99169286	99272197	790179	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4497
enhrx-47592	chr13	109571924	109571925	108919576	108919577	7885	hg38	N/A	enh15478	N/A	Enhatls51390	enhancer	E2486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019353	0.56198		MYO16	chr13	108596151	109208005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3214
enhrx-159206	chr8	65179667	65179668	64267110	64267111	7886	hg38	N/A	N/A	N/A	Enhatls170064	enhancer	E2487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064492	0.56198		BHLHE22	chr8	64580364	64583627	310531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2997
enhrx-53659	chr15	26106546	26106547	25861399	25861400	7887	hg38	N/A	N/A	N/A	Enhatls57816	enhancer	E2488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065138	0.56198		ATP10A	chr15	25677272	25865172	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	361
enhrx-174332	chrX	88142120	88142121	88887119	88887120	7888	hg38	N/A	enh98347	N/A	Enhatls186502	enhancer	E2489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0040634	0.56198		CPXCR1	chrX	88747224	88754785	126460	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4049
enhrx-23880	chr10	115235365	115235366	113475606	113475607	7889	hg38	N/A	enh13518	N/A	Enhatls26215	enhancer	E2490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055348	0.56198		HABP2	chr10	113550836	113589602	67541	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6315
enhrx-3116	chr1	26767230	26767231	26440739	26440740	7890	hg38	N/A	N/A	N/A	Enhatls3463	enhancer	E2491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0037298	0.56198		DHDDS	chr1	26432315	26471306	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3115
enhrx-24666	chr10	125381149	125381150	123621633	123621634	7891	hg38	N/A	N/A	N/A	Enhatls27036	enhancer	E2492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018308	0.56204		GPR26	chr10	123666354	123697399	32747	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7101
enhrx-72110	chr17	45051708	45051709	46974342	46974343	7892	hg38	N/A	N/A	N/A	Enhatls77386	enhancer	E2493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0066397	0.56262		GOSR2	chr17	46923074	46975524	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5379
enhrx-148716	chr7	28612993	28612994	28573375	28573376	7893	hg38	N/A	enh9689	N/A	Enhatls158930	enhancer	E2494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016362	0.56262		CREB5	chr7	28299320	28825894	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1528
enhrx-139006	chr6	14492049	14492050	14491818	14491819	7894	hg38	N/A	enh84097	N/A	Enhatls148610	enhancer	E2495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12266	0.56262		CD83	chr6	14117255	14136918	352837	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-120615	chr3	167186114	167186115	167468326	167468327	7895	hg38	N/A	N/A	N/A	Enhatls129052	enhancer	E2496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049656	0.56266		SERPINI2	chr3	167441913	167478972	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8744
enhrx-134970	chr5	123858680	123858681	124522987	124522988	7896	hg38	N/A	enh8638	N/A	Enhatls144176	enhancer	E2497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074184	0.56266		ZNF608	chr5	124636914	124748807	105864	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4761
enhrx-141699	chr6	45441091	45441092	45473354	45473355	7897	hg38	N/A	enh46132	N/A	Enhatls151497	enhancer	E2498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.089901	0.56266		RUNX2	chr6	45328316	45664349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3287
enhrx-80339	chr19	6020818	6020819	6020807	6020808	7898	hg38	N/A	enh48158	N/A	Enhatls86192	enhancer	E2499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037122	0.56384		RFX2	chr19	5993163	6199529	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1309
enhrx-12593	chr1	172329864	172329865	172360724	172360725	7899	hg38	N/A	enh12370	N/A	Enhatls13927	enhancer	E2500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14636	0.56384		DNM3	chr1	171817886	172418466	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12592
enhrx-9437	chr1	117260088	117260089	116717466	116717467	7900	hg38	N/A	enh43034	N/A	Enhatls10197	enhancer	E2501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12826	0.56401		CD2	chr1	116754429	116769229	27439	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9436
enhrx-148142	chr7	15665320	15665321	15625695	15625696	7901	hg38	N/A	N/A	N/A	Enhatls158313	enhancer	E2502	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0084325	0.56401		MEOX2	chr7	15611211	15686683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	954
enhrx-172177	chrX	44557806	44557807	44698560	44698561	7902	hg38	N/A	N/A	N/A	Enhatls184220	enhancer	E2503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11098	0.56401		DUSP21	chrX	44844020	44844888	140062	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1894
enhrx-41809	chr12	105746952	105746953	105353174	105353175	7903	hg38	N/A	N/A	N/A	Enhatls45174	enhancer	E2504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097706	0.56401		C12orf75	chr12	105330635	105396097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7119
enhrx-57984	chr15	76257732	76257733	75965391	75965392	7904	hg38	N/A	enh16339	N/A	Enhatls62382	enhancer	E2505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049548	0.56401		NRG4	chr15	75940935	76059795	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4686
enhrx-92147	chr2	75831628	75831629	75604502	75604503	7905	hg38	N/A	enh18695	N/A	Enhatls98731	enhancer	E2506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035438	0.56401		EVA1A	chr2	75492317	75569722	16272	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7906	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHAC2	chr5	140966469	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7907	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHAC1	chr5	140926298	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7908	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA13	chr5	140882123	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7909	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA12	chr5	140875301	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7910	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA11	chr5	140868182	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7911	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA10	chr5	140855882	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7912	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA9	chr5	140847771	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7913	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA7	chr5	140834247	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7914	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA6	chr5	140827957	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7915	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA5	chr5	140821603	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7916	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA4	chr5	140807036	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7917	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA3	chr5	140801027	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7918	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA2	chr5	140794851	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7919	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA1	chr5	140786135	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-136057	chr5	140367693	140367694	140988108	140988109	7920	hg38	N/A	enh72021	N/A	Enhatls145345	enhancer	E2507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016714	0.56414		PCDHA8	chr5	140841186	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5848
enhrx-85093	chr19	42408763	42408764	41904611	41904612	7921	hg38	N/A	N/A	N/A	Enhatls91220	enhancer	E2508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038972	0.56414		ARHGEF1	chr19	41883183	41930150	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6063
enhrx-5423	chr1	47496875	47496876	47031203	47031204	7922	hg38	N/A	N/A	N/A	Enhatls5938	enhancer	E2509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042467	0.56485		CYP4X1	chr1	47023668	47050751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5422
enhrx-85913	chr19	47274385	47274386	46771128	46771129	7923	hg38	N/A	enh62735	N/A	Enhatls92081	enhancer	E2510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10716	0.56486		SLC1A5	chr19	46774882	46788594	1621	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6883
enhrx-168078	chr9	127483524	127483525	124721245	124721246	7924	hg38	N/A	enh42289	N/A	Enhatls179902	enhancer	E2511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011534	0.56587		NR6A1	chr9	124517274	124771311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5345
enhrx-100927	chr2	236414118	236414119	235505474	235505475	7925	hg38	N/A	enh19364	N/A	Enhatls107964	enhancer	E2512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14909	0.56587		AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12853
enhrx-106294	chr21	16320106	16320107	14947785	14947786	7926	hg38	N/A	enh82297	N/A	Enhatls113648	enhancer	E2513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064829	0.56587		NRIP1	chr21	14961234	15065815	11361	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	177
enhrx-21531	chr10	81118761	81118762	79359005	79359006	7927	hg38	N/A	enh50522	N/A	Enhatls23704	enhancer	E2514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015546	0.56587		PPIF	chr10	79347468	79355334	1556	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3966
enhrx-122822	chr4	2402735	2402736	2401008	2401009	7928	hg38	N/A	enh54560	N/A	Enhatls131427	enhancer	E2515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021511	0.56587		ZFYVE28	chr4	2269581	2418651	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	366
enhrx-66244	chr16	85887095	85887096	85853489	85853490	7929	hg38	N/A	N/A	N/A	Enhatls71114	enhancer	E2516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077884	0.56623		COX4I1	chr16	85798632	85807068	45502	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6539
enhrx-104871	chr20	46205464	46205465	47576720	47576721	7930	hg38	N/A	enh6517	N/A	Enhatls112131	enhancer	E2517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.007661	0.56623		NCOA3	chr20	47501886	47656877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3299
enhrx-157107	chr8	20060937	20060938	20203426	20203427	7931	hg38	N/A	enh24810	N/A	Enhatls167834	enhancer	E2518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086438	0.56623		ATP6V1B2	chr8	20197380	20221696	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	898
enhrx-57447	chr15	71371918	71371919	71079579	71079580	7932	hg38	N/A	enh31484	fant48770	Enhatls61810	enhancer	E2520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062223	0.56623		THSD4	chr15	71096951	71783383	17247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4149
enhrx-125120	chr4	62069109	62069110	61203391	61203392	7933	hg38	N/A	N/A	N/A	Enhatls133867	enhancer	E2521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054977	0.56853		ADGRL3	chr4	61200325	62078335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2664
enhrx-156934	chr8	17187324	17187325	17329815	17329816	7934	hg38	N/A	enh93700	N/A	Enhatls167647	enhancer	E2522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16898	0.56973		MTMR7	chr8	17296793	17413351	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	725
enhrx-75004	chr17	75118083	75118084	77122001	77122002	7935	hg38	N/A	enh17395	fant53867	Enhatls80498	enhancer	E2523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15057	0.56973		SEC14L1	chr17	77088748	77217101	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8273
enhrx-109151	chr22	25362224	25362225	24966257	24966258	7936	hg38	N/A	enh6793	N/A	Enhatls116800	enhancer	E2524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079095	0.57006		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	982
enhrx-82204	chr19	15415082	15415083	15304271	15304272	7937	hg38	N/A	enh5025	N/A	Enhatls88144	enhancer	E2525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10317	0.57016		BRD4	chr19	15235518	15332545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3174
enhrx-36225	chr12	15022169	15022170	14869235	14869236	7938	hg38	N/A	enh80083	N/A	Enhatls39281	enhancer	E2526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056371	0.57099		MGP	chr12	14880863	14885857	9603	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1535
enhrx-148599	chr7	24898147	24898148	24858528	24858529	7939	hg38	N/A	enh93587	N/A	Enhatls158804	enhancer	E2527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0046615	0.57099		OSBPL3	chr7	24796539	24981634	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1411
enhrx-40123	chr12	70326937	70326938	69933157	69933158	7940	hg38	N/A	N/A	N/A	Enhatls43381	enhancer	E2528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0076304	0.57139		MYRFL	chr12	69825226	69959097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5433
enhrx-51884	chr14	89680801	89680802	89214457	89214458	7941	hg38	N/A	enh62427	fant46903	Enhatls55946	enhancer	E2529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030789	0.57139		FOXN3	chr14	89124870	89619149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3841
enhrx-158373	chr8	40248476	40248477	40390957	40390958	7942	hg38	N/A	enh46560	N/A	Enhatls169206	enhancer	E2530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010422	0.57377		ZMAT4	chr8	40530589	40897833	139339	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-53704	chr15	27656254	27656255	27411108	27411109	7943	hg38	N/A	enh31207	N/A	Enhatls57862	enhancer	E2531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02172	0.57377		GABRG3	chr15	26971180	27541984	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	406
enhrx-100000	chr2	220941740	220941741	220077019	220077020	7944	hg38	N/A	enh34283	N/A	Enhatls106992	enhancer	E2532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00030447	0.57418		SLC4A3	chr2	219627393	219641980	432805	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11926
enhrx-139006	chr6	14758948	14758949	14758717	14758718	7945	hg38	N/A	enh23058	N/A	Enhatls148610	enhancer	E2533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022499	0.57418		JARID2	chr6	15246068	15522042	483618	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-120518	chr3	161539200	161539201	161821412	161821413	7946	hg38	N/A	N/A	N/A	Enhatls128952	enhancer	E2534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036783	0.57418		OTOL1	chr3	161496807	161503942	299932	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8647
enhrx-78817	chr18	71984183	71984184	74316948	74316949	7947	hg38	N/A	N/A	N/A	Enhatls84558	enhancer	E2535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02944	0.57436		C18orf63	chr18	74315838	74359189	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2835
enhrx-90593	chr2	46534479	46534480	46307340	46307341	7948	hg38	N/A	enh18523	N/A	Enhatls97053	enhancer	E2536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038449	0.57436		EPAS1	chr2	46296607	46386697	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2519
enhrx-21516	chr10	81011461	81011462	79251704	79251705	7949	hg38	N/A	enh1382	N/A	Enhatls23682	enhancer	E2537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0014308	0.57436		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3951
enhrx-31038	chr11	72142267	72142268	72431223	72431224	7950	hg38	N/A	enh1864	N/A	Enhatls33748	enhancer	E2538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30905	0.575		CLPB	chr11	72285494	72434629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5707
enhrx-166228	chr9	97393352	97393353	94631070	94631071	7951	hg38	N/A	enh57054	fant32864	Enhatls177909	enhancer	E2539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0067455	0.57563		FBP1	chr9	94603132	94640249	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3495
enhrx-153958	chr7	127624042	127624043	127983989	127983990	7952	hg38	N/A	enh24488	N/A	Enhatls164526	enhancer	E2540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0022612	0.57563		SND1	chr7	127652193	128092593	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6770
enhrx-113336	chr3	32836322	32836323	32794830	32794831	7953	hg38	N/A	enh20483	N/A	Enhatls121270	enhancer	E2541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012726	0.57611		TRIM71	chr3	32817996	32897824	15585	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1465
enhrx-37140	chr12	31973974	31973975	31821040	31821041	7954	hg38	N/A	enh108526	N/A	Enhatls40248	enhancer	E2542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071012	0.57744		H3-5	chr12	31791184	31792298	27401	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2450
enhrx-131821	chr5	42036667	42036668	42036565	42036566	7955	hg38	N/A	N/A	N/A	Enhatls140899	enhancer	E2543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065252	0.57744		FBXO4	chr5	41925253	41941743	76231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1612
enhrx-68769	chr17	16821941	16821942	16918627	16918628	7956	hg38	N/A	enh81188	N/A	Enhatls73792	enhancer	E2544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026547	0.57776		TNFRSF13B	chr17	16933064	16972118	12364	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2038
enhrx-114089	chr3	44118872	44118873	44077380	44077381	7957	hg38	N/A	enh70564	N/A	Enhatls122091	enhancer	E2545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18178	0.57776		TOPAZ1	chr3	44241885	44332098	162379	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2218
enhrx-50784	chr14	69044752	69044753	68578035	68578036	7958	hg38	N/A	enh15717	N/A	Enhatls54768	enhancer	E2546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24827	0.57776		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2741
enhrx-113184	chr3	27575629	27575630	27534138	27534139	7959	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	E2547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0029939	0.57776		SLC4A7	chr3	27372720	27484420	44915	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1313
enhrx-113284	chr3	31794400	31794401	31752908	31752909	7960	hg38	N/A	enh97249	N/A	Enhatls121213	enhancer	E2548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012609	0.57776		OSBPL10	chr3	31657911	31981300	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1413
enhrx-141073	chr6	39155839	39155840	39188063	39188064	7961	hg38	N/A	enh23214	N/A	Enhatls150813	enhancer	E2549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07533	0.57776		KCNK5	chr6	39188970	39229475	482	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2661
enhrx-50782	chr14	68662051	68662052	68195334	68195335	7962	hg38	N/A	enh30989	N/A	Enhatls54763	enhancer	E2550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01276	0.57776		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-13065	chr1	179700939	179700940	179731804	179731805	7963	hg38	N/A	enh79272	N/A	Enhatls14431	enhancer	E2551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17268	0.57776		FAM163A	chr1	179743290	179816198	8231	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13064
enhrx-137529	chr5	170180772	170180773	170753768	170753769	7964	hg38	N/A	enh63489	N/A	Enhatls146978	enhancer	E2552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16685	0.57776		GABRP	chr5	170763349	170814047	5059	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7320
enhrx-97830	chr2	189228923	189228924	188364196	188364197	7965	hg38	N/A	enh70088	N/A	Enhatls104682	enhancer	E2553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010977	0.57776		GULP1	chr2	188291668	188595931	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9756
enhrx-78198	chr18	52755615	52755616	55088384	55088385	7966	hg38	N/A	enh96805	N/A	Enhatls83888	enhancer	E2554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15622	0.57776		CCDC68	chr18	54901508	54959461	126694	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2216
enhrx-51744	chr14	86840423	86840424	86374079	86374080	7967	hg38	N/A	enh15820	N/A	Enhatls55803	enhancer	E2555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061588	0.57776		FLRT2	chr14	85530143	85654428	717534	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3701
enhrx-5923	chr1	54380925	54380926	53915252	53915253	7968	hg38	N/A	enh367	N/A	Enhatls6459	enhancer	E2556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0098343	0.57776		DIO1	chr1	53892166	53911086	627	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5922
enhrx-120532	chr3	164352814	164352815	164635026	164635027	7969	hg38	N/A	enh97395	N/A	Enhatls128969	enhancer	E2557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087277	0.57776		SI	chr3	164978897	165078496	341071	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8661
enhrx-100067	chr2	223891246	223891247	223026528	223026529	7970	hg38	N/A	enh76576	N/A	Enhatls107060	enhancer	E2558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0074112	0.57776		KCNE4	chr2	223052189	223055637	22402	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11993
enhrx-55600	chr15	46147605	46147606	45855407	45855408	7971	hg38	N/A	enh58641	N/A	Enhatls59819	enhancer	E2559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044855	0.57776		SQOR	chr15	45631147	45691281	161247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2302
enhrx-146411	chr6	157519684	157519685	157198550	157198551	7972	hg38	N/A	N/A	N/A	Enhatls156496	enhancer	E2560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010819	0.57809		ARID1B	chr6	156776019	157210779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7999
enhrx-49108	chr14	35801453	35801454	35332247	35332248	7973	hg38	N/A	enh15582	N/A	Enhatls53011	enhancer	E2561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066048	0.57839		PSMA6	chr14	35278632	35317493	14426	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1065
enhrx-88795	chr2	19271680	19271681	19071919	19071920	7974	hg38	N/A	enh18311	N/A	Enhatls95132	enhancer	E2562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039084	0.57958		OSR1	chr2	19351484	19358623	277783	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	721
enhrx-66211	chr16	85679030	85679031	85645424	85645425	7975	hg38	N/A	enh16875	fant51292	Enhatls71079	enhancer	E2563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052916	0.57958		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6506
enhrx-67318	chr17	4417706	4417707	4514411	4514412	7976	hg38	N/A	enh16940	N/A	Enhatls72298	enhancer	E2564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073122	0.57958		SPNS2	chr17	4498880	4539035	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	587
enhrx-149362	chr7	41017327	41017328	40977729	40977730	7977	hg38	N/A	enh84612	N/A	Enhatls159636	enhancer	E2565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088454	0.57958		SUGCT	chr7	40135004	40860763	114925	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2174
enhrx-134395	chr5	107313399	107313400	107977698	107977699	7978	hg38	N/A	N/A	N/A	Enhatls143564	enhancer	E2566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15816	0.57958		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4186
enhrx-21654	chr10	84698280	84698281	82938524	82938525	7979	hg38	N/A	N/A	N/A	Enhatls23836	enhancer	E2567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087596	0.57986		NRG3	chr10	81875193	82987179	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4089
enhrx-19337	chr10	35224979	35224980	34936051	34936052	7980	hg38	N/A	enh13157	N/A	Enhatls21133	enhancer	E2568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023744	0.57994		CUL2	chr10	35008503	35127006	64473	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1772
enhrx-126637	chr4	89138499	89138500	88217347	88217348	7981	hg38	N/A	N/A	N/A	Enhatls135462	enhancer	E2569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095208	0.57995		ABCG2	chr4	88090149	88231628	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4181
enhrx-50989	chr14	72900629	72900630	72433921	72433922	7982	hg38	N/A	enh44027	N/A	Enhatls54990	enhancer	E2570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076123	0.5802		RGS6	chr14	71932428	72566530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2946
enhrx-34563	chr11	130914893	130914894	131044998	131044999	7983	hg38	N/A	N/A	N/A	Enhatls37503	enhancer	E2572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04654	0.58021		SNX19	chr11	130866249	130916479	128502	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9232
enhrx-52683	chr14	101947533	101947534	101481196	101481197	7984	hg38	N/A	enh51938	N/A	Enhatls56824	enhancer	E2573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047099	0.58028		DIO3	chr14	101560138	101563452	76601	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4640
enhrx-52616	chr14	100504626	100504627	100038289	100038290	7985	hg38	N/A	enh15935	fant47265	Enhatls56746	enhancer	E2574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094208	0.58166		EVL	chr14	99971448	100144236	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4573
enhrx-167042	chr9	112063529	112063530	109301249	109301250	7986	hg38	N/A	N/A	N/A	Enhatls178792	enhancer	E2575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014668	0.58166		EPB41L4B	chr9	109171973	109321059	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4309
enhrx-145372	chr6	135572783	135572784	135251645	135251646	7987	hg38	N/A	enh39536	N/A	Enhatls155369	enhancer	E2576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032355	0.58178		MYB	chr6	135181307	135219173	29115	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6960
enhrx-158051	chr8	37041821	37041822	37184303	37184304	7988	hg38	N/A	enh10235	N/A	Enhatls168859	enhancer	E2577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038155	0.58179		KCNU1	chr8	36784323	36936125	241783	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-40832	chr12	89586387	89586388	89192610	89192611	7989	hg38	N/A	enh14862	fant42513	Enhatls44126	enhancer	E2578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018054	0.58189		DUSP6	chr12	89347234	89352501	154395	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6142
enhrx-163296	chr9	14326477	14326478	14326478	14326479	7990	hg38	N/A	enh10676	N/A	Enhatls174375	enhancer	E2579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0074496	0.58189		NFIB	chr9	14081842	14398983	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	563
enhrx-88308	chr2	8808906	8808907	8668776	8668777	7991	hg38	N/A	enh102623	N/A	Enhatls94588	enhancer	E2580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07131	0.5824		ID2	chr2	8678844	8684461	7865	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	234
enhrx-16348	chr1	229548061	229548062	229412314	229412315	7992	hg38	N/A	enh12766	fant5164	Enhatls17940	enhancer	E2581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061532	0.5824		ACTA1	chr1	229430364	229434104	18027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16347
enhrx-123412	chr4	10008030	10008031	10006406	10006407	7993	hg38	N/A	enh21367	N/A	Enhatls132074	enhancer	E2582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11796	0.5824		SLC2A9	chr4	9826223	10054936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	956
enhrx-41179	chr12	98752329	98752330	98358551	98358552	7994	hg38	N/A	N/A	N/A	Enhatls44510	enhancer	E2583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038537	0.5824		TMPO	chr12	98515589	98550351	144532	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6489
enhrx-6301	chr1	61709898	61709899	61244226	61244227	7995	hg38	N/A	enh58096	N/A	Enhatls6871	enhancer	E2584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055907	0.58241		NFIA	chr1	60865258	61462788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6300
enhrx-158051	chr8	37002445	37002446	37144927	37144928	7996	hg38	N/A	enh24919	fant29265	Enhatls168859	enhancer	E2585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10432	0.58241		KCNU1	chr8	36784323	36936125	208684	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-102853	chr20	21642523	21642524	21661885	21661886	7997	hg38	N/A	enh97115	N/A	Enhatls109976	enhancer	E2586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000311	0.58241		PAX1	chr20	21705658	21718481	41782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1281
enhrx-149364	chr7	41547473	41547474	41507875	41507876	7998	hg38	N/A	enh93601	N/A	Enhatls159643	enhancer	E2587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024446	0.58275		INHBA	chr7	41685113	41705834	173977	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2176
enhrx-167268	chr9	114671828	114671829	111909548	111909549	7999	hg38	N/A	enh109219	N/A	Enhatls179015	enhancer	E2588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010394	0.58277		UGCG	chr9	111896813	111935369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4535
enhrx-14596	chr1	204417791	204417792	204448663	204448664	8000	hg38	N/A	enh12583	N/A	Enhatls16081	enhancer	E2589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13214	0.58277		PIK3C2B	chr1	204422627	204494805	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14595
enhrx-33529	chr11	118112431	118112432	118241716	118241717	8001	hg38	N/A	N/A	fant40058	Enhatls36385	enhancer	E2590	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040989	0.58277		MPZL3	chr11	118226689	118252365	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8198
enhrx-42830	chr12	116466537	116466538	116028732	116028733	8002	hg38	N/A	enh75180	N/A	Enhatls46250	enhancer	E2591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014942	0.58329		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8140
enhrx-120700	chr3	169341912	169341913	169624124	169624125	8003	hg38	N/A	enh95643	N/A	Enhatls129146	enhancer	E2592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04583	0.58329		MECOM	chr3	169083498	169663775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8829
enhrx-100102	chr2	225196548	225196549	224331831	224331832	8004	hg38	N/A	enh19272	N/A	Enhatls107097	enhancer	E2593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085128	0.58373		FAM124B	chr2	224378697	224402107	42800	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12028
enhrx-43328	chr12	122186937	122186938	121749031	121749032	8005	hg38	N/A	N/A	fant43417	Enhatls46772	enhancer	E2594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023096	0.58373		TMEM120B	chr12	121712751	121782068	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8638
enhrx-63911	chr16	54974762	54974763	54940850	54940851	8006	hg38	N/A	enh102292	N/A	Enhatls68596	enhancer	E2595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11398	0.58389		IRX5	chr16	54930864	54934485	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4206
enhrx-73791	chr17	63190964	63190965	65194846	65194847	8007	hg38	N/A	N/A	N/A	Enhatls79217	enhancer	E2596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082602	0.58503		RGS9	chr17	65100985	65227703	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7060
enhrx-53053	chr14	104811372	104811373	104345035	104345036	8008	hg38	N/A	enh96565	N/A	Enhatls57208	enhancer	E2597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065654	0.58503		TMEM179	chr14	104474677	104605647	126220	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5010
enhrx-157876	chr8	30182308	30182309	30324792	30324793	8009	hg38	N/A	enh24909	N/A	Enhatls168667	enhancer	E2598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056366	0.58503		RBPMS	chr8	30384510	30572256	51252	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1667
enhrx-123606	chr4	16053644	16053645	16052021	16052022	8010	hg38	N/A	N/A	N/A	Enhatls132285	enhancer	E2599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0095686	0.5852		PROM1	chr4	15968227	16084378	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1150
enhrx-90150	chr2	38014159	38014160	37787016	37787017	8011	hg38	N/A	enh18450	N/A	Enhatls96565	enhancer	E2600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091926	0.5852		CDC42EP3	chr2	37641881	37738468	46574	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2076
enhrx-111313	chr22	45486466	45486467	45090585	45090586	8012	hg38	N/A	enh97226	N/A	Enhatls119112	enhancer	E2601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22327	0.5852		NUP50	chr22	45163924	45188017	71103	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3144
enhrx-32416	chr11	100503825	100503826	100633094	100633095	8013	hg38	N/A	enh14219	N/A	Enhatls35199	enhancer	E2602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060758	0.5852		ARHGAP42	chr11	100687287	100993941	44404	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7085
enhrx-137619	chr5	171810519	171810520	172383515	172383516	8014	hg38	N/A	N/A	N/A	Enhatls147080	enhancer	E2603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053024	0.5852		SH3PXD2B	chr5	172324999	172454525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7410
enhrx-49454	chr14	50016359	50016360	49549641	49549642	8015	hg38	N/A	enh51811	N/A	Enhatls53355	enhancer	E2604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062118	0.58557		RPS29	chr14	49570983	49598690	20867	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1411
enhrx-46810	chr13	78011608	78011609	77437473	77437474	8016	hg38	N/A	N/A	N/A	Enhatls50533	enhancer	E2605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039906	0.58557		SCEL	chr13	77535673	77645263	90164	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2432
enhrx-105093	chr20	48758932	48758933	50142395	50142396	8017	hg38	N/A	enh6528	N/A	Enhatls112379	enhancer	E2606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11548	0.58557		PEDS1-UBE2V1	chr20	50081123	50153637	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3521
enhrx-105093	chr20	48758932	48758933	50142395	50142396	8018	hg38	N/A	enh6528	N/A	Enhatls112379	enhancer	E2606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11548	0.58557		PEDS1	chr20	50118253	50153734	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3521
enhrx-27984	chr11	37126103	37126104	37104553	37104554	8019	hg38	N/A	enh13905	N/A	Enhatls30454	enhancer	E2607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13514	0.58557		IFTAP	chr11	36594368	36659291	436165	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2653
enhrx-29456	chr11	62194476	62194477	62427004	62427005	8020	hg38	N/A	enh13972	N/A	Enhatls32007	enhancer	E2608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056084	0.58557		AHNAK	chr11	62433541	62556235	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4125
enhrx-124121	chr4	38874500	38874501	38872879	38872880	8021	hg38	N/A	enh21454	N/A	Enhatls132828	enhancer	E2609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030892	0.58557		FAM114A1	chr4	38867676	38945739	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1665
enhrx-28276	chr11	46541051	46541052	46519501	46519502	8022	hg38	N/A	enh1753	N/A	Enhatls30772	enhancer	E2610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14999	0.58557		AMBRA1	chr11	46396413	46594125	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2945
enhrx-120407	chr3	159532275	159532276	159814486	159814487	8023	hg38	N/A	enh21068	N/A	Enhatls128834	enhancer	E2611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017775	0.58557		IQCJ-SCHIP1	chr3	159069251	159897629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8536
enhrx-65763	chr16	75788272	75788273	75754374	75754375	8024	hg38	N/A	enh52323	N/A	Enhatls70571	enhancer	E2612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15699	0.58557		TERF2IP	chr16	75647772	75761872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6058
enhrx-88852	chr2	20384100	20384101	20184339	20184340	8025	hg38	N/A	enh18325	N/A	Enhatls95187	enhancer	E2613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16542	0.58579		SDC1	chr2	20200796	20225433	15285	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	778
enhrx-113941	chr3	41849886	41849887	41808394	41808395	8026	hg38	N/A	enh45389	N/A	Enhatls121930	enhancer	E2614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1204	0.58579		ULK4	chr3	41246598	41962130	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2070
enhrx-167692	chr9	122031750	122031751	119269472	119269473	8027	hg38	N/A	N/A	N/A	Enhatls179478	enhancer	E2615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059165	0.58579		BRINP1	chr9	119166628	119369435	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4959
enhrx-161197	chr8	119012822	119012823	118000583	118000584	8028	hg38	N/A	enh25238	N/A	Enhatls172165	enhancer	E2616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032652	0.58698		EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4988
enhrx-70133	chr17	32761235	32761236	34434216	34434217	8029	hg38	N/A	enh94306	N/A	Enhatls75266	enhancer	E2617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11318	0.58708		CCL1	chr17	34360327	34363233	67894	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3402
enhrx-82379	chr19	16574948	16574949	16464137	16464138	8030	hg38	N/A	enh5033	fant56468	Enhatls88338	enhancer	E2618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0037934	0.58761		EPS15L1	chr19	16355238	16472085	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3349
enhrx-102953	chr20	24963976	24963977	24983340	24983341	8031	hg38	N/A	enh107865	N/A	Enhatls110078	enhancer	E2619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20862	0.58761		APMAP	chr20	24962924	24992751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1381
enhrx-112661	chr3	14464891	14464892	14423383	14423384	8032	hg38	N/A	enh7018	N/A	Enhatls120557	enhancer	E2620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05482	0.58761		SLC6A6	chr3	14402575	14489349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	790
enhrx-34404	chr11	128477976	128477977	128608081	128608082	8033	hg38	N/A	enh2107	N/A	Enhatls37328	enhancer	E2621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031058	0.58921		ETS1	chr11	128458760	128587558	7869	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9073
enhrx-57459	chr15	71678072	71678073	71385733	71385734	8034	hg38	N/A	enh57671	N/A	Enhatls61823	enhancer	E2622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14537	0.58921		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4161
enhrx-14295	chr1	202056231	202056232	202087103	202087104	8035	hg38	N/A	enh12534	fant4334	Enhatls15738	enhancer	E2623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1282	0.5901		GPR37L1	chr1	202122885	202133592	35395	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14294
enhrx-33131	chr11	112163943	112163944	112293220	112293221	8036	hg38	N/A	enh29147	N/A	Enhatls35955	enhancer	E2624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050028	0.5901		PLET1	chr11	112248152	112260860	23263	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7800
enhrx-99583	chr2	218112363	218112364	217247640	217247641	8037	hg38	N/A	enh48414	N/A	Enhatls106542	enhancer	E2625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081125	0.59211		TNP1	chr2	216859457	216860064	385399	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11509
enhrx-88518	chr2	11076556	11076557	10936430	10936431	8038	hg38	N/A	enh33055	fant5954	Enhatls94827	enhancer	E2626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099583	0.59294		KCNF1	chr2	10911933	10914225	21918	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	444
enhrx-121826	chr3	188000922	188000923	188283134	188283135	8039	hg38	N/A	enh48785	N/A	Enhatls130375	enhancer	E2627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11601	0.59339		LPP	chr3	188153283	188890671	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9955
enhrx-36082	chr12	12736069	12736070	12583135	12583136	8040	hg38	N/A	enh14536	fant41016	Enhatls39133	enhancer	E2628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16366	0.59339		DUSP16	chr12	12473281	12562863	20026	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1392
enhrx-114558	chr3	47590810	47590811	47549320	47549321	8041	hg38	N/A	N/A	N/A	Enhatls122591	enhancer	E2629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084155	0.59339		CSPG5	chr3	47562237	47580792	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2687
enhrx-9422	chr1	116996354	116996355	116453732	116453733	8042	hg38	N/A	enh584	N/A	Enhatls10173	enhancer	E2630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049183	0.59342		ATP1A1	chr1	116372667	116410261	42908	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9421
enhrx-92667	chr2	88781706	88781707	88482188	88482189	8043	hg38	N/A	enh96918	N/A	Enhatls99275	enhancer	E2631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059439	0.59342		FOXI3	chr2	88446786	88452693	27415	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4593
enhrx-50782	chr14	68864647	68864648	68397930	68397931	8044	hg38	N/A	enh15712	fant46438	Enhatls54764	enhancer	E2632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033848	0.59342		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-169707	chr9	138944082	138944083	136052236	136052237	8045	hg38	N/A	enh78801	N/A	Enhatls181633	enhancer	E2633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026102	0.59342		NACC2	chr9	136006536	136095289	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6974
enhrx-34851	chr12	1628569	1628570	1519403	1519404	8046	hg38	N/A	enh29322	N/A	Enhatls37816	enhancer	E2634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02207	0.59369		WNT5B	chr12	1529890	1647212	8199	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	161
enhrx-26921	chr11	17008936	17008937	16987389	16987390	8047	hg38	N/A	enh13816	fant38075	Enhatls29351	enhancer	E2635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04615	0.59369		PLEKHA7	chr11	16777296	17014415	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-34452	chr11	129327410	129327411	129457515	129457516	8048	hg38	N/A	enh14390	fant40455	Enhatls37379	enhancer	E2636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070976	0.59578		BARX2	chr11	129375847	129452279	5052	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9121
enhrx-43551	chr12	123320856	123320857	122836309	122836310	8049	hg38	N/A	enh15072	fant43453	Enhatls47007	enhancer	E2637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013894	0.59578		HIP1R	chr12	122835456	122862961	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8861
enhrx-150353	chr7	68278987	68278988	68814000	68814001	8050	hg38	N/A	enh89123	N/A	Enhatls160729	enhancer	E2638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044907	0.59578		AUTS2	chr7	69598295	70793506	782248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3165
enhrx-94913	chr2	129064080	129064081	128306506	128306507	8051	hg38	N/A	enh18864	N/A	Enhatls101625	enhancer	E2639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020982	0.59578		HS6ST1	chr2	128265479	128318868	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6839
enhrx-132419	chr5	61629396	61629397	62333569	62333570	8052	hg38	N/A	N/A	N/A	Enhatls141520	enhancer	E2640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011768	0.59578		KIF2A	chr5	62306161	62391025	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2210
enhrx-18137	chr10	12307861	12307862	12265862	12265863	8053	hg38	N/A	enh27799	fant34779	Enhatls19825	enhancer	E2641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023355	0.59578		CDC123	chr10	12195964	12250589	15106	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	572
enhrx-160634	chr8	101429671	101429672	100417443	100417444	8054	hg38	N/A	enh10450	N/A	Enhatls171576	enhancer	E2642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18324	0.59578		ANKRD46	chr8	100509751	100559784	77072	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4425
enhrx-142391	chr6	57063848	57063849	57199050	57199051	8055	hg38	N/A	enh72273	N/A	Enhatls152222	enhancer	E2643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0027003	0.59578		RAB23	chr6	57186991	57222307	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3979
enhrx-152347	chr7	99735619	99735620	100137996	100137997	8056	hg38	N/A	enh24364	N/A	Enhatls162816	enhancer	E2644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18136	0.59579		LAMTOR4	chr7	100148911	100155944	5040	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5159
enhrx-49673	chr14	51674553	51674554	51207835	51207836	8057	hg38	N/A	enh43992	N/A	Enhatls53593	enhancer	E2645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12475	0.59579		TMX1	chr14	51240246	51257655	28973	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1630
enhrx-30835	chr11	70029742	70029743	70183636	70183637	8058	hg38	N/A	N/A	N/A	Enhatls33528	enhancer	E2646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0079757	0.59579		ANO1	chr11	69985906	70189530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5504
enhrx-41867	chr12	107038902	107038903	106645124	106645125	8059	hg38	N/A	N/A	N/A	Enhatls45237	enhancer	E2647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086494	0.59579		RFX4	chr12	106583003	106762803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7177
enhrx-148828	chr7	30656103	30656104	30616487	30616488	8060	hg38	N/A	N/A	N/A	Enhatls159061	enhancer	E2648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056729	0.59579		GARS1	chr7	30580532	30634033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-111571	chr22	50249544	50249545	49855896	49855897	8061	hg38	N/A	N/A	N/A	Enhatls119402	enhancer	E2649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038899	0.59579		ZBED4	chr22	49853843	49890080	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3402
enhrx-153113	chr7	105820426	105820427	106179980	106179981	8062	hg38	N/A	enh24400	N/A	Enhatls163630	enhancer	E2650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091232	0.59579		SYPL1	chr7	106090504	106112589	62050	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5925
enhrx-172216	chrX	45481016	45481017	45621771	45621772	8063	hg38	N/A	enh42598	fant62386	Enhatls184260	enhancer	E2651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11982	0.59579		DIPK2B	chrX	45148372	45200901	420755	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1933
enhrx-146132	chr6	151990144	151990145	151669009	151669010	8064	hg38	N/A	enh84451	fant24693	Enhatls156204	enhancer	E2652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041119	0.59579		ESR1	chr6	151690495	152129619	21194	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-38648	chr12	53221148	53221149	52827364	52827365	8065	hg38	N/A	enh14732	N/A	Enhatls41816	enhancer	E2653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064229	0.59579		KRT79	chr12	52821407	52834311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3958
enhrx-19574	chr10	43836115	43836116	43340667	43340668	8066	hg38	N/A	enh50392	N/A	Enhatls21364	enhancer	E2654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072232	0.59579		FXYD4	chr10	43371635	43376335	28725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2009
enhrx-170700	chrX	8694245	8694246	8726204	8726205	8067	hg38	N/A	N/A	N/A	Enhatls182665	enhancer	E2655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041637	0.59579		ANOS1	chrX	8528873	8732137	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	417
enhrx-88296	chr2	7885703	7885704	7745572	7745573	8068	hg38	N/A	enh58864	N/A	Enhatls94564	enhancer	E2656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086433	0.59579		RNF144A	chr2	6917411	7068286	676368	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	222
enhrx-167584	chr9	117566967	117566968	114804687	114804688	8069	hg38	N/A	N/A	N/A	Enhatls179353	enhancer	E2657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050793	0.59625		TNFSF15	chr9	114784651	114806039	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4851
enhrx-105292	chr20	55167653	55167654	56592597	56592598	8070	hg38	N/A	enh19777	N/A	Enhatls112607	enhancer	E2658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063909	0.59625		TFAP2C	chr20	56629305	56639283	31028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3720
enhrx-20319	chr10	60616492	60616493	58856732	58856733	8071	hg38	N/A	enh13225	N/A	Enhatls22381	enhancer	E2659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00445	0.59625		BICC1	chr10	58512871	58831435	22411	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2754
enhrx-3199	chr1	27470211	27470212	27143720	27143721	8072	hg38	N/A	enh171	N/A	Enhatls3556	enhancer	E2660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041677	0.59625		SLC9A1	chr1	27098808	27166981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3198
enhrx-160675	chr8	102422287	102422288	101410059	101410060	8073	hg38	N/A	enh98174	N/A	Enhatls171623	enhancer	E2661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065252	0.59625		GRHL2	chr8	101492438	101669726	80192	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-134525	chr5	111349568	111349569	112013871	112013872	8074	hg38	N/A	enh83935	N/A	Enhatls143695	enhancer	E2662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044354	0.59702		NREP	chr5	111669190	111997464	12885	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4316
enhrx-104046	chr20	36474848	36474849	37846446	37846447	8075	hg38	N/A	enh97122	N/A	Enhatls111278	enhancer	E2663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030574	0.59757		CTNNBL1	chr20	37693954	37872129	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2474
enhrx-109570	chr22	30608665	30608666	30212676	30212677	8076	hg38	N/A	enh20126	fant61006	Enhatls117249	enhancer	E2664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011664	0.59757		LIF	chr22	30240452	30246759	27336	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1401
enhrx-17893	chr10	6297562	6297563	6255599	6255600	8077	hg38	N/A	N/A	N/A	Enhatls19554	enhancer	E2665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083557	0.59757		PFKFB3	chr10	6144933	6254644	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	328
enhrx-61059	chr16	9097435	9097436	9003578	9003579	8078	hg38	N/A	enh31686	N/A	Enhatls65636	enhancer	E2666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017911	0.59757		USP7	chr16	8892096	8975328	26145	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1354
enhrx-93736	chr2	107177353	107177354	106560897	106560898	8079	hg38	N/A	enh65312	N/A	Enhatls100393	enhancer	E2667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14966	0.59757		CD8B2	chr2	106487363	106544297	14573	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5662
enhrx-15826	chr1	223593197	223593198	223419855	223419856	8080	hg38	N/A	enh87692	N/A	Enhatls17372	enhancer	E2668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056408	0.59757		CCDC185	chr1	223393414	223395465	23639	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15825
enhrx-165469	chr9	80782471	80782472	78167555	78167556	8081	hg38	N/A	enh98249	N/A	Enhatls177078	enhancer	E2669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016335	0.59757		CEP78	chr9	78236061	78279690	66463	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2736
enhrx-44687	chr13	24795427	24795428	24221289	24221290	8082	hg38	N/A	enh2724	N/A	Enhatls48219	enhancer	E2670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.004234	0.59757		SPATA13	chr13	23979804	24307074	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	309
enhrx-130152	chr4	187575362	187575363	186654208	186654209	8083	hg38	N/A	N/A	N/A	Enhatls139139	enhancer	E2671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028039	0.59757		FAT1	chr4	186587793	186726722	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7696
enhrx-85564	chr19	45300070	45300071	44796813	44796814	8084	hg38	N/A	enh65192	N/A	Enhatls91703	enhancer	E2672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052756	0.59766		CBLC	chr19	44777868	44800652	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6534
enhrx-17148	chr1	241870548	241870549	241707246	241707247	8085	hg38	N/A	enh61991	N/A	Enhatls18765	enhancer	E2673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048976	0.59766		WDR64	chr1	241652277	241802777	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17147
enhrx-142505	chr6	68389556	68389557	67679663	67679664	8086	hg38	N/A	enh39111	N/A	Enhatls152349	enhancer	E2674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13872	0.59804		ADGRB3	chr6	68635281	69389506	949080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4093
enhrx-49223	chr14	38095607	38095608	37626402	37626403	8087	hg38	N/A	enh80777	N/A	Enhatls53123	enhancer	E2675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12143	0.59841		TTC6	chr14	37595628	37842717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-111997	chr3	4260771	4260772	4219087	4219088	8088	hg38	N/A	enh91415	N/A	Enhatls119838	enhancer	E2676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074977	0.59841		SETMAR	chr3	4303360	4317265	76010	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	126
enhrx-99583	chr2	218058387	218058388	217193664	217193665	8089	hg38	N/A	enh89426	N/A	Enhatls106542	enhancer	E2677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056131	0.59864		TNP1	chr2	216859457	216860064	331459	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11509
enhrx-128107	chr4	123867334	123867335	122946179	122946180	8090	hg38	N/A	N/A	N/A	Enhatls136981	enhancer	E2678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16123	0.59864		AFG2A	chr4	122923069	123319433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5651
enhrx-130900	chr5	14864647	14864648	14864538	14864539	8091	hg38	N/A	enh55170	N/A	Enhatls139919	enhancer	E2679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038073	0.59864		ANKH	chr5	14704799	14871778	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	691
enhrx-140521	chr6	34384109	34384110	34416332	34416333	8092	hg38	N/A	enh63527	N/A	Enhatls150225	enhancer	E2680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033897	0.59865		RPS10-NUDT3	chr6	34284886	34426071	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2109
enhrx-88296	chr2	7932475	7932476	7792344	7792345	8093	hg38	N/A	enh5270	N/A	Enhatls94564	enhancer	E2681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039837	0.59865		RNF144A	chr2	6917411	7068286	721909	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	222
enhrx-431	chr1	1933488	1933489	2002049	2002050	8094	hg38	N/A	enh11416	N/A	Enhatls442	enhancer	E2682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062143	0.59958		CFAP74	chr1	1921950	2003837	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	430
enhrx-130226	chr5	160450	160451	160335	160336	8095	hg38	N/A	enh37522	N/A	Enhatls139204	enhancer	E2683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071826	0.59958		PLEKHG4B	chr5	92167	189972	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17
enhrx-103162	chr20	30266597	30266598	31678794	31678795	8096	hg38	N/A	enh6337	fant58363	Enhatls110296	enhancer	E2684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0022192	0.59958		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-26242	chr11	6659327	6659328	6638096	6638097	8097	hg38	N/A	N/A	N/A	Enhatls28604	enhancer	E2685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078181	0.59958		DCHS1	chr11	6621329	6655809	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	911
enhrx-59974	chr16	1205118	1205119	1155118	1155119	8098	hg38	N/A	enh31663	N/A	Enhatls64523	enhancer	E2686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01485	0.59958		CACNA1H	chr16	1153105	1221771	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	269
enhrx-45079	chr13	30646836	30646837	30072699	30072700	8099	hg38	N/A	enh15196	N/A	Enhatls48633	enhancer	E2687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011537	0.59958		KATNAL1	chr13	30202629	30307551	127812	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	701
enhrx-110725	chr22	40793137	40793138	40397133	40397134	8100	hg38	N/A	enh6871	N/A	Enhatls118493	enhancer	E2688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12974	0.59958		SGSM3	chr22	40370590	40410289	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2556
enhrx-71601	chr17	41438578	41438579	43361210	43361211	8101	hg38	N/A	enh4419	N/A	Enhatls76840	enhancer	E2689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068211	0.59958		ARL4D	chr17	43398992	43401137	34711	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4870
enhrx-64069	chr16	56822536	56822537	56788624	56788625	8102	hg38	N/A	enh4043	N/A	Enhatls68768	enhancer	E2690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1064	0.59958		NUP93	chr16	56730117	56850286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4364
enhrx-155810	chr7	151615178	151615179	151918093	151918094	8103	hg38	N/A	enh56533	N/A	Enhatls166474	enhancer	E2691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070447	0.59958		GALNTL5	chr7	151956378	152019929	35825	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8622
enhrx-145237	chr6	132785909	132785910	132464770	132464771	8104	hg38	N/A	enh23608	N/A	Enhatls155199	enhancer	E2692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063035	0.59958		STX7	chr6	132445866	132513198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6825
enhrx-146132	chr6	151998659	151998660	151677524	151677525	8105	hg38	N/A	enh23791	fant24695	Enhatls156204	enhancer	E2693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12075	0.60127		ESR1	chr6	151690495	152129619	12845	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7720
enhrx-158373	chr8	40194532	40194533	40337013	40337014	8106	hg38	N/A	enh40928	N/A	Enhatls169206	enhancer	E2694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023157	0.60182		TCIM	chr8	40153481	40155310	176575	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-15343	chr1	212895000	212895001	212721658	212721659	8107	hg38	N/A	enh27472	N/A	Enhatls16869	enhancer	E2695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10656	0.60185		NSL1	chr1	212726152	212791782	3417	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15342
enhrx-59426	chr15	98956310	98956311	98413081	98413082	8108	hg38	N/A	N/A	N/A	Enhatls63992	enhancer	E2696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071909	0.60185		IGF1R	chr15	98648538	98964530	234545	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6128
enhrx-65849	chr16	78495706	78495707	78461809	78461810	8109	hg38	N/A	enh81151	N/A	Enhatls70660	enhancer	E2697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012882	0.60185		WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6144
enhrx-64199	chr16	57375752	57375753	57341840	57341841	8110	hg38	N/A	enh62556	N/A	Enhatls68913	enhancer	E2698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0011273	0.60186		CCL22	chr16	57358782	57366189	15482	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4494
enhrx-11225	chr1	156687474	156687475	156717682	156717683	8111	hg38	N/A	N/A	N/A	Enhatls12493	enhancer	E2699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068247	0.60224		ISG20L2	chr1	156721890	156728766	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11224
enhrx-128977	chr4	154406724	154406725	153485572	153485573	8112	hg38	N/A	enh21894	N/A	Enhatls137898	enhancer	E2700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19506	0.60271		TMEM131L	chr4	153466345	153636711	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6521
enhrx-165936	chr9	93686290	93686291	90924008	90924009	8113	hg38	N/A	enh25733	N/A	Enhatls177583	enhancer	E2701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018735	0.60271		SYK	chr9	90801786	90898549	22928	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3203
enhrx-33954	chr11	121197023	121197024	121326314	121326315	8114	hg38	N/A	enh2054	N/A	Enhatls36840	enhancer	E2702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080098	0.60271		SC5D	chr11	121292770	121313410	12065	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8623
enhrx-93873	chr2	109598967	109598968	108982511	108982512	8115	hg38	N/A	N/A	N/A	Enhatls100534	enhancer	E2703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099055	0.60271		EDAR	chr2	108894470	108989372	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5799
enhrx-133391	chr5	77927932	77927933	78632109	78632110	8116	hg38	N/A	N/A	N/A	Enhatls142514	enhancer	E2704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057071	0.60271		LHFPL2	chr5	78485214	78648772	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3182
enhrx-11885	chr1	161451989	161451990	161482199	161482200	8117	hg38	N/A	N/A	N/A	Enhatls13166	enhancer	E2705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14466	0.60271		FCGR2A	chr1	161505429	161519967	20362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11884
enhrx-96060	chr2	159580627	159580628	158724115	158724116	8118	hg38	N/A	enh62866	N/A	Enhatls102831	enhancer	E2706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093997	0.60319		PKP4	chr2	158456951	158682879	38155	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7986
enhrx-117420	chr3	111589155	111589156	111870308	111870309	8119	hg38	N/A	enh20809	N/A	Enhatls125665	enhancer	E2707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10913	0.60319		PHLDB2	chr3	111732496	111976517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-3562	chr1	31702017	31702018	31229170	31229171	8120	hg38	N/A	enh78995	N/A	Enhatls3942	enhancer	E2708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030789	0.60335		NKAIN1	chr1	31179744	31239887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3561
enhrx-19337	chr10	35255070	35255071	34966142	34966143	8121	hg38	N/A	enh13159	N/A	Enhatls21133	enhancer	E2709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20719	0.60335		CUL2	chr10	35008503	35127006	41340	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1772
enhrx-41815	chr12	106426023	106426024	106032245	106032246	8122	hg38	N/A	enh14958	N/A	Enhatls45183	enhancer	E2710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0023016	0.60348		NUAK1	chr12	106063344	106138954	28508	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7125
enhrx-24056	chr10	116662089	116662090	114902330	114902331	8123	hg38	N/A	N/A	N/A	Enhatls26410	enhancer	E2711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12547	0.60348		FHIP2A	chr10	114821743	114899832	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6491
enhrx-36596	chr12	22041542	22041543	21888608	21888609	8124	hg38	N/A	N/A	N/A	Enhatls39677	enhancer	E2712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083901	0.60348		ABCC9	chr12	21797388	21942529	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1906
enhrx-117140	chr3	105240876	105240877	105522032	105522033	8125	hg38	N/A	enh35710	N/A	Enhatls125357	enhancer	E2714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020853	0.60389		ALCAM	chr3	105366908	105576900	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5269
enhrx-18950	chr10	27277008	27277009	26988079	26988080	8126	hg38	N/A	N/A	N/A	Enhatls20713	enhancer	E2715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044554	0.60494		ANKRD26	chr10	26991913	27100494	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1385
enhrx-150887	chr7	75194708	75194709	75565404	75565405	8127	hg38	N/A	N/A	N/A	Enhatls161302	enhancer	E2716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07782	0.60521		HIP1	chr7	75533297	75738941	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3699
enhrx-20054	chr10	50627213	50627214	49419167	49419168	8128	hg38	N/A	enh13201	N/A	Enhatls22017	enhancer	E2717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055032	0.60544		DRGX	chr10	49364065	49396089	19031	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2489
enhrx-39920	chr12	66631763	66631764	66237983	66237984	8129	hg38	N/A	enh43760	N/A	Enhatls43160	enhancer	E2718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21724	0.60545		IRAK3	chr12	66189194	66254622	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5230
enhrx-158051	chr8	36901996	36901997	37044478	37044479	8130	hg38	N/A	enh56644	N/A	Enhatls168859	enhancer	E2719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03821	0.60675		KCNU1	chr8	36784323	36936125	104823	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-23641	chr10	107012823	107012824	105253065	105253066	8131	hg38	N/A	N/A	N/A	Enhatls25949	enhancer	E2720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012511	0.60675		SORCS3	chr10	104641289	105265242	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6076
enhrx-174084	chrX	77958559	77958560	78703062	78703063	8132	hg38	N/A	N/A	N/A	Enhatls186252	enhancer	E2721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019272	0.60675		LPAR4	chrX	78747719	78758714	24152	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3801
enhrx-168058	chr9	127153186	127153187	124390907	124390908	8133	hg38	N/A	enh10985	N/A	Enhatls179878	enhancer	E2722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023721	0.60761		PSMB7	chr9	124353464	124415444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5325
enhrx-66549	chr16	89412118	89412119	89345710	89345711	8134	hg38	N/A	enh16906	N/A	Enhatls71455	enhancer	E2723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041222	0.60836		ANKRD11	chr16	89267629	89490561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6844
enhrx-150355	chr7	69245544	69245545	69780558	69780559	8135	hg38	N/A	enh9846	N/A	Enhatls160731	enhancer	E2724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0036369	0.60987		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3167
enhrx-67712	chr17	7068149	7068150	7164830	7164831	8136	hg38	N/A	enh16958	N/A	Enhatls72689	enhancer	E2725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012567	0.60987		ASGR1	chr17	7173430	7179564	1955	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	981
enhrx-91037	chr2	56537349	56537350	56310214	56310215	8137	hg38	N/A	enh53086	N/A	Enhatls97546	enhancer	E2726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11567	0.61014		CCDC85A	chr2	56183989	56386172	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2963
enhrx-121844	chr3	189176435	189176436	189458646	189458647	8138	hg38	N/A	enh90218	N/A	Enhatls130397	enhancer	E2727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10327	0.61014		TPRG1	chr3	188947213	189325304	129842	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9973
enhrx-99586	chr2	218196534	218196535	217331811	217331812	8139	hg38	N/A	enh19226	N/A	Enhatls106547	enhancer	E2728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0065341	0.611		TNS1	chr2	217799587	218033982	457116	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11512
enhrx-14622	chr1	204732901	204732902	204763773	204763774	8140	hg38	N/A	enh43114	N/A	Enhatls16110	enhancer	E2729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23744	0.611		NFASC	chr1	204828651	205022822	62497	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14621
enhrx-109156	chr22	25572969	25572970	25177002	25177003	8141	hg38	N/A	N/A	N/A	Enhatls116811	enhancer	E2730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10143	0.61114		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	987
enhrx-116746	chr3	89553232	89553233	89504082	89504083	8142	hg38	N/A	enh97300	N/A	Enhatls124934	enhancer	E2731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049254	0.61114		EPHA3	chr3	89107620	89482134	19842	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4875
enhrx-20818	chr10	71491164	71491165	69731408	69731409	8143	hg38	N/A	enh13276	N/A	Enhatls22921	enhancer	E2732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039754	0.61114		COL13A1	chr10	69801879	69959148	64941	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3253
enhrx-4261	chr1	37230529	37230530	36764928	36764929	8144	hg38	N/A	N/A	N/A	Enhatls4695	enhancer	E2733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11185	0.61114		GRIK3	chr1	36795526	37034515	27356	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4260
enhrx-177018	chrX	149865115	149865116	150696642	150696643	8145	hg38	N/A	enh47113	N/A	Enhatls189268	enhancer	E2734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023498	0.61235		MTMR1	chrX	150692970	150765108	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6735
enhrx-148633	chr7	26444398	26444399	26404778	26404779	8146	hg38	N/A	N/A	N/A	Enhatls158849	enhancer	E2735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094301	0.61258		SNX10	chr7	26291861	26374383	29128	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1445
enhrx-18016	chr10	8449627	8449628	8407664	8407665	8147	hg38	N/A	enh12976	N/A	Enhatls19681	enhancer	E2736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076098	0.61258		GATA3	chr10	8045377	8075198	332408	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	451
enhrx-91438	chr2	67157328	67157329	66930196	66930197	8148	hg38	N/A	enh53127	N/A	Enhatls97982	enhancer	E2737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068809	0.61302		MEIS1	chr2	66435124	66573869	353820	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3364
enhrx-167065	chr9	112318479	112318480	109556199	109556200	8149	hg38	N/A	enh25891	N/A	Enhatls178815	enhancer	E2738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050132	0.61302		PALM2AKAP2	chr9	109498324	110172512	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4332
enhrx-84212	chr19	38432753	38432754	37942113	37942114	8150	hg38	N/A	enh5116	N/A	Enhatls90271	enhancer	E2739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092988	0.61302		SIPA1L3	chr19	37907207	38208369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5182
enhrx-40888	chr12	92437148	92437149	92043372	92043373	8151	hg38	N/A	enh47613	N/A	Enhatls44190	enhancer	E2740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020064	0.61302		BTG1	chr12	92140277	92145846	88702	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6198
enhrx-148383	chr7	21753040	21753041	21713422	21713423	8152	hg38	N/A	N/A	N/A	Enhatls158571	enhancer	E2741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01675	0.61302		DNAH11	chr7	21543038	21901839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1195
enhrx-169226	chr9	135628296	135628297	132752909	132752910	8153	hg38	N/A	enh102231	N/A	Enhatls181150	enhancer	E2742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056808	0.6152		AK8	chr9	132725577	132878284	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6493
enhrx-6321	chr1	62209617	62209618	61743945	61743946	8154	hg38	N/A	enh61860	N/A	Enhatls6893	enhancer	E2743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030421	0.61615		PATJ	chr1	61742476	62178675	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6320
enhrx-27944	chr11	35868903	35868904	35847353	35847354	8155	hg38	N/A	N/A	N/A	Enhatls30412	enhancer	E2744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10534	0.61615		TRIM44	chr11	35662774	35818007	11239	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2613
enhrx-130933	chr5	16492984	16492985	16492875	16492876	8156	hg38	N/A	enh22070	N/A	Enhatls139952	enhancer	E2745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052314	0.61615		RETREG1	chr5	16473052	16617101	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	724
enhrx-150346	chr7	67131595	67131596	67666608	67666609	8157	hg38	N/A	N/A	N/A	Enhatls160722	enhancer	E2746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030199	0.61615		SPDYE21	chr7	67276940	67289005	332051	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3158
enhrx-129816	chr4	178432955	178432956	177511801	177511802	8158	hg38	N/A	enh21966	N/A	Enhatls138766	enhancer	E2747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055212	0.61615		AGA	chr4	177430773	177442437	60715	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7360
enhrx-106723	chr21	33394277	33394278	32021964	32021965	8159	hg38	N/A	enh45201	N/A	Enhatls114109	enhancer	E2748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34789	0.61679		HUNK	chr21	31873019	32044633	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	606
enhrx-166961	chr9	110893422	110893423	108131142	108131143	8160	hg38	N/A	enh73777	N/A	Enhatls178703	enhancer	E2749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14529	0.61679		KLF4	chr9	107484851	107490482	638501	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-33452	chr11	117588712	117588713	117717997	117717998	8161	hg38	N/A	enh43628	N/A	Enhatls36306	enhancer	E2750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030448	0.61725		DSCAML1	chr11	117427771	117817525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8121
enhrx-113990	chr3	42597980	42597981	42556488	42556489	8162	hg38	N/A	N/A	N/A	Enhatls121985	enhancer	E2751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10989	0.61725		SEC22C	chr3	42547968	42601080	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2119
enhrx-79027	chr18	77934703	77934704	80176820	80176821	8163	hg38	N/A	enh32869	N/A	Enhatls84775	enhancer	E2752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18621	0.61803		PARD6G	chr18	80157231	80247514	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3045
enhrx-132237	chr5	55724971	55724972	56429144	56429145	8164	hg38	N/A	enh22246	fant18559	Enhatls141322	enhancer	E2753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1074	0.61803		ANKRD55	chr5	56099679	56233330	195784	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-15174	chr1	209989790	209989791	209816445	209816446	8165	hg38	"hs932,hs932,hs932,hs932,hs932"	enh12623	N/A	Enhatls16694	enhancer	E2754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00035826	0.61803		IRF6	chr1	209785616	209806175	10174	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15173
enhrx-896	chr1	7508008	7508009	7447948	7447949	8166	hg38	N/A	enh87563	N/A	Enhatls951	enhancer	E2755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0069616	0.61803		CAMTA1	chr1	6785453	7769706	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	895
enhrx-109154	chr22	25530216	25530217	25134249	25134250	8167	hg38	N/A	enh63061	N/A	Enhatls116809	enhancer	E2756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024891	0.61803		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	985
enhrx-158864	chr8	53738978	53738979	52826418	52826419	8168	hg38	N/A	enh41001	N/A	Enhatls169708	enhancer	E2757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050184	0.61803		RB1CC1	chr8	52622457	52745843	70969	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2655
enhrx-73995	chr17	66374939	66374940	68378798	68378799	8169	hg38	N/A	enh17332	fant53501	Enhatls79430	enhancer	E2758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11964	0.61803		ARSG	chr17	68259181	68422731	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7264
enhrx-57408	chr15	70433033	70433034	70140694	70140695	8170	hg38	N/A	enh16282	fant48714	Enhatls61772	enhancer	E2759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064927	0.61803		TLE3	chr15	70047789	70098176	42417	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-103162	chr20	30292521	30292522	31704718	31704719	8171	hg38	N/A	enh19573	fant58365	Enhatls110296	enhancer	E2760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10474	0.61803		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-169125	chr9	134422221	134422222	131546834	131546835	8172	hg38	N/A	N/A	N/A	Enhatls181037	enhancer	E2761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081507	0.61803		PRRT1B	chr9	131545522	131559815	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6392
enhrx-3877	chr1	33722585	33722586	33256984	33256985	8173	hg38	"hs917,hs917"	N/A	N/A	Enhatls4304	enhancer	E2762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093504	0.61803		ZNF362	chr1	33256491	33300719	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3876
enhrx-33856	chr11	120155186	120155187	120284477	120284478	8174	hg38	N/A	enh14328	N/A	Enhatls36734	enhancer	E2763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16242	0.61803		POU2F3	chr11	120236639	120319945	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8525
enhrx-88258	chr2	6078904	6078905	5938772	5938773	8175	hg38	N/A	enh18222	N/A	Enhatls94515	enhancer	E2764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097706	0.61803		SOX11	chr2	5692383	5701385	234029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	184
enhrx-107929	chr21	46750181	46750182	45330266	45330267	8176	hg38	N/A	enh20038	fant60538	Enhatls115421	enhancer	E2765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021513	0.61803		POFUT2	chr21	45263927	45287898	42129	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1812
enhrx-59308	chr15	93197574	93197575	92654344	92654345	8177	hg38	N/A	N/A	N/A	Enhatls63859	enhancer	E2766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15316	0.61803		FAM174B	chr15	92617447	92809798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6010
enhrx-56480	chr15	59458074	59458075	59165875	59165876	8178	hg38	N/A	enh16187	N/A	Enhatls60767	enhancer	E2767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0077279	0.61803		MYO1E	chr15	59132433	59372871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3182
enhrx-17184	chr1	242143453	242143454	241980151	241980152	8179	hg38	N/A	N/A	N/A	Enhatls18803	enhancer	E2768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032685	0.61803		MAP1LC3C	chr1	241995489	241999098	11586	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17183
enhrx-121845	chr3	189431092	189431093	189713303	189713304	8180	hg38	N/A	enh36256	N/A	Enhatls130398	enhancer	E2769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0733	0.61881		TP63	chr3	189631388	189897276	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9974
enhrx-173517	chrX	69440389	69440390	70220539	70220540	8181	hg38	N/A	enh57386	N/A	Enhatls185689	enhancer	E2770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10379	0.61898		AWAT1	chrX	70234654	70240659	11990	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3234
enhrx-117548	chr3	112822674	112822675	113103827	113103828	8182	hg38	N/A	enh57843	N/A	Enhatls125807	enhancer	E2771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070671	0.61898		NEPRO	chr3	113002443	113019733	81885	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5677
enhrx-129024	chr4	154731727	154731728	153810575	153810576	8183	hg38	N/A	enh71497	N/A	Enhatls137941	enhancer	E2772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058519	0.61983		SFRP2	chr4	153780590	153789083	20746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6568
enhrx-22106	chr10	93450392	93450393	91690635	91690636	8184	hg38	N/A	enh62080	N/A	Enhatls24316	enhancer	E2773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11717	0.61983		PPP1R3C	chr10	91628441	91633071	54752	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4541
enhrx-1594	chr1	13926333	13926334	13599838	13599839	8185	hg38	N/A	enh26537	N/A	Enhatls1771	enhancer	E2774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12587	0.61983		PDPN	chr1	13583464	13617957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1593
enhrx-34362	chr11	126203190	126203191	126333295	126333296	8186	hg38	N/A	enh14373	N/A	Enhatls37270	enhancer	E2775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058517	0.62047		DCPS	chr11	126304059	126350005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9031
enhrx-58840	chr15	88006209	88006210	87462978	87462979	8187	hg38	N/A	enh81054	N/A	Enhatls63365	enhancer	E2776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021002	0.62047		NTRK3	chr15	87859750	88256791	394727	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5542
enhrx-15542	chr1	216774164	216774165	216600822	216600823	8188	hg38	N/A	enh98607	N/A	Enhatls17076	enhancer	E2777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00023988	0.62047		ESRRG	chr1	216503245	217137755	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15541
enhrx-90701	chr2	48449221	48449222	48222082	48222083	8189	hg38	N/A	enh53058	N/A	Enhatls97181	enhancer	E2778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03235	0.62047		FOXN2	chr2	48314636	48379295	89821	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2627
enhrx-112641	chr3	14186258	14186259	14144758	14144759	8190	hg38	N/A	enh115770	N/A	Enhatls120534	enhancer	E2779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14996	0.62075		XPC	chr3	14145146	14178621	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	770
enhrx-161618	chr8	126704920	126704921	125692676	125692677	8191	hg38	N/A	enh25296	N/A	Enhatls172611	enhancer	E2780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05849	0.62076		TRIB1	chr8	125430357	125438403	245441	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5409
enhrx-65686	chr16	75098559	75098560	75064661	75064662	8192	hg38	N/A	enh4129	N/A	Enhatls70485	enhancer	E2781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051425	0.62076		ZNRF1	chr16	74999023	75110994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5981
enhrx-115863	chr3	57144022	57144023	57109994	57109995	8193	hg38	N/A	enh111043	N/A	Enhatls123967	enhancer	E2782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0092254	0.62076		IL17RD	chr3	57089981	57170306	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3992
enhrx-83376	chr19	30078538	30078539	29587631	29587632	8194	hg38	N/A	enh44645	N/A	Enhatls89424	enhancer	E2783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21471	0.62076		POP4	chr19	29606282	29617237	16455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4346
enhrx-72421	chr17	47516948	47516949	49439586	49439587	8195	hg38	N/A	enh44440	N/A	Enhatls77737	enhancer	E2784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00056714	0.62076		PHB1	chr17	49404048	49414905	18259	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5690
enhrx-83608	chr19	34322956	34322957	33832051	33832052	8196	hg38	N/A	enh96842	N/A	Enhatls89666	enhancer	E2785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10998	0.62096		KCTD15	chr19	33795932	33815763	14178	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4578
enhrx-88731	chr2	16842939	16842940	16661671	16661672	8197	hg38	N/A	enh5318	N/A	Enhatls95066	enhancer	E2786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018152	0.62096		CYRIA	chr2	16549458	16666331	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	657
enhrx-101242	chr2	241009427	241009428	240070010	240070011	8198	hg38	N/A	enh70214	N/A	Enhatls108290	enhancer	E2787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077157	0.62096		OR6B3	chr2	240044570	240053521	11205	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13168
enhrx-8774	chr1	109925978	109925979	109383356	109383357	8199	hg38	N/A	enh12125	N/A	Enhatls9476	enhancer	E2788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013742	0.62187		SORT1	chr1	109309567	109397918	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8773
enhrx-121715	chr3	186143990	186143991	186426201	186426202	8200	hg38	N/A	enh63251	N/A	Enhatls130247	enhancer	E2789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019975	0.62238		DGKG	chr3	186147200	186362234	61623	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9844
enhrx-2796	chr1	24348151	24348152	24021661	24021662	8201	hg38	N/A	enh11616	N/A	Enhatls3120	enhancer	E2790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076883	0.62238		SRSF10	chr1	23964346	23980356	26360	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2795
enhrx-58361	chr15	81097633	81097634	80805292	80805293	8202	hg38	N/A	enh44168	N/A	Enhatls62782	enhancer	E2791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045478	0.6224		CEMIP	chr15	80779342	80951776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5063
enhrx-32125	chr11	91342058	91342059	91608892	91608893	8203	hg38	N/A	N/A	N/A	Enhatls34895	enhancer	E2792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039804	0.62259		FAT3	chr11	92224817	92896473	587319	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6794
enhrx-135583	chr5	134315312	134315313	134979622	134979623	8204	hg38	N/A	N/A	N/A	Enhatls144839	enhancer	E2793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11235	0.62369		CATSPER3	chr5	134967906	135011696	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5374
enhrx-150360	chr7	70044514	70044515	70579528	70579529	8205	hg38	N/A	enh40252	N/A	Enhatls160736	enhancer	E2794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.064159	0.62369		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3172
enhrx-59437	chr15	99410843	99410844	98867614	98867615	8206	hg38	N/A	enh16459	fant49520	Enhatls64003	enhancer	E2795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13189	0.62399		IGF1R	chr15	98648538	98964530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6139
enhrx-144001	chr6	107135687	107135688	106687812	106687813	8207	hg38	N/A	enh9281	N/A	Enhatls153881	enhancer	E2796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10624	0.62399		QRSL1	chr6	106629577	106668417	15514	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5589
enhrx-29489	chr11	62408358	62408359	62640886	62640887	8208	hg38	N/A	N/A	N/A	Enhatls32045	enhancer	E2797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16366	0.62399		GANAB	chr11	62624825	62646726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4158
enhrx-66088	chr16	84210909	84210910	84177303	84177304	8209	hg38	N/A	enh99362	N/A	Enhatls70942	enhancer	E2798	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11502	0.62399		DNAAF1	chr16	84145307	84178767	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6383
enhrx-148607	chr7	25064968	25064969	25025349	25025350	8210	hg38	N/A	enh9662	fant25872	Enhatls158812	enhancer	E2799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039174	0.624		OSBPL3	chr7	24796539	24981634	43607	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1419
enhrx-6520	chr1	64809292	64809293	64343609	64343610	8211	hg38	N/A	enh11951	N/A	Enhatls7104	enhancer	E2800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095016	0.624		UBE2U	chr1	64203622	64267368	73731	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6519
enhrx-127581	chr4	113034406	113034407	112113250	112113251	8212	hg38	N/A	enh54930	N/A	Enhatls136447	enhancer	E2801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087669	0.62405		FAM241A	chr4	112145453	112195256	29435	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5125
enhrx-17723	chr10	3848874	3848875	3806682	3806683	8213	hg38	N/A	enh1060	fant34426	Enhatls19362	enhancer	E2802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051534	0.62405		KLF6	chr10	3775995	3785281	20948	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	158
enhrx-70111	chr17	31846900	31846901	33519881	33519882	8214	hg38	N/A	enh17113	N/A	Enhatls75245	enhancer	E2803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0017959	0.62405		ASIC2	chr17	33013086	34157294	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3380
enhrx-96366	chr2	163439182	163439183	162582672	162582673	8215	hg38	N/A	enh53396	N/A	Enhatls103158	enhancer	E2804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12437	0.62442		KCNH7	chr2	162371406	162838767	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8292
enhrx-40358	chr12	76100359	76100360	75706579	75706580	8216	hg38	N/A	enh2466	N/A	Enhatls43628	enhancer	E2805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015209	0.62446		KRR1	chr12	75490862	75511609	188486	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5668
enhrx-151714	chr7	92676364	92676365	93047050	93047051	8217	hg38	N/A	enh40406	N/A	Enhatls162183	enhancer	E2806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13252	0.62447		SAMD9	chr7	93099512	93118023	49092	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4526
enhrx-116482	chr3	72770742	72770743	72721591	72721592	8218	hg38	N/A	enh20705	N/A	Enhatls124659	enhancer	E2807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031441	0.62447		SHQ1	chr3	72749276	72861914	17873	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-96034	chr2	159041584	159041585	158185072	158185073	8219	hg38	N/A	enh76440	N/A	Enhatls102802	enhancer	E2808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047258	0.62453		CCDC148	chr2	158171072	158456753	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7960
enhrx-32126	chr11	91855855	91855856	92122689	92122690	8220	hg38	N/A	enh28976	N/A	Enhatls34896	enhancer	E2809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20717	0.62453		FAT3	chr11	92224817	92896473	97209	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6795
enhrx-50782	chr14	68438470	68438471	67971753	67971754	8221	hg38	N/A	enh3298	N/A	Enhatls54763	enhancer	E2810	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05943	0.62453		RAD51B	chr14	67819778	68730218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2739
enhrx-113961	chr3	42172025	42172026	42130533	42130534	8222	hg38	N/A	enh7149	N/A	Enhatls121950	enhancer	E2811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016436	0.62623		TRAK1	chr3	42013801	42225890	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2090
enhrx-132237	chr5	55575972	55575973	56280145	56280146	8223	hg38	N/A	enh37827	fant18549	Enhatls141322	enhancer	E2812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15032	0.62623		ANKRD55	chr5	56099679	56233330	46779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-118564	chr3	126832069	126832070	127113226	127113227	8224	hg38	N/A	enh82723	N/A	Enhatls126874	enhancer	E2813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14297	0.62624		PLXNA1	chr3	126982692	127037389	73454	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6693
enhrx-168051	chr9	126841156	126841157	124078877	124078878	8225	hg38	N/A	enh25990	N/A	Enhatls179865	enhancer	E2814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10048	0.62624		LHX2	chr9	124001669	124033301	37426	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5318
enhrx-159743	chr8	77649334	77649335	76737098	76737099	8226	hg38	N/A	enh78525	N/A	Enhatls170635	enhancer	E2815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090682	0.62624		ZFHX4	chr8	76681246	76867281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3534
enhrx-158469	chr8	41942941	41942942	42085423	42085424	8227	hg38	N/A	enh24964	N/A	Enhatls169301	enhancer	E2816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12233	0.62675		KAT6A	chr8	41929478	42051994	31034	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2260
enhrx-153351	chr7	109513648	109513649	109873591	109873592	8228	hg38	N/A	N/A	N/A	Enhatls163873	enhancer	E2817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14317	0.62675		IMMP2L	chr7	110662643	111562517	717396	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6163
enhrx-90599	chr2	46662265	46662266	46435126	46435127	8229	hg38	N/A	enh18527	fant6947	Enhatls97065	enhancer	E2818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078838	0.62675		TMEM247	chr2	46479564	46484425	44328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2525
enhrx-6770	chr1	68257921	68257922	67792238	67792239	8230	hg38	N/A	enh11965	fant1955	Enhatls7370	enhancer	E2819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040291	0.62675		GNG12	chr1	67701474	67833467	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6769
enhrx-127712	chr4	114567175	114567176	113646019	113646020	8231	hg38	N/A	enh8156	N/A	Enhatls136578	enhancer	E2820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13247	0.62686		CAMK2D	chr4	113451031	113761927	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5256
enhrx-157879	chr8	30284124	30284125	30426608	30426609	8232	hg38	N/A	enh24913	N/A	Enhatls168668	enhancer	E2821	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16295	0.62686		RBPMS	chr8	30384510	30572256	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1670
enhrx-4739	chr1	42346178	42346179	41880507	41880508	8233	hg38	N/A	enh11795	N/A	Enhatls5201	enhancer	E2822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091757	0.62686		HIVEP3	chr1	41506364	41918922	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4738
enhrx-97022	chr2	172917193	172917194	172052465	172052466	8234	hg38	N/A	enh92974	N/A	Enhatls103838	enhancer	E2823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0098449	0.6272		METAP1D	chr2	171999952	172082430	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8948
enhrx-120645	chr3	167532457	167532458	167814669	167814670	8235	hg38	N/A	enh36088	N/A	Enhatls129082	enhancer	E2824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020514	0.6272		SERPINI1	chr3	167735242	167825569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8774
enhrx-113611	chr3	37977955	37977956	37936464	37936465	8236	hg38	N/A	enh20502	N/A	Enhatls121565	enhancer	E2825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053528	0.6272		CTDSPL	chr3	37861879	37984469	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1740
enhrx-22658	chr10	98479215	98479216	96719458	96719459	8237	hg38	N/A	N/A	N/A	Enhatls24908	enhancer	E2826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014873	0.62788		PIK3AP1	chr10	96593314	96720514	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5093
enhrx-100098	chr2	224888147	224888148	224023430	224023431	8238	hg38	N/A	enh48418	N/A	Enhatls107094	enhancer	E2827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064301	0.62914		SERPINE2	chr2	223975044	224039318	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12024
enhrx-13470	chr1	184807980	184807981	184838846	184838847	8239	hg38	N/A	enh808	N/A	Enhatls14875	enhancer	E2828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041127	0.62944		NIBAN1	chr1	184790723	184974508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13469
enhrx-98915	chr2	204895863	204895864	204031140	204031141	8240	hg38	N/A	enh19138	N/A	Enhatls105834	enhancer	E2829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20106	0.62944		ICOS	chr2	203936762	203961577	65823	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10841
enhrx-111103	chr22	43336414	43336415	42940408	42940409	8241	hg38	N/A	enh20236	N/A	Enhatls118887	enhancer	E2830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0014929	0.62944		PACSIN2	chr22	42869767	43015149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2934
enhrx-57425	chr15	71117614	71117615	70825275	70825276	8242	hg38	N/A	enh16296	N/A	Enhatls61790	enhancer	E2831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0051791	0.62944		LARP6	chr15	70829129	70854157	57	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4127
enhrx-132667	chr5	66605351	66605352	67309523	67309524	8243	hg38	N/A	enh22305	N/A	Enhatls141777	enhancer	E2832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017542	0.62944		CD180	chr5	67179612	67196799	109793	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2458
enhrx-113980	chr3	42531990	42531991	42490498	42490499	8244	hg38	N/A	enh7151	N/A	Enhatls121974	enhancer	E2833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13992	0.62944		VIPR1	chr3	42489298	42537573	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2109
enhrx-52432	chr14	95967602	95967603	95501265	95501266	8245	hg38	N/A	enh3416	fant47156	Enhatls56543	enhancer	E2834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048778	0.62944		SYNE3	chr14	95407265	95516650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4389
enhrx-75471	chr17	78680329	78680330	80706529	80706530	8246	hg38	N/A	enh4634	N/A	Enhatls80992	enhancer	E2835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040947	0.62944		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-99574	chr2	217400298	217400299	216535575	216535576	8247	hg38	N/A	enh19216	fant10062	Enhatls106529	enhancer	E2836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11798	0.62959		RPL37A	chr2	216498843	216579180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11500
enhrx-160675	chr8	102458153	102458154	101445925	101445926	8248	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E2837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029162	0.62959		GRHL2	chr8	101492438	101669726	37377	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-135589	chr5	134350129	134350130	135014439	135014440	8249	hg38	N/A	enh8703	N/A	Enhatls144845	enhancer	E2838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.088897	0.62959		CATSPER3	chr5	134967906	135011696	580	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5380
enhrx-149366	chr7	41995629	41995630	41956031	41956032	8250	hg38	N/A	enh63664	N/A	Enhatls159650	enhancer	E2839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018772	0.63042		GLI3	chr7	41960948	42264100	1912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2178
enhrx-105292	chr20	55184599	55184600	56609543	56609544	8251	hg38	N/A	enh19778	N/A	Enhatls112607	enhancer	E2840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066579	0.63042		TFAP2C	chr20	56629305	56639283	17667	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3720
enhrx-105299	chr20	55310511	55310512	56735455	56735456	8252	hg38	N/A	enh70318	N/A	Enhatls112614	enhancer	E2841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036892	0.63042		TFAP2C	chr20	56629305	56639283	89807	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-2738	chr1	23775967	23775968	23449474	23449475	8253	hg38	N/A	enh11610	N/A	Enhatls3036	enhancer	E2842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058849	0.63126		ASAP3	chr1	23428562	23484568	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2737
enhrx-137005	chr5	155211035	155211036	155784025	155784026	8254	hg38	N/A	N/A	N/A	Enhatls146399	enhancer	E2843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.14118	0.63126		SGCD	chr5	155870343	156767788	44349	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6796
enhrx-34966	chr12	2905251	2905252	2796085	2796086	8255	hg38	N/A	N/A	N/A	Enhatls37947	enhancer	E2844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096225	0.63126		FKBP4	chr12	2794969	2805423	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	276
enhrx-50827	chr14	69798514	69798515	69331797	69331798	8256	hg38	N/A	N/A	N/A	Enhatls54819	enhancer	E2845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038566	0.63126		GALNT16	chr14	69259963	69357033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2784
enhrx-27853	chr11	34296402	34296403	34274855	34274856	8257	hg38	N/A	enh13882	N/A	Enhatls30312	enhancer	E2846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091308	0.63126		ABTB2	chr11	34150986	34358010	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2522
enhrx-125609	chr4	72474149	72474150	71608432	71608433	8258	hg38	N/A	enh21568	N/A	Enhatls134373	enhancer	E2847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077061	0.63126		SLC4A4	chr4	71062666	71572087	35364	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3153
enhrx-146569	chr6	159727515	159727516	159306483	159306484	8259	hg38	N/A	N/A	N/A	Enhatls156679	enhancer	E2848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065526	0.63126		FNDC1	chr6	159169399	159272108	29716	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8157
enhrx-30779	chr11	68882562	68882563	69115094	69115095	8260	hg38	N/A	enh47499	fant39060	Enhatls33458	enhancer	E2849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059478	0.63126		TPCN2	chr11	69048931	69136316	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5448
enhrx-171973	chrX	40138170	40138171	40278917	40278918	8261	hg38	N/A	enh26222	fant62312	Enhatls184015	enhancer	E2850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0070427	0.63145		BCOR	chrX	40049814	40177329	101401	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1690
enhrx-21456	chr10	79191078	79191079	77431320	77431321	8262	hg38	N/A	enh28257	N/A	Enhatls23604	enhancer	E2851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033569	0.63171		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-10053	chr1	149980809	149980810	150008860	150008861	8263	hg38	N/A	enh12241	N/A	Enhatls11251	enhancer	E2852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06105	0.63171		OTUD7B	chr1	149937811	150010726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10052
enhrx-25730	chr11	1817954	1817955	1796724	1796725	8264	hg38	N/A	enh62112	N/A	Enhatls28082	enhancer	E2853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086818	0.63171		SYT8	chr11	1828306	1837521	29522	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	399
enhrx-144074	chr6	108545086	108545087	108223882	108223883	8265	hg38	N/A	N/A	N/A	Enhatls153960	enhancer	E2854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017506	0.63171		SNX3	chr6	108211221	108261244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5662
enhrx-7729	chr1	90355890	90355891	89890331	89890332	8266	hg38	N/A	enh484	N/A	Enhatls8367	enhancer	E2855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05958	0.63173		LRRC8D	chr1	89821013	89936611	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7728
enhrx-37658	chr12	46009232	46009233	45615449	45615450	8267	hg38	N/A	enh96290	N/A	Enhatls40776	enhancer	E2856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1647	0.63173		ARID2	chr12	45729705	45908040	112194	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2968
enhrx-116483	chr3	72831756	72831757	72782605	72782606	8268	hg38	N/A	N/A	N/A	Enhatls124660	enhancer	E2857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19598	0.63173		SHQ1	chr3	72749276	72861914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4612
enhrx-31038	chr11	72125806	72125807	72414762	72414763	8269	hg38	N/A	enh14066	N/A	Enhatls33747	enhancer	E2858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080709	0.63173		CLPB	chr11	72285494	72434629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5707
enhrx-106298	chr21	16805651	16805652	15433332	15433333	8270	hg38	N/A	N/A	N/A	Enhatls113652	enhancer	E2859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054546	0.63173		USP25	chr21	15729981	15880064	294012	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-49454	chr14	49994227	49994228	49527509	49527510	8271	hg38	N/A	enh96513	N/A	Enhatls53355	enhancer	E2860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0054292	0.63298		RPS29	chr14	49570983	49598690	40687	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1411
enhrx-116515	chr3	73905433	73905434	73856282	73856283	8272	hg38	N/A	N/A	N/A	Enhatls124695	enhancer	E2861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016695	0.63303		PDZRN3	chr3	73382430	73624941	209724	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4644
enhrx-32447	chr11	101307454	101307455	101436723	101436724	8273	hg38	N/A	enh14227	N/A	Enhatls35232	enhancer	E2862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11959	0.63303		TRPC6	chr11	101451563	101584007	12740	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7116
enhrx-18247	chr10	13845799	13845800	13803799	13803800	8274	hg38	N/A	enh27821	N/A	Enhatls19936	enhancer	E2863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024799	0.63529		FRMD4A	chr10	13643705	14462142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	682
enhrx-6228	chr1	59324261	59324262	58858589	58858590	8275	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	E2864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.21856	0.63582		JUN	chr1	58780790	58784047	50367	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6227
enhrx-161282	chr8	120947234	120947235	119934994	119934995	8276	hg38	N/A	enh10493	N/A	Enhatls172255	enhancer	E2865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13655	0.63582		DEPTOR	chr8	119873716	120050918	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5073
enhrx-167737	chr9	123493108	123493109	120730830	120730831	8277	hg38	N/A	enh10949	N/A	Enhatls179526	enhancer	E2866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092353	0.63582		MEGF9	chr9	120600810	120714470	15431	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5004
enhrx-17628	chr10	993134	993135	947194	947195	8278	hg38	N/A	enh12892	N/A	Enhatls19259	enhancer	E2867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084114	0.63582		LARP4B	chr10	806932	931705	13108	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	63
enhrx-67284	chr17	4065100	4065101	4161806	4161807	8279	hg38	N/A	enh16935	N/A	Enhatls72255	enhancer	E2868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.054417	0.63583		CYB5D2	chr17	4143167	4187310	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	553
enhrx-148633	chr7	26506751	26506752	26467131	26467132	8280	hg38	N/A	N/A	N/A	Enhatls158849	enhancer	E2869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057179	0.63583		SNX10	chr7	26291861	26374383	88313	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1445
enhrx-15108	chr1	208842485	208842486	208669140	208669141	8281	hg38	N/A	N/A	N/A	Enhatls16628	enhancer	E2870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0060495	0.63583		PLXNA2	chr1	208022241	208244384	420307	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15107
enhrx-136126	chr5	141220373	141220374	141840808	141840809	8282	hg38	N/A	enh8738	N/A	Enhatls145423	enhancer	E2871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0082455	0.63607		PCDH1	chr5	141853089	141879246	4429	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5917
enhrx-62185	chr16	22276928	22276929	22265607	22265608	8283	hg38	N/A	N/A	N/A	Enhatls66810	enhancer	E2872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053755	0.63607		EEF2K	chr16	22206277	22288738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2480
enhrx-8875	chr1	110550308	110550309	110007686	110007687	8284	hg38	N/A	N/A	N/A	Enhatls9575	enhancer	E2873	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00014276	0.63607		AHCYL1	chr1	109984764	110023742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8874
enhrx-22514	chr10	97302380	97302381	95542623	95542624	8285	hg38	N/A	enh13422	N/A	Enhatls24757	enhancer	E2874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099883	0.63607		SORBS1	chr10	95311770	95561414	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4949
enhrx-113447	chr3	34417301	34417302	34375809	34375810	8286	hg38	N/A	N/A	N/A	Enhatls121389	enhancer	E2875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087344	0.63607		PDCD6IP	chr3	33798570	33869707	496897	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1576
enhrx-15206	chr1	210710148	210710149	210536804	210536805	8287	hg38	N/A	enh43130	N/A	Enhatls16728	enhancer	E2876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11187	0.63682		HHAT	chr1	210328251	210676296	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15205
enhrx-153251	chr7	107593127	107593128	107952682	107952683	8288	hg38	N/A	N/A	N/A	Enhatls163770	enhancer	E2877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047882	0.63683		LAMB1	chr7	107923798	108003213	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6063
enhrx-136171	chr5	141806087	141806088	142426522	142426523	8289	hg38	N/A	enh8742	N/A	Enhatls145472	enhancer	E2878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077371	0.63683		SPRY4	chr5	142310426	142325021	101466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5962
enhrx-54520	chr15	40391130	40391131	40098929	40098930	8290	hg38	N/A	enh3538	fant47953	Enhatls58716	enhancer	E2879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17442	0.63683		BMF	chr15	40087889	40108892	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1222
enhrx-133314	chr5	76483095	76483096	77187270	77187271	8291	hg38	N/A	enh77657	N/A	Enhatls142434	enhancer	E2880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26205	0.63727		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3105
enhrx-169549	chr9	137661066	137661067	134769220	134769221	8292	hg38	N/A	enh66757	N/A	Enhatls181466	enhancer	E2881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02435	0.63727		COL5A1	chr9	134641802	134844843	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6816
enhrx-90333	chr2	41684392	41684393	41457252	41457253	8293	hg38	N/A	enh18477	N/A	Enhatls96769	enhancer	E2882	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050135	0.63727		PKDCC	chr2	42048020	42058517	587646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2259
enhrx-148226	chr7	17572850	17572851	17533226	17533227	8294	hg38	N/A	enh39922	N/A	Enhatls158403	enhancer	E2883	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18618	0.6377		AHR	chr7	17132189	17346150	178801	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1038
enhrx-138624	chr6	4728068	4728069	4727834	4727835	8295	hg38	N/A	enh46055	N/A	Enhatls148200	enhancer	E2884	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06228	0.6377		CDYL	chr6	4706158	4955551	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	212
enhrx-42874	chr12	117580920	117580921	117143115	117143116	8296	hg38	N/A	N/A	N/A	Enhatls46301	enhancer	E2885	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0043365	0.63853		FBXO21	chr12	117141990	117190470	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8184
enhrx-36863	chr12	27456454	27456455	27303521	27303522	8297	hg38	N/A	enh47567	N/A	Enhatls39956	enhancer	E2886	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068584	0.63857		STK38L	chr12	27243967	27325959	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2173
enhrx-60966	chr16	6010871	6010872	5960870	5960871	8298	hg38	N/A	N/A	N/A	Enhatls65542	enhancer	E2887	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0638	0.63857		RBFOX1	chr16	5239801	7713340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1261
enhrx-23613	chr10	106240719	106240720	104480961	104480962	8299	hg38	N/A	enh96137	N/A	N/A	enhancer	E2888	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032857	0.63921		CFAP58	chr10	104353832	104455102	25031	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6048
enhrx-146399	chr6	157144132	157144133	156822998	156822999	8300	hg38	N/A	enh66301	N/A	Enhatls156482	enhancer	E2889	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11278	0.63921		ARID1B	chr6	156776019	157210779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7987
enhrx-42919	chr12	117956814	117956815	117519009	117519010	8301	hg38	N/A	N/A	N/A	Enhatls46349	enhancer	E2890	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037874	0.63921		KSR2	chr12	117453011	117968990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8229
enhrx-54694	chr15	41138340	41138341	40846142	40846143	8302	hg38	N/A	enh16069	fant47972	Enhatls58889	enhancer	E2891	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096084	0.63921		SPINT1	chr15	40844017	40858207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1396
enhrx-118658	chr3	128428881	128428882	128710038	128710039	8303	hg38	N/A	enh20919	N/A	Enhatls126976	enhancer	E2892	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057476	0.63923		RAB7A	chr3	128693668	128825942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6787
enhrx-66244	chr16	85878448	85878449	85844842	85844843	8304	hg38	N/A	enh47982	N/A	Enhatls71114	enhancer	E2893	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012628	0.6395		COX4I1	chr16	85798632	85807068	35812	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6539
enhrx-76933	chr18	19571154	19571155	21991193	21991194	8305	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	E2894	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034732	0.63952		MIB1	chr18	21740791	21870953	117852	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	951
enhrx-10460	chr1	152020306	152020307	152047830	152047831	8306	hg38	N/A	N/A	N/A	Enhatls11666	enhancer	E2895	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025351	0.63952		S100A11	chr1	152032505	152037004	9154	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10459
enhrx-110445	chr22	38679896	38679897	38283890	38283891	8307	hg38	N/A	enh20206	N/A	Enhatls118199	enhancer	E2896	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017314	0.63952		CSNK1E	chr22	38290690	38318084	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2276
enhrx-30659	chr11	68110314	68110315	68342846	68342847	8308	hg38	N/A	enh14024	fant39027	Enhatls33331	enhancer	E2897	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11859	0.63952		LRP5	chr11	68312590	68449275	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5328
enhrx-140492	chr6	33784799	33784800	33817022	33817023	8309	hg38	N/A	enh77848	N/A	Enhatls150193	enhancer	E2898	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1605	0.63952		MLN	chr6	33794672	33804003	10030	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2080
enhrx-87093	chr19	53426411	53426412	52923158	52923159	8310	hg38	N/A	N/A	N/A	Enhatls93314	enhancer	E2899	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077511	0.63952		ZNF888	chr19	52904414	52923428	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8063
enhrx-2517	chr1	21960913	21960914	21634420	21634421	8311	hg38	N/A	enh11591	N/A	Enhatls2795	enhancer	E2900	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10802	0.63952		RAP1GAP	chr1	21596220	21669357	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2516
enhrx-164545	chr9	38023212	38023213	38023215	38023216	8312	hg38	N/A	enh10763	N/A	Enhatls175685	enhancer	E2901	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036133	0.63952		SHB	chr9	37915897	38069227	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1812
enhrx-142067	chr6	52416395	52416396	52551597	52551598	8313	hg38	N/A	enh23303	N/A	Enhatls151882	enhancer	E2902	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.084453	0.63952		TRAM2	chr6	52497407	52577060	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3655
enhrx-105742	chr20	61382829	61382830	62751477	62751478	8314	hg38	N/A	enh86426	N/A	Enhatls113099	enhancer	E2903	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087322	0.63952		NTSR1	chr20	62708835	62762771	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-121822	chr3	187754377	187754378	188036589	188036590	8315	hg38	N/A	enh7766	fant14562	Enhatls130371	enhancer	E2904	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0027453	0.63952		LPP	chr3	188153283	188890671	116514	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-148829	chr7	30657170	30657171	30617554	30617555	8316	hg38	N/A	N/A	N/A	Enhatls159062	enhancer	E2905	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061048	0.63952		GARS1	chr7	30580532	30634033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1641
enhrx-40822	chr12	88811491	88811492	88417714	88417715	8317	hg38	N/A	enh29822	N/A	Enhatls44112	enhancer	E2906	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076463	0.63952		KITLG	chr12	88492792	88580851	69175	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6132
enhrx-176809	chrX	141164593	141164594	142076807	142076808	8318	hg38	N/A	N/A	N/A	Enhatls189049	enhancer	E2907	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.18871	0.63987		MAGEC2	chrX	142202341	142205290	120928	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6526
enhrx-61834	chr16	20009228	20009229	19997906	19997907	8319	hg38	N/A	N/A	N/A	Enhatls66447	enhancer	E2908	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0052009	0.63987		GPR139	chr16	20028238	20073890	16136	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2129
enhrx-56538	chr15	60685405	60685406	60393206	60393207	8320	hg38	N/A	enh99243	N/A	Enhatls60824	enhancer	E2909	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040849	0.64003		ANXA2	chr15	60347133	60402883	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3240
enhrx-161610	chr8	126322339	126322340	125310097	125310098	8321	hg38	N/A	enh10519	fant30859	Enhatls172605	enhancer	E2910	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088374	0.64003		NSMCE2	chr8	125091678	125367120	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5401
enhrx-102954	chr20	24971538	24971539	24990902	24990903	8322	hg38	N/A	N/A	N/A	Enhatls110079	enhancer	E2911	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010432	0.64094		APMAP	chr20	24962924	24992751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1382
enhrx-49683	chr14	52031904	52031905	51565186	51565187	8323	hg38	N/A	N/A	N/A	Enhatls53608	enhancer	E2912	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032827	0.64094		FRMD6	chr14	51489136	51730727	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-118540	chr3	126472362	126472363	126753519	126753520	8324	hg38	N/A	enh35857	N/A	Enhatls126846	enhancer	E2913	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057536	0.64114		CHCHD6	chr3	126704239	126960420	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6669
enhrx-167726	chr9	123325091	123325092	120562813	120562814	8325	hg38	N/A	enh93835	N/A	Enhatls179517	enhancer	E2914	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05945	0.64114		CDK5RAP2	chr9	120388874	120580167	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4993
enhrx-113807	chr3	39020387	39020388	38978896	38978897	8326	hg38	N/A	N/A	N/A	Enhatls121784	enhancer	E2915	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00010976	0.64114		SCN11A	chr3	38845763	39051944	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1936
enhrx-137697	chr5	174089225	174089226	174662222	174662223	8327	hg38	N/A	N/A	N/A	Enhatls147175	enhancer	E2916	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19573	0.64124		MSX2	chr5	174724581	174730896	46140	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-93387	chr2	100253266	100253267	99636804	99636805	8328	hg38	N/A	enh5728	N/A	Enhatls100016	enhancer	E2917	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076214	0.6422		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5313
enhrx-34586	chr11	133469755	133469756	133599860	133599861	8329	hg38	N/A	N/A	N/A	Enhatls37528	enhancer	E2918	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047123	0.64342		OPCML	chr11	132414976	133532501	27278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9255
enhrx-74889	chr17	74170349	74170350	76174268	76174269	8330	hg38	N/A	N/A	N/A	Enhatls80371	enhancer	E2919	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019006	0.64342		RNF157	chr17	76142464	76240493	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8158
enhrx-167657	chr9	119336798	119336799	116574519	116574520	8331	hg38	N/A	enh57146	N/A	Enhatls179442	enhancer	E2920	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056409	0.64342		ASTN2	chr9	116423111	117415070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4924
enhrx-109055	chr22	24699494	24699495	24303526	24303527	8332	hg38	N/A	N/A	N/A	Enhatls116691	enhancer	E2921	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016488	0.64342		SPECC1L	chr22	24270816	24417739	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	886
enhrx-58963	chr15	89861148	89861149	89317917	89317918	8333	hg38	N/A	N/A	N/A	Enhatls63495	enhancer	E2922	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08017	0.64342		POLG	chr15	89305197	89334861	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5665
enhrx-14585	chr1	204288837	204288838	204319709	204319710	8334	hg38	N/A	enh12578	N/A	Enhatls16058	enhancer	E2923	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026502	0.64342		PLEKHA6	chr1	204218852	204377665	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14584
enhrx-143382	chr6	88284126	88284127	87574408	87574409	8335	hg38	N/A	enh39232	N/A	Enhatls153254	enhancer	E2924	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033887	0.64376		RARS2	chr6	87513762	87590028	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4970
enhrx-91369	chr2	64694075	64694076	64466941	64466942	8336	hg38	N/A	N/A	N/A	Enhatls97899	enhancer	E2925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17879	0.64406		LGALSL	chr2	64453968	64461381	4681	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3295
enhrx-159469	chr8	69611801	69611802	68699566	68699567	8337	hg38	N/A	enh73302	N/A	Enhatls170335	enhancer	E2926	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14101	0.64406		C8orf34	chr8	68330954	68819023	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3260
enhrx-154888	chr7	139938954	139938955	140239154	140239155	8338	hg38	N/A	enh24585	N/A	Enhatls165516	enhancer	E2927	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071516	0.64435		KDM7A	chr7	140084745	140176983	59943	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7700
enhrx-123673	chr4	17702736	17702737	17701113	17701114	8339	hg38	N/A	N/A	N/A	Enhatls132355	enhancer	E2928	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081515	0.64614		FAM184B	chr4	17629305	17781621	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-116482	chr3	72793684	72793685	72744533	72744534	8340	hg38	N/A	enh54199	N/A	Enhatls124659	enhancer	E2929	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060841	0.64614		SHQ1	chr3	72749276	72861914	253	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-59128	chr15	90944237	90944238	90401005	90401006	8341	hg38	N/A	enh3791	fant49320	Enhatls63671	enhancer	E2930	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029095	0.64655		IQGAP1	chr15	90388241	90502239	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5830
enhrx-4281	chr1	37964948	37964949	37499347	37499348	8342	hg38	N/A	enh26633	N/A	Enhatls4719	enhancer	E2931	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075247	0.64676		MEAF6	chr1	37489992	37514766	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4280
enhrx-65845	chr16	78291471	78291472	78257574	78257575	8343	hg38	N/A	enh92692	N/A	Enhatls70656	enhancer	E2932	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076591	0.64701		WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6140
enhrx-63177	chr16	31140389	31140390	31129068	31129069	8344	hg38	N/A	N/A	fant50422	Enhatls67857	enhancer	E2933	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051076	0.64701		KAT8	chr16	31114488	31131393	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3472
enhrx-60992	chr16	8222631	8222632	8172629	8172630	8345	hg38	N/A	N/A	N/A	Enhatls65568	enhancer	E2934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00059395	0.64702		TMEM114	chr16	8569499	8590511	388657	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1287
enhrx-105221	chr20	52765693	52765694	54149154	54149155	8346	hg38	N/A	enh53796	N/A	Enhatls112538	enhancer	E2935	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04387	0.64743		CYP24A1	chr20	54153445	54173986	151	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3649
enhrx-13122	chr1	180126945	180126946	180157810	180157811	8347	hg38	N/A	enh12422	N/A	Enhatls14487	enhancer	E2936	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055043	0.64743		QSOX1	chr1	180154868	180204030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13121
enhrx-162824	chr9	747692	747693	747692	747693	8348	hg38	N/A	enh25412	N/A	Enhatls173892	enhancer	E2937	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015691	0.64743		KANK1	chr9	470290	746105	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	91
enhrx-46235	chr13	51699829	51699830	51125693	51125694	8349	hg38	N/A	enh68418	N/A	Enhatls49924	enhancer	E2938	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17448	0.6476		C13orf42	chr13	51082118	51111274	12600	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1857
enhrx-16939	chr1	237008487	237008488	236845187	236845188	8350	hg38	N/A	enh92170	N/A	Enhatls18540	enhancer	E2939	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12844	0.6476		MTR	chr1	236795291	236903981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16938
enhrx-65846	chr16	78331108	78331109	78297211	78297212	8351	hg38	N/A	enh52331	N/A	Enhatls70657	enhancer	E2940	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11967	0.6476		WWOX	chr16	78099399	79212667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6141
enhrx-133667	chr5	82003108	82003109	82707289	82707290	8352	hg38	N/A	enh83776	N/A	Enhatls142796	enhancer	E2941	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07594	0.6476		TMEM167A	chr5	83052845	83077394	342850	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3458
enhrx-112596	chr3	13538025	13538026	13496525	13496526	8353	hg38	N/A	N/A	N/A	Enhatls120486	enhancer	E2942	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071868	0.6476		HDAC11	chr3	13479723	13506424	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	725
enhrx-35058	chr12	4140681	4140682	4031515	4031516	8354	hg38	N/A	enh14470	fant40716	Enhatls38048	enhancer	E2943	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014993	0.6476		PARP11	chr12	3808860	3873448	157569	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	368
enhrx-33451	chr11	117399323	117399324	117528608	117528609	8355	hg38	N/A	enh47528	N/A	Enhatls36305	enhancer	E2944	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035129	0.6476		DSCAML1	chr11	117427771	117817525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8120
enhrx-80175	chr19	5132450	5132451	5132439	5132440	8356	hg38	N/A	N/A	N/A	Enhatls86013	enhancer	E2945	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.003692	0.64844		KDM4B	chr19	4969112	5153598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1145
enhrx-94229	chr2	113360691	113360692	112603114	112603115	8357	hg38	N/A	enh18813	N/A	Enhatls100906	enhancer	E2946	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084774	0.64844		CHCHD5	chr2	112584594	112589275	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6155
enhrx-126517	chr4	87752710	87752711	86831557	86831558	8358	hg38	N/A	N/A	N/A	Enhatls135335	enhancer	E2947	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0073453	0.64844		SLC10A6	chr4	86823467	86849384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4061
enhrx-66798	chr17	858119	858120	954879	954880	8359	hg38	N/A	enh32038	N/A	Enhatls71717	enhancer	E2948	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.25023	0.64844		NXN	chr17	799309	979776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	67
enhrx-30810	chr11	69881019	69881020	70034913	70034914	8360	hg38	N/A	N/A	N/A	Enhatls33500	enhancer	E2949	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04013	0.64844		ANO1	chr11	69985906	70189530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5479
enhrx-167083	chr9	112969495	112969496	110207215	110207216	8361	hg38	N/A	N/A	N/A	Enhatls178832	enhancer	E2950	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11633	0.64844		C9orf152	chr9	110199560	110208159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4350
enhrx-63738	chr16	50665356	50665357	50631445	50631446	8362	hg38	N/A	N/A	N/A	Enhatls68425	enhancer	E2951	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047315	0.64844		NKD1	chr16	50548395	50649249	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4033
enhrx-60255	chr16	2108355	2108356	2058354	2058355	8363	hg38	N/A	N/A	N/A	Enhatls64806	enhancer	E2952	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12111	0.64844		TSC2	chr16	2047976	2089491	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	550
enhrx-124900	chr4	56223468	56223469	55357301	55357302	8364	hg38	N/A	enh63311	N/A	Enhatls133640	enhancer	E2953	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096277	0.64844		SRD5A3	chr4	55346212	55373100	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2444
enhrx-66962	chr17	1849047	1849048	1945753	1945754	8365	hg38	N/A	enh65004	N/A	Enhatls71906	enhancer	E2954	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013418	0.64844		RTN4RL1	chr17	1934676	2025334	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	231
enhrx-109709	chr22	31451777	31451778	31055791	31055792	8366	hg38	N/A	enh20131	N/A	Enhatls117385	enhancer	E2955	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06168	0.64844		SMTN	chr22	31064104	31104624	5056	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1540
enhrx-33825	chr11	119461476	119461477	119590764	119590765	8367	hg38	N/A	enh29190	fant40107	Enhatls36700	enhancer	E2956	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036283	0.64844		NECTIN1	chr11	119623407	119729200	32371	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8494
enhrx-123997	chr4	35480416	35480417	35478794	35478795	8368	hg38	N/A	N/A	N/A	Enhatls132696	enhancer	E2957	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061773	0.64844		ARAP2	chr4	36066003	36244514	567081	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1541
enhrx-132667	chr5	67048013	67048014	67752185	67752186	8369	hg38	N/A	enh22307	N/A	Enhatls141777	enhancer	E2958	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044705	0.64844		PIK3R1	chr5	68215740	68301821	461454	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2458
enhrx-161143	chr8	116703927	116703928	115691701	115691702	8370	hg38	N/A	enh98198	N/A	Enhatls172101	enhancer	E2959	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061617	0.64899		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4934
enhrx-72923	chr17	55449636	55449637	57372275	57372276	8371	hg38	N/A	enh17241	N/A	Enhatls78277	enhancer	E2960	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27238	0.64909		MSI2	chr17	57255850	57684689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6192
enhrx-145087	chr6	130433327	130433328	130112182	130112183	8372	hg38	N/A	N/A	N/A	Enhatls155042	enhancer	E2961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04228	0.64928		L3MBTL3	chr6	130013698	130141449	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6675
enhrx-170743	chrX	9757149	9757150	9789109	9789110	8373	hg38	N/A	N/A	N/A	Enhatls182709	enhancer	E2962	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0097129	0.64928		SHROOM2	chrX	9786428	9949443	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	460
enhrx-90518	chr2	44314564	44314565	44087425	44087426	8374	hg38	N/A	enh69654	N/A	Enhatls96972	enhancer	E2963	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16311	0.64928		PPM1B	chr2	44167968	44234646	75193	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2444
enhrx-41727	chr12	104765325	104765326	104371547	104371548	8375	hg38	N/A	enh14944	N/A	Enhatls45092	enhancer	E2964	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040688	0.64976		TXNRD1	chr12	104215778	104350307	19101	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7037
enhrx-113863	chr3	39758414	39758415	39716923	39716924	8376	hg38	N/A	enh45380	N/A	Enhatls121849	enhancer	E2965	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15289	0.64976		MYRIP	chr3	39808913	40260321	87886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1992
enhrx-131121	chr5	31706326	31706327	31706219	31706220	8377	hg38	N/A	N/A	N/A	Enhatls140149	enhancer	E2966	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0037224	0.65004		PDZD2	chr5	31639130	32110932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	912
enhrx-35846	chr12	9950740	9950741	9798144	9798145	8378	hg38	N/A	enh14517	N/A	Enhatls38882	enhancer	E2967	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057491	0.65013		KLRF1	chr12	9827480	9845007	27222	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1156
enhrx-40997	chr12	94990573	94990574	94596797	94596798	8379	hg38	N/A	enh14909	N/A	Enhatls44316	enhancer	E2968	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08484	0.65095		TMCC3	chr12	94567121	94650557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6307
enhrx-139171	chr6	18989315	18989316	18989084	18989085	8380	hg38	N/A	enh84106	N/A	Enhatls148782	enhancer	E2969	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16129	0.65095		RNF144B	chr6	18387349	18468870	514225	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	759
enhrx-125975	chr4	77447852	77447853	76526699	76526700	8381	hg38	N/A	enh36734	N/A	Enhatls134770	enhancer	E2970	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074281	0.65121		SHROOM3	chr4	76435228	76783253	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3519
enhrx-93694	chr2	106346914	106346915	105730457	105730458	8382	hg38	N/A	enh53218	N/A	Enhatls100344	enhancer	E2971	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17038	0.65129		NCK2	chr2	105744911	105894274	7419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5620
enhrx-49848	chr14	55092236	55092237	54625518	54625519	8383	hg38	N/A	enh15629	N/A	Enhatls53782	enhancer	E2972	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086397	0.65129		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1805
enhrx-17566	chr10	136292	136293	90352	90353	8384	hg38	N/A	enh12882	N/A	Enhatls19189	enhancer	E2973	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10905	0.65129		TUBB8	chr10	46887	74163	11143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1
enhrx-15329	chr1	212640456	212640457	212467114	212467115	8385	hg38	N/A	enh913	N/A	Enhatls16858	enhancer	E2974	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13959	0.65129		NENF	chr1	212432919	212446379	15305	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15328
enhrx-160655	chr8	101675937	101675938	100663709	100663710	8386	hg38	N/A	N/A	N/A	Enhatls171598	enhancer	E2975	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22533	0.65156		SNX31	chr8	100572888	100663415	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4446
enhrx-175396	chrX	107505047	107505048	108261817	108261818	8387	hg38	N/A	enh60062	N/A	Enhatls187582	enhancer	E2976	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011208	0.65256		COL4A6	chrX	108155606	108439472	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5113
enhrx-116484	chr3	72869765	72869766	72820614	72820615	8388	hg38	N/A	enh7335	N/A	Enhatls124664	enhancer	E2977	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0078427	0.65256		SHQ1	chr3	72749276	72861914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4613
enhrx-120676	chr3	168608946	168608947	168891158	168891159	8389	hg38	N/A	enh21085	N/A	Enhatls129123	enhancer	E2978	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0000445	0.65282		MECOM	chr3	169083498	169663775	191592	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8805
enhrx-112862	chr3	16102034	16102035	16060527	16060528	8390	hg38	N/A	enh20381	fant11344	Enhatls120765	enhancer	E2979	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25042	0.65282		GALNT15	chr3	16174679	16231992	114004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	991
enhrx-123803	chr4	24438744	24438745	24437121	24437122	8391	hg38	N/A	N/A	N/A	Enhatls132487	enhancer	E2980	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18948	0.65282		DHX15	chr4	24527474	24584554	59613	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1347
enhrx-161610	chr8	126265428	126265429	125253186	125253187	8392	hg38	N/A	enh10518	N/A	Enhatls172605	enhancer	E2981	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051361	0.65282		NSMCE2	chr8	125091678	125367120	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5401
enhrx-46304	chr13	52572310	52572311	51998174	51998175	8393	hg38	N/A	enh15353	N/A	Enhatls49999	enhancer	E2982	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062452	0.65335		ATP7B	chr13	51932668	52011590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1926
enhrx-51730	chr14	82161002	82161003	81694658	81694659	8394	hg38	N/A	N/A	N/A	Enhatls55787	enhancer	E2983	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033559	0.65388		SEL1L	chr14	81471546	81533853	94214	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3687
enhrx-140597	chr6	35128720	35128721	35160943	35160944	8395	hg38	N/A	N/A	N/A	Enhatls150305	enhancer	E2984	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019903	0.65388		TCP11	chr6	35118070	35148610	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2185
enhrx-50292	chr14	62027119	62027120	61560401	61560402	8396	hg38	N/A	enh3258	N/A	Enhatls54257	enhancer	E2985	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1388	0.65388		PRKCH	chr14	61187558	61550976	9142	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2249
enhrx-159804	chr8	81446718	81446719	80534483	80534484	8397	hg38	N/A	enh78535	N/A	Enhatls170705	enhancer	E2986	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029059	0.65467		ZBTB10	chr8	80485618	80526265	3366	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3595
enhrx-21512	chr10	80654752	80654753	78894995	78894996	8398	hg38	N/A	enh96105	N/A	Enhatls23668	enhancer	E2987	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05551	0.65504		ZMIZ1	chr10	79068965	79316519	171928	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-15425	chr1	214613055	214613056	214439712	214439713	8399	hg38	N/A	enh917	fant4774	Enhatls16957	enhancer	E2988	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021489	0.6555		PTPN14	chr1	214348699	214551602	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15424
enhrx-118353	chr3	124572430	124572431	124853583	124853584	8400	hg38	N/A	enh35848	N/A	Enhatls126642	enhancer	E2989	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09901	0.65576		ITGB5	chr3	124761947	124901418	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6482
enhrx-17082	chr1	240276254	240276255	240112954	240112955	8401	hg38	N/A	N/A	N/A	Enhatls18694	enhancer	E2990	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050658	0.65583		FMN2	chr1	240014347	240475187	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17081
enhrx-170663	chrX	7038716	7038717	7120675	7120676	8402	hg38	N/A	enh57192	N/A	Enhatls182628	enhancer	E2991	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086056	0.65605		PUDP	chrX	7048919	7148158	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	380
enhrx-77759	chr18	43382765	43382766	45802800	45802801	8403	hg38	N/A	enh4820	N/A	Enhatls83432	enhancer	E2992	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0049028	0.65605		EPG5	chr18	45800580	45967329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1777
enhrx-61605	chr16	17299586	17299587	17205729	17205730	8404	hg38	N/A	enh44263	N/A	Enhatls66214	enhancer	E2993	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045996	0.65605		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1900
enhrx-132391	chr5	60600947	60600948	61305120	61305121	8405	hg38	N/A	enh22274	fant18691	Enhatls141489	enhancer	E2994	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067725	0.65623		ZSWIM6	chr5	61332257	61546172	26883	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2182
enhrx-56369	chr15	57892531	57892532	57600333	57600334	8406	hg38	N/A	N/A	N/A	Enhatls60650	enhancer	E2995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079256	0.65623		MYZAP	chr15	57591903	57685364	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3071
enhrx-56369	chr15	57892531	57892532	57600333	57600334	8407	hg38	N/A	N/A	N/A	Enhatls60650	enhancer	E2995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079256	0.65623		GCOM1	chr15	57591907	57714745	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3071
enhrx-150675	chr7	73898209	73898210	74483879	74483880	8408	hg38	N/A	enh24248	N/A	Enhatls161057	enhancer	E2996	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0538	0.65819		GTF2IRD1	chr7	74453789	74602605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3487
enhrx-21455	chr10	79065622	79065623	77305864	77305865	8409	hg38	N/A	N/A	N/A	Enhatls23603	enhancer	E2997	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035053	0.65849		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-55600	chr15	46865609	46865610	46573411	46573412	8410	hg38	N/A	N/A	N/A	Enhatls59819	enhancer	E2998	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086367	0.65849		SEMA6D	chr15	47184100	47774228	550714	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2302
enhrx-167889	chr9	124704862	124704863	121942583	121942584	8411	hg38	N/A	enh10961	fant33577	Enhatls179702	enhancer	E2999	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012968	0.65849		TTLL11	chr9	121815673	122093606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-170663	chrX	7050584	7050585	7132543	7132544	8412	hg38	N/A	enh11096	N/A	Enhatls182628	enhancer	E3000	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036968	0.65849		PUDP	chrX	7048919	7148158	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	380
enhrx-132071	chr5	53967019	53967020	54671190	54671191	8413	hg38	N/A	enh22223	N/A	Enhatls141155	enhancer	E3001	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060386	0.65883		SNX18	chr5	54517758	54546586	124010	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1862
enhrx-26856	chr11	14929061	14929062	14907515	14907516	8414	hg38	N/A	N/A	N/A	Enhatls29277	enhancer	E3002	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088874	0.65883		CALCB	chr11	14904996	15082342	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1525
enhrx-40358	chr12	76315926	76315927	75922146	75922147	8415	hg38	N/A	enh96323	N/A	Enhatls43628	enhancer	E3003	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01696	0.65948		PHLDA1	chr12	76025446	76031776	101292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5668
enhrx-35441	chr12	7113523	7113524	7006218	7006219	8416	hg38	N/A	enh2166	N/A	Enhatls38472	enhancer	E3004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023706	0.65948		LPCAT3	chr12	6976184	7018476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	751
enhrx-35441	chr12	7113523	7113524	7006218	7006219	8417	hg38	N/A	enh2166	N/A	Enhatls38472	enhancer	E3004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023706	0.65948		C1S	chr12	6988258	7071032	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	751
enhrx-46919	chr13	81456467	81456468	80882332	80882333	8418	hg38	N/A	enh80622	N/A	Enhatls50658	enhancer	E3005	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10862	0.6596		SPRY2	chr13	80335975	80341126	538039	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-163165	chr9	7385924	7385925	7385924	7385925	8419	hg38	N/A	N/A	N/A	Enhatls174240	enhancer	E3006	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053712	0.6596		KDM4C	chr9	6720862	7175648	204328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	432
enhrx-94360	chr2	114564343	114564344	113806766	113806767	8420	hg38	N/A	enh53244	N/A	Enhatls101049	enhancer	E3007	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048492	0.6596		SLC35F5	chr2	113706708	113756642	47987	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6286
enhrx-113037	chr3	23145328	23145329	23103837	23103838	8421	hg38	N/A	N/A	N/A	Enhatls120948	enhancer	E3008	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018054	0.66105		UBE2E2	chr3	23203019	23591794	97766	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1166
enhrx-138650	chr6	5334030	5334031	5333797	5333798	8422	hg38	N/A	enh55620	N/A	Enhatls148227	enhancer	E3009	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26689	0.66105		FARS2	chr6	5261043	5771583	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	238
enhrx-106324	chr21	17394216	17394217	16021896	16021897	8423	hg38	N/A	enh113036	N/A	Enhatls113678	enhancer	E3010	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025358	0.66105		USP25	chr21	15729981	15880064	138902	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	207
enhrx-24104	chr10	117902999	117903000	116143488	116143489	8424	hg38	N/A	enh96151	N/A	Enhatls26459	enhancer	E3011	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047889	0.66105		GFRA1	chr10	116056924	116276803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6539
enhrx-4555	chr1	40318755	40318756	39853083	39853084	8425	hg38	N/A	N/A	N/A	Enhatls5008	enhancer	E3012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092828	0.66105		TRIT1	chr1	39838109	39883506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4554
enhrx-13237	chr1	182110372	182110373	182141237	182141238	8426	hg38	N/A	enh12436	N/A	Enhatls14609	enhancer	E3013	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097807	0.66105		ZNF648	chr1	182054569	182061712	78859	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-153435	chr7	112121977	112121978	112481922	112481923	8427	hg38	N/A	enh66450	N/A	Enhatls163956	enhancer	E3014	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013618	0.66105		LSMEM1	chr7	112480852	112491062	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6247
enhrx-161760	chr8	133059218	133059219	132046971	132046972	8428	hg38	N/A	N/A	N/A	Enhatls172793	enhancer	E3015	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17625	0.66105		OC90	chr8	132024215	132059382	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5551
enhrx-90653	chr2	47419172	47419173	47192033	47192034	8429	hg38	N/A	enh18541	fant6985	Enhatls97125	enhancer	E3016	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078402	0.66281		CALM2	chr2	47160083	47176921	14908	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2579
enhrx-43871	chr12	125312477	125312478	124827931	124827932	8430	hg38	N/A	enh2677	N/A	Enhatls47362	enhancer	E3017	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031345	0.66281		SCARB1	chr12	124776855	124863921	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9181
enhrx-44197	chr12	132663606	132663607	132179061	132179062	8431	hg38	N/A	enh2701	N/A	Enhatls47717	enhancer	E3018	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027821	0.66293		GALNT9	chr12	132196371	132329589	13842	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9507
enhrx-34339	chr11	125950174	125950175	126080279	126080280	8432	hg38	N/A	enh47535	N/A	Enhatls37246	enhancer	E3019	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13264	0.66293		CDON	chr11	125955795	126063335	14036	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-42192	chr12	110221898	110221899	109784093	109784094	8433	hg38	N/A	N/A	N/A	Enhatls45581	enhancer	E3020	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08327	0.66294		TRPV4	chr12	109783086	109833398	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7502
enhrx-107522	chr21	43758283	43758284	42338174	42338175	8434	hg38	N/A	enh53881	N/A	Enhatls114968	enhancer	E3021	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099969	0.66295		TFF2	chr21	42346356	42350994	5731	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1405
enhrx-22288	chr10	95205553	95205554	93445796	93445797	8435	hg38	N/A	enh13411	fant36599	Enhatls24515	enhancer	E3022	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083539	0.66295		MYOF	chr10	93306428	93482334	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4723
enhrx-138779	chr6	8084004	8084005	8083771	8083772	8436	hg38	N/A	enh38771	N/A	Enhatls148365	enhancer	E3023	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097566	0.66295		EEF1E1	chr6	8073359	8102559	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	367
enhrx-154757	chr7	138760762	138760763	139076016	139076017	8437	hg38	N/A	N/A	N/A	Enhatls165388	enhancer	E3024	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063595	0.66295		ZC3HAV1	chr7	139043514	139132122	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7569
enhrx-78109	chr18	50064478	50064479	52538108	52538109	8438	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	E3025	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021613	0.66295		DCC	chr18	52340196	53535899	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2127
enhrx-7252	chr1	81898639	81898640	81432954	81432955	8439	hg38	N/A	enh11986	N/A	Enhatls7868	enhancer	E3026	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11507	0.66317		ADGRL2	chr1	81306165	81993932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7251
enhrx-54121	chr15	33263634	33263635	32971433	32971434	8440	hg38	N/A	N/A	N/A	Enhatls58293	enhancer	E3027	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032156	0.66317		FMN1	chr15	32765543	33194714	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	823
enhrx-62557	chr16	27607011	27607012	27595690	27595691	8441	hg38	N/A	enh88233	N/A	Enhatls67214	enhancer	E3028	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046678	0.66387		KATNIP	chr16	27550143	27780344	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2852
enhrx-10786	chr1	154390935	154390936	154418459	154418460	8442	hg38	N/A	enh12276	N/A	Enhatls11992	enhancer	E3029	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035091	0.66402		IL6R	chr1	154405192	154469450	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10785
enhrx-14540	chr1	203901360	203901361	203932232	203932233	8443	hg38	N/A	enh12570	N/A	Enhatls16004	enhancer	E3030	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058495	0.66409		SNRPE	chr1	203861598	203871152	52306	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14539
enhrx-35197	chr12	6198467	6198468	6089301	6089302	8444	hg38	N/A	enh14487	fant40772	Enhatls38199	enhancer	E3031	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041376	0.66496		VWF	chr12	5948876	6124670	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	507
enhrx-152919	chr7	103032732	103032733	103392285	103392286	8445	hg38	N/A	N/A	N/A	Enhatls163424	enhancer	E3032	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011254	0.66536		SLC26A5	chr7	103352729	103446207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5731
enhrx-69950	chr17	29822777	29822778	31495759	31495760	8446	hg38	N/A	enh4360	N/A	Enhatls75087	enhancer	E3033	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09228	0.66536		RAB11FIP4	chr17	31391674	31538211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3219
enhrx-19296	chr10	33299142	33299143	33010214	33010215	8447	hg38	N/A	N/A	fant35373	Enhatls21086	enhancer	E3034	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00036209	0.66536		ITGB1	chr10	32887272	32992463	17703	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1731
enhrx-146134	chr6	152053171	152053172	151732036	151732037	8448	hg38	N/A	enh9455	N/A	Enhatls156206	enhancer	E3035	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10452	0.66543		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7722
enhrx-116482	chr3	72796344	72796345	72747193	72747194	8449	hg38	N/A	enh54199	N/A	Enhatls124659	enhancer	E3036	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2766	0.66543		SHQ1	chr3	72749276	72861914	253	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-112564	chr3	13148287	13148288	13106787	13106788	8450	hg38	N/A	enh48626	N/A	Enhatls120450	enhancer	E3037	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035436	0.66543		IQSEC1	chr3	12897042	13283281	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	693
enhrx-4742	chr1	42601207	42601208	42135536	42135537	8451	hg38	N/A	N/A	N/A	Enhatls5203	enhancer	E3038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10921	0.66543		GUCA2B	chr1	42153409	42155820	12136	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4741
enhrx-32397	chr11	99808301	99808302	99937569	99937570	8452	hg38	N/A	N/A	N/A	Enhatls35180	enhancer	E3039	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.002698	0.66582		CNTN5	chr11	99020948	100358885	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7066
enhrx-105739	chr20	61317689	61317690	62686337	62686338	8453	hg38	N/A	enh63015	fant59497	Enhatls113098	enhancer	E3040	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13994	0.66582		SLCO4A1	chr20	62642502	62672293	13805	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4167
enhrx-89514	chr2	27959390	27959391	27736523	27736524	8454	hg38	N/A	enh18376	N/A	Enhatls95869	enhancer	E3041	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037764	0.66582		MRPL33	chr2	27771716	27779734	34027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1440
enhrx-57408	chr15	70767332	70767333	70474993	70474994	8455	hg38	N/A	enh16290	N/A	Enhatls61772	enhancer	E3042	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03294	0.66582		UACA	chr15	70654553	70763558	179436	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-109534	chr22	30210198	30210199	29814209	29814210	8456	hg38	N/A	N/A	N/A	Enhatls117211	enhancer	E3043	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0061268	0.66673		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1365
enhrx-15329	chr1	212659698	212659699	212486356	212486357	8457	hg38	N/A	enh12641	fant4719	Enhatls16858	enhancer	E3044	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039331	0.66673		NENF	chr1	212432919	212446379	39334	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15328
enhrx-111474	chr22	46888003	46888004	46492106	46492107	8458	hg38	N/A	enh20265	N/A	Enhatls119297	enhancer	E3045	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074441	0.66673		CELSR1	chr22	46360833	46537620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3305
enhrx-75928	chr17	80730034	80730035	82772158	82772159	8459	hg38	N/A	N/A	N/A	Enhatls81473	enhancer	E3046	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0077726	0.66673		TBCD	chr17	82752041	82945914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9197
enhrx-130445	chr5	1555627	1555628	1555512	1555513	8460	hg38	N/A	enh8368	fant17814	Enhatls139444	enhancer	E3047	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053929	0.66673		LPCAT1	chr5	1461426	1523960	31189	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	236
enhrx-172219	chrX	46069447	46069448	46210012	46210013	8461	hg38	N/A	enh42606	N/A	Enhatls184266	enhancer	E3048	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065375	0.66673		KRBOX4	chrX	46447291	46497422	234732	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1936
enhrx-8099	chr1	95459644	95459645	94994088	94994089	8462	hg38	N/A	enh26979	N/A	Enhatls8775	enhancer	E3049	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035074	0.66673		ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8098
enhrx-145453	chr6	136887420	136887421	136566282	136566283	8463	hg38	N/A	enh97932	N/A	Enhatls155454	enhancer	E3050	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17193	0.66673		MAP3K5	chr6	136557045	136793097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7041
enhrx-89288	chr2	26853976	26853977	26631108	26631109	8464	hg38	N/A	enh18367	N/A	Enhatls95647	enhancer	E3051	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048823	0.66673		CIB4	chr2	26581204	26641366	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1214
enhrx-124893	chr4	55976343	55976344	55110176	55110177	8465	hg38	N/A	N/A	N/A	Enhatls133632	enhancer	E3052	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09739	0.66709		KDR	chr4	55078480	55125595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2437
enhrx-106298	chr21	17011684	17011685	15639365	15639366	8466	hg38	N/A	enh19833	N/A	Enhatls113652	enhancer	E3053	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014036	0.66709		USP25	chr21	15729981	15880064	88546	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-38664	chr12	53295390	53295391	52901606	52901607	8467	hg38	N/A	enh14734	N/A	Enhatls41831	enhancer	E3054	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27604	0.66709		KRT8	chr12	52897186	52949882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3974
enhrx-141135	chr6	40364615	40364616	40396876	40396877	8468	hg38	N/A	enh63537	N/A	Enhatls150877	enhancer	E3055	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049241	0.66727		LRFN2	chr6	40391590	40587364	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2723
enhrx-161041	chr8	110605694	110605695	109593465	109593466	8469	hg38	N/A	enh41378	N/A	Enhatls171995	enhancer	E3056	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041379	0.66727		SYBU	chr8	109573977	109691791	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4832
enhrx-89044	chr2	24794937	24794938	24572068	24572069	8470	hg38	N/A	N/A	N/A	Enhatls95391	enhancer	E3057	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072026	0.66727		NCOA1	chr2	24491253	24770702	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	970
enhrx-80168	chr19	5046697	5046698	5046686	5046687	8471	hg38	N/A	enh4976	N/A	Enhatls86005	enhancer	E3058	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16514	0.6673		KDM4B	chr19	4969112	5153598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1138
enhrx-102934	chr20	24015660	24015661	24035023	24035024	8472	hg38	N/A	enh82253	N/A	Enhatls110058	enhancer	E3059	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065635	0.6673		GGTLC1	chr20	23985049	23988779	44786	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1362
enhrx-41444	chr12	101853806	101853807	101460028	101460029	8473	hg38	N/A	enh62300	N/A	Enhatls44784	enhancer	E3060	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14585	0.66793		SPIC	chr12	101475335	101486997	13199	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6754
enhrx-168058	chr9	127148591	127148592	124386312	124386313	8474	hg38	N/A	enh10985	N/A	Enhatls179878	enhancer	E3061	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051405	0.66798		PSMB7	chr9	124353464	124415444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5325
enhrx-148547	chr7	23799866	23799867	23760247	23760248	8475	hg38	N/A	enh89088	N/A	Enhatls158751	enhancer	E3062	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052409	0.66798		STK31	chr7	23710202	23832513	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-57450	chr15	71406800	71406801	71114461	71114462	8476	hg38	N/A	N/A	fant48773	Enhatls61813	enhancer	E3063	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016703	0.6693		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4152
enhrx-38860	chr12	54239940	54239941	53846156	53846157	8477	hg38	N/A	enh14744	N/A	Enhatls42043	enhancer	E3064	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06599	0.66951		HOXC13	chr12	53938830	53946544	90620	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-50256	chr14	61083524	61083525	60616806	60616807	8478	hg38	N/A	enh92542	N/A	Enhatls54214	enhancer	E3065	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0027983	0.67042		SIX1	chr14	60643420	60658259	22964	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2213
enhrx-17343	chr1	245421780	245421781	245258478	245258479	8479	hg38	N/A	enh87711	N/A	Enhatls18967	enhancer	E3066	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03862	0.67042		KIF26B	chr1	245154984	245709432	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17342
enhrx-167902	chr9	124953024	124953025	122190745	122190746	8480	hg38	N/A	enh63940	N/A	Enhatls179716	enhancer	E3067	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060783	0.67042		MORN5	chr9	122159907	122200088	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5169
enhrx-152056	chr7	97983967	97983968	98354655	98354656	8481	hg38	N/A	enh24355	N/A	Enhatls162526	enhancer	E3068	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03973	0.67073		BAIAP2L1	chr7	98291649	98401090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4868
enhrx-163961	chr9	33329268	33329269	33329270	33329271	8482	hg38	N/A	enh109202	fant32149	Enhatls175074	enhancer	E3069	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13617	0.67091		NFX1	chr9	33290515	33371157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1228
enhrx-37658	chr12	45966179	45966180	45572396	45572397	8483	hg38	N/A	enh62259	N/A	Enhatls40776	enhancer	E3070	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.034757	0.67136		ANO6	chr12	45216019	45440404	126979	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2968
enhrx-49673	chr14	51655672	51655673	51188954	51188955	8484	hg38	N/A	enh80826	N/A	Enhatls53593	enhancer	E3071	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068197	0.67136		TMX1	chr14	51240246	51257655	48010	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1630
enhrx-38843	chr12	53987659	53987660	53593875	53593876	8485	hg38	N/A	enh2370	N/A	Enhatls42025	enhancer	E3072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11528	0.67136		ATF7-NPFF	chr12	53506690	53625979	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4153
enhrx-38843	chr12	53987659	53987660	53593875	53593876	8486	hg38	N/A	enh2370	N/A	Enhatls42025	enhancer	E3072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11528	0.67136		ATF7	chr12	53507855	53626410	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4153
enhrx-167627	chr9	118706729	118706730	115944450	115944451	8487	hg38	N/A	enh25942	fant33454	Enhatls179404	enhancer	E3073	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0044069	0.67136		PAPPA	chr9	116153790	116402321	208899	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4894
enhrx-956	chr1	8180828	8180829	8120768	8120769	8488	hg38	N/A	enh11462	N/A	Enhatls1013	enhancer	E3074	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13879	0.67136		ERRFI1	chr1	8004403	8026309	87152	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-71323	chr17	40305826	40305827	42153808	42153809	8489	hg38	N/A	N/A	N/A	Enhatls76528	enhancer	E3075	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055585	0.67198		RAB5C	chr17	42124977	42155044	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4592
enhrx-173913	chrX	74122923	74122924	74903088	74903089	8490	hg38	N/A	enh110519	N/A	Enhatls186093	enhancer	E3076	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026075	0.67199		NEXMIF	chrX	74732855	74925472	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3630
enhrx-92442	chr2	86182190	86182191	85955067	85955068	8491	hg38	N/A	enh44825	N/A	Enhatls99043	enhancer	E3077	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00092513	0.67244		ST3GAL5	chr2	85837119	85905199	42264	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4368
enhrx-9422	chr1	117008774	117008775	116466152	116466153	8492	hg38	N/A	enh585	N/A	Enhatls10174	enhancer	E3078	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11428	0.67244		CD58	chr1	116514533	116571039	40306	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9421
enhrx-894	chr1	6970132	6970133	6910072	6910073	8493	hg38	N/A	N/A	N/A	Enhatls949	enhancer	E3079	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24056	0.67244		CAMTA1	chr1	6785453	7769706	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	893
enhrx-84423	chr19	39174433	39174434	38683793	38683794	8494	hg38	N/A	enh5125	N/A	Enhatls90486	enhancer	E3080	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0085417	0.67267		ACTN4	chr19	38647648	38731589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5393
enhrx-161651	chr8	129165480	129165481	128153234	128153235	8495	hg38	N/A	enh10538	N/A	Enhatls172665	enhancer	E3081	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029304	0.67267		MYC	chr8	127735433	127742951	408599	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5442
enhrx-18008	chr10	8068887	8068888	8026924	8026925	8496	hg38	N/A	N/A	N/A	Enhatls19672	enhancer	E3082	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13537	0.67267		TAF3	chr10	7818504	8016631	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	443
enhrx-168810	chr9	132448080	132448081	129685801	129685802	8497	hg38	N/A	enh42311	N/A	Enhatls180694	enhancer	E3083	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058	0.67267		PRRX2	chr9	129665646	129722674	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6077
enhrx-109154	chr22	25506348	25506349	25110381	25110382	8498	hg38	N/A	enh48588	N/A	Enhatls116806	enhancer	E3084	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050109	0.67267		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	985
enhrx-147075	chr6	169930258	169930259	169530162	169530163	8499	hg38	N/A	enh46285	N/A	Enhatls157201	enhancer	E3085	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.007578	0.67267		WDR27	chr6	169457211	169702054	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8663
enhrx-17936	chr10	7275939	7275940	7233977	7233978	8500	hg38	N/A	enh12951	N/A	Enhatls19601	enhancer	E3086	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06736	0.67267		SFMBT2	chr10	7158623	7411488	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	371
enhrx-42835	chr12	116758075	116758076	116320270	116320271	8501	hg38	N/A	enh15024	N/A	Enhatls46255	enhancer	E3087	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13849	0.67343		MED13L	chr12	115958575	116277693	34868	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-80058	chr19	4388922	4388923	4388925	4388926	8502	hg38	N/A	enh17871	N/A	Enhatls85886	enhancer	E3088	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013943	0.67343		SH3GL1	chr19	4360369	4400547	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1028
enhrx-111271	chr22	44757131	44757132	44361251	44361252	8503	hg38	N/A	N/A	N/A	Enhatls119061	enhancer	E3089	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052638	0.67399		SHISAL1	chr22	44243664	44312951	47425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3102
enhrx-139006	chr6	15027321	15027322	15027090	15027091	8504	hg38	N/A	enh23060	N/A	Enhatls148610	enhancer	E3090	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052725	0.67412		JARID2	chr6	15246068	15522042	216965	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-136807	chr5	150801678	150801679	151422117	151422118	8505	hg38	N/A	N/A	N/A	Enhatls146202	enhancer	E3091	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021497	0.67412		SLC36A1	chr5	151437045	151492379	13062	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6598
enhrx-103162	chr20	30294785	30294786	31706982	31706983	8506	hg38	N/A	enh19573	N/A	Enhatls110296	enhancer	E3092	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19057	0.67412		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-103162	chr20	30299389	30299390	31711586	31711587	8507	hg38	N/A	enh19573	N/A	Enhatls110296	enhancer	E3093	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057711	0.67412		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-105210	chr20	52468849	52468850	53852310	53852311	8508	hg38	N/A	enh19761	N/A	Enhatls112526	enhancer	E3094	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067612	0.67412		BCAS1	chr20	53936776	54070594	81241	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3638
enhrx-121002	chr3	178781887	178781888	179064099	179064100	8509	hg38	N/A	enh82889	N/A	Enhatls129487	enhancer	E3095	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014186	0.67412		ZMAT3	chr3	178960120	179072215	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9131
enhrx-51703	chr14	81811337	81811338	81344993	81344994	8510	hg38	N/A	N/A	N/A	Enhatls55759	enhancer	E3096	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055366	0.67463		STON2	chr14	81260651	81436465	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3660
enhrx-163080	chr9	5894068	5894069	5894068	5894069	8511	hg38	N/A	N/A	N/A	Enhatls174153	enhancer	E3097	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035491	0.67487		MLANA	chr9	5890888	5910606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	347
enhrx-100605	chr2	233160917	233160918	232296207	232296208	8512	hg38	N/A	enh48432	N/A	Enhatls107631	enhancer	E3098	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12064	0.67487		DIS3L2	chr2	231961244	232344350	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12531
enhrx-139453	chr6	26170585	26170586	26170357	26170358	8513	hg38	N/A	N/A	N/A	Enhatls149091	enhancer	E3099	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041073	0.67487		H2BC5	chr6	26158121	26171349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1041
enhrx-78085	chr18	48496808	48496809	50970438	50970439	8514	hg38	N/A	N/A	N/A	Enhatls83771	enhancer	E3100	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24943	0.67577		ELAC1	chr18	50967990	50988121	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2103
enhrx-16590	chr1	232824377	232824378	232688631	232688632	8515	hg38	N/A	enh50242	N/A	Enhatls18181	enhancer	E3101	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11819	0.67583		SIPA1L2	chr1	232397964	232630516	42824	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16589
enhrx-102751	chr20	20185977	20185978	20205333	20205334	8516	hg38	N/A	enh45104	N/A	Enhatls109871	enhancer	E3102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061451	0.67583		CFAP61	chr20	20052513	20360698	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1179
enhrx-65999	chr16	82429027	82429028	82395422	82395423	8517	hg38	N/A	N/A	N/A	Enhatls70846	enhancer	E3103	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10805	0.67583		CDH13	chr16	82626964	83800640	189183	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6294
enhrx-131622	chr5	38783284	38783285	38783182	38783183	8518	hg38	N/A	enh22165	N/A	Enhatls140691	enhancer	E3104	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020047	0.67583		OSMR	chr5	38845857	38935641	60023	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1413
enhrx-46635	chr13	74352920	74352921	73778783	73778784	8519	hg38	N/A	enh92475	N/A	Enhatls50353	enhancer	E3105	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071433	0.67583		KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2257
enhrx-28182	chr11	45870257	45870258	45848706	45848707	8520	hg38	N/A	enh64465	N/A	Enhatls30675	enhancer	E3106	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.075878	0.67583		CRY2	chr11	45847117	45883248	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2851
enhrx-46467	chr13	59932222	59932223	59358088	59358089	8521	hg38	N/A	enh64729	N/A	Enhatls50171	enhancer	E3107	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053651	0.67583		DIAPH3	chr13	59665582	60163928	303222	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2089
enhrx-95649	chr2	149981779	149981780	149125265	149125266	8522	hg38	N/A	enh88525	fant8906	Enhatls102401	enhancer	E3108	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095703	0.67583		LYPD6B	chr2	149038698	149215262	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7575
enhrx-83335	chr19	24183692	24183693	24000890	24000891	8523	hg38	N/A	enh18001	N/A	Enhatls89378	enhancer	E3109	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12376	0.67713		ZNF254	chr19	24033404	24129968	23792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4305
enhrx-103496	chr20	32403651	32403652	33815845	33815846	8524	hg38	N/A	enh60932	N/A	N/A	enhancer	E3110	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11202	0.67716		CHMP4B	chr20	33811347	33854366	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1924
enhrx-63649	chr16	48641077	48641078	48607166	48607167	8525	hg38	N/A	enh16648	N/A	Enhatls68328	enhancer	E3111	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085448	0.67716		N4BP1	chr16	48538725	48610180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3944
enhrx-151510	chr7	89696693	89696694	90067379	90067380	8526	hg38	N/A	N/A	N/A	Enhatls161974	enhancer	E3112	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15148	0.67866		STEAP1	chr7	90154468	90164827	40105	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4322
enhrx-43453	chr12	122952698	122952699	122468151	122468152	8527	hg38	N/A	enh15070	N/A	Enhatls46913	enhancer	E3113	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086107	0.67866		ZCCHC8	chr12	122471599	122500932	3445	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8763
enhrx-137186	chr5	158960405	158960406	159533397	159533398	8528	hg38	N/A	enh57924	N/A	Enhatls146605	enhancer	E3114	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013478	0.67944		IL12B	chr5	159314779	159330862	198889	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6977
enhrx-73344	chr17	59278679	59278680	61201318	61201319	8529	hg38	N/A	enh32253	N/A	Enhatls78727	enhancer	E3115	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12413	0.67944		BCAS3	chr17	60677452	61392838	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6613
enhrx-49493	chr14	50237242	50237243	49770524	49770525	8530	hg38	N/A	N/A	N/A	Enhatls53393	enhancer	E3116	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022217	0.67944		KLHDC2	chr14	49768152	49786385	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1450
enhrx-117137	chr3	104229475	104229476	104510631	104510632	8531	hg38	N/A	enh7407	N/A	Enhatls125355	enhancer	E3117	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10636	0.67944		ALCAM	chr3	105366908	105576900	850298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5266
enhrx-140957	chr6	38101955	38101956	38134179	38134180	8532	hg38	N/A	enh38973	N/A	Enhatls150693	enhancer	E3118	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037399	0.67944		ZFAND3	chr6	37819726	38154624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2545
enhrx-56742	chr15	63671856	63671857	63379657	63379658	8533	hg38	N/A	N/A	N/A	Enhatls61048	enhancer	E3119	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0078767	0.67944		CA12	chr15	63321377	63381846	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3444
enhrx-21514	chr10	80887012	80887013	79127255	79127256	8534	hg38	N/A	enh1379	N/A	Enhatls23677	enhancer	E3120	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13074	0.67944		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3949
enhrx-156422	chr8	5997631	5997632	6140109	6140110	8535	hg38	N/A	enh78360	N/A	Enhatls167091	enhancer	E3121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061739	0.67969		MCPH1	chr8	6406591	6648508	264419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	213
enhrx-19335	chr10	35008477	35008478	34719549	34719550	8536	hg38	N/A	enh13154	N/A	Enhatls21132	enhancer	E3122	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00099716	0.67969		PARD3	chr10	34109559	34815325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1770
enhrx-114650	chr3	48398173	48398174	48356683	48356684	8537	hg38	N/A	enh97263	N/A	Enhatls122685	enhancer	E3123	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042078	0.67969		FBXW12	chr3	48372218	48394725	13554	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2779
enhrx-148643	chr7	26753767	26753768	26714148	26714149	8538	hg38	N/A	N/A	N/A	Enhatls158861	enhancer	E3124	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0006205	0.67969		SKAP2	chr7	26667067	26995239	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1455
enhrx-112897	chr3	16884362	16884363	16842855	16842856	8539	hg38	N/A	enh45342	fant11397	Enhatls120804	enhancer	E3125	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058062	0.6804		PLCL2	chr3	16884954	17090604	42099	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1026
enhrx-138732	chr6	7562075	7562076	7561842	7561843	8540	hg38	"hs2651,hs2191"	enh84080	N/A	Enhatls148316	enhancer	E3126	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05198	0.6804		DSP	chr6	7541337	7586714	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	320
enhrx-65570	chr16	73030700	73030701	72996801	72996802	8541	hg38	N/A	enh16769	N/A	Enhatls70361	enhancer	E3127	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0095503	0.68065		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5865
enhrx-159077	chr8	60932973	60932974	60020414	60020415	8542	hg38	N/A	N/A	N/A	Enhatls169927	enhancer	E3128	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011432	0.68067		CA8	chr8	60185411	60281400	138750	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2868
enhrx-144307	chr6	111598171	111598172	111276968	111276969	8543	hg38	N/A	enh9316	N/A	Enhatls154224	enhancer	E3129	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029402	0.68067		MFSD4B	chr6	111259326	111280005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5895
enhrx-119213	chr3	134079628	134079629	134360786	134360787	8544	hg38	N/A	N/A	N/A	Enhatls127570	enhancer	E3130	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10256	0.68067		AMOTL2	chr3	134355346	134375479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7342
enhrx-157849	chr8	29418761	29418762	29561244	29561245	8545	hg38	N/A	enh10214	N/A	Enhatls168631	enhancer	E3131	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022443	0.68067		DUSP4	chr8	29333063	29350684	205063	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-105210	chr20	52422566	52422567	53806027	53806028	8546	hg38	N/A	enh19760	N/A	Enhatls112526	enhancer	E3132	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045507	0.68067		BCAS1	chr20	53936776	54070594	124561	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3638
enhrx-100000	chr2	220984982	220984983	220120261	220120262	8547	hg38	N/A	N/A	N/A	Enhatls106992	enhancer	E3133	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.003442	0.68067		SLC4A3	chr2	219627393	219641980	465375	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11926
enhrx-19067	chr10	28552272	28552273	28263343	28263344	8548	hg38	N/A	enh58262	N/A	Enhatls20832	enhancer	E3134	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072426	0.68067		MPP7	chr10	28050992	28334486	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1502
enhrx-24689	chr10	125844567	125844568	124085051	124085052	8549	hg38	N/A	N/A	N/A	Enhatls27061	enhancer	E3135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0029978	0.68096		CHST15	chr10	124007667	124093598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7124
enhrx-161139	chr8	116519363	116519364	115507136	115507137	8550	hg38	N/A	N/A	N/A	Enhatls172096	enhancer	E3136	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11085	0.68096		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4930
enhrx-125557	chr4	71668885	71668886	70803168	70803169	8551	hg38	N/A	N/A	N/A	Enhatls134321	enhancer	E3137	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34827	0.68096		RUFY3	chr4	70704203	70808619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3101
enhrx-82252	chr19	15699305	15699306	15588494	15588495	8552	hg38	N/A	N/A	N/A	Enhatls88194	enhancer	E3138	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085118	0.68096		CYP4F8	chr19	15615217	15630639	23391	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3222
enhrx-111990	chr3	3678653	3678654	3636969	3636970	8553	hg38	N/A	enh20285	N/A	Enhatls119831	enhancer	E3139	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17825	0.68134		LRRN1	chr3	3799430	3849834	160340	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	119
enhrx-137164	chr5	158602769	158602770	159175761	159175762	8554	hg38	N/A	enh22759	N/A	Enhatls146575	enhancer	E3140	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064148	0.68134		RNF145	chr5	159157408	159210053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6955
enhrx-25058	chr10	133862004	133862005	132048500	132048501	8555	hg38	N/A	enh96171	fant37501	Enhatls27399	enhancer	E3141	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061234	0.68134		JAKMIP3	chr10	132036335	132184858	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7493
enhrx-153531	chr7	116492053	116492054	116851999	116852000	8556	hg38	N/A	N/A	N/A	Enhatls164068	enhancer	E3142	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06703	0.68134		CAPZA2	chr7	116811069	116922049	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6343
enhrx-33995	chr11	121525719	121525720	121655010	121655011	8557	hg38	N/A	enh29202	N/A	Enhatls36887	enhancer	E3143	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066135	0.68134		SORL1	chr11	121452313	121633763	17247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8664
enhrx-23862	chr10	114476931	114476932	112717172	112717173	8558	hg38	N/A	enh1514	N/A	Enhatls26194	enhancer	E3144	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14416	0.68134		VTI1A	chr10	112447033	112818744	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6297
enhrx-95953	chr2	155339633	155339634	154483121	154483122	8559	hg38	N/A	enh53358	N/A	Enhatls102718	enhancer	E3145	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030358	0.68134		GALNT13	chr2	153871921	154453979	28455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7879
enhrx-157083	chr8	19745496	19745497	19887985	19887986	8560	hg38	N/A	enh78396	N/A	Enhatls167810	enhancer	E3146	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.077837	0.68134		LPL	chr8	19901716	19967259	11233	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	874
enhrx-44869	chr13	26194228	26194229	25620090	25620091	8561	hg38	N/A	enh96392	N/A	Enhatls48406	enhancer	E3147	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11755	0.68239		ATP8A2	chr13	25371973	26025851	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	491
enhrx-165916	chr9	93011598	93011599	90249316	90249317	8562	hg38	N/A	N/A	N/A	Enhatls177558	enhancer	E3148	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19187	0.68325		DIRAS2	chr9	90609831	90642862	342590	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3183
enhrx-63062	chr16	30689782	30689783	30678461	30678462	8563	hg38	N/A	enh16629	N/A	Enhatls67741	enhancer	E3149	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0092986	0.68325		FBRS	chr16	30658430	30670810	7595	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3357
enhrx-147561	chr7	4739878	4739879	4700247	4700248	8564	hg38	N/A	enh9572	N/A	Enhatls157695	enhancer	E3150	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096075	0.68325		FOXK1	chr7	4682294	4771442	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	373
enhrx-166230	chr9	97506106	97506107	94743824	94743825	8565	hg38	N/A	enh42098	N/A	Enhatls177911	enhancer	E3151	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0050739	0.68325		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3497
enhrx-155984	chr7	155324736	155324737	155532041	155532042	8566	hg38	N/A	N/A	N/A	Enhatls166651	enhancer	E3152	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15146	0.68325		CNPY1	chr7	155474205	155555450	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8796
enhrx-48805	chr14	29098732	29098733	28629526	28629527	8567	hg38	N/A	enh96483	N/A	Enhatls52693	enhancer	E3153	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041292	0.68325		FOXG1	chr14	28764328	28770277	132740	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	762
enhrx-159087	chr8	61251113	61251114	60338554	60338555	8568	hg38	N/A	N/A	N/A	Enhatls169938	enhancer	E3154	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045798	0.68325		CA8	chr8	60185411	60281400	51097	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2878
enhrx-8315	chr1	100820712	100820713	100355156	100355157	8569	hg38	N/A	enh524	fant2548	Enhatls9001	enhancer	E3155	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077186	0.68333		CDC14A	chr1	100345021	100520277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8314
enhrx-106294	chr21	16084602	16084603	14712281	14712282	8570	hg38	N/A	enh97168	N/A	Enhatls113648	enhancer	E3156	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11238	0.68333		SAMSN1	chr21	14485227	14658821	51364	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	177
enhrx-127357	chr4	108135908	108135909	107214751	107214752	8571	hg38	N/A	enh115857	N/A	Enhatls136210	enhancer	E3157	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027506	0.68333		DKK2	chr4	106921801	107283806	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4901
enhrx-109040	chr22	24608312	24608313	24212344	24212345	8572	hg38	N/A	enh20089	N/A	Enhatls116676	enhancer	E3158	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01478	0.68334		GGT5	chr22	24219653	24245082	2570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	871
enhrx-133682	chr5	82683066	82683067	83387247	83387248	8573	hg38	N/A	enh83783	fant19120	Enhatls142813	enhancer	E3159	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13351	0.68334		XRCC4	chr5	83077497	83353787	33253	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3473
enhrx-157421	chr8	23501334	23501335	23643821	23643822	8574	hg38	N/A	N/A	N/A	Enhatls168181	enhancer	E3160	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16606	0.68334		NKX3-1	chr8	23678696	23682938	10	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1212
enhrx-111910	chr3	1292208	1292209	1250524	1250525	8575	hg38	N/A	N/A	N/A	Enhatls119751	enhancer	E3161	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.45835	0.68334		CNTN6	chr3	1092660	1404217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	39
enhrx-17771	chr10	5122243	5122244	5080051	5080052	8576	hg38	N/A	N/A	N/A	Enhatls19416	enhancer	E3162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072456	0.68334		AKR1C3	chr10	5048788	5107686	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	206
enhrx-49223	chr14	38314902	38314903	37845697	37845698	8577	hg38	N/A	N/A	N/A	Enhatls53123	enhancer	E3163	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097389	0.68366		TTC6	chr14	37595628	37842717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-157849	chr8	29667380	29667381	29809864	29809865	8578	hg38	N/A	enh40854	N/A	Enhatls168638	enhancer	E3164	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061969	0.68451		SARAF	chr8	30063002	30083208	248009	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-134982	chr5	125217984	125217985	125882291	125882292	8579	hg38	N/A	enh59533	N/A	Enhatls144195	enhancer	E3165	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066995	0.68484		GRAMD2B	chr5	126360131	126494371	474538	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4773
enhrx-161932	chr8	135756216	135756217	134743973	134743974	8580	hg38	N/A	enh25367	N/A	Enhatls172977	enhancer	E3166	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063834	0.68554		ZFAT	chr8	134477787	134713031	24552	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5723
enhrx-92168	chr2	76484005	76484006	76256879	76256880	8581	hg38	N/A	enh96907	N/A	Enhatls98753	enhancer	E3167	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092602	0.68554		LRRTM4	chr2	76747684	77593196	488756	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4094
enhrx-126839	chr4	95591634	95591635	94670483	94670484	8582	hg38	N/A	enh65870	N/A	Enhatls135674	enhancer	E3168	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15633	0.68554		PDLIM5	chr4	94451856	94668227	2082	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4383
enhrx-123095	chr4	5130384	5130385	5128657	5128658	8583	hg38	N/A	enh110113	N/A	Enhatls131720	enhancer	E3169	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027024	0.68554		STK32B	chr4	5051479	5500994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	639
enhrx-33005	chr11	110634425	110634426	110763702	110763703	8584	hg38	N/A	enh74908	N/A	Enhatls35812	enhancer	E3170	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079409	0.68554		ARHGAP20	chr11	110577041	110713189	43354	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7674
enhrx-111519	chr22	47498756	47498757	47102860	47102861	8585	hg38	N/A	enh20273	fant61706	Enhatls119345	enhancer	E3171	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033829	0.68612		TBC1D22A	chr22	46762616	47175699	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3350
enhrx-94285	chr2	113836939	113836940	113079362	113079363	8586	hg38	N/A	enh44861	N/A	Enhatls100962	enhancer	E3172	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066089	0.68612		IL1F10	chr2	113067969	113075843	2987	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6211
enhrx-88639	chr2	14428329	14428330	14288205	14288206	8587	hg38	N/A	enh62755	N/A	Enhatls94967	enhancer	E3173	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096795	0.68616		LRATD1	chr2	14632699	14640041	341145	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	565
enhrx-133601	chr5	80467807	80467808	81171988	81171989	8588	hg38	N/A	enh8530	N/A	Enhatls142722	enhancer	E3174	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13029	0.68616		RASGRF2	chr5	80960362	81230162	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3392
enhrx-78320	chr18	55365969	55365970	57698737	57698738	8589	hg38	N/A	N/A	N/A	Enhatls84021	enhancer	E3175	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17873	0.68713		ATP8B1	chr18	57646425	57803315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2338
enhrx-159703	chr8	75547892	75547893	74635657	74635658	8590	hg38	N/A	enh98125	N/A	Enhatls170589	enhancer	E3176	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.043145	0.68713		GDAP1	chr8	74320612	74494697	138774	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3494
enhrx-107023	chr21	37489672	37489673	36117374	36117375	8591	hg38	N/A	enh19937	N/A	Enhatls114439	enhancer	E3177	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038394	0.68713		CBR3	chr21	36135078	36146562	16864	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	906
enhrx-107023	chr21	37445930	37445931	36073632	36073633	8592	hg38	N/A	enh19935	N/A	Enhatls114437	enhancer	E3178	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17783	0.68856		SETD4	chr21	36034540	36079389	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	906
enhrx-8696	chr1	109599775	109599776	109057153	109057154	8593	hg38	N/A	N/A	N/A	Enhatls9384	enhancer	E3179	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013669	0.68856		TAF13	chr1	109062495	109076012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8695
enhrx-78797	chr18	71562983	71562984	73895748	73895749	8594	hg38	N/A	enh4907	N/A	Enhatls84539	enhancer	E3180	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0096718	0.68856		FBXO15	chr18	74073367	74147843	177534	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2815
enhrx-105096	chr20	48845939	48845940	50229402	50229403	8595	hg38	N/A	enh19713	N/A	Enhatls112385	enhancer	E3181	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12499	0.68967		CEBPB	chr20	50190829	50192668	34292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3524
enhrx-148637	chr7	26593369	26593370	26553750	26553751	8596	hg38	N/A	N/A	N/A	Enhatls158853	enhancer	E3182	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057168	0.69062		SKAP2	chr7	26667067	26995239	112782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1449
enhrx-113155	chr3	27366430	27366431	27324939	27324940	8597	hg38	N/A	enh35278	N/A	Enhatls121080	enhancer	E3183	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032356	0.69084		NEK10	chr3	27106483	27369460	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1284
enhrx-154222	chr7	129493739	129493740	129853899	129853900	8598	hg38	N/A	enh10030	fant27684	Enhatls164796	enhancer	E3184	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10045	0.69084		UBE2H	chr7	129830731	129952960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7034
enhrx-116458	chr3	71244818	71244819	71195667	71195668	8599	hg38	N/A	enh7310	N/A	Enhatls124627	enhancer	E3185	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0023619	0.69084		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4587
enhrx-161644	chr8	128794947	128794948	127782701	127782702	8600	hg38	N/A	enh85259	N/A	Enhatls172651	enhancer	E3186	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0029252	0.69084		MYC	chr8	127735433	127742951	36989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5435
enhrx-149035	chr7	33952398	33952399	33912786	33912787	8601	hg38	N/A	N/A	N/A	Enhatls159281	enhancer	E3187	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16455	0.69084		BMPER	chr7	33904910	34156427	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1847
enhrx-52616	chr14	100498566	100498567	100032229	100032230	8602	hg38	N/A	enh15935	N/A	Enhatls56746	enhancer	E3188	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083021	0.69088		EVL	chr14	99971448	100144236	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4573
enhrx-90398	chr2	43137964	43137965	42910824	42910825	8603	hg38	N/A	enh18488	N/A	Enhatls96840	enhancer	E3189	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085985	0.69088		HAAO	chr2	42767088	42792583	102140	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2324
enhrx-42835	chr12	116732597	116732598	116294792	116294793	8604	hg38	N/A	enh51417	N/A	Enhatls46255	enhancer	E3190	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074258	0.69143		MED13L	chr12	115958575	116277693	14048	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-167586	chr9	117614701	117614702	114852421	114852422	8605	hg38	N/A	enh42218	N/A	Enhatls179354	enhancer	E3191	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16498	0.69148		TNFSF8	chr9	114893342	114930595	34168	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4853
enhrx-146930	chr6	167514472	167514473	167100984	167100985	8606	hg38	N/A	enh56103	N/A	Enhatls157058	enhancer	E3192	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029894	0.69148		CCR6	chr6	167111806	167139141	5825	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8518
enhrx-82354	chr19	16335282	16335283	16224471	16224472	8607	hg38	N/A	N/A	N/A	Enhatls88306	enhancer	E3193	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0552	0.69205		AP1M1	chr19	16197853	16245906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3324
enhrx-101772	chr20	2286757	2286758	2306111	2306112	8608	hg38	N/A	enh19443	N/A	Enhatls108834	enhancer	E3194	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12133	0.69205		TGM3	chr20	2296000	2341079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	200
enhrx-103806	chr20	34364584	34364585	35776662	35776663	8609	hg38	N/A	enh109962	N/A	Enhatls111012	enhancer	E3195	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02328	0.69206		PHF20	chr20	35772014	35950370	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2234
enhrx-107224	chr21	40008459	40008460	38636535	38636536	8610	hg38	N/A	enh97199	N/A	Enhatls114655	enhancer	E3196	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02164	0.69241		ERG	chr21	38380026	38661780	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1107
enhrx-72932	chr17	55844105	55844106	57766744	57766745	8611	hg38	N/A	enh81236	N/A	Enhatls78295	enhancer	E3197	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083218	0.69241		CCDC182	chr17	57744494	57745299	19386	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6201
enhrx-91965	chr2	74135118	74135119	73907991	73907992	8612	hg38	N/A	N/A	N/A	Enhatls98538	enhancer	E3198	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13292	0.69241		ACTG2	chr2	73892966	73919865	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-136058	chr5	140420691	140420692	141041106	141041107	8613	hg38	"hs2610,hs3017"	enh90329	N/A	Enhatls145346	enhancer	E3199	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15843	0.69241		PCDHB1	chr5	141051373	141059346	9355	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5849
enhrx-24970	chr10	131320846	131320847	129522582	129522583	8614	hg38	N/A	enh95424	N/A	Enhatls27331	enhancer	E3200	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0074571	0.69241		MGMT	chr10	129467189	129770983	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7405
enhrx-114620	chr3	48041883	48041884	48000393	48000394	8615	hg38	N/A	enh48689	N/A	Enhatls122655	enhancer	E3201	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098875	0.69242		MAP4	chr3	47850689	48089272	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2749
enhrx-3043	chr1	26441234	26441235	26114743	26114744	8616	hg38	N/A	N/A	N/A	Enhatls3381	enhancer	E3202	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061085	0.69242		PDIK1L	chr1	26111164	26125555	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3042
enhrx-20474	chr10	64873941	64873942	63114181	63114182	8617	hg38	N/A	enh13260	N/A	Enhatls22560	enhancer	E3203	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034927	0.69242		NRBF2	chr10	63133246	63155031	17329	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2909
enhrx-31687	chr11	78185680	78185681	78474634	78474635	8618	hg38	N/A	enh79940	N/A	Enhatls34434	enhancer	E3204	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13351	0.69315		NARS2	chr11	78435967	78574874	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6356
enhrx-120142	chr3	153023223	153023224	153305434	153305435	8619	hg38	N/A	enh95640	N/A	Enhatls128543	enhancer	E3205	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091484	0.69315		RAP2B	chr3	153162225	153170627	132670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8271
enhrx-32494	chr11	102113045	102113046	102242314	102242315	8620	hg38	N/A	enh14233	N/A	Enhatls35284	enhancer	E3206	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020654	0.69315		YAP1	chr11	102110446	102233424	2951	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7163
enhrx-19091	chr10	29229020	29229021	28940091	28940092	8621	hg38	N/A	enh50370	fant35211	Enhatls20864	enhancer	E3207	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060039	0.69326		BAMBI	chr10	28677520	28682932	256763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-107314	chr21	41224120	41224121	39852193	39852194	8622	hg38	N/A	enh97200	N/A	Enhatls114760	enhancer	E3208	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036903	0.69341		PCP4	chr21	39867437	39929392	12110	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1197
enhrx-58309	chr15	80287207	80287208	79994865	79994866	8623	hg38	N/A	enh16364	N/A	Enhatls62730	enhancer	E3209	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063759	0.69341		BCL2A1	chr15	79960891	79971196	15894	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5011
enhrx-27986	chr11	38387251	38387252	38365701	38365702	8624	hg38	N/A	N/A	N/A	Enhatls30456	enhancer	E3210	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10969	0.69341		IFTAP	chr11	36594368	36659291	1688315	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2655
enhrx-56700	chr15	63228110	63228111	62935911	62935912	8625	hg38	N/A	enh31444	N/A	Enhatls61001	enhancer	E3211	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11131	0.69341		TLN2	chr15	62390549	62844631	81562	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3402
enhrx-148745	chr7	29437199	29437200	29397583	29397584	8626	hg38	N/A	N/A	N/A	Enhatls158966	enhancer	E3212	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087279	0.69341		CHN2	chr7	29194425	29514328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1557
enhrx-171575	chrX	25006348	25006349	24988231	24988232	8627	hg38	N/A	N/A	N/A	Enhatls183605	enhancer	E3213	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030712	0.69341		POLA1	chrX	24693917	24996986	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1292
enhrx-18012	chr10	8163304	8163305	8121341	8121342	8628	hg38	N/A	N/A	N/A	Enhatls19676	enhancer	E3214	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13812	0.69341		GATA3	chr10	8045377	8075198	42675	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	447
enhrx-135466	chr5	133356005	133356006	134020314	134020315	8629	hg38	N/A	enh22583	N/A	Enhatls144715	enhancer	E3215	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016646	0.6939		VDAC1	chr5	133971870	134004975	11143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5257
enhrx-3112	chr1	26739244	26739245	26412753	26412754	8630	hg38	N/A	N/A	fant871	Enhatls3459	enhancer	E3216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11159	0.6939		LIN28A	chr1	26410816	26429728	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3111
enhrx-132682	chr5	67830428	67830429	68534601	68534602	8631	hg38	N/A	enh37935	N/A	Enhatls141794	enhancer	E3217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13753	0.69409		PIK3R1	chr5	68215740	68301821	225118	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2473
enhrx-75292	chr17	77809997	77809998	79836198	79836199	8632	hg38	N/A	N/A	N/A	Enhatls80819	enhancer	E3218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018906	0.69409		CBX4	chr17	79833155	79839440	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8561
enhrx-60889	chr16	4919726	4919727	4869725	4869726	8633	hg38	N/A	N/A	N/A	Enhatls65465	enhancer	E3219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1017	0.69409		UBN1	chr16	4846664	4882401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1184
enhrx-141263	chr6	42085176	42085177	42117438	42117439	8634	hg38	N/A	enh23246	N/A	Enhatls151021	enhancer	E3220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.069716	0.69409		C6orf132	chr6	42101118	42142620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2851
enhrx-121822	chr3	187507948	187507949	187790160	187790161	8635	hg38	N/A	N/A	N/A	Enhatls130371	enhancer	E3221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022033	0.69409		BCL6-AS1	chr3	187743685	187746028	39505	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9951
enhrx-106393	chr21	22229449	22229450	20857131	20857132	8636	hg38	N/A	N/A	N/A	Enhatls113756	enhancer	E3222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044079	0.69446		NCAM2	chr21	20998408	21543329	119622	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	276
enhrx-140963	chr6	38450494	38450495	38482718	38482719	8637	hg38	N/A	enh87387	N/A	Enhatls150700	enhancer	E3223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11353	0.69446		BTBD9	chr6	38168450	38640148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2551
enhrx-956	chr1	8121518	8121519	8061458	8061459	8638	hg38	N/A	enh11460	fant241	Enhatls1013	enhancer	E3224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26079	0.695		ERRFI1	chr1	8004403	8026309	35068	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-3522	chr1	30155883	30155884	29683036	29683037	8639	hg38	N/A	enh42921	N/A	Enhatls3896	enhancer	E3225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22421	0.695		PTPRU	chr1	29236515	29326813	352046	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3521
enhrx-19296	chr10	33328221	33328222	33039293	33039294	8640	hg38	N/A	N/A	N/A	Enhatls21086	enhancer	E3226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0092482	0.695		ITGB1	chr10	32887272	32992463	42594	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1731
enhrx-113297	chr3	32281930	32281931	32240438	32240439	8641	hg38	N/A	N/A	N/A	Enhatls121227	enhancer	E3227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020878	0.695		CMTM8	chr3	32238678	32370321	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1426
enhrx-73196	chr17	57833929	57833930	59756568	59756569	8642	hg38	N/A	enh4505	fant53190	Enhatls78577	enhancer	E3228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051815	0.695		VMP1	chr17	59707516	59842255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6465
enhrx-14955	chr1	207176294	207176295	207002949	207002950	8643	hg38	N/A	enh12599	N/A	Enhatls16459	enhancer	E3229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31065	0.69555		C1orf116	chr1	207018521	207032756	11137	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14954
enhrx-154225	chr7	129617398	129617399	129977558	129977559	8644	hg38	N/A	enh24505	N/A	Enhatls164801	enhancer	E3230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059342	0.69555		UBE2H	chr7	129830731	129952960	17292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7037
enhrx-69405	chr17	25801264	25801265	27474238	27474239	8645	hg38	N/A	enh17063	N/A	Enhatls74506	enhancer	E3231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.028797	0.69555		KSR1	chr17	27456447	27626438	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2674
enhrx-112899	chr3	17036869	17036870	16995377	16995378	8646	hg38	N/A	enh57823	N/A	Enhatls120806	enhancer	E3232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13942	0.69569		PLCL2	chr3	16884954	17090604	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1028
enhrx-113592	chr3	37584566	37584567	37543075	37543076	8647	hg38	N/A	enh63126	N/A	Enhatls121544	enhancer	E3233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051692	0.69649		ITGA9	chr3	37452114	37823507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1721
enhrx-18240	chr10	13750912	13750913	13708912	13708913	8648	hg38	N/A	enh1120	N/A	Enhatls19928	enhancer	E3234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051433	0.69681		FRMD4A	chr10	13643705	14462142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	675
enhrx-21484	chr10	79731248	79731249	77971490	77971491	8649	hg38	N/A	enh28264	fant36241	Enhatls23633	enhancer	E3235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03991	0.69682		POLR3A	chr10	77975148	78029515	3655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3919
enhrx-69962	chr17	30185539	30185540	31858520	31858521	8650	hg38	N/A	N/A	N/A	Enhatls75100	enhancer	E3236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035134	0.69689		COPRS	chr17	31851870	31859244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3231
enhrx-105156	chr20	50142823	50142824	51526284	51526285	8651	hg38	N/A	enh6542	N/A	Enhatls112461	enhancer	E3237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0059609	0.69696		NFATC2	chr20	51386956	51562831	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3584
enhrx-58325	chr15	80455643	80455644	80163301	80163302	8652	hg38	N/A	N/A	N/A	Enhatls62745	enhancer	E3238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043334	0.69743		FAH	chr15	80152489	80186946	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5027
enhrx-89671	chr2	30029482	30029483	29806616	29806617	8653	hg38	N/A	enh81612	N/A	Enhatls96057	enhancer	E3239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0051184	0.69743		ALK	chr2	29192773	29921586	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1597
enhrx-62408	chr16	24709848	24709849	24698527	24698528	8654	hg38	N/A	N/A	N/A	Enhatls67042	enhancer	E3240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022104	0.69743		TNRC6A	chr16	24729650	24827632	30898	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2703
enhrx-28593	chr11	48032787	48032788	48011235	48011236	8655	hg38	N/A	enh1779	N/A	Enhatls31101	enhancer	E3241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12886	0.69743		PTPRJ	chr11	47980424	48170839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3262
enhrx-74969	chr17	74637823	74637824	76641741	76641742	8656	hg38	N/A	N/A	N/A	Enhatls80460	enhancer	E3242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084393	0.69743		ST6GALNAC1	chr17	76624762	76643757	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8238
enhrx-106298	chr21	16816747	16816748	15444428	15444429	8657	hg38	N/A	enh70333	N/A	Enhatls113652	enhancer	E3243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018288	0.69761		USP25	chr21	15729981	15880064	281589	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-169146	chr9	134721118	134721119	131845731	131845732	8658	hg38	N/A	N/A	N/A	Enhatls181062	enhancer	E3244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016183	0.69762		MED27	chr9	131852927	132079867	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6413
enhrx-15881	chr1	224393184	224393185	224205482	224205483	8659	hg38	N/A	enh12716	N/A	Enhatls17435	enhancer	E3245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0088339	0.69798		DEGS1	chr1	224175755	224193441	551	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15880
enhrx-136126	chr5	141093634	141093635	141714067	141714068	8660	hg38	N/A	enh22641	N/A	Enhatls145423	enhancer	E3246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027584	0.69798		ARAP3	chr5	141653400	141682230	28964	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5917
enhrx-89610	chr2	29174995	29174996	28952129	28952130	8661	hg38	N/A	N/A	fant6422	Enhatls95992	enhancer	E3247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055713	0.6986		WDR43	chr2	28894666	28948219	3734	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1536
enhrx-161365	chr8	122439177	122439178	121426937	121426938	8662	hg38	N/A	enh93756	N/A	Enhatls172343	enhancer	E3248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10665	0.6986		HAS2	chr8	121612115	121641440	180841	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-29169	chr11	60657781	60657782	60890309	60890310	8663	hg38	N/A	N/A	N/A	Enhatls31689	enhancer	E3249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05507	0.69891		PRPF19	chr11	60890546	60906585	9	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3838
enhrx-2274	chr1	19712537	19712538	19386043	19386044	8664	hg38	N/A	enh98	N/A	Enhatls2532	enhancer	E3250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07329	0.69892		CAPZB	chr1	19338774	19485539	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2273
enhrx-15604	chr1	219704604	219704605	219531262	219531263	8665	hg38	N/A	enh95975	N/A	Enhatls17145	enhancer	E3251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048621	0.69892		ZC3H11B	chr1	219608011	219613105	72459	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15603
enhrx-109528	chr22	30194880	30194881	29798891	29798892	8666	hg38	N/A	N/A	N/A	Enhatls117205	enhancer	E3252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083689	0.69892		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-105203	chr20	51963014	51963015	53346475	53346476	8667	hg38	N/A	enh88624	N/A	Enhatls112514	enhancer	E3253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13547	0.69892		TSHZ2	chr20	52972357	53495330	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3631
enhrx-132637	chr5	65976435	65976436	66680607	66680608	8668	hg38	N/A	N/A	N/A	Enhatls141742	enhancer	E3254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0062001	0.69892		MAST4	chr5	66596379	67169593	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2428
enhrx-130333	chr5	957174	957175	957059	957060	8669	hg38	N/A	enh22023	fant17746	Enhatls139318	enhancer	E3255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032766	0.69892		TRIP13	chr5	892883	918120	38861	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	124
enhrx-134748	chr5	117662377	117662378	118326682	118326683	8670	hg38	N/A	enh38293	N/A	Enhatls143943	enhancer	E3256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013768	0.69892		DTWD2	chr5	118836073	118988547	507254	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4539
enhrx-42833	chr12	116702561	116702562	116264756	116264757	8671	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E3257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036481	0.69892		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-38750	chr12	53646461	53646462	53252677	53252678	8672	hg38	N/A	N/A	N/A	Enhatls41930	enhancer	E3258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046163	0.69892		MFSD5	chr12	53251585	53254406	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4060
enhrx-9849	chr1	145455463	145455464	145979619	145979620	8673	hg38	N/A	enh603	fant2996	Enhatls10744	enhancer	E3259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0014439	0.70015		POLR3GL	chr1	145964689	145978848	493	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9848
enhrx-164450	chr9	36924176	36924177	36924179	36924180	8674	hg38	N/A	N/A	N/A	Enhatls175588	enhancer	E3260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13044	0.7006		PAX5	chr9	36833268	37034268	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1717
enhrx-57386	chr15	69869384	69869385	69577045	69577046	8675	hg38	N/A	enh52071	N/A	Enhatls61747	enhancer	E3261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015245	0.70061		RPLP1	chr15	69452813	69456205	118233	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4088
enhrx-32934	chr11	108354059	108354060	108483332	108483333	8676	hg38	N/A	enh14261	N/A	Enhatls35737	enhancer	E3262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10325	0.70061		POGLUT3	chr11	108472111	108498405	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7603
enhrx-3534	chr1	31210990	31210991	30738143	30738144	8677	hg38	N/A	N/A	N/A	Enhatls3909	enhancer	E3263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15918	0.70091		LAPTM5	chr1	30732468	30757774	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3533
enhrx-6304	chr1	61803786	61803787	61338114	61338115	8678	hg38	N/A	enh11931	N/A	Enhatls6877	enhancer	E3264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030593	0.70131		NFIA	chr1	60865258	61462788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6303
enhrx-117722	chr3	114403821	114403822	114684974	114684975	8679	hg38	N/A	N/A	N/A	Enhatls125993	enhancer	E3265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018219	0.70131		ZBTB20	chr3	114314499	115147292	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5851
enhrx-99583	chr2	217864712	217864713	216999989	216999990	8680	hg38	N/A	enh97068	N/A	Enhatls106542	enhancer	E3266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028143	0.70131		TNP1	chr2	216859457	216860064	137759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11509
enhrx-36077	chr12	12551397	12551398	12398463	12398464	8681	hg38	N/A	enh14533	N/A	Enhatls39124	enhancer	E3267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11718	0.70131		BORCS5	chr12	12357077	12471233	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1387
enhrx-140857	chr6	36880574	36880575	36912798	36912799	8682	hg38	N/A	enh49089	N/A	Enhatls150576	enhancer	E3268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10915	0.70176		C6orf89	chr6	36871869	36928964	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2445
enhrx-106708	chr21	33101475	33101476	31729162	31729163	8683	hg38	N/A	N/A	N/A	Enhatls114097	enhancer	E3269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038924	0.70176		SCAF4	chr21	31670999	31732118	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	591
enhrx-160690	chr8	102715241	102715242	101703013	101703014	8684	hg38	N/A	enh25185	N/A	Enhatls171640	enhancer	E3270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042392	0.70198		NCALD	chr8	101686541	102124907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4481
enhrx-170614	chrX	4848665	4848666	4930624	4930625	8685	hg38	N/A	enh85542	N/A	Enhatls182572	enhancer	E3271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1962	0.70225		NLGN4X	chrX	5890031	6228867	954998	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	331
enhrx-162828	chr9	935446	935447	935446	935447	8686	hg38	N/A	enh25414	N/A	Enhatls173896	enhancer	E3272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11579	0.70225		DMRT1	chr9	841696	969090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	95
enhrx-160909	chr8	108314953	108314954	107302725	107302726	8687	hg38	N/A	N/A	N/A	Enhatls171863	enhancer	E3273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056013	0.70225		ANGPT1	chr8	107249481	107498055	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4700
enhrx-104408	chr20	42606112	42606113	43977472	43977473	8688	hg38	N/A	enh6487	N/A	Enhatls111657	enhancer	E3274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21966	0.70225		TOX2	chr20	43914851	44069616	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2836
enhrx-20339	chr10	61296815	61296816	59537057	59537058	8689	hg38	N/A	enh28123	N/A	Enhatls22402	enhancer	E3275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0059818	0.70225		SLC16A9	chr10	59650763	59736002	110900	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2774
enhrx-130157	chr4	187768745	187768746	186847591	186847592	8690	hg38	N/A	enh37499	N/A	Enhatls139142	enhancer	E3276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016298	0.70225		FAT1	chr4	186587793	186726722	118888	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7701
enhrx-137670	chr5	172914390	172914391	173487387	173487388	8691	hg38	N/A	N/A	N/A	Enhatls147138	enhancer	E3277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045864	0.70225		BOD1	chr5	173607144	173616653	118896	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7461
enhrx-132391	chr5	60542062	60542063	61246235	61246236	8692	hg38	N/A	enh45860	N/A	Enhatls141489	enhancer	E3278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031141	0.70257		SMIM15	chr5	61157703	61162468	81171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2182
enhrx-107031	chr21	37560533	37560534	36188235	36188236	8693	hg38	N/A	enh53863	N/A	Enhatls114446	enhancer	E3279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0040448	0.70313		DOP1B	chr21	36156823	36294274	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	914
enhrx-52663	chr14	101228628	101228629	100762291	100762292	8694	hg38	N/A	enh31160	N/A	Enhatls56804	enhancer	E3280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015215	0.70326		DLK1	chr14	100725704	100738224	21241	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4620
enhrx-109311	chr22	27160063	27160064	26764100	26764101	8695	hg38	N/A	enh76793	N/A	Enhatls116979	enhancer	E3281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016432	0.70326		CRYBA4	chr22	26621962	26630669	130450	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1142
enhrx-158196	chr8	38367748	38367749	38510230	38510231	8696	hg38	N/A	N/A	N/A	Enhatls169020	enhancer	E3282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11741	0.7042		FGFR1	chr8	38411137	38468834	40124	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1987
enhrx-58151	chr15	78509211	78509212	78216869	78216870	8697	hg38	N/A	enh62504	N/A	Enhatls62567	enhancer	E3283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095588	0.70459		ACSBG1	chr15	78167467	78245688	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4853
enhrx-139050	chr6	17012938	17012939	17012707	17012708	8698	hg38	N/A	enh38842	N/A	Enhatls148662	enhancer	E3284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.008374	0.70465		STMND1	chr6	17102049	17131378	86549	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	638
enhrx-166232	chr9	97545711	97545712	94783429	94783430	8699	hg38	N/A	enh10840	N/A	Enhatls177913	enhancer	E3285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037377	0.70465		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3499
enhrx-89281	chr2	26800119	26800120	26577251	26577252	8700	hg38	N/A	N/A	N/A	Enhatls95640	enhancer	E3286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0091672	0.70465		CIMIP2C	chr2	26562584	26579532	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1207
enhrx-118648	chr3	128278504	128278505	128559661	128559662	8701	hg38	N/A	enh20915	N/A	Enhatls126965	enhancer	E3287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053376	0.70465		GATA2	chr3	128479426	128493201	55784	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6777
enhrx-112661	chr3	14448060	14448061	14406552	14406553	8702	hg38	N/A	enh7018	N/A	Enhatls120556	enhancer	E3288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024803	0.70465		SLC6A6	chr3	14402575	14489349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	790
enhrx-6127	chr1	56880582	56880583	56414910	56414911	8703	hg38	N/A	enh11909	N/A	Enhatls6671	enhancer	E3289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040209	0.70465		PLPP3	chr1	56494760	56579563	74238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6126
enhrx-148181	chr7	16707900	16707901	16668275	16668276	8704	hg38	N/A	enh23998	fant25642	Enhatls158354	enhancer	E3290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056916	0.70465		BZW2	chr7	16646130	16706523	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	993
enhrx-138694	chr6	7201596	7201597	7201363	7201364	8705	hg38	N/A	enh22974	N/A	Enhatls148277	enhancer	E3291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092895	0.70577		RREB1	chr6	7107596	7251980	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	282
enhrx-40734	chr12	85767569	85767570	85373791	85373792	8706	hg38	N/A	N/A	N/A	Enhatls44025	enhancer	E3292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062982	0.7063		ALX1	chr12	85280219	85301784	70234	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6044
enhrx-24869	chr10	128607051	128607052	126918482	126918483	8707	hg38	N/A	enh28541	N/A	Enhatls27226	enhancer	E3293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.19862	0.7063		DOCK1	chr10	126905408	127452517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7304
enhrx-85139	chr19	42603166	42603167	42099014	42099015	8708	hg38	N/A	N/A	N/A	Enhatls91266	enhancer	E3294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050796	0.70669		POU2F2	chr19	42086109	42196585	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6109
enhrx-138686	chr6	6601355	6601356	6601122	6601123	8709	hg38	N/A	enh22959	N/A	Enhatls148268	enhancer	E3295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039961	0.70669		LY86	chr6	6588107	6654983	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	274
enhrx-59435	chr15	99198263	99198264	98655034	98655035	8710	hg38	N/A	enh16455	N/A	Enhatls64001	enhancer	E3296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11347	0.7072		IGF1R	chr15	98648538	98964530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6137
enhrx-3142	chr1	27029028	27029029	26702537	26702538	8711	hg38	N/A	enh166	N/A	Enhatls3491	enhancer	E3297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13755	0.7072		ARID1A	chr1	26693235	26782104	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3141
enhrx-33307	chr11	115558834	115558835	115688116	115688117	8712	hg38	N/A	N/A	N/A	Enhatls36142	enhancer	E3298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074385	0.70757		CADM1	chr11	115169235	115504957	174061	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7976
enhrx-121847	chr3	189474472	189474473	189756683	189756684	8713	hg38	N/A	enh82910	N/A	Enhatls130400	enhancer	E3299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11618	0.70785		TP63	chr3	189631388	189897276	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9976
enhrx-15215	chr1	211242406	211242407	211069064	211069065	8714	hg38	N/A	N/A	N/A	Enhatls16737	enhancer	E3300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068149	0.70785		KCNH1	chr1	210676822	211134165	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15214
enhrx-118564	chr3	126806067	126806068	127087224	127087225	8715	hg38	N/A	N/A	N/A	Enhatls126874	enhancer	E3301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.044272	0.70785		PLXNA1	chr3	126982692	127037389	41944	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6693
enhrx-141264	chr6	42106828	42106829	42139090	42139091	8716	hg38	N/A	enh9110	N/A	Enhatls151022	enhancer	E3302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038657	0.70785		C6orf132	chr6	42101118	42142620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2852
enhrx-9487	chr1	117811638	117811639	117269016	117269017	8717	hg38	N/A	enh12196	N/A	Enhatls10254	enhancer	E3303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.20776	0.70803		VTCN1	chr1	117143586	117210960	54364	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9486
enhrx-91380	chr2	64871709	64871710	64644575	64644576	8718	hg38	N/A	enh5583	N/A	Enhatls97913	enhancer	E3304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059929	0.70803		SERTAD2	chr2	64631620	64653913	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3306
enhrx-89402	chr2	27516450	27516451	27293582	27293583	8719	hg38	N/A	enh33153	N/A	Enhatls95754	enhancer	E3305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12797	0.70817		TRIM54	chr2	27282428	27307439	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1328
enhrx-140519	chr6	34305845	34305846	34338068	34338069	8720	hg38	N/A	enh9064	N/A	Enhatls150223	enhancer	E3306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058422	0.70838		NUDT3	chr6	34279678	34392669	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2107
enhrx-140519	chr6	34305845	34305846	34338068	34338069	8721	hg38	N/A	enh9064	N/A	Enhatls150223	enhancer	E3306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058422	0.70838		RPS10-NUDT3	chr6	34284886	34426071	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2107
enhrx-50229	chr14	60689784	60689785	60223066	60223067	8722	hg38	N/A	enh86996	N/A	Enhatls54188	enhancer	E3307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11748	0.70838		PPM1A	chr14	60245751	60299087	20655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2186
enhrx-124440	chr4	42657988	42657989	42655971	42655972	8723	hg38	N/A	enh36567	N/A	Enhatls133167	enhancer	E3308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033358	0.70838		ATP8A1	chr4	42408372	42657121	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1984
enhrx-93430	chr2	101504431	101504432	100887969	100887970	8724	hg38	N/A	enh5745	N/A	Enhatls100063	enhancer	E3309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085223	0.70838		NPAS2	chr2	100820138	100996829	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5356
enhrx-109808	chr22	31975961	31975962	31579975	31579976	8725	hg38	N/A	enh93110	N/A	Enhatls117498	enhancer	E3310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.091475	0.70838		SFI1	chr22	31496138	31618588	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1639
enhrx-105684	chr20	60937146	60937147	62362090	62362091	8726	hg38	N/A	enh34758	N/A	Enhatls113038	enhancer	E3311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023496	0.70838		LAMA5	chr20	62309064	62367312	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4112
enhrx-31831	chr11	84899263	84899264	85188219	85188220	8727	hg38	N/A	enh96239	N/A	Enhatls34585	enhancer	E3312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051451	0.70838		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6500
enhrx-124306	chr4	40478625	40478626	40476608	40476609	8728	hg38	N/A	N/A	N/A	Enhatls133026	enhancer	E3313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094657	0.70838		RBM47	chr4	40423266	40630875	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1850
enhrx-166498	chr9	100652528	100652529	97890246	97890247	8729	hg38	N/A	enh98274	N/A	Enhatls178204	enhancer	E3314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090925	0.70838		TRMO	chr9	97904488	97922500	12196	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3765
enhrx-97036	chr2	173320080	173320081	172455352	172455353	8730	hg38	N/A	enh19021	N/A	Enhatls103853	enhancer	E3315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093265	0.70877		ITGA6	chr2	172427353	172506459	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8962
enhrx-lit79	chr6	157614761	157614762	157264870	157264871	8731	hg38					enhancer	E3316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18203	0.70898							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-119809	chr3	144736990	144736991	145018148	145018149	8732	hg38	N/A	N/A	N/A	Enhatls128186	enhancer	E3317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028601	0.70898		DIPK2A	chr3	143971822	143992368	1025106	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7938
enhrx-145356	chr6	135467953	135467954	135146815	135146816	8733	hg38	N/A	enh9366	N/A	Enhatls155353	enhancer	E3318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061382	0.70898		MYB	chr6	135181307	135219173	31411	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6944
enhrx-157047	chr8	19183670	19183671	19326159	19326160	8734	hg38	N/A	enh24792	N/A	Enhatls167773	enhancer	E3319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059337	0.70898		SH2D4A	chr8	19313692	19396218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	838
enhrx-142180	chr6	53827000	53827001	53962202	53962203	8735	hg38	N/A	enh39059	N/A	Enhatls152000	enhancer	E3320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01157	0.70898		MLIP	chr6	53929981	54266280	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3768
enhrx-159804	chr8	81525332	81525333	80613097	80613098	8736	hg38	N/A	enh66572	N/A	Enhatls170705	enhancer	E3321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040711	0.70898		ZNF704	chr8	80628450	80874781	11151	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3595
enhrx-51747	chr14	88365749	88365750	87899405	87899406	8737	hg38	N/A	enh3390	N/A	Enhatls55808	enhancer	E3322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033077	0.70898		GALC	chr14	87933013	87993665	31821	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3704
enhrx-149729	chr7	46926330	46926331	46886732	46886733	8738	hg38	N/A	N/A	N/A	Enhatls160039	enhancer	E3323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031703	0.70922		TNS3	chr7	47275153	47582558	376942	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-161710	chr8	131495717	131495718	130483471	130483472	8739	hg38	N/A	enh25329	N/A	Enhatls172740	enhancer	E3324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074354	0.70964		ASAP1	chr8	130052103	130443674	39765	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5501
enhrx-24269	chr10	120282410	120282411	118522898	118522899	8740	hg38	N/A	enh13550	N/A	Enhatls26622	enhancer	E3325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082248	0.70964		PRLHR	chr10	118589996	118595648	63808	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6704
enhrx-160634	chr8	101470006	101470007	100457778	100457779	8741	hg38	N/A	enh46618	N/A	Enhatls171576	enhancer	E3326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027135	0.71026		ANKRD46	chr8	100509751	100559784	48952	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4425
enhrx-161143	chr8	116731224	116731225	115718998	115718999	8742	hg38	N/A	enh85196	N/A	Enhatls172101	enhancer	E3327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15275	0.71026		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4934
enhrx-9361	chr1	115753324	115753325	115210703	115210704	8743	hg38	N/A	enh12176	N/A	Enhatls10100	enhancer	E3328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081221	0.71026		NGF	chr1	115285903	115338770	66365	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9360
enhrx-77200	chr18	24198192	24198193	26618228	26618229	8744	hg38	N/A	enh17618	N/A	Enhatls82852	enhancer	E3329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050512	0.71026		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1218
enhrx-134820	chr5	118754656	118754657	119418961	119418962	8745	hg38	N/A	enh22527	N/A	Enhatls144017	enhancer	E3330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08109	0.71026		TNFAIP8	chr5	119268691	119399688	15107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-116097	chr3	59306133	59306134	59320407	59320408	8746	hg38	N/A	enh82540	N/A	Enhatls124228	enhancer	E3331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022218	0.71026		CFAP20DC	chr3	58717364	59050084	268176	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4226
enhrx-99327	chr2	212046696	212046697	211181971	211181972	8747	hg38	N/A	N/A	N/A	Enhatls106262	enhancer	E3332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031585	0.71027		ERBB4	chr2	211375716	212538841	173782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11253
enhrx-11162	chr1	156488534	156488535	156518742	156518743	8748	hg38	N/A	enh43055	N/A	Enhatls12415	enhancer	E3333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06313	0.71027		IQGAP3	chr1	156525404	156572565	5342	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11161
enhrx-107089	chr21	37881349	37881350	36509051	36509052	8749	hg38	N/A	enh19942	N/A	Enhatls114510	enhancer	E3334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03943	0.71027		CLDN14	chr21	36460620	36576569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	972
enhrx-114820	chr3	48934954	48934955	48897521	48897522	8750	hg38	N/A	N/A	N/A	Enhatls122862	enhancer	E3335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047851	0.71027		SLC25A20	chr3	48856925	48898904	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2949
enhrx-161060	chr8	112794233	112794234	111782004	111782005	8751	hg38	N/A	N/A	N/A	Enhatls172016	enhancer	E3336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025652	0.71027		CSMD3	chr8	112222927	113436939	428592	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4851
enhrx-96375	chr2	164591948	164591949	163735438	163735439	8752	hg38	N/A	N/A	N/A	Enhatls103166	enhancer	E3337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11687	0.71049		FIGN	chr2	163593395	163736012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8301
enhrx-135457	chr5	132835749	132835750	133500058	133500059	8753	hg38	N/A	N/A	N/A	Enhatls144702	enhancer	E3338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1239	0.71049		FSTL4	chr5	133196454	133612541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5248
enhrx-34362	chr11	126197504	126197505	126327609	126327610	8754	hg38	N/A	enh14373	N/A	Enhatls37269	enhancer	E3339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10662	0.71103		DCPS	chr11	126304059	126350005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9031
enhrx-141077	chr6	39219473	39219474	39251697	39251698	8755	hg38	N/A	enh23216	N/A	Enhatls150817	enhancer	E3340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13797	0.71104		KCNK5	chr6	39188970	39229475	12425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2665
enhrx-24391	chr10	122012868	122012869	120253356	120253357	8756	hg38	N/A	enh79755	N/A	Enhatls26761	enhancer	E3341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013025	0.71114		PLPP4	chr10	120457226	120592065	201744	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6826
enhrx-65833	chr16	77904555	77904556	77870658	77870659	8757	hg38	N/A	enh64977	N/A	Enhatls70643	enhancer	E3342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071254	0.71114		VAT1L	chr16	77788563	77980107	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6128
enhrx-102853	chr20	21663416	21663417	21682778	21682779	8758	hg38	N/A	enh97116	N/A	Enhatls109976	enhancer	E3343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011215	0.71114		PAX1	chr20	21705658	21718481	20782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1281
enhrx-76955	chr18	20646799	20646800	23066835	23066836	8759	hg38	N/A	enh48107	N/A	Enhatls82574	enhancer	E3344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067311	0.71114		RBBP8	chr18	22798260	23026488	37694	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	973
enhrx-11394	chr1	157998962	157998963	158029172	158029173	8760	hg38	N/A	enh12308	N/A	Enhatls12675	enhancer	E3345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048717	0.71138		KIRREL1	chr1	157993272	158100262	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11393
enhrx-24216	chr10	118762995	118762996	117003484	117003485	8761	hg38	N/A	N/A	N/A	Enhatls26570	enhancer	E3346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078648	0.71142		SHTN1	chr10	116881476	117126586	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6651
enhrx-133314	chr5	76469066	76469067	77173241	77173242	8762	hg38	N/A	enh37992	N/A	Enhatls142434	enhancer	E3347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0089575	0.71208		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3105
enhrx-6754	chr1	67842252	67842253	67376569	67376570	8763	hg38	N/A	enh95858	N/A	Enhatls7352	enhancer	E3348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018244	0.7122		IL12RB2	chr1	67307363	67398724	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6753
enhrx-84423	chr19	39144189	39144190	38653549	38653550	8764	hg38	N/A	enh5125	N/A	Enhatls90486	enhancer	E3349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13837	0.7122		ACTN4	chr19	38647648	38731589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5393
enhrx-167329	chr9	115603706	115603707	112841426	112841427	8765	hg38	N/A	N/A	N/A	Enhatls179082	enhancer	E3350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11069	0.7122		SNX30	chr9	112750759	112874987	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4596
enhrx-93388	chr2	100273583	100273584	99657121	99657122	8766	hg38	N/A	enh33506	N/A	Enhatls100017	enhancer	E3351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13092	0.7122		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5314
enhrx-64526	chr16	65923501	65923502	65889598	65889599	8767	hg38	N/A	enh81133	N/A	Enhatls69259	enhancer	E3352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2672	0.71298		CDH5	chr16	66366690	66404784	474959	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4821
enhrx-19161	chr10	30831323	30831324	30542394	30542395	8768	hg38	N/A	enh1156	fant35288	Enhatls20944	enhancer	E3353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12858	0.71298		LYZL2	chr10	30611778	30629762	68736	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1596
enhrx-91414	chr2	66467546	66467547	66240414	66240415	8769	hg38	N/A	enh18620	N/A	Enhatls97957	enhancer	E3354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20803	0.71298		MEIS1	chr2	66435124	66573869	190002	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3340
enhrx-138729	chr6	7419473	7419474	7419240	7419241	8770	hg38	N/A	enh66160	N/A	Enhatls148312	enhancer	E3355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39302	0.71298		RIOK1	chr6	7389807	7418037	1178	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	317
enhrx-45826	chr13	44792793	44792794	44218657	44218658	8771	hg38	N/A	enh30300	N/A	Enhatls49459	enhancer	E3356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29349	0.71298			chr13	44143149	44161257	55133	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1448
enhrx-161954	chr8	138845721	138845722	137833478	137833479	8772	hg38	N/A	N/A	N/A	Enhatls173002	enhancer	E3357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029293	0.71298		FAM135B	chr8	138130022	138497261	271569	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5745
enhrx-154181	chr7	129041440	129041441	129401599	129401600	8773	hg38	N/A	N/A	N/A	Enhatls164751	enhancer	E3358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06198	0.71354		AHCYL2	chr7	129225029	129430211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6993
enhrx-13237	chr1	182187271	182187272	182218136	182218137	8774	hg38	N/A	enh27297	N/A	Enhatls14610	enhancer	E3359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096017	0.71447		ZNF648	chr1	182054569	182061712	152239	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-75892	chr17	80526469	80526470	82568593	82568594	8775	hg38	N/A	N/A	N/A	Enhatls81437	enhancer	E3360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11115	0.71447		FOXK2	chr17	82519731	82604602	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9161
enhrx-41515	chr12	102339326	102339327	101945548	101945549	8776	hg38	N/A	enh14928	N/A	Enhatls44860	enhancer	E3361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056096	0.71449		DRAM1	chr12	101877579	102012130	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6825
enhrx-6976	chr1	74898210	74898211	74432526	74432527	8777	hg38	N/A	N/A	N/A	Enhatls7583	enhancer	E3362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084346	0.7153		TNNI3K	chr1	74235386	74544428	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6975
enhrx-6976	chr1	74898210	74898211	74432526	74432527	8778	hg38	N/A	N/A	N/A	Enhatls7583	enhancer	E3362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084346	0.7153		FPGT-TNNI3K	chr1	74198234	74543982	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6975
enhrx-14031	chr1	200504921	200504922	200535793	200535794	8779	hg38	N/A	enh95958	N/A	Enhatls15464	enhancer	E3363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076144	0.7153		KIF14	chr1	200551496	200620751	13630	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14030
enhrx-129550	chr4	169991345	169991346	169070194	169070195	8780	hg38	N/A	enh21934	fant17369	Enhatls138489	enhancer	E3364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031536	0.7153		SH3RF1	chr4	169094258	169270956	23993	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7094
enhrx-25329	chr10	135430523	135430524	133617019	133617020	8781	hg38	N/A	enh87841	N/A	Enhatls27665	enhancer	E3365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19484	0.71664		FRG2B	chr10	133623894	133626795	4804	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7764
enhrx-54246	chr15	34475389	34475390	34183188	34183189	8782	hg38	N/A	enh3515	N/A	Enhatls58425	enhancer	E3366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.003487	0.71664		KATNBL1	chr15	34140673	34210096	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	948
enhrx-48782	chr14	26750999	26751000	26281793	26281794	8783	hg38	N/A	enh30739	N/A	Enhatls52663	enhancer	E3367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059631	0.71664		NOVA1	chr14	26443089	26598033	153981	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	739
enhrx-6128	chr1	57035471	57035472	56569798	56569799	8784	hg38	N/A	enh11912	N/A	Enhatls6676	enhancer	E3368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13111	0.7168		PLPP3	chr1	56494760	56579563	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6127
enhrx-33127	chr11	112112495	112112496	112241772	112241773	8785	hg38	N/A	enh29146	N/A	Enhatls35951	enhancer	E3369	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16284	0.71803		PLET1	chr11	112248152	112260860	4344	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7796
enhrx-167694	chr9	122631162	122631163	119868884	119868885	8786	hg38	N/A	N/A	N/A	Enhatls179480	enhancer	E3370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067191	0.71814		BRINP1	chr9	119166628	119369435	499190	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4961
enhrx-165469	chr9	80783470	80783471	78168554	78168555	8787	hg38	N/A	enh98249	N/A	Enhatls177078	enhancer	E3371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0049711	0.71856		CEP78	chr9	78236061	78279690	66463	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2736
enhrx-46756	chr13	77665330	77665331	77091195	77091196	8788	hg38	N/A	N/A	N/A	Enhatls50478	enhancer	E3372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048376	0.71856		MYCBP2	chr13	77042473	77327094	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2378
enhrx-37544	chr12	43316033	43316034	42922230	42922231	8789	hg38	N/A	enh57603	N/A	Enhatls40659	enhancer	E3373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028995	0.71856		PRICKLE1	chr12	42456756	42590355	326027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2854
enhrx-62376	chr16	23916598	23916599	23905277	23905278	8790	hg38	N/A	enh31737	N/A	Enhatls67008	enhancer	E3374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087412	0.71867		PRKCB	chr16	23835982	24220611	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2671
enhrx-20510	chr10	67106447	67106448	65346689	65346690	8791	hg38	N/A	N/A	N/A	Enhatls22599	enhancer	E3375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026626	0.71867		CTNNA3	chr10	65912456	67763637	555770	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2945
enhrx-8074	chr1	95000325	95000326	94534769	94534770	8792	hg38	N/A	N/A	N/A	Enhatls8745	enhancer	E3376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030062	0.71937		F3	chr1	94529172	94541759	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8073
enhrx-94582	chr2	121106164	121106165	120348588	120348589	8793	hg38	N/A	N/A	N/A	Enhatls101276	enhancer	E3377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012492	0.71938		INHBB	chr2	120346135	120351803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6508
enhrx-37206	chr12	33484070	33484071	33331135	33331136	8794	hg38	N/A	N/A	N/A	Enhatls40316	enhancer	E3378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22584	0.71987		SYT10	chr12	33374237	33439819	9348	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2516
enhrx-110262	chr22	37798278	37798279	37402238	37402239	8795	hg38	N/A	enh86445	N/A	Enhatls117991	enhancer	E3379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020376	0.71997		ELFN2	chr22	37367959	37427479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2093
enhrx-92353	chr2	85476525	85476526	85249402	85249403	8796	hg38	N/A	enh18700	N/A	Enhatls98942	enhancer	E3380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1106	0.71997		TCF7L1	chr2	85133391	85310387	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4279
enhrx-89578	chr2	28932157	28932158	28709291	28709292	8797	hg38	N/A	enh18396	N/A	Enhatls95960	enhancer	E3381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0038313	0.72026		PPP1CB	chr2	28751639	28802940	37946	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1504
enhrx-103162	chr20	30296718	30296719	31708915	31708916	8798	hg38	N/A	enh19573	N/A	Enhatls110296	enhancer	E3382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058129	0.72041		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-45312	chr13	34909922	34909923	34335785	34335786	8799	hg38	N/A	enh68365	N/A	Enhatls48912	enhancer	E3383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032142	0.72045		RFC3	chr13	33818068	33966558	362197	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	934
enhrx-129302	chr4	162507869	162507870	161586717	161586718	8800	hg38	N/A	enh37298	N/A	Enhatls138226	enhancer	E3384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0023104	0.72045		FSTL5	chr4	161383896	162164004	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6846
enhrx-26989	chr11	17435379	17435380	17413832	17413833	8801	hg38	hs1977	N/A	N/A	Enhatls29417	enhancer	E3385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066184	0.72045		ABCC8	chr11	17392497	17476872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1658
enhrx-107089	chr21	37872361	37872362	36500063	36500064	8802	hg38	N/A	enh19942	N/A	Enhatls114510	enhancer	E3386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14019	0.72054		CLDN14	chr21	36460620	36576569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	972
enhrx-50605	chr14	66415197	66415198	65948479	65948480	8803	hg38	N/A	enh30975	N/A	Enhatls54583	enhancer	E3387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30547	0.72054		FUT8	chr14	65410591	65744121	204187	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2562
enhrx-78989	chr18	77551441	77551442	79791441	79791442	8804	hg38	N/A	enh32867	N/A	Enhatls84739	enhancer	E3388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082027	0.72125		KCNG2	chr18	79797937	79900100	6240	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3007
enhrx-40888	chr12	92211410	92211411	91817634	91817635	8805	hg38	N/A	enh62290	N/A	Enhatls44185	enhancer	E3389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017506	0.72199		BTG1	chr12	92140277	92145846	318999	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6198
enhrx-138101	chr5	177826617	177826618	178399616	178399617	8806	hg38	N/A	enh49019	N/A	Enhatls147636	enhancer	E3390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10441	0.72199		COL23A1	chr5	178237475	178590393	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7892
enhrx-71234	chr17	39957887	39957888	41801635	41801636	8807	hg38	N/A	N/A	N/A	Enhatls76432	enhancer	E3391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09236	0.72199		P3H4	chr17	41801946	41812604	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4503
enhrx-32941	chr11	108457624	108457625	108586897	108586898	8808	hg38	N/A	enh14266	N/A	Enhatls35745	enhancer	E3392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027128	0.72199		EXPH5	chr11	108505434	108593768	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7610
enhrx-123606	chr4	16046011	16046012	16044388	16044389	8809	hg38	N/A	enh77238	N/A	Enhatls132285	enhancer	E3393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049461	0.72199		PROM1	chr4	15968227	16084378	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1150
enhrx-54441	chr15	39318344	39318345	39026143	39026144	8810	hg38	N/A	N/A	N/A	Enhatls58634	enhancer	E3394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10844	0.72199		RASGRP1	chr15	38488102	38565575	455717	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1143
enhrx-126869	chr4	96386349	96386350	95465198	95465199	8811	hg38	N/A	enh83219	N/A	Enhatls135705	enhancer	E3395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20783	0.72201		UNC5C	chr4	95162503	95549206	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4413
enhrx-84252	chr19	38781721	38781722	38291081	38291082	8812	hg38	N/A	N/A	N/A	Enhatls90312	enhancer	E3396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1253	0.72201		SPINT2	chr19	38244034	38292615	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5222
enhrx-42358	chr12	111142768	111142769	110704963	110704964	8813	hg38	N/A	N/A	N/A	Enhatls45755	enhancer	E3397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11137	0.72201		HVCN1	chr12	110627840	110704950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7668
enhrx-104220	chr20	39715748	39715749	41087108	41087109	8814	hg38	N/A	enh53763	N/A	Enhatls111468	enhancer	E3398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073687	0.72345		TOP1	chr20	41028821	41124487	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2648
enhrx-65567	chr16	72875719	72875720	72841820	72841821	8815	hg38	N/A	enh16764	N/A	Enhatls70358	enhancer	E3399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12892	0.7238		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5862
enhrx-106690	chr21	32797767	32797768	31425454	31425455	8816	hg38	N/A	enh70376	N/A	Enhatls114076	enhancer	E3400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.17426	0.7238		TIAM1	chr21	31118415	31558977	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	573
enhrx-166961	chr9	111330614	111330615	108568334	108568335	8817	hg38	N/A	enh59993	N/A	Enhatls178703	enhancer	E3401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07623	0.72479		ACTL7B	chr9	108854587	108855986	282673	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-116343	chr3	67612595	67612596	67562171	67562172	8818	hg38	N/A	enh7298	N/A	Enhatls124505	enhancer	E3402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081188	0.72505		SUCLG2	chr3	67360459	67654612	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4472
enhrx-162837	chr9	1462896	1462897	1462896	1462897	8819	hg38	N/A	enh59925	N/A	Enhatls173904	enhancer	E3403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039892	0.72542		DMRT2	chr9	1049857	1057552	399016	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	104
enhrx-76077	chr18	2096931	2096932	2096930	2096931	8820	hg38	N/A	N/A	N/A	Enhatls81630	enhancer	E3404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13078	0.72542		METTL4	chr18	2537524	2571509	432816	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	95
enhrx-90845	chr2	54216847	54216848	53989710	53989711	8821	hg38	N/A	enh5524	N/A	Enhatls97332	enhancer	E3405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095703	0.72542		ACYP2	chr2	53970837	54305300	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2771
enhrx-77153	chr18	22285392	22285393	24705428	24705429	8822	hg38	N/A	N/A	N/A	Enhatls82800	enhancer	E3406	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04521	0.72542		HRH4	chr18	24460636	24479961	196571	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1171
enhrx-35342	chr12	6845149	6845150	6735983	6735984	8823	hg38	N/A	enh58400	N/A	Enhatls38370	enhancer	E3407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024882	0.72542		COPS7A	chr12	6724013	6731875	965	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	652
enhrx-168190	chr9	128356745	128356746	125594466	125594467	8824	hg38	N/A	N/A	N/A	Enhatls180022	enhancer	E3408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055387	0.72542		MAPKAP1	chr9	125437392	125707234	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5457
enhrx-18115	chr10	12192345	12192346	12150346	12150347	8825	hg38	N/A	N/A	N/A	Enhatls19800	enhancer	E3409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14475	0.72542		SEC61A2	chr10	12129636	12169956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	550
enhrx-45117	chr13	31648609	31648610	31074472	31074473	8826	hg38	N/A	enh43899	N/A	Enhatls48686	enhancer	E3410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087887	0.72542		HSPH1	chr13	31134972	31162388	57995	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	739
enhrx-90584	chr2	46219682	46219683	45992543	45992544	8827	hg38	N/A	enh5486	N/A	Enhatls97043	enhancer	E3411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041353	0.72542		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2510
enhrx-77543	chr18	33505913	33505914	35925950	35925951	8828	hg38	N/A	enh4790	N/A	Enhatls83200	enhancer	E3412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017756	0.72544		C18orf21	chr18	35972624	35979286	46074	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1561
enhrx-30642	chr11	67844302	67844303	68076835	68076836	8829	hg38	N/A	enh96219	N/A	Enhatls33313	enhancer	E3413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028759	0.72544		CHKA	chr11	68052858	68121444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5311
enhrx-165462	chr9	80278896	80278897	77663980	77663981	8830	hg38	N/A	enh49496	N/A	Enhatls177071	enhancer	E3414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018414	0.7258		GNA14	chr9	77423078	77648322	8228	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2729
enhrx-153821	chr7	123262850	123262851	123622796	123622797	8831	hg38	N/A	N/A	N/A	Enhatls164380	enhancer	E3415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019449	0.72631		ASB15	chr7	123567009	123639481	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6633
enhrx-163683	chr9	22343059	22343060	22343060	22343061	8832	hg38	N/A	enh41819	N/A	Enhatls174782	enhancer	E3416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055479	0.72645		DMRTA1	chr9	22446823	22455740	101688	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	950
enhrx-141844	chr6	47599626	47599627	47631890	47631891	8833	hg38	N/A	enh49110	N/A	Enhatls151649	enhancer	E3417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0058986	0.72645		CD2AP	chr6	47477788	47627263	2107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3432
enhrx-9162	chr1	113822945	113822946	113280323	113280324	8834	hg38	N/A	enh49946	N/A	Enhatls9894	enhancer	E3418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11357	0.72645		MAGI3	chr1	113390514	113685923	105165	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9161
enhrx-72143	chr17	45369013	45369014	47291647	47291648	8835	hg38	hs2033	N/A	N/A	Enhatls77423	enhancer	E3419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078387	0.72702		ITGB3	chr17	47253826	47313743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5412
enhrx-114056	chr3	43029812	43029813	42988320	42988321	8836	hg38	N/A	N/A	N/A	Enhatls122056	enhancer	E3420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.154	0.72711		GASK1A	chr3	42979086	43059311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2185
enhrx-90163	chr2	38300586	38300587	38073443	38073444	8837	hg38	N/A	N/A	N/A	Enhatls96584	enhancer	E3421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11443	0.72711		CYP1B1	chr2	38067508	38109902	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2089
enhrx-102703	chr20	19264264	19264265	19283620	19283621	8838	hg38	N/A	enh76652	N/A	Enhatls109816	enhancer	E3422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013177	0.72711		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1131
enhrx-77609	chr18	34274128	34274129	36694165	36694166	8839	hg38	N/A	N/A	N/A	Enhatls83268	enhancer	E3423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093634	0.72711		FHOD3	chr18	36297712	36780220	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1627
enhrx-126911	chr4	99495121	99495122	98573970	98573971	8840	hg38	N/A	N/A	N/A	Enhatls135749	enhancer	E3424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0048479	0.72711		TSPAN5	chr4	98470366	98658611	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4455
enhrx-56386	chr15	58025162	58025163	57732964	57732965	8841	hg38	N/A	enh44123	N/A	Enhatls60668	enhancer	E3425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095725	0.72742		POLR2M	chr15	57706713	57717557	1091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3088
enhrx-6450	chr1	63657343	63657344	63191672	63191673	8842	hg38	N/A	enh66963	N/A	Enhatls7024	enhancer	E3426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19749	0.72742		FOXD3	chr1	63322566	63325128	130612	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6449
enhrx-101922	chr20	3203702	3203703	3223056	3223057	8843	hg38	N/A	N/A	N/A	Enhatls108984	enhancer	E3427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.034154	0.72777		ITPA	chr20	3209497	3223870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	350
enhrx-68897	chr17	18032581	18032582	18129267	18129268	8844	hg38	N/A	N/A	fant52104	Enhatls73932	enhancer	E3428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039964	0.72777		MYO15A	chr17	18108755	18179800	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2166
enhrx-113447	chr3	34077727	34077728	34036235	34036236	8845	hg38	N/A	enh97253	N/A	Enhatls121389	enhancer	E3429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12613	0.7279		PDCD6IP	chr3	33798570	33869707	164447	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1576
enhrx-38658	chr12	53289186	53289187	52895402	52895403	8846	hg38	N/A	enh109553	fant41794	Enhatls41825	enhancer	E3430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11398	0.7279		KRT8	chr12	52897186	52949882	1543	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3968
enhrx-64071	chr16	56841063	56841064	56807151	56807152	8847	hg38	N/A	enh4045	N/A	Enhatls68770	enhancer	E3431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.092142	0.7279		NUP93	chr16	56730117	56850286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4366
enhrx-168507	chr9	131061131	131061132	128298852	128298853	8848	hg38	N/A	enh86759	N/A	Enhatls180363	enhancer	E3432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14645	0.7279		TRUB2	chr9	128305158	128322447	2877	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5774
enhrx-118804	chr3	129631810	129631811	129912967	129912968	8849	hg38	N/A	N/A	N/A	Enhatls127148	enhancer	E3433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015992	0.7279		TMCC1	chr3	129647791	129893711	16982	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6933
enhrx-48932	chr14	31699049	31699050	31229843	31229844	8850	hg38	N/A	enh15552	fant45682	Enhatls52826	enhancer	E3434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067428	0.7279		HECTD1	chr14	31100116	31207804	21841	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	889
enhrx-63904	chr16	54199518	54199519	54165606	54165607	8851	hg38	N/A	enh92675	N/A	Enhatls68587	enhancer	E3435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1188	0.7279		FTO	chr16	53701691	54153448	5646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4199
enhrx-165158	chr9	74398451	74398452	71783535	71783536	8852	hg38	N/A	enh25593	N/A	Enhatls176750	enhancer	E3436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10329	0.7279		CEMIP2	chr9	71683365	71816690	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2425
enhrx-13366	chr1	183344146	183344147	183375011	183375012	8853	hg38	N/A	enh12452	N/A	Enhatls14760	enhancer	E3437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09921	0.7279		NMNAT2	chr1	183248236	183418380	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13365
enhrx-812	chr1	6410650	6410651	6350590	6350591	8854	hg38	N/A	enh11442	N/A	Enhatls851	enhancer	E3438	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081806	0.7279		ACOT7	chr1	6264268	6393767	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	811
enhrx-19937	chr10	49503823	49503824	48295780	48295781	8855	hg38	N/A	enh13195	N/A	Enhatls21897	enhancer	E3439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30449	0.7279		MAPK8	chr10	48306638	48439360	10027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2372
enhrx-119488	chr3	139021372	139021373	139302530	139302531	8856	hg38	N/A	enh35908	N/A	Enhatls127858	enhancer	E3440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13286	0.7279		MRPS22	chr3	139005805	139360497	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7617
enhrx-8366	chr1	102263514	102263515	101797958	101797959	8857	hg38	N/A	N/A	N/A	Enhatls9060	enhancer	E3441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12571	0.7279		OLFM3	chr1	101802559	101996926	89	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8365
enhrx-41545	chr12	102909476	102909477	102515698	102515699	8858	hg38	N/A	enh86947	N/A	Enhatls44890	enhancer	E3442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1023	0.72837		IGF1	chr12	102395873	102481744	29495	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6855
enhrx-83417	chr19	32063923	32063924	31573017	31573018	8859	hg38	N/A	enh96838	N/A	Enhatls89464	enhancer	E3443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10108	0.7299		TSHZ3	chr19	31274944	31349436	221544	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4387
enhrx-112483	chr3	12271642	12271643	12230142	12230143	8860	hg38	N/A	enh20333	N/A	Enhatls120363	enhancer	E3444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057944	0.7299		SYN2	chr3	12004387	12192032	27734	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	612
enhrx-107184	chr21	38937285	38937286	37564983	37564984	8861	hg38	N/A	enh59125	N/A	Enhatls114616	enhancer	E3445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016232	0.7299		DYRK1A	chr21	37365572	37526358	38613	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1067
enhrx-137677	chr5	173208609	173208610	173781606	173781607	8862	hg38	N/A	enh8886	N/A	Enhatls147148	enhancer	E3446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012858	0.7299		CPEB4	chr5	173888348	173961980	106441	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7468
enhrx-115797	chr3	55816623	55816624	55782595	55782596	8863	hg38	N/A	enh97266	N/A	Enhatls123893	enhancer	E3447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01897	0.7299		ERC2	chr3	55508310	56469095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3926
enhrx-138622	chr6	4621355	4621356	4621121	4621122	8864	hg38	N/A	enh22942	N/A	Enhatls148198	enhancer	E3448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06365	0.7299		CDYL	chr6	4706158	4955551	78778	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	210
enhrx-166961	chr9	110303969	110303970	107541688	107541689	8865	hg38	N/A	enh25859	N/A	Enhatls178703	enhancer	E3449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032546	0.7299		KLF4	chr9	107484851	107490482	40943	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-137620	chr5	171847661	171847662	172420657	172420658	8866	hg38	N/A	enh22806	N/A	Enhatls147082	enhancer	E3450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064498	0.7299		SH3PXD2B	chr5	172324999	172454525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7411
enhrx-160933	chr8	109280236	109280237	108268007	108268008	8867	hg38	N/A	N/A	N/A	Enhatls171887	enhancer	E3451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1083	0.72993		EIF3E	chr8	108162786	108443496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4724
enhrx-24098	chr10	117804510	117804511	116044999	116045000	8868	hg38	N/A	enh64385	N/A	Enhatls26453	enhancer	E3452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012614	0.72993		GFRA1	chr10	116056924	116276803	9701	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6533
enhrx-123818	chr4	24806903	24806904	24805281	24805282	8869	hg38	N/A	N/A	N/A	Enhatls132504	enhancer	E3453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028253	0.72993		CCDC149	chr4	24803513	24980148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1362
enhrx-162775	chr9	336199	336200	336199	336200	8870	hg38	N/A	N/A	N/A	Enhatls173839	enhancer	E3454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010682	0.72993		DOCK8	chr9	214864	465259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	42
enhrx-90148	chr2	37677376	37677377	37450233	37450234	8871	hg38	N/A	enh33220	N/A	Enhatls96563	enhancer	E3455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087876	0.72993		QPCT	chr2	37342826	37373322	73141	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2074
enhrx-110931	chr22	42069401	42069402	41673397	41673398	8872	hg38	N/A	N/A	N/A	Enhatls118698	enhancer	E3456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080442	0.72993		SNU13	chr22	41673932	41690504	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2762
enhrx-91021	chr2	56066497	56066498	55839362	55839363	8873	hg38	N/A	enh18571	fant7127	Enhatls97528	enhancer	E3457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2073	0.72993		EFEMP1	chr2	55865966	55924139	26494	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2947
enhrx-93672	chr2	105791918	105791919	105175461	105175462	8874	hg38	N/A	N/A	N/A	Enhatls100315	enhancer	E3458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013295	0.72993		MRPS9	chr2	105038068	105099960	48083	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5598
enhrx-170665	chrX	7080329	7080330	7162288	7162289	8875	hg38	N/A	enh11098	N/A	Enhatls182630	enhancer	E3459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04251	0.72993		STS	chrX	7147290	7453758	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	382
enhrx-134266	chr5	101331515	101331516	101995811	101995812	8876	hg38	N/A	enh55401	N/A	Enhatls143436	enhancer	E3460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10555	0.72993		SLCO4C1	chr5	102233985	102296284	236115	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4057
enhrx-112156	chr3	9140530	9140531	9098846	9098847	8877	hg38	N/A	N/A	N/A	Enhatls120019	enhancer	E3461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04866	0.72993		SRGAP3	chr3	8980590	9249646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	285
enhrx-107080	chr21	37774838	37774839	36402540	36402541	8878	hg38	N/A	N/A	N/A	Enhatls114500	enhancer	E3462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012859	0.72993		CHAF1B	chr21	36385391	36419015	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	963
enhrx-49453	chr14	49274748	49274749	48805545	48805546	8879	hg38	N/A	N/A	N/A	Enhatls53354	enhancer	E3463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063856	0.73032		RPS29	chr14	49570983	49598690	757161	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1410
enhrx-153250	chr7	107592014	107592015	107951569	107951570	8880	hg38	N/A	N/A	N/A	Enhatls163769	enhancer	E3464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018758	0.73032		LAMB1	chr7	107923798	108003213	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6062
enhrx-93894	chr2	110402403	110402404	109644826	109644827	8881	hg38	N/A	enh18798	N/A	Enhatls100565	enhancer	E3465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13882	0.73032		SOWAHC	chr2	109614363	109618990	17515	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5820
enhrx-145757	chr6	144585533	144585534	144264397	144264398	8882	hg38	N/A	enh9409	fant24507	Enhatls155801	enhancer	E3466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0073445	0.73032		UTRN	chr6	144285334	144853034	20771	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7345
enhrx-138304	chr5	179891788	179891789	180464788	180464789	8883	hg38	N/A	enh84059	N/A	Enhatls147859	enhancer	E3467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041685	0.73052		CNOT6	chr5	180494378	180578358	29328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8095
enhrx-141263	chr6	42086466	42086467	42118728	42118729	8884	hg38	N/A	enh23246	fant22602	Enhatls151021	enhancer	E3468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091003	0.73052		C6orf132	chr6	42101118	42142620	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2851
enhrx-110881	chr22	41814445	41814446	41418441	41418442	8885	hg38	N/A	enh6886	N/A	Enhatls118649	enhancer	E3469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086834	0.73052		TOB2	chr22	41433493	41446801	5543	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2712
enhrx-69389	chr17	25568824	25568825	27241798	27241799	8886	hg38	N/A	enh17059	N/A	Enhatls74488	enhancer	E3470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081878	0.73052		WSB1	chr17	27294075	27315926	49468	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2658
enhrx-107023	chr21	37486111	37486112	36113813	36113814	8887	hg38	N/A	enh19937	fant60124	Enhatls114439	enhancer	E3471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033479	0.73052		CBR3	chr21	36135078	36146562	21158	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	906
enhrx-61737	chr16	19150012	19150013	19138690	19138691	8888	hg38	N/A	enh16588	N/A	Enhatls66348	enhancer	E3472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076366	0.73052		ITPRIPL2	chr16	19113963	19121629	5295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-73201	chr17	57930720	57930721	59853359	59853360	8889	hg38	N/A	enh17263	fant53211	Enhatls78584	enhancer	E3473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013141	0.73052		TUBD1	chr17	59859478	59892945	5814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6470
enhrx-61737	chr16	19133377	19133378	19122055	19122056	8890	hg38	N/A	enh81095	N/A	Enhatls66348	enhancer	E3474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085449	0.73052		ITPRIPL2	chr16	19113963	19121629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-21513	chr10	80848214	80848215	79088457	79088458	8891	hg38	N/A	enh1378	N/A	Enhatls23676	enhancer	E3475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041163	0.73052		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3948
enhrx-146133	chr6	152017992	152017993	151696857	151696858	8892	hg38	N/A	enh9453	N/A	Enhatls156205	enhancer	E3476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018093	0.73052		ESR1	chr6	151690495	152129619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7721
enhrx-70993	chr17	38605125	38605126	40448873	40448874	8893	hg38	N/A	enh52499	N/A	Enhatls76172	enhancer	E3477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1848	0.73052		IGFBP4	chr17	40443449	40457725	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4262
enhrx-5485	chr1	47943933	47943934	47478261	47478262	8894	hg38	N/A	enh42950	N/A	Enhatls6002	enhancer	E3478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042736	0.73052		FOXD2	chr1	47438043	47440691	34923	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5484
enhrx-20353	chr10	61599185	61599186	59839427	59839428	8895	hg38	N/A	enh1224	N/A	Enhatls22419	enhancer	E3479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090249	0.73052		CCDC6	chr10	59788746	59906556	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2788
enhrx-132417	chr5	61504347	61504348	62208520	62208521	8896	hg38	N/A	N/A	N/A	Enhatls141518	enhancer	E3480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039318	0.73052		KIF2A	chr5	62306161	62391025	85700	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2208
enhrx-128671	chr4	146657796	146657797	145736644	145736645	8897	hg38	N/A	enh21850	N/A	Enhatls137573	enhancer	E3481	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.097365	0.73052		C4orf51	chr4	145680145	145732797	2749	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6215
enhrx-115773	chr3	54933479	54933480	54899452	54899453	8898	hg38	N/A	enh20622	N/A	Enhatls123866	enhancer	E3482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049175	0.73102		CACNA2D3	chr3	54122551	55074557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3902
enhrx-45987	chr13	47240312	47240313	46666177	46666178	8899	hg38	N/A	enh15301	N/A	Enhatls49640	enhancer	E3483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0062911	0.73124		LRCH1	chr13	46553167	46753040	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1609
enhrx-137703	chr5	174442226	174442227	175015223	175015224	8900	hg38	N/A	enh97805	N/A	Enhatls147181	enhancer	E3484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015893	0.73124		MSX2	chr5	174724581	174730896	282247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7494
enhrx-160062	chr8	90895046	90895047	89882818	89882819	8901	hg38	N/A	enh25115	N/A	Enhatls170974	enhancer	E3485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091189	0.73124		OSGIN2	chr8	89901848	89927888	14431	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3853
enhrx-20221	chr10	54643840	54643841	52884080	52884081	8902	hg38	N/A	enh1221	N/A	Enhatls22283	enhancer	E3486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10617	0.73124		MBL2	chr10	52765379	52772784	95902	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2656
enhrx-153350	chr7	108222603	108222604	108582159	108582160	8903	hg38	N/A	enh24424	N/A	Enhatls163872	enhancer	E3487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029635	0.73124		DNAJB9	chr7	108569873	108574850	4941	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6162
enhrx-134516	chr5	110885081	110885082	111549383	111549384	8904	hg38	N/A	enh22492	N/A	Enhatls143684	enhancer	E3488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11378	0.73124		STARD4	chr5	111496032	111512590	36758	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-90333	chr2	42001475	42001476	41774335	41774336	8905	hg38	N/A	enh69648	N/A	Enhatls96769	enhancer	E3489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0085742	0.73201		PKDCC	chr2	42048020	42058517	265797	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2259
enhrx-72870	chr17	54849963	54849964	56772602	56772603	8906	hg38	N/A	enh81233	N/A	Enhatls78222	enhancer	E3490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043178	0.73201		C17orf67	chr17	56791912	56833920	17219	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6139
enhrx-49450	chr14	48332829	48332830	47863626	47863627	8907	hg38	N/A	N/A	N/A	Enhatls53351	enhancer	E3491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017327	0.73201		MDGA2	chr14	46840091	47675605	125143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1407
enhrx-44687	chr13	24756987	24756988	24182848	24182849	8908	hg38	N/A	enh15152	N/A	Enhatls48219	enhancer	E3492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17165	0.73201		SPATA13	chr13	23979804	24307074	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	309
enhrx-41708	chr12	104548885	104548886	104155107	104155108	8909	hg38	N/A	enh108545	N/A	Enhatls45073	enhancer	E3493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08737	0.73201		NFYB	chr12	104117085	104138241	14187	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-128531	chr4	144280184	144280185	143359031	143359032	8910	hg38	N/A	enh21839	N/A	Enhatls137437	enhancer	E3494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21263	0.73201		GAB1	chr4	143336875	143474565	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6075
enhrx-125189	chr4	66282757	66282758	65417039	65417040	8911	hg38	N/A	enh83117	N/A	Enhatls133940	enhancer	E3495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14624	0.73263		EPHA5	chr4	65319562	65670495	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2733
enhrx-128156	chr4	127375313	127375314	126454158	126454159	8912	hg38	N/A	N/A	N/A	Enhatls137031	enhancer	E3496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059468	0.73283		FAT4	chr4	125314917	125492932	950629	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5700
enhrx-109315	chr22	27290911	27290912	26894948	26894949	8913	hg38	N/A	enh35007	N/A	Enhatls116983	enhancer	E3497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074311	0.73283		CRYBA4	chr22	26621962	26630669	252449	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1146
enhrx-47609	chr13	110228867	110228868	109576520	109576521	8914	hg38	N/A	enh80718	N/A	Enhatls51412	enhancer	E3498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019537	0.73283		IRS2	chr13	109752694	109786583	174007	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3231
enhrx-174714	chrX	96444880	96444881	97189881	97189882	8915	hg38	N/A	enh98351	N/A	Enhatls186886	enhancer	E3499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0082143	0.73305		DIAPH2	chrX	96684711	97604997	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4431
enhrx-49821	chr14	53822542	53822543	53355824	53355825	8916	hg38	N/A	enh15624	N/A	Enhatls53753	enhancer	E3500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038991	0.73305		DDHD1	chr14	53036744	53153323	199225	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1778
enhrx-17701	chr10	3173490	3173491	3131298	3131299	8917	hg38	N/A	enh94845	N/A	Enhatls19338	enhancer	E3501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0058643	0.73359		PFKP	chr10	3066332	3137718	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	136
enhrx-130571	chr5	7048254	7048255	7048141	7048142	8918	hg38	N/A	N/A	N/A	Enhatls139579	enhancer	E3502	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0065787	0.73359		TENT4A	chr5	6713431	6757044	204322	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	362
enhrx-83362	chr19	29612555	29612556	29121648	29121649	8919	hg38	N/A	N/A	N/A	Enhatls89408	enhancer	E3503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11002	0.7336		UQCRFS1	chr19	29205319	29213151	43504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4332
enhrx-132682	chr5	67889137	67889138	68593310	68593311	8920	hg38	N/A	enh97686	N/A	Enhatls141794	enhancer	E3504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015793	0.73362		PIK3R1	chr5	68215740	68301821	289118	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2473
enhrx-153357	chr7	110659198	110659199	111019142	111019143	8921	hg38	N/A	enh49305	N/A	Enhatls163879	enhancer	E3505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.267	0.734		IMMP2L	chr7	110662643	111562517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6169
enhrx-8521	chr1	106836125	106836126	106293503	106293504	8922	hg38	N/A	N/A	N/A	Enhatls9202	enhancer	E3506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12434	0.73501		PRMT6	chr1	107056673	107059294	762838	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8520
enhrx-160880	chr8	106924978	106924979	105912750	105912751	8923	hg38	N/A	N/A	N/A	Enhatls171833	enhancer	E3507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011141	0.73501		ZFPM2	chr8	105318437	105804539	94389	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4671
enhrx-149048	chr7	34406223	34406224	34366611	34366612	8924	hg38	N/A	N/A	N/A	Enhatls159295	enhancer	E3508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020936	0.73576		BMPER	chr7	33904910	34156427	202917	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1860
enhrx-145909	chr6	147226726	147226727	146905590	146905591	8925	hg38	N/A	enh46233	N/A	Enhatls155957	enhancer	E3509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0045518	0.73576		ADGB	chr6	146598969	146815462	85396	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-114412	chr3	46972677	46972678	46931187	46931188	8926	hg38	N/A	enh7179	N/A	Enhatls122436	enhancer	E3510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012387	0.73576		CCDC12	chr3	46921725	46982010	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-30786	chr11	69257661	69257662	69442893	69442894	8927	hg38	N/A	enh14035	fant39081	Enhatls33470	enhancer	E3511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033177	0.73577		MYEOV	chr11	69294154	69297287	145524	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5455
enhrx-103162	chr20	30298507	30298508	31710704	31710705	8928	hg38	N/A	enh19573	N/A	Enhatls110296	enhancer	E3512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034268	0.73622		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-57727	chr15	74478352	74478353	74186011	74186012	8929	hg38	N/A	N/A	N/A	Enhatls62098	enhancer	E3513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054846	0.73622		STRA6	chr15	74179465	74212267	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4429
enhrx-95055	chr2	131774854	131774855	131017281	131017282	8930	hg38	N/A	enh58938	N/A	Enhatls101778	enhancer	E3514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041853	0.73691		ARHGEF4	chr2	130836913	131047263	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6981
enhrx-39627	chr12	58281918	58281919	57888135	57888136	8931	hg38	N/A	enh2398	fant41987	Enhatls42836	enhancer	E3515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0027263	0.73691		CTDSP2	chr12	57819926	57846729	41126	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4937
enhrx-161562	chr8	125598447	125598448	124586206	124586207	8932	hg38	N/A	N/A	N/A	Enhatls172556	enhancer	E3516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072991	0.73691		MTSS1	chr8	124550783	124728473	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5353
enhrx-73526	chr17	61505862	61505863	63428501	63428502	8933	hg38	N/A	N/A	N/A	Enhatls78923	enhancer	E3517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011714	0.73691		TANC2	chr17	62966234	63427703	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6795
enhrx-123158	chr4	5942309	5942310	5940582	5940583	8934	hg38	N/A	enh7862	N/A	Enhatls131791	enhancer	E3518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052901	0.73691		C4orf50	chr4	5957117	6200555	12960	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	702
enhrx-124060	chr4	37649917	37649918	37648295	37648296	8935	hg38	N/A	enh21430	N/A	Enhatls132761	enhancer	E3519	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035256	0.73691		RELL1	chr4	37590799	37686376	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1604
enhrx-105309	chr20	55863473	55863474	57288417	57288418	8936	hg38	N/A	N/A	N/A	Enhatls112624	enhancer	E3520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064428	0.73691		BMP7	chr20	57168752	57266641	21080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3737
enhrx-91414	chr2	66426192	66426193	66199060	66199061	8937	hg38	N/A	enh96903	N/A	Enhatls97957	enhancer	E3521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.13609	0.73722		MEIS1	chr2	66435124	66573869	231662	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3340
enhrx-36383	chr12	19283996	19283997	19131062	19131063	8938	hg38	N/A	N/A	N/A	Enhatls39458	enhancer	E3522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20636	0.73728		PLEKHA5	chr12	19129732	19376400	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1693
enhrx-42805	chr12	116394640	116394641	115956835	115956836	8939	hg38	N/A	N/A	N/A	Enhatls46225	enhancer	E3523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0089058	0.73844		MED13L	chr12	115958575	116277693	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8115
enhrx-49824	chr14	54779071	54779072	54312353	54312354	8940	hg38	N/A	enh15627	N/A	Enhatls53756	enhancer	E3524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19575	0.73844		CDKN3	chr14	54396978	54420218	81362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1781
enhrx-136940	chr5	154120728	154120729	154741168	154741169	8941	hg38	N/A	enh66104	N/A	Enhatls146335	enhancer	E3525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046379	0.73844		LARP1	chr5	154682985	154817605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6731
enhrx-15739	chr1	222042464	222042465	221869122	221869123	8942	hg38	N/A	enh27555	N/A	Enhatls17282	enhancer	E3526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047823	0.7387		DUSP10	chr1	221701423	221742089	119675	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15738
enhrx-20413	chr10	62822962	62822963	61063204	61063205	8943	hg38	N/A	enh13245	N/A	Enhatls22491	enhancer	E3527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11295	0.73907		RHOBTB1	chr10	60869437	61001440	58508	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2848
enhrx-169509	chr9	137109734	137109735	134217888	134217889	8944	hg38	N/A	enh42336	N/A	N/A	enhancer	E3528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11425	0.73993		WDR5	chr9	134135364	134159968	48972	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6776
enhrx-109151	chr22	25393055	25393056	24997088	24997089	8945	hg38	N/A	enh6793	N/A	Enhatls116800	enhancer	E3529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12421	0.73993		KIAA1671	chr22	24952715	25197448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	982
enhrx-118378	chr3	124752203	124752204	125033359	125033360	8946	hg38	N/A	enh7498	N/A	Enhatls126671	enhancer	E3530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1212	0.73993		HEG1	chr3	124965709	125055997	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6507
enhrx-6301	chr1	61649309	61649310	61183637	61183638	8947	hg38	N/A	enh393	N/A	Enhatls6871	enhancer	E3531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011292	0.74014		NFIA	chr1	60865258	61462788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6300
enhrx-24666	chr10	125137534	125137535	123378018	123378019	8948	hg38	N/A	enh67659	N/A	Enhatls27036	enhancer	E3532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040747	0.74014		BUB3	chr10	123154401	123170467	204583	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7101
enhrx-2833	chr1	24512976	24512977	24186486	24186487	8949	hg38	N/A	enh137	N/A	Enhatls3165	enhancer	E3533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12736	0.74014		IFNLR1	chr1	24154167	24187959	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2832
enhrx-171791	chrX	35160559	35160560	35142442	35142443	8950	hg38	N/A	N/A	N/A	Enhatls183824	enhancer	E3534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0011735	0.74014		FAM47B	chrX	34942795	34944915	172564	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1508
enhrx-76078	chr18	2529087	2529088	2529088	2529089	8951	hg38	N/A	enh4652	N/A	Enhatls81631	enhancer	E3535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1299	0.74028		METTL4	chr18	2537524	2571509	289	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	96
enhrx-131716	chr5	40784327	40784328	40784225	40784226	8952	hg38	N/A	enh45837	N/A	Enhatls140793	enhancer	E3536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1558	0.74028		PRKAA1	chr5	40759388	40798374	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1507
enhrx-34362	chr11	126174465	126174466	126304570	126304571	8953	hg38	N/A	N/A	N/A	Enhatls37268	enhancer	E3537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016685	0.74028		DCPS	chr11	126304059	126350005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9031
enhrx-32371	chr11	95708675	95708676	95975511	95975512	8954	hg38	N/A	N/A	N/A	Enhatls35147	enhancer	E3538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03553	0.74029		MAML2	chr11	95976597	96343195	12	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7040
enhrx-162080	chr8	141663755	141663756	140653656	140653657	8955	hg38	N/A	enh102178	N/A	Enhatls173133	enhancer	E3539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068281	0.7407		PTK2	chr8	140657899	141002110	2144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5871
enhrx-18697	chr10	22264475	22264476	21975546	21975547	8956	hg38	N/A	enh13047	N/A	Enhatls20453	enhancer	E3540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0000274	0.74218		DNAJC1	chr10	21756547	22003730	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1132
enhrx-161248	chr8	120697364	120697365	119685124	119685125	8957	hg38	N/A	enh25243	N/A	Enhatls172220	enhancer	E3541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081465	0.7423		ENPP2	chr8	119557085	119673453	7853	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5039
enhrx-77686	chr18	39627545	39627546	42047581	42047582	8958	hg38	N/A	N/A	N/A	Enhatls83350	enhancer	E3542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012175	0.7423		PIK3C3	chr18	41955233	42087830	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1704
enhrx-106298	chr21	16584033	16584034	15211713	15211714	8959	hg38	N/A	enh19826	N/A	Enhatls113652	enhancer	E3543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07688	0.74231		NRIP1	chr21	14961234	15065815	144711	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-161141	chr8	116624817	116624818	115612590	115612591	8960	hg38	N/A	enh41407	N/A	Enhatls172098	enhancer	E3544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089084	0.74231		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4932
enhrx-131863	chr5	43169085	43169086	43168983	43168984	8961	hg38	N/A	N/A	N/A	Enhatls140944	enhancer	E3545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037686	0.74231		ZNF131	chr5	43068056	43176324	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1654
enhrx-142471	chr6	65214606	65214607	64504713	64504714	8962	hg38	N/A	enh84223	N/A	Enhatls152317	enhancer	E3546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031236	0.74342		EYS	chr6	63719979	65707226	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4059
enhrx-92165	chr2	76056078	76056079	75828952	75828953	8963	hg38	N/A	N/A	N/A	Enhatls98750	enhancer	E3547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00029022	0.74342		GCFC2	chr2	75662704	75710985	102205	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4091
enhrx-88347	chr2	9352628	9352629	9212499	9212500	8964	hg38	N/A	enh33035	N/A	Enhatls94634	enhancer	E3548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096001	0.74343		ASAP2	chr2	9206764	9405683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	273
enhrx-16411	chr1	230346578	230346579	230210832	230210833	8965	hg38	N/A	enh27598	N/A	Enhatls18001	enhancer	E3549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06016	0.74343		GALNT2	chr1	230067237	230282122	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16410
enhrx-32125	chr11	91041388	91041389	91308220	91308221	8966	hg38	N/A	N/A	N/A	Enhatls34895	enhancer	E3550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022818	0.74364		FAT3	chr11	92224817	92896473	913089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6794
enhrx-100606	chr2	233165944	233165945	232301234	232301235	8967	hg38	N/A	N/A	N/A	Enhatls107632	enhancer	E3551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0072285	0.74384		DIS3L2	chr2	231961244	232344350	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12532
enhrx-36825	chr12	26922298	26922299	26769365	26769366	8968	hg38	N/A	enh2237	N/A	Enhatls39916	enhancer	E3552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08654	0.74392		ITPR2	chr12	26335351	26833194	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-92168	chr2	76541932	76541933	76314806	76314807	8969	hg38	N/A	enh60828	N/A	Enhatls98753	enhancer	E3553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27833	0.74392		LRRTM4	chr2	76747684	77593196	430776	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4094
enhrx-27443	chr11	24850679	24850680	24829133	24829134	8970	hg38	N/A	enh79819	N/A	Enhatls29892	enhancer	E3554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090324	0.74392		LUZP2	chr11	24497052	25082638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2112
enhrx-98700	chr2	202619655	202619656	201754932	201754933	8971	hg38	N/A	enh92993	N/A	Enhatls105612	enhancer	E3555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04626	0.74392		ALS2	chr2	201700266	201782112	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10626
enhrx-160683	chr8	102637900	102637901	101625672	101625673	8972	hg38	N/A	enh102155	N/A	Enhatls171631	enhancer	E3556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065521	0.74392		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4474
enhrx-13237	chr1	182150723	182150724	182181588	182181589	8973	hg38	N/A	enh27296	N/A	Enhatls14609	enhancer	E3557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16754	0.74392		ZNF648	chr1	182054569	182061712	117539	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13236
enhrx-58400	chr15	81572309	81572310	81279968	81279969	8974	hg38	N/A	N/A	N/A	Enhatls62829	enhancer	E3558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099373	0.74422		IL16	chr15	81182711	81314058	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5102
enhrx-26785	chr11	13802916	13802917	13781369	13781370	8975	hg38	N/A	enh13795	N/A	Enhatls29206	enhancer	E3559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067395	0.74594		FAR1	chr11	13668667	13732346	41920	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1454
enhrx-102384	chr20	10842471	10842472	10861823	10861824	8976	hg38	N/A	enh34532	N/A	Enhatls109471	enhancer	E3560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012721	0.74597		JAG1	chr20	10637683	10673999	183763	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	812
enhrx-34963	chr12	2879196	2879197	2770030	2770031	8977	hg38	N/A	N/A	N/A	Enhatls37944	enhancer	E3561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082339	0.74862		FKBP4	chr12	2794969	2805423	24666	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	273
enhrx-74228	chr17	70485265	70485266	72489125	72489126	8978	hg38	N/A	enh109785	N/A	Enhatls79688	enhancer	E3562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046188	0.74862		SLC39A11	chr17	72645948	73092712	154454	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7497
enhrx-83608	chr19	34437993	34437994	33947088	33947089	8979	hg38	N/A	enh18036	N/A	Enhatls89666	enhancer	E3563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.080406	0.74862		KCTD15	chr19	33795932	33815763	129138	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4578
enhrx-60721	chr16	4071274	4071275	4021273	4021274	8980	hg38	N/A	enh16510	N/A	Enhatls65290	enhancer	E3564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0093022	0.74877		ADCY9	chr16	3953386	4116442	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1016
enhrx-115441	chr3	52459353	52459354	52425337	52425338	8981	hg38	N/A	N/A	N/A	Enhatls123504	enhancer	E3565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0060084	0.74877		PHF7	chr3	52410659	52423641	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3570
enhrx-136693	chr5	149890226	149890227	150510664	150510665	8982	hg38	N/A	enh22717	N/A	Enhatls146062	enhancer	E3566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058429	0.74877		NDST1	chr5	150485817	150558211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6484
enhrx-168990	chr9	133574102	133574103	130698715	130698716	8983	hg38	N/A	N/A	N/A	Enhatls180897	enhancer	E3567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.061176	0.74877		EXOSC2	chr9	130693764	130704892	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6257
enhrx-110602	chr22	39688977	39688978	39292972	39292973	8984	hg38	hs2508	enh6860	N/A	Enhatls118367	enhancer	E3568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043084	0.74926		RPL3	chr22	39312881	39319623	19154	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2433
enhrx-32808	chr11	107560437	107560438	107689711	107689712	8985	hg38	N/A	enh29106	N/A	Enhatls35609	enhancer	E3569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022274	0.74983		SLN	chr11	107707377	107719693	8749	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7477
enhrx-5976	chr1	54756592	54756593	54290919	54290920	8986	hg38	N/A	enh11865	N/A	Enhatls6516	enhancer	E3570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026753	0.74998		SSBP3	chr1	54225431	54413479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5975
enhrx-77759	chr18	43362803	43362804	45782838	45782839	8987	hg38	N/A	enh32656	N/A	Enhatls83432	enhancer	E3571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019389	0.74998		EPG5	chr18	45800580	45967329	17091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1777
enhrx-97255	chr2	177310937	177310938	176446209	176446210	8988	hg38	N/A	enh5989	N/A	Enhatls104089	enhancer	E3572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078414	0.75072		MTX2	chr2	176269441	176338025	106009	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9181
enhrx-159800	chr8	81279266	81279267	80367031	80367032	8989	hg38	N/A	enh56735	N/A	Enhatls170701	enhancer	E3573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20344	0.75072		ZBTB10	chr8	80485618	80526265	114319	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3591
enhrx-101641	chr20	734746	734747	754102	754103	8990	hg38	N/A	enh53647	N/A	Enhatls108708	enhancer	E3574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09371	0.75082		SLC52A3	chr20	760079	776015	3909	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	69
enhrx-114038	chr3	42788241	42788242	42746749	42746750	8991	hg38	N/A	enh100015	N/A	Enhatls122036	enhancer	E3575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10684	0.75108		CCDC13	chr3	42705755	42773253	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2167
enhrx-158383	chr8	41324294	41324295	41466775	41466776	8992	hg38	N/A	enh98105	N/A	Enhatls169216	enhancer	E3576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010383	0.75108		GOLGA7	chr8	41488199	41511095	8684	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2174
enhrx-59308	chr15	93187938	93187939	92644708	92644709	8993	hg38	N/A	enh69001	N/A	Enhatls63859	enhancer	E3577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053131	0.75108		FAM174B	chr15	92617447	92809798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6010
enhrx-73804	chr17	63538897	63538898	65542779	65542780	8994	hg38	N/A	enh52552	N/A	Enhatls79231	enhancer	E3578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0095044	0.75114		AXIN2	chr17	65528562	65561648	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7073
enhrx-170665	chrX	7077343	7077344	7159302	7159303	8995	hg38	N/A	enh11097	N/A	Enhatls182630	enhancer	E3579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20345	0.75114		STS	chrX	7147290	7453758	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	382
enhrx-92397	chr2	85812295	85812296	85585172	85585173	8996	hg38	N/A	enh18704	N/A	Enhatls98994	enhancer	E3580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037185	0.75114		VAMP5	chr2	85584430	85593406	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4323
enhrx-72714	chr17	48862699	48862700	50785338	50785339	8997	hg38	N/A	enh17223	N/A	Enhatls78064	enhancer	E3581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051319	0.75116		ANKRD40CL	chr17	50761029	50767557	10028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5983
enhrx-137695	chr5	173919142	173919143	174492139	174492140	8998	hg38	N/A	enh84043	N/A	Enhatls147171	enhancer	E3582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042799	0.75191		MSX2	chr5	174724581	174730896	228192	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-34624	chr11	134040359	134040360	134170464	134170465	8999	hg38	N/A	N/A	N/A	Enhatls37570	enhancer	E3583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053052	0.75191		NCAPD3	chr11	134150112	134225504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9293
enhrx-106615	chr21	30896070	30896071	29523749	29523750	9000	hg38	N/A	N/A	N/A	Enhatls113999	enhancer	E3584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0095083	0.75191		BACH1	chr21	29194070	29630751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	498
enhrx-59393	chr15	96501890	96501891	95958661	95958662	9001	hg38	N/A	enh99297	N/A	Enhatls63955	enhancer	E3585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037688	0.75272		NR2F2	chr15	96325937	96340263	365312	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6095
enhrx-83582	chr19	33839757	33839758	33348851	33348852	9002	hg38	N/A	enh18030	N/A	Enhatls89636	enhancer	E3586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0086302	0.75272		CEBPG	chr19	33373708	33382686	23171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4552
enhrx-49012	chr14	34250665	34250666	33781459	33781460	9003	hg38	N/A	enh3080	N/A	Enhatls52911	enhancer	E3587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053822	0.75272		NPAS3	chr14	32934395	33804176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	969
enhrx-94919	chr2	129816735	129816736	129059162	129059163	9004	hg38	N/A	enh33647	fant8526	Enhatls101631	enhancer	E3588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10727	0.75272		HS6ST1	chr2	128265479	128318868	740227	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6845
enhrx-47529	chr13	103654745	103654746	103002395	103002396	9005	hg38	N/A	enh3010	N/A	Enhatls51319	enhancer	E3589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074007	0.75272		SLC10A2	chr13	103043997	103066417	40562	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3151
enhrx-45987	chr13	47234076	47234077	46659941	46659942	9006	hg38	N/A	enh15301	N/A	Enhatls49640	enhancer	E3590	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064461	0.75293		LRCH1	chr13	46553167	46753040	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1609
enhrx-138988	chr6	13726018	13726019	13725786	13725787	9007	hg38	N/A	enh23045	N/A	Enhatls148588	enhancer	E3591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10389	0.75293		RANBP9	chr6	13621497	13711835	9392	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	576
enhrx-157592	chr8	26323237	26323238	26465721	26465722	9008	hg38	N/A	enh10193	N/A	Enhatls168358	enhancer	E3592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1692	0.75293		BNIP3L	chr8	26383053	26505636	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1383
enhrx-27437	chr11	24364280	24364281	24342734	24342735	9009	hg38	N/A	N/A	N/A	Enhatls29886	enhancer	E3593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058173	0.7534		LUZP2	chr11	24497052	25082638	107794	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2106
enhrx-172196	chrX	44933725	44933726	45074480	45074481	9010	hg38	N/A	N/A	N/A	Enhatls184239	enhancer	E3594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045223	0.7534		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1913
enhrx-160850	chr8	105365487	105365488	104353259	104353260	9011	hg38	N/A	enh114986	N/A	Enhatls171800	enhancer	E3595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14809	0.75368		DCSTAMP	chr8	104339795	104356689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4641
enhrx-53644	chr15	25854691	25854692	25609544	25609545	9012	hg38	N/A	N/A	N/A	Enhatls57799	enhancer	E3596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0076584	0.75395		ATP10A	chr15	25677272	25865172	54912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	346
enhrx-161599	chr8	126082523	126082524	125070281	125070282	9013	hg38	N/A	enh41536	N/A	Enhatls172594	enhancer	E3597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16885	0.75395		WASHC5	chr8	125024259	125091792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5390
enhrx-1210	chr1	11018921	11018922	10958864	10958865	9014	hg38	N/A	enh63991	N/A	Enhatls1312	enhancer	E3598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11684	0.75435		C1orf127	chr1	10946472	10982076	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1209
enhrx-164053	chr9	34072603	34072604	34072605	34072606	9015	hg38	N/A	enh25540	N/A	Enhatls175171	enhancer	E3599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12934	0.75485		DCAF12	chr9	34086386	34127399	9782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1320
enhrx-137333	chr5	167513512	167513513	168086507	168086508	9016	hg38	N/A	enh46015	N/A	Enhatls146761	enhancer	E3600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.086088	0.75485		TENM2	chr5	166979028	168264157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7124
enhrx-103157	chr20	30195251	30195252	31607448	31607449	9017	hg38	N/A	enh19572	fant58352	Enhatls110290	enhancer	E3601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088915	0.75485		ID1	chr20	31605282	31606515	650	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1585
enhrx-4843	chr1	43403626	43403627	42937955	42937956	9018	hg38	N/A	enh296	N/A	Enhatls5312	enhancer	E3602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12953	0.75485		SLC2A1	chr1	42925352	42958868	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4842
enhrx-66578	chr16	89648695	89648696	89582287	89582288	9019	hg38	N/A	N/A	N/A	Enhatls71485	enhancer	E3603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042943	0.75485		CPNE7	chr16	89575757	89597246	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6873
enhrx-57938	chr15	75865541	75865542	75573200	75573201	9020	hg38	N/A	enh3727	N/A	Enhatls62331	enhancer	E3604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040436	0.75485		PTPN9	chr15	75463250	75579315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4640
enhrx-69146	chr17	19151619	19151620	19248306	19248307	9021	hg38	N/A	enh17049	N/A	Enhatls74181	enhancer	E3605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0079318	0.75485		EPN2	chr17	19215614	19336715	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2415
enhrx-163979	chr9	33415773	33415774	33415775	33415776	9022	hg38	N/A	enh25537	fant32152	Enhatls175092	enhancer	E3606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10964	0.75485		AQP7	chr9	33383178	33402680	12822	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1246
enhrx-102507	chr20	15995285	15995286	16014640	16014641	9023	hg38	N/A	N/A	N/A	Enhatls109605	enhancer	E3607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020114	0.75485		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	935
enhrx-124052	chr4	37456307	37456308	37454685	37454686	9024	hg38	N/A	N/A	N/A	Enhatls132752	enhancer	E3608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12563	0.75485		C4orf19	chr4	37453924	37623495	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1596
enhrx-134380	chr5	105430046	105430047	106094345	106094346	9025	hg38	N/A	enh83911	N/A	Enhatls143550	enhancer	E3609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02844	0.75485		EFNA5	chr5	107376893	107670937	1280420	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4171
enhrx-37715	chr12	46867694	46867695	46473911	46473912	9026	hg38	N/A	enh14677	fant41542	Enhatls40840	enhancer	E3610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18882	0.75492		SLC38A2	chr12	46358187	46372773	100933	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3025
enhrx-4242	chr1	36902640	36902641	36437039	36437040	9027	hg38	N/A	enh11742	N/A	Enhatls4677	enhancer	E3611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10727	0.75518		OSCP1	chr1	36415826	36450451	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4241
enhrx-118347	chr3	124505877	124505878	124787030	124787031	9028	hg38	N/A	enh20879	N/A	Enhatls126635	enhancer	E3612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035349	0.75518		ITGB5	chr3	124761947	124901418	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6476
enhrx-17339	chr1	245281618	245281619	245118316	245118317	9029	hg38	N/A	enh101175	N/A	Enhatls18964	enhancer	E3613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077381	0.75518		EFCAB2	chr1	244969681	245121981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17338
enhrx-102702	chr20	19232789	19232790	19252145	19252146	9030	hg38	N/A	enh19527	N/A	Enhatls109810	enhancer	E3614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046193	0.75531		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1130
enhrx-15599	chr1	218845113	218845114	218671771	218671772	9031	hg38	N/A	enh27514	N/A	Enhatls17137	enhancer	E3615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01248	0.75531		TGFB2	chr1	218345335	218444619	216014	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15598
enhrx-172258	chrX	46778039	46778040	46918604	46918605	9032	hg38	N/A	enh93889	N/A	N/A	enhancer	E3616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063903	0.75531		JADE3	chrX	46912275	47061242	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1975
enhrx-123098	chr4	5367635	5367636	5365908	5365909	9033	hg38	N/A	enh36317	N/A	Enhatls131723	enhancer	E3617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.036041	0.75571		STK32B	chr4	5051479	5500994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	642
enhrx-171074	chrX	16394328	16394329	16376205	16376206	9034	hg38	N/A	N/A	N/A	Enhatls183061	enhancer	E3618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054111	0.75571		MAGEB17	chrX	16167480	16171464	151709	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	791
enhrx-58337	chr15	80582013	80582014	80289671	80289672	9035	hg38	N/A	enh52125	N/A	Enhatls62759	enhancer	E3619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080822	0.75571		CTXND1	chr15	80195480	80252213	35636	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5039
enhrx-132637	chr5	65993830	65993831	66698002	66698003	9036	hg38	N/A	enh37920	N/A	Enhatls141742	enhancer	E3620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094653	0.75571		MAST4	chr5	66596379	67169593	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2428
enhrx-26304	chr11	7666758	7666759	7645527	7645528	9037	hg38	N/A	N/A	N/A	Enhatls28670	enhancer	E3621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039795	0.75576		PPFIBP2	chr11	7513297	7657078	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	973
enhrx-90598	chr2	46636325	46636326	46409186	46409187	9038	hg38	N/A	enh18526	N/A	Enhatls97064	enhancer	E3622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16558	0.75653		EPAS1	chr2	46296607	46386697	15570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2524
enhrx-129393	chr4	166342559	166342560	165421407	165421408	9039	hg38	N/A	N/A	N/A	Enhatls138316	enhancer	E3623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17862	0.75696		CPE	chr4	165361193	165498547	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6937
enhrx-16681	chr1	235054079	235054080	234918332	234918333	9040	hg38	N/A	enh12798	N/A	Enhatls18291	enhancer	E3624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053434	0.75696		TOMM20	chr1	235109340	235128837	182423	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16680
enhrx-2750	chr1	24054149	24054150	23727659	23727660	9041	hg38	N/A	enh60103	N/A	Enhatls3063	enhancer	E3625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060366	0.757		ELOA	chr1	23743470	23762059	10958	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2749
enhrx-121107	chr3	179544202	179544203	179826414	179826415	9042	hg38	N/A	N/A	N/A	Enhatls129595	enhancer	E3626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073658	0.75706		PEX5L	chr3	179794957	180037053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9236
enhrx-42828	chr12	116457383	116457384	116019578	116019579	9043	hg38	N/A	N/A	N/A	Enhatls46248	enhancer	E3627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1615	0.75798		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8138
enhrx-118317	chr3	124271355	124271356	124552508	124552509	9044	hg38	N/A	enh20873	N/A	Enhatls126598	enhancer	E3628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10189	0.75798		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6446
enhrx-151789	chr7	93932569	93932570	94303257	94303258	9045	hg38	N/A	enh24335	N/A	Enhatls162258	enhancer	E3629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018945	0.75798		COL1A2	chr7	94394894	94431227	82992	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4601
enhrx-9639	chr1	120333600	120333601	119790977	119790978	9046	hg38	N/A	enh12221	N/A	Enhatls10412	enhancer	E3630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.004773	0.75817		REG4	chr1	119794016	119811580	145	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9638
enhrx-146572	chr6	159882463	159882464	159461431	159461432	9047	hg38	N/A	enh9522	fant24909	Enhatls156682	enhancer	E3631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072332	0.75817		FNDC1	chr6	159169399	159272108	189192	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8160
enhrx-54685	chr15	41069119	41069120	40776921	40776922	9048	hg38	N/A	N/A	N/A	Enhatls58881	enhancer	E3632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0701	0.75834		DNAJC17	chr15	40765160	40807478	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1387
enhrx-36302	chr12	16064629	16064630	15911695	15911696	9049	hg38	N/A	N/A	N/A	Enhatls39372	enhancer	E3633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028711	0.75883		DERA	chr12	15911328	16037381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1612
enhrx-173569	chrX	69745737	69745738	70525887	70525888	9050	hg38	N/A	enh85714	N/A	Enhatls185742	enhancer	E3634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0076656	0.75892		TEX11	chrX	70528939	70908711	915	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3286
enhrx-13443	chr1	184602152	184602153	184633018	184633019	9051	hg38	N/A	enh12470	N/A	Enhatls14847	enhancer	E3635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012761	0.75925		C1orf21	chr1	184387028	184629019	8	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13442
enhrx-88789	chr2	19172974	19172975	18991699	18991700	9052	hg38	N/A	enh18308	N/A	Enhatls95125	enhancer	E3636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013309	0.75925		OSR1	chr2	19351484	19358623	357315	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	715
enhrx-46556	chr13	69286221	69286222	68712089	68712090	9053	hg38	N/A	enh30417	N/A	Enhatls50271	enhancer	E3637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041397	0.75925		KLHL1	chr13	69700593	70108493	983991	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2178
enhrx-29345	chr11	61369221	61369222	61601749	61601750	9054	hg38	N/A	enh13959	N/A	Enhatls31870	enhancer	E3638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071205	0.75925		SYT7	chr11	61513713	61581148	15831	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4014
enhrx-133766	chr5	87441578	87441579	88145761	88145762	9055	hg38	N/A	enh88942	N/A	Enhatls142903	enhancer	E3639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.078511	0.76004		TMEM161B	chr5	88189632	88268857	41875	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3557
enhrx-69405	chr17	25858046	25858047	27531020	27531021	9056	hg38	N/A	enh17064	fant52197	Enhatls74507	enhancer	E3640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0046485	0.76034		KSR1	chr17	27456447	27626438	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2674
enhrx-9017	chr1	111960581	111960582	111417959	111417960	9057	hg38	N/A	enh12142	fant2768	Enhatls9731	enhancer	E3641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027544	0.76034		OVGP1	chr1	111414318	111427735	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9016
enhrx-157849	chr8	29464981	29464982	29607465	29607466	9058	hg38	N/A	enh10216	N/A	Enhatls168631	enhancer	E3642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062105	0.76034		DUSP4	chr8	29333063	29350684	253086	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-73344	chr17	59434200	59434201	61356839	61356840	9059	hg38	N/A	N/A	N/A	Enhatls78727	enhancer	E3643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071812	0.76034		BCAS3	chr17	60677452	61392838	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6613
enhrx-77205	chr18	24325470	24325471	26745506	26745507	9060	hg38	N/A	enh81334	N/A	Enhatls82857	enhancer	E3644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0068945	0.76035		KCTD1	chr18	26454909	26657401	81241	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1223
enhrx-21512	chr10	80692823	80692824	78933066	78933067	9061	hg38	N/A	enh1376	N/A	Enhatls23668	enhancer	E3645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084088	0.76035		ZMIZ1	chr10	79068965	79316519	128455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-148836	chr7	30687880	30687881	30648264	30648265	9062	hg38	N/A	N/A	N/A	Enhatls159069	enhancer	E3646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047912	0.76035		CRHR2	chr7	30651941	30700103	8	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1648
enhrx-41708	chr12	104571849	104571850	104178071	104178072	9063	hg38	N/A	enh14939	fant42918	Enhatls45073	enhancer	E3647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1343	0.76035		TXNRD1	chr12	104215778	104350307	37511	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7018
enhrx-34158	chr11	124712338	124712339	124842442	124842443	9064	hg38	N/A	N/A	N/A	Enhatls37063	enhancer	E3648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0053477	0.76035		ROBO3	chr11	124865431	124881471	5028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8827
enhrx-80705	chr19	7717268	7717269	7652382	7652383	9065	hg38	N/A	enh17894	N/A	Enhatls86569	enhancer	E3649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047371	0.76035		STXBP2	chr19	7637104	7647873	2327	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1675
enhrx-119534	chr3	139734111	139734112	140015269	140015270	9066	hg38	N/A	N/A	N/A	Enhatls127905	enhancer	E3650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036733	0.76035		CLSTN2	chr3	139935184	140577397	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7663
enhrx-91276	chr2	62521075	62521076	62293940	62293941	9067	hg38	N/A	enh18592	N/A	Enhatls97795	enhancer	E3651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0015204	0.76035		B3GNT2	chr2	62196114	62224731	67516	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3202
enhrx-40953	chr12	94564592	94564593	94170816	94170817	9068	hg38	N/A	enh14908	N/A	Enhatls44268	enhancer	E3652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076719	0.76035		PLXNC1	chr12	94148576	94307675	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6263
enhrx-133681	chr5	82618515	82618516	83322696	83322697	9069	hg38	N/A	enh114002	N/A	Enhatls142812	enhancer	E3653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012079	0.76035		XRCC4	chr5	83077497	83353787	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3472
enhrx-81415	chr19	11007712	11007713	10897036	10897037	9070	hg38	N/A	enh5003	N/A	Enhatls87289	enhancer	E3654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0061622	0.76035		CARM1	chr19	10871552	10923075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2385
enhrx-68583	chr17	14623112	14623113	14719795	14719796	9071	hg38	N/A	enh96737	N/A	Enhatls73599	enhancer	E3655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060107	0.76059		HS3ST3B1	chr17	14301080	14349404	368265	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1852
enhrx-52414	chr14	95707784	95707785	95241447	95241448	9072	hg38	N/A	enh3410	N/A	Enhatls56524	enhancer	E3656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12437	0.76059		CLMN	chr14	95181939	95319908	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4371
enhrx-102767	chr20	20422074	20422075	20441430	20441431	9073	hg38	N/A	enh53727	N/A	Enhatls109885	enhancer	E3657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035777	0.76092		RALGAPA2	chr20	20389529	20712644	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1195
enhrx-45092	chr13	31055543	31055544	30481406	30481407	9074	hg38	N/A	enh51498	N/A	Enhatls48655	enhancer	E3658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15735	0.7616		HMGB1	chr13	30456703	30617597	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	714
enhrx-103157	chr20	30195699	30195700	31607896	31607897	9075	hg38	N/A	enh19572	N/A	Enhatls110290	enhancer	E3659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050336	0.7616		ID1	chr20	31605282	31606515	1027	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1585
enhrx-172161	chrX	44082603	44082604	44223357	44223358	9076	hg38	N/A	enh85659	N/A	Enhatls184204	enhancer	E3660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06815	0.76178		EFHC2	chrX	44147871	44343672	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1878
enhrx-161255	chr8	120780072	120780073	119767832	119767833	9077	hg38	N/A	N/A	N/A	Enhatls172228	enhancer	E3661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026992	0.76178		TAF2	chr8	119730773	119832855	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5046
enhrx-161365	chr8	122163344	122163345	121151104	121151105	9078	hg38	N/A	enh25255	fant30716	Enhatls172343	enhancer	E3662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015557	0.76217		SNTB1	chr8	120535744	120813273	337670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5156
enhrx-31904	chr11	86025825	86025826	86314783	86314784	9079	hg38	N/A	enh96242	N/A	Enhatls34661	enhancer	E3663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095192	0.76217		HIKESHI	chr11	86302210	86345943	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6573
enhrx-19091	chr10	29413929	29413930	29125000	29125001	9080	hg38	N/A	enh96056	N/A	Enhatls20864	enhancer	E3664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0015417	0.76217		LYZL1	chr10	29289060	29311232	159535	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-134978	chr5	124393047	124393048	125057354	125057355	9081	hg38	N/A	enh38347	N/A	Enhatls144187	enhancer	E3665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085726	0.7622		ZNF608	chr5	124636914	124748807	293431	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4769
enhrx-13075	chr1	179835985	179835986	179866850	179866851	9082	hg38	N/A	N/A	N/A	Enhatls14441	enhancer	E3666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096308	0.7622		TOR1AIP2	chr1	179839966	179877803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13074
enhrx-102598	chr20	17702912	17702913	17722267	17722268	9083	hg38	N/A	enh88590	N/A	Enhatls109701	enhancer	E3667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15052	0.7622		BANF2	chr20	17693671	17735871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1026
enhrx-8272	chr1	100564778	100564779	100099222	100099223	9084	hg38	N/A	enh27024	N/A	Enhatls8956	enhancer	E3668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062456	0.76275		SASS6	chr1	100083569	100132930	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8271
enhrx-72869	chr17	54620830	54620831	56543469	56543470	9085	hg38	N/A	enh44459	N/A	Enhatls78221	enhancer	E3669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026807	0.76275		ANKFN1	chr17	55882300	56517016	26162	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6138
enhrx-78867	chr18	72782885	72782886	75070929	75070930	9086	hg38	N/A	enh17813	N/A	Enhatls84610	enhancer	E3670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.094898	0.76275		ZNF407	chr18	74597869	75065671	3749	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2885
enhrx-120006	chr3	150063017	150063018	150345230	150345231	9087	hg38	N/A	enh21028	N/A	Enhatls128397	enhancer	E3671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13766	0.76275		TSC22D2	chr3	150408297	150466422	54093	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8135
enhrx-139027	chr6	15949788	15949789	15949557	15949558	9088	hg38	N/A	enh23076	N/A	Enhatls148638	enhancer	E3672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023942	0.76275		MYLIP	chr6	16129085	16148248	177125	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	615
enhrx-106615	chr21	30806176	30806177	29433856	29433857	9089	hg38	N/A	enh19882	N/A	Enhatls113999	enhancer	E3673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11076	0.76275		BACH1	chr21	29194070	29630751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	498
enhrx-49848	chr14	55132034	55132035	54665316	54665317	9090	hg38	N/A	enh3199	N/A	Enhatls53782	enhancer	E3674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11063	0.76275		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1805
enhrx-63825	chr16	53315972	53315973	53282060	53282061	9091	hg38	N/A	enh109719	N/A	Enhatls68510	enhancer	E3675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040353	0.76275		CHD9	chr16	53054990	53329150	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4120
enhrx-34547	chr11	130380476	130380477	130510581	130510582	9092	hg38	N/A	enh14405	N/A	Enhatls37482	enhancer	E3676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038097	0.76275		ADAMTS15	chr11	130448644	130476645	30391	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9216
enhrx-26580	chr11	10373778	10373779	10352231	10352232	9093	hg38	hs2289	enh13754	fant37903	Enhatls28975	enhancer	E3677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12885	0.76275		AMPD3	chr11	10317670	10507579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1249
enhrx-62252	chr16	22792615	22792616	22781294	22781295	9094	hg38	N/A	N/A	N/A	Enhatls66878	enhancer	E3678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10427	0.7628		HS3ST2	chr16	22814161	22916338	31677	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2547
enhrx-90557	chr2	45347823	45347824	45120684	45120685	9095	hg38	N/A	enh33279	N/A	Enhatls97011	enhancer	E3679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090114	0.76284		SIX2	chr2	45005181	45009452	107692	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2483
enhrx-86018	chr19	48013615	48013616	47510358	47510359	9096	hg38	N/A	enh44672	N/A	Enhatls92192	enhancer	E3680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19925	0.76284		NAPA	chr19	47487636	47515063	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6988
enhrx-lit80	chr2	166809892	166809893	165953382	165953383	9097	hg38					enhancer	E3681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0073413	0.76305							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-82494	chr19	17131314	17131315	17020504	17020505	9098	hg38	N/A	enh17962	N/A	Enhatls88461	enhancer	E3682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025143	0.76305		CPAMD8	chr19	16892950	17026810	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3464
enhrx-165492	chr9	81155043	81155044	78540127	78540128	9099	hg38	N/A	enh73695	N/A	Enhatls177100	enhancer	E3683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16218	0.7634		PSAT1	chr9	78297124	78330093	207716	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2759
enhrx-111703	chr22	50732420	50732421	50293991	50293992	9100	hg38	N/A	N/A	N/A	Enhatls119543	enhancer	E3684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030634	0.7634		PLXNB2	chr22	50274978	50307646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3534
enhrx-157560	chr8	25523142	25523143	25665626	25665627	9101	hg38	N/A	N/A	N/A	Enhatls168327	enhancer	E3685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020068	0.7634		CDCA2	chr8	25459198	25507911	121181	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1351
enhrx-49848	chr14	55044783	55044784	54578065	54578066	9102	hg38	N/A	enh3198	N/A	Enhatls53782	enhancer	E3686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051166	0.7634		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1805
enhrx-2061	chr1	17754991	17754992	17428495	17428496	9103	hg38	N/A	N/A	N/A	Enhatls2309	enhancer	E3687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058919	0.7634		RCC2	chr1	17406759	17439677	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2060
enhrx-106954	chr21	35226383	35226384	33854079	33854080	9104	hg38	N/A	N/A	N/A	Enhatls114351	enhancer	E3688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13436	0.7634		ITSN1	chr21	33642399	33899861	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	837
enhrx-94915	chr2	129131954	129131955	128374380	128374381	9105	hg38	N/A	enh18865	fant8509	Enhatls101626	enhancer	E3689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016324	0.7634		HS6ST1	chr2	128265479	128318868	55111	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6841
enhrx-152921	chr7	103047468	103047469	103407021	103407022	9106	hg38	N/A	N/A	N/A	Enhatls163426	enhancer	E3690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024006	0.7634		SLC26A5	chr7	103352729	103446207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5733
enhrx-63904	chr16	54209295	54209296	54175383	54175384	9107	hg38	N/A	enh16673	N/A	Enhatls68587	enhancer	E3691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036626	0.7634		FTO	chr16	53701691	54153448	16631	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4199
enhrx-33306	chr11	115280583	115280584	115409865	115409866	9108	hg38	N/A	enh51004	N/A	Enhatls36141	enhancer	E3692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0049817	0.7635		CADM1	chr11	115169235	115504957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7975
enhrx-33309	chr11	115834994	115834995	115964276	115964277	9109	hg38	N/A	enh29175	N/A	Enhatls36145	enhancer	E3693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034425	0.7635		CADM1	chr11	115169235	115504957	456210	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7978
enhrx-59157	chr15	91137878	91137879	90594646	90594647	9110	hg38	N/A	enh3794	N/A	Enhatls63703	enhancer	E3694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033746	0.7635		CRTC3	chr15	90529922	90645345	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5859
enhrx-121844	chr3	189101584	189101585	189383795	189383796	9111	hg38	N/A	N/A	N/A	Enhatls130397	enhancer	E3695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024378	0.7635		TPRG1	chr3	188947213	189325304	49203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9973
enhrx-117119	chr3	102043462	102043463	102324618	102324619	9112	hg38	N/A	N/A	N/A	Enhatls125337	enhancer	E3696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089899	0.7635		ZPLD1	chr3	102099243	102479841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5248
enhrx-68583	chr17	14374529	14374530	14471212	14471213	9113	hg38	N/A	enh17016	N/A	Enhatls73599	enhancer	E3697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031321	0.7635		HS3ST3B1	chr17	14301080	14349404	119643	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1852
enhrx-133013	chr5	72326979	72326980	73031152	73031153	9114	hg38	N/A	enh22344	N/A	Enhatls142130	enhancer	E3698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17936	0.7635		FCHO2	chr5	72956040	73090522	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2804
enhrx-106386	chr21	21895638	21895639	20523325	20523326	9115	hg38	N/A	N/A	N/A	Enhatls113749	enhancer	E3699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020078	0.7635		NCAM2	chr21	20998408	21543329	405956	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	269
enhrx-143122	chr6	83587099	83587100	82877380	82877381	9116	hg38	N/A	enh84271	N/A	Enhatls152983	enhancer	E3700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085838	0.7635		UBE3D	chr6	82892389	83065841	12771	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4710
enhrx-47799	chr13	113377423	113377424	112723109	112723110	9117	hg38	N/A	enh15512	fant45350	Enhatls51622	enhancer	E3701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064966	0.7635		ATP11A	chr13	112690037	112887168	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3421
enhrx-9639	chr1	120322749	120322750	119780126	119780127	9118	hg38	N/A	enh12221	N/A	Enhatls10412	enhancer	E3702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031346	0.7635		REG4	chr1	119794016	119811580	145	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9638
enhrx-15200	chr1	210558154	210558155	210384810	210384811	9119	hg38	N/A	enh27456	N/A	Enhatls16722	enhancer	E3703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12946	0.7635		HHAT	chr1	210328251	210676296	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15199
enhrx-7751	chr1	91557931	91557932	91092374	91092375	9120	hg38	N/A	enh26955	N/A	Enhatls8386	enhancer	E3704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016489	0.7635		ZNF644	chr1	90915297	91022272	67557	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7750
enhrx-160926	chr8	109237627	109237628	108225398	108225399	9121	hg38	N/A	enh78556	N/A	Enhatls171880	enhancer	E3705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034983	0.76441		EIF3E	chr8	108162786	108443496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4717
enhrx-121876	chr3	189948039	189948040	190230250	190230251	9122	hg38	N/A	enh21217	N/A	Enhatls130428	enhancer	E3706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20671	0.76442		CLDN1	chr3	190305706	190322446	64181	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10005
enhrx-151501	chr7	88355298	88355299	88725984	88725985	9123	hg38	N/A	enh98031	N/A	Enhatls161965	enhancer	E3707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11511	0.76442		ZNF804B	chr7	88759699	89338528	31779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4313
enhrx-133682	chr5	82714396	82714397	83418577	83418578	9124	hg38	N/A	N/A	N/A	Enhatls142813	enhancer	E3708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19183	0.76442		VCAN	chr5	83471673	83582303	23108	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3473
enhrx-58840	chr15	87830521	87830522	87287290	87287291	9125	hg38	N/A	enh31574	N/A	Enhatls63364	enhancer	E3709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044437	0.76442		AGBL1	chr15	86079870	87029052	256163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5542
enhrx-55102	chr15	42897802	42897803	42605604	42605605	9126	hg38	N/A	enh16086	N/A	Enhatls59319	enhancer	E3710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012939	0.76442		STARD9	chr15	42575605	42720998	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1804
enhrx-139189	chr6	20117969	20117970	20117738	20117739	9127	hg38	N/A	N/A	N/A	Enhatls148801	enhancer	E3711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096283	0.76442		MBOAT1	chr6	20099683	20212469	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	777
enhrx-121209	chr3	182345020	182345021	182627232	182627233	9128	hg38	N/A	enh54520	N/A	Enhatls129702	enhancer	E3712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23872	0.76442		ATP11B	chr3	182793502	182921629	157444	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9338
enhrx-90845	chr2	54271291	54271292	54044154	54044155	9129	hg38	N/A	enh33336	N/A	Enhatls97332	enhancer	E3713	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046248	0.76442		ACYP2	chr2	53970837	54305300	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2771
enhrx-92999	chr2	97345974	97345975	96680237	96680238	9130	hg38	N/A	enh96920	N/A	Enhatls99605	enhancer	E3714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026053	0.76442		FER1L5	chr2	96642763	96704887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4925
enhrx-21243	chr10	75361470	75361471	73601712	73601713	9131	hg38	N/A	enh50497	N/A	Enhatls23368	enhancer	E3715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033712	0.76442		USP54	chr10	73497537	73626117	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3678
enhrx-145833	chr6	146162967	146162968	145841831	145841832	9132	hg38	N/A	enh9414	N/A	Enhatls155880	enhancer	E3716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0050378	0.76442		SHPRH	chr6	145864244	145964389	17866	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7421
enhrx-79660	chr19	2507261	2507262	2507263	2507264	9133	hg38	N/A	enh4958	fant55854	Enhatls85463	enhancer	E3717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019808	0.7656		GNG7	chr19	2511218	2702694	3759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	630
enhrx-159751	chr8	78156976	78156977	77244740	77244741	9134	hg38	N/A	N/A	N/A	Enhatls170645	enhancer	E3718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025033	0.7656		PEX2	chr8	76980257	77001044	237076	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3542
enhrx-14490	chr1	203392037	203392038	203422909	203422910	9135	hg38	N/A	N/A	N/A	Enhatls15947	enhancer	E3719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084997	0.7656		PRELP	chr1	203475805	203491352	52089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14489
enhrx-123895	chr4	25725244	25725245	25723622	25723623	9136	hg38	N/A	enh21411	N/A	Enhatls132584	enhancer	E3720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013743	0.7656		SEL1L3	chr4	25747432	25863760	17080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1439
enhrx-6648	chr1	66918011	66918012	66452328	66452329	9137	hg38	N/A	enh405	N/A	Enhatls7243	enhancer	E3721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058475	0.7656		PDE4B	chr1	65792513	66374579	71163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6647
enhrx-137697	chr5	174004234	174004235	174577231	174577232	9138	hg38	N/A	N/A	N/A	Enhatls147175	enhancer	E3722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030779	0.7656		MSX2	chr5	174724581	174730896	145040	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-16861	chr1	236670853	236670854	236507553	236507554	9139	hg38	N/A	enh12815	N/A	Enhatls18462	enhancer	E3723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035326	0.7662		LGALS8	chr1	236517999	236552981	8405	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16860
enhrx-77410	chr18	30031764	30031765	32451801	32451802	9140	hg38	N/A	enh112536	N/A	Enhatls83066	enhancer	E3724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0060975	0.7662		GAREM1	chr18	32124876	32470882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1428
enhrx-65075	chr16	69384763	69384764	69350860	69350861	9141	hg38	N/A	N/A	N/A	Enhatls69840	enhancer	E3725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098656	0.7662		TMED6	chr16	69343249	69351786	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5370
enhrx-13822	chr1	196644181	196644182	196675051	196675052	9142	hg38	N/A	N/A	N/A	Enhatls15247	enhancer	E3726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018751	0.7662		CFH	chr1	196651753	196752476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13821
enhrx-125262	chr4	68577826	68577827	67712108	67712109	9143	hg38	N/A	enh21559	N/A	Enhatls134014	enhancer	E3727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26477	0.7662		UBA6	chr4	67612651	67701155	8913	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2806
enhrx-93608	chr2	103238280	103238281	102621821	102621822	9144	hg38	N/A	N/A	N/A	Enhatls100250	enhancer	E3728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048409	0.76671		SLC9A2	chr2	102619552	102711355	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5534
enhrx-27851	chr11	34190573	34190574	34169026	34169027	9145	hg38	N/A	N/A	N/A	Enhatls30308	enhancer	E3729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0031545	0.76673		ABTB2	chr11	34150986	34358010	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2520
enhrx-72941	chr17	56004913	56004914	57927552	57927553	9146	hg38	N/A	enh4496	N/A	Enhatls78310	enhancer	E3730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013958	0.76742		CUEDC1	chr17	57861242	57955412	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6210
enhrx-47663	chr13	111100794	111100795	110448447	110448448	9147	hg38	N/A	N/A	N/A	Enhatls51472	enhancer	E3731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13551	0.76742		COL4A2	chr13	110305811	110513209	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3285
enhrx-116793	chr3	95912028	95912029	96193184	96193185	9148	hg38	N/A	enh97314	N/A	Enhatls124982	enhancer	E3732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.102	0.76742		EPHA6	chr3	96814580	97761532	619390	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4922
enhrx-66147	chr16	84574068	84574069	84540462	84540463	9149	hg38	N/A	enh16851	N/A	Enhatls71003	enhancer	E3733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11569	0.76742		MEAK7	chr16	84476354	84554033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6442
enhrx-128404	chr4	140843004	140843005	139921850	139921851	9150	hg38	N/A	enh8227	N/A	Enhatls137303	enhancer	E3734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.081861	0.76782		MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5948
enhrx-19606	chr10	44732449	44732450	44237001	44237002	9151	hg38	N/A	enh13175	N/A	Enhatls21411	enhancer	E3735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053319	0.76811		CXCL12	chr10	44370164	44385097	122298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2041
enhrx-33258	chr11	114050148	114050149	114179426	114179427	9152	hg38	N/A	enh47523	fant39935	Enhatls36091	enhancer	E3736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026943	0.76811		ZBTB16	chr11	114059040	114256765	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7927
enhrx-160842	chr8	105218999	105219000	104206771	104206772	9153	hg38	N/A	N/A	N/A	Enhatls171793	enhancer	E3737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0088007	0.76825		RIMS2	chr8	103500609	104254430	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4633
enhrx-46664	chr13	75928985	75928986	75354849	75354850	9154	hg38	N/A	enh64735	N/A	Enhatls50383	enhancer	E3738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033855	0.76837		TBC1D4	chr13	75283502	75482169	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2286
enhrx-125976	chr4	77562655	77562656	76641502	76641503	9155	hg38	N/A	N/A	N/A	Enhatls134772	enhancer	E3739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076377	0.76848		SHROOM3	chr4	76435228	76783253	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3520
enhrx-64071	chr16	56852049	56852050	56818137	56818138	9156	hg38	N/A	enh4045	N/A	Enhatls68770	enhancer	E3740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087128	0.76848		NUP93	chr16	56730117	56850286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4366
enhrx-17671	chr10	1573590	1573591	1531395	1531396	9157	hg38	N/A	N/A	N/A	Enhatls19308	enhancer	E3741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073654	0.76848		ADARB2	chr10	1177312	1737525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	106
enhrx-137697	chr5	174134408	174134409	174707405	174707406	9158	hg38	N/A	N/A	N/A	Enhatls147175	enhancer	E3742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057754	0.76947		MSX2	chr5	174724581	174730896	5015	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-156714	chr8	11570882	11570883	11713373	11713374	9159	hg38	N/A	enh10168	N/A	Enhatls167414	enhancer	E3743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14438	0.76947		GATA4	chr8	11676958	11760002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-143956	chr6	105962358	105962359	105514483	105514484	9160	hg38	N/A	enh72433	N/A	Enhatls153832	enhancer	E3744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15501	0.76947		PREP	chr6	105273217	105454062	59137	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5544
enhrx-109318	chr22	28125600	28125601	27729612	27729613	9161	hg38	N/A	enh20106	N/A	Enhatls116986	enhancer	E3745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089169	0.76947		MN1	chr22	27748276	27801756	15280	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1149
enhrx-133937	chr5	92943165	92943166	93607459	93607460	9162	hg38	N/A	enh22432	N/A	Enhatls143090	enhancer	E3746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067409	0.76947		ARB2A	chr5	93617724	94111676	9846	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3728
enhrx-126300	chr4	84183961	84183962	83262808	83262809	9163	hg38	N/A	N/A	N/A	Enhatls135113	enhancer	E3747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036899	0.76981		COQ2	chr4	83263823	83284914	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3844
enhrx-131700	chr5	40552518	40552519	40552416	40552417	9164	hg38	N/A	enh37769	N/A	Enhatls140778	enhancer	E3748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083735	0.76981		TTC33	chr5	40512332	40755963	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1491
enhrx-135457	chr5	132830676	132830677	133494984	133494985	9165	hg38	N/A	N/A	N/A	Enhatls144702	enhancer	E3749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012974	0.77001		FSTL4	chr5	133196454	133612541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5248
enhrx-54394	chr15	37511700	37511701	37219499	37219500	9166	hg38	N/A	enh88157	N/A	Enhatls58585	enhancer	E3750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084459	0.77001		MEIS2	chr15	36889203	37101299	112986	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1096
enhrx-166943	chr9	109916817	109916818	107154536	107154537	9167	hg38	N/A	enh46824	N/A	Enhatls178680	enhancer	E3751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090065	0.77001		RAD23B	chr9	107283136	107332192	127524	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4210
enhrx-128680	chr4	146783304	146783305	145862152	145862153	9168	hg38	N/A	enh8250	N/A	Enhatls137582	enhancer	E3752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1715	0.77001		ZNF827	chr4	145757626	145938823	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6224
enhrx-4727	chr1	41902557	41902558	41436886	41436887	9169	hg38	N/A	N/A	N/A	Enhatls5187	enhancer	E3753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15256	0.77001		EDN2	chr1	41478774	41484683	37993	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4726
enhrx-57386	chr15	69887175	69887176	69594836	69594837	9170	hg38	N/A	enh44145	N/A	Enhatls61747	enhancer	E3754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05056	0.77001		RPLP1	chr15	69452813	69456205	132197	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4088
enhrx-167269	chr9	114679658	114679659	111917378	111917379	9171	hg38	N/A	N/A	N/A	Enhatls179016	enhancer	E3755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030328	0.77061		UGCG	chr9	111896813	111935369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4536
enhrx-170614	chrX	4749095	4749096	4831054	4831055	9172	hg38	N/A	enh85540	N/A	Enhatls182572	enhancer	E3756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084379	0.77062		NLGN4X	chrX	5890031	6228867	1056788	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	331
enhrx-29340	chr11	61305930	61305931	61538458	61538459	9173	hg38	N/A	enh79905	N/A	Enhatls31863	enhancer	E3757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059103	0.77075		SYT7	chr11	61513713	61581148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4009
enhrx-109318	chr22	27912986	27912987	27517025	27517026	9174	hg38	N/A	enh35019	N/A	Enhatls116986	enhancer	E3758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053808	0.77106		MN1	chr22	27748276	27801756	226824	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1149
enhrx-45826	chr13	44793232	44793233	44219096	44219097	9175	hg38	N/A	enh30300	N/A	Enhatls49459	enhancer	E3759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039931	0.77106			chr13	44143149	44161257	55133	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1448
enhrx-116243	chr3	64317393	64317394	64331717	64331718	9176	hg38	N/A	enh20662	fant12357	Enhatls124387	enhancer	E3760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023721	0.77106		PRICKLE2	chr3	64092235	64445407	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4372
enhrx-124270	chr4	40048138	40048139	40046518	40046519	9177	hg38	N/A	enh54669	N/A	Enhatls132986	enhancer	E3761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027462	0.77106		N4BP2	chr4	40056849	40158252	8235	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1814
enhrx-166925	chr9	109518215	109518216	106755934	106755935	9178	hg38	N/A	enh61639	N/A	Enhatls178661	enhancer	E3762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010084	0.77175		ZNF462	chr9	106863165	107013634	101992	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4192
enhrx-59436	chr15	99277829	99277830	98734600	98734601	9179	hg38	N/A	N/A	N/A	Enhatls64002	enhancer	E3763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083118	0.77175		IGF1R	chr15	98648538	98964530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6138
enhrx-69501	chr17	26802520	26802521	28475502	28475503	9180	hg38	N/A	N/A	N/A	Enhatls74606	enhancer	E3764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098985	0.77225		SLC13A2	chr17	28473292	28497781	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2770
enhrx-28896	chr11	57540080	57540081	57772608	57772609	9181	hg38	N/A	enh13938	N/A	Enhatls31418	enhancer	E3765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.098907	0.77225		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-116500	chr3	73095484	73095485	73046333	73046334	9182	hg38	N/A	N/A	N/A	Enhatls124679	enhancer	E3766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077349	0.77225		PPP4R2	chr3	72996810	73069198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4629
enhrx-170715	chrX	9235738	9235739	9267698	9267699	9183	hg38	N/A	N/A	N/A	Enhatls182680	enhancer	E3767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010236	0.77225		FAM9B	chrX	9024231	9295682	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	432
enhrx-59555	chr15	101391019	101391020	100850814	100850815	9184	hg38	N/A	enh16474	N/A	Enhatls64126	enhancer	E3768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15705	0.77225		ALDH1A3	chr15	100877713	100916626	25924	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6257
enhrx-17726	chr10	4312390	4312391	4270198	4270199	9185	hg38	N/A	enh27737	N/A	Enhatls19369	enhancer	E3769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10491	0.77225		KLF6	chr10	3775995	3785281	473033	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	161
enhrx-161660	chr8	130444315	130444316	129432069	129432070	9186	hg38	N/A	enh85265	N/A	Enhatls172677	enhancer	E3770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075255	0.77225		GSDMC	chr8	129748195	129786624	313687	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5451
enhrx-27981	chr11	36660276	36660277	36638726	36638727	9187	hg38	N/A	enh96193	N/A	Enhatls30451	enhancer	E3771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015386	0.77225		IFTAP	chr11	36594368	36659291	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2650
enhrx-91381	chr2	65025144	65025145	64798010	64798011	9188	hg38	N/A	enh5590	N/A	Enhatls97914	enhancer	E3772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05335	0.77225		SERTAD2	chr2	64631620	64653913	119836	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3307
enhrx-3563	chr1	31731710	31731711	31258863	31258864	9189	hg38	N/A	N/A	N/A	Enhatls3943	enhancer	E3773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010682	0.77225		SNRNP40	chr1	31259567	31296788	5	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3562
enhrx-124100	chr4	38567306	38567307	38565685	38565686	9190	hg38	N/A	enh45660	fant15579	Enhatls132806	enhancer	E3774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23537	0.77225		KLF3	chr4	38664196	38701517	98414	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1644
enhrx-95955	chr2	155619347	155619348	154762835	154762836	9191	hg38	N/A	N/A	N/A	Enhatls102720	enhancer	E3775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080152	0.77225		KCNJ3	chr2	154697854	154858354	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7881
enhrx-9795	chr1	145631250	145631251	145803826	145803827	9192	hg38	N/A	enh605	N/A	Enhatls10797	enhancer	E3776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00068358	0.77225		RNF115	chr1	145738867	145824095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9794
enhrx-22714	chr10	99087831	99087832	97328074	97328075	9193	hg38	N/A	enh67593	N/A	Enhatls24966	enhancer	E3777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01201	0.77225		FRAT2	chr10	97332496	97334729	1499	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5149
enhrx-152693	chr7	101606345	101606346	101963065	101963066	9194	hg38	N/A	enh100712	N/A	Enhatls163185	enhancer	E3778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085393	0.77225		CUX1	chr7	101815903	102283958	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-97259	chr2	178035048	178035049	177170320	177170321	9195	hg38	N/A	enh5999	N/A	Enhatls104094	enhancer	E3779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25146	0.77225		HNRNPA3	chr2	177212723	177223959	41180	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9185
enhrx-52432	chr14	95990241	95990242	95523904	95523905	9196	hg38	N/A	enh15901	N/A	Enhatls56543	enhancer	E3780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038361	0.7723		SYNE3	chr14	95407265	95516650	6914	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4389
enhrx-100344	chr2	230015212	230015213	229150496	229150497	9197	hg38	N/A	N/A	N/A	Enhatls107353	enhancer	E3781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034685	0.77236		PID1	chr2	229023972	229271287	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12270
enhrx-149356	chr7	40366867	40366868	40327268	40327269	9198	hg38	N/A	enh40096	N/A	Enhatls159628	enhancer	E3782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22201	0.77237		SUGCT	chr7	40135004	40860763	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2168
enhrx-173421	chrX	66865025	66865026	67645183	67645184	9199	hg38	N/A	N/A	N/A	Enhatls185588	enhancer	E3783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018484	0.77321		AR	chrX	67544020	67730619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3138
enhrx-107006	chr21	37301320	37301321	35929022	35929023	9200	hg38	N/A	N/A	N/A	Enhatls114418	enhancer	E3784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11148	0.77321		RUNX1	chr21	34787800	36004667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	889
enhrx-127817	chr4	119667564	119667565	118746409	118746410	9201	hg38	N/A	N/A	N/A	Enhatls136686	enhancer	E3785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066162	0.77362		SEC24D	chr4	118722822	118836614	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5361
enhrx-33018	chr11	111273423	111273424	111402698	111402699	9202	hg38	N/A	N/A	N/A	Enhatls35827	enhancer	E3786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15513	0.77362		POU2AF1	chr11	111352254	111449981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7687
enhrx-31824	chr11	83980211	83980212	84269168	84269169	9203	hg38	N/A	N/A	N/A	Enhatls34579	enhancer	E3787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12014	0.77362		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6493
enhrx-151127	chr7	78923086	78923087	79293770	79293771	9204	hg38	N/A	enh40294	fant26866	Enhatls161563	enhancer	E3788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15147	0.77369		MAGI2	chr7	78017054	79453667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3939
enhrx-65824	chr16	77613406	77613407	77579509	77579510	9205	hg38	N/A	enh52328	N/A	Enhatls70634	enhancer	E3789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1002	0.77393		ADAMTS18	chr16	77247812	77435034	138315	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6119
enhrx-172172	chrX	44318905	44318906	44459659	44459660	9206	hg38	N/A	N/A	N/A	Enhatls184215	enhancer	E3790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056761	0.77428		FUNDC1	chrX	44523638	44542859	62700	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1889
enhrx-23960	chr10	115687226	115687227	113927467	113927468	9207	hg38	N/A	enh13524	N/A	Enhatls26304	enhancer	E3791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03194	0.77428		NHLRC2	chr10	113854660	113917194	8233	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6395
enhrx-66323	chr16	87823782	87823783	87790176	87790177	9208	hg38	N/A	enh4179	fant51383	Enhatls71216	enhancer	E3792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1846	0.77428		KLHDC4	chr16	87698147	87765992	24001	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6618
enhrx-68413	chr17	10660607	10660608	10757290	10757291	9209	hg38	N/A	enh44382	N/A	Enhatls73420	enhancer	E3793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20319	0.77428		TMEM220	chr17	10699014	10730023	25341	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1682
enhrx-134737	chr5	115999099	115999100	116663403	116663404	9210	hg38	N/A	N/A	N/A	Enhatls143928	enhancer	E3794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11324	0.77474		SEMA6A	chr5	116443554	116574823	84097	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4528
enhrx-8872	chr1	110503249	110503250	109960627	109960628	9211	hg38	N/A	enh12130	N/A	Enhatls9573	enhancer	E3795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11466	0.77474		AHCYL1	chr1	109984764	110023742	21052	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8871
enhrx-156591	chr8	8128082	8128083	8270560	8270561	9212	hg38	N/A	enh10137	N/A	Enhatls167276	enhancer	E3796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079548	0.77474		PRAG1	chr8	8317735	8386439	40983	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	382
enhrx-48902	chr14	31559972	31559973	31090766	31090767	9213	hg38	N/A	enh3051	fant45679	Enhatls52794	enhancer	E3797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019589	0.77552		AP4S1	chr14	31025105	31130996	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	859
enhrx-69959	chr17	29982223	29982224	31655204	31655205	9214	hg38	N/A	enh17098	N/A	Enhatls75097	enhancer	E3798	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093525	0.77552		RAB11FIP4	chr17	31391674	31538211	116975	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3228
enhrx-156678	chr8	10818399	10818400	10960889	10960890	9215	hg38	N/A	N/A	N/A	Enhatls167370	enhancer	E3799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013755	0.77552		XKR6	chr8	10896044	11201833	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	469
enhrx-88306	chr2	8666060	8666061	8525930	8525931	9216	hg38	N/A	enh18235	N/A	Enhatls94581	enhancer	E3800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042149	0.77552		ID2	chr2	8678844	8684461	150420	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	232
enhrx-49454	chr14	49994980	49994981	49528262	49528263	9217	hg38	N/A	enh96513	N/A	Enhatls53355	enhancer	E3801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026317	0.77552		RPS29	chr14	49570983	49598690	40687	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1411
enhrx-23821	chr10	114047018	114047019	112287260	112287261	9218	hg38	N/A	N/A	N/A	Enhatls26142	enhancer	E3802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12107	0.77552		TECTB	chr10	112283399	112305038	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6256
enhrx-15881	chr1	224391552	224391553	224203850	224203851	9219	hg38	N/A	enh12716	N/A	Enhatls17435	enhancer	E3803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087903	0.77552		DEGS1	chr1	224175755	224193441	551	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15880
enhrx-62503	chr16	27254502	27254503	27243181	27243182	9220	hg38	N/A	enh16613	fant50314	Enhatls67148	enhancer	E3804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077475	0.77553		NSMCE1	chr16	27224993	27268772	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2798
enhrx-110795	chr22	41405619	41405620	41009615	41009616	9221	hg38	N/A	enh20220	N/A	Enhatls118565	enhancer	E3805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023548	0.77553		RBX1	chr22	40951377	40973309	20653	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2626
enhrx-107432	chr21	43124553	43124554	41704393	41704394	9222	hg38	N/A	enh19995	N/A	Enhatls114873	enhancer	E3806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072913	0.77553		RIPK4	chr21	41739368	41767089	27939	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1315
enhrx-29345	chr11	61394389	61394390	61626917	61626918	9223	hg38	N/A	enh13959	fant38745	Enhatls31874	enhancer	E3807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14828	0.77553		SYT7	chr11	61513713	61581148	45644	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4014
enhrx-95055	chr2	131762406	131762407	131004833	131004834	9224	hg38	N/A	N/A	N/A	Enhatls101778	enhancer	E3808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021899	0.77553		ARHGEF4	chr2	130836913	131047263	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6981
enhrx-113259	chr3	31487400	31487401	31445908	31445909	9225	hg38	N/A	enh20467	N/A	Enhatls121185	enhancer	E3809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.052901	0.77553		STT3B	chr3	31532924	31637616	82142	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1388
enhrx-8210	chr1	100101033	100101034	99635477	99635478	9226	hg38	N/A	enh111473	N/A	Enhatls8895	enhancer	E3810	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051421	0.77553		PALMD	chr1	99646112	99694535	7874	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8209
enhrx-4525	chr1	40119039	40119040	39653367	39653368	9227	hg38	N/A	enh64028	N/A	Enhatls4974	enhancer	E3811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021236	0.77553		NT5C1A	chr1	39651228	39672107	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4524
enhrx-69283	chr17	20195319	20195320	20292006	20292007	9228	hg38	N/A	enh96738	N/A	Enhatls74328	enhancer	E3812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1116	0.77557		SPECC1	chr17	20008864	20319026	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2552
enhrx-100926	chr2	236314812	236314813	235406168	235406169	9229	hg38	N/A	enh95582	N/A	Enhatls107963	enhancer	E3813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11076	0.77557		AGAP1	chr2	235494042	236131793	85372	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12852
enhrx-4569	chr1	40446343	40446344	39980671	39980672	9230	hg38	N/A	enh265	N/A	Enhatls5026	enhancer	E3814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11945	0.77611		MFSD2A	chr1	39955111	39969968	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4568
enhrx-66075	chr16	84130736	84130737	84097131	84097132	9231	hg38	N/A	enh81155	N/A	Enhatls70927	enhancer	E3815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010516	0.77611		MBTPS1	chr16	84053762	84116942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6370
enhrx-90588	chr2	46319672	46319673	46092533	46092534	9232	hg38	N/A	enh18511	N/A	Enhatls97048	enhancer	E3816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10441	0.77623		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2514
enhrx-26658	chr11	11476501	11476502	11454954	11454955	9233	hg38	N/A	enh13770	N/A	Enhatls29067	enhancer	E3817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17966	0.77623		GALNT18	chr11	11270876	11622005	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1327
enhrx-153250	chr7	107591199	107591200	107950754	107950755	9234	hg38	N/A	enh66444	N/A	Enhatls163768	enhancer	E3818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13943	0.77623		LAMB1	chr7	107923798	108003213	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6062
enhrx-61162	chr16	11427848	11427849	11333991	11333992	9235	hg38	N/A	enh3885	N/A	Enhatls65745	enhancer	E3819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.085156	0.77644		RMI2	chr16	11249648	11381662	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1457
enhrx-90578	chr2	45853937	45853938	45626798	45626799	9236	hg38	N/A	enh88444	N/A	Enhatls97037	enhancer	E3820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13386	0.77644		SRBD1	chr2	45388679	45611267	13380	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2504
enhrx-165663	chr9	87404563	87404564	84789648	84789649	9237	hg38	N/A	enh25657	N/A	Enhatls177291	enhancer	E3821	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12868	0.77644		NTRK2	chr9	84668374	85095751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2930
enhrx-41950	chr12	108575598	108575599	108181821	108181822	9238	hg38	N/A	N/A	N/A	Enhatls45320	enhancer	E3822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.008314	0.77644		WSCD2	chr12	108129287	108250537	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7260
enhrx-94414	chr2	118247251	118247252	117489675	117489676	9239	hg38	N/A	enh96933	N/A	Enhatls101106	enhancer	E3823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065892	0.77644		DDX18	chr2	117814690	117832377	322912	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6340
enhrx-115771	chr3	54925881	54925882	54891854	54891855	9240	hg38	N/A	N/A	N/A	Enhatls123864	enhancer	E3824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10357	0.77644		CACNA2D3	chr3	54122551	55074557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3900
enhrx-30566	chr11	67235712	67235713	67468241	67468242	9241	hg38	N/A	N/A	N/A	Enhatls33205	enhancer	E3825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078953	0.77644		TMEM134	chr11	67461709	67469251	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5235
enhrx-30566	chr11	67235712	67235713	67468241	67468242	9242	hg38	N/A	N/A	N/A	Enhatls33205	enhancer	E3825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078953	0.77644		AIP	chr11	67468173	67491154	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5235
enhrx-29198	chr11	60710836	60710837	60943364	60943365	9243	hg38	N/A	enh96213	N/A	Enhatls31717	enhancer	E3826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0021348	0.7768		SLC15A3	chr11	60937059	60952653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3867
enhrx-163939	chr9	33229563	33229564	33229565	33229566	9244	hg38	N/A	enh25535	fant32144	Enhatls175051	enhancer	E3827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1174	0.7768		SPINK4	chr9	33218364	33248567	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1206
enhrx-156712	chr8	11508771	11508772	11651262	11651263	9245	hg38	N/A	N/A	N/A	Enhatls167412	enhancer	E3828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088442	0.77757		GATA4	chr8	11676958	11760002	17383	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	503
enhrx-167566	chr9	117307536	117307537	114545256	114545257	9246	hg38	N/A	N/A	N/A	Enhatls179334	enhancer	E3829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.047204	0.77757		WHRN	chr9	114402079	114505473	36803	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4833
enhrx-45092	chr13	31060768	31060769	30486631	30486632	9247	hg38	N/A	enh15200	N/A	Enhatls48655	enhancer	E3830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099375	0.77757		HMGB1	chr13	30456703	30617597	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	714
enhrx-111116	chr22	43510175	43510176	43114169	43114170	9248	hg38	N/A	enh61007	N/A	Enhatls118903	enhancer	E3831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050248	0.77757		BIK	chr22	43110749	43129712	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2947
enhrx-154412	chr7	133118776	133118777	133434022	133434023	9249	hg38	N/A	enh40613	N/A	Enhatls165014	enhancer	E3832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029867	0.77757		EXOC4	chr7	133253072	134065761	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7224
enhrx-144414	chr6	113787958	113787959	113466756	113466757	9250	hg38	N/A	enh23534	N/A	Enhatls154343	enhancer	E3833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071746	0.77757		MARCKS	chr6	113857344	113863475	390112	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-116460	chr3	71258123	71258124	71208972	71208973	9251	hg38	N/A	enh54193	N/A	Enhatls124629	enhancer	E3834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079581	0.77757		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4589
enhrx-171973	chrX	40377528	40377529	40518276	40518277	9252	hg38	N/A	enh73926	N/A	Enhatls184017	enhancer	E3835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034483	0.77799		ATP6AP2	chrX	40579371	40606848	56219	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1690
enhrx-167894	chr9	124850186	124850187	122087907	122087908	9253	hg38	N/A	enh46866	N/A	Enhatls179707	enhancer	E3836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02933	0.77824		TTLL11	chr9	121815673	122093606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5161
enhrx-136883	chr5	152292668	152292669	152913108	152913109	9254	hg38	N/A	N/A	N/A	Enhatls146280	enhancer	E3837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19318	0.77824		NMUR2	chr5	152391545	152405279	455037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6674
enhrx-158025	chr8	35719385	35719386	35861867	35861868	9255	hg38	N/A	enh56640	N/A	Enhatls168833	enhancer	E3838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.12825	0.77824		UNC5D	chr8	35235474	35796550	62518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1816
enhrx-26894	chr11	16176391	16176392	16154845	16154846	9256	hg38	N/A	enh50733	N/A	Enhatls29318	enhancer	E3839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10883	0.77824		SOX6	chr11	15966448	16476388	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1563
enhrx-127092	chr4	102793761	102793762	101872604	101872605	9257	hg38	N/A	N/A	N/A	Enhatls135933	enhancer	E3840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075592	0.77824		BANK1	chr4	101419960	102074812	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4636
enhrx-134581	chr5	112294348	112294349	112958651	112958652	9258	hg38	N/A	enh22502	N/A	Enhatls143759	enhancer	E3841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013507	0.77824		DCP2	chr5	112976701	113022195	5144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4372
enhrx-159281	chr8	67374983	67374984	66462748	66462749	9259	hg38	N/A	enh25056	N/A	Enhatls170144	enhancer	E3842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093199	0.77824		ADHFE1	chr8	66432491	66468907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3072
enhrx-165522	chr9	83658964	83658965	81044049	81044050	9260	hg38	N/A	N/A	N/A	Enhatls177133	enhancer	E3843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053308	0.77824		TLE1	chr9	81583682	81689547	514833	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-24271	chr10	120385214	120385215	118625702	118625703	9261	hg38	N/A	enh43428	N/A	Enhatls26624	enhancer	E3844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029959	0.77824		PRLHR	chr10	118589996	118595648	23746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6706
enhrx-90398	chr2	43206905	43206906	42979765	42979766	9262	hg38	N/A	enh18489	fant6818	Enhatls96840	enhancer	E3845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055016	0.77824		HAAO	chr2	42767088	42792583	187049	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2324
enhrx-72940	chr17	55978898	55978899	57901537	57901538	9263	hg38	N/A	enh17245	fant53117	Enhatls78309	enhancer	E3846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19428	0.77824		CUEDC1	chr17	57861242	57955412	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6209
enhrx-42835	chr12	116887301	116887302	116449496	116449497	9264	hg38	N/A	enh47627	N/A	Enhatls46256	enhancer	E3847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25166	0.77832		MAP1LC3B2	chr12	116559380	116576606	108162	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-61826	chr16	19763146	19763147	19751824	19751825	9265	hg38	N/A	enh16596	N/A	Enhatls66439	enhancer	E3848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0046784	0.77839		IQCK	chr16	19716455	19858467	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2121
enhrx-49330	chr14	44624324	44624325	44155121	44155122	9266	hg38	N/A	N/A	N/A	Enhatls53229	enhancer	E3849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01821	0.77938		FSCB	chr14	44504148	44507283	337567	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1287
enhrx-129925	chr4	185118228	185118229	184197075	184197076	9267	hg38	N/A	enh97600	N/A	Enhatls138886	enhancer	E3850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037711	0.77938		ENPP6	chr4	184088705	184221230	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7469
enhrx-37642	chr12	45699795	45699796	45306012	45306013	9268	hg38	N/A	enh14667	N/A	Enhatls40758	enhancer	E3851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11951	0.77938		ANO6	chr12	45216019	45440404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2952
enhrx-123290	chr4	7807437	7807438	7805710	7805711	9269	hg38	N/A	enh21348	N/A	Enhatls131934	enhancer	E3852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13825	0.77938		AFAP1	chr4	7758713	7939926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	834
enhrx-19091	chr10	29404407	29404408	29115478	29115479	9270	hg38	N/A	N/A	N/A	Enhatls20864	enhancer	E3853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015572	0.77938		LYZL1	chr10	29289060	29311232	171605	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-78325	chr18	55756130	55756131	58088898	58088899	9271	hg38	N/A	enh58829	N/A	Enhatls84027	enhancer	E3854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.062558	0.77938		NEDD4L	chr18	58044225	58401540	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2343
enhrx-100976	chr2	237733637	237733638	236824994	236824995	9272	hg38	N/A	enh53630	N/A	Enhatls108013	enhancer	E3855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26922	0.77997		ACKR3	chr2	236567786	236582354	238789	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12902
enhrx-134078	chr5	95095555	95095556	95759851	95759852	9273	hg38	N/A	enh22440	N/A	Enhatls143236	enhancer	E3856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22316	0.78008		GLRX	chr5	95751318	95822726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3869
enhrx-134078	chr5	95095555	95095556	95759851	95759852	9274	hg38	N/A	enh22440	N/A	Enhatls143236	enhancer	E3856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22316	0.78008		RHOBTB3	chr5	95730871	95824383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3869
enhrx-972	chr1	8849846	8849847	8789787	8789788	9275	hg38	N/A	enh11476	N/A	Enhatls1048	enhancer	E3857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12496	0.7802		RERE	chr1	8352396	8848921	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	971
enhrx-107032	chr21	37575244	37575245	36202946	36202947	9276	hg38	N/A	enh19940	N/A	Enhatls114448	enhancer	E3858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063511	0.7802		DOP1B	chr21	36156823	36294274	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	915
enhrx-99836	chr2	219991349	219991350	219126627	219126628	9277	hg38	N/A	N/A	N/A	Enhatls106816	enhancer	E3859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12855	0.78046		NHEJ1	chr2	219069356	219160816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11762
enhrx-53667	chr15	26372118	26372119	26126971	26126972	9278	hg38	N/A	enh68855	N/A	Enhatls57825	enhancer	E3860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10736	0.78046		ATP10A	chr15	25677272	25865172	261202	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	369
enhrx-88931	chr2	23772212	23772213	23549342	23549343	9279	hg38	N/A	enh18340	N/A	Enhatls95270	enhancer	E3861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0085207	0.78046		KLHL29	chr2	23385178	23708606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	857
enhrx-33256	chr11	113888573	113888574	114017851	114017852	9280	hg38	N/A	enh101279	N/A	Enhatls36088	enhancer	E3862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065695	0.78046		HTR3A	chr11	113975074	113990313	26871	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7925
enhrx-131146	chr5	32144928	32144929	32144822	32144823	9281	hg38	N/A	enh65993	N/A	Enhatls140177	enhancer	E3863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060622	0.78046		GOLPH3	chr5	32124715	32174319	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	937
enhrx-37156	chr12	32573240	32573241	32420306	32420307	9282	hg38	N/A	enh68096	N/A	Enhatls40264	enhancer	E3864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039139	0.78046		FGD4	chr12	32399557	32646050	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2466
enhrx-102874	chr20	22661119	22661120	22680481	22680482	9283	hg38	N/A	N/A	N/A	Enhatls109997	enhancer	E3865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049485	0.78116		FOXA2	chr20	22580997	22585455	80503	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1302
enhrx-172247	chrX	46672094	46672095	46812659	46812660	9284	hg38	N/A	enh85682	N/A	Enhatls184297	enhancer	E3866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077266	0.78142		RP2	chrX	46837042	46882358	22283	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1964
enhrx-88346	chr2	9245521	9245522	9105392	9105393	9285	hg38	N/A	enh18241	N/A	Enhatls94633	enhancer	E3867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0015647	0.78142		MBOAT2	chr2	8852689	9003684	90013	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	272
enhrx-148254	chr7	18569059	18569060	18529436	18529437	9286	hg38	N/A	enh9625	N/A	Enhatls158432	enhancer	E3868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10716	0.78142		HDAC9	chr7	18086948	19002416	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1066
enhrx-2593	chr1	22237169	22237170	21910676	21910677	9287	hg38	N/A	enh11593	N/A	Enhatls2880	enhancer	E3869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025133	0.78142		HSPG2	chr1	21822243	21937310	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2592
enhrx-53660	chr15	26129149	26129150	25884002	25884003	9288	hg38	N/A	enh31199	N/A	Enhatls57817	enhancer	E3870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018843	0.78232		ATP10A	chr15	25677272	25865172	15447	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	362
enhrx-8912	chr1	110659702	110659703	110117080	110117081	9289	hg38	N/A	enh555	N/A	Enhatls9612	enhancer	E3871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10886	0.78276		UBL4B	chr1	110112442	110113947	2	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8911
enhrx-2665	chr1	23153485	23153486	22826992	22826993	9290	hg38	N/A	enh122	N/A	Enhatls2952	enhancer	E3872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14958	0.78276		EPHB2	chr1	22710838	22921500	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2664
enhrx-110129	chr22	36759645	36759646	36363600	36363601	9291	hg38	N/A	enh6844	N/A	Enhatls117853	enhancer	E3873	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0056519	0.78276		MYH9	chr22	36281279	36388001	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1960
enhrx-128404	chr4	140941327	140941328	140020173	140020174	9292	hg38	N/A	enh8231	N/A	Enhatls137303	enhancer	E3874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018799	0.78326		MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5948
enhrx-57459	chr15	71629823	71629824	71337484	71337485	9293	hg38	N/A	enh16303	N/A	Enhatls61823	enhancer	E3875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011801	0.78326		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4161
enhrx-42831	chr12	116537611	116537612	116099806	116099807	9294	hg38	N/A	N/A	N/A	Enhatls46251	enhancer	E3876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077787	0.78326		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8141
enhrx-45088	chr13	30969881	30969882	30395744	30395745	9295	hg38	N/A	enh2751	N/A	Enhatls48648	enhancer	E3877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037811	0.7835		UBE2L5	chr13	30422487	30429758	15913	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	710
enhrx-61737	chr16	19135220	19135221	19123898	19123899	9296	hg38	N/A	enh81095	N/A	Enhatls66348	enhancer	E3878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13704	0.78354		ITPRIPL2	chr16	19113963	19121629	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-166532	chr9	100920757	100920758	98158475	98158476	9297	hg38	N/A	N/A	N/A	Enhatls178242	enhancer	E3879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.028029	0.78377		CORO2A	chr9	98120974	98192637	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3799
enhrx-48340	chr14	22025739	22025740	21557608	21557609	9298	hg38	N/A	enh88082	fant45493	Enhatls52184	enhancer	E3880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03033	0.78377		OR10G3	chr14	21568519	21580076	10633	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	297
enhrx-63909	chr16	54574899	54574900	54540987	54540988	9299	hg38	N/A	enh96686	N/A	Enhatls68591	enhancer	E3881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20926	0.78413		IRX3	chr16	54283303	54286787	252127	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4204
enhrx-42830	chr12	116497901	116497902	116060096	116060097	9300	hg38	N/A	enh30005	N/A	Enhatls46250	enhancer	E3882	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047537	0.78474		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8140
enhrx-33467	chr11	117758832	117758833	117888117	117888118	9301	hg38	N/A	enh14309	N/A	Enhatls36324	enhancer	E3883	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23057	0.78474		FXYD6	chr11	117836975	117877486	8581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8136
enhrx-78423	chr18	57217326	57217327	59550094	59550095	9302	hg38	N/A	enh65155	N/A	Enhatls84140	enhancer	E3884	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021441	0.78474		CCBE1	chr18	59430938	59697662	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2441
enhrx-134977	chr5	124178131	124178132	124842438	124842439	9303	hg38	N/A	enh90318	fant19706	Enhatls144185	enhancer	E3885	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050399	0.78474		ZNF608	chr5	124636914	124748807	93632	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4768
enhrx-15085	chr1	208110241	208110242	207936896	207936897	9304	hg38	N/A	enh12607	N/A	Enhatls16598	enhancer	E3886	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.002236	0.78474		CD34	chr1	207880971	207911402	24739	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15084
enhrx-29448	chr11	62091394	62091395	62323922	62323923	9305	hg38	N/A	enh1811	N/A	Enhatls31997	enhancer	E3887	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14413	0.78474		ASRGL1	chr11	62337447	62393412	8405	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4117
enhrx-110685	chr22	40413739	40413740	40017735	40017736	9306	hg38	N/A	N/A	N/A	Enhatls118451	enhancer	E3888	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01473	0.78493		FAM83F	chr22	39994953	40043534	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2516
enhrx-19227	chr10	32384251	32384252	32095323	32095324	9307	hg38	N/A	enh79532	N/A	Enhatls21019	enhancer	E3889	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15056	0.78493		KIF5B	chr10	32009014	32056425	36793	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1662
enhrx-42380	chr12	111430561	111430562	110992757	110992758	9308	hg38	N/A	enh96355	N/A	Enhatls45782	enhancer	E3890	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19403	0.78565		CUX2	chr12	111034164	111350554	39034	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7690
enhrx-64872	chr16	67931105	67931106	67897202	67897203	9309	hg38	N/A	enh31888	N/A	Enhatls69626	enhancer	E3891	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031961	0.78578		PSKH1	chr16	67893253	67929676	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5167
enhrx-159572	chr8	72234896	72234897	71322661	71322662	9310	hg38	N/A	N/A	N/A	Enhatls170450	enhancer	E3892	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.09784	0.78578		EYA1	chr8	71197432	71548136	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3363
enhrx-17114	chr1	241161944	241161945	240998644	240998645	9311	hg38	N/A	N/A	N/A	Enhatls18726	enhancer	E3893	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026775	0.78578		RGS7	chr1	240767635	241357374	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17113
enhrx-89172	chr2	26299245	26299246	26076376	26076377	9312	hg38	N/A	enh5372	N/A	Enhatls95530	enhancer	E3894	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042789	0.78588		RAB10	chr2	26034083	26137454	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1098
enhrx-57582	chr15	72785765	72785766	72493424	72493425	9313	hg38	N/A	enh31494	N/A	Enhatls61946	enhancer	E3895	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16	0.78666		ARIH1	chr15	72474329	72602987	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4284
enhrx-65968	chr16	81935258	81935259	81901653	81901654	9314	hg38	N/A	N/A	N/A	Enhatls70815	enhancer	E3896	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08002	0.78667		PLCG2	chr16	81779278	81962685	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6263
enhrx-130906	chr5	15334838	15334839	15334729	15334730	9315	hg38	N/A	N/A	N/A	Enhatls139924	enhancer	E3897	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.118	0.78667		FBXL7	chr5	15500179	15939795	137024	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	697
enhrx-137697	chr5	174070047	174070048	174643044	174643045	9316	hg38	N/A	enh97803	N/A	Enhatls147175	enhancer	E3898	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13794	0.78667		MSX2	chr5	174724581	174730896	77390	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-115441	chr3	52466986	52466987	52432970	52432971	9317	hg38	N/A	N/A	N/A	Enhatls123504	enhancer	E3899	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.042601	0.78723		SEMA3G	chr3	52433034	52445103	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3570
enhrx-119488	chr3	139031870	139031871	139313028	139313029	9318	hg38	N/A	enh20980	N/A	Enhatls127858	enhancer	E3900	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0033786	0.78723		MRPS22	chr3	139005805	139360497	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7617
enhrx-20356	chr10	61704482	61704483	59944724	59944725	9319	hg38	N/A	enh96088	N/A	Enhatls22421	enhancer	E3901	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016898	0.7885		CCDC6	chr10	59788746	59906556	37152	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2791
enhrx-65007	chr16	68778848	68778849	68744945	68744946	9320	hg38	N/A	enh16743	fant50838	Enhatls69769	enhancer	E3902	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030478	0.7885		CDH1	chr16	68737291	68835537	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5302
enhrx-19982	chr10	50013662	50013663	48805617	48805618	9321	hg38	N/A	enh107302	N/A	Enhatls21946	enhancer	E3903	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069953	0.7885		WDFY4	chr10	48684872	48982956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2417
enhrx-92375	chr2	85624168	85624169	85397045	85397046	9322	hg38	N/A	N/A	fant7694	Enhatls98967	enhancer	E3904	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.06784	0.7885		CAPG	chr2	85394752	85418432	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4301
enhrx-131700	chr5	40415218	40415219	40415116	40415117	9323	hg38	N/A	enh22190	N/A	Enhatls140778	enhancer	E3905	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11239	0.7885		TTC33	chr5	40512332	40755963	96144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1491
enhrx-22921	chr10	101311034	101311035	99551277	99551278	9324	hg38	N/A	enh43385	N/A	Enhatls25173	enhancer	E3906	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061059	0.78894		NKX2-3	chr10	99532941	99536524	9531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5356
enhrx-161609	chr8	126123268	126123269	125111026	125111027	9325	hg38	N/A	enh41537	N/A	Enhatls172603	enhancer	E3907	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062364	0.78912		NSMCE2	chr8	125091678	125367120	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5400
enhrx-129826	chr4	179384097	179384098	178462943	178462944	9326	hg38	N/A	N/A	N/A	Enhatls138778	enhancer	E3908	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059986	0.78945		AGA	chr4	177430773	177442437	973656	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7370
enhrx-52515	chr14	97080859	97080860	96614522	96614523	9327	hg38	N/A	enh75584	N/A	Enhatls56638	enhancer	E3909	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080645	0.78955		PAPOLA	chr14	96502381	96567116	45553	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4472
enhrx-165955	chr9	94600355	94600356	91838073	91838074	9328	hg38	N/A	enh49516	N/A	Enhatls177607	enhancer	E3910	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05137	0.78955		ROR2	chr9	91563090	91950228	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3222
enhrx-171705	chrX	31838992	31838993	31820875	31820876	9329	hg38	N/A	N/A	N/A	Enhatls183736	enhancer	E3911	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056959	0.78955		DMD	chrX	31119218	33339609	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1422
enhrx-89578	chr2	28884727	28884728	28661861	28661862	9330	hg38	N/A	enh18394	N/A	Enhatls95960	enhancer	E3912	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00086042	0.78955		PLB1	chr2	28457144	28644142	73	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1504
enhrx-5239	chr1	46337955	46337956	45872283	45872284	9331	hg38	N/A	enh326	N/A	Enhatls5744	enhancer	E3913	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04161	0.78955		MAST2	chr1	45803611	46036122	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5238
enhrx-18654	chr10	21473342	21473343	21184413	21184414	9332	hg38	N/A	enh13032	N/A	Enhatls20412	enhancer	E3914	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066292	0.78955		NEBL	chr10	20779972	21174187	5350	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1089
enhrx-99583	chr2	217912079	217912080	217047356	217047357	9333	hg38	N/A	enh99781	N/A	Enhatls106542	enhancer	E3915	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079311	0.78955		TNP1	chr2	216859457	216860064	183759	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11509
enhrx-57462	chr15	71984291	71984292	71691952	71691953	9334	hg38	N/A	enh31489	N/A	N/A	enhancer	E3916	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17003	0.78965		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4164
enhrx-1185	chr1	10695533	10695534	10635476	10635477	9335	hg38	N/A	N/A	N/A	Enhatls1284	enhancer	E3917	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10084	0.78965		CASZ1	chr1	10636603	10796650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1184
enhrx-167572	chr9	117387200	117387201	114624920	114624921	9336	hg38	N/A	N/A	N/A	Enhatls179340	enhancer	E3918	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011794	0.78965		TMEM268	chr9	114611205	114646422	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4839
enhrx-95180	chr2	134523528	134523529	133765957	133765958	9337	hg38	N/A	enh62847	N/A	Enhatls101913	enhancer	E3919	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032966	0.79089		NCKAP5	chr2	132671787	133568463	195255	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7106
enhrx-19606	chr10	44691180	44691181	44195732	44195733	9338	hg38	N/A	enh28039	N/A	Enhatls21411	enhancer	E3920	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082046	0.79089		CXCL12	chr10	44370164	44385097	169007	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2041
enhrx-98915	chr2	205348392	205348393	204483669	204483670	9339	hg38	N/A	N/A	N/A	Enhatls105834	enhancer	E3921	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049198	0.79089		PARD3B	chr2	204545474	205620162	59493	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10841
enhrx-109318	chr22	27936430	27936431	27540469	27540470	9340	hg38	N/A	N/A	N/A	Enhatls116986	enhancer	E3922	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050048	0.79089		MN1	chr22	27748276	27801756	195713	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1149
enhrx-153444	chr7	112410345	112410346	112770290	112770291	9341	hg38	N/A	enh98056	N/A	Enhatls163968	enhancer	E3923	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00099344	0.79089		TMEM168	chr7	112762376	112790423	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6256
enhrx-78443	chr18	59555301	59555302	61888068	61888069	9342	hg38	N/A	N/A	N/A	Enhatls84162	enhancer	E3924	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042518	0.79089		RNF152	chr18	61808066	61894231	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2461
enhrx-149032	chr7	33709048	33709049	33669436	33669437	9343	hg38	N/A	enh40039	N/A	Enhatls159278	enhancer	E3925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04077	0.79132		BBS9	chr7	33109556	33635767	33569	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1844
enhrx-58436	chr15	81691712	81691713	81399371	81399372	9344	hg38	N/A	enh52128	N/A	Enhatls62864	enhancer	E3926	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076188	0.79132		TMC3	chr15	81331087	81374213	18512	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5138
enhrx-40946	chr12	93918728	93918729	93524952	93524953	9345	hg38	N/A	enh57622	N/A	Enhatls44256	enhancer	E3927	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14253	0.79132		MRPL42	chr12	93467513	93516214	1776	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6256
enhrx-116111	chr3	61630915	61630916	61645241	61645242	9346	hg38	N/A	enh70612	N/A	Enhatls124243	enhancer	E3928	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.060655	0.79161		PTPRG	chr3	61561570	62297609	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4240
enhrx-128343	chr4	139177936	139177937	138256782	138256783	9347	hg38	N/A	enh55002	N/A	Enhatls137239	enhancer	E3929	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10605	0.79161		SLC7A11	chr4	138164096	138242349	9817	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5887
enhrx-100927	chr2	236424169	236424170	235515525	235515526	9348	hg38	N/A	enh19364	N/A	Enhatls107964	enhancer	E3930	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.11958	0.79188		AGAP1	chr2	235494042	236131793	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12853
enhrx-116484	chr3	72871288	72871289	72822137	72822138	9349	hg38	N/A	enh7335	N/A	Enhatls124664	enhancer	E3931	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080854	0.79201		SHQ1	chr3	72749276	72861914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4613
enhrx-17375	chr1	246772188	246772189	246608886	246608887	9350	hg38	N/A	enh12872	N/A	Enhatls19002	enhancer	E3932	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032507	0.79201		CNST	chr1	246566455	246668595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17374
enhrx-163372	chr9	15352550	15352551	15352552	15352553	9351	hg38	N/A	enh49474	N/A	Enhatls174453	enhancer	E3933	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029412	0.79201		TTC39B	chr9	15163621	15307360	37588	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	639
enhrx-111287	chr22	45152056	45152057	44756176	44756177	9352	hg38	N/A	enh20249	N/A	Enhatls119086	enhancer	E3934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033779	0.79201		PRR5-ARHGAP8	chr22	44702232	44862706	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3118
enhrx-111287	chr22	45152056	45152057	44756176	44756177	9353	hg38	N/A	enh20249	N/A	Enhatls119086	enhancer	E3934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033779	0.79201		ARHGAP8	chr22	44752557	44862788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3118
enhrx-65686	chr16	75130772	75130773	75096874	75096875	9354	hg38	N/A	enh16787	N/A	Enhatls70486	enhancer	E3935	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033296	0.79201		ZNRF1	chr16	74999023	75110994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5981
enhrx-170875	chrX	13026640	13026641	13008521	13008522	9355	hg38	N/A	enh11118	N/A	Enhatls182848	enhancer	E3936	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23287	0.79201		FAM9C	chrX	13035616	13044682	18661	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	592
enhrx-120298	chr3	156661444	156661445	156943655	156943656	9356	hg38	N/A	N/A	N/A	Enhatls128711	enhancer	E3937	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031935	0.79214		LEKR1	chr3	156826299	157046129	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8427
enhrx-31725	chr11	78665425	78665426	78954380	78954381	9357	hg38	N/A	enh28902	N/A	Enhatls34474	enhancer	E3938	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038395	0.79214		TENM4	chr11	78652828	79441030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6394
enhrx-40889	chr12	92686017	92686018	92292241	92292242	9358	hg38	N/A	enh29861	N/A	Enhatls44191	enhancer	E3939	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060984	0.79214		BTG1	chr12	92140277	92145846	140684	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6199
enhrx-106418	chr21	23341353	23341354	21969034	21969035	9359	hg38	N/A	enh97181	N/A	Enhatls113781	enhancer	E3940	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012318	0.79228		NCAM2	chr21	20998408	21543329	423618	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	301
enhrx-28001	chr11	40350931	40350932	40329381	40329382	9360	hg38	N/A	enh28787	fant38427	Enhatls30472	enhancer	E3941	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011377	0.79257		LRRC4C	chr11	40114202	41459773	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2670
enhrx-68573	chr17	13956593	13956594	14053276	14053277	9361	hg38	N/A	enh92711	N/A	Enhatls73589	enhancer	E3942	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0071503	0.79257		COX10	chr17	14069495	14208677	14018	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-56287	chr15	56382080	56382081	56089882	56089883	9362	hg38	N/A	N/A	N/A	Enhatls60551	enhancer	E3943	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13038	0.79258		RFX7	chr15	56087279	56245082	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2989
enhrx-72840	chr17	53510709	53510710	55433348	55433349	9363	hg38	N/A	enh4475	fant53055	Enhatls78193	enhancer	E3944	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02147	0.79258		MMD	chr17	55392621	55421924	11307	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6109
enhrx-96259	chr2	162617913	162617914	161761403	161761404	9364	hg38	N/A	enh96998	N/A	Enhatls103047	enhancer	E3945	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096299	0.79258		SLC4A10	chr2	161624334	161985282	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8185
enhrx-139006	chr6	14317322	14317323	14317091	14317092	9365	hg38	N/A	enh55651	N/A	Enhatls148609	enhancer	E3946	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11824	0.79271		CD83	chr6	14117255	14136918	176732	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	594
enhrx-144911	chr6	126821158	126821159	126500012	126500013	9366	hg38	N/A	N/A	N/A	Enhatls154860	enhancer	E3947	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056484	0.79271		CENPW	chr6	126340114	126348875	134530	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6499
enhrx-133060	chr5	73088809	73088810	73792984	73792985	9367	hg38	N/A	enh55323	N/A	Enhatls142176	enhancer	E3948	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.070004	0.79286		ARHGEF28	chr5	73626157	73941993	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2851
enhrx-23681	chr10	109371060	109371061	107611302	107611303	9368	hg38	N/A	enh79717	fant36951	Enhatls25990	enhancer	E3949	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051488	0.79286		SORCS1	chr10	106573662	107164706	446553	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6116
enhrx-148211	chr7	16920379	16920380	16880755	16880756	9369	hg38	N/A	N/A	N/A	Enhatls158384	enhancer	E3950	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11583	0.79286		AGR3	chr7	16859411	16881987	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1023
enhrx-135674	chr5	136642812	136642813	137307123	137307124	9370	hg38	N/A	enh22607	N/A	Enhatls144946	enhancer	E3951	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022904	0.79286		SPOCK1	chr5	136975297	137499326	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5465
enhrx-132209	chr5	55230114	55230115	55934286	55934287	9371	hg38	N/A	N/A	fant18534	Enhatls141293	enhancer	E3952	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066781	0.79341		IL6ST	chr5	55935094	55995018	580	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2000
enhrx-170892	chrX	13625960	13625961	13607841	13607842	9372	hg38	N/A	N/A	N/A	Enhatls182869	enhancer	E3953	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074473	0.79341		EGFL6	chrX	13569600	13633575	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	609
enhrx-139234	chr6	22467161	22467162	22466932	22466933	9373	hg38	N/A	enh38907	N/A	Enhatls148858	enhancer	E3954	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044362	0.79341		HDGFL1	chr6	22569565	22571666	95540	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	822
enhrx-19227	chr10	32460373	32460374	32171445	32171446	9374	hg38	N/A	enh13133	fant35357	Enhatls21019	enhancer	E3955	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099167	0.79428		EPC1	chr10	32267750	32378798	96228	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1662
enhrx-170881	chrX	13082943	13082944	13064824	13064825	9375	hg38	N/A	enh98311	N/A	Enhatls182854	enhancer	E3956	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093074	0.79429		FAM9C	chrX	13035616	13044682	17985	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	598
enhrx-137186	chr5	158945552	158945553	159518544	159518545	9376	hg38	N/A	enh63486	N/A	Enhatls146605	enhancer	E3957	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015427	0.79429		IL12B	chr5	159314779	159330862	187404	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6977
enhrx-49228	chr14	38900562	38900563	38431358	38431359	9377	hg38	N/A	N/A	N/A	Enhatls53128	enhancer	E3958	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11588	0.79435		CLEC14A	chr14	38253999	38256093	169022	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1185
enhrx-77199	chr18	24155991	24155992	26576027	26576028	9378	hg38	N/A	enh58796	N/A	Enhatls82851	enhancer	E3959	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25761	0.79435		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-143406	chr6	88558474	88558475	87848756	87848757	9379	hg38	N/A	enh89023	N/A	Enhatls153279	enhancer	E3960	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022746	0.79435		AKIRIN2	chr6	87674859	87702233	144415	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4994
enhrx-75937	chr17	80796458	80796459	82838582	82838583	9380	hg38	N/A	enh17456	fant54297	Enhatls81483	enhancer	E3961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10862	0.79435		TBCD	chr17	82752041	82945914	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9206
enhrx-75937	chr17	80796458	80796459	82838582	82838583	9381	hg38	N/A	enh17456	fant54297	Enhatls81483	enhancer	E3961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10862	0.79435		ZNF750	chr17	82829433	82840022	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9206
enhrx-27297	chr11	20003060	20003061	19981514	19981515	9382	hg38	N/A	enh13836	N/A	Enhatls29732	enhancer	E3962	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057763	0.7946		NAV2	chr11	19350723	20121601	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1966
enhrx-123700	chr4	19616789	19616790	19615166	19615167	9383	hg38	N/A	enh105568	N/A	Enhatls132383	enhancer	E3963	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08761	0.7946		SLIT2	chr4	20251904	20620561	634593	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1244
enhrx-143354	chr6	88131496	88131497	87421778	87421779	9384	hg38	N/A	enh23400	N/A	Enhatls153226	enhancer	E3964	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07419	0.79485		CFAP206	chr6	87407971	87464465	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4942
enhrx-120416	chr3	159710553	159710554	159992766	159992767	9385	hg38	N/A	N/A	N/A	Enhatls128844	enhancer	E3965	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089829	0.79485		IL12A	chr3	159988834	159996019	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8545
enhrx-153701	chr7	121061214	121061215	121421160	121421161	9386	hg38	N/A	enh24468	N/A	Enhatls164258	enhancer	E3966	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033966	0.79485		FAM3C	chr7	121348877	121396364	21208	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6513
enhrx-96043	chr2	159347230	159347231	158490718	158490719	9387	hg38	N/A	enh33858	N/A	Enhatls102813	enhancer	E3967	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18066	0.79563		PKP4	chr2	158456951	158682879	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7969
enhrx-129829	chr4	180719078	180719079	179797925	179797926	9388	hg38	N/A	N/A	N/A	Enhatls138781	enhancer	E3968	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0075933	0.79563		AGA	chr4	177430773	177442437	2322666	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7373
enhrx-149134	chr7	36201813	36201814	36162204	36162205	9389	hg38	N/A	enh9733	N/A	Enhatls159398	enhancer	E3969	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068716	0.79563		EEPD1	chr7	36153253	36301538	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1946
enhrx-165318	chr9	77716235	77716236	75101319	75101320	9390	hg38	N/A	enh25607	N/A	Enhatls176918	enhancer	E3970	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0057216	0.79563		OSTF1	chr9	75088513	75147265	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2585
enhrx-167676	chr9	120162534	120162535	117400256	117400257	9391	hg38	N/A	enh25961	N/A	Enhatls179462	enhancer	E3971	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07801	0.79564		ASTN2	chr9	116423111	117415070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4943
enhrx-88719	chr2	16152978	16152979	16012856	16012857	9392	hg38	N/A	enh18295	fant6080	Enhatls95051	enhancer	E3972	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042384	0.79564		MYCN	chr2	15940549	15947007	65766	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	645
enhrx-88738	chr2	17795993	17795994	17614726	17614727	9393	hg38	N/A	enh33106	N/A	Enhatls95073	enhancer	E3973	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033075	0.79564		VSNL1	chr2	17539125	17657018	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	664
enhrx-79158	chr19	752799	752800	752799	752800	9394	hg38	N/A	enh44618	fant55728	Enhatls84912	enhancer	E3974	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0087198	0.79595		MISP	chr19	751111	764318	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	128
enhrx-170886	chrX	13365037	13365038	13346918	13346919	9395	hg38	N/A	enh42409	N/A	Enhatls182863	enhancer	E3975	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0079294	0.79612		ATXN3L	chrX	13318646	13320053	21769	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	603
enhrx-107884	chr21	46205685	46205686	44785770	44785771	9396	hg38	N/A	N/A	N/A	Enhatls115367	enhancer	E3976	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058755	0.79612		UBE2G2	chr21	44768579	44801820	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1767
enhrx-37731	chr12	47499880	47499881	47106097	47106098	9397	hg38	N/A	enh96293	N/A	Enhatls40860	enhancer	E3977	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10115	0.79612		PCED1B	chr12	47079602	47236662	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3041
enhrx-44819	chr13	25808140	25808141	25234002	25234003	9398	hg38	N/A	enh2726	N/A	Enhatls48354	enhancer	E3978	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080452	0.79671		MTMR6	chr13	25246221	25287510	6885	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	441
enhrx-172180	chrX	44764693	44764694	44905448	44905449	9399	hg38	N/A	enh11190	N/A	Enhatls184223	enhancer	E3979	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090082	0.79671		KDM6A	chrX	44873187	45112779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1897
enhrx-129533	chr4	169596204	169596205	168675053	168675054	9400	hg38	N/A	enh21925	fant17348	Enhatls138463	enhancer	E3980	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.073955	0.79671		PALLD	chr4	168497051	168928457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7077
enhrx-57390	chr15	70280324	70280325	69987985	69987986	9401	hg38	N/A	enh3695	N/A	Enhatls61752	enhancer	E3981	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10874	0.79671		TLE3	chr15	70047789	70098176	50613	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4092
enhrx-40951	chr12	94453634	94453635	94059858	94059859	9402	hg38	N/A	enh29878	N/A	Enhatls44266	enhancer	E3982	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024123	0.79695		PLXNC1	chr12	94148576	94307675	83078	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6261
enhrx-130714	chr5	10551602	10551603	10551490	10551491	9403	hg38	N/A	enh37597	fant17921	Enhatls139728	enhancer	E3983	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18283	0.7971		ANKRD33B	chr5	10564069	10657816	12311	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-116307	chr3	65939289	65939290	65953614	65953615	9404	hg38	N/A	enh20668	fant12389	Enhatls124456	enhancer	E3984	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02264	0.79755		MAGI1	chr3	65353524	66038918	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4436
enhrx-111719	chr22	50835683	50835684	50397254	50397255	9405	hg38	N/A	enh20280	N/A	Enhatls119560	enhancer	E3985	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.009477	0.79755		PPP6R2	chr22	50343303	50445090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3550
enhrx-12292	chr1	168736018	168736019	168766780	168766781	9406	hg38	N/A	enh58165	N/A	Enhatls13615	enhancer	E3986	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.02969	0.79755		DPT	chr1	168695467	168729206	29642	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12291
enhrx-152309	chr7	99601756	99601757	100004133	100004134	9407	hg38	N/A	enh24362	fant27160	Enhatls162780	enhancer	E3987	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14185	0.79755		ZKSCAN1	chr7	100015571	100041689	11360	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5121
enhrx-115071	chr3	50165046	50165047	50127613	50127614	9408	hg38	N/A	enh48693	N/A	Enhatls123117	enhancer	E3988	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02614	0.79755		RBM5	chr3	50088918	50119021	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3200
enhrx-24754	chr10	126567094	126567095	124878525	124878526	9409	hg38	N/A	enh108448	N/A	Enhatls27104	enhancer	E3989	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.15393	0.79755		ABRAXAS2	chr10	124801818	124836667	37070	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7189
enhrx-117934	chr3	120429405	120429406	120710558	120710559	9410	hg38	N/A	N/A	N/A	Enhatls126207	enhancer	E3990	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.031147	0.79755		RABL3	chr3	120684937	120742520	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6063
enhrx-17719	chr10	3627357	3627358	3585165	3585166	9411	hg38	N/A	enh96004	N/A	Enhatls19357	enhancer	E3991	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03685	0.79755		KLF6	chr10	3775995	3785281	188633	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	154
enhrx-13473	chr1	184899230	184899231	184930098	184930099	9412	hg38	N/A	enh12471	N/A	Enhatls14879	enhancer	E3992	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061577	0.79755		NIBAN1	chr1	184790723	184974508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13472
enhrx-58130	chr15	78394299	78394300	78101957	78101958	9413	hg38	N/A	enh16353	N/A	Enhatls62541	enhancer	E3993	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092056	0.79755		SH2D7	chr15	78077807	78104370	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4832
enhrx-167068	chr9	112515772	112515773	109753492	109753493	9414	hg38	N/A	N/A	N/A	Enhatls178816	enhancer	E3994	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048333	0.79755		PALM2AKAP2	chr9	109498324	110172512	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4335
enhrx-135963	chr5	139707383	139707384	140327798	140327799	9415	hg38	N/A	enh22636	N/A	Enhatls145252	enhancer	E3995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0096006	0.79767		HBEGF	chr5	140332842	140346603	793	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5754
enhrx-159821	chr8	82016720	82016721	81104485	81104486	9416	hg38	N/A	enh25100	N/A	Enhatls170722	enhancer	E3996	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014162	0.79767		PAG1	chr8	80967809	81112068	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3612
enhrx-122845	chr4	2585485	2585486	2583758	2583759	9417	hg38	N/A	enh7850	N/A	Enhatls131450	enhancer	E3997	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01809	0.79837		FAM193A	chr4	2536646	2732573	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	389
enhrx-31811	chr11	83359836	83359837	83648793	83648794	9418	hg38	N/A	enh50927	N/A	Enhatls34566	enhancer	E3998	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04619	0.79837		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6480
enhrx-158558	chr8	42656716	42656717	42801573	42801574	9419	hg38	N/A	enh61557	N/A	Enhatls169398	enhancer	E3999	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082097	0.79837		CHRNA6	chr8	42752619	42796392	3155	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2349
enhrx-63909	chr16	54543431	54543432	54509519	54509520	9420	hg38	N/A	enh31812	N/A	Enhatls68591	enhancer	E4000	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.099064	0.79837		IRX3	chr16	54283303	54286787	220748	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4204
enhrx-84777	chr19	40759664	40759665	40253757	40253758	9421	hg38	N/A	enh69560	N/A	Enhatls90878	enhancer	E4001	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12261	0.79837		AKT2	chr19	40230316	40285536	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5747
enhrx-19747	chr10	51531259	51531260	46064561	46064562	9422	hg38	N/A	N/A	N/A	Enhatls22122	enhancer	E4002	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11922	0.79837		MSMB	chr10	46033306	46048180	8697	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2182
enhrx-40651	chr12	81775964	81775965	81382185	81382186	9423	hg38	N/A	N/A	N/A	Enhatls43939	enhancer	E4003	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.059101	0.79837		PPFIA2	chr12	81257974	81759553	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5961
enhrx-99586	chr2	218261216	218261217	217396493	217396494	9424	hg38	N/A	enh34264	fant10090	Enhatls106547	enhancer	E4004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026292	0.7984		TNS1	chr2	217799587	218033982	403024	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11512
enhrx-161197	chr8	118960151	118960152	117947912	117947913	9425	hg38	N/A	enh25236	N/A	Enhatls172165	enhancer	E4005	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07197	0.7984		EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4988
enhrx-77205	chr18	24344762	24344763	26764798	26764799	9426	hg38	N/A	enh17619	N/A	Enhatls82857	enhancer	E4006	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10559	0.79858		AQP4	chr18	26852042	26865752	85092	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1223
enhrx-77718	chr18	42053961	42053962	44473996	44473997	9427	hg38	N/A	N/A	N/A	Enhatls83386	enhancer	E4007	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013417	0.79937		SETBP1	chr18	44680172	45068510	184813	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1736
enhrx-145758	chr6	144651843	144651844	144330707	144330708	9428	hg38	N/A	enh9410	N/A	Enhatls155802	enhancer	E4008	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099895	0.79937		UTRN	chr6	144285334	144853034	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7346
enhrx-60430	chr16	2526979	2526980	2476978	2476979	9429	hg38	N/A	enh91090	N/A	Enhatls64990	enhancer	E4009	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15376	0.79937		TBC1D24	chr16	2475050	2505734	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	725
enhrx-167274	chr9	114723405	114723406	111961125	111961126	9430	hg38	N/A	enh25908	fant33277	Enhatls179021	enhancer	E4010	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11257	0.7996		UGCG	chr9	111896813	111935369	25677	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4541
enhrx-104331	chr20	41173792	41173793	42545152	42545153	9431	hg38	N/A	enh88608	N/A	Enhatls111580	enhancer	E4011	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.067232	0.7996		PTPRT	chr20	42072751	43189970	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2759
enhrx-57387	chr15	70131618	70131619	69839279	69839280	9432	hg38	N/A	N/A	N/A	Enhatls61749	enhancer	E4012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010743	0.79961		TLE3	chr15	70047789	70098176	207049	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4089
enhrx-17152	chr1	241913440	241913441	241750138	241750139	9433	hg38	N/A	enh12829	N/A	Enhatls18771	enhancer	E4013	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018753	0.79961		WDR64	chr1	241652277	241802777	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17151
enhrx-167267	chr9	114601977	114601978	111839697	111839698	9434	hg38	N/A	enh63927	N/A	Enhatls179014	enhancer	E4014	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0702	0.79961		SHOC1	chr9	111686170	111795008	39375	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4534
enhrx-131877	chr5	43310050	43310051	43309948	43309949	9435	hg38	N/A	N/A	N/A	Enhatls140958	enhancer	E4015	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091699	0.79995		HMGCS1	chr5	43287469	43313512	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1668
enhrx-36662	chr12	23340052	23340053	23187118	23187119	9436	hg38	N/A	N/A	N/A	Enhatls39743	enhancer	E4016	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13651	0.79995		SOX5	chr12	23529503	24562487	341378	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1972
enhrx-101765	chr20	1986734	1986735	2006088	2006089	9437	hg38	N/A	N/A	N/A	Enhatls108827	enhancer	E4017	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11084	0.80044		PDYN	chr20	1978756	1994285	5000	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	193
enhrx-112657	chr3	14265286	14265287	14223786	14223787	9438	hg38	N/A	enh20364	N/A	Enhatls120552	enhancer	E4018	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026253	0.80058		LSM3	chr3	14178816	14201122	20024	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	786
enhrx-165912	chr9	92762487	92762488	90000205	90000206	9439	hg38	N/A	enh25730	N/A	Enhatls177554	enhancer	E4019	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10219	0.80058		GADD45G	chr9	89605011	89606555	393504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3179
enhrx-161363	chr8	121822100	121822101	120809860	120809861	9440	hg38	N/A	enh10497	N/A	Enhatls172342	enhancer	E4020	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054366	0.80058		SNTB1	chr8	120535744	120813273	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5154
enhrx-114322	chr3	46354815	46354816	46313324	46313325	9441	hg38	N/A	enh63135	N/A	Enhatls122341	enhancer	E4021	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0095588	0.80059		CCR2	chr3	46354110	46360940	37327	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2451
enhrx-120095	chr3	151120207	151120208	151402419	151402420	9442	hg38	N/A	enh113332	N/A	Enhatls128492	enhancer	E4022	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015161	0.80081		MED12L	chr3	151085663	151437072	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8224
enhrx-112725	chr3	14954755	14954756	14913248	14913249	9443	hg38	N/A	N/A	N/A	Enhatls120623	enhancer	E4023	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026801	0.80081		FGD5	chr3	14810852	14934571	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	854
enhrx-7372	chr1	85313101	85313102	84847418	84847419	9444	hg38	N/A	enh11991	fant2166	Enhatls7999	enhancer	E4024	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051699	0.80169		LPAR3	chr1	84811601	84893206	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7371
enhrx-52683	chr14	101874997	101874998	101408660	101408661	9445	hg38	N/A	enh60522	N/A	N/A	enhancer	E4025	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11239	0.80169		DIO3	chr14	101560138	101563452	147216	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4640
enhrx-164997	chr9	71108060	71108061	68493144	68493145	9446	hg38	N/A	enh110469	N/A	Enhatls176564	enhancer	E4026	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15879	0.80195		PGM5	chr9	68356610	68531061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2264
enhrx-130974	chr5	16889950	16889951	16889841	16889842	9447	hg38	N/A	enh22076	N/A	Enhatls139996	enhancer	E4027	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018684	0.80196		MYO10	chr5	16661906	16936288	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	765
enhrx-21455	chr10	79152909	79152910	77393151	77393152	9448	hg38	N/A	enh28256	fant36204	Enhatls23603	enhancer	E4028	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050909	0.80196		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-45027	chr13	29034205	29034206	28460068	28460069	9449	hg38	N/A	N/A	N/A	Enhatls48575	enhancer	E4029	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075212	0.80213		FLT1	chr13	28300345	28495145	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	649
enhrx-103998	chr20	35856059	35856060	37227656	37227657	9450	hg38	N/A	N/A	N/A	Enhatls111228	enhancer	E4030	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085774	0.80213		RPN2	chr20	37178409	37241619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2426
enhrx-161932	chr8	135747201	135747202	134734958	134734959	9451	hg38	N/A	enh25366	N/A	Enhatls172977	enhancer	E4031	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06229	0.80261		ZFAT	chr8	134477787	134713031	12672	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5723
enhrx-51243	chr14	74921369	74921370	74454666	74454667	9452	hg38	N/A	N/A	N/A	Enhatls55258	enhancer	E4032	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09051	0.80261		NPC2	chr14	74476191	74494177	10191	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3200
enhrx-94583	chr2	121387966	121387967	120630390	120630391	9453	hg38	N/A	enh81795	N/A	Enhatls101279	enhancer	E4033	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03895	0.80261		GLI2	chr2	120735622	120992653	100244	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-161645	chr8	128832476	128832477	127820230	127820231	9454	hg38	N/A	enh10528	N/A	Enhatls172652	enhancer	E4034	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.079844	0.80329		MYC	chr8	127735433	127742951	56792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5436
enhrx-146867	chr6	166618437	166618438	166204949	166204950	9455	hg38	N/A	enh9535	N/A	Enhatls156992	enhancer	E4035	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042212	0.80423		TBXT	chr6	166157655	166168700	30418	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8455
enhrx-11629	chr1	160100886	160100887	160131096	160131097	9456	hg38	N/A	N/A	N/A	Enhatls12908	enhancer	E4036	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025436	0.80431		ATP1A2	chr1	160115758	160143591	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11628
enhrx-41444	chr12	101830157	101830158	101436379	101436380	9457	hg38	N/A	N/A	N/A	Enhatls44784	enhancer	E4037	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18403	0.80431		ARL1	chr12	101393115	101407772	5671	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6754
enhrx-100976	chr2	237813784	237813785	236905141	236905142	9458	hg38	N/A	enh82141	N/A	Enhatls108013	enhancer	E4038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052811	0.80452		COPS8	chr2	237085881	237100474	178770	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12902
enhrx-92502	chr2	86681129	86681130	86454006	86454007	9459	hg38	N/A	N/A	N/A	Enhatls99110	enhancer	E4039	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038548	0.80453		KDM3A	chr2	86440646	86492716	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4428
enhrx-150699	chr7	74050030	74050031	74635714	74635715	9460	hg38	N/A	enh24250	N/A	Enhatls161083	enhancer	E4040	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21952	0.80454		GTF2I	chr7	74650230	74760692	14504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3511
enhrx-31582	chr11	77118915	77118916	77407870	77407871	9461	hg38	N/A	enh43580	N/A	Enhatls34324	enhancer	E4041	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23754	0.80454		PAK1	chr11	77322016	77474635	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6251
enhrx-45752	chr13	42870225	42870226	42296089	42296090	9462	hg38	N/A	N/A	N/A	Enhatls49375	enhancer	E4042	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12284	0.80454		AKAP11	chr13	42272151	42323261	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1374
enhrx-64966	chr16	68362150	68362151	68328247	68328248	9463	hg38	N/A	enh16741	N/A	Enhatls69726	enhancer	E4043	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015644	0.80454		PRMT7	chr16	68311009	68358584	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5261
enhrx-34634	chr11	134076832	134076833	134206938	134206939	9464	hg38	N/A	N/A	N/A	Enhatls37580	enhancer	E4044	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0036698	0.80496		NCAPD3	chr11	134150112	134225504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9303
enhrx-136962	chr5	154222728	154222729	154843168	154843169	9465	hg38	N/A	enh66105	N/A	Enhatls146357	enhancer	E4045	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0062239	0.80496		FAXDC2	chr5	154818491	154859252	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6753
enhrx-47831	chr13	113667866	113667867	113013552	113013553	9466	hg38	N/A	N/A	N/A	Enhatls51654	enhancer	E4046	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030277	0.80501		MCF2L	chr13	112894377	113099742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3453
enhrx-30898	chr11	70652127	70652128	70806022	70806023	9467	hg38	N/A	N/A	N/A	Enhatls33593	enhancer	E4047	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.066694	0.80501		SHANK2	chr11	70467853	71252577	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5567
enhrx-145960	chr6	149451860	149451861	149130724	149130725	9468	hg38	N/A	enh23764	N/A	Enhatls156016	enhancer	E4048	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24822	0.80501		UST	chr6	148747029	149076990	51762	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7548
enhrx-115794	chr3	55560618	55560619	55526590	55526591	9469	hg38	N/A	enh35414	N/A	Enhatls123889	enhancer	E4049	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.095219	0.80501		ERC2	chr3	55508310	56469095	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3923
enhrx-152012	chr7	97678523	97678524	98049211	98049212	9470	hg38	N/A	enh59805	N/A	Enhatls162477	enhancer	E4050	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.057896	0.80501		LMTK2	chr7	98106861	98209638	55350	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4824
enhrx-135460	chr5	133274101	133274102	133938410	133938411	9471	hg38	N/A	enh8690	N/A	Enhatls144705	enhancer	E4051	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021407	0.80501		C5orf15	chr5	133955509	133968625	8466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5251
enhrx-51941	chr14	90980049	90980050	90513705	90513706	9472	hg38	N/A	enh15845	N/A	Enhatls56007	enhancer	E4052	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021485	0.80501		TTC7B	chr14	90524563	90816479	1974	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3898
enhrx-9070	chr1	112519650	112519651	111977028	111977029	9473	hg38	N/A	enh87627	N/A	Enhatls9792	enhancer	E4053	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013019	0.80501		KCND3	chr1	111770661	111989668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9069
enhrx-40888	chr12	91782680	91782681	91388903	91388904	9474	hg38	N/A	enh14873	N/A	Enhatls44185	enhancer	E4054	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021607	0.80501		DCN	chr12	91140483	91182824	198950	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6198
enhrx-117757	chr3	117932965	117932966	118214118	118214119	9475	hg38	N/A	N/A	N/A	Enhatls126030	enhancer	E4055	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075764	0.80501		IGSF11	chr3	118900556	119146068	521859	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5886
enhrx-1157	chr1	10447787	10447788	10387730	10387731	9476	hg38	N/A	enh57	N/A	Enhatls1253	enhancer	E4056	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.050106	0.80501		KIF1B	chr1	10210569	10381603	2805	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1156
enhrx-98915	chr2	204876277	204876278	204011554	204011555	9477	hg38	N/A	enh19137	N/A	Enhatls105834	enhancer	E4057	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012161	0.8052		ICOS	chr2	203936762	203961577	47506	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10841
enhrx-55603	chr15	47733147	47733148	47440950	47440951	9478	hg38	N/A	enh31349	N/A	Enhatls59824	enhancer	E4058	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099868	0.8052		SEMA6D	chr15	47184100	47774228	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2305
enhrx-35010	chr12	3324317	3324318	3215151	3215152	9479	hg38	N/A	enh14460	N/A	Enhatls37999	enhancer	E4059	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072951	0.8052		TSPAN9	chr12	3077354	3286564	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	320
enhrx-156663	chr8	10532607	10532608	10675097	10675098	9480	hg38	N/A	N/A	N/A	Enhatls167356	enhancer	E4060	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092032	0.80521		C8orf74	chr8	10672627	10700590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	454
enhrx-76938	chr18	20451884	20451885	22871921	22871922	9481	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	E4061	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0057247	0.80521		RBBP8	chr18	22798260	23026488	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	956
enhrx-28896	chr11	57546134	57546135	57778662	57778663	9482	hg38	N/A	enh13938	fant38640	Enhatls31418	enhancer	E4062	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04513	0.80637		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-24477	chr10	123822917	123822918	122063402	122063403	9483	hg38	N/A	enh13582	fant37239	Enhatls26845	enhancer	E4063	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16486	0.80637		TACC2	chr10	121989162	122254545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6912
enhrx-40062	chr12	69401766	69401767	69007986	69007987	9484	hg38	N/A	enh14817	N/A	Enhatls43318	enhancer	E4064	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11393	0.80637		CPM	chr12	68842207	68963269	44405	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5372
enhrx-44833	chr13	25876892	25876893	25302754	25302755	9485	hg38	N/A	N/A	N/A	Enhatls48368	enhancer	E4065	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0054936	0.80637		NUP58	chr13	25301523	25349963	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	455
enhrx-160162	chr8	92457221	92457222	91444993	91444994	9486	hg38	N/A	enh85121	N/A	Enhatls171080	enhancer	E4066	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023709	0.80682		SLC26A7	chr8	91209494	91398155	44623	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3953
enhrx-161345	chr8	121484668	121484669	120472428	120472429	9487	hg38	N/A	N/A	N/A	Enhatls172320	enhancer	E4067	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026293	0.80682		MTBP	chr8	120445418	120523636	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5136
enhrx-155966	chr7	154991724	154991725	155200014	155200015	9488	hg38	N/A	N/A	N/A	Enhatls166633	enhancer	E4068	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.44713	0.80699		INSIG1	chr7	155297775	155310235	96281	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8778
enhrx-20354	chr10	61651553	61651554	59891795	59891796	9489	hg38	N/A	N/A	N/A	Enhatls22420	enhancer	E4069	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0080825	0.80699		CCDC6	chr10	59788746	59906556	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-52901	chr14	103577411	103577412	103111074	103111075	9490	hg38	N/A	N/A	fant47374	Enhatls57046	enhancer	E4070	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091636	0.80699		EXOC3L4	chr14	103094724	103110559	311	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4858
enhrx-161645	chr8	128872089	128872090	127859843	127859844	9491	hg38	N/A	enh10529	fant31006	Enhatls172652	enhancer	E4071	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20969	0.80699		MYC	chr8	127735433	127742951	116644	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5436
enhrx-28145	chr11	45001624	45001625	44980073	44980074	9492	hg38	N/A	enh50812	N/A	Enhatls30637	enhancer	E4072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0055367	0.80755		TP53I11	chr11	44932347	44951306	28065	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2814
enhrx-149195	chr7	37011243	37011244	36971638	36971639	9493	hg38	N/A	enh56260	N/A	Enhatls159465	enhancer	E4073	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11141	0.80786		ELMO1	chr7	36852905	37449223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2007
enhrx-59304	chr15	93070608	93070609	92527378	92527379	9494	hg38	N/A	enh96633	N/A	Enhatls63854	enhancer	E4074	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039772	0.80786		ST8SIA2	chr15	92393880	92468728	56508	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6006
enhrx-148798	chr7	30435502	30435503	30395886	30395887	9495	hg38	N/A	enh9720	N/A	Enhatls159025	enhancer	E4075	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062491	0.80786		ZNRF2	chr7	30284596	30367689	23346	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1610
enhrx-78380	chr18	56517743	56517744	58850511	58850512	9496	hg38	N/A	enh17749	N/A	Enhatls84090	enhancer	E4076	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.096966	0.80807		ZNF532	chr18	58862599	58986480	8408	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2398
enhrx-4477	chr1	39861061	39861062	39395389	39395390	9497	hg38	N/A	enh11763	N/A	Enhatls4923	enhancer	E4077	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00018897	0.80807		MACF1	chr1	39081315	39487177	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4476
enhrx-106692	chr21	32986532	32986533	31614219	31614220	9498	hg38	N/A	enh19890	N/A	Enhatls114078	enhancer	E4078	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03897	0.80807		SOD1	chr21	31659665	31668931	44004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	575
enhrx-139234	chr6	22471438	22471439	22471209	22471210	9499	hg38	N/A	enh38907	N/A	Enhatls148858	enhancer	E4079	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15452	0.80807		HDGFL1	chr6	22569565	22571666	95540	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	822
enhrx-64954	chr16	68310071	68310072	68276168	68276169	9500	hg38	N/A	enh4105	N/A	Enhatls69713	enhancer	E4080	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12352	0.80807		SLC7A6	chr16	68264515	68301823	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5249
enhrx-116480	chr3	72279288	72279289	72230137	72230138	9501	hg38	N/A	N/A	N/A	Enhatls124657	enhancer	E4081	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0092777	0.8086		RYBP	chr3	72371824	72446621	139409	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4609
enhrx-163694	chr9	23342505	23342506	23342507	23342508	9502	hg38	N/A	N/A	N/A	Enhatls174796	enhancer	E4082	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017754	0.80879		ELAVL2	chr9	23690103	23826337	199877	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	961
enhrx-97926	chr2	190365619	190365620	189500893	189500894	9503	hg38	N/A	enh53473	N/A	Enhatls104780	enhancer	E4083	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049808	0.8091		WDR75	chr2	189441473	189475552	23248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-88142	chr2	1629284	1629285	1625512	1625513	9504	hg38	N/A	enh32993	N/A	Enhatls94373	enhancer	E4084	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089353	0.8093		PXDN	chr2	1631886	1744515	689	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	68
enhrx-158558	chr8	42669606	42669607	42814463	42814464	9505	hg38	N/A	enh66546	N/A	Enhatls169398	enhancer	E4085	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10298	0.8093		CHRNA6	chr8	42752619	42796392	13949	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2349
enhrx-158870	chr8	54605464	54605465	53692904	53692905	9506	hg38	N/A	enh46572	N/A	Enhatls169714	enhancer	E4086	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11858	0.80936		ATP6V1H	chr8	53715542	53843558	22288	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2661
enhrx-65105	chr16	69757867	69757868	69723964	69723965	9507	hg38	N/A	enh86220	N/A	Enhatls69873	enhancer	E4087	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073383	0.80949		NQO1	chr16	69706995	69726668	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5400
enhrx-34339	chr11	125985991	125985992	126116096	126116097	9508	hg38	N/A	enh2086	fant40317	Enhatls37246	enhancer	E4088	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.082519	0.80949		CDON	chr11	125955795	126063335	52722	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-121867	chr3	189699618	189699619	189981829	189981830	9509	hg38	N/A	N/A	N/A	Enhatls130420	enhancer	E4089	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084288	0.80949		P3H2	chr3	189956727	190122437	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9996
enhrx-47730	chr13	111900161	111900162	111247814	111247815	9510	hg38	N/A	enh30705	N/A	Enhatls51552	enhancer	E4090	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.16997	0.80949		ARHGEF7	chr13	111114618	111305737	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3352
enhrx-16222	chr1	228314427	228314428	228126726	228126727	9511	hg38	N/A	N/A	N/A	Enhatls17811	enhancer	E4091	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020782	0.80949		GUK1	chr1	228139961	228148955	11077	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16221
enhrx-6044	chr1	55284976	55284977	54819303	54819304	9512	hg38	N/A	enh108324	N/A	Enhatls6588	enhancer	E4092	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14928	0.80964		CIMAP2	chr1	54806062	54842252	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6043
enhrx-56566	chr15	60943619	60943620	60651420	60651421	9513	hg38	N/A	enh62475	N/A	Enhatls60859	enhancer	E4093	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21108	0.80964		RORA	chr15	60488283	61229302	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3268
enhrx-109742	chr22	31527910	31527911	31131924	31131925	9514	hg38	N/A	N/A	N/A	Enhatls117419	enhancer	E4094	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093018	0.80964		INPP5J	chr22	31122922	31134697	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1573
enhrx-90915	chr2	55206950	55206951	54979814	54979815	9515	hg38	N/A	enh5536	N/A	Enhatls97419	enhancer	E4095	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0405	0.80974		RTN4	chr2	54972186	55112621	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2841
enhrx-21456	chr10	79177342	79177343	77417584	77417585	9516	hg38	N/A	enh28257	N/A	Enhatls23604	enhancer	E4096	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074509	0.81059		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3891
enhrx-105013	chr20	47796060	47796061	49179523	49179524	9517	hg38	N/A	enh70298	N/A	Enhatls112286	enhancer	E4097	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10021	0.8106		STAU1	chr20	49113338	49188367	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3441
enhrx-176115	chrX	124063302	124063303	124929453	124929454	9518	hg38	N/A	N/A	N/A	Enhatls188319	enhancer	E4098	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12496	0.81065		TENM1	chrX	124375902	125204312	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5832
enhrx-72288	chr17	46401256	46401257	48323894	48323895	9519	hg38	N/A	enh52518	N/A	Enhatls77594	enhancer	E4099	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019738	0.81093		SKAP1	chr17	48133441	48430219	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5557
enhrx-105254	chr20	54904138	54904139	56329082	56329083	9520	hg38	N/A	N/A	N/A	Enhatls112571	enhancer	E4100	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21135	0.81093		FAM210B	chr20	56358973	56368663	12565	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3682
enhrx-89044	chr2	24689921	24689922	24467052	24467053	9521	hg38	N/A	enh18346	N/A	Enhatls95391	enhancer	E4101	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01773	0.81093		NCOA1	chr2	24491253	24770702	21832	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	970
enhrx-2280	chr1	19946489	19946490	19619995	19619996	9522	hg38	N/A	enh92029	N/A	Enhatls2539	enhancer	E4102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013298	0.81093		MICOS10	chr1	19484402	19629821	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2279
enhrx-2280	chr1	19946489	19946490	19619995	19619996	9523	hg38	N/A	enh92029	N/A	Enhatls2539	enhancer	E4102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013298	0.81093		NBL1	chr1	19596978	19658456	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2279
enhrx-136193	chr5	142504392	142504393	143124827	143124828	9524	hg38	N/A	enh22669	fant20148	Enhatls145505	enhancer	E4103	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1232	0.81093		ARHGAP26	chr5	142770376	143229011	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5984
enhrx-175762	chrX	117713570	117713571	118579607	118579608	9525	hg38	N/A	N/A	N/A	Enhatls187958	enhancer	E4104	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093715	0.81111		DOCK11	chrX	118495814	118686163	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5479
enhrx-107431	chr21	43074266	43074267	41654106	41654107	9526	hg38	N/A	enh19994	N/A	N/A	enhancer	E4105	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014192	0.81196		RIPK4	chr21	41739368	41767089	75110	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1314
enhrx-107000	chr21	36218193	36218194	34845896	34845897	9527	hg38	N/A	enh19924	fant60060	Enhatls114408	enhancer	E4106	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023328	0.81197		RUNX1	chr21	34787800	36004667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	883
enhrx-23796	chr10	112861791	112861792	111102033	111102034	9528	hg38	N/A	N/A	N/A	Enhatls26118	enhancer	E4107	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017445	0.812		ADRA2A	chr10	111077028	111080907	20411	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6231
enhrx-127317	chr4	106915393	106915394	105994236	105994237	9529	hg38	N/A	enh36888	N/A	Enhatls136168	enhancer	E4108	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018977	0.81204		NPNT	chr4	105894774	106004027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4861
enhrx-156591	chr8	8146795	8146796	8289273	8289274	9530	hg38	N/A	enh10138	N/A	Enhatls167276	enhancer	E4109	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17938	0.81204		PRAG1	chr8	8317735	8386439	28217	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	382
enhrx-129551	chr4	170025481	170025482	169104330	169104331	9531	hg38	N/A	enh37346	N/A	Enhatls138490	enhancer	E4110	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13359	0.81204		SH3RF1	chr4	169094258	169270956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7095
enhrx-59429	chr15	98996145	98996146	98452916	98452917	9532	hg38	N/A	N/A	N/A	Enhatls63995	enhancer	E4111	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2366	0.81204		IGF1R	chr15	98648538	98964530	194563	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6131
enhrx-161710	chr8	131510160	131510161	130497914	130497915	9533	hg38	N/A	enh25329	N/A	Enhatls172740	enhancer	E4112	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084631	0.8122		ASAP1	chr8	130052103	130443674	48281	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5501
enhrx-167432	chr9	116251454	116251455	113489174	113489175	9534	hg38	N/A	enh46844	N/A	Enhatls179187	enhancer	E4113	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049365	0.8122		RGS3	chr9	113444730	113597743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4699
enhrx-12039	chr1	164671627	164671628	164702390	164702391	9535	hg38	N/A	enh12338	N/A	Enhatls13336	enhancer	E4114	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049236	0.8122		PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12038
enhrx-13473	chr1	184874920	184874921	184905787	184905788	9536	hg38	N/A	enh50098	N/A	Enhatls14879	enhancer	E4115	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21862	0.8122		NIBAN1	chr1	184790723	184974508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13472
enhrx-101853	chr20	2732107	2732108	2751461	2751462	9537	hg38	N/A	N/A	N/A	Enhatls108912	enhancer	E4116	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078372	0.8122		EBF4	chr20	2692779	2760108	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	281
enhrx-146854	chr6	166248268	166248269	165834780	165834781	9538	hg38	N/A	enh89066	N/A	Enhatls156981	enhancer	E4117	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035179	0.81249		PDE10A	chr6	165327288	165987965	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8442
enhrx-23960	chr10	115714507	115714508	113954748	113954749	9539	hg38	N/A	enh1520	N/A	Enhatls26304	enhancer	E4118	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19675	0.81249		NHLRC2	chr10	113854660	113917194	34173	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6395
enhrx-148226	chr7	17545868	17545869	17506244	17506245	9540	hg38	N/A	enh56185	N/A	Enhatls158403	enhancer	E4119	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19365	0.8127		AHR	chr7	17132189	17346150	155792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1038
enhrx-116458	chr3	71179415	71179416	71130264	71130265	9541	hg38	N/A	enh7309	N/A	Enhatls124626	enhancer	E4120	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0018588	0.81373		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4587
enhrx-133315	chr5	76517182	76517183	77221357	77221358	9542	hg38	N/A	N/A	N/A	Enhatls142435	enhancer	E4121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075801	0.81393		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-133315	chr5	76517182	76517183	77221357	77221358	9543	hg38	N/A	N/A	N/A	Enhatls142435	enhancer	E4121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075801	0.81393		PDE8B	chr5	77210448	77428256	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-116243	chr3	64241363	64241364	64255687	64255688	9544	hg38	N/A	enh95100	N/A	Enhatls124387	enhancer	E4122	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098442	0.81393		PRICKLE2	chr3	64092235	64445407	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4372
enhrx-171354	chrX	20120270	20120271	20102152	20102153	9545	hg38	N/A	enh110510	N/A	Enhatls183371	enhancer	E4123	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17345	0.81393		MAP7D2	chrX	20006712	20116907	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1071
enhrx-93394	chr2	100683489	100683490	100067027	100067028	9546	hg38	N/A	enh5736	N/A	Enhatls100025	enhancer	E4124	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28907	0.81393		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5320
enhrx-113019	chr3	20464058	20464059	20422566	20422567	9547	hg38	N/A	N/A	N/A	Enhatls120929	enhancer	E4125	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070586	0.81393		SGO1	chr3	20160592	20186206	222398	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1148
enhrx-39330	chr12	57162426	57162427	56768642	56768643	9548	hg38	N/A	enh2390	fant41954	Enhatls42519	enhancer	E4126	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22849	0.81393		HSD17B6	chr12	56752160	56787790	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4640
enhrx-92143	chr2	75777015	75777016	75549889	75549890	9549	hg38	N/A	enh18693	N/A	Enhatls98728	enhancer	E4127	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10893	0.81393		EVA1A	chr2	75492317	75569722	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4069
enhrx-173420	chrX	66832319	66832320	67612477	67612478	9550	hg38	N/A	enh26301	N/A	Enhatls185587	enhancer	E4128	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.093115	0.81458		AR	chrX	67544020	67730619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3137
enhrx-12593	chr1	172291786	172291787	172322646	172322647	9551	hg38	N/A	enh74414	fant3659	Enhatls13926	enhancer	E4129	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017135	0.81458		DNM3	chr1	171817886	172418466	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12592
enhrx-133920	chr5	90882242	90882243	91586425	91586426	9552	hg38	N/A	N/A	N/A	Enhatls143070	enhancer	E4130	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0072167	0.81458		ARRDC3	chr5	91368630	91383317	119362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3711
enhrx-171853	chrX	36867725	36867726	36849652	36849653	9553	hg38	N/A	N/A	N/A	Enhatls183888	enhancer	E4131	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12079	0.81464		H2AL1Q	chrX	36719828	36720573	85750	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1570
enhrx-102954	chr20	24965422	24965423	24984786	24984787	9554	hg38	N/A	enh62967	N/A	Enhatls110079	enhancer	E4132	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17679	0.81472		APMAP	chr20	24962924	24992751	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1382
enhrx-129829	chr4	181546974	181546975	180625821	180625822	9555	hg38	N/A	N/A	N/A	Enhatls138781	enhancer	E4133	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015619	0.81472		TENM3	chr4	182144689	182803024	1516238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7373
enhrx-145557	chr6	138985201	138985202	138664064	138664065	9556	hg38	N/A	enh23680	N/A	Enhatls155586	enhancer	E4134	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19215	0.81472		NHSL1	chr6	138422042	138692571	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7145
enhrx-133316	chr5	76616288	76616289	77320463	77320464	9557	hg38	N/A	enh105973	N/A	Enhatls142436	enhancer	E4135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19266	0.81472		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3107
enhrx-133316	chr5	76616288	76616289	77320463	77320464	9558	hg38	N/A	enh105973	N/A	Enhatls142436	enhancer	E4135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19266	0.81472		PDE8B	chr5	77210448	77428256	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3107
enhrx-128722	chr4	148079809	148079810	147158657	147158658	9559	hg38	N/A	enh100267	N/A	Enhatls137629	enhancer	E4136	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049999	0.81473		TTC29	chr4	146706616	146945882	210092	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6266
enhrx-113299	chr3	32470182	32470183	32428690	32428691	9560	hg38	N/A	enh7086	N/A	Enhatls121231	enhancer	E4137	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0023773	0.81473		CMTM7	chr3	32391697	32455528	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1428
enhrx-77847	chr18	44049644	44049645	46469681	46469682	9561	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	E4138	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17326	0.81509		ARK2C	chr18	46326808	46463140	1183	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1865
enhrx-31750	chr11	82351259	82351260	82640217	82640218	9562	hg38	N/A	N/A	N/A	Enhatls34498	enhancer	E4139	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045398	0.81531		FAM181B	chr11	82729939	82733864	83137	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6419
enhrx-32258	chr11	93929678	93929679	94196512	94196513	9563	hg38	N/A	enh29003	N/A	Enhatls35028	enhancer	E4140	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2036	0.81531		PANX1	chr11	94128840	94181968	9310	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6927
enhrx-2274	chr1	19727839	19727840	19401345	19401346	9564	hg38	N/A	enh98	N/A	Enhatls2532	enhancer	E4141	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.056394	0.81532		CAPZB	chr1	19338774	19485539	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2273
enhrx-94612	chr2	122113307	122113308	121355731	121355732	9565	hg38	N/A	enh33610	N/A	Enhatls101311	enhancer	E4142	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010757	0.81557		CLASP1	chr2	121337775	121649476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6538
enhrx-149998	chr7	54254312	54254313	54186619	54186620	9566	hg38	N/A	N/A	N/A	Enhatls160336	enhancer	E4143	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082973	0.81558		VSTM2A	chr7	54542324	54571080	341118	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2810
enhrx-40946	chr12	93935696	93935697	93541920	93541921	9567	hg38	N/A	enh43788	N/A	Enhatls44256	enhancer	E4144	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095918	0.81558		MRPL42	chr12	93467513	93516214	18606	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6256
enhrx-68277	chr17	10113669	10113670	10210352	10210353	9568	hg38	N/A	enh4254	N/A	Enhatls73281	enhancer	E4145	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12477	0.81558		GAS7	chr17	9910605	10198606	8023	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1546
enhrx-95965	chr2	157239829	157239830	156383317	156383318	9569	hg38	N/A	enh96989	N/A	Enhatls102733	enhancer	E4146	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12056	0.81598		NR4A2	chr2	156324436	156342348	36086	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7891
enhrx-61168	chr16	11678034	11678035	11584178	11584179	9570	hg38	N/A	N/A	N/A	Enhatls65754	enhancer	E4147	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0014809	0.81644		LITAF	chr16	11547721	11636381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1463
enhrx-69602	chr17	27073820	27073821	28746802	28746803	9571	hg38	N/A	N/A	N/A	Enhatls74705	enhancer	E4148	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065882	0.81687		TRAF4	chr17	28744010	28750956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2871
enhrx-56700	chr15	63250975	63250976	62958776	62958777	9572	hg38	N/A	enh64862	N/A	Enhatls61001	enhancer	E4149	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051445	0.81687		TPM1	chr15	63042631	63071915	70656	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3402
enhrx-6366	chr1	62707478	62707479	62241806	62241807	9573	hg38	N/A	enh11933	N/A	Enhatls6939	enhancer	E4150	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.027276	0.81687		KANK4	chr1	62236164	62319434	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6365
enhrx-145569	chr6	139139164	139139165	138818027	138818028	9574	hg38	N/A	enh23684	N/A	Enhatls155600	enhancer	E4151	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05098	0.81687		ECT2L	chr6	138795910	138904070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7157
enhrx-2110	chr1	18995440	18995441	18668946	18668947	9575	hg38	N/A	enh61803	N/A	Enhatls2358	enhancer	E4152	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087597	0.81687		PAX7	chr1	18630845	18748866	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2109
enhrx-42805	chr12	115911209	115911210	115473404	115473405	9576	hg38	N/A	enh51412	N/A	Enhatls46225	enhancer	E4153	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057962	0.81687		MED13L	chr12	115958575	116277693	481606	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8115
enhrx-112403	chr3	10800686	10800687	10759001	10759002	9577	hg38	hs3079	enh82424	N/A	Enhatls120274	enhancer	E4154	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029149	0.81687		ATP2B2	chr3	10324022	10708007	50208	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	532
enhrx-148633	chr7	26491903	26491904	26452283	26452284	9578	hg38	N/A	enh39989	N/A	Enhatls158849	enhancer	E4155	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071006	0.81687		SNX10	chr7	26291861	26374383	75707	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1445
enhrx-15144	chr1	209881649	209881650	209708304	209708305	9579	hg38	N/A	N/A	N/A	Enhatls16666	enhancer	E4156	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039473	0.81695		HSD11B1	chr1	209686177	209734949	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15143
enhrx-75471	chr17	78734669	78734670	80760869	80760870	9580	hg38	N/A	enh4636	N/A	Enhatls80995	enhancer	E4157	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.002858	0.81695		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-24022	chr10	116126995	116126996	114367236	114367237	9581	hg38	N/A	enh13534	N/A	Enhatls26371	enhancer	E4158	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017622	0.81776		AFAP1L2	chr10	114294823	114404756	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6457
enhrx-117167	chr3	106418196	106418197	106699349	106699350	9582	hg38	N/A	enh97328	N/A	Enhatls125388	enhancer	E4159	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11788	0.81776		CCDC54	chr3	107377438	107378635	676111	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5296
enhrx-42833	chr12	116701455	116701456	116263650	116263651	9583	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E4160	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.038144	0.81797		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-176353	chrX	131315479	131315480	132181451	132181452	9584	hg38	N/A	enh57458	N/A	Enhatls188576	enhancer	E4161	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015978	0.81799		RAP2C	chrX	132203023	132219480	15877	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6070
enhrx-147909	chr7	7361510	7361511	7321879	7321880	9585	hg38	N/A	enh23965	N/A	Enhatls158065	enhancer	E4162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071632	0.81843		COL28A1	chr7	7356567	7535873	22004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	721
enhrx-82311	chr19	16086858	16086859	15976048	15976049	9586	hg38	N/A	enh96829	N/A	Enhatls88255	enhancer	E4163	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.005888	0.8185		OR10H4	chr19	15944298	15950350	24909	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3281
enhrx-19091	chr10	29419262	29419263	29130333	29130334	9587	hg38	N/A	enh13086	N/A	Enhatls20864	enhancer	E4164	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015703	0.8185		LYZL1	chr10	29289060	29311232	156212	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-55614	chr15	48116628	48116629	47824431	47824432	9588	hg38	N/A	N/A	N/A	Enhatls59837	enhancer	E4165	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070686	0.8185		SEMA6D	chr15	47184100	47774228	50091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2316
enhrx-58803	chr15	86380469	86380470	85837238	85837239	9589	hg38	N/A	enh52138	N/A	Enhatls63327	enhancer	E4166	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24215	0.8185		KLHL25	chr15	85759325	85794925	40166	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-27586	chr11	30372072	30372073	30350525	30350526	9590	hg38	N/A	N/A	N/A	Enhatls30036	enhancer	E4167	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091936	0.81893		ARL14EP	chr11	30323103	30338223	10146	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2255
enhrx-92117	chr2	75072680	75072681	74845553	74845554	9591	hg38	N/A	enh5655	fant7581	Enhatls98694	enhancer	E4168	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1065	0.81893		HK2	chr2	74834126	74893359	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4043
enhrx-9282	chr1	115150046	115150047	114607425	114607426	9592	hg38	N/A	enh61891	N/A	Enhatls10020	enhancer	E4169	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082989	0.81893		DENND2C	chr1	114582847	114670111	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9281
enhrx-176652	chrX	137093826	137093827	138011667	138011668	9593	hg38	N/A	N/A	N/A	Enhatls188888	enhancer	E4170	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02078	0.81893		ZIC3	chrX	137566126	137577691	425813	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6369
enhrx-116050	chr3	58457250	58457251	58471523	58471524	9594	hg38	N/A	enh7254	fant12259	Enhatls124178	enhancer	E4171	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019802	0.81922		KCTD6	chr3	58492095	58502360	20298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4179
enhrx-131255	chr5	34480088	34480089	34479983	34479984	9595	hg38	N/A	enh22111	N/A	Enhatls140295	enhancer	E4172	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077345	0.81922		RAI14	chr5	34656327	34832612	162029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1046
enhrx-113454	chr3	35266588	35266589	35225096	35225097	9596	hg38	N/A	enh97257	N/A	Enhatls121396	enhancer	E4173	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048573	0.82003		ARPP21	chr3	35638944	35794496	411782	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1583
enhrx-78153	chr18	51736089	51736090	54209719	54209720	9597	hg38	N/A	enh32696	N/A	Enhatls83842	enhancer	E4174	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12473	0.82007		MBD2	chr18	54151605	54224669	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2171
enhrx-32490	chr11	101990980	101990981	102120249	102120250	9598	hg38	N/A	enh50973	N/A	Enhatls35277	enhancer	E4175	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074525	0.82042		YAP1	chr11	102110446	102233424	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7159
enhrx-106531	chr21	30204584	30204585	28832262	28832263	9599	hg38	N/A	enh48549	N/A	Enhatls113908	enhancer	E4176	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.051686	0.82042		N6AMT1	chr21	28872190	28885371	32518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	414
enhrx-44879	chr13	26545706	26545707	25971568	25971569	9600	hg38	N/A	enh47658	N/A	Enhatls48417	enhancer	E4177	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2119	0.82042		ATP8A2	chr13	25371973	26025851	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	501
enhrx-98392	chr2	198522495	198522496	197657771	197657772	9601	hg38	N/A	N/A	N/A	Enhatls105271	enhancer	E4178	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13118	0.82042		RFTN2	chr2	197568223	197676045	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10318
enhrx-163078	chr9	5843878	5843879	5843878	5843879	9602	hg38	N/A	enh25441	fant31778	Enhatls174151	enhancer	E4179	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055955	0.82085		ERMP1	chr9	5764152	5833117	10716	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	345
enhrx-134968	chr5	123143082	123143083	123807388	123807389	9603	hg38	N/A	enh8632	fant19684	Enhatls144170	enhancer	E4180	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069873	0.82133		CSNK1G3	chr5	123512176	123617049	190167	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4759
enhrx-44057	chr12	131322936	131322937	130838391	130838392	9604	hg38	N/A	N/A	N/A	Enhatls47569	enhancer	E4181	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12922	0.82133		STX2	chr12	130789599	130839250	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9367
enhrx-8959	chr1	111255835	111255836	110713213	110713214	9605	hg38	N/A	enh107399	N/A	Enhatls9662	enhancer	E4182	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0029607	0.82133		KCNA3	chr1	110672464	110674940	34904	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8958
enhrx-105366	chr20	56354616	56354617	57779560	57779561	9606	hg38	N/A	enh6562	N/A	Enhatls112686	enhancer	E4183	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21813	0.82134		PMEPA1	chr20	57648391	57711536	64494	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3794
enhrx-119980	chr3	149252803	149252804	149535016	149535017	9607	hg38	N/A	enh63216	N/A	Enhatls128361	enhancer	E4184	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1039	0.8218		WWTR1	chr3	149517234	149703273	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8109
enhrx-88719	chr2	16172060	16172061	16031938	16031939	9608	hg38	N/A	N/A	N/A	Enhatls95051	enhancer	E4185	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070048	0.8218		MYCN	chr2	15940549	15947007	77107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	645
enhrx-26704	chr11	12270189	12270190	12248642	12248643	9609	hg38	N/A	N/A	N/A	Enhatls29121	enhancer	E4186	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041905	0.8218		MICAL2	chr11	12094007	12358479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1373
enhrx-26289	chr11	7560194	7560195	7538963	7538964	9610	hg38	N/A	N/A	N/A	Enhatls28653	enhancer	E4187	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013113	0.8218		PPFIBP2	chr11	7513297	7657078	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	958
enhrx-45528	chr13	39330071	39330072	38755934	38755935	9611	hg38	N/A	enh68384	N/A	Enhatls49129	enhancer	E4188	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083682	0.8218		FREM2	chr13	38687076	38887131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1150
enhrx-102717	chr20	19756434	19756435	19775790	19775791	9612	hg38	N/A	enh6310	N/A	Enhatls109831	enhancer	E4189	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11206	0.8218		RIN2	chr20	19758257	20002457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1145
enhrx-158373	chr8	40387648	40387649	40530129	40530130	9613	hg38	N/A	N/A	N/A	Enhatls169206	enhancer	E4190	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12565	0.8225		ZMAT4	chr8	40530589	40897833	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-88801	chr2	19751842	19751843	19552081	19552082	9614	hg38	N/A	N/A	N/A	Enhatls95137	enhancer	E4191	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19044	0.82321		OSR1	chr2	19351484	19358623	187292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	727
enhrx-23588	chr10	106048355	106048356	104288597	104288598	9615	hg38	N/A	N/A	N/A	Enhatls25895	enhancer	E4192	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035497	0.82321		GSTO2	chr10	104268872	104304950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6023
enhrx-132945	chr5	71228673	71228674	71932846	71932847	9616	hg38	N/A	enh37943	N/A	Enhatls142059	enhancer	E4193	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19906	0.82322		MAP1B	chr5	72107233	72209565	171726	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2736
enhrx-134074	chr5	95034215	95034216	95698511	95698512	9617	hg38	N/A	N/A	N/A	Enhatls143229	enhancer	E4194	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041562	0.82322		SPATA9	chr5	95658314	95682991	5026	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3865
enhrx-160110	chr8	91900058	91900059	90887830	90887831	9618	hg38	N/A	enh25118	fant30119	Enhatls171026	enhancer	E4195	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054711	0.82322		NECAB1	chr8	90791774	90959393	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3901
enhrx-148251	chr7	18218081	18218082	18178458	18178459	9619	hg38	N/A	enh49222	N/A	Enhatls158429	enhancer	E4196	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042229	0.82383		HDAC9	chr7	18086948	19002416	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1063
enhrx-3782	chr1	32775765	32775766	32310164	32310165	9620	hg38	N/A	enh210	N/A	Enhatls4188	enhancer	E4197	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033732	0.82383		HDAC1	chr1	32292082	32333626	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3781
enhrx-138685	chr6	6565575	6565576	6565342	6565343	9621	hg38	N/A	enh88993	N/A	Enhatls148266	enhancer	E4198	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064144	0.82394		LY86	chr6	6588107	6654983	20726	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	273
enhrx-45174	chr13	32708569	32708570	32134432	32134433	9622	hg38	N/A	N/A	N/A	Enhatls48748	enhancer	E4199	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010868	0.82394		FRY	chr13	31846712	32299125	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	796
enhrx-148456	chr7	22707740	22707741	22668121	22668122	9623	hg38	N/A	enh24027	N/A	N/A	enhancer	E4200	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11921	0.82434		STEAP1B	chr7	22419443	22632925	32417	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1268
enhrx-168015	chr9	126082445	126082446	123320166	123320167	9624	hg38	N/A	N/A	N/A	Enhatls179828	enhancer	E4201	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16265	0.82435		CRB2	chr9	123356169	123378753	35824	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5282
enhrx-13707	chr1	191397024	191397025	191427894	191427895	9625	hg38	N/A	enh95944	N/A	Enhatls15129	enhancer	E4202	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062523	0.82468		RGS18	chr1	192158461	192185815	728637	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13706
enhrx-173008	chrX	53692466	53692467	53665512	53665513	9626	hg38	N/A	enh98329	N/A	Enhatls185203	enhancer	E4203	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056897	0.82468		HUWE1	chrX	53532095	53686719	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2725
enhrx-65007	chr16	68824299	68824300	68790396	68790397	9627	hg38	N/A	enh16745	N/A	Enhatls69769	enhancer	E4204	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12611	0.82513		CDH1	chr16	68737291	68835537	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5302
enhrx-73146	chr17	57444373	57444374	59367012	59367013	9628	hg38	N/A	enh17258	N/A	Enhatls78526	enhancer	E4205	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1577	0.82576		YPEL2	chr17	59331654	59401729	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6415
enhrx-156420	chr8	5424715	5424716	5567193	5567194	9629	hg38	N/A	N/A	N/A	Enhatls167089	enhancer	E4206	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10591	0.82576		CSMD1	chr8	2935352	4994972	511659	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	211
enhrx-154495	chr7	134651620	134651621	134966869	134966870	9630	hg38	N/A	N/A	N/A	Enhatls165105	enhancer	E4207	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069504	0.82576		CALD1	chr7	134744251	134970729	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7307
enhrx-121837	chr3	188694397	188694398	188976608	188976609	9631	hg38	N/A	enh65798	N/A	Enhatls130390	enhancer	E4208	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12659	0.82576		TPRG1	chr3	188947213	189325304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9966
enhrx-124828	chr4	54538142	54538143	53671975	53671976	9632	hg38	N/A	enh36599	N/A	Enhatls133562	enhancer	E4209	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10928	0.82576		LNX1	chr4	53459300	53701405	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2372
enhrx-137694	chr5	173734865	173734866	174307862	174307863	9633	hg38	N/A	N/A	N/A	Enhatls147169	enhancer	E4210	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00052236	0.82581		NSG2	chr5	174045705	174243501	62212	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7485
enhrx-31677	chr11	78023055	78023056	78312009	78312010	9634	hg38	N/A	enh14133	N/A	Enhatls34423	enhancer	E4211	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056843	0.82592		GAB2	chr11	78215292	78418348	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6346
enhrx-30644	chr11	67867282	67867283	68099815	68099816	9635	hg38	N/A	enh28842	N/A	Enhatls33315	enhancer	E4212	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0098896	0.82592		CHKA	chr11	68052858	68121444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5313
enhrx-143954	chr6	105839758	105839759	105391883	105391884	9636	hg38	N/A	N/A	N/A	Enhatls153830	enhancer	E4213	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23196	0.82592		PREP	chr6	105273217	105454062	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5542
enhrx-59099	chr15	90698499	90698500	90155267	90155268	9637	hg38	N/A	enh16414	N/A	Enhatls63639	enhancer	E4214	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17937	0.82691		SEMA4B	chr15	90160603	90229670	2301	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5801
enhrx-50787	chr14	69274194	69274195	68807477	68807478	9638	hg38	N/A	enh3302	fant46491	Enhatls54772	enhancer	E4215	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.010567	0.82706		ZFP36L1	chr14	68787661	68796253	11163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2744
enhrx-29089	chr11	60150074	60150075	60382601	60382602	9639	hg38	N/A	N/A	N/A	Enhatls31609	enhancer	E4216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0064209	0.82762		MS4A7	chr11	60378484	60395951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-29089	chr11	60150074	60150075	60382601	60382602	9640	hg38	N/A	N/A	N/A	Enhatls31609	enhancer	E4216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0064209	0.82762		MS4A14	chr11	60378529	60417756	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-107092	chr21	37985584	37985585	36613286	36613287	9641	hg38	N/A	enh82355	N/A	Enhatls114513	enhancer	E4217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057653	0.82763		CLDN14	chr21	36460620	36576569	34579	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	975
enhrx-113055	chr3	23998376	23998377	23956885	23956886	9642	hg38	N/A	enh86459	N/A	Enhatls120967	enhancer	E4218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061887	0.82763		NR1D2	chr3	23945285	23980617	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1184
enhrx-49108	chr14	35823244	35823245	35354038	35354039	9643	hg38	N/A	enh15583	N/A	Enhatls53011	enhancer	E4219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1589	0.82792		PSMA6	chr14	35278632	35317493	34960	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1065
enhrx-136310	chr5	145943804	145943805	146564241	146564242	9644	hg38	N/A	enh22682	N/A	Enhatls145626	enhancer	E4220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040674	0.82828		PPP2R2B	chr5	146580741	147081491	12730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6101
enhrx-21995	chr10	91226560	91226561	89466803	89466804	9645	hg38	N/A	enh13381	N/A	Enhatls24201	enhancer	E4221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11387	0.82909		SLC16A12	chr10	89430298	89556641	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4430
enhrx-118184	chr3	122678400	122678401	122959553	122959554	9646	hg38	N/A	N/A	N/A	Enhatls126455	enhancer	E4222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11311	0.82972		SEMA5B	chr3	122909081	123027878	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6313
enhrx-156955	chr8	17471967	17471968	17614458	17614459	9647	hg38	N/A	enh24775	N/A	Enhatls167670	enhancer	E4223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063899	0.82972		PDGFRL	chr8	17576432	17643144	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	746
enhrx-77240	chr18	26583267	26583268	29003303	29003304	9648	hg38	N/A	enh96795	N/A	Enhatls82891	enhancer	E4224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19018	0.82987		CDH2	chr18	27932878	28177946	822936	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1258
enhrx-133087	chr5	73509943	73509944	74214118	74214119	9649	hg38	N/A	enh97688	N/A	Enhatls142204	enhancer	E4225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17275	0.82987		ARHGEF28	chr5	73626157	73941993	270008	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2878
enhrx-95180	chr2	134644655	134644656	133887084	133887085	9650	hg38	N/A	enh18875	N/A	Enhatls101913	enhancer	E4226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044303	0.82987		MGAT5	chr2	134120181	134454621	230278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7106
enhrx-9571	chr1	118659689	118659690	118117066	118117067	9651	hg38	N/A	enh12206	N/A	Enhatls10340	enhancer	E4227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18079	0.82987		SPAG17	chr1	117953589	118185228	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9570
enhrx-75252	chr17	77480048	77480049	79483966	79483967	9652	hg38	N/A	N/A	N/A	Enhatls80790	enhancer	E4228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14315	0.82987		RBFOX3	chr17	79089344	79611051	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8521
enhrx-120640	chr3	167466296	167466297	167748508	167748509	9653	hg38	N/A	enh61103	N/A	Enhatls129077	enhancer	E4229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17206	0.82987		SERPINI1	chr3	167735242	167825569	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8769
enhrx-41903	chr12	107881268	107881269	107487491	107487492	9654	hg38	N/A	enh51390	N/A	Enhatls45275	enhancer	E4230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0063602	0.82987		ABTB3	chr12	107318420	107659642	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7213
enhrx-143833	chr6	100930753	100930754	100482877	100482878	9655	hg38	N/A	enh97890	N/A	Enhatls153711	enhancer	E4231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15472	0.82987		SIM1	chr6	100385008	100464921	15929	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5421
enhrx-70143	chr17	33243336	33243337	34916317	34916318	9656	hg38	N/A	enh96742	N/A	Enhatls75275	enhancer	E4232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20514	0.82987		CCT6B	chr17	34927858	34981078	8163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3412
enhrx-49957	chr14	56688294	56688295	56221576	56221577	9657	hg38	N/A	enh47762	N/A	Enhatls53911	enhancer	E4233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13037	0.82987		PELI2	chr14	56117813	56301524	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1914
enhrx-44686	chr13	24723073	24723074	24148934	24148935	9658	hg38	N/A	enh15150	fant43896	Enhatls48218	enhancer	E4234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16411	0.82987		SPATA13	chr13	23979804	24307074	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	308
enhrx-45832	chr13	45022711	45022712	44448575	44448576	9659	hg38	N/A	enh51531	N/A	Enhatls49468	enhancer	E4235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23377	0.82987		TSC22D1	chr13	44432142	44577147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1454
enhrx-165522	chr9	84150608	84150609	81535693	81535694	9660	hg38	N/A	enh25642	N/A	Enhatls177133	enhancer	E4236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11501	0.82987		TLE1	chr9	81583682	81689547	42523	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-123677	chr4	17755292	17755293	17753669	17753670	9661	hg38	N/A	N/A	N/A	Enhatls132359	enhancer	E4237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1231	0.82987		FAM184B	chr4	17629305	17781621	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1221
enhrx-18149	chr10	12910404	12910405	12868404	12868405	9662	hg38	N/A	N/A	N/A	Enhatls19837	enhancer	E4238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055579	0.82987		CAMK1D	chr10	12349546	12835545	16234	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	584
enhrx-107006	chr21	37326083	37326084	35953785	35953786	9663	hg38	N/A	enh19934	N/A	Enhatls114418	enhancer	E4239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11563	0.82987		RUNX1	chr21	34787800	36004667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	889
enhrx-28145	chr11	45000645	45000646	44979094	44979095	9664	hg38	N/A	enh50812	fant38493	Enhatls30637	enhancer	E4240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26566	0.82987		TP53I11	chr11	44932347	44951306	27528	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2814
enhrx-170612	chrX	4574618	4574619	4656577	4656578	9665	hg38	N/A	enh85537	N/A	Enhatls182569	enhancer	E4241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013627	0.82987		PRKX	chrX	3604339	3713649	940196	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	329
enhrx-111501	chr22	47100883	47100884	46704986	46704987	9666	hg38	N/A	N/A	N/A	Enhatls119322	enhancer	E4242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14168	0.82987		CERK	chr22	46684409	46738252	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3332
enhrx-2468	chr1	21595151	21595152	21268658	21268659	9667	hg38	N/A	enh26575	N/A	Enhatls2739	enhancer	E4243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0010261	0.83002		ECE1	chr1	21217246	21345572	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2467
enhrx-93436	chr2	101574552	101574553	100958090	100958091	9668	hg38	N/A	enh33521	N/A	Enhatls100069	enhancer	E4244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037512	0.83002		NPAS2	chr2	100820138	100996829	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5362
enhrx-159177	chr8	63920629	63920630	63008070	63008071	9669	hg38	N/A	enh10372	N/A	Enhatls170033	enhancer	E4245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16999	0.83002		NKAIN3	chr8	62248590	63014000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2968
enhrx-20403	chr10	62608621	62608622	60848863	60848864	9670	hg38	N/A	enh43305	N/A	Enhatls22475	enhancer	E4246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10137	0.83002		RHOBTB1	chr10	60869437	61001440	18481	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2838
enhrx-157335	chr8	22596848	22596849	22739335	22739336	9671	hg38	N/A	enh24829	N/A	Enhatls168083	enhancer	E4247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095693	0.83002		PEBP4	chr8	22713250	23000000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1126
enhrx-89318	chr2	27205459	27205460	26982591	26982592	9672	hg38	N/A	enh33152	N/A	Enhatls95674	enhancer	E4248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0098977	0.83002		MAPRE3	chr2	26970636	27027219	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1244
enhrx-141417	chr6	43065382	43065383	43097644	43097645	9673	hg38	N/A	enh23249	N/A	Enhatls151179	enhancer	E4249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10227	0.83002		PTK7	chr6	43076306	43161719	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3005
enhrx-138468	chr6	1291229	1291230	1290994	1290995	9674	hg38	N/A	N/A	N/A	Enhatls148030	enhancer	E4250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098915	0.83002		FOXQ1	chr6	1312097	1314758	18248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	56
enhrx-56651	chr15	62747731	62747732	62455532	62455533	9675	hg38	N/A	enh31439	N/A	Enhatls60946	enhancer	E4251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18623	0.83002		TLN2	chr15	62390549	62844631	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3353
enhrx-80365	chr19	6259448	6259449	6259437	6259438	9676	hg38	N/A	enh17889	N/A	Enhatls86220	enhancer	E4252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075663	0.83101		MLLT1	chr19	6210380	6279975	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1335
enhrx-143123	chr6	83661354	83661355	82951635	82951636	9677	hg38	N/A	enh9218	N/A	Enhatls152984	enhancer	E4253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054184	0.83195		UBE3D	chr6	82892389	83065841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4711
enhrx-135960	chr5	139639216	139639217	140259631	140259632	9678	hg38	N/A	enh22635	fant20030	Enhatls145249	enhancer	E4254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058594	0.8321		PFDN1	chr5	140245034	140303113	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5751
enhrx-168815	chr9	132536039	132536040	129773760	129773761	9679	hg38	N/A	enh26063	fant33869	Enhatls180700	enhancer	E4255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07655	0.8321		PTGES	chr9	129738348	129753042	20565	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6082
enhrx-56408	chr15	58813995	58813996	58521796	58521797	9680	hg38	N/A	enh16178	N/A	Enhatls60690	enhancer	E4256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069647	0.8321		LIPC	chr15	58410568	58569844	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3110
enhrx-38990	chr12	55059901	55059902	54666117	54666118	9681	hg38	N/A	N/A	N/A	Enhatls42178	enhancer	E4257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041349	0.8321		DCD	chr12	54644588	54648493	12419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4300
enhrx-146398	chr6	157041126	157041127	156719992	156719993	9682	hg38	N/A	enh23805	N/A	Enhatls156480	enhancer	E4258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065475	0.8321		ARID1B	chr6	156776019	157210779	52379	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7986
enhrx-102940	chr20	24630862	24630863	24650226	24650227	9683	hg38	N/A	enh6327	N/A	Enhatls110065	enhancer	E4259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11233	0.8321		SYNDIG1	chr20	24469628	24666616	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1368
enhrx-18698	chr10	22375835	22375836	22086906	22086907	9684	hg38	N/A	enh13048	N/A	Enhatls20454	enhancer	E4260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085477	0.8321		DNAJC1	chr10	21756547	22003730	80633	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1133
enhrx-115674	chr3	53569652	53569653	53535625	53535626	9685	hg38	N/A	enh100023	N/A	Enhatls123759	enhancer	E4261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058407	0.8321		CACNA1D	chr3	53328962	53813733	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3803
enhrx-24043	chr10	116474410	116474411	114714651	114714652	9686	hg38	N/A	enh13541	N/A	Enhatls26396	enhancer	E4262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077099	0.83215		ABLIM1	chr10	114431111	114768061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6478
enhrx-139171	chr6	18915260	18915261	18915029	18915030	9687	hg38	N/A	N/A	N/A	Enhatls148782	enhancer	E4263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.065101	0.83215		RNF144B	chr6	18387349	18468870	427215	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	759
enhrx-28900	chr11	57568213	57568214	57800741	57800742	9688	hg38	N/A	enh1786	N/A	Enhatls31423	enhancer	E4264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10926	0.83215		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3569
enhrx-50989	chr14	72871040	72871041	72404332	72404333	9689	hg38	N/A	enh15752	N/A	Enhatls54990	enhancer	E4265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092641	0.83219		RGS6	chr14	71932428	72566530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2946
enhrx-114587	chr3	47822110	47822111	47780620	47780621	9690	hg38	N/A	N/A	N/A	Enhatls122622	enhancer	E4266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19658	0.83219		SMARCC1	chr3	47585268	47781893	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2716
enhrx-128137	chr4	125675240	125675241	124754085	124754086	9691	hg38	N/A	enh83309	N/A	Enhatls137012	enhancer	E4267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040483	0.83225		ANKRD50	chr4	124664047	124712732	40186	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5681
enhrx-20914	chr10	72311985	72311986	70552229	70552230	9692	hg38	N/A	enh13281	fant36003	Enhatls23029	enhancer	E4268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0046601	0.8329		PALD1	chr10	70478766	70668740	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3349
enhrx-2345	chr1	20577002	20577003	20250509	20250510	9693	hg38	N/A	enh78970	N/A	Enhatls2602	enhancer	E4269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097858	0.8329		VWA5B1	chr1	20290874	20359518	37633	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2344
enhrx-115355	chr3	52251146	52251147	52217130	52217131	9694	hg38	N/A	enh7218	N/A	Enhatls123413	enhancer	E4270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21316	0.8329		ALAS1	chr3	52198085	52214327	223	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3484
enhrx-128114	chr4	124234519	124234520	123313364	123313365	9695	hg38	N/A	N/A	N/A	Enhatls136988	enhancer	E4271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011986	0.83299		AFG2A	chr4	122923069	123319433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5658
enhrx-119344	chr3	137228725	137228726	137509883	137509884	9696	hg38	N/A	N/A	N/A	Enhatls127706	enhancer	E4272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076378	0.83299		SOX14	chr3	137764314	137766334	183698	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7473
enhrx-90919	chr2	55391185	55391186	55164049	55164050	9697	hg38	N/A	enh5542	N/A	Enhatls97424	enhancer	E4273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12431	0.83299		CLHC1	chr2	55172546	55232563	6890	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-154962	chr7	140692377	140692378	140992577	140992578	9698	hg38	N/A	enh98072	N/A	Enhatls165591	enhancer	E4274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099369	0.83299		MRPS33	chr7	141002609	141015228	7915	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7774
enhrx-171616	chrX	28319516	28319517	28301399	28301400	9699	hg38	N/A	N/A	N/A	Enhatls183644	enhancer	E4275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03614	0.83299		DCAF8L1	chrX	27977991	27981449	245114	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1333
enhrx-73199	chr17	57892259	57892260	59814898	59814899	9700	hg38	N/A	N/A	N/A	Enhatls78581	enhancer	E4276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095428	0.83299		VMP1	chr17	59707516	59842255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6468
enhrx-165522	chr9	83839514	83839515	81224599	81224600	9701	hg38	N/A	enh25636	N/A	Enhatls177133	enhancer	E4277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039431	0.83299		TLE1	chr9	81583682	81689547	355823	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-32420	chr11	100773714	100773715	100902983	100902984	9702	hg38	N/A	N/A	N/A	Enhatls35204	enhancer	E4278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14829	0.83362		ARHGAP42	chr11	100687287	100993941	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7089
enhrx-13188	chr1	181088603	181088604	181119467	181119468	9703	hg38	N/A	enh12430	N/A	Enhatls14557	enhancer	E4279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02427	0.83362		IER5	chr1	181088699	181092900	19870	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13187
enhrx-73779	chr17	63071089	63071090	65074971	65074972	9704	hg38	N/A	enh17304	N/A	Enhatls79203	enhancer	E4280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040674	0.83392		RGS9	chr17	65100985	65227703	5230	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7048
enhrx-21054	chr10	73730160	73730161	71970402	71970403	9705	hg38	N/A	enh13294	N/A	Enhatls23175	enhancer	E4281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0041167	0.83392		CHST3	chr10	71964394	72013558	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3489
enhrx-33855	chr11	120130865	120130866	120260156	120260157	9706	hg38	N/A	enh2049	N/A	Enhatls36732	enhancer	E4282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.10734	0.83394		POU2F3	chr11	120236639	120319945	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8524
enhrx-149379	chr7	42685733	42685734	42646134	42646135	9707	hg38	N/A	N/A	N/A	Enhatls159665	enhancer	E4283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12929	0.83394		C7orf25	chr7	42909272	42912305	250147	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2191
enhrx-113457	chr3	35550108	35550109	35508616	35508617	9708	hg38	N/A	N/A	N/A	Enhatls121399	enhancer	E4284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089755	0.83394		ARPP21	chr3	35638944	35794496	116992	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1586
enhrx-95928	chr2	153587616	153587617	152731102	152731103	9709	hg38	N/A	N/A	N/A	Enhatls102692	enhancer	E4285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33322	0.83394		ARL6IP6	chr2	152717646	152762396	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7854
enhrx-103530	chr20	32938158	32938159	34350352	34350353	9710	hg38	N/A	enh6365	N/A	Enhatls110693	enhancer	E4286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.034776	0.83394		ITCH	chr20	34363234	34511773	10746	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1958
enhrx-46638	chr13	74610757	74610758	74036620	74036621	9711	hg38	N/A	enh2938	N/A	Enhatls50357	enhancer	E4287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15287	0.83397		KLF12	chr13	73686088	74134404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2260
enhrx-4231	chr1	36825693	36825694	36360092	36360093	9712	hg38	N/A	N/A	fant1223	Enhatls4665	enhancer	E4288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066707	0.83398		STK40	chr1	36339623	36385924	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4230
enhrx-109040	chr22	24593934	24593935	24197966	24197967	9713	hg38	N/A	enh20089	N/A	Enhatls116676	enhancer	E4289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052885	0.83398		SUSD2	chr22	24181486	24189106	4572	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	871
enhrx-167268	chr9	114662622	114662623	111900342	111900343	9714	hg38	N/A	enh42198	N/A	Enhatls179015	enhancer	E4290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019268	0.83409		UGCG	chr9	111896813	111935369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4535
enhrx-8099	chr1	95473482	95473483	95007926	95007927	9715	hg38	N/A	enh26979	N/A	Enhatls8775	enhancer	E4291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0013429	0.83409		ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8098
enhrx-6228	chr1	59351185	59351186	58885513	58885514	9716	hg38	N/A	enh11916	fant1758	Enhatls6778	enhancer	E4292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10891	0.83409		JUN	chr1	58780790	58784047	100969	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6227
enhrx-106748	chr21	33721179	33721180	32348870	32348871	9717	hg38	N/A	N/A	N/A	Enhatls114137	enhancer	E4293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011457	0.83409		URB1	chr21	32311017	32393012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	631
enhrx-129393	chr4	166354835	166354836	165433683	165433684	9718	hg38	N/A	enh71525	N/A	Enhatls138316	enhancer	E4294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13298	0.83549		CPE	chr4	165361193	165498547	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6937
enhrx-13716	chr1	192319864	192319865	192350734	192350735	9719	hg38	N/A	N/A	N/A	Enhatls15138	enhancer	E4295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13991	0.83549		RGS21	chr1	192316991	192367285	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13715
enhrx-128114	chr4	124224003	124224004	123302848	123302849	9720	hg38	N/A	enh37000	N/A	Enhatls136988	enhancer	E4296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24433	0.83549		AFG2A	chr4	122923069	123319433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5658
enhrx-117636	chr3	113454418	113454419	113735571	113735572	9721	hg38	N/A	enh7452	N/A	Enhatls125902	enhancer	E4297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17022	0.83549		NAA50	chr3	113716457	113746300	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5765
enhrx-134772	chr5	118357404	118357405	119021709	119021710	9722	hg38	N/A	enh61293	N/A	Enhatls143968	enhancer	E4298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050945	0.83549		DTWD2	chr5	118836073	118988547	25398	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4563
enhrx-83595	chr19	34071381	34071382	33580475	33580476	9723	hg38	N/A	N/A	N/A	Enhatls89653	enhancer	E4299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066903	0.83549		CHST8	chr19	33621952	33773509	41204	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4565
enhrx-141967	chr6	50810281	50810282	50842568	50842569	9724	hg38	N/A	enh23296	N/A	Enhatls151773	enhancer	E4300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07693	0.83549		TFAP2B	chr6	50818722	50847619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3555
enhrx-143956	chr6	106076529	106076530	105628654	105628655	9725	hg38	N/A	enh55914	N/A	Enhatls153832	enhancer	E4301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021927	0.83549		PREP	chr6	105273217	105454062	167160	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5544
enhrx-153088	chr7	105575261	105575262	105934815	105934816	9726	hg38	N/A	enh46445	N/A	Enhatls163606	enhancer	E4302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12696	0.83549		CDHR3	chr7	105963258	106036432	20910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5900
enhrx-22921	chr10	101327914	101327915	99568157	99568158	9727	hg38	N/A	enh67597	N/A	Enhatls25173	enhancer	E4303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1127	0.83549		NKX2-3	chr10	99532941	99536524	30745	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5356
enhrx-15110	chr1	209719889	209719890	209546544	209546545	9728	hg38	N/A	enh50167	N/A	Enhatls16629	enhancer	E4304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087046	0.83549		CAMK1G	chr1	209583713	209613939	31424	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15109
enhrx-84534	chr19	39651219	39651220	39160579	39160580	9729	hg38	N/A	enh18061	N/A	Enhatls90616	enhancer	E4305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04871	0.8359		PAK4	chr19	39125769	39182816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5504
enhrx-167587	chr9	117670503	117670504	114908223	114908224	9730	hg38	N/A	enh10925	fant33396	Enhatls179357	enhancer	E4306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051731	0.8359		TNFSF8	chr9	114893342	114930595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4854
enhrx-158396	chr8	41417139	41417140	41559620	41559621	9731	hg38	N/A	enh98106	N/A	Enhatls169229	enhancer	E4307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047804	0.8359		GINS4	chr8	41529220	41545030	12397	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2187
enhrx-16206	chr1	228243441	228243442	228055740	228055741	9732	hg38	N/A	N/A	N/A	Enhatls17795	enhancer	E4308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14892	0.8359		WNT3A	chr1	228006997	228061271	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16205
enhrx-7444	chr1	86065547	86065548	85599864	85599865	9733	hg38	N/A	N/A	N/A	Enhatls8069	enhancer	E4309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035008	0.8359		CCN1	chr1	85580760	85583950	15383	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7443
enhrx-39662	chr12	61054160	61054161	60660379	60660380	9734	hg38	N/A	N/A	N/A	Enhatls42880	enhancer	E4310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049016	0.8359		SLC16A7	chr12	59596028	59789855	760271	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4972
enhrx-136476	chr5	148304715	148304716	148925152	148925153	9735	hg38	N/A	N/A	N/A	Enhatls145798	enhancer	E4311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06634	0.8359		SH3TC2	chr5	148982149	149063089	55968	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6267
enhrx-68837	chr17	17442145	17442146	17538831	17538832	9736	hg38	hs1917	enh52438	N/A	Enhatls73862	enhancer	E4312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02477	0.83611		PEMT	chr17	17505562	17591708	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2106
enhrx-57404	chr15	70384459	70384460	70092120	70092121	9737	hg38	N/A	enh16280	N/A	Enhatls61769	enhancer	E4313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02129	0.83611		TLE3	chr15	70047789	70098176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4106
enhrx-91030	chr2	56394752	56394753	56167617	56167618	9738	hg38	N/A	enh18576	N/A	Enhatls97540	enhancer	E4314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089805	0.83611		CCDC85A	chr2	56183989	56386172	11210	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2956
enhrx-85920	chr19	47394174	47394175	46890917	46890918	9739	hg38	N/A	enh5182	N/A	Enhatls92094	enhancer	E4315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18964	0.83613		ARHGAP35	chr19	46860996	47005077	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6890
enhrx-30521	chr11	67113590	67113591	67346119	67346120	9740	hg38	N/A	enh1847	N/A	Enhatls33151	enhancer	E4316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15908	0.83614		POLD4	chr11	67350771	67356972	13	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5190
enhrx-148127	chr7	15081826	15081827	15042201	15042202	9741	hg38	N/A	enh84530	N/A	Enhatls158298	enhancer	E4317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023519	0.83691		DGKB	chr7	14145048	14974777	64084	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	939
enhrx-130971	chr5	16787578	16787579	16787469	16787470	9742	hg38	N/A	enh45828	N/A	Enhatls139993	enhancer	E4318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096143	0.83746		MYO10	chr5	16661906	16936288	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	762
enhrx-120870	chr3	172003274	172003275	172285484	172285485	9743	hg38	N/A	enh54500	N/A	Enhatls129335	enhancer	E4319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054216	0.83746		FNDC3B	chr3	172039577	172401669	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8999
enhrx-119983	chr3	149420030	149420031	149702243	149702244	9744	hg38	N/A	N/A	N/A	Enhatls128365	enhancer	E4320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14962	0.83749		WWTR1	chr3	149517234	149703273	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8112
enhrx-165773	chr9	89575231	89575232	86960316	86960317	9745	hg38	N/A	enh25676	N/A	Enhatls177400	enhancer	E4321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033946	0.83749		GAS1	chr9	86944361	86947506	8825	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3040
enhrx-17810	chr10	5698718	5698719	5656755	5656756	9746	hg38	N/A	enh47331	N/A	Enhatls19461	enhancer	E4322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12925	0.83749		ASB13	chr10	5638866	5666595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	245
enhrx-46264	chr13	52210683	52210684	51636547	51636548	9747	hg38	N/A	enh15345	N/A	Enhatls49953	enhancer	E4323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16045	0.83749		WDFY2	chr13	51584454	51767709	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1886
enhrx-34041	chr11	123007690	123007691	123136982	123136983	9748	hg38	N/A	enh14347	N/A	Enhatls36949	enhancer	E4324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030765	0.83749		CLMP	chr11	123069871	123195248	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8710
enhrx-50831	chr14	69809737	69809738	69343020	69343021	9749	hg38	N/A	N/A	N/A	Enhatls54823	enhancer	E4325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08873	0.83749		GALNT16	chr14	69259963	69357033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2788
enhrx-18477	chr10	17507940	17507941	17465941	17465942	9750	hg38	N/A	N/A	N/A	Enhatls20179	enhancer	E4326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11438	0.83772		ST8SIA6	chr10	17315420	17454595	4667	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	912
enhrx-77205	chr18	24280032	24280033	26700068	26700069	9751	hg38	N/A	enh48115	N/A	Enhatls82856	enhancer	E4327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021157	0.83772		KCTD1	chr18	26454909	26657401	41421	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1223
enhrx-149376	chr7	42131468	42131469	42091869	42091870	9752	hg38	"hs2731,hs2731,hs2731"	enh24152	N/A	Enhatls159662	enhancer	E4328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022927	0.83851		GLI3	chr7	41960948	42264100	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2188
enhrx-167267	chr9	114639960	114639961	111877680	111877681	9753	hg38	N/A	enh60000	N/A	Enhatls179014	enhancer	E4329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039368	0.8388		UGCG	chr9	111896813	111935369	17059	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4534
enhrx-24645	chr10	124779737	124779738	123020221	123020222	9754	hg38	N/A	enh67658	N/A	Enhatls27016	enhancer	E4330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095775	0.8388		ACADSB	chr10	123008978	123058290	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7080
enhrx-60243	chr16	2085854	2085855	2035853	2035854	9755	hg38	N/A	N/A	N/A	Enhatls64792	enhancer	E4331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11544	0.83931		NHERF2	chr16	2025355	2039026	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	538
enhrx-33817	chr11	119232074	119232075	119361364	119361365	9756	hg38	N/A	enh2042	N/A	Enhatls36689	enhancer	E4332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0047752	0.83931		USP2	chr11	119355214	119381711	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8486
enhrx-28896	chr11	57549246	57549247	57781774	57781775	9757	hg38	N/A	N/A	N/A	Enhatls31418	enhancer	E4333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12027	0.8395		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-148157	chr7	16397775	16397776	16358150	16358151	9758	hg38	N/A	enh39910	N/A	Enhatls158329	enhancer	E4334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037856	0.8396		CRPPA	chr7	16087524	16502504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	969
enhrx-149971	chr7	50839113	50839114	50771416	50771417	9759	hg38	N/A	enh66415	N/A	Enhatls160307	enhancer	E4335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046642	0.8396		GRB10	chr7	50590062	50793462	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2783
enhrx-105982	chr20	62309946	62309947	63678593	63678594	9760	hg38	N/A	N/A	N/A	Enhatls113329	enhancer	E4336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0028314	0.8396		RTEL1	chr20	63657809	63696253	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4410
enhrx-90307	chr2	39952146	39952147	39725006	39725007	9761	hg38	N/A	enh33245	N/A	Enhatls96740	enhancer	E4337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047908	0.8396		TMEM178A	chr2	39665916	39717963	2943	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2233
enhrx-120741	chr3	169764546	169764547	170046758	170046759	9762	hg38	N/A	enh7681	N/A	Enhatls129194	enhancer	E4338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11233	0.8396		GPR160	chr3	170037994	170085392	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8870
enhrx-51695	chr14	81660776	81660777	81194432	81194433	9763	hg38	N/A	N/A	N/A	Enhatls55750	enhancer	E4339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073105	0.83997		GTF2A1	chr14	81175451	81221231	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3652
enhrx-57757	chr15	74680629	74680630	74388289	74388290	9764	hg38	N/A	enh3715	N/A	Enhatls62135	enhancer	E4340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14876	0.84069		CYP11A1	chr15	74337758	74367646	16555	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4459
enhrx-47210	chr13	98945527	98945528	98293273	98293274	9765	hg38	N/A	enh88063	N/A	Enhatls50976	enhancer	E4341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074349	0.84079		FARP1	chr13	98142561	98455176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2832
enhrx-72717	chr17	48992702	48992703	50915341	50915342	9766	hg38	N/A	enh4464	N/A	Enhatls78067	enhancer	E4342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1846	0.84158		TOB1	chr17	50862222	50867978	36546	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5986
enhrx-50689	chr14	67959498	67959499	67492781	67492782	9767	hg38	N/A	enh15697	N/A	Enhatls54667	enhancer	E4343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055427	0.84173		TMEM229B	chr14	67470268	67533739	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2646
enhrx-100173	chr2	226244610	226244611	225379894	225379895	9768	hg38	N/A	enh97085	N/A	Enhatls107167	enhancer	E4344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1918	0.84173		NYAP2	chr2	225399709	225729887	17771	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12099
enhrx-967	chr1	8472762	8472763	8412702	8412703	9769	hg38	N/A	enh42	N/A	Enhatls1035	enhancer	E4345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081554	0.84174		RERE	chr1	8352396	8848921	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	966
enhrx-131176	chr5	32563863	32563864	32563757	32563758	9770	hg38	N/A	enh55192	N/A	Enhatls140212	enhancer	E4346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0078578	0.84221		SUB1	chr5	32531632	32604079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	967
enhrx-94039	chr2	111505350	111505351	110747773	110747774	9771	hg38	N/A	enh69821	N/A	Enhatls100712	enhancer	E4347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13562	0.84221		ACOXL	chr2	110732538	111118548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5965
enhrx-8698	chr1	109609084	109609085	109066462	109066463	9772	hg38	N/A	N/A	N/A	Enhatls9386	enhancer	E4348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15632	0.84238		TAF13	chr1	109062495	109076012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8697
enhrx-91360	chr2	64417094	64417095	64189960	64189961	9773	hg38	N/A	enh76261	N/A	Enhatls97885	enhancer	E4349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09149	0.84238		PELI1	chr2	64092651	64144420	44717	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3286
enhrx-151163	chr7	80411026	80411027	80781710	80781711	9774	hg38	N/A	enh40311	N/A	Enhatls161604	enhancer	E4350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018809	0.84268		SEMA3C	chr7	80742537	80922359	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3975
enhrx-126527	chr4	87891789	87891790	86970637	86970638	9775	hg38	N/A	enh8077	N/A	Enhatls135346	enhancer	E4351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098796	0.84302		AFF1	chr4	86935010	87141039	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4071
enhrx-33768	chr11	119027999	119028000	119157289	119157290	9776	hg38	N/A	N/A	N/A	Enhatls36634	enhancer	E4352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10599	0.84346		ABCG4	chr11	119149051	119162653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8437
enhrx-137593	chr5	171373571	171373572	171946567	171946568	9777	hg38	N/A	enh55590	N/A	Enhatls147045	enhancer	E4353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12344	0.84346		FBXW11	chr5	171861548	172006873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7384
enhrx-170613	chrX	4594192	4594193	4676151	4676152	9778	hg38	N/A	enh85539	N/A	Enhatls182570	enhancer	E4354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019358	0.84347		PRKX	chrX	3604339	3713649	953296	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	330
enhrx-161563	chr8	125683900	125683901	124671659	124671660	9779	hg38	N/A	enh25279	N/A	Enhatls172558	enhancer	E4355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10926	0.84347		MTSS1	chr8	124550783	124728473	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5354
enhrx-166932	chr9	109728968	109728969	106966687	106966688	9780	hg38	N/A	enh25842	N/A	Enhatls178669	enhancer	E4356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072073	0.84347		ZNF462	chr9	106863165	107013634	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4199
enhrx-3985	chr1	34872898	34872899	34407297	34407298	9781	hg38	N/A	enh95843	N/A	Enhatls4418	enhancer	E4357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13829	0.84359		C1orf94	chr1	34166882	34219131	185354	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3984
enhrx-18594	chr10	19790128	19790129	19501199	19501200	9782	hg38	N/A	enh96033	N/A	Enhatls20352	enhancer	E4358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030432	0.84359		MALRD1	chr10	19048800	19734478	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1029
enhrx-109777	chr22	31709516	31709517	31313530	31313531	9783	hg38	N/A	enh20137	N/A	Enhatls117456	enhancer	E4359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040291	0.84359		PATZ1	chr22	31325803	31346346	10050	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1608
enhrx-173701	chrX	70755211	70755212	71535361	71535362	9784	hg38	N/A	N/A	N/A	Enhatls185875	enhancer	E4360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011933	0.8439		OGT	chrX	71533100	71575892	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3418
enhrx-109168	chr22	25619582	25619583	25223615	25223616	9785	hg38	N/A	N/A	N/A	Enhatls116823	enhancer	E4361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088127	0.84391		CRYBB2	chr22	25212563	25231870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	999
enhrx-114764	chr3	48657710	48657711	48620277	48620278	9786	hg38	N/A	enh20580	N/A	Enhatls122802	enhancer	E4362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020354	0.84394		TMEM89	chr3	48620758	48621769	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2893
enhrx-27668	chr11	32183192	32183193	32161646	32161647	9787	hg38	N/A	enh103508	N/A	Enhatls30115	enhancer	E4363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14609	0.84394		RCN1	chr11	32091073	32105722	54678	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2337
enhrx-26787	chr11	14051714	14051715	14030167	14030168	9788	hg38	N/A	enh50718	N/A	Enhatls29208	enhancer	E4364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10385	0.84394		SPON1	chr11	13962722	14268133	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1456
enhrx-48779	chr14	25840452	25840453	25371246	25371247	9789	hg38	N/A	enh96473	N/A	Enhatls52660	enhancer	E4365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032462	0.84394		STXBP6	chr14	24809453	25050147	319033	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	736
enhrx-129981	chr4	185870318	185870319	184949164	184949165	9790	hg38	N/A	N/A	N/A	Enhatls138961	enhancer	E4366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.023618	0.84394		HELT	chr4	185018489	185020953	58779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7525
enhrx-141236	chr6	41861103	41861104	41893365	41893366	9791	hg38	N/A	N/A	N/A	Enhatls150995	enhancer	E4367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032569	0.84394		USP49	chr6	41789895	41895375	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2824
enhrx-36248	chr12	15427038	15427039	15274104	15274105	9792	hg38	N/A	enh58406	N/A	Enhatls39316	enhancer	E4368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097506	0.84396		RERG	chr12	15107782	15348598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1558
enhrx-102480	chr20	14189736	14189737	14209090	14209091	9793	hg38	N/A	N/A	N/A	Enhatls109577	enhancer	E4369	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1163	0.84396		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	908
enhrx-2136	chr1	19325893	19325894	18999399	18999400	9794	hg38	N/A	enh11568	N/A	Enhatls2387	enhancer	E4370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13899	0.84406		IFFO2	chr1	18904279	18956676	41921	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-165176	chr9	74832457	74832458	72217541	72217542	9795	hg38	N/A	N/A	N/A	Enhatls176769	enhancer	E4371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.041994	0.84406		GDA	chr9	72114594	72253560	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2443
enhrx-107522	chr21	43751243	43751244	42331133	42331134	9796	hg38	N/A	enh53881	N/A	Enhatls114968	enhancer	E4372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18459	0.84406		TFF2	chr21	42346356	42350994	8387	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1405
enhrx-97682	chr2	183819664	183819665	182954936	182954937	9797	hg38	N/A	N/A	N/A	Enhatls104533	enhancer	E4373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27541	0.84406		NCKAP1	chr2	182909114	183038858	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9608
enhrx-47614	chr13	110500350	110500351	109848003	109848004	9798	hg38	N/A	N/A	N/A	Enhatls51417	enhancer	E4374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13587	0.84406		IRS2	chr13	109752694	109786583	56455	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3236
enhrx-102912	chr20	23582295	23582296	23601658	23601659	9799	hg38	N/A	N/A	N/A	Enhatls110037	enhancer	E4375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10519	0.84406		CST9	chr20	23602409	23605917	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1340
enhrx-110439	chr22	38574245	38574246	38178238	38178239	9800	hg38	N/A	enh6854	N/A	Enhatls118186	enhancer	E4376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2165	0.84406		PLA2G6	chr22	38111494	38214778	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2270
enhrx-96219	chr2	161078295	161078296	160221784	160221785	9801	hg38	N/A	enh18946	fant9066	Enhatls103001	enhancer	E4377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082216	0.84451		ITGB6	chr2	160099666	160200313	21352	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-45302	chr13	34187521	34187522	33613384	33613385	9802	hg38	N/A	enh15223	N/A	Enhatls48899	enhancer	E4378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028472	0.8452		RFC3	chr13	33818068	33966558	201809	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	924
enhrx-117119	chr3	101881996	101881997	102163152	102163153	9803	hg38	N/A	enh20759	N/A	Enhatls125337	enhancer	E4379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068199	0.8452		ZPLD1	chr3	102099243	102479841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5248
enhrx-158469	chr8	41943393	41943394	42085875	42085876	9804	hg38	N/A	enh24964	N/A	Enhatls169301	enhancer	E4380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078305	0.84641		KAT6A	chr8	41929478	42051994	31034	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2260
enhrx-34339	chr11	125953134	125953135	126083239	126083240	9805	hg38	N/A	enh47535	N/A	Enhatls37246	enhancer	E4381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11935	0.84643		CDON	chr11	125955795	126063335	14036	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9008
enhrx-77691	chr18	39721596	39721597	42141632	42141633	9806	hg38	N/A	N/A	N/A	Enhatls83355	enhancer	E4382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044903	0.84643		PIK3C3	chr18	41955233	42087830	28835	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1709
enhrx-29308	chr11	61146318	61146319	61378846	61378847	9807	hg38	N/A	enh13954	fant38736	Enhatls31830	enhancer	E4383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18299	0.84663		TMEM138	chr11	61361963	61377890	887	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3977
enhrx-136206	chr5	143065093	143065094	143685528	143685529	9808	hg38	N/A	enh22675	N/A	Enhatls145521	enhancer	E4384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00071905	0.84689		HMHB1	chr5	143812160	143820716	124471	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5997
enhrx-151133	chr7	79768757	79768758	80139441	80139442	9809	hg38	N/A	enh24284	N/A	Enhatls161568	enhancer	E4385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051411	0.84697		GNAI1	chr7	79768049	80226181	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3945
enhrx-104418	chr20	42794771	42794772	44166131	44166132	9810	hg38	N/A	enh19648	N/A	Enhatls111668	enhancer	E4386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043121	0.84698		JPH2	chr20	44106589	44187188	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2846
enhrx-23656	chr10	108365781	108365782	106606023	106606024	9811	hg38	N/A	N/A	N/A	Enhatls25965	enhancer	E4387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30693	0.84698		SORCS1	chr10	106573662	107164706	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6091
enhrx-161913	chr8	134758954	134758955	133746711	133746712	9812	hg38	N/A	N/A	N/A	Enhatls172951	enhancer	E4388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31741	0.84828		ST3GAL1	chr8	133454847	133571925	170008	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5704
enhrx-133257	chr5	75932510	75932511	76636685	76636686	9813	hg38	N/A	N/A	N/A	Enhatls142377	enhancer	E4389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.032588	0.84828		IQGAP2	chr5	76403284	76708132	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3048
enhrx-150675	chr7	73890221	73890222	74475891	74475892	9814	hg38	N/A	enh24248	N/A	Enhatls161057	enhancer	E4390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053431	0.84838		GTF2IRD1	chr7	74453789	74602605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3487
enhrx-104828	chr20	45594450	45594451	46965811	46965812	9815	hg38	N/A	enh19668	N/A	Enhatls112086	enhancer	E4391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037659	0.84842		EYA2	chr20	46894623	47188844	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3256
enhrx-92386	chr2	85779327	85779328	85552204	85552205	9816	hg38	N/A	N/A	N/A	Enhatls98983	enhancer	E4392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082328	0.84869		GGCX	chr2	85544719	85561532	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4312
enhrx-109533	chr22	30206384	30206385	29810395	29810396	9817	hg38	N/A	N/A	N/A	Enhatls117210	enhancer	E4393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052673	0.84962		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1364
enhrx-49848	chr14	55140549	55140550	54673831	54673832	9818	hg38	N/A	enh3200	N/A	Enhatls53782	enhancer	E4394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020998	0.84962		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1805
enhrx-137677	chr5	173251403	173251404	173824400	173824401	9819	hg38	N/A	enh8886	fant20918	Enhatls147152	enhancer	E4395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012251	0.84962		CPEB4	chr5	173888348	173961980	63684	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7468
enhrx-113302	chr3	32497758	32497759	32456266	32456267	9820	hg38	N/A	enh7087	N/A	Enhatls121235	enhancer	E4396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1739	0.84962		CMTM7	chr3	32391697	32455528	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1431
enhrx-126913	chr4	99609826	99609827	98688675	98688676	9821	hg38	N/A	enh63337	N/A	Enhatls135750	enhancer	E4397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063993	0.84962		TSPAN5	chr4	98470366	98658611	26384	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4457
enhrx-28593	chr11	48108233	48108234	48086681	48086682	9822	hg38	N/A	enh1784	N/A	Enhatls31101	enhancer	E4398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28509	0.84962		PTPRJ	chr11	47980424	48170839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3262
enhrx-138688	chr6	7008882	7008883	7008649	7008650	9823	hg38	N/A	enh22972	N/A	Enhatls148271	enhancer	E4399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10903	0.84998		RREB1	chr6	7107596	7251980	96815	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	276
enhrx-83414	chr19	31645182	31645183	31154276	31154277	9824	hg38	N/A	enh32922	N/A	Enhatls89462	enhancer	E4400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042321	0.85006		TSHZ3	chr19	31274944	31349436	118461	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4384
enhrx-46684	chr13	76259676	76259677	75685540	75685541	9825	hg38	N/A	enh15393	N/A	Enhatls50405	enhancer	E4401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.020571	0.85006		LMO7	chr13	75620433	75859870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2306
enhrx-110602	chr22	39679183	39679184	39283178	39283179	9826	hg38	N/A	enh6860	N/A	Enhatls118367	enhancer	E4402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10806	0.85006		RPL3	chr22	39312881	39319623	29377	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2433
enhrx-27438	chr11	24479753	24479754	24458207	24458208	9827	hg38	N/A	N/A	N/A	Enhatls29887	enhancer	E4403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070883	0.85006		LUZP2	chr11	24497052	25082638	5103	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2107
enhrx-174041	chrX	77205623	77205624	77950126	77950127	9828	hg38	N/A	enh61710	N/A	Enhatls186210	enhancer	E4404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10322	0.85006		PGK1	chrX	77910738	78129295	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-174041	chrX	77205623	77205624	77950126	77950127	9829	hg38	N/A	enh61710	N/A	Enhatls186210	enhancer	E4404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10322	0.85006		ATP7A	chrX	77910689	78050395	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3758
enhrx-139164	chr6	18425647	18425648	18425416	18425417	9830	hg38	N/A	enh63518	N/A	Enhatls148775	enhancer	E4405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.058535	0.85013		RNF144B	chr6	18387349	18468870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	752
enhrx-120334	chr3	157344845	157344846	157627056	157627057	9831	hg38	N/A	N/A	N/A	Enhatls128756	enhancer	E4407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20926	0.85051		VEPH1	chr3	157259741	157533619	86783	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8463
enhrx-41902	chr12	107630670	107630671	107236892	107236893	9832	hg38	N/A	enh29966	N/A	Enhatls45274	enhancer	E4408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055347	0.85064		ABTB3	chr12	107318420	107659642	73944	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7212
enhrx-59281	chr15	91919774	91919775	91376544	91376545	9833	hg38	N/A	enh96627	N/A	Enhatls63831	enhancer	E4409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073426	0.85064		SV2B	chr15	91099949	91302565	71871	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5983
enhrx-159075	chr8	60250976	60250977	59338417	59338418	9834	hg38	N/A	enh73270	N/A	Enhatls169925	enhancer	E4410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12272	0.85114		TOX	chr8	58805411	59119147	218333	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2866
enhrx-159479	chr8	70073866	70073867	69161631	69161632	9835	hg38	N/A	enh98120	N/A	Enhatls170346	enhancer	E4411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11693	0.85114		SULF1	chr8	69466623	69660915	302664	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3270
enhrx-41833	chr12	106752200	106752201	106358422	106358423	9836	hg38	N/A	N/A	N/A	Enhatls45204	enhancer	E4412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21112	0.85114		POLR3B	chr12	106357747	106510198	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7143
enhrx-61270	chr16	14211111	14211112	14117254	14117255	9837	hg38	N/A	enh96661	N/A	Enhatls65860	enhancer	E4413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0065321	0.85114		MRTFB	chr16	14071318	14266773	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1565
enhrx-24666	chr10	124940361	124940362	123180845	123180846	9838	hg38	N/A	enh79760	N/A	Enhatls27036	enhancer	E4414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013631	0.85137		BUB3	chr10	123154401	123170467	8363	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7101
enhrx-117744	chr3	115848279	115848280	116129432	116129433	9839	hg38	N/A	N/A	N/A	Enhatls126016	enhancer	E4415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0032545	0.85187		LSAMP	chr3	115802373	117139389	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5873
enhrx-128783	chr4	149700648	149700649	148779496	148779497	9840	hg38	N/A	enh21869	N/A	Enhatls137692	enhancer	E4416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030851	0.85187		NR3C2	chr4	148078761	148444698	330416	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6327
enhrx-74231	chr17	70680223	70680224	72684084	72684085	9841	hg38	N/A	enh4584	fant53635	Enhatls79695	enhancer	E4417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053175	0.85213		SLC39A11	chr17	72645948	73092712	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7500
enhrx-161644	chr8	128764188	128764189	127751942	127751943	9842	hg38	N/A	N/A	N/A	Enhatls172651	enhancer	E4418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022675	0.85223		MYC	chr8	127735433	127742951	8419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5435
enhrx-108360	chr22	18414236	18414237	17931470	17931471	9843	hg38	N/A	enh6709	N/A	Enhatls115887	enhancer	E4419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052304	0.85223		MICAL3	chr22	17787648	18024561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	191
enhrx-80672	chr19	7683480	7683481	7618594	7618595	9844	hg38	N/A	N/A	N/A	Enhatls86537	enhancer	E4420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098625	0.85223		XAB2	chr19	7619524	7629545	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1642
enhrx-139050	chr6	16986387	16986388	16986156	16986157	9845	hg38	N/A	enh38841	N/A	Enhatls148662	enhancer	E4421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0029812	0.85245		STMND1	chr6	17102049	17131378	113426	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	638
enhrx-102962	chr20	24998176	24998177	25017540	25017541	9846	hg38	N/A	enh19562	N/A	Enhatls110087	enhancer	E4422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0025372	0.85245		ACSS1	chr20	25006229	25058980	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1390
enhrx-29332	chr11	61256649	61256650	61489177	61489178	9847	hg38	N/A	N/A	N/A	Enhatls31854	enhancer	E4423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075	0.85245		SAXO4	chr11	61481119	61490931	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4001
enhrx-156054	chr7	156945235	156945236	157152541	157152542	9848	hg38	N/A	enh10110	N/A	Enhatls166719	enhancer	E4424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11976	0.85245		UBE3C	chr7	157138925	157269370	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8866
enhrx-77197	chr18	24125405	24125406	26545441	26545442	9849	hg38	N/A	enh62673	N/A	Enhatls82850	enhancer	E4425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11887	0.85245		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1215
enhrx-17893	chr10	6340126	6340127	6298163	6298164	9850	hg38	N/A	enh1070	fant34606	Enhatls19554	enhancer	E4426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05259	0.85245		PFKFB3	chr10	6144933	6254644	43477	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	328
enhrx-83366	chr19	29880753	29880754	29389846	29389847	9851	hg38	N/A	enh96834	N/A	Enhatls89412	enhancer	E4427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10055	0.85245		VSTM2B	chr19	29525993	29564551	134581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4336
enhrx-119483	chr3	138758474	138758475	139039632	139039633	9852	hg38	N/A	N/A	N/A	Enhatls127853	enhancer	E4428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11265	0.85245		MRPS22	chr3	139005805	139360497	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7612
enhrx-176993	chrX	149209637	149209638	150041406	150041407	9853	hg38	N/A	enh26463	N/A	Enhatls189243	enhancer	E4429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.041213	0.85245		EOLA2	chrX	149929526	149938491	94554	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6710
enhrx-173208	chrX	56969896	56969897	56943463	56943464	9854	hg38	N/A	N/A	N/A	Enhatls185403	enhancer	E4430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029914	0.85245		NBDY	chrX	56729240	56819179	7084	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2925
enhrx-119395	chr3	138001075	138001076	138282233	138282234	9855	hg38	N/A	enh20973	N/A	Enhatls127762	enhancer	E4431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20199	0.85245		ARMC8	chr3	138187247	138298384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7524
enhrx-119395	chr3	138001075	138001076	138282233	138282234	9856	hg38	N/A	enh20973	N/A	Enhatls127762	enhancer	E4431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20199	0.85245		NME9	chr3	138261436	138329886	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7524
enhrx-75970	chr17	81137585	81137586	83189816	83189817	9857	hg38	N/A	enh17465	N/A	Enhatls81526	enhancer	E4432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0019311	0.85288		METRNL	chr17	83079608	83095122	88038	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9239
enhrx-44687	chr13	24787022	24787023	24212884	24212885	9858	hg38	N/A	enh2724	N/A	Enhatls48219	enhancer	E4433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15246	0.85288		SPATA13	chr13	23979804	24307074	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	309
enhrx-47339	chr13	100517858	100517859	99865604	99865605	9859	hg38	N/A	N/A	N/A	Enhatls51128	enhancer	E4434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28701	0.85288		CLYBL	chr13	99606668	99897134	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2961
enhrx-52540	chr14	98715975	98715976	98249638	98249639	9860	hg38	N/A	enh96554	N/A	Enhatls56668	enhancer	E4435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091948	0.85295		BCL11B	chr14	99169286	99272197	917569	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4497
enhrx-98915	chr2	205211385	205211386	204346662	204346663	9861	hg38	N/A	N/A	N/A	Enhatls105834	enhancer	E4436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076754	0.85302		PARD3B	chr2	204545474	205620162	194153	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10841
enhrx-169150	chr9	134888316	134888317	132012929	132012930	9862	hg38	N/A	enh42323	N/A	Enhatls181067	enhancer	E4437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031324	0.85302		MED27	chr9	131852927	132079867	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6417
enhrx-43822	chr12	124716730	124716731	124232184	124232185	9863	hg38	N/A	enh43847	N/A	Enhatls47303	enhancer	E4439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27128	0.85312		RFLNA	chr12	123973240	124316024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9132
enhrx-20887	chr10	72013628	72013629	70253872	70253873	9864	hg38	N/A	N/A	N/A	Enhatls22997	enhancer	E4440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.053393	0.85312		NPFFR1	chr10	70247328	70284004	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3322
enhrx-112010	chr3	4566303	4566304	4524619	4524620	9865	hg38	N/A	enh63091	N/A	Enhatls119853	enhancer	E4441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061371	0.85312		ITPR1	chr3	4493344	4847506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	139
enhrx-49849	chr14	55176794	55176795	54710076	54710077	9866	hg38	N/A	enh3201	N/A	Enhatls53783	enhancer	E4442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015201	0.85312		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1806
enhrx-104566	chr20	43958367	43958368	45329727	45329728	9867	hg38	N/A	N/A	N/A	Enhatls111820	enhancer	E4443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.018276	0.85349		SDC4	chr20	45325287	45348424	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2994
enhrx-8078	chr1	95028640	95028641	94563084	94563085	9868	hg38	N/A	enh61876	N/A	Enhatls8748	enhancer	E4444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12083	0.85363		F3	chr1	94529172	94541759	16251	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8077
enhrx-159013	chr8	58499944	58499945	57587385	57587386	9869	hg38	N/A	enh25011	N/A	Enhatls169858	enhancer	E4445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0037045	0.85419		FAM110B	chr8	57994522	58148788	400811	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2804
enhrx-95533	chr2	144375552	144375553	143617983	143617984	9870	hg38	N/A	N/A	N/A	Enhatls102272	enhancer	E4446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099319	0.85454		ARHGAP15	chr2	143091361	143768352	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7459
enhrx-77199	chr18	24165223	24165224	26585259	26585260	9871	hg38	N/A	N/A	N/A	Enhatls82851	enhancer	E4447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02772	0.85474		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-145628	chr6	140784065	140784066	140462928	140462929	9872	hg38	N/A	enh23706	N/A	Enhatls155669	enhancer	E4448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033297	0.85474		CITED2	chr6	139371806	139374648	1085581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7216
enhrx-90919	chr2	55383305	55383306	55156169	55156170	9873	hg38	N/A	enh5542	N/A	Enhatls97424	enhancer	E4449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0017278	0.85474		CLHC1	chr2	55172546	55232563	10813	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-40828	chr12	88960426	88960427	88566649	88566650	9874	hg38	N/A	enh57617	N/A	Enhatls44121	enhancer	E4450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21274	0.85506		KITLG	chr12	88492792	88580851	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6138
enhrx-128596	chr4	145204918	145204919	144283765	144283766	9875	hg38	N/A	N/A	N/A	Enhatls137501	enhancer	E4451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10672	0.85506		GYPA	chr4	144109302	144140751	70300	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6140
enhrx-146535	chr6	159331617	159331618	158910585	158910586	9876	hg38	N/A	enh9511	N/A	Enhatls156642	enhancer	E4452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19918	0.85506		RSPH3	chr6	158972870	159000202	61998	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8123
enhrx-113885	chr3	40438141	40438142	40396650	40396651	9877	hg38	N/A	enh54084	N/A	Enhatls121873	enhancer	E4453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081538	0.85506		ENTPD3	chr3	40387183	40428744	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2014
enhrx-89483	chr2	27819698	27819699	27596831	27596832	9878	hg38	N/A	N/A	N/A	Enhatls95836	enhancer	E4454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.095986	0.85506		ZNF512	chr2	27582968	27623217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1409
enhrx-4727	chr1	41915447	41915448	41449776	41449777	9879	hg38	N/A	enh26653	fant1360	Enhatls5187	enhancer	E4455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0063	0.85506		EDN2	chr1	41478774	41484683	28808	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4726
enhrx-66549	chr16	89477327	89477328	89410919	89410920	9880	hg38	N/A	enh32029	N/A	Enhatls71455	enhancer	E4456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03485	0.85506		ANKRD11	chr16	89267629	89490561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6844
enhrx-15843	chr1	223928801	223928802	223741099	223741100	9881	hg38	N/A	enh12712	N/A	Enhatls17392	enhancer	E4457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022265	0.85509		CAPN2	chr1	223701592	223776018	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15842
enhrx-47066	chr13	95740205	95740206	95087951	95087952	9882	hg38	N/A	enh80677	N/A	Enhatls50823	enhancer	E4458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13804	0.85509		ABCC4	chr13	95019834	95301451	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2688
enhrx-65472	chr16	71868358	71868359	71834455	71834456	9883	hg38	N/A	N/A	N/A	Enhatls70257	enhancer	E4459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0070717	0.85539		ATXN1L	chr16	71808438	71857328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5767
enhrx-60966	chr16	5788864	5788865	5738863	5738864	9884	hg38	N/A	N/A	N/A	Enhatls65542	enhancer	E4460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0023042	0.85616		RBFOX1	chr16	5239801	7713340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1261
enhrx-97172	chr2	175450081	175450082	174585353	174585354	9885	hg38	N/A	N/A	N/A	Enhatls104005	enhancer	E4461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037467	0.85627		WIPF1	chr2	174559571	174682899	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9098
enhrx-145554	chr6	138790333	138790334	138469196	138469197	9886	hg38	N/A	enh39559	N/A	Enhatls155582	enhancer	E4462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.074421	0.85646		NHSL1	chr6	138422042	138692571	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7142
enhrx-36690	chr12	24907822	24907823	24754888	24754889	9887	hg38	N/A	enh29449	N/A	Enhatls39774	enhancer	E4463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036705	0.85647		BCAT1	chr12	24810023	24949101	46663	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2000
enhrx-14710	chr1	205343475	205343476	205374347	205374348	9888	hg38	N/A	enh27435	N/A	Enhatls16197	enhancer	E4464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20145	0.85647		LEMD1	chr1	205381377	205455954	2371	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14709
enhrx-143987	chr6	107039522	107039523	106591647	106591648	9889	hg38	N/A	N/A	N/A	Enhatls153867	enhancer	E4465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064125	0.85647		RTN4IP1	chr6	106570770	106629498	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5575
enhrx-61737	chr16	19151676	19151677	19140354	19140355	9890	hg38	N/A	enh16588	N/A	Enhatls66348	enhancer	E4466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11997	0.85647		ITPRIPL2	chr16	19113963	19121629	5295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-138926	chr6	12344284	12344285	12344052	12344053	9891	hg38	N/A	enh38802	N/A	Enhatls148525	enhancer	E4467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14974	0.85647		EDN1	chr6	12290360	12297194	46328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	514
enhrx-158840	chr8	53167634	53167635	52255074	52255075	9892	hg38	hs698	N/A	N/A	Enhatls169684	enhancer	E4468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065565	0.85647		ST18	chr8	52110837	52409805	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2631
enhrx-119327	chr3	136351860	136351861	136633018	136633019	9893	hg38	N/A	enh77075	N/A	Enhatls127688	enhancer	E4469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031246	0.85647		STAG1	chr3	136336235	136752403	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7456
enhrx-84212	chr19	38570857	38570858	38080217	38080218	9894	hg38	N/A	N/A	N/A	Enhatls90272	enhancer	E4470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046915	0.85761		SIPA1L3	chr19	37907207	38208369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5182
enhrx-77200	chr18	24198501	24198502	26618537	26618538	9895	hg38	N/A	enh17618	N/A	Enhatls82852	enhancer	E4471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20031	0.85761		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1218
enhrx-115747	chr3	54356664	54356665	54322637	54322638	9896	hg38	N/A	N/A	N/A	Enhatls123835	enhancer	E4472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0036338	0.85761		CACNA2D3	chr3	54122551	55074557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3876
enhrx-94456	chr2	118870731	118870732	118113155	118113156	9897	hg38	N/A	enh18830	N/A	Enhatls101145	enhancer	E4473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054316	0.85761		INSIG2	chr2	118088470	118110997	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6382
enhrx-119575	chr3	141085243	141085244	141366401	141366402	9898	hg38	N/A	enh100104	N/A	Enhatls127946	enhancer	E4474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21058	0.85828		ZBTB38	chr3	141324212	141449792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7704
enhrx-78712	chr18	67672906	67672907	70005670	70005671	9899	hg38	N/A	N/A	N/A	Enhatls84446	enhancer	E4475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12353	0.85828		RTTN	chr18	70003030	70205687	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2730
enhrx-132066	chr5	53553699	53553700	54257869	54257870	9900	hg38	N/A	N/A	N/A	Enhatls141148	enhancer	E4476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21597	0.85828		ARL15	chr5	53883941	54310582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1857
enhrx-33307	chr11	115595574	115595575	115724856	115724857	9901	hg38	N/A	enh96252	N/A	Enhatls36142	enhancer	E4477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21248	0.85828		CADM1	chr11	115169235	115504957	217851	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7976
enhrx-1511	chr1	12545808	12545809	12485753	12485754	9902	hg38	N/A	enh11513	N/A	Enhatls1632	enhancer	E4478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23427	0.85828		VPS13D	chr1	12230029	12512047	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1510
enhrx-70179	chr17	33415189	33415190	35088170	35088171	9903	hg38	N/A	N/A	N/A	Enhatls75312	enhancer	E4479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022367	0.85828		RFFL	chr17	35005989	35089319	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3448
enhrx-65568	chr16	72961741	72961742	72927842	72927843	9904	hg38	N/A	enh16767	N/A	Enhatls70359	enhancer	E4480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12005	0.85828		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5863
enhrx-57384	chr15	69775289	69775290	69482950	69482951	9905	hg38	N/A	enh44142	N/A	Enhatls61742	enhancer	E4481	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00080221	0.85828		RPLP1	chr15	69452813	69456205	23544	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4086
enhrx-161139	chr8	116479983	116479984	115467756	115467757	9906	hg38	N/A	enh73474	N/A	Enhatls172096	enhancer	E4482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19093	0.85842		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4930
enhrx-50257	chr14	61113906	61113907	60647188	60647189	9907	hg38	N/A	N/A	fant46207	Enhatls54215	enhancer	E4483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10215	0.85954		SIX1	chr14	60643420	60658259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2214
enhrx-81008	chr19	9142926	9142927	9032250	9032251	9908	hg38	N/A	enh81485	N/A	Enhatls86881	enhancer	E4484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049411	0.85954		MUC16	chr19	8848843	9010390	19720	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1978
enhrx-26574	chr11	10136373	10136374	10114826	10114827	9909	hg38	N/A	enh28581	N/A	Enhatls28971	enhancer	E4485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.018297	0.85954		SBF2	chr11	9776775	10294227	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1243
enhrx-47614	chr13	110456393	110456394	109804046	109804047	9910	hg38	N/A	enh80719	N/A	Enhatls51417	enhancer	E4486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019566	0.85954		IRS2	chr13	109752694	109786583	14436	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3236
enhrx-40830	chr12	89151913	89151914	88758136	88758137	9911	hg38	N/A	N/A	N/A	Enhatls44123	enhancer	E4487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01201	0.85954		KITLG	chr12	88492792	88580851	174488	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6140
enhrx-116462	chr3	71503154	71503155	71454003	71454004	9912	hg38	N/A	enh7318	N/A	Enhatls124633	enhancer	E4488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015795	0.85967		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4591
enhrx-20194	chr10	52795288	52795289	51035528	51035529	9913	hg38	N/A	enh67489	N/A	Enhatls22251	enhancer	E4489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16622	0.85967		PRKG1	chr10	50990887	52298423	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2629
enhrx-135485	chr5	133582613	133582614	134246922	134246923	9914	hg38	N/A	enh22585	N/A	Enhatls144738	enhancer	E4490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10141	0.85967		PPP2CA	chr5	134194034	134226073	12469	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5276
enhrx-141822	chr6	47102634	47102635	47134898	47134899	9915	hg38	N/A	enh23288	fant22849	Enhatls151626	enhancer	E4492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16532	0.85967		ADGRF1	chr6	46997707	47042332	92436	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3410
enhrx-157900	chr8	30580616	30580617	30723099	30723100	9916	hg38	N/A	enh10228	fant29201	Enhatls168701	enhancer	E4493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034844	0.85978		GSR	chr8	30678065	30727846	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1691
enhrx-163575	chr9	20319459	20319460	20319461	20319462	9917	hg38	N/A	enh41786	N/A	Enhatls174661	enhancer	E4494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12178	0.85978		MLLT3	chr9	20341668	20622499	19810	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	842
enhrx-133476	chr5	79250712	79250713	79954889	79954890	9918	hg38	N/A	enh63430	N/A	Enhatls142598	enhancer	E4495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062484	0.85978		MTX3	chr5	79976715	79991262	18120	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3267
enhrx-154546	chr7	135205579	135205580	135520831	135520832	9919	hg38	N/A	enh63720	N/A	Enhatls165162	enhancer	E4496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024824	0.85978		CNOT4	chr7	135361794	135510145	6697	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7358
enhrx-127888	chr4	120501648	120501649	119580493	119580494	9920	hg38	N/A	enh88863	N/A	Enhatls136762	enhancer	E4497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024452	0.85978		PDE5A	chr4	119494396	119628804	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5432
enhrx-40123	chr12	70346837	70346838	69953057	69953058	9921	hg38	N/A	N/A	N/A	Enhatls43381	enhancer	E4498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036266	0.85979		MYRFL	chr12	69825226	69959097	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5433
enhrx-127314	chr4	106879037	106879038	105957880	105957881	9922	hg38	N/A	N/A	N/A	Enhatls136165	enhancer	E4499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18456	0.85979		NPNT	chr4	105894774	106004027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4858
enhrx-46960	chr13	89714154	89714155	89061900	89061901	9923	hg38	N/A	N/A	N/A	Enhatls50707	enhancer	E4500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16967	0.86016		SLITRK5	chr13	87671370	87696272	1291545	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2582
enhrx-124615	chr4	48129405	48129406	48127388	48127389	9924	hg38	N/A	enh21498	N/A	Enhatls133345	enhancer	E4501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11447	0.86134		TXK	chr4	48066392	48134250	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2159
enhrx-117245	chr3	108124809	108124810	108405962	108405963	9925	hg38	N/A	N/A	N/A	Enhatls125480	enhancer	E4502	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13873	0.86171		MYH15	chr3	108380367	108529322	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5374
enhrx-161447	chr8	124576414	124576415	123564174	123564175	9926	hg38	N/A	enh25263	N/A	Enhatls172436	enhancer	E4503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10128	0.86171		FBXO32	chr8	123497888	123541206	11360	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5238
enhrx-128704	chr4	147500079	147500080	146578927	146578928	9927	hg38	N/A	enh77450	N/A	Enhatls137612	enhancer	E4504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20583	0.86171		SLC10A7	chr4	146253974	146521964	52610	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6248
enhrx-12039	chr1	164689135	164689136	164719898	164719899	9928	hg38	N/A	enh12338	N/A	Enhatls13336	enhancer	E4505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055317	0.86178		PBX1	chr1	164559183	164886007	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12038
enhrx-20277	chr10	59828819	59828820	58069059	58069060	9929	hg38	N/A	N/A	N/A	Enhatls22339	enhancer	E4506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1177	0.86178		IPMK	chr10	58191516	58267894	107707	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2712
enhrx-55600	chr15	46702132	46702133	46409934	46409935	9930	hg38	N/A	N/A	N/A	Enhatls59819	enhancer	E4507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035141	0.86178		SQOR	chr15	45631147	45691281	655897	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2302
enhrx-78393	chr18	56722330	56722331	59055098	59055099	9931	hg38	N/A	enh52777	N/A	Enhatls84107	enhancer	E4508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049248	0.86185		ZNF532	chr18	58862599	58986480	66729	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2411
enhrx-147561	chr7	4784597	4784598	4744966	4744967	9932	hg38	N/A	enh9573	N/A	Enhatls157696	enhancer	E4509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11686	0.86185		FOXK1	chr7	4682294	4771442	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	373
enhrx-144915	chr6	127468239	127468240	127147094	127147095	9933	hg38	N/A	enh100562	N/A	Enhatls154862	enhancer	E4510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17805	0.86185		RSPO3	chr6	127118670	127199481	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6503
enhrx-63177	chr16	31140079	31140080	31128758	31128759	9934	hg38	N/A	N/A	fant50422	Enhatls67857	enhancer	E4511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.093268	0.86271		KAT8	chr16	31114488	31131393	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3472
enhrx-113959	chr3	42122195	42122196	42080703	42080704	9935	hg38	N/A	enh7147	fant11785	Enhatls121948	enhancer	E4512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.007846	0.86271		TRAK1	chr3	42013801	42225890	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2088
enhrx-31725	chr11	78618787	78618788	78907742	78907743	9936	hg38	N/A	enh14146	N/A	Enhatls34474	enhancer	E4513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030705	0.86271		TENM4	chr11	78652828	79441030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6394
enhrx-28896	chr11	57532763	57532764	57765291	57765292	9937	hg38	N/A	N/A	N/A	Enhatls31418	enhancer	E4514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.1057	0.86271		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-171489	chrX	23890231	23890232	23872114	23872115	9938	hg38	N/A	enh93867	N/A	Enhatls183519	enhancer	E4515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087898	0.8632		APOO	chrX	23833352	23907938	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1206
enhrx-8874	chr1	110532252	110532253	109989630	109989631	9939	hg38	N/A	enh552	N/A	Enhatls9574	enhancer	E4516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12408	0.8632		AHCYL1	chr1	109984764	110023742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8873
enhrx-105154	chr20	50118764	50118765	51502225	51502226	9940	hg38	N/A	enh6540	N/A	Enhatls112459	enhancer	E4517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074284	0.86333		NFATC2	chr20	51386956	51562831	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3582
enhrx-10114	chr1	150341574	150341575	150369098	150369099	9941	hg38	N/A	N/A	N/A	Enhatls11314	enhancer	E4518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.032934	0.86388		RPRD2	chr1	150364146	150476566	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10113
enhrx-133924	chr5	91903729	91903730	92568022	92568023	9942	hg38	N/A	enh97699	N/A	Enhatls143074	enhancer	E4519	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19415	0.86388		NR2F1	chr5	93583221	93594611	1013114	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3715
enhrx-98097	chr2	192168599	192168600	191303873	191303874	9943	hg38	N/A	enh19101	N/A	Enhatls104952	enhancer	E4520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080942	0.86389		MYO1B	chr2	191245184	191425389	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10023
enhrx-111371	chr22	45865976	45865977	45470095	45470096	9944	hg38	N/A	enh20258	N/A	Enhatls119173	enhancer	E4521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25982	0.86389		FBLN1	chr22	45502237	45601135	6063	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3202
enhrx-90785	chr2	53725587	53725588	53498449	53498450	9945	hg38	N/A	enh88449	N/A	Enhatls97272	enhancer	E4522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23019	0.86406		ASB3	chr2	53532671	53860160	30215	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2711
enhrx-166917	chr9	108675271	108675272	105912990	105912991	9946	hg38	N/A	enh73768	fant33115	Enhatls178652	enhancer	E4523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0698	0.86415		TMEM38B	chr9	105694540	105776629	136247	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4184
enhrx-164547	chr9	38165041	38165042	38165044	38165045	9947	hg38	N/A	N/A	N/A	Enhatls175686	enhancer	E4524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058602	0.86415		SHB	chr9	37915897	38069227	93612	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1814
enhrx-70790	chr17	37661949	37661950	39505696	39505697	9948	hg38	N/A	N/A	fant52547	Enhatls75956	enhancer	E4525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12811	0.86415		CDK12	chr17	39461485	39534544	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4059
enhrx-71481	chr17	40892965	40892966	42740947	42740948	9949	hg38	N/A	N/A	N/A	Enhatls76705	enhancer	E4526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10673	0.86415		EZH1	chr17	42700274	42745049	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4750
enhrx-97926	chr2	190350117	190350118	189485391	189485392	9950	hg38	N/A	enh19083	N/A	Enhatls104780	enhancer	E4527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072212	0.86415		WDR75	chr2	189441473	189475552	3148	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-149379	chr7	42534134	42534135	42494535	42494536	9951	hg38	hs2079	enh46359	N/A	Enhatls159665	enhancer	E4528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01257	0.86415		GLI3	chr7	41960948	42264100	229717	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2191
enhrx-102493	chr20	14973862	14973863	14993216	14993217	9952	hg38	N/A	enh34560	N/A	Enhatls109591	enhancer	E4529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23974	0.86415		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	921
enhrx-77524	chr18	33038606	33038607	35458642	35458643	9953	hg38	N/A	enh4779	N/A	Enhatls83180	enhancer	E4530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05694	0.86501		INO80C	chr18	35452229	35497960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1542
enhrx-37183	chr12	32889583	32889584	32736649	32736650	9954	hg38	N/A	N/A	N/A	Enhatls40293	enhancer	E4531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10891	0.86501		DNM1L	chr12	32679199	32745650	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2493
enhrx-5483	chr1	47856656	47856657	47390984	47390985	9955	hg38	N/A	enh49734	N/A	Enhatls6000	enhancer	E4532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14646	0.86501		CMPK1	chr1	47333789	47394866	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5482
enhrx-57947	chr15	75930860	75930861	75638519	75638520	9956	hg38	N/A	N/A	N/A	Enhatls62341	enhancer	E4533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045731	0.86513		IMP3	chr15	75639084	75648706	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4649
enhrx-115355	chr3	52253504	52253505	52219488	52219489	9957	hg38	N/A	enh7218	N/A	Enhatls123413	enhancer	E4534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23296	0.86513		ALAS1	chr3	52198085	52214327	223	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3484
enhrx-138729	chr6	7418662	7418663	7418429	7418430	9958	hg38	N/A	N/A	N/A	Enhatls148312	enhancer	E4535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0081499	0.86513		RIOK1	chr6	7389807	7418037	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	317
enhrx-33265	chr11	114196345	114196346	114325623	114325624	9959	hg38	N/A	enh67942	N/A	Enhatls36098	enhancer	E4536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027986	0.86513		NNMT	chr11	114257830	114313536	8814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7934
enhrx-44101	chr12	132221931	132221932	131737386	131737387	9960	hg38	N/A	enh15109	N/A	Enhatls47617	enhancer	E4537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083511	0.86513		SFSWAP	chr12	131711089	131799738	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9411
enhrx-81008	chr19	9165636	9165637	9054960	9054961	9961	hg38	N/A	enh17908	N/A	Enhatls86881	enhancer	E4538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061828	0.86513		OR1M1	chr19	9087060	9095669	22852	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1978
enhrx-114549	chr3	47516862	47516863	47475372	47475373	9962	hg38	N/A	N/A	N/A	Enhatls122583	enhancer	E4539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.055519	0.86513		SCAP	chr3	47413680	47477126	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2678
enhrx-80365	chr19	6273981	6273982	6273970	6273971	9963	hg38	N/A	enh17889	fant56081	Enhatls86222	enhancer	E4540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023459	0.86513		MLLT1	chr19	6210380	6279975	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1335
enhrx-75471	chr17	78631965	78631966	80658165	80658166	9964	hg38	N/A	enh4633	N/A	Enhatls80992	enhancer	E4541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.090608	0.86513		RPTOR	chr17	80544837	80966368	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8740
enhrx-119209	chr3	134045971	134045972	134327129	134327130	9965	hg38	N/A	enh20955	fant13558	Enhatls127566	enhancer	E4542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019081	0.86513		AMOTL2	chr3	134355346	134375479	28139	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7338
enhrx-100000	chr2	220968502	220968503	220103781	220103782	9966	hg38	N/A	enh53577	N/A	Enhatls106992	enhancer	E4543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066413	0.86513		SLC4A3	chr2	219627393	219641980	458225	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11926
enhrx-31951	chr11	87067754	87067755	87356712	87356713	9967	hg38	N/A	enh1943	N/A	Enhatls34715	enhancer	E4544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0091106	0.86513		TMEM135	chr11	87037843	87328824	19275	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6620
enhrx-118970	chr3	131163205	131163206	131444361	131444362	9968	hg38	N/A	enh97349	N/A	Enhatls127317	enhancer	E4545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.04916	0.86513		MRPL3	chr3	131462211	131502983	15741	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7099
enhrx-82424	chr19	16844974	16844975	16734163	16734164	9969	hg38	N/A	enh17959	N/A	Enhatls88386	enhancer	E4546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13455	0.86513		NWD1	chr19	16719846	16817953	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3394
enhrx-56938	chr15	65277933	65277934	64985595	64985596	9970	hg38	N/A	N/A	fant48533	Enhatls61265	enhancer	E4547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023073	0.86513		SPG21	chr15	64963021	64990310	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3640
enhrx-56568	chr15	62042877	62042878	61750678	61750679	9971	hg38	N/A	enh58655	fant48422	Enhatls60863	enhancer	E4548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066788	0.86513		VPS13C	chr15	61852388	62060473	101493	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3270
enhrx-118291	chr3	124018030	124018031	124299183	124299184	9972	hg38	N/A	N/A	N/A	Enhatls126570	enhancer	E4549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0049334	0.86513		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6420
enhrx-86031	chr19	48151676	48151677	47648419	47648420	9973	hg38	N/A	enh18126	N/A	Enhatls92205	enhancer	E4550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10531	0.86513		BICRA	chr19	47608195	47703277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7001
enhrx-167916	chr9	125011138	125011139	122248859	122248860	9974	hg38	N/A	N/A	N/A	Enhatls179730	enhancer	E4551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076738	0.86513		RBM18	chr9	122237621	122264840	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5183
enhrx-165896	chr9	92284429	92284430	89669514	89669515	9975	hg38	N/A	enh25718	N/A	Enhatls177536	enhancer	E4552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050671	0.86513		GADD45G	chr9	89605011	89606555	58821	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3163
enhrx-77199	chr18	24147259	24147260	26567295	26567296	9976	hg38	N/A	enh108693	N/A	Enhatls82851	enhancer	E4553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0031674	0.86513		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-154133	chr7	128597882	128597883	128957828	128957829	9977	hg38	N/A	N/A	N/A	Enhatls164706	enhancer	E4554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083052	0.86513		TNPO3	chr7	128954179	129055173	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6945
enhrx-110602	chr22	39673502	39673503	39277497	39277498	9978	hg38	N/A	enh6860	N/A	Enhatls118367	enhancer	E4555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13603	0.86513		PDGFB	chr22	39223358	39244982	28659	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2433
enhrx-113033	chr3	21872297	21872298	21830805	21830806	9979	hg38	N/A	N/A	N/A	Enhatls120943	enhancer	E4556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.036588	0.86528		ZNF385D	chr3	21412217	22373193	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1162
enhrx-133352	chr5	76989885	76989886	77694060	77694061	9980	hg38	N/A	N/A	N/A	Enhatls142472	enhancer	E4557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033086	0.86592		TBCA	chr5	77691165	77868780	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3143
enhrx-32126	chr11	91971721	91971722	92238555	92238556	9981	hg38	N/A	enh67889	N/A	Enhatls34896	enhancer	E4558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052182	0.86592		FAT3	chr11	92224817	92896473	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6795
enhrx-46526	chr13	62615146	62615147	62041013	62041014	9982	hg38	N/A	N/A	N/A	Enhatls50233	enhancer	E4559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32216	0.86592		PCDH20	chr13	61409684	61415849	618999	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2148
enhrx-106490	chr21	27488867	27488868	26116550	26116551	9983	hg38	N/A	enh19857	fant59821	Enhatls113860	enhancer	E4560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25621	0.86592		APP	chr21	25880549	26171128	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	373
enhrx-98151	chr2	195191062	195191063	194326338	194326339	9984	hg38	N/A	N/A	N/A	Enhatls105008	enhancer	E4561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.03622	0.86612		SLC39A10	chr2	195575976	195737702	1236711	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10077
enhrx-155345	chr7	144474711	144474712	144777618	144777619	9985	hg38	N/A	enh24613	N/A	Enhatls165972	enhancer	E4562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20396	0.86612		TPK1	chr7	144451940	144836395	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8157
enhrx-81809	chr19	13019529	13019530	12908715	12908716	9986	hg38	N/A	enh104516	N/A	Enhatls87698	enhancer	E4563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16229	0.86612		GCDH	chr19	12891159	12914207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2779
enhrx-81809	chr19	13019529	13019530	12908715	12908716	9987	hg38	N/A	enh104516	N/A	Enhatls87698	enhancer	E4563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16229	0.86612		SYCE2	chr19	12898785	12919293	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2779
enhrx-157711	chr8	27730258	27730259	27872741	27872742	9988	hg38	N/A	enh110424	fant29094	Enhatls168475	enhancer	E4564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17625	0.86612		SCARA5	chr8	27869882	27992673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1502
enhrx-17719	chr10	3701190	3701191	3658998	3658999	9989	hg38	N/A	enh12915	N/A	Enhatls19357	enhancer	E4565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066875	0.86648		KLF6	chr10	3775995	3785281	112993	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	154
enhrx-112954	chr3	18799725	18799726	18758233	18758234	9990	hg38	N/A	enh48647	N/A	Enhatls120860	enhancer	E4566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0084887	0.86648		SATB1	chr3	18345376	18445621	312581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1083
enhrx-159560	chr8	71971488	71971489	71059253	71059254	9991	hg38	N/A	enh25070	N/A	Enhatls170438	enhancer	E4567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10256	0.86648		EYA1	chr8	71197432	71548136	137492	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3351
enhrx-88629	chr2	12248350	12248351	12108224	12108225	9992	hg38	N/A	enh5307	N/A	Enhatls94948	enhancer	E4568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07813	0.86721		LPIN1	chr2	11677594	11827409	279546	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	555
enhrx-124335	chr4	41052365	41052366	41050348	41050349	9993	hg38	N/A	enh21482	N/A	Enhatls133056	enhancer	E4569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11432	0.86756		APBB2	chr4	40810026	41214618	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1879
enhrx-116097	chr3	59436811	59436812	59451085	59451086	9994	hg38	N/A	enh48703	N/A	Enhatls124228	enhancer	E4570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11281	0.86756		FHIT	chr3	59747276	61251459	295721	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4226
enhrx-171419	chrX	21893323	21893324	21875205	21875206	9995	hg38	N/A	N/A	N/A	Enhatls183438	enhancer	E4571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086493	0.86796		MBTPS2	chrX	21839616	21885423	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1136
enhrx-5485	chr1	48150700	48150701	47685028	47685029	9996	hg38	N/A	enh115350	N/A	Enhatls6002	enhancer	E4572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07547	0.86801		TRABD2B	chr1	47760527	47997385	72773	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5484
enhrx-136192	chr5	142466938	142466939	143087373	143087374	9997	hg38	N/A	enh45981	N/A	Enhatls145504	enhancer	E4573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066851	0.86807		ARHGAP26	chr5	142770376	143229011	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5983
enhrx-116462	chr3	71439174	71439175	71390023	71390024	9998	hg38	N/A	enh7317	N/A	Enhatls124633	enhancer	E4574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18388	0.86826		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4591
enhrx-73089	chr17	56736644	56736645	58659283	58659284	9999	hg38	N/A	enh86261	N/A	Enhatls78463	enhancer	E4575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28621	0.86826		TEX14	chr17	58556677	58692055	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6358
enhrx-106770	chr21	33828147	33828148	32455839	32455840	10000	hg38	N/A	N/A	N/A	Enhatls114159	enhancer	E4576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16504	0.86826		EVA1C	chr21	32412684	32515397	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	653
enhrx-148450	chr7	22395817	22395818	22356198	22356199	10001	hg38	N/A	N/A	N/A	Enhatls158642	enhancer	E4577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.076326	0.86826		RAPGEF5	chr7	22118235	22357154	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1262
enhrx-24738	chr10	126416101	126416102	124727532	124727533	10002	hg38	N/A	enh1581	N/A	Enhatls27088	enhancer	E4578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0077969	0.86826		FAM53B	chr10	124619291	124744378	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7173
enhrx-131437	chr5	36652172	36652173	36652070	36652071	10003	hg38	N/A	enh22146	N/A	Enhatls140488	enhancer	E4579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14512	0.86826		SLC1A3	chr5	36596587	36688334	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1228
enhrx-66027	chr16	83860013	83860014	83826408	83826409	10004	hg38	N/A	enh52379	fant51176	Enhatls70876	enhancer	E4580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066565	0.86914		HSBP1	chr16	83807977	83819737	6412	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6322
enhrx-116510	chr3	73458335	73458336	73409184	73409185	10005	hg38	N/A	N/A	N/A	Enhatls124689	enhancer	E4581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.071948	0.86914		PDZRN3	chr3	73382430	73624941	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4639
enhrx-66210	chr16	85482610	85482611	85449004	85449005	10006	hg38	N/A	enh16870	N/A	Enhatls71076	enhancer	E4582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021888	0.86951		GSE1	chr16	85169524	85676204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6505
enhrx-26729	chr11	12745432	12745433	12723885	12723886	10007	hg38	N/A	enh13786	N/A	Enhatls29148	enhancer	E4583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054576	0.86951		TEAD1	chr11	12674420	12944737	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1398
enhrx-150274	chr7	65590562	65590563	66125575	66125576	10008	hg38	N/A	enh46391	N/A	Enhatls160630	enhancer	E4584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098133	0.86958		CRCP	chr7	66114825	66154568	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3086
enhrx-4426	chr1	39424810	39424811	38959138	38959139	10009	hg38	N/A	enh11754	N/A	Enhatls4871	enhancer	E4585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014246	0.86978		RHBDL2	chr1	38885806	38941830	6797	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4425
enhrx-38250	chr12	50903259	50903260	50509476	50509477	10010	hg38	N/A	enh14707	N/A	Enhatls41409	enhancer	E4586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079628	0.8712		DIP2B	chr12	50504984	50748657	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3560
enhrx-120342	chr3	158086297	158086298	158368508	158368509	10011	hg38	hs1413	enh7660	N/A	Enhatls128764	enhancer	E4587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10527	0.8712		RSRC1	chr3	158105854	158545730	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8471
enhrx-9248	chr1	114759373	114759374	114216751	114216752	10012	hg38	N/A	enh74369	N/A	Enhatls9986	enhancer	E4588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34227	0.87141		SYT6	chr1	114089291	114153880	59704	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9247
enhrx-168035	chr9	126361229	126361230	123598950	123598951	10013	hg38	N/A	N/A	N/A	Enhatls179849	enhancer	E4589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13978	0.87141		DENND1A	chr9	123379653	123930152	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5302
enhrx-123845	chr4	25206076	25206077	25204454	25204455	10014	hg38	N/A	N/A	N/A	Enhatls132534	enhancer	E4590	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20101	0.87141		PI4K2B	chr4	25160662	25279204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1389
enhrx-73567	chr17	61737411	61737412	63660051	63660052	10015	hg38	N/A	N/A	N/A	Enhatls78967	enhancer	E4591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031733	0.87145		MAP3K3	chr17	63622414	63696305	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6836
enhrx-148622	chr7	26137680	26137681	26098060	26098061	10016	hg38	N/A	enh24041	N/A	Enhatls158829	enhancer	E4592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061797	0.87145		NFE2L3	chr7	26152197	26187137	51718	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1434
enhrx-21369	chr10	76635854	76635855	74876096	74876097	10017	hg38	N/A	enh1346	N/A	Enhatls23502	enhancer	E4593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23067	0.87145		KAT6B	chr10	74824926	75032624	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3804
enhrx-105221	chr20	52740481	52740482	54123942	54123943	10018	hg38	N/A	enh19763	fant59253	Enhatls112538	enhancer	E4594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12029	0.87145		CYP24A1	chr20	54153445	54173986	29261	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3649
enhrx-52442	chr14	96207716	96207717	95741379	95741380	10019	hg38	N/A	enh15906	N/A	Enhatls56562	enhancer	E4595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0070287	0.87145		TCL1A	chr14	95709946	95714196	22113	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4399
enhrx-42835	chr12	116814357	116814358	116376552	116376553	10020	hg38	N/A	enh15026	N/A	Enhatls46255	enhancer	E4596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2953	0.87252		MED13L	chr12	115958575	116277693	82021	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8145
enhrx-139247	chr6	24341654	24341655	24341426	24341427	10021	hg38	N/A	enh84134	N/A	Enhatls148872	enhancer	E4597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11533	0.87299		DCDC2	chr6	24171754	24358059	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	835
enhrx-141997	chr6	51779836	51779837	51915038	51915039	10022	hg38	N/A	N/A	N/A	Enhatls151804	enhancer	E4598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097017	0.87299		PKHD1	chr6	51615298	52087613	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3585
enhrx-33018	chr11	111273977	111273978	111403252	111403253	10023	hg38	N/A	enh2001	N/A	Enhatls35827	enhancer	E4599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059367	0.87299		POU2AF1	chr11	111352254	111449981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7687
enhrx-154888	chr7	140010326	140010327	140310526	140310527	10024	hg38	N/A	enh98071	N/A	Enhatls165516	enhancer	E4600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022348	0.87316		SLC37A3	chr7	140333751	140404310	21166	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7700
enhrx-23880	chr10	115246657	115246658	113486898	113486899	10025	hg38	N/A	enh43414	N/A	Enhatls26215	enhancer	E4601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33167	0.87383		HABP2	chr10	113550836	113589602	53419	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6315
enhrx-176849	chrX	143927264	143927265	144845743	144845744	10026	hg38	N/A	N/A	N/A	Enhatls189089	enhancer	E4602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088923	0.87383		SPANXN1	chrX	145247502	145256208	400219	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6566
enhrx-68583	chr17	14696334	14696335	14793017	14793018	10027	hg38	N/A	enh60653	N/A	Enhatls73599	enhancer	E4603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1174	0.87383		PMP22	chr17	15229772	15272292	435502	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1852
enhrx-44516	chr13	21079920	21079921	20505781	20505782	10028	hg38	N/A	enh92437	N/A	Enhatls48030	enhancer	E4604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013604	0.87383		CRYL1	chr13	20403666	20525873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	138
enhrx-116624	chr3	78955572	78955573	78906422	78906423	10029	hg38	N/A	enh93180	N/A	Enhatls124807	enhancer	E4605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14523	0.87383		ROBO1	chr3	78597238	79767998	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4753
enhrx-137137	chr5	157495594	157495595	158068586	158068587	10030	hg38	N/A	N/A	N/A	Enhatls146546	enhancer	E4606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16843	0.87383		CLINT1	chr5	157785742	157859145	199543	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6928
enhrx-49789	chr14	53288603	53288604	52821885	52821886	10031	hg38	N/A	enh92533	N/A	Enhatls53722	enhancer	E4607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19786	0.87383		GNPNAT1	chr14	52775192	52791668	28160	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1746
enhrx-21652	chr10	84388296	84388297	82628540	82628541	10032	hg38	N/A	N/A	N/A	Enhatls23834	enhancer	E4608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27572	0.87383		NRG3	chr10	81875193	82987179	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4087
enhrx-19758	chr10	47627335	47627336	46256099	46256100	10033	hg38	N/A	enh64307	N/A	Enhatls21670	enhancer	E4609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2308	0.87383		ANTXRL	chr10	46286344	46330129	28026	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2193
enhrx-45217	chr13	32859616	32859617	32285479	32285480	10034	hg38	N/A	enh30192	N/A	Enhatls48796	enhancer	E4610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0048158	0.87383		FRY	chr13	31846712	32299125	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	839
enhrx-159867	chr8	83909029	83909030	82996794	82996795	10035	hg38	N/A	enh85073	N/A	Enhatls170770	enhancer	E4611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15673	0.87383		SNX16	chr8	81799580	81842866	1151105	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3658
enhrx-159738	chr8	77485769	77485770	76573534	76573535	10036	hg38	N/A	N/A	N/A	Enhatls170628	enhancer	E4612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023337	0.87383		ZFHX4	chr8	76681246	76867281	105117	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3529
enhrx-161599	chr8	126082084	126082085	125069842	125069843	10037	hg38	N/A	enh41536	N/A	Enhatls172594	enhancer	E4613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028091	0.87383		WASHC5	chr8	125024259	125091792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5390
enhrx-61737	chr16	19148752	19148753	19137430	19137431	10038	hg38	N/A	enh16588	N/A	Enhatls66348	enhancer	E4614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25454	0.87383		ITPRIPL2	chr16	19113963	19121629	5295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2032
enhrx-14752	chr1	205672376	205672377	205703248	205703249	10039	hg38	N/A	enh67253	N/A	Enhatls16243	enhancer	E4615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14775	0.87383		NUCKS1	chr1	205712821	205750182	5335	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14751
enhrx-121894	chr3	190309041	190309042	190591252	190591253	10040	hg38	N/A	enh21224	N/A	Enhatls130446	enhancer	E4616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0073828	0.87383		IL1RAP	chr3	190514050	190659750	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10023
enhrx-51886	chr14	89818112	89818113	89351768	89351769	10041	hg38	N/A	enh115570	N/A	Enhatls55948	enhancer	E4617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1402	0.87383		FOXN3	chr14	89124870	89619149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3843
enhrx-42919	chr12	117933030	117933031	117495225	117495226	10042	hg38	N/A	enh87999	N/A	Enhatls46349	enhancer	E4618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21429	0.87383		KSR2	chr12	117453011	117968990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8229
enhrx-128865	chr4	151956636	151956637	151035484	151035485	10043	hg38	N/A	enh21876	N/A	Enhatls137777	enhancer	E4619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0058103	0.87391		LRBA	chr4	150264434	151015727	14107	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6409
enhrx-78644	chr18	62740143	62740144	65072907	65072908	10044	hg38	N/A	N/A	N/A	Enhatls84371	enhancer	E4620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.08179	0.87391		CDH7	chr18	65750251	65890337	672700	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2662
enhrx-150361	chr7	70184250	70184251	70719264	70719265	10045	hg38	N/A	enh9858	N/A	Enhatls160737	enhancer	E4621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043619	0.87391		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3173
enhrx-2903	chr1	25032398	25032399	24705907	24705908	10046	hg38	N/A	enh139	N/A	Enhatls3232	enhancer	E4622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025948	0.87391		CLIC4	chr1	24745446	24844321	20859	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2902
enhrx-45088	chr13	30992678	30992679	30418541	30418542	10047	hg38	N/A	enh2751	N/A	Enhatls48648	enhancer	E4623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34983	0.87391		UBE2L5	chr13	30422487	30429758	3055	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	710
enhrx-6231	chr1	59680610	59680611	59214938	59214939	10048	hg38	N/A	enh87608	N/A	Enhatls6787	enhancer	E4624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15059	0.87399		FGGY	chr1	59296637	59762730	78555	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6230
enhrx-77288	chr18	28849697	28849698	31269734	31269735	10049	hg38	N/A	enh4745	N/A	Enhatls82939	enhancer	E4625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07091	0.874		DSG1	chr18	31318159	31359246	37248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1306
enhrx-112594	chr3	13508541	13508542	13467041	13467042	10050	hg38	N/A	N/A	N/A	Enhatls120485	enhancer	E4626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031809	0.874		HDAC11	chr3	13479723	13506424	10779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	723
enhrx-84534	chr19	39621139	39621140	39130499	39130500	10051	hg38	N/A	enh18060	N/A	Enhatls90616	enhancer	E4627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091286	0.87461		PAK4	chr19	39125769	39182816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5504
enhrx-55816	chr15	50296066	50296067	50003869	50003870	10052	hg38	N/A	N/A	N/A	Enhatls60058	enhancer	E4628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20115	0.87461		ATP8B4	chr15	49858237	50182817	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2518
enhrx-116714	chr3	87382702	87382703	87333552	87333553	10053	hg38	N/A	enh20730	fant12675	Enhatls124902	enhancer	E4629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071027	0.87461		POU1F1	chr3	87259403	87276584	56732	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4843
enhrx-19606	chr10	44740604	44740605	44245156	44245157	10054	hg38	N/A	enh13175	N/A	Enhatls21411	enhancer	E4630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04702	0.87462		CXCL12	chr10	44370164	44385097	122298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2041
enhrx-113866	chr3	40024596	40024597	39983105	39983106	10055	hg38	N/A	enh7137	N/A	Enhatls121852	enhancer	E4631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0072132	0.87462		MYRIP	chr3	39808913	40260321	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1995
enhrx-127087	chr4	102618566	102618567	101697409	101697410	10056	hg38	N/A	enh8119	N/A	Enhatls135927	enhancer	E4632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1687	0.87462		BANK1	chr4	101419960	102074812	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4631
enhrx-49223	chr14	38085624	38085625	37616419	37616420	10057	hg38	N/A	enh92521	N/A	Enhatls53123	enhancer	E4633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19376	0.87462		TTC6	chr14	37595628	37842717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-130451	chr5	1771488	1771489	1771373	1771374	10058	hg38	N/A	N/A	N/A	Enhatls139455	enhancer	E4634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10105	0.87517		MRPL36	chr5	1798384	1801366	18535	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	242
enhrx-27972	chr11	36562709	36562710	36541159	36541160	10059	hg38	N/A	enh103510	N/A	Enhatls30443	enhancer	E4635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066302	0.87563		RAG1	chr11	36510371	36579762	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2641
enhrx-94583	chr2	121180055	121180056	120422479	120422480	10060	hg38	N/A	N/A	N/A	Enhatls101277	enhancer	E4636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078734	0.87567		INHBB	chr2	120346135	120351803	54177	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-162837	chr9	1460354	1460355	1460354	1460355	10061	hg38	N/A	enh59925	N/A	Enhatls173904	enhancer	E4637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13259	0.87567		DMRT2	chr9	1049857	1057552	399016	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	104
enhrx-20156	chr10	51994471	51994472	50234711	50234712	10062	hg38	N/A	N/A	N/A	"Enhatls22208,Enhatls22209,Enhatls22210,Enhatls21717,Enhatls22211,Enhatls22212,Enhatls22213,Enhatls21716"	enhancer	E4638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23677	0.87567		ASAH2	chr10	50182777	50279720	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2591
enhrx-20167	chr10	52261866	52261867	50502106	50502107	10063	hg38	N/A	enh13209	fant35659	Enhatls22224	enhancer	E4639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065342	0.8762		SGMS1	chr10	50305585	50623977	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2602
enhrx-137143	chr5	158022056	158022057	158595048	158595049	10064	hg38	N/A	enh49007	N/A	Enhatls146554	enhancer	E4640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015039	0.87664		EBF1	chr5	158695919	159099916	94553	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6934
enhrx-22911	chr10	101155783	101155784	99396026	99396027	10065	hg38	N/A	N/A	N/A	Enhatls25163	enhancer	E4641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29581	0.87664		CNNM1	chr10	99329355	99394330	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5346
enhrx-19315	chr10	34506658	34506659	34217730	34217731	10066	hg38	N/A	enh87751	N/A	Enhatls21110	enhancer	E4642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2074	0.87664		PARD3	chr10	34109559	34815325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1750
enhrx-106395	chr21	22611409	22611410	21239089	21239090	10067	hg38	N/A	N/A	N/A	Enhatls113758	enhancer	E4643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2148	0.87696		NCAM2	chr21	20998408	21543329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	278
enhrx-162837	chr9	1454379	1454380	1454379	1454380	10068	hg38	N/A	enh93780	N/A	Enhatls173904	enhancer	E4644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16526	0.8772		DMRT2	chr9	1049857	1057552	394194	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	104
enhrx-16861	chr1	236666545	236666546	236503245	236503246	10069	hg38	N/A	N/A	N/A	Enhatls18462	enhancer	E4645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21748	0.8777		EDARADD	chr1	236348256	236484930	13871	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16860
enhrx-96296	chr2	162882153	162882154	162025643	162025644	10070	hg38	N/A	enh53394	N/A	Enhatls103086	enhancer	E4646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072236	0.87778		DPP4	chr2	161992244	162074394	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8222
enhrx-7741	chr1	90825679	90825680	90360121	90360122	10071	hg38	N/A	enh103078	N/A	Enhatls8378	enhancer	E4647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14799	0.87778		ZNF326	chr1	89995109	90035533	319195	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7740
enhrx-23960	chr10	115742718	115742719	113982959	113982960	10072	hg38	N/A	enh13527	N/A	Enhatls26304	enhancer	E4648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12897	0.87778		ADRB1	chr10	114043865	114046904	42110	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6395
enhrx-11062	chr1	156074141	156074142	156104350	156104351	10073	hg38	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E4649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047673	0.87787		LMNA	chr1	156082577	156140081	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11061
enhrx-13789	chr1	195708601	195708602	195739471	195739472	10074	hg38	N/A	N/A	N/A	Enhatls15212	enhancer	E4650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020713	0.87787		KCNT2	chr1	196225778	196609225	463764	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13788
enhrx-47878	chr13	113824474	113824475	113170160	113170161	10075	hg38	N/A	N/A	N/A	Enhatls51700	enhancer	E4651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068606	0.87787		PROZ	chr13	113158647	113172386	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3500
enhrx-116480	chr3	72356172	72356173	72307021	72307022	10076	hg38	N/A	enh20694	N/A	Enhatls124657	enhancer	E4652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11332	0.87787		RYBP	chr3	72371824	72446621	61207	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4609
enhrx-125106	chr4	58329209	58329210	57463043	57463044	10077	hg38	N/A	N/A	N/A	Enhatls133853	enhancer	E4653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04924	0.87787		IGFBP7	chr4	57030772	57110385	335225	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2650
enhrx-47556	chr13	107254725	107254726	106602377	106602378	10078	hg38	N/A	enh51703	N/A	Enhatls51351	enhancer	E4654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10616	0.87787		ARGLU1	chr13	106541672	106568137	29421	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3178
enhrx-117548	chr3	112773578	112773579	113054731	113054732	10079	hg38	N/A	N/A	N/A	Enhatls125807	enhancer	E4655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15042	0.87849		NEPRO	chr3	113002443	113019733	34376	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5677
enhrx-105148	chr20	50016210	50016211	51399673	51399674	10080	hg38	N/A	enh19745	fant59113	Enhatls112453	enhancer	E4656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086242	0.87884		NFATC2	chr20	51386956	51562831	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3576
enhrx-105013	chr20	47796374	47796375	49179837	49179838	10081	hg38	N/A	enh70298	N/A	Enhatls112286	enhancer	E4657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021919	0.87884		STAU1	chr20	49113338	49188367	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3441
enhrx-154336	chr7	131076857	131076858	131392098	131392099	10082	hg38	N/A	enh93664	N/A	Enhatls164930	enhancer	E4658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027736	0.87892		MKLN1	chr7	131110095	131496632	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7148
enhrx-59630	chr15	101981261	101981262	101441056	101441057	10083	hg38	N/A	enh16481	N/A	Enhatls64204	enhancer	E4659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016511	0.87933		PCSK6	chr15	101289783	101489984	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6332
enhrx-149729	chr7	46472522	46472523	46432924	46432925	10084	hg38	N/A	enh84634	N/A	Enhatls160039	enhancer	E4660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19074	0.87933		IGFBP3	chr7	45912244	45921874	508854	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-116097	chr3	59233374	59233375	59247648	59247649	10085	hg38	N/A	enh35439	N/A	Enhatls124228	enhancer	E4661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038866	0.87952		CFAP20DC	chr3	58717364	59050084	183696	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4226
enhrx-134398	chr5	107646550	107646551	108310849	108310850	10086	hg38	N/A	N/A	N/A	Enhatls143567	enhancer	E4662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094045	0.87955		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4189
enhrx-74255	chr17	71211833	71211834	73215694	73215695	10087	hg38	N/A	enh69316	N/A	Enhatls79718	enhancer	E4663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085945	0.87955		VCF1	chr17	73207352	73232394	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7524
enhrx-68113	chr17	8323859	8323860	8420541	8420542	10088	hg38	N/A	enh16966	N/A	Enhatls73111	enhancer	E4664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062501	0.87955		NDEL1	chr17	8413130	8490411	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1382
enhrx-16682	chr1	235133267	235133268	234997520	234997521	10089	hg38	N/A	enh997	fant5347	N/A	enhancer	E4665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.07103	0.87955		TOMM20	chr1	235109340	235128837	111678	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16681
enhrx-61284	chr16	14464626	14464627	14370769	14370770	10090	hg38	N/A	enh3905	N/A	Enhatls65876	enhancer	E4666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017194	0.88039		PARN	chr16	14435699	14632728	57299	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1579
enhrx-126198	chr4	82114038	82114039	81192884	81192885	10091	hg38	N/A	N/A	N/A	Enhatls135012	enhancer	E4667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22718	0.88085		PRKG2	chr4	81087369	81215222	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3742
enhrx-96229	chr2	161503772	161503773	160647261	160647262	10092	hg38	N/A	enh18961	N/A	Enhatls103014	enhancer	E4668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13353	0.88085		RBMS1	chr2	160272150	160493807	147648	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8155
enhrx-4724	chr1	41807942	41807943	41342270	41342271	10093	hg38	N/A	enh11784	N/A	Enhatls5185	enhancer	E4669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2246	0.88127		FOXO6	chr1	41361930	41382681	12368	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4723
enhrx-88778	chr2	18061367	18061368	17880100	17880101	10094	hg38	N/A	N/A	N/A	Enhatls95114	enhancer	E4670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13569	0.88127		KCNS3	chr2	17877846	17932958	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	704
enhrx-6772	chr1	68345921	68345922	67880238	67880239	10095	hg38	N/A	enh26825	N/A	Enhatls7372	enhancer	E4671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099484	0.88127		GNG12	chr1	67701474	67833467	42936	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6771
enhrx-112455	chr3	11701908	11701909	11660434	11660435	10096	hg38	N/A	enh20327	N/A	Enhatls120334	enhancer	E4672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11128	0.88174		VGLL4	chr3	11556068	11771350	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	584
enhrx-11670	chr1	160214215	160214216	160244425	160244426	10097	hg38	N/A	N/A	N/A	Enhatls12951	enhancer	E4673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10674	0.88174		DCAF8	chr1	160215714	160262549	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11669
enhrx-106336	chr21	18909784	18909785	17537466	17537467	10098	hg38	N/A	enh59102	N/A	Enhatls113694	enhancer	E4674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10772	0.88174		CXADR	chr21	17513042	17593579	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	219
enhrx-35142	chr12	5694787	5694788	5585621	5585622	10099	hg38	N/A	enh14482	N/A	Enhatls38136	enhancer	E4675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02831	0.88174		ANO2	chr12	5562650	5946232	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	452
enhrx-160675	chr8	102465106	102465107	101452878	101452879	10100	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E4676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064541	0.88174		GRHL2	chr8	101492438	101669726	37377	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-161645	chr8	128845492	128845493	127833246	127833247	10101	hg38	N/A	enh10528	N/A	Enhatls172652	enhancer	E4677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09327	0.88174		MYC	chr8	127735433	127742951	89186	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5436
enhrx-167487	chr9	116982587	116982588	114220307	114220308	10102	hg38	N/A	N/A	N/A	Enhatls179251	enhancer	E4678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19596	0.88183		COL27A1	chr9	114155536	114312511	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4754
enhrx-32389	chr11	97927877	97927878	98057149	98057150	10103	hg38	N/A	N/A	N/A	Enhatls35172	enhancer	E4679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16181	0.88183		CNTN5	chr11	99020948	100358885	951028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7058
enhrx-127415	chr4	109636699	109636700	108715543	108715544	10104	hg38	N/A	enh97525	N/A	Enhatls136275	enhancer	E4680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080084	0.88183		ETNPPL	chr4	108742047	108763053	24989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4959
enhrx-153497	chr7	114775994	114775995	115135940	115135941	10105	hg38	N/A	enh84789	N/A	Enhatls164023	enhancer	E4681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11554	0.88202		MDFIC	chr7	114922093	115019917	113295	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6309
enhrx-160680	chr8	102576207	102576208	101563979	101563980	10106	hg38	N/A	enh58009	N/A	Enhatls171627	enhancer	E4682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050892	0.88202		GRHL2	chr8	101492438	101669726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4471
enhrx-156037	chr7	156724723	156724724	156932029	156932030	10107	hg38	N/A	enh61528	N/A	Enhatls166705	enhancer	E4683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046015	0.88202		NOM1	chr7	156949711	156973176	17605	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8849
enhrx-122897	chr4	2909798	2909799	2908071	2908072	10108	hg38	N/A	N/A	N/A	Enhatls131504	enhancer	E4684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.41619	0.88202		ADD1	chr4	2843843	2930076	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	441
enhrx-47535	chr13	104582428	104582429	103930078	103930079	10109	hg38	N/A	N/A	N/A	Enhatls51326	enhancer	E4685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27912	0.88202		SLC10A2	chr13	103043997	103066417	819989	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3157
enhrx-59310	chr15	93383496	93383497	92840266	92840267	10110	hg38	N/A	enh3814	N/A	Enhatls63861	enhancer	E4686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10966	0.88202		FAM174B	chr15	92617447	92809798	23501	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6012
enhrx-23737	chr10	112186140	112186141	110426382	110426383	10111	hg38	N/A	enh1501	N/A	Enhatls26055	enhancer	E4687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.076631	0.88202		DUSP5	chr10	110497906	110511533	71239	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6172
enhrx-161142	chr8	116673918	116673919	115661691	115661692	10112	hg38	N/A	N/A	N/A	Enhatls172100	enhancer	E4688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12529	0.88245		TRPS1	chr8	115408495	115809673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4933
enhrx-146777	chr6	161763277	161763278	161342245	161342246	10113	hg38	N/A	N/A	N/A	Enhatls156896	enhancer	E4689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.063001	0.88254		PRKN	chr6	161347416	162727771	4624	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8365
enhrx-99581	chr2	217622457	217622458	216757734	216757735	10114	hg38	N/A	enh99776	N/A	Enhatls106541	enhancer	E4690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26774	0.88291		IGFBP5	chr2	216672104	216695549	60362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11507
enhrx-130467	chr5	2675388	2675389	2675274	2675275	10115	hg38	N/A	N/A	N/A	Enhatls139471	enhancer	E4691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0047693	0.88291		IRX2	chr5	2745844	2751677	62278	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	258
enhrx-145107	chr6	130835024	130835025	130513879	130513880	10116	hg38	N/A	enh39479	N/A	Enhatls155062	enhancer	E4692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18581	0.88322		TMEM200A	chr6	130366016	130443067	66874	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6695
enhrx-4237	chr1	36874267	36874268	36408666	36408667	10117	hg38	N/A	enh11740	N/A	Enhatls4670	enhancer	E4693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.057317	0.88322		OSCP1	chr1	36415826	36450451	3539	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4236
enhrx-19614	chr10	44968788	44968789	44473340	44473341	10118	hg38	N/A	enh28040	N/A	Enhatls21420	enhancer	E4694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037577	0.88335		CXCL12	chr10	44370164	44385097	83660	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2049
enhrx-27590	chr11	30444619	30444620	30423072	30423073	10119	hg38	N/A	enh64443	N/A	Enhatls30040	enhancer	E4695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.008458	0.88366		MPPED2	chr11	30384492	30586872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2259
enhrx-57222	chr15	67749513	67749514	67457175	67457176	10120	hg38	N/A	N/A	N/A	Enhatls61562	enhancer	E4696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034586	0.88366		IQCH	chr15	67254785	67502260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3924
enhrx-21512	chr10	80288758	80288759	78529001	78529002	10121	hg38	N/A	enh67553	N/A	Enhatls23668	enhancer	E4697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.037518	0.8842		RPS24	chr10	78033759	78056813	462236	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-113297	chr3	32358771	32358772	32317279	32317280	10122	hg38	N/A	enh54057	N/A	Enhatls121227	enhancer	E4698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017506	0.88444		CMTM8	chr3	32238678	32370321	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1426
enhrx-137187	chr5	159219384	159219385	159792377	159792378	10123	hg38	N/A	N/A	N/A	Enhatls146606	enhancer	E4699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039022	0.88445		ADRA1B	chr5	159865079	159973012	69362	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6978
enhrx-135591	chr5	134460102	134460103	135124412	135124413	10124	hg38	N/A	enh8707	N/A	Enhatls144849	enhancer	E4700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042876	0.88445		PITX1	chr5	135027733	135034813	81663	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5382
enhrx-88790	chr2	19190954	19190955	19009681	19009682	10125	hg38	N/A	N/A	N/A	Enhatls95126	enhancer	E4701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28693	0.8847		OSR1	chr2	19351484	19358623	337508	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	716
enhrx-15405	chr1	214489981	214489982	214316638	214316639	10126	hg38	N/A	N/A	N/A	Enhatls16932	enhancer	E4702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019699	0.8847		SMYD2	chr1	214281158	214337131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15404
enhrx-166609	chr9	101812944	101812945	99050662	99050663	10127	hg38	N/A	N/A	N/A	Enhatls178327	enhancer	E4703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080406	0.8847		COL15A1	chr9	98943712	99070792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3876
enhrx-123492	chr4	14855362	14855363	14853738	14853739	10128	hg38	N/A	enh45640	N/A	Enhatls132164	enhancer	E4704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16134	0.8847		CPEB2	chr4	15002480	15070153	146488	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1036
enhrx-160422	chr8	98375936	98375937	97363708	97363709	10129	hg38	N/A	enh25143	N/A	Enhatls171357	enhancer	E4705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071001	0.8847		TSPYL5	chr8	97273487	97277928	81890	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4213
enhrx-9364	chr1	116073360	116073361	115530739	115530740	10130	hg38	N/A	enh58144	N/A	Enhatls10103	enhancer	E4706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035241	0.88483		VANGL1	chr1	115641969	115698224	108356	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9363
enhrx-50968	chr14	72113955	72113956	71647238	71647239	10131	hg38	N/A	enh15748	N/A	Enhatls54969	enhancer	E4707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25067	0.88532		SIPA1L1	chr14	71320475	71741229	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2925
enhrx-156438	chr8	6460197	6460198	6602676	6602677	10132	hg38	N/A	enh24707	N/A	Enhatls167110	enhancer	E4708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16745	0.88556		MCPH1	chr8	6406591	6648508	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	229
enhrx-137143	chr5	157987435	157987436	158560427	158560428	10133	hg38	N/A	enh97785	N/A	Enhatls146554	enhancer	E4709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.021362	0.8857		EBF1	chr5	158695919	159099916	133393	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6934
enhrx-49852	chr14	55240198	55240199	54773480	54773481	10134	hg38	N/A	enh15630	N/A	Enhatls53789	enhancer	E4710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20778	0.8857		SAMD4A	chr14	54567127	54793315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1809
enhrx-64954	chr16	68309755	68309756	68275852	68275853	10135	hg38	N/A	enh4105	N/A	Enhatls69713	enhancer	E4711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1119	0.8857		SLC7A6	chr16	68264515	68301823	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5249
enhrx-131155	chr5	32249915	32249916	32249809	32249810	10136	hg38	N/A	N/A	N/A	Enhatls140186	enhancer	E4712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17225	0.8857		MTMR12	chr5	32226993	32312969	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	946
enhrx-159084	chr8	61167108	61167109	60254549	60254550	10137	hg38	N/A	enh89238	N/A	Enhatls169935	enhancer	E4713	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.07698	0.88603		CA8	chr8	60185411	60281400	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2875
enhrx-37639	chr12	45654195	45654196	45260412	45260413	10138	hg38	N/A	enh14663	fant41515	Enhatls40755	enhancer	E4714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054467	0.88604		ANO6	chr12	45216019	45440404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2949
enhrx-57677	chr15	74002624	74002625	73710283	73710284	10139	hg38	N/A	N/A	N/A	Enhatls62048	enhancer	E4715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070614	0.88672		CD276	chr15	73683965	73714514	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4379
enhrx-4309	chr1	38119837	38119838	37654165	37654166	10140	hg38	N/A	N/A	N/A	Enhatls4751	enhancer	E4716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11697	0.88672		RSPO1	chr1	37611349	37634892	5037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4308
enhrx-72779	chr17	49707510	49707511	51630149	51630150	10141	hg38	N/A	N/A	N/A	Enhatls78134	enhancer	E4717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014619	0.88672		CA10	chr17	51630312	52160017	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6048
enhrx-34586	chr11	133429453	133429454	133559558	133559559	10142	hg38	N/A	N/A	N/A	Enhatls37528	enhancer	E4718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079565	0.88685		OPCML	chr11	132414976	133532501	15357	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9255
enhrx-150346	chr7	66977892	66977893	67512905	67512906	10143	hg38	N/A	N/A	N/A	Enhatls160722	enhancer	E4719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.006617	0.88685		SPDYE21	chr7	67276940	67289005	197764	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3158
enhrx-59310	chr15	93347574	93347575	92804344	92804345	10144	hg38	N/A	enh16425	fant49388	Enhatls63861	enhancer	E4720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22263	0.88685		FAM174B	chr15	92617447	92809798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6012
enhrx-19954	chr10	49749350	49749351	48541305	48541306	10145	hg38	N/A	enh102411	N/A	Enhatls21915	enhancer	E4721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026316	0.88687		ARHGAP22	chr10	48446035	48652616	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2389
enhrx-8875	chr1	110548746	110548747	110006124	110006125	10146	hg38	N/A	enh109343	N/A	Enhatls9575	enhancer	E4722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.040405	0.88739		AHCYL1	chr1	109984764	110023742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8874
enhrx-166961	chr9	110820562	110820563	108058281	108058282	10147	hg38	N/A	enh25873	N/A	Enhatls178703	enhancer	E4723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083237	0.88739		KLF4	chr9	107484851	107490482	567148	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-155447	chr7	148903371	148903372	149206279	149206280	10148	hg38	N/A	enh24622	N/A	Enhatls166082	enhancer	E4724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19145	0.88916		ZNF282	chr7	149195545	149226238	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8259
enhrx-166174	chr9	96671591	96671592	93909309	93909310	10149	hg38	N/A	N/A	N/A	Enhatls177851	enhancer	E4725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13863	0.88916		BARX1	chr9	93951626	93955355	40664	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3441
enhrx-68071	chr17	8140551	8140552	8237233	8237234	10150	hg38	N/A	N/A	N/A	Enhatls73067	enhancer	E4726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.013499	0.88928		CTC1	chr17	8224814	8248058	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1340
enhrx-56360	chr15	57789453	57789454	57497255	57497256	10151	hg38	N/A	enh52022	N/A	Enhatls60639	enhancer	E4727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077184	0.88949		CGNL1	chr15	57376504	57550717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3062
enhrx-110004	chr22	34256393	34256394	33860405	33860406	10152	hg38	N/A	N/A	N/A	Enhatls117715	enhancer	E4728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12499	0.88949		LARGE1	chr22	33162225	33922841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1835
enhrx-49855	chr14	55306597	55306598	54839879	54839880	10153	hg38	N/A	enh3206	N/A	Enhatls53794	enhancer	E4729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016779	0.88949		GCH1	chr14	54842007	54902826	91	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1812
enhrx-138927	chr6	12411443	12411444	12411211	12411212	10154	hg38	N/A	N/A	N/A	Enhatls148526	enhancer	E4730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17505	0.88994		EDN1	chr6	12290360	12297194	106579	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	515
enhrx-69511	chr17	26852279	26852280	28525261	28525262	10155	hg38	N/A	N/A	N/A	Enhatls74616	enhancer	E4731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0025884	0.88994		FOXN1	chr17	28506242	28538900	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2780
enhrx-134396	chr5	107420020	107420021	108084319	108084320	10156	hg38	N/A	enh22483	N/A	Enhatls143565	enhancer	E4732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13285	0.88994		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4187
enhrx-33297	chr11	114592348	114592349	114721626	114721627	10157	hg38	N/A	N/A	N/A	Enhatls36130	enhancer	E4733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099333	0.88994		NXPE2	chr11	114678526	114707069	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7966
enhrx-41288	chr12	100602894	100602895	100209116	100209117	10158	hg38	N/A	N/A	N/A	Enhatls44625	enhancer	E4734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0056996	0.88994		ACTR6	chr12	100199121	100224424	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6598
enhrx-127240	chr4	105492592	105492593	104571435	104571436	10159	hg38	N/A	enh71347	N/A	Enhatls136089	enhancer	E4735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.030697	0.89035		CXXC4	chr4	104468307	104494894	74475	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4784
enhrx-40283	chr12	72374463	72374464	71980683	71980684	10160	hg38	N/A	enh68174	N/A	Enhatls43548	enhancer	E4736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089976	0.89035		TPH2	chr12	71938844	72032440	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5593
enhrx-176424	chrX	133861618	133861619	134727588	134727589	10161	hg38	N/A	enh26449	N/A	Enhatls188647	enhancer	E4737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015247	0.89035		PABIR2	chrX	134769565	134797232	39081	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6141
enhrx-27682	chr11	32500136	32500137	32478590	32478591	10162	hg38	N/A	enh64448	N/A	Enhatls30129	enhancer	E4738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12179	0.89044		WT1	chr11	32387774	32435564	40353	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2351
enhrx-82204	chr19	15408406	15408407	15297595	15297596	10163	hg38	N/A	enh5025	N/A	Enhatls88144	enhancer	E4739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043434	0.89044		BRD4	chr19	15235518	15332545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3174
enhrx-78009	chr18	47395907	47395908	49869537	49869538	10164	hg38	N/A	N/A	N/A	Enhatls83693	enhancer	E4740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24586	0.89053		MYO5B	chr18	49822788	50195147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2027
enhrx-27474	chr11	26605274	26605275	26583727	26583728	10165	hg38	N/A	enh13846	N/A	Enhatls29922	enhancer	E4741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12604	0.89053		ANO3	chr11	26188841	26663289	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2143
enhrx-112159	chr3	9236384	9236385	9194700	9194701	10166	hg38	N/A	enh82420	N/A	Enhatls120024	enhancer	E4742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19512	0.89053		SRGAP3	chr3	8980590	9249646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	288
enhrx-30909	chr11	70891215	70891216	71180169	71180170	10167	hg38	N/A	enh50878	N/A	Enhatls33604	enhancer	E4743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070929	0.89053		SHANK2	chr11	70467853	71252577	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5578
enhrx-143378	chr6	88263213	88263214	87553495	87553496	10168	hg38	N/A	N/A	N/A	Enhatls153250	enhancer	E4744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17355	0.89079		RARS2	chr6	87513762	87590028	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4966
enhrx-148226	chr7	17640136	17640137	17600512	17600513	10169	hg38	N/A	enh24010	N/A	Enhatls158404	enhancer	E4745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053315	0.89079		SNX13	chr7	17790760	17940494	188270	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1038
enhrx-91273	chr2	62241501	62241502	62014366	62014367	10170	hg38	N/A	enh44798	N/A	Enhatls97791	enhancer	E4746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0082624	0.8911		COMMD1	chr2	61905673	62147247	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3199
enhrx-138489	chr6	2565926	2565927	2565692	2565693	10171	hg38	N/A	enh84071	N/A	Enhatls148051	enhancer	E4747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073812	0.8911		MYLK4	chr6	2663628	2770330	95848	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	77
enhrx-94583	chr2	121238830	121238831	120481254	120481255	10172	hg38	N/A	N/A	N/A	Enhatls101279	enhancer	E4748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2437	0.89137		INHBB	chr2	120346135	120351803	126557	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-167566	chr9	117320801	117320802	114558521	114558522	10173	hg38	N/A	enh85511	N/A	Enhatls179334	enhancer	E4749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050448	0.89203		ATP6V1G1	chr9	114587705	114598879	25611	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4833
enhrx-147199	chr7	294447	294448	254481	254482	10174	hg38	N/A	N/A	N/A	Enhatls157311	enhancer	E4750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048608	0.89203		FAM20C	chr7	192570	260772	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11
enhrx-102701	chr20	19110972	19110973	19130328	19130329	10175	hg38	N/A	enh6305	N/A	Enhatls109807	enhancer	E4751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.052525	0.89203		SLC24A3	chr20	19212641	19722926	79171	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1129
enhrx-37544	chr12	43138456	43138457	42744654	42744655	10176	hg38	N/A	enh29534	N/A	Enhatls40659	enhancer	E4752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054173	0.89209		PRICKLE1	chr12	42456756	42590355	143677	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2854
enhrx-116482	chr3	72772289	72772290	72723138	72723139	10177	hg38	N/A	enh20705	N/A	Enhatls124659	enhancer	E4753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22468	0.89209		SHQ1	chr3	72749276	72861914	17873	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-26182	chr11	6455428	6455429	6434198	6434199	10178	hg38	N/A	enh60281	N/A	Enhatls28538	enhancer	E4754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034673	0.89209		HPX	chr11	6431048	6440987	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	851
enhrx-21716	chr10	87071903	87071904	85312147	85312148	10179	hg38	N/A	enh101219	N/A	Enhatls23903	enhancer	E4755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040297	0.89209		GRID1	chr10	85599551	86366795	285533	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4151
enhrx-47015	chr13	94774719	94774720	94122465	94122466	10180	hg38	N/A	enh51647	N/A	Enhatls50769	enhancer	E4756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17576	0.89217		GPC6	chr13	93226806	94408020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2637
enhrx-76657	chr18	12741488	12741489	12741489	12741490	10181	hg38	N/A	enh32480	N/A	Enhatls82260	enhancer	E4757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058117	0.89217		PSMG2	chr18	12658737	12728945	10987	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	675
enhrx-99357	chr2	213821533	213821534	212956809	212956810	10182	hg38	N/A	enh19182	N/A	Enhatls106294	enhancer	E4758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039684	0.89224		IKZF2	chr2	212999690	213152427	41922	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11283
enhrx-45078	chr13	30498253	30498254	29924116	29924117	10183	hg38	N/A	enh15194	N/A	Enhatls48628	enhancer	E4759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12211	0.89316		UBL3	chr13	29764370	29850617	68457	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	700
enhrx-154865	chr7	139749168	139749169	140049368	140049369	10184	hg38	N/A	enh56511	N/A	Enhatls165492	enhancer	E4760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1279	0.89321		PARP12	chr7	140023748	140062951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7677
enhrx-47683	chr13	111208332	111208333	110555985	110555986	10185	hg38	N/A	enh15501	N/A	Enhatls51502	enhancer	E4761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062707	0.89321		RAB20	chr13	110523065	110561722	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3305
enhrx-164138	chr9	34688797	34688798	34688800	34688801	10186	hg38	N/A	N/A	N/A	Enhatls175259	enhancer	E4762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19947	0.89321		CCL19	chr9	34689569	34691276	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1405
enhrx-115633	chr3	53179572	53179573	53145556	53145557	10187	hg38	N/A	enh82532	N/A	Enhatls123712	enhancer	E4763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20842	0.89321		PRKCD	chr3	53156008	53192717	6690	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3762
enhrx-150372	chr7	70716879	70716880	71251893	71251894	10188	hg38	N/A	enh72812	N/A	Enhatls160751	enhancer	E4764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086009	0.89321		GALNT17	chr7	71132143	71713599	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3184
enhrx-9162	chr1	113798145	113798146	113255523	113255524	10189	hg38	N/A	enh12160	N/A	Enhatls9894	enhancer	E4765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050041	0.89328		LRIG2	chr1	113073197	113132260	118964	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9161
enhrx-51747	chr14	87778641	87778642	87312297	87312298	10190	hg38	N/A	enh3384	N/A	Enhatls55808	enhancer	E4766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1507	0.89383		GALC	chr14	87933013	87993665	616583	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3704
enhrx-21050	chr10	73610434	73610435	71850677	71850678	10191	hg38	N/A	N/A	N/A	Enhatls23173	enhancer	E4767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12087	0.89417		PSAP	chr10	71816297	71851251	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3485
enhrx-100167	chr2	225774863	225774864	224910146	224910147	10192	hg38	N/A	enh45014	fant10308	Enhatls107161	enhancer	E4768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.072234	0.8943		DOCK10	chr2	224765089	225042468	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12093
enhrx-139214	chr6	21104040	21104041	21103809	21103810	10193	hg38	N/A	enh23107	N/A	Enhatls148829	enhancer	E4769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0038195	0.8943		CDKAL1	chr6	20534456	21232404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	802
enhrx-163834	chr9	27689131	27689132	27689133	27689134	10194	hg38	N/A	N/A	N/A	Enhatls174947	enhancer	E4770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15733	0.8943		C9orf72	chr9	27546545	27573866	93532	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1101
enhrx-93894	chr2	110437400	110437401	109679823	109679824	10195	hg38	N/A	enh18799	N/A	Enhatls100565	enhancer	E4771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045322	0.89466		SOWAHC	chr2	109614363	109618990	53979	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5820
enhrx-136179	chr5	142120238	142120239	142740673	142740674	10196	hg38	N/A	enh22664	N/A	N/A	enhancer	E4772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0066596	0.89466		ARHGAP26	chr5	142770376	143229011	24662	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5970
enhrx-21701	chr10	86122115	86122116	84362359	84362360	10197	hg38	N/A	enh96121	N/A	Enhatls23886	enhancer	E4773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085967	0.89526		CCSER2	chr10	84328585	84518521	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4136
enhrx-163686	chr9	22455446	22455447	22455447	22455448	10198	hg38	N/A	N/A	N/A	Enhatls174785	enhancer	E4774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0090073	0.89526		DMRTA1	chr9	22446823	22455740	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	953
enhrx-24666	chr10	124964765	124964766	123205249	123205250	10199	hg38	N/A	enh43445	fant37264	Enhatls27036	enhancer	E4775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17994	0.89526		BUB3	chr10	123154401	123170467	34686	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7101
enhrx-77818	chr18	43632160	43632161	46052194	46052195	10200	hg38	N/A	enh32658	fant55023	Enhatls83491	enhancer	E4776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031906	0.89526		PSTPIP2	chr18	45983535	46072260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1836
enhrx-135082	chr5	127271252	127271253	127935560	127935561	10201	hg38	N/A	N/A	N/A	Enhatls144302	enhancer	E4777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15385	0.89526		CCDC192	chr5	127703360	127941507	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4873
enhrx-50260	chr14	61132029	61132030	60665311	60665312	10202	hg38	N/A	N/A	N/A	Enhatls54217	enhancer	E4778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11357	0.89526		SIX1	chr14	60643420	60658259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2217
enhrx-138483	chr6	2167134	2167135	2166900	2166901	10203	hg38	N/A	enh38723	N/A	Enhatls148043	enhancer	E4779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054853	0.89526		GMDS	chr6	1623805	2245605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	71
enhrx-38658	chr12	53280695	53280696	52886911	52886912	10204	hg38	N/A	enh14733	N/A	Enhatls41825	enhancer	E4780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21672	0.89527		KRT8	chr12	52897186	52949882	5506	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3968
enhrx-116238	chr3	64136742	64136743	64151066	64151067	10205	hg38	N/A	enh20659	fant12350	Enhatls124378	enhancer	E4781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19595	0.89566		PRICKLE2	chr3	64092235	64445407	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4367
enhrx-144001	chr6	107150601	107150602	106702726	106702727	10206	hg38	N/A	enh9282	N/A	Enhatls153881	enhancer	E4782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02294	0.89569		QRSL1	chr6	106629577	106668417	30674	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5589
enhrx-44915	chr13	27552616	27552617	26978479	26978480	10207	hg38	N/A	enh15170	N/A	Enhatls48454	enhancer	E4783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02452	0.89569		USP12	chr13	27066155	27171811	87538	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	537
enhrx-139234	chr6	22363583	22363584	22363354	22363355	10208	hg38	N/A	enh49062	N/A	Enhatls148858	enhancer	E4784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10522	0.89577		PRL	chr6	22287243	22302826	55411	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	822
enhrx-36854	chr12	27156970	27156971	27004037	27004038	10209	hg38	N/A	enh2241	N/A	Enhatls39947	enhancer	E4785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.029651	0.89577		TM7SF3	chr12	26971578	27014434	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-40934	chr12	93784066	93784067	93390290	93390291	10210	hg38	N/A	enh60400	N/A	Enhatls44241	enhancer	E4786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086802	0.89597		NUDT4	chr12	93377882	93408146	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6244
enhrx-132477	chr5	63219932	63219933	63924105	63924106	10211	hg38	N/A	enh97681	N/A	Enhatls141580	enhancer	E4787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083707	0.89597		HTR1A	chr5	63957873	63962507	31706	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2268
enhrx-21961	chr10	90945632	90945633	89185875	89185876	10212	hg38	N/A	enh96124	N/A	Enhatls24169	enhancer	E4788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16865	0.89597		CH25H	chr10	89205628	89207317	17691	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4396
enhrx-156454	chr8	6710045	6710046	6852523	6852524	10213	hg38	N/A	enh24714	N/A	Enhatls167129	enhancer	E4789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051418	0.89597		DEFB1	chr8	6870591	6877936	6131	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	245
enhrx-27662	chr11	32082710	32082711	32061164	32061165	10214	hg38	N/A	N/A	N/A	Enhatls30109	enhancer	E4790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15238	0.89597		RCN1	chr11	32091073	32105722	27115	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2331
enhrx-93694	chr2	106332751	106332752	105716294	105716295	10215	hg38	N/A	enh33549	N/A	Enhatls100344	enhancer	E4791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097047	0.89656		NCK2	chr2	105744911	105894274	27234	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5620
enhrx-97310	chr2	178619429	178619430	177754701	177754702	10216	hg38	N/A	enh19049	N/A	Enhatls104148	enhancer	E4792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039447	0.89663		PDE11A	chr2	177623243	178108339	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9236
enhrx-27853	chr11	34338734	34338735	34317187	34317188	10217	hg38	N/A	enh13884	N/A	Enhatls30312	enhancer	E4793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083107	0.89663		ABTB2	chr11	34150986	34358010	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2522
enhrx-145174	chr6	131973133	131973134	131651993	131651994	10218	hg38	N/A	N/A	N/A	Enhatls155130	enhancer	E4794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17673	0.89687		ENPP3	chr6	131628460	131747418	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6762
enhrx-46665	chr13	76007269	76007270	75433133	75433134	10219	hg38	N/A	enh64736	N/A	Enhatls50386	enhancer	E4795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25905	0.89687		TBC1D4	chr13	75283502	75482169	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2287
enhrx-55396	chr15	44535483	44535484	44243285	44243286	10220	hg38	N/A	N/A	N/A	Enhatls59612	enhancer	E4796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13291	0.89687		GOLM2	chr15	44288718	44415758	15472	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2098
enhrx-952	chr1	8031308	8031309	7971248	7971249	10221	hg38	N/A	N/A	N/A	Enhatls1007	enhancer	E4797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12647	0.89687		PARK7	chr1	7954290	7985505	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	951
enhrx-3081	chr1	26624882	26624883	26298391	26298392	10222	hg38	N/A	N/A	N/A	Enhatls3427	enhancer	E4798	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013017	0.89687		UBXN11	chr1	26281327	26318363	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3080
enhrx-160459	chr8	99081046	99081047	98068818	98068819	10223	hg38	N/A	enh25149	N/A	Enhatls171399	enhancer	E4799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11121	0.89687		ERICH5	chr8	98064521	98093610	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4250
enhrx-24737	chr10	126366647	126366648	124678078	124678079	10224	hg38	N/A	enh1579	N/A	Enhatls27082	enhancer	E4800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15452	0.89687		FAM53B	chr10	124619291	124744378	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7172
enhrx-6863	chr1	70710661	70710662	70244978	70244979	10225	hg38	N/A	N/A	N/A	Enhatls7468	enhancer	E4801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10767	0.89687		SRSF11	chr1	70205681	70253052	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6862
enhrx-5320	chr1	46781547	46781548	46315875	46315876	10226	hg38	N/A	N/A	N/A	Enhatls5829	enhancer	E4802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1144	0.89687		UQCRH	chr1	46303697	46316776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5319
enhrx-147426	chr7	2451985	2451986	2412350	2412351	10227	hg38	N/A	enh23924	N/A	Enhatls157551	enhancer	E4803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24319	0.89694		CHST12	chr7	2403587	2448484	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	238
enhrx-175994	chrX	121497651	121497652	122363798	122363799	10228	hg38	N/A	enh98382	N/A	Enhatls188198	enhancer	E4804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14079	0.89734		GRIA3	chrX	123184152	123490915	818291	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5711
enhrx-149985	chr7	51331433	51331434	51263736	51263737	10229	hg38	N/A	enh24194	N/A	Enhatls160322	enhancer	E4805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16077	0.8979		COBL	chr7	51016211	51316818	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2797
enhrx-28983	chr11	59041021	59041022	59273548	59273549	10230	hg38	N/A	enh1795	N/A	Enhatls31505	enhancer	E4806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23492	0.8979		MPEG1	chr11	59208509	59212927	60143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3652
enhrx-148127	chr7	15169482	15169483	15129857	15129858	10231	hg38	N/A	enh39900	N/A	Enhatls158298	enhancer	E4807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098706	0.8979		AGMO	chr7	15200316	15562015	67387	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	939
enhrx-167627	chr9	118758922	118758923	115996643	115996644	10232	hg38	N/A	enh25943	fant33456	Enhatls179404	enhancer	E4808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061989	0.89797		PAPPA	chr9	116153790	116402321	157037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4894
enhrx-102912	chr20	23567881	23567882	23587244	23587245	10233	hg38	N/A	enh53734	fant58264	Enhatls110037	enhancer	E4809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086723	0.89797		CST9	chr20	23602409	23605917	15072	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1340
enhrx-123919	chr4	26024094	26024095	26022472	26022473	10234	hg38	N/A	enh36483	N/A	Enhatls132609	enhancer	E4810	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.023841	0.89838		SMIM20	chr4	25914219	25929813	85841	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1463
enhrx-111103	chr22	43390090	43390091	42994084	42994085	10235	hg38	N/A	enh20238	N/A	Enhatls118890	enhancer	E4811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16594	0.89838		PACSIN2	chr22	42869767	43015149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2934
enhrx-129439	chr4	167856193	167856194	166935042	166935043	10236	hg38	N/A	N/A	N/A	Enhatls138366	enhancer	E4812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028753	0.89838		SPOCK3	chr4	166733383	167234796	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6983
enhrx-116467	chr3	71707476	71707477	71658325	71658326	10237	hg38	N/A	enh48716	N/A	Enhatls124637	enhancer	E4813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12181	0.89838		EIF4E3	chr3	71675413	71754773	10490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4596
enhrx-147817	chr7	6500084	6500085	6460453	6460454	10238	hg38	N/A	enh39856	N/A	Enhatls157967	enhancer	E4814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12641	0.89838		DAGLB	chr7	6409128	6484190	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	629
enhrx-29457	chr11	62275899	62275900	62508427	62508428	10239	hg38	N/A	enh13974	N/A	Enhatls32009	enhancer	E4815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12122	0.89838		AHNAK	chr11	62433541	62556235	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4126
enhrx-88307	chr2	8712257	8712258	8572127	8572128	10240	hg38	N/A	enh5280	fant5870	Enhatls94583	enhancer	E4816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13634	0.89838		ID2	chr2	8678844	8684461	106695	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	233
enhrx-110130	chr22	36861427	36861428	36465380	36465381	10241	hg38	N/A	enh6845	N/A	Enhatls117854	enhancer	E4817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.046383	0.8985		TXN2	chr22	36467045	36481640	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1961
enhrx-59309	chr15	93210600	93210601	92667370	92667371	10242	hg38	N/A	enh16423	N/A	Enhatls63860	enhancer	E4818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11714	0.8985		FAM174B	chr15	92617447	92809798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6011
enhrx-144090	chr6	109028872	109028873	108707669	108707670	10243	hg38	N/A	enh97905	N/A	Enhatls153977	enhancer	E4819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044084	0.8985		FOXO3	chr6	108559834	108684774	20629	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5678
enhrx-100976	chr2	237654546	237654547	236745903	236745904	10244	hg38	N/A	enh19379	fant10704	Enhatls108013	enhancer	E4820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088083	0.89854		ACKR3	chr2	236567786	236582354	163359	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12902
enhrx-15823	chr1	223524039	223524040	223350697	223350698	10245	hg38	N/A	N/A	N/A	Enhatls17369	enhancer	E4821	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0205	0.89854		SUSD4	chr1	223220818	223364233	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15822
enhrx-47183	chr13	98531044	98531045	97878790	97878791	10246	hg38	N/A	enh30593	N/A	Enhatls50947	enhancer	E4822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21179	0.89854		IPO5	chr13	97953657	98024296	70277	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2805
enhrx-126733	chr4	90226344	90226345	89305193	89305194	10247	hg38	N/A	enh8088	N/A	Enhatls135564	enhancer	E4823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14235	0.89854		GPRIN3	chr4	89236382	89307800	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4277
enhrx-62279	chr16	23336382	23336383	23325061	23325062	10248	hg38	N/A	N/A	N/A	Enhatls66907	enhancer	E4824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19774	0.89904		SCNN1B	chr16	23302301	23381294	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2574
enhrx-115166	chr3	50483465	50483466	50446034	50446035	10249	hg38	N/A	enh48694	N/A	Enhatls123214	enhancer	E4825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035114	0.89904		CACNA2D2	chr3	50362612	50504244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3295
enhrx-99574	chr2	217416075	217416076	216551352	216551353	10250	hg38	N/A	enh34250	N/A	Enhatls106529	enhancer	E4826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01422	0.8991		RPL37A	chr2	216498843	216579180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11500
enhrx-47827	chr13	113567902	113567903	112913588	112913589	10251	hg38	N/A	enh92501	N/A	Enhatls51652	enhancer	E4827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1358	0.8991		MCF2L	chr13	112894377	113099742	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3449
enhrx-95180	chr2	134658677	134658678	133901106	133901107	10252	hg38	N/A	N/A	N/A	Enhatls101913	enhancer	E4828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015499	0.8991		MGAT5	chr2	134120181	134454621	172437	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7106
enhrx-108003	chr21	47454018	47454019	46034104	46034105	10253	hg38	N/A	enh20047	N/A	Enhatls115514	enhancer	E4829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12389	0.8991		COL6A1	chr21	45981769	46005048	26864	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1886
enhrx-34364	chr11	126252694	126252695	126382799	126382800	10254	hg38	N/A	enh14375	N/A	Enhatls37275	enhancer	E4830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14212	0.89924		ST3GAL4	chr11	126355659	126414638	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9033
enhrx-19533	chr10	43521962	43521963	43026514	43026515	10255	hg38	N/A	enh96066	N/A	Enhatls21325	enhancer	E4831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073322	0.89924		RET	chr10	43077068	43130351	48382	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1968
enhrx-28896	chr11	57547038	57547039	57779566	57779567	10256	hg38	N/A	enh13938	N/A	Enhatls31418	enhancer	E4832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065753	0.89924		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-134635	chr5	114001426	114001427	114665729	114665730	10257	hg38	N/A	N/A	N/A	Enhatls143820	enhancer	E4833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22285	0.89924		KCNN2	chr5	114055977	114496500	164039	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4426
enhrx-144761	chr6	122942218	122942219	122621073	122621074	10258	hg38	N/A	enh84381	N/A	Enhatls154704	enhancer	E4834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14017	0.89982		PKIB	chr6	122471916	122726373	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6349
enhrx-74234	chr17	70948764	70948765	72952625	72952626	10259	hg38	N/A	enh75940	N/A	Enhatls79698	enhancer	E4835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048217	0.89982		SLC39A11	chr17	72645948	73092712	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7503
enhrx-145492	chr6	137347854	137347855	137026717	137026718	10260	hg38	N/A	enh23653	N/A	Enhatls155502	enhancer	E4836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02821	0.90006		IL20RA	chr6	136999970	137045180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7080
enhrx-147972	chr7	8130349	8130350	8090719	8090720	10261	hg38	N/A	N/A	N/A	Enhatls158132	enhancer	E4837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0037774	0.90006		GLCCI1	chr7	7968795	8089080	16	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	784
enhrx-58151	chr15	78516538	78516539	78224196	78224197	10262	hg38	N/A	enh62504	N/A	Enhatls62567	enhancer	E4838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12989	0.90029		ACSBG1	chr15	78167467	78245688	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4853
enhrx-68582	chr17	14229256	14229257	14325939	14325940	10263	hg38	N/A	enh17014	N/A	Enhatls73598	enhancer	E4839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088579	0.9009		HS3ST3B1	chr17	14301080	14349404	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1851
enhrx-72924	chr17	55660542	55660543	57583181	57583182	10264	hg38	N/A	enh4491	N/A	Enhatls78283	enhancer	E4840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21792	0.9009		MSI2	chr17	57255850	57684689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6193
enhrx-130049	chr4	186489128	186489129	185567974	185567975	10265	hg38	hs2502	enh22000	N/A	Enhatls139031	enhancer	E4841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17594	0.9009		SORBS2	chr4	185585443	185956652	13966	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7593
enhrx-8028	chr1	94583858	94583859	94118302	94118303	10266	hg38	N/A	enh12069	fant2426	Enhatls8700	enhancer	E4842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.012434	0.90091		ABCA4	chr1	93992833	94121148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8027
enhrx-59417	chr15	98437620	98437621	97894390	97894391	10267	hg38	N/A	N/A	N/A	Enhatls63984	enhancer	E4843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031394	0.90091		ARRDC4	chr15	97960702	97973833	60528	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6119
enhrx-107109	chr21	38219125	38219126	36846825	36846826	10268	hg38	N/A	enh34922	N/A	Enhatls114529	enhancer	E4844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24836	0.90091		HLCS	chr21	36748625	36990236	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	992
enhrx-97926	chr2	190351237	190351238	189486511	189486512	10269	hg38	N/A	enh19083	N/A	Enhatls104780	enhancer	E4845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0025116	0.90098		WDR75	chr2	189441473	189475552	3148	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-59308	chr15	93181614	93181615	92638384	92638385	10270	hg38	N/A	enh16422	N/A	Enhatls63859	enhancer	E4846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049768	0.90152		FAM174B	chr15	92617447	92809798	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6010
enhrx-149195	chr7	36985815	36985816	36946210	36946211	10271	hg38	N/A	enh66389	N/A	Enhatls159465	enhancer	E4847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089362	0.90152		ELMO1	chr7	36852905	37449223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2007
enhrx-24669	chr10	125503637	125503638	123744121	123744122	10272	hg38	N/A	enh13593	N/A	Enhatls27039	enhancer	E4848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11769	0.90152		CPXM2	chr10	123713275	123891984	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7104
enhrx-24755	chr10	126635657	126635658	124947088	124947089	10273	hg38	N/A	enh64394	N/A	Enhatls27105	enhancer	E4849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13379	0.90152		ZRANB1	chr10	124942122	124988189	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7190
enhrx-148285	chr7	19939331	19939332	19899708	19899709	10274	hg38	N/A	enh84556	N/A	Enhatls158466	enhancer	E4850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.049933	0.90152		TMEM196	chr7	19719314	19773617	124066	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1097
enhrx-158373	chr8	40231011	40231012	40373492	40373493	10275	hg38	N/A	enh24949	N/A	Enhatls169206	enhancer	E4851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0047203	0.90165		ZMAT4	chr8	40530589	40897833	153788	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2164
enhrx-32130	chr11	92440490	92440491	92707324	92707325	10276	hg38	N/A	enh28988	N/A	Enhatls34899	enhancer	E4852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033382	0.90183		FAT3	chr11	92224817	92896473	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6799
enhrx-46203	chr13	51096102	51096103	50521966	50521967	10277	hg38	N/A	enh2877	N/A	Enhatls49880	enhancer	E4853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11004	0.90198		DLEU7	chr13	50711900	50843939	185957	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1825
enhrx-177018	chrX	149862961	149862962	150694488	150694489	10278	hg38	N/A	enh47113	N/A	Enhatls189268	enhancer	E4854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087046	0.90198		MTMR1	chrX	150692970	150765108	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6735
enhrx-15108	chr1	208472180	208472181	208298835	208298836	10279	hg38	N/A	enh109381	N/A	Enhatls16628	enhancer	E4855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077927	0.90208		PLXNA2	chr1	208022241	208244384	52297	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15107
enhrx-98429	chr2	200489864	200489865	199625141	199625142	10280	hg38	N/A	enh97040	N/A	Enhatls105308	enhancer	E4856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043691	0.90305		FTCDNL1	chr2	199760543	199851192	133292	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10355
enhrx-14721	chr1	205447366	205447367	205478238	205478239	10281	hg38	N/A	enh61954	N/A	Enhatls16210	enhancer	E4857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18634	0.90305		BLACAT1	chr1	205434884	205457091	18413	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14720
enhrx-121805	chr3	187068645	187068646	187350857	187350858	10282	hg38	N/A	enh54534	N/A	Enhatls130354	enhancer	E4858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22028	0.90328		RTP4	chr3	187368384	187372076	12776	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9934
enhrx-111103	chr22	43322172	43322173	42926166	42926167	10283	hg38	N/A	enh20236	N/A	Enhatls118887	enhancer	E4859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086371	0.90328		PACSIN2	chr22	42869767	43015149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2934
enhrx-31827	chr11	84148716	84148717	84437673	84437674	10284	hg38	N/A	N/A	N/A	Enhatls34581	enhancer	E4860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062011	0.90339		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6496
enhrx-123166	chr4	6055207	6055208	6053480	6053481	10285	hg38	N/A	N/A	N/A	Enhatls131799	enhancer	E4861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10789	0.90343		C4orf50	chr4	5957117	6200555	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	710
enhrx-123166	chr4	6055207	6055208	6053480	6053481	10286	hg38	N/A	N/A	N/A	Enhatls131799	enhancer	E4861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10789	0.90343		JAKMIP1	chr4	6026198	6200591	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	710
enhrx-134394	chr5	107205664	107205665	107869963	107869964	10287	hg38	N/A	enh38216	N/A	Enhatls143563	enhancer	E4862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071121	0.90343		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4185
enhrx-124555	chr4	47674091	47674092	47672074	47672075	10288	hg38	N/A	N/A	N/A	Enhatls133282	enhancer	E4863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10602	0.90343		CORIN	chr4	47593998	47838106	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2099
enhrx-61606	chr16	17410046	17410047	17316189	17316190	10289	hg38	N/A	enh3921	N/A	Enhatls66215	enhancer	E4864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17029	0.90363		XYLT1	chr16	17101768	17470960	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1901
enhrx-49217	chr14	37854682	37854683	37385477	37385478	10290	hg38	N/A	N/A	N/A	Enhatls53118	enhancer	E4865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05157	0.9038		MIPOL1	chr14	37197893	37564746	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1174
enhrx-129175	chr4	158236262	158236263	157315110	157315111	10291	hg38	N/A	N/A	N/A	Enhatls138099	enhancer	E4866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081776	0.9038		GRIA2	chr4	157219902	157366075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6719
enhrx-98949	chr2	206767005	206767006	205902281	205902282	10292	hg38	N/A	enh53529	N/A	Enhatls105874	enhancer	E4867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23504	0.9046		INO80D	chr2	205993720	206086303	87710	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10875
enhrx-123969	chr4	28844095	28844096	28842473	28842474	10293	hg38	N/A	N/A	N/A	Enhatls132667	enhancer	E4868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10514	0.90485		STIM2	chr4	26857677	27025381	1794948	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1513
enhrx-107185	chr21	39009004	39009005	37636702	37636703	10294	hg38	N/A	enh34926	N/A	Enhatls114617	enhancer	E4869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087398	0.90485		KCNJ6	chr21	37607372	38121345	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1068
enhrx-90579	chr2	45993218	45993219	45766079	45766080	10295	hg38	N/A	enh65261	N/A	Enhatls97038	enhancer	E4870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18354	0.90517		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2505
enhrx-45302	chr13	34298056	34298057	33723919	33723920	10296	hg38	N/A	enh2764	N/A	Enhatls48902	enhancer	E4871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10754	0.90517		RFC3	chr13	33818068	33966558	89241	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	924
enhrx-2275	chr1	19756904	19756905	19430410	19430411	10297	hg38	N/A	enh99	N/A	Enhatls2533	enhancer	E4872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14461	0.90517		CAPZB	chr1	19338774	19485539	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2274
enhrx-58283	chr15	79507388	79507389	79215046	79215047	10298	hg38	N/A	N/A	N/A	Enhatls62709	enhancer	E4873	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23691	0.90517		ANKRD34C	chr15	79282721	79298239	66161	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4985
enhrx-46702	chr13	76410839	76410840	75836703	75836704	10299	hg38	N/A	N/A	N/A	Enhatls50425	enhancer	E4874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054289	0.90547		LMO7	chr13	75620433	75859870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2324
enhrx-123492	chr4	14227486	14227487	14225862	14225863	10300	hg38	N/A	enh54599	N/A	Enhatls132164	enhancer	E4875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042368	0.90547		BOD1L1	chr4	13568737	13627725	587797	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1036
enhrx-116819	chr3	97381671	97381672	97662827	97662828	10301	hg38	N/A	enh70754	N/A	Enhatls125008	enhancer	E4876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042971	0.90549		EPHA6	chr3	96814580	97761532	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4948
enhrx-24347	chr10	121545774	121545775	119786262	119786263	10302	hg38	N/A	enh13565	fant37202	Enhatls26714	enhancer	E4877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15049	0.90549		INPP5F	chr10	119726049	119829147	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6782
enhrx-135003	chr5	125874991	125874992	126539299	126539300	10303	hg38	N/A	N/A	N/A	Enhatls144219	enhancer	E4878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25815	0.90574		ALDH7A1	chr5	126531199	126595336	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4794
enhrx-57461	chr15	71902367	71902368	71610028	71610029	10304	hg38	N/A	enh58661	N/A	Enhatls61825	enhancer	E4879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16732	0.90617		THSD4	chr15	71096951	71783383	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4163
enhrx-163467	chr9	18393950	18393951	18393952	18393953	10305	hg38	N/A	enh41773	N/A	Enhatls174552	enhancer	E4880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27307	0.90645		ADAMTSL1	chr9	17906562	18910950	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	734
enhrx-134718	chr5	115760825	115760826	116425128	116425129	10306	hg38	N/A	N/A	N/A	Enhatls143908	enhancer	E4881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17639	0.90645		SEMA6A	chr5	116443554	116574823	8586	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4509
enhrx-172129	chrX	43553312	43553313	43694065	43694066	10307	hg38	N/A	enh26245	N/A	Enhatls184172	enhancer	E4882	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037445	0.90646		MAOA	chrX	43654906	43746817	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1846
enhrx-120485	chr3	160760192	160760193	161042404	161042405	10308	hg38	N/A	enh36060	N/A	Enhatls128917	enhancer	E4883	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049743	0.9075		PPM1L	chr3	160755601	161078902	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8614
enhrx-131700	chr5	40493008	40493009	40492906	40492907	10309	hg38	N/A	N/A	N/A	Enhatls140778	enhancer	E4884	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16827	0.90766		TTC33	chr5	40512332	40755963	16650	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1491
enhrx-40479	chr12	79926873	79926874	79533093	79533094	10310	hg38	N/A	enh29761	N/A	Enhatls43754	enhancer	E4885	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1558	0.90766		PAWR	chr12	79584878	79690964	48584	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5789
enhrx-148204	chr7	16887073	16887074	16847449	16847450	10311	hg38	N/A	enh24002	fant25644	Enhatls158377	enhancer	E4886	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.068023	0.9081		AGR3	chr7	16859411	16881987	11563	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1016
enhrx-110130	chr22	36831028	36831029	36434983	36434984	10312	hg38	N/A	enh6845	N/A	Enhatls117854	enhancer	E4887	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10469	0.9081		TXN2	chr22	36467045	36481640	17023	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1961
enhrx-58136	chr15	78420389	78420390	78128047	78128048	10313	hg38	N/A	enh96606	N/A	Enhatls62547	enhancer	E4888	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087224	0.9081		CIB2	chr15	78104605	78131535	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4838
enhrx-154133	chr7	128603080	128603081	128963026	128963027	10314	hg38	N/A	enh24498	N/A	Enhatls164706	enhancer	E4889	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28919	0.9081		TNPO3	chr7	128954179	129055173	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6945
enhrx-58365	chr15	81172527	81172528	80880186	80880187	10315	hg38	N/A	N/A	N/A	Enhatls62787	enhancer	E4890	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.037205	0.9086		CEMIP	chr15	80779342	80951776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5067
enhrx-21455	chr10	79131794	79131795	77372036	77372037	10316	hg38	N/A	enh79673	N/A	Enhatls23603	enhancer	E4891	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31326	0.9086		KCNMA1	chr10	76869600	77638369	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-86823	chr19	51555562	51555563	51052305	51052306	10317	hg38	N/A	N/A	N/A	Enhatls93050	enhancer	E4892	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10276	0.90894		KLK13	chr19	51055625	51065114	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7793
enhrx-107031	chr21	37565743	37565744	36193445	36193446	10318	hg38	N/A	enh19939	N/A	Enhatls114446	enhancer	E4893	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088653	0.90894		DOP1B	chr21	36156823	36294274	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	914
enhrx-41818	chr12	106628585	106628586	106234807	106234808	10319	hg38	N/A	enh29960	N/A	Enhatls45190	enhancer	E4894	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10254	0.90902		CKAP4	chr12	106237880	106304279	1104	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-117740	chr3	115541627	115541628	115822780	115822781	10320	hg38	N/A	enh35805	N/A	Enhatls126012	enhancer	E4895	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15998	0.90934		LSAMP	chr3	115802373	117139389	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5869
enhrx-78325	chr18	55764626	55764627	58097394	58097395	10321	hg38	N/A	enh4868	N/A	Enhatls84027	enhancer	E4896	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029738	0.90934		NEDD4L	chr18	58044225	58401540	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2343
enhrx-72923	chr17	55592180	55592181	57514819	57514820	10322	hg38	N/A	enh4489	N/A	Enhatls78278	enhancer	E4897	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22395	0.90934		MSI2	chr17	57255850	57684689	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6192
enhrx-40951	chr12	94451688	94451689	94057912	94057913	10323	hg38	N/A	enh29878	N/A	Enhatls44266	enhancer	E4898	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068695	0.90972		PLXNC1	chr12	94148576	94307675	83078	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6261
enhrx-92381	chr2	85738516	85738517	85511393	85511394	10324	hg38	N/A	enh18703	N/A	Enhatls98978	enhancer	E4899	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16216	0.90972		MAT2A	chr2	85539167	85545281	19876	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-78929	chr18	74967591	74967592	77255635	77255636	10325	hg38	N/A	N/A	N/A	Enhatls84680	enhancer	E4900	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13992	0.90974		GALR1	chr18	77249847	77277900	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2947
enhrx-158108	chr8	37947577	37947578	38090059	38090060	10326	hg38	N/A	enh24928	N/A	Enhatls168922	enhancer	E4901	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.015029	0.90985		ASH2L	chr8	38105492	38144076	13769	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1899
enhrx-42919	chr12	117945538	117945539	117507733	117507734	10327	hg38	N/A	enh109576	N/A	Enhatls46349	enhancer	E4902	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.016127	0.91021		KSR2	chr12	117453011	117968990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8229
enhrx-37139	chr12	31926577	31926578	31773643	31773644	10328	hg38	N/A	enh14624	N/A	Enhatls40247	enhancer	E4903	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17506	0.91056		H3-5	chr12	31791184	31792298	15004	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2449
enhrx-143586	chr6	90930216	90930217	90220497	90220498	10329	hg38	N/A	enh23420	N/A	Enhatls153465	enhancer	E4904	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15055	0.91074		BACH2	chr6	89926527	90296843	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5174
enhrx-61080	chr16	10289022	10289023	10195165	10195166	10330	hg38	N/A	N/A	N/A	Enhatls65658	enhancer	E4905	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20834	0.91112		GRIN2A	chr16	9753403	10182897	4857	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1375
enhrx-46988	chr13	91855909	91855910	91203655	91203656	10331	hg38	N/A	enh15412	N/A	Enhatls50739	enhancer	E4906	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13426	0.91138		GPC5	chr13	91398620	92873682	186995	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2610
enhrx-72571	chr17	48394740	48394741	50317379	50317380	10332	hg38	N/A	enh58763	N/A	Enhatls77911	enhancer	E4907	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077503	0.91138		XYLT2	chr17	50346125	50363138	22548	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5840
enhrx-100001	chr2	221824438	221824439	220959718	220959719	10333	hg38	N/A	enh34292	N/A	Enhatls106993	enhancer	E4908	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15867	0.91163		EPHA4	chr2	221418026	221574202	446372	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11927
enhrx-161197	chr8	119042123	119042124	118029884	118029885	10334	hg38	N/A	enh25239	N/A	Enhatls172165	enhancer	E4909	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016022	0.91163		EXT1	chr8	117794489	118111826	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4988
enhrx-159560	chr8	71863779	71863780	70951544	70951545	10335	hg38	N/A	enh73321	N/A	Enhatls170438	enhancer	E4910	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26997	0.91163		XKR9	chr8	70669338	70735942	208961	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3351
enhrx-14587	chr1	204349790	204349791	204380662	204380663	10336	hg38	N/A	N/A	fant4418	Enhatls16060	enhancer	E4911	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.35148	0.9119		PLEKHA6	chr1	204218852	204377665	2776	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14586
enhrx-89678	chr2	30440897	30440898	30218031	30218032	10337	hg38	N/A	enh5384	fant6464	Enhatls96063	enhancer	E4912	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27903	0.9119		LBH	chr2	30231533	30323730	13489	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1604
enhrx-26456	chr11	9098368	9098369	9076821	9076822	10338	hg38	N/A	enh43484	N/A	Enhatls28842	enhancer	E4913	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.024849	0.9119		SCUBE2	chr11	9019475	9091601	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1125
enhrx-45835	chr13	45468744	45468745	44894609	44894610	10339	hg38	N/A	enh15280	N/A	Enhatls49473	enhancer	E4914	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054688	0.91206		NUFIP1	chr13	44939248	44989471	40889	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1457
enhrx-131041	chr5	24073474	24073475	24073365	24073366	10340	hg38	N/A	enh83630	N/A	Enhatls140062	enhancer	E4915	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11984	0.91225		CDH10	chr5	24487099	24644978	411674	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	832
enhrx-80598	chr19	7480710	7480711	7415824	7415825	10341	hg38	N/A	enh17893	N/A	Enhatls86459	enhancer	E4916	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13066	0.91242		ARHGEF18	chr19	7348936	7472485	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1568
enhrx-124698	chr4	48701675	48701676	48699658	48699659	10342	hg38	N/A	enh21502	N/A	Enhatls133428	enhancer	E4917	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10172	0.91242		FRYL	chr4	48497356	48780279	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2242
enhrx-46202	chr13	50932064	50932065	50357928	50357929	10343	hg38	N/A	enh2870	fant44544	Enhatls49876	enhancer	E4918	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0063723	0.91242		KCNRG	chr13	50015253	50020922	336705	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1824
enhrx-1610	chr1	14336374	14336375	14009879	14009880	10344	hg38	N/A	enh103000	N/A	Enhatls1786	enhancer	E4919	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025227	0.91242		KAZN	chr1	13892791	15118043	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1609
enhrx-44902	chr13	27176016	27176017	26601879	26601880	10345	hg38	N/A	enh30142	N/A	Enhatls48441	enhancer	E4920	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083984	0.9127		WASF3	chr13	26557682	26688948	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	524
enhrx-137676	chr5	173090078	173090079	173663075	173663076	10346	hg38	N/A	enh61329	N/A	Enhatls147145	enhancer	E4921	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32353	0.91276		BOD1	chr5	173607144	173616653	44390	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7467
enhrx-108507	chr22	19531746	19531747	19544223	19544224	10347	hg38	N/A	enh97215	N/A	Enhatls116039	enhancer	E4922	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17231	0.91276		CLDN5	chr22	19523023	19527545	14458	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	338
enhrx-95929	chr2	153718109	153718110	152861595	152861596	10348	hg38	N/A	N/A	N/A	Enhatls102694	enhancer	E4923	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10982	0.91322		ARL6IP6	chr2	152717646	152762396	67826	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7855
enhrx-53659	chr15	26084193	26084194	25839046	25839047	10349	hg38	N/A	N/A	N/A	Enhatls57815	enhancer	E4924	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13112	0.91322		ATP10A	chr15	25677272	25865172	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	361
enhrx-130157	chr4	188157948	188157949	187236794	187236795	10350	hg38	N/A	enh22015	N/A	Enhatls139142	enhancer	E4925	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.020659	0.91322		FAT1	chr4	186587793	186726722	503610	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7701
enhrx-143583	chr6	90650312	90650313	89940593	89940594	10351	hg38	N/A	enh49121	N/A	Enhatls153461	enhancer	E4926	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13149	0.91348		BACH2	chr6	89926527	90296843	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5171
enhrx-97211	chr2	176326772	176326773	175462044	175462045	10352	hg38	N/A	N/A	N/A	Enhatls104046	enhancer	E4928	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031941	0.91348		ATP5MC3	chr2	175176257	175181710	252518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9137
enhrx-136194	chr5	142520640	142520641	143141075	143141076	10353	hg38	N/A	enh38463	N/A	Enhatls145506	enhancer	E4929	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.026315	0.91407		ARHGAP26	chr5	142770376	143229011	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5985
enhrx-131050	chr5	24547441	24547442	24547332	24547333	10354	hg38	N/A	N/A	N/A	Enhatls140071	enhancer	E4930	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13614	0.91407		CDH10	chr5	24487099	24644978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	841
enhrx-41815	chr12	106254529	106254530	105860751	105860752	10355	hg38	N/A	enh43808	N/A	Enhatls45183	enhancer	E4931	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.048221	0.91416		NUAK1	chr12	106063344	106138954	198568	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7125
enhrx-75622	chr17	79551142	79551143	81584116	81584117	10356	hg38	N/A	enh32380	N/A	Enhatls81161	enhancer	E4932	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22946	0.91416		NPLOC4	chr17	81556886	81637112	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8891
enhrx-103879	chr20	35184963	35184964	36556560	36556561	10357	hg38	N/A	enh94456	N/A	Enhatls111101	enhancer	E4933	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12824	0.9145		MYL9	chr20	36541496	36551447	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2307
enhrx-173484	chrX	68500937	68500938	69281094	69281095	10358	hg38	N/A	enh47042	N/A	Enhatls185652	enhancer	E4934	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084741	0.9145		PJA1	chrX	69160850	69165521	109176	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3201
enhrx-21417	chr10	77325282	77325283	75565524	75565525	10359	hg38	N/A	N/A	N/A	Enhatls23561	enhancer	E4935	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.063521	0.9145		LRMDA	chr10	75431623	76560168	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3852
enhrx-148747	chr7	29495911	29495912	29456295	29456296	10360	hg38	N/A	enh46336	N/A	Enhatls158968	enhancer	E4936	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0605	0.91451		CHN2	chr7	29194425	29514328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1559
enhrx-131255	chr5	34487605	34487606	34487500	34487501	10361	hg38	N/A	enh22111	N/A	Enhatls140295	enhancer	E4937	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080428	0.91452		RAI14	chr5	34656327	34832612	162029	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1046
enhrx-148704	chr7	28185713	28185714	28146094	28146095	10362	hg38	N/A	enh102966	N/A	Enhatls158920	enhancer	E4938	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17314	0.91471		JAZF1	chr7	27830572	28180795	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1516
enhrx-47564	chr13	108129638	108129639	107477290	107477291	10363	hg38	N/A	N/A	N/A	Enhatls51360	enhancer	E4939	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081816	0.91492		NALF1	chr13	107163509	107867496	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3186
enhrx-166542	chr9	100985861	100985862	98223579	98223580	10364	hg38	N/A	enh25805	fant32982	Enhatls178252	enhancer	E4940	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24783	0.91496		TBC1D2	chr9	98199010	98255649	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3809
enhrx-8357	chr1	101448499	101448500	100982943	100982944	10365	hg38	N/A	N/A	N/A	Enhatls9048	enhancer	E4941	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0064505	0.91496		SLC30A7	chr1	100896075	100981757	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8356
enhrx-148676	chr7	27299988	27299989	27260369	27260370	10366	hg38	N/A	enh97988	N/A	Enhatls158890	enhancer	E4942	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25985	0.91519		EVX1	chr7	27242699	27247830	10437	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1488
enhrx-46634	chr13	74182475	74182476	73608338	73608339	10367	hg38	N/A	enh15389	N/A	Enhatls50350	enhancer	E4943	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071325	0.91519		KLF12	chr13	73686088	74134404	75432	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2256
enhrx-58915	chr15	89694312	89694313	89151081	89151082	10368	hg38	N/A	N/A	N/A	Enhatls63447	enhancer	E4944	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11094	0.91526		ABHD2	chr15	89087458	89202355	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5617
enhrx-101372	chr2	241940258	241940259	241000841	241000842	10369	hg38	N/A	N/A	N/A	Enhatls108421	enhancer	E4945	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021835	0.91543		SNED1	chr2	240998617	241095568	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13298
enhrx-98915	chr2	205048514	205048515	204183791	204183792	10370	hg38	N/A	enh70132	N/A	Enhatls105834	enhancer	E4946	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0968	0.91543		ICOS	chr2	203936762	203961577	211036	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10841
enhrx-149729	chr7	46017985	46017986	45978386	45978387	10371	hg38	N/A	enh24169	N/A	Enhatls160039	enhancer	E4947	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10446	0.91578		IGFBP3	chr7	45912244	45921874	48813	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2541
enhrx-76270	chr18	6107907	6107908	6107908	6107909	10372	hg38	N/A	N/A	N/A	Enhatls81846	enhancer	E4948	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20524	0.91578		L3MBTL4	chr18	5954705	6415237	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	288
enhrx-79660	chr19	2491701	2491702	2491703	2491704	10373	hg38	N/A	enh4958	N/A	Enhatls85463	enhancer	E4949	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10349	0.91598		GADD45B	chr19	2476126	2478257	11228	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	630
enhrx-40358	chr12	76353037	76353038	75959257	75959258	10374	hg38	N/A	enh2469	fant42338	Enhatls43628	enhancer	E4950	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13881	0.91599		PHLDA1	chr12	76025446	76031776	66033	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5668
enhrx-128465	chr4	141641989	141641990	140720835	140720836	10375	hg38	N/A	enh37112	N/A	Enhatls137368	enhancer	E4951	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26111	0.91599		TBC1D9	chr4	140620781	140756385	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6009
enhrx-102703	chr20	19408458	19408459	19427814	19427815	10376	hg38	N/A	enh45098	N/A	Enhatls109817	enhancer	E4952	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13348	0.91599		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1131
enhrx-26885	chr11	15729677	15729678	15708131	15708132	10377	hg38	N/A	enh50729	N/A	Enhatls29308	enhancer	E4953	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02824	0.91599		SOX6	chr11	15966448	16476388	256200	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1554
enhrx-119981	chr3	149282093	149282094	149564306	149564307	10378	hg38	N/A	enh21021	N/A	Enhatls128362	enhancer	E4954	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087154	0.91599		WWTR1	chr3	149517234	149703273	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8110
enhrx-102593	chr20	17659074	17659075	17678429	17678430	10379	hg38	N/A	enh19508	N/A	Enhatls109696	enhancer	E4955	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10319	0.91599		RRBP1	chr20	17613677	17682295	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1021
enhrx-153350	chr7	108487107	108487108	108846663	108846664	10380	hg38	N/A	N/A	N/A	Enhatls163872	enhancer	E4956	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20234	0.91599		DNAJB9	chr7	108569873	108574850	265282	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6162
enhrx-50688	chr14	67946938	67946939	67480221	67480222	10381	hg38	N/A	enh44014	N/A	Enhatls54666	enhancer	E4957	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051638	0.91599		TMEM229B	chr14	67470268	67533739	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2645
enhrx-42832	chr12	116559647	116559648	116121842	116121843	10382	hg38	N/A	enh30006	N/A	Enhatls46252	enhancer	E4958	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10996	0.91599		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8142
enhrx-2055	chr1	17738836	17738837	17412340	17412341	10383	hg38	N/A	N/A	N/A	Enhatls2303	enhancer	E4959	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013775	0.91599		RCC2	chr1	17406759	17439677	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2054
enhrx-30911	chr11	70995179	70995180	71284133	71284134	10384	hg38	N/A	enh14053	N/A	Enhatls33605	enhancer	E4960	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15421	0.9162		SHANK2	chr11	70467853	71252577	27483	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5580
enhrx-141993	chr6	51756798	51756799	51892000	51892001	10385	hg38	N/A	enh84198	N/A	Enhatls151800	enhancer	E4961	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13056	0.91624		PKHD1	chr6	51615298	52087613	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3581
enhrx-21849	chr10	89378791	89378792	87619034	87619035	10386	hg38	N/A	enh50536	N/A	Enhatls24056	enhancer	E4962	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.010099	0.91624		PAPSS2	chr10	87659612	87747705	30956	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4284
enhrx-73032	chr17	56452950	56452951	58375589	58375590	10387	hg38	N/A	enh4499	N/A	Enhatls78401	enhancer	E4963	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054422	0.91648		RNF43	chr17	58353675	58417582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6301
enhrx-44513	chr13	20982577	20982578	20408438	20408439	10388	hg38	N/A	enh96384	N/A	Enhatls48025	enhancer	E4964	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061445	0.91648		CRYL1	chr13	20403666	20525873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	135
enhrx-88628	chr2	12008345	12008346	11868219	11868220	10389	hg38	N/A	enh5293	N/A	Enhatls94944	enhancer	E4965	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.017666	0.91648		LPIN1	chr2	11677594	11827409	31291	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	554
enhrx-37221	chr12	38543320	38543321	38149518	38149519	10390	hg38	N/A	enh14646	N/A	Enhatls40332	enhancer	E4966	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00129	0.91648		ALG10B	chr12	38316761	38329721	164201	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2531
enhrx-28844	chr11	57245491	57245492	57478018	57478019	10391	hg38	N/A	N/A	N/A	Enhatls31358	enhancer	E4967	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11435	0.91648		RTN4RL2	chr11	57460527	57477534	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3513
enhrx-68207	chr17	9110427	9110428	9207110	9207111	10392	hg38	N/A	enh52414	N/A	Enhatls73207	enhancer	E4968	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14885	0.91648		NTN1	chr17	9021509	9244000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1476
enhrx-158051	chr8	37097376	37097377	37239858	37239859	10393	hg38	N/A	enh84951	N/A	Enhatls168859	enhancer	E4969	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2729	0.91648		KCNU1	chr8	36784323	36936125	301603	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-150370	chr7	70253399	70253400	70788413	70788414	10394	hg38	N/A	N/A	fant26686	Enhatls160749	enhancer	E4970	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22321	0.91676		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3182
enhrx-41230	chr12	99423717	99423718	99029939	99029940	10395	hg38	N/A	enh2549	N/A	Enhatls44563	enhancer	E4971	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029211	0.91676		ANKS1B	chr12	98734683	99984936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6540
enhrx-113235	chr3	30300464	30300465	30258973	30258974	10396	hg38	N/A	enh35311	N/A	Enhatls121162	enhancer	E4972	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059896	0.91676		RBMS3	chr3	28576174	30010391	244144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1364
enhrx-33948	chr11	121121863	121121864	121251154	121251155	10397	hg38	N/A	enh29201	N/A	Enhatls36834	enhancer	E4973	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18263	0.91676		SC5D	chr11	121292770	121313410	32485	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8617
enhrx-99586	chr2	218252909	218252910	217388186	217388187	10398	hg38	N/A	enh34263	N/A	Enhatls106547	enhancer	E4974	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079242	0.91684		TNS1	chr2	217799587	218033982	409276	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11512
enhrx-167568	chr9	117351050	117351051	114588770	114588771	10399	hg38	N/A	N/A	fant33383	Enhatls179335	enhancer	E4975	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24229	0.91685		ATP6V1G1	chr9	114587705	114598879	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4835
enhrx-97752	chr2	186994892	186994893	186130165	186130166	10400	hg38	N/A	enh34030	N/A	Enhatls104603	enhancer	E4976	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22257	0.91685		FSIP2	chr2	185738803	185833290	290005	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9678
enhrx-1610	chr1	14825582	14825583	14499086	14499087	10401	hg38	N/A	enh49660	N/A	Enhatls1786	enhancer	E4977	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088815	0.91704		KAZN	chr1	13892791	15118043	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1609
enhrx-105043	chr20	47998187	47998188	49381650	49381651	10402	hg38	N/A	enh63003	N/A	Enhatls112317	enhancer	E4978	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0027806	0.91704		KCNB1	chr20	49298106	49484297	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3471
enhrx-123792	chr4	23376141	23376142	23374518	23374519	10403	hg38	N/A	enh54627	N/A	Enhatls132476	enhancer	E4979	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097097	0.91741		PPARGC1A	chr4	23792020	23890077	415349	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1336
enhrx-42830	chr12	116516429	116516430	116078624	116078625	10404	hg38	N/A	N/A	N/A	Enhatls46250	enhancer	E4980	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082571	0.91742		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8140
enhrx-106750	chr21	33724011	33724012	32351702	32351703	10405	hg38	N/A	N/A	N/A	Enhatls114139	enhancer	E4981	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13136	0.91792		URB1	chr21	32311017	32393012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	633
enhrx-28896	chr11	57530273	57530274	57762801	57762802	10406	hg38	N/A	enh98815	N/A	Enhatls31418	enhancer	E4982	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20222	0.91799		CTNND1	chr11	57753242	57819546	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3565
enhrx-113080	chr3	25471171	25471172	25429680	25429681	10407	hg38	N/A	N/A	N/A	Enhatls120997	enhancer	E4983	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03092	0.91844		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1209
enhrx-176424	chrX	133852530	133852531	134718500	134718501	10408	hg38	N/A	enh26449	N/A	Enhatls188647	enhancer	E4984	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23984	0.9196		PABIR2	chrX	134769565	134797232	39081	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6141
enhrx-150142	chr7	62483871	62483872	63023493	63023494	10409	hg38	N/A	N/A	N/A	Enhatls160490	enhancer	E4985	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33782	0.91968		ZNF722	chr7	63998848	64018081	848845	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2954
enhrx-90631	chr2	47184352	47184353	46957213	46957214	10410	hg38	N/A	N/A	N/A	Enhatls97098	enhancer	E4986	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079034	0.91993		TTC7A	chr2	46916156	47076123	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2557
enhrx-46265	chr13	52248617	52248618	51674481	51674482	10411	hg38	N/A	enh15346	N/A	Enhatls49954	enhancer	E4987	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39987	0.91993		WDFY2	chr13	51584454	51767709	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1887
enhrx-100922	chr2	235890277	235890278	234981633	234981634	10412	hg38	N/A	N/A	N/A	Enhatls107958	enhancer	E4988	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.083597	0.91993		SH3BP4	chr2	234952016	235055714	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12848
enhrx-17070	chr1	238274557	238274558	238111257	238111258	10413	hg38	N/A	enh67339	N/A	Enhatls18679	enhancer	E4989	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17182	0.91993		ZP4	chr1	237877863	237890922	219670	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17069
enhrx-7119	chr1	77913540	77913541	77447855	77447856	10414	hg38	N/A	enh79077	N/A	Enhatls7728	enhancer	E4990	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01769	0.91993		AK5	chr1	77282018	77559966	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7118
enhrx-100179	chr2	226511596	226511597	225646880	225646881	10415	hg38	N/A	N/A	N/A	Enhatls107173	enhancer	E4991	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.039785	0.91993		NYAP2	chr2	225399709	225729887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12105
enhrx-145936	chr6	148580188	148580189	148259052	148259053	10416	hg38	N/A	N/A	N/A	Enhatls155987	enhancer	E4992	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0011903	0.91993		SASH1	chr6	148342837	148552044	83334	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7524
enhrx-152692	chr7	101526657	101526658	101883377	101883378	10417	hg38	N/A	enh9948	N/A	Enhatls163184	enhancer	E4993	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0055676	0.92006		CUX1	chr7	101815903	102283958	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5504
enhrx-85917	chr19	47317464	47317465	46814207	46814208	10418	hg38	N/A	enh86329	N/A	Enhatls92088	enhancer	E4994	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18323	0.92006		SLC1A5	chr19	46774882	46788594	20151	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6887
enhrx-173190	chrX	56027486	56027487	56001053	56001054	10419	hg38	N/A	N/A	N/A	Enhatls185386	enhancer	E4995	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0068185	0.92006		RRAGB	chrX	55717748	55758774	166089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2907
enhrx-146430	chr6	158174482	158174483	157753450	157753451	10420	hg38	N/A	enh9495	N/A	Enhatls156515	enhancer	E4996	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096388	0.92067		SNX9	chr6	157700386	157945077	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8018
enhrx-95151	chr2	133236949	133236950	132479376	132479377	10421	hg38	N/A	enh109898	N/A	Enhatls101879	enhancer	E4997	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069652	0.92067		GPR39	chr2	132416804	132646582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7077
enhrx-54985	chr15	42411393	42411394	42119195	42119196	10422	hg38	N/A	enh51982	N/A	Enhatls59200	enhancer	E4998	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20789	0.92074		PLA2G4F	chr15	42139033	42156636	17141	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1687
enhrx-78811	chr18	71922458	71922459	74255223	74255224	10423	hg38	N/A	N/A	N/A	Enhatls84552	enhancer	E4999	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087316	0.92076		CYB5A	chr18	74250845	74291973	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2829
enhrx-46632	chr13	73833305	73833306	73259168	73259169	10424	hg38	N/A	enh51583	N/A	Enhatls50348	enhancer	E5000	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32381	0.92076		KLF5	chr13	73054975	73077541	179683	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2254
enhrx-116482	chr3	72795817	72795818	72746666	72746667	10425	hg38	N/A	enh54199	N/A	Enhatls124659	enhancer	E5001	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19357	0.92076		SHQ1	chr3	72749276	72861914	253	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-174752	chrX	99731208	99731209	100476210	100476211	10426	hg38	N/A	enh66802	N/A	Enhatls186928	enhancer	E5002	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39516	0.92076		PCDH19	chrX	100291643	100410273	65814	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4469
enhrx-33903	chr11	120686644	120686645	120815935	120815936	10427	hg38	N/A	N/A	N/A	Enhatls36788	enhancer	E5003	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15403	0.92076		GRIK4	chr11	120511745	120988906	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8572
enhrx-138689	chr6	7139397	7139398	7139164	7139165	10428	hg38	N/A	enh8942	N/A	Enhatls148272	enhancer	E5004	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.36201	0.92087		RREB1	chr6	7107596	7251980	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	277
enhrx-31716	chr11	78512601	78512602	78801556	78801557	10429	hg38	N/A	enh14142	fant39369	Enhatls34465	enhancer	E5005	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19742	0.92106		TENM4	chr11	78652828	79441030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6385
enhrx-63803	chr16	52631832	52631833	52597920	52597921	10430	hg38	N/A	enh92673	N/A	Enhatls68488	enhancer	E5006	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15551	0.92106		TOX3	chr16	52436416	52547802	47892	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4098
enhrx-123845	chr4	25204320	25204321	25202698	25202699	10431	hg38	N/A	N/A	N/A	Enhatls132534	enhancer	E5007	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14078	0.92168		PI4K2B	chr4	25160662	25279204	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1389
enhrx-136549	chr5	148963163	148963164	149583600	149583601	10432	hg38	N/A	enh22702	fant20325	Enhatls145882	enhancer	E5008	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090405	0.92179		ARHGEF37	chr5	149551946	149634968	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6340
enhrx-137677	chr5	173295272	173295273	173868269	173868270	10433	hg38	N/A	enh22827	N/A	Enhatls147152	enhancer	E5009	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13615	0.92179		CPEB4	chr5	173888348	173961980	15153	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7468
enhrx-130714	chr5	10539279	10539280	10539167	10539168	10434	hg38	N/A	enh88904	N/A	Enhatls139728	enhancer	E5010	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25142	0.92179		ANKRD33B	chr5	10564069	10657816	22787	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-33309	chr11	115791986	115791987	115921268	115921269	10435	hg38	N/A	enh2026	N/A	Enhatls36145	enhancer	E5011	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31389	0.92192		CADM1	chr11	115169235	115504957	412511	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7978
enhrx-82755	chr19	18140819	18140820	18030010	18030011	10436	hg38	N/A	enh44633	N/A	Enhatls88745	enhancer	E5012	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22501	0.92231		ARRDC2	chr19	18001131	18014102	13660	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3725
enhrx-82494	chr19	17133243	17133244	17022433	17022434	10437	hg38	N/A	enh17962	N/A	Enhatls88462	enhancer	E5013	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14956	0.92321		CPAMD8	chr19	16892950	17026810	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3464
enhrx-166917	chr9	108664094	108664095	105901813	105901814	10438	hg38	N/A	enh98281	N/A	Enhatls178652	enhancer	E5014	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0053036	0.92381		TMEM38B	chr9	105694540	105776629	123056	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4184
enhrx-55112	chr15	42964259	42964260	42672061	42672062	10439	hg38	N/A	N/A	N/A	Enhatls59329	enhancer	E5015	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058705	0.92381		STARD9	chr15	42575605	42720998	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1814
enhrx-158054	chr8	37410499	37410500	37552981	37552982	10440	hg38	N/A	enh24920	N/A	Enhatls168869	enhancer	E5016	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049078	0.92387		ZNF703	chr8	37695781	37700019	139705	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1845
enhrx-147988	chr7	8677835	8677836	8638205	8638206	10441	hg38	N/A	enh89080	N/A	Enhatls158151	enhancer	E5017	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060304	0.92412		NXPH1	chr7	8433608	8752961	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	800
enhrx-18150	chr10	13035809	13035810	12993809	12993810	10442	hg38	N/A	enh27814	N/A	Enhatls19838	enhancer	E5018	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0072783	0.92412		CCDC3	chr10	12896624	13099652	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	585
enhrx-30810	chr11	69895010	69895011	70048904	70048905	10443	hg38	N/A	enh14040	fant39107	Enhatls33500	enhancer	E5019	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16528	0.92412		ANO1	chr11	69985906	70189530	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5479
enhrx-75072	chr17	76195261	76195262	78199180	78199181	10444	hg38	N/A	N/A	fant53942	Enhatls80591	enhancer	E5020	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21371	0.9242		AFMID	chr17	78187357	78207702	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8341
enhrx-3425	chr1	28933498	28933499	28606986	28606987	10445	hg38	N/A	N/A	N/A	Enhatls3798	enhancer	E5021	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024306	0.9244		TAF12	chr1	28587828	28648291	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3424
enhrx-112117	chr3	8752079	8752080	8710393	8710394	10446	hg38	N/A	enh90169	N/A	Enhatls119980	enhancer	E5022	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039994	0.92465		SSUH2	chr3	8619385	8745036	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	246
enhrx-41170	chr12	97907731	97907732	97513953	97513954	10447	hg38	N/A	enh51360	N/A	Enhatls44499	enhancer	E5023	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097575	0.9247		NEDD1	chr12	96907223	96953780	558288	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6480
enhrx-45076	chr13	30415843	30415844	29841706	29841707	10448	hg38	N/A	enh68360	fant44005	Enhatls48624	enhancer	E5024	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.056646	0.9247		UBL3	chr13	29764370	29850617	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	698
enhrx-96477	chr2	166634892	166634893	165778382	165778383	10449	hg38	N/A	enh69986	N/A	Enhatls103273	enhancer	E5025	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047059	0.9247		GALNT3	chr2	165747587	165794659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8403
enhrx-119480	chr3	138564932	138564933	138846090	138846091	10450	hg38	N/A	enh20977	N/A	Enhatls127849	enhancer	E5026	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034043	0.9247		PIK3CB	chr3	138652697	138834928	8136	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7609
enhrx-166290	chr9	98803319	98803320	96041037	96041038	10451	hg38	N/A	enh46804	N/A	Enhatls177985	enhancer	E5027	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13723	0.92517		ERCC6L2	chr9	95871263	96018447	20377	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3557
enhrx-103500	chr20	32496321	32496322	33908515	33908516	10452	hg38	N/A	enh19590	N/A	Enhatls110661	enhancer	E5028	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14114	0.92568		CHMP4B	chr20	33811347	33854366	51974	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1928
enhrx-31747	chr11	81978442	81978443	82267400	82267401	10453	hg38	N/A	enh103560	N/A	Enhatls34495	enhancer	E5029	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28071	0.92568		FAM181B	chr11	82729939	82733864	459087	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6416
enhrx-109302	chr22	26945147	26945148	26549181	26549182	10454	hg38	N/A	enh6801	N/A	Enhatls116961	enhancer	E5030	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04384	0.92568		TPST2	chr22	26521995	26596717	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1133
enhrx-93434	chr2	101556179	101556180	100939717	100939718	10455	hg38	N/A	enh107806	N/A	Enhatls100067	enhancer	E5031	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050392	0.92568		NPAS2	chr2	100820138	100996829	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5360
enhrx-91959	chr2	74080950	74080951	73853823	73853824	10456	hg38	N/A	N/A	N/A	Enhatls98532	enhancer	E5032	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098649	0.92571		STAMBP	chr2	73828915	73873652	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3885
enhrx-65007	chr16	68812973	68812974	68779070	68779071	10457	hg38	N/A	enh16744	N/A	Enhatls69769	enhancer	E5033	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017141	0.92571		CDH1	chr16	68737291	68835537	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5302
enhrx-1515	chr1	12676118	12676119	12616114	12616115	10458	hg38	N/A	enh11516	N/A	Enhatls1638	enhancer	E5034	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26224	0.92573		DHRS3	chr1	12567909	12618210	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1514
enhrx-128686	chr4	147056081	147056082	146134929	146134930	10459	hg38	N/A	enh8262	N/A	Enhatls137594	enhancer	E5035	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19284	0.92632		LSM6	chr4	146175717	146191535	37055	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6230
enhrx-136917	chr5	153439360	153439361	154059800	154059801	10460	hg38	N/A	enh8810	N/A	Enhatls146314	enhancer	E5036	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1195	0.92632		MFAP3	chr5	154038958	154057450	11	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6708
enhrx-132477	chr5	62524177	62524178	63228350	63228351	10461	hg38	N/A	enh97679	N/A	Enhatls141580	enhancer	E5037	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11974	0.92668		IPO11	chr5	62403971	62628582	597697	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2268
enhrx-5894	chr1	54058478	54058479	53592805	53592806	10462	hg38	N/A	enh26707	N/A	Enhatls6426	enhancer	E5038	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083487	0.92672		GLIS1	chr1	53506236	53739164	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5893
enhrx-157673	chr8	27460974	27460975	27603457	27603458	10463	hg38	N/A	enh84927	N/A	Enhatls168438	enhancer	E5039	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1233	0.92672		CLU	chr8	27596916	27614700	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1464
enhrx-2276	chr1	19841194	19841195	19514700	19514701	10464	hg38	N/A	enh100	N/A	Enhatls2535	enhancer	E5040	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27073	0.92672		MICOS10	chr1	19484402	19629821	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2275
enhrx-123451	chr4	13264356	13264357	13262732	13262733	10465	hg38	N/A	enh97445	N/A	Enhatls132120	enhancer	E5041	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22197	0.92725		RAB28	chr4	13361353	13484365	96303	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	995
enhrx-57581	chr15	72752952	72752953	72460611	72460612	10466	hg38	N/A	enh96601	N/A	Enhatls61945	enhancer	E5042	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22317	0.92725		ARIH1	chr15	72474329	72602987	7796	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4283
enhrx-109970	chr22	32971652	32971653	32575666	32575667	10467	hg38	N/A	enh20149	N/A	Enhatls117675	enhancer	E5043	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1139	0.92731		SYN3	chr22	32507819	33058381	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1801
enhrx-1511	chr1	12536334	12536335	12476279	12476280	10468	hg38	N/A	enh11513	N/A	Enhatls1632	enhancer	E5044	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23956	0.92736		VPS13D	chr1	12230029	12512047	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1510
enhrx-94583	chr2	121495370	121495371	120737794	120737795	10469	hg38	N/A	enh76333	fant8392	Enhatls101279	enhancer	E5045	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081447	0.92736		GLI2	chr2	120735622	120992653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6509
enhrx-144986	chr6	128891998	128891999	128570853	128570854	10470	hg38	N/A	enh23588	N/A	Enhatls154937	enhancer	E5046	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10025	0.92777		PTPRK	chr6	127968784	128520616	43905	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6574
enhrx-6988	chr1	75060060	75060061	74594376	74594377	10471	hg38	N/A	N/A	N/A	Enhatls7595	enhancer	E5047	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0089946	0.92777		ERICH3	chr1	74568122	74673792	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6987
enhrx-76815	chr18	14921711	14921712	14921712	14921713	10472	hg38	N/A	enh17582	N/A	Enhatls82425	enhancer	E5048	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.068412	0.92777		ANKRD30B	chr18	14748171	14854667	57540	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	833
enhrx-102078	chr20	4573051	4573052	4592405	4592406	10473	hg38	N/A	enh34474	N/A	Enhatls109148	enhancer	E5049	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20043	0.92782		PRNP	chr20	4686349	4701590	93730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	506
enhrx-18059	chr10	11758147	11758148	11716148	11716149	10474	hg38	N/A	enh12989	N/A	Enhatls19742	enhancer	E5050	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20082	0.92811		ECHDC3	chr10	11742381	11764070	22203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	494
enhrx-134395	chr5	107266713	107266714	107931012	107931013	10475	hg38	N/A	enh71910	N/A	Enhatls143564	enhancer	E5051	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0019396	0.92811		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4186
enhrx-4695	chr1	41365360	41365361	40899688	40899689	10476	hg38	N/A	enh11779	fant1342	Enhatls5152	enhancer	E5052	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22139	0.92814		CITED4	chr1	40861053	40862363	37124	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4694
enhrx-134517	chr5	111016533	111016534	111680836	111680837	10477	hg38	N/A	enh38260	N/A	Enhatls143685	enhancer	E5053	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13346	0.92816		NREP	chr5	111669190	111997464	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4308
enhrx-63788	chr16	51272118	51272119	51238207	51238208	10478	hg38	N/A	N/A	N/A	Enhatls68469	enhancer	E5054	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22517	0.92869		SALL1	chr16	51135981	51152334	78207	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4083
enhrx-83620	chr19	34801642	34801643	34310737	34310738	10479	hg38	N/A	enh5102	N/A	Enhatls89678	enhancer	E5055	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11979	0.92923		GARRE1	chr19	34254551	34355566	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4590
enhrx-118255	chr3	123451491	123451492	123732644	123732645	10480	hg38	N/A	enh100082	N/A	Enhatls126535	enhancer	E5056	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18749	0.92932		MYLK	chr3	123610048	123884332	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6384
enhrx-18798	chr10	24907495	24907496	24618566	24618567	10481	hg38	N/A	enh27918	N/A	Enhatls20558	enhancer	E5057	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1032	0.92935		ARHGAP21	chr10	24583608	24723887	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1233
enhrx-78147	chr18	51210631	51210632	53684261	53684262	10482	hg38	N/A	N/A	N/A	Enhatls83835	enhancer	E5058	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12689	0.92935		DCC	chr18	52340196	53535899	124506	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2165
enhrx-64471	chr16	58755047	58755048	58721143	58721144	10483	hg38	N/A	N/A	N/A	Enhatls69198	enhancer	E5059	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.174	0.92935		GOT2	chr16	58707130	58734326	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4766
enhrx-102862	chr20	22204145	22204146	22223507	22223508	10484	hg38	N/A	N/A	N/A	Enhatls109985	enhancer	E5060	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094254	0.92935		FOXA2	chr20	22580997	22585455	355870	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1290
enhrx-123377	chr4	8920198	8920199	8918472	8918473	10485	hg38	N/A	N/A	N/A	Enhatls132038	enhancer	E5061	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17544	0.92946		HMX1	chr4	8846075	8871839	39203	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	921
enhrx-51264	chr14	74994557	74994558	74527854	74527855	10486	hg38	N/A	N/A	N/A	Enhatls55279	enhancer	E5062	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1067	0.92962		LTBP2	chr14	74498182	74612237	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3221
enhrx-67518	chr17	5135700	5135701	5232405	5232406	10487	hg38	N/A	N/A	N/A	Enhatls72493	enhancer	E5063	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094057	0.93024		SCIMP	chr17	5208919	5234860	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	787
enhrx-131700	chr5	40478275	40478276	40478173	40478174	10488	hg38	N/A	enh45835	N/A	Enhatls140778	enhancer	E5064	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25221	0.93024		TTC33	chr5	40512332	40755963	31732	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1491
enhrx-83609	chr19	34591273	34591274	34100368	34100369	10489	hg38	N/A	N/A	N/A	Enhatls89667	enhancer	E5065	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16875	0.93024		LSM14A	chr19	34172503	34229288	69830	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4579
enhrx-163558	chr9	19413890	19413891	19413892	19413893	10490	hg38	N/A	enh25495	N/A	Enhatls174646	enhancer	E5066	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13643	0.93024		ACER2	chr9	19409008	19452505	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	825
enhrx-132244	chr5	55937029	55937030	56641202	56641203	10491	hg38	N/A	enh22249	N/A	Enhatls141333	enhancer	E5067	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14129	0.93062		MAP3K1	chr5	56815548	56896152	171341	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2035
enhrx-127247	chr4	106013710	106013711	105092553	105092554	10492	hg38	N/A	enh63344	N/A	Enhatls136097	enhancer	E5068	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14276	0.93062		TET2	chr4	105145874	105279816	50897	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4791
enhrx-155905	chr7	153215461	153215462	153518376	153518377	10493	hg38	N/A	enh98081	N/A	Enhatls166571	enhancer	E5069	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20065	0.93063		DPP6	chr7	153748132	154894285	219663	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8717
enhrx-58981	chr15	89921898	89921899	89378667	89378668	10494	hg38	N/A	enh3783	N/A	Enhatls63512	enhancer	E5070	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12671	0.93063		POLG	chr15	89305197	89334861	43309	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5683
enhrx-143361	chr6	88183558	88183559	87473840	87473841	10495	hg38	N/A	N/A	fant23261	Enhatls153233	enhancer	E5071	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10119	0.93107		SLC35A1	chr6	87472924	87512336	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4949
enhrx-59086	chr15	90501440	90501441	89958208	89958209	10496	hg38	N/A	enh16407	N/A	Enhatls63626	enhancer	E5072	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058445	0.93156		ZNF710	chr15	90001323	90082191	39841	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5788
enhrx-14876	chr1	206713896	206713897	206540567	206540568	10497	hg38	N/A	enh87673	N/A	Enhatls16381	enhancer	E5073	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29487	0.93159		RASSF5	chr1	206507530	206589448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14875
enhrx-44214	chr12	133067991	133067992	132491405	132491406	10498	hg38	N/A	enh15113	N/A	Enhatls47734	enhancer	E5074	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038056	0.93159		FBRSL1	chr12	132489550	132585188	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9524
enhrx-73032	chr17	56479415	56479416	58402054	58402055	10499	hg38	N/A	enh4499	N/A	Enhatls78401	enhancer	E5075	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060641	0.93161		RNF43	chr17	58353675	58417582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6301
enhrx-50375	chr14	64390012	64390013	63923294	63923295	10500	hg38	N/A	enh51853	N/A	Enhatls54340	enhancer	E5076	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11777	0.93161		SYNE2	chr14	63761898	64226433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2332
enhrx-65585	chr16	74332188	74332189	74298290	74298291	10501	hg38	N/A	N/A	N/A	Enhatls70378	enhancer	E5077	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16188	0.93161		PSMD7	chr16	74296813	74306288	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5880
enhrx-119808	chr3	143958122	143958123	144239280	144239281	10502	hg38	N/A	N/A	N/A	Enhatls128185	enhancer	E5078	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24445	0.93161		DIPK2A	chr3	143971822	143992368	231646	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7937
enhrx-136171	chr5	141801056	141801057	142421491	142421492	10503	hg38	N/A	enh8742	N/A	Enhatls145472	enhancer	E5079	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.002306	0.93174		SPRY4	chr5	142310426	142325021	92320	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5962
enhrx-19091	chr10	29311669	29311670	29022740	29022741	10504	hg38	N/A	enh43259	N/A	Enhatls20864	enhancer	E5080	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13017	0.93174		LYZL1	chr10	29289060	29311232	262695	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-143837	chr6	100966658	100966659	100518782	100518783	10505	hg38	N/A	N/A	N/A	Enhatls153715	enhancer	E5081	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30828	0.93174		ASCC3	chr6	100508193	100881364	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5425
enhrx-34831	chr12	1163901	1163902	1054735	1054736	10506	hg38	N/A	enh29318	N/A	Enhatls37794	enhancer	E5082	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18191	0.93236		ERC1	chr12	990508	1495933	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	141
enhrx-14732	chr1	205512573	205512574	205543445	205543446	10507	hg38	N/A	enh12593	fant4483	Enhatls16221	enhancer	E5083	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12591	0.93236		CDK18	chr1	205504597	205532793	10550	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14731
enhrx-54359	chr15	35798652	35798653	35506451	35506452	10508	hg38	N/A	enh75622	N/A	Enhatls58543	enhancer	E5084	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16694	0.93236		DPH6	chr15	35370879	35546192	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1061
enhrx-152673	chr7	101132264	101132265	101488983	101488984	10509	hg38	N/A	enh72900	N/A	Enhatls163161	enhancer	E5085	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20722	0.93236		COL26A1	chr7	101362874	101559024	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5485
enhrx-33534	chr11	118148228	118148229	118277513	118277514	10510	hg38	N/A	enh47530	fant40061	Enhatls36390	enhancer	E5086	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24911	0.93238		MPZL2	chr11	118253415	118264536	12936	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8203
enhrx-24754	chr10	126610047	126610048	124921478	124921479	10511	hg38	N/A	enh1582	N/A	Enhatls27104	enhancer	E5087	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.37696	0.93238		ZRANB1	chr10	124942122	124988189	15557	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7189
enhrx-117628	chr3	113386308	113386309	113667461	113667462	10512	hg38	N/A	enh88762	N/A	Enhatls125895	enhancer	E5088	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047403	0.93251		USF3	chr3	113648384	113696646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5757
enhrx-12813	chr1	175490523	175490524	175521387	175521388	10513	hg38	N/A	enh89405	N/A	Enhatls14160	enhancer	E5089	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013355	0.93251		TNR	chr1	175315193	175743595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12812
enhrx-165890	chr9	92208141	92208142	89593226	89593227	10514	hg38	N/A	enh25715	N/A	Enhatls177530	enhancer	E5090	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14147	0.93251		GADD45G	chr9	89605011	89606555	7832	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3157
enhrx-23479	chr10	105554148	105554149	103794390	103794391	10515	hg38	N/A	enh13484	N/A	Enhatls25780	enhancer	E5091	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20079	0.93263		SH3PXD2A	chr10	103594026	103855584	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5914
enhrx-64786	chr16	67628836	67628837	67594933	67594934	10516	hg38	N/A	enh31886	N/A	Enhatls69541	enhancer	E5092	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26419	0.93336		CTCF	chr16	67562466	67639177	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5081
enhrx-137001	chr5	154360590	154360591	154981030	154981031	10517	hg38	N/A	N/A	N/A	Enhatls146395	enhancer	E5093	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23329	0.93336		MRPL22	chr5	154941072	154969411	5347	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6792
enhrx-165672	chr9	88108856	88108857	85493941	85493942	10518	hg38	N/A	N/A	N/A	Enhatls177300	enhancer	E5094	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12648	0.93336		AGTPBP1	chr9	85546538	85742029	35444	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2939
enhrx-16139	chr1	227133256	227133257	226945555	226945556	10519	hg38	N/A	enh43165	N/A	Enhatls17721	enhancer	E5095	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091695	0.93339		COQ8A	chr1	226940285	226987544	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16138
enhrx-157854	chr8	29877793	29877794	30020277	30020278	10520	hg38	N/A	enh10224	N/A	Enhatls168644	enhancer	E5096	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14698	0.93339		SARAF	chr8	30063002	30083208	34744	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1645
enhrx-78672	chr18	64801106	64801107	67133869	67133870	10521	hg38	N/A	enh81442	N/A	Enhatls84400	enhancer	E5097	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12842	0.93339		DSEL	chr18	67506586	67516720	368349	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2690
enhrx-20441	chr10	63872215	63872216	62112456	62112457	10522	hg38	N/A	enh1239	N/A	Enhatls22525	enhancer	E5098	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12025	0.93339		ARID5B	chr10	61901683	62096944	2490	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2876
enhrx-161913	chr8	134734125	134734126	133721882	133721883	10523	hg38	N/A	enh25357	N/A	Enhatls172951	enhancer	E5099	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.087658	0.93396		ST3GAL1	chr8	133454847	133571925	147738	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5704
enhrx-19070	chr10	28752825	28752826	28463896	28463897	10524	hg38	N/A	enh67457	N/A	Enhatls20835	enhancer	E5100	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079629	0.93396		WAC	chr10	28532492	28623112	66527	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1505
enhrx-97926	chr2	190346045	190346046	189481319	189481320	10525	hg38	N/A	enh19083	N/A	Enhatls104780	enhancer	E5101	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11902	0.93417		WDR75	chr2	189441473	189475552	3148	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-14490	chr1	203379826	203379827	203410698	203410699	10526	hg38	N/A	enh12552	N/A	Enhatls15947	enhancer	E5102	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14739	0.93417		FMOD	chr1	203340627	203351758	46560	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14489
enhrx-144414	chr6	113917329	113917330	113596127	113596128	10527	hg38	N/A	enh23537	N/A	Enhatls154343	enhancer	E5103	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14343	0.93417		MARCKS	chr6	113857344	113863475	257730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-90588	chr2	46269577	46269578	46042438	46042439	10528	hg38	N/A	enh18510	N/A	Enhatls97047	enhancer	E5104	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12393	0.93417		PRKCE	chr2	45651344	46187990	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2514
enhrx-73032	chr17	56465347	56465348	58387986	58387987	10529	hg38	N/A	enh4499	N/A	Enhatls78401	enhancer	E5105	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22671	0.93417		RNF43	chr17	58353675	58417582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6301
enhrx-136537	chr5	148862495	148862496	149482932	149482933	10530	hg38	N/A	enh22701	N/A	Enhatls145870	enhancer	E5106	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1074	0.93489		CSNK1A1	chr5	149492981	149551439	1068	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6328
enhrx-46017	chr13	48337000	48337001	47762865	47762866	10531	hg38	N/A	N/A	N/A	Enhatls49675	enhancer	E5107	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075617	0.93489		SUCLA2	chr13	47936490	48037968	124648	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1639
enhrx-128347	chr4	139517397	139517398	138596243	138596244	10532	hg38	N/A	enh8210	N/A	Enhatls137242	enhancer	E5108	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.091586	0.93489		SLC7A11	chr4	138164096	138242349	349583	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5891
enhrx-90178	chr2	38687665	38687666	38460523	38460524	10533	hg38	N/A	enh48250	N/A	Enhatls96603	enhancer	E5109	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16486	0.93521		ATL2	chr2	38293953	38377285	82238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2104
enhrx-123815	chr4	24596710	24596711	24595087	24595088	10534	hg38	N/A	enh21394	N/A	Enhatls132502	enhancer	E5110	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20204	0.93521		DHX15	chr4	24527474	24584554	8369	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-170901	chrX	13714211	13714212	13696092	13696093	10535	hg38	N/A	enh11122	N/A	Enhatls182881	enhancer	E5111	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01301	0.93521		RAB9A	chrX	13689127	13710504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	618
enhrx-136206	chr5	143123299	143123300	143743734	143743735	10536	hg38	N/A	N/A	N/A	Enhatls145521	enhancer	E5112	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23963	0.93547		HMHB1	chr5	143812160	143820716	56001	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5997
enhrx-158372	chr8	39912360	39912361	40054841	40054842	10537	hg38	N/A	enh24943	fant29374	Enhatls169205	enhancer	E5113	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11086	0.93571		IDO2	chr8	39934650	40016392	38251	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2163
enhrx-103024	chr20	25335160	25335161	25354524	25354525	10538	hg38	N/A	enh6334	N/A	Enhatls110159	enhancer	E5114	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21165	0.93571		ABHD12	chr20	25294742	25390835	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1452
enhrx-46632	chr13	73707907	73707908	73133770	73133771	10539	hg38	N/A	enh15373	N/A	Enhatls50348	enhancer	E5115	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26774	0.93603		KLF5	chr13	73054975	73077541	52308	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2254
enhrx-100483	chr2	231356935	231356936	230492220	230492221	10540	hg38	N/A	enh82131	N/A	Enhatls107492	enhancer	E5116	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10904	0.93603		SP100	chr2	230415941	230545606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12409
enhrx-68273	chr17	9877163	9877164	9973846	9973847	10541	hg38	N/A	enh4245	N/A	Enhatls73276	enhancer	E5117	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17597	0.93603		GAS7	chr17	9910605	10198606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1542
enhrx-119786	chr3	143025479	143025480	143306637	143306638	10542	hg38	N/A	enh63213	N/A	Enhatls128163	enhancer	E5118	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042912	0.93615		SLC9A9	chr3	143265221	143848468	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7915
enhrx-33445	chr11	117360996	117360997	117490281	117490282	10543	hg38	N/A	N/A	N/A	Enhatls36299	enhancer	E5119	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.00069241	0.93624		DSCAML1	chr11	117427771	117817525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8114
enhrx-106326	chr21	17552235	17552236	16179915	16179916	10544	hg38	N/A	enh34783	N/A	Enhatls113680	enhancer	E5120	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0071076	0.93624		USP25	chr21	15729981	15880064	297742	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	209
enhrx-117755	chr3	116669301	116669302	116950454	116950455	10545	hg38	N/A	N/A	N/A	Enhatls126028	enhancer	E5121	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22157	0.93652		LSAMP	chr3	115802373	117139389	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5884
enhrx-175158	chrX	103580664	103580665	104335983	104335984	10546	hg38	N/A	enh42708	N/A	Enhatls187336	enhancer	E5122	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14507	0.93652		ESX1	chrX	104250037	104254933	72892	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4875
enhrx-23774	chr10	112617447	112617448	110857689	110857690	10547	hg38	N/A	enh1503	N/A	Enhatls26096	enhancer	E5123	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04661	0.93652		PDCD4	chr10	110871794	110900006	14035	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6209
enhrx-2883	chr1	24924327	24924328	24597836	24597837	10548	hg38	N/A	enh11622	N/A	Enhatls3213	enhancer	E5124	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11593	0.93684		NCMAP	chr1	24556086	24609328	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2882
enhrx-17809	chr10	5596452	5596453	5554489	5554490	10549	hg38	N/A	enh12943	fant34539	Enhatls19455	enhancer	E5125	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089238	0.93753		CALML3	chr10	5524960	5526771	27546	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	244
enhrx-146852	chr6	166060670	166060671	165647182	165647183	10550	hg38	N/A	enh66320	N/A	Enhatls156980	enhancer	E5126	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17847	0.93767		PDE10A	chr6	165327288	165987965	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8440
enhrx-132066	chr5	53592335	53592336	54296505	54296506	10551	hg38	N/A	enh61262	N/A	Enhatls141148	enhancer	E5127	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074885	0.93767		ARL15	chr5	53883941	54310582	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1857
enhrx-108527	chr22	19815293	19815294	19827770	19827771	10552	hg38	N/A	enh20061	N/A	Enhatls116059	enhancer	E5128	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28931	0.93767		GNB1L	chr22	19783222	19854939	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	358
enhrx-154455	chr7	134040698	134040699	134355946	134355947	10553	hg38	N/A	enh24525	N/A	Enhatls165059	enhancer	E5129	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25199	0.93777		SLC35B4	chr7	134289331	134316930	35984	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7267
enhrx-106298	chr21	16665700	16665701	15293381	15293382	10554	hg38	N/A	enh19828	N/A	Enhatls113652	enhancer	E5130	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12901	0.93777		NRIP1	chr21	14961234	15065815	225126	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-68573	chr17	13951096	13951097	14047779	14047780	10555	hg38	N/A	N/A	N/A	Enhatls73589	enhancer	E5131	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14243	0.93786		COX10	chr17	14069495	14208677	18168	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1842
enhrx-65578	chr16	73205545	73205546	73171646	73171647	10556	hg38	N/A	enh16775	N/A	Enhatls70370	enhancer	E5132	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017458	0.93786		ZFHX3	chr16	72782884	73891871	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5873
enhrx-143892	chr6	104862778	104862779	104414903	104414904	10557	hg38	N/A	N/A	N/A	Enhatls153772	enhancer	E5133	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13334	0.93861		HACE1	chr6	104728093	104859919	309124	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5480
enhrx-40476	chr12	79818106	79818107	79424326	79424327	10558	hg38	N/A	enh14845	fant42408	Enhatls43751	enhancer	E5134	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055847	0.93861		SYT1	chr12	78863992	79452008	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5786
enhrx-24095	chr10	117424415	117424416	115664905	115664906	10559	hg38	N/A	enh96146	N/A	Enhatls26450	enhancer	E5135	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.033916	0.93861		ATRNL1	chr10	115093364	115948999	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6530
enhrx-15843	chr1	223907349	223907350	223719647	223719648	10560	hg38	N/A	enh12712	fant4978	Enhatls17392	enhancer	E5136	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2124	0.93861		CAPN2	chr1	223701592	223776018	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15842
enhrx-24428	chr10	123005561	123005562	121246047	121246048	10561	hg38	N/A	enh13574	N/A	Enhatls26799	enhancer	E5137	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1129	0.93861		FGFR2	chr10	121478331	121598458	230251	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6863
enhrx-109992	chr22	33936433	33936434	33540447	33540448	10562	hg38	N/A	enh53936	N/A	Enhatls117698	enhancer	E5138	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.36093	0.93861		LARGE1	chr22	33162225	33922841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1823
enhrx-84423	chr19	39149438	39149439	38658798	38658799	10563	hg38	N/A	enh5125	fant56941	Enhatls90486	enhancer	E5139	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21751	0.93877		ACTN4	chr19	38647648	38731589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5393
enhrx-157891	chr8	30534285	30534286	30676768	30676769	10564	hg38	N/A	N/A	N/A	Enhatls168689	enhancer	E5140	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20121	0.93887		GSR	chr8	30678065	30727846	13	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1682
enhrx-63895	chr16	53766570	53766571	53732658	53732659	10565	hg38	N/A	enh4023	N/A	Enhatls68577	enhancer	E5141	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29569	0.93887		FTO	chr16	53701691	54153448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4190
enhrx-1513	chr1	12588495	12588496	12528453	12528454	10566	hg38	N/A	enh11514	N/A	Enhatls1635	enhancer	E5142	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050259	0.93894		VPS13D	chr1	12230029	12512047	11397	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1512
enhrx-15888	chr1	224470426	224470427	224282724	224282725	10567	hg38	N/A	N/A	N/A	Enhatls17447	enhancer	E5143	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16578	0.93904		NVL	chr1	224227333	224330189	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15887
enhrx-88719	chr2	16129926	16129927	15989804	15989805	10568	hg38	N/A	enh18294	N/A	Enhatls95051	enhancer	E5144	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.044993	0.93904		MYCN	chr2	15940549	15947007	39261	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	645
enhrx-6239	chr1	59892374	59892375	59426702	59426703	10569	hg38	N/A	enh11922	N/A	Enhatls6793	enhancer	E5145	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051518	0.93904		FGGY	chr1	59296637	59762730	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6238
enhrx-135211	chr5	130137835	130137836	130802142	130802143	10570	hg38	N/A	N/A	N/A	Enhatls144435	enhancer	E5146	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14068	0.93904		HINT1	chr5	131155382	131165341	351831	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5002
enhrx-165467	chr9	80466927	80466928	77852011	77852012	10571	hg38	N/A	enh25618	N/A	Enhatls177076	enhancer	E5147	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096201	0.93904		GNAQ	chr9	77716096	78031811	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2734
enhrx-20470	chr10	64524539	64524540	62764779	62764780	10572	hg38	N/A	enh13257	N/A	Enhatls22557	enhancer	E5148	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.00069576	0.93904		ADO	chr10	62804719	62808479	32844	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2905
enhrx-85055	chr19	42278617	42278618	41774712	41774713	10573	hg38	N/A	enh48194	N/A	Enhatls91180	enhancer	E5149	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.070979	0.93942		CEACAM6	chr19	41750976	41772211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6025
enhrx-126913	chr4	99693263	99693264	98772112	98772113	10574	hg38	N/A	N/A	N/A	Enhatls135750	enhancer	E5150	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049014	0.93943		TSPAN5	chr4	98470366	98658611	94154	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4457
enhrx-6024	chr1	55187597	55187598	54721924	54721925	10575	hg38	N/A	N/A	N/A	Enhatls6567	enhancer	E5151	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16957	0.93956		TTC4	chr1	54715860	54742657	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6023
enhrx-40931	chr12	93529223	93529224	93135447	93135448	10576	hg38	N/A	enh29864	N/A	Enhatls44235	enhancer	E5152	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21551	0.93956		EEA1	chr12	92770636	92929295	203695	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6241
enhrx-128678	chr4	146760545	146760546	145839393	145839394	10577	hg38	N/A	enh37157	N/A	Enhatls137580	enhancer	E5153	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28751	0.93956		ZNF827	chr4	145757626	145938823	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6222
enhrx-51334	chr14	75412559	75412560	74945856	74945857	10578	hg38	N/A	enh15774	N/A	Enhatls55354	enhancer	E5154	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23845	0.93958		PGF	chr14	74941833	74955626	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3291
enhrx-112833	chr3	15675775	15675776	15634268	15634269	10579	hg38	N/A	enh63109	fant11328	Enhatls120732	enhancer	E5155	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10439	0.93958		BTD	chr3	15601340	15722311	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	962
enhrx-5952	chr1	54603212	54603213	54137539	54137540	10580	hg38	N/A	N/A	N/A	Enhatls6488	enhancer	E5156	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0042288	0.93958		CDCP2	chr1	54132686	54153770	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5951
enhrx-124346	chr4	41543882	41543883	41541865	41541866	10581	hg38	N/A	enh21493	N/A	Enhatls133069	enhancer	E5157	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24665	0.94006		LIMCH1	chr4	41359606	41700044	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1890
enhrx-111172	chr22	43962087	43962088	43566207	43566208	10582	hg38	N/A	enh97223	N/A	Enhatls118962	enhancer	E5158	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.039297	0.9403		EFCAB6	chr22	43528743	43812305	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3003
enhrx-60132	chr16	1696132	1696133	1646131	1646132	10583	hg38	N/A	N/A	N/A	Enhatls64679	enhancer	E5159	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15144	0.94063		CRAMP1	chr16	1612336	1677908	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	427
enhrx-42208	chr12	110309905	110309906	109872100	109872101	10584	hg38	N/A	enh14985	N/A	Enhatls45597	enhancer	E5160	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082859	0.94083		GLTP	chr12	109850944	109880541	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7518
enhrx-109476	chr22	29913788	29913789	29517799	29517800	10585	hg38	N/A	enh6814	N/A	Enhatls117154	enhancer	E5161	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0086327	0.94098		THOC5	chr22	29505878	29555216	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1307
enhrx-147960	chr7	7736626	7736627	7696995	7696996	10586	hg38	N/A	enh39861	N/A	Enhatls158117	enhancer	E5162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12049	0.94109		RPA3	chr7	7636517	7718607	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	772
enhrx-147960	chr7	7736626	7736627	7696995	7696996	10587	hg38	N/A	enh39861	N/A	Enhatls158117	enhancer	E5162	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12049	0.94109		UMAD1	chr7	7640751	7968020	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	772
enhrx-139309	chr6	24690964	24690965	24690736	24690737	10588	hg38	N/A	N/A	N/A	Enhatls148938	enhancer	E5163	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17635	0.94114		ACOT13	chr6	24667034	24705065	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	897
enhrx-85057	chr19	42303511	42303512	41799579	41799580	10589	hg38	N/A	N/A	N/A	Enhatls91182	enhancer	E5164	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038747	0.94114		CEACAM3	chr19	41796586	41811554	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6027
enhrx-170763	chrX	10069441	10069442	10101401	10101402	10590	hg38	N/A	enh26150	N/A	Enhatls182728	enhancer	E5165	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15552	0.94114		WWC3	chrX	10015253	10144474	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	480
enhrx-60721	chr16	4117846	4117847	4067845	4067846	10591	hg38	N/A	enh96655	N/A	Enhatls65290	enhancer	E5166	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22095	0.94157		ADCY9	chr16	3953386	4116442	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1016
enhrx-956	chr1	8319856	8319857	8259796	8259797	10592	hg38	N/A	enh11468	N/A	Enhatls1017	enhancer	E5167	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099799	0.94157		SLC45A1	chr1	8318113	8344167	39359	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-147140	chr6	170340661	170340662	170025437	170025438	10593	hg38	N/A	enh56126	N/A	Enhatls157255	enhancer	E5168	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.099208	0.94165		ERMARD	chr6	169751621	169781600	241422	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8728
enhrx-129556	chr4	170055224	170055225	169134073	169134074	10594	hg38	N/A	enh21936	N/A	Enhatls138496	enhancer	E5169	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03615	0.94199		SH3RF1	chr4	169094258	169270956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7100
enhrx-112068	chr3	5230791	5230792	5189106	5189107	10595	hg38	N/A	N/A	N/A	Enhatls119921	enhancer	E5170	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13093	0.94199		EDEM1	chr3	5187706	5219958	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	197
enhrx-21879	chr10	89879082	89879083	88119325	88119326	10596	hg38	N/A	enh1406	N/A	Enhatls24087	enhancer	E5171	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050565	0.94204		PTEN	chr10	87862637	87971930	144836	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4314
enhrx-136548	chr5	148942428	148942429	149562865	149562866	10597	hg38	N/A	enh8790	N/A	Enhatls145881	enhancer	E5172	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10448	0.94228		ARHGEF37	chr5	149551946	149634968	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6339
enhrx-100985	chr2	238200294	238200295	237291651	237291652	10598	hg38	N/A	enh19390	fant10759	Enhatls108022	enhancer	E5173	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13127	0.94232		COL6A3	chr2	237324017	237414207	32325	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12911
enhrx-131148	chr5	32193862	32193863	32193756	32193757	10599	hg38	N/A	enh63393	N/A	Enhatls140178	enhancer	E5174	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18428	0.94236		GOLPH3	chr5	32124715	32174319	17304	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	939
enhrx-116515	chr3	73768067	73768068	73718916	73718917	10600	hg38	N/A	enh35551	N/A	Enhatls124695	enhancer	E5175	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.019053	0.94259		PDZRN3	chr3	73382430	73624941	89580	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4644
enhrx-31696	chr11	78324367	78324368	78613322	78613323	10601	hg38	N/A	enh92316	N/A	Enhatls34445	enhancer	E5176	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18671	0.94272		NARS2	chr11	78435967	78574874	36507	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6365
enhrx-54379	chr15	37136809	37136810	36844608	36844609	10602	hg38	N/A	N/A	N/A	Enhatls58567	enhancer	E5177	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12544	0.94293		MEIS2	chr15	36889203	37101299	24765	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1081
enhrx-176773	chrX	140350836	140350837	141256707	141256708	10603	hg38	N/A	N/A	N/A	Enhatls189012	enhancer	E5178	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079207	0.94361		SPANXC	chrX	141241462	141242517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6490
enhrx-160442	chr8	98866251	98866252	97854023	97854024	10604	hg38	N/A	enh63801	N/A	Enhatls171377	enhancer	E5179	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029516	0.9437		LAPTM4B	chr8	97775056	97853013	85	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4233
enhrx-145939	chr6	148768051	148768052	148446915	148446916	10605	hg38	N/A	enh23760	N/A	Enhatls155991	enhancer	E5180	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28673	0.94376		SASH1	chr6	148342837	148552044	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7527
enhrx-143822	chr6	100623965	100623966	100176089	100176090	10606	hg38	N/A	enh39277	N/A	Enhatls153700	enhancer	E5181	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15272	0.94376		MCHR2	chr6	99918518	99994247	175780	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5410
enhrx-107457	chr21	43269187	43269188	41849078	41849079	10607	hg38	N/A	N/A	N/A	Enhatls114899	enhancer	E5182	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2472	0.94376		PRDM15	chr21	41798224	41879482	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1340
enhrx-106975	chr21	35459476	35459477	34087177	34087178	10608	hg38	N/A	enh6631	N/A	Enhatls114373	enhancer	E5183	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19434	0.94376		MRPS6	chr21	34073577	34143030	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	858
enhrx-106975	chr21	35459476	35459477	34087177	34087178	10609	hg38	N/A	enh6631	N/A	Enhatls114373	enhancer	E5183	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19434	0.94376		SLC5A3	chr21	34073577	34106260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	858
enhrx-130467	chr5	2733139	2733140	2733025	2733026	10610	hg38	N/A	N/A	N/A	Enhatls139471	enhancer	E5184	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.026605	0.94376		IRX2	chr5	2745844	2751677	5614	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	258
enhrx-163210	chr9	9153977	9153978	9153977	9153978	10611	hg38	N/A	N/A	N/A	Enhatls174284	enhancer	E5185	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065424	0.94376		PTPRD	chr9	8314245	10613002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	477
enhrx-20522	chr10	68047752	68047753	66287994	66287995	10612	hg38	N/A	N/A	N/A	Enhatls22612	enhancer	E5186	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21439	0.94376		CTNNA3	chr10	65912456	67763637	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2957
enhrx-45807	chr13	44119823	44119824	43545687	43545688	10613	hg38	N/A	enh64710	N/A	Enhatls49435	enhancer	E5187	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15208	0.94376		ENOX1	chr13	43213129	43786972	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1429
enhrx-157743	chr8	28004951	28004952	28147434	28147435	10614	hg38	N/A	N/A	fant29097	Enhatls168512	enhancer	E5188	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094665	0.94376		ELP3	chr8	28089672	28191156	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1534
enhrx-26921	chr11	17026505	17026506	17004958	17004959	10615	hg38	N/A	enh13817	N/A	Enhatls29351	enhancer	E5189	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15568	0.94376		PLEKHA7	chr11	16777296	17014415	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-68204	chr17	9054642	9054643	9151325	9151326	10616	hg38	N/A	enh52413	N/A	Enhatls73203	enhancer	E5190	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23305	0.94376		NTN1	chr17	9021509	9244000	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1473
enhrx-171960	chrX	39351807	39351808	39492553	39492554	10617	hg38	N/A	enh49586	N/A	Enhatls184001	enhancer	E5191	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048771	0.94376		BCOR	chrX	40049814	40177329	554698	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1677
enhrx-171463	chrX	23522514	23522515	23504397	23504398	10618	hg38	N/A	enh26195	N/A	Enhatls183489	enhancer	E5192	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08852	0.94405		PTCHD1	chrX	23334848	23404374	94755	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1180
enhrx-78994	chr18	77694814	77694815	79934814	79934815	10619	hg38	N/A	N/A	N/A	Enhatls84744	enhancer	E5193	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053038	0.94424		SLC66A2	chr18	79902419	79951653	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3012
enhrx-171573	chrX	24888459	24888460	24870342	24870343	10620	hg38	N/A	enh93868	N/A	Enhatls183603	enhancer	E5194	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12234	0.94432		POLA1	chrX	24693917	24996986	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1290
enhrx-147916	chr7	7435612	7435613	7395981	7395982	10621	hg38	N/A	enh102051	N/A	Enhatls158072	enhancer	E5195	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0096072	0.94443		COL28A1	chr7	7356567	7535873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	728
enhrx-117137	chr3	104318249	104318250	104599405	104599406	10622	hg38	N/A	enh82680	N/A	Enhatls125355	enhancer	E5196	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022806	0.94443		ALCAM	chr3	105366908	105576900	765458	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5266
enhrx-77123	chr18	21801251	21801252	24221287	24221288	10623	hg38	N/A	enh32510	N/A	Enhatls82770	enhancer	E5197	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11924	0.94443		OSBPL1A	chr18	24162044	24397824	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1141
enhrx-83422	chr19	32614481	32614482	32123575	32123576	10624	hg38	N/A	N/A	N/A	Enhatls89473	enhancer	E5198	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21685	0.94443		ZNF507	chr19	32345593	32387667	218335	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4392
enhrx-99353	chr2	212700579	212700580	211835854	211835855	10625	hg38	N/A	enh97054	N/A	Enhatls106288	enhancer	E5199	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049447	0.94485		ERBB4	chr2	211375716	212538841	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11279
enhrx-45312	chr13	34567401	34567402	33993264	33993265	10626	hg38	N/A	enh60447	N/A	Enhatls48912	enhancer	E5200	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021061	0.94494		RFC3	chr13	33818068	33966558	23093	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	934
enhrx-93389	chr2	100305359	100305360	99688897	99688898	10627	hg38	N/A	N/A	N/A	Enhatls100018	enhancer	E5201	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17166	0.94506		AFF3	chr2	99545418	100142590	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5315
enhrx-129533	chr4	169601115	169601116	168679964	168679965	10628	hg38	N/A	enh83452	N/A	Enhatls138463	enhancer	E5202	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15183	0.94506		PALLD	chr4	168497051	168928457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7077
enhrx-30645	chr11	67909612	67909613	68142145	68142146	10629	hg38	N/A	enh50865	N/A	Enhatls33316	enhancer	E5203	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17217	0.94511		KMT5B	chr11	68154862	68213828	2475	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5314
enhrx-49484	chr14	50188669	50188670	49721951	49721952	10630	hg38	N/A	N/A	N/A	Enhatls53384	enhancer	E5204	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16007	0.94511		KLHDC1	chr14	49693119	49753150	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1441
enhrx-102490	chr20	14801993	14801994	14821347	14821348	10631	hg38	N/A	enh82210	N/A	Enhatls109587	enhancer	E5205	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23617	0.94511		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	918
enhrx-90408	chr2	43696438	43696439	43469299	43469300	10632	hg38	N/A	enh5458	N/A	Enhatls96857	enhancer	E5206	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19577	0.94541		THADA	chr2	43230850	43596038	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2334
enhrx-175727	chrX	117103476	117103477	117969513	117969514	10633	hg38	N/A	enh98374	N/A	Enhatls187922	enhancer	E5207	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.061658	0.94541		KLHL13	chrX	117897812	118117340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5444
enhrx-170875	chrX	13007088	13007089	12988969	12988970	10634	hg38	N/A	enh42402	N/A	Enhatls182848	enhancer	E5208	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.05256	0.94589		TMSB4X	chrX	12975109	12977227	9430	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	592
enhrx-156238	chr8	637342	637343	687342	687343	10635	hg38	N/A	enh100762	N/A	Enhatls166901	enhancer	E5209	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053762	0.94589		ERICH1	chr8	614745	731224	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	29
enhrx-4427	chr1	39462959	39462960	38997287	38997288	10636	hg38	N/A	N/A	N/A	Enhatls4872	enhancer	E5210	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19239	0.94604		AKIRIN1	chr1	38991275	39006059	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4426
enhrx-79046	chr19	290320	290321	290320	290321	10637	hg38	N/A	N/A	fant55702	Enhatls84796	enhancer	E5211	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15149	0.94604		PLPP2	chr19	281039	291403	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16
enhrx-50828	chr14	69802350	69802351	69335633	69335634	10638	hg38	N/A	N/A	N/A	Enhatls54820	enhancer	E5212	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.45479	0.94604		GALNT16	chr14	69259963	69357033	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2785
enhrx-77726	chr18	42939546	42939547	45359581	45359582	10639	hg38	N/A	enh52728	N/A	Enhatls83397	enhancer	E5213	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16565	0.94604		SLC14A2	chr18	45212994	45683688	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1744
enhrx-135612	chr5	135193827	135193828	135858138	135858139	10640	hg38	N/A	enh97769	N/A	Enhatls144880	enhancer	E5214	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12363	0.94613		SLC25A48	chr5	135579201	135889770	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5403
enhrx-161220	chr8	120238793	120238794	119226553	119226554	10641	hg38	N/A	enh85221	N/A	Enhatls172189	enhancer	E5215	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14269	0.94613		MAL2	chr8	119165033	119245673	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5011
enhrx-117895	chr3	119879041	119879042	120160194	120160195	10642	hg38	N/A	enh7479	N/A	Enhatls126167	enhancer	E5216	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094682	0.94641		GPR156	chr3	120165477	120285222	886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6024
enhrx-lit81	chr12	109423779	109423780	108985974	108985975	10643	hg38					enhancer	E5217	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25487	0.94641							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-57408	chr15	70419860	70419861	70127521	70127522	10644	hg38	N/A	enh52073	N/A	Enhatls61772	enhancer	E5218	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0085007	0.94641		TLE3	chr15	70047789	70098176	27311	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4110
enhrx-30265	chr11	66077500	66077501	66310029	66310030	10645	hg38	N/A	enh1835	N/A	Enhatls32895	enhancer	E5219	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.022528	0.94641		CD248	chr11	66314493	66317044	1249	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4934
enhrx-21995	chr10	91236689	91236690	89476932	89476933	10646	hg38	N/A	enh13382	N/A	Enhatls24202	enhancer	E5220	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14799	0.94641		SLC16A12	chr10	89430298	89556641	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4430
enhrx-20788	chr10	71120672	71120673	69360916	69360917	10647	hg38	N/A	enh28194	N/A	Enhatls22888	enhancer	E5221	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16425	0.94641		HK1	chr10	69269983	69401884	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3223
enhrx-77948	chr18	46142573	46142574	48616202	48616203	10648	hg38	N/A	enh88340	N/A	Enhatls83622	enhancer	E5222	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.014692	0.94641		CTIF	chr18	48539030	48863217	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1966
enhrx-88296	chr2	7889384	7889385	7749253	7749254	10649	hg38	N/A	enh58864	N/A	Enhatls94564	enhancer	E5223	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.02048	0.94641		RNF144A	chr2	6917411	7068286	680668	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	222
enhrx-42805	chr12	116310885	116310886	115873080	115873081	10650	hg38	N/A	enh15022	N/A	Enhatls46225	enhancer	E5224	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080904	0.94641		MED13L	chr12	115958575	116277693	81126	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8115
enhrx-134395	chr5	107272486	107272487	107936785	107936786	10651	hg38	N/A	enh71910	N/A	Enhatls143564	enhancer	E5225	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20701	0.94641		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4186
enhrx-104331	chr20	41106295	41106296	42477655	42477656	10652	hg38	N/A	N/A	N/A	Enhatls111580	enhancer	E5226	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10514	0.94641		PTPRT	chr20	42072751	43189970	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2759
enhrx-141701	chr6	45503827	45503828	45536090	45536091	10653	hg38	N/A	enh66212	N/A	Enhatls151499	enhancer	E5227	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21218	0.94641		RUNX2	chr6	45328316	45664349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3289
enhrx-74213	chr17	68267881	68267882	70271740	70271741	10654	hg38	N/A	N/A	N/A	Enhatls79660	enhancer	E5228	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075868	0.94665		KCNJ2	chr17	70168672	70180044	86680	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7482
enhrx-151131	chr7	79163913	79163914	79534597	79534598	10655	hg38	N/A	N/A	N/A	Enhatls161566	enhancer	E5229	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10088	0.94666		MAGI2	chr7	78017054	79453667	73816	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3943
enhrx-137427	chr5	168527884	168527885	169100879	169100880	10656	hg38	N/A	enh38643	N/A	Enhatls146863	enhancer	E5230	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13389	0.94666		SLIT3	chr5	168661739	169301139	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7218
enhrx-94464	chr2	119639234	119639235	118881658	118881659	10657	hg38	N/A	enh104730	N/A	Enhatls101151	enhancer	E5231	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.078836	0.94672		EN1	chr2	118842170	118847648	29042	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6390
enhrx-40938	chr12	93833929	93833930	93440153	93440154	10658	hg38	N/A	N/A	N/A	Enhatls44248	enhancer	E5232	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14659	0.94672		UBE2N	chr12	93405683	93441947	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6248
enhrx-133920	chr5	91237495	91237496	91941678	91941679	10659	hg38	N/A	enh77676	N/A	Enhatls143070	enhancer	E5233	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097406	0.94673		ARRDC3	chr5	91368630	91383317	553152	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3711
enhrx-78505	chr18	60178214	60178215	62510981	62510982	10660	hg38	N/A	enh4886	N/A	Enhatls84225	enhancer	E5234	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.074215	0.94673		ZCCHC2	chr18	62523024	62578579	10003	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2523
enhrx-148451	chr7	22429373	22429374	22389754	22389755	10661	hg38	N/A	enh9644	N/A	Enhatls158643	enhancer	E5235	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.064369	0.94673		RAPGEF5	chr7	22118235	22357154	13733	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1263
enhrx-109536	chr22	30217401	30217402	29821412	29821413	10662	hg38	N/A	N/A	N/A	Enhatls117213	enhancer	E5236	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.048551	0.94694		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1367
enhrx-115185	chr3	50662281	50662282	50624850	50624851	10663	hg38	N/A	enh20596	N/A	Enhatls123230	enhancer	E5237	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29414	0.94695		MAPKAPK3	chr3	50611907	50649291	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3314
enhrx-51426	chr14	76278399	76278400	75812056	75812057	10664	hg38	N/A	enh3331	N/A	Enhatls55462	enhancer	E5238	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16945	0.94695		TTLL5	chr14	75661223	75955079	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3383
enhrx-101603	chr20	371049	371050	390405	390406	10665	hg38	N/A	N/A	N/A	Enhatls108668	enhancer	E5239	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1058	0.94782		TRIB3	chr20	362834	397559	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	31
enhrx-106330	chr21	17936262	17936263	16563942	16563943	10666	hg38	N/A	enh19841	N/A	Enhatls113686	enhancer	E5240	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028331	0.9481		USP25	chr21	15729981	15880064	680262	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	213
enhrx-38860	chr12	54219240	54219241	53825456	53825457	10667	hg38	N/A	enh43743	N/A	Enhatls42043	enhancer	E5241	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098182	0.94811		CALCOCO1	chr12	53708516	53727745	90854	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-57386	chr15	69896461	69896462	69604122	69604123	10668	hg38	N/A	enh44146	N/A	Enhatls61747	enhancer	E5242	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.098295	0.94821		RPLP1	chr15	69452813	69456205	145322	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4088
enhrx-63916	chr16	55498005	55498006	55464093	55464094	10669	hg38	N/A	N/A	N/A	Enhatls68601	enhancer	E5243	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054896	0.94821		MMP2	chr16	55389699	55506691	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4211
enhrx-33016	chr11	111234167	111234168	111363442	111363443	10670	hg38	N/A	enh1999	N/A	Enhatls35826	enhancer	E5244	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14504	0.94821		POU2AF1	chr11	111352254	111449981	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7685
enhrx-135083	chr5	127389476	127389477	128053784	128053785	10671	hg38	N/A	enh83964	N/A	Enhatls144303	enhancer	E5245	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14654	0.9483		SLC12A2	chr5	128083765	128189677	27983	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4874
enhrx-6809	chr1	68991735	68991736	68526052	68526053	10672	hg38	N/A	enh79057	N/A	Enhatls7413	enhancer	E5246	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13473	0.9483		DEPDC1	chr1	68474151	68497221	26702	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6808
enhrx-137002	chr5	154448403	154448404	155068843	155068844	10673	hg38	N/A	enh97781	N/A	Enhatls146396	enhancer	E5247	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079409	0.9483		KIF4B	chr5	155013754	155018141	48645	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6793
enhrx-84688	chr19	40350834	40350835	39860194	39860195	10674	hg38	N/A	N/A	N/A	Enhatls90786	enhancer	E5248	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0099848	0.94844		FCGBP	chr19	39863322	39934626	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5658
enhrx-148935	chr7	32133239	32133240	32093627	32093628	10675	hg38	N/A	enh40027	fant26067	Enhatls159178	enhancer	E5249	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21276	0.94844		PDE1C	chr7	31751178	32428131	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1747
enhrx-24438	chr10	123271700	123271701	121512186	121512187	10676	hg38	N/A	enh28514	N/A	Enhatls26809	enhancer	E5250	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32836	0.94873		FGFR2	chr10	121478331	121598458	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6873
enhrx-24179	chr10	118448066	118448067	116688555	116688556	10677	hg38	N/A	enh64386	N/A	Enhatls26534	enhancer	E5251	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33099	0.94873		HSPA12A	chr10	116671191	116850251	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6614
enhrx-144130	chr6	109670917	109670918	109349714	109349715	10678	hg38	N/A	enh23490	N/A	Enhatls154036	enhancer	E5252	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21354	0.94873		CD164	chr6	109366513	109382467	14947	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5718
enhrx-32310	chr11	94571304	94571305	94838138	94838139	10679	hg38	N/A	enh79989	N/A	Enhatls35084	enhancer	E5253	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086093	0.94876		AMOTL1	chr11	94706430	94876748	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6979
enhrx-153999	chr7	128075520	128075521	128435466	128435467	10680	hg38	N/A	enh24494	N/A	Enhatls164568	enhancer	E5254	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17205	0.9489		IMPDH1	chr7	128392276	128409986	7886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6811
enhrx-136939	chr5	154080893	154080894	154701333	154701334	10681	hg38	N/A	enh22747	N/A	Enhatls146334	enhancer	E5255	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13901	0.94906		LARP1	chr5	154682985	154817605	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6730
enhrx-81230	chr19	10302226	10302227	10191550	10191551	10682	hg38	N/A	enh4999	N/A	Enhatls87101	enhancer	E5256	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31486	0.94907		DNMT1	chr19	10133345	10231286	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2200
enhrx-114549	chr3	47515123	47515124	47473633	47473634	10683	hg38	N/A	N/A	N/A	Enhatls122583	enhancer	E5257	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18853	0.94935		SCAP	chr3	47413680	47477126	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2678
enhrx-156714	chr8	11604379	11604380	11746870	11746871	10684	hg38	hs508	enh10169	N/A	Enhatls167414	enhancer	E5258	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.043216	0.94948		GATA4	chr8	11676958	11760002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-107508	chr21	43683476	43683477	42263366	42263367	10685	hg38	N/A	enh20005	N/A	Enhatls114954	enhancer	E5259	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18954	0.94958		ABCG1	chr21	42199688	42297244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1391
enhrx-125939	chr4	77101139	77101140	76179986	76179987	10686	hg38	N/A	N/A	N/A	Enhatls134733	enhancer	E5260	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.025362	0.94967		SCARB2	chr4	76158736	76234536	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3483
enhrx-19091	chr10	29537373	29537374	29248444	29248445	10687	hg38	N/A	enh115409	N/A	Enhatls20864	enhancer	E5261	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0099324	0.94967		LYZL1	chr10	29289060	29311232	39973	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1526
enhrx-134174	chr5	96294929	96294930	96959225	96959226	10688	hg38	N/A	enh8576	N/A	Enhatls143339	enhancer	E5262	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12076	0.94967		LNPEP	chr5	96936079	97037513	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3965
enhrx-135665	chr5	136104389	136104390	136768700	136768701	10689	hg38	N/A	enh8713	N/A	Enhatls144936	enhancer	E5263	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13926	0.94967		SPOCK1	chr5	136975297	137499326	206102	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5456
enhrx-134385	chr5	106345641	106345642	107009940	107009941	10690	hg38	N/A	N/A	N/A	Enhatls143555	enhancer	E5264	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.029359	0.94967		EFNA5	chr5	107376893	107670937	366387	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4176
enhrx-56568	chr15	61975509	61975510	61683310	61683311	10691	hg38	N/A	enh68950	N/A	Enhatls60863	enhancer	E5265	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11504	0.94967		VPS13C	chr15	61852388	62060473	168501	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3270
enhrx-51489	chr14	77375889	77375890	76909546	76909547	10692	hg38	N/A	enh3334	N/A	Enhatls55531	enhancer	E5266	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24333	0.94975		LRRC74A	chr14	76826371	76870304	28590	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3446
enhrx-51881	chr14	89361644	89361645	88895300	88895301	10693	hg38	N/A	enh80909	N/A	Enhatls55943	enhancer	E5267	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25744	0.94975		TTC8	chr14	88824623	88881078	12104	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3838
enhrx-128404	chr4	140872432	140872433	139951278	139951279	10694	hg38	N/A	enh8228	N/A	Enhatls137303	enhancer	E5268	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1405	0.94975		MAML3	chr4	139716752	140154184	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5948
enhrx-151278	chr7	83334079	83334080	83704763	83704764	10695	hg38	N/A	enh109130	N/A	Enhatls161728	enhancer	E5269	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14385	0.94975		SEMA3E	chr7	83363237	83649139	53531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4090
enhrx-100071	chr2	224484477	224484478	223619760	223619761	10696	hg38	N/A	enh76583	N/A	Enhatls107064	enhancer	E5270	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0051694	0.94981		SCG2	chr2	223596939	223602361	13848	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11997
enhrx-145938	chr6	148666608	148666609	148345472	148345473	10697	hg38	N/A	enh23755	N/A	Enhatls155988	enhancer	E5271	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027923	0.94981		SASH1	chr6	148342837	148552044	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7526
enhrx-17668	chr10	1338481	1338482	1296286	1296287	10698	hg38	N/A	enh47327	N/A	Enhatls19305	enhancer	E5272	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.36758	0.95014		ADARB2	chr10	1177312	1737525	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	103
enhrx-99397	chr2	215595796	215595797	214731072	214731073	10699	hg38	N/A	N/A	N/A	Enhatls106335	enhancer	E5273	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20309	0.9502		BARD1	chr2	214725645	214809683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11323
enhrx-142068	chr6	52482112	52482113	52617314	52617315	10700	hg38	N/A	enh23304	N/A	Enhatls151884	enhancer	E5274	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13757	0.9502		TRAM2	chr6	52497407	52577060	31768	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3656
enhrx-53704	chr15	27706152	27706153	27461006	27461007	10701	hg38	N/A	N/A	N/A	Enhatls57862	enhancer	E5275	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15105	0.9502		GABRG3	chr15	26971180	27541984	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	406
enhrx-27879	chr11	34778911	34778912	34757364	34757365	10702	hg38	N/A	enh43526	N/A	Enhatls30341	enhancer	E5276	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20599	0.95035		EHF	chr11	34621092	34663288	84491	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2548
enhrx-114232	chr3	45439840	45439841	45398348	45398349	10703	hg38	N/A	N/A	N/A	Enhatls122237	enhancer	E5277	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050087	0.95041		LARS2	chr3	45388560	45554726	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2361
enhrx-119193	chr3	133705247	133705248	133986403	133986404	10704	hg38	N/A	enh65760	N/A	Enhatls127550	enhancer	E5278	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12275	0.95065		SLCO2A1	chr3	133932700	134029925	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7322
enhrx-146272	chr6	152894101	152894102	152572966	152572967	10705	hg38	N/A	enh59706	N/A	Enhatls156348	enhancer	E5279	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20269	0.95065		SYNE1	chr6	152121686	152637801	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7860
enhrx-45302	chr13	34027248	34027249	33453111	33453112	10706	hg38	N/A	enh30195	N/A	Enhatls48898	enhancer	E5280	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12573	0.95065		STARD13	chr13	33103136	33350630	99739	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	924
enhrx-41239	chr12	99655225	99655226	99261447	99261448	10707	hg38	N/A	enh29916	N/A	Enhatls44573	enhancer	E5281	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19749	0.95065		ANKS1B	chr12	98734683	99984936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6549
enhrx-164100	chr9	34512742	34512743	34512744	34512745	10708	hg38	N/A	N/A	N/A	Enhatls175223	enhancer	E5282	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.084201	0.95067		DNAI1	chr9	34458751	34520988	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1367
enhrx-125153	chr4	64583333	64583334	63717615	63717616	10709	hg38	N/A	N/A	N/A	Enhatls133901	enhancer	E5283	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18934	0.95076		TECRL	chr4	64275256	64409468	405188	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2697
enhrx-2469	chr1	21646295	21646296	21319802	21319803	10710	hg38	N/A	enh110	N/A	Enhatls2743	enhancer	E5284	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28618	0.95083		ECE1	chr1	21217246	21345572	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2468
enhrx-106774	chr21	33942254	33942255	32569944	32569945	10711	hg38	N/A	enh93079	N/A	Enhatls114165	enhancer	E5285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23285	0.95083		CFAP298-TCP10L	chr21	32566441	32612865	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	657
enhrx-106774	chr21	33942254	33942255	32569944	32569945	10712	hg38	N/A	enh93079	N/A	Enhatls114165	enhancer	E5285	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23285	0.95083		TCP10L	chr21	32573720	32587373	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	657
enhrx-88855	chr2	20408094	20408095	20208333	20208334	10713	hg38	N/A	enh5335	fant6157	Enhatls95191	enhancer	E5286	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1816	0.95083		SDC1	chr2	20200796	20225433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	781
enhrx-45795	chr13	43878768	43878769	43304632	43304633	10714	hg38	N/A	enh43913	N/A	Enhatls49423	enhancer	E5287	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20291	0.95088		ENOX1	chr13	43213129	43786972	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1417
enhrx-115746	chr3	54187463	54187464	54153436	54153437	10715	hg38	N/A	N/A	N/A	Enhatls123834	enhancer	E5288	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08588	0.95166		CACNA2D3	chr3	54122551	55074557	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3875
enhrx-105742	chr20	61382206	61382207	62750854	62750855	10716	hg38	N/A	enh86426	N/A	Enhatls113099	enhancer	E5289	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035527	0.95177		NTSR1	chr20	62708835	62762771	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4170
enhrx-145069	chr6	130268091	130268092	129946946	129946947	10717	hg38	N/A	enh72504	N/A	Enhatls155023	enhancer	E5290	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035811	0.95177		L3MBTL3	chr6	130013698	130141449	64702	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6657
enhrx-22336	chr10	95506855	95506856	93747098	93747099	10718	hg38	N/A	enh13413	N/A	Enhatls24566	enhancer	E5291	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11718	0.95177		LGI1	chr10	93757850	93806134	6173	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4771
enhrx-51881	chr14	89507687	89507688	89041343	89041344	10719	hg38	N/A	enh15830	N/A	Enhatls55943	enhancer	E5292	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19799	0.95183		FOXN3	chr14	89124870	89619149	83441	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3838
enhrx-76965	chr18	20840789	20840790	23260825	23260826	10720	hg38	N/A	N/A	N/A	Enhatls82585	enhancer	E5293	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13917	0.95212		CABLES1	chr18	23134563	23260470	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	983
enhrx-120073	chr3	151023101	151023102	151305313	151305314	10721	hg38	N/A	enh21040	N/A	Enhatls128468	enhancer	E5294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12415	0.95223		MED12L	chr3	151085663	151437072	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8202
enhrx-120073	chr3	151023101	151023102	151305313	151305314	10722	hg38	N/A	enh21040	N/A	Enhatls128468	enhancer	E5294	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12415	0.95223		GPR87	chr3	151294085	151316820	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8202
enhrx-32335	chr11	95192451	95192452	95459287	95459288	10723	hg38	N/A	enh62189	N/A	Enhatls35112	enhancer	E5295	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13371	0.95235		SESN3	chr11	95165512	95232541	224725	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7004
enhrx-163579	chr9	20391375	20391376	20391377	20391378	10724	hg38	N/A	N/A	N/A	Enhatls174667	enhancer	E5296	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045812	0.95235		MLLT3	chr9	20341668	20622499	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	846
enhrx-118352	chr3	124560571	124560572	124841724	124841725	10725	hg38	N/A	N/A	N/A	Enhatls126641	enhancer	E5297	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12089	0.95235		ITGB5	chr3	124761947	124901418	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6481
enhrx-157733	chr8	27930476	27930477	28072959	28072960	10726	hg38	N/A	N/A	N/A	Enhatls168501	enhancer	E5298	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10926	0.95235		NUGGC	chr8	28021963	28083936	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1524
enhrx-161892	chr8	134247087	134247088	133234844	133234845	10727	hg38	N/A	enh25338	N/A	Enhatls172926	enhancer	E5299	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14191	0.95235		CCN4	chr8	133191038	133231690	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5683
enhrx-148607	chr7	25138168	25138169	25098549	25098550	10728	hg38	N/A	N/A	N/A	Enhatls158812	enhancer	E5300	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053548	0.95249		CYCS	chr7	25118655	25125260	9133	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1419
enhrx-13396	chr1	183538488	183538489	183569353	183569354	10729	hg38	N/A	N/A	N/A	Enhatls14792	enhancer	E5301	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28902	0.95249		NCF2	chr1	183555561	183590905	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13395
enhrx-102492	chr20	14895002	14895003	14914356	14914357	10730	hg38	N/A	enh59068	N/A	Enhatls109590	enhancer	E5302	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16092	0.95249		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	920
enhrx-144600	chr6	117736268	117736269	117415105	117415106	10731	hg38	N/A	N/A	N/A	Enhatls154531	enhancer	E5303	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053796	0.95249		ROS1	chr6	117287352	117425942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6188
enhrx-76466	chr18	9814574	9814575	9814577	9814578	10732	hg38	N/A	N/A	N/A	Enhatls82061	enhancer	E5304	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23839	0.95249		RAB31	chr18	9708300	9862551	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	484
enhrx-171159	chrX	18049863	18049864	18031743	18031744	10733	hg38	N/A	enh26169	N/A	Enhatls183153	enhancer	E5305	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066618	0.95249		BEND2	chrX	18162930	18220886	128236	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	876
enhrx-39296	chr12	57022996	57022997	56629212	56629213	10734	hg38	N/A	enh2388	fant41943	Enhatls42486	enhancer	E5306	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10478	0.95249		BAZ2A	chr12	56595595	56636379	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4606
enhrx-109643	chr22	30932549	30932550	30536562	30536563	10735	hg38	N/A	N/A	N/A	Enhatls117323	enhancer	E5307	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17978	0.95279		SEC14L6	chr22	30522798	30546741	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1474
enhrx-111521	chr22	47856789	47856790	47461040	47461041	10736	hg38	N/A	enh97227	N/A	Enhatls119347	enhancer	E5308	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39388	0.95279		TBC1D22A	chr22	46762616	47175699	283298	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3352
enhrx-166961	chr9	110267297	110267298	107505016	107505017	10737	hg38	N/A	enh42160	fant33137	Enhatls178703	enhancer	E5309	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22312	0.95279		KLF4	chr9	107484851	107490482	14218	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-174184	chrX	81452513	81452514	82197064	82197065	10738	hg38	N/A	N/A	N/A	Enhatls186352	enhancer	E5310	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073387	0.95283		SH3BGRL	chrX	81202101	81298547	831500	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3901
enhrx-24103	chr10	117858860	117858861	116099349	116099350	10739	hg38	N/A	N/A	N/A	Enhatls26458	enhancer	E5311	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14463	0.95287		GFRA1	chr10	116056924	116276803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6538
enhrx-102955	chr20	24986062	24986063	25005426	25005427	10740	hg38	N/A	N/A	N/A	Enhatls110080	enhancer	E5312	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12708	0.95287		ACSS1	chr20	25006229	25058980	6	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1383
enhrx-118764	chr3	129231628	129231629	129512785	129512786	10741	hg38	N/A	N/A	N/A	Enhatls127096	enhancer	E5313	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2282	0.95287		IFT122	chr3	129440104	129520510	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6893
enhrx-80344	chr19	6056329	6056330	6056318	6056319	10742	hg38	N/A	enh17885	N/A	Enhatls86197	enhancer	E5314	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1425	0.95304		RFX2	chr19	5993163	6199529	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1314
enhrx-41450	chr12	102002324	102002325	101608546	101608547	10743	hg38	N/A	enh51374	N/A	Enhatls44789	enhancer	E5315	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.37191	0.95304		MYBPC1	chr12	101568352	101686028	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6760
enhrx-44963	chr13	28535036	28535037	27960899	27960900	10744	hg38	N/A	N/A	fant43955	Enhatls48505	enhancer	E5316	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23682	0.95304		CDX2	chr13	27960917	27969315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	585
enhrx-52445	chr14	96532163	96532164	96065826	96065827	10745	hg38	N/A	enh3425	N/A	Enhatls56567	enhancer	E5317	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20106	0.95354		C14orf132	chr14	96039361	96093971	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4402
enhrx-133911	chr5	90458703	90458704	91162886	91162887	10746	hg38	N/A	enh22423	fant19255	Enhatls143055	enhancer	E5318	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.01567	0.95354		ADGRV1	chr5	90529343	91164437	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3702
enhrx-52409	chr14	95664140	95664141	95197803	95197804	10747	hg38	N/A	enh3408	N/A	Enhatls56516	enhancer	E5319	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16377	0.95356		CLMN	chr14	95181939	95319908	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4366
enhrx-153354	chr7	110163076	110163077	110523019	110523020	10748	hg38	N/A	enh40480	N/A	Enhatls163876	enhancer	E5320	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1627	0.95377		IMMP2L	chr7	110662643	111562517	137466	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6166
enhrx-113077	chr3	25158883	25158884	25117392	25117393	10749	hg38	N/A	N/A	N/A	Enhatls120994	enhancer	E5321	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.143	0.95402		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1206
enhrx-99086	chr2	208712755	208712756	207848031	207848032	10750	hg38	N/A	enh34197	N/A	Enhatls106018	enhancer	E5322	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15022	0.95411		PLEKHM3	chr2	207821287	208025527	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11012
enhrx-89938	chr2	33295326	33295327	33070259	33070260	10751	hg38	N/A	enh18430	N/A	Enhatls96336	enhancer	E5323	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31287	0.95459		LTBP1	chr2	32946952	33399509	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1864
enhrx-18250	chr10	14338276	14338277	14296277	14296278	10752	hg38	N/A	enh27833	N/A	Enhatls19941	enhancer	E5324	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17253	0.95485		FRMD4A	chr10	13643705	14462142	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	685
enhrx-123677	chr4	17774316	17774317	17772693	17772694	10753	hg38	N/A	enh63289	N/A	Enhatls132359	enhancer	E5325	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11319	0.95485		FAM184B	chr4	17629305	17781621	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1221
enhrx-77154	chr18	22510997	22510998	24931033	24931034	10754	hg38	N/A	enh109803	N/A	Enhatls82801	enhancer	E5326	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15929	0.95485		ZNF521	chr18	25061923	25352166	128673	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1172
enhrx-93429	chr2	101223023	101223024	100606561	100606562	10755	hg38	N/A	enh5742	N/A	Enhatls100062	enhancer	E5327	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.075592	0.95504		PDCL3	chr2	100562992	100576739	26994	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5355
enhrx-89690	chr2	30909000	30909001	30686134	30686135	10756	hg38	N/A	enh33185	N/A	Enhatls96075	enhancer	E5328	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20164	0.95507		CAPN13	chr2	30722770	30807446	25742	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1616
enhrx-4280	chr1	37950355	37950356	37484754	37484755	10757	hg38	N/A	enh11745	N/A	Enhatls4716	enhancer	E5329	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16669	0.95507		ZC3H12A	chr1	37474579	37484377	3	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4279
enhrx-24737	chr10	126379745	126379746	124691176	124691177	10758	hg38	N/A	enh1580	N/A	Enhatls27083	enhancer	E5330	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058356	0.95507		FAM53B	chr10	124619291	124744378	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7172
enhrx-157685	chr8	27543472	27543473	27685955	27685956	10759	hg38	N/A	enh24871	N/A	Enhatls168450	enhancer	E5331	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2083	0.95535		SCARA3	chr8	27633867	27676776	4753	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1476
enhrx-99499	chr2	216283447	216283448	215418724	215418725	10760	hg38	N/A	N/A	N/A	Enhatls106440	enhancer	E5332	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10327	0.95536		FN1	chr2	215360439	215436073	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11425
enhrx-39905	chr12	66539049	66539050	66145269	66145270	10761	hg38	N/A	N/A	N/A	Enhatls43146	enhancer	E5333	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15894	0.95536		TMBIM4	chr12	66135845	66170012	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5215
enhrx-145960	chr6	149414986	149414987	149093850	149093851	10762	hg38	N/A	enh39658	N/A	Enhatls156016	enhancer	E5334	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19132	0.95539		UST	chr6	148747029	149076990	14700	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7548
enhrx-160670	chr8	102133033	102133034	101120805	101120806	10763	hg38	N/A	enh10456	N/A	Enhatls171616	enhancer	E5335	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21339	0.95558		ZNF706	chr8	101177877	101206193	55080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4461
enhrx-155974	chr7	155108622	155108623	155316912	155316913	10764	hg38	N/A	enh24677	N/A	Enhatls166640	enhancer	E5336	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1229	0.95591		INSIG1	chr7	155297775	155310235	3601	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8786
enhrx-77204	chr18	24266015	24266016	26686051	26686052	10765	hg38	N/A	N/A	N/A	Enhatls82855	enhancer	E5337	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11907	0.95591		KCTD1	chr18	26454909	26657401	5036	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1222
enhrx-112079	chr3	6167341	6167342	6125654	6125655	10766	hg38	N/A	N/A	N/A	Enhatls119933	enhancer	E5338	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.04712	0.9562		GRM7	chr3	6770068	7741533	598886	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	208
enhrx-88190	chr2	3226634	3226635	3222863	3222864	10767	hg38	N/A	enh96857	fant5735	Enhatls94434	enhancer	E5339	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092151	0.95635		EIPR1	chr2	3188924	3377830	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	116
enhrx-148268	chr7	18886451	18886452	18846828	18846829	10768	hg38	hs644	enh84549	N/A	Enhatls158450	enhancer	E5340	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10482	0.95637		HDAC9	chr7	18086948	19002416	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1080
enhrx-147036	chr6	168789642	168789643	168388962	168388963	10769	hg38	N/A	enh23889	N/A	Enhatls157160	enhancer	E5341	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.053336	0.95652		SMOC2	chr6	168441150	168667994	45876	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8624
enhrx-12052	chr1	165228579	165228580	165259342	165259343	10770	hg38	N/A	enh79233	N/A	Enhatls13353	enhancer	E5342	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23434	0.95652		LMX1A	chr1	165201866	165356715	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12051
enhrx-50962	chr14	71839425	71839426	71372708	71372709	10771	hg38	N/A	enh31008	N/A	Enhatls54963	enhancer	E5343	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050005	0.95652		SIPA1L1	chr14	71320475	71741229	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2919
enhrx-46632	chr13	74025725	74025726	73451588	73451589	10772	hg38	N/A	enh15385	N/A	Enhatls50348	enhancer	E5344	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21327	0.95652		KLF12	chr13	73686088	74134404	232331	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2254
enhrx-173811	chrX	71841168	71841169	72621318	72621319	10773	hg38	N/A	enh85720	N/A	Enhatls185987	enhancer	E5345	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.024749	0.9568		PHKA1	chrX	72578813	72714319	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3528
enhrx-96079	chr2	160058278	160058279	159201767	159201768	10774	hg38	N/A	enh18936	N/A	Enhatls102853	enhancer	E5346	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14908	0.95687		TANC1	chr2	158968639	159232659	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8005
enhrx-95252	chr2	135921067	135921068	135163497	135163498	10775	hg38	N/A	N/A	N/A	Enhatls101990	enhancer	E5347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23178	0.95687		RAB3GAP1	chr2	135052291	135170710	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7178
enhrx-95252	chr2	135921067	135921068	135163497	135163498	10776	hg38	N/A	N/A	N/A	Enhatls101990	enhancer	E5347	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23178	0.95687		ZRANB3	chr2	135136916	135531218	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7178
enhrx-42833	chr12	116712971	116712972	116275166	116275167	10777	hg38	N/A	enh51416	N/A	Enhatls46254	enhancer	E5348	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.033421	0.95691		MED13L	chr12	115958575	116277693	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8143
enhrx-116328	chr3	66762785	66762786	66712361	66712362	10778	hg38	N/A	enh97276	N/A	Enhatls124489	enhancer	E5349	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28536	0.95692		LRIG1	chr3	66378796	66501022	209380	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4457
enhrx-112102	chr3	8498244	8498245	8456558	8456559	10779	hg38	N/A	enh20308	N/A	Enhatls119959	enhancer	E5350	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11138	0.95692		LMCD1	chr3	8501806	8574668	43050	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	231
enhrx-171672	chrX	30976143	30976144	30958026	30958027	10780	hg38	N/A	enh26205	N/A	Enhatls183701	enhancer	E5351	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079927	0.95708		TAB3	chrX	30827441	30975084	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1389
enhrx-173422	chrX	66920606	66920607	67700764	67700765	10781	hg38	N/A	N/A	N/A	Enhatls185589	enhancer	E5352	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17217	0.95744		AR	chrX	67544020	67730619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3139
enhrx-171970	chrX	39944625	39944626	40085372	40085373	10782	hg38	N/A	enh11181	N/A	Enhatls184012	enhancer	E5353	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32309	0.95744		BCOR	chrX	40049814	40177329	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1687
enhrx-110795	chr22	41399305	41399306	41003301	41003302	10783	hg38	N/A	enh20220	N/A	Enhatls118565	enhancer	E5354	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15819	0.95744		RBX1	chr22	40951377	40973309	20653	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2626
enhrx-27996	chr11	39753721	39753722	39732171	39732172	10784	hg38	N/A	N/A	N/A	Enhatls30467	enhancer	E5355	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.059545	0.95769		LRRC4C	chr11	40114202	41459773	182988	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2665
enhrx-171596	chrX	26247445	26247446	26229328	26229329	10785	hg38	N/A	N/A	N/A	Enhatls183626	enhancer	E5356	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13554	0.95769		MAGEB5	chrX	26216168	26218270	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1313
enhrx-173427	chrX	67009562	67009563	67789720	67789721	10786	hg38	N/A	N/A	N/A	Enhatls185594	enhancer	E5357	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26766	0.95771		AR	chrX	67544020	67730619	53155	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3144
enhrx-126763	chr4	92761620	92761621	91840469	91840470	10787	hg38	N/A	N/A	N/A	Enhatls135596	enhancer	E5358	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19705	0.95815		CCSER1	chr4	90127393	91605295	226510	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-100181	chr2	227268371	227268372	226403655	226403656	10788	hg38	N/A	enh34356	N/A	Enhatls107182	enhancer	E5359	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2143	0.95816		IRS1	chr2	226731311	226799820	321296	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12107
enhrx-107237	chr21	40443931	40443932	39072005	39072006	10789	hg38	N/A	enh93086	N/A	Enhatls114681	enhancer	E5360	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.37846	0.95829		PSMG1	chr21	39174768	39183488	98840	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1120
enhrx-98258	chr2	197394924	197394925	196530200	196530201	10790	hg38	N/A	enh97038	N/A	Enhatls105127	enhancer	E5361	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.062758	0.95841		HECW2	chr2	196194071	196593554	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10184
enhrx-116457	chr3	71136626	71136627	71087475	71087476	10791	hg38	N/A	enh7308	N/A	Enhatls124625	enhancer	E5362	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.272	0.95842		FOXP1	chr3	70954692	71583978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4586
enhrx-56651	chr15	62862525	62862526	62570326	62570327	10792	hg38	N/A	enh52039	N/A	Enhatls60946	enhancer	E5363	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.019831	0.95852		TLN2	chr15	62390549	62844631	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3353
enhrx-147028	chr6	168597316	168597317	168196636	168196637	10793	hg38	N/A	enh23884	N/A	Enhatls157151	enhancer	E5364	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17302	0.95852		FRMD1	chr6	168053094	168101511	88495	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8616
enhrx-68568	chr17	13086295	13086296	13182978	13182979	10794	hg38	N/A	enh96733	N/A	Enhatls73584	enhancer	E5365	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20906	0.95852		ELAC2	chr17	12991611	13018065	162804	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1837
enhrx-170756	chrX	10001430	10001431	10033390	10033391	10795	hg38	N/A	enh42372	N/A	Enhatls182721	enhancer	E5366	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.058379	0.95852		WWC3	chrX	10015253	10144474	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	473
enhrx-155986	chr7	155451480	155451481	155658786	155658787	10796	hg38	N/A	enh10107	N/A	Enhatls166653	enhancer	E5367	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16519	0.95852		RBM33	chr7	155644450	155781485	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8798
enhrx-49017	chr14	34729371	34729372	34260165	34260166	10797	hg38	N/A	enh15569	N/A	Enhatls52919	enhancer	E5368	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16041	0.95856		EGLN3	chr14	33924226	34222877	26823	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	974
enhrx-98407	chr2	198707769	198707770	197843045	197843046	10798	hg38	N/A	N/A	N/A	Enhatls105286	enhancer	E5369	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14722	0.95857		PLCL1	chr2	197804592	198149863	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	10333
enhrx-83381	chr19	30162330	30162331	29671423	29671424	10799	hg38	N/A	enh18006	N/A	Enhatls89431	enhancer	E5370	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21085	0.95857		PLEKHF1	chr19	29665458	29675477	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4351
enhrx-82242	chr19	15606063	15606064	15495252	15495253	10800	hg38	N/A	N/A	N/A	Enhatls88184	enhancer	E5371	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15557	0.95905		PGLYRP2	chr19	15468644	15498956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3212
enhrx-104212	chr20	39587494	39587495	40958854	40958855	10801	hg38	N/A	enh62990	N/A	Enhatls111460	enhancer	E5372	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1874	0.95914		TOP1	chr20	41028821	41124487	63312	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2640
enhrx-20392	chr10	62135578	62135579	60375820	60375821	10802	hg38	N/A	enh28130	N/A	Enhatls22464	enhancer	E5373	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17819	0.95924		ANK3	chr10	60026297	60733490	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2827
enhrx-143755	chr6	99658887	99658888	99211011	99211012	10803	hg38	N/A	N/A	N/A	Enhatls153632	enhancer	E5374	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26548	0.95924		FAXC	chr6	99271167	99349674	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5343
enhrx-136546	chr5	148926694	148926695	149547131	149547132	10804	hg38	N/A	enh8789	N/A	Enhatls145879	enhancer	E5375	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10761	0.95924		CSNK1A1	chr5	149492981	149551439	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6337
enhrx-77409	chr18	29952653	29952654	32372690	32372691	10805	hg38	N/A	enh17628	fant54824	Enhatls83065	enhancer	E5376	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17715	0.95945		GAREM1	chr18	32124876	32470882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1427
enhrx-137697	chr5	174063286	174063287	174636283	174636284	10806	hg38	N/A	enh22843	N/A	Enhatls147175	enhancer	E5377	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18394	0.95945		MSX2	chr5	174724581	174730896	84910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7488
enhrx-79208	chr19	935026	935027	935026	935027	10807	hg38	N/A	enh4948	fant55744	Enhatls84971	enhancer	E5378	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.034958	0.95945		ARID3A	chr19	926034	975939	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	178
enhrx-91460	chr2	68025019	68025020	67797887	67797888	10808	hg38	N/A	enh5617	N/A	Enhatls98010	enhancer	E5379	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14095	0.95959		C1D	chr2	68041129	68063009	238727	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3386
enhrx-173430	chrX	67271413	67271414	68051571	68051572	10809	hg38	N/A	N/A	N/A	Enhatls185597	enhancer	E5380	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16031	0.95967		OPHN1	chrX	67949348	68433913	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3147
enhrx-77199	chr18	24145162	24145163	26565198	26565199	10810	hg38	N/A	N/A	N/A	Enhatls82851	enhancer	E5381	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.085346	0.95972		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1217
enhrx-100917	chr2	235275711	235275712	234367067	234367068	10811	hg38	N/A	enh19340	N/A	Enhatls107953	enhancer	E5382	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015321	0.95973		ARL4C	chr2	234493040	234497081	111030	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12843
enhrx-158465	chr8	41841536	41841537	41984018	41984019	10812	hg38	N/A	enh56662	N/A	Enhatls169297	enhancer	E5383	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051397	0.95973		KAT6A	chr8	41929478	42051994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2256
enhrx-73089	chr17	56756874	56756875	58679513	58679514	10813	hg38	N/A	enh81237	N/A	Enhatls78463	enhancer	E5384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30091	0.95995		TEX14	chr17	58556677	58692055	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6358
enhrx-73089	chr17	56756874	56756875	58679513	58679514	10814	hg38	N/A	enh81237	N/A	Enhatls78463	enhancer	E5384	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30091	0.95995		IGBP1C	chr17	58660423	58692045	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6358
enhrx-7799	chr1	92025601	92025602	91560044	91560045	10815	hg38	N/A	enh12029	N/A	Enhatls8434	enhancer	E5385	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29595	0.96002		CDC7	chr1	91500850	91525764	23447	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7798
enhrx-150142	chr7	62501999	62502000	63041621	63041622	10816	hg38	N/A	N/A	N/A	Enhatls160490	enhancer	E5386	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31376	0.96002		ZNF722	chr7	63998848	64018081	848845	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2954
enhrx-95673	chr2	151793690	151793691	150937176	150937177	10817	hg38	N/A	enh81918	N/A	Enhatls102435	enhancer	E5387	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15749	0.96011		RBM43	chr2	151247939	151261863	307079	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7599
enhrx-148212	chr7	17170077	17170078	17130453	17130454	10818	hg38	N/A	N/A	fant25655	Enhatls158385	enhancer	E5388	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038968	0.96017		AHR	chr7	17132189	17346150	1614	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1024
enhrx-163223	chr9	12414639	12414640	12414639	12414640	10819	hg38	N/A	N/A	N/A	Enhatls174295	enhancer	E5389	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24056	0.96017		TYRP1	chr9	12685438	12710285	263479	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	490
enhrx-63591	chr16	48161280	48161281	48127369	48127370	10820	hg38	N/A	N/A	N/A	Enhatls68270	enhancer	E5390	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.013215	0.96018		ABCC12	chr16	48080881	48155993	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3886
enhrx-18143	chr10	12827711	12827712	12785712	12785713	10821	hg38	N/A	enh62010	N/A	Enhatls19831	enhancer	E5391	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11845	0.96018		CAMK1D	chr10	12349546	12835545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	578
enhrx-88252	chr2	5583095	5583096	5442962	5442963	10822	hg38	N/A	N/A	N/A	Enhatls94509	enhancer	E5392	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23334	0.96031		SOX11	chr2	5692383	5701385	240571	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	178
enhrx-40098	chr12	70015525	70015526	69621745	69621746	10823	hg38	N/A	enh64612	N/A	Enhatls43355	enhancer	E5393	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33749	0.96031		LRRC10	chr12	69608563	69610907	6163	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5408
enhrx-30454	chr11	66795369	66795370	67027898	67027899	10824	hg38	N/A	enh1844	N/A	Enhatls33082	enhancer	E5394	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15441	0.96031		SYT12	chr11	67006777	67050863	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5123
enhrx-114372	chr3	46707547	46707548	46666057	46666058	10825	hg38	N/A	enh54116	N/A	Enhatls122388	enhancer	E5395	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18226	0.96055		ALS2CL	chr3	46668994	46693679	250	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2501
enhrx-129393	chr4	166381259	166381260	165460107	165460108	10826	hg38	N/A	enh21917	N/A	Enhatls138316	enhancer	E5396	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19798	0.96069		CPE	chr4	165361193	165498547	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6937
enhrx-117420	chr3	111456763	111456764	111737916	111737917	10827	hg38	N/A	enh7444	N/A	Enhatls125663	enhancer	E5397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17994	0.96069		PLCXD2	chr3	111674675	111846447	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-117420	chr3	111456763	111456764	111737916	111737917	10828	hg38	N/A	enh7444	N/A	Enhatls125663	enhancer	E5397	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17994	0.96069		PHLDB2	chr3	111732496	111976517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-85922	chr19	47428646	47428647	46925389	46925390	10829	hg38	N/A	enh5183	N/A	Enhatls92096	enhancer	E5398	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.027406	0.961		ARHGAP35	chr19	46860996	47005077	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6892
enhrx-151578	chr7	91195198	91195199	91565883	91565884	10830	hg38	N/A	enh72883	fant27000	Enhatls162042	enhancer	E5399	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13354	0.96146		FZD1	chr7	91264432	91271326	294485	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4390
enhrx-95858	chr2	152616781	152616782	151760267	151760268	10831	hg38	N/A	enh5921	N/A	Enhatls102620	enhancer	E5400	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27351	0.96151		NEB	chr2	151485335	151734487	14045	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7784
enhrx-33328	chr11	116679137	116679138	116808421	116808422	10832	hg38	N/A	enh14302	N/A	Enhatls36164	enhancer	E5401	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26147	0.96152		APOA4	chr11	116820699	116823304	11772	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7997
enhrx-127308	chr4	106845732	106845733	105924575	105924576	10833	hg38	N/A	enh54899	N/A	Enhatls136159	enhancer	E5402	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32675	0.96174		NPNT	chr4	105894774	106004027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4852
enhrx-90164	chr2	38401968	38401969	38174826	38174827	10834	hg38	N/A	enh18456	fant6645	Enhatls96588	enhancer	E5403	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22732	0.96212		CYP1B1	chr2	38067508	38109902	64504	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2090
enhrx-166108	chr9	95895658	95895659	93133376	93133377	10835	hg38	N/A	N/A	N/A	Enhatls177778	enhancer	E5404	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13574	0.96212		NINJ1	chr9	93121495	93134251	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3375
enhrx-137695	chr5	173910557	173910558	174483554	174483555	10836	hg38	N/A	enh97802	N/A	Enhatls147171	enhancer	E5405	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12108	0.96212		MSX2	chr5	174724581	174730896	238910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7486
enhrx-24103	chr10	117864256	117864257	116104745	116104746	10837	hg38	N/A	N/A	N/A	Enhatls26458	enhancer	E5406	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21616	0.96235		GFRA1	chr10	116056924	116276803	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6538
enhrx-76937	chr18	20193500	20193501	22613537	22613538	10838	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	E5407	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054004	0.96251		RBBP8	chr18	22798260	23026488	174779	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	955
enhrx-95546	chr2	144772835	144772836	144015268	144015269	10839	hg38	N/A	enh33740	N/A	Enhatls102285	enhancer	E5408	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.215	0.96251		GTDC1	chr2	143938067	144332534	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7472
enhrx-2903	chr1	25029525	25029526	24703034	24703035	10840	hg38	N/A	enh139	N/A	Enhatls3232	enhancer	E5409	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16679	0.96254		SRRM1	chr1	24641230	24673281	27174	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2902
enhrx-102715	chr20	19693459	19693460	19712815	19712816	10841	hg38	N/A	enh6307	N/A	Enhatls109829	enhancer	E5410	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051212	0.96254		SLC24A3	chr20	19212641	19722926	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1143
enhrx-124052	chr4	37482432	37482433	37480810	37480811	10842	hg38	N/A	enh21426	N/A	Enhatls132752	enhancer	E5411	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11716	0.96254		C4orf19	chr4	37453924	37623495	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1596
enhrx-165522	chr9	83936172	83936173	81321257	81321258	10843	hg38	N/A	enh25638	N/A	Enhatls177133	enhancer	E5412	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29857	0.96284		TLE1	chr9	81583682	81689547	260343	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-75301	chr17	77871559	77871560	79897760	79897761	10844	hg38	N/A	N/A	N/A	Enhatls80822	enhancer	E5413	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28412	0.96284		TBC1D16	chr17	79932342	80035872	31777	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8570
enhrx-166918	chr9	109103165	109103166	106340884	106340885	10845	hg38	N/A	N/A	N/A	Enhatls178653	enhancer	E5414	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13938	0.96288		ZNF462	chr9	106863165	107013634	488342	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4185
enhrx-77668	chr18	39490094	39490095	41910129	41910130	10846	hg38	N/A	N/A	N/A	Enhatls83330	enhancer	E5415	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15815	0.96288		PIK3C3	chr18	41955233	42087830	30714	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1686
enhrx-27986	chr11	38406638	38406639	38385088	38385089	10847	hg38	N/A	enh79875	N/A	Enhatls30456	enhancer	E5416	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29775	0.96288		IFTAP	chr11	36594368	36659291	1723345	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2655
enhrx-133037	chr5	72693731	72693732	73397904	73397905	10848	hg38	N/A	N/A	N/A	Enhatls142154	enhancer	E5417	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22279	0.96288		FOXD1	chr5	73446265	73448777	36262	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2828
enhrx-44869	chr13	26174305	26174306	25600167	25600168	10849	hg38	N/A	N/A	N/A	Enhatls48406	enhancer	E5418	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.05341	0.96288		ATP8A2	chr13	25371973	26025851	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	491
enhrx-157592	chr8	26308922	26308923	26451406	26451407	10850	hg38	N/A	enh10193	N/A	Enhatls168358	enhancer	E5419	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14079	0.963		BNIP3L	chr8	26383053	26505636	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1383
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10851	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA10	chr5	140855882	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10852	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHAC1	chr5	140926298	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10853	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA13	chr5	140882123	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10854	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA12	chr5	140875301	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10855	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA11	chr5	140868182	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10856	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHAC2	chr5	140966469	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10857	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA9	chr5	140847771	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10858	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA5	chr5	140821603	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10859	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA7	chr5	140834247	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10860	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA1	chr5	140786135	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10861	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA2	chr5	140794851	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10862	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA8	chr5	140841186	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10863	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA4	chr5	140807036	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10864	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA6	chr5	140827957	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-136055	chr5	140357969	140357970	140978384	140978385	10865	hg38	N/A	N/A	N/A	Enhatls145343	enhancer	E5420	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.963		PCDHA3	chr5	140801027	141012347	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5846
enhrx-135026	chr5	126015740	126015741	126680048	126680049	10866	hg38	N/A	enh8647	N/A	Enhatls144242	enhancer	E5421	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22315	0.96327		SPMIP10	chr5	126631704	126636284	35999	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4817
enhrx-49102	chr14	35765200	35765201	35295994	35295995	10867	hg38	N/A	enh3094	N/A	Enhatls53005	enhancer	E5422	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086303	0.96327		PSMA6	chr14	35278632	35317493	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1059
enhrx-176664	chrX	138046409	138046410	138964247	138964248	10868	hg38	N/A	N/A	N/A	Enhatls188900	enhancer	E5423	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25078	0.96327		FGF13	chrX	138614726	139222777	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6381
enhrx-13402	chr1	183575216	183575217	183606081	183606082	10869	hg38	N/A	enh804	N/A	Enhatls14798	enhancer	E5424	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1153	0.96346		ARPC5	chr1	183620845	183635783	13572	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13401
enhrx-41422	chr12	101754697	101754698	101360919	101360920	10870	hg38	N/A	N/A	N/A	Enhatls44762	enhancer	E5425	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089782	0.96346		UTP20	chr12	101280104	101386618	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6732
enhrx-163575	chr9	20321030	20321031	20321032	20321033	10871	hg38	N/A	enh41786	N/A	Enhatls174661	enhancer	E5426	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22262	0.96351		MLLT3	chr9	20341668	20622499	19810	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	842
enhrx-127834	chr4	120014345	120014346	119093190	119093191	10872	hg38	N/A	enh21752	N/A	Enhatls136705	enhancer	E5427	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079631	0.96359		SYNPO2	chr4	118850687	119061247	29844	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5378
enhrx-23489	chr10	105708497	105708498	103948739	103948740	10873	hg38	N/A	enh96136	N/A	Enhatls25792	enhancer	E5428	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086674	0.9638		SLK	chr10	103967139	104029233	15283	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5924
enhrx-141343	chr6	42757595	42757596	42789857	42789858	10874	hg38	N/A	enh9127	N/A	Enhatls151104	enhancer	E5429	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16324	0.9638		BICRAL	chr6	42782051	42868558	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2931
enhrx-26291	chr11	7599285	7599286	7578054	7578055	10875	hg38	N/A	enh13725	N/A	Enhatls28655	enhancer	E5430	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077814	0.9638		PPFIBP2	chr11	7513297	7657078	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	960
enhrx-20233	chr10	55646569	55646570	53886809	53886810	10876	hg38	N/A	enh96080	N/A	Enhatls22295	enhancer	E5431	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19841	0.9638		PCDH15	chr10	53802770	55627942	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2668
enhrx-78764	chr18	68917158	68917159	71249922	71249923	10877	hg38	N/A	N/A	N/A	Enhatls84502	enhancer	E5432	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20378	0.96381		SOCS6	chr18	70289044	70330199	866542	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2782
enhrx-88458	chr2	10411049	10411050	10270923	10270924	10878	hg38	N/A	enh18261	N/A	Enhatls94759	enhancer	E5433	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0041714	0.96386		HPCAL1	chr2	10302888	10427617	24764	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	384
enhrx-26995	chr11	17461206	17461207	17439659	17439660	10879	hg38	N/A	enh50742	N/A	Enhatls29424	enhancer	E5434	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.022904	0.96405		ABCC8	chr11	17392497	17476872	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1664
enhrx-69885	chr17	29274818	29274819	30947800	30947801	10880	hg38	N/A	N/A	N/A	Enhatls75019	enhancer	E5435	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.41351	0.96406		ADAP2	chr17	30921916	30959322	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3154
enhrx-113220	chr3	29481924	29481925	29440433	29440434	10881	hg38	N/A	enh35302	N/A	Enhatls121147	enhancer	E5436	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12779	0.96406		RBMS3	chr3	28576174	30010391	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1349
enhrx-74267	chr17	71304542	71304543	73308403	73308404	10882	hg38	N/A	N/A	fant53663	Enhatls79729	enhancer	E5437	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09336	0.9642		CDC42EP4	chr17	73283623	73312001	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7536
enhrx-123814	chr4	24585253	24585254	24583630	24583631	10883	hg38	N/A	N/A	N/A	Enhatls132501	enhancer	E5438	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09868	0.96456		DHX15	chr4	24527474	24584554	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1358
enhrx-88879	chr2	20695986	20695987	20496226	20496227	10884	hg38	N/A	enh18333	N/A	Enhatls95214	enhancer	E5439	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038851	0.96456		RHOB	chr2	20447073	20449440	41662	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	805
enhrx-74310	chr17	72133816	72133817	74137677	74137678	10885	hg38	N/A	enh96769	N/A	Enhatls79785	enhancer	E5440	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13723	0.96456		RPL38	chr17	74203581	74210655	63806	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7579
enhrx-101056	chr2	238642698	238642699	237734055	237734056	10886	hg38	N/A	enh34436	N/A	Enhatls108099	enhancer	E5441	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27708	0.96456		LRRFIP1	chr2	237627586	237781643	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12982
enhrx-160449	chr8	99032779	99032780	98020551	98020552	10887	hg38	N/A	N/A	N/A	Enhatls171389	enhancer	E5442	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.030759	0.96456		MATN2	chr8	97868839	98036724	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4240
enhrx-134851	chr5	119287206	119287207	119951511	119951512	10888	hg38	N/A	enh71963	N/A	Enhatls144048	enhancer	E5443	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21952	0.96456		FAM170A	chr5	119629557	119635822	311896	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4642
enhrx-144248	chr6	110651107	110651108	110329904	110329905	10889	hg38	N/A	enh39322	N/A	Enhatls154161	enhancer	E5444	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18122	0.96456		METTL24	chr6	110243939	110358349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5836
enhrx-15426	chr1	214756591	214756592	214583248	214583249	10890	hg38	N/A	enh918	N/A	Enhatls16960	enhancer	E5445	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19606	0.96464		CENPF	chr1	214603194	214664571	13743	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15425
enhrx-120313	chr3	156938893	156938894	157221104	157221105	10891	hg38	N/A	N/A	N/A	Enhatls128733	enhancer	E5446	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.045925	0.96471		VEPH1	chr3	157259741	157533619	37486	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8442
enhrx-105299	chr20	55333928	55333929	56758872	56758873	10892	hg38	N/A	enh19782	N/A	Enhatls112614	enhancer	E5447	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.025457	0.96495		TFAP2C	chr20	56629305	56639283	107007	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3727
enhrx-130933	chr5	16493660	16493661	16493551	16493552	10893	hg38	N/A	enh22070	N/A	Enhatls139952	enhancer	E5448	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12038	0.96518		RETREG1	chr5	16473052	16617101	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	724
enhrx-59595	chr15	101757930	101757931	101217725	101217726	10894	hg38	N/A	enh16480	N/A	Enhatls64170	enhancer	E5449	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.092859	0.96518		CHSY1	chr15	101175726	101252048	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6297
enhrx-163819	chr9	27356862	27356863	27356864	27356865	10895	hg38	N/A	N/A	N/A	Enhatls174932	enhancer	E5450	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12099	0.96518		MOB3B	chr9	27325208	27529814	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1086
enhrx-165504	chr9	82283232	82283233	79668317	79668318	10896	hg38	N/A	enh95796	N/A	Enhatls177113	enhancer	E5451	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24858	0.96518		TLE4	chr9	79571772	79726882	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2771
enhrx-99574	chr2	217404527	217404528	216539804	216539805	10897	hg38	N/A	enh19216	N/A	Enhatls106529	enhancer	E5452	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.014378	0.96518		RPL37A	chr2	216498843	216579180	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11500
enhrx-175480	chrX	109195408	109195409	109952180	109952181	10898	hg38	N/A	enh85810	N/A	Enhatls187667	enhancer	E5453	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21905	0.96518		TMEM164	chrX	110002634	110177788	47691	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5197
enhrx-169133	chr9	134469802	134469803	131594415	131594416	10899	hg38	N/A	N/A	N/A	Enhatls181047	enhancer	E5454	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18027	0.96519		RAPGEF1	chr9	131576769	131740076	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6400
enhrx-123692	chr4	17847973	17847974	17846350	17846351	10900	hg38	N/A	N/A	N/A	Enhatls132374	enhancer	E5455	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27617	0.9655		LCORL	chr4	17841186	18021876	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1236
enhrx-110725	chr22	40784050	40784051	40388046	40388047	10901	hg38	N/A	N/A	N/A	Enhatls118493	enhancer	E5456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2197	0.9655		ADSL	chr22	40346460	40390463	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2556
enhrx-110725	chr22	40784050	40784051	40388046	40388047	10902	hg38	N/A	N/A	N/A	Enhatls118493	enhancer	E5456	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2197	0.9655		SGSM3	chr22	40370590	40410289	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2556
enhrx-35441	chr12	7123236	7123237	7015932	7015933	10903	hg38	N/A	N/A	N/A	Enhatls38472	enhancer	E5457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28971	0.9655		LPCAT3	chr12	6976184	7018476	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	751
enhrx-35441	chr12	7123236	7123237	7015932	7015933	10904	hg38	N/A	N/A	N/A	Enhatls38472	enhancer	E5457	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28971	0.9655		C1S	chr12	6988258	7071032	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	751
enhrx-49742	chr14	52988963	52988964	52522245	52522246	10905	hg38	N/A	enh112315	N/A	Enhatls53674	enhancer	E5458	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22352	0.96557		TXNDC16	chr14	52430595	52552505	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1699
enhrx-2110	chr1	18967617	18967618	18641123	18641124	10906	hg38	N/A	N/A	N/A	Enhatls2358	enhancer	E5459	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071023	0.96558		PAX7	chr1	18630845	18748866	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2109
enhrx-112080	chr3	6613311	6613312	6571624	6571625	10907	hg38	N/A	N/A	N/A	Enhatls119934	enhancer	E5460	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18572	0.96558		GRM7	chr3	6770068	7741533	163091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	209
enhrx-118319	chr3	124311741	124311742	124592894	124592895	10908	hg38	N/A	enh20876	N/A	Enhatls126600	enhancer	E5461	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20149	0.96558		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6448
enhrx-36326	chr12	16684831	16684832	16531897	16531898	10909	hg38	N/A	enh80087	N/A	Enhatls39396	enhancer	E5462	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17783	0.96566		LMO3	chr12	16548371	16610594	15851	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1636
enhrx-4738	chr1	42133249	42133250	41667578	41667579	10910	hg38	N/A	enh11793	N/A	Enhatls5199	enhancer	E5463	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25263	0.96566		HIVEP3	chr1	41506364	41918922	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4737
enhrx-61156	chr16	11323958	11323959	11230101	11230102	10911	hg38	N/A	enh47924	N/A	Enhatls65741	enhancer	E5464	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10395	0.96575		RMI2	chr16	11249648	11381662	18188	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1451
enhrx-2913	chr1	25468331	25468332	25141840	25141841	10912	hg38	N/A	enh47153	N/A	Enhatls3244	enhancer	E5465	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.49347	0.96629		SYF2	chr1	25222275	25232502	79612	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2912
enhrx-120995	chr3	178541543	178541544	178823755	178823756	10913	hg38	N/A	N/A	N/A	Enhatls129479	enhancer	E5466	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16266	0.96654		KCNMB2	chr3	178272931	178844429	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9124
enhrx-163372	chr9	15372252	15372253	15372254	15372255	10914	hg38	N/A	enh25481	N/A	Enhatls174453	enhancer	E5467	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10226	0.96697		SNAPC3	chr9	15422733	15465832	41113	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	639
enhrx-118317	chr3	124240090	124240091	124521243	124521244	10915	hg38	N/A	N/A	N/A	Enhatls126598	enhancer	E5468	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.138	0.96697		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6446
enhrx-150346	chr7	66916851	66916852	67451864	67451865	10916	hg38	N/A	N/A	N/A	Enhatls160722	enhancer	E5469	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072332	0.96698		SPDYE21	chr7	67276940	67289005	149144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3158
enhrx-133315	chr5	76578304	76578305	77282479	77282480	10917	hg38	N/A	enh88939	N/A	Enhatls142435	enhancer	E5470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011435	0.96698		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-133315	chr5	76578304	76578305	77282479	77282480	10918	hg38	N/A	enh88939	N/A	Enhatls142435	enhancer	E5470	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.011435	0.96698		PDE8B	chr5	77210448	77428256	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-144414	chr6	112971877	112971878	112650675	112650676	10919	hg38	N/A	enh91716	N/A	Enhatls154343	enhancer	E5471	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.35423	0.96701		RFPL4B	chr6	112347329	112351294	298150	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6002
enhrx-123812	chr4	24566880	24566881	24565257	24565258	10920	hg38	N/A	enh36472	N/A	Enhatls132499	enhancer	E5472	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.040332	0.96705		DHX15	chr4	24527474	24584554	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1356
enhrx-148226	chr7	17543647	17543648	17504023	17504024	10921	hg38	N/A	enh56185	N/A	Enhatls158403	enhancer	E5473	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15968	0.96705		AHR	chr7	17132189	17346150	155792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1038
enhrx-139164	chr6	18406310	18406311	18406079	18406080	10922	hg38	N/A	enh8988	N/A	Enhatls148775	enhancer	E5474	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23092	0.96712		RNF144B	chr6	18387349	18468870	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	752
enhrx-137204	chr5	159657895	159657896	160230888	160230889	10923	hg38	N/A	N/A	N/A	Enhatls146626	enhancer	E5475	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.028996	0.96725		FABP6	chr5	160187366	160238735	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6995
enhrx-149243	chr7	38262334	38262335	38222733	38222734	10924	hg38	N/A	enh49245	N/A	Enhatls159515	enhancer	E5476	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29993	0.9675		STARD3NL	chr7	38178244	38230669	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2055
enhrx-77152	chr18	22082791	22082792	24502827	24502828	10925	hg38	N/A	enh96792	N/A	Enhatls82797	enhancer	E5477	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25501	0.9675		HRH4	chr18	24460636	24479961	20721	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1170
enhrx-161248	chr8	120676281	120676282	119664041	119664042	10926	hg38	N/A	N/A	N/A	Enhatls172220	enhancer	E5478	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.060913	0.96776		ENPP2	chr8	119557085	119673453	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5039
enhrx-48208	chr14	21317471	21317472	20849312	20849313	10927	hg38	N/A	enh64764	N/A	Enhatls52053	enhancer	E5479	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031729	0.96776		RNASE3	chr14	20891384	20892348	36089	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	165
enhrx-92147	chr2	75819299	75819300	75592173	75592174	10928	hg38	N/A	enh18695	N/A	Enhatls98731	enhancer	E5480	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011263	0.96776		EVA1A	chr2	75492317	75569722	16272	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4073
enhrx-162827	chr9	899740	899741	899740	899741	10929	hg38	N/A	enh94759	N/A	Enhatls173895	enhancer	E5482	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12045	0.96776		DMRT1	chr9	841696	969090	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	94
enhrx-153954	chr7	127399931	127399932	127759877	127759878	10930	hg38	N/A	enh93659	N/A	Enhatls164521	enhancer	E5483	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15588	0.96776		SND1	chr7	127652193	128092593	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6766
enhrx-44503	chr13	20745696	20745697	20171557	20171558	10931	hg38	N/A	enh2706	N/A	Enhatls48018	enhancer	E5484	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.38345	0.96776		GJA3	chr13	20138254	20161052	10210	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	125
enhrx-146448	chr6	158407352	158407353	157986320	157986321	10932	hg38	N/A	enh23820	N/A	Enhatls156533	enhancer	E5485	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14758	0.96776		SYNJ2	chr6	157981862	158099176	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8036
enhrx-95866	chr2	152714309	152714310	151857795	151857796	10933	hg38	N/A	enh18906	N/A	Enhatls102629	enhancer	E5486	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19489	0.96784		CACNB4	chr2	151832770	152099167	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7792
enhrx-45092	chr13	31052037	31052038	30477900	30477901	10934	hg38	N/A	enh51498	N/A	Enhatls48655	enhancer	E5487	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27981	0.96855		HMGB1	chr13	30456703	30617597	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	714
enhrx-25121	chr10	134389128	134389129	132575624	132575625	10935	hg38	N/A	enh1596	fant37540	Enhatls27462	enhancer	E5488	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25405	0.96861		INPP5A	chr10	132537786	132783480	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7556
enhrx-41815	chr12	106306690	106306691	105912912	105912913	10936	hg38	N/A	enh80376	N/A	Enhatls45183	enhancer	E5489	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28222	0.96896		NUAK1	chr12	106063344	106138954	149108	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7125
enhrx-128469	chr4	141859214	141859215	140938060	140938061	10937	hg38	N/A	enh37114	fant16972	Enhatls137372	enhancer	E5490	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16795	0.96897		RNF150	chr4	140859806	141212877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6013
enhrx-111327	chr22	45586565	45586566	45190684	45190685	10938	hg38	N/A	N/A	N/A	Enhatls119124	enhancer	E5491	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15117	0.96897		NUP50	chr22	45163924	45188017	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3158
enhrx-123803	chr4	24520186	24520187	24518563	24518564	10939	hg38	N/A	enh36470	N/A	Enhatls132487	enhancer	E5492	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14432	0.969		DHX15	chr4	24527474	24584554	7288	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1347
enhrx-57526	chr15	72470599	72470600	72178258	72178259	10940	hg38	N/A	enh16309	N/A	Enhatls61893	enhancer	E5493	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.01743	0.96903		GRAMD2A	chr15	72159805	72197787	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4228
enhrx-2066	chr1	17891329	17891330	17564834	17564835	10941	hg38	N/A	enh11558	N/A	Enhatls2312	enhancer	E5494	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.008259	0.96903		ARHGEF10L	chr1	17539697	17697869	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2065
enhrx-79376	chr19	1415235	1415236	1415236	1415237	10942	hg38	N/A	enh32872	N/A	Enhatls85168	enhancer	E5495	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20883	0.96903		DAZAP1	chr19	1407568	1435687	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	346
enhrx-88795	chr2	19331811	19331812	19132050	19132051	10943	hg38	N/A	enh18314	N/A	Enhatls95132	enhancer	E5496	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17492	0.96903		OSR1	chr2	19351484	19358623	217331	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	721
enhrx-61064	chr16	9489859	9489860	9396002	9396003	10944	hg38	N/A	N/A	N/A	Enhatls65641	enhancer	E5497	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.055749	0.96945		HAPSTR1	chr16	9091643	9121635	259519	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-126215	chr4	82572179	82572180	81651025	81651026	10945	hg38	N/A	enh21631	N/A	Enhatls135028	enhancer	E5498	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20351	0.96953		RASGEF1B	chr4	81426392	82044244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3759
enhrx-141703	chr6	45522572	45522573	45554835	45554836	10946	hg38	N/A	enh39018	N/A	Enhatls151501	enhancer	E5499	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26695	0.96953		RUNX2	chr6	45328316	45664349	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3291
enhrx-23796	chr10	113813894	113813895	112054136	112054137	10947	hg38	N/A	N/A	N/A	Enhatls26118	enhancer	E5500	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23274	0.96953		GPAM	chr10	112149864	112183765	80038	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6231
enhrx-94040	chr2	111526426	111526427	110768849	110768850	10948	hg38	N/A	enh62831	N/A	Enhatls100713	enhancer	E5501	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25663	0.96962		ACOXL	chr2	110732538	111118548	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5966
enhrx-49454	chr14	49673459	49673460	49206741	49206742	10949	hg38	N/A	N/A	N/A	Enhatls53355	enhancer	E5502	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067356	0.96979		RPS29	chr14	49570983	49598690	323817	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1411
enhrx-101546	chr2	242701889	242701890	241762474	241762475	10950	hg38	N/A	enh82150	N/A	Enhatls108610	enhancer	E5503	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12112	0.96992		D2HGDH	chr2	241734601	241768811	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13472
enhrx-24768	chr10	126713003	126713004	125024434	125024435	10951	hg38	N/A	enh13606	N/A	Enhatls27119	enhancer	E5504	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25803	0.97018		CTBP2	chr10	124984316	125161061	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7203
enhrx-68842	chr17	17597286	17597287	17693972	17693973	10952	hg38	N/A	enh4277	fant52077	Enhatls73867	enhancer	E5505	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21296	0.9702		RAI1	chr17	17681457	17811453	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2111
enhrx-119382	chr3	137925949	137925950	138207107	138207108	10953	hg38	N/A	N/A	N/A	Enhatls127747	enhancer	E5506	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22835	0.97051		ARMC8	chr3	138187247	138298384	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7511
enhrx-8099	chr1	95468325	95468326	95002769	95002770	10954	hg38	N/A	enh26979	N/A	Enhatls8775	enhancer	E5507	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.031977	0.97051		ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8098
enhrx-131255	chr5	34450665	34450666	34450560	34450561	10955	hg38	N/A	enh97653	N/A	Enhatls140295	enhancer	E5508	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18043	0.9706		RAI14	chr5	34656327	34832612	201918	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1046
enhrx-106294	chr21	16143975	16143976	14771654	14771655	10956	hg38	N/A	enh6585	N/A	Enhatls113648	enhancer	E5509	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089094	0.97077		SAMSN1	chr21	14485227	14658821	101954	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	177
enhrx-134398	chr5	107675067	107675068	108339366	108339367	10957	hg38	N/A	N/A	N/A	Enhatls143567	enhancer	E5510	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20204	0.97077		FBXL17	chr5	107859034	108382098	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4189
enhrx-158900	chr8	54934113	54934114	54021553	54021554	10958	hg38	N/A	N/A	N/A	Enhatls169745	enhancer	E5511	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.080802	0.97077		TCEA1	chr8	53966551	54022448	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2691
enhrx-37658	chr12	45995725	45995726	45601942	45601943	10959	hg38	N/A	enh96289	N/A	Enhatls40776	enhancer	E5512	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.37662	0.97077		ARID2	chr12	45729705	45908040	126054	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2968
enhrx-89797	chr2	32213111	32213112	31988042	31988043	10960	hg38	N/A	enh33188	N/A	Enhatls96186	enhancer	E5513	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.011263	0.97077		MEMO1	chr2	31865059	32011230	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1723
enhrx-129160	chr4	157863323	157863324	156942171	156942172	10961	hg38	N/A	enh21899	fant17196	Enhatls138085	enhancer	E5514	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33968	0.97078		PDGFC	chr4	156760453	156971799	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6704
enhrx-157576	chr8	26123745	26123746	26266229	26266230	10962	hg38	N/A	enh24863	N/A	Enhatls168342	enhancer	E5515	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.016957	0.97097		PPP2R2A	chr8	26291507	26372680	24246	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1367
enhrx-9146	chr1	113564556	113564557	113021934	113021935	10963	hg38	N/A	enh58139	N/A	Enhatls9875	enhancer	E5516	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.046802	0.97108		LRIG2	chr1	113073197	113132260	48941	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9145
enhrx-124052	chr4	37529975	37529976	37528353	37528354	10964	hg38	N/A	enh21427	N/A	Enhatls132752	enhancer	E5517	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1553	0.97108		C4orf19	chr4	37453924	37623495	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1596
enhrx-68777	chr17	16980927	16980928	17077613	17077614	10965	hg38	N/A	N/A	N/A	Enhatls73799	enhancer	E5518	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21444	0.97108		MPRIP	chr17	17042456	17217679	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2046
enhrx-163723	chr9	25716350	25716351	25716352	25716353	10966	hg38	N/A	N/A	N/A	Enhatls174834	enhancer	E5519	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13849	0.97122		TUSC1	chr9	25676968	25678444	27518	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	990
enhrx-144018	chr6	107683331	107683332	107362127	107362128	10967	hg38	N/A	enh72443	N/A	Enhatls153905	enhancer	E5520	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12879	0.97122		PDSS2	chr6	107152561	107459564	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5606
enhrx-80165	chr19	4976575	4976576	4976564	4976565	10968	hg38	N/A	enh4974	fant56019	Enhatls86001	enhancer	E5521	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.079865	0.97152		KDM4B	chr19	4969112	5153598	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1135
enhrx-147988	chr7	8662731	8662732	8623101	8623102	10969	hg38	N/A	N/A	N/A	Enhatls158151	enhancer	E5522	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17884	0.97153		NXPH1	chr7	8433608	8752961	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	800
enhrx-165370	chr9	79201635	79201636	76586719	76586720	10970	hg38	N/A	enh10785	N/A	Enhatls176977	enhancer	E5523	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14249	0.97164		PRUNE2	chr9	76611375	76906114	22157	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2637
enhrx-123815	chr4	24682577	24682578	24680954	24680955	10971	hg38	N/A	enh21398	N/A	Enhatls132502	enhancer	E5524	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33157	0.97164		DHX15	chr4	24527474	24584554	93829	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-117348	chr3	108727686	108727687	109008839	109008840	10972	hg38	N/A	N/A	N/A	Enhatls125585	enhancer	E5525	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18322	0.97175		MORC1	chr3	108958247	109118134	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5477
enhrx-107187	chr21	39217989	39217990	37845687	37845688	10973	hg38	N/A	N/A	N/A	Enhatls114619	enhancer	E5526	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14635	0.97176		KCNJ6	chr21	37607372	38121345	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1070
enhrx-45088	chr13	30977843	30977844	30403706	30403707	10974	hg38	N/A	enh2751	N/A	Enhatls48648	enhancer	E5527	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27583	0.97213		UBE2L5	chr13	30422487	30429758	15913	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	710
enhrx-49822	chr14	54318649	54318650	53851931	53851932	10975	hg38	N/A	enh30894	N/A	Enhatls53754	enhancer	E5528	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23515	0.97213		BMP4	chr14	53949735	53958761	89059	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1779
enhrx-137369	chr5	167876380	167876381	168449375	168449376	10976	hg38	N/A	enh97795	N/A	Enhatls146801	enhancer	E5529	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1741	0.97229		WWC1	chr5	168291644	168472303	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7160
enhrx-31754	chr11	82554616	82554617	82843574	82843575	10977	hg38	N/A	N/A	N/A	Enhatls34502	enhancer	E5530	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30893	0.97248		PRCP	chr11	82822935	82970584	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6423
enhrx-141137	chr6	40682694	40682695	40714955	40714956	10978	hg38	N/A	enh23232	N/A	Enhatls150879	enhancer	E5531	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18449	0.97257		LRFN2	chr6	40391590	40587364	123401	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2725
enhrx-117132	chr3	103125426	103125427	103406582	103406583	10979	hg38	N/A	N/A	N/A	Enhatls125350	enhancer	E5532	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34152	0.97269		ZPLD1	chr3	102099243	102479841	910631	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5261
enhrx-46593	chr13	72701460	72701461	72127322	72127323	10980	hg38	N/A	enh30425	N/A	Enhatls50309	enhancer	E5533	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39014	0.97269		DACH1	chr13	71437965	71867204	253951	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2215
enhrx-127247	chr4	105888379	105888380	104967222	104967223	10981	hg38	N/A	enh21718	fant16518	Enhatls136097	enhancer	E5534	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1328	0.97273		TET2	chr4	105145874	105279816	178493	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4791
enhrx-132160	chr5	54897248	54897249	55601420	55601421	10982	hg38	N/A	enh22234	fant18526	Enhatls141244	enhancer	E5535	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24375	0.97273		SLC38A9	chr5	55625846	55712333	24248	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1951
enhrx-64011	chr16	56417080	56417081	56383168	56383169	10983	hg38	N/A	enh31815	N/A	Enhatls68704	enhancer	E5536	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.017259	0.97293		AMFR	chr16	56361451	56425545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4306
enhrx-75469	chr17	78496481	78496482	80522681	80522682	10984	hg38	N/A	N/A	N/A	Enhatls80989	enhancer	E5537	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1532	0.97337		RPTOR	chr17	80544837	80966368	21260	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8738
enhrx-147144	chr6	170536111	170536112	170226321	170226322	10985	hg38	N/A	enh46287	N/A	Enhatls157259	enhancer	E5538	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15972	0.97337		DLL1	chr6	170282205	170306565	42799	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8732
enhrx-127401	chr4	109039786	109039787	108118630	108118631	10986	hg38	N/A	enh48861	N/A	Enhatls136261	enhancer	E5539	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081169	0.97353		LEF1	chr4	108047544	108168956	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4945
enhrx-172380	chrX	47815647	47815648	47956248	47956249	10987	hg38	N/A	N/A	N/A	Enhatls184426	enhancer	E5540	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17689	0.97382		ZNF81	chrX	47836901	48002561	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2097
enhrx-70995	chr17	38738682	38738683	40582430	40582431	10988	hg38	N/A	enh48033	N/A	Enhatls76191	enhancer	E5541	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14018	0.97382		CCR7	chr17	40553768	40565472	12570	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4264
enhrx-101202	chr2	239946517	239946518	239024821	239024822	10989	hg38	N/A	enh34447	N/A	Enhatls108246	enhancer	E5542	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18177	0.97396		HDAC4	chr2	239048167	239401020	20708	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13128
enhrx-118717	chr3	128944144	128944145	129225301	129225302	10990	hg38	N/A	enh7525	N/A	Enhatls127036	enhancer	E5543	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15273	0.97399		COPG1	chr3	129249605	129277773	23111	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6846
enhrx-92381	chr2	85751973	85751974	85524850	85524851	10991	hg38	N/A	enh57756	N/A	Enhatls98978	enhancer	E5544	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31781	0.97421		MAT2A	chr2	85539167	85545281	12336	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4307
enhrx-151788	chr7	93633275	93633276	94003963	94003964	10992	hg38	N/A	N/A	N/A	Enhatls162257	enhancer	E5545	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11581	0.97443		BET1	chr7	93993244	94004382	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4600
enhrx-4434	chr1	39531455	39531456	39065783	39065784	10993	hg38	N/A	N/A	N/A	Enhatls4879	enhancer	E5546	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16911	0.97443		MACF1	chr1	39081315	39487177	4586	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4433
enhrx-163371	chr9	15304822	15304823	15304824	15304825	10994	hg38	N/A	N/A	N/A	Enhatls174452	enhancer	E5547	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1493	0.97443		TTC39B	chr9	15163621	15307360	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	638
enhrx-31828	chr11	84348320	84348321	84637277	84637278	10995	hg38	N/A	N/A	N/A	Enhatls34582	enhancer	E5548	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24302	0.97453		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6497
enhrx-8379	chr1	102656224	102656225	102190668	102190669	10996	hg38	N/A	enh74343	N/A	Enhatls9071	enhancer	E5549	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.042218	0.97479		OLFM3	chr1	101802559	101996926	184064	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8378
enhrx-157670	chr8	27453587	27453588	27596070	27596071	10997	hg38	N/A	N/A	N/A	Enhatls168435	enhancer	E5550	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22908	0.9748		CLU	chr8	27596916	27614700	4	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1461
enhrx-97926	chr2	190386893	190386894	189522167	189522168	10998	hg38	N/A	enh19084	N/A	Enhatls104780	enhancer	E5551	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24541	0.9748		SLC40A1	chr2	189560589	189583758	30161	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	9852
enhrx-23796	chr10	113732049	113732050	111972291	111972292	10999	hg38	N/A	N/A	N/A	Enhatls26118	enhancer	E5552	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13706	0.97502		GPAM	chr10	112149864	112183765	165539	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6231
enhrx-56647	chr15	62391723	62391724	62099524	62099525	11000	hg38	N/A	enh81008	N/A	Enhatls60942	enhancer	E5553	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.066267	0.97502		C2CD4A	chr15	62066976	62070917	26350	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3349
enhrx-80579	chr19	7145706	7145707	7145695	7145696	11001	hg38	N/A	enh96824	N/A	Enhatls86441	enhancer	E5554	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12645	0.97502		INSR	chr19	7112254	7294414	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1549
enhrx-168040	chr9	126440525	126440526	123678246	123678247	11002	hg38	N/A	enh25985	N/A	Enhatls179855	enhancer	E5555	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12064	0.9752		DENND1A	chr9	123379653	123930152	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5307
enhrx-137916	chr5	176766584	176766585	177339583	177339584	11003	hg38	N/A	N/A	N/A	Enhatls147418	enhancer	E5556	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10974	0.97545		LMAN2	chr5	177331566	177351676	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7707
enhrx-20997	chr10	73272903	73272904	71513146	71513147	11004	hg38	N/A	enh109434	N/A	N/A	enhancer	E5557	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.021068	0.97546		CDH23	chr10	71396919	71815947	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3432
enhrx-103162	chr20	30273907	30273908	31686104	31686105	11005	hg38	N/A	enh6337	N/A	Enhatls110296	enhancer	E5558	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089064	0.97546		BCL2L1	chr20	31664451	31723989	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1590
enhrx-lit82	chr10	126069689	126069690	124381120	124381121	11006	hg38					enhancer	E5559	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34204	0.97546							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-153231	chr7	107515195	107515196	107874750	107874751	11007	hg38	N/A	enh56430	N/A	Enhatls163747	enhancer	E5560	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16208	0.97582		DLD	chr7	107891172	107921198	11143	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6043
enhrx-155193	chr7	142793358	142793359	143096265	143096266	11008	hg38	N/A	enh61518	N/A	Enhatls165811	enhancer	E5561	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32877	0.97582		PIP	chr7	143132076	143139739	32563	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8005
enhrx-78876	chr18	73535664	73535665	75823709	75823710	11009	hg38	N/A	enh96813	N/A	Enhatls84617	enhancer	E5562	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15336	0.97585		SMIM21	chr18	75409475	75427703	393928	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2894
enhrx-96373	chr2	164070392	164070393	163213882	163213883	11010	hg38	N/A	enh33894	N/A	Enhatls103164	enhancer	E5563	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18274	0.97585		KCNH7	chr2	162371406	162838767	369669	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8299
enhrx-107891	chr21	46278847	46278848	44858932	44858933	11011	hg38	N/A	enh63052	N/A	Enhatls115375	enhancer	E5564	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21788	0.97589		PTTG1IP	chr21	44849584	44873903	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1774
enhrx-65686	chr16	75087937	75087938	75054039	75054040	11012	hg38	N/A	enh52322	N/A	Enhatls70485	enhancer	E5565	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24706	0.97608		ZNRF1	chr16	74999023	75110994	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5981
enhrx-58028	chr15	76961983	76961984	76669642	76669643	11013	hg38	N/A	N/A	N/A	Enhatls62430	enhancer	E5566	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.012469	0.97617		SCAPER	chr15	76347903	76905444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4730
enhrx-134554	chr5	111694811	111694812	112359114	112359115	11014	hg38	N/A	N/A	N/A	Enhatls143724	enhancer	E5567	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11581	0.97617		EPB41L4A	chr5	112162618	112419277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4345
enhrx-31892	chr11	85835516	85835517	86124474	86124475	11015	hg38	N/A	enh14164	N/A	Enhatls34649	enhancer	E5568	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29453	0.97637		PICALM	chr11	85957174	86069882	52462	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6561
enhrx-59393	chr15	96455015	96455016	95911786	95911787	11016	hg38	N/A	enh96640	N/A	Enhatls63955	enhancer	E5569	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14525	0.97642		NR2F2	chr15	96325937	96340263	413696	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6095
enhrx-44625	chr13	22122899	22122900	21548760	21548761	11017	hg38	N/A	enh108555	N/A	Enhatls48146	enhancer	E5570	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23386	0.97648		MICU2	chr13	21492690	21604181	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	247
enhrx-50570	chr14	65427776	65427777	64961058	64961059	11018	hg38	N/A	enh96521	N/A	Enhatls54546	enhancer	E5571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06277	0.97657		CHURC1-FNTB	chr14	64914492	65061361	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2527
enhrx-50570	chr14	65427776	65427777	64961058	64961059	11019	hg38	N/A	enh96521	N/A	Enhatls54546	enhancer	E5571	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.06277	0.97657		RAB15	chr14	64945813	64972935	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2527
enhrx-167400	chr9	116113659	116113660	113351379	113351380	11020	hg38	N/A	N/A	N/A	Enhatls179152	enhancer	E5572	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17926	0.97657		BSPRY	chr9	113349540	113371222	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4667
enhrx-23737	chr10	112168152	112168153	110408394	110408395	11021	hg38	N/A	enh1501	fant36997	Enhatls26055	enhancer	E5573	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29873	0.97657		DUSP5	chr10	110497906	110511533	89428	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6172
enhrx-92155	chr2	75903249	75903250	75676123	75676124	11022	hg38	N/A	enh99683	N/A	Enhatls98739	enhancer	E5574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23045	0.97657		MRPL19	chr2	75646782	75690851	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4081
enhrx-92155	chr2	75903249	75903250	75676123	75676124	11023	hg38	N/A	enh99683	N/A	Enhatls98739	enhancer	E5574	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23045	0.97657		GCFC2	chr2	75662704	75710985	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4081
enhrx-118316	chr3	124232197	124232198	124513350	124513351	11024	hg38	N/A	enh35845	N/A	Enhatls126597	enhancer	E5575	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25165	0.97672		KALRN	chr3	124033368	124726325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6445
enhrx-165772	chr9	89255203	89255204	86640288	86640289	11025	hg38	N/A	enh78719	N/A	Enhatls177399	enhancer	E5576	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15628	0.97672		TUT7	chr9	86287732	86354454	281097	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3039
enhrx-161645	chr8	128813106	128813107	127800860	127800861	11026	hg38	N/A	enh10528	N/A	Enhatls172652	enhancer	E5577	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19126	0.97673		MYC	chr8	127735433	127742951	56792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5436
enhrx-157972	chr8	33102771	33102772	33245253	33245254	11027	hg38	N/A	enh40894	N/A	Enhatls168777	enhancer	E5578	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083851	0.97673		FUT10	chr8	33370823	33473146	123507	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1763
enhrx-19032	chr10	27926724	27926725	27637795	27637796	11028	hg38	N/A	enh96052	N/A	Enhatls20793	enhancer	E5579	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17061	0.97673		MKX	chr10	27672873	27746060	33048	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1467
enhrx-131699	chr5	39755613	39755614	39755511	39755512	11029	hg38	N/A	enh37762	N/A	Enhatls140776	enhancer	E5580	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15069	0.97673		DAB2	chr5	39371674	39462300	291204	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1490
enhrx-24963	chr10	129993256	129993257	128194992	128194993	11030	hg38	N/A	N/A	N/A	Enhatls27324	enhancer	E5581	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19735	0.97685		MKI67	chr10	128096658	128126423	67609	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7398
enhrx-59394	chr15	96752863	96752864	96209634	96209635	11031	hg38	N/A	enh52163	N/A	Enhatls63958	enhancer	E5582	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.047707	0.97707		NR2F2	chr15	96325937	96340263	113792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6096
enhrx-88306	chr2	8633516	8633517	8493386	8493387	11032	hg38	N/A	enh5278	N/A	Enhatls94581	enhancer	E5583	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28276	0.97712		ID2	chr2	8678844	8684461	177638	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	232
enhrx-39885	chr12	65809901	65809902	65416121	65416122	11033	hg38	N/A	enh57607	N/A	Enhatls43117	enhancer	E5584	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11527	0.97756		MSRB3	chr12	65278642	65491430	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5195
enhrx-167446	chr9	116530162	116530163	113767882	113767883	11034	hg38	N/A	N/A	N/A	Enhatls179208	enhancer	E5585	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27681	0.97756		ZNF618	chr9	113876281	114056593	106017	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4713
enhrx-56567	chr15	61325289	61325290	61033090	61033091	11035	hg38	N/A	enh31429	N/A	Enhatls60862	enhancer	E5586	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19797	0.97772		RORA	chr15	60488283	61229302	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3269
enhrx-80598	chr19	7463814	7463815	7398928	7398929	11036	hg38	N/A	enh4995	N/A	Enhatls86459	enhancer	E5587	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2333	0.97772		ARHGEF18	chr19	7348936	7472485	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1568
enhrx-176152	chrX	128461529	128461530	129327552	129327553	11037	hg38	N/A	N/A	N/A	Enhatls188356	enhancer	E5588	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23592	0.97782		SMARCA1	chrX	129446504	129523500	89157	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5869
enhrx-159804	chr8	81504818	81504819	80592583	80592584	11038	hg38	N/A	enh46599	N/A	Enhatls170705	enhancer	E5589	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050848	0.97782		ZNF704	chr8	80628450	80874781	34797	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3595
enhrx-43551	chr12	123326169	123326170	122841622	122841623	11039	hg38	N/A	enh15072	N/A	Enhatls47007	enhancer	E5590	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08028	0.97783		HIP1R	chr12	122835456	122862961	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8861
enhrx-109318	chr22	27512507	27512508	27116545	27116546	11040	hg38	N/A	enh35009	N/A	Enhatls116986	enhancer	E5591	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.3832	0.97783		CRYBA4	chr22	26621962	26630669	485496	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1149
enhrx-91414	chr2	66428523	66428524	66201391	66201392	11041	hg38	N/A	enh96903	N/A	Enhatls97957	enhancer	E5592	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27256	0.97788		MEIS1	chr2	66435124	66573869	231662	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3340
enhrx-100976	chr2	237895290	237895291	236986647	236986648	11042	hg38	N/A	enh34428	N/A	Enhatls108013	enhancer	E5593	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16326	0.97828		COPS8	chr2	237085881	237100474	97265	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12902
enhrx-107001	chr21	36250992	36250993	34878695	34878696	11043	hg38	N/A	enh6636	N/A	Enhatls114409	enhancer	E5594	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2056	0.9783		RUNX1	chr21	34787800	36004667	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	884
enhrx-145135	chr6	131555417	131555418	131234277	131234278	11044	hg38	N/A	N/A	N/A	Enhatls155091	enhancer	E5595	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1219	0.97848		AKAP7	chr6	131135466	131283535	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6723
enhrx-77941	chr18	45425191	45425192	47898820	47898821	11045	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	E5596	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12645	0.97848		SMAD2	chr18	47808956	47931146	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1959
enhrx-36144	chr12	13376346	13376347	13223412	13223413	11046	hg38	N/A	enh14550	fant41064	Enhatls39195	enhancer	E5597	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20058	0.97857		EMP1	chr12	13196722	13219941	3264	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1454
enhrx-78329	chr18	55902398	55902399	58235166	58235167	11047	hg38	N/A	enh17738	N/A	Enhatls84032	enhancer	E5598	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16482	0.97857		NEDD4L	chr18	58044225	58401540	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2347
enhrx-155795	chr7	151249648	151249649	151552562	151552563	11048	hg38	N/A	enh24646	N/A	Enhatls166458	enhancer	E5599	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12572	0.97863		PRKAG2	chr7	151556123	151877214	35	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8607
enhrx-57188	chr15	67371988	67371989	67079650	67079651	11049	hg38	N/A	enh3672	N/A	Enhatls61525	enhancer	E5600	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26553	0.97863		SMAD3	chr15	67063762	67195173	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3890
enhrx-157846	chr8	29144478	29144479	29286961	29286962	11050	hg38	N/A	enh24883	N/A	Enhatls168624	enhancer	E5601	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28118	0.97863		KIF13B	chr8	29067277	29263097	17932	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1637
enhrx-160905	chr8	108153130	108153131	107140902	107140903	11051	hg38	N/A	enh25216	N/A	Enhatls171859	enhancer	E5602	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10477	0.97884		ANGPT1	chr8	107249481	107498055	99215	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4696
enhrx-72432	chr17	47673907	47673908	49596545	49596546	11052	hg38	N/A	enh65047	N/A	Enhatls77746	enhancer	E5603	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1856	0.97886		SPOP	chr17	49598883	49678163	531	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5701
enhrx-107274	chr21	40705725	40705726	39333799	39333800	11053	hg38	N/A	enh6666	N/A	Enhatls114718	enhancer	E5604	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19637	0.97887		HMGN1	chr21	39342314	39349647	1	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1157
enhrx-18138	chr10	12513369	12513370	12471370	12471371	11054	hg38	N/A	enh27805	N/A	Enhatls19826	enhancer	E5605	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20436	0.97887		CAMK1D	chr10	12349546	12835545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	573
enhrx-157421	chr8	23448773	23448774	23591260	23591261	11055	hg38	N/A	N/A	N/A	Enhatls168181	enhancer	E5606	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23302	0.97906		SLC25A37	chr8	23528955	23575463	5080	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1212
enhrx-170886	chrX	13506374	13506375	13488255	13488256	11056	hg38	N/A	enh42414	N/A	Enhatls182863	enhancer	E5607	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16778	0.97924		EGFL6	chrX	13569600	13633575	77645	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	603
enhrx-4844	chr1	43409111	43409112	42943440	42943441	11057	hg38	N/A	N/A	N/A	Enhatls5313	enhancer	E5608	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28063	0.97924		SLC2A1	chr1	42925352	42958868	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4843
enhrx-133054	chr5	72926448	72926449	73630623	73630624	11058	hg38	N/A	enh55322	N/A	Enhatls142170	enhancer	E5609	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20149	0.97936		ARHGEF28	chr5	73626157	73941993	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2845
enhrx-147036	chr6	168818132	168818133	168417452	168417453	11059	hg38	N/A	enh66325	N/A	Enhatls157160	enhancer	E5610	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096458	0.9794		SMOC2	chr6	168441150	168667994	20636	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8624
enhrx-19337	chr10	35150671	35150672	34861743	34861744	11060	hg38	N/A	enh47382	N/A	Enhatls21133	enhancer	E5611	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11828	0.9794		PARD3	chr10	34109559	34815325	41953	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1772
enhrx-153520	chr7	116342352	116342353	116702298	116702299	11061	hg38	N/A	N/A	N/A	Enhatls164051	enhancer	E5612	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16934	0.9794		MET	chr7	116672195	116798377	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6332
enhrx-154962	chr7	140676008	140676009	140976208	140976209	11062	hg38	N/A	enh24593	N/A	Enhatls165591	enhancer	E5613	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23449	0.9794		MRPS33	chr7	141002609	141015228	22575	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7774
enhrx-95360	chr2	137427209	137427210	136669639	136669640	11063	hg38	N/A	N/A	N/A	Enhatls102100	enhancer	E5614	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086312	0.97975		THSD7B	chr2	136765544	137677718	12102	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7286
enhrx-lit83	chr11	62328513	62328514	62561041	62561042	11064	hg38					enhancer	E5615	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.035464	0.97975							|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	
enhrx-21513	chr10	80853821	80853822	79094064	79094065	11065	hg38	N/A	enh1378	N/A	Enhatls23676	enhancer	E5616	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.141	0.97976		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3948
enhrx-91276	chr2	62534244	62534245	62307109	62307110	11066	hg38	N/A	enh18593	N/A	Enhatls97795	enhancer	E5617	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23848	0.97976		B3GNT2	chr2	62196114	62224731	80339	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3202
enhrx-44915	chr13	27614248	27614249	27040111	27040112	11067	hg38	N/A	enh2729	N/A	Enhatls48454	enhancer	E5618	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.086917	0.97976		USP12	chr13	27066155	27171811	18678	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	537
enhrx-77414	chr18	30192788	30192789	32612825	32612826	11068	hg38	N/A	enh96797	N/A	Enhatls83070	enhancer	E5619	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.44649	0.97983		KLHL14	chr18	32672672	32773023	57781	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1432
enhrx-27534	chr11	27486117	27486118	27464570	27464571	11069	hg38	N/A	enh13854	N/A	Enhatls29986	enhancer	E5620	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10914	0.98029		LGR4	chr11	27365960	27472790	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2203
enhrx-73859	chr17	64948421	64948422	66952305	66952306	11070	hg38	N/A	enh17319	fant53434	Enhatls79296	enhancer	E5621	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12662	0.98029		CACNG4	chr17	66964706	67033398	12184	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7128
enhrx-132237	chr5	55711479	55711480	56415652	56415653	11071	hg38	N/A	enh8457	fant18557	Enhatls141322	enhancer	E5622	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12591	0.98029		ANKRD55	chr5	56099679	56233330	182028	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2028
enhrx-100071	chr2	224561570	224561571	223696853	223696854	11072	hg38	N/A	enh34322	N/A	Enhatls107064	enhancer	E5623	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14247	0.98036		AP1S3	chr2	223751685	223838027	52067	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11997
enhrx-161686	chr8	130997922	130997923	129985676	129985677	11073	hg38	N/A	enh10552	N/A	Enhatls172706	enhancer	E5624	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.071086	0.98036		CYRIB	chr8	129839592	130017504	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5477
enhrx-118367	chr3	124665326	124665327	124946482	124946483	11074	hg38	N/A	N/A	N/A	Enhatls126656	enhancer	E5625	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1765	0.98036		MUC13	chr3	124905441	124934751	5006	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6496
enhrx-149431	chr7	43804735	43804736	43765136	43765137	11075	hg38	N/A	enh91770	N/A	Enhatls159723	enhancer	E5626	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17421	0.98047		BLVRA	chr7	43758679	43807342	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2243
enhrx-145960	chr6	149482272	149482273	149161136	149161137	11076	hg38	N/A	enh23765	N/A	Enhatls156016	enhancer	E5627	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17028	0.98057		TAB2	chr6	149218640	149411613	54842	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7548
enhrx-50285	chr14	61835280	61835281	61368562	61368563	11077	hg38	N/A	enh15655	N/A	Enhatls54243	enhancer	E5628	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13257	0.98097		PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2242
enhrx-166233	chr9	97629695	97629696	94867413	94867414	11078	hg38	N/A	enh10843	fant32880	Enhatls177916	enhancer	E5629	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12699	0.98121		AOPEP	chr9	94726698	95087159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3500
enhrx-49908	chr14	55823851	55823852	55357133	55357134	11079	hg38	N/A	N/A	N/A	Enhatls53851	enhancer	E5630	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2457	0.98129		FBXO34	chr14	55271343	55353611	2	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1865
enhrx-57949	chr15	75956718	75956719	75664377	75664378	11080	hg38	N/A	enh16332	N/A	Enhatls62343	enhancer	E5631	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1038	0.98129		SNX33	chr15	75647911	75662301	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4651
enhrx-64785	chr16	67597958	67597959	67564055	67564056	11081	hg38	N/A	enh4093	N/A	Enhatls69540	enhancer	E5632	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25386	0.98138		CTCF	chr16	67562466	67639177	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5080
enhrx-134555	chr5	111815314	111815315	112479617	112479618	11082	hg38	N/A	enh22499	N/A	Enhatls143725	enhancer	E5633	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049611	0.98142		EPB41L4A	chr5	112162618	112419277	54892	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4346
enhrx-147036	chr6	168739607	168739608	168338927	168338928	11083	hg38	N/A	N/A	N/A	Enhatls157160	enhancer	E5634	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21465	0.98173		DACT2	chr6	168292829	168319777	16499	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8624
enhrx-156594	chr8	8227816	8227817	8370300	8370301	11084	hg38	N/A	enh10141	N/A	Enhatls167279	enhancer	E5635	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14902	0.98173		PRAG1	chr8	8317735	8386439	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	385
enhrx-6901	chr1	71340668	71340669	70874985	70874986	11085	hg38	N/A	enh95859	N/A	Enhatls7509	enhancer	E5636	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16774	0.98173		PTGER3	chr1	70852352	71047816	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6900
enhrx-165776	chr9	89734489	89734490	87119574	87119575	11086	hg38	N/A	enh63896	N/A	Enhatls177408	enhancer	E5637	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13464	0.98187		GAS1	chr9	86944361	86947506	165925	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3043
enhrx-54441	chr15	39160719	39160720	38868518	38868519	11087	hg38	N/A	enh16050	N/A	Enhatls58634	enhancer	E5638	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10299	0.98189		RASGRP1	chr15	38488102	38565575	293690	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1143
enhrx-133315	chr5	76606794	76606795	77310969	77310970	11088	hg38	N/A	N/A	N/A	Enhatls142435	enhancer	E5639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16064	0.98191		PDE8B	chr5	77086731	77427124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-133315	chr5	76606794	76606795	77310969	77310970	11089	hg38	N/A	N/A	N/A	Enhatls142435	enhancer	E5639	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16064	0.98191		PDE8B	chr5	77210448	77428256	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3106
enhrx-46998	chr13	93067355	93067356	92415102	92415103	11090	hg38	N/A	N/A	N/A	Enhatls50751	enhancer	E5640	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12382	0.98209		GPC5	chr13	91398620	92873682	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2620
enhrx-42190	chr12	110191971	110191972	109754166	109754167	11091	hg38	N/A	enh92416	N/A	Enhatls45578	enhancer	E5641	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21793	0.98209		FAM222A	chr12	109713824	109770495	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7500
enhrx-171960	chrX	39473754	39473755	39614500	39614501	11092	hg38	N/A	enh89379	fant62255	Enhatls184001	enhancer	E5642	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17396	0.9821		BCOR	chrX	40049814	40177329	435040	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1677
enhrx-156714	chr8	11588332	11588333	11730823	11730824	11093	hg38	N/A	enh10169	N/A	Enhatls167414	enhancer	E5643	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31528	0.9821		GATA4	chr8	11676958	11760002	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	505
enhrx-102490	chr20	14826329	14826330	14845683	14845684	11094	hg38	N/A	enh57802	N/A	Enhatls109587	enhancer	E5644	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.0045454	0.98224		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	918
enhrx-84608	chr19	39938471	39938472	39447831	39447832	11095	hg38	N/A	enh5129	N/A	Enhatls90691	enhancer	E5645	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15567	0.98228		SUPT5H	chr19	39436155	39476670	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5578
enhrx-89171	chr2	26235267	26235268	26012398	26012399	11096	hg38	N/A	enh18363	N/A	Enhatls95529	enhancer	E5646	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.11942	0.98264		RAB10	chr2	26034083	26137454	17532	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1097
enhrx-20393	chr10	62233578	62233579	60473820	60473821	11097	hg38	N/A	enh28135	N/A	Enhatls22465	enhancer	E5647	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30302	0.98267		ANK3	chr10	60026297	60733490	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2828
enhrx-139236	chr6	22881472	22881473	22881243	22881244	11098	hg38	N/A	enh38915	N/A	Enhatls148860	enhancer	E5648	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12994	0.98268		HDGFL1	chr6	22569565	22571666	299879	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	824
enhrx-20441	chr10	63950432	63950433	62190673	62190674	11099	hg38	N/A	enh47400	N/A	Enhatls22525	enhancer	E5649	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26179	0.98288		RTKN2	chr10	62183034	62268844	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2876
enhrx-163294	chr9	14251188	14251189	14251189	14251190	11100	hg38	N/A	enh25472	N/A	Enhatls174373	enhancer	E5650	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29873	0.98315		NFIB	chr9	14081842	14398983	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	561
enhrx-133685	chr5	82788345	82788346	83492526	83492527	11101	hg38	N/A	N/A	N/A	Enhatls142816	enhancer	E5651	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25301	0.98325		VCAN	chr5	83471673	83582303	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3476
enhrx-127581	chr4	112881515	112881516	111960359	111960360	11102	hg38	N/A	enh54928	fant16605	Enhatls136447	enhancer	E5652	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17342	0.98327		FAM241A	chr4	112145453	112195256	184999	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5125
enhrx-176819	chrX	141982547	141982548	142894761	142894762	11103	hg38	N/A	N/A	N/A	Enhatls189059	enhancer	E5653	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.050898	0.98327		SPANXN4	chrX	143025927	143034702	94749	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6536
enhrx-7245	chr1	79616902	79616903	79151217	79151218	11104	hg38	N/A	enh79093	N/A	Enhatls7860	enhancer	E5654	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.038441	0.98327		ADGRL4	chr1	78889763	79282124	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7244
enhrx-149323	chr7	39773853	39773854	39734254	39734255	11105	hg38	N/A	enh9756	N/A	Enhatls159596	enhancer	E5655	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2287	0.98327		RALA	chr7	39623571	39708120	25922	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2135
enhrx-113055	chr3	24000978	24000979	23959487	23959488	11106	hg38	N/A	enh86459	N/A	Enhatls120967	enhancer	E5656	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083359	0.98336		NR1D2	chr3	23945285	23980617	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1184
enhrx-106686	chr21	32608733	32608734	31236417	31236418	11107	hg38	N/A	enh45198	N/A	Enhatls114071	enhancer	E5657	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17114	0.98364		TIAM1	chr21	31118415	31558977	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	569
enhrx-137318	chr5	162999064	162999065	163572058	163572059	11108	hg38	N/A	enh38597	N/A	Enhatls146744	enhancer	E5658	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23809	0.98372		MAT2B	chr5	163503113	163519558	47307	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7109
enhrx-32310	chr11	94578978	94578979	94845813	94845814	11109	hg38	N/A	enh62187	N/A	Enhatls35084	enhancer	E5659	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16017	0.9839		AMOTL1	chr11	94706430	94876748	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6979
enhrx-27513	chr11	27195681	27195682	27174134	27174135	11110	hg38	N/A	enh58339	N/A	Enhatls29962	enhancer	E5660	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14619	0.98405		BBOX1	chr11	27040724	27127809	41714	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2182
enhrx-17195	chr1	242402888	242402889	242239586	242239587	11111	hg38	N/A	enh95997	N/A	Enhatls18814	enhancer	E5661	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16975	0.98405		PLD5	chr1	242082985	242524697	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	17194
enhrx-167083	chr9	112968683	112968684	110206403	110206404	11112	hg38	N/A	N/A	N/A	Enhatls178832	enhancer	E5662	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33662	0.98407		C9orf152	chr9	110199560	110208159	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4350
enhrx-65584	chr16	74287772	74287773	74253873	74253874	11113	hg38	N/A	N/A	N/A	Enhatls70377	enhancer	E5663	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16635	0.98422		PSMD7	chr16	74296813	74306288	22144	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5879
enhrx-46038	chr13	48733283	48733284	48159147	48159148	11114	hg38	N/A	enh15309	N/A	Enhatls49696	enhancer	E5664	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16791	0.98426		MED4	chr13	48075723	48095131	61040	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1660
enhrx-68276	chr17	9981042	9981043	10077725	10077726	11115	hg38	N/A	enh16995	N/A	Enhatls73280	enhancer	E5665	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0077915	0.98426		GAS7	chr17	9910605	10198606	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1545
enhrx-6648	chr1	66854740	66854741	66389057	66389058	11116	hg38	N/A	N/A	fant1913	Enhatls7243	enhancer	E5666	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16551	0.98426		PDE4B	chr1	65792513	66374579	14459	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6647
enhrx-106331	chr21	18500817	18500818	17128499	17128500	11117	hg38	N/A	enh97174	N/A	Enhatls113689	enhancer	E5667	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15596	0.98443		CXADR	chr21	17513042	17593579	381706	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	214
enhrx-76965	chr18	20843657	20843658	23263693	23263694	11118	hg38	N/A	N/A	N/A	Enhatls82585	enhancer	E5668	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14047	0.98443		CABLES1	chr18	23134563	23260470	7	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	983
enhrx-31830	chr11	84848835	84848836	85137791	85137792	11119	hg38	N/A	enh96238	N/A	Enhatls34584	enhancer	E5669	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15298	0.98444		DLG2	chr11	83455011	85628335	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6499
enhrx-14029	chr1	200283647	200283648	200314519	200314520	11120	hg38	N/A	enh27416	N/A	Enhatls15457	enhancer	E5670	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20174	0.98449		ZNF281	chr1	200404939	200410056	81534	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	14028
enhrx-162979	chr9	4828947	4828948	4828947	4828948	11121	hg38	N/A	enh89298	N/A	Enhatls174054	enhancer	E5671	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23493	0.98456		RCL1	chr9	4792943	4861075	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	246
enhrx-66974	chr17	2015271	2015272	2111977	2111978	11122	hg38	N/A	enh32048	N/A	Enhatls71921	enhancer	E5672	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.035147	0.98456		SMG6	chr17	2059842	2303785	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	243
enhrx-27615	chr11	31268332	31268333	31246785	31246786	11123	hg38	N/A	N/A	N/A	Enhatls30065	enhancer	E5673	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19655	0.98469		DCDC1	chr11	30863602	31369774	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2284
enhrx-123225	chr4	6697672	6697673	6695945	6695946	11124	hg38	N/A	N/A	N/A	Enhatls131858	enhancer	E5674	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29107	0.9847		S100P	chr4	6693877	6697170	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	769
enhrx-117130	chr3	102390079	102390080	102671235	102671236	11125	hg38	N/A	enh54272	N/A	Enhatls125348	enhancer	E5675	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		-0.015094	0.98476		ZPLD1	chr3	102099243	102479841	190441	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5259
enhrx-22514	chr10	97273211	97273212	95513454	95513455	11126	hg38	N/A	enh28378	N/A	Enhatls24757	enhancer	E5676	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20179	0.98485		SORBS1	chr10	95311770	95561414	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4949
enhrx-96043	chr2	159363949	159363950	158507437	158507438	11127	hg38	N/A	enh33859	N/A	Enhatls102813	enhancer	E5677	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.096482	0.98485		PKP4	chr2	158456951	158682879	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7969
enhrx-50589	chr14	65562349	65562350	65095631	65095632	11128	hg38	N/A	enh3284	N/A	Enhatls54566	enhancer	E5678	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26334	0.98503		MAX	chr14	65006173	65102695	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2546
enhrx-109528	chr22	30191817	30191818	29795828	29795829	11129	hg38	N/A	enh110004	N/A	Enhatls117205	enhancer	E5679	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23906	0.98503		ASCC2	chr22	29788608	29838304	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1359
enhrx-128114	chr4	124229985	124229986	123308830	123308831	11130	hg38	N/A	N/A	N/A	Enhatls136988	enhancer	E5680	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23528	0.98503		AFG2A	chr4	122923069	123319433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5658
enhrx-116341	chr3	67567160	67567161	67516736	67516737	11131	hg38	N/A	enh70649	N/A	Enhatls124501	enhancer	E5681	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23117	0.98515		SUCLG2	chr3	67360459	67654612	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4470
enhrx-8267	chr1	100536101	100536102	100070545	100070546	11132	hg38	N/A	N/A	N/A	Enhatls8951	enhancer	E5682	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13385	0.98515		MFSD14A	chr1	100038094	100083377	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8266
enhrx-45302	chr13	34189823	34189824	33615686	33615687	11133	hg38	N/A	enh15223	N/A	Enhatls48899	enhancer	E5683	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24185	0.98557		RFC3	chr13	33818068	33966558	201809	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	924
enhrx-66936	chr17	1673612	1673613	1770318	1770319	11134	hg38	N/A	N/A	N/A	Enhatls71876	enhancer	E5684	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14542	0.98557		SERPINF1	chr17	1762028	1777565	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	205
enhrx-16731	chr1	235575366	235575367	235412051	235412052	11135	hg38	N/A	N/A	N/A	Enhatls18335	enhancer	E5685	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12413	0.98563		TBCE	chr1	235367359	235452443	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	16730
enhrx-24203	chr10	118667321	118667322	116907810	116907811	11136	hg38	N/A	N/A	N/A	Enhatls26557	enhancer	E5686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14869	0.9859		ENO4	chr10	116849498	116911788	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6638
enhrx-24203	chr10	118667321	118667322	116907810	116907811	11137	hg38	N/A	N/A	N/A	Enhatls26557	enhancer	E5686	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14869	0.9859		SHTN1	chr10	116881476	117126586	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6638
enhrx-41545	chr12	102897003	102897004	102503225	102503226	11138	hg38	N/A	enh86946	N/A	Enhatls44890	enhancer	E5687	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.072639	0.98595		IGF1	chr12	102395873	102481744	18184	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6855
enhrx-122677	chr4	1556806	1556807	1555079	1555080	11139	hg38	N/A	enh77200	N/A	N/A	enhancer	E5688	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.38531	0.98607		FAM53A	chr4	1617914	1684313	57581	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	221
enhrx-8099	chr1	95485028	95485029	95019472	95019473	11140	hg38	N/A	enh26980	N/A	Enhatls8775	enhancer	E5689	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28727	0.98614		ALG14	chr1	94974404	95072951	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8098
enhrx-23711	chr10	111725439	111725440	109965681	109965682	11141	hg38	N/A	enh28441	N/A	Enhatls26026	enhancer	E5690	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13924	0.98624		ADD3	chr10	110005803	110135565	33587	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6146
enhrx-157685	chr8	27540833	27540834	27683316	27683317	11142	hg38	N/A	enh24871	N/A	Enhatls168450	enhancer	E5691	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16535	0.98633		SCARA3	chr8	27633867	27676776	4753	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1476
enhrx-45834	chr13	45334259	45334260	44760123	44760124	11143	hg38	N/A	enh15278	N/A	Enhatls49470	enhancer	E5692	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089397	0.98644		NUFIP1	chr13	44939248	44989471	175007	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1456
enhrx-2625	chr1	22799284	22799285	22472791	22472792	11144	hg38	N/A	enh64005	N/A	Enhatls2914	enhancer	E5693	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13637	0.98666		ZBTB40	chr1	22428837	22531157	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2624
enhrx-157997	chr8	34124729	34124730	34267211	34267212	11145	hg38	N/A	enh102132	N/A	Enhatls168803	enhancer	E5694	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33221	0.98669		DUSP26	chr8	33591329	33600023	665125	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1788
enhrx-47575	chr13	108956717	108956718	108304369	108304370	11146	hg38	N/A	N/A	N/A	Enhatls51372	enhancer	E5695	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.069347	0.98682		TNFSF13B	chr13	108269628	108308484	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3197
enhrx-144089	chr6	108979553	108979554	108658350	108658351	11147	hg38	N/A	enh109059	N/A	Enhatls153975	enhancer	E5696	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14265	0.98702		FOXO3	chr6	108559834	108684774	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5677
enhrx-113083	chr3	25626269	25626270	25584778	25584779	11148	hg38	N/A	enh20431	N/A	Enhatls121002	enhancer	E5697	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.089453	0.98705		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1212
enhrx-89402	chr2	27516108	27516109	27293240	27293241	11149	hg38	N/A	enh33153	N/A	Enhatls95754	enhancer	E5698	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17362	0.98705		TRIM54	chr2	27282428	27307439	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1328
enhrx-150361	chr7	70217870	70217871	70752884	70752885	11150	hg38	N/A	enh46403	N/A	Enhatls160737	enhancer	E5699	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26984	0.98737		AUTS2	chr7	69598295	70793506	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3173
enhrx-94660	chr2	123297700	123297701	122540124	122540125	11151	hg38	N/A	N/A	N/A	Enhatls101361	enhancer	E5700	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21764	0.98737		TSN	chr2	121737102	121767853	765321	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6586
enhrx-149628	chr7	44815963	44815964	44776364	44776365	11152	hg38	N/A	enh98008	N/A	Enhatls159934	enhancer	E5701	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28566	0.98737		ZMIZ2	chr7	44748580	44769881	4406	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2440
enhrx-32511	chr11	102322403	102322404	102451672	102451673	11153	hg38	N/A	N/A	fant39715	Enhatls35300	enhancer	E5702	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14712	0.98759		TMEM123	chr11	102396331	102452839	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7180
enhrx-175993	chrX	121310647	121310648	122176794	122176795	11154	hg38	N/A	N/A	N/A	Enhatls188197	enhancer	E5703	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22271	0.98765		GRIA3	chrX	123184152	123490915	989576	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5710
enhrx-144001	chr6	107149578	107149579	106701703	106701704	11155	hg38	N/A	enh9282	N/A	Enhatls153881	enhancer	E5704	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.0074273	0.98765		QRSL1	chr6	106629577	106668417	30674	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5589
enhrx-165110	chr9	73089554	73089555	70474638	70474639	11156	hg38	N/A	enh41917	N/A	Enhatls176700	enhancer	E5705	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.088283	0.98773		TRPM3	chr9	70529059	71446835	43688	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2377
enhrx-128611	chr4	145671675	145671676	144750523	144750524	11157	hg38	N/A	N/A	N/A	Enhatls137514	enhancer	E5706	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.073377	0.98787		HHIP	chr4	144646155	144745271	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6155
enhrx-123993	chr4	34183077	34183078	34181455	34181456	11158	hg38	N/A	enh36536	N/A	Enhatls132692	enhancer	E5707	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18246	0.9879		ARAP2	chr4	36066003	36244514	1877352	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1537
enhrx-8023	chr1	94534733	94534734	94069177	94069178	11159	hg38	N/A	enh12065	N/A	Enhatls8690	enhancer	E5708	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16567	0.98803		ABCA4	chr1	93992833	94121148	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8022
enhrx-20788	chr10	71093171	71093172	69333415	69333416	11160	hg38	N/A	enh1283	N/A	Enhatls22886	enhancer	E5709	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.049466	0.98804		HK1	chr10	69269983	69401884	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3223
enhrx-130828	chr5	14257154	14257155	14257045	14257046	11161	hg38	N/A	enh22054	N/A	Enhatls139842	enhancer	E5710	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17968	0.98816		TRIO	chr5	14143341	14532128	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	619
enhrx-93025	chr2	97437720	97437721	96771983	96771984	11162	hg38	N/A	enh5715	N/A	Enhatls99634	enhancer	E5711	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23826	0.98821		CNNM4	chr2	96760901	96811874	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4951
enhrx-174714	chrX	96515894	96515895	97260895	97260896	11163	hg38	N/A	enh85766	N/A	Enhatls186887	enhancer	E5712	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17928	0.98821		DIAPH2	chrX	96684711	97604997	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4431
enhrx-45559	chr13	39598171	39598172	39024034	39024035	11164	hg38	N/A	N/A	N/A	Enhatls49160	enhancer	E5713	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23877	0.98821		PROSER1	chr13	39009864	39038089	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1181
enhrx-21070	chr10	73867353	73867354	72107595	72107596	11165	hg38	N/A	enh47408	N/A	Enhatls23191	enhancer	E5714	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18635	0.98825		ASCC1	chr10	72096031	72217134	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3505
enhrx-45314	chr13	35202558	35202559	34628421	34628422	11166	hg38	N/A	enh96406	N/A	Enhatls48914	enhancer	E5715	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34059	0.98833		NBEA	chr13	34942269	35672737	311832	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	936
enhrx-54394	chr15	37526848	37526849	37234647	37234648	11167	hg38	N/A	N/A	N/A	Enhatls58585	enhancer	E5716	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.087676	0.98833		MEIS2	chr15	36889203	37101299	129452	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1096
enhrx-126921	chr4	99898069	99898070	98976918	98976919	11168	hg38	N/A	enh21697	N/A	Enhatls135757	enhancer	E5717	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32327	0.98848		METAP1	chr4	98995720	99062809	16653	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4465
enhrx-144090	chr6	108999293	108999294	108678090	108678091	11169	hg38	N/A	enh59672	N/A	Enhatls153976	enhancer	E5718	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.10419	0.98888		FOXO3	chr6	108559834	108684774	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5678
enhrx-141578	chr6	43672706	43672707	43704969	43704970	11170	hg38	N/A	enh9137	N/A	Enhatls151354	enhancer	E5719	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.35311	0.98902		MRPS18A	chr6	43671201	43687791	9896	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3166
enhrx-117420	chr3	111522121	111522122	111803274	111803275	11171	hg38	N/A	enh20807	N/A	Enhatls125663	enhancer	E5720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21293	0.98902		PLCXD2	chr3	111674675	111846447	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-117420	chr3	111522121	111522122	111803274	111803275	11172	hg38	N/A	enh20807	N/A	Enhatls125663	enhancer	E5720	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21293	0.98902		PHLDB2	chr3	111732496	111976517	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5549
enhrx-85577	chr19	45360133	45360134	44856876	44856877	11173	hg38	N/A	enh18100	N/A	Enhatls91718	enhancer	E5721	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1338	0.9891		NECTIN2	chr19	44846174	44889223	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6547
enhrx-109397	chr22	29491669	29491670	29095681	29095682	11174	hg38	N/A	enh93107	N/A	Enhatls117070	enhancer	E5722	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14948	0.9891		KREMEN1	chr22	29073034	29168333	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1228
enhrx-129659	chr4	174130798	174130799	173209647	173209648	11175	hg38	N/A	enh37368	N/A	Enhatls138607	enhancer	E5723	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13119	0.98911		GALNT7	chr4	173168810	173323967	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7203
enhrx-119908	chr3	148722609	148722610	149004822	149004823	11176	hg38	N/A	N/A	N/A	Enhatls128284	enhancer	E5724	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18739	0.98911		GYG1	chr3	148991407	149031775	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8037
enhrx-82858	chr19	18607861	18607862	18497051	18497052	11177	hg38	N/A	enh5052	N/A	Enhatls88877	enhancer	E5725	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2297	0.98915		ELL	chr19	18442662	18522070	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3828
enhrx-88192	chr2	3347083	3347084	3343312	3343313	11178	hg38	N/A	enh44681	N/A	Enhatls94436	enhancer	E5726	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20315	0.98921		EIPR1	chr2	3188924	3377830	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	118
enhrx-58803	chr15	86422294	86422295	85879063	85879064	11179	hg38	N/A	enh44182	N/A	Enhatls63327	enhancer	E5727	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19244	0.98921		KLHL25	chr15	85759325	85794925	82030	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5505
enhrx-55939	chr15	51497697	51497698	51205500	51205501	11180	hg38	N/A	enh31378	N/A	Enhatls60186	enhancer	E5728	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14759	0.98931		CYP19A1	chr15	51208056	51338601	1910	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2641
enhrx-137082	chr5	156812254	156812255	157385246	157385247	11181	hg38	N/A	enh46000	N/A	Enhatls146485	enhancer	E5729	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24911	0.98939		CYFIP2	chr5	157266078	157395595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6873
enhrx-77945	chr18	45883683	45883684	48357312	48357313	11182	hg38	N/A	enh62685	N/A	Enhatls83619	enhancer	E5730	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16219	0.98944		ZBTB7C	chr18	48026671	48410752	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1963
enhrx-26722	chr11	12520767	12520768	12499220	12499221	11183	hg38	N/A	enh13782	N/A	Enhatls29139	enhancer	E5731	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20617	0.98952		PARVA	chr11	12377570	12535356	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1391
enhrx-146535	chr6	159362523	159362524	158941491	158941492	11184	hg38	N/A	enh23835	fant24878	Enhatls156642	enhancer	E5732	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.083209	0.98952		RSPH3	chr6	158972870	159000202	31150	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8123
enhrx-18654	chr10	21482427	21482428	21193498	21193499	11185	hg38	N/A	enh13033	N/A	Enhatls20412	enhancer	E5733	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18895	0.98955		NEBL	chr10	20779972	21174187	15390	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1089
enhrx-49017	chr14	34607194	34607195	34137988	34137989	11186	hg38	N/A	enh15566	N/A	Enhatls52919	enhancer	E5734	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17832	0.98955		EGLN3	chr14	33924226	34222877	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	974
enhrx-135673	chr5	136552824	136552825	137217135	137217136	11187	hg38	N/A	enh38430	N/A	Enhatls144945	enhancer	E5735	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24764	0.98966		SPOCK1	chr5	136975297	137499326	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5464
enhrx-12021	chr1	163228159	163228160	163258369	163258370	11188	hg38	N/A	enh79227	N/A	Enhatls13318	enhancer	E5736	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17583	0.98966		RGS5	chr1	163142298	163321791	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12020
enhrx-15402	chr1	214390286	214390287	214216943	214216944	11189	hg38	N/A	enh12655	N/A	Enhatls16929	enhancer	E5737	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14977	0.9898		SMYD2	chr1	214281158	214337131	59627	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	15401
enhrx-159415	chr8	68492574	68492575	67580339	67580340	11190	hg38	N/A	enh94738	N/A	Enhatls170282	enhancer	E5738	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33959	0.98988		CPA6	chr8	67422037	67746360	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3206
enhrx-2066	chr1	17877671	17877672	17551176	17551177	11191	hg38	N/A	enh26559	N/A	Enhatls2312	enhancer	E5739	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14999	0.98997		ARHGEF10L	chr1	17539697	17697869	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2065
enhrx-126355	chr4	84578604	84578605	83657451	83657452	11192	hg38	N/A	enh21648	N/A	Enhatls135168	enhancer	E5740	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.082682	0.98997		GPAT3	chr4	83535913	83605875	49478	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3899
enhrx-2274	chr1	19725031	19725032	19398537	19398538	11193	hg38	N/A	enh98	N/A	Enhatls2532	enhancer	E5741	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27018	0.99023		CAPZB	chr1	19338774	19485539	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2273
enhrx-3112	chr1	26742872	26742873	26416381	26416382	11194	hg38	N/A	enh11653	N/A	Enhatls3459	enhancer	E5742	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19659	0.99059		LIN28A	chr1	26410816	26429728	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3111
enhrx-157684	chr8	27532866	27532867	27675349	27675350	11195	hg38	N/A	enh63750	N/A	Enhatls168449	enhancer	E5743	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.067951	0.99065		SCARA3	chr8	27633867	27676776	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1475
enhrx-123295	chr4	7974661	7974662	7972934	7972935	11196	hg38	N/A	enh21353	N/A	Enhatls131944	enhancer	E5744	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16839	0.99079		ABLIM2	chr4	7965311	8158832	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	839
enhrx-142168	chr6	53734896	53734897	53870098	53870099	11197	hg38	N/A	enh97852	N/A	Enhatls151988	enhancer	E5745	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23341	0.99079		LRRC1	chr6	53795004	53924125	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3756
enhrx-148793	chr7	30278673	30278674	30239057	30239058	11198	hg38	N/A	enh9713	N/A	Enhatls159019	enhancer	E5746	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26639	0.99079		ZNRF2	chr7	30284596	30367689	40402	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1605
enhrx-113080	chr3	25484151	25484152	25442660	25442661	11199	hg38	N/A	enh115774	N/A	Enhatls120997	enhancer	E5747	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16362	0.99104		RARB	chr3	24687886	25597932	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1209
enhrx-126469	chr4	87140166	87140167	86219013	86219014	11200	hg38	N/A	enh8070	N/A	Enhatls135286	enhancer	E5748	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16037	0.99118		MAPK10	chr4	85990006	86594625	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4013
enhrx-77706	chr18	40524292	40524293	42944327	42944328	11201	hg38	N/A	N/A	N/A	Enhatls83374	enhancer	E5749	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20147	0.99118		RIT2	chr18	42743226	43115691	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1724
enhrx-56225	chr15	55636467	55636468	55344269	55344270	11202	hg38	N/A	enh3598	N/A	Enhatls60486	enhancer	E5750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09254	0.9913		PIGB	chr15	55319221	55355648	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2927
enhrx-56225	chr15	55636467	55636468	55344269	55344270	11203	hg38	N/A	enh3598	N/A	Enhatls60486	enhancer	E5750	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.09254	0.9913		CCPG1	chr15	55340031	55408510	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2927
enhrx-73843	chr17	64372122	64372123	66376004	66376005	11204	hg38	N/A	enh17313	N/A	Enhatls79272	enhancer	E5751	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12136	0.9913		PRKCA	chr17	66302612	66810743	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7112
enhrx-131317	chr5	35313599	35313600	35313497	35313498	11205	hg38	N/A	enh55200	N/A	Enhatls140362	enhancer	E5752	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.3044	0.9913		PRLR	chr5	35048755	35230487	78230	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1108
enhrx-44929	chr13	27893727	27893728	27319590	27319591	11206	hg38	N/A	N/A	N/A	Enhatls48473	enhancer	E5753	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19894	0.99132		RASL11A	chr13	27270829	27275192	39818	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	551
enhrx-47549	chr13	107085497	107085498	106433149	106433150	11207	hg38	N/A	enh108582	N/A	Enhatls51342	enhancer	E5754	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29512	0.99132		EFNB2	chr13	106489744	106535662	54818	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3171
enhrx-77933	chr18	45342440	45342441	47816069	47816070	11208	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	E5755	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16441	0.99138		SMAD2	chr18	47808956	47931146	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1951
enhrx-32125	chr11	91731831	91731832	91998665	91998666	11209	hg38	N/A	N/A	N/A	Enhatls34895	enhancer	E5756	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1447	0.99138		FAT3	chr11	92224817	92896473	156644	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6794
enhrx-60966	chr16	5692271	5692272	5642270	5642271	11210	hg38	N/A	N/A	N/A	Enhatls65542	enhancer	E5757	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.094775	0.99138		RBFOX1	chr16	5239801	7713340	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1261
enhrx-142209	chr6	54564047	54564048	54699249	54699250	11211	hg38	N/A	enh59628	fant22967	Enhatls152030	enhancer	E5758	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26469	0.99158		FAM83B	chr6	54846770	54945099	147444	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3797
enhrx-138688	chr6	6689314	6689315	6689081	6689082	11212	hg38	N/A	enh22960	N/A	Enhatls148271	enhancer	E5759	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.44536	0.99158		LY86	chr6	6588107	6654983	32425	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	276
enhrx-156607	chr8	8960274	8960275	9102764	9102765	11213	hg38	N/A	enh24736	N/A	Enhatls167293	enhancer	E5760	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14661	0.99159		ERI1	chr8	9002843	9116746	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	398
enhrx-174663	chrX	92759236	92759237	93504237	93504238	11214	hg38	N/A	N/A	N/A	Enhatls186833	enhancer	E5761	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26267	0.99159		NAP1L3	chrX	93670929	93673578	134257	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4380
enhrx-147926	chr7	7493766	7493767	7454135	7454136	11215	hg38	N/A	N/A	N/A	Enhatls158082	enhancer	E5762	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28371	0.99173		COL28A1	chr7	7356567	7535873	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	738
enhrx-160236	chr8	95056725	95056726	94044497	94044498	11216	hg38	N/A	enh41248	N/A	Enhatls171158	enhancer	E5763	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25334	0.99173		CDH17	chr8	94127161	94217303	79211	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4027
enhrx-117609	chr3	113255876	113255877	113537029	113537030	11217	hg38	N/A	enh63188	N/A	Enhatls125873	enhancer	E5764	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.18903	0.99173		SIDT1	chr3	113532554	113629575	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5738
enhrx-99395	chr2	215578335	215578336	214713611	214713612	11218	hg38	N/A	N/A	N/A	Enhatls106333	enhancer	E5765	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.077281	0.99205		BARD1	chr2	214725645	214809683	20	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11321
enhrx-77818	chr18	43642884	43642885	46062918	46062919	11219	hg38	N/A	enh17654	N/A	Enhatls83491	enhancer	E5766	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28479	0.99209		PSTPIP2	chr18	45983535	46072260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1836
enhrx-58172	chr15	78667283	78667284	78374941	78374942	11220	hg38	N/A	enh52113	N/A	Enhatls62588	enhancer	E5767	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2652	0.99213		CRABP1	chr15	78340352	78348225	21528	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4874
enhrx-53708	chr15	28051176	28051177	27806030	27806031	11221	hg38	N/A	N/A	N/A	Enhatls57867	enhancer	E5768	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24909	0.99216		OCA2	chr15	27754874	28099315	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	410
enhrx-156409	chr8	3454090	3454091	3596568	3596569	11222	hg38	N/A	N/A	N/A	Enhatls167078	enhancer	E5769	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24418	0.99218		CSMD1	chr8	2935352	4994972	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	200
enhrx-116482	chr3	72677469	72677470	72628318	72628319	11223	hg38	N/A	enh20703	N/A	Enhatls124659	enhancer	E5770	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19669	0.99222		SHQ1	chr3	72749276	72861914	117655	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4611
enhrx-57220	chr15	67709559	67709560	67417221	67417222	11224	hg38	N/A	N/A	N/A	Enhatls61560	enhancer	E5771	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2079	0.99222		IQCH	chr15	67254785	67502260	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3922
enhrx-57517	chr15	72447751	72447752	72155410	72155411	11225	hg38	N/A	enh44154	N/A	Enhatls61884	enhancer	E5772	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23525	0.99222		GRAMD2A	chr15	72159805	72197787	3614	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4219
enhrx-66962	chr17	1899960	1899961	1996666	1996667	11226	hg38	N/A	enh16929	N/A	Enhatls71906	enhancer	E5773	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25499	0.99222		RTN4RL1	chr17	1934676	2025334	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	231
enhrx-160675	chr8	102473175	102473176	101460947	101460948	11227	hg38	N/A	enh25180	N/A	Enhatls171623	enhancer	E5774	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34321	0.99229		GRHL2	chr8	101492438	101669726	25730	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4466
enhrx-165522	chr9	84164951	84164952	81550036	81550037	11228	hg38	N/A	enh73704	N/A	Enhatls177133	enhancer	E5775	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17757	0.99232		TLE1	chr9	81583682	81689547	31263	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2789
enhrx-118638	chr3	128054514	128054515	128335671	128335672	11229	hg38	N/A	enh20910	fant13428	Enhatls126954	enhancer	E5776	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22063	0.99246		EEFSEC	chr3	128153480	128408646	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6767
enhrx-133807	chr5	88325030	88325031	89029213	89029214	11230	hg38	N/A	enh83819	N/A	Enhatls142948	enhancer	E5777	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2352	0.9925		MEF2C	chr5	88717116	88904257	122792	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3598
enhrx-127315	chr4	106887382	106887383	105966225	105966226	11231	hg38	N/A	enh54901	N/A	Enhatls136166	enhancer	E5778	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2717	0.99261		NPNT	chr4	105894774	106004027	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4859
enhrx-31959	chr11	87933511	87933512	88200343	88200344	11232	hg38	N/A	N/A	N/A	Enhatls34726	enhancer	E5779	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.054089	0.99267		RAB38	chr11	88113250	88175443	21813	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6628
enhrx-135836	chr5	137945423	137945424	138609734	138609735	11233	hg38	N/A	N/A	N/A	Enhatls145114	enhancer	E5780	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25209	0.99278		CTNNA1	chr5	138610966	138935034	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5627
enhrx-130983	chr5	17445524	17445525	17445415	17445416	11234	hg38	N/A	enh77562	N/A	N/A	enhancer	E5781	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16735	0.9928		LINC02218	chr5	17444009	17487371	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	774
enhrx-62315	chr16	23521122	23521123	23509801	23509802	11235	hg38	N/A	N/A	N/A	Enhatls66948	enhancer	E5782	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28581	0.99285		GGA2	chr16	23463541	23521995	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2610
enhrx-58151	chr15	78501852	78501853	78209510	78209511	11236	hg38	N/A	enh62503	N/A	Enhatls62567	enhancer	E5783	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32962	0.9929		ACSBG1	chr15	78167467	78245688	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4853
enhrx-88795	chr2	19258926	19258927	19059165	19059166	11237	hg38	N/A	enh18310	N/A	Enhatls95132	enhancer	E5784	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23185	0.99294		OSR1	chr2	19351484	19358623	289491	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	721
enhrx-157849	chr8	29619095	29619096	29761579	29761580	11238	hg38	N/A	enh10219	N/A	Enhatls168635	enhancer	E5785	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15262	0.99314		SARAF	chr8	30063002	30083208	297350	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1640
enhrx-130978	chr5	17306233	17306234	17306124	17306125	11239	hg38	N/A	enh22081	N/A	Enhatls140001	enhancer	E5786	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29282	0.99317		BASP1	chr5	17065597	17276843	26376	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	769
enhrx-99899	chr2	220263747	220263748	219399025	219399026	11240	hg38	N/A	N/A	N/A	Enhatls106884	enhancer	E5787	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13793	0.99319		DNPEP	chr2	219372042	219400022	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11825
enhrx-31486	chr11	76536116	76536117	76825072	76825073	11241	hg38	N/A	enh14115	N/A	Enhatls34227	enhancer	E5788	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14568	0.99319		TSKU	chr11	76782250	76798153	25743	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6155
enhrx-96998	chr2	172654989	172654990	171798479	171798480	11242	hg38	N/A	enh33951	N/A	Enhatls103814	enhancer	E5789	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.15848	0.99328		SLC25A12	chr2	171783404	171894244	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8924
enhrx-21512	chr10	80809280	80809281	79049523	79049524	11243	hg38	N/A	enh13336	N/A	Enhatls23674	enhancer	E5790	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13683	0.99332		ZMIZ1	chr10	79068965	79316519	14964	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3947
enhrx-78175	chr18	52028327	52028328	54501957	54501958	11244	hg38	N/A	enh4847	N/A	Enhatls83864	enhancer	E5791	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.27339	0.99332		DYNAP	chr18	54587756	54599493	78887	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2193
enhrx-159800	chr8	81315662	81315663	80403427	80403428	11245	hg38	N/A	enh25093	N/A	Enhatls170701	enhancer	E5792	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13781	0.99332		ZBTB10	chr8	80485618	80526265	76119	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3591
enhrx-7308	chr1	84486109	84486110	84020426	84020427	11246	hg38	N/A	enh79110	N/A	Enhatls7929	enhancer	E5793	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20596	0.99351		TTLL7	chr1	83865023	83999150	19093	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7307
enhrx-106298	chr21	16904438	16904439	15532119	15532120	11247	hg38	N/A	N/A	N/A	Enhatls113652	enhancer	E5794	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16757	0.99363		USP25	chr21	15729981	15880064	182164	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	181
enhrx-44915	chr13	27597040	27597041	27022903	27022904	11248	hg38	N/A	enh15172	N/A	Enhatls48454	enhancer	E5795	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22325	0.99366		USP12	chr13	27066155	27171811	34818	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	537
enhrx-102490	chr20	14745650	14745651	14765004	14765005	11249	hg38	N/A	enh82208	N/A	Enhatls109587	enhancer	E5796	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13342	0.99372		MACROD2	chr20	13995368	16053197	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	918
enhrx-124078	chr4	38011782	38011783	38010161	38010162	11250	hg38	N/A	enh21439	N/A	Enhatls132779	enhancer	E5797	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24772	0.99372		TBC1D1	chr4	37891083	38139173	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1622
enhrx-29954	chr11	64795246	64795247	65027774	65027775	11251	hg38	N/A	N/A	N/A	Enhatls32525	enhancer	E5799	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19372	0.99372		SNX15	chr11	65027438	65040572	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4623
enhrx-133053	chr5	72908873	72908874	73613048	73613049	11252	hg38	N/A	enh55321	N/A	Enhatls142169	enhancer	E5800	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.14344	0.99413		ARHGEF28	chr5	73626157	73941993	6328	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2844
enhrx-90330	chr2	40699197	40699198	40472057	40472058	11253	hg38	N/A	N/A	N/A	Enhatls96767	enhancer	E5801	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1743	0.9944		SLC8A1	chr2	40097269	40611053	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2256
enhrx-33306	chr11	115228000	115228001	115357281	115357282	11254	hg38	N/A	N/A	N/A	Enhatls36141	enhancer	E5802	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22727	0.99444		CADM1	chr11	115169235	115504957	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7975
enhrx-23960	chr10	115705564	115705565	113945805	113945806	11255	hg38	N/A	enh13525	N/A	Enhatls26304	enhancer	E5803	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19609	0.99458		NHLRC2	chr10	113854660	113917194	25693	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6395
enhrx-88626	chr2	11963074	11963075	11822948	11822949	11256	hg38	N/A	N/A	N/A	Enhatls94942	enhancer	E5804	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19913	0.99467		LPIN1	chr2	11677594	11827409	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	552
enhrx-153424	chr7	112000989	112000990	112360934	112360935	11257	hg38	N/A	N/A	N/A	Enhatls163946	enhancer	E5805	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.37596	0.99472		ZNF277	chr7	112206694	112343934	2	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6236
enhrx-140597	chr6	35133699	35133700	35165922	35165923	11258	hg38	N/A	enh23174	fant22342	Enhatls150305	enhancer	E5806	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26694	0.99477		TCP11	chr6	35118070	35148610	17166	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2185
enhrx-26960	chr11	17261023	17261024	17239476	17239477	11259	hg38	N/A	enh13822	N/A	Enhatls29388	enhancer	E5807	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.081579	0.9948		NUCB2	chr11	17208152	17332211	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1629
enhrx-12288	chr1	168585444	168585445	168616206	168616207	11260	hg38	N/A	enh43075	N/A	Enhatls13611	enhancer	E5808	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28861	0.9948		XCL1	chr1	168576604	168582069	25119	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12287
enhrx-94387	chr2	116251223	116251224	115493647	115493648	11261	hg38	N/A	N/A	N/A	Enhatls101078	enhancer	E5809	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21792	0.99513		DPP10	chr2	114442298	115845780	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6313
enhrx-26874	chr11	15224340	15224341	15202794	15202795	11262	hg38	N/A	N/A	N/A	Enhatls29295	enhancer	E5811	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.215	0.99517		INSC	chr11	15112423	15247208	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1543
enhrx-13791	chr1	195985531	195985532	196016401	196016402	11263	hg38	N/A	N/A	N/A	Enhatls15214	enhancer	E5812	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.16379	0.99517		KCNT2	chr1	196225778	196609225	137624	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	13790
enhrx-12953	chr1	178520658	178520659	178551523	178551524	11264	hg38	N/A	enh92129	N/A	Enhatls14312	enhancer	E5813	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33723	0.99517		TEX35	chr1	178513108	178523431	25980	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12952
enhrx-168160	chr9	128035151	128035152	125272872	125272873	11265	hg38	N/A	enh26003	N/A	Enhatls179988	enhancer	E5814	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.43051	0.99517		GAPVD1	chr9	125261809	125367207	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5427
enhrx-116114	chr3	61993287	61993288	62007613	62007614	11266	hg38	N/A	enh97271	N/A	Enhatls124246	enhancer	E5815	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.051823	0.99517		PTPRG	chr3	61561570	62297609	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4243
enhrx-1024	chr1	9565629	9565630	9505570	9505571	11267	hg38	N/A	N/A	N/A	Enhatls1104	enhancer	E5816	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.08098	0.99546		SLC25A33	chr1	9539464	9585173	12159	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1023
enhrx-102550	chr20	16741293	16741294	16760648	16760649	11268	hg38	N/A	enh19501	N/A	Enhatls109647	enhancer	E5817	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32536	0.9955		OTOR	chr20	16748357	16752164	5037	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	978
enhrx-20988	chr10	73094359	73094360	71334602	71334603	11269	hg38	N/A	enh13287	N/A	Enhatls23105	enhancer	E5818	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.20411	0.99556		SLC29A3	chr10	71319258	71363385	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3423
enhrx-50374	chr14	64363183	64363184	63896465	63896466	11270	hg38	N/A	enh15675	N/A	Enhatls54339	enhancer	E5819	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22673	0.99559		SYNE2	chr14	63761898	64226433	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2331
enhrx-149363	chr7	41067168	41067169	41027570	41027571	11271	hg38	N/A	enh24129	N/A	Enhatls159637	enhancer	E5820	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24485	0.99559		SUGCT	chr7	40135004	40860763	164549	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2175
enhrx-76597	chr18	12255868	12255869	12255869	12255870	11272	hg38	N/A	enh17573	N/A	Enhatls82197	enhancer	E5821	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19352	0.99559		CIDEA	chr18	12254360	12277595	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	615
enhrx-142560	chr6	70528263	70528264	69818371	69818372	11273	hg38	N/A	enh9194	N/A	Enhatls152404	enhancer	E5822	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.065277	0.99568		LMBRD1	chr6	69672756	69867236	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4148
enhrx-127955	chr4	122641326	122641327	121720171	121720172	11274	hg38	N/A	enh21756	N/A	Enhatls136828	enhancer	E5823	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22861	0.99581		ANXA5	chr4	121667945	121696980	18831	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5499
enhrx-12764	chr1	174934439	174934440	174965302	174965303	11275	hg38	N/A	enh50056	N/A	Enhatls14104	enhancer	E5824	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.41176	0.99581		RABGAP1L	chr1	174159409	174995308	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12763
enhrx-113221	chr3	29543132	29543133	29501641	29501642	11276	hg38	N/A	N/A	N/A	Enhatls121148	enhancer	E5825	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26016	0.99581		RBMS3	chr3	28576174	30010391	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1350
enhrx-100071	chr2	224570078	224570079	223705361	223705362	11277	hg38	N/A	enh34322	N/A	Enhatls107064	enhancer	E5826	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28865	0.99586		AP1S3	chr2	223751685	223838027	44417	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11997
enhrx-164468	chr9	37399667	37399668	37399670	37399671	11278	hg38	N/A	enh10754	N/A	Enhatls175606	enhancer	E5827	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.502	0.99586		GRHPR	chr9	37422695	37436990	19668	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1735
enhrx-119213	chr3	134083677	134083678	134364835	134364836	11279	hg38	N/A	enh65761	fant13565	Enhatls127571	enhancer	E5828	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19222	0.99586		AMOTL2	chr3	134355346	134375479	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7342
enhrx-157576	chr8	25946265	25946266	26088749	26088750	11280	hg38	N/A	N/A	N/A	Enhatls168342	enhancer	E5829	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26559	0.99587		EBF2	chr8	25841724	26045413	38827	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1367
enhrx-116077	chr3	58697811	58697812	58712084	58712085	11281	hg38	N/A	enh45422	N/A	Enhatls124208	enhancer	E5830	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39544	0.99587		CFAP20DC	chr3	58717364	59050084	3219	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4206
enhrx-129535	chr4	169757261	169757262	168836110	168836111	11282	hg38	N/A	enh100290	N/A	Enhatls138471	enhancer	E5831	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34386	0.996		PALLD	chr4	168497051	168928457	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7079
enhrx-8098	chr1	95421553	95421554	94955997	94955998	11283	hg38	N/A	enh12085	N/A	Enhatls8772	enhancer	E5832	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19367	0.99611		ALG14	chr1	94974404	95072951	13091	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8097
enhrx-77530	chr18	33093415	33093416	35513451	35513452	11284	hg38	N/A	enh4781	fant54870	Enhatls83187	enhancer	E5833	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.03079	0.99611		INO80C	chr18	35452229	35497960	15482	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1548
enhrx-99888	chr2	220233580	220233581	219368858	219368859	11285	hg38	N/A	enh19245	N/A	Enhatls106873	enhancer	E5834	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17019	0.99613		DNPEP	chr2	219372042	219400022	190	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	11814
enhrx-46632	chr13	73784466	73784467	73210329	73210330	11286	hg38	N/A	enh15378	N/A	Enhatls50348	enhancer	E5835	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.097905	0.99654		KLF5	chr13	73054975	73077541	130218	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2254
enhrx-88817	chr2	20133489	20133490	19933728	19933729	11287	hg38	N/A	N/A	N/A	Enhatls95153	enhancer	E5836	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21376	0.99665		WDR35	chr2	19910262	19990105	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	743
enhrx-149135	chr7	36305454	36305455	36265845	36265846	11288	hg38	N/A	enh9737	fant26123	Enhatls159399	enhancer	E5837	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23604	0.99672		EEPD1	chr7	36153253	36301538	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1947
enhrx-125549	chr4	71644832	71644833	70779115	70779116	11289	hg38	N/A	N/A	N/A	Enhatls134313	enhancer	E5838	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19229	0.99672		RUFY3	chr4	70704203	70808619	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3093
enhrx-145718	chr6	144066734	144066735	143745597	143745598	11290	hg38	N/A	enh23737	fant24489	Enhatls155763	enhancer	E5839	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23808	0.99676		PHACTR2	chr6	143536844	143831185	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7306
enhrx-116814	chr3	97298451	97298452	97579607	97579608	11291	hg38	N/A	N/A	N/A	Enhatls125003	enhancer	E5840	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.45608	0.997		EPHA6	chr3	96814580	97761532	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4943
enhrx-160420	chr8	98074231	98074232	97062003	97062004	11292	hg38	N/A	enh85146	N/A	Enhatls171354	enhancer	E5841	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.36237	0.99704		CPQ	chr8	96645241	97149654	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4211
enhrx-111103	chr22	43407340	43407341	43011334	43011335	11293	hg38	N/A	enh20239	N/A	Enhatls118890	enhancer	E5842	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.12047	0.99722		PACSIN2	chr22	42869767	43015149	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2934
enhrx-162931	chr9	3732826	3732827	3732826	3732827	11294	hg38	N/A	enh41674	N/A	Enhatls174002	enhancer	E5843	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17635	0.99743		GLIS3	chr9	3824126	4300068	88352	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	198
enhrx-21516	chr10	80989257	80989258	79229500	79229501	11295	hg38	N/A	enh1381	N/A	Enhatls23682	enhancer	E5844	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.090531	0.99743		ZMIZ1	chr10	79068965	79316519	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3951
enhrx-111313	chr22	45501261	45501262	45105380	45105381	11296	hg38	N/A	enh20250	fant61598	Enhatls119112	enhancer	E5845	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23675	0.99753		NUP50	chr22	45163924	45188017	58439	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3144
enhrx-161251	chr8	120763528	120763529	119751288	119751289	11297	hg38	N/A	enh41467	N/A	Enhatls172224	enhancer	E5846	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29769	0.99762		TAF2	chr8	119730773	119832855	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5042
enhrx-31739	chr11	80823999	80824000	81112956	81112957	11298	hg38	N/A	enh96231	N/A	Enhatls34487	enhancer	E5847	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31035	0.99762		FAM181B	chr11	82729939	82733864	1613868	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6408
enhrx-129157	chr4	157692712	157692713	156771560	156771561	11299	hg38	N/A	enh59410	fant17193	Enhatls138081	enhancer	E5848	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13366	0.99762		PDGFC	chr4	156760453	156971799	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6701
enhrx-94062	chr2	111897306	111897307	111139729	111139730	11300	hg38	N/A	enh62832	N/A	Enhatls100734	enhancer	E5849	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29649	0.99763		BCL2L11	chr2	111119377	111168444	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5988
enhrx-73196	chr17	57839320	57839321	59761959	59761960	11301	hg38	N/A	enh4505	N/A	Enhatls78577	enhancer	E5850	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29253	0.998		VMP1	chr17	59707516	59842255	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6465
enhrx-50285	chr14	61822800	61822801	61356082	61356083	11302	hg38	N/A	enh15655	fant46232	Enhatls54243	enhancer	E5851	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.33591	0.998		PRKCH	chr14	61187558	61550976	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2242
enhrx-67032	chr17	2538043	2538044	2634749	2634750	11303	hg38	N/A	N/A	N/A	Enhatls71985	enhancer	E5852	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.1808	0.99817		PAFAH1B1	chr17	2593209	2685615	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	301
enhrx-18728	chr10	22922270	22922271	22633341	22633342	11304	hg38	N/A	enh13049	fant35077	Enhatls20483	enhancer	E5853	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.31868	0.9982		PIP4K2A	chr10	22534853	22714578	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1163
enhrx-137636	chr5	172302964	172302965	172875961	172875962	11305	hg38	N/A	enh22817	N/A	Enhatls147099	enhancer	E5854	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.26267	0.99822		ERGIC1	chr5	172834250	172952683	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7427
enhrx-162832	chr9	995901	995902	995901	995902	11306	hg38	N/A	enh25415	N/A	Enhatls173899	enhancer	E5855	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.3888	0.9983		DMRT3	chr9	976654	991732	354	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	99
enhrx-174714	chrX	96551179	96551180	97296180	97296181	11307	hg38	N/A	N/A	N/A	Enhatls186887	enhancer	E5856	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.21004	0.99837		DIAPH2	chrX	96684711	97604997	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4431
enhrx-109375	chr22	29180231	29180232	28784243	28784244	11308	hg38	N/A	N/A	N/A	Enhatls117047	enhancer	E5857	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.13892	0.99837		CCDC117	chr22	28772673	28789301	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1206
enhrx-64020	chr16	56454385	56454386	56420473	56420474	11309	hg38	N/A	enh4041	N/A	Enhatls68713	enhancer	E5858	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19654	0.99845		AMFR	chr16	56361451	56425545	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4315
enhrx-64939	chr16	68234245	68234246	68200342	68200343	11310	hg38	N/A	enh4104	fant50815	Enhatls69692	enhancer	E5859	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.19948	0.99863		NFATC3	chr16	68085343	68229259	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5234
enhrx-123237	chr4	6959099	6959100	6957372	6957373	11311	hg38	N/A	enh91529	N/A	Enhatls131873	enhancer	E5860	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.34743	0.9989		TBC1D14	chr4	6909241	7033118	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	781
enhrx-146975	chr6	168151869	168151870	167751189	167751190	11312	hg38	N/A	enh23877	N/A	Enhatls157094	enhancer	E5861	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.36373	0.99893		AFDN	chr6	167826892	167972023	73618	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	8563
enhrx-134554	chr5	111674864	111674865	112339167	112339168	11313	hg38	N/A	enh63447	N/A	Enhatls143724	enhancer	E5862	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2608	0.99897		EPB41L4A	chr5	112162618	112419277	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4345
enhrx-111478	chr22	47005367	47005368	46609470	46609471	11314	hg38	N/A	enh6923	N/A	Enhatls119298	enhancer	E5863	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23973	0.99898		GRAMD4	chr22	46576011	46679790	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3309
enhrx-41575	chr12	103766979	103766980	103373201	103373202	11315	hg38	N/A	enh96352	N/A	Enhatls44921	enhancer	E5864	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25962	0.99898		C12orf42	chr12	103301954	103495978	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6885
enhrx-77200	chr18	24197310	24197311	26617346	26617347	11316	hg38	N/A	enh17618	N/A	Enhatls82852	enhancer	E5865	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.24004	0.99901		KCTD1	chr18	26454909	26657401	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1218
enhrx-88801	chr2	19800937	19800938	19601176	19601177	11317	hg38	N/A	N/A	N/A	Enhatls95137	enhancer	E5866	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.30407	0.99901		OSR1	chr2	19351484	19358623	241249	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	727
enhrx-146400	chr6	157159111	157159112	156837977	156837978	11318	hg38	N/A	enh9477	fant24794	Enhatls156483	enhancer	E5867	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28725	0.99929		ARID1B	chr6	156776019	157210779	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7988
enhrx-57628	chr15	73263929	73263930	72971588	72971589	11319	hg38	N/A	enh52085	N/A	Enhatls61995	enhancer	E5868	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.17045	0.99932		NEO1	chr15	73051709	73305205	78016	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4330
enhrx-27196	chr11	18597129	18597130	18575582	18575583	11320	hg38	N/A	enh92286	N/A	Enhatls29630	enhancer	E5869	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.40642	0.99939		UEVLD	chr11	18529608	18588746	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1865
enhrx-24344	chr10	121423758	121423759	119664246	119664247	11321	hg38	N/A	enh1541	N/A	Enhatls26708	enhancer	E5870	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.2643	0.99948		BAG3	chr10	119651379	119677819	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	6779
enhrx-76347	chr18	7032749	7032750	7032750	7032751	11322	hg38	N/A	N/A	N/A	Enhatls81931	enhancer	E5871	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.28178	0.99952		LAMA1	chr18	6941741	7117797	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	365
enhrx-100181	chr2	227348918	227348919	226484202	226484203	11323	hg38	N/A	enh19277	N/A	Enhatls107182	enhancer	E5872	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.3303	0.99956		IRS1	chr2	226731311	226799820	244238	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	12107
enhrx-20302	chr10	60228521	60228522	58468761	58468762	11324	hg38	N/A	enh28107	N/A	Enhatls22361	enhancer	E5873	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39345	0.99957		BICC1	chr10	58512871	58831435	41517	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	2737
enhrx-91815	chr2	71871357	71871358	71644227	71644228	11325	hg38	N/A	enh95010	N/A	Enhatls98383	enhancer	E5874	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32989	0.99957		DYSF	chr2	71453560	71686763	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	3741
enhrx-65496	chr16	71995478	71995479	71961579	71961580	11326	hg38	N/A	enh60628	N/A	Enhatls70288	enhancer	E5875	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.23616	0.99966		PKD1L3	chr16	71929537	72000402	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5791
enhrx-154366	chr7	131827575	131827576	132142816	132142817	11327	hg38	N/A	N/A	N/A	Enhatls164962	enhancer	E5876	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.22648	0.99975		PLXNA4	chr7	132123339	132648688	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	7178
enhrx-19335	chr10	34988135	34988136	34699207	34699208	11328	hg38	N/A	enh13154	N/A	Enhatls21132	enhancer	E5877	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.43624	0.99979		PARD3	chr10	34109559	34815325	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1770
enhrx-116799	chr3	96705317	96705318	96986473	96986474	11329	hg38	N/A	N/A	N/A	Enhatls124988	enhancer	E5878	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.39735	0.99983		EPHA6	chr3	96814580	97761532	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	4928
enhrx-171973	chrX	40273671	40273672	40414419	40414420	11330	hg38	N/A	N/A	N/A	Enhatls184017	enhancer	E5879	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.29821	0.99984		ATP6AP2	chrX	40579371	40606848	162879	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	1690
enhrx-40202	chr12	71849271	71849272	71455491	71455492	11331	hg38	N/A	N/A	N/A	Enhatls43466	enhancer	E5880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32535	0.99988		TSPAN8	chr12	71125084	71441898	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5512
enhrx-40202	chr12	71849271	71849272	71455491	71455492	11332	hg38	N/A	N/A	N/A	Enhatls43466	enhancer	E5880	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.32535	0.99988		LGR5	chr12	71439797	71586310	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5512
enhrx-84423	chr19	39152900	39152901	38662260	38662261	11333	hg38	N/A	enh5125	fant56942	Enhatls90486	enhancer	E5881	|		|	NA	Minimal or weaker impact on cell fitness in T47D cells	Breast; Mammary gland	T47D cell	FOXA1	indirect	weak Significant	NA		0.25629	0.99989		ACTN4	chr19	38647648	38731589	0	|	|	|	CRISPR-Cas9	Deciphering essential cistromes using genome-wide CRISPR screens	https://doi.org/10.1073/pnas.1908155116	34723340	5393
enhrx-145513	chr6	138229864	138229892	137908727	137908755	11334	hg19(expected)	N/A	enh49167	N/A	Enhatls155535	enhancer	TT>A enhancer	|		|	GGTACTTCTCAACAAGATGACTAGTGCAT	"TT>A enhancer knockout reduces gene expression of TNFAIP3 leading to a loss of A20 protein and impaired TNF-?-induced receptor-mediated downregulation of NF-?B signaling, contributing to autoimmune disease mechanisms."	Human embryonic kidney (HEK) cells	HEK293T Cell line	TNFAIP3	direct	Significant	NA					TNFAIP3	chr6	137867213	137883314	25315	285bps			TALEN	TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus	https://doi.org/10.1038/gene.2016.4	26821284	7101
enhrx-145513	chr6	138230124	138230148	137908987	137909011	11335	hg19	N/A	enh49167	N/A	Enhatls155535	enhancer	TT>A enhancer	|		|	TCCATGAGGGTATCAGGACTTCCCA	"TT>A enhancer knockout reduces gene expression of TNFAIP3 leading to a loss of A20 protein and impaired TNF-?-induced receptor-mediated downregulation of NF-?B signaling, contributing to autoimmune disease mechanisms."	Human embryonic kidney (HEK) cells	HEK293T cell line	TNFAIP4	direct	Significant	NA					TNFAIP3	chr6	137867213	137883314	25315	285bps			TALEN	TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus	https://doi.org/10.1038/gene.2016.4	26821284	7101
enhrx-113184	chr3	27755291	27755341	27713800	27713850	11336	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-1				AGAGCGAACTCGTGCCGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9924818823133981					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756682	27756732	27715191	27715241	11337	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-10				TGCGCTTAGTTCCGTTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40038057962605622					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756501	27756551	27715010	27715060	11338	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-100				TACCCCGGGAGGGTCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.946232009886498					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756602	27756652	27715111	27715161	11339	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-101				GGACCCTCCACCCCACTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5360450679066409					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755334	27755384	27713843	27713893	11340	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-102				CTCTGGAGAGAATTCGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.53154654161499					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755661	27755711	27714170	27714220	11341	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-103				TGCATACTAGGAGACCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.68165903899874					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757062	27757112	27715571	27715621	11342	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-104				CCAGGCGCTCTGACAGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5846330406940772					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755753	27755803	27714262	27714312	11343	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-105				TGTATCTAATTAATCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2347767518726984					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757229	27757279	27715738	27715788	11344	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-106				AATAGCCCCATTCCACTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1822913961192558					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756271	27756321	27714780	27714830	11345	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-107				AGCAGGAGTTCGAGCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0620056580801327					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756271	27756321	27714780	27714830	11346	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-107				AGCAGGAGTTCGAGCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0620056580801327					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756977	27757027	27715486	27715536	11347	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-108				AGGCTCCCTGGGAACCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7816089706589828					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756934	27756984	27715443	27715493	11348	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-109				TCAGGGTCCCTGGGGCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.51763555535981					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757277	27757327	27715786	27715836	11349	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-11				ATACTGTAGTCATGCGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86825818911209052					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-lit84	chr3	27757447	27757497	27715956	27716006	11350	hg38					enhancer	EOMESe-1-110				TTAATAAATGTGGTTCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038788857640661228													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-113184	chr3	27755144	27755194	27713653	27713703	11351	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-111				GAGTCAGAAAGAACTTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5997224557203289					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757082	27757132	27715591	27715641	11352	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-112				TGGTCTCCAAGAGCCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.0884806911634453					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755428	27755478	27713937	27713987	11353	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-113				AACCAAAAAGTGTTTGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21849450736459691					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754913	27754963	27713422	27713472	11354	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-114				TCGGAAAGAAGAGACTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1132583357129979					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755264	27755314	27713773	27713823	11355	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-115				GGTTCCAGAATTCCTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8756507306796761					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756339	27756389	27714848	27714898	11356	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-116				GAAGGGAGACAGGACAGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9638975593448142					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756383	27756433	27714892	27714942	11357	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-117				ATTGGGCGCAGAAGGGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.87446792766338					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755443	27755493	27713952	27714002	11358	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-118				GGTGATGGAAAGAACACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8506794172858427					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755524	27755574	27714033	27714083	11359	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-119				TCAATAAATTGCAATGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39666519577889081					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756700	27756750	27715209	27715259	11360	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-12				GCGCAAGGTGAACTGCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9826272172387567					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755562	27755612	27714071	27714121	11361	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-120				TTGTTTATTTGGGGCAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01062516931529889					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755712	27755762	27714221	27714271	11362	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-121				CTTGATCTTTATTTAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.6064633300101541					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757413	27757463	27715922	27715972	11363	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-122				GCTCTGTCTTCTGTGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20556575733443519					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754865	27754915	27713374	27713424	11364	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-123				GTAATTTTTTAAATCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3056869862813269					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755535	27755585	27714044	27714094	11365	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-124				GCAATTTATTGATTTTATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.12334365215469					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756158	27756208	27714667	27714717	11366	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-125				TTTTTAAGATATATGTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756321	27756371	27714830	27714880	11367	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-126				CCCCAGAGGGACGGAGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6107833158552209					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756512	27756562	27715021	27715071	11368	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-127				GGTCCAGGAGGGGGCTGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.5659183274025938					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757241	27757291	27715750	27715800	11369	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-128				ATCTTCTTTTTTCCTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36919877442756521					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755305	27755355	27713814	27713864	11370	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-129				CTCCGGTCCCCACCCCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.910101145739759					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756352	27756402	27714861	27714911	11371	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-13				ACAGTCGAGGTACAAGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4457829358847034					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755207	27755257	27713716	27713766	11372	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-130				GCTATCCTGGGGGTGGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0477284813746621					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755351	27755401	27713860	27713910	11373	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-131				TCTAGAATTCTTTTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44559479985675821					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755173	27755223	27713682	27713732	11374	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-132				TCTGGAAGGGAAACTGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5878874721641889					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756075	27756125	27714584	27714634	11375	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-133				AAGGGGGCTGTTGGGGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.118177072204978					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755551	27755601	27714060	27714110	11376	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-134				ATTGTGGTTTTTTGTTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82727925395688373					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757325	27757375	27715834	27715884	11377	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-135				GTGGAGGTAGGGGATGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	11.49582327915823					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757159	27757209	27715668	27715718	11378	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-136				GGAGGGGGGCGGGGGAACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.032420076307993553					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755505	27755555	27714014	27714064	11379	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-137				CAGGAAAAAGCAGTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45479781547348969					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755394	27755444	27713903	27713953	11380	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-138				AGGGAAAAAAGGAAGAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4907482143220507					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757170	27757220	27715679	27715729	11381	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-139				GGCGGGGCGGGGGAGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756737	27756787	27715246	27715296	11382	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-14				GCGGCAGTGCACGGAACGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5832536793327758					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756370	27756420	27714879	27714929	11383	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-15				TGCGCCCAATTAAGGCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51864382353427563					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756035	27756085	27714544	27714594	11384	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-16				CCATCGCATCTCCCAATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5865616756380989					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756657	27756707	27715166	27715216	11385	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-17				CACGCTCCACGGGAAGACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.900169440286164					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756458	27756508	27714967	27715017	11386	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-18				ATTCTGCTAACTGTGTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8357698851995159					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756766	27756816	27715275	27715325	11387	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-19				GACGGGCGTGGCACTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8640754279126011					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756490	27756540	27714999	27715049	11388	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-2				AGCTAGACCTTTACCCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.10452705242993					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755074	27755124	27713583	27713633	11389	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-20				CTTGAAACCGGCTCCAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9072759678001088					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756285	27756335	27714794	27714844	11390	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-21				CGCGCCACCCGTGACCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.753690141612795					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756285	27756335	27714794	27714844	11391	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-21				CGCGCCACCCGTGACCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.753690141612795					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756800	27756850	27715309	27715359	11392	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-22				CTCCGCCCGGACTCGGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.246353366934805					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756564	27756614	27715073	27715123	11393	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-23				GATAAGCCTGGCGGGACGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7807697759466867					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755218	27755268	27713727	27713777	11394	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-24				GATGTAGAGTAGCTATCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8035899780482332					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756134	27756184	27714643	27714693	11395	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-25				TGACTGATTTAGATTCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61918329881228107					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755736	27755786	27714245	27714295	11396	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-26				TTGTTTATCGGTGTCATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3949417714950139					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756952	27757002	27715461	27715511	11397	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-27				CTTTGAGCGCCCACCAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53581647069922589					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755028	27755078	27713537	27713587	11398	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-28				GCCTCGAAACTCTCCATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.005374392927445					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755952	27756002	27714461	27714511	11399	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-29				TGCCGGGATATAGCAGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4993102839451531					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755086	27755136	27713595	27713645	11400	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-3				TCCAAATCCGGCCCAAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0368026250140936					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757095	27757145	27715604	27715654	11401	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-30				GCCTCGAAAACCTCCGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0037892000056692					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756988	27757038	27715497	27715547	11402	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-31				TAGGCCCACCTAGGCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8775796148310766					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756552	27756602	27715061	27715111	11403	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-32				AAGCCGTCTGCAGATAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7963175427640641					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756236	27756286	27714745	27714795	11404	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-33				ACGGCCTACTCAAAACACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.909366003503465					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755576	27755626	27714085	27714135	11405	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-34				CAAGAACGGAGATGTGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4286617806318169					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755004	27755054	27713513	27713563	11406	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-35				ACCGGGACCAAAAACAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4188592220772618					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757314	27757364	27715823	27715873	11407	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-36				TAGAGCCTTCCGTGGAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.2604750426284168					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757300	27757350	27715809	27715859	11408	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-37				AAGGCTCTAGAATCTCTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.976735124608056					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755186	27755236	27713695	27713745	11409	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-38				GGAGCCGCAGACGTCTGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1567269664441486					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756109	27756159	27714618	27714668	11410	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-39				GACTCATAGCCCCCCTATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7616210685427358					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756248	27756298	27714757	27714807	11411	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-4				GAGTAGGCCGTTCGGAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2105868839254423					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755929	27755979	27714438	27714488	11412	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-40				ACAGGACCCGAAATAGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1708047355225748					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755680	27755730	27714189	27714239	11413	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-41				GCGGAGAATGTAAACAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.74145708843742					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756439	27756489	27714948	27714998	11414	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-42				GCGGAAATGCAGCTGCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1121931678068124					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756671	27756721	27715180	27715230	11415	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-43				TGGAGCGTGGGCCAAATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.3243296080617277					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755842	27755892	27714351	27714401	11416	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-44				TAGAAACGTAAGTGGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1009211084686514					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755970	27756020	27714479	27714529	11417	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-45				CGGCAGTGATTAGCACTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4303947083096276					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755615	27755665	27714124	27714174	11418	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-46				CCGAGCCAGTATCTCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6837606462547408					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756524	27756574	27715033	27715083	11419	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-47				GGCTGGAAAGGTTTGCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8671607642142716					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756426	27756476	27714935	27714985	11420	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-48				TGCTAAGAGGATTAGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8679339062506326					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757046	27757096	27715555	27715605	11421	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-49				CGCCTGGCCACTAAGTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.575658963893908					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756205	27756255	27714714	27714764	11422	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-5				TGGCTCCCCGGTAAAGTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5659274197583963					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754963	27755013	27713472	27713522	11423	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-50				CTTTGATTCGCTTTAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16252661985665351					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755895	27755945	27714404	27714454	11424	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-51				TCGTACAGTAAAAAAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.107678673606812					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754884	27754934	27713393	27713443	11425	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-52				TTACATTCCTCCCCCTACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7214468989160809					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756813	27756863	27715322	27715372	11426	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-53				AGCTGCAGTCAAACTCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.867542669303651					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755638	27755688	27714147	27714197	11427	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-54				GCAGGGAACACCGCCTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8730655467967541					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756579	27756629	27715088	27715138	11428	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-55				ACGTCTGGCTGGGGGGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6826228946818951					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756185	27756235	27714694	27714744	11429	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-56				ATCTTCAACGCTTTTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38267066981823189					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755481	27755531	27713990	27714040	11430	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-57				AGTATTTCCAACTCCGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.406605287758361					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756963	27757013	27715472	27715522	11431	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-58				GGGCGCTCAAAGGGCCACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.446507919269882					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755817	27755867	27714326	27714376	11432	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-59				CCTTATCATAAGGTGTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67787587265148008					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754896	27754946	27713405	27713455	11433	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-6				TTCCGAATTAAACCTGCGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1904192013610696					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754987	27755037	27713496	27713546	11434	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-60				CGGCTGTAAAAAGGGAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0213252663484731					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757352	27757402	27715861	27715911	11435	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-61				GTTAAAGCTGAAAACGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0884718812199461					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755062	27755112	27713571	27713621	11436	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-62				CGTTGCTGCAGACTTGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2635190573653876					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757007	27757057	27715516	27715566	11437	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-63				ACTTGGGGCCACCCATCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3946865414049689					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755405	27755455	27713914	27713964	11438	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-64				GTTGGTTTGCGAGGGAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.336268676787026					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755604	27755654	27714113	27714163	11439	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-65				ATACTGGCTCGGGGGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2942676509125359					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756297	27756347	27714806	27714856	11440	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-66				CGGGTGGCGCGGGAAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2546434948555074					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756297	27756347	27714806	27714856	11441	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-66				CGGGTGGCGCGGGAAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2546434948555074					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756097	27756147	27714606	27714656	11442	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-67				GGAAGGCGCTGACCAGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3852813870681224					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757182	27757232	27715691	27715741	11443	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-68				ACAATGGGTGTTGGCGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1030319578573					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757024	27757074	27715533	27715583	11444	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-69				GGCTTTTTTCTAGGCTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27382820984958262					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755041	27755091	27713550	27713600	11445	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-7				CGTATCTTCCAAACCTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4692715416819109					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755322	27755372	27713831	27713881	11446	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-70				TTCGGAGCAGGACCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7278969013512446					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755698	27755748	27714207	27714257	11447	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-71				AAGATCAAGGGCTCGGCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8003844689463619					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754946	27754996	27713455	27713505	11448	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-72				CCGTGAGTCTGCTTTCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3992107676030949					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755363	27755413	27713872	27713922	11449	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-73				AGAATTCTAGAGGCTACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.567455456411607					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755790	27755840	27714299	27714349	11450	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-74				GGTGTCTGACACTCCATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4286980168830592					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756834	27756884	27715343	27715393	11451	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-75				CTACTGAGGCCGGCAGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0653722888651611					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756891	27756941	27715400	27715450	11452	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-76				TCAGCTTCTGCGCCCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9760767438027611					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757114	27757164	27715623	27715673	11453	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-77				AGGCTTGGTTAAGTCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.8369954265847337					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757213	27757263	27715722	27715772	11454	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-78				GGCTATTTCCTTACCCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.198996413550331					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756059	27756109	27714568	27714618	11455	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-79				GGTTGGATGCAGATGTAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7802555814242966					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756047	27756097	27714556	27714606	11456	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-8				TGCATCCAACCACCGAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.925121690281776					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756879	27756929	27715388	27715438	11457	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-80				TTCAGAAGAAAGCCGCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7639248497427182					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756788	27756838	27715297	27715347	11458	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-81				TCGGTCTGAGGCGCAGGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.77901823310636					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755877	27755927	27714386	27714436	11459	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-82				AGGGACTTTTCACAAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5455922158991688					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755250	27755300	27713759	27713809	11460	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-83				TCCTCCTGGGTGTAGAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6639080960852768					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755803	27755853	27714312	27714362	11461	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-84				ATGATAAGGCATTCCTAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.645326615440772					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755769	27755819	27714278	27714328	11462	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-85				AGATACATCTCTTCACAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49569762435201359					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756308	27756358	27714817	27714867	11463	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-86				GGAAGAACTCGGGCCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4973720624253062					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756308	27756358	27714817	27714867	11464	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-86				GGAAGAACTCGGGCCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4973720624253062					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755097	27755147	27713606	27713656	11465	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-87				CATATTTTCAGCCCATGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92932363294768838					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27757199	27757249	27715708	27715758	11466	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-88				CATTGTCCAGACTTCCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9231519709364706					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756613	27756663	27715122	27715172	11467	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-89				CCCACTCTTTGGACCTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0088121827777341					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755649	27755699	27714158	27714208	11468	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-9				CGCCTGCACCGGTGCATACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4087747541104374					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755459	27755509	27713968	27714018	11469	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-90				TGTTATTTGCCGTTTTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.166759485513133					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755911	27755961	27714420	27714470	11470	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-91				TGTACGATGCAAAAACATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.81327833121119					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755857	27755907	27714366	27714416	11471	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-92				CGTTTCTATTAAACACTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44274158108754041					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756717	27756767	27715226	27715276	11472	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-93				CGCTCTGCAAACAGTGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3197928392888789					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755982	27756032	27714491	27714541	11473	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-94				GCACTTTGGGGCTTTCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4183822706999933					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756625	27756675	27715134	27715184	11474	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-95				ACCTCCCAGGGTTCAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.8233320144448006					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756856	27756906	27715365	27715415	11475	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-96				GCGGCGGGTGCGCAGCGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8079048809538021					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27756641	27756691	27715150	27715200	11476	hg38	N/A	N/A	N/A	Enhatls121111	enhancer	EOMESe-1-97				ACGAAGGACAGCCCATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0224226193344057					EOMES	chr3	27715948	27722711	10				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755494	27755544	27714003	27714053	11477	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-98				AGTGCAAAGAGGACCTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8171182563951316					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27755724	27755774	27714233	27714283	11478	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-1-99				TTAAATAGAGGCTTGTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.406498640748608					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113137	chr3	27270443	27270493	27228952	27229002	11479	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-1				GGACCTCTAGGTATTAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1164759420185916					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270508	27270558	27229017	27229067	11480	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-10				CTCAGGGATACCCCCCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75350577385364126					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270290	27270340	27228799	27228849	11481	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-11				AATAGCTGGAACTCTGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.017344084581413479					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270551	27270601	27229060	27229110	11482	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-12				CTCAGTAAATAAAATACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1403617902891188					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270647	27270697	27229156	27229206	11483	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-13				CAAATTCACTGTCTTCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11492132285121739					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270531	27270581	27229040	27229090	11484	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-14				GAGTTGATGATTCACGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.025239696427779481					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270394	27270444	27228903	27228953	11485	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-15				GCTCTCAATTAGATGTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22509045414195639					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270602	27270652	27229111	27229161	11486	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-16				AAGCTTATCTCATTCTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76646732216885194					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270276	27270326	27228785	27228835	11487	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-17				GCCTGTCTGATCTGAATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087607126592134169					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270347	27270397	27228856	27228906	11488	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-18				GCTACCTCAGCTCCTCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095986987054249517					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270487	27270537	27228996	27229046	11489	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-2				AGTAGGAACCAGTTGTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19568104195829311					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270519	27270569	27229028	27229078	11490	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-3				CACGCTTCAGGCCAGTAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14559980829203281					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270375	27270425	27228884	27228934	11491	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-4				GAGGTTTTTATCAGGGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.145078537581997					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270431	27270481	27228940	27228990	11492	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-5				TCATGGAGACTGGGACCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.186195155485658					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270302	27270352	27228811	27228861	11493	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-6				TCTGGGATAGGAGTAAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5953689753283391					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270414	27270464	27228923	27228973	11494	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-7				AGCTCCCCCAGCCACCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27413771007771032					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270634	27270684	27229143	27229193	11495	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-8				TTCTATTGGGTTGGAATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0893423129933517					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27270334	27270384	27228843	27228893	11496	hg38	N/A	N/A	N/A	Enhatls121062	enhancer	EOMESe-10-9				CTCTGCCAGGCCAGCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.179415023054418					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255030	27255080	27213539	27213589	11497	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-1				GGTCCATGGATTCGGTCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38433490697992923					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255181	27255231	27213690	27213740	11498	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-10				AACATTACAACAGAGGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22154741563926139					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255141	27255191	27213650	27213700	11499	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-11				ATCTCCTCTTTTTGGAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69097763908852261					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255056	27255106	27213565	27213615	11500	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-12				TTGGAATTCCCTTGGCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045377095655436					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255227	27255277	27213736	27213786	11501	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-13				ACCAAATTCCAACCTGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081895607766181377					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255253	27255303	27213762	27213812	11502	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-14				AGCATCACACGACAGATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28357202152165512					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255075	27255125	27213584	27213634	11503	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-15				ACTAGTTTTTCAGGTTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1211440779182304					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255239	27255289	27213748	27213798	11504	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-16				TGTGATGCTACACCAGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22694118514273989					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255011	27255061	27213520	27213570	11505	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-17				GGGGCTTAAAATTTTAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01566886065191225					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255277	27255327	27213786	27213836	11506	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-18				AAAATACTTTGATTTTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.300796714065638					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255090	27255140	27213599	27213649	11507	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-19				AAACTAGTTCAGGCCGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.184795721999708					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255103	27255153	27213612	27213662	11508	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-2				TTGAGCACCCTTACCTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.028318220169422009					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255301	27255351	27213810	27213860	11509	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-20				TGTCAAAGGAATATATTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31091891483337741					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27254918	27254968	27213427	27213477	11510	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-3				GTAGAAACGATGACCAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25345170738909623					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255196	27255246	27213705	27213755	11511	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-4				GTCTTAGGACTGATCTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34112826837000809					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27254939	27254989	27213448	27213498	11512	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-5				ACTAACGTGACCAAAAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34328949145482152					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27254979	27255029	27213488	27213538	11513	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-6				TTGTCCAATATATGACTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072556717478029234					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27254905	27254955	27213414	27213464	11514	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-7				ACATTCTGGTTTGCCATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4069549363367792					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27255044	27255094	27213553	27213603	11515	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-8				TGGCCTACAGGATGGGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18858149220791351					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113137	chr3	27254996	27255046	27213505	27213555	11516	hg38	N/A	N/A	N/A	Enhatls121061	enhancer	EOMESe-11-9				AGTTTTGGTTTATAAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60660954122725874					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1266
enhrx-113136	chr3	27114626	27114676	27073135	27073185	11517	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-1				TTAAGGTGCTTAGTCCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.060071829924170643					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114808	27114858	27073317	27073367	11518	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-10				TTGGCTTATGTGAGAGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29874082518041478					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114706	27114756	27073215	27073265	11519	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-11				TGCTCCTGGTGAATCTTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1952381361803584					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114879	27114929	27073388	27073438	11520	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-12				TCACACCAGGCAATCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024693801295677411					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114755	27114805	27073264	27073314	11521	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-13				TTATGGTTATTGAATCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.170637909144131					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114410	27114460	27072919	27072969	11522	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-14				TCTGTGGACTTGAAAGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.972190670474595					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115127	27115177	27073636	27073686	11523	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-15				CCACAGGAAGAACTTGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03828244673886836					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115021	27115071	27073530	27073580	11524	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-16				GTTTGGAAGTAGTCAGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21902901315774881					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114427	27114477	27072936	27072986	11525	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-17				GTGGGTCTGCTTTGTCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6363013737190627					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114532	27114582	27073041	27073091	11526	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-18				CAAAACTGCTATTGGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42318099573458751					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115111	27115161	27073620	27073670	11527	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-19				GTTTCTGGGAGTGTATCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33494830675283632					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114594	27114644	27073103	27073153	11528	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-2				CATTGCTAACCACTAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027588013274376409					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114866	27114916	27073375	27073425	11529	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-20				AGAATGTTTTCTGTCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53899749838822031					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114609	27114659	27073118	27073168	11530	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-21				TAGCAATGCCACATCTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075786996434716244					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114919	27114969	27073428	27073478	11531	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-22				GAAATTGTCTGCACAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28247281411879088					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114668	27114718	27073177	27073227	11532	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-23				GGTAAACGTGGAGAGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.155317722714699					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114890	27114940	27073399	27073449	11533	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-24				AATCTCCTGAGGTTGAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16079833296356741					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114362	27114412	27072871	27072921	11534	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-25				AATCAATTTTGAGGCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28341177782842131					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115070	27115120	27073579	27073629	11535	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-26				CACAATGCTCAGTGCTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26249482331535628					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115096	27115146	27073605	27073655	11536	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-27				ACCAACTCAGCATCTGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16780017336433409					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114394	27114444	27072903	27072953	11537	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-28				AACAAATAAATGGAGCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061629729931795219					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114936	27114986	27073445	27073495	11538	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-29				AATAAAGGGATTAGGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25082339573476892					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114737	27114787	27073246	27073296	11539	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-3				GAGGGAAGGCTATGCCGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17687215610806789					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114485	27114535	27072994	27073044	11540	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-30				AATGCTAACTGCAGGGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024858460001490539					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114975	27115025	27073484	27073534	11541	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-31				TTCCTGGTCTGCTGGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24216620179428369					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114574	27114624	27073083	27073133	11542	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-32				GGGGAGGTCACAGACTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67190908731669408					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114723	27114773	27073232	27073282	11543	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-33				AGTAGGAAAAGAAGCCTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26466559736556661					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114827	27114877	27073336	27073386	11544	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-34				TAAGGAGGAAATGAAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35738872419011958					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114951	27115001	27073460	27073510	11545	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-35				ATTAGCATTTAGATAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114653	27114703	27073162	27073212	11546	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-36				TGAGGAGGAAAGGAAGCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39365858018377248					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114640	27114690	27073149	27073199	11547	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-37				AAGCACGTGGGAAGCCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2276572011753937					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114772	27114822	27073281	27073331	11548	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-38				TTTATTTGTCTTCCTTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.730962063210569					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114988	27115038	27073497	27073547	11549	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-39				AGACCAGGAAAGGAGAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15822884571450291					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114845	27114895	27073354	27073404	11550	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-4				CTAAGCGAGACTGAATTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.019335333649300731					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114445	27114495	27072954	27073004	11551	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-5				GCCGACTGAGTCTGGCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.868801328799301					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27115038	27115088	27073547	27073597	11552	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-6				TGCCACCTCTAACTGAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13537105020660131					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114516	27114566	27073025	27073075	11553	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-7				AGTTTTGTAGGTAGTCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.106024616246311					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114689	27114739	27073198	27073248	11554	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-8				GGAGCACTGTTTATTACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47891941750122219					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27114472	27114522	27072981	27073031	11555	hg38	N/A	enh54042	N/A	Enhatls121060	enhancer	EOMESe-12-9				AGTTAGCATTTCAGGTTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1038437238856455					NEK10	chr3	27106483	27369460	29920				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087536	27087586	27046045	27046095	11556	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-1				TCTCAGGGTAACGATCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2261490657844809					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087521	27087571	27046030	27046080	11557	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-10				AATTCAGCAGAACTGTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0308884286840016					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087494	27087544	27046003	27046053	11558	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-11				AGCTATCAGTTTACATTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020026590925333251					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087192	27087242	27045701	27045751	11559	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-12				ACTATGTGTAGGAAGTACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62063552213156215					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087580	27087630	27046089	27046139	11560	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-13				TTGTGGACAAATTGTGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20368681782606379					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087265	27087315	27045774	27045824	11561	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-14				TCTCTTATCTACCCATGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1346276233164689					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087319	27087369	27045828	27045878	11562	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-15				TAAATTGTGTATTCAGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.492609628268875					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087319	27087369	27045828	27045878	11563	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-15				TAAATTGTGTATTCAGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.492609628268875					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087221	27087271	27045730	27045780	11564	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-16				TTTGAGTTGTCCCACCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89252622917164015					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087207	27087257	27045716	27045766	11565	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-17				TACATTGGTTTGGTCCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073673991993211382					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087181	27087231	27045690	27045740	11566	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-2				AGAAGTCAGACACTATGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19375635138278319					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087340	27087390	27045849	27045899	11567	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-3				TACATGTGACAGGAGAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12896104707715461					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087370	27087420	27045879	27045929	11568	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-4				ACTTATGCTTTAGTCTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62199849468416391					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087284	27087334	27045793	27045843	11569	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-5				GAGACTAACATGCATTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.716185342917363					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087284	27087334	27045793	27045843	11570	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-5				GAGACTAACATGCATTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.716185342917363					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087560	27087610	27046069	27046119	11571	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-6				CAAGGAAATTACTTGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17229213224798551					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087236	27087286	27045745	27045795	11572	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-7				AACTCAAAGCAGAACTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.011260342361883851					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087253	27087303	27045762	27045812	11573	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-13-8				GGTGGGGGGCTTCCATGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0460567427873351					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27087475	27087525	27045984	27046034	11574	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-13-9				AGCTTATCTTCACAGGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28798246541830769					NEK10	chr3	27106483	27369460	58590				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085279	27085329	27043788	27043838	11575	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-1				CGTGTGAGTTTGCTTGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18268350944395681					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085335	27085385	27043844	27043894	11576	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-10				TAATTGCCCTGCCCCGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20091988832002011					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085213	27085263	27043722	27043772	11577	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-11				TAGCCAGTTGAGTACAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.801571493505004					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085268	27085318	27043777	27043827	11578	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-12				CAAACTCACACGTGTTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3418706626858844					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084927	27084977	27043436	27043486	11579	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-13				TGCTTGGCCCTAGCATTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1000065175492115					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085439	27085489	27043948	27043998	11580	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-14				GTGGAGAAGCCTGACCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085739365525538846					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085101	27085151	27043610	27043660	11581	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-15				CTGCATGTGGTGTCCACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30198608510106428					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085047	27085097	27043556	27043606	11582	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-16				ACCCACGGAGCGTCCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70501157717450791					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085173	27085223	27043682	27043732	11583	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-17				TGTAATGAGAATTGGATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11420326125844189					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085004	27085054	27043513	27043563	11584	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-18				AAAGAGGACACTCTTGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1134044782501869					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085304	27085354	27043813	27043863	11585	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-19				CTTTTTATGTTTTCCATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0084154520414013272					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085020	27085070	27043529	27043579	11586	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-2				CGAACCCAACCACTCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38227279241227169					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084811	27084861	27043320	27043370	11587	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-20				TGTGATGCCCTCCTTTGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49934354813896192					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085087	27085137	27043596	27043646	11588	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-21				CACCTAAGGTCAGAGACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26646147484960442					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085114	27085164	27043623	27043673	11589	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-22				TGGAGGGGAAAATCTGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19504505695710381					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084845	27084895	27043354	27043404	11590	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-23				GTACTGTGGTTCTAAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47365350457190419					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085073	27085123	27043582	27043632	11591	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-24				GACATCTGGCACTCTAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76316213599429938					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085200	27085250	27043709	27043759	11592	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-25				CAACTGGCTAAGGAACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26033770217823138					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084822	27084872	27043331	27043381	11593	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-26				GAGGGCATCACACGTTAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.099821325620604848					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085512	27085562	27044021	27044071	11594	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-27				TGGTGGGCAGTGGCTAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.537946933817697					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085471	27085521	27043980	27044030	11595	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-28				GGCTGTGGCCAGTGAAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17262376969068549					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084943	27084993	27043452	27043502	11596	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-29				CTCACAGTTGCAATGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051084094254518757					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085422	27085472	27043931	27043981	11597	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-3				TCCTTAAGTGAACTGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.188886801874874					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085458	27085508	27043967	27044017	11598	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-30				GAAACTAAGGGGTTTTCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31999190185283027					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084890	27084940	27043399	27043449	11599	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-31				TGTCTAATGGGAAAGTGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33322892082185518					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084903	27084953	27043412	27043462	11600	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-32				ATCTGGAGTTTACTGTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36367247354594251					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085060	27085110	27043569	27043619	11601	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-33				CTAAGACTGGACCCCACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50435808788597625					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085492	27085542	27044001	27044051	11602	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-34				TGGAAGCAACTGCAGTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62638167779291354					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084961	27085011	27043470	27043520	11603	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-35				GTGAGAGAAAATTCTAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.014398960525201419					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085398	27085448	27043907	27043957	11604	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-36				CAAACAAACGAAAAAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088814168544043587					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084874	27084924	27043383	27043433	11605	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-4				GGAATGGTATTCCATATATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.130980842604818					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084863	27084913	27043372	27043422	11606	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-5				AGTACAAAAGCCCGGATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49782724748233559					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085032	27085082	27043541	27043591	11607	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-6				GGTTGGGTTCGCAGGACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38408908894317662					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085291	27085341	27043800	27043850	11608	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-7				CTTGGATCAGGGACCATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36067907899347618					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085129	27085179	27043638	27043688	11609	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-8				GCTCACAGTATGTTCTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.200686441775011					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27085324	27085374	27043833	27043883	11610	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-14-9				AAGAAGTCCTTCCCTCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.214675793477912					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084063	27084113	27042572	27042622	11611	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-1				AGTGATAGGATAGTTGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51217471453217778					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084288	27084338	27042797	27042847	11612	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-10				CAGTGAGACTTTGAATAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01289001768952106					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084088	27084138	27042597	27042647	11613	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-11				TTGTTAAAAGTAAAAAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9453556868395379					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084133	27084183	27042642	27042692	11614	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-12				ACTTAAAATGAACATTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0056508753034821					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084323	27084373	27042832	27042882	11615	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-13				TTCAAGCTGGGAGCTGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42100801983545838					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084252	27084302	27042761	27042811	11616	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-14				TCTGATTGCTTCCTTTGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1870482781996772					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084241	27084291	27042750	27042800	11617	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-15				TTTCTGATTAACCTTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43032036376575611					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084147	27084197	27042656	27042706	11618	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-16				TTGGTTTGGTCCAGAAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4800511963326875					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084174	27084224	27042683	27042733	11619	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-2				TTTGAGGCAAGGAGGCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42780327777807808					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084189	27084239	27042698	27042748	11620	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-3				CTTGGGGGCTATCAGATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38432743505339612					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084203	27084253	27042712	27042762	11621	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-4				GATCACAGGTAGGAAACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39948194595163672					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084335	27084385	27042844	27042894	11622	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-5				TGTCAGTGTTAATTCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.096550319030323281					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084077	27084127	27042586	27042636	11623	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-6				AAAAAATTAAGGACAGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18616780071300251					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084158	27084208	27042667	27042717	11624	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-7				CAGAAAGGCAGGACAATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.486227339939181					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084439	27084489	27042948	27042998	11625	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-8				GCTAGCTTTAAAATTATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89709283017610741					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27084400	27084450	27042909	27042959	11626	hg38	N/A	enh70520	N/A	Enhatls121060	enhancer	EOMESe-15-9				ACATATGCTGACAATTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.410218636127408					NEK10	chr3	27106483	27369460	60644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077916	27077966	27036425	27036475	11627	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-1				TCACTAGCGAAAGATAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31791234170734689					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077566	27077616	27036075	27036125	11628	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-10				CTGAGTCAGATGTCAAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34733667238140092					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077783	27077833	27036292	27036342	11629	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-11				GCATTCACACCTCCCCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51706223404647933					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077765	27077815	27036274	27036324	11630	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-12				AATGCTGAGATAGAGTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2528951717687184					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077992	27078042	27036501	27036551	11631	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-13				AGGAGGAGAATGTACCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15317497828670021					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078046	27078096	27036555	27036605	11632	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-14				AGATTTCATGAAACTCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18513813014179431					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077871	27077921	27036380	27036430	11633	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-15				TAGAGGTTGTGAGTGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19717645250623331					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078027	27078077	27036536	27036586	11634	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-16				GTGGCTTTTAAACAAATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036052070601448993					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077806	27077856	27036315	27036365	11635	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-17				GTTCAGTTGTGACATGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.086694313524398617					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077844	27077894	27036353	27036403	11636	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-18				AGGGGGAAAGAGAAGCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1658778194246941					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077795	27077845	27036304	27036354	11637	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-19				ACATGATAAAGGCCTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67176579021216232					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077748	27077798	27036257	27036307	11638	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-2				CACAGGATTAGGGCACCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059462065134243278					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078116	27078166	27036625	27036675	11639	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-20				TTTAGTGCTTCTAATTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.19892648219095					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078070	27078120	27036579	27036629	11640	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-21				CCCTGATCTTCAGAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41736170270523548					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077660	27077710	27036169	27036219	11641	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-22				GCCAATTTGCATAATTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31801894303395389					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078101	27078151	27036610	27036660	11642	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-23				GCACTAAAAAAGATTAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57451471303027224					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077856	27077906	27036365	27036415	11643	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-24				TCTTTCCCCCTCCATCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19608318980113909					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077833	27077883	27036342	27036392	11644	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-25				GAAGCTAGTTGGGAGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76909788152356717					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27078012	27078062	27036521	27036571	11645	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-26				ATGTGTGGGGAGAGCATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.070037204592053093					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077621	27077671	27036130	27036180	11646	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-27				GAAGAGAGGAAGGGAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7590756940314149					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077607	27077657	27036116	27036166	11647	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-28				GAAAAAGAAGGAAGGAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8279424761641607					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077595	27077645	27036104	27036154	11648	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-29				GAAAAAAGAAAAGAAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23584491673686639					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077727	27077777	27036236	27036286	11649	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-3				GGGGAGCATTCCAAAACCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.274966086302682					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077684	27077734	27036193	27036243	11650	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-4				GAGGCAGCTAGTTGTTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36043187484238948					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077902	27077952	27036411	27036461	11651	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-5				TAGGTCAGGTCAGGTATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16919557212190969					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077710	27077760	27036219	27036269	11652	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-6				CGTGGGGCCTCATCTTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54157183225423966					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077977	27078027	27036486	27036536	11653	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-7				CCCATGATTTCTCAACCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52333674127094287					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077931	27077981	27036440	27036490	11654	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-8				GCTAGTGATTCTCTTACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0083205209765665911					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27077888	27077938	27036397	27036447	11655	hg38	N/A	N/A	N/A	Enhatls121060	enhancer	EOMESe-16-9				TATAGGTGGTGGAATGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30842080715314341					NEK10	chr3	27106483	27369460	65835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067479	27067529	27025988	27026038	11656	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-1				TATTTGTAGTCCCTCCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08767643008460993					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067492	27067542	27026001	27026051	11657	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-10				TCCCGGGGGGCTCCCACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.8134273291641572					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067199	27067249	27025708	27025758	11658	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-11				GTCTATTTCCCTTCTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1080673906700296					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067397	27067447	27025906	27025956	11659	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-12				GGAAGAGGCACTAGCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38309819332856138					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067177	27067227	27025686	27025736	11660	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-13				CTGATCTGTCAAATACTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55051986658868857					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067376	27067426	27025885	27025935	11661	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-14				TCCCACTGAGAAGCTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0097758030558159226					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067285	27067335	27025794	27025844	11662	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-15				AAAAGACTGTTGCTATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36431790868511671					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067159	27067209	27025668	27025718	11663	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-16				TATGGAAGTGTGAGAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51823106073037351					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067358	27067408	27025867	27025917	11664	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-17				TGGGAGGAAGTGTCAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12562444697116529					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067450	27067500	27025959	27026009	11665	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-18				CATCCTTGCCTCCTGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34408147401864969					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067134	27067184	27025643	27025693	11666	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-19				AGAGGAGGATGGATGGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48390484166132453					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067257	27067307	27025766	27025816	11667	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-2				GAAAAGCTTGTGACGTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088781692183033542					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067145	27067195	27025654	27025704	11668	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-20				AAAAGGAGGAGAGAGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.06328917910363					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067233	27067283	27025742	27025792	11669	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-3				CTGGTAGTCACACAACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057047792731503191					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067517	27067567	27026026	27026076	11670	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-4				TTGCCAATCTTCCAACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60731322300297008					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067435	27067485	27025944	27025994	11671	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-5				GCCTGAAAACTGACTCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39323718896824128					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067413	27067463	27025922	27025972	11672	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-6				CAGCAGGGGTCCTCTAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15615655285016161					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067210	27067260	27025719	27025769	11673	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-7				TTCTCACAGGGGCTCACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4107638421895291					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067505	27067555	27026014	27026064	11674	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-8				AAGATTGGCAACACCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38749440203878027					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27067323	27067373	27025832	27025882	11675	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-17-9				GTAACTTCCATGAAAGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1092459460277285					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063401	27063451	27021910	27021960	11676	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-1				GCCTTATTGATCTCACTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11985646894495761					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063480	27063530	27021989	27022039	11677	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-10				CCTGGCCCAGTGGGAAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.494779399397884					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063995	27064045	27022504	27022554	11678	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-11				GGAAATAGCTGCCACAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4777747653714412					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063634	27063684	27022143	27022193	11679	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-12				GATTATTGAAACAATGTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35136005892082822					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063830	27063880	27022339	27022389	11680	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-13				TATGGGGCTTCTCATTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30769683197718478					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063604	27063654	27022113	27022163	11681	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-14				AAGGCAGACCTGGCACCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17128825805117751					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063352	27063402	27021861	27021911	11682	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-15				GCATGGCTAAACAGAATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44196970770739952					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063974	27064024	27022483	27022533	11683	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-16				CAGATATGGTAAGGCAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.016918322886184					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063895	27063945	27022404	27022454	11684	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-17				CATGGGGACTGGCTTTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44762840271911958					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063463	27063513	27021972	27022022	11685	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-18				GCCAGGTTGCTGTATTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26305889344994632					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063795	27063845	27022304	27022354	11686	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-19				CATTCAGCTAGGAGCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26117703051829272					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063550	27063600	27022059	27022109	11687	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-2				CGCACTACCCTACCATCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0184494821681021					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063365	27063415	27021874	27021924	11688	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-20				TTAGCCATGCATACAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.021344818165154031					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063452	27063502	27021961	27022011	11689	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-21				GTATTTAAAAGGTGGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63623908023802944					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063848	27063898	27022357	27022407	11690	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-22				CTGAATGATGAGTGAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.012748637172932					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063619	27063669	27022128	27022178	11691	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-23				GTAGCAGGAAAGGAACCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37607430281762849					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063782	27063832	27022291	27022341	11692	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-24				TAGCTGAATGCAGATGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64450422528811735					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063534	27063584	27022043	27022093	11693	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-25				ATGAGAAGCTTTCCTTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20987313821894121					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063422	27063472	27021931	27021981	11694	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-26				GGAATGAGGAGAGCCAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1074072641221145					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063503	27063553	27022012	27022062	11695	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-27				TAAAATTCTATGGCATTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20793754766975					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063957	27064007	27022466	27022516	11696	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-28				TATCTGATTAAAACAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43884034448065512					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063683	27063733	27022192	27022242	11697	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-29				ATTGTTGTTTTAAGTCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0098408148005295557					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063760	27063810	27022269	27022319	11698	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-3				GAATCTCAGCTGTACTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1976153660440754					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063708	27063758	27022217	27022267	11699	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-30				CATTATTTCTCACAATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37561158477085571					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063435	27063485	27021944	27021994	11700	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-4				CCAATGAAGGTAAACTACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18772982046277539					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063813	27063863	27022322	27022372	11701	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-5				CCTGGTGTAGAGCCTCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49907358567467092					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063877	27063927	27022386	27022436	11702	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-6				TACTGTAAATTCGTTATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79565414203602824					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063592	27063642	27022101	27022151	11703	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-7				AGGTCTGCCTTTCATTCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25141098995539918					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063939	27063989	27022448	27022498	11704	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-8				TCTGCTCTAAATATGTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08639304267456388					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	27063576	27063626	27022085	27022135	11705	hg38	N/A	enh70519	N/A	Enhatls121060	enhancer	EOMESe-18-9				GGAGATATGCTGCATACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079557796511982					NEK10	chr3	27106483	27369460	78000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759717	26759767	26718226	26718276	11706	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-1				CCAACTGATGCTATATATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8314379544774223					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759916	26759966	26718425	26718475	11707	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-2				CCAAGGATGTAAGTGTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66912806240710621					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759835	26759885	26718344	26718394	11708	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-3				CAAAAGTGAAGCTATTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01754801734462488					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759878	26759928	26718387	26718437	11709	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-4				ATATCTTAAGAAAGGTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1467347393060572					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759818	26759868	26718327	26718377	11710	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-5				CTTTTGACTTATCTCTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.1661229347235036					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759866	26759916	26718375	26718425	11711	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-6				TCTTAAGATATCAGTCAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40814112372855471					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759772	26759822	26718281	26718331	11712	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-7				TTCTGAGGCACTAGGGCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29980479861319143					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759899	26759949	26718408	26718458	11713	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-8				GGACACACAGAGAGCCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52576114939136853					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26759787	26759837	26718296	26718346	11714	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-19-9				CAAAATACAGTCACATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13874414892211179					LRRC3B	chr3	26622771	26710776	6660				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113184	chr3	27754111	27754161	27712620	27712670	11715	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-1				GCACGTATGGAGTTCGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9132582836842289					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754044	27754094	27712553	27712603	11716	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-10				TGTGACGCGGGGGCACTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6450599420038849					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754243	27754293	27712752	27712802	11717	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-11				AATTCGATGACCAGCAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67815764019336688					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754383	27754433	27712892	27712942	11718	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-12				TTCGCAGGGCTTCCGCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3481258633665489					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754409	27754459	27712918	27712968	11719	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-13				CAAATGTGTGCGCTGAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68281225323545469					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753838	27753888	27712347	27712397	11720	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-14				CCAACTGTGTGGGGAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.80010829517903					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754081	27754131	27712590	27712640	11721	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-15				CAGCTGCCCAAATGCTAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.061961446421243					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753925	27753975	27712434	27712484	11722	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-16				GGGTTCGGAGCTTTTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9111901797835911					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753905	27753955	27712414	27712464	11723	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-17				CCACAAGGGCTTATAGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2137614744681589					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754353	27754403	27712862	27712912	11724	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-18				CCCGGAAGAAAATCCAGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.77488745025085					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753574	27753624	27712083	27712133	11725	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-19				TTGCAGTGAGATCGCGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.891427738109619					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754269	27754319	27712778	27712828	11726	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-2				CTCTCCCCCAACAAGACGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45617375596427928					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753725	27753775	27712234	27712284	11727	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-20				CGCGGGCAGCCTTCGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22336783821261039					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754068	27754118	27712577	27712627	11728	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-21				GCTAACCAGGCCCTCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6990876144706082					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753679	27753729	27712188	27712238	11729	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-22				TGGAGGAGCTCTCTTCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.565202352922483					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753699	27753749	27712208	27712258	11730	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-23				GGGGAGATCCTTACTCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78127958597946034					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753965	27754015	27712474	27712524	11731	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-24				CGTGTCTCTTAATGTGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74973919496487873					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753855	27753905	27712364	27712414	11732	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-25				TGTAACTTTAAGTTCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0787505683631089					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753662	27753712	27712171	27712221	11733	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-26				AGCAGCAGCTTTAAGAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5272775108968668					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754151	27754201	27712660	27712710	11734	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-27				GGACTCCCAGAGTTGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.539782389833614					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754198	27754248	27712707	27712757	11735	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-28				AAAAGTAAAACACGAGACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2780285495145161					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753630	27753680	27712139	27712189	11736	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-29				TTTTTTTGACGGAACTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56378743008543863					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754124	27754174	27712633	27712683	11737	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-3				TGTGTCGCCGAGGGCACGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5275547903392326					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754311	27754361	27712820	27712870	11738	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-30				CTTGGACAGTCTGAAGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.023705878015007					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754217	27754267	27712726	27712776	11739	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-31				TTTTCATTTAAGTCGTAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34407266632918809					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754057	27754107	27712566	27712616	11740	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-32				CACTTTAGGGACCATTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1263407038167372					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754095	27754145	27712604	27712654	11741	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-33				GGGCAGCTGAATCCTTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3428732815634108					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753741	27753791	27712250	27712300	11742	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-34				GCCCGCGGCCCAGAAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5655659804962658					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753807	27753857	27712316	27712366	11743	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-35				AGGACCCCACGCCTCACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2235265260420181					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753894	27753944	27712403	27712453	11744	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-36				AAGCCCTTGTGGGGACAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32753424343696341					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753760	27753810	27712269	27712319	11745	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-37				GAGGAGCCTGCAGACCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2063409285580242					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753710	27753760	27712219	27712269	11746	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-38				TACTCTCCATGGCCACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.858300847048463					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753791	27753841	27712300	27712350	11747	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-39				CTGCGGGACCTGGAGGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4208995946832808					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754010	27754060	27712519	27712569	11748	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-4				ATAATGCATTGCTTCGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.912489408133772					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753827	27753877	27712336	27712386	11749	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-40				CCTCCTCCACTCCAACTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.16328429939183					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754286	27754336	27712795	27712845	11750	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-41				GGAGAGGGGGGAGAAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.854491408821596					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753590	27753640	27712099	27712149	11751	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-42				AAAGAAAAAAAAGGACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082061941946718009					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753479	27753529	27711988	27712038	11752	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-43				ATACAAAAATCAGCCAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37983133374799227					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753551	27753601	27712060	27712110	11753	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-44				CACTTGAACCCGGGAGACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0591770331566679					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753523	27753573	27712032	27712082	11754	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-45				GCTACTCGGGAGGCTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.972187463910787					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753492	27753542	27712001	27712051	11755	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-46				CAGGCGTGCGCCACCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.394252481546161					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753619	27753669	27712128	27712178	11756	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-47				TTTTTTTTTTTTTTTTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0231304537798378					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753511	27753561	27712020	27712070	11757	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-48				TCCCGAGTAGCTGGGACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7630195517650868					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754033	27754083	27712542	27712592	11758	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-5				TCAGAGATCCATGTGACGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67022588799858818					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27753775	27753825	27712284	27712334	11759	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-6				CCGCGCGGAAACTCTGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6125292789931209					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754335	27754385	27712844	27712894	11760	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-7				TATCGCTTAGCTCCTGCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1222480410128619					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754364	27754414	27712873	27712923	11761	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-8				ATCCAGCGCAGGTCGGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2379491893111281					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27754397	27754447	27712906	27712956	11762	hg38	N/A	enh90175	N/A	Enhatls121111	enhancer	EOMESe-2-9				GCACACATTTGGGGTTCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.307504283124119					EOMES	chr3	27715948	27722711	1129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113136	chr3	26754094	26754144	26712603	26712653	11763	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-1				GCTGAAGATTTATCGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.367136254006259					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753892	26753942	26712401	26712451	11764	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-10				GTGAAAAGCCCATGGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08640321672494819					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754075	26754125	26712584	26712634	11765	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-11				CAGCAAAGCTTCAGTCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057826075782101569					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754006	26754056	26712515	26712565	11766	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-12				ATTCCTGCATCCCAGCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.164028868112189					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753921	26753971	26712430	26712480	11767	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-13				ACACTTTTAGCAAGTTTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0343377747988231					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754123	26754173	26712632	26712682	11768	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-14				ATAGTATAATATATCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754017	26754067	26712526	26712576	11769	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-15				CAGTCTGGCTTCCTTCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048552601636835557					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754162	26754212	26712671	26712721	11770	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-16				ATGTGTATTTCAGTTCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65262379776683044					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753849	26753899	26712358	26712408	11771	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-17				GCATGCAGAGCACTGTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5791705061491641					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753861	26753911	26712370	26712420	11772	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-18				CTGTGGCCAGGCTCTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2718910020510491					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753976	26754026	26712485	26712535	11773	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-19				AGATGTAAAATTCAGGATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.683053530547677					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754032	26754082	26712541	26712591	11774	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-2				GTTCGTAAAAGCAGACAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29532096521366441					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754181	26754231	26712690	26712740	11775	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-20				ACATTTTTTTCCTAAAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55907124604515945					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753827	26753877	26712336	26712386	11776	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-3				CTAATCCAGGACCTGTGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3329404327422601					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753814	26753864	26712323	26712373	11777	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-4				CAATCAGGGTCAGCTAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64918706159185358					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26754112	26754162	26712621	26712671	11778	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-5				ATATTATACTATTGTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.718524129716061					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753961	26754011	26712470	26712520	11779	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-6				TTACATCTAGGAGTTACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27207920368783528					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753838	26753888	26712347	26712397	11780	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-7				TGCTCTGCATGCCTCGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26854274662178429					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753876	26753926	26712385	26712435	11781	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-8				GCTCATGGTACACACACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9004878750533315					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113136	chr3	26753945	26753995	26712454	26712504	11782	hg38	N/A	N/A	N/A	Enhatls121058	enhancer	EOMESe-20-9				AGATCTAGTCTAGAAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55577679706585292					LRRC3B	chr3	26622771	26710776	9				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1265
enhrx-113132	chr3	26556133	26556183	26514642	26514692	11783	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-1				CAATAGACGGGCTGAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36145697844609681					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555941	26555991	26514450	26514500	11784	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-10				AAGAGAGGACACTAGCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46857531606228942					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556066	26556116	26514575	26514625	11785	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-11				TGCAGGCTCTCCTGCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.435659858683188					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555956	26556006	26514465	26514515	11786	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-12				CAGATGATAGAGGTCAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46879408199064132					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555979	26556029	26514488	26514538	11787	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-13				TGCTCAAGGCTGTGCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05119134670441175					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556309	26556359	26514818	26514868	11788	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-14				GTTCTGCTCACTGCAACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.667797167812026					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556325	26556375	26514834	26514884	11789	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-15				CACTTGAGCCTGGGTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0576843194664782					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556282	26556332	26514791	26514841	11790	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-16				CTTGCCCAGGCTGGAGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042440483020402632					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556430	26556480	26514939	26514989	11791	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-17				GCGATGGGGTATCACCGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37922964832304518					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556444	26556494	26514953	26515003	11792	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-18				CACGATCAAGCTGGCCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02322104432566419					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556269	26556319	26514778	26514828	11793	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-19				ACAGAGTCTCACTCTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19359350265188549					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556146	26556196	26514655	26514705	11794	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-2				GTTCTGAAGTCATCAATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45684765145968692					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556366	26556416	26514875	26514925	11795	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-20				CCCTGAGTAGCTGGGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3863407823612051					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556395	26556445	26514904	26514954	11796	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-21				AAAAACTTAGCCAGGCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64383044524677469					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556415	26556465	26514924	26514974	11797	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-22				TTTGTATTTTTAGTAGCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1720846809447395					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556354	26556404	26514863	26514913	11798	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-23				GCTACTCAGGGGGCTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5235536983410971					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556039	26556089	26514548	26514598	11799	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-3				ACTCTAGTGTCACATCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1004077813889545					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556028	26556078	26514537	26514587	11800	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-4				TGACACTAGAGTGCTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47092148218102081					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556091	26556141	26514600	26514650	11801	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-5				AAGGTGCAATTCTACTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040365141558931471					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555993	26556043	26514502	26514552	11802	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-6				CATAAACTGAGCTGTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27544546560596972					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555923	26555973	26514432	26514482	11803	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-7				AGCACTTGCTTGCTTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14501591853674739					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26556103	26556153	26514612	26514662	11804	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-8				AATTGCACCTTCACAATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.666739753324607					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113132	chr3	26555906	26555956	26514415	26514465	11805	hg38	N/A	N/A	N/A	Enhatls121054	enhancer	EOMESe-21-9				AGTGCTGTAGCTGAATGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28998802040331911					LRRC3B	chr3	26622771	26710776	84995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1261
enhrx-113131	chr3	26447771	26447821	26406280	26406330	11806	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-1				GTGTGGGAGAGCCCCATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60641187659620344					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447787	26447837	26406296	26406346	11807	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-10				AAGAAAGGGACCCCAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15225861048786341					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447701	26447751	26406210	26406260	11808	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-11				AGGAGGCTGAGTGCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063341656320784145					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447918	26447968	26406427	26406477	11809	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-12				CATGGGTCAGGGATCCAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33850222752905229					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447660	26447710	26406169	26406219	11810	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-13				ATAGGCAGGGGCTAGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.799851133898828					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447812	26447862	26406321	26406371	11811	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-14				TGTTGCTTACTTATCTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68084569921985738					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447801	26447851	26406310	26406360	11812	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-15				AAGTAAGCAACAACAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26612758203092951					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447857	26447907	26406366	26406416	11813	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-2				CTAATGAACCCTCCACTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37942653126124609					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447907	26447957	26406416	26406466	11814	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-3				AGCCGTTACTCCATGGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1162768641390968					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447932	26447982	26406441	26406491	11815	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-4				TTAATGGGCAGCATCCACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23700342592910639					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447838	26447888	26406347	26406397	11816	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-5				TTGGGGATTTACAGAGATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.450438962282484					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447649	26447699	26406158	26406208	11817	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-6				GCCCCTGCCTATTTGCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081741704785235431					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447678	26447728	26406187	26406237	11818	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-7				AAAGGTTTACAGGCTTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20842578705566769					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447758	26447808	26406267	26406317	11819	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-8				GATTATTGTTCTTCCCCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68321330591127638					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113131	chr3	26447736	26447786	26406245	26406295	11820	hg38	N/A	N/A	N/A	Enhatls121053	enhancer	EOMESe-22-9				CAACTGTTCTGAGAAGTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075749694169224474					LRRC3B	chr3	26622771	26710776	202198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1260
enhrx-113127	chr3	26392552	26392602	26351061	26351111	11821	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-1				TTGGAGCACCTACTGACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44507745732231768					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392364	26392414	26350873	26350923	11822	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-10				TACAGAATAGTGACATTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051782081782834118					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392386	26392436	26350895	26350945	11823	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-11				ATTATCTTTCTCTGGGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1985094687550911					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392541	26392591	26351050	26351100	11824	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-12				ACTGACTCATGGAACAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50285579680048265					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392608	26392658	26351117	26351167	11825	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-13				TCTTAGGGCTTCTTTCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33189038376932722					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392414	26392464	26350923	26350973	11826	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-14				CTGACAAAGGCAGTCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1884272012389987					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392485	26392535	26350994	26351044	11827	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-15				AAGAGACAGAAAAATCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51891009701984669					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392438	26392488	26350947	26350997	11828	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-16				GGAAAAAAAAAATAGAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.906223106126586					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392467	26392517	26350976	26351026	11829	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-2				CAAGGCTTTGCCAATCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36493200984141849					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392649	26392699	26351158	26351208	11830	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-3				GTAGAGCTTCAAAGGCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50927876714363707					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392514	26392564	26351023	26351073	11831	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-4				ATTCATTTGCTTGTATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5987457613854964					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392593	26392643	26351102	26351152	11832	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-5				TAGCATCAGCTCACCTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15715833188173639					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392530	26392580	26351039	26351089	11833	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-6				GAACAGGAATGGAAAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42756147431033359					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392427	26392477	26350936	26350986	11834	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-7				ATAGAATTCAGGACTGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.099842437736015838					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392571	26392621	26351080	26351130	11835	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-8				ATCTATGTTGCTGTTCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80527564456490608					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26392626	26392676	26351135	26351185	11836	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-23-9				TCTGGTATTTTGGTTTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19532070616133049					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350225	26350275	26308734	26308784	11837	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-1				GCACTCCTGAGGCGAACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0231487401696291					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350248	26350298	26308757	26308807	11838	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-10				ATATTGAAAGCATGCCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12849401464421331					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350294	26350344	26308803	26308853	11839	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-11				CAGTTGAGTTGGTGCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25357356298929967					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350280	26350330	26308789	26308839	11840	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-12				CAACATACTTCTGCCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4647555809434834					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350108	26350158	26308617	26308667	11841	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-13				GTCTGGTGAGGAGGAGGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4298319304620142					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350263	26350313	26308772	26308822	11842	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-14				ATGTTGTAAAAGTGGCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31708722191636762					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350348	26350398	26308857	26308907	11843	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-15				GGTAGAGGAGGAAATGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59961881954542084					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350383	26350433	26308892	26308942	11844	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-16				TTCACTTTTGGAGCAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.496381778271873					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350087	26350137	26308596	26308646	11845	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-17				GGTTATATTTGCATTTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1993571180567311					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350069	26350119	26308578	26308628	11846	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-18				AAAGGGCTAAGTAGGAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07130027438919484					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350317	26350367	26308826	26308876	11847	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-2				TAGCTCTTGCCTTATCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36138275061474451					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350236	26350286	26308745	26308795	11848	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-3				GCTTTCAATATGCACTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54051687960488337					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350133	26350183	26308642	26308692	11849	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-4				TAGATGAACTTGCCCAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2438777697739537					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350191	26350241	26308700	26308750	11850	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-5				CAGACGAAAGCATGCCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42253098040751852					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350205	26350255	26308714	26308764	11851	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-6				TGGAGGTGAAAGTTCCATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.096032523106907					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350305	26350355	26308814	26308864	11852	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-7				TATCAAACAGGCAGTTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1006555437839157					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350360	26350410	26308869	26308919	11853	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-8				GCACTTTTATAAGGTAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2970184680861338					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26350121	26350171	26308630	26308680	11854	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-24-9				CTCACCAGACATCCCCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0047928492353724768					LRRC3B	chr3	26622771	26710776	256302				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219355	26219405	26177864	26177914	11855	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-1				ACCCGGTGCTTCTGTCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02510259859991399					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219392	26219442	26177901	26177951	11856	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-10				GTTATCTAAAGTTAAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219414	26219464	26177923	26177973	11857	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-11				TGCCTAGGCACATAGTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.115151979412373					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219429	26219479	26177938	26177988	11858	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-12				TCACAAAAAGATCATTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024476184900568861					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219467	26219517	26177976	26178026	11859	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-13				TTCTTTGTGCTTCTTGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.376449272176384					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219316	26219366	26177825	26177875	11860	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-14				AAATCTGCTGTTAATCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15208917250489229					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219257	26219307	26177766	26177816	11861	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-2				TCTTTATAAGGCTAAAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-8.45866765725776					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219204	26219254	26177713	26177763	11862	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-3				AGAGAAACTAAGATTCATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8192125163577071					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219329	26219379	26177838	26177888	11863	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-4				ATCTGATAGGTTTTCCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45130851444989578					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219190	26219240	26177699	26177749	11864	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-5				TCATACAGGAAGGAAAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41231577638308992					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219245	26219295	26177754	26177804	11865	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-6				TGATAATTGTTTTCTTTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4382154161724561					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219494	26219544	26178003	26178053	11866	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-7				CTAGGTCTTTAGCAAGACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26698302787877759					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219288	26219338	26177797	26177847	11867	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-8				CAGAGACCCTGTAAGCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61480727461978957					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26219343	26219393	26177852	26177902	11868	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-25-9				AAGCACCGGGTAACCCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27776088249539888					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205913	26205963	26164422	26164472	11869	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-1				GACCTAGCTAGGCCTGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70777920129004168					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205994	26206044	26164503	26164553	11870	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-10				ACTCAGTGATGCTTGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24058499887437759					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205803	26205853	26164312	26164362	11871	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-11				AGGTGGGGGAGGGCTAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75001136844830307					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205940	26205990	26164449	26164499	11872	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-12				TGACTTCTCCCCTCCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1035104125115418					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205751	26205801	26164260	26164310	11873	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-13				TGGAACTAAAGGCATAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6605052521735191					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205779	26205829	26164288	26164338	11874	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-14				CTTTTTAAGAGGAAATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96660787296607631					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205890	26205940	26164399	26164449	11875	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-15				AGCAGAGGCTGAGGAAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8558844782817584					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205792	26205842	26164301	26164351	11876	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-16				AATTGCTGGGCAGGTGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.552506982646368					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205902	26205952	26164411	26164461	11877	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-17				GGAAGAATTGGGACCTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.976438910354381					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205954	26206004	26164463	26164513	11878	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-2				GAGAAGTCAGATGGGTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.560139878341956					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205875	26205925	26164384	26164434	11879	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-4				ATTACAGGGTTTGGGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35921104869316839					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205821	26205871	26164330	26164380	11880	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-5				TGCGGAACTAAACTGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71571274077374769					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205927	26205977	26164436	26164486	11881	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-6				TGTTGAGGGGCAGCCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079806275357782036					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205768	26205818	26164277	26164327	11882	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-7				GTTCCAGCCACCTTTTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1195727933102653					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205840	26205890	26164349	26164399	11883	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-8				TCTCCTCCTCACACCCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0870906807184107					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26205860	26205910	26164369	26164419	11884	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-26-9				AGAGGTGATAAAAGGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42314306252556849					OXSM	chr3	25783072	25794534	314051				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103656	26103706	26062165	26062215	11885	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-1				TCATCTACCAGGGACATTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43353435234601961					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103235	26103285	26061744	26061794	11886	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-10				AATGCATGAACCTCAGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1680856125272637					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103561	26103611	26062070	26062120	11887	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-11				ATACCATTGATAGTAATCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.66578458794416					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103249	26103299	26061758	26061808	11888	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-12				TCATGCATTGATTATTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90347796796018165					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103693	26103743	26062202	26062252	11889	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-13				GAAGGGTCTCTTGAGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75498359317213437					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103418	26103468	26061927	26061977	11890	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-14				ATATTAGAGGTTGGTTAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0189861605953586					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103181	26103231	26061690	26061740	11891	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-15				AACTGCAGGATACTTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39231650806131257					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103328	26103378	26061837	26061887	11892	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-16				GTCTGGATCTCAGATTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.206418615557137					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103497	26103547	26062006	26062056	11893	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-17				TAAGAAGAATGATAGTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103269	26103319	26061778	26061828	11894	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-18				AGGTAGAGATATATAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8595472353369962					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103451	26103501	26061960	26062010	11895	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-19				TATGGTTTTATTGCTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.017026089285143861					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103293	26103343	26061802	26061852	11896	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-2				ACAAACCCCTACACTCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044522247515221942					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103602	26103652	26062111	26062161	11897	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-20				GAACCTCAGAGCTTAGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12008731661680221					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103211	26103261	26061720	26061770	11898	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-21				TACTTTTGTATCTATACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67121960863698293					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103523	26103573	26062032	26062082	11899	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-22				ATCTGAAAATTGCTCTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.079649847772525387					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103382	26103432	26061891	26061941	11900	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-23				GCACAGAACAGAAAACTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32100231880677421					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103197	26103247	26061706	26061756	11901	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-24				ACAAAAGTAAGCATGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58555598133946718					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103467	26103517	26061976	26062026	11902	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-25				AGCAGTTCCCTAAGTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35649963763643172					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103360	26103410	26061869	26061919	11903	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-26				GGAGAACTGGAGTGAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15611181446130651					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103147	26103197	26061656	26061706	11904	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-27				CAGTGTCAGGCTTGGGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.339583262880333					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103405	26103455	26061914	26061964	11905	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-3				GGGCAGGCCACACATATTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10728178346903169					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103347	26103397	26061856	26061906	11906	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-4				AGACTCCCTCAGCGGAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42236127514531419					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103433	26103483	26061942	26061992	11907	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-5				TAGGGAGGCTTTAGGTCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.375769185837706					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103134	26103184	26061643	26061693	11908	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-6				ATAACGGCAGCGTCAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034464371877204719					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103645	26103695	26062154	26062204	11909	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-7				CAGAGGCCTTATCATCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1050771076493916					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103628	26103678	26062137	26062187	11910	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-8				TCCTAGCAACAATACCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22491928761769411					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26103164	26103214	26061673	26061723	11911	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-27-9				GCAGTTTATGATAGCATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.385769566300933					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092353	26092403	26050862	26050912	11912	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-1				ATGGCACCACCTAGGCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1067740030321197					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092305	26092355	26050814	26050864	11913	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-10				ATTACCTCTGTTTGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095939032561679669					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092262	26092312	26050771	26050821	11914	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-11				AAAACTTGCAACTAATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33587364411454113					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092378	26092428	26050887	26050937	11915	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-12				CACTTGCAAAAAATCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1668669882306518					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092446	26092496	26050955	26051005	11916	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-13				CCACTGTGTGAAATCAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6510981353933083					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092412	26092462	26050921	26050971	11917	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-14				AATGAAGGATAACACTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53322327399967684					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092635	26092685	26051144	26051194	11918	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-15				AGAGAATGTGTTTCTCAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097516661611464259					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092320	26092370	26050829	26050879	11919	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-16				GAAGAAGGAGGATGCTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.168062152588939					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092490	26092540	26050999	26051049	11920	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-17				AAGTTTCTCAGTTTTGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3480029695978118					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092553	26092603	26051062	26051112	11921	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-18				AGAAACAAGTTTGTTGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30370782941538738					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092650	26092700	26051159	26051209	11922	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-19				CATTCTCTGCTTCTTTATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21902118502357129					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092157	26092207	26050666	26050716	11923	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-2				TGGTTCCAGCTTACCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2466853133281546					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092183	26092233	26050692	26050742	11924	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-20				AAATGAATGTAAAAATTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51635329894378579					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092577	26092627	26051086	26051136	11925	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-21				CATAGTTTTACAGATTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16773951590230329					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092624	26092674	26051133	26051183	11926	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-3				TTCTCAAGTGGGCTAAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44418692247536851					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092250	26092300	26050759	26050809	11927	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-4				TAATGCTGAGGTCTTAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.958274965226713					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092427	26092477	26050936	26050986	11928	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-5				GTGGAACCAACATGAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57102989036051544					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092200	26092250	26050709	26050759	11929	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-6				AACCGCTTTAGAAAATACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.231916393136457					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092475	26092525	26050984	26051034	11930	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-7				AGAAACTTATTAGAATCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062688348245217448					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092459	26092509	26050968	26051018	11931	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-8				TCAAAGCAGGCAAACACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.610855378893304					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113127	chr3	26092510	26092560	26051019	26051069	11932	hg38	N/A	N/A	N/A	Enhatls121049	enhancer	EOMESe-28-9				TGGTGTGACTTTTCTTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097007316489856041					OXSM	chr3	25783072	25794534	212451				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1256
enhrx-113184	chr3	27722432	27722482	27680941	27680991	11933	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-1				CCACTACAAGCAGATCGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29856652151297558					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722513	27722563	27681022	27681072	11934	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-10				TGGCTTGGAATTCTCAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28695099397534279					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722371	27722421	27680880	27680930	11935	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-11				GCATGCTGAGCATGCCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2644864169336143					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723149	27723199	27681658	27681708	11936	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-12				CATATGAGATAGCTGATGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.709356275429381					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722388	27722438	27680897	27680947	11937	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-13				GCATGCCAGACCACAGACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10741385208840851					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722785	27722835	27681294	27681344	11938	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-14				ATGAGGACACCCAGTCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24852065309549529					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722572	27722622	27681081	27681131	11939	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-15				GACTTGCAGGATTTAGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088057087320471544					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722421	27722471	27680930	27680980	11940	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-16				TGCTTGTAGTGGAGTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10388917553338831					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722452	27722502	27680961	27681011	11941	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-17				CGGTGAGTGCTTAAACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42900948428543328					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722326	27722376	27680835	27680885	11942	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-18				TGACACTTGCTTTACCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1138084974008378					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722338	27722388	27680847	27680897	11943	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-19				TACCCTGCTGGAGCTCATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42684641968778358					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722893	27722943	27681402	27681452	11944	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-2				ATGACGAAAGACGAGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.191989637567852					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722718	27722768	27681227	27681277	11945	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-20				TGTGAATGCTTTTAGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21873338713082191					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722695	27722745	27681204	27681254	11946	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-21				TAGGCAAGTGATTAAGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3261375801070952					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722908	27722958	27681417	27681467	11947	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-22				AAGTCATCTTAATTCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66914605626814772					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722585	27722635	27681094	27681144	11948	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-23				GTTTAAGGAGGAGGACTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11284649320925309					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723007	27723057	27681516	27681566	11949	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-24				AGTTCAACTTCTTGTAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.04914001471770528					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723066	27723116	27681575	27681625	11950	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-25				AGAGGTGACATCAGAAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060594767510794782					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723098	27723148	27681607	27681657	11951	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-26				GGTTTGGAATGAGCTGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.289368873572953					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722757	27722807	27681266	27681316	11952	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-27				AATGTTTGGTCTCAGTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29859656651269612					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722357	27722407	27680866	27680916	11953	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-28				AAGGACAATGGCAGCCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35500402553540722					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722489	27722539	27680998	27681048	11954	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-29				GCTTAAAGTAATGAGACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41086494743269142					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722857	27722907	27681366	27681416	11955	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-3				TTCGTTGCCCACTAGAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.300380461806746					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723036	27723086	27681545	27681595	11956	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-30				TGATAAAAACAATGACTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62616152876736519					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722659	27722709	27681168	27681218	11957	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-31				GAAACAAGAACAAGGCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1740345535927359					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722979	27723029	27681488	27681538	11958	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-32				AGGTTCTGTTTGAGCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1875705497673584					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722617	27722667	27681126	27681176	11959	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-33				GGGGATTTCAGAAAGGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0182741621892192					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722405	27722455	27680914	27680964	11960	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-34				CCAAGGTCTCAGCTTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01813219876427986					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723048	27723098	27681557	27681607	11961	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-35				TGACTGGTGGGAGAAAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72443986637520019					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722256	27722306	27680765	27680815	11962	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-36				CACTGCACCAGGCTGCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39032514794116457					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722733	27722783	27681242	27681292	11963	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-37				CATTCACATTTTAATTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63843792322151827					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722190	27722240	27680699	27680749	11964	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-38				GGATTGCTGAGGCCAGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.567517796598684					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722201	27722251	27680710	27680760	11965	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-39				CTGAGGCAAGAGGATTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.029298634941503109					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722533	27722583	27681042	27681092	11966	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-4				AACAGGTCGAGTTCTTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24195426137316181					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722228	27722278	27680737	27680787	11967	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-40				TGCTTGTAATTTCATTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06099076723896435					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722802	27722852	27681311	27681361	11968	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-41				TTTTTTTTCTGAGAGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9308469948482769					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722178	27722228	27680687	27680737	11969	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-42				TCAGGCTGGTCTCCAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.09829899127259					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722245	27722295	27680754	27680804	11970	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-43				CAAGCATGAGCCACTGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.531009895106628					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722951	27723001	27681460	27681510	11971	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-5				ACTCAATCTGCTAGTCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.067725698447229					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27723077	27723127	27681586	27681636	11972	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-6				CAGAAAACGGGGAAATCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36502575417792282					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722600	27722650	27681109	27681159	11973	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-7				ATCCCCAGCCCTTTAGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31412191859153982					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722556	27722606	27681065	27681115	11974	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-8				GAGACGGCAACAAAAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038181567976679043					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27722271	27722321	27680780	27680830	11975	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-3-9				GATTCCTAGTAAAAACCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26930707576908341					EOMES	chr3	27715948	27722711	32034				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715271	27715321	27673780	27673830	11976	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-1				AGTTCCTTCTCCAACACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65299480297420331					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715330	27715380	27673839	27673889	11977	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-10				CTCACTATCACTAGAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.321472395467869					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715242	27715292	27673751	27673801	11978	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-11				TTTCAAGGTGAGATTGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34448660349807092					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715287	27715337	27673796	27673846	11979	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-12				AGGAACTGGGGGGAGGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.632595985340555					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715369	27715419	27673878	27673928	11980	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-13				CTGATGGTTTTATAAGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051966006585230318					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715353	27715403	27673862	27673912	11981	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-14				TGAGTTCTCATGAGATCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96263683966540781					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715300	27715350	27673809	27673859	11982	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-15				AGGTGATTGGATCATGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25457542113010462					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715206	27715256	27673715	27673765	11983	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-2				GTAGAGAAAACCAACTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62006895957575714					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715257	27715307	27673766	27673816	11984	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-3				CACCCAGGGATTACATTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16053520480148051					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715153	27715203	27673662	27673712	11985	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-4				CAGAAGGAAATAATGATTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2147516259451713					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715170	27715220	27673679	27673729	11986	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-5				TAGAGGAGAATAAGTGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81486779207482485					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715392	27715442	27673901	27673951	11987	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-6				GAAGCAAGCAAAAGAGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47190712166580689					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715137	27715187	27673646	27673696	11988	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-7				AACAACCCAAAGTAAACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068388585932747367					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715412	27715462	27673921	27673971	11989	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-8				TTCTTCTTCCTGCTGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.560894653493428					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27715105	27715155	27673614	27673664	11990	hg38	N/A	enh20435	N/A	Enhatls121111	enhancer	EOMESe-4-9				TTTCTAGTTTCTTAAGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.152257312806177					EOMES	chr3	27715948	27722711	38388				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708625	27708675	27667134	27667184	11991	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-1				TAAGATGCCTCCCGTTATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32787208123564238					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708302	27708352	27666811	27666861	11992	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-10				CACAACCGCAGCATGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14999535805586461					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708442	27708492	27666951	27667001	11993	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-11				GCAACCATCCACAAAAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1889599277815906					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708036	27708086	27666545	27666595	11994	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-12				GTCTGAATGCAACACACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21303620724025671					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708508	27708558	27667017	27667067	11995	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-13				GTCTCATCCTTATGCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031011941296724979					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708013	27708063	27666522	27666572	11996	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-14				CTTGAGTAGAGGATAGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.984149735928279					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708013	27708063	27666522	27666572	11997	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-14				CTTGAGTAGAGGATAGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.984149735928279					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707847	27707897	27666356	27666406	11998	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-15				GATTCTGAGAACTCAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38131875320978442					EOMES	chr3	27715948	27722711	49554				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707847	27707897	27666356	27666406	11999	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-15				GATTCTGAGAACTCAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38131875320978442					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708052	27708102	27666561	27666611	12000	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-16				TTGAGCCAGAAACAAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.179673181271045					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708553	27708603	27667062	27667112	12001	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-17				GAAGGTAGTATGGGGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22266031650117241					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708473	27708523	27666982	27667032	12002	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-18				CTCAGCATTTGAACAGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28862775526653311					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707963	27708013	27666472	27666522	12003	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-19				TCAGGACTGTTGTTGTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40792220578385141					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708096	27708146	27666605	27666655	12004	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-2				GCAGCTCTTAAGCACTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.013041843239435391					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707980	27708030	27666489	27666539	12005	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-20				TCCTGAAAGCACAAAGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90054668673553617					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707980	27708030	27666489	27666539	12006	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-20				TCCTGAAAGCACAAAGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90054668673553617					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708123	27708173	27666632	27666682	12007	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-21				ATGTTTTGGGGATTAGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.089927101718638686					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708582	27708632	27667091	27667141	12008	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-22				TTTGTTTCATATACCCTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50888913691603022					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708143	27708193	27666652	27666702	12009	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-23				CATTTCTATGGGATAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85295421884231992					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708531	27708581	27667040	27667090	12010	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-24				CTTTCTAATACTTCCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2466040616406391					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707901	27707951	27666410	27666460	12011	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-25				TCTCCCACAGCTGTTTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56085383878468109					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708242	27708292	27666751	27666801	12012	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-26				CTTTAGGTTTGTGGTGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14836193322742219					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707791	27707841	27666300	27666350	12013	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-27				TTTTTTCTACTAATGGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57775399844311237					EOMES	chr3	27715948	27722711	49554				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707818	27707868	27666327	27666377	12014	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-28				TTCTGTTTCTTCATGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24339212700613749					EOMES	chr3	27715948	27722711	49554				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708313	27708363	27666822	27666872	12015	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-29				CATGAAATGAGGAAGCAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1437753715132272					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708169	27708219	27666678	27666728	12016	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-3				AATTAGCAGGAGTCTACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17851883856306061					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708377	27708427	27666886	27666936	12017	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-30				TCTGCTGCCTCCCACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01498522416760957					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708401	27708451	27666910	27666960	12018	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-31				CTCAGACCTGGCTCCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46674393176347639					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707829	27707879	27666338	27666388	12019	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-32				GAAGAAACAGAAGCTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33447337289758922					EOMES	chr3	27715948	27722711	49554				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708636	27708686	27667145	27667195	12020	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-33				TCTTGAGACTTCCAGTATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.618324121804603					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708388	27708438	27666897	27666947	12021	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-34				CCACCAGCCAGGGCCGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.032032373443008827					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708276	27708326	27666785	27666835	12022	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-35				TTTACAGTTTGCTTTTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28014402703939878					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708196	27708246	27666705	27666755	12023	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-36				AACATTTTAAAAGATGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55235434788709492					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708258	27708308	27666767	27666817	12024	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-37				GTAGGAATTTTGTTTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13544506955575761					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708182	27708232	27666691	27666741	12025	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-38				TAAAATGTTTCTAAATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.22207860151129					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708413	27708463	27666922	27666972	12026	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-4				GTGCTACTATTTCTCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14117303879672941					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27707941	27707991	27666450	27666500	12027	hg38	N/A	enh35288	fant11545	Enhatls121111	enhancer	EOMESe-5-5				GGTCTTTCGCCAAAGTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.011688222711625359					EOMES	chr3	27715948	27722711	49418				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708024	27708074	27666533	27666583	12028	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-6				TGCATTCAGACCTTGAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1040389414146273					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708335	27708385	27666844	27666894	12029	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-7				GTGCAGCACAAACTGTAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1043622575291451					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708602	27708652	27667111	27667161	12030	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-8				AAATAGATTGTTGGAGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20193975182858531					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27708569	27708619	27667078	27667128	12031	hg38	N/A	enh35288	N/A	Enhatls121111	enhancer	EOMESe-5-9				GGTTGGGGGAATACCAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12631417935737349					EOMES	chr3	27715948	27722711	46931				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674383	27674433	27632892	27632942	12032	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6				CAGCGGCGGCGCGGAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0515143456297389					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674530	27674580	27633039	27633089	12033	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-1				GACGAGGCGTAAGACCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44504879908309308					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674616	27674666	27633125	27633175	12034	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-10				GAGCTGGATGCGTCGGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0189861605953586					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674301	27674351	27632810	27632860	12035	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-11				CCCGCGCAGGCAAAGGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1611374115420674					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674808	27674858	27633317	27633367	12036	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-12				AGCCTCTTCCGCAATGTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.223450782457553					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674854	27674904	27633363	27633413	12037	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-13				TCGTAAGCTGGTCTTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1160091863823255					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674063	27674113	27632572	27632622	12038	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-14				GGAGAACGTGGGGTGTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14901041509624369					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674090	27674140	27632599	27632649	12039	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-15				ATATCTAGGTCTCATTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36816828179412958					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674367	27674417	27632876	27632926	12040	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-16				GCAGCGGCGGACGCTCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38782320067555431					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674632	27674682	27633141	27633191	12041	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-17				CCAGCTCGTTGAGGAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1232990370780849					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674105	27674155	27632614	27632664	12042	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-18				TGTTGTGGATACAGCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16394591457656019					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674452	27674502	27632961	27633011	12043	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-19				CGCTGCCTCCGCGCCATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.114783104741627					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674193	27674243	27632702	27632752	12044	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-2				CTGGCGGCTATCATTTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25893763290203159					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674490	27674540	27632999	27633049	12045	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-20				GGCAGTGAAACGCCAGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0050507698231821961					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674466	27674516	27632975	27633025	12046	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-21				CATGGCCGGCCTCAGCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.169395616505062					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674076	27674126	27632585	27632635	12047	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-22				TGTCTAGAGGACTTATATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36041296561338437					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674677	27674727	27633186	27633236	12048	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-23				CACGGCCCCGCAGAAGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40356306877281772					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674257	27674307	27632766	27632816	12049	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-24				CCGACGGCAGCCGGCCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6105913699547354					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674743	27674793	27633252	27633302	12050	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-25				GATAGAAAACCGGGCCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18227463785024811					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674541	27674591	27633050	27633100	12051	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-26				AGACCGCGCAGGGCCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6686240298163519					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674502	27674552	27633011	27633061	12052	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-27				GCTGCTGCAGGGCCTAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2478006701975991					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674122	27674172	27632631	27632681	12053	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-28				TCATTTTATTTCTAGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91085175336222213					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674513	27674563	27633022	27633072	12054	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-29				CTCGTCCGCCTGCTGCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33544150112194					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674147	27674197	27632656	27632706	12055	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-3				ACTCCAGCTTCCATTACGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53773611008753652					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674565	27674615	27633074	27633124	12056	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-30				AGCTGGGCGGTGAGTGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5516653947113983					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674565	27674615	27633074	27633124	12057	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-30				AGCTGGGCGGTGAGTGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5516653947113983					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674554	27674604	27633063	27633113	12058	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-31				CACCGCCCAGCTCCCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15172028166649371					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674785	27674835	27633294	27633344	12059	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-32				TCAGGAGCTGCAGCTCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37190976280176852					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674659	27674709	27633168	27633218	12060	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-33				GGCTCAGGAAAGACTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074534134976871683					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674644	27674694	27633153	27633203	12061	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-34				GGAGAAGTTGGACAGGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38799784745387789					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674767	27674817	27633276	27633326	12062	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-35				TGAGGAGAAGATGGAAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1366784519030919					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674868	27674918	27633377	27633427	12063	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-36				TCCTGGAGGGTGAGCTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0103742263875135					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674314	27674364	27632823	27632873	12064	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-37				AGGCTTGGGGGGCCAGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.000739221460603					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674711	27674761	27633220	27633270	12065	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-38				GCTGCAGATGAGAGTGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.085938322879620679					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674212	27674262	27632721	27632771	12066	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-4				ACCGCCGACGTCAGCACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053939338149031638					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674288	27674338	27632797	27632847	12067	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-43				GGCGGGGGCGGCCCCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.413176435230369					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674351	27674401	27632860	27632910	12068	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-44				GGCTGGGCTCGGCTGGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25602394297838249					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674271	27674321	27632780	27632830	12069	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-45				CCCGGGGGGCGGGGAGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7253454174786169					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674842	27674892	27633351	27633401	12070	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-5				CTGGGAGGTAGCTCGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42903121482031159					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674239	27674289	27632748	27632798	12071	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-6				GTCGGGGCGATGAGGTCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31722597389107959					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674827	27674877	27633336	27633386	12072	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-7				GGCTGACCGCAAATACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34477101420141121					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674332	27674382	27632841	27632891	12073	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-8				CGCGGCAGTGCAGCTCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44265312798280582					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674582	27674632	27633091	27633141	12074	hg38	N/A	enh54045	N/A	Enhatls121111	enhancer	EOMESe-6-9				GAGCGGCGCGAGAAAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51382029139079255					EOMES	chr3	27715948	27722711	82833				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27674582	27674632	27633091	27633141	12075	hg38	N/A	enh54045	fant11544	Enhatls121111	enhancer	EOMESe-6-9				GAGCGGCGCGAGAAAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51382029139079255					EOMES	chr3	27715948	27722711	82470				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631683	27631733	27590192	27590242	12076	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-1				GCCAAAGAATGAACACTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56784011151713842					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631583	27631633	27590092	27590142	12077	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-10				CCTGAGCAAAGGAGGTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17488820755848811					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631188	27631238	27589697	27589747	12078	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-11				TGGAAACATTCAAAATCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1549931342338871					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631421	27631471	27589930	27589980	12079	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-12				ACTATGGGCTAGGAAGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0367964773271776					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631219	27631269	27589728	27589778	12080	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-13				TCGCTGGGATTACCAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15400299107717691					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631337	27631387	27589846	27589896	12081	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-14				TAGTGCTCTATAGAACTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.497212510141898					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631446	27631496	27589955	27590005	12082	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-15				ACAGAAATAGAGTAGAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.075419307158908613					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631609	27631659	27590118	27590168	12083	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-16				GGAAGGGAAAGCAAAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.243563551489642					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631372	27631422	27589881	27589931	12084	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-17				ATACAAAAGGACAGATAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.475871484092812					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631488	27631538	27589997	27590047	12085	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-18				CTAATGTTCTCACTCATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30251452316515981					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631168	27631218	27589677	27589727	12086	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-19				CATTTATCATTTCTTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.1284989360102058					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631385	27631435	27589894	27589944	12087	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-2				GATTGGATACGGAATACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44211354125590357					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631572	27631622	27590081	27590131	12088	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-3				GGAGATTTCCTCCTGAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89687236384884694					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631207	27631257	27589716	27589766	12089	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-4				CAGGGTGCCATACCTCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29387804326112171					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631234	27631284	27589743	27589793	12090	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-5				TAGAGCTTCGTTCTGTCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23407214229433651					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631515	27631565	27590024	27590074	12091	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-6				AAAGCATGCAGTAACAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43221138068863668					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631396	27631446	27589905	27589955	12092	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-7				TGGGAGATAGAGATTGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0026166925987499128					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631546	27631596	27590055	27590105	12093	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-8				TCTATCTCTTTGCTCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34370774305707807					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27631560	27631610	27590069	27590119	12094	hg38	N/A	enh35283	N/A	Enhatls121111	enhancer	EOMESe-7-9				AGGAAATCTCCTCTCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00877263718645268					SLC4A7	chr3	27372720	27484420	103435				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575513	27575563	27534022	27534072	12095	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-1				AGCAGAGCCCCATTCCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24781605544678389					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575448	27575498	27533957	27534007	12096	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-10				GAGTTTACTGGGTTAGTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16592612918483829					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575494	27575544	27534003	27534053	12097	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-11				TGCTGAGGTGGCTGCGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035851281376881462					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575474	27575524	27533983	27534033	12098	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-12				AGGGATGTGTCACCGACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.435024626771432					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575705	27575755	27534214	27534264	12099	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-13				CGCTTTTTAGTTGTTACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16250467250473091					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575274	27575324	27533783	27533833	12100	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-14				TGTGATTTTAATTAGCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71196834408825216					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575136	27575186	27533645	27533695	12101	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-15				TTCAGTAAAGCCCTAAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32701279369332942					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575366	27575416	27533875	27533925	12102	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-16				CTGACTCACACAGGATACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24285372322507129					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575839	27575889	27534348	27534398	12103	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-17				TAACGTTTATAAATAACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-8.3592320325819731					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575672	27575722	27534181	27534231	12104	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-18				GTCACCACCTTTCCTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043267938624629167					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575761	27575811	27534270	27534320	12105	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-19				ACACCTGGACATTATTCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85874317492779029					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575381	27575431	27533890	27533940	12106	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-2				TACATCGGATTTTCTCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019037907165272271					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575542	27575592	27534051	27534101	12107	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-20				CAGCTTGGCCTCCTGGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4053603260809307					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575236	27575286	27533745	27533795	12108	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-21				TGTGGCCTTTCATCTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2993182375856987					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575605	27575655	27534114	27534164	12109	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-22				TCAAAATCTCCCTGGTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1163656693107641					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575527	27575577	27534036	27534086	12110	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-23				CCGTGCAGGAAGAGCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57818571979354072					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575553	27575603	27534062	27534112	12111	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-24				CAAACAACATTCCCATCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63627537199331308					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575219	27575269	27533728	27533778	12112	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-25				ATGTGGATTTTCTGTCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.312350663566629					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575292	27575342	27533801	27533851	12113	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-26				TCACAATTAAAACAAGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4479535323027129					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575116	27575166	27533625	27533675	12114	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-27				GAACTTTAAATATAAACTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575636	27575686	27534145	27534195	12115	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-28				ATTAGTGGGTGTTTGTTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25807090221748058					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575850	27575900	27534359	27534409	12116	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-29				AATAACAGTGGGAAAGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3025853844481392					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575741	27575791	27534250	27534300	12117	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-3				TGTCCGCTTTTAAGCATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.018953741018077071					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575396	27575446	27533905	27533955	12118	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-30				GCTTTTTTCCAAATGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96672770324742252					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575147	27575197	27533656	27533706	12119	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-31				ACCTTTTCTTTCCAAAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03089156530091007					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575304	27575354	27533813	27533863	12120	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-32				CAAGCAGAGGGGATGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.208970063134198					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575861	27575911	27534370	27534420	12121	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-33				GAAAGAGGAAGGTGGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0853156099765036					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575200	27575250	27533709	27533759	12122	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-4				GTGGTCCTTGATTGGCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4801283008928387					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575347	27575397	27533856	27533906	12123	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-5				TCAGTTGTGAGTGTATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32478049371484369					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575621	27575671	27534130	27534180	12124	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-6				TCCAGGGTGTGAGTCATTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88992562662695962					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575259	27575309	27533768	27533818	12125	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-7				CACGCAGGTCATCTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20951292595814849					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575462	27575512	27533971	27534021	12126	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-8				AGTAAACTCCATCCCTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21155945947195351					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113184	chr3	27575689	27575739	27534198	27534248	12127	hg38	N/A	enh20434	N/A	Enhatls121111	enhancer	EOMESe-8-9				TGTTGGTCTTCTCAATCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.406342136147343					SLC4A7	chr3	27372720	27484420	44915				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1313
enhrx-113159	chr3	27399323	27399373	27357832	27357882	12128	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-1				GTCATGGAGTTGTCAATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24393124350876169					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399204	27399254	27357713	27357763	12129	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-10				ACTTTAATAATCCAGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36350439699376108					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399429	27399479	27357938	27357988	12130	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-11				CAAAGCAATCTTACTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065534016282863414					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399510	27399560	27358019	27358069	12131	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-12				AATAAGTGTTAGAGAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31604937248099479					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399348	27399398	27357857	27357907	12132	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-13				GCCTCACTCTCGCCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094124283390024613					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399459	27399509	27357968	27358018	12133	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-14				ATACAGTTTCATTAGAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65839285700730465					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399146	27399196	27357655	27357705	12134	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-15				TTTCTGTCTTTATCTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1698388309847956					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399367	27399417	27357876	27357926	12135	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-16				AGGCTGGGAAAGGAGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71358344367890836					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399294	27399344	27357803	27357853	12136	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-2				CCCTAAGTACAGAGTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72177365087542011					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399391	27399441	27357900	27357950	12137	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-3				CAAGCAGTTAAAGCTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51982882574556033					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399193	27399243	27357702	27357752	12138	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-4				TCACCTGAATACCACTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42249952418026238					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399170	27399220	27357679	27357729	12139	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-5				TATTCAGACTGGTGTGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1150606283035235					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399336	27399386	27357845	27357895	12140	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-6				ACTCCATGACAACCAGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1390706872954719					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399181	27399231	27357690	27357740	12141	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-7				TATTCAGGTGATATTCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1622142161031925					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399527	27399577	27358036	27358086	12142	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-8				CTTATTCTACCAATGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62442976919640814					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113159	chr3	27399264	27399314	27357773	27357823	12143	hg38	N/A	enh54044	N/A	Enhatls121084	enhancer	EOMESe-9-9				TCTCAATTAGAGATTCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.87427388277542					NEK10	chr3	27106483	27369460	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1288
enhrx-113188	chr3	27770243	27770293	27728752	27728802	12144	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-1				GGTTAAACGCCTGACCACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.8457987244481719					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770437	27770487	27728946	27728996	12145	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-10				ACCGCAGAGAGCGGCTGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0043571111160192					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770048	27770098	27728557	27728607	12146	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-11				GCACTTCAAAGCGAGGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7817505932743316					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770143	27770193	27728652	27728702	12147	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-12				AGTATCTCCCGCCACCCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7304872597382932					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769863	27769913	27728372	27728422	12148	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-13				CCGGGGATTCCCAGTCCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6063560086844788					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770349	27770399	27728858	27728908	12149	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-14				CATCTGGATCCACTCGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7805682641564813					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770006	27770056	27728515	27728565	12150	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-15				GGGGAAATCAAGTGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7312818300295891					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770484	27770534	27728993	27729043	12151	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-16				TTAAGCAGCCCAGGCCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.083463453664919					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770098	27770148	27728607	27728657	12152	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-17				TGCTAATGGCCGCCTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7201798916915116					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770257	27770307	27728766	27728816	12153	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-18				CTACTCACTTAACTCCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.66941561634372					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770449	27770499	27728958	27729008	12154	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-19				GGCTGTCGAGGGAAGTCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.775866647337506					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770172	27770222	27728681	27728731	12155	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-2				TGACAAGTAATCGGCCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.09099557106197					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770546	27770596	27729055	27729105	12156	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-20				GGCTCCTTGATATTCTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.8007296419491707					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770374	27770424	27728883	27728933	12157	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-21				ATGCCGCCACTGAGGCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.285544959342694					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770461	27770511	27728970	27729020	12158	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-22				AAGTCCGGAGGAGGCCCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.2572053241113164					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769846	27769896	27728355	27728405	12159	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-23				CCTTAGTCTTTTTCCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.117452440984584					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770021	27770071	27728530	27728580	12160	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-24				CTCCAGCCGAGCTCACCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6447608322460274					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770075	27770125	27728584	27728634	12161	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-25				CGGAAGGCACAGCCTGGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7511918568600464					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770307	27770357	27728816	27728866	12162	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-26				CAGTTAAGGGTGCCTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0495091364341063					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770131	27770181	27728640	27728690	12163	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-27				CGGGAGATACTGGAGGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1747944204687073					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770063	27770113	27728572	27728622	12164	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-28				GCGGCTGGGGCGCCCTAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9776044250363274					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769814	27769864	27728323	27728373	12165	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-29				TAAGATACTGGAGCTAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.1155163555124963					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770502	27770552	27729011	27729061	12166	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-3				CTTAATCACTCGGTAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6052907731166943					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770521	27770571	27729030	27729080	12167	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-30				GGGAGTTCCAGGGACCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.5598625878394952					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770333	27770383	27728842	27728892	12168	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-31				GTCCAGAAAAAGAGGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3933219576164584					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769956	27770006	27728465	27728515	12169	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-32				GAGTAACTGGGGACTCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.8361968811679512					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769987	27770037	27728496	27728546	12170	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-33				CTTCTTTATTTCCCCGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.542967621383547					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769969	27770019	27728478	27728528	12171	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-34				AGAAGAGCTGCTAGAGTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9448235777670151					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769878	27769928	27728387	27728437	12172	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-35				TTGCTCCTGGCCTCCCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5739722418933928					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770321	27770371	27728830	27728880	12173	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-36				TTTTTCTGGACATCCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6437338269741408					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769917	27769967	27728426	27728476	12174	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-37				GTGAACCAGGGGTAGGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.194595812026324					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770222	27770272	27728731	27728781	12175	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-38				GCTTTTGTTCTCCACCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0629815914036964					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769891	27769941	27728400	27728450	12176	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-39				GCTTTTGACCTGTTTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27962718824854638					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770388	27770438	27728897	27728947	12177	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-4				TGGCGGCATCTGCAAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7936407627523936					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770115	27770165	27728624	27728674	12178	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-40				TTAGCATTCTGTTTTTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50409044417032589					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770086	27770136	27728595	27728645	12179	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-41				CTGTGCCTTCCGCCCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7416599122437457					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770532	27770582	27729041	27729091	12180	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-42				CTGTGGGGGGAGGGAGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5255655722509236					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770187	27770237	27728696	27728746	12181	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-43				ACTTGTCAAAGAAAGAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6663464628251692					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770157	27770207	27728666	27728716	12182	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-5				CGGAACGGCAAAATCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4066736712678587					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770569	27770619	27729078	27729128	12183	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-6				ATAGTAAAGGCGTATCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6561575863072822					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770275	27770325	27728784	27728834	12184	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-7				AGTAGTCGGAAGCCTCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.277560637398					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27770289	27770339	27728798	27728848	12185	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-8				TCCCGCAGGGTTCTCGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.5768566092893641					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27769905	27769955	27728414	27728464	12186	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+1-9				GTCAAAAGCAACGTGAACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.98159555998521					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947187	27947237	27905696	27905746	12187	hg38	N/A	enh107920	N/A	Enhatls121115	enhancer	EOMESe+10-1				GAATGCCATAGCCCAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17886088572600131					EOMES	chr3	27715948	27722711	175764				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947187	27947237	27905696	27905746	12188	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-1				GAATGCCATAGCCCAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17886088572600131					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947162	27947212	27905671	27905721	12189	hg38	N/A	enh107920	N/A	Enhatls121115	enhancer	EOMESe+10-10				CTGGGATGCATGCCCTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.088538692751773451					EOMES	chr3	27715948	27722711	175764				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947162	27947212	27905671	27905721	12190	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-10				CTGGGATGCATGCCCTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.088538692751773451					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947263	27947313	27905772	27905822	12191	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-11				TCTAGAGAATTGCCCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25720990613623312					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947312	27947362	27905821	27905871	12192	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-12				TGTGGGTTGCCTCCTAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06772751141827274					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947289	27947339	27905798	27905848	12193	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-13				CAGTTTGCATTAGTTCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15841910963125061					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947493	27947543	27906002	27906052	12194	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-14				GGGAACGGGGGAAGCAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26410493984274691					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947209	27947259	27905718	27905768	12195	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-15				ATACTCATAGCAGCTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5927609610029441					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947451	27947501	27905960	27906010	12196	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-16				CAAAGATGTGGTCTCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3766540332592494					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947410	27947460	27905919	27905969	12197	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-17				TCATATTCCACAGCTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7976266176335598					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947144	27947194	27905653	27905703	12198	hg38	N/A	enh107920	N/A	Enhatls121115	enhancer	EOMESe+10-18				AAAAAATCAGAGACAGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24145316944726949					EOMES	chr3	27715948	27722711	175764				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947463	27947513	27905972	27906022	12199	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-19				GAAGAAGCTAAGCAAAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83820414941824639					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947222	27947272	27905731	27905781	12200	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-2				CTATGAGTATTGACTCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.164483256515415					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947300	27947350	27905809	27905859	12201	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-3				TAATGCAAACTGCCTCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14291201171246529					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947274	27947324	27905783	27905833	12202	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-4				GCCCTCAGCTGGGGACCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30286997882095867					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947175	27947225	27905684	27905734	12203	hg38	N/A	enh107920	N/A	Enhatls121115	enhancer	EOMESe+10-5				CCTACCAAGGTCCCCTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70245263113428391					EOMES	chr3	27715948	27722711	175764				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947175	27947225	27905684	27905734	12204	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-5				CCTACCAAGGTCCCCTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70245263113428391					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947336	27947386	27905845	27905895	12205	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-6				ACCACAGTTAACTCATATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.236369900417767					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947426	27947476	27905935	27905985	12206	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-7				AGGCCTCAATCAGATGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49066120267298119					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947379	27947429	27905888	27905938	12207	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-8				ACATAGTGTGTCTCACCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.661970452185279					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27947364	27947414	27905873	27905923	12208	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+10-9				AAGGCAGACCGCTTGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76174770471027486					EOMES	chr3	27715948	27722711	182994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984859	27984909	27943368	27943418	12209	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-1				GATTTAGGAGTCGTTTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01181824341795382					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984883	27984933	27943392	27943442	12210	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-10				TATAGGAGCAGGCTCTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32316849098971412					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984604	27984654	27943113	27943163	12211	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-11				TTCTGCCTCTAAATCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.426511989906548					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984640	27984690	27943149	27943199	12212	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-12				TGCTGTTGGCTCTTCATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0029896288314109651					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984758	27984808	27943267	27943317	12213	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-13				GTGGGGACTTCTTATTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15282829240579551					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984758	27984808	27943267	27943317	12214	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-13				GTGGGGACTTCTTATTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15282829240579551					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984822	27984872	27943331	27943381	12215	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-14				TATTATAGCAGCAGCTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7386015781598512					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984774	27984824	27943283	27943333	12216	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-15				GCCACTGCAGCTGAGACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1039678402071538					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984658	27984708	27943167	27943217	12217	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-16				TTTGGTTTTAGGTACAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37480204186663207					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984626	27984676	27943135	27943185	12218	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-17				AGTGTGCCAGATGCTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14218346286217551					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984912	27984962	27943421	27943471	12219	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-18				TTAGATGCCTATAAAATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0641925348046594					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984705	27984755	27943214	27943264	12220	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-19				CAAAGGTGGGGATGAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14010430374800259					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984740	27984790	27943249	27943299	12221	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-2				GACATTTGGGCTGGAACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.081640843569989741					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984740	27984790	27943249	27943299	12222	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-2				GACATTTGGGCTGGAACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.081640843569989741					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984951	27985001	27943460	27943510	12223	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-20				CTGTAAATATTTTAAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66096489206054243					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984805	27984855	27943314	27943364	12224	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-3				ATAATACATCTGCCACCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17751419688245049					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984687	27984737	27943196	27943246	12225	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-4				GAGGTCTAAAGTAACATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.593080770265989					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984844	27984894	27943353	27943403	12226	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-5				GACCAGTTCTGTGATGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36789399120171967					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984717	27984767	27943226	27943276	12227	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-6				TCCTGACAACCACAAAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70729590621948346					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984793	27984843	27943302	27943352	12228	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-7				TGGCGTGTTCTTCCTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074124825910309014					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984895	27984945	27943404	27943454	12229	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+11-8				CTGCTCCTATAGAATTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1231606974779321					EOMES	chr3	27715948	27722711	220570				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27984590	27984640	27943099	27943149	12230	hg38	N/A	N/A	fant11549	Enhatls121115	enhancer	EOMESe+11-9				CCCATTAATGCATTCCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14051910854231239					EOMES	chr3	27715948	27722711	220282				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027934	28027984	27986443	27986493	12231	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-1				GGTTAAAGGCTGCTGACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.468597355266975					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027768	28027818	27986277	27986327	12232	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-10				TGTAAGTAGGCCAAAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93812220908656685					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028002	28028052	27986511	27986561	12233	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-11				TGTCCCCAAGGTTTCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41679798789740208					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027985	28028035	27986494	27986544	12234	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-12				TCTGGGATGAATTGATTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19396724347102889					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027781	28027831	27986290	27986340	12235	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-13				GTTTTCACCTTAATGTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.989636618563226					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028132	28028182	27986641	27986691	12236	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-14				TGTGTTTAAGCAGTCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096287174994994909					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027973	28028023	27986482	27986532	12237	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-15				TGATTTGCTGGCCAGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.463045545793391					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028104	28028154	27986613	27986663	12238	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-16				GTTGCTTTGGGTCTTTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27671364198870479					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028117	28028167	27986626	27986676	12239	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-17				TGAGATGGTCTTTGTTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71042783841354362					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028022	28028072	27986531	27986581	12240	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-18				ACAAAAATTCACACACCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25494920835213569					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027962	28028012	27986471	27986521	12241	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-19				GAGGAATTCAGCCTCATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1128535936629525					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027719	28027769	27986228	27986278	12242	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-2				AGTTGCCCGCTTAAAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.041102837185568862					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028078	28028128	27986587	27986637	12243	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-20				GTATTATTATTCCAAATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1739147604876008					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027743	28027793	27986252	27986302	12244	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-21				AGTAGACTTTAATAAAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92995910888187383					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027857	28027907	27986366	27986416	12245	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-22				CTTCCCTCCCAGCCCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41737719795409128					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027891	28027941	27986400	27986450	12246	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-3				AGTATGCAGATGAGGCGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.267942090094254					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027827	28027877	27986336	27986386	12247	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-4				CATTGCTAATGCAAGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40063300179770989					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028067	28028117	27986576	27986626	12248	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-5				AAGACTGGCTTCCAACAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1632542942582656					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027948	28027998	27986457	27986507	12249	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-6				GAATTCCTCCATCAGGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1245604600500667					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28027845	28027895	27986354	27986404	12250	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-7				CAATGGCCACTGCCAAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18352415173746109					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028052	28028102	27986561	27986611	12251	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-8				AACCTTACCTCCTGCAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.258646055402114					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28028037	28028087	27986546	27986596	12252	hg38	N/A	enh70524	N/A	Enhatls121115	enhancer	EOMESe+12-9				GTAAGGTTTTGAATTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05832072685712749					CMC1	chr3	28241617	28325142	253596				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101071	28101121	28059580	28059630	12253	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-1				GACCCTCCGAGCCAGGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.522730866963567					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28100984	28101034	28059493	28059543	12254	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-11				TGGACGGCACCTGGAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39680313908031739					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101180	28101230	28059689	28059739	12255	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-14				GCCATTGCCCAGGCTTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027932992949111269					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101120	28101170	28059629	28059679	12256	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-2				TTGATCTCAGACTGCTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29841835731324989					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101083	28101133	28059592	28059642	12257	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-23				CTCGGAGGGTCCTACGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60911825857684809					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101196	28101246	28059705	28059755	12258	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-24				GATTAGGTAAACAAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064736082106471471					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101034	28101084	28059543	28059593	12259	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-4				GCGCCTTGTTTTAAGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22169110971361811					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101013	28101063	28059522	28059572	12260	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-5				GGAAAAGCGCAGTATTCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67985054081280594					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101100	28101150	28059609	28059659	12261	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-6				TGGCAATCAGCGAGACTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88794013948680783					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101060	28101110	28059569	28059619	12262	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-7				ACGAGATTATACCCCGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30350120942837622					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101379	28101429	28059888	28059938	12263	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-8				TCAGATCTCCAGCTGAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058922031181588043					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28101445	28101495	28059954	28060004	12264	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+13-9				CCCCGAGCAACCTAACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.576597035725916					CMC1	chr3	28241617	28325142	167384				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119220	28119270	28077729	28077779	12265	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-1				AGCAATACGGCCCCGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53866740297537918					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119390	28119440	28077899	28077949	12266	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-10				GCAGGTTCAAGTCTTGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.086928014299108874					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119293	28119343	28077802	28077852	12267	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-11				AATGGAACAGCAGGGGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79799525344721589					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119273	28119323	28077782	28077832	12268	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-12				ATTATATTGAACTTGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7021919198897311					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119133	28119183	28077642	28077692	12269	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-13				AATTCAGCTTTGTGGAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34646803273937582					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119378	28119428	28077887	28077937	12270	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-14				CTTGCTCTGGGTGTAATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37944865056040827					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119164	28119214	28077673	28077723	12271	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-15				TGAGAACAGCATGCCAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05032944213093437					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119177	28119227	28077686	28077736	12272	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-16				AGGGAGGGAGCTCCCCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31046475208911661					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119208	28119258	28077717	28077767	12273	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-17				TCCTGACACCAGCCCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.400881827745065					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119260	28119310	28077769	28077819	12274	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-2				TGTAAGCAGGACGCTCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30385636458150639					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119233	28119283	28077742	28077792	12275	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-3				CCGTATTGCTGTGGTAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56978967395573477					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119431	28119481	28077940	28077990	12276	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-4				ACGCTAAGTCTTGTCCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50028137339292855					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119412	28119462	28077921	28077971	12277	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-5				GCGTGTGTTGCTGCTGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15742995169944221					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119343	28119393	28077852	28077902	12278	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-6				AGCCTATTACTCTATGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3164472139809931					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119110	28119160	28077619	28077669	12279	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-7				AGCCCGCCTCTCAGTCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097345206996468869					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119075	28119125	28077584	28077634	12280	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-8				TATTGTCTGACAGTAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52320748151932528					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28119196	28119246	28077705	28077755	12281	hg38	N/A	enh54046	N/A	Enhatls121115	enhancer	EOMESe+14-9				TGGTGTCAGGATAAGTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40469906129892058					CMC1	chr3	28241617	28325142	162994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159835	28159885	28118344	28118394	12282	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-1				CTCACACCGAGACTCTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054739995442212558					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159627	28159677	28118136	28118186	12283	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-10				CAGACTTTCTTGAAAAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62501038033266842					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159678	28159728	28118187	28118237	12284	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-11				ACTAAGGTAAATAAACTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8252409095380939					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159910	28159960	28118419	28118469	12285	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-12				ATCTTAGTAATTTTCTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3508905855549864					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159716	28159766	28118225	28118275	12286	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-13				ACACTCTTAAAAATGTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33433358604075147					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159862	28159912	28118371	28118421	12287	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-14				TGAAGAAGTGACTGTGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01072169869919103					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159732	28159782	28118241	28118291	12288	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-15				AAAGGGAAGTGAGTGGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73027818135544775					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159662	28159712	28118171	28118221	12289	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-16				GAGGAGCTCAAACTACACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21908657846484331					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159474	28159524	28117983	28118033	12290	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-17				ATGGAGCTTATATTCTAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47359785228717138					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159531	28159581	28118040	28118090	12291	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-2				TCAGCATATTCTAGCCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87222127916458347					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159814	28159864	28118323	28118373	12292	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-3				AGTTGGTGCTGGAACTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2995096706487142					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159508	28159558	28118017	28118067	12293	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-4				TTACAGCAGTGACTATGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36505443013332178					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159785	28159835	28118294	28118344	12294	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-5				GGAACTCAGCTGTAAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.069522562774722449					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159493	28159543	28118002	28118052	12295	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-6				TGTCCAGGTCTGTGATCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13407986993158591					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159643	28159693	28118152	28118202	12296	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-7				GTTCTGGGCTAAGATGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2441866373028298					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159894	28159944	28118403	28118453	12297	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-8				CTAAAGGAATGAACTGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61152793955592233					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28159750	28159800	28118259	28118309	12298	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+15-9				GTTTTGCATCTCAAAGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059120912508088833					CMC1	chr3	28241617	28325142	108564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241848	28241898	28200357	28200407	12299	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-1				GATCCCCCACCGGGGCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53256957616988387					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241719	28241769	28200228	28200278	12300	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-10				AGGGTTTGTGAATGCACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84861424574472033					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241991	28242041	28200500	28200550	12301	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-11				GAGCCTCCTACCCCCTCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066086411699713063					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241883	28241933	28200392	28200442	12302	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-12				GCGGGCGCACGGCGCAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.456076154026021					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242263	28242313	28200772	28200822	12303	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-13				AGAGGCGTGAGCGGGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.60676581237947					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242422	28242472	28200931	28200981	12304	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-14				AAGAGCAAGCGAGGGCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26725962677229309					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242089	28242139	28200598	28200648	12305	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-15				CGCCGGTGGGCTGGTACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.222946719968994					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242076	28242126	28200585	28200635	12306	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-16				AAGTCGAGCGCAGCGCCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0039197040832239091					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242119	28242169	28200628	28200678	12307	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-17				AGTACACCGTCCGCAGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16820568769940111					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241899	28241949	28200408	28200458	12308	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-18				CGCCCGCATTCCTCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0975128229895408					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242326	28242376	28200835	28200885	12309	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-19				GCCCGTTTCTGGGCTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29431598280163768					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242242	28242292	28200751	28200801	12310	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-2				GGCTGCGCGCTGGCGCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47058406617887388					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242044	28242094	28200553	28200603	12311	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-20				GCCCGGCGGGAAGGCAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62064957003439269					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242377	28242427	28200886	28200936	12312	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-21				CTTCTCAAGTGCCGCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5021780360972935					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242181	28242231	28200690	28200740	12313	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-22				CCGGCTGGCGGCTCCGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8687261542990603					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242404	28242454	28200913	28200963	12314	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-23				CTCTTGGCGCCTCCTCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069367238991825939					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241826	28241876	28200335	28200385	12315	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-24				GCCCAGCTGGCTTCACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89312591575204991					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241733	28241783	28200242	28200292	12316	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-25				ACAAACCCTAAGCTAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32771380943270839					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242143	28242193	28200652	28200702	12317	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-26				ACAATAAGGGGCTTAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01197503687389107					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242337	28242387	28200846	28200896	12318	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-27				GCACTGTGGGAGCCCGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32163645206140939					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241949	28241999	28200458	28200508	12319	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-28				GCAGGGGGCGGCGCTCATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.299290181795159					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242194	28242244	28200703	28200753	12320	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-29				GGCTTGGCGGGTCCCGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0833114670677171					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242458	28242508	28200967	28201017	12321	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-3				TGTCAACTCTCAGTTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81814197033115255					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242003	28242053	28200512	28200562	12322	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-30				GTAGGAGGCTCAGGCATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.09489053591973011					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242295	28242345	28200804	28200854	12323	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-32				GGCTCCCTCAGCTTGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25910893702887922					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242281	28242331	28200790	28200840	12324	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-33				GCAGGGAGGTGTGGAGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2334147357098271					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242353	28242403	28200862	28200912	12325	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-35				ACAGTGCAGCGGTGGGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.043439590124310153					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241934	28241984	28200443	28200493	12326	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-36				ACTGGGCGCCGTGGAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.210527880038417					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242222	28242272	28200731	28200781	12327	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-37				GGGCCAGCTGGAGTTCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.569816670309391					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241910	28241960	28200419	28200469	12328	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-38				CTCAGCCCTTGGGTGGTCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5331989529435156					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242391	28242441	28200900	28200950	12329	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-39				CTCTGCCTGGGCTCCCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15673940793678631					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241786	28241836	28200295	28200345	12330	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-4				ACGTGGAGAACCTTTATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21054658072131591					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242207	28242257	28200716	28200766	12331	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-41				CCGCCAAGCCCACGCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63643481121534407					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242309	28242359	28200818	28200868	12332	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-42				GAGGGAGCCGGCTCCGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2345860974517778					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241966	28242016	28200475	28200525	12333	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-5				TCGGGGACGCTCCGCCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42686856730485151					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28241977	28242027	28200486	28200536	12334	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-6				CTCCGTGGGCTCCTGTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47259290373499208					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242169	28242219	28200678	28200728	12335	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-7				GGGCCGGCAGGGCCGGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20283998200118669					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242027	28242077	28200536	28200586	12336	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-8				TGCAGGTCCCGAGCCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15785057561901261					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	28242155	28242205	28200664	28200714	12337	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+16-9				TGCCGGCCCCGGACAATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15243000848797161					CMC1	chr3	28241617	28325142	32564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113213	chr3	28647797	28647847	28606306	28606356	12338	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-1				ATAGGAGTCTATAGTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41451002076323912					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647904	28647954	28606413	28606463	12339	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-10				AGCAAAGGATTCCATTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089804883584681319					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647920	28647970	28606429	28606479	12340	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-11				AGGACAGACACAATTACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75394927543413426					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647811	28647861	28606320	28606370	12341	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-12				TGAAGCAGGGTGGTGTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17796866998665051					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647875	28647925	28606384	28606434	12342	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-13				GAAAAGGTAAGTGCCTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055161221664640367					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28648039	28648089	28606548	28606598	12343	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-14				ATCTCTCCCTTGAAATGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6624481054943081					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647888	28647938	28606397	28606447	12344	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-15				CTTTGCTCTATTTCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1668190760067936					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647859	28647909	28606368	28606418	12345	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-16				AGTCAGGTAAACTGAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34830164004838871					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647977	28648027	28606486	28606536	12346	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-2				ATGTCAATAGGTGCCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.330972547526279					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647846	28647896	28606355	28606405	12347	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-3				TTACCTGACTATATCTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86662904528363072					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647779	28647829	28606288	28606338	12348	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-4				GTAGCTCTCAGTGAGAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1260349724639532					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647964	28648014	28606473	28606523	12349	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-5				GTCCCGGCAAACTCCAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15276933216819369					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647989	28648039	28606498	28606548	12350	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-6				GGTGTACTTGAGATGTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057388435642816718					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28648010	28648060	28606519	28606569	12351	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-7				GCAGGCTCTAGGTGGGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.597187436938227					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28648028	28648078	28606537	28606587	12352	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-8				GAAATGAAAGGGCTGACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.259372444528688					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28647948	28647998	28606457	28606507	12353	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+17-9				TCTTTGCATGCCTCATGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85982877838834448					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653604	28653654	28612113	28612163	12354	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-1				CGATGTAGCCAAGTTAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00988341835106227					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653774	28653824	28612283	28612333	12355	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-10				TTGTATCAGGATAAAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1995193856683587					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653925	28653975	28612434	28612484	12356	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-11				CAACTGTCTTTGCAACATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33846576913150439					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653636	28653686	28612145	28612195	12357	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-12				TTCAGTGTTGATAAAACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12141067466582781					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653870	28653920	28612379	28612429	12358	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-13				GCACAGTCTTTAAAATCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60134837095068761					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653731	28653781	28612240	28612290	12359	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-14				AAGAAAAGCTACAATACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35960887231862448					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653994	28654044	28612503	28612553	12360	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-15				ATTCAGCTGTTTTTTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29777179250110769					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653902	28653952	28612411	28612461	12361	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-16				ACAAAGAGTAGAGAACAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0026905717235054349					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28654072	28654122	28612581	28612631	12362	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-17				GTTTCTAAATACACAGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31231940798191482					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653797	28653847	28612306	28612356	12363	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-18				TTCATGAAAAATTTGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19876825593888861					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28654049	28654099	28612558	28612608	12364	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-19				TGTAAATCTCTTTTCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27023977621056078					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653965	28654015	28612474	28612524	12365	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-2				TTGCACAGGCAGTAATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1025821455747741					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653761	28653811	28612270	28612320	12366	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-20				TTTCCTTAAATATTTGTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.781794575285589					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28654089	28654139	28612598	28612648	12367	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-3				AGAAACTAATATCCCCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10601438496190051					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28654103	28654153	28612612	28612662	12368	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-4				GCAAATATCTGACCCCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13049862201259541					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653688	28653738	28612197	28612247	12369	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-5				AATAGATAGTTTACATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653666	28653716	28612175	28612225	12370	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-6				GTCTCCTTTCTACAGACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19244314120999689					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653979	28654029	28612488	28612538	12371	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-7				AGCTGAATTAAATATTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6323414913855715					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653833	28653883	28612342	28612392	12372	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-8				ATGCTCATGCTCTGTTCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1464240782613524					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28653715	28653765	28612224	28612274	12373	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+18-9				ACTTCTAAAAGACTATCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036426000905356762					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745491	28745541	28704000	28704050	12374	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-1				AACAAAAGCTGGGCCCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6099080198566369					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745658	28745708	28704167	28704217	12375	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-10				TCAGATCCCCTTCAGGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080473304075288729					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745502	28745552	28704011	28704061	12376	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-11				GATGTTGCAGTAACAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48204012209406522					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745605	28745655	28704114	28704164	12377	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-12				TGCAGCTATGAGCTGTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14792870718985629					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745565	28745615	28704074	28704124	12378	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-13				GTGGAGCTCCCTTTGACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20645022629332321					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745416	28745466	28703925	28703975	12379	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-14				TTGCAGTGCAATTGCAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19354443807917909					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745627	28745677	28704136	28704186	12380	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-15				GCAGCACTTCTGATAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2246577753629799					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745338	28745388	28703847	28703897	12381	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-16				TTTTTGGGGGCAGTGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34898458932280219					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745297	28745347	28703806	28703856	12382	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-17				TGCCCTGGAAACAGACGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16049774744580539					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745435	28745485	28703944	28703994	12383	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-18				GAGGCTTCAGCCAAACCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31502428518045439					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745370	28745420	28703879	28703929	12384	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-19				TATAAGAAAGTGAGGGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70273390234766653					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745273	28745323	28703782	28703832	12385	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-2				GACGGTGCTCTGTGTTAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17587713023016					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745593	28745643	28704102	28704152	12386	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-20				TCATAGCTGCACCCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23786993164276929					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745527	28745577	28704036	28704086	12387	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-21				GTCATTGGATGGGGGCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34532684556507148					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745322	28745372	28703831	28703881	12388	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-22				GAGATTTATATGTAGATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.61272963201734					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745580	28745630	28704089	28704139	12389	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-23				ACCAAGGGCAGTTCCTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063775413137986445					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745464	28745514	28703973	28704023	12390	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-3				TCCTAAAGGATCAGCCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2710122145062806					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745477	28745527	28703986	28704036	12391	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-4				TCCTTTAGGATTATCCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.25380437567929					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745545	28745595	28704054	28704104	12392	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-5				CACACTAAACCATCCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057765860822270573					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745450	28745500	28703959	28704009	12393	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-6				CCCAAGGGAAGACTCCAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0792043656061876					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745516	28745566	28704025	28704075	12394	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-7				TGCAACATCCAGTCATTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14618863317758651					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745255	28745305	28703764	28703814	12395	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-8				AACTATATCCACCATTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.312720410945642					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28745384	28745434	28703893	28703943	12396	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+19-9				GGTCACAGGATTAGGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19920273600123969					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113188	chr3	27771762	27771812	27730271	27730321	12397	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-1				GAGCGATAGTGCATCACCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.849162882482732					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771746	27771796	27730255	27730305	12398	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-10				GCGAGTGGCGAATGCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3003232520849748					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772041	27772091	27730550	27730600	12399	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-11				GGGGCGGTGATAAGATAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51715869387269309					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771662	27771712	27730171	27730221	12400	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-12				AATCCCGAAACACTCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.378512383247946					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771717	27771767	27730226	27730276	12401	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-13				CGCCTCAGAGGAGTCTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16132199113173659					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771698	27771748	27730207	27730257	12402	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-14				GGCGGAGTTGGCTGTCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9861218609767					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771854	27771904	27730363	27730413	12403	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-15				GGCGTCAGGCGCTGCAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.429720528656504					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771631	27771681	27730140	27730190	12404	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-16				CGCCGAGGTCCCGCGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4117920675004028					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771574	27771624	27730083	27730133	12405	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-17				GAAGCCTTCCAATTGAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1736698506015779					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772002	27772052	27730511	27730561	12406	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-18				AGTGCCATCCAGACTGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22433501478955231					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771884	27771934	27730393	27730443	12407	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-19				CGCCAGGAACCCAGCCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0036854324479672					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771794	27771844	27730303	27730353	12408	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-2				TTCCCGGGCTGCGCGTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0553342241560388					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772091	27772141	27730600	27730650	12409	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-20				GCTTCTGGGAAAAGATACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3833699228891509					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771676	27771726	27730185	27730235	12410	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-21				GCAAGTGCGCAGTCCCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1359627096823814					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771731	27771781	27730240	27730290	12411	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-22				CTTTTAGGGCTCTGAGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.04030422983584768					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772076	27772126	27730585	27730635	12412	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-23				ATCCATTCCAGATTGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1764465896231236					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771523	27771573	27730032	27730082	12413	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-24				AGCTAGGGTTTTTGGACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19888302386821011					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771915	27771965	27730424	27730474	12414	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-25				GCAGAGAAGGATAAGGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.354186011954631					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771599	27771649	27730108	27730158	12415	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-26				GGGAAGCGAGAAGGCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.514908055892952					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771833	27771883	27730342	27730392	12416	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-27				CCACGTAGGGGCTCAAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5122454749478846					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772062	27772112	27730571	27730621	12417	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-28				GGAATGGATGTGTATTTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0012155321840028					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771972	27772022	27730481	27730531	12418	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-29				AGCCGCCAAAGGCTGGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.34906873612062					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771902	27771952	27730411	27730461	12419	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-3				TGGCGCTTACGACGCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2292756571316252					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771870	27771920	27730379	27730429	12420	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-30				GTCAGGGAAGGCTCCCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0010271181154069					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772122	27772172	27730631	27730681	12421	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-31				GAGGGTGAGAGGAAATATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.958198057790365					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772133	27772183	27730642	27730692	12422	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-32				GACCAAAGAGGGAGGGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6864763218859471					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771615	27771665	27730124	27730174	12423	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-33				TCAGAGGAGGGAGAGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.0633000515954087					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771947	27771997	27730456	27730506	12424	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-34				AGGAGGACAAAGGAGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2188009334594718					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771821	27771871	27730330	27730380	12425	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-35				AAAAAAAAAAGTCCACGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32922865210635172					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771809	27771859	27730318	27730368	12426	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-36				CTTTTTTTTTTCTTTTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46302739609953608					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771560	27771610	27730069	27730119	12427	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-4				GAAGGCTTCAAACGTCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8158739939694613					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771508	27771558	27730017	27730067	12428	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-5				GAAAGCGCGCTCTAAAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66720785818615047					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771646	27771696	27730155	27730205	12429	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-6				CGGGATTAGGGTGTCCGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8713810943053071					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771983	27772033	27730492	27730542	12430	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-7				TTGGAGATCTAAGCCGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.362976278543123					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772145	27772195	27730654	27730704	12431	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-8				CTCGGCGTCAAGGACCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.50731555805498					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27771777	27771827	27730286	27730336	12432	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+2-9				TATCGCTCCCACCCACGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7332166462463929					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113213	chr3	28758496	28758546	28717005	28717055	12433	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-1				CTAATGACCTCTGCCAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1197538125413885					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758507	28758557	28717016	28717066	12434	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-10				AGAGGTCATTAGGCAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35079232721930309					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758308	28758358	28716817	28716867	12435	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-11				CTCAAATCAAAACAGGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039779523233162209					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758588	28758638	28717097	28717147	12436	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-12				GAAGTATATACATTACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758369	28758419	28716878	28716928	12437	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-13				AGCACAAAGATTTTTTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1018132646228489					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758536	28758586	28717045	28717095	12438	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-2				TCTCCGTGATACTACATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75035769698528643					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758473	28758523	28716982	28717032	12439	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-3				CTCTTGAAGTGCTACCTACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13965086006148891					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758348	28758398	28716857	28716907	12440	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-4				GGCCACCTCATATCCCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.066136528352406					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758430	28758480	28716939	28716989	12441	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-5				CTCTTTCAGCAGCTGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0047687627827145982					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758397	28758447	28716906	28716956	12442	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-6				CTAGACCTAGAAAATCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3768977385133539					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758565	28758615	28717074	28717124	12443	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-7				CACAAATGTAGATTGTAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18048651175121239					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758334	28758384	28716843	28716893	12444	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-8				ATGTAGGAATACTGCCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73376653742503573					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113213	chr3	28758414	28758464	28716923	28716973	12445	hg38	N/A	N/A	N/A	Enhatls121140	enhancer	EOMESe+20-9				AAGCTGGGTTAGGCTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.025479087626334721					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1342
enhrx-113215	chr3	28806795	28806845	28765304	28765354	12446	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-1				CTCAAAGCACGATCACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32409997915846489					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807025	28807075	28765534	28765584	12447	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-10				TTAATCTTCAGCTTGATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76294239649633122					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806702	28806752	28765211	28765261	12448	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-11				GATATGAACTGATGAGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00954088580066479					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807160	28807210	28765669	28765719	12449	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-12				GGTCAGTTGCCAGAAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19393023502411849					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806675	28806725	28765184	28765234	12450	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-13				GAAAGATCAGTTTTATCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089137260692603179					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806956	28807006	28765465	28765515	12451	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-14				GATCTAAGGAACATAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.657780395424556					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806842	28806892	28765351	28765401	12452	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-15				TTTAGGAATAATTCTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55846188112657569					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807010	28807060	28765519	28765569	12453	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-16				ATTAATGGCTTCAAAGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43542297136778468					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807131	28807181	28765640	28765690	12454	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-17				TGAGGAAAGGGTAGACATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74517522918675716					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807072	28807122	28765581	28765631	12455	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-18				TTCTAAAAAGACAAGTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1860603528049756					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28807143	28807193	28765652	28765702	12456	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-19				GAATGGAAACTATGAGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1434609979217277					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806742	28806792	28765251	28765301	12457	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-2				ATGGGTGATGAAATGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045377032927842072					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806942	28806992	28765451	28765501	12458	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-20				CTCTGAGAACCAATGATCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55466071860913146					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806810	28806860	28765319	28765369	12459	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-21				TGTCTTTTAACACTCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3303872647928866					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806906	28806956	28765415	28765465	12460	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-22				CTAGGTGAGACTGATGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37879751140089818					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806888	28806938	28765397	28765447	12461	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-23				TGCATGTCTGACAAGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1483629052261404					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806631	28806681	28765140	28765190	12462	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-3				AATATAAGACACCATCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13240085109859329					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806646	28806696	28765155	28765205	12463	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-4				ATCTCATGGCTTTCTCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1227995944547917					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806770	28806820	28765279	28765329	12464	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-5				TTATCAGTGGTCTAAGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059468382048765908					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806855	28806905	28765364	28765414	12465	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-6				TATTCCTAAATCAGAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67705115646866365					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806660	28806710	28765169	28765219	12466	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-7				GATCTTTCTGGTGTATCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29989156653689869					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806759	28806809	28765268	28765318	12467	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-8				GACCACTGATAAAAATTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58683304768440014					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28806723	28806773	28765232	28765282	12468	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+21-9				GGATAGAGATTTTCATCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.025422398870191161					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828112	28828162	28786621	28786671	12469	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-1				TCGTTTGTAGGCGTGTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44459383268977459					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828000	28828050	28786509	28786559	12470	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-10				AGGGGCTGAAGAGAGTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7469211324602234					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828076	28828126	28786585	28786635	12471	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-11				GAGCTTAGCATTTGAACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46821289643815223					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828039	28828089	28786548	28786598	12472	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-12				ATAGCCCTCCCGAATGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17564372110736531					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828150	28828200	28786659	28786709	12473	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-13				GTCAATTTGACTGCACCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13366934914342329					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828124	28828174	28786633	28786683	12474	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-2				CCTACAAACGAGGCTTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036148144290705592					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828192	28828242	28786701	28786751	12475	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-3				GTTATCACATCTAATAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3116664680228392					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828018	28828068	28786527	28786577	12476	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-4				GGGCATCTTCCAATCTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.318948121960597					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828205	28828255	28786714	28786764	12477	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-5				ATAGGGCAGGGAGTATTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14347662225865621					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28827957	28828007	28786466	28786516	12478	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-6				CAATCAGGTAGAAAGGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13898664942466291					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828264	28828314	28786773	28786823	12479	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-7				GTAGAGGAATCAGAGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38194711550042337					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828250	28828300	28786759	28786809	12480	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-8				TTCCTCTACTTTCTTAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.142125451635353					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28828135	28828185	28786644	28786694	12481	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+22-9				GGCTTAATCTGGGCACCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8108468130194471					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833503	28833553	28792012	28792062	12482	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-1				CACTCACTTTATAAACGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1363172909686203					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833233	28833283	28791742	28791792	12483	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-10				GCCTGGTGACACTGTCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41758959403836138					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833287	28833337	28791796	28791846	12484	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-11				TCCTAATTGTTAACAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.520009113102291					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833395	28833445	28791904	28791954	12485	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-12				ACTCATAAAAGAAAGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33279244097125432					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833265	28833315	28791774	28791824	12486	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-13				GAAAACAGGCAGAAGTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30311687592234549					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833218	28833268	28791727	28791777	12487	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-14				TCTCTTTTCTTGCTCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.129632609862074					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833424	28833474	28791933	28791983	12488	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-15				CAGCCAGCCTCTTCCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0098524740934289017					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833439	28833489	28791948	28791998	12489	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-2				CCTCCTGGTGAAATTTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31200325877235452					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833197	28833247	28791706	28791756	12490	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-3				GACTGCAATTCAGAGCAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094952997582695986					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833486	28833536	28791995	28792045	12491	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-4				GGATACAAGAGCTATGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56539345524939189					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833380	28833430	28791889	28791939	12492	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-5				TTTATCCTAGCCATTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.037662999933536237					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833470	28833520	28791979	28792029	12493	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-6				TGTATCCATGGTTGAACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13551058008345451					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833456	28833506	28791965	28792015	12494	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-7				AACAGTTGGACACATGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44649257615052779					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833250	28833300	28791759	28791809	12495	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-8				TTAGCAGGGTAAAGGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28492780783305682					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28833343	28833393	28791852	28791902	12496	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+23-9				GCATGTCAACAGAGCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42431760056054679					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947636	28947686	28906145	28906195	12497	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-1				CAAGTTCCCCGTGGTCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30743548013801952					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947434	28947484	28905943	28905993	12498	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-10				AGAAGCTCTGGTGCCATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01069541325439304					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947451	28947501	28905960	28906010	12499	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-11				TTAAAGAAACCACATGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46963360942161042					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947669	28947719	28906178	28906228	12500	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-12				AAACAACATATATTAAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.22921302197618					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947512	28947562	28906021	28906071	12501	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-13				GTAAGTAAAAGGAAATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2373610137117001					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947680	28947730	28906189	28906239	12502	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-14				ATTAAGTTGTGGAAATTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.025223159612678289					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947407	28947457	28905916	28905966	12503	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-15				CTTCCTCTGGCATCTGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1076716342974761					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947422	28947472	28905931	28905981	12504	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-16				GGTCAGGGCTCAAGAAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66642349362874342					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947501	28947551	28906010	28906060	12505	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-17				AAAGAAAAACAGTAAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60481882085613436					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947573	28947623	28906082	28906132	12506	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-2				ATTTGGAGATACCGACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2853637642960945					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947590	28947640	28906099	28906149	12507	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-3				TGACCTGTATGAACTACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36254936876679128					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947531	28947581	28906040	28906090	12508	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-4				GGAAGACCTGTTGAGATAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18074414377507461					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947562	28947612	28906071	28906121	12509	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-5				ATAATTACCTCCCTGATAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0719716135482522					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947602	28947652	28906111	28906161	12510	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-6				CATACAGGTCAATACTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52125929554008965					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947621	28947671	28906130	28906180	12511	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-7				AAGGACCTTAAAGAGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.397397445132176					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947394	28947444	28905903	28905953	12512	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-8				CTCAGCATCTTATCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074500777827463921					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	28947483	28947533	28905992	28906042	12513	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+24-9				TCTTTAGTCCCTTTATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.666616914001881					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099118	29099168	29057627	29057677	12514	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-1				ATACCTTTGTGATGCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.018603816923685991					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29098939	29098989	29057448	29057498	12515	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-10				AGCTTGCTTTCTCAACTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34883286305709521					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099007	29099057	29057516	29057566	12516	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-11				GGAATAAACTCAGTGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36665275596045788					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099335	29099385	29057844	29057894	12517	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-12				AAGTTTCTCAGGTGGTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19895101640264					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29098951	29099001	29057460	29057510	12518	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-13				CAACTAGGAGGCTTGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1147974047528123					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099191	29099241	29057700	29057750	12519	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-14				GTTGTGGCTGCTCTGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.147329468502606					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099311	29099361	29057820	29057870	12520	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-15				ATAGTCTCTTAGGAGCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.060232402532885122					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29098969	29099019	29057478	29057528	12521	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-16				CAGGGCTGTGAATTTACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051276641862599989					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099286	29099336	29057795	29057845	12522	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-17				GCCTGGGTAGCTGAAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32626213824255679					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099217	29099267	29057726	29057776	12523	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-18				GCTCAGACTCTCCCTGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.003657893558578935					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099175	29099225	29057684	29057734	12524	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-19				GGGTTGGGGGTGTGGTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2316805873654719					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099039	29099089	29057548	29057598	12525	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-2				CTGGCCTTTCAAAAGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20345518735066431					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099157	29099207	29057666	29057716	12526	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-20				GGAACATAACTCCATTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3448156704210979					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099083	29099133	29057592	29057642	12527	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-21				GGGGGAAAGCCAGCAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.098258019426130508					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099254	29099304	29057763	29057813	12528	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-22				AAGACCATCAGGTGGGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.350964625083438					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099104	29099154	29057613	29057663	12529	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-3				CAAAGGTATCCAGGGAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0684840600230576					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099020	29099070	29057529	29057579	12530	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-4				TGCTGTTGGGAGAGTAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.484652770844246					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099269	29099319	29057778	29057828	12531	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-5				ATGGTCTTTGTCTACTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.002818499573702643					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099205	29099255	29057714	29057764	12532	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-6				AGCCACAACAAACCCCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44733400218812941					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099135	29099185	29057644	29057694	12533	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-7				TGGAGGCAGCCATAATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0125148122389					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29098986	29099036	29057495	29057545	12534	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-8				GCCCTGCTCACTGGCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17470401505341829					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113215	chr3	29099067	29099117	29057576	29057626	12535	hg38	N/A	N/A	N/A	Enhatls121142	enhancer	EOMESe+25-9				TGGGAGCTAGATGAGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53508054086775569					RBMS3	chr3	28576174	30010391	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1344
enhrx-113188	chr3	27772989	27773039	27731498	27731548	12536	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-1				ATCAAAGCGGAGGACCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.019179763177372					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772944	27772994	27731453	27731503	12537	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-10				CCAGGGAGCGATCTGCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.224147086725671					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772922	27772972	27731431	27731481	12538	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-11				GCCCAAGAGCTTCTGATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1373054368034857					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773046	27773096	27731555	27731605	12539	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-12				AACCCTCTTCAGGCCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25492993282457621					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773003	27773053	27731512	27731562	12540	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-13				TGGGGCTGACGGTTCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40585316164443752					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772864	27772914	27731373	27731423	12541	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-14				TCTCAGAGGACAAACAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1174941178694679					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772877	27772927	27731386	27731436	12542	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-15				TCCTCTGAGACCCCCAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058835863504901317					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772848	27772898	27731357	27731407	12543	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-16				ATGAAGGAGTCTCAGTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8207248859913997					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772890	27772940	27731399	27731449	12544	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-17				CAGTGCTTGTTTACCTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.055847015340442					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773107	27773157	27731616	27731666	12545	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-18				TTTCAGATGGGGTCGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40099780863567858					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772962	27773012	27731471	27731521	12546	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-19				GATGGTCCCAGTGCTGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22241470635533681					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773023	27773073	27731532	27731582	12547	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-2				CAAGCAGAGCGGGATGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26247798048691567					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773119	27773169	27731628	27731678	12548	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-20				ATTCAGGAAGTGTTTCAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45168982384966577					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773034	27773084	27731543	27731593	12549	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-21				GCCCCAGCTGGCAAGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42166726125556181					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773059	27773109	27731568	27731618	12550	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-22				GAAGAGGGTTGGGCAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16773951590230471					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772978	27773028	27731487	27731537	12551	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-3				CTCCGCTTTGATCTGACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.113291898628202					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772808	27772858	27731317	27731367	12552	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-4				TTCCGCACACGCAGCGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2823768640253817					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773089	27773139	27731598	27731648	12553	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-5				TTGCTTGTTACCTAAGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75758605701175064					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772790	27772840	27731299	27731349	12554	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-6				AGGGGACGCTGCGTCTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87383949654780635					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773135	27773185	27731644	27731694	12555	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-7				ACTGGGGCCGAGGAGAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6358446528087589					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27772831	27772881	27731340	27731390	12556	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-8				AAAGGGAAACTCTCACAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.046364546101183					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27773153	27773203	27731662	27731712	12557	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+3-9				CATCTTCCAAGAGTTGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41335812955913592					EOMES	chr3	27715948	27722711	5009				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812048	27812098	27770557	27770607	12558	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-1				TCTCACGTCCTGCGTTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0552481754540139					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812253	27812303	27770762	27770812	12559	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-10				TCTGGGTGGACACATCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0049245057517054323					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812184	27812234	27770693	27770743	12560	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-11				GTCTTTCTTTCTGCCCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.91237298528132982					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811956	27812006	27770465	27770515	12561	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-12				GGAAACAACAGGTGCTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7758631919670429					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811880	27811930	27770389	27770439	12562	hg38	N/A	enh97246	N/A	Enhatls121115	enhancer	EOMESe+4-13				AACCATTGTGGAAGTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.362254026841355					EOMES	chr3	27715948	27722711	43564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811880	27811930	27770389	27770439	12563	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-13				AACCATTGTGGAAGTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.362254026841355					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811941	27811991	27770450	27770500	12564	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-14				TAGAGAGGATGTGGAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5661499691359908					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811922	27811972	27770431	27770481	12565	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-15				TAGGAACACTTTTACACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32182610550286422					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811977	27812027	27770486	27770536	12566	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-16				ATGGCAATTATTAAAAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92598547283121646					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811892	27811942	27770401	27770451	12567	hg38	N/A	enh97246	N/A	Enhatls121115	enhancer	EOMESe+4-17				GTAAACTAGTTCAACCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81673398138468267					EOMES	chr3	27715948	27722711	43564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811892	27811942	27770401	27770451	12568	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-17				GTAAACTAGTTCAACCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81673398138468267					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27811996	27812046	27770505	27770555	12569	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-18				CCATTCTAACTGGTGTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3909153305759681					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812009	27812059	27770518	27770568	12570	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-19				TGTGAGATGGTATCTCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0636524149955631					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812268	27812318	27770777	27770827	12571	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-2				CAAGGGGTCTGTGGTCCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.056050642803751709					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812286	27812336	27770795	27770845	12572	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-3				ATGCAACTCTCCATGGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49615463488823169					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812236	27812286	27770745	27770795	12573	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-4				GGAGTGATTTAAAAGGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0900931874996038					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812223	27812273	27770732	27770782	12574	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-5				AAATCACTCCTCAAGTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019713911790880379					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812198	27812248	27770707	27770757	12575	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-6				CCATTTGGGTAGAGATCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39925092419840957					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812111	27812161	27770620	27770670	12576	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-7				ATCAAGACAGATAGGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35408586905540529					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812079	27812129	27770588	27770638	12577	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-8				TAAGTGTGAAATGGAGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32200234392986637					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27812297	27812347	27770806	27770856	12578	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+4-9				GGAGAGTTGCATGGCTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52363615480962322					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863173	27863223	27821682	27821732	12579	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-1				CACGCGAATATTGCGCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27963190478564182					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863262	27863312	27821771	27821821	12580	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-10				CCCCTTGCACTTCCCAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70714018487109775					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863228	27863278	27821737	27821787	12581	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-13				CCCCTTTCTTTGACTCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17903787194265941					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863156	27863206	27821665	27821715	12582	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-28				TTTCGGACAGGCTTAAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62348989978735392					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863274	27863324	27821783	27821833	12583	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-29				GGCGAGGCATTGCCTCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44955669989740837					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863127	27863177	27821636	27821686	12584	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-3				ACAAGATTATATCCTGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0244089598190912					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863212	27863262	27821721	27821771	12585	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-4				AAAGGGGTGACGGACTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19766232004032891					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862977	27863027	27821486	27821536	12586	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-5				TGCAGCTGGGAAGCTCGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.651241970167715					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863296	27863346	27821805	27821855	12587	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-6				CACCATGCGTGAGCCGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87179076257328947					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862742	27862792	27821251	27821301	12588	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-7				CCTCCCAGTTAGGTTGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.668187478111571					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27863109	27863159	27821618	27821668	12589	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-8				GGCATAGGACCCTCCGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070154019152015065					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862999	27863049	27821508	27821558	12590	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5-9				ATTGTTTACCTAAGCAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34965219689045718					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862768	27862818	27821277	27821327	12591	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5/+13				AGAGGTCAGGGACCCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85766386947522766					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862863	27862913	27821372	27821422	12592	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5/+13				AGGGACATTTAAGTCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62395661259882806					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27862755	27862805	27821264	27821314	12593	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+5/+13				TTGCTCGGGGGTCAGAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1080916286303719					EOMES	chr3	27715948	27722711	47714				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924963	27925013	27883472	27883522	12594	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-1				GAACATACAAGGCCCCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50586489992709682					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924942	27924992	27883451	27883501	12595	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-10				TCTTTCAAGCAGATAGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027019892575151					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925001	27925051	27883510	27883560	12596	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-11				TTACTTGTCTCTCCACCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0087467007357799609					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924928	27924978	27883437	27883487	12597	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-12				AGTCTTTGGAAATACAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30704575987214522					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924909	27924959	27883418	27883468	12598	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-13				AAGGATTTGGGAAGTGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.176071132935286					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925021	27925071	27883530	27883580	12599	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-14				TAACATCAGTGTGAATTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60803421662497914					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925104	27925154	27883613	27883663	12600	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-15				TTACAGTAAATTCCTAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0448994498796109					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924861	27924911	27883370	27883420	12601	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-16				CATCACAAAAGAACTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.037265561609774282					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925052	27925102	27883561	27883611	12602	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-2				GTAATATGTGTCAAGGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55804829551852475					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924975	27925025	27883484	27883534	12603	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-3				TTGACATATAAGCCTGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92527647029654458					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925092	27925142	27883601	27883651	12604	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-4				GGTCCAATAGTGCCACATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.054926635444316717					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27925071	27925121	27883580	27883630	12605	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-5				CAGGAGTCGGCATCCTCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17704306110714491					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924986	27925036	27883495	27883545	12606	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-6				CTTATATGTCAATCTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064513135609772579					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924893	27924943	27883402	27883452	12607	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-7				TAGGTGGCTCAGTTGACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43899456345473648					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924800	27924850	27883309	27883359	12608	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-8				TATGATTGCTGGTAATGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40902917023929908					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27924811	27924861	27883320	27883370	12609	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+6-9				ACTGTTACTGTTATGATTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24307822190007339					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927233	27927283	27885742	27885792	12610	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-1				GCAGCTCCTAGGGACCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.452410586591083					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927281	27927331	27885790	27885840	12611	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-10				TGTTGGTTAAAGAGTATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6659969201491982					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927508	27927558	27886017	27886067	12612	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-11				GTTTGAAGAGGTTTTATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1145226644971569					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927136	27927186	27885645	27885695	12613	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-12				GCATCTTCAGTTTTTAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01511453324437336					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927082	27927132	27885591	27885641	12614	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-13				AGCTTGAAAATGTAATTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99240009342284					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927459	27927509	27885968	27886018	12615	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-14				GAAGAGACAAATTGTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.09652224733121835					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927520	27927570	27886029	27886079	12616	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-15				CAGGAAAAGTCTGTTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66025098470277654					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927496	27927546	27886005	27886055	12617	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-16				TTTATTCTGGGAAAATTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77635251859318144					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927434	27927484	27885943	27885993	12618	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-17				TCAGAAAACAAGCATTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0148424703165011					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927211	27927261	27885720	27885770	12619	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-2				AACCCATGCCCTCAATAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49892321308466892					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927367	27927417	27885876	27885926	12620	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-3				CACATCTTTGAGGTTAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81439781306943837					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927321	27927371	27885830	27885880	12621	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-4				TTCCAGAGCAATTGTCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32981915063306438					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927406	27927456	27885915	27885965	12622	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-5				ACTGAGGACCATTTAAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20707683207977209					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927222	27927272	27885731	27885781	12623	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-6				TCAATAATGAGGCAGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52421799472671238					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927264	27927314	27885773	27885823	12624	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-7				GTCTAGGCAGAAGCAAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32013859181633969					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927390	27927440	27885899	27885949	12625	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-8				TTAATTTCTCAGTCAAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.003511451104888836					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27927247	27927297	27885756	27885806	12626	hg38	N/A	enh48660	N/A	Enhatls121115	enhancer	EOMESe+7-9				CTAGACCAACAGCTCCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.021598322073566632					EOMES	chr3	27715948	27722711	153064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930303	27930353	27888812	27888862	12627	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-1				GCCTTATTACTAGCAAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17111495306107671					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930018	27930068	27888527	27888577	12628	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-10				TGTATGTTTGCTATATATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0826640439188819					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930092	27930142	27888601	27888651	12629	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-11				GAGATGCTGATCTCATGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066167904932085173					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930317	27930367	27888826	27888876	12630	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-12				TAATAAGGCAAGGTCTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.467131379373558					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930110	27930160	27888619	27888669	12631	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-13				ATCTCTGGAGGGAGGGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37933266491748979					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930365	27930415	27888874	27888924	12632	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-14				ATTTATGAAAATGAGGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7263051667058924					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930376	27930426	27888885	27888935	12633	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-15				ATTTTCATAAATAATGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.6064633300101541					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930182	27930232	27888691	27888741	12634	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-16				GGGGCGGAGTGAGGCAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2770144782678341					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930194	27930244	27888703	27888753	12635	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-2				CACTCCGCCCCATGGGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15261939929967369					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930281	27930331	27888790	27888840	12636	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-3				GAGTCTCTTGTGTTCCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22822706789119609					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930267	27930317	27888776	27888826	12637	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-4				AGCAGTGATCTGACCCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.248872459683194					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930399	27930449	27888908	27888958	12638	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-5				GAGTTACGAAATCACTTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13504181920373831					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930233	27930283	27888742	27888792	12639	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-6				TTATTGAACATTTGGCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44119825351786279					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930154	27930204	27888663	27888713	12640	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-7				TGTGATTTTGGTGCACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.03784455228362623					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930070	27930120	27888579	27888629	12641	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-8				GGCTAGAGCCTAGAAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0098770041480949					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930142	27930192	27888651	27888701	12642	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+8-9				ATGAGCATTCCATGTGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021160713761070461					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930852	27930902	27889361	27889411	12643	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-1				AAAGTGATGTTGTGGTTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051413762191362143					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931272	27931322	27889781	27889831	12644	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-10				TATTTAAACTACCCAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27949170312521149					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930946	27930996	27889455	27889505	12645	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-11				CATTTTCAGATCTACCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35625140712586761					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931140	27931190	27889649	27889699	12646	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-12				TCTAGCCTATCTTATTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38149089694617278					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931332	27931382	27889841	27889891	12647	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-13				TACTAACCTTGTTTTATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71179915802372906					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931187	27931237	27889696	27889746	12648	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-14				AAGACACTTAAAAAGGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.987376063703616					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931035	27931085	27889544	27889594	12649	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-15				TTATAAAAGATGCTTATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7775819151682151					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931240	27931290	27889749	27889799	12650	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-16				TAATATCATTTTGTTTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53055603974057886					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930840	27930890	27889349	27889399	12651	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-17				TGGTTCGGTGGCTGGATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.277783435374174					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931343	27931393	27889852	27889902	12652	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-18				TTTTATAAATGGCAAAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.023252416629114491					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930983	27931033	27889492	27889542	12653	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-19				AAAACAAGAAAAAAAACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30759951224242432					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930919	27930969	27889428	27889478	12654	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-2				CCTGTTGACTTTGCTCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18736074893395591					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931006	27931056	27889515	27889565	12655	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-3				CCCCAATTAGATTGCTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27243259199880232					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931320	27931370	27889829	27889879	12656	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-4				CAAGGTTAGTAATACTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.83751186333008					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931211	27931261	27889720	27889770	12657	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-5				GCTTAAGACCAGTTGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11362769309084279					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931260	27931310	27889769	27889819	12658	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-6				AGGACTAATGCACCAGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40354139021497559					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931081	27931131	27889590	27889640	12659	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-7				AACTCATCCCATTATCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41637643380377609					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27931128	27931178	27889637	27889687	12660	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-8				GATAGGCTAGAAGTTATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60365701123786131					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-113188	chr3	27930960	27931010	27889469	27889519	12661	hg38	N/A	N/A	N/A	Enhatls121115	enhancer	EOMESe+9-9				CTAAATGTAGTCATCCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46268413965000887					EOMES	chr3	27715948	27722711	165192				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1317
enhrx-76936	chr18	19774396	19774446	22194434	22194484	12662	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-1				CTGTGCTGCCTGCCGAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58838303348485355					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774396	19774446	22194434	22194484	12663	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-1				CTGTGCTGCCTGCCGAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58838303348485355					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774138	19774188	22194177	22194227	12664	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-10				AGTCATTTACTCCTTTAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54886147103681782					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774224	19774274	22194263	22194313	12665	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-12				TATCAGGGCCAGACCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6992336878345341					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774372	19774422	22194410	22194460	12666	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-13				AGAGAGCAGGGACCTCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27703873683597158					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774416	19774466	22194454	22194504	12667	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-14				AGGGAGGATGGTTGAGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72073866575227841					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774416	19774466	22194454	22194504	12668	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-14				AGGGAGGATGGTTGAGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72073866575227841					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774149	19774199	22194188	22194238	12669	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-15				GCTGGAAAACTCCCTCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0211357877207456					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774334	19774384	22194372	22194422	12670	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-16				AAGGAGGGTGGAGCAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6275312971754143					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774384	19774434	22194422	22194472	12671	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-17				AGGCAGCACAGGCCAGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.1650991636206669					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774167	19774217	22194206	22194256	12672	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-19				GACAGGCAGAGCAGCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5341630106868633					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774167	19774217	22194206	22194256	12673	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-19				GACAGGCAGAGCAGCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5341630106868633					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774071	19774121	22194110	22194160	12674	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-2				GTGGCTACTTCTCAGGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59504399698805255					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774108	19774158	22194147	22194197	12675	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-3				GAGCTTGGGCTGCTACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4661126240442313					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774191	19774241	22194230	22194280	12676	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-4				GAAAGCTGGCCGGGTTAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.33876720813447					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774191	19774241	22194230	22194280	12677	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-4				GAAAGCTGGCCGGGTTAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.33876720813447					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774205	19774255	22194244	22194294	12678	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-5				CTGGGCTTAGCACTGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.745027134403085					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774205	19774255	22194244	22194294	12679	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-5				CTGGGCTTAGCACTGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.745027134403085					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774122	19774172	22194161	22194211	12680	hg38	"hs502,hs502"	enh17588	N/A	Enhatls82552	enhancer	GATA6e-1-6				AATGACTTCAGGGAGAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1974696435596766					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774314	19774364	22194352	22194402	12681	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-7				CGGCTCTGTGTTTCCATTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.466610331203051					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774353	19774403	22194391	22194441	12682	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-8				CTCTCCCTGATCAAAGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9663630314058609					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19774239	19774289	22194278	22194328	12683	hg38	"hs502,hs502"	enh17588	fant54684	Enhatls82552	enhancer	GATA6e-1-9				GTTGAAAGAATGTGTTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.585417645562422					GATA6	chr18	22169588	22202528	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76955	chr18	20617960	20618010	23037997	23038047	12684	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-1				TGGTACGGTAACAGAACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19345751919998511					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617788	20617838	23037825	23037875	12685	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-10				TGAGTAGGGGGCTGAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.273599752071555					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617817	20617867	23037854	23037904	12686	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-11				TTGGGGCTGGGGATCTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43289937439129123					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617748	20617798	23037785	23037835	12687	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-12				AGAGGGCTGGGTGAGGTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1008610771682199					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617697	20617747	23037734	23037784	12688	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-13				TGCTGATTCAGTTCCTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.179844012587744					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617679	20617729	23037716	23037766	12689	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-14				GAGGGGGTCTTCAAACTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14088877944341521					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617858	20617908	23037895	23037945	12690	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-15				CTTCCTCCCATCTCCTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15223262438817189					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617896	20617946	23037933	23037983	12691	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-16				CCTCTTTCTCTGCTGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1711609643064354					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617573	20617623	23037610	23037660	12692	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-17				TGCACTCCTGCACTCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054401283352331249					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617591	20617641	23037628	23037678	12693	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-18				AGAGTCTTGCTTTGTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77506278132968243					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617803	20617853	23037840	23037890	12694	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-2				CTTAAGGGGTTTGGATGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63478358758239717					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617766	20617816	23037803	23037853	12695	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-3				GGATTGTTGATTGGTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5621660765539882					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617927	20617977	23037964	23038014	12696	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-4				TGTATTGACTTGTCATGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28738555259957332					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617836	20617886	23037873	23037923	12697	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-5				GCCTCAAACCCCAAGGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19085751166344089					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617647	20617697	23037684	23037734	12698	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-6				TTCCAATTGAATTCAGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54677802645970242					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617945	20617995	23037982	23038032	12699	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-7				ACTGGGGAAGGAACCTGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2383785762627447					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617871	20617921	23037908	23037958	12700	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-8				AATCATCAGGCAGCCAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.099337918940621772					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76955	chr18	20617884	20617934	23037921	23037971	12701	hg38	N/A	enh32504	N/A	Enhatls82574	enhancer	GATA6e-10-9				AGAGAAAGAGGTTAATCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78901584362938737					RBBP8	chr18	22798260	23026488	3039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	973
enhrx-76958	chr18	20749852	20749902	23169888	23169938	12702	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-1				ACAGTGGCGGACTCCAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53598979761413679					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749429	20749479	23169465	23169515	12703	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-10				CATATGTTTAACCATAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0336125668590288					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749570	20749620	23169606	23169656	12704	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-11				CCAAGTCATTCCTCCCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0069125084056932641					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749864	20749914	23169900	23169950	12705	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-12				TCCGCCACTGTGTGGGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17203075243908669					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749462	20749512	23169498	23169548	12706	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-13				GCACTTCTCTGTGAAATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.076002330697720347					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749484	20749534	23169520	23169570	12707	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-14				AACTGCTTTGCTGACAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47393876319342448					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749388	20749438	23169424	23169474	12708	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-15				CATGATATGTTATGTCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27911851247074643					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749737	20749787	23169773	23169823	12709	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-16				ATCAGAATTTGAAAGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24444198292815941					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749710	20749760	23169746	23169796	12710	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-17				TCTCCAGAAGCTTGTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50791356907140728					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749822	20749872	23169858	23169908	12711	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-18				GAGGTTTTCAAAGGAACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99630266524097977					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749584	20749634	23169620	23169670	12712	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-19				GAAATAAAGTTTTACCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14495492825182921					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749839	20749889	23169875	23169925	12713	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-2				AACCTCGTGTTTCCCGTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16613143888794041					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749991	20750041	23170027	23170077	12714	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-20				ATCTCTGCCCTTCCAGAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1738300588002355					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749962	20750012	23169998	23170048	12715	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-21				GAGAGGGATAGGGCATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30593615486370429					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749876	20749926	23169912	23169962	12716	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-22				TGGGGTCATGGGCAGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22711942446237729					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749776	20749826	23169812	23169862	12717	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-23				TTGGGATGAGGGGTCTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085811600736762708					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749916	20749966	23169952	23170002	12718	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-24				CTACAGCTCCCACCAAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.312573891534925					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20748927	20748977	23168963	23169013	12719	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-25				GCATTCTAAATCACAGGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045406426679023608					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749973	20750023	23170009	23170059	12720	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-26				CAGGGGGAGCTGAGAGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1066484659103117					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749671	20749721	23169707	23169757	12721	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-27				TTCTAACACAGCAGCAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1142027926522567					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749806	20749856	23169842	23169892	12722	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-28				GAGCTGCTGAGGCTCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37917922167718349					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749526	20749576	23169562	23169612	12723	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-29				GGGGGAAGGGGCTTCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062459202029878987					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749511	20749561	23169547	23169597	12724	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-3				CTTATGTTAATGGTGCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32749062129893819					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749795	20749845	23169831	23169881	12725	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-30				GTGGTGTGTGTGAGCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0050069487112725224					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749223	20749273	23169259	23169309	12726	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-31				CCCTCAGGGCTGCTCTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.198246649926704					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749129	20749179	23169165	23169215	12727	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-32				GTTACCCTATATGGTCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.107998932906893					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749044	20749094	23169080	23169130	12728	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-33				ATGACCAGAGGTCACTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46548049869880648					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749309	20749359	23169345	23169395	12729	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-34				ATCTCGTGCAAGAAAGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0027381122575306492					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20748996	20749046	23169032	23169082	12730	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-35				ACAGGTTACAGTAAAAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9014995598231933					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749279	20749329	23169315	23169365	12731	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-36				ATAAACTTGTTTTCACTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31697023636610339					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749029	20749079	23169065	23169115	12732	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-37				TCTAGTGGCCATTTTGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027494516794415221					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749104	20749154	23169140	23169190	12733	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-38				ACAGATGCCGTGGCAACGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2049445057984598					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20748914	20748964	23168950	23169000	12734	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-39				TTTAGAATGCCTTAACCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53449469698452012					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749413	20749463	23169449	23169499	12735	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-4				ATAGCGGGTCTTCAGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0917037122208567					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749339	20749389	23169375	23169425	12736	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-40				CTGATCCAGACCCCAACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34810588759280447					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749092	20749142	23169128	23169178	12737	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-41				ACGGCATCTGTAAACTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41356846605766828					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20748983	20749033	23169019	23169069	12738	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-42				TGTAACCTGTTTTATCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14756317046753681					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20748951	20749001	23168987	23169037	12739	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-43				AGGAGGTCAGCACAAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79016099427309					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749327	20749377	23169363	23169413	12740	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-44				GAGATCCAAGAACCCTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13083178900624351					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749209	20749259	23169245	23169295	12741	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-45				TGGGCAACCAGCAGCCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46563619403080619					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749056	20749106	23169092	23169142	12742	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-46				GTAGCAGTGAGGATGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4194749605945169					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749167	20749217	23169203	23169253	12743	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-47				ATGATATGCTAAACAAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.690230618888513					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749067	20749117	23169103	23169153	12744	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-48				CTGGTGGGAGTGTAGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3500621355999121					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749189	20749239	23169225	23169275	12745	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-49				TCAAGAAATAACCATAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3598996683389011					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749758	20749808	23169794	23169844	12746	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-5				GGATAGGTGCCCTGTTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33411018249513369					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749930	20749980	23169966	23170016	12747	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-6				GAGCTGTAGCCGCGTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2318511626688109					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749371	20749421	23169407	23169457	12748	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-7				ATCATGCATACTTACATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081563030767926634					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749547	20749597	23169583	23169633	12749	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-8				GTTTAATGCCTTGGTTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74372203509759027					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76958	chr18	20749898	20749948	23169934	23169984	12750	hg38	N/A	enh102300	N/A	Enhatls82576	enhancer	GATA6e-11-9				GCAGGTGGCTCATGCTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29968403393648568					CABLES1	chr18	23134563	23260470	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-76965	chr18	20865675	20865725	23285711	23285761	12751	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-1				AAGAATTGGGACTTAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17218962409467031					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865707	20865757	23285743	23285793	12752	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-10				AGGATTATAGGGTGGAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.888539612110832					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865550	20865600	23285586	23285636	12753	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-11				GATTTGGGACAAGTTGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15901789592025661					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865584	20865634	23285620	23285670	12754	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-12				GGACTGAGGGGACAGGCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77731438366846					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865536	20865586	23285572	23285622	12755	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-13				TGCATTGGGAACAGAGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19392870464070719					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865662	20865712	23285698	23285748	12756	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-14				TAGCCTGGGGAGGAGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.005930540973103					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865490	20865540	23285526	23285576	12757	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-15				GTCTGAGGTGCATGACGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50470313623391683					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865566	20865616	23285602	23285652	12758	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-16				GAAGGGAAAGAAGGAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.947321684723142					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865640	20865690	23285676	23285726	12759	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-17				GTCAGATAGGTCTGTAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1108476418250861					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865786	20865836	23285822	23285872	12760	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-18				ATTGCTGGGCGGGTGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.7483252846265489					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865689	20865739	23285725	23285775	12761	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-19				AGCGGAGGCTGAGGAAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84738736347435839					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865719	20865769	23285755	23285805	12762	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-20				GGAGGTGATAAAAGGATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.36314419341886					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865828	20865878	23285864	23285914	12763	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-21				TGGAGCTAAAGGCATAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0098596316880071					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865509	20865559	23285545	23285595	12764	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-3				CAGGCTTTCTTTTACACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40582649021167722					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865746	20865796	23285782	23285832	12765	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-4				CTCACACCGGGTCCGGCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23222447981378841					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865797	20865847	23285833	23285883	12766	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-5				TTTAAGAGGAAATTGCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01537724346232008					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865733	20865783	23285769	23285819	12767	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-6				ATCACCTCCCCTCCTCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55187184034533654					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865758	20865808	23285794	23285844	12768	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-7				CATGGAATGAAACCGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012384840892779079					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865811	20865861	23285847	23285897	12769	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-8				GCTCCAGCCACCTTTTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2397400620294215					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865605	20865655	23285641	23285691	12770	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12-9				ACTCAGCGACGTTTGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76790902479483736					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20865863	20865913	23285899	23285949	12771	hg38	N/A	enh4720	N/A	Enhatls82585	enhancer	GATA6e-12/EOMESe-26				TTTCTTTATCCCAAATCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80999688853112883					TMEM241	chr18	23296012	23437961	7802				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869653	20869703	23289689	23289739	12772	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-1				GTGACCTGCACACATCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027224361028320512					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869668	20869718	23289704	23289754	12773	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-10				TAAGGCAGGAACCGGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37703998048791842					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869886	20869936	23289922	23289972	12774	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-11				AGCAAAGGGAGATAGGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.4192731569697852					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869704	20869754	23289740	23289790	12775	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-15				CACCACAAAAGAAGTGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6624721827069211					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869755	20869805	23289791	23289841	12776	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-16				TCTTGTGAAATTCCTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1942468304406859					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869767	20869817	23289803	23289853	12777	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-17				AGCCAGGATGAGCCAGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49579460690468241					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869901	20869951	23289937	23289987	12778	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-18				TCCGAAAAGAGAGTCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.735104799755671					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869617	20869667	23289653	23289703	12779	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-2				TTAGCTTGGGCTCAGAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1824753259171342					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869630	20869680	23289666	23289716	12780	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-24				GGGATATGATGGCTTAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.422738891645368					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869641	20869691	23289677	23289727	12781	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-3				GTGCAGGTCACGGGATATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4409081844785539					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869846	20869896	23289882	23289932	12782	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-4				GGTAGGTAAAGGAAAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.621706175696418					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869599	20869649	23289635	23289685	12783	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-5				TATAAGAAGACAGGAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82472115466947837					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869827	20869877	23289863	23289913	12784	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-6				GGGGTTGTTCTCTGGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066544742227679879					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869811	20869861	23289847	23289897	12785	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-7				AGGCAGGAGTGGGGGTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8048902370402231					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869940	20869990	23289976	23290026	12786	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-8				ATAAAGCTGTTTATTTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86120574600221722					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869737	20869787	23289773	23289823	12787	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13-9				CAAGATAATGTCATCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7897468354829601					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869783	20869833	23289819	23289869	12788	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13/SMAD4e-11				AGTAGGGGAGCTTTTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.73602132537161					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-76965	chr18	20869922	20869972	23289958	23290008	12789	hg38	N/A	enh62670	N/A	Enhatls82585	enhancer	GATA6e-13/SMAD4e-11				GACTCAGCCCGCCTGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.231406237898933					TMEM241	chr18	23296012	23437961	1786				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	983
enhrx-77083	chr18	21519000	21519050	23939036	23939086	12790	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-1				CTGCGGGTCACTGACTGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14002662194210971					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77084	chr18	21519312	21519362	23939348	23939398	12791	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-10				CTTGCTATTCAAGCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52670055121949355					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77083	chr18	21519052	21519102	23939088	23939138	12792	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-11				CAATAGAAGGCCTGGTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47684495733429122					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-lit85	chr18	21519285	21519335	23939321	23939371	12793	hg38					enhancer	GATA6e-14-12				TGGTGGGAATGTCCCCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5576375832387281													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit86	chr18	21519257	21519307	23939293	23939343	12794	hg38					enhancer	GATA6e-14-13				TCCATGATTGGCCTGGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65942653902839266													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77084	chr18	21519378	21519428	23939414	23939464	12795	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-14				CGCAGAGTCAGGTTCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19601673749563581					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77084	chr18	21519407	21519457	23939443	23939493	12796	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-15				ATGGCAGTCAGACTTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2559901209283541					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77083	chr18	21519017	21519067	23939053	23939103	12797	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-16				TCCGCTGAGAGCCCTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16558335877020169					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77084	chr18	21519301	21519351	23939337	23939387	12798	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-17				TTGAATAGCAAGTGGCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050882436892965122					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77084	chr18	21519347	21519397	23939383	23939433	12799	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-18				CAGGAAAGCTAAATAATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82898065292265954					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77084	chr18	21519426	21519476	23939462	23939512	12800	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-19				GAGAGAGCTGCATGGTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52103113347255647					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77084	chr18	21519389	21519439	23939425	23939475	12801	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-2				TGAGGTGGAATCGCAGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4040249083396904					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77084	chr18	21519329	21519379	23939365	23939415	12802	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-20				CTCAGGAGCTGCTGAAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13840203825228711					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-lit87	chr18	21519246	21519296	23939282	23939332	12803	hg38					enhancer	GATA6e-14-21				CTCACCACTTCCCAAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26789195984050312													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77083	chr18	21519153	21519203	23939189	23939239	12804	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-22				AAGAGCAACACAATTATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095883537176095587					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77083	chr18	21519174	21519224	23939210	23939260	12805	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-23				TTTTCCCATGCAGCTGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02656314091038961					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77083	chr18	21518986	21519036	23939022	23939072	12806	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-24				CTGGTATGGAGTGGGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11420069689841519					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77084	chr18	21519366	21519416	23939402	23939452	12807	hg38	N/A	N/A	N/A	Enhatls82728	enhancer	GATA6e-14-25				TTCTGAGCTGGTGCTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1748891751285217					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1102
enhrx-77083	chr18	21519087	21519137	23939123	23939173	12808	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-3				TTCACCCTTGATCCTAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.059209398023935572					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-77083	chr18	21519035	21519085	23939071	23939121	12809	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-4				GCGGAAACTTCCCATCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18995995837473739					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-lit88	chr18	21519272	21519322	23939308	23939358	12810	hg38					enhancer	GATA6e-14-5				ATCATGGAGCCCTCCAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.242156541175518													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit89	chr18	21519213	21519263	23939249	23939299	12811	hg38					enhancer	GATA6e-14-6				GCCACACCTTCACGCTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14551962287672049													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77083	chr18	21519075	21519125	23939111	23939161	12812	hg38	N/A	N/A	N/A	Enhatls82727	enhancer	GATA6e-14-7				CCCTACTGAATTCCTCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69722754296256562					LAMA3	chr18	23689452	23956222	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1101
enhrx-lit90	chr18	21519186	21519236	23939222	23939272	12813	hg38					enhancer	GATA6e-14-8				GCTGTTGCAGGACACACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18665083728749959													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit91	chr18	21519202	21519252	23939238	23939288	12814	hg38					enhancer	GATA6e-14-9				ACGCTCCTTGGGGAGGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.506132194216325													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-76936	chr18	19904853	19904903	22324890	22324940	12815	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-1				GTGAAGCAAGCAGTCGCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24468113469383079					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904199	19904249	22324236	22324286	12816	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-10				TCTTGAGAGCTCCAGCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15621244504647361					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904593	19904643	22324630	22324680	12817	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-11				TATTGGGCTGCACCTCCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.032340201550408447					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904752	19904802	22324789	22324839	12818	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-12				AGTGGGTGGGCGCTTCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1837739859394768					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904659	19904709	22324696	22324746	12819	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-13				CGCTCTCATTTTGGTAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16410589527308289					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904659	19904709	22324696	22324746	12820	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-13				CGCTCTCATTTTGGTAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16410589527308289					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904287	19904337	22324324	22324374	12821	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-14				CTAGGGCACTCGCCCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83083506100834625					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904118	19904168	22324155	22324205	12822	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-15				TTAAATGGACTGCACCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41218157913983211					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904252	19904302	22324289	22324339	12823	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-16				GAGGGGCGCGCAGCTTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39098312829546811					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904319	19904369	22324356	22324406	12824	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-17				CACGTGCCTGAGCTCCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1665114361113261					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904578	19904628	22324615	22324665	12825	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-18				GATGAGGCCTAATGGCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6469544845461721					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904817	19904867	22324854	22324904	12826	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-19				GGAGGAGCGAGGGACCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40851355422753222					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904529	19904579	22324566	22324616	12827	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-2				CGGGTGGATTCCGAAACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2187258733661579					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904304	19904354	22324341	22324391	12828	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-20				CAAGCTGGAGTCAGGACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38497052267519422					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904480	19904530	22324517	22324567	12829	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-21				CATAAATCTTGCCAGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74939348229921754					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904271	19904321	22324308	22324358	12830	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-22				GCGGGCACACAGCGAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.239037527502763					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904187	19904237	22324224	22324274	12831	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-23				AGCTCTCAAGACTGCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0463551460157905					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904367	19904417	22324404	22324454	12832	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-24				TCCTCGTGCTGGGAGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16289379996677031					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904103	19904153	22324140	22324190	12833	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-25				CAATAATTTATGCTTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37657869344521588					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904831	19904881	22324868	22324918	12834	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-26				GGCTCCACCATTCCCCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0021098008370998471					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904562	19904612	22324599	22324649	12835	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-27				TGCACATTTTACCTGGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.173391578006175					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904449	19904499	22324486	22324536	12836	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-28				ACACTTCCTGCTGTGAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14399876715488211					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904068	19904118	22324105	22324155	12837	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-29				TAAACAAAGTGAGTACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2036214028482512					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904501	19904551	22324538	22324588	12838	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-3				GGGGAGCCGGTTAGGAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31681637229920739					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904783	19904833	22324820	22324870	12839	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-30				CCCCCGGGAGGGTGGAGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30620098241797961					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904392	19904442	22324429	22324479	12840	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-31				TGCACACTAACAGAAAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30225708945736762					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904768	19904818	22324805	22324855	12841	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-32				CACGTGGACAGAGGGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36842778810081411					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904703	19904753	22324740	22324790	12842	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-33				TGGGAAGGTTTTGTCCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2306056075490176					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904431	19904481	22324468	22324518	12843	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-34				TGAGGGGCTTTTCTGTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29404026555879309					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904133	19904183	22324170	22324220	12844	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-35				GGAGCTCCTGGAGATTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29858017854040692					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904352	19904402	22324389	22324439	12845	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-36				CGGCTACTTCAGCTTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.085320822555362053					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904795	19904845	22324832	22324882	12846	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-37				TGGAGCGAGGGGCCCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.121895145806969					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904738	19904788	22324775	22324825	12847	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-38				CAGGCAGTGGTTTGAGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31890030820959131					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904332	19904382	22324369	22324419	12848	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-39				CAGGCACGTGTGGGATGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0928458675475241					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904378	19904428	22324415	22324465	12849	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-4				AAGTAATGGAATCCTCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1061710163315116					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904719	19904769	22324756	22324806	12850	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-40				CCTGAGGAAGCAAAGAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63471338925937826					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904228	19904278	22324265	22324315	12851	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-41				CTTGGCTGGGCTGGGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.672992097237751					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904210	19904260	22324247	22324297	12852	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-42				CCAGCGGGCAGGGCTGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68976512021921488					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904806	19904856	22324843	22324893	12853	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-43				GCCCCTGGGAGGGAGGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8487083332800136					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904046	19904096	22324083	22324133	12854	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-5				ACCGTTCAATTCTGTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53267301876551232					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904610	19904660	22324647	22324697	12855	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-6				TTAATTTGTCGACCTCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46088389610322722					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904548	19904598	22324585	22324635	12856	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-7				AAATGTGCAAAGGGCGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065700414380777852					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904685	19904735	22324722	22324772	12857	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-8				TCCCACGCCCTAGACTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.538114070252244					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904685	19904735	22324722	22324772	12858	hg38	N/A	enh17590	fant54687	Enhatls82553	enhancer	GATA6e-2-8				TCCCACGCCCTAGACTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.538114070252244					CTAGE1	chr18	22413598	22417915	88613				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19904155	19904205	22324192	22324242	12859	hg38	N/A	enh17590	N/A	Enhatls82553	enhancer	GATA6e-2-9				CGAATTGCTCTTGAAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062409302039736762					CTAGE1	chr18	22413598	22417915	88876				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912646	19912696	22332683	22332733	12860	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-1				TGCACCGTGCTAAATAACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28851245490134791					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912854	19912904	22332891	22332941	12861	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-10				GACAGTTAGAAGCAAGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41842541959671248					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912764	19912814	22332801	22332851	12862	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-11				ATGGGAGGCAGGGTTTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12369959028074461					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912674	19912724	22332711	22332761	12863	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-12				GCAGCAAATGCAGACCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28249141393921429					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912825	19912875	22332862	22332912	12864	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-13				AGAATCCCCTCTCCTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59430007417011055					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912837	19912887	22332874	22332924	12865	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-14				TGCTGGGCCAGCCCACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23736804116965579					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912788	19912838	22332825	22332875	12866	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-15				ACTGGGAAGTGGAGATCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20345056191504721					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912746	19912796	22332783	22332833	12867	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-2				TAGTTCCCCAAATGGACGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0909032166476907					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912907	19912957	22332944	22332994	12868	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-3				AGTCTCCCGTCAGTTAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.261746006296182					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912703	19912753	22332740	22332790	12869	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-4				GGATGATGCAGCAACACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39233730204754652					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912624	19912674	22332661	22332711	12870	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-5				GTATTTGCCCTGTAGAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41797725820752452					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912660	19912710	22332697	22332747	12871	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-6				CACGGTGCATAAGGCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0079481936953790158					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912726	19912776	22332763	22332813	12872	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-7				CTACAGATTGTCTTGTACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16767200681440991					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912873	19912923	22332910	22332960	12873	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-8				TGTCGGAGAATGACAAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10365179333971419					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76936	chr18	19912805	19912855	22332842	22332892	12874	hg38	N/A	N/A	N/A	Enhatls82553	enhancer	GATA6e-3-9				TCTACAGTGATGTGGCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38791251632760032					CTAGE1	chr18	22413598	22417915	79957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	954
enhrx-76937	chr18	20116682	20116732	22536719	22536769	12875	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-1				GGCCGAGCAACAAGTCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2636916430539365					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116939	20116989	22536976	22537026	12876	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-10				GACTTTTTCAAGCTACAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39285400962178529					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116727	20116777	22536764	22536814	12877	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-11				AGGCTGTCAGTGGAGCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47658108854675929					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116882	20116932	22536919	22536969	12878	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-12				TCTAATCTCATCAAGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1357748519023421					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116623	20116673	22536660	22536710	12879	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-13				CTGTTCCTGTGCAAGAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42385479315388119					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116741	20116791	22536778	22536828	12880	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-14				GCTATCTGGGCAAGCCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33462017859178073					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116787	20116837	22536824	22536874	12881	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-15				ATCAACACCTTAAACTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49627787570585752					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116910	20116960	22536947	22536997	12882	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-16				GATTCTCAAGACTGTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070703863019092927					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116852	20116902	22536889	22536939	12883	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-17				AATAAAGCCATCAGAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28121869629981078					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116663	20116713	22536700	22536750	12884	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-18				GGCCTGCCACGCCTCCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39856597072311939					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116962	20117012	22536999	22537049	12885	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-19				GCAGTGATTCTGGGTGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24729622277089269					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116817	20116867	22536854	22536904	12886	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-2				CCTTCAAAGCGTGACAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13570244194136369					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116567	20116617	22536604	22536654	12887	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-20				CAGGTCATTGTGTTTTTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25641566397920718					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116524	20116574	22536561	22536611	12888	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-21				ATTTTGTTTGTTTTTATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1221367117112319					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116594	20116644	22536631	22536681	12889	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-3				GGATCGCCAGACAAAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36003034400565442					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116768	20116818	22536805	22536855	12890	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-4				TTGGAGATAAAGGGCCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2050727221789013					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116548	20116598	22536585	22536635	12891	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-5				CCACTACACAATCTCTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.099698387711371447					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116649	20116699	22536686	22536736	12892	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-6				AGAAGTTTTCTGGCCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17318713442079289					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116693	20116743	22536730	22536780	12893	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-7				AAGTCACTATGGCGGACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36723440977986732					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116756	20116806	22536793	22536843	12894	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-8				GGCCCTTTTGGAATTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.287956992434992					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20116707	20116757	22536744	22536794	12895	hg38	N/A	N/A	N/A	Enhatls82554	enhancer	GATA6e-4-9				GACACATGGCGACTGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033163840936313277					CTAGE1	chr18	22413598	22417915	101678				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139752	20139802	22559789	22559839	12896	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-1				ACAACCGCCCGGTTCCGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29540513176819028					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139506	20139556	22559543	22559593	12897	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-10				TCGCTGACACCCACCCGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.1170577434410607					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139506	20139556	22559543	22559593	12898	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-10				TCGCTGACACCCACCCGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.1170577434410607					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139469	20139519	22559506	22559556	12899	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-11				TCCAAGAGGTCCTCCCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02011805676415538					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139947	20139997	22559984	22560034	12900	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-12				CCTGGTTATTTGTAGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42896520392415249					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139543	20139593	22559580	22559630	12901	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-13				ACGCTTGTCCTCTCCCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23619000551801059					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139929	20139979	22559966	22560016	12902	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-14				GTGACAGCCGGGACAGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40036759672866118					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139416	20139466	22559453	22559503	12903	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-15				GCATTAGTTTGGAGGTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2586804378451637					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140040	20140090	22560077	22560127	12904	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-16				ATCATGCTTTGAGTTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18924825230070019					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139436	20139486	22559473	22559523	12905	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-17				GGGACACGCAGCTGTTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50926005241609029					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139767	20139817	22559804	22559854	12906	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-18				CGACCCGGCCCGGACGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4499029616212199					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139819	20139869	22559856	22559906	12907	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-19				GAGGGCCGGCGAGCCCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.339924228845565					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139963	20140013	22560000	22560050	12908	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-2				TACAGCGAAATGAAAGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28481814102530079					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139639	20139689	22559676	22559726	12909	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-20				CTGAAGGAGCGCAGCCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17845709760700859					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139711	20139761	22559748	22559798	12910	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-21				ACCGGGCGGCCGGGGGCGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.5461528586639979					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139557	20139607	22559594	22559644	12911	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-22				ACATTGGCCAGGGCCCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1945201023626451					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140015	20140065	22560052	22560102	12912	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-23				AAACAGAGAAACCTATAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98138515892139333					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139917	20139967	22559954	22560004	12913	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-24				GGCTCCTCTTCAGTGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048233110662154861					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139783	20139833	22559820	22559870	12914	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-25				ACAGAGTCCCCCGCCCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.085135141945124934					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139610	20139660	22559647	22559697	12915	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-26				ATAAGTTAATGTACACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76775033620882471					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139833	20139883	22559870	22559920	12916	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-27				CGCCTCTGCCCTGCCCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13911739333711609					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139488	20139538	22559525	22559575	12917	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-28				GATGGAGCCGCCAGGCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083769818147701167					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139488	20139538	22559525	22559575	12918	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-28				GATGGAGCCGCCAGGCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083769818147701167					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139722	20139772	22559759	22559809	12919	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-29				GGGGGCGACTGGGGAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67960262466255739					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139625	20139675	22559662	22559712	12920	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-3				TAACTTATCTGCAGCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010597849765466591					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139666	20139716	22559703	22559753	12921	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-30				TCCCAGGCTGCGCAGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88290902678291594					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139801	20139851	22559838	22559888	12922	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-31				TCTGTGGGGCCAGGCGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2145609297246811					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139983	20140033	22560020	22560070	12923	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-32				GTAATTAAGCAGTCATTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.441375623036977					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139455	20139505	22559492	22559542	12924	hg38	N/A	enh17595	N/A	Enhatls82554	enhancer	GATA6e-5-33				AAGGAAAGCCTGGCTCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22475190110223051					CTAGE1	chr18	22413598	22417915	141279				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139568	20139618	22559605	22559655	12925	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-34				GCAGCAGCAGGACATTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25923650129959169					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139682	20139732	22559719	22559769	12926	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-35				CTGGGTCGGGGAAGGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4762392709284391					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139655	20139705	22559692	22559742	12927	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-36				GCAGGAGACAGGCTGACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48875539599452811					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140092	20140142	22560129	22560179	12928	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-37				AAGGAGGCGTGGAGGGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.019288744257383309					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139844	20139894	22559881	22559931	12929	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-38				AGGGCAGAGGCGGGCGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16821470261651261					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140055	20140105	22560092	22560142	12930	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-39				CCAGTGGGGGCAGCAGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.361874249886462					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139866	20139916	22559903	22559953	12931	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-4				GGCTGGCGGCGAACACTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40202799367152142					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140069	20140119	22560106	22560156	12932	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-40				AGGGAGTGGAAGGGGAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.2174368630615922					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140081	20140131	22560118	22560168	12933	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-41				GGGAGGTTGGGAAGGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4303951932071364					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139580	20139630	22559617	22559667	12934	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-5				TTACCACGACCCGCAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26240277417958768					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20140004	20140054	22560041	22560091	12935	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-6				GGTCATTTCATCCCCGTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10471984331953491					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139700	20139750	22559737	22559787	12936	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-7				CGGCCGCCCGGTGGGTCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80336675285638659					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139741	20139791	22559778	22559828	12937	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-8				TGGGAATCACAACAACCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038712938777740312					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76937	chr18	20139896	20139946	22559933	22559983	12938	hg38	N/A	enh17595	fant54704	Enhatls82554	enhancer	GATA6e-5-9				ATGACTCATGACTCATGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14370007981090929					CTAGE1	chr18	22413598	22417915	141658				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-76938	chr18	20410006	20410056	22830043	22830093	12939	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-1				GATTTTACGTGGTAGTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2577609868049035					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20410043	20410093	22830080	22830130	12940	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-10				ACACTACAGAAGATAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74823111169792922					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409843	20409893	22829880	22829930	12941	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-11				TCTGAGTCTCCTGCCGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.206361616522285					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409933	20409983	22829970	22830020	12942	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-12				ACACTTGTCTTTGTCCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0091559774372430569					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409830	20409880	22829867	22829917	12943	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-13				AATAATCTGGGCTCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73552874810649971					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20410061	20410111	22830098	22830148	12944	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-14				AATTTGGTTTCTCTATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55918129234410319					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409818	20409868	22829855	22829905	12945	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-15				AAAGTCTATTGAAATAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.899526168253618					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409858	20409908	22829895	22829945	12946	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-2				GACTCAGACCAACTAATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3024293134830397					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409887	20409937	22829924	22829974	12947	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-3				TTAGCTAGAGCAATGGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47277445887332559					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20410017	20410067	22830054	22830104	12948	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-4				CTTTAGTCTCAGATTTTACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55135149438364073					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409919	20409969	22829956	22830006	12949	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-5				CCAACAGAGTCACACCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38067813866727163					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409762	20409812	22829799	22829849	12950	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-6				TTGTTAGCCATCTTTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45141023402817632					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20410077	20410127	22830114	22830164	12951	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-7				CAAGCAGTACCTTCAGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22777520577255789					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409972	20410022	22830009	22830059	12952	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-8				ACACAAGCTGAGAGGATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7515040705706606					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20409948	20409998	22829985	22830035	12953	hg38	N/A	enh32503	N/A	Enhatls82556	enhancer	GATA6e-6-9				ACAAGTGTGTTCTTGTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38561058662984349					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418994	20419044	22839031	22839081	12954	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-1				AAAGCGAAGCCACACCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37903806377138982					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418619	20418669	22838656	22838706	12955	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-10				CTTGTTCTGTAGGGAGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.449054619538818					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418928	20418978	22838965	22839015	12956	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-11				GCAGAAATGAGCAGGGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19795463867290469					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418880	20418930	22838917	22838967	12957	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-12				TGCCTTATCTGCCAGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.285292827245347					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418897	20418947	22838934	22838984	12958	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-13				AAGGCACTGAAGTGAGTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64859682622094694					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418671	20418721	22838708	22838758	12959	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-14				GAAAGGAACTCTCCCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042209468852712					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418654	20418704	22838691	22838741	12960	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-15				TGTACTTAGAAGCTCCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24161492090011269					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418608	20418658	22838645	22838695	12961	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-16				GGGAGCATCTGGTGAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.003870055437254286					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418964	20419014	22839001	22839051	12962	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-17				GAAAGTGAGTGCTTTTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49729169199243373					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418858	20418908	22838895	22838945	12963	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-18				GTGTTTTCATGGGCAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34176373814518868					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418846	20418896	22838883	22838933	12964	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-19				GCAGAAATAGGTTGTAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19741647737091211					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418798	20418848	22838835	22838885	12965	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-2				GTTTCGTAGCAGGGGTACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.320340585477994					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418759	20418809	22838796	22838846	12966	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-20				TATCTCTCAAGGCAGTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1967367170317848					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418812	20418862	22838849	22838899	12967	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-21				CTACGAAACTCTCTCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13766293470982749					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418770	20418820	22838807	22838857	12968	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-22				AAATTGATTGTTATCTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1081148683413709					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20419008	20419058	22839045	22839095	12969	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-23				GTACAGGCTTCCTGCCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040244621759855423					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20419024	20419074	22839061	22839111	12970	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-24				TAGCTTAGGGGAAGAAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73667132015665138					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418700	20418750	22838737	22838787	12971	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-3				AAATCGACTGTTATTTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15799889397096151					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418686	20418736	22838723	22838773	12972	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-4				TTTGTGAGGCAGTCTCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38875077910070449					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418738	20418788	22838775	22838825	12973	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-5				GGTGGGAGCGAATTTTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42745283733083078					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418830	20418880	22838867	22838917	12974	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-6				AGAGTGGTTGAAAACTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1388612262206578					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418726	20418776	22838763	22838813	12975	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-7				TTTTGTGGTGGACACATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.075609996621904763					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418869	20418919	22838906	22838956	12976	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-8				CCATGAAAACACCAGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21027277776620809					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20418951	20419001	22838988	22839038	12977	hg38	N/A	enh48106	N/A	Enhatls82556	enhancer	GATA6e-7-9				TTTAAAGGGGAGCTTATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24530855371062479					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20452034	20452084	22872071	22872121	12978	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-1				GCTCCTTTGTGGCCTCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.155678491486957					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451930	20451980	22871967	22872017	12979	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-10				CAAATGCCAGTGACCTCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33863483498902419					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451831	20451881	22871868	22871918	12980	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-11				CTTGCTGTGGCTAGCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033675516817596618					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451743	20451793	22871780	22871830	12981	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-12				CAAATAGGGTCATCAAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095962588544839					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451941	20451991	22871978	22872028	12982	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-13				GACCTCATAGGGAGAGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.214202712762531					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451846	20451896	22871883	22871933	12983	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-14				ACAGCAAGAGCCCCAAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84453371950042777					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451796	20451846	22871833	22871883	12984	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-15				AGATTTGAGAGAAGCTATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.268631196797695					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451754	20451804	22871791	22871841	12985	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-16				ATCAAGAAGAGGTCATTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28944688598717933					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451858	20451908	22871895	22871945	12986	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-17				ACAGTAACCTCTCCTCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070990799192243076					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451772	20451822	22871809	22871859	12987	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-18				AAGGGACTATTTACAAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62682657207761161					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451974	20452024	22872011	22872061	12988	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-19				GAGGGAGGAGAATGTGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012727785970187909					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451909	20451959	22871946	22871996	12989	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-2				TGGCCACATTCCTCTAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0089798798784644189					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451732	20451782	22871769	22871819	12990	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-3				TGACCCTATTTGAGTATAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23357858082771021					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20452022	20452072	22872059	22872109	12991	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-4				CACTGATCAAAACCAACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1157728369180063					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20452007	20452057	22872044	22872094	12992	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-5				GATCAGTGGGGAGCATCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1127150793869115					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451896	20451946	22871933	22871983	12993	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-6				CTAATGGAGGCCACATCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1520672244127205					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451883	20451933	22871920	22871970	12994	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-7				CATCTGTAGGAGGCTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01823134564489632					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451996	20452046	22872033	22872083	12995	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-8				AGCATCAATAGGAAATCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067408861325982714					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20451817	20451867	22871854	22871904	12996	hg38	N/A	enh99474	N/A	Enhatls82556	enhancer	GATA6e-8-9				GGAAGAATGTAGCACCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25275724322073762					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493742	20493792	22913779	22913829	12997	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-1				CCACGAGAGTCTTATAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53613304406568152					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493988	20494038	22914025	22914075	12998	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-10				CCTGTTGTGCCAACATATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22358523947705261					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493777	20493827	22913814	22913864	12999	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-11				GGGAGGGGTAGATCTGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14766061674566941					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20494046	20494096	22914083	22914133	13000	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-12				ATGCCTTTCATTTAACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01216738581469266					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493794	20493844	22913831	22913881	13001	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-13				TAATTCAGAGTTCTAGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60855155320163956					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493721	20493771	22913758	22913808	13002	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-14				GGTAGACATATATAAGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.129855833053834					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493832	20493882	22913869	22913919	13003	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-15				CAACATTCTGAGTAGTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1159499670071843					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20494012	20494062	22914049	22914099	13004	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-16				TTGATTCCATGTTCCACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091240433766118567					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493806	20493856	22913843	22913893	13005	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-17				ACTCTGAATTATTTTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18036820330627321					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493965	20494015	22914002	22914052	13006	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-2				TACAGAAGAACCGGTTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17333341890666651					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493924	20493974	22913961	22914011	13007	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-3				GGCTAGCCTTTGATACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1010754202872282					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493908	20493958	22913945	22913995	13008	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-4				GCTAGCCCAACTTGCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072626390100461263					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493882	20493932	22913919	22913969	13009	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-5				AGCTCTGCTAAGCTTGTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0982541982891044					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493939	20493989	22913976	22914026	13010	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-6				CAGACTGGTTGGACAGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3415015138827715					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20493843	20493893	22913880	22913930	13011	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-7				GTAGTTTGTTGGGAGTTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87711810074533425					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20494025	20494075	22914062	22914112	13012	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-8				GGGCAGGTTTCTACCGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20521625908488761					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76938	chr18	20494079	20494129	22914116	22914166	13013	hg38	N/A	N/A	N/A	Enhatls82556	enhancer	GATA6e-9-9				AAGCTATATACTGAGTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59473941164867827					RBBP8	chr18	22798260	23026488	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	956
enhrx-76933	chr18	19739352	19739402	22159391	22159441	13014	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-1				CTTACTTGCACTATCACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1053470419073473					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739162	19739212	22159201	22159251	13015	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-10				CCCCTGATTTCTCTCTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0054523534746110424					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739235	19739285	22159274	22159324	13016	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-11				CTTATCTGGGAGCAGCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091543948198288858					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739221	19739271	22159260	22159310	13017	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-12				GTCTGTCTCTCCTGCTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3607016670167445					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739368	19739418	22159407	22159457	13018	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-13				AACTCACCCTGTCTGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27059529217630007					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19738998	19739048	22159037	22159087	13019	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-14				CAACCTCTCTGCTTTCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063414479976406327					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739089	19739139	22159128	22159178	13020	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-15				TCATTTCTCAAAACTCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045495851035332047					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739013	19739063	22159052	22159102	13021	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-16				CTTGCTGGCACTTCACACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23306833049570541					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739038	19739088	22159077	22159127	13022	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-17				AAGCAGCAAAGATAATTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48407212828256241					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739332	19739382	22159371	22159421	13023	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-18				AAGTTTGTGTTTGTTTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45134279399306321					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739124	19739174	22159163	22159213	13024	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-19				CTGCTCCAGGAAGCCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087593139761085945					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739292	19739342	22159331	22159381	13025	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-2				GCTGAGACAAACACTATGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.380552072723804					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739191	19739241	22159230	22159280	13026	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-3				CAGAAAATCGTCACACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1021786157250815					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739137	19739187	22159176	22159226	13027	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-4				TGTTGGAGTGCAACCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052367538630923367					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739409	19739459	22159448	22159498	13028	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-5				GAATATCAGACATTTCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59797052376627657					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739394	19739444	22159433	22159483	13029	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-6				GATTGCAAATAATTCCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1549712687280177					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739068	19739118	22159107	22159157	13030	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-7				GACTTAATCAGACAAGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23376616512964349					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739176	19739226	22159215	22159265	13031	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-8				CTACAGTGGCACTTGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25408629845302638					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19739111	19739161	22159150	22159200	13032	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+1-9				GTGAGTTTTACGACTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.366994412848559					GATA6	chr18	22169588	22202528	9765				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600217	19600267	22020256	22020306	13033	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-1				TTAGCCCATCGCTGTAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2374000733292603					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600388	19600438	22020427	22020477	13034	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-10				CCTTGGACACCACCAATCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3297216501193121					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600415	19600465	22020454	22020504	13035	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-11				GCTATACGTTTTTAATTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0323577645438631					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600697	19600747	22020736	22020786	13036	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-12				GGCAGGGACGTTGCCTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21368010760269851					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600433	19600483	22020472	22020522	13037	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-13				CAAGGAGATACCTTTATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6449633001197941					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600739	19600789	22020778	22020828	13038	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-14				ACTCCAGGGCATGGTGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.046019419089650057					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600371	19600421	22020410	22020460	13039	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-15				GTCTGGGCCACCACCAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5211979212937761					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600606	19600656	22020645	22020695	13040	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-16				AGGCATAAGGAGGGCCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2406973666844756					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600673	19600723	22020712	22020762	13041	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-17				GAAAGGAGAACTCTAGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62458106923503465					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600530	19600580	22020569	22020619	13042	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-18				GTGGCAGCACAGGCACATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.97518293826966063					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600713	19600763	22020752	22020802	13043	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-19				GAGAATTCCTGGAATGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0644333920906091					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600289	19600339	22020328	22020378	13044	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-2				TTAATCATTAGCTCCCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28205313986529018					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600239	19600289	22020278	22020328	13045	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-20				GCTCGGGCACTTCTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.054727442248839311					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600253	19600303	22020292	22020342	13046	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-21				GACTCCTCTCAGTCCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35771002726857892					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600619	19600669	22020658	22020708	13047	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-22				CCTTATGCCTGACCCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67963823578598215					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600725	19600775	22020764	22020814	13048	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-23				CAGGAATTCTCCTGACTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53076609979408118					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600469	19600519	22020508	22020558	13049	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-24				TAAGAGAAGGTGTAAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.91445790614382					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600332	19600382	22020371	22020421	13050	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-25				ATGGGTAGAGAGGAAGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3149921987747826					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600555	19600605	22020594	22020644	13051	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-26				CGAGGGACAGGGGCCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4471302052313					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600542	19600592	22020581	22020631	13052	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-27				TGTGCTGCCACTGCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7624629695682541					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600482	19600532	22020521	22020571	13053	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-28				TAGATGCAAAAGATAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7641588481062871					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600684	19600734	22020723	22020773	13054	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-29				AGTTCTCCTTTCTCCTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82663566569064517					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600511	19600561	22020550	22020600	13055	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-3				CTGGATGGACGTTCGTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53948680434354213					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600456	19600506	22020495	22020545	13056	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-30				AAATTAATGGAGAAAACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1924241994234079					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600657	19600707	22020696	22020746	13057	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-31				GTGAAGGCAGAGAGGAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1116371296303482					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600632	19600682	22020671	22020721	13058	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-4				AGATCAAAGCGAGCCTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4811297111337226					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600400	19600450	22020439	22020489	13059	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-5				CGTATAGCCTTGCCATAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42346793612344669					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600276	19600326	22020315	22020365	13060	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-6				AGCTCCTAAACCTCCTCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93320346598776838					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600584	19600634	22020623	22020673	13061	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-7				GAGATAAATGAGGCCCCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.016581182179382					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600571	19600621	22020610	22020660	13062	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-8				TCCCTCGGCTGACCCCTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.28985102904387					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19600345	19600395	22020384	22020434	13063	hg38	N/A	enh17587	N/A	Enhatls82547	enhancer	GATA6e+10-9				CTCTACCCATACTCAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0552310985245761					GATA6	chr18	22169588	22202528	145355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571562	19571612	21991601	21991651	13064	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-1				GGCCCTTCCGGCTTGTCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55182942255541378					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571151	19571201	21991190	21991240	13065	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-10				GCCTGCTTAAACAAACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33084633042358058					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570875	19570925	21990914	21990964	13066	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-11				TTCTAAATCCAGCTCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54806478211881593					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571052	19571102	21991091	21991141	13067	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-12				GAGGTTGGGACAAATTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1759786848350505					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571203	19571253	21991242	21991292	13068	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-13				GACACTTGGTAAAGTGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4553358442930594					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571298	19571348	21991337	21991387	13069	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-14				CTCTGAAAGTGGCTTGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66075532438191031					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571406	19571456	21991445	21991495	13070	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-15				CAAACAATCCAATTACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28456135086449641					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571550	19571600	21991589	21991639	13071	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-16				AGTGGGAAGGATGGCCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1211840821371877					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571535	19571585	21991574	21991624	13072	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-17				TTCCCACTGGCTTTGCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.065686987123609347					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571252	19571302	21991291	21991341	13073	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-18				ATGAGCTCTGGGTTAACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18553766988965381					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571036	19571086	21991075	21991125	13074	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-19				TCAAGTATTCCTTGTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15926634852628041					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571595	19571645	21991634	21991684	13075	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-2				ATGGTCCGACCTATTGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24211815991899571					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571266	19571316	21991305	21991355	13076	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-20				AGAGCTCATTGTCTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39437097954695					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571088	19571138	21991127	21991177	13077	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-21				TCCAGCCCATCTTGCATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091788089465807354					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571475	19571525	21991514	21991564	13078	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-22				TGGGGGAGAGAGTCACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49243981707373868					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571188	19571238	21991227	21991277	13079	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-23				GTCCCAGGCCAAGTTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1075532107744029					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571100	19571150	21991139	21991189	13080	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-24				TGCATTCTTGGCTTTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33259925844319438					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571222	19571272	21991261	21991311	13081	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-25				TGTCTGCAAACATTTAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90344545714071633					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570997	19571047	21991036	21991086	13082	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-26				TCTATTATTTTAAGGGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35880452887722841					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571287	19571337	21991326	21991376	13083	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-27				GGGCTGCTCTTCTCTGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14352619050447879					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571074	19571124	21991113	21991163	13084	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-28				TGGGCTGGAGGCAATGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0040913295183153406					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570861	19570911	21990900	21990950	13085	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-29				GATTTAGAAGATGCAAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20919235756642471					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571124	19571174	21991163	21991213	13086	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-3				GGGGCAACCCCCTTCTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22042459300210129					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571498	19571548	21991537	21991587	13087	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-30				GACTTTGATGGGTGGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1157290797509448					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571354	19571404	21991393	21991443	13088	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-31				CAGCCCAGAGCCCCAACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30029452234700932					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570979	19571029	21991018	21991068	13089	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-32				ATAGATTTACCCTAAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9706019750915869					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570959	19571009	21990998	21991048	13090	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-33				AGGTGAAGTCAGGAGATTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097079833542857555					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570924	19570974	21990963	21991013	13091	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-34				TATTTCACAAATAAGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.706935482289415					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571614	19571664	21991653	21991703	13092	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-35				TTAATATTTTATAGACTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571441	19571491	21991480	21991530	13093	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-36				TGTTTGGGAAAGTGGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64408804934948571					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571458	19571508	21991497	21991547	13094	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-37				GAAGGGAGGCAGCTTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20609724060374049					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571310	19571360	21991349	21991399	13095	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-38				CTTGTGGTTGGGGGTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.98540036178166224					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571011	19571061	21991050	21991100	13096	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-39				GGAGGGTGGGAGTGGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.465874430232329					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571342	19571392	21991381	21991431	13097	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-4				GCCCAAGGGAATCCCTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036624234046160511					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570795	19570845	21990834	21990884	13098	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-40				GAGAATAATGTGAACCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95777119527807542					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19570829	19570879	21990868	21990918	13099	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-41				TCCCGAGTAGCTGGAACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1646444626403958					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571172	19571222	21991211	21991261	13100	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-5				GGTGTGGAGGTATTGTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.097895594451241					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571328	19571378	21991367	21991417	13101	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-6				GGTGGTGAGAGTCGGCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14497467889782131					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571426	19571476	21991465	21991515	13102	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-7				TTGAGATGCCCAAGATGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1466483620573874					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571577	19571627	21991616	21991666	13103	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-8				TCCGTGGGCACATCAGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12206090124486681					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19571487	19571537	21991526	21991576	13104	hg38	N/A	enh17586	N/A	Enhatls82547	enhancer	GATA6e+11-9				TCACCAGCAGGGACTTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87197624551741137					MIB1	chr18	21740791	21870953	117852				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514954	19515004	21934993	21935043	13105	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-1				AAAGCGTGGCTCCGTAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4271577243985671					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514939	19514989	21934978	21935028	13106	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-10				CACGCTTTAGCCCACCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7902443939553732					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514381	19514431	21934420	21934470	13107	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-11				AACGGTCATTTGATCTGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3819935620134649					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514819	19514869	21934858	21934908	13108	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-12				AACCCAAAGCTAATCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.92624186300766					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514209	19514259	21934248	21934298	13109	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-13				GCTAATCTAACCTCACTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.09976798637886					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515160	19515210	21935199	21935249	13110	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-14				GTTTGAAATCACCCGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.430295009320842					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514227	19514277	21934266	21934316	13111	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-15				TTCAACTGAGGCAGGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.186922390408077					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515220	19515270	21935259	21935309	13112	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-16				CCCCGACAGGGCCTTTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2335095700964138					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514268	19514318	21934307	21934357	13113	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-17				CGGCTGTTGTATATGTAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.632571956474496					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515238	19515288	21935277	21935327	13114	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-18				GAGGGCGCCTGGGTGATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.08009656648249					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515143	19515193	21935182	21935232	13115	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-19				CATTTCTGGAGATGCTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7723313469385862					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514113	19514163	21934152	21934202	13116	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-2				AGATTGGACCCAACTTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4141234802290672					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514409	19514459	21934448	21934498	13117	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-20				AAAATTTGGTACATCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.008766003062759					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515257	19515307	21935296	21935346	13118	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-21				CTGGAAGCCTCCCCACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.14568973552919					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515034	19515084	21935073	21935123	13119	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-22				ACACACACAAGTCTTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6795086759335911					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514928	19514978	21934967	21935017	13120	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-23				CTCAAAGGCACCCTTCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5394723003088169					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515106	19515156	21935145	21935195	13121	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-24				ACTCCCCGGTCTGAGGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.25567664968291					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513905	19513955	21933944	21933994	13122	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-25				CAATGGCTCCTCCAGACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.038570172363444					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514770	19514820	21934809	21934859	13123	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-26				AGCGCCAGACTCTCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8781406144100838					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514314	19514364	21934353	21934403	13124	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-27				TTACTCTCACCTGCCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1460789358838448					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514289	19514339	21934328	21934378	13125	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-28				GGCTGTGCTGGTCAGTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8230802160623849					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514981	19515031	21935020	21935070	13126	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-29				GGTAGCTTTTCTGGAGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3430614972704391					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515208	19515258	21935247	21935297	13127	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-3				AGCACAACTTAGCCCCGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.122617657138516					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514965	19515015	21935004	21935054	13128	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-30				AGCTACCATTTCCTCCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0998140994040111					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515047	19515097	21935086	21935136	13129	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-31				TTGCTCAGGGGGACATAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44805865799380329					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514129	19514179	21934168	21934218	13130	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-32				ATTTGCATCTCTTAGTAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7983039205311651					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514056	19514106	21934095	21934145	13131	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-33				CCTTAGGTCCTTGGCAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3270333896331339					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514720	19514770	21934759	21934809	13132	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-34				TGAAGGCTGTCTCCCACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.009919974819633					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515065	19515115	21935104	21935154	13133	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-35				TCTGACACTGTAAGAGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6272735832918648					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514599	19514649	21934638	21934688	13134	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-36				GAGGTGGTTGTCAGTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5927270065326229					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514443	19514493	21934482	21934532	13135	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-37				AATAACTGCCAAATTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15885686125998311					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514622	19514672	21934661	21934711	13136	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-38				GTGCTAGTGATTTTCTGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.995787099683819					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514256	19514306	21934295	21934345	13137	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-39				TACAACAGCCGCTGAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5011284702352579					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514515	19514565	21934554	21934604	13138	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-4				GCCTTTTACGAATCCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8699718746941651					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514733	19514783	21934772	21934822	13139	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-40				GAATGAGCTGACACCTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9384055650690648					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514088	19514138	21934127	21934177	13140	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-41				CAGTAGAGATGTGAGGGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4561197430590722					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514040	19514090	21934079	21934129	13141	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-42				TGCTCTAATCCAGCTTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7982372204013171					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513894	19513944	21933933	21933983	13142	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-43				TGAGAATGAGCCCCTTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1075091953810978					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514757	19514807	21934796	21934846	13143	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-44				TTCTTCCAACTGACCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8612648883702678					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514802	19514852	21934841	21934891	13144	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-45				TGGGTTCACTCTGTCTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5459659450270231					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514392	19514442	21934431	21934481	13145	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-46				GATCTGACCAGGAAAGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6190618414068041					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513871	19513921	21933910	21933960	13146	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-47				GCTAGAAGCAGCATGTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2899526526727878					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514571	19514621	21934610	21934660	13147	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-48				AGAGAAGGCCTCAAACCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9429890150407232					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514650	19514700	21934689	21934739	13148	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-49				GTCACCTGGGGCCTTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.574202405219431					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514358	19514408	21934397	21934447	13149	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-5				TCGCTGAGACCTTTAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1103696038733259					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513934	19513984	21933973	21934023	13150	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-50				GAAATGACAGCCCCACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.52680709696423					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515092	19515142	21935131	21935181	13151	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-51				CAAAGCATCTTCACACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6121723348689811					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514636	19514686	21934675	21934725	13152	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-52				CTGACAAGGTGTCTGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.726146683777483					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515123	19515173	21935162	21935212	13153	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-53				ATGACTTCAAAGTTCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1972828546707168					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513977	19514027	21934016	21934066	13154	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-54				CTGTTCAGGTTCAACCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5304976506744978					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514009	19514059	21934048	21934098	13155	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-55				AAAGCACATGCAAATCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6458431995131209					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514914	19514964	21934953	21935003	13156	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-56				GCCTTTGAGGAGGAGGACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5459611617721833					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513919	19513969	21933958	21934008	13157	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-57				GAGCCATTGTTTCTCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0608363217303118					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514848	19514898	21934887	21934937	13158	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-58				CAGATAAGCCCCAGTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9956945172208158					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513950	19514000	21933989	21934039	13159	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-59				TCATTTCCACTCTGCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.332847685244603					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514835	19514885	21934874	21934924	13160	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-6				GGCTTATCTGCGACATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6902310626722521					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514179	19514229	21934218	21934268	13161	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-60				CTCTGCTAATTCTCTGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.857964188531056					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514502	19514552	21934541	21934591	13162	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-61				AGTGGCAGCCCTTCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9928547536049082					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513991	19514041	21934030	21934080	13163	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-62				CCTGAACAGAAGAAAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6097595561467819					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514586	19514636	21934625	21934675	13164	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-63				CAACCACCTCTCTCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.634875210055633					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514331	19514381	21934370	21934420	13165	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-64				ATTACCTGCCACCCCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.827468928063678					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514423	19514473	21934462	21934512	13166	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-65				ATTCTAAAGTGGCTAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8589230800101468					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514903	19514953	21934942	21934992	13167	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-66				GGAGGACATGGGCTGACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.31912906975958					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514478	19514528	21934517	21934567	13168	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-67				GTGTACGAAGGGGCAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1759273303207389					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19515020	19515070	21935059	21935109	13169	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-68				TGTGTGTGTGAAATCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3833694015720011					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514661	19514711	21934700	21934750	13170	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-69				GCAGGCTGCATCCCACAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5372341121448532					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514708	19514758	21934747	21934797	13171	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-7				GACAGCCTTCACGAGGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3783792299388979					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514683	19514733	21934722	21934772	13172	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-70				AGGGCAGAGAGTCCACAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1952211409898088					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514875	19514925	21934914	21934964	13173	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-71				TGGCCTCCTTTACCTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2172835672302771					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513963	19514013	21934002	21934052	13174	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-72				GCAGCCAGGGAGAGCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3696635307537379					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513841	19513891	21933880	21933930	13175	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-73				TCTGAACTCATAGATATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.727351489983092					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514559	19514609	21934598	21934648	13176	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-74				AAACCCTGGGGTGGGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6538022356540729					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514537	19514587	21934576	21934626	13177	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-75				GAGAGAGGCTGGGACACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3711162642923518					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514156	19514206	21934195	21934245	13178	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-76				AAATAAACACTAAAACAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.763389278713029					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514548	19514598	21934587	21934637	13179	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-77				TGGGGCAGCTGGAGAGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8442134078449919					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514887	19514937	21934926	21934976	13180	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-78				CAGGAGGCAGAGCCAGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0552158638025939					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513794	19513844	21933833	21933883	13181	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-79				TTTGTTTTGTTTTTTGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0554987896012169					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514239	19514289	21934278	21934328	13182	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-8				ATGCGGCCTTTGTTCAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9685911263603688					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513770	19513820	21933809	21933859	13183	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-80				TCTCACTATGTTGCCCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.83376218571514					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19513757	19513807	21933796	21933846	13184	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-81				CAGGAGTTTGAGACCAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6172897950455369					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19514466	19514516	21934505	21934555	13185	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+12-9				ACAAAAGGGCCAGTGTACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7430895414571128					MIB1	chr18	21740791	21870953	61602				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76909	chr18	19315630	19315680	21735669	21735719	13186	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-1				GATGCTCAAGCTTGGTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35468224970802309					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315870	19315920	21735909	21735959	13187	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-10				GGGACAGAGTATCTGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7068651631133539					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316063	19316113	21736102	21736152	13188	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-11				CTCCTGTATGAGGTGTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.295102354312738					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315525	19315575	21735564	21735614	13189	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-12				ACCCGCTGAGCCAGACCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036802922064213282					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315549	19315599	21735588	21735638	13190	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-13				CTTGCTGGGCTCTGTGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53943724425629958					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315833	19315883	21735872	21735922	13191	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-14				TTTATCTATAAGTGCCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0625095876144759					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315664	19315714	21735703	21735753	13192	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-15				GCCTACGCAAGCCTCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22440878110878931					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315929	19315979	21735968	21736018	13193	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-16				CTCTTCACAGGTGTCAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34244036430586611					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316075	19316125	21736114	21736164	13194	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-17				TCATACAGGAGAGCACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49135659135086029					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315698	19315748	21735737	21735787	13195	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-18				CACAGTGTAAACAAAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14689012979420341					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316038	19316088	21736077	21736127	13196	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-19				ACAGGGAGACACCTCCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057568128589336867					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315718	19315768	21735757	21735807	13197	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-2				CGGAAGTTCGAACTGGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.098049266302292853					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315653	19315703	21735692	21735742	13198	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-20				AGGGGCATCCGCCATTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55242446530117184					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315802	19315852	21735841	21735891	13199	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-21				GCAGGGCATCTCTGAAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.98149686003724645					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315579	19315629	21735618	21735668	13200	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-22				CAGCGAGAATTTCAAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042204962433562532					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315819	19315869	21735858	21735908	13201	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-23				AAAAGGCAGCAGCCCCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3432041516440284					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315784	19315834	21735823	21735873	13202	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-24				TAGATTCCTCCTCTCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1145765604144854					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316005	19316055	21736044	21736094	13203	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-25				GGGGGTCAAGGACCCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1650180864783479					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315770	19315820	21735809	21735859	13204	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-26				AGGAATCTAGAGAGGCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.684814664851911					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315564	19315614	21735603	21735653	13205	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-27				GCCAGTGGATCTTAGCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16656113782880419					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315992	19316042	21736031	21736081	13206	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-28				GGACAGACTGCTTCCTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43110616789687789					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316049	19316099	21736088	21736138	13207	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-29				GTCTGTCGGCCCCTACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.642346051930472					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315941	19315991	21735980	21736030	13208	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-3				AGATCCACTGCTCTCTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34948857025579422					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315741	19315791	21735780	21735830	13209	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-4				TGTCATTGCTGAGTTGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08306454586718004					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315598	19315648	21735637	21735687	13210	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-5				GCTGCTAGCACAGCAGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13724861752167411					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315857	19315907	21735896	21735946	13211	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-6				ACTCTGTCCCAGGGAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2019229642708611					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19316024	19316074	21736063	21736113	13212	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-7				TCTCCCTGTTAGGATACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3326087027014295					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315970	19316020	21736009	21736059	13213	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-8				ACAGCGTTCGAGCTCTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.058691452385530821					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76909	chr18	19315881	19315931	21735920	21735970	13214	hg38	N/A	enh17585	N/A	Enhatls82525	enhancer	GATA6e+13-9				TCTGGGGGAAGGGGCAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.994701296576352					MIB1	chr18	21740791	21870953	4465				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	927
enhrx-76859	chr18	18967074	18967124	21387113	21387163	13215	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-1				TAGGTTCCTACCCTGCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.149695022999736					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966764	18966814	21386803	21386853	13216	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-10				AGTTCAATTGAAAGAGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.627428480672136					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966910	18966960	21386949	21386999	13217	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-11				AAATAGAGGATTTCCCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80934984273984123					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966803	18966853	21386842	21386892	13218	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-12				TAAGAGCCTTCTTACTCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59577939507483424					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967127	18967177	21387166	21387216	13219	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-13				GTATTTGGAGGCCTAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26639110907117769					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967142	18967192	21387181	21387231	13220	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-14				AGAGTAATCAAAGCAGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63217902565313333					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967204	18967254	21387243	21387293	13221	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-15				GTTACAGAGTAAACTAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83169628150679764					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966924	18966974	21386963	21387013	13222	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-16				TTTGAGCCTTAAGTAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096113733435828561					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967017	18967067	21387056	21387106	13223	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-17				TACCATTCAGATGTAAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.394653066005622					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966848	18966898	21386887	21386937	13224	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-18				TATGAAAATGGCAGTGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.067000957972011346					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966948	18966998	21386987	21387037	13225	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-19				AAAGGTAAAGCTATTTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0293967557870216					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967055	18967105	21387094	21387144	13226	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-2				GTAAATTATCGGAGTAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057410778796717438					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966836	18966886	21386875	21386925	13227	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-20				TGAAATTTTCCTTATGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30376967538513833					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967044	18967094	21387083	21387133	13228	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-21				TAATTTCTTATGTAAATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-8.92126022190515					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966663	18966713	21386702	21386752	13229	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-22				GACCATCCTGGCTAACACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80990820101542815					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966751	18966801	21386790	21386840	13230	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-23				GAGCTACTGGCTGGGCGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6007153930143581					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966693	18966743	21386732	21386782	13231	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-24				GGCAGGCGGATCACGAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01950099710763149					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966724	18966774	21386763	21386813	13232	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-25				CGCCTGTAATCCTAGCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1039767533398388					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966675	18966725	21386714	21386764	13233	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-26				TCAGGAGATCTAGACCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.75787710920868					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966637	18966687	21386676	21386726	13234	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-27				TATGTATTTTTAGTAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966707	18966757	21386746	21386796	13235	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-28				CTTTGGGAGGCCGAGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.02462721805385					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966897	18966947	21386936	21386986	13236	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-3				GCATACCACCTTCCCTTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31315963685156878					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966882	18966932	21386921	21386971	13237	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-4				TGGTATGCTTATTTAGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43121062852767289					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18966992	18967042	21387031	21387081	13238	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-5				TAACACCTGATGGGCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2084065920492397					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967092	18967142	21387131	21387181	13239	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-6				GGAGGCAGTTGATTGTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82226305098995867					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967161	18967211	21387200	21387250	13240	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-7				CTCTAGTTTGTGTTTATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15966502369073571					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967225	18967275	21387264	21387314	13241	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-8				ACCTTCAAGTTGGAGATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68063655802330847					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76859	chr18	18967108	18967158	21387147	21387197	13242	hg38	N/A	N/A	N/A	Enhatls82473	enhancer	GATA6e+14-9				TTGGTTGTCCTTTACCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37614630929143023					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	877
enhrx-76856	chr18	18924791	18924841	21344830	21344880	13243	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-1				GCGATCACCAACTCAAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29575387788026458					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924885	18924935	21344924	21344974	13244	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-10				AGGCAGTCAAAGATATAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5183593237056594					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924867	18924917	21344906	21344956	13245	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-11				TTAGGTCACATTTAGGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30564947633785577					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925095	18925145	21345134	21345184	13246	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-12				AGTGCAAGGGAACCCAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11405946768735629					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925134	18925184	21345173	21345223	13247	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-13				TACTGCTGGATATTTCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31339536843743621					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924981	18925031	21345020	21345070	13248	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-14				CAGCCTGCTGAGAAAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85763458318271535					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924998	18925048	21345037	21345087	13249	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-15				AGGCTGCTCCTCTCACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18048588466373111					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925149	18925199	21345188	21345238	13250	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-16				ATGGCTGTGAAACAACCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25869900291672782					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924957	18925007	21344996	21345046	13251	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-17				GGGTACAGGCTTGAAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.749728054123614					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924924	18924974	21344963	21345013	13252	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-18				GAATAATTGATTAGATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3070630160728229					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924905	18924955	21344944	21344994	13253	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-19				AAGGAAAGGAACTCAGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.441710833279169					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925108	18925158	21345147	21345197	13254	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-2				TAATAGGGTCTGAAGTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32203082725211207					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18924946	18924996	21344985	21345035	13255	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-20				TGAAGAGAGTGGAATAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56501456323338473					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925123	18925173	21345162	21345212	13256	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-3				TATCCAGCAGTAATCTAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.079800069975589					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925062	18925112	21345101	21345151	13257	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-4				CTTGGCTTCACTAGTACTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19723455200971979					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925025	18925075	21345064	21345114	13258	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-5				GGCAATTAATGGGACTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1454622360110033					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925046	18925096	21345085	21345135	13259	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-6				CTTAGGGTCAGCTAAAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14653662536414869					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925168	18925218	21345207	21345257	13260	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-7				TAGACATATGGTTTTCGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97800959519272423					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925180	18925230	21345219	21345269	13261	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-8				CCATATGTCTAAGAACTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.161928432742851					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18925083	18925133	21345122	21345172	13262	hg38	N/A	N/A	N/A	Enhatls82470	enhancer	GATA6e+15-9				AGTTCTTTATCTCCAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25403377850166409					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885708	18885758	21305747	21305797	13263	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-1				TAGCTAGATACCAGACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33493880993947323					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885759	18885809	21305798	21305848	13264	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-10				TCAGAAGGCCAGTAAGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66179421185185483					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885576	18885626	21305615	21305665	13265	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-11				TTGCATGAAGAATAGACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54802259953274324					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885798	18885848	21305837	21305887	13266	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-12				CCCAGCTCATTCCCAGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25241529191346562					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885905	18885955	21305944	21305994	13267	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-13				CTCTGAGGAGTTGACATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25362083265469282					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885731	18885781	21305770	21305820	13268	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-14				GATAGGAGATAAGACAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5410852131940953					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885664	18885714	21305703	21305753	13269	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-15				AGATTTTGTTCCAAGAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29703564676583588					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885787	18885837	21305826	21305876	13270	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-16				GAATGAGCTGGGCAGGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.046642692377807472					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885601	18885651	21305640	21305690	13271	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-17				CTGCTTTAAAAGAATCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60548228309159713					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885748	18885798	21305787	21305837	13272	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-18				GTAAGTGAAAGGAAAGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57700759054072726					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885931	18885981	21305970	21306020	13273	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-19				TTAGATGAGATGTTCAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.326358296282776					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885649	18885699	21305688	21305738	13274	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-2				AGTGATGGGAAGTTGCCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.162524074633212					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885861	18885911	21305900	21305950	13275	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-20				AAGTCAGCCATGTGAAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040657590314963271					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885844	18885894	21305883	21305933	13276	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-21				ATCTGGGGAAAGAGTATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26052771188143858					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885920	18885970	21305959	21306009	13277	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-22				GTTCAGGGAAGGCCTCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64697300995303764					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885810	18885860	21305849	21305899	13278	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-3				CTAAGATAAAAGCCCCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.345407963475306					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885638	18885688	21305677	21305727	13279	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-4				GTTGCCATAGGGTTTTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40039083182465318					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885541	18885591	21305580	21305630	13280	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-5				ATTGTAGTCAGTCAAGTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.088230717172300327					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885826	18885876	21305865	21305915	13281	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-6				ATCTTAGCTGATCTTTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1003963722115719					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885693	18885743	21305732	21305782	13282	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-7				TTTGCCCTGTGAGACCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6653887625378555					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885887	18885937	21305926	21305976	13283	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-8				TTAGGAAAGACTTGAACAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64655880142156363					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18885774	18885824	21305813	21305863	13284	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+16-9				AGGCTTGGGGAATAGTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35465595388410032					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880760	18880810	21300799	21300849	13285	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-1				CACACACCATCCGTGTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.397073887819436					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881172	18881222	21301211	21301261	13286	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-10				TCTAACAATGCACATAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13425931982142039					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881004	18881054	21301043	21301093	13287	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-11				CATGATGCTTTCTGTGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23221406525331931					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880985	18881035	21301024	21301074	13288	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-12				CATGCTACTGAATTAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36299346939383342					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881223	18881273	21301262	21301312	13289	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-13				GCTTTGTAAAACTTAACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076691197076379183					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881254	18881304	21301293	21301343	13290	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-14				CTTGGCTTTCCTTGAGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33779398350351852					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880919	18880969	21300958	21301008	13291	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-15				GAAAGACTCAAACTTCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.021286876834990032					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880740	18880790	21300779	21300829	13292	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-16				GTGTGTCCTGTTGGGGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27524797828749392					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880957	18881007	21300996	21301046	13293	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-17				GTCTGTGATGTTTATCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30425988624337408					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880941	18880991	21300980	21301030	13294	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-18				CACAGACATCAAGAAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.328956556595475					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881138	18881188	21301177	21301227	13295	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-19				TTATTTCATGGCTTCTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.215812299504105					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881043	18881093	21301082	21301132	13296	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-2				ATATCTGGCAGGATGCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34492585946228432					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881126	18881176	21301165	21301215	13297	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-20				ATAATTTGCCATTTATTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.358768207683589					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880700	18880750	21300739	21300789	13298	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-21				TCAAGAAAAGATGATGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5559467833058851					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880771	18880821	21300810	21300860	13299	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-22				CGTGTGTGAGGGGTGGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30569320423255292					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880729	18880779	21300768	21300818	13300	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-23				TGGGGAAGAAGGGGTGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45617520548919338					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880688	18880738	21300727	21300777	13301	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-24				GATGAAAAAGGAAAGAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84186480709115252					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881189	18881239	21301228	21301278	13302	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-3				GTTAGAGTGAAGCTGACAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47218260539704349					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881236	18881286	21301275	21301325	13303	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-4				TAACAGGAGGAGGCCATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43368295977810378					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880855	18880905	21300894	21300944	13304	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-5				GCCTCCCTGAAAGTAAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51403241455537541					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881032	18881082	21301071	21301121	13305	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-6				GAGAGTGTTTGATATCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.065974164967856					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880804	18880854	21300843	21300893	13306	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-7				TAATGTGATCTTGTTCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1230113353393716					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18880904	18880954	21300943	21300993	13307	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-8				CATGCCTCACATGTGCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042979472247892649					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76856	chr18	18881085	18881135	21301124	21301174	13308	hg38	N/A	enh58793	N/A	Enhatls82470	enhancer	GATA6e+17-9				ATGCTTCTAAGACAACATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12927108820390709					GREB1L	chr18	21242231	21526112	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	874
enhrx-76933	chr18	19690709	19690759	22110748	22110798	13309	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-1				GAGCCATCTGTGCGATAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087680618925618223					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690659	19690709	22110698	22110748	13310	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-10				TCCGCTGCTGACTGCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00289694031334741					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690645	19690695	22110684	22110734	13311	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-11				ATTAGAAGGAGGTACCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54963683393888174					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690804	19690854	22110843	22110893	13312	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-12				GACTGTTTGCTGTGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0225080374453002					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690752	19690802	22110791	22110841	13313	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-13				GAGCCTTCCCACCTCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29235758354791191					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690855	19690905	22110894	22110944	13314	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-14				GGAATGGGAAAGATCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63816543924157121					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690545	19690595	22110584	22110634	13315	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-15				CTTTCTGCCTTGTCATGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12472144694541561					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690780	19690830	22110819	22110869	13316	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-16				AGTTCCCTCCACAGGGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82398577902849079					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690590	19690640	22110629	22110679	13317	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-17				GGCAGTTTACAGAATGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.481416916719257					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690763	19690813	22110802	22110852	13318	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-18				GGAACTCAGGGCCTGCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1533248092709849					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690449	19690499	22110488	22110538	13319	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-19				GACTTTGAGCCAGGTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30764154982084357					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690696	19690746	22110735	22110785	13320	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-2				CAGATGGCTCTCTCACCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46240299463348339					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690467	19690517	22110506	22110556	13321	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-20				AAGTCAGCCAGAGCCTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1168579310182815					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690418	19690468	22110457	22110507	13322	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-21				TGGTATATTCCTTCTGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21686229212790409					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690532	19690582	22110571	22110621	13323	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-22				CATGCTCTGGGGCAGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77757048212942359					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690491	19690541	22110530	22110580	13324	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-23				GTGGCTCACGTGGGGGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7549652931929272					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690681	19690731	22110720	22110770	13325	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-24				AGTGGACTGAACGAGCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38688940267356858					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690431	19690481	22110470	22110520	13326	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-25				CTGTCTCTGGTCCTGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5016197000742072					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690818	19690868	22110857	22110907	13327	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-3				TCTGAATTGTTAATCCGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.116877663079005					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690516	19690566	22110555	22110605	13328	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-4				GGGAGAGTTCCAACCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69877581654903609					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690634	19690684	22110673	22110723	13329	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-5				GTCACAATCCTATTAGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55606178281973628					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690721	19690771	22110760	22110810	13330	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-6				CGATAATGAGGTTCTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23581651701772419					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690480	19690530	22110519	22110569	13331	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-7				CACGTGAGCCACACCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0247747658176329					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690607	19690657	22110646	22110696	13332	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-8				ACTGCCCAAGTAACTTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7666222886749996					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19690573	19690623	22110612	22110662	13333	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+2-9				AGGAGGTTTACTAGGTGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060156833979726231					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686762	19686812	22106801	22106851	13334	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-1				TGACTCACTTAGCCCGTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44785138368959387					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686521	19686571	22106560	22106610	13335	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-10				CAAGGGACAACAAGACAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.208029739832767					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686475	19686525	22106514	22106564	13336	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-11				GATACAAGCAAATACATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99174739878103824					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686750	19686800	22106789	22106839	13337	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-12				TTGGAAGCTGAGCCATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02910263652911603					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686559	19686609	22106598	22106648	13338	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-13				CTCAGCTCACAGCTTCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.236033634814754					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686827	19686877	22106866	22106916	13339	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-14				GGTAAAAGAAGGCAGTTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.357485085641657					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686584	19686634	22106623	22106673	13340	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-15				ACATAAATCAGGTGTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24456615255841391					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686838	19686888	22106877	22106927	13341	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-16				AAAGCTGGCAAGGTAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31812514620612881					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686731	19686781	22106770	22106820	13342	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-17				CTGGCTAATTTGTAGAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082678329164588019					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686815	19686865	22106854	22106904	13343	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-18				CAGTTTGGAGGCTGAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35705688646686118					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686804	19686854	22106843	22106893	13344	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-19				CTGAGCTGCAGGGTGACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75509039250800325					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686686	19686736	22106725	22106775	13345	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-2				CCTGGATCTGATTACCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1045614771107579					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686893	19686943	22106932	22106982	13346	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-20				TTTATAAAATTATAGTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.421537025648562					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686700	19686750	22106739	22106789	13347	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-21				AAACACCAGCCCAGCCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43606259912420819					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686595	19686645	22106634	22106684	13348	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-22				GGTGGATACAAACATAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26885790950808047					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686662	19686712	22106701	22106751	13349	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-3				GAGCCAGCTGATAACATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.923915598416161					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686712	19686762	22106751	22106801	13350	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-4				GGCTGGTGTTTAATACTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3139556487755939					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686628	19686678	22106667	22106717	13351	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-5				AACACTGAAGGCTTACTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1496997732435417					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686853	19686903	22106892	22106942	13352	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-6				TCATTAGATTTGGGCAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41671316624295612					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686538	19686588	22106577	22106627	13353	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-7				GGCAGCAGAGACATATACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33528054141265212					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686644	19686694	22106683	22106733	13354	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-8				CAGTGTTTTGATAGAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0710702794176556					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19686616	19686666	22106655	22106705	13355	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+3-9				TTACTATGAGGCAATGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80855031148644607					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682123	19682173	22102162	22102212	13356	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-1				ACAGTCTAGCGCACCTTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.478014593981922					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681701	19681751	22101740	22101790	13357	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-10				TGTAGGTTCCTGCAAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83914746571578669					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681940	19681990	22101979	22102029	13358	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-11				GCCCTTAGATTAGGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.254846405239235					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681793	19681843	22101832	22101882	13359	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-12				AGCCAGACTTTGCATATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41688661704750551					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681768	19681818	22101807	22101857	13360	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-13				GAATATTCCAAGGGTGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3509940136816461					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681893	19681943	22101932	22101982	13361	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-14				AGTGGTCTCTGAACGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1429766111367039					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681675	19681725	22101714	22101764	13362	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-15				ATGACAAGTGTTCTTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.345728420511477					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681985	19682035	22102024	22102074	13363	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-16				GACTGCAAAAAACCAAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87618135592642565					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681962	19682012	22102001	22102051	13364	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-17				TTCATCTGTAGTGTCATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1363848789693329					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682066	19682116	22102105	22102155	13365	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-18				GAAATCATTATAGGATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9619332229778721					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682084	19682134	22102123	22102173	13366	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-19				GACAGAAGAAGAGCATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9964736278132751					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681922	19681972	22101961	22102011	13367	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-2				GGGGGTATTGTTGTCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3154789643828131					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682016	19682066	22102055	22102105	13368	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-20				AGGGAGGGCCAGCATCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.650028283059243					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682110	19682160	22102149	22102199	13369	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-21				ACTCCCACCCTCACCTACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.35002123503302					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681875	19681925	22101914	22101964	13370	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-22				AAGGGATAAGGAAGAGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89802290122425132					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681904	19681954	22101943	22101993	13371	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-23				AACGGAGACAGGAGGTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6308907058991222					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681863	19681913	22101902	22101952	13372	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-24				GGAAGTAGAAATAAGGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.10067425971764					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682159	19682209	22102198	22102248	13373	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-25				AAATAAATTAACCTCTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-11.78642778903291					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681996	19682046	22102035	22102085	13374	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-26				ACCAAGGCCTGGGGTGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7885541077820979					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681718	19681768	22101757	22101807	13375	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-3				CCTACAATTGTGACCGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6233702727234991					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19682033	19682083	22102072	22102122	13376	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-4				CCATGGACCAAGGTCATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3229929907093569					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681847	19681897	22101886	22101936	13377	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-5				TACTTCCTCTCGGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83378816591383909					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681746	19681796	22101785	22101835	13378	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-6				CACCTCCATAATCCACTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3116506043250742					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681821	19681871	22101860	22101910	13379	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-7				TGCAGATATGCTTATCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99034835839173041					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681832	19681882	22101871	22101921	13380	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-8				TTATCAGACCGGAATCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9108829809693779					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19681731	19681781	22101770	22101820	13381	hg38	N/A	enh52643	N/A	Enhatls82547	enhancer	GATA6e+4-9				CTAACTGGCCTGTCCCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.306826217822747					GATA6	chr18	22169588	22202528	51795				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674247	19674297	22094286	22094336	13382	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-1				CAATCGGTAAAGAGTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39486479197548879					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673921	19673971	22093960	22094010	13383	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-10				CTATCTGTCCGCCTGACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51124686934856856					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674771	19674821	22094810	22094860	13384	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-11				CTGGACAGGCAATTTTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020326264714284361					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674664	19674714	22094703	22094753	13385	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-12				TGCTAAACGCTTTTTGCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1025108197164169					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674463	19674513	22094502	22094552	13386	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-13				ATTAGACTTGTCAACAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42588615649589517					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674851	19674901	22094890	22094940	13387	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-14				AAGGACGCCCTCCCCCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87075563066296213					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674974	19675024	22095013	22095063	13388	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-15				GACAAGGGAGGACCAATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60681978157578231					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674294	19674344	22094333	22094383	13389	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-16				AGCCTAAACTTTTTGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58381685972403263					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674322	19674372	22094361	22094411	13390	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-17				TCACAATATTCCCCTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92087398480774285					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674392	19674442	22094431	22094481	13391	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-18				ACCCAGAGAGATGTTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12784258012323191					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674962	19675012	22095001	22095051	13392	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-19				ACTGAGTTATTAGACAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6588206967103627					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674474	19674524	22094513	22094563	13393	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-2				GACAAGTCTAATACCCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77864943507828055					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674891	19674941	22094930	22094980	13394	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-20				TGAATGTGAGAAGTAGCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82433095454135363					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674336	19674386	22094375	22094425	13395	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-21				TCCAGTGGGTCTCTACCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9943839044128322					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674139	19674189	22094178	22094228	13396	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-22				CTGGCCGGCTCCACAAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.711586986552592					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674034	19674084	22094073	22094123	13397	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-23				AGGTTCCCGGAGGGACAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94489257701003126					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674628	19674678	22094667	22094717	13398	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-24				TGAACATTGCACCTTCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54135005730954255					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674022	19674072	22094061	22094111	13399	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-25				TCCGGGAACCTCATTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2369233134589204					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674050	19674100	22094089	22094139	13400	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-26				AAGCAGGCAGCTACGATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1583929499956409					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674545	19674595	22094584	22094634	13401	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-27				CTGCGAGCTGCTGTTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11429298556527739					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674190	19674240	22094229	22094279	13402	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-28				GGTGTCTGACAAGAACAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9010888812659017					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674445	19674495	22094484	22094534	13403	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-29				GGAGGCAGTCTCTACAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.084978712545841					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674153	19674203	22094192	22094242	13404	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-3				GCCGGCCAGACTTTGTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092170166701865286					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674757	19674807	22094796	22094846	13405	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-30				TTATCAGGGCTCACTGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17453726909991041					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674209	19674259	22094248	22094298	13406	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-31				AAGGAAGAGGTAGATCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097035499381957033					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674556	19674606	22094595	22094645	13407	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-32				AGCAGCTCGCAGCTCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44517968428374832					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673858	19673908	22093897	22093947	13408	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-33				TTATCAAGAAAGCTCAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7221447054345016					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673932	19673982	22093971	22094021	13409	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-34				CAATAGAAAGTCCAAATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27352860912161941					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674408	19674458	22094447	22094497	13410	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-35				GTCATAAACTTGGAAACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050436434599989963					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674580	19674630	22094619	22094669	13411	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-36				GGGAGTTGTTAGCAAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020633051346174339					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674597	19674647	22094636	22094686	13412	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-37				GCAAGGCCTTGTGAAGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98209311468073146					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674165	19674215	22094204	22094254	13413	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-38				TTGTTGGCTGGGGGGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2027660935641272					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673802	19673852	22093841	22093891	13414	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-39				AATATGCATGATTTGGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25662142568101431					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673838	19673888	22093877	22093927	13415	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-4				TAACTGAATCGGATGACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060062338938797928					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674281	19674331	22094320	22094370	13416	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-40				TGTCCCTTGGAGTGGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.512090673961311					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673718	19673768	22093757	22093807	13417	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-41				AGTAAGTTTAATTTGACCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41730417167201328					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673974	19674024	22094013	22094063	13418	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-42				GTGATCTGGGGTGGGCGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90586890279542343					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674785	19674835	22094824	22094874	13419	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-43				ATGCTTTCCTTCCCCTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1811741270438805					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674486	19674536	22094525	22094575	13420	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-44				ACCCATGCTGGGTGGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3568254975610108					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674529	19674579	22094568	22094618	13421	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-45				AGAGAATCCCCCAGAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13976435702146381					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674912	19674962	22094951	22095001	13422	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-46				CAGCTTTGGGGTAAAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74603797283251394					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673987	19674037	22094026	22094076	13423	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-47				GAGAAACTTAAAAGTGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.238021737393419					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673875	19673925	22093914	22093964	13424	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-48				AATTGGGCAGGGAACAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0516159071931358					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674613	19674663	22094652	22094702	13425	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-49				GCTCTGGGGTGGTTGCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71745135624178757					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674685	19674735	22094724	22094774	13426	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-5				CAGCCGTCTGACTGATCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26240653101752759					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674098	19674148	22094137	22094187	13427	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-50				CTCTTATCTCCACCACCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.060014714574297343					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674870	19674920	22094909	22094959	13428	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-51				GGTCAGAGGCAAAAGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28089729372094741					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674820	19674870	22094859	22094909	13429	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-52				AAAGGATTATCCTTTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.8188122002136824					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673734	19673784	22093773	22093823	13430	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-53				ACAAGTTAATAAATTACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23711698641124371					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674837	19674887	22094876	22094926	13431	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-54				TCCTTTCTGTATTTCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3576056877352629					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674006	19674056	22094045	22094095	13432	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-55				TCTCTGTTCTCAAATTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.023215729948575639					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674263	19674313	22094302	22094352	13433	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-56				AAAGGGAAGAATTGAGCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59283975396655608					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674727	19674777	22094766	22094816	13434	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-57				TGCTACTGTCTTGACTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.354214094578115					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674127	19674177	22094166	22094216	13435	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-58				ACAAGGCAGGGCTGGGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64860720545608375					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19673959	19674009	22093998	22094048	13436	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-6				CGAAAAGGTGTAATCTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.031864303737396162					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674084	19674134	22094123	22094173	13437	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-7				ACCTTCTGGTGTGGAGAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21971881776392521					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674502	19674552	22094541	22094591	13438	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-8				GGCGAGGGGCAAAGATAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25716942389188541					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19674360	19674410	22094399	22094449	13439	hg38	N/A	enh91192	N/A	Enhatls82547	enhancer	GATA6e+5-9				GACTCCACAGCTGTATAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070628267019004445					GATA6	chr18	22169588	22202528	72995				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664790	19664840	22084829	22084879	13440	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-1				ATGGCGTTGAAACCCTGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4177692970138478					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664658	19664708	22084697	22084747	13441	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-10				GTCGAGTTGGAACAAAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30417578585173638					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664826	19664876	22084865	22084915	13442	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-11				CCATGAAACGACCTCATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13194928933024869					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664695	19664745	22084734	22084784	13443	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-12				CGTTGGATAATCTTTAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60749144294029478					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664995	19665045	22085034	22085084	13444	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-13				TAGGGAAGTGTAAATCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52553954346404486					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664902	19664952	22084941	22084991	13445	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-14				AATTTGGTCATTGTTGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.799000129485773					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664976	19665026	22085015	22085065	13446	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-15				TCAAGAGGAATAGATCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036466425722836752					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664748	19664798	22084787	22084837	13447	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-16				CAGAGCTGCTTATAGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56382135301619163					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664937	19664987	22084976	22085026	13448	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-17				AGAGTTATAACATGAGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18777947390304059					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19665068	19665118	22085107	22085157	13449	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-18				AGGCAGGAGGGTTTCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0956854582720063					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664837	19664887	22084876	22084926	13450	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-19				AAGTTCATTCCCCTGTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83227828981449314					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664803	19664853	22084842	22084892	13451	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-2				AATGCCACGAGGTCCCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27271129810806288					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19665049	19665099	22085088	22085138	13452	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-20				GCCTTTGCTTCTGCCCAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28070841076317238					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664848	19664898	22084887	22084937	13453	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-21				GGGAATGAACTTTATCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60032721249162568					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664918	19664968	22084957	22085007	13454	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-22				CAGGTTTAATTTAGGAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1581250492642921					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664683	19664733	22084722	22084772	13455	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-23				TTTAACAGAGGAAGACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.029827391652804					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664961	19665011	22085000	22085050	13456	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-24				AATTTCACAATCTCATCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72087680223051687					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664706	19664756	22084745	22084795	13457	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-3				GATTATCCAACGCGTCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49590587209916359					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664776	19664826	22084815	22084865	13458	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-4				CAACGCCATTCAGTTACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0022372407719898888					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664723	19664773	22084762	22084812	13459	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-5				TTATGGGAACGTTGGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15676136650792841					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19665036	19665086	22085075	22085125	13460	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-6				CGGAAGGCTGATTCCCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78049790418811071					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19665020	19665070	22085059	22085109	13461	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-7				TGGCCTTTCAGTGAATCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44956007139686838					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664814	19664864	22084853	22084903	13462	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-8				TCGTTTCATGGAATGCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58818861982161186					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19664645	19664695	22084684	22084734	13463	hg38	N/A	N/A	N/A	Enhatls82547	enhancer	GATA6e+6-9				CTCAAATACGAAAGTCGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32799176913905909					GATA6	chr18	22169588	22202528	77525				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659751	19659801	22079790	22079840	13464	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-1				ACTGGACTCGTGTGCACGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49114183899111319					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659788	19659838	22079827	22079877	13465	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-10				TCCCCAGAACAGACTTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.144255802477544					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659893	19659943	22079932	22079982	13466	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-11				CATCAAAGGGTTTTCTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43490091625096439					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659822	19659872	22079861	22079911	13467	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-12				TGTCTGGCAAGAGAGTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50620164122113376					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659959	19660009	22079998	22080048	13468	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-13				AAAATCCTAATCTAGTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042481568088223821					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660081	19660131	22080120	22080170	13469	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-14				CAAGCTCCACACCTTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.123393309829752					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660039	19660089	22080078	22080128	13470	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-15				ATTTGAAATCAGTGTTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39842655717475528					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660228	19660278	22080267	22080317	13471	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-16				GTGAAACTACAACAAAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45853053656640858					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660003	19660053	22080042	22080092	13472	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-17				CCAAGCCCATTTTTTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22209275451793781					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660285	19660335	22080324	22080374	13473	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-18				GTGCAAAATGTAATTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.122453752184921					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660134	19660184	22080173	22080223	13474	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-19				AAGTGGCCAAGGAAAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.555494455086056					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660092	19660142	22080131	22080181	13475	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-2				CGTGAGACAGACCTTGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84984528513443014					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660316	19660366	22080355	22080405	13476	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-20				TTTACAAAGTCAAGATGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14480928648003369					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660368	19660418	22080407	22080457	13477	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-21				TTACAAATGATCCAGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30204840923043852					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659859	19659909	22079898	22079948	13478	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-22				GTCAAGAGAAAGACAAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50406899259240268					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659976	19660026	22080015	22080065	13479	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-23				GATTTTTCTAACTTTTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42481469370038011					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660379	19660429	22080418	22080468	13480	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-24				ATTTTAAAAATCCATTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.76442079477567					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659879	19659929	22079918	22079968	13481	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-3				GACCTTTTGCTGGTCATCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051859649349830131					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660173	19660223	22080212	22080262	13482	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-4				CACCTTGACAAGTCCCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.106847201165337					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659933	19659983	22079972	22080022	13483	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-5				ACCAACTGAGAGCTGCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80798354099503067					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660159	19660209	22080198	22080248	13484	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-6				ATAGCACTTTCAGCCCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21197349229641191					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660145	19660195	22080184	22080234	13485	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-7				AAGTGCTATCCAAGTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.190479408499826					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19660255	19660305	22080294	22080344	13486	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-8				ACGGAATGTTGCTGAAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0603488957301621					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19659848	19659898	22079887	22079937	13487	hg38	N/A	enh109800	N/A	Enhatls82547	enhancer	GATA6e+7-9				GACAAGCAGAGGTAATCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27435986263643192					GATA6	chr18	22169588	22202528	87355				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612542	19612592	22032581	22032631	13488	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-1				GAGGCGGGTAGGCGTGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018450263589599461					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612644	19612694	22032683	22032733	13489	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-10				TCTTGGTAGATGAAATAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41675038309123252					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612596	19612646	22032635	22032685	13490	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-11				TTGAAGGAAGCACAGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72883887877599385					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612579	19612629	22032618	22032668	13491	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-12				CTTCAAAATCTGACTCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21022944939485211					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612697	19612747	22032736	22032786	13492	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-13				GAAAATAGAGTTAATGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.676835613769506					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612339	19612389	22032378	22032428	13493	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-14				AGAAAACTGAAACTCGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73367272608257306					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612669	19612719	22032708	22032758	13494	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-15				AATCTCCAAGAAAAGCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28297086839498209					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612627	19612677	22032666	22032716	13495	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-16				AAAAAGAGAAAAAGCATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.960289154967696					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612478	19612528	22032517	22032567	13496	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-2				ATCACTACCTATGGTGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87979375033308671					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612759	19612809	22032798	22032848	13497	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-3				ACTGGGGGCCGTAAGTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2666352540107759					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612771	19612821	22032810	22032860	13498	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-4				CGGCCCCCAGTGAATATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.232817030319892					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612523	19612573	22032562	22032612	13499	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-5				GTAAGTAGGGGAGTGATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8618269815737429					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612369	19612419	22032408	22032458	13500	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-6				CAAACAGTCATAACAGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.365497129391769					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612511	19612561	22032550	22032600	13501	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-7				CCTTCAAGGAATGTAAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6249237972919008					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612497	19612547	22032536	22032586	13502	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-8				TTGGAGTGAGTGAGCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3411653509461321					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19612724	19612774	22032763	22032813	13503	hg38	N/A	enh32493	N/A	Enhatls82547	enhancer	GATA6e+8-9				CTTCAAAGTGTTGCAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44911133243022949					GATA6	chr18	22169588	22202528	133055				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607140	19607190	22027179	22027229	13504	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-1				CTGGTACACGGACGATGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6771905343513627					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607194	19607244	22027233	22027283	13505	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-10				CTGCCCTCGACAGAGGTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2840803474547693					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606407	19606457	22026446	22026496	13506	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-11				CGCGCACCCACAGGGACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.2851255728889539					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606864	19606914	22026903	22026953	13507	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-12				TCCTCTTAGGAGCTACAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.094551365180414					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606484	19606534	22026523	22026573	13508	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-13				CGCGGCCTTCAAGCAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1639593310925171					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607239	19607289	22027278	22027328	13509	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-14				CTAGATTTTACCTGACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.375999881176754					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606439	19606489	22026478	22026528	13510	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-15				CTTCTTCCCCACGTGGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8696755855902376					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606154	19606204	22026193	22026243	13511	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-16				TTTAGTAGACAGAGCCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6530209041905968					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607003	19607053	22027042	22027092	13512	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-17				GCCAGCTCATGCTCTCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2386770988159448					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606583	19606633	22026622	22026672	13513	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-18				TAGTCCAAGGTTTTAACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2409521986231784					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607042	19607092	22027081	22027131	13514	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-19				GTCATTCCACACCTCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1592014659681258					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606704	19606754	22026743	22026793	13515	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-2				AGCGGATGGCGTCACAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.45905050440009					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606225	19606275	22026264	22026314	13516	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-20				ATCCCCCAGCTCCTAGTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9528331959557406					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606548	19606598	22026587	22026637	13517	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-21				AATTAGCACAGCCAAACCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2594365423508638					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607129	19607179	22027168	22027218	13518	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-22				ACGATGCAGGGGCTTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2840978487526167					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606510	19606560	22026549	22026599	13519	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-23				GGCAATCCACATGTGCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7969167056978828					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606877	19606927	22026916	22026966	13520	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-24				CGGCCGCTGCTTTTCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.65314006082779					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607224	19607274	22027263	22027313	13521	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-25				GGAAAGAGCATGTTGCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0205467659803684					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606390	19606440	22026429	22026479	13522	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-26				AGGAGGCTAAGGCCATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.24879840969742					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607104	19607154	22027143	22027193	13523	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-27				ACATGATCTTCCAGACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.115671023009754					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606254	19606304	22026293	22026343	13524	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-28				CACTGATTGACTGCTTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5379880328938764					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606797	19606847	22026836	22026886	13525	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-29				TCTGTTATGTCTAAGACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.79500113326875					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606139	19606189	22026178	22026228	13526	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-3				TCCTTGGGTAGGTTACCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.09090492747363					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606181	19606231	22026220	22026270	13527	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-30				TCACAAGTTAGTTATTTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4259534475278279					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606828	19606878	22026867	22026917	13528	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-31				TGATACTGCAGCTGTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2304572961438049					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606679	19606729	22026718	22026768	13529	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-32				GTGTGGAAAGCGGCAGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6445791859896719					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606727	19606777	22026766	22026816	13530	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-33				TTAATGAAAAGAGGGGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7662011418403782					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606356	19606406	22026395	22026445	13531	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-34				TGTCTGGGCTGAGGCACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9253860338421269					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606116	19606166	22026155	22026205	13532	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-35				CTATTCCAGTAGCTTCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0706377089669079					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606966	19607016	22027005	22027055	13533	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-36				CAAGGGTCTGTTTCCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2261124747569969					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606537	19606587	22026576	22026626	13534	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-37				AGCAGCATTTTCCCAAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.47651959265538					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606949	19606999	22026988	22027038	13535	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-38				CAGACTGTGAGTGTCTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2260210572383592					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606933	19606983	22026972	22027022	13536	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-39				CAGTCTGCCTGCCCAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6694363085294244					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606495	19606545	22026534	22026584	13537	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-4				TTGAAGGCCGCGGCTCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0159860734276043					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606450	19606500	22026489	22026539	13538	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-40				CGTGGATGCAGGCCTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9468528288550164					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606371	19606421	22026410	22026460	13539	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-41				CAGGGCCAGCCTGGTTGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0016839975502911					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607078	19607128	22027117	22027167	13540	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-42				TGGCCAGGCTTCCCAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8491290846639812					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606128	19606178	22026167	22026217	13541	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-43				CTTCTTCCTGGTCCTTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.03371822776448					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607274	19607324	22027313	22027363	13542	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-44				CTCACTGGATTTCAGTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5050200423474789					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607090	19607140	22027129	22027179	13543	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-45				ACACTCTGGCTTCCTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3126582123080981					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606325	19606375	22026364	22026414	13544	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-46				ATCCAGGTGGCTCAGGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5703151542874512					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606652	19606702	22026691	22026741	13545	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-47				AGGAGTTAATAAGCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1059185516195571					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606596	19606646	22026635	22026685	13546	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-48				TGATTTCATTTTCTAGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43158405442395409					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606921	19606971	22026960	22027010	13547	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-49				TCTGGCCCCCGTCCCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1499478475672182					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606341	19606391	22026380	22026430	13548	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-5				ACTCCAGGAGGTATTGATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5610667276397958					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607165	19607215	22027204	22027254	13549	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-50				GGAGAAGCAGAGGAATGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.51847175326395					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606843	19606893	22026882	22026932	13550	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-51				GGAGAGAAGCACAGCCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.26389292941812					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606979	19607029	22027018	22027068	13551	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-52				GGCCTGTCTCTCACCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9269743206926258					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606614	19606664	22026653	22026703	13552	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-53				AATCAGGGAGGGGGCATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8995654882367741					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607053	19607103	22027092	22027142	13553	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-54				TCATCCCCTCTCCCCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.043811096455685					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607292	19607342	22027331	22027381	13554	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-55				GTGAGTCTCAATTTCTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5863673489663936					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19607152	19607202	22027191	22027241	13555	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-56				CTGCTTCTCCTCCTGGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7961088590613441					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606096	19606146	22026135	22026185	13556	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-57				TAGACTAAGAGAAAGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.953931700415225					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606627	19606677	22026666	22026716	13557	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-58				GCATGGAAGGGCAGCTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.517484425325903					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606774	19606824	22026813	22026863	13558	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-59				AAAATTAACTAAATTTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606893	19606943	22026932	22026982	13559	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-6				GCGGCCGGTGGAGAGGCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.94079331491993					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606763	19606813	22026802	22026852	13560	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-60				TTAGTTAATTTTATCATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.46110226445666					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606236	19606286	22026275	22026325	13561	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-7				TCTGGATCAAACCCTATACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.456881859528206					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606283	19606333	22026322	22026372	13562	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-8				GAATGAGATTGAATTAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4116434219682352					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-76933	chr18	19606462	19606512	22026501	22026551	13563	hg38	N/A	enh88330	N/A	Enhatls82547	enhancer	GATA6e+9-9				GCTGGACGCTTCCCAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6810077586438812					GATA6	chr18	22169588	22202528	140255				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	951
enhrx-6226	chr1	59170598	59170648	58704926	58704976	13564	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-1				GAAGTTGTGACAGCCATGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6064926033834841					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170652	59170702	58704980	58705030	13565	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-10				TAGCTTGCTTTTATACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4075302204163988					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170280	59170330	58704608	58704658	13566	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-11				TGTTTTGGGTAAAGATCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95633222453245492					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170481	59170531	58704809	58704859	13567	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-12				ACTGAATACACAATTTAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5506872467575861					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170409	59170459	58704737	58704787	13568	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-13				TTACATTAACAATAGGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.088611840848287					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-lit92	chr1	59170243	59170293	58704571	58704621	13569	hg38					enhancer	JUNe-1-14				TCCTTCACAATTTGCGCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13031981826847369													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6226	chr1	59170320	59170370	58704648	58704698	13570	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-15				AGCTATCAATTTACATTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8102937751028364					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170557	59170607	58704885	58704935	13571	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-16				TTAGGTAGATAAGAAACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7217261685093872					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-lit93	chr1	59170256	59170306	58704584	58704634	13572	hg38					enhancer	JUNe-1-17				GCGCACAAGGAAATTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.883736545773641													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6227	chr1	59170711	59170761	58705039	58705089	13573	hg38	N/A	N/A	N/A	Enhatls6777	enhancer	JUNe-1-18				CGCACCCGTGACACAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2228067062092478					MYSM1	chr1	58643439	58700090	4989				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6226
enhrx-6226	chr1	59170669	59170719	58704997	58705047	13574	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-19				AAGCTATACCCCAACCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4070947309380231					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170335	59170385	58704663	58704713	13575	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-2				TGATAGCTCATCTTCATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.700872467631007					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-lit94	chr1	59170695	59170745	58705023	58705073	13576	hg38					enhancer	JUNe-1-20				CATGTTGTCAGGACATCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92092698641848325													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6226	chr1	59170684	59170734	58705012	58705062	13577	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-21				CACCTTGGGCACATGTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.26040291086993					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6227	chr1	59170735	59170785	58705063	58705113	13578	hg38	N/A	N/A	N/A	Enhatls6777	enhancer	JUNe-1-3				AACTTATATTGCTGAGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.12815199817692					MYSM1	chr1	58643439	58700090	4989				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6226
enhrx-6226	chr1	59170508	59170558	58704836	58704886	13579	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-4				GGCTGAGCTAATTTAAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7511237411135441					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170585	59170635	58704913	58704963	13580	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-5				GGAAGACCCCTCCCCCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.499135709503157					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170450	59170500	58704778	58704828	13581	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-6				ATCTGCATTTTTACATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39049353032997958					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170371	59170421	58704699	58704749	13582	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-7				CCTCTGCTCACCTGAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.172115995081233					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170295	59170345	58704623	58704673	13583	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-8				GAAATTCAACAGAACTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.228641719472219					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6226	chr1	59170620	59170670	58704948	58704998	13584	hg38	N/A	N/A	fant1747	N/A	enhancer	JUNe-1-9				GACATCAATCAATATGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59244956610284227					MYSM1	chr1	58643439	58700090	4546				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6225
enhrx-6195	chr1	58498793	58498843	58033121	58033171	13585	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-1				GGGATACAATATGGGTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2020304414145192					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498951	58499001	58033279	58033329	13586	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-10				CTCAAGAAGCCCCTCACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075539956674353981					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498774	58498824	58033102	58033152	13587	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-11				TCCCATTCAGAACAGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1012878472571809					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499086	58499136	58033414	58033464	13588	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-12				TTTCCAAAGATGAGGGCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2339223951744718					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499128	58499178	58033456	58033506	13589	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-13				GGAAACAGCACATTCAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19899367824169209					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499075	58499125	58033403	58033453	13590	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-14				GAGGGCATAAGGAAACCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10462173130848949					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498810	58498860	58033138	58033188	13591	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-15				ATCTGGAGAGCAGAGGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48364240196924269					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498840	58498890	58033168	58033218	13592	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-16				TCAGGGGATTAAAGAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23133503079888579					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499149	58499199	58033477	58033527	13593	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-2				GTTTTAGTCATATTCCCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13833260017116661					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499060	58499110	58033388	58033438	13594	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-3				TACAACTTCACGGTTCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1107737931402536					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498966	58499016	58033294	58033344	13595	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-4				ACTACAGGACTCTCACTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17595682551596939					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498929	58498979	58033257	58033307	13596	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-5				GACAGAAGGATCTTCTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64437100042929352					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499016	58499066	58033344	58033394	13597	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-6				CAGGCTGGTATCAGATAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54391709172845326					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498895	58498945	58033223	58033273	13598	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-7				CTTGTGCAAACTTTGTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1617884124888167					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58499031	58499081	58033359	58033409	13599	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-8				TTATCTGATAGCAGCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28011586089698692					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58498822	58498872	58033150	58033200	13600	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-10-9				GCTCTCCAGATGGATTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1014110837422624					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497157	58497207	58031485	58031535	13601	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-1				CGTTTAACCGGAGAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0088182928029827967					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497415	58497465	58031743	58031793	13602	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-10				GCTTTGATCAAAGCTCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.785382932329694					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497083	58497133	58031411	58031461	13603	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-11				CAGTAATAGGTAAAACGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27797959668717692					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497145	58497195	58031473	58031523	13604	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-12				AACAGGCATGAACGTTTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085580537264432766					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497430	58497480	58031758	58031808	13605	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-13				CATAATGGGATATATCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21554687261428021					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497958	58498008	58032286	58032336	13606	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-14				TACTCACCTTCATAATCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2340346503795343					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497193	58497243	58031521	58031571	13607	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-15				AGTTTCTTCCATCGCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092294422773250284					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497070	58497120	58031398	58031448	13608	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-16				GAAGATGTTTGGGCAGTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.067865468611717675					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497266	58497316	58031594	58031644	13609	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-17				TACACAAATGCTTAAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21041535031800751					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497917	58497967	58032245	58032295	13610	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-18				TCCATAATTAGGATTTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70388061219458964					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497764	58497814	58032092	58032142	13611	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-19				GTATCTGCATCATCTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.952856449851379					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497543	58497593	58031871	58031921	13612	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-2				ACACCGTGCACTTGAGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059601054914463207					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497474	58497524	58031802	58031852	13613	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-20				AGCCCAAACTGAGCTGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18635835615524271					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497523	58497573	58031851	58031901	13614	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-21				TGGCTGAATAGCAGTTACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6114600374941187					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497941	58497991	58032269	58032319	13615	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-22				TGAGTAAGAAGACATGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24838211384082251					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497019	58497069	58031347	58031397	13616	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-23				ACTGTGGAAAGTCTTTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2220703523329389					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497318	58497368	58031646	58031696	13617	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-24				GCAATTCAGCTTCCTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12924283956341759					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497306	58497356	58031634	58031684	13618	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-25				GTATCCCTTCTCCCTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092795653169956013					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497579	58497629	58031907	58031957	13619	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-26				AATTTCAACCTTAGGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52091715467433286					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497620	58497670	58031948	58031998	13620	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-27				GCTGTGATAAAATGGAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14474116279806379					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497223	58497273	58031551	58031601	13621	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-28				CAAAGGAAATCTGGCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02681757414202323					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497207	58497257	58031535	58031585	13622	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-29				GCTGAGGGCTGAAGCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55368170450912513					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497240	58497290	58031568	58031618	13623	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-3				GTTGGTCCTTAGCATCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41361377673828109					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497445	58497495	58031773	58031823	13624	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-30				GATATTGTTTTTCTGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2098223008570656					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497128	58497178	58031456	58031506	13625	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-31				AATAAGAATCTTCAGTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54415338578007966					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497003	58497053	58031331	58031381	13626	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-32				CAGTAGATGAAGCAGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33213749528353909					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497397	58497447	58031725	58031775	13627	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-33				AAAGCAAACCTTTCCCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.194109993370912					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497059	58497109	58031387	58031437	13628	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-34				GAAATCTTTAAGAAGATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3349324978672138					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497568	58497618	58031896	58031946	13629	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-35				TAGGAAATGAGGGTATAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.92552288641755					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497294	58497344	58031622	58031672	13630	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-36				AGAAGGGATACAGGGGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26293050778730293					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497095	58497145	58031423	58031473	13631	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-37				AAACGGATGGGAAAAAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0048048682188477779					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497869	58497919	58032197	58032247	13632	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-38				CATATGCACATTATAATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.78466609570626					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497721	58497771	58032049	58032099	13633	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-39				TTTGAGAAGCAGAGTTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21993155965001851					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497805	58497855	58032133	58032183	13634	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-4				CACTAGCACTAGGGTCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085126794027616678					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497282	58497332	58031610	58031660	13635	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-40				GGGGCTGGTGGCTGAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.144521335056542					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497981	58498031	58032309	58032359	13636	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-41				CACAGTGTATGGCACATAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13372435086774309					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497837	58497887	58032165	58032215	13637	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-42				CTGCATTTTAACAAGACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1088169291292876					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497734	58497784	58032062	58032112	13638	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-43				GCTTCTCAAAGTGTGGTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5405262850286785					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497384	58497434	58031712	58031762	13639	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-5				CATGTGCCCTAAGCCTCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29481217432049289					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497855	58497905	58032183	58032233	13640	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-6				GTGCATATGCATTGCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38917171111223481					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497906	58497956	58032234	58032284	13641	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-7				TGACCTTAGCATCCATAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1799054148362963					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497486	58497536	58031814	58031864	13642	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-8				GCTGAGGAAGGTTTAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.171839912701177					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58497970	58498020	58032298	58032348	13643	hg38	N/A	enh49789	N/A	Enhatls6747	enhancer	JUNe-11-9				TAATCCTCAGGCACAGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53828168261365128					OMA1	chr1	58467926	58546802	430106				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472326	58472376	58006654	58006704	13644	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-1				GGCTGATGATAGGTCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14220451032914211					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472670	58472720	58006998	58007048	13645	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-10				CATTCTACATCTCAGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0387683590073642					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472390	58472440	58006718	58006768	13646	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-11				GGTCAGAGTATCCTTCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.483526712087978					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472426	58472476	58006754	58006804	13647	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-12				AGAGGAGGTGCTTGCGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1178495495377918					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472485	58472535	58006813	58006863	13648	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-13				GAAACATGTGGATTCTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0083508285104579236					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472537	58472587	58006865	58006915	13649	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-14				TATGCAAATGCTACACAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0870465967849319					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472574	58472624	58006902	58006952	13650	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-15				AAAGCAGAATGGCATCATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.600791474319274					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472363	58472413	58006691	58006741	13651	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-16				GAATTCACTGGGCAGGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35832498355795372					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472633	58472683	58006961	58007011	13652	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-17				ATAATAAACTAACATCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23964584467839731					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472291	58472341	58006619	58006669	13653	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-18				TGACTCAGAGCCAGAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11366988275219531					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472585	58472635	58006913	58006963	13654	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-19				AGCTGGAAGACAAAGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048806923975316739					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472337	58472387	58006665	58006715	13655	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-2				CTATCATCAGCCTACAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1122235336495					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472441	58472491	58006769	58006819	13656	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-20				AGGGACGGGAGGCAGAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6053247856760846					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472452	58472502	58006780	58006830	13657	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-3				GAGCATTCCTGAGGGACGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52091487312723361					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472310	58472360	58006638	58006688	13658	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-4				AAGGAACTGGTGTAAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59418174153728054					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472609	58472659	58006937	58006987	13659	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-5				GCATCTCAGAATGAGTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.357324156829942					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472412	58472462	58006740	58006790	13660	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-6				CGAGAGAGGGAATCATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26755169477842611					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472551	58472601	58006879	58006929	13661	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-7				ACAAATTGGAGTCTTAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23315107586771941					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472473	58472523	58006801	58006851	13662	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-8				TCCTGTGAAGGTGAAACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68556027535840824					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58472374	58472424	58006702	58006752	13663	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-12-9				TTGCAGGTTCAGAATTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40964423909934711					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468803	58468853	58003131	58003181	13664	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-1				GTAACTGCCCTTCCCTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31889092421423437					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469096	58469146	58003424	58003474	13665	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-10				TGGCTAACTGAAGAATTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3347079361266565					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469044	58469094	58003372	58003422	13666	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-11				AAATTTTAAGTAGTGTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74101279328912562					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469002	58469052	58003330	58003380	13667	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-12				CTGACATGTTTTAAAATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26177437258729869					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469057	58469107	58003385	58003435	13668	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-13				CTTAAAATTTGCATTGTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.229278589649608					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468905	58468955	58003233	58003283	13669	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-14				CTCAATAGCCTGAAAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15318887186313321					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468978	58469028	58003306	58003356	13670	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-15				AAAGAGAAGCCATCAAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.101168188328849					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468845	58468895	58003173	58003223	13671	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-2				AAATCACACGTGACAATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51278531800565319					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468869	58468919	58003197	58003247	13672	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-3				TCCTACTATGCCCTGGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.559780667597172					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469017	58469067	58003345	58003395	13673	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-4				ATAGATGGCCCTCAATTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34585302713947552					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468858	58468908	58003186	58003236	13674	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-5				CAATGGATGGCCCAGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33361789035100159					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468939	58468989	58003267	58003317	13675	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-6				TCTTTGTCATTGAAGCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.553655147985541					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58469108	58469158	58003436	58003486	13676	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-7				TCAGTTAGCCAAAGTGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1892191143578186					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468814	58468864	58003142	58003192	13677	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-8				TCCCTCAATGGGTAAATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.369734735872544					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58468964	58469014	58003292	58003342	13678	hg38	N/A	enh380	N/A	Enhatls6747	enhancer	JUNe-13-9				AAAATCGGGTTTCTTCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37522439125884188					OMA1	chr1	58467926	58546802	459057				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6190	chr1	58066331	58066381	57600659	57600709	13679	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-1				AATTCTATAGGCGCTAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33228732909531822					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066295	58066345	57600623	57600673	13680	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-10				TCAGTGACTGGGATTTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2441194478200473					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066135	58066185	57600463	57600513	13681	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-11				CAACCAGCTACCAGGTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45904619485011239					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066267	58066317	57600595	57600645	13682	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-12				GGCCTCTTTGAACCACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22864641024513219					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066010	58066060	57600338	57600388	13683	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-13				TAAAAAATCTCACCACTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03572531857830704					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066343	58066393	57600671	57600721	13684	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-14				TTATGCTAATTCAATTCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39914369463043642					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066101	58066151	57600429	57600479	13685	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-15				AGTCCTGCTTTGTTCTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87205087266064518					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066447	58066497	57600775	57600825	13686	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-16				GAAAAATGAGATGGGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.026772920556123039					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066391	58066441	57600719	57600769	13687	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-17				TTTGCAATAATTACATCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15746194678453951					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066425	58066475	57600753	57600803	13688	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-18				TTTCAAAAGTTGAGCTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1619996393410219					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066279	58066329	57600607	57600657	13689	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-19				AGAAAGGGGCTTCCTCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.151983304694267					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066152	58066202	57600480	57600530	13690	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-2				GCTATGGTACCCTTGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059830084595284487					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066239	58066289	57600567	57600617	13691	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-3				TTAACCCATCCCGACCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4313476806320831					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066048	58066098	57600376	57600426	13692	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-4				GGCTTGTCCCATTGTTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1054169230938795					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066168	58066218	57600496	57600546	13693	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-5				CCATAGCCAATGCTGCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0072576362233194884					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066222	58066272	57600550	57600600	13694	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-6				TGCAAAATGCTTAGAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10030170976110191					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066027	58066077	57600355	57600405	13695	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-7				CCAGGGCGAGCAAGACAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078452826589118951					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066202	58066252	57600530	57600580	13696	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-8				GCATTGACAAGGCTGGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17312949118240939					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58066306	58066356	57600634	57600684	13697	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-14-9				GGCACTGGCTTTCAGTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81429822128691043					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062820	58062870	57597148	57597198	13698	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-1				AGATAAGTGGCGTTAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94746280886654455					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58063017	58063067	57597345	57597395	13699	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-10				GGACAGCAAGAGTCAACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033530760307578518					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062717	58062767	57597045	57597095	13700	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-11				GATGTGAATTTCAAAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1739888048623433					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58063105	58063155	57597433	57597483	13701	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-12				GTTTGATACAACAGTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.312638100304545					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062772	58062822	57597100	57597150	13702	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-13				GTTCTTTAATTCCAGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.030716961265632382					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062921	58062971	57597249	57597299	13703	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-14				TGTATGGCTTCTTGATTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46409651777688438					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58063033	58063083	57597361	57597411	13704	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-15				TAGGAAGGGAATTTTTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044941800906704042					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062807	58062857	57597135	57597185	13705	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-16				TAGGCTGAGGCTGGCAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77740022525565244					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062849	58062899	57597177	57597227	13706	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-17				CCTGGATTTACATATCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38636386625079988					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062790	58062840	57597118	57597168	13707	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-18				CAAAGGTAGGAAGAAATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17670087914383839					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58063064	58063114	57597392	57597442	13708	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-19				GCACTGGGAAGAAACGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4337075578761741					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062831	58062881	57597159	57597209	13709	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-2				CGCCACTTATCTTATCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11556761530832239					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062996	58063046	57597324	57597374	13710	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-20				AGGAGTCAGAGCTGTGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27054044235474167					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58063052	58063102	57597380	57597430	13711	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-21				CTTCCCAGTGCTACACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33709814799136151					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062641	58062691	57596969	57597019	13712	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-22				ACTCTCTGGGATGAGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.774678381178871					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062628	58062678	57596956	57597006	13713	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-23				CTGGCTTCTATGAACTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.078708747977698931					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062968	58063018	57597296	57597346	13714	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-24				GAAATCTCTTGCAGAAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67217095811306593					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062957	58063007	57597285	57597335	13715	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-25				GCAAGAGATTTCAGAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61714661719986319					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062679	58062729	57597007	57597057	13716	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-3				TCAGATGGGCTAATTTATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16998754428713231					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062872	58062922	57597200	57597250	13717	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-4				CAATCAGGCAGGCTTTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50207259780661606					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062937	58062987	57597265	57597315	13718	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-5				GGGCATGTTGATTTGCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26718699844131172					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062753	58062803	57597081	57597131	13719	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-6				GAACTGTCTGAGCTGAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33458461381174631					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062883	58062933	57597211	57597261	13720	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-7				GGTGGATGTGACAATCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1121001233139607					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062905	58062955	57597233	57597283	13721	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-8				TAGATGGCAGATTTGTAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63300798628898713					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58062693	58062743	57597021	57597071	13722	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-15-9				ATAAACACTCACTTTCAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.051264830288907409					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057520	58057570	57591848	57591898	13723	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-1				ACTCCGCTACACCTACTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12566173467954619					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057751	58057801	57592079	57592129	13724	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-10				AAAGCCTGGGGCTAGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36881759479915682					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057905	58057955	57592233	57592283	13725	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-11				GTCTTCTGGGAAGCCATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.194785948124465					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057891	58057941	57592219	57592269	13726	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-12				CTGCCTTAGGCTATGTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41320128461819478					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057825	58057875	57592153	57592203	13727	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-13				CATTTCCAGATGTTCCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22001775900526069					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057811	58057861	57592139	57592189	13728	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-14				ATAAGGGAAGATTTCCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82463213559520654					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057773	58057823	57592101	57592151	13729	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-15				GCCAGGCTCTTCCTGAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37021660783019777					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057878	58057928	57592206	57592256	13730	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-16				TCATTTTTCAAGGCTGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078824370612124744					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057562	58057612	57591890	57591940	13731	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-17				TATTAGTTTTCTTCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59076178483591169					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057844	58057894	57592172	57592222	13732	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-18				AATGGAAAAGAAGGACTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47486926743515773					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057795	58057845	57592123	57592173	13733	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-19				GCACTTAAGGAGGCAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.084402006805229024					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057594	58057644	57591922	57591972	13734	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-2				ATCTAATACCTTCTTGCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059431462713116542					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057784	58057834	57592112	57592162	13735	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-3				CTCCTTAAGTGCCAACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20517299493365429					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057694	58057744	57592022	57592072	13736	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-4				TTCTGCAATCTAATAGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00394388426304184					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057674	58057724	57592002	57592052	13737	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-5				GAAATCCTTTCAAGGCAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16772566671699621					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057738	58057788	57592066	57592116	13738	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-6				ATCCCTTTAGCAGAAAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32680240987551529					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057619	58057669	57591947	57591997	13739	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-7				ACAGAGTGTATTTGTAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3041843686673435					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057549	58057599	57591877	57591927	13740	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-8				TTCTTTAGAGAATCCTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.100360248315009					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58057918	58057968	57592246	57592296	13741	hg38	N/A	enh42970	N/A	Enhatls6740	enhancer	JUNe-16-9				ATGATTCTTTTGCCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39795310580285731					DAB1	chr1	56994777	57424060	164994				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019563	58019613	57553891	57553941	13742	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-1				GTTTAGGGGAGGTTAACGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70602743147432734					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019764	58019814	57554092	57554142	13743	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-10				AAGCGAGGAGATATTTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89077446605359989					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019576	58019626	57553904	57553954	13744	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-11				TAACGGGAGGGGGCAATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.375457447202322					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019836	58019886	57554164	57554214	13745	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-12				ACAAGAGGTATTTTCCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25118565019737732					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019777	58019827	57554105	57554155	13746	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-13				TTTGATAAGGTAATCTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88915448005376485					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019428	58019478	57553756	57553806	13747	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-14				GGTCAAATGCAGCAGCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0049620313158011244					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019822	58019872	57554150	57554200	13748	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-15				GAGCAGGAAGGCCTCCAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.942562035700508					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019635	58019685	57553963	57554013	13749	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-16				GCATATCTGCCTCCTTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61320731691746933					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019666	58019716	57553994	57554044	13750	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-17				GTTGTATCTGCTGCGTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13322583897293719					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019686	58019736	57554014	57554064	13751	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-18				AGGATGAGAGAGACCTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45857084437754331					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019395	58019445	57553723	57553773	13752	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-19				GCCTAGAGAGTTGAAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55178236836435812					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019370	58019420	57553698	57553748	13753	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-2				ATCGCTCCTATTGACAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.471882841479528					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019441	58019491	57553769	57553819	13754	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-20				AGCAACAAGGTGAGGACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25058238991108212					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019594	58019644	57553922	57553972	13755	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-21				TTAGGAATCTCAGCTGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80615461815962075					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019749	58019799	57554077	57554127	13756	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-22				ATTAAAGAAAACATGAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2615191886229199					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019454	58019504	57553782	57553832	13757	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-23				GGACTGCAGGGCGCTCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078050049647930941					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019501	58019551	57553829	57553879	13758	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-24				ATCCTGGCCAGAGCTGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093612091223480215					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019731	58019781	57554059	57554109	13759	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-25				TTAATTCCTTCCTTCTCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26965593803585558					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019532	58019582	57553860	57553910	13760	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-26				GAGGTGGAAACCAGATGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0352351509488394					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019406	58019456	57553734	57553784	13761	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-27				TGAAAAAGCAGGGAGGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.065403803934087					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019793	58019843	57554121	57554171	13762	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-28				CCTAAGGAGACAACAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20118287194280579					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019623	58019673	57553951	57554001	13763	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-29				GGAGAGAGAACACCAGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2591325496706921					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019485	58019535	57553813	57553863	13764	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-3				AGGGTGCTCATTGGCAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31266981518757819					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019806	58019856	57554134	57554184	13765	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-30				CAGAAGAAGGGATAGAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068620584673510746					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019321	58019371	57553649	57553699	13766	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-31				AGAGAAAGGATCCTGCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1427978116875375					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019310	58019360	57553638	57553688	13767	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-32				TCTAGCCTGGACCACAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4193808255522643					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019335	58019385	57553663	57553713	13768	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-33				ATTTTTTCTATTTAAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.8903958923031392					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019346	58019396	57553674	57553724	13769	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-34				AATAGAAAAAATAAAAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.591855580975982					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019717	58019767	57554045	57554095	13770	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-4				CTCTACCGGTTATTTCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038590650069700187					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019702	58019752	57554030	57554080	13771	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-5				AAGCAGGCTTATCAACCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5337664113577153					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019465	58019515	57553793	57553843	13772	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-6				CGCTCACTGAGGCTGGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.281778902811841					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019549	58019599	57553877	57553927	13773	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-7				ACAAGGTGTGAAGTGTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093811498661633727					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019851	58019901	57554179	57554229	13774	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-8				TTCTAGTAGCCTAGAACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5701559854784416					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	58019513	58019563	57553841	57553891	13775	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-17-9				GCTGGTTCAGGTATTCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5337129483800841					DAB1	chr1	56994777	57424060	117504				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996633	57996683	57530961	57531011	13776	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-1				AGTGACTGATTTGACAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30592234264534					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996935	57996985	57531263	57531313	13777	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-10				GGTCACAAGGTGTTCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.282673062297862					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996982	57997032	57531310	57531360	13778	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-11				TGGAAAATTACAATCAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016081905651978					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996920	57996970	57531248	57531298	13779	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-12				AGTGAGGGAGCTTCTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15579572820263179					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996783	57996833	57531111	57531161	13780	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-13				TTCACTTGCTTCAGGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47403230297528542					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996902	57996952	57531230	57531280	13781	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-14				CCTTGTGAAATTCCTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0754492962775291					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996807	57996857	57531135	57531185	13782	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-15				AATCACAAAAGAAGTGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91937570882120223					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996857	57996907	57531185	57531235	13783	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-17				GCAGGAACAAATCACAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.1886945806732512					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996704	57996754	57531032	57531082	13784	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-2				ACACTGGTACTTGATTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44546356722886749					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996662	57996712	57530990	57531040	13785	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-3				TCTCTCATCACCTCACTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63415481496495363					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996686	57996736	57531014	57531064	13786	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-4				TTACTTTTGATTTAAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.666409107312552					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996734	57996784	57531062	57531112	13787	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-5				GTGATGGCTTAGCTTGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039072381453348279					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996720	57996770	57531048	57531098	13788	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-6				TGGGCTCGGAGGCTTGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39684883467414028					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996957	57997007	57531285	57531335	13789	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-7				TTTCTCTTGCAGGCAGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75274895226911					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996759	57996809	57531087	57531137	13790	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-8				TGTAGTCATGCAGGTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4856419776621088					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996881	57996931	57531209	57531259	13791	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18-9				GGTTAATTGCTCAGTTAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.414159353154647					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57996840	57996890	57531168	57531218	13792	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-18/NANOGe-18/GATA6e-13/SMAD4e-11				TGGTGGAATGTCATCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.0978655335797409					DAB1	chr1	56994777	57424060	105520				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906103	57906153	57440431	57440481	13793	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-1				GATGGGAACTTCTTACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18001817873875781					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905879	57905929	57440207	57440257	13794	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-10				TCTTGATCCCTGCCATGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2116387303683237					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905891	57905941	57440219	57440269	13795	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-11				GTGAAAATGGCTCCAACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21557030083489451					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906069	57906119	57440397	57440447	13796	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-12				TGCTCCTTATATGCCTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038830555616771692					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905868	57905918	57440196	57440246	13797	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-13				CAGGGATCAAGATTAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25528496729645422					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906143	57906193	57440471	57440521	13798	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-14				CTTTCTTCACAAGCCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37359738021061462					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905904	57905954	57440232	57440282	13799	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-15				GGGATCCAGACATGTGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49478265698947582					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905808	57905858	57440136	57440186	13800	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-16				AGAGAAGGTTTCATTCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32467081205083848					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905853	57905903	57440181	57440231	13801	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-17				GAAGTAGGTAAAATACAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.518517197049039					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905769	57905819	57440097	57440147	13802	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-18				GAATTTCAAAAAATGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0612164183805309					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905823	57905873	57440151	57440201	13803	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-19				GAAGAAAGAATGGTCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13483493997988469					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906003	57906053	57440331	57440381	13804	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-2				CTGCCACTGCACTAATGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19296721661685859					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906086	57906136	57440414	57440464	13805	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-3				GGAGCACCTTTCGAAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35323289526642487					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906035	57906085	57440363	57440413	13806	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-4				AGGTGGAATTAGGACCACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2134779770663342					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906130	57906180	57440458	57440508	13807	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-5				CCCAGACAGTAATCCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02980448288062466					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906052	57906102	57440380	57440430	13808	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-6				TGATGGATGACTGTTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0765593504056925					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57906021	57906071	57440349	57440399	13809	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-7				TCAGGGTGATTCAGCCAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.028993674701924078					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905927	57905977	57440255	57440305	13810	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-8				CTAAGAGATTACAATCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1245091052511598					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57905790	57905840	57440118	57440168	13811	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-19-9				TCTTCTCAACCTGCAAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057604982270020658					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6208	chr1	59050455	59050505	58584783	58584833	13812	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-1				CGATGTGTGATGCCCTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0087321486848179215					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050534	59050584	58584862	58584912	13813	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-10				AGGTGGTGAGAGGTCTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0517202503550817					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050583	59050633	58584911	58584961	13814	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-11				TGGATCAGGACTGTCCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41666970302849371					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050519	59050569	58584847	58584897	13815	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-12				CACCACCTGCCCTTATCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31091207512869912					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050654	59050704	58584982	58585032	13816	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-13				CCAGTCTCCCACCCAAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41465534350956929					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050427	59050477	58584755	58584805	13817	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-14				GGTGCTTCCTTTCCCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47038526279420573					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050375	59050425	58584703	58584753	13818	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-15				GTGGCTGCCTCAGGAATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61205933653886424					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050283	59050333	58584611	58584661	13819	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-16				AAAGTCACTGAGTGTTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36201155538479679					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050296	59050346	58584624	58584674	13820	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-17				CAGTGACTTTTAATTTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1160702574125589					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050505	59050555	58584833	58584883	13821	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-18				ATCTCAAGGACAGCTGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042053481692070689					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050342	59050392	58584670	58584720	13822	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-19				GGCAACAAATAAAGAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.919773340092607					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050394	59050444	58584722	58584772	13823	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-2				AGTGTGGGGTTCGAGCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42291689352528972					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050409	59050459	58584737	58584787	13824	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-3				GCACCGTGACTCATCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98269455823201135					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050440	59050490	58584768	58584818	13825	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-4				ACACATCGCCGGGCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2167842754243525					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050615	59050665	58584943	58584993	13826	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-5				GACCCCTTTTGATAACTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1230344693751572					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050603	59050653	58584931	58584981	13827	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-6				TAACTCTAAGGAGCCTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14927970471835389					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050467	59050517	58584795	58584845	13828	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-7				ACCTCCACATCCCCTTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1938270508104423					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050569	59050619	58584897	58584947	13829	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-8				GACAAATTCGTCTGCCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00052211799650753469					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6208	chr1	59050321	59050371	58584649	58584699	13830	hg38	N/A	enh11914	fant1744	Enhatls6759	enhancer	JUNe-2-9				CAACAGCTTCCAGACAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2516205439046551					TACSTD2	chr1	58575432	58577252	7315				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6207
enhrx-6190	chr1	57877338	57877388	57411666	57411716	13831	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-1				TAATGAGAGGGTGATCGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95548258560212529					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877338	57877388	57411666	57411716	13832	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-1				TAATGAGAGGGTGATCGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95548258560212529					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877231	57877281	57411559	57411609	13833	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-10				AGGAGGGTACAGTTCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54319606408975041					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877351	57877401	57411679	57411729	13834	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-11				TAGGGAATGGAGCTAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21452508741458851					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877351	57877401	57411679	57411729	13835	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-11				TAGGGAATGGAGCTAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21452508741458851					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877021	57877071	57411349	57411399	13836	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-12				ACTTTCAAATGAGGAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13015345887370611					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877304	57877354	57411632	57411682	13837	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-13				TCACTTTGTTCAAGAGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52058915822028529					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877073	57877123	57411401	57411451	13838	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-14				CAGTTCTAGCTTGACTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.028382083077223081					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877101	57877151	57411429	57411479	13839	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-15				CCAGCCAAAATTTGCCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1622481152978161					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877062	57877112	57411390	57411440	13840	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-16				TGACTTTTCAGGCATATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19885804633809051					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877287	57877337	57411615	57411665	13841	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-17				GAGATGTCTTTCAAAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35901097354509631					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877273	57877323	57411601	57411651	13842	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-18				AGACATCTCTGGGTTTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61285846087502138					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877170	57877220	57411498	57411548	13843	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-19				GCAGCCAGACTCTGGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1006099752142819					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877320	57877370	57411648	57411698	13844	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-2				AAAGTGACTAGCGGCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67969126595387208					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877320	57877370	57411648	57411698	13845	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-2				AAAGTGACTAGCGGCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67969126595387208					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877216	57877266	57411544	57411594	13846	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-20				TCTTCTGGTTAGACACCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31266914798384648					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877187	57877237	57411515	57411565	13847	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-21				AATAACAGGTGCTGGGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1889645831588484					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877257	57877307	57411585	57411635	13848	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-22				CAGATCCCTTCTCTCTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.173133205761953					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877364	57877414	57411692	57411742	13849	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-23				TGGGGATGCGGAGTAGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.058359980633948247					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877377	57877427	57411705	57411755	13850	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-3				CGCATCCCCACTGGCCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.046077901363299867					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877127	57877177	57411455	57411505	13851	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-4				TCGGATAGACCACAGTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1629298617016737					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877115	57877165	57411443	57411493	13852	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-5				CAGTTATTTGGCTGCCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036921644879404393					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877154	57877204	57411482	57411532	13853	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-6				TGGCTGCTGACACACTACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15813990562677341					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877391	57877441	57411719	57411769	13854	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-7				AGGACATCTTTTGTCCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64002091411685469					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877200	57877250	57411528	57411578	13855	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-20-8				ACCTGTTATTCACACTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53291366157452091					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57877414	57877464	57411742	57411792	13856	hg38	N/A	enh66937	fant1716	Enhatls6740	enhancer	JUNe-20-9				TTTAAGCCCTCTGCACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15835608750452521					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874844	57874894	57409172	57409222	13857	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-1				GTGGTATGATAGACCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39603795971045791					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874910	57874960	57409238	57409288	13858	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-10				AGACAGAGATTAGCAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41586509954759932					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874814	57874864	57409142	57409192	13859	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-11				AAAGGTTCCACCTGCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2227510171608921					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874984	57875034	57409312	57409362	13860	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-12				TAATAGGAAGAACTTAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-7.3287970697243541					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874782	57874832	57409110	57409160	13861	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-13				GCCACATGGGGAAAAAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72059965323838282					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874968	57875018	57409296	57409346	13862	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-14				ATACAGGAAAGCAGTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.508585886497642					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874830	57874880	57409158	57409208	13863	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-15				TCCTGGGGGCTGCACCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82095556049179419					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874876	57874926	57409204	57409254	13864	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-2				AGATAGTGTTACTGATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.157066127600067					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57875000	57875050	57409328	57409378	13865	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-3				GAGATCCATACCAGCTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21691232585385539					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874743	57874793	57409071	57409121	13866	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-4				GCATAGAAGAGTCTGCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.089891764323450446					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874795	57874845	57409123	57409173	13867	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-5				CTTTGGAGGACAAGCCACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54725777956868871					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874863	57874913	57409191	57409241	13868	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-6				AACACTATCTGCTACCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0204839155946454					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57874764	57874814	57409092	57409142	13869	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-7				GCTTCCGGCAGCCCAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23900913397931839					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57875020	57875070	57409348	57409398	13870	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-8				CTCCTGGCTGTCACAGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00456909665351848					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57875068	57875118	57409396	57409446	13871	hg38	N/A	enh66937	N/A	Enhatls6740	enhancer	JUNe-21-9				TGTCTGAAGTCATGGTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44318942258162319					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847816	57847866	57382144	57382194	13872	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-1				CAGCACACGGTAAATCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.004800674256502521					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847592	57847642	57381920	57381970	13873	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-10				TGGACTTCTGAGCCAAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32118575277507111					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847556	57847606	57381884	57381934	13874	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-11				TCAGGTCACCCCAGGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058185231579090578					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847788	57847838	57382116	57382166	13875	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-12				TGAGAGACTCACCTTATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13257624005312341					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847859	57847909	57382187	57382237	13876	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-13				GCTGTTGGGTGAGAGTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28246498847799778					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847689	57847739	57382017	57382067	13877	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-14				ATAAGCATAAGCAAATGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94288850158654691					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847829	57847879	57382157	57382207	13878	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-15				TTGATCTTCCCAACAGCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20045102325777589					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847612	57847662	57381940	57381990	13879	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-16				CCAGATGCTGAAGACAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15005463708623931					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847771	57847821	57382099	57382149	13880	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-2				CTCTCAACTGAGACGGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.800358113588538					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847574	57847624	57381902	57381952	13881	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-3				TTGGGAAGCTCATCAGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095710329181634246					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847542	57847592	57381870	57381920	13882	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-4				GACCAGGGGCTATCTCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0505736265751339					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847930	57847980	57382258	57382308	13883	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-5				CAGTCTGTGACTAGCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.032730367455754777					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847799	57847849	57382127	57382177	13884	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-6				CACTGGTTCATCCTCAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020321476336544748					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847726	57847776	57382054	57382104	13885	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-7				ATTAAGTCTCTAAATTGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49520925667898391					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847647	57847697	57381975	57382025	13886	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-8				GATCACAACAAAGAAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036727878323210679					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57847873	57847923	57382201	57382251	13887	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-22-9				ATGTCTCCTCCCTTGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018285041991997559					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802577	57802627	57336905	57336955	13888	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-1				CGGCAGGATTGGAACTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56098029565203489					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802836	57802886	57337164	57337214	13889	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-10				GTTACAGTAGTCCATGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22247216089586361					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802633	57802683	57336961	57337011	13890	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-11				TACCTAGAGGAGCTGATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75077131070334713					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802486	57802536	57336814	57336864	13891	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-12				ATGGGAAAGTGACATCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20715592943708491					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802802	57802852	57337130	57337180	13892	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-13				TGCAGGAGGCTTTAGCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14586411307735239					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802701	57802751	57337029	57337079	13893	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-14				CTTCAACTGTTCAGTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29010731973580561					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802606	57802656	57336934	57336984	13894	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-15				GAGAGGCAATACTGTGTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066714276275056481					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802778	57802828	57337106	57337156	13895	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-16				TGATGAGAGGTTTGGATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1057625181994873					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802718	57802768	57337046	57337096	13896	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-17				GGTGCCAGACACTGAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95735229357128515					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802819	57802869	57337147	57337197	13897	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-18				GAAAGGGGATGGTGGCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29545766653756511					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802444	57802494	57336772	57336822	13898	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-19				ATAACAAATACAGATTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96527403108335275					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802563	57802613	57336891	57336941	13899	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-2				ATCCTGCCGTGTCACATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46262107691403459					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802513	57802563	57336841	57336891	13900	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-20				CAGATAAGGAAATAGACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74593166148434753					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802897	57802947	57337225	57337275	13901	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-21				CTATTTTGAAAATAAATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3954397848997191					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802499	57802549	57336827	57336877	13902	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-22				ACTTTCCCATTTTACAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020322551076041421					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802646	57802696	57336974	57337024	13903	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-3				TGTTTGTGAGTACTACCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044206304407051068					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802883	57802933	57337211	57337261	13904	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-4				AATTTTAGGAAAGTTCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39269636505245759					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802423	57802473	57336751	57336801	13905	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-5				GGACAATTACTGTAATCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73891786208295673					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802533	57802583	57336861	57336911	13906	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-6				AGGCTAAATGAGTCTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.269943548613655					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802739	57802789	57337067	57337117	13907	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-7				CTATTGATATTCAAATGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62834655578789889					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802682	57802732	57337010	57337060	13908	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-8				GAAGAATCAGTGTCACTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040998866689167447					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57802791	57802841	57337119	57337169	13909	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-23-9				TTAGCTGTGTGGTTGATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02391797237002373					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773029	57773079	57307357	57307407	13910	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-1				TAGATTATCAGCCCTAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39297966021149511					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773333	57773383	57307661	57307711	13911	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-10				GTGGTCTGGATTCAACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39105018005214193					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773429	57773479	57307757	57307807	13912	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-11				GTGGCCTAAATTCAACAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15568090779145849					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773538	57773588	57307866	57307916	13913	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-12				GTGATCTAGATTCCATAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1377369714921953					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773129	57773179	57307457	57307507	13914	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-13				AGGTGTGGTCTCACCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49044649941588242					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773268	57773318	57307596	57307646	13915	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-14				GTGGTCCAGATTCAACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066353671271805775					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773461	57773511	57307789	57307839	13916	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-15				ATGGTCTATATTCAACATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.593952455061165					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773061	57773111	57307389	57307439	13917	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-16				CTGCTCTTTCACTATCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32424479929971439					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773585	57773635	57307913	57307963	13918	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-17				TGTAGTCTAGATTCAGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1482697787856562					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773236	57773286	57307564	57307614	13919	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-18				GTGGCCTAGATTCAACAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41556159634752338					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773608	57773658	57307936	57307986	13920	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-19				GATTCAACAGATTGGACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41901784863444608					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773041	57773091	57307369	57307419	13921	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-2				AGGGTGGCAGTACCTGTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1533625359008832					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773553	57773603	57307881	57307931	13922	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-20				TAGATCACACCTCCCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38796957618292921					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773313	57773363	57307641	57307691	13923	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-21				AGGCAAAGAAGGTGTGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64005820328476026					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773520	57773570	57307848	57307898	13924	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-22				CTAGGGAAAGAAGGTGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29514508463731859					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773287	57773337	57307615	57307665	13925	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-23				AGCAGACAGGAAACGGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.82712414974964					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773566	57773616	57307894	57307944	13926	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-24				ATGGAGAAGGAGACCTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15712781427336761					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773108	57773158	57307436	57307486	13927	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-25				GGAGGAGTGGGGAAGATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085247973227320584					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773448	57773498	57307776	57307826	13928	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-26				AACATACAGGAAAGGGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.90352467853033					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773480	57773530	57307808	57307858	13929	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-27				AATTGACAGGGAAGAGAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39019134793709331					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773185	57773235	57307513	57307563	13930	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-28				ATGGAGAAGGAGGTGTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094234997384631827					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773347	57773397	57307675	57307725	13931	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-29				ACAGGGAAGGGGATGTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059108725750381362					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773493	57773543	57307821	57307871	13932	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-3				GTGGTCTAGATTGAATTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3671609603748584					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773416	57773466	57307744	57307794	13933	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-30				AACAAACAGGAAAGGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.260813903642783					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773144	57773194	57307472	57307522	13934	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-31				AACAGATGGTGAAGGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8614926550876429					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773255	57773305	57307583	57307633	13935	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-32				AACAGACAGGAAAGGGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.171117382136964					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773222	57773272	57307550	57307600	13936	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-33				ACAGAAAGGGAAAGAGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35688379884856081					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773158	57773208	57307486	57307536	13937	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-4				TGCGGTCTAGATTCAACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48002082477122288					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773365	57773415	57307693	57307743	13938	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-5				GTAGTCTAGATTCAACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49944749432431451					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773078	57773128	57307406	57307456	13939	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-6				GAGCAGGACCTCTTGCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48303812732420759					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773300	57773350	57307628	57307678	13940	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-7				GTGGCCTAGGTTCAGCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99289863523419508					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773198	57773248	57307526	57307576	13941	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-8				CTAGACTCAGCGGATGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093306844247323689					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6190	chr1	57773389	57773439	57307717	57307767	13942	hg38	N/A	N/A	N/A	Enhatls6740	enhancer	JUNe-24-9				GATTCAACAGATACGAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56594063073511713					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6189
enhrx-6189	chr1	57728518	57728568	57262845	57262895	13943	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-1				ACTTAGTACCCTTAGGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47545004864789181					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728129	57728179	57262456	57262506	13944	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-10				TGTATCTTCATGGGTGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0689356166134409					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728415	57728465	57262742	57262792	13945	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-11				CCTCTTCTGCTGAGTACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0991820495293252					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728594	57728644	57262921	57262971	13946	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-12				CTCATGGAATACTTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.053586239254320163					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728361	57728411	57262688	57262738	13947	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-13				ATGGGTTCCATACCTTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34657950551542632					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728536	57728586	57262863	57262913	13948	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-14				TAAGTGAAAACCCACCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4938121176845176					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728349	57728399	57262676	57262726	13949	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-15				GTGTGATGCTTCCCTTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.032481348434427848					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728547	57728597	57262874	57262924	13950	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-16				GTTCTGAGATACCTGAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031482819569514008					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728185	57728235	57262512	57262562	13951	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-17				CTGCAGCCCAGCCACCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20192468828787871					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728459	57728509	57262786	57262836	13952	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-18				ACCTTCTCTCAGAATCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010836746816865779					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728168	57728218	57262495	57262545	13953	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-19				CTGCAGGTAAGGACAAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1911778113265645					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728276	57728326	57262603	57262653	13954	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-2				TATCACCCGGAGTTCTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4101896280448597					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728558	57728608	57262885	57262935	13955	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-20				GTATCTCAGAACACAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1255719586662363					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728576	57728626	57262903	57262953	13956	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-21				CCTGGCTGGTGTTGTCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55771825715576206					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728237	57728287	57262564	57262614	13957	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-22				GTAAGTAAAATCACTGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34399964002989					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728379	57728429	57262706	57262756	13958	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-23				TTGATCACATTTCACTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0262642511591163					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728115	57728165	57262442	57262492	13959	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-24				TGGCTCTGGGGGAAGCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33266392261218908					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728263	57728313	57262590	57262640	13960	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-3				TACTTTCCGCTCTTATCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14912182818799641					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728327	57728377	57262654	57262704	13961	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-4				TTTGCATCCAGACTGATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37323360975581521					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728199	57728249	57262526	57262576	13962	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-5				TTGCAATGCCACATCCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053491913180815677					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728606	57728656	57262933	57262983	13963	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-6				TATTCCATGAGCACAACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.79730034062105					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728498	57728548	57262825	57262875	13964	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-7				GGGGCCCATATTTTCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02947985470241336					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728627	57728677	57262954	57263004	13965	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-8				GGCAAACATTAAGGGTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22887801601888211					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6189	chr1	57728652	57728702	57262979	57263029	13966	hg38	N/A	enh49784	N/A	Enhatls6739	enhancer	JUNe-25-9				TAAGGGGCTATCTTCCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86057623608353329					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6188
enhrx-6187	chr1	57554619	57554669	57088946	57088996	13967	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-1				ACCGGAACGGTGAAGCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75527979481142193					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554321	57554371	57088648	57088698	13968	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-10				GTGAGAGCTTGAGTAGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092909672002910337					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554390	57554440	57088717	57088767	13969	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-11				CTACATTCCGATTTGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01800152780907532					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554370	57554420	57088697	57088747	13970	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-12				AGGTGACTGGGCTGTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18138551323568031					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554562	57554612	57088889	57088939	13971	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-13				AATTAGTAAAAGAATGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6131602678831209					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554355	57554405	57088682	57088732	13972	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-14				TTCAAGGGAGAATGAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35053879135783222					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554638	57554688	57088965	57089015	13973	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-15				ATGGTTAAGGGCACAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.525708911754084					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554527	57554577	57088854	57088904	13974	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-2				GGGCCTGCATCTCAAGCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00486781987568448					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554655	57554705	57088982	57089032	13975	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-3				GCGTTTGACCTCTGGCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81522332467470038					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554547	57554597	57088874	57088924	13976	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-4				GTGTAAGGCACTTAAAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65501928087297334					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554606	57554656	57088933	57088983	13977	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-5				GTCTGGCTAGAGGACCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11768835134635559					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554688	57554738	57089015	57089065	13978	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-6				CTCACAAGCAATGTACACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.011864996883075849					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554489	57554539	57088816	57088866	13979	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-7				GTTTATCTTTGACACCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92229354346780079					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554503	57554553	57088830	57088880	13980	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-8				GGAGATGATTATCGCCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76894207863218489					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6187	chr1	57554581	57554631	57088908	57088958	13981	hg38	N/A	N/A	N/A	Enhatls6737	enhancer	JUNe-26-9				AATTGTCACCCTGGCATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14328900464869779					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6186
enhrx-6185	chr1	57533193	57533243	57067520	57067570	13982	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-1				TGGTGAGCCAACTCTGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62277126069274147					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533055	57533105	57067382	57067432	13983	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-10				GCTCTACCTATTGCTAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5911401365967538					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532731	57532781	57067058	57067108	13984	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-11				AGCTCTTGGGCCTGAAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051865948366689139					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533213	57533263	57067540	57067590	13985	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-12				TGCGTGTGCACATGCGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.099727467966451988					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533137	57533187	57067464	57067514	13986	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-13				ATAATGATTCAAGCCACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30336367230161237					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532745	57532795	57067072	57067122	13987	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-14				CTTAATAAGAGATAAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-8.45866765725776					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533246	57533296	57067573	57067623	13988	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-15				ATAAGACTCAGAAATGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62376535855647752					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532880	57532930	57067207	57067257	13989	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-16				GGACAGATGGGAAGATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34840652250839871					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532851	57532901	57067178	57067228	13990	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-17				AACAGGAAGCTACCATTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59301178476095029					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533094	57533144	57067421	57067471	13991	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-18				AAGTGAGGCTCACAGTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40897072577257532					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532683	57532733	57067010	57067060	13992	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-19				GGCGCCTCATTTTTTTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076605161191605					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533043	57533093	57067370	57067420	13993	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-2				ATAGGTAGAGCCCCCACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18446511501027951					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533019	57533069	57067346	57067396	13994	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-20				CTTTATTTACAGAGGTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0922298887852784					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532962	57533012	57067289	57067339	13995	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-21				AATTGTGAAACTCAGAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18156484681867011					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532927	57532977	57067254	57067304	13996	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-22				TTTTTAGATAGTGACTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77263235873114466					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533032	57533082	57067359	57067409	13997	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-23				GGTCAGAGGGACCTGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094008152119040581					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532839	57532889	57067166	57067216	13998	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-24				AAAATACTCATTCCCTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84575226399165992					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533298	57533348	57067625	57067675	13999	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-25				CTAAAAAAATCAAAGTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37742274338535009					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532988	57533038	57067315	57067365	14000	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-26				TCTGAGCTGAGAGCAGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38822200284461328					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532796	57532846	57067123	57067173	14001	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-27				CAGGAGAAGAGAATGACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43824349426982739					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532779	57532829	57067106	57067156	14002	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-28				CTCCTGCTCTGCCAGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29617091605115231					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533081	57533131	57067408	57067458	14003	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-29				AGTGATAAGGTAACTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46646374636906779					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532716	57532766	57067043	57067093	14004	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-3				AGATAAGGCTGGGCTTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69260157657005239					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533150	57533200	57067477	57067527	14005	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-30				TCTCTCACAACAACCCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6435069825723102					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533109	57533159	57067436	57067486	14006	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-31				CCTCACTTTCCTTATCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.209227688843507					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532824	57532874	57067151	57067201	14007	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-32				AGTATTTTATCTCCTTCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7217261685093872					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533004	57533054	57067331	57067381	14008	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-33				AAATAAAGAAATAAATCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7632739813215359					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533272	57533322	57067599	57067649	14009	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-4				AGCAGGTTAGCTTGTTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.21607834015142					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57533314	57533364	57067641	57067691	14010	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-5				TGCAATTACCACTTTACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13785486414000661					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532868	57532918	57067195	57067245	14011	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-6				CCTGTTAATGATGGACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.266754523807357					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532704	57532754	57067031	57067081	14012	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-7				GCTTTTAAGGGGCTGCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03316918919730337					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532812	57532862	57067139	57067189	14013	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-8				CCAAAGGCCTTTCCAATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064169107372662612					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-6185	chr1	57532768	57532818	57067095	57067145	14014	hg38	N/A	enh49781	N/A	Enhatls6735	enhancer	JUNe-27-9				TAAATTGAGCCCCAGCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01405331314892487					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6184
enhrx-lit95	chr1	57476358	57476408	57010685	57010735	14015	hg38					enhancer	JUNe-28-1				GGCCGGTAGCTAGATAGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.563253728806495													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6178	chr1	57476307	57476357	57010634	57010684	14016	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-10				AGCAGATAGCTTAAGGGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53927977135194527					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-lit96	chr1	57476395	57476445	57010722	57010772	14017	hg38					enhancer	JUNe-28-11				ATCACCACTGGGCTCCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35441434509670422													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6178	chr1	57476296	57476346	57010623	57010673	14018	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-12				AAGCTATCTGCTTTCCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42028739543766419					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-6179	chr1	57476509	57476559	57010836	57010886	14019	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-13				CATTGAAAATATAAGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.428727231774398					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-6178	chr1	57476282	57476332	57010609	57010659	14020	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-14				GAAGTGAAGAACAACCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38116943865931369					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-6178	chr1	57476318	57476368	57010645	57010695	14021	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-15				TAAGGGTAAAGGAGATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55803950794265433					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-6179	chr1	57476527	57476577	57010854	57010904	14022	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-2				TGCTGCATGAAAGTATATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11150544360059431					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-lit97	chr1	57476375	57476425	57010702	57010752	14023	hg38					enhancer	JUNe-28-3				GATAATATAAGTCCACAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1180368626203326													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6179	chr1	57476411	57476461	57010738	57010788	14024	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-4				GATCCATTTGGTGAGCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64032110875320736					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-6179	chr1	57476448	57476498	57010775	57010825	14025	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-5				GTTCTAGCCTGATGGATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.528288975925085					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-6179	chr1	57476549	57476599	57010876	57010926	14026	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-6				ACAATCAGTTATTGTAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081493229366782882					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-6179	chr1	57476423	57476473	57010750	57010800	14027	hg38	N/A	N/A	N/A	Enhatls6729	enhancer	JUNe-28-7				TCATCCAACAGTGATCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23355444723694341					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6178
enhrx-6178	chr1	57476226	57476276	57010553	57010603	14028	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-8				TCAGCAATACAGCTCAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034660993578620472					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-6178	chr1	57476254	57476304	57010581	57010631	14029	hg38	N/A	N/A	N/A	Enhatls6728	enhancer	JUNe-28-9				TGGTGCAAACATTGAGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67101839040382538					DAB1	chr1	56994777	57424060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6177
enhrx-6174	chr1	57424314	57424364	56958641	56958691	14030	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-1				GCCGCAGACGTTCCCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46967733931573108					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424329	57424379	56958656	56958706	14031	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-10				TCTGCGGCAGACTCTGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28655450535400462					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424387	57424437	56958714	56958764	14032	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-11				CTTCATCTGCACCATAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048786392195410137					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424628	57424678	56958955	56959005	14033	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-12				TGTTCTCAGAAGTAGGATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15499300947018571					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424445	57424495	56958772	56958822	14034	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-13				TCAGCAATAAAACCTACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47990536528814648					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424535	57424585	56958862	56958912	14035	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-14				CTTAGACTCTAAAGAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39588067032984248					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424216	57424266	56958543	56958593	14036	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-15				CTGCACCACTTACACACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26731027374367572					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424479	57424529	56958806	56958856	14037	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-16				ATCAATGGAGAGAGCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23324996717679281					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424491	57424541	56958818	56958868	14038	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-17				TCTCCATTGATCCAATTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94113999150523076					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424363	57424413	56958690	56958740	14039	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-18				AGACTCAGCATGAGTCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.98809465493759885					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424406	57424456	56958733	56958783	14040	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-19				GAAGCAATTATCCAGATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.125559563999025					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424502	57424552	56958829	56958879	14041	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-2				AGGACAATCACCCAGTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70044397279573289					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424281	57424331	56958608	56958658	14042	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-20				TGTCTGCAGGGTCACTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.947719093935771					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424522	57424572	56958849	56958899	14043	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-21				GAGGCTGTGGAAGTAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69368831025053113					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424596	57424646	56958923	56958973	14044	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-22				AGCAACCATTCTCTTTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13179088023782379					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424345	57424395	56958672	56958722	14045	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-23				AGAGAGGAGCTCTGGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31663829587449521					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424246	57424296	56958573	56958623	14046	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-3				ATCACCCAATCTGACTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21133939961848761					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424465	57424515	56958792	56958842	14047	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-4				GGGAACTGAATGATCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48364804018912921					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424376	57424426	56958703	56958753	14048	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-5				TGCTGAGTCTTCCTAGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61416309451639628					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424551	57424601	56958878	56958928	14049	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-6				GTCTAAGCCCATGGCTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17019642284981309					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424293	57424343	56958620	56958670	14050	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-7				GGTTATCATCCCTGTCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.061316241994922					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424577	57424627	56958904	56958954	14051	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-8				TGCTATTTCCCCAGATCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33487396048470158					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6174	chr1	57424417	57424467	56958744	56958794	14052	hg38	N/A	N/A	N/A	Enhatls6724	enhancer	JUNe-29-9				TCAGCATTGATCCAATTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40012170199235741					C8B	chr1	56929206	56974383	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6173
enhrx-6199	chr1	58920175	58920225	58454503	58454553	14053	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-1				AAGCTTTGTCGACGGATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0075507142307373806					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920283	58920333	58454611	58454661	14054	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-10				CTGATGCTACTTAGAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25186624782559819					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920226	58920276	58454554	58454604	14055	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-11				TCTGTGAAGGGCACTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32159851734183242					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920226	58920276	58454554	58454604	14056	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-11				TCTGTGAAGGGCACTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32159851734183242					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920319	58920369	58454647	58454697	14057	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-12				AGGGAGGGTCCCCAGGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.947557561354316					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920416	58920466	58454744	58454794	14058	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-13				TTGTTTTGTCTGTGAACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1741573051479933					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920198	58920248	58454526	58454576	14059	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-14				GCAGGCTAGGGGCGGGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54291848213597749					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920198	58920248	58454526	58454576	14060	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-14				GCAGGCTAGGGGCGGGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54291848213597749					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920379	58920429	58454707	58454757	14061	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-15				CAGAAAGGCCTAGAGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2274138315939791					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920159	58920209	58454487	58454537	14062	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-16				AAAGCTTTTCTGTGTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088258428581123927					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920331	58920381	58454659	58454709	14063	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-17				GGACCCTCCCTCCTCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.98602606605609833					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920394	58920444	58454722	58454772	14064	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-18				GAACTGATGAAATCTCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30075787130886111					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920308	58920358	58454636	58454686	14065	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-19				TCCTCCTGCTCCCCACCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.327496933377996					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920261	58920311	58454589	58454639	14066	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-2				GAGGTGTGGCCCTCGGACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.526328477974782					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920104	58920154	58454432	58454482	14067	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-3				GGTCGACTCCTGCAAGCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057663920531183639					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920186	58920236	58454514	58454564	14068	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-4				ACGGATGTCAGGGCAGGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01153306846522884					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920348	58920398	58454676	58454726	14069	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-5				GCCGCCTCTCAATCAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16581249756561611					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920126	58920176	58454454	58454504	14070	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-6				CTCAAGGTGAACTCTGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44096400731651447					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920142	58920192	58454470	58454520	14071	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-7				CTGTGGCCGTCTCTTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28846162570891087					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920443	58920493	58454771	58454821	14072	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-8				TTACTGTCACAAACTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15358474923835971					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920214	58920264	58454542	58454592	14073	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-3-9				TGCAGGGGCGTGTCTGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28401422451871489					OMA1	chr1	58467926	58546802	13354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58920214	58920264	58454542	58454592	14074	hg38	N/A	enh26735	N/A	Enhatls6750	enhancer	JUNe-3-9				TGCAGGGGCGTGTCTGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28401422451871489					OMA1	chr1	58467926	58546802	9204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6154	chr1	57277168	57277218	56811495	56811545	14075	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-1				TGGGTTGTTGACAAACTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.0482203158932					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277213	57277263	56811540	56811590	14076	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-10				TCATGGTCCACCTGGAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26724966334639261					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277069	57277119	56811396	56811446	14077	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-11				AAGCACATAATTAGATAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00538328975223307					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277045	57277095	56811372	56811422	14078	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-12				AGTGCAAGGGAGTGTCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066450877391646					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277155	57277205	56811482	56811532	14079	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-13				AACTGCCTGGAGGTAATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20320555023812059					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277141	57277191	56811468	56811518	14080	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-14				AATCTCTGGAATTTCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48007438528559782					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57276953	57277003	56811280	56811330	14081	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-15				CATTTTGAAGCTAAATTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1995903449096339					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277188	57277238	56811515	56811565	14082	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-16				GGCATCATCTCAACAATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34106117594753921					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57276992	57277042	56811319	56811369	14083	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-17				TTCAAGGCTGAAAGCAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2417393306013477					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277008	57277058	56811335	56811385	14084	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-18				AAGTTTTAAAGTGTGTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7920902893243451					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277272	57277322	56811599	56811649	14085	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-19				AGCAAGTACCACAGACTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.269877357698578					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277317	57277367	56811644	56811694	14086	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-2				TTGCCACTCATGCCTGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083326409615018318					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277086	57277136	56811413	56811463	14087	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-20				GTGCTTACTTAGAAATTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016782115875246181					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277103	57277153	56811430	56811480	14088	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-21				TTTGTTTCAAGATTAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1038119380301703					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277343	57277393	56811670	56811720	14089	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-3				TCAAGACCTCTGGGTGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38035424262865269					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277114	57277164	56811441	56811491	14090	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-4				TCTTGAAACAAACCAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2003890568676441					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277241	57277291	56811568	56811618	14091	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-5				GACAGTCACTGGAACAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20596509246732139					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277305	57277355	56811632	56811682	14092	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-6				AGAAATGTATTGCCTTACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53672059432553443					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277230	57277280	56811557	56811607	14093	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-7				CCATGACTCAAGACAGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25549131086702909					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277126	57277176	56811453	56811503	14094	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-8				ACAGCTGGGTCGCCATGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.041557968746611822					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6154	chr1	57277058	57277108	56811385	56811435	14095	hg38	N/A	enh49776	N/A	Enhatls6702	enhancer	JUNe-30-9				TAGATAAGCTGGCAGTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.392476446372921					FYB2	chr1	56718788	56819404	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6153
enhrx-6199	chr1	58913916	58913966	58448244	58448294	14096	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-1				GATCAAGATTAACCCACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.212867609123669					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913805	58913855	58448133	58448183	14097	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-10				GTATGTTTGCTGGGAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41224782624536149					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913874	58913924	58448202	58448252	14098	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-11				AGCAGTTGTTGGCAAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0097655276162965134					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913836	58913886	58448164	58448214	14099	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-12				TGTTGAAATTCTGGCCAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.8986662210361546E-06					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58914041	58914091	58448369	58448419	14100	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-13				GATAACAGAAATTTTGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56726418389941824					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913889	58913939	58448217	58448267	14101	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-14				AATAAAGGAATTACTTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8252409095380939					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913981	58914031	58448309	58448359	14102	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-15				TATAAACATAGGGTTTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6767648544998091					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913754	58913804	58448082	58448132	14103	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-16				AGTATGTGTTTCTTTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45953947817929891					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913970	58914020	58448298	58448348	14104	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-17				CTTGATATCTATATAAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.168062152588939					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913770	58913820	58448098	58448148	14105	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-18				GCAAAAGAAAAAGGAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54947767555914762					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58914149	58914199	58448477	58448527	14106	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-19				TAAAGAGAAAAGCACAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36022086028497191					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913822	58913872	58448150	58448200	14107	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-2				ACATACCCCTCATGCCTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087480210541893949					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58914002	58914052	58448330	58448380	14108	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-20				GGTAGATAGATAGATAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.56976206514535					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913715	58913765	58448043	58448093	14109	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-3				TTGTTATCTTATGTGATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25680854313449908					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913697	58913747	58448025	58448075	14110	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-4				TGCAATGGCTAACACAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41673757540694262					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58914108	58914158	58448436	58448486	14111	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-5				TGCCTCACACAATTTTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10171989538770861					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913928	58913978	58448256	58448306	14112	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-6				AGGAGGTTGAAGCCCCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.135141810757571					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58914057	58914107	58448385	58448435	14113	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-7				CTTATTGTAAAATTGACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18493604537358621					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913951	58914001	58448279	58448329	14114	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-8				CAAGTAATCACAAACTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4236826129108451					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58913863	58913913	58448191	58448241	14115	hg38	N/A	enh102904	N/A	Enhatls6750	enhancer	JUNe-4-9				CACATACTTAAAGCAGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99415926646115949					OMA1	chr1	58467926	58546802	17744				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898570	58898620	58432898	58432948	14116	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-1				CCCTTCACGTGACGACATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12566071139667531					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898409	58898459	58432737	58432787	14117	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-10				CAGGAAAACACTCCTATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0845758568729873					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898492	58898542	58432820	58432870	14118	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-11				CAGAGGAGCCTACATGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45645038686574668					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898705	58898755	58433033	58433083	14119	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-12				GCTCCCATGTGTGGATAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2187707521264172					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898810	58898860	58433138	58433188	14120	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-13				GAGAAGCCCTACAGTCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74246847545032313					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898687	58898737	58433015	58433065	14121	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-14				GGAGCACAGGCACTCGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1450534396789962					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898839	58898889	58433167	58433217	14122	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-15				AGGTGGCAGGATTGCACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082936796263582746					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898516	58898566	58432844	58432894	14123	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-16				TTCTTTCAGGGCTCCATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43256650717053252					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898516	58898566	58432844	58432894	14124	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-16				TTCTTTCAGGGCTCCATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43256650717053252					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898468	58898518	58432796	58432846	14125	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-17				AAATCATCCCTCCCCACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050732994979632427					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898749	58898799	58433077	58433127	14126	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-18				AGAGCTTGAGCAGCCAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33455061466682318					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898364	58898414	58432692	58432742	14127	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-19				CATTTGTGCCAGACTCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091065433397238521					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898671	58898721	58432999	58433049	14128	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-2				CCGACTCATACAGTACCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092629567365975843					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898581	58898631	58432909	58432959	14129	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-20				ACGACATCAGGGAAGAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.649953901820318					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898646	58898696	58432974	58433024	14130	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-21				TGCAAAGAGGAATGCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48142475952183278					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898646	58898696	58432974	58433024	14131	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-21				TGCAAAGAGGAATGCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48142475952183278					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898543	58898593	58432871	58432921	14132	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-22				GGGGGGAGGGCTCGCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1171323651141221					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898543	58898593	58432871	58432921	14133	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-22				GGGGGGAGGGCTCGCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1171323651141221					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898762	58898812	58433090	58433140	14134	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-23				GGGGTGTGGGAGGCCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4011977912443629					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898420	58898470	58432748	58432798	14135	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-24				AGTGTTTTCCTGGAGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.515709083147022					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898609	58898659	58432937	58432987	14136	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-25				AGGCAAAGCTGGCAGCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.241806128108528					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898620	58898670	58432948	58432998	14137	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-26				ACAGGATGCTGAGGCAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32056718850056359					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898620	58898670	58432948	58432998	14138	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-26				ACAGGATGCTGAGGCAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32056718850056359					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898594	58898644	58432922	58432972	14139	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-27				AGAGGGCTGGCCCCTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61918408004039216					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898529	58898579	58432857	58432907	14140	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-28				CAGAGCAGGAACTCCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22555773761274039					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898529	58898579	58432857	58432907	14141	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-28				CAGAGCAGGAACTCCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22555773761274039					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898557	58898607	58432885	58432935	14142	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-29				ACGTGAAGGGGGCTGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7531419023512331					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898557	58898607	58432885	58432935	14143	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-29				ACGTGAAGGGGGCTGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7531419023512331					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898659	58898709	58432987	58433037	14144	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-3				GTATGAGTCGGCTTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21759192466455141					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898659	58898709	58432987	58433037	14145	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-3				GTATGAGTCGGCTTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21759192466455141					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898632	58898682	58432960	58433010	14146	hg38	N/A	enh26734	fant1740	Enhatls6750	enhancer	JUNe-5-30				CAGCATCCTGTCTGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43828160009350647					OMA1	chr1	58467926	58546802	34939				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898632	58898682	58432960	58433010	14147	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-30				CAGCATCCTGTCTGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43828160009350647					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898775	58898825	58433103	58433153	14148	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-4				GAACGAAATAGGGGGGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49138140813862152					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898822	58898872	58433150	58433200	14149	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-5				TAGGGCTTCTCTCATGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47054395867909682					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898786	58898836	58433114	58433164	14150	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-6				GCCCTGGGTGAGAACGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65978317576467027					OMA1	chr1	58467926	58546802	33361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898504	58898554	58432832	58432882	14151	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-7				CATGAACTGGGCTTCTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036706728997693033					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898480	58898530	58432808	58432858	14152	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-8				AGGCTCCTCTGTCCATGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060514695572304378					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58898397	58898447	58432725	58432775	14153	hg38	N/A	enh26734	N/A	Enhatls6750	enhancer	JUNe-5-9				TGACACTTTGCCCCAATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1741456292162257					OMA1	chr1	58467926	58546802	35039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861145	58861195	58395473	58395523	14154	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-1				CCATATGTGGACGCTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28276794879759531					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861254	58861304	58395582	58395632	14155	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-10				GCCTTTTTCCTCCCTGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.046441226630287123					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861202	58861252	58395530	58395580	14156	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-11				AGGAAGTGAGTCACACAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18696857782545079					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861335	58861385	58395663	58395713	14157	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-12				TCTTTTTTTTGGGAAGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41627276839853222					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861363	58861413	58395691	58395741	14158	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-13				AGAAGACAGCCAGGCAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074572845618468539					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861164	58861214	58395492	58395542	14159	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-14				CTGGTTTGGCTATATCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.468058488308733					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861222	58861272	58395550	58395600	14160	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-15				GTTATGAGGATGAAAGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66780277816865363					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861276	58861326	58395604	58395654	14161	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-16				CAGAAAAGGGAAGACAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32830270025430741					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861035	58861085	58395363	58395413	14162	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-17				TGCAAGTCACTCCCTTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0072485012275874264					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861069	58861119	58395397	58395447	14163	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-18				TTCTTCTCCCATTTTACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2061505544447961					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861046	58861096	58395374	58395424	14164	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-2				GCAATCCGTGCCCAGAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1626376741021798					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861236	58861286	58395564	58395614	14165	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-3				TGTGGCCCTCTGAGGTTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12815366384917071					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861132	58861182	58395460	58395510	14166	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-4				ACTTTCTATGATACCATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62800900822480121					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861375	58861425	58395703	58395753	14167	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-5				GGCAGTACAGGTCTAGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45042571702196238					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861309	58861359	58395637	58395687	14168	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-6				CAAAGATCTAGAGTCTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44562439346066279					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861324	58861374	58395652	58395702	14169	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-7				TAGCCTGGAGCTCTTTTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02839724087789847					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861431	58861481	58395759	58395809	14170	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-8				AGTGTGTGTGGCAACACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0956122677209358					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58861179	58861229	58395507	58395557	14171	hg38	N/A	enh385	N/A	Enhatls6750	enhancer	JUNe-6-9				AATTCAGAACACTGGCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41194006334821059					OMA1	chr1	58467926	58546802	70697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844713	58844763	58379041	58379091	14172	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-1				CGCATGGTGCGCGCACCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0111934882175744					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844665	58844715	58378993	58379043	14173	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-13				CCCCTTGCGCTTCCCAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17633418991128791					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844185	58844235	58378513	58378563	14174	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-2				CACTTGAGGAGGCAGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15213507497476639					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844145	58844195	58378473	58378523	14175	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-27				CCTCCCAGTTAGGCTGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14453643304689009					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844577	58844627	58378905	58378955	14176	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-3				GGAAAAGCGCAATATTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27157242478611932					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844556	58844606	58378884	58378934	14177	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-32				GCGCCGTTTTTTAAGCCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50176137619989158					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844394	58844444	58378722	58378772	14178	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-33				GCTTAGGTAAACAAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42098355549028382					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844699	58844749	58379027	58379077	14179	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-4				CACCATGCGCGAGCCGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22313834583349129					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844615	58844665	58378943	58378993	14180	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7-7				AAAGGGGTGACGGACGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40116677720527871					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844380	58844430	58378708	58378758	14181	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/EOMESe+13				AGCAGCCGGGAAGCTCGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7932290143418621					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844409	58844459	58378737	58378787	14182	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				ACCTAAGCAAGCCTGGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.778470461984315					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844530	58844580	58378858	58378908	14183	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				ACGAGACTATATCCCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58596419712653747					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844266	58844316	58378594	58378644	14184	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				AGGGACACTTAAGTCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0007353989678109					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844171	58844221	58378499	58378549	14185	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				AGGGGTCAGGGACCCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1060904824031319					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844116	58844166	58378444	58378494	14186	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				AGGTGTCAGTGTGCCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.731496503277409					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844158	58844208	58378486	58378536	14187	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				CTGCTCGGGGGTCAGGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88937699031904915					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844677	58844727	58379005	58379055	14188	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				GGCGAGGCATTGCCTCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73702304801129093					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844490	58844540	58378818	58378868	14189	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				TAGCAATCAGCGAGATTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46982963165351371					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844633	58844683	58378961	58379011	14190	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				TCCCTTTCCGAGTCAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34151623474041831					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844096	58844146	58378424	58378474	14191	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7				TTGGAATACCCTGCCGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30032914705286362					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844131	58844181	58378459	58378509	14192	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5				ACTGGGAGGCACCCCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1425486135435258					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844420	58844470	58378748	58378798	14193	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5				AGGGGCGCCCGCCATTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75884260422644112					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844597	58844647	58378925	58378975	14194	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5				TGGGAGTGACCCGATTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.811633767107876					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844311	58844361	58378639	58378689	14195	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5/+13				CTGTGCCCTGCCCCCAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86094380067672749					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844354	58844404	58378682	58378732	14196	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5/+13				GAGCCCACCACAGCTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25680617035433151					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844336	58844386	58378664	58378714	14197	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/EOMESe+5/+13				GGAGGCCTGCCTGCCTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.1898017152658147					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844461	58844511	58378789	58378839	14198	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/SOX2e-16/EOMESe+5				CAGTCTGAGATCAAACTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51328880120902354					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844211	58844261	58378539	58378589	14199	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/SOX2e-16/EOMESe+5				TCAGATCTCCAGCTGCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42346429996213442					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844239	58844289	58378567	58378617	14200	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/SOX2e-16/EOMESe+5/+13				GACAGCTTTGAAGAGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42108405643741231					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844324	58844374	58378652	58378702	14201	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SMAD2e-7/SOX2e-16/EOMESe+5/+13				GCCTCTGTAGGCTCCACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19367696324708469					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844512	58844562	58378840	58378890	14202	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SOX2e-16				GGCGTAGGACCCTCCGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15469991815469861					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844450	58844500	58378778	58378828	14203	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SOX2e-16/EOMESe+5/+13				CAAACTGCAAGGCGGCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8006914564398988					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58844438	58844488	58378766	58378816	14204	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-7/SOX2e-16/EOMESe+5/+13				CGGCAGCGAGGCTGGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42957780324086248					OMA1	chr1	58467926	58546802	78834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774092	58774142	58308420	58308470	14205	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-1				ACCCTGCCTCAATGGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16436168561923181					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773909	58773959	58308237	58308287	14206	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-10				ATGTGAGGGCATCCCTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40235000548099831					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773923	58773973	58308251	58308301	14207	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-11				GCTTGGATAAAAGGATGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06708459528945801					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774177	58774227	58308505	58308555	14208	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-12				AGCACCTGTCCCTCCCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044688284863557651					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773866	58773916	58308194	58308244	14209	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-13				CACAGTGGCCTTCACATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07581105192184015					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774163	58774213	58308491	58308541	14210	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-14				ACAGGTGCTTCCACTGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51400743745598954					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774030	58774080	58308358	58308408	14211	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-15				GGCTTCCAGGGGATGAGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67318317345204526					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773976	58774026	58308304	58308354	14212	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-16				GAGCAAGCAGCTTCATCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042860554039913491					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774080	58774130	58308408	58308458	14213	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-17				TGAGGCAGGGTTGTGGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2299593163422444					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774104	58774154	58308432	58308482	14214	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-18				TGGATCAGAGGCCTAGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1798049279149187					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773877	58773927	58308205	58308255	14215	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-19				TCACATGTTTGGAGATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040193266978169571					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774115	58774165	58308443	58308493	14216	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-2				AAATTGGGTGTCCTAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057437303042994423					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774050	58774100	58308378	58308428	14217	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-20				GGGGTTGGGGGGAGTGATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62284316357821434					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774143	58774193	58308471	58308521	14218	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-21				AGGAGGAAAGAGGAGAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46487212483288048					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774220	58774270	58308548	58308598	14219	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-3				CTTGAGACTCACATGCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49797004096885139					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774191	58774241	58308519	58308569	14220	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-4				AGGACTTACTTAAGCCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40617592101396938					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774019	58774069	58308347	58308397	14221	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-5				GCAAATATTCTGGCTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29111771336596892					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58774130	58774180	58308458	58308508	14222	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-6				AGAATGTCGGAGAACAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49631428537509731					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773897	58773947	58308225	58308275	14223	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-7				GGGAAGGCCTGACCTCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23800864972097369					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773940	58773990	58308268	58308318	14224	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-8				TGAGAAGGCTTTCAGATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65033162949647327					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6199	chr1	58773955	58774005	58308283	58308333	14225	hg38	N/A	N/A	N/A	Enhatls6750	enhancer	JUNe-8-9				GGAGTAAATATCTAATGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-9.5266866139660973					OMA1	chr1	58467926	58546802	145274				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6198
enhrx-6195	chr1	58588960	58589010	58123288	58123338	14226	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-1				GATAGGGTACCGAAGCCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26871594981905073					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588927	58588977	58123255	58123305	14227	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-10				TTTTGACACATCCTAATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1692728189162106					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58589005	58589055	58123333	58123383	14228	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-11				GACTTAGGAAAATGTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12256570063375841					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588913	58588963	58123241	58123291	14229	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-12				AATCTTTGGGAAACACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1202299859956287					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58589020	58589070	58123348	58123398	14230	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-13				TTCAGATGGAGTAAGGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16375608556118129					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588975	58589025	58123303	58123353	14231	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-14				TGACAGACAATGAGACCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39782147826387931					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588943	58588993	58123271	58123321	14232	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-15				GTCAAAACATTGAGAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11462304948479431					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58589034	58589084	58123362	58123412	14233	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-16				GATTTAAAGATGCTTTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.435622247363494					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588731	58588781	58123059	58123109	14234	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-17				ATTTTTCTGAGATATTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2194867213704616					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588689	58588739	58123017	58123067	14235	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-18				TGCTTCCCTATAAATAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48290655054211212					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588892	58588942	58123220	58123270	14236	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-19				GGGACAGTGGAAAGAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1904592193956397					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588830	58588880	58123158	58123208	14237	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-2				TAATCGCCATGACAGCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.014530644284478349					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588803	58588853	58123131	58123181	14238	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-3				CCCCTGACTGGTGACTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15721904235769649					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588874	58588924	58123202	58123252	14239	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-4				AGAGGAACAGTCCCATCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18972076876719479					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588780	58588830	58123108	58123158	14240	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-5				AATTCACCCCTTCCTAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1813235635952099					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588764	58588814	58123092	58123142	14241	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-6				GTGAATTGTGTAACAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25804983709450408					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588858	58588908	58123186	58123236	14242	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-7				GGGGAGAGAAAAGACTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29821022569488381					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588987	58589037	58123315	58123365	14243	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-8				ATTGTCTGTCAGAGTCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0688710723341247					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-6195	chr1	58588791	58588841	58123119	58123169	14244	hg38	N/A	N/A	N/A	Enhatls6747	enhancer	JUNe-9-9				TCCTAGAGCTGGCCCCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.485941828433142					OMA1	chr1	58467926	58546802	333474				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6194
enhrx-lit98	chr1	59250869	59250919	58785197	58785247	14245	hg38					enhancer	JUNe+1-1				ACGCAGTAGTACTCGGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.030829187933291809													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit99	chr1	59250734	59250784	58785062	58785112	14246	hg38					enhancer	JUNe+1-10				AGCGTGTGCGTGTTGTCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3261246012680721													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit100	chr1	59251207	59251257	58785535	58785585	14247	hg38					enhancer	JUNe+1-11				CAGGGTCGCCTGCAGCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.704278156894143													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit101	chr1	59251057	59251107	58785385	58785435	14248	hg38					enhancer	JUNe+1-12				AATCCCGAAGTCGGGAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.807629622120401													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit102	chr1	59250824	59250874	58785152	58785202	14249	hg38					enhancer	JUNe+1-13				TCCGGGAAAACAAGCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86763311397797394													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit103	chr1	59251264	59251314	58785592	58785642	14250	hg38					enhancer	JUNe+1-14				CTGCGAGGATGGAAACTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1217430517780489													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit104	chr1	59250946	59250996	58785274	58785324	14251	hg38					enhancer	JUNe+1-15				GCGCTTCCTAGAGGCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00096090640238255716													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit105	chr1	59250977	59251027	58785305	58785355	14252	hg38					enhancer	JUNe+1-16				TGTAAGTGGTTCCTTTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81131387739592675													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit106	chr1	59251341	59251391	58785669	58785719	14253	hg38					enhancer	JUNe+1-17				TTTCCTGTGAGAAGCATCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2898382122665171													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit107	chr1	59251289	59251339	58785617	58785667	14254	hg38					enhancer	JUNe+1-18				TATATCCTGGCATCCTATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.048115422553785													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit108	chr1	59251191	59251241	58785519	58785569	14255	hg38					enhancer	JUNe+1-19				GACCCTGTCACACTAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.502881056319934													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit109	chr1	59250806	59250856	58785134	58785184	14256	hg38					enhancer	JUNe+1-2				CATCCGCGCCGAGTTGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.03374956295440161													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit110	chr1	59250988	59251038	58785316	58785366	14257	hg38					enhancer	JUNe+1-20				GAATAAAATAACCGCGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82509657694258165													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit111	chr1	59251099	59251149	58785427	58785477	14258	hg38					enhancer	JUNe+1-21				GATTTGCTTGCTTCACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24990207171939849													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit112	chr1	59251276	59251326	58785604	58785654	14259	hg38					enhancer	JUNe+1-22				CATCCTCGCAGAGCCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0816837618035109													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit113	chr1	59251381	59251431	58785709	58785759	14260	hg38					enhancer	JUNe+1-23				GAAAGATCTGACTTCTAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1446899196519531													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit114	chr1	59251164	59251214	58785492	58785542	14261	hg38					enhancer	JUNe+1-24				GCCGGTGCCGTCCACCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92198606807370176													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit115	chr1	59250909	59250959	58785237	58785287	14262	hg38					enhancer	JUNe+1-25				AAATCTCTGCACTCCCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41817115693550638													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit116	chr1	59251178	59251228	58785506	58785556	14263	hg38					enhancer	JUNe+1-26				TAACTCCTGGCAGCCCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.963438835624959													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit117	chr1	59251147	59251197	58785475	58785525	14264	hg38					enhancer	JUNe+1-27				ACCGGCCCCACCTGCAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2735599006151781													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit118	chr1	59251239	59251289	58785567	58785617	14265	hg38					enhancer	JUNe+1-28				GGGGAGGGAAGCGGGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99563402834533743													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit119	chr1	59251016	59251066	58785344	58785394	14266	hg38					enhancer	JUNe+1-29				CGTCCCTAAGGGGTGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59738326422744437													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit120	chr1	59251028	59251078	58785356	58785406	14267	hg38					enhancer	JUNe+1-3				ACCACACACTTTCGTCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.943915118287305													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit121	chr1	59250718	59250768	58785046	58785096	14268	hg38					enhancer	JUNe+1-30				TCTACTCCCCCTCCCGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2927752741998616													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit122	chr1	59251130	59251180	58785458	58785508	14269	hg38					enhancer	JUNe+1-31				ATGAGGGAAATGAAGCTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4037878232219041													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit123	chr1	59251353	59251403	58785681	58785731	14270	hg38					enhancer	JUNe+1-32				AGCATCGAGGGGAGGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.560972707553697													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit124	chr1	59250881	59250931	58785209	58785259	14271	hg38					enhancer	JUNe+1-4				TCGGAGCCCGGGGTAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14056431690439769													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit125	chr1	59250963	59251013	58785291	58785341	14272	hg38					enhancer	JUNe+1-5				AAGCGCTAGACACATGTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.040096306241689													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit126	chr1	59251303	59251353	58785631	58785681	14273	hg38					enhancer	JUNe+1-6				CAGGATATAAGAGTGCGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.088755929497274													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit127	chr1	59250839	59250889	58785167	58785217	14274	hg38					enhancer	JUNe+1-7				TGCGAGTGTCCGCCGCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96299379608170221													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit128	chr1	59250928	59250978	58785256	58785306	14275	hg38					enhancer	JUNe+1-8				CGGGTGGTGGGCGCATATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5479376782462293													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit129	chr1	59251068	59251118	58785396	58785446	14276	hg38					enhancer	JUNe+1-9				CGGGAATCCTGGTTCTTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35477539116049839													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6228	chr1	59479494	59479544	59013822	59013872	14277	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-1				ATAATAAATCGCGTTCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35668384989161611					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479161	59479211	59013489	59013539	14278	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-10				CAGCGCTGACAGAAACTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2383241670582866					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479354	59479404	59013682	59013732	14279	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-11				CTTTGCAAGGACACTGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20009929967210821					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479098	59479148	59013426	59013476	14280	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-12				TGGAGGAAATTCCCATAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2151702800819095					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479173	59479223	59013501	59013551	14281	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-13				TGTCAGCGCTGAAACTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38602526813956878					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479510	59479560	59013838	59013888	14282	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-14				TTATTATTATGCAGACCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73594400294799378					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479293	59479343	59013621	59013671	14283	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-15				CAAGCCAAATGCTTTTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.015271944336186829					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479138	59479188	59013466	59013516	14284	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-16				AGCTCAGTGAGGCGCGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0208704884804629					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479020	59479070	59013348	59013398	14285	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-17				TTGCCTGTGAAAGGTCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3433308121161911					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479056	59479106	59013384	59013434	14286	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-18				CTAGGGTGGGAAGAGGCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.359408979831445					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479610	59479660	59013938	59013988	14287	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-19				TTCTTCCCTCTGTATAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2013775401966586					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479407	59479457	59013735	59013785	14288	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-2				GCGCAGGTTCACACGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34746026373326683					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479407	59479457	59013735	59013785	14289	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-2				GCGCAGGTTCACACGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34746026373326683					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479325	59479375	59013653	59013703	14290	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-20				TACCCTGCCTGGTTGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.400930417643806					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479072	59479122	59013400	59013450	14291	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-21				CCTAGGGAGCTCCCCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4659603086877944					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479264	59479314	59013592	59013642	14292	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-22				GATTTCTAAATCAAGTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1701125297620689					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479525	59479575	59013853	59013903	14293	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-23				AAAGTTGGAGAAAAGCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48609687314911221					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479591	59479641	59013919	59013969	14294	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-24				AGAATAAACAAACTTTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1443786795002839					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479110	59479160	59013438	59013488	14295	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-25				AATTTCCTCCAGGGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050583021062257989					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479121	59479171	59013449	59013499	14296	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-26				GGGCCTTCCTGGGCCGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59415653157790627					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479452	59479502	59013780	59013830	14297	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-27				TGTTTTTGACTCTGAATTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.015797764732988589					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479479	59479529	59013807	59013857	14298	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-28				ACTCCTCCTTCCCCGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0048408577810121686					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479149	59479199	59013477	59013527	14299	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-29				AAACTGCAAGGAGCTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2229979680265381					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479391	59479441	59013719	59013769	14300	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-3				CTCCAGAAAGCAAACGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20591127601992179					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479551	59479601	59013879	59013929	14301	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-30				TCTTTTTTCAGAAATAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.827780024178207					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479540	59479590	59013868	59013918	14302	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-31				TCTGAAAAAAGAAATAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.2698346168271391					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479083	59479133	59013411	59013461	14303	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-4				TAGCCCGGTGCCCTTGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00033219217526190967					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479419	59479469	59013747	59013797	14304	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-5				ACGCCACCAGGGACGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46848372952051109					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479419	59479469	59013747	59013797	14305	hg38	N/A	enh11918	fant1764	Enhatls6781	enhancer	JUNe+10-5				ACGCCACCAGGGACGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46848372952051109					JUN	chr1	58780790	58784047	229725				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479336	59479386	59013664	59013714	14306	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-6				CAAAGTCAAAGTACCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.326296692220729					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479042	59479092	59013370	59013420	14307	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-7				AATTTACTCACAGCCTAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036392354164235988					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479308	59479358	59013636	59013686	14308	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-8				TCTGATGGGTGACCACCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16126438147292449					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59479195	59479245	59013523	59013573	14309	hg38	N/A	enh11918	N/A	Enhatls6781	enhancer	JUNe+10-9				GAAAGTTCAGCTCGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23604974549029251					JUN	chr1	58780790	58784047	219107				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529203	59529253	59063531	59063581	14310	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-1				TGACCTGTATTCGAGTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0762721698712976					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529437	59529487	59063765	59063815	14311	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-10				GCTTCCGTTTCTGTCACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.001861671240349506					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529325	59529375	59063653	59063703	14312	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-11				AGCTATGTTGGTGTCTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2094673561920882					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529586	59529636	59063914	59063964	14313	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-12				AGTGTCTCAAAACAGAGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28106232128268271					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529368	59529418	59063696	59063746	14314	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-13				GTTTGCAGTTTTCCAATACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18000005598837451					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529337	59529387	59063665	59063715	14315	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-14				GTCTCTGAGGGAATGCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059900649630898813					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529099	59529149	59063427	59063477	14316	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-15				TAACAAGTGTTAGCAATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045794853418490447					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529419	59529469	59063747	59063797	14317	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-16				TCAGGCTGGCTTCTTCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89830708196686582					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529545	59529595	59063873	59063923	14318	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-17				CTGCTGACAAAGAAGGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2231831710029053					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529266	59529316	59063594	59063644	14319	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-18				GGCTAGGAAGAGGAGTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024664933961673369					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529533	59529583	59063861	59063911	14320	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-19				TTTGTCAGCAGCTCCCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027785226756327951					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529492	59529542	59063820	59063870	14321	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-2				CTTGAGAGAGACCGTATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.064738113935846608					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529245	59529295	59063573	59063623	14322	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-20				CAGCTGGTGCTGAGGTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2163725501931098					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529173	59529223	59063501	59063551	14323	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-21				ATTAAAAGGCAGAAACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48645829479018582					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529142	59529192	59063470	59063520	14324	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-22				TGCTGAGGAAACAAAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.963666121652777					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529481	59529531	59063809	59063859	14325	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-23				TTCTTCCTCCTCCTGTCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20513206178210761					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529159	59529209	59063487	59063537	14326	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-24				GAGAGGTTAGAATGATTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58472927635862293					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529127	59529177	59063455	59063505	14327	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-3				GTTAACAACCCCTACTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.145999638608166					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529356	59529406	59063684	59063734	14328	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-4				AAGGCTGCTCCTCCATGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60951678634999018					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529298	59529348	59063626	59063676	14329	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-5				GAGTTTCCTCCAAAGAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0931973084004926					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529381	59529431	59063709	59063759	14330	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-6				AACTGCAAACTGGACTCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044338851480274291					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529519	59529569	59063847	59063897	14331	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-7				CTTTGTTGTCAGGGCCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55756427855707791					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529313	59529363	59063641	59063691	14332	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-8				GGAAACTCCAGCAGCTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32386655150241339					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59529229	59529279	59063557	59063607	14333	hg38	N/A	enh11919	N/A	Enhatls6783	enhancer	JUNe+11-9				ATGCATAGCAATTGCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087967889945630665					FGGY	chr1	59296637	59762730	229981				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543630	59543680	59077958	59078008	14334	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-1				TGTTGAGCCAACATCAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.687803408554824					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543588	59543638	59077916	59077966	14335	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-10				GATGTATCACTCCAGAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29238767535636112					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543764	59543814	59078092	59078142	14336	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-11				GCACTCAGTCATTTTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6559668228695219					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543862	59543912	59078190	59078240	14337	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-12				ATCTCAGCTGATACCACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.159551433528283					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544000	59544050	59078328	59078378	14338	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-13				CCCTCCAGTGGAGCAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67290234725550258					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543646	59543696	59077974	59078024	14339	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-14				AGACTGGTGGGCTCCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.0225763081020882					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543820	59543870	59078148	59078198	14340	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-15				AACTCAATTGCCTCCTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29569316592325551					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544209	59544259	59078537	59078587	14341	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-16				GAAACAACTCATGAAGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.107668296543648					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543742	59543792	59078070	59078120	14342	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-17				CTTGAAAGCACTTCATCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82563911124980771					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543659	59543709	59077987	59078037	14343	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-18				GAGAGCTTTGACTCCTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042578088803891481					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543723	59543773	59078051	59078101	14344	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-19				CAAGACTGTCTGGCACCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.166295366531596					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543689	59543739	59078017	59078067	14345	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-2				AAGCCTTGGTGAGTACCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56604964780438782					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543961	59544011	59078289	59078339	14346	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-20				AATTGCTCATTAACATGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0690536591573649					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544165	59544215	59078493	59078543	14347	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-21				AATGAGGAATGGGGAGCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31037096266294972					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543807	59543857	59078135	59078185	14348	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-22				AGCCCCACTTCACCCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38101550363124009					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544072	59544122	59078400	59078450	14349	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-23				GCTCTTTCTTTCTTAAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4192550471409122					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544264	59544314	59078592	59078642	14350	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-24				GAGGGAGGTTGGTTGGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00124556623317103					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544227	59544277	59078555	59078605	14351	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-25				GTTTCAAGGACTAAACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.828246391194812					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543939	59543989	59078267	59078317	14352	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-26				TGAGTGCTGAGTTTCTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5824515355157075					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544149	59544199	59078477	59078527	14353	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-27				CCTTATTATTTCCTCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39428971664723123					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544241	59544291	59078569	59078619	14354	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-28				ACCAGAAGGAAGTTAGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42493848993326189					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544106	59544156	59078434	59078484	14355	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-29				TCTGCATTTGAATTCTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27704431628917953					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543779	59543829	59078107	59078157	14356	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-3				AACGTAACCACCTAGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0430134271812485					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543988	59544038	59078316	59078366	14357	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-30				TTTTCTCAACAGCCCTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55835860531525738					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543674	59543724	59078002	59078052	14358	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-31				AAGCTCTCCCTGGGCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7013192949144601					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543610	59543660	59077938	59077988	14359	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-32				ACAGAAGTGGATCTGAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40905692241479252					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544057	59544107	59078385	59078435	14360	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-33				GAAAGAGCAAGGTTGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.37754643544628					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544253	59544303	59078581	59078631	14361	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-34				TTAGCAAGAGGGAGGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0034118865322341					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544176	59544226	59078504	59078554	14362	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-35				CTCATTTTACAAATGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.987243586731086					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543703	59543753	59078031	59078081	14363	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-4				AGGTATCATCGCAGAAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20348832572760461					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543846	59543896	59078174	59078224	14364	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-5				TATTTGAGCTGAGAGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062654107358577987					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543906	59543956	59078234	59078284	14365	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-6				ACAAAAGCTCTGGTTAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14286622121559739					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59543880	59543930	59078208	59078258	14366	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-7				GAGATAACTATCTCAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62092185707817127					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544122	59544172	59078450	59078500	14367	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-8				GGCTAGGACATTCACTTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.691281618387569					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59544037	59544087	59078365	59078415	14368	hg38	N/A	enh47182	N/A	Enhatls6783	enhancer	JUNe+12-9				GGGGGCAATCTGAATGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51496582471640229					FGGY	chr1	59296637	59762730	214675				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6229	chr1	59566537	59566587	59100865	59100915	14369	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-1				GATCATTGACACCTTGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35036097607561051					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566482	59566532	59100810	59100860	14370	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-10				CTCATTTATGCATATATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22088789776275039					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566581	59566631	59100909	59100959	14371	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-11				CAAGTGAAGGCAATTATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53583337371441919					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566718	59566768	59101046	59101096	14372	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-12				CAAATGAGCTAGAGAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32755852389349172					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566828	59566878	59101156	59101206	14373	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-13				CATTTCCAAGCACATTCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13092800027173859					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566639	59566689	59100967	59101017	14374	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-14				GTAGGATATTGCAAAAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39782922713734908					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566817	59566867	59101145	59101195	14375	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-15				ACATTCATGTGGCTGTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1420293916335674					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566741	59566791	59101069	59101119	14376	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-16				ATGGCAGCTGGCTTCTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51781759993103449					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566526	59566576	59100854	59100904	14377	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-17				GTGGTAGGGAGCCTCTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55402373883278988					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566660	59566710	59100988	59101038	14378	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-18				GGGATGTCACTACTCAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1016866154179058					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566689	59566739	59101017	59101067	14379	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-19				AAAGTCTGTGGCTTCTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59609678624985751					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566593	59566643	59100921	59100971	14380	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-2				GCCTTCACTTGATTGTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50662210902213711					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566677	59566727	59101005	59101055	14381	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-20				ATTAGGTTACAAAAAGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62286061846274487					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566561	59566611	59100889	59100939	14382	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-21				AGGGTGTGAATACCAAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33529362801341828					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566621	59566671	59100949	59100999	14383	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-3				GTGACTATCTTCTAATGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0091065394002071542					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566510	59566560	59100838	59100888	14384	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-4				CTACCACAGCATTTCTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17807737070733831					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566774	59566824	59101102	59101152	14385	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-5				ACCCTCTGGATGTCTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038425598727143163					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566800	59566850	59101128	59101178	14386	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-6				GGAAGGCCTCAAGTTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12623639620241031					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566549	59566599	59100877	59100927	14387	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-7				TGTCAATGATCTCCACCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14489887829290329					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566760	59566810	59101088	59101138	14388	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-8				CCATGTTGTGATCCACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31319443141951619					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59566789	59566839	59101117	59101167	14389	hg38	N/A	enh42973	N/A	Enhatls6784	enhancer	JUNe+13-9				AGTTTTTGCTGGCTGCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087470057428286924					FGGY	chr1	59296637	59762730	186835				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582918	59582968	59117246	59117296	14390	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-1				GTGTCGTGTTGGTGGTGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55721392580311857					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582776	59582826	59117104	59117154	14391	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-10				GCAGTGAGTCACTGCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.97711724944792344					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582687	59582737	59117015	59117065	14392	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-11				CAAAGACATAAGACTCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.129632609862074					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582979	59583029	59117307	59117357	14393	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-12				GAAATATGCTAGAGAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.308914182342879					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582754	59582804	59117082	59117132	14394	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-13				GCTGCAGCCAAGAGCGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42062757612576368					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582740	59582790	59117068	59117118	14395	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-14				GGCTGCAGCCTCCTTCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24593731344729189					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582874	59582924	59117202	59117252	14396	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-15				CTCTTTTATCACCAAAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2629235166237523					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582729	59582779	59117057	59117107	14397	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-16				CAAGAGCCCAGCCCAATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70778864262783037					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582945	59582995	59117273	59117323	14398	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-17				TAAAACAGAGAGGAGCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96866379358635035					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582857	59582907	59117185	59117235	14399	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-18				AAAGAGGAAAGTCACATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24095990169815951					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582885	59582935	59117213	59117263	14400	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-19				AGAGCATTTTACCAAAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35715506304662242					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582555	59582605	59116883	59116933	14401	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-2				ACATAGCCCCAAAAGCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042678594979886013					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582704	59582754	59117032	59117082	14402	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-20				TCTTTGAATTGGGGAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43953140450732209					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582638	59582688	59116966	59117016	14403	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-21				TTTCTCTTTTACAACATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582814	59582864	59117142	59117192	14404	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-22				AATGTCAGACAGCATGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33226409835575688					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582674	59582724	59117002	59117052	14405	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-3				CTCTGACAGGGGCTGACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18302443774429369					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582570	59582620	59116898	59116948	14406	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-4				GGCTATGTAATTATAGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.051388248617293852					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582907	59582957	59117235	59117285	14407	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-5				TGTACAGAGCAGTGTCGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.028183177145012291					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582540	59582590	59116868	59116918	14408	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-6				GCTAAAAAAGTCACTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23658700486291939					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582597	59582647	59116925	59116975	14409	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-7				TCTTGCCCTTTCCCATCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01041605719033052					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582586	59582636	59116914	59116964	14410	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-8				GTGCTGGGGCTCCTCTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2157942657167124					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6229	chr1	59582790	59582840	59117118	59117168	14411	hg38	N/A	N/A	N/A	Enhatls6784	enhancer	JUNe+14-9				ATTCATCCTCCGCCCCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31195979469074792					FGGY	chr1	59296637	59762730	170382				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6228
enhrx-6231	chr1	59650366	59650416	59184694	59184744	14412	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-1				CAAGGTGCTTGTTCGTGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019865987271347571					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650475	59650525	59184803	59184853	14413	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-10				GACTGTTGTAAGCTATGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78987330668666433					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650425	59650475	59184753	59184803	14414	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-11				CAAGTGAGAGACTGCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1716863173942261					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650128	59650178	59184456	59184506	14415	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-12				GCTTCATCTCTGGTTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35540583508371948					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650412	59650462	59184740	59184790	14416	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-13				CTCTCACTTGGGAATTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26271412807678463					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650622	59650672	59184950	59185000	14417	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-14				AACAAAGCTTGCATCACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1075584255599915					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650150	59650200	59184478	59184528	14418	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-15				TTGCACCATTCCTACAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24470729299616609					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650174	59650224	59184502	59184552	14419	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-16				AACAAGTTGGAAGTCACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054161927405967612					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650637	59650687	59184965	59185015	14420	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-17				ACTCCTGGTCTCCCCAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20198209967029029					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650161	59650211	59184489	59184539	14421	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-18				GGAATGGTGCAAAAACAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029884091047041011					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650095	59650145	59184423	59184473	14422	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-19				TATTCCATTTCCAGCCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14552956043247389					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650454	59650504	59184782	59184832	14423	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-2				GGACGTTATCAGTCCCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.625764852914906					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650326	59650376	59184654	59184704	14424	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-20				CCTAATGCTTGTGGCTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31076611498728179					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650577	59650627	59184905	59184955	14425	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-21				CAAGAAACTTGTTCAAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73607389647512844					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650592	59650642	59184920	59184970	14426	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-22				GTTTCTTGCTTATGTGAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54567293108075032					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650238	59650288	59184566	59184616	14427	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-23				TCTCTTACCTAATAGTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26310269486169718					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650214	59650264	59184542	59184592	14428	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-24				ATGTAGTCAGGTGAGTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.0456646481386862					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650521	59650571	59184849	59184899	14429	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-25				TACTCTATATATTTGTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62195701846199714					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650384	59650434	59184712	59184762	14430	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-26				GAGGACTGAGTTCTTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20078690645286049					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650507	59650557	59184835	59184885	14431	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-27				GTGATGAGGATCAAAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46045403851806738					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650200	59650250	59184528	59184578	14432	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-28				GTGGGGTGGCTCTGCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03085605545297742					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650441	59650491	59184769	59184819	14433	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-29				CTGCAGGAAGCAGCCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.071561147157282678					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650287	59650337	59184615	59184665	14434	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-3				TGTACCAGGGATCCCTACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0612209011139491					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650081	59650131	59184409	59184459	14435	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-30				TTGCTTCTTTTTCTCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18875935625693729					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650649	59650699	59184977	59185027	14436	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-4				TGCCACGGAGCTCCTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0792621403835994					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650664	59650714	59184992	59185042	14437	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-5				CATGTAGCCTCACGCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1209700705661822					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650275	59650325	59184603	59184653	14438	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-6				TTTCACGTAAGTCCAGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13649401651893739					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650314	59650364	59184642	59184692	14439	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-7				CAAGCATTAGGTAGGGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66133185357873048					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650301	59650351	59184629	59184679	14440	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-8				GGGTACAGGGTAAGTGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072671622164771077					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59650226	59650276	59184554	59184604	14441	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+15-9				TAGTCCAGAGGAATGTAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18861821402544379					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652541	59652591	59186869	59186919	14442	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-1				GTGTCTAACATACACCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68110978059176341					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652556	59652606	59186884	59186934	14443	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-10				TTAGACACTGCCTGCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42924560172261439					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652246	59652296	59186574	59186624	14444	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-11				TGCTTGGGTACACACATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27290745935779909					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652222	59652272	59186550	59186600	14445	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-12				GCCAGAGATTCAACAGCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23206224029900741					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652364	59652414	59186692	59186742	14446	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-13				GAGTAGGTTTGCAGAGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2300942070226473					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652442	59652492	59186770	59186820	14447	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-14				GAATTCTCATTCACCAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51332520463658282					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652466	59652516	59186794	59186844	14448	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-15				TTCTGGAGGGGCTGAACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12407429184718891					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652417	59652467	59186745	59186795	14449	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-16				GGTCACTGGGGAGTAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34926032266831808					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652453	59652503	59186781	59186831	14450	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-17				GAATGAGAATTCTTTCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3205216910252291					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652430	59652480	59186758	59186808	14451	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-18				ACCAGGGTGGGGAGGTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1946990094657526					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652265	59652315	59186593	59186643	14452	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-19				CTGGATTCCAAGATCCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17312298057583361					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652527	59652577	59186855	59186905	14453	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-2				GAATCTGACTAAGGCCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28090984834197591					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652321	59652371	59186649	59186699	14454	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-20				ACAGGCAGGCTGTCAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19602995443919979					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652567	59652617	59186895	59186945	14455	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-21				CTGCAAGCTTGGAGGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24100757526082719					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652406	59652456	59186734	59186784	14456	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-22				AGTAATGAGGGGTGGTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.218797977104509					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652207	59652257	59186535	59186585	14457	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-3				GCATATGGTCCACAATAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2957112349566251					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652279	59652329	59186607	59186657	14458	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-4				AAGATAAGTCTGACCCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13364567002575589					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652590	59652640	59186918	59186968	14459	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-5				ACTCAGCTAGCTCATCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.046197518483445811					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652339	59652389	59186667	59186717	14460	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-6				TGGGAAGGAACGAATGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15959166730659591					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652380	59652430	59186708	59186758	14461	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-7				TCCAACACAGCGGGTGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.341061837049306					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652614	59652664	59186942	59186992	14462	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-8				TGAGTAACTATCTATTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64664960326155574					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6231	chr1	59652499	59652549	59186827	59186877	14463	hg38	N/A	enh26747	N/A	Enhatls6787	enhancer	JUNe+16-9				GGATGTCATAACAGGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18546557904202529					FGGY	chr1	59296637	59762730	105895				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6230
enhrx-6248	chr1	60235173	60235223	59769501	59769551	14464	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-1				ATGTACGGTCAGTTCTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047704005327494838					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235041	60235091	59769369	59769419	14465	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-10				CTTGGCTGTCCTTTAAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57946535605545058					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235130	60235180	59769458	59769508	14466	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-11				CATATGGTTTAACTTGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3758303170402808					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235295	60235345	59769623	59769673	14467	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-12				GAACTGGATTTGGCCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.159688386997499					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235206	60235256	59769534	59769584	14468	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-13				GCCCTAGCAGGGAAACTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24878107535056221					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235188	60235238	59769516	59769566	14469	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-14				GAGGGCAAAGCAGATATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.426798634664052					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235346	60235396	59769674	59769724	14470	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-15				GGTCTGCCTGGGTTAAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85071715594667474					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235236	60235286	59769564	59769614	14471	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-16				TAAGTGAAAGGCTATCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1884496523561709					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235367	60235417	59769695	59769745	14472	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-17				CTCTTGGATTTTTCTCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024847159555305878					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235383	60235433	59769711	59769761	14473	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-18				AAAATATGGTTTAAGACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33807890090825932					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235146	60235196	59769474	59769524	14474	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-2				AGGTAGATAAGCCTTCCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12308070820320111					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235317	60235367	59769645	59769695	14475	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-3				TTGGTGGCGGGAGAATTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4166376102565344					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235112	60235162	59769440	59769490	14476	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-4				ATAGGGCTTTCTGGGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68968406448046649					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235218	60235268	59769546	59769596	14477	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-5				ACTTAACATTTGGCCCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02492583216077111					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235330	60235380	59769658	59769708	14478	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-6				AACAAGGCCCAAGTTGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.175353320968496					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235097	60235147	59769425	59769475	14479	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-7				GTTATTTCTCCCATCCCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27501299331146017					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235282	60235332	59769610	59769660	14480	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-8				TTATCAGCTATCTCCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.751973612528961					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-6248	chr1	60235073	60235123	59769401	59769451	14481	hg38	N/A	enh74229	N/A	N/A	enhancer	JUNe+17-9				TATAAGTCAGACTAGCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46067166877361682					FGGY	chr1	59296637	59762730	5019				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6247
enhrx-lit130	chr1	60463330	60463380	59997658	59997708	14482	hg38					enhancer	JUNe+18-1				AATGTGAGACGTGGATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2543058958837574													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit131	chr1	60463430	60463480	59997758	59997808	14483	hg38					enhancer	JUNe+18-10				TTGCAGGCTGAAGTTTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058738745472386757													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit132	chr1	60463355	60463405	59997683	59997733	14484	hg38					enhancer	JUNe+18-11				TCAGCCTTGTTCTTCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28870284817191411													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6281	chr1	60463251	60463301	59997579	59997629	14485	hg38	N/A	N/A	N/A	Enhatls6843	enhancer	JUNe+18-12				ATGAATTGTAAAGCTGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.132148016639752					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6280
enhrx-6282	chr1	60463473	60463523	59997801	59997851	14486	hg38	N/A	N/A	N/A	Enhatls6844	enhancer	JUNe+18-13				TTGGTAGAAAACTCCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46550344085290629					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6281
enhrx-6282	chr1	60463460	60463510	59997788	59997838	14487	hg38	N/A	N/A	N/A	Enhatls6844	enhancer	JUNe+18-14				TCTGGCTGCAGCTCCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047095815177218468					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6281
enhrx-lit133	chr1	60463379	60463429	59997707	59997757	14488	hg38					enhancer	JUNe+18-15				TTCACGAAGGGCTGGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40161693476851229													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6281	chr1	60463196	60463246	59997524	59997574	14489	hg38	N/A	N/A	N/A	Enhatls6843	enhancer	JUNe+18-16				TCAAGAGGCAAAAGAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.011837143036725921					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6280
enhrx-6282	chr1	60463490	60463540	59997818	59997868	14490	hg38	N/A	N/A	N/A	Enhatls6844	enhancer	JUNe+18-17				TACCAAAACAACAAAAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31425165940945932					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6281
enhrx-6281	chr1	60463238	60463288	59997566	59997616	14491	hg38	N/A	N/A	N/A	Enhatls6843	enhancer	JUNe+18-2				CTGGCATAGGTTTCTATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29738231713342222					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6280
enhrx-6281	chr1	60463221	60463271	59997549	59997599	14492	hg38	N/A	N/A	N/A	Enhatls6843	enhancer	JUNe+18-3				TTGTGGTCTAGTCTAAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43468942855757531					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6280
enhrx-lit134	chr1	60463366	60463416	59997694	59997744	14493	hg38					enhancer	JUNe+18-4				CTTCACAGCTGGATTCACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071234987613228051													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit135	chr1	60463394	60463444	59997722	59997772	14494	hg38					enhancer	JUNe+18-5				GAGACTGGCCTGATCTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30696350425334362													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6282	chr1	60463442	60463492	59997770	59997820	14495	hg38	N/A	N/A	N/A	Enhatls6844	enhancer	JUNe+18-6				GTTTCAGCAGGAGAGCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22784220382788489					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6281
enhrx-lit136	chr1	60463280	60463330	59997608	59997658	14496	hg38					enhancer	JUNe+18-7				CTGTGTGATCTGAGTAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6181818528451487													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit137	chr1	60463317	60463367	59997645	59997695	14497	hg38					enhancer	JUNe+18-8				GATAGACAGGTTCAGGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29018362323077362													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit138	chr1	60463414	60463464	59997742	59997792	14498	hg38					enhancer	JUNe+18-9				AGGTTTCAGAGGATCTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41933421224162931													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-6289	chr1	60518701	60518751	60053029	60053079	14499	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-1				TTTGCTAGCTCGGCAGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3861273979258189					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518810	60518860	60053138	60053188	14500	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-10				GAGCAGTTTGATGTATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2718846675939855					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518639	60518689	60052967	60053017	14501	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-11				TCTAGTGGGAGGCTCAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1014110837422619					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518654	60518704	60052982	60053032	14502	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-12				GAACTCAACAGGGTTTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.03093453958934363					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518728	60518778	60053056	60053106	14503	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-13				TGTTCTTAACCTCCATGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3695594346666557					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518615	60518665	60052943	60052993	14504	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-14				TAACACTCTGCCACCAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.073022545953634471					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518501	60518551	60052829	60052879	14505	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-15				GTAATGAGGGTCTCTGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090966896987241586					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518407	60518457	60052735	60052785	14506	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-16				TCATCTATGTGTGAGTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.168888493484478					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518536	60518586	60052864	60052914	14507	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-17				TGTGGTGCTGGCCCGCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.116726706528418					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518602	60518652	60052930	60052980	14508	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-18				CCCACAAGGCCTTCCTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.444523148307354					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518756	60518806	60053084	60053134	14509	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-19				CCTAATGAACATGCTACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88709998735588191					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518488	60518538	60052816	60052866	14510	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-2				CTTAGTCAAGCTGGTAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.155293831088741					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518261	60518311	60052589	60052639	14511	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-20				TTCGAACTTACTCTGTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39596676510197459					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518307	60518357	60052635	60052685	14512	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-21				AGACTGAGCTAACATGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33449509676577571					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518521	60518571	60052849	60052899	14513	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-22				AGGCAACTGTGGCTGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.279697734456939					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518141	60518191	60052469	60052519	14514	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-23				TACAAACCTTCCTTTCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042304557857625519					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518797	60518847	60053125	60053175	14515	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-24				CAAACTGCTCATTCCTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38262694832476463					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518716	60518766	60053044	60053094	14516	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-25				CTAGCAAATAATCCAGATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56822635594275528					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518344	60518394	60052672	60052722	14517	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-26				TCTTTTGGAGCAAATTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1175690296102174					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518329	60518379	60052657	60052707	14518	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-27				TTTATCAGCAACTTCTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35471353613663481					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518547	60518597	60052875	60052925	14519	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-28				GCCAGCACCACACGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.014101639165184509					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518666	60518716	60052994	60053044	14520	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-29				CTGTTGAGTTCTGGGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0766580710191347					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518245	60518295	60052573	60052623	14521	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-3				GTTCGAAGAGTCTCATTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49240021524576971					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518386	60518436	60052714	60052764	14522	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-30				GAAAATAAGCTTTCCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.459546649648348					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518191	60518241	60052519	60052569	14523	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-31				TTCTTATATACACAAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.388330659863398					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518429	60518479	60052757	60052807	14524	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-32				GATCTAGAAAGAGTTCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28034592929426921					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518129	60518179	60052457	60052507	14525	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-33				TTTCACAAAGGAAGAATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54762404125609521					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518579	60518629	60052907	60052957	14526	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-4				AGGTGTGGGGACCGACTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13647264540132251					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518772	60518822	60053100	60053150	14527	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-5				TCTGCATTCGCCATTACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53260837372645475					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518368	60518418	60052696	60052746	14528	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-6				CTGGGACGTAACAGGCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090880157028803837					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518562	60518612	60052890	60052940	14529	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-7				AATTGGTTCTGTCTGCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28371156277873211					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518452	60518502	60052780	60052830	14530	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-8				TGTGCTTTTGTAACTGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1532569314609494					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6289	chr1	60518784	60518834	60053112	60053162	14531	hg38	N/A	N/A	N/A	Enhatls6851	enhancer	JUNe+19-9				GCGAATGCAGAGTCCATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40184073025352318					C1orf87	chr1	59990393	60073770	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6288
enhrx-6228	chr1	59281114	59281164	58815442	58815492	14532	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-1				TGGTGCTACGGCCGCTACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2752016811022569					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281053	59281103	58815381	58815431	14533	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-10				TTCCGCCCACAGGTCGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.060969887220826247					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281095	59281145	58815423	58815473	14534	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-11				ACCAGTTCCCGCCTCCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0018247038266930649					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281017	59281067	58815345	58815395	14535	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-12				TTTACACAGAGGGCAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0474466998506129					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280817	59280867	58815145	58815195	14536	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-13				TTTGATCCTCAAATGGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13565650952274991					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281183	59281233	58815511	58815561	14537	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-14				CGGGGAGCCACGGGGCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0052911557157245531					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281169	59281219	58815497	58815547	14538	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-15				GGCTCCCCGGCCCTGCGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24016336040132261					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281268	59281318	58815596	58815646	14539	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-16				ACCATGTTCTGAGTGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40939716791836472					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281268	59281318	58815596	58815646	14540	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+2-16				ACCATGTTCTGAGTGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40939716791836472					JUN	chr1	58780790	58784047	31564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280929	59280979	58815257	58815307	14541	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-17				TTTATTCACAGATTCCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25898249871098411					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280838	59280888	58815166	58815216	14542	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-18				GGGCGAGTGGGCGGATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52588902549771066					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281137	59281187	58815465	58815515	14543	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-19				GGCGGGCTCCGAGCCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.653437378968539					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280987	59281037	58815315	58815365	14544	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-2				GCCAGCGATTCGTCCTTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42034947829067187					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280887	59280937	58815215	58815265	14545	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-20				ATGCATTGAAATTCCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37038707082241812					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281247	59281297	58815575	58815625	14546	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-21				GGAGAAGGGTGCTCATGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094066178464779951					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281247	59281297	58815575	58815625	14547	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+2-21				GGAGAAGGGTGCTCATGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094066178464779951					JUN	chr1	58780790	58784047	31564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281071	59281121	58815399	58815449	14548	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-22				GCAGGTCCCGCCCGCAGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.033270610114043239					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281158	59281208	58815486	58815536	14549	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-23				CCACGCCCCAGCCCTCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38545083180230538					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281082	59281132	58815410	58815460	14550	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-24				TCCCCCGCGGCCCGGCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42440099959185662					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281028	59281078	58815356	58815406	14551	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-25				CTGTGGCTTTATTTACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.055302903462223607					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281207	59281257	58815535	58815585	14552	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-26				GGAGCAGGTGGAAGAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31050339214249928					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280961	59281011	58815289	58815339	14553	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-27				CCTTTCCTGGCCTCCCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4905887017849499					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281195	59281245	58815523	58815573	14554	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-28				GGGCCAAAAGGAGGAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62242147914395463					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280914	59280964	58815242	58815292	14555	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-29				TGAATAAATAAATACGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8749281406587941					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280976	59281026	58815304	58815354	14556	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-3				CGAATCGCTGGCGGGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.090141941377579138					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280943	59280993	58815271	58815321	14557	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-4				AAAGGCGGCCTTCGCCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0787244853088831					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281225	59281275	58815553	58815603	14558	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-5				GGACTCCGACGGTCTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7432249904135797					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281125	59281175	58815453	58815503	14559	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-6				GCCTCCCGAGGCCTGCGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084990719907712245					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281236	59281286	58815564	58815614	14560	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-7				CTCATGGGTGGGGACTCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87936383131948714					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281236	59281286	58815564	58815614	14561	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+2-7				CTCATGGGTGGGGACTCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87936383131948714					JUN	chr1	58780790	58784047	31564				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59280870	59280920	58815198	58815248	14562	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-8				GAATGCGTTTCTGTGATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.413323138422634					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281000	59281050	58815328	58815378	14563	hg38	N/A	enh388	fant1754	Enhatls6778	enhancer	JUNe+2-9				CCTTACAAGGCTAGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85747964620743311					JUN	chr1	58780790	58784047	31039				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6292	chr1	60622807	60622857	60157135	60157185	14564	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-1				TTCACGTGAGAGTTGTATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92437115038404					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622527	60622577	60156855	60156905	14565	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-10				AAGTAGCCAACTACAAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79803524287810679					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622711	60622761	60157039	60157089	14566	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-11				GTGGCCAAGTCAGCCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1212715288933409					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622698	60622748	60157026	60157076	14567	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-12				GGTTAAGGGAGGGCCTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.08789628715918					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622834	60622884	60157162	60157212	14568	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-13				GATGAAATAGCATTTGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2489758288187976					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622762	60622812	60157090	60157140	14569	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-14				AGAATTCTGGGACTTGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63314763906620153					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622636	60622686	60156964	60157014	14570	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-15				TTCTAAGGAAGGCACCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17582631105551511					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622651	60622701	60156979	60157029	14571	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-16				CAGCCTTCTCAGACTTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10263205639315789					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622586	60622636	60156914	60156964	14572	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-17				CTACCAGCAGCTCCCCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27278984638582388					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622622	60622672	60156950	60157000	14573	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-18				CTTTGCTGTCCTATCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32599649856854079					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622562	60622612	60156890	60156940	14574	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-2				GTCTATTAGCTCTCTACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21368107585665361					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622853	60622903	60157181	60157231	14575	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-3				GAGGTTTTGTCTGCTCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25198894290067692					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622600	60622650	60156928	60156978	14576	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-4				GAAAGAACCAACCACCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47959294431187932					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622515	60622565	60156843	60156893	14577	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-5				ACAAAACTAGGCTGTGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040908114834950243					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622671	60622721	60156999	60157049	14578	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-6				CTGGTGAGCCTCCAACCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25089725415235792					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622730	60622780	60157058	60157108	14579	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-7				GCTGCAAGACTGACACCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39734365913170661					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622684	60622734	60157012	60157062	14580	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-8				AACCTGTGGGAGGTGGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27930284746688949					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6292	chr1	60622750	60622800	60157078	60157128	14581	hg38	N/A	N/A	N/A	Enhatls6854	enhancer	JUNe+20-9				AGCACTGATGTGAGAATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065162446956533282					C1orf87	chr1	59990393	60073770	82254				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6291
enhrx-6228	chr1	59281998	59282048	58816326	58816376	14582	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-1				GTAATCGCAGGCAATCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39144345071640041					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281876	59281926	58816204	58816254	14583	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-10				AGATTTCTGGGATCCGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21155873532608471					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281822	59281872	58816150	58816200	14584	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-11				TCTCTCAATGGGACTCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47365303619042948					JUN	chr1	58780790	58784047	31861				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282302	59282352	58816630	58816680	14585	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-12				GCGTTCCTATGGCCAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47237218404839421					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282107	59282157	58816435	58816485	14586	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-13				TCGCACCGAGGGAACCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.5809278599953984					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281905	59281955	58816233	58816283	14587	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-14				AAACCGGCGCCCCCACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1849445180850819					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282161	59282211	58816489	58816539	14588	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-15				ACAACGGCCGGCAGGACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26888034752949791					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282119	59282169	58816447	58816497	14589	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-16				TGCCGCGCGCGCTCGCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0857848207107596					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281921	59281971	58816249	58816299	14590	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-17				GAGGAAAGCTCTTCGCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25427511503814881					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281965	59282015	58816293	58816343	14591	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-18				GTCGCTCAGCCAGCCAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.430919069524294					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281940	59281990	58816268	58816318	14592	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-19				AAATCAGCAGTAGCTGTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62921852670499678					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282177	59282227	58816505	58816555	14593	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-2				CCGTTGTAAACTGGCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24703797533251731					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282177	59282227	58816505	58816555	14594	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-2				CCGTTGTAAACTGGCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24703797533251731					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282219	59282269	58816547	58816597	14595	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-20				TGGGGCCGCCGGTGGGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53529741784226126					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282265	59282315	58816593	58816643	14596	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-21				CGAGGACTGAGGATTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3954106431666205					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282290	59282340	58816618	58816668	14597	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-22				CAGTCCTCAGGTCCAAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59290352213122832					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281863	59281913	58816191	58816241	14598	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-23				TGGGAGAAGACTGAGATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043373644427107921					JUN	chr1	58780790	58784047	31861				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281863	59281913	58816191	58816241	14599	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-23				TGGGAGAAGACTGAGATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043373644427107921					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282071	59282121	58816399	58816449	14600	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-24				CGGGCACAGAGCCCAGACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4958750294039189					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282052	59282102	58816380	58816430	14601	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-25				GAACGGCCGGGGAGGGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.09558570205752065					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282246	59282296	58816574	58816624	14602	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-26				CTGGGTCTCTGGGGCCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.249955933390769					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282145	59282195	58816473	58816523	14603	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-27				CCTGCTTTTGCTCCTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01062065282202518					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281844	59281894	58816172	58816222	14604	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-28				AGAGAGGCAGAGCCGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5722403432704151					JUN	chr1	58780790	58784047	31861				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281844	59281894	58816172	58816222	14605	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-28				AGAGAGGCAGAGCCGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5722403432704151					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282232	59282282	58816560	58816610	14606	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-29				GGCGGCCCCAGAGCCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32804588853248862					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281986	59282036	58816314	58816364	14607	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-3				GGGCGATTCTGAGTAATCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2673872358603151					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281833	59281883	58816161	58816211	14608	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-30				CTCTGCCTCTCTCTCTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27602649475740559					JUN	chr1	58780790	58784047	31861				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281833	59281883	58816161	58816211	14609	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-30				CTCTGCCTCTCTCTCTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27602649475740559					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281795	59281845	58816123	58816173	14610	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-31				AGTTTGCCCATCTGTGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1736902720721468					JUN	chr1	58780790	58784047	31861				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59281894	59281944	58816222	58816272	14611	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-4				TTGGGGTGTTTCCGCTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20269025919851461					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282041	59282091	58816369	58816419	14612	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-5				GACTCGCGGGCGAACGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1180645697023493					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282205	59282255	58816533	58816583	14613	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-6				GGTTAGCGGGCCTGGAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1161001046209232					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282205	59282255	58816533	58816583	14614	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-6				GGTTAGCGGGCCTGGAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1161001046209232					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282278	59282328	58816606	58816656	14615	hg38	N/A	enh388	N/A	Enhatls6778	enhancer	JUNe+3-7				TCAGTCCTCGTACAGTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1829595099593852					JUN	chr1	58780790	58784047	32500				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282083	59282133	58816411	58816461	14616	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-8				GCCCCGCCTTTGCCGGCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32725652181840231					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59282028	59282078	58816356	58816406	14617	hg38	N/A	enh388	fant1756	Enhatls6778	enhancer	JUNe+3-9				TAAAAGCGAAAGGGACTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.058041250061690787					JUN	chr1	58780790	58784047	32155				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314689	59314739	58849017	58849067	14618	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-1				GGGCTGGCCTTAACCGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.080428620410784					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314545	59314595	58848873	58848923	14619	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-10				TGTGATAGTGTGTCATCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23359176037125209					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314464	59314514	58848792	58848842	14620	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-11				GAACAGATAGTCAAGGACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.022701087035446189					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314878	59314928	58849206	58849256	14621	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-12				ATTCAACTGATAAAGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49399699254822771					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314755	59314805	58849083	58849133	14622	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-13				GACCTCTGGCTGCAGCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045527027305428409					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314813	59314863	58849141	58849191	14623	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-14				TGGATCCTGGCAGATGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4327451218163					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314676	59314726	58849004	58849054	14624	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-15				ACACTGAGCTGTCCCCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30909296647664158					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314742	59314792	58849070	58849120	14625	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-16				GCCAGAGGTCTGTGCCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44245692430677153					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314709	59314759	58849037	58849087	14626	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-17				AGGAGAGGTGGGCGGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.83098941405148341					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314909	59314959	58849237	58849287	14627	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-18				ATGGGAGAGAAATTCAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0627587999623986					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314729	59314779	58849057	58849107	14628	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-19				GCCAAGAAGGCAGCGGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02049063618702553					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314606	59314656	58848934	58848984	14629	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-2				TCGTGGGAGGCCTATCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22558673175499031					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314646	59314696	58848974	58849024	14630	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-20				AGGCTGAGCCTCTGCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71117816072843076					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314513	59314563	58848841	58848891	14631	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-21				CAGATGATAGAAAATTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1111453282504738					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314635	59314685	58848963	58849013	14632	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-22				CTGCTCCAAGGGCCTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04886174654140573					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314497	59314547	58848825	58848875	14633	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-3				CAGACTTGTGCTTGGACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.223640496812735					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314571	59314621	58848899	58848949	14634	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-4				AAGGCCACCTGAGTCTATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54343511502514075					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314780	59314830	58849108	58849158	14635	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-5				GAGTGAGTAATTCTGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2892456678159358					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314833	59314883	58849161	58849211	14636	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-6				AGACTACAAAGCCCTCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4930838262016588					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314593	59314643	58848921	58848971	14637	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-7				GGGAAAGCTTCCTTCGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35656921605063091					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314797	59314847	58849125	58849175	14638	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-8				TCACTCGCAGATTCTTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86408309880761447					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59314620	59314670	58848948	58848998	14639	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+4-9				TCTGAATGGATGTGGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16691349216716611					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319180	59319230	58853508	58853558	14640	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-1				CCACGGGGTTGCAAACTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1356070767830273					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319384	59319434	58853712	58853762	14641	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-10				GACTTTTACCACAAAGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4553657687666543					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319447	59319497	58853775	58853825	14642	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-11				TATGTAAAGCAGGACCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67156723468516832					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319290	59319340	58853618	58853668	14643	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-12				TGCTCCTACCACTGATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40224058228533888					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319359	59319409	58853687	58853737	14644	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-13				AAGTAAATTAGGTGATACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5113707042619503					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319165	59319215	58853493	58853543	14645	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-14				CAGGCATGTCTTTGTCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21345925816279909					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319136	59319186	58853464	58853514	14646	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-15				TGCTCCTGCACAGATTCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9054927504283331					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319225	59319275	58853553	58853603	14647	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-16				GCTTTCCTTAGTTTGTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1150549617375366					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319370	59319420	58853698	58853748	14648	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-17				AGCTGTTGGAGAAGTAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21620449363467281					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319429	59319479	58853757	58853807	14649	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-18				GCAGGCAGGACCCACTCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7358840759226648					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319072	59319122	58853400	58853450	14650	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-19				TGGGTGGCGGAAGCTGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45735921302184468					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319494	59319544	58853822	58853872	14651	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-2				TCCTGGAAGTAAACCGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46498967312558231					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319477	59319527	58853805	58853855	14652	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-20				TCATTTAACTCTTCAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08842463025726921					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319307	59319357	58853635	58853685	14653	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-21				AAATGGACAATAATGATACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.933889612586813					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319399	59319449	58853727	58853777	14654	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-22				TAAAAGTCATGGAGATTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13548420930179561					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319097	59319147	58853425	58853475	14655	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-23				TTGGGGAGGTAGGAGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43450026552871529					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319083	59319133	58853411	58853461	14656	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-24				AGCTGGGATGGGGATTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.395749031582401					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319110	59319160	58853438	58853488	14657	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-25				AGAGAATGGGGGAGGGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71164975819542409					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319327	59319377	58853655	58853705	14658	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-3				GGGATCTATAGAGCATTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13703056253530821					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319418	59319468	58853746	58853796	14659	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-4				GAGGGCTATCTCCTGTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38028593018921308					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319507	59319557	58853835	58853885	14660	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-5				AACTATACCATAACCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6053324750510537					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319260	59319310	58853588	58853638	14661	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-6				AGCTATCTAGTTTGCTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54801898194667131					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319036	59319086	58853364	58853414	14662	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-7				TCTGGGCCCCTTTAATTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72277795162337055					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319523	59319573	58853851	58853901	14663	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-8				TATAGTTTGGCCAGTTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1374671743557187					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59319054	59319104	58853382	58853432	14664	hg38	N/A	enh26740	N/A	Enhatls6778	enhancer	JUNe+5-9				ACCCAGCCTACATTATTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24315754880307441					JUN	chr1	58780790	58784047	50367				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362539	59362589	58896867	58896917	14665	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-1				TAGGGCGAGGGCACGCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43631048501616593					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362254	59362304	58896582	58896632	14666	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-10				TCAGTTGATAGCCAGTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.319322574796645					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362314	59362364	58896642	58896692	14667	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-11				GCCAGGTGTGACCAGGTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54470022398036788					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362170	59362220	58896498	58896548	14668	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-12				GTTGTCAGGCCTTCACTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1293725262388071					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362272	59362322	58896600	58896650	14669	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-13				ATCAGTTGAGAAGATGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021158116628488269					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362156	59362206	58896484	58896534	14670	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-14				AGCCACCCTCTCCAGTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26077961827790108					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362359	59362409	58896687	58896737	14671	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-15				CTGAACAAAACTGTAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.086835917172781135					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362239	59362289	58896567	58896617	14672	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-16				TCAACTGAAAATCCTGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50051070586302626					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362372	59362422	58896700	58896750	14673	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-17				TTTTGTTCAGTTGTGCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41185708159579359					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362133	59362183	58896461	58896511	14674	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-18				TGGGGGAATGAAGAGGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44512662756082522					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362505	59362555	58896833	58896883	14675	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-19				TGGCCGCCAGCCCCACCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60198779707518146					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362430	59362480	58896758	58896808	14676	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-2				TTATCGTCTCTATCAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.087672629240479					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362110	59362160	58896438	58896488	14677	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-20				CAGAACTGAGCTCCTGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32692000480420019					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362303	59362353	58896631	58896681	14678	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-21				CTTATTTTTTCCCCAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039710958285330077					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362494	59362544	58896822	58896872	14679	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-22				AGGAGCCTGGGCCAGCGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.277383260399047					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362482	59362532	58896810	58896860	14680	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-23				GGGAGGGCCAGCAGGAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033421499892194291					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362122	59362172	58896450	58896500	14681	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-24				AGAGGCCACAGGCCTGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3843118888017335					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362457	59362507	58896785	58896835	14682	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-25				GGAACAGCTGGGAGGGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61340114343278362					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362188	59362238	58896516	58896566	14683	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-3				TCAGGAAGTCCGGGACAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3719854644899297					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362343	59362393	58896671	58896721	14684	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-4				CGAGAGGTTTTCAATGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47847798935250963					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362331	59362381	58896659	58896709	14685	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-5				AAAACCTCTCGGAGAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47882679156975261					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362520	59362570	58896848	58896898	14686	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-6				GGCGGCCAGTGTTTCCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14351370891094631					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362446	59362496	58896774	58896824	14687	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-7				ACGATAAGAAAGGAACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.026498663153582711					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362218	59362268	58896546	58896596	14688	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-8				GGATATTTCTCCTGTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74631278270492585					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59362413	59362463	58896741	58896791	14689	hg38	N/A	enh11917	N/A	Enhatls6780	enhancer	JUNe+6-9				ATGTGGGCTCTATCAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30226246162890519					JUN	chr1	58780790	58784047	112342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369497	59369547	58903825	58903875	14690	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-1				CGGGTTAACCTTCTATGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045887364811608981					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369161	59369211	58903489	58903539	14691	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-10				CACTGTGATTGTTGTCGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8127208014417453					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369624	59369674	58903952	58904002	14692	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-11				TCATCTACAGACTGTCGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031852633707367919					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369981	59370031	58904309	58904359	14693	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-12				ACACGGGACATCCTCTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33614550646834379					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369548	59369598	58903876	58903926	14694	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-13				AACTGAAATCACGGGCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1079742734031591					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369252	59369302	58903580	58903630	14695	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-14				AGTACTACCCACCTCGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.117417002332528					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369662	59369712	58903990	58904040	14696	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-15				GCGCTCCCCGAGTGGCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1028672099414621					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369398	59369448	58903726	58903776	14697	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-16				CGGGCACTGCCGAGGCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3468701257325057					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369717	59369767	58904045	58904095	14698	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-17				CGCGGAAACCCTCAGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30735085104518561					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369324	59369374	58903652	58903702	14699	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-18				TGGGAGTCTCAGTGGCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070230704418690434					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369236	59369286	58903564	58903614	14700	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-19				ATACATGCTGCTCACTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.023066887021910121					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369578	59369628	58903906	58903956	14701	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-2				AGTCCGGCCCTGCGCAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36288746390165177					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59370012	59370062	58904340	58904390	14702	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-20				TTTCTGGGACCAACAGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2200913964074401					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369964	59370014	58904292	58904342	14703	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-21				ACCAACATGAACTGCAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28680379194444422					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369187	59369237	58903515	58903565	14704	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-22				CTCAATGTATGGTCCCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.411505156096252					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369757	59369807	58904085	58904135	14705	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-23				TGCTTTCACTGGCCCGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.853177171501684					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369929	59369979	58904257	58904307	14706	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-24				TTCCTTCTGAGAAAGAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2474221070407597					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369528	59369578	58903856	58903906	14707	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-25				CGGCCCCCACCAGTCCTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10277424591916751					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369685	59369735	58904013	58904063	14708	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-26				GCCGAGCCAGTGCAGCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3297805800566469					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369174	59369224	58903502	58903552	14709	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-27				AATCACAGTGACACCATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.162211761530083					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369992	59370042	58904320	58904370	14710	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-28				AAAAATGTCCCCCCACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.308669224281754					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369768	59369818	58904096	58904146	14711	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-29				ATAAAGCCTGCTGCTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10715724041601581					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369785	59369835	58904113	58904163	14712	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-3				CTTTATGCGGCTGTCGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1033269309132981					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369383	59369433	58903711	58903761	14713	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-30				CCGCCCGGCTTCCCGCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0933084526635181					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369357	59369407	58903685	58903735	14714	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-31				GCGGGACGTGGCCTCGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7051448845273529					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369474	59369524	58903802	58903852	14715	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-32				GCGCTCCGCCCGGCCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2375560891303832					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369562	59369612	58903890	58903940	14716	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-33				ATTTCAGTTTCCGAAGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50336722606453632					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369798	59369848	58904126	58904176	14717	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-34				TCGGGCTCGGGGCGAGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73667358752854883					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369734	59369784	58904062	58904112	14718	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-35				TCCGCGGGCCCTGACCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.243917238663412					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369817	59369867	58904145	58904195	14719	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-36				CCGGCTCCACCCTCCCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18922232675739131					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369831	59369881	58904159	58904209	14720	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-37				GCCGGAGGATGGGCCCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.46362551502903					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369198	59369248	58903526	58903576	14721	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-38				CCATACATTGAGCATTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33809512658737328					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369418	59369468	58903746	58903796	14722	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-39				CCGCGGGAGGAGCGGGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9086899232774464					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369304	59369354	58903632	58903682	14723	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-4				AACTCCGACGTTGGTGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39553790257357241					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369368	59369418	58903696	58903746	14724	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-40				GCCACGTCCCGCCCGCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.041593623684572117					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369745	59369795	58904073	58904123	14725	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-41				TGACCCTGCTGGCCCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70869018737262157					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369590	59369640	58903918	58903968	14726	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-42				CGCAAAGGCGGGCAGGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7117152274722827					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369846	59369896	58904174	58904224	14727	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-43				AAGGGGCTGGCCGAGGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75351758314779649					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369911	59369961	58904239	58904289	14728	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-44				AGGAAAACAAACATTCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23302514600897281					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369862	59369912	58904190	58904240	14729	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-45				GCCCCTTCCCTCCCTCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17368308369164021					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369702	59369752	58904030	58904080	14730	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-46				CCGCGGCCTCCCGGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3475689173664796					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369346	59369396	58903674	58903724	14731	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-47				GCGGGGCAGGGCCGGGACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.697589386566797					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369147	59369197	58903475	58903525	14732	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-5				TCGTTGTGGTTACGCTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29992135282341642					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369895	59369945	58904223	58904273	14733	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-6				TAAGAGGTCTGCTAGGCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0057296188141409					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369517	59369567	58903845	58903895	14734	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-7				AGTCCTCGTGGGATCCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.014872766754449851					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369443	59369493	58903771	58903821	14735	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-8				GCGTGCGCTGACGTGGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0230637909085778					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59369874	59369924	58904202	58904252	14736	hg38	N/A	enh11917	N/A	Enhatls6781	enhancer	JUNe+7-9				GGAACGCGAACGCCAAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38378680375484042					JUN	chr1	58780790	58784047	115662				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448365	59448415	58982693	58982743	14737	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-1				CACGTCTGCTGTTTCACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14972240816168289					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448234	59448284	58982562	58982612	14738	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-10				GCTAAGTCTTAAAGAACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.231740794345089					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448463	59448513	58982791	58982841	14739	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-11				CTCTGGGCAGGAACACAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15618416061747381					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448245	59448295	58982573	58982623	14740	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-12				AAGAACAGAAGGCTTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73245555837620679					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448619	59448669	58982947	58982997	14741	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-13				CTCTGAGGAAATGCCTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15063575871290741					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448544	59448594	58982872	58982922	14742	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-14				TCTCTCCCTCTGCGCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43967023508226011					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448258	59448308	58982586	58982636	14743	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-15				TTTCTGCTGGGTAACAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82800820471889991					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448509	59448559	58982837	58982887	14744	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-16				TGTCCAGCTGAGGCCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4818957255072876					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448393	59448443	58982721	58982771	14745	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-17				TGTGGTTGTTTTTAGTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42002321267264747					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448604	59448654	58982932	58982982	14746	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-18				CCTCTGGACTTGGGTCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048522324038269761					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448570	59448620	58982898	58982948	14747	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-19				ACAGGAAAATGGCTGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26544703755377042					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448480	59448530	58982808	58982858	14748	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-2				TAATCCTGTTTACTCGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4263446761268373					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448349	59448399	58982677	58982727	14749	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-20				AGCAACAGGGGTGAGGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.632993019465844					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448530	59448580	58982858	58982908	14750	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-21				CACACTGGCTGCAGCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51368075028130544					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448209	59448259	58982537	58982587	14751	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-22				AAGTGTCACCTCTTCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29255210671422771					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448559	59448609	58982887	58982937	14752	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-23				GGGAGAGAGTGACAGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23976043082261661					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448195	59448245	58982523	58982573	14753	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-3				TCGTAGATGAACAGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44773831325101088					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448333	59448383	58982661	58982711	14754	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-4				TGTTGCTTGACCCTGTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37561158477085571					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448588	59448638	58982916	58982966	14755	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-5				TTAGGAACCGCCCTTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1208565325535013					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448437	59448487	58982765	58982815	14756	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-6				TTCTCTCTCCAGGGGATATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51711789723804114					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448496	59448546	58982824	58982874	14757	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-7				AGGATTATTGGAACCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45033261091357918					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448279	59448329	58982607	58982657	14758	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-8				GGGAAGGCCATGATTGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1452046918775286					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59448322	59448372	58982650	58982700	14759	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+8-9				TGTAAACACAGCCAGGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1529262080879861					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453007	59453057	58987335	58987385	14760	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-1				ATACCTGGTGCAATTGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1843328301789709					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452877	59452927	58987205	58987255	14761	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-10				AGCCCATGGGAAGCCTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27314671252217149					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452937	59452987	58987265	58987315	14762	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-11				TAGGATCACAGCAAGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10181741510707459					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452811	59452861	58987139	58987189	14763	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-12				CTCTGACTTTCAAGATTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.011919826153852949					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453087	59453137	58987415	58987465	14764	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-13				TGGTCACAGTGTGACATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13119726710841939					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453234	59453284	58987562	58987612	14765	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-14				TGGCAGGAAGACGGCCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25543172358305161					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452862	59452912	58987190	58987240	14766	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-15				TTAGCAGGAGATCAGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020950592573944559					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452825	59452875	58987153	58987203	14767	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-16				AAGTCAGAGAGAGGAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28321047654785					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452992	59453042	58987320	58987370	14768	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-17				ACAAATATTCATCAAATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.401996504232457					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452891	59452941	58987219	58987269	14769	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-18				TTTCAGTTGGGTTCAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47780607257637442					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452707	59452757	58987035	58987085	14770	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-19				GCTCAGATTTCCAGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0511986191920865					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453210	59453260	58987538	58987588	14771	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-2				GAGGGGTTACTCACTCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69722142799174491					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452686	59452736	58987014	58987064	14772	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-20				GCTCAAGATGTTGACAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13343373718736259					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452767	59452817	58987095	58987145	14773	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-21				CTGCCATAACAAAATATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01022453125504527					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452724	59452774	58987052	58987102	14774	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-22				AATTTATTTTCTCACAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39480183214178888					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453018	59453068	58987346	58987396	14775	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-3				AATTGTACCAGGAGCTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46195290827376939					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452918	59452968	58987246	58987296	14776	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-4				GATAAGGGTACAATTAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74130763938257438					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452904	59452954	58987232	58987282	14777	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-5				ACCCTTATCTGGTTTTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34633017897708751					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453067	59453117	58987395	58987445	14778	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-6				ATAGAGTCCCTTGTCTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23860329293619811					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59452791	59452841	58987119	58987169	14779	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-7				AGGGAATGTGTTCGTTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30095496602184407					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453142	59453192	58987470	58987520	14780	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-8				GTAATCTACATTGTACAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00060757120481454044					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-6228	chr1	59453188	59453238	58987516	58987566	14781	hg38	N/A	enh47181	N/A	Enhatls6781	enhancer	JUNe+9-9				ATGATGCTATGACTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38512815231500219					JUN	chr1	58780790	58784047	178487				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	6227
enhrx-16084	chr1	226416472	226416522	226228771	226228821	14782	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-1				TAGCTATTAACACTGTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1848401576966					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416306	226416356	226228605	226228655	14783	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-10				GAGTGCAGTGGCACGCTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.971412277276694					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415844	226415894	226228143	226228193	14784	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-11				AGACTGGTCTCAAACTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5758548395583656					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416128	226416178	226228427	226228477	14785	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-12				GGTTGCACTGAGCCGAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6929693046116232					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416274	226416324	226228573	226228623	14786	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-13				TGCTTGAGTTCAGGAGTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0091274660232961					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416249	226416299	226228548	226228598	14787	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-14				AATCGTGAGGCTGATGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7768129128491039					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416318	226416368	226228617	226228667	14788	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-15				GTCACTCAGGCTGAGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.02053378517691					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416236	226416286	226228535	226228585	14789	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-16				TGTGGTCCCAGCTAATCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3052443092165542					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416205	226416255	226228504	226228554	14790	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-17				AAAAAAAAAGTCAGGCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48030250340324709					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415904	226415954	226228203	226228253	14791	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-18				AAAAAAAAAGCCAGGCACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62923868618846923					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415860	226415910	226228159	226228209	14792	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-19				TCTTGCTATGTTGTCCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4398559314770214					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416403	226416453	226228702	226228752	14793	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-2				ATAAGTACACTTTGCTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01270479562944043					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416165	226416215	226228464	226228514	14794	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-20				ACAGAGTCTCACTGTCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3556425490940729					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416147	226416197	226228446	226228496	14795	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-21				TGGGCCACTGCACTCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9216409117199871					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416218	226416268	226228517	226228567	14796	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-22				GGCATGGTGGCATGTGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22614346965491389					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416101	226416151	226228400	226228450	14797	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-23				GAGAATTGCTTGAACTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1173132390836518					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415934	226415984	226228233	226228283	14798	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-24				TGTAATCCCAGGACTTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.677505955697256					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416331	226416381	226228630	226228680	14799	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-25				AAGGTCTCACTCTGTCACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5685726106784079					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415884	226415934	226228183	226228233	14800	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-26				TTTTTTTTTTTTCAAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3863125977359989					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416075	226416125	226228374	226228424	14801	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-27				CCCAGCTACTCAGGAGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94260507581602881					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415958	226416008	226228257	226228307	14802	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-28				TAAGGCAGGCAGATCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3400420480243023					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416018	226416068	226228317	226228367	14803	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-29				TTGTATTTTTAGTAGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8932598662464328					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416501	226416551	226228800	226228850	14804	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-3				GAGACCTCCTGAGCACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5735970698374526					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416004	226416054	226228303	226228353	14805	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-30				GAGAGAGGGTTTCACCATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.43764597718063					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416042	226416092	226228341	226228391	14806	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-31				AATTAGCTGGGCATGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.567881007815231					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415981	226416031	226228280	226228330	14807	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-32				TCAGGAGTTCAAGACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1789234403793539					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416030	226416080	226228329	226228379	14808	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-33				TAAAAATACAAAAATTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85045844137511328					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416383	226416433	226228682	226228732	14809	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-4				AGGCCTCAACTATGTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7223805459874981					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416366	226416416	226228665	226228715	14810	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-5				TCTTGGCTGCTTTTTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18120631592216241					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416450	226416500	226228749	226228799	14811	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-6				AATGTTTATCAGCTCATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50991754040452852					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416486	226416536	226228785	226228835	14812	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-7				GTGCTCAGGGCCCATCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.514047759572188					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226415923	226415973	226228222	226228272	14813	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-8				GTGGCTCACGCTGTAATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.56100765737485					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16084	chr1	226416350	226416400	226228649	226228699	14814	hg38	N/A	N/A	N/A	Enhatls17657	enhancer	MIXL1e-1-9				CTGGGGGAATGGCAGGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5290264439913641					MIXL1	chr1	226223617	226227060	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16083
enhrx-16181	chr1	227544467	227544517	227356766	227356816	14815	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-1				CTGCCCTATTGGCTGGCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20375140647098119					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544422	227544472	227356721	227356771	14816	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-10				AGTGGCTGTGCAAACCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66803220836622512					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544440	227544490	227356739	227356789	14817	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-11				GTTCAGCCACTGTCACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27884009772477519					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544520	227544570	227356819	227356869	14818	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-12				CAGCTGAGGTAAGCTGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50968283939348					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544404	227544454	227356703	227356753	14819	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-13				GCAGGGAGTTTCATTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53366792069834634					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544258	227544308	227356557	227356607	14820	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-14				AGGGAGTAGAAGAGTAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.385972600166772					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544238	227544288	227356537	227356587	14821	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-15				GATCCAGAAGAATAGGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2067407229142755					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544563	227544613	227356862	227356912	14822	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-16				TGGTGAAGTTCTTAGTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14895191169290489					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544506	227544556	227356805	227356855	14823	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-17				AGAAAAATGTGATACAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2285064166579634					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544276	227544326	227356575	227356625	14824	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-18				ACAGGAGAGAAAGCAATCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74736986332571753					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544211	227544261	227356510	227356560	14825	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-19				GTATGCAAGTAATTTATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73876852474246046					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544345	227544395	227356644	227356694	14826	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-2				TGACCATAGAGCGTTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45673523405536293					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544330	227544380	227356629	227356679	14827	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-20				AACTGGGGCTCCATCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37959568008286287					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544314	227544364	227356613	227356663	14828	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-3				GGCCATTATCATGTGCAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12765664988502981					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544388	227544438	227356687	227356737	14829	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-4				CACTGGTCAAGCGTTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0058083408222218526					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544300	227544350	227356599	227356649	14830	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-5				ATAATGGCCAGCTTAATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.363885892817036					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544371	227544421	227356670	227356720	14831	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-6				AAATTGTGACCATCTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050928893123669612					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544478	227544528	227356777	227356827	14832	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-7				GATCTCACTTCCTGCCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.202671814282971					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544196	227544246	227356495	227356545	14833	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-8				TTGCATACAAACCCTTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47960590710543283					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544548	227544598	227356847	227356897	14834	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-10-9				CTTCACCAGCAATGAAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1898275718860756					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545291	227545341	227357590	227357640	14835	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-1				TGTCGGAAGTGTTGGCCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13307104644548989					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545336	227545386	227357635	227357685	14836	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-10				ACTGCCCAGAACTTCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20594921739299851					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544996	227545046	227357295	227357345	14837	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-11				GAGACAGATTTGCCTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0026292407743060651					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545190	227545240	227357489	227357539	14838	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-12				ATACTGCCTCCCTCAGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24779460313437451					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545249	227545299	227357548	227357598	14839	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-13				GAGGGACTGAGAACATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059979971379231112					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545276	227545326	227357575	227357625	14840	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-14				TGACTCAGCTGAAAGCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42027258570163462					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545049	227545099	227357348	227357398	14841	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-15				TAATGGGCATGGAAGGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2058160825569767					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545213	227545263	227357512	227357562	14842	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-16				CTGGAGACTGACCCCAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092105553570971915					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545087	227545137	227357386	227357436	14843	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-17				GAGCTGAACTGGGGAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19867812815189981					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545112	227545162	227357411	227357461	14844	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-18				CAAAGCCAGGCTGCAGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24216810954818879					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545076	227545126	227357375	227357425	14845	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-19				AAAAGAGGGAAGAGCTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054262332538996851					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545378	227545428	227357677	227357727	14846	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-2				ATCCAAGCAGCGGAAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51384155267097942					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545099	227545149	227357398	227357448	14847	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-20				GGAGCAGCTGGAACAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29374539575660619					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545062	227545112	227357361	227357411	14848	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-21				AGGAGATAGGATTGAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94278692324967461					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227544981	227545031	227357280	227357330	14849	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-22				TCTGTCTCAGAGTCTGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047997124521715187					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545231	227545281	227357530	227357580	14850	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-3				CAGGGAATGTCCTTGGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52321400695450448					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545146	227545196	227357445	227357495	14851	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-4				TAGCCCATCTTGTCCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53884427487839082					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545032	227545082	227357331	227357381	14852	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-5				GTCTTATGAGTCAGCACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040948415895241112					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545304	227545354	227357603	227357653	14853	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-6				ACTTCCGACAGCTGGGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32704522957208321					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545159	227545209	227357458	227357508	14854	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-7				ATCCCCCTTTGCACCAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0505460810181249					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545008	227545058	227357307	227357357	14855	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-8				CACCCCAGTAAACCTCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081858761330011173					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16181	chr1	227545322	227545372	227357621	227357671	14856	hg38	N/A	enh12732	N/A	Enhatls17769	enhancer	MIXL1e-11-9				AATGGTATCTCAGTCCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31417708499455188					CDC42BPA	chr1	226989864	227318492	35493				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16180
enhrx-16208	chr1	228273099	228273149	228085398	228085448	14857	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-1				TGTCTGTCAAGTCGCTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1178657651062488					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273270	228273320	228085569	228085619	14858	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-10				TGGTAACAAGGGCTTGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36078588590460181					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273173	228273223	228085472	228085522	14859	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-11				CCTGTCACTCAGCCACCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.334620427128395					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273335	228273385	228085634	228085684	14860	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-12				TTTAGGCTTCTCCTGTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64524501816493773					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273128	228273178	228085427	228085477	14861	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-13				GGATGCTCTTTGTTCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034320837117905477					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273143	228273193	228085442	228085492	14862	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-14				GGGAGGACCTGAGAGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39726302661197888					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273386	228273436	228085685	228085735	14863	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-15				AAAGGCAGGCAGATTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96758742089132688					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273185	228273235	228085484	228085534	14864	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-16				TGTCTCCCCATCCCTGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.027956415315467					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273160	228273210	228085459	228085509	14865	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-17				GAGTGACAGGACCCTGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.027465578090297					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273246	228273296	228085545	228085595	14866	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-18				TGTGTGAGAACCAGGAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38719074885041349					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273352	228273402	228085651	228085701	14867	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-19				TGTCTCTTCTCTTGTCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86482441087954387					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273051	228273101	228085350	228085400	14868	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-2				AACTACCTATCTGGACGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1708872090371061					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273372	228273422	228085671	228085721	14869	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-20				ACAGGGAAAGCATAAAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43529631263271812					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273032	228273082	228085331	228085381	14870	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-3				GCGGCAGCTGCGCAGCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45481367794534672					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273290	228273340	228085589	228085639	14871	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-4				CGGTTGTCAGCCAACAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1559700873996018					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273311	228273361	228085610	228085660	14872	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-5				GGAAGGGTGGTGCTTCTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90299440511963935					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273226	228273276	228085525	228085575	14873	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-6				AGGATTAGTCAAGGACTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2213664516707059					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273324	228273374	228085623	228085673	14874	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-7				TTCTTACAGGCCCTGATAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51620751691632027					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273258	228273308	228085557	228085607	14875	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-8				GTTCTCACACAGTGGTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29863832879671282					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16208	chr1	228273064	228273114	228085363	228085413	14876	hg38	N/A	enh89543	N/A	Enhatls17797	enhancer	MIXL1e-12-9				ATAGGTAGTTTCACATTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.17883357186418					ARF1	chr1	228082707	228099212	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16207
enhrx-16097	chr1	226521100	226521150	226333399	226333449	14877	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-1				TACAAGACTGGTGCCACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17457179082956861					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521393	226521443	226333692	226333742	14878	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-10				ATGTGATACACTCCTGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.023014907086165281					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521088	226521138	226333387	226333437	14879	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-11				CTCACAATTAACTACAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.105368088573832					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521073	226521123	226333372	226333422	14880	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-12				ATTGTGAGAATACATTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25868637979479092					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521191	226521241	226333490	226333540	14881	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-13				AAAAACGTAGATGACTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.955192963451662					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521168	226521218	226333467	226333517	14882	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-14				ACCGAGAGAAAGAAGTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32384996055923049					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521226	226521276	226333525	226333575	14883	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-15				CGAGTCATTGCCACCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6621857418212489					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521257	226521307	226333556	226333606	14884	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-16				GTCTTTGAAGGCAGTGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.031530344212627653					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521381	226521431	226333680	226333730	14885	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-2				CACGCTTGGGCTCCTGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22344048009886289					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521344	226521394	226333643	226333693	14886	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-3				GTCGTGGGAGATGAATGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40134850502713981					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521203	226521253	226333502	226333552	14887	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-4				TCTACGTTTTTCAGCTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18845929497937031					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521245	226521295	226333544	226333594	14888	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-5				CAGGATGCTTCCGTCTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.151621522683642					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521113	226521163	226333412	226333462	14889	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-6				CTCAGCTCGTTTCCCAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.369552755822941					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521302	226521352	226333601	226333651	14890	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-7				GCCGCTTCTCAGCCTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33234978676333871					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521290	226521340	226333589	226333639	14891	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-8				TAAATATGAGCGCCACCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21087080742554709					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16097	chr1	226521366	226521416	226333665	226333715	14892	hg38	N/A	enh963	N/A	Enhatls17672	enhancer	MIXL1e-2-9				CAAGCGTGCATGTGGACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29490793029738338					LIN9	chr1	226231148	226309869	15996				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16096
enhrx-16112	chr1	226593382	226593432	226405681	226405731	14893	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-1				AGGCTAGAACAACACCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1170822568182109					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592895	226592945	226405194	226405244	14894	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-10				TATGTAATGGTGATTAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72172946380485081					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592620	226592670	226404919	226404969	14895	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-11				GGGAGGGTTTGAGCACCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11067463725359671					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593354	226593404	226405653	226405703	14896	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-12				GTTAGAGGAGGCTTAGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86047372490063856					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592521	226592571	226404820	226404870	14897	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-13				CCAACCAGCAGCTGGTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25536597671162542					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592711	226592761	226405010	226405060	14898	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-14				CATGCCTGGGGCATCTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8701762856246158					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592588	226592638	226404887	226404937	14899	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-15				AGGTCAGTTCATTCTCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10941510477676469					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592953	226593003	226405252	226405302	14900	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-16				TTCACTATCAAGTATACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.419847892676849					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592508	226592558	226404807	226404857	14901	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-17				TGCTGGTTGGGTGAGGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.166897324056516					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592565	226592615	226404864	226404914	14902	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-18				GCCATGCTACCTGTCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51654163779780149					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592700	226592750	226404999	226405049	14903	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-19				CATCTTGGGAGGGATGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047599616321280173					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593369	226593419	226405668	226405718	14904	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-2				ACCGCTGTGGAGGAAGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.241098835184786					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593430	226593480	226405729	226405779	14905	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-20				TTTGTCTTTCCACCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057747147012432831					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592858	226592908	226405157	226405207	14906	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-21				TTCAGAATTTAAAGTTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42105968476721					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592543	226592593	226404842	226404892	14907	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-22				GGTTCCCTTCTGTGCAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41237731591988158					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592969	226593019	226405268	226405318	14908	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-23				CAACATTCTGGGCTTTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60496452898116126					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592775	226592825	226405074	226405124	14909	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-24				TCCCATGTAAATGTAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.421537025648562					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593341	226593391	226405640	226405690	14910	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-25				TAGCTGTGGGGGAGGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0435980399805343					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593160	226593210	226405459	226405509	14911	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-26				ATGCAATGATTAGCGGGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.058570145037402169					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592801	226592851	226405100	226405150	14912	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-27				TTAAATTCAAGCAAGTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18713096322554229					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592801	226592851	226405100	226405150	14913	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-27				TTAAATTCAAGCAAGTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18713096322554229					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592981	226593031	226405280	226405330	14914	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-28				AAATAGTAATAACAACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.61272963201734					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593009	226593059	226405308	226405358	14915	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-29				TTCAGACAGGGTCTGGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.682639363090998					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593395	226593445	226405694	226405744	14916	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-3				GTTCTAGCCTCAACACAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32006299669708471					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592816	226592866	226405115	226405165	14917	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-30				TGAAAAGGCTTCTTTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76411965917480829					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592816	226592866	226405115	226405165	14918	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-30				TGAAAAGGCTTCTTTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76411965917480829					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592908	226592958	226405207	226405257	14919	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-31				TAACTGTGATTTTTATGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8937174041664897					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592670	226592720	226404969	226405019	14920	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-32				GCATTTTGGTGGGAGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.10632707911642					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592670	226592720	226404969	226405019	14921	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-32				GCATTTTGGTGGGAGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.10632707911642					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593326	226593376	226405625	226405675	14922	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-33				CAGGTTCAGTTTCCTCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97132924295955281					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593128	226593178	226405427	226405477	14923	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-34				CGGAGTAGCTGGGACTTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16988375335194941					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593108	226593158	226405407	226405457	14924	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-35				AATCTTCCAGCTTCAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43848959790414349					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592996	226593046	226405295	226405345	14925	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-36				TACTATTTTTTTTTTCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.662579270455266					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593028	226593078	226405327	226405377	14926	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-37				TGGGTCTGGGTCTGTCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64294162149659184					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593191	226593241	226405490	226405540	14927	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-38				AGAGACAGGTTTCACCATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82377685944460655					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593092	226593142	226405391	226405441	14928	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-39				GAAGATTGCTTGAGCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3281928445009821					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593301	226593351	226405600	226405650	14929	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-4				CAAGTTTAGCATTCTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1174119246226534					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593257	226593307	226405556	226405606	14930	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-40				ATCTCAGCACTTTGGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2005095309332145					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593046	226593096	226405345	226405395	14931	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-41				AGTGCCACTGCACTCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.195783787902779					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593177	226593227	226405476	226405526	14932	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-42				TTGCATTTTTTTGTAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056575645043866349					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593282	226593332	226405581	226405631	14933	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-43				CAAGCATGCGCCACCAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40448652778881611					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593214	226593264	226405513	226405563	14934	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-44				TCAGCAGTTTGAGACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32545511834035118					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226593078	226593128	226405377	226405427	14935	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-45				CACTGCAACCTCCACCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0950837182023019					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592681	226592731	226404980	226405030	14936	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-5				TGGGCCCTCCAGCATTTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.080714490372355743					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592681	226592731	226404980	226405030	14937	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-5				TGGGCCCTCCAGCATTTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.080714490372355743					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592845	226592895	226405144	226405194	14938	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-6				GTTGGTCTGGTAGACTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67057976476012					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592608	226592658	226404907	226404957	14939	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-7				GCACCCGGAGGCATGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24909613855285029					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592641	226592691	226404940	226404990	14940	hg38	N/A	enh966	N/A	Enhatls17692	enhancer	MIXL1e-3-8				ACCTTTGAGTTGCTCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26777897155552272					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592641	226592691	226404940	226404990	14941	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-8				ACCTTTGAGTTGCTCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26777897155552272					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16112	chr1	226592725	226592775	226405024	226405074	14942	hg38	N/A	enh966	fant5051	Enhatls17692	enhancer	MIXL1e-3-9				GACACTTTAGCCCTCATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21759207658045571					PARP1	chr1	226360690	226408100	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16111
enhrx-16113	chr1	226601832	226601882	226414131	226414181	14943	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-1				GAGCTCACTGCGTTTATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26610891117586721					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601666	226601716	226413965	226414015	14944	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-10				ACGTGACCCTCTTCAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22233921995424161					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601957	226602007	226414256	226414306	14945	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-11				AAAGTCACCAGACGTAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39616979855341578					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601683	226601733	226413982	226414032	14946	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-12				TCACGTGTTATTTCCCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035349973394079651					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601701	226601751	226414000	226414050	14947	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-13				GCATGGAAGAGAGCACAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00060757120481454044					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601727	226601777	226414026	226414076	14948	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-14				ATGCGATAAGGGGATAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1034324762095356					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602128	226602178	226414427	226414477	14949	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-15				GGTCCTGGCATCTGTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1544551550824515					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602235	226602285	226414534	226414584	14950	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-16				ACACAGGATTAGGTGCATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51779624086973752					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602293	226602343	226414592	226414642	14951	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-17				ACAGGCCTCACAATCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7503711842471068					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602021	226602071	226414320	226414370	14952	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-18				GGGTGCCAGTGGGTTGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65806790078553379					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601999	226602049	226414298	226414348	14953	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-19				TGGGTGTGTGCCCCTGCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.154939643174101					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601816	226601866	226414115	226414165	14954	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-2				TGAGCTCGGATTCAGTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15688123939750451					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602048	226602098	226414347	226414397	14955	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-20				GGGAGTTCCATCTTCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34542943785855412					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602184	226602234	226414483	226414533	14956	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-21				CTCGCTCCTGGCTCGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21031077112579019					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602062	226602112	226414361	226414411	14957	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-22				CAGGCTGCTACCAACCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13401331989296181					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601853	226601903	226414152	226414202	14958	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-23				GGTGTCTTTCACAGTGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16536050241505021					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601945	226601995	226414244	226414294	14959	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-24				CGTAGCTGTGGAAAGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067622184847819164					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601628	226601678	226413927	226413977	14960	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-25				GGAGAATCTTTGGGACAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26475728816279392					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602252	226602302	226414551	226414601	14961	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-26				CTGTGTGCTGTCCATCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.098074136971678577					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602195	226602245	226414494	226414544	14962	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-27				CTCGGCAGCAGGCCCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.91369083159477571					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601767	226601817	226414066	226414116	14963	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-28				TCCTATTTGAAAATGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37256084291426					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602152	226602202	226414451	226414501	14964	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-29				TGCAAACCCAGGCAAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35131973231237468					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602279	226602329	226414578	226414628	14965	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-3				CTGCAGTGGACCTATATATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36526115858399483					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602099	226602149	226414398	226414448	14966	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-30				CACAGCCAGTGTGGGGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1640639940663					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602010	226602060	226414309	226414359	14967	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-31				CCCTGCGATGGGGGTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0798000699755881					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602081	226602131	226414380	226414430	14968	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-32				GAGGGAGGCTCTGTGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74685754604523746					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601652	226601702	226413951	226414001	14969	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-33				AGAAGTGGGAGGAAGTGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9041742525011871					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601970	226602020	226414269	226414319	14970	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-34				TGGTGACTTTGTGTGTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34275819830162818					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602267	226602317	226414566	226414616	14971	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-4				TATATATCAGGAAGCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22836769720772571					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601739	226601789	226414038	226414088	14972	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-5				ATAAATCGTGTCATGCGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092459716130441863					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601871	226601921	226414170	226414220	14973	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-6				GACGGTCTTCAACAATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24125576819259961					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226601803	226601853	226414102	226414152	14974	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-7				AGTGTTACGGTGACTGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40362787287634361					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602172	226602222	226414471	226414521	14975	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-8				GCAGTTTCCTTACTCGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19951538189501211					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226602209	226602259	226414508	226414558	14976	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-4-9				CTCCCAGATAGCAGCCGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74893608470759865					PARP1	chr1	226360690	226408100	5000				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617175	226617225	226429474	226429524	14977	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-1				TGCTGTTAGCCTATTAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23049845019183851					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617147	226617197	226429446	226429496	14978	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-10				GCACAGTCACTTCTCCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045058366222508341					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617059	226617109	226429358	226429408	14979	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-11				GGGATGAATGACACATGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27042790354606561					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616816	226616866	226429115	226429165	14980	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-12				AACGCTTTAATTTATTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2345053752701492					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616773	226616823	226429072	226429122	14981	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-13				AACTGCTGTGTGAATTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016141734500430709					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616798	226616848	226429097	226429147	14982	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-14				AGAGCTGTAAAGACATCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57008407944141137					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616977	226617027	226429276	226429326	14983	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-15				GAGTGCAGGAAGTGTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.015009959933989609					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616939	226616989	226429238	226429288	14984	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-16				GTCTCACTGAGAGAAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090095962063657276					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617016	226617066	226429315	226429365	14985	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-17				CAAGGGAGGGAGGACCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.712097476176961					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616857	226616907	226429156	226429206	14986	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-18				GGCTCAGCGTCTCTCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.015019911908103889					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616840	226616890	226429139	226429189	14987	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-19				AATCATTCAGCCAAGAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89709283017610686					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617161	226617211	226429460	226429510	14988	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-2				CTAACAGCACATTGCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1406174004830244					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616952	226617002	226429251	226429301	14989	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-20				AAGCCACAGGGGTCGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.172147872528313					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617072	226617122	226429371	226429421	14990	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-21				CATGTCTGGGACAGGGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74005781742465415					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616722	226616772	226429021	226429071	14991	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-22				TGAGAGGGCTCTGGGATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.808054310059179					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616891	226616941	226429190	226429240	14992	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-23				GGGAGCTGGGGAGAGAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47581422387851618					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616963	226617013	226429262	226429312	14993	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-24				GTCGGGGGAGGGAGGAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6208112529654051					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616905	226616955	226429204	226429254	14994	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-25				GAGCGTGGGGGAAGGGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4064332908307891					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616738	226616788	226429037	226429087	14995	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-3				GTGTATAATTCAGTGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1067218473637755					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617110	226617160	226429409	226429459	14996	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-4				GCCGGTGTGCCCACTGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32004143850896871					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617001	226617051	226429300	226429350	14997	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-5				ACATGTCACAGCGAGCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49863018382611818					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617038	226617088	226429337	226429387	14998	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-6				GAGTCACCTCTTTGGTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16408841757317161					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617125	226617175	226429424	226429474	14999	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-7				GCTTGGGGGATGGACTAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02001531769941					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226617095	226617145	226429394	226429444	15000	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-8				ACACCGGCGGCTGCCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46043849698937123					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226616870	226616920	226429169	226429219	15001	hg38	N/A	enh967	N/A	Enhatls17693	enhancer	MIXL1e-5-9				ACGCTGAGCCCCTAGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3402330748370076					PARP1	chr1	226360690	226408100	14505				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708514	226708564	226520813	226520863	15002	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-1				ACTTGTTCCTGTGAGCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25382646959545091					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708417	226708467	226520716	226520766	15003	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-10				GGCAACAGTGATTAAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.607406083245856					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708388	226708438	226520687	226520737	15004	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-11				CAGGTGCTGGATCAGGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59601637130625829					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708525	226708575	226520824	226520874	15005	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-12				TGAGCTAGGAGGAGCTCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1150640432127859					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708611	226708661	226520910	226520960	15006	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-13				TGCATTCTAAAATCCTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035854445456332713					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708596	226708646	226520895	226520945	15007	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-14				AGAATGCAGAGAGCAGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39838773645873238					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708291	226708341	226520590	226520640	15008	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-15				TAAATCATTATAAACCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13242175837166209					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708346	226708396	226520645	226520695	15009	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-16				GACAGATCCTGACCCAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85660574722696614					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708401	226708451	226520700	226520750	15010	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-17				CCAGCACCTGCAACCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4417896446712361					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708370	226708420	226520669	226520719	15011	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-18				ACAGGGAAAGGAAGATGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47481067345177369					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708478	226708528	226520777	226520827	15012	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-2				TCATAGCGGAGGCTGGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35401480637338217					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708624	226708674	226520923	226520973	15013	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-3				TGCGTTTCATCTCCCAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13949741459115389					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708333	226708383	226520632	226520682	15014	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-4				AACTCGACTGCATCCTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.235503469803798					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708666	226708716	226520965	226521015	15015	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-5				CCTTTACAGTGCGGTTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0063934194797387956					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708467	226708517	226520766	226520816	15016	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-6				AAGGCAAAGGCTCATAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42659281640481428					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708279	226708329	226520578	226520628	15017	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-7				AACCCATGTGGCAAGTACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64351227307517656					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708448	226708498	226520747	226520797	15018	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-8				AAGAATAGATCAAGGGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40948948496236182					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226708558	226708608	226520857	226520907	15019	hg38	N/A	N/A	N/A	Enhatls17693	enhancer	MIXL1e-6-9				ATGCCAGCTGAGCAGCATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32861748991376338					STUM	chr1	226548763	226609230	25160				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720324	226720374	226532623	226532673	15020	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-1				ATGAGGCCAGCGGATATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0829690469596958					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720281	226720331	226532580	226532630	15021	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-10				GAAACTTTACTCTAAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4382154161724552					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720495	226720545	226532794	226532844	15022	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-11				GGCTACAGAGTCACAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.04199610668023869					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720308	226720358	226532607	226532657	15023	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-12				GCCTCATCTAACTACAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1430165981349221					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720564	226720614	226532863	226532913	15024	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-13				CTTTACTGACCTAAAATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2708917671527651					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720595	226720645	226532894	226532944	15025	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-14				ACAAGATAATGATTGTTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3296135679640973					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720401	226720451	226532700	226532750	15026	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-15				CCTTCCCTCTTCCCACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17215438389488319					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720529	226720579	226532828	226532878	15027	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-2				ATAGGCAGTCCTAATGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53478311007145662					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720454	226720504	226532753	226532803	15028	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-3				TCTGACATTCCTAGGATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80577569943036953					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720346	226720396	226532645	226532695	15029	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-4				GAAGAGATCTATGCAGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54052404342477711					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720362	226720412	226532661	226532711	15030	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-5				GTCTAGGGGATGCGTTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57714823831420681					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720412	226720462	226532711	226532761	15031	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-6				CAAGTGGTGCACCAGCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19286729245755					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720511	226720561	226532810	226532860	15032	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-7				TGTAGCCACCACAAGAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11540133018237					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720478	226720528	226532777	226532827	15033	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-8				TGTCTAGATAAAAGGATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28049289605272282					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16113	chr1	226720428	226720478	226532727	226532777	15034	hg38	N/A	enh50229	N/A	Enhatls17693	enhancer	MIXL1e-7-9				GGCTGTCTGCATGGCTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17092612653223269					STUM	chr1	226548763	226609230	13210				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16112
enhrx-16115	chr1	226757794	226757844	226570093	226570143	15035	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-1				GAGCCCTGCAAACATCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47488981106258421					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757711	226757761	226570010	226570060	15036	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-10				ACAGGAGGAGCCCTGATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51585724231041752					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757609	226757659	226569908	226569958	15037	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-11				TCTGGAGCTGCTCTGCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31441262555055172					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757680	226757730	226569979	226570029	15038	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-12				CTGAGGGACCAGTGAGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32291397748576761					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757892	226757942	226570191	226570241	15039	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-13				CAGTCAGTGAGATTTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25679312237151308					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757781	226757831	226570080	226570130	15040	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-14				ATCCAGCAGGGGGCTTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.760043880396678					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757847	226757897	226570146	226570196	15041	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-15				AGGGCTGTCACCCGGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26114436528042362					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757816	226757866	226570115	226570165	15042	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-16				AGGAGGGCATCACTCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52429232971410444					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757734	226757784	226570033	226570083	15043	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-17				TCAGGTTGGGGGCTGAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.324838065929257					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757754	226757804	226570053	226570103	15044	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-18				TGAGCCCCGCCCCTCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77790854618874472					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757621	226757671	226569920	226569970	15045	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-19				CTGCAGTAAGGTGAGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32129290932386312					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757875	226757925	226570174	226570224	15046	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-2				TGACTGTTCTGCTTACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62979379835234439					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757696	226757746	226569995	226570045	15047	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-3				ATGTGTGGCAGTCACCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1450889540026373					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757827	226757877	226570126	226570176	15048	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-4				TGATGCCCTCCTTTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52246934971707837					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757859	226757909	226570158	226570208	15049	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-5				CGGAGCTCTGGTGGCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34128562677766783					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757657	226757707	226569956	226570006	15050	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-6				TAAAAAAGAGCCTCCAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24765583879769179					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757911	226757961	226570210	226570260	15051	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-7				GAGGTTCAAAATGTGGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.001821672851605243					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757768	226757818	226570067	226570117	15052	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-8				CTTGTGAAGGAGGGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.511269361338567					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16115	chr1	226757591	226757641	226569890	226569940	15053	hg38	N/A	enh43163	N/A	Enhatls17694	enhancer	MIXL1e-8-9				GGTTTGAAGCATTTTTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084109305162764492					STUM	chr1	226548763	226609230	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16114
enhrx-16123	chr1	226867731	226867781	226680030	226680080	15054	hg38	N/A	enh973	fant5070	N/A	enhancer	MIXL1e-9-1				TGGTTCCGTAAGCTGGTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24731133097952671					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867731	226867781	226680030	226680080	15055	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-1				TGGTTCCGTAAGCTGGTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24731133097952671					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867970	226868020	226680269	226680319	15056	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-10				GTCATGCTGATTTGGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0979303087604285					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867802	226867852	226680101	226680151	15057	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-11				TTGAGGCCATCTGAGGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074392774480118634					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868130	226868180	226680429	226680479	15058	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-12				GTCAGCTCTTTCCCCAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11980910873902829					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867786	226867836	226680085	226680135	15059	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-13				GAGCAGGGTCAACTCTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0053029710871072061					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868007	226868057	226680306	226680356	15060	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-14				CGAGTTCCTGAAATTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.134232351578285					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867770	226867820	226680069	226680119	15061	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-15				AACACATCACCTGTGAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43172636881680071					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868152	226868202	226680451	226680501	15062	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-16				GAGGCAATGCTGAATGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.014896483641054651					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868152	226868202	226680451	226680501	15063	hg38	N/A	enh973	N/A	Enhatls17705	enhancer	MIXL1e-9-16				GAGGCAATGCTGAATGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.014896483641054651					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868056	226868106	226680355	226680405	15064	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-17				GTCCCTTTTGGCAGAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48899227240111709					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867874	226867924	226680173	226680223	15065	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-18				GTCGCGGGCGCTGCGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6841810022037349					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867685	226867735	226679984	226680034	15066	hg38	N/A	enh973	fant5070	N/A	enhancer	MIXL1e-9-19				AGCAGCAGTAGGAAATCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12957122521318279					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867890	226867940	226680189	226680239	15067	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-2				GGTCCGTGCTCACGTGGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1145497660227887					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868093	226868143	226680392	226680442	15068	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-20				GAGGGCATCCCAGAACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1220584297496841					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867696	226867746	226679995	226680045	15069	hg38	N/A	enh973	fant5070	N/A	enhancer	MIXL1e-9-21				GCCAAAGTGTCAGCAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0135068139509887					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867860	226867910	226680159	226680209	15070	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-22				GCTGCCTGGAGGCTCAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10783147868279119					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868141	226868191	226680440	226680490	15071	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-23				CAGCATTGCCTCCTCTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20593426612625029					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868141	226868191	226680440	226680490	15072	hg38	N/A	enh973	N/A	Enhatls17705	enhancer	MIXL1e-9-23				CAGCATTGCCTCCTCTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20593426612625029					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868108	226868158	226680407	226680457	15073	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-24				CACATTTCTGTGCCTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2062312924824678					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867936	226867986	226680235	226680285	15074	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-25				GTGACTGCTGGGGCGGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28433217382519949					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868022	226868072	226680321	226680371	15075	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-26				AAGCTGTCTTTCAAACCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.105252876356434					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867911	226867961	226680210	226680260	15076	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-27				CATGGAAAGGCTGGGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28118844865653042					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868075	226868125	226680374	226680424	15077	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-28				GGGGAGGTAGGGAAGCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8714779469173275					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867925	226867975	226680224	226680274	15078	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-3				CTTTCCATGACGTGACTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.084426315137139454					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868169	226868219	226680468	226680518	15079	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-4				GTTAGGTAGGGTCCTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37149636906947					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868169	226868219	226680468	226680518	15080	hg38	N/A	enh973	N/A	Enhatls17705	enhancer	MIXL1e-9-4				GTTAGGTAGGGTCCTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37149636906947					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867994	226868044	226680293	226680343	15081	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-5				CAGGAACTCGCTTGCTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3292059552134376					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867718	226867768	226680017	226680067	15082	hg38	N/A	enh973	fant5070	N/A	enhancer	MIXL1e-9-6				TGGTCGGAGGCGCAGACGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32915910437490348					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226868044	226868094	226680343	226680393	15083	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-7				TAGAGATCCTAAGTCCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1990933352497754					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867755	226867805	226680054	226680104	15084	hg38	N/A	enh973	fant5070	N/A	enhancer	MIXL1e-9-8				GATGTGTTAGGATCGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2348987799210959					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867755	226867805	226680054	226680104	15085	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-8				GATGTGTTAGGATCGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2348987799210959					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16123	chr1	226867815	226867865	226680114	226680164	15086	hg38	N/A	enh973	fant5070	Enhatls17705	enhancer	MIXL1e-9-9				ATGGCCTCAAACTAAGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19710006198393429					ITPKB	chr1	226631689	226739323	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16122
enhrx-16082	chr1	226403034	226403084	226215333	226215383	15087	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-1				GGTTTAGGTAGGTCGTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6242050477380063					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403143	226403193	226215442	226215492	15088	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-10				GCTCAGTGTCTGGGGAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.8364527582619568					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403226	226403276	226215525	226215575	15089	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-11				TGGGGAATCCTCCCCAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.14307625825706					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403352	226403402	226215651	226215701	15090	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-12				CAAGGTCTTCTGGTCTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7285008804740229					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403078	226403128	226215377	226215427	15091	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-13				CTTTCTGGATGAAGGGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83728035842588278					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403194	226403244	226215493	226215543	15092	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-14				GAACTAGGGCTTGGTGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7316667340767369					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403292	226403342	226215591	226215641	15093	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-15				CAGTCCCTCCCTGTGGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70607117735848435					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403163	226403213	226215462	226215512	15094	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-16				AGCACAGCCAGGTGTTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1818498697119537					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402905	226402955	226215204	226215254	15095	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-17				CTACCCCCAGCACAGGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29542880837661661					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403126	226403176	226215425	226215475	15096	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-18				TATGGGCTTGGTGGAGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.4261381446140344					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403045	226403095	226215344	226215394	15097	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-19				AAAGGAGGCAGGGTTTAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1837617966199829					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402926	226402976	226215225	226215275	15098	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-2				AGAGTGCGGTCTTCCAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62790214592491045					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403214	226403264	226215513	226215563	15099	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-20				TGGCTTGTGCAGCCTGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7468429438397246					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403009	226403059	226215308	226215358	15100	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-21				TTGTTCACACCTCTGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2151162747138811					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402984	226403034	226215283	226215333	15101	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-22				GTACAAATGCAGAATGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94554841707808779					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402960	226403010	226215259	226215309	15102	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-23				CTGCAGAGAGCCAGCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4492379845524108					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403093	226403143	226215392	226215442	15103	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-24				AGTGTGGGGAGGAGGCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9347556725382269					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402874	226402924	226215173	226215223	15104	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-25				CATGGACCCTGAGGACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9950831990070759					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402892	226402942	226215191	226215241	15105	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-26				AGGCATCAGGCTGTGGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6412822433376109					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403274	226403324	226215573	226215623	15106	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-27				CACTGCACTCCTCCAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.2120366232839181					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402939	226402989	226215238	226215288	15107	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-28				GGCAGGCTGGGGCCCAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.974964095631504					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226402859	226402909	226215158	226215208	15108	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-3				GATCTTCCTCTGGGGCCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.072704733665387					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403246	226403296	226215545	226215595	15109	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-4				TGTGAGCATGACTTTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.92442413514058					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403313	226403363	226215612	226215662	15110	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-5				TGGGGCTGTCGAGTCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.708890851413762					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403329	226403379	226215628	226215678	15111	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-6				CTCTCGCTGTGTGAACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.27093821689208					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403180	226403230	226215479	226215529	15112	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-7				TGTGGGGTGTGTAGGAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0875513886964674					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403107	226403157	226215406	226215456	15113	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-8				TAGGGGCGGGTTTGAGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6608808714155789					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226403056	226403106	226215355	226215405	15114	hg38	N/A	enh957	N/A	Enhatls17655	enhancer	MIXL1e+1-9				GGCCGAGCCTGAAAGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0926125470345207					MIXL1	chr1	226223617	226227060	7226				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16065	chr1	226137064	226137114	225949364	225949414	15115	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-1				AGCTTAGCGTTGCATTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3317797366784162					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136823	226136873	225949123	225949173	15116	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-10				GGAGTCATTTGGGAATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.2626092406362579					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136842	226136892	225949142	225949192	15117	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-11				CGGGATAAGCCCTGTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.023586452373698049					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137025	226137075	225949325	225949375	15118	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-12				TAGGAGGTGTCAGGGCCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41367012574155881					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137081	226137131	225949381	225949431	15119	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-13				TAAGCTATCCCTTCAGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085043827188710439					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136467	226136517	225948767	225948817	15120	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-14				TGTGTCCCCAGGTGAAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4240454251598596					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136559	226136609	225948859	225948909	15121	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-15				TAGGATCACCCTGTTCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11263852718858169					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136857	226136907	225949157	225949207	15122	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-16				AGAAGAGGATCTACCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060588653093542492					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136655	226136705	225948955	225949005	15123	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-17				ACGGATCCTCTTCCCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07325412275753429					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136545	226136595	225948845	225948895	15124	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-18				GTGATCCTAAAGAAAGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39368509306223531					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136642	226136692	225948942	225948992	15125	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-19				GGGAGCGTTCTCACCAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2013610907321387					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136599	226136649	225948899	225948949	15126	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-2				GATCGTGTCTTCTAGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24899032506651311					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136726	226136776	225949026	225949076	15127	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-20				CCAGAGTGTGGCTGATAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36184020507478					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136478	226136528	225948778	225948828	15128	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-21				GTGGTTGAAGATGTGTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36135299164625267					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136912	226136962	225949212	225949262	15129	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-22				TTCCTCTCCACGACAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.09884913574361423					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137118	226137168	225949418	225949468	15130	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-23				TTGGAGCCCTGAGAGGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1033825953032342					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137104	226137154	225949404	225949454	15131	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-24				GGGCTCCAAAACCAAGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35323262173813968					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136880	226136930	225949180	225949230	15132	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-25				TTGATGAAATGCTGCAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075996174903205274					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137010	226137060	225949310	225949360	15133	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-26				GTGACACTCCAGCCACCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062489657071430157					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137136	226137186	225949436	225949486	15134	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-27				AAAACTCATCAGCTCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.073894549257361566					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137093	226137143	225949393	225949443	15135	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-28				TCAGCATTTGGCCTGCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50581576376555748					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136769	226136819	225949069	225949119	15136	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-29				TGACAGATAATTGGAAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0350431793552167					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136674	226136724	225948974	225949024	15137	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-3				TATCAATACCACAGCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80535935312753881					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226137041	226137091	225949341	225949391	15138	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-30				AAGCAAAAAGTGTTTCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38475905566527618					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136812	226136862	225949112	225949162	15139	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-31				ATAATGAATATGGAGTCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66398879916687392					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136528	226136578	225948828	225948878	15140	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-32				CTGACCTCACAGGATTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065462040000582214					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136577	226136627	225948877	225948927	15141	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-33				GATGGAAAATGTTAAAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0054838056455171					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136492	226136542	225948792	225948842	15142	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-34				TTCAACCACCTCCCTTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0019260589545339411					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136792	226136842	225949092	225949142	15143	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-35				TATTCTGAATTTTGTTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98995397926687989					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136402	226136452	225948702	225948752	15144	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-36				GTCTAAGCTTGCCAAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067506841463779388					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136711	226136761	225949011	225949061	15145	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-4				CACTCTGGAGATTAGGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042736904357851747					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136985	226137035	225949285	225949335	15146	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-5				TCCCTAATGAACATGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41344453620384181					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136503	226136553	225948803	225948853	15147	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-6				GAACTGCATCTCCGAGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50013325194411784					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136420	226136470	225948720	225948770	15148	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-7				ACACAGTGTTATCACACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.370683843672049					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136950	226137000	225949250	225949300	15149	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-8				CCACACTTGTGAGAAGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5021664472553331					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-16065	chr1	226136630	226136680	225948930	225948980	15150	hg38	N/A	N/A	N/A	Enhatls17637	enhancer	MIXL1e+10-9				AGAACGCTCCCTCTGCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35173680785494948					LEFTY2	chr1	225936597	225941383	5233				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16064
enhrx-lit139	chr1	226133548	226133598	225945848	225945898	15151	hg38					enhancer	MIXL1e+11-1				CAATGGTCTGATTAGTCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39010163444234508													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit140	chr1	226133225	226133275	225945525	225945575	15152	hg38					enhancer	MIXL1e+11-10				GCATGGAAAGAACTTTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18460849345928471													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit141	chr1	226133424	226133474	225945724	225945774	15153	hg38					enhancer	MIXL1e+11-11				ACAGGCCTGGGTCCTAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1583909170683869													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit142	chr1	226133677	226133727	225945977	225946027	15154	hg38					enhancer	MIXL1e+11-12				AAAGCCTCTTCTGTCCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1177694829592342													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit143	chr1	226133316	226133366	225945616	225945666	15155	hg38					enhancer	MIXL1e+11-13				GCTGGGGACTCAGTCAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45593996622917449													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit144	chr1	226133582	226133632	225945882	225945932	15156	hg38					enhancer	MIXL1e+11-14				TTCCACTGCATGACAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99835689165299712													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit145	chr1	226133626	226133676	225945926	225945976	15157	hg38					enhancer	MIXL1e+11-15				TGAGTGGAGAGTCTGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22588225671292													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit146	chr1	226133393	226133443	225945693	225945743	15158	hg38					enhancer	MIXL1e+11-16				CCAAATCCCCCAGACTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2182363954981093													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit147	chr1	226133247	226133297	225945547	225945597	15159	hg38					enhancer	MIXL1e+11-17				CAGGACTGGAAATAGTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3697046275302151													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit148	chr1	226133614	226133664	225945914	225945964	15160	hg38					enhancer	MIXL1e+11-18				CTCTCCACTCAGACCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00823511508700026													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit149	chr1	226133637	226133687	225945937	225945987	15161	hg38					enhancer	MIXL1e+11-19				TCTGGCTGTGGGGTCAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84756202228929478													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit150	chr1	226133279	226133329	225945579	225945629	15162	hg38					enhancer	MIXL1e+11-2				CAGATGACCCTACTGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0097481461538484263													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit151	chr1	226133746	226133796	225946046	225946096	15163	hg38					enhancer	MIXL1e+11-20				TCAATCAAAAATTACTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62585527921471873													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit152	chr1	226133531	226133581	225945831	225945881	15164	hg38					enhancer	MIXL1e+11-21				GATTGGGAAACTTTTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.086151781649887876													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit153	chr1	226133266	226133316	225945566	225945616	15165	hg38					enhancer	MIXL1e+11-22				TGGCTTCAGGGGGTCAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62376535855647752													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit154	chr1	226133600	226133650	225945900	225945950	15166	hg38					enhancer	MIXL1e+11-23				TGGAAGGAGCTGGGCCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066741701039955914													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit155	chr1	226133471	226133521	225945771	225945821	15167	hg38					enhancer	MIXL1e+11-24				GTTTGGGGAAATAAAATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.674014748171003													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit156	chr1	226133340	226133390	225945640	225945690	15168	hg38					enhancer	MIXL1e+11-25				TCGGGTCTGGGCAGGGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20583345552142329													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit157	chr1	226133370	226133420	225945670	225945720	15169	hg38					enhancer	MIXL1e+11-26				AGAAGCAGACAAACAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0632069007571929													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit158	chr1	226133701	226133751	225946001	225946051	15170	hg38					enhancer	MIXL1e+11-3				GGGACGGTGTTTGAAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.154058430466063													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit159	chr1	226133436	226133486	225945736	225945786	15171	hg38					enhancer	MIXL1e+11-4				GCTGCCGGGAATCCACATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42450499931080221													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit160	chr1	226133328	226133378	225945628	225945678	15172	hg38					enhancer	MIXL1e+11-5				GTCAACCCAGGGTCGGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50112419254122065													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit161	chr1	226133454	226133504	225945754	225945804	15173	hg38					enhancer	MIXL1e+11-6				GCAGCCTGAAGAGTTTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095315774577807058													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit162	chr1	226133406	226133456	225945706	225945756	15174	hg38					enhancer	MIXL1e+11-7				ACTCCTGAGGCCCAAGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22166044329056719													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit163	chr1	226133509	226133559	225945809	225945859	15175	hg38					enhancer	MIXL1e+11-8				CCAAAAGAAGAGCTTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6040531020915817													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit164	chr1	226133290	226133340	225945590	225945640	15176	hg38					enhancer	MIXL1e+11-9				TAGGGTCATCTGTCAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.048485371568791													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-16057	chr1	226091841	226091891	225904141	225904191	15177	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-1				ACCATGATACCTCATTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29071444692915221					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091779	226091829	225904079	225904129	15178	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-10				AGACAAATTTTCTGAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33360715878094321					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091695	226091745	225903995	225904045	15179	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-11				AGATAGTACTAAGTACTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90104544823038812					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091517	226091567	225903817	225903867	15180	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-12				AGCTGTTCTCTCTACTTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067258717358377726					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091652	226091702	225903952	225904002	15181	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-13				AGAGAGATAGTAATTGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9918733734681					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091600	226091650	225903900	225903950	15182	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-14				GGATAAGAGAGGCCTTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13866825962383739					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091563	226091613	225903863	225903913	15183	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-15				TTAACTTGTTCTTATCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.492722117860382					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091828	226091878	225904128	225904178	15184	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-16				ATTGTGCTGGTCATTGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99998678553728437					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091490	226091540	225903790	225903840	15185	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-17				CAAAGGCCCTGAGGTGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091717724055448577					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091588	226091638	225903888	225903938	15186	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-18				CGGATGTCACCTCCTCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26986582376422219					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091757	226091807	225904057	225904107	15187	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-2				GAAGCAACGCTCCAGCGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.558742003751775					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091746	226091796	225904046	225904096	15188	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-3				TCTATTGACTGCCTCCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.023489820321745371					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091548	226091598	225903848	225903898	15189	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-4				CAAGTTAACACGCAAAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51012917468066					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091882	226091932	225904182	225904232	15190	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-5				TGTCGAATGAATTAAAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.09071753034989799					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091811	226091861	225904111	225904161	15191	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-6				TCTAGGCACAGGGACATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1983675498944687					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091731	226091781	225904031	225904081	15192	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-7				TCAATAGATGGTTAAAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.882573414801052					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091664	226091714	225903964	225904014	15193	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-8				ACTATCTCTCTTTATCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4835039538651189					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226091611	226091661	225903911	225903961	15194	hg38	N/A	N/A	N/A	Enhatls17629	enhancer	MIXL1e+12-9				TATGTATGCATGGATAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.450130476645604					PYCR2	chr1	225919876	225924340	6722				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087499	226087549	225899799	225899849	15195	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-1				TGCGTGTTACAAACAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.153933946811517					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087097	226087147	225899397	225899447	15196	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-10				AGGGTCAGATAGGGCCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52749427327582943					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087314	226087364	225899614	225899664	15197	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-11				CCCATTGGAAATCCACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012437391551996489					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087314	226087364	225899614	225899664	15198	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-11				CCCATTGGAAATCCACATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012437391551996489					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087295	226087345	225899595	225899645	15199	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-12				TGGGTTCAAGAGTTTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29957415364414208					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087295	226087345	225899595	225899645	15200	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-12				TGGGTTCAAGAGTTTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29957415364414208					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087213	226087263	225899513	225899563	15201	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-13				CAATGGGCTGTTGCATCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01335843064834184					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086864	226086914	225899164	225899214	15202	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-14				GAGTCACATCCTGGCCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12853870676508419					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087434	226087484	225899734	225899784	15203	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-15				GTAAGACACTATTAATTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2321987793381278					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086800	226086850	225899100	225899150	15204	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-16				ACAGAGGTCAGAGGTCATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45381665851136349					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087179	226087229	225899479	225899529	15205	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-17				CCTCTGCATGACAAAGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50026371157200566					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087418	226087468	225899718	225899768	15206	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-18				TCACAGGACTGATTGGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1032589796632938					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086838	226086888	225899138	225899188	15207	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-19				TCACCTGGCAACCTGGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19564343948243909					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087485	226087535	225899785	225899835	15208	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-2				TAACACGCAGTTCACACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21368134599655331					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087074	226087124	225899374	225899424	15209	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-20				CAGGATGACTTCACAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20929277811668351					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087579	226087629	225899879	225899929	15210	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-21				AGTCATTCACAGCTGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.037181695967282928					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086994	226087044	225899294	225899344	15211	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-22				AAGCTCACCACCCCCACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076939073510907022					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087395	226087445	225899695	225899745	15212	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-23				CCTACTGATCTCCCTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010498136721236249					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087117	226087167	225899417	225899467	15213	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-24				GGGGGATCTGGCTGGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3094380759365709					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087229	226087279	225899529	225899579	15214	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-25				ATTGGGAGACTGTTTACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1283535668057898					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086849	226086899	225899149	225899199	15215	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-26				TGTGACTCCAACCAGAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47061583575032551					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087150	226087200	225899450	225899500	15216	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-27				ACCCACAGGCCTAGGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33941360780576729					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087470	226087520	225899770	225899820	15217	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-28				ACCCTGGGACCCTTCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3590999838463621					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087055	226087105	225899355	225899405	15218	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-29				AGGATGGCAGATGTGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15140554520495689					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087352	226087402	225899652	225899702	15219	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-3				TGCAGAGGGATAATAGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062611765210224					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087565	226087615	225899865	225899915	15220	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-30				TGAATGACTGGCATGTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16697350847795159					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087382	226087432	225899682	225899732	15221	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-31				GATCAGTAGGGGCAGACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37581361989313561					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086953	226087003	225899253	225899303	15222	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-32				CTTGAGGACATGATGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65095078377616122					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086953	226087003	225899253	225899303	15223	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-32				CTTGAGGACATGATGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65095078377616122					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087326	226087376	225899626	225899676	15224	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-33				AGAGACCTCTTTCCTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75652429671214749					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087326	226087376	225899626	225899676	15225	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-33				AGAGACCTCTTTCCTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75652429671214749					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087337	226087387	225899637	225899687	15226	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-34				AAAGAGGTCTCTGTTTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49348190567131928					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086915	226086965	225899215	225899265	15227	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-35				TAGGAGGGCAGATGAGGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70607551957941161					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087017	226087067	225899317	225899367	15228	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-36				GCAGGAAATGGGAGAACGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57003281283787532					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087610	226087660	225899910	225899960	15229	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-37				TGCCAGCCTGGCCTCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1851186273181438					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086878	226086928	225899178	225899228	15230	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-38				GCCACCCTCCTGCCCCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42185536006062929					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086812	226086862	225899112	225899162	15231	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-39				CTGACCTCTGTGTTTTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053401688069459941					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086784	226086834	225899084	225899134	15232	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-4				ATCGTGGGGCCTCCATGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67370230455995839					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087280	226087330	225899580	225899630	15233	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-40				TGCTGGGGAAATAAAATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.046065960716405348					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087515	226087565	225899815	225899865	15234	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-41				CAGGCTCTTTTCTTGACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24312178937369749					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086772	226086822	225899072	225899122	15235	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-42				GTCCAGCTCATCCCCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82385392550138892					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087407	226087457	225899707	225899757	15236	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-43				ATTGGGTGTGGGCCAGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1502523647614389					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087168	226087218	225899468	225899518	15237	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-44				GTCATGCAGAGGAAGGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36688756557282148					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087042	226087092	225899342	225899392	15238	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-45				CTGCCATCCTGGAGGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050890454384578017					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087452	226087502	225899752	225899802	15239	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-46				CTTACCCTCTCTCCAACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12975552571230339					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086983	226087033	225899283	225899333	15240	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-47				CCAGGGCTGGGCCCTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4449751403223221					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087197	226087247	225899497	225899547	15241	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-48				TGGGGCTGCCCTCCCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.150200498563264					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087597	226087647	225899897	225899947	15242	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-49				CAGGCTGGCAGTGGGAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5426208989134991					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086965	226087015	225899265	225899315	15243	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-5				ATGTCCTCAAGTTCAGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.431178391068188					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086965	226087015	225899265	225899315	15244	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-5				ATGTCCTCAAGTTCAGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.431178391068188					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087028	226087078	225899328	225899378	15245	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-50				GGCAGCAGGGGGCAGGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18217017452122769					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086890	226086940	225899190	225899240	15246	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-51				AGGAGGGTGGCTGAGGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.954153452463013					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087534	226087584	225899834	225899884	15247	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-52				ATAGAGGAGAAAAGAGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32380214143150432					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086930	226086980	225899230	225899280	15248	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-53				AGGAGGAGGACCAGGTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41443537375726452					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087136	226087186	225899436	225899486	15249	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-54				CCCCACCCCCACCCACCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087249	226087299	225899549	225899599	15250	hg38	N/A	enh47300	fant5028	Enhatls17629	enhancer	MIXL1e+13-6				AATCCACATTCGCTTTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24526583587847231					LEFTY1	chr1	225886281	225889146	10135				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087621	226087671	225899921	225899971	15251	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-7				GATTCTGGTGCCCATTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46530704235795411					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226087550	226087600	225899850	225899900	15252	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-8				TGAAGTGGCACTTGGTATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29732769658861541					LEFTY1	chr1	225886281	225889146	10485				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16057	chr1	226086823	226086873	225899123	225899173	15253	hg38	N/A	enh47300	N/A	Enhatls17629	enhancer	MIXL1e+13-9				GTTTTCCCATGGCCCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28786067289891631					LEFTY1	chr1	225886281	225889146	8259				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16056
enhrx-16029	chr1	225960220	225960270	225772518	225772568	15254	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-1				AGGGAGTCCTGACACCAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45840052902846218					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960185	225960235	225772483	225772533	15255	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-10				TTTGATTCAGTGTCCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36527116698604378					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960059	225960109	225772357	225772407	15256	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-11				CAACATGATTTCAGCTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.001370013852491534					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960254	225960304	225772552	225772602	15257	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-12				GGTTGTGTCCCAGATAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65757268474487					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960206	225960256	225772504	225772554	15258	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-13				AAGCTGCCCCAGACCCACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0446899982809781					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960327	225960377	225772625	225772675	15259	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+14-14				GATTCAATGCAAGGCAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14974521284598041					SRP9	chr1	225777812	225790468	5001				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960313	225960363	225772611	225772661	15260	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-15				CAGACAGGGTAAAACAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.026389629776091258					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960313	225960363	225772611	225772661	15261	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+14-15				CAGACAGGGTAAAACAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.026389629776091258					SRP9	chr1	225777812	225790468	5001				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960295	225960345	225772593	225772643	15262	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-16				CTTGGTTGGCTTCTCTTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1119968128981208					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960295	225960345	225772593	225772643	15263	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+14-16				CTTGGTTGGCTTCTCTTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1119968128981208					SRP9	chr1	225777812	225790468	5001				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225959973	225960023	225772271	225772321	15264	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-17				TAAACTGGATTGGAGATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44859618522517147					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960011	225960061	225772309	225772359	15265	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-18				TCTCAACACTTCCTTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01418788418904466					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960121	225960171	225772419	225772469	15266	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-19				AGGGCTGACTCCAGCCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3307597501369926					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960277	225960327	225772575	225772625	15267	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-2				TCCTGGGCAAACCGGTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.041186225807508373					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960277	225960327	225772575	225772625	15268	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+14-2				TCCTGGGCAAACCGGTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.041186225807508373					SRP9	chr1	225777812	225790468	5001				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960023	225960073	225772321	225772371	15269	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-20				AAGTGTTGAGATTGAGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45303718267462217					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960172	225960222	225772470	225772520	15270	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-21				TGCACACCACTGCCCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12520521482850319					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960240	225960290	225772538	225772588	15271	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-22				TAGGGAGGGAAGGAAACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52006570651229955					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225959958	225960008	225772256	225772306	15272	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-23				AAGGAATTAATAAATTAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515908					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225959927	225959977	225772225	225772275	15273	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-3				TAGGGTGACAGGCCCGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057072366095946889					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225959939	225959989	225772237	225772287	15274	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-4				CCCGGATTAGGTGCTCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0191807228872909					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225959991	225960041	225772289	225772339	15275	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-5				AGGGCTCTCATTTGATTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29973115122478661					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960085	225960135	225772383	225772433	15276	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-6				TATGTACTGATGTACTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68595650635062633					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960107	225960157	225772405	225772455	15277	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-7				GCGACCATTTCCTTCCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13743845752599521					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960340	225960390	225772638	225772688	15278	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+14-8				GCATTGAATCCATGAAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1014557106902616					SRP9	chr1	225777812	225790468	5001				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225960140	225960190	225772438	225772488	15279	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+14-9				ACAGAGACAGCCATCCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79649349539438752					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956859	225956909	225769157	225769207	15280	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-1				AACCAATTAGGTGTCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86684313753227749					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957065	225957115	225769363	225769413	15281	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-10				TTTTAGAGGCAACAGGGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4151706842130779					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956927	225956977	225769225	225769275	15282	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-11				CGCCCTGAGCTGGGAACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.250048545047895					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957079	225957129	225769377	225769427	15283	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-12				CTCGACTTAATTTTTTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17788668002402541					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957119	225957169	225769417	225769467	15284	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-13				GGACTGGAACATGGTGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090563890425536323					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957054	225957104	225769352	225769402	15285	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-14				ACAGGGTTAGGGACTGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28056849744666562					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957017	225957067	225769315	225769365	15286	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-15				ATGCTGGCTCTTGCAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26099325902173309					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956819	225956869	225769117	225769167	15287	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-16				AGCTGGGAACAGTGGCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10843647185764881					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956895	225956945	225769193	225769243	15288	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-17				GGAGAAGATAAGCCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.166310135891976					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956916	225956966	225769214	225769264	15289	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-18				GGGAACTGTGGGAGGACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9951080209172759					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956972	225957022	225769270	225769320	15290	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-19				CAGTAAGTAAAGGGAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.106686927027585					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956986	225957036	225769284	225769334	15291	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-2				TACTTACTGCGAGAAAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01638107012419698					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957135	225957185	225769433	225769483	15292	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-20				CTGGAGTGGGCAGTGAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053528173015424257					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956882	225956932	225769180	225769230	15293	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-3				ATGATTTCACCCCCCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01291305610983585					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956871	225956921	225769169	225769219	15294	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-4				GGGTGAAATCATAACCAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.338952454600901					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957033	225957083	225769331	225769381	15295	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-5				GGAGCTTAGTGTGGCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1147953716398547					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956795	225956845	225769093	225769143	15296	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-6				GATAATGGAGTGATAAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52713899981206047					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225956841	225956891	225769139	225769189	15297	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-7				GTCTGAGTCGAGAAGGATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.07826015697809989					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957001	225957051	225769299	225769349	15298	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-8				AGCTGTGGTTATCAGCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17594984466623109					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225957092	225957142	225769390	225769440	15299	hg38	N/A	enh12725	N/A	Enhatls17591	enhancer	MIXL1e+15-9				TTAAGTCGAGACAGGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37718297892782932					SRP9	chr1	225777812	225790468	5200				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865091	225865141	225677389	225677439	15300	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-1				AGCGAGGCTCGCCTCCGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.044131391552612					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865189	225865239	225677487	225677537	15301	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-10				AGTCTGGAGGGCCGAAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03121430724977171					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865080	225865130	225677378	225677428	15302	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-11				ATTTGAGCCACCCCACACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29790246580904511					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865331	225865381	225677629	225677679	15303	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-12				GTCCATCAATTCTCTCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07051130621875927					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865135	225865185	225677433	225677483	15304	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-13				GCGACTGAATGAAGCCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082729090787206708					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865032	225865082	225677330	225677380	15305	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-14				CCCCCAGTGCTAGACAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44286911034435972					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865201	225865251	225677499	225677549	15306	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-15				CAGTCCGGGCCCAGTCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2257721449994039					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865216	225865266	225677514	225677564	15307	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-16				GGCTGCTGCGGGGGTCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066426594859946342					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865165	225865215	225677463	225677513	15308	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-17				CCGGGGATGCTGCCTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4090034061517569					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865237	225865287	225677535	225677585	15309	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-18				TCCAGCCCTCCGGAGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3842607271984009					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865013	225865063	225677311	225677361	15310	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-19				GGGGTGGAGAAAAAACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072931155883893983					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865146	225865196	225677444	225677494	15311	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-2				TCATTCAGTCGCGCCGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14181846138969231					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225864984	225865034	225677282	225677332	15312	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-20				TGAATTTTGATGAATCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0058389742013525156					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865301	225865351	225677599	225677649	15313	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-21				GCGGCTCCCGGGAAGGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82806649483228811					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865425	225865475	225677723	225677773	15314	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-22				TGTCACCCAGAGGGAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20343633720757459					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865287	225865337	225677585	225677635	15315	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-23				GGCCCCAGGGCCCCAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33979662349144418					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865414	225865464	225677712	225677762	15316	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-24				GGGAAAGAAAGGAGAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77844828958206691					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865107	225865157	225677405	225677455	15317	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-3				CTGTAACCGAGGCGCTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01391597084328567					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865065	225865115	225677363	225677413	15318	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-4				GCTCAAATGGCTGCGAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2792701833591329					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865121	225865171	225677419	225677469	15319	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-5				CGGTTACAGCCTTTCCCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068976960722236552					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865394	225865444	225677692	225677742	15320	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-6				GGGATTCCCTTTCGATGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53084090160787811					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865177	225865227	225677475	225677525	15321	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-7				CGAAGCACCGGCCCGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1217508875166159					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865276	225865326	225677574	225677624	15322	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-8				ACAGCCGCGCTCCGAGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21886221119948179					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16029	chr1	225865316	225865366	225677614	225677664	15323	hg38	N/A	N/A	N/A	Enhatls17591	enhancer	MIXL1e+16-9				GGAGCCGCCACCGGCCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1121527851072515					ENAH	chr1	225486764	225653142	20512				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16028
enhrx-16027	chr1	225815196	225815246	225627494	225627544	15324	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-1				AATCACTGCAAAGTGGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13424409464191911					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815239	225815289	225627537	225627587	15325	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-10				GAGTGCTGTTATGAGGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14423411318878041					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815219	225815269	225627517	225627567	15326	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-11				CTCAGCACAGTTGACCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.514253394226097					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815395	225815445	225627693	225627743	15327	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-12				GAAATCATTAACAACTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0093936269598164333					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815417	225815467	225627715	225627765	15328	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-13				TCACTGCTACTTCTTTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.721159288307776					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815153	225815203	225627451	225627501	15329	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-14				AAGATACAGCCAATGAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19653509836893529					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815504	225815554	225627802	225627852	15330	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-15				ACCACTGGGCTTGGTGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70652126752633837					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815166	225815216	225627464	225627514	15331	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-16				TGAGATAAGGAGAGAACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27640870757719288					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815518	225815568	225627816	225627866	15332	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-17				CTCTTCTCCACTCCACCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26935886593670783					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815358	225815408	225627656	225627706	15333	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-18				AAATTATCTAACAAGTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.300796714065638					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815344	225815394	225627642	225627692	15334	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-19				AGATAATTTAGTATTAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1162997764484368					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815278	225815328	225627576	225627626	15335	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-2				CCCTGTTATCAACTTTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18880915149570041					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815100	225815150	225627398	225627448	15336	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-20				TGGAGGAGGGGAAGACTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6757472229728384					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815118	225815168	225627416	225627466	15337	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-21				ATGGGGAGAAGAAAATGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2175162029520574					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815464	225815514	225627762	225627812	15338	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-3				ATTCAGTAGCCACCTTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24912733062429709					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815066	225815116	225627364	225627414	15339	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-4				GCACACAGGTTGTAAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054109075636986248					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815083	225815133	225627381	225627431	15340	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-5				CCCAGGGAGTAACATTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18884058171002119					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815182	225815232	225627480	225627530	15341	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-6				GCAGTGATTTTAAGCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51416825852926162					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815446	225815496	225627744	225627794	15342	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-7				CTACATCTAATTAGCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29720885905389388					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815265	225815315	225627563	225627613	15343	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-8				GATAACAGGGAGGTCTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28291769983645287					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16027	chr1	225815311	225815361	225627609	225627659	15344	hg38	N/A	enh64193	N/A	Enhatls17590	enhancer	MIXL1e+17-9				CCTGACCCTCCTTCTATTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53645152692652864					ENAH	chr1	225486764	225653142	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16026
enhrx-16014	chr1	225612518	225612568	225424816	225424866	15345	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-1				CAAGAACTGCCACTTACGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69458801044451335					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612686	225612736	225424984	225425034	15346	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-10				ACTAGCTGGGGCCACGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24325458220528939					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612759	225612809	225425057	225425107	15347	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-11				TACATCAAGAAGTGCTTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17372034496988381					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612379	225612429	225424677	225424727	15348	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-12				TTGGATGAAGGCAACCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1148633073009146					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613059	225613109	225425357	225425407	15349	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-13				AGTACTTATCTGGTGATTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.224912509286409					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613006	225613056	225425304	225425354	15350	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-14				GCTCTACTAGTTTACAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43414758587039193					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613152	225613202	225425450	225425500	15351	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-15				ACTGGGGTAATGAATGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21886358933024019					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612888	225612938	225425186	225425236	15352	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-16				AGTTGAATTACCTACCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51266308220520673					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612457	225612507	225424755	225424805	15353	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-17				TGGGCCATGTTTTGAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01421560928116751					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612902	225612952	225425200	225425250	15354	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-18				ACTCTCCCACTACTCCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2153479498316612					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612786	225612836	225425084	225425134	15355	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-19				GGAATGTACATTGATAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13670888093396269					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612612	225612662	225424910	225424960	15356	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-2				TGATTCCGCTGGTCAGCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39949633117324251					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613273	225613323	225425571	225425621	15357	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-20				TTATGCCCCTGCTCATGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.117977015114663					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612853	225612903	225425151	225425201	15358	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-21				TTAGGAACCTTTGAAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66914017552780258					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612818	225612868	225425116	225425166	15359	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-22				TTGTATCATCAGCTCTTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57252856132690977					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612699	225612749	225424997	225425047	15360	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-23				ACGTCCAAGGGGCAGCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27899181385086852					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612365	225612415	225424663	225424713	15361	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-24				ACCACCCACCTAAGCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70564260163668957					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612504	225612554	225424802	225424852	15362	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-25				CAGTTCTTGCAGATTGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63389794738520189					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612541	225612591	225424839	225424889	15363	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-26				TTTCAAAAAGGGTGGCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1225222263652218					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612714	225612764	225425012	225425062	15364	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-27				ACAGCTCATATCTGTCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6057502767918822					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613136	225613186	225425434	225425484	15365	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-28				CCTGAGATTGGGCATCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3366260160788726					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613136	225613186	225425434	225425484	15366	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-28				CCTGAGATTGGGCATCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3366260160788726					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612640	225612690	225424938	225424988	15367	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-29				GCAGCCCTGGTTTTGTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36896338906407461					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612596	225612646	225424894	225424944	15368	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-3				AGACAGTAATGCCGCTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51171076373915947					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612807	225612857	225425105	225425155	15369	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-30				GCTCTTAACAGGAGCCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1134970303274809					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612349	225612399	225424647	225424697	15370	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-31				GGGTGGTTGGCAGAGTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23594567476060069					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613324	225613374	225425622	225425672	15371	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-32				TCTGAGCTAAATGTTGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26943716794477329					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612963	225613013	225425261	225425311	15372	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-33				CGATTAACAGTGAAAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15352454245996811					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613092	225613142	225425390	225425440	15373	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-34				ATTAACACATTAGGTAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0243056193363129					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612428	225612478	225424726	225424776	15374	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-35				ATGTTATAATTGGGGGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72814216271035115					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613168	225613218	225425466	225425516	15375	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-36				GGTTTGGGCTTGGAGTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77557084929297437					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612558	225612608	225424856	225424906	15376	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-37				TTGAAATATCAATTGATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17308944103800469					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613220	225613270	225425518	225425568	15377	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-38				AGGCCTGGCTGAGTCACCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41897586632405942					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613018	225613068	225425316	225425366	15378	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-39				TACAGAGATGGCAGCTAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19977363061312259					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612672	225612722	225424970	225425020	15379	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-4				CCAGTACCACATGAACTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.015987320934859779					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612740	225612790	225425038	225425088	15380	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-40				TTGGTGAAATGAAGGTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42350420831362862					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612950	225613000	225425248	225425298	15381	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-41				AAAAATGTGGTGGTTAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63510235881264976					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612391	225612441	225424689	225424739	15382	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-42				AGAGAAGTGAGCTTGGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.266268475813089					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612653	225612703	225424951	225425001	15383	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-43				CTGGGGAAGGTCGGCAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13364074964405451					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612835	225612885	225425133	225425183	15384	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-44				ATACAATAAAAGCAACATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.1086463374501987					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612913	225612963	225425211	225425261	15385	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-45				TAGTGGGAGAGTGGGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1096091101639449					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612924	225612974	225425222	225425272	15386	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-46				TGGGGGGGGAGGCGGGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3773435329934649					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613231	225613281	225425529	225425579	15387	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-5				AGTCACCCGAGGGGCACTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56332142250441686					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612623	225612673	225424921	225424971	15388	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-6				GTGTGGAAATGTGATTCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039352516109193228					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613197	225613247	225425495	225425545	15389	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-7				GACTTCATCCCGAAAACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14767983885471761					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613125	225613175	225425423	225425473	15390	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-8				CCCTACACCTACCTGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11248943564392069					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225613125	225613175	225425423	225425473	15391	hg38	N/A	enh89539	fant5012	Enhatls17576	enhancer	MIXL1e+18-8				CCCTACACCTACCTGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11248943564392069					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-16014	chr1	225612476	225612526	225424774	225424824	15392	hg38	N/A	enh89539	N/A	Enhatls17576	enhancer	MIXL1e+18-9				TAGAGTATTGTGGGGCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1102779027520412					LBR	chr1	225401501	225428925	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16013
enhrx-15966	chr1	225415010	225415060	225227308	225227358	15393	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-1				TGTCCCTGGGTACTTGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76145935542601506					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414877	225414927	225227175	225227225	15394	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-10				TGTCAGGCTGGGGGATGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30242394272919432					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414986	225415036	225227284	225227334	15395	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-11				AATGCACTGCGGAAGGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20973500776948009					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225415052	225415102	225227350	225227400	15396	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-12				GTGTTTGCAGGCAGTATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2467716417053348					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414908	225414958	225227206	225227256	15397	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-13				TTCCCATGAGGCCATATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9121117623706565					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414833	225414883	225227131	225227181	15398	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-14				GGAGGATTAGTGAAAGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57949943430129025					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414865	225414915	225227163	225227213	15399	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-15				ACCCTTTACGGGTGTCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13456787163025					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414896	225414946	225227194	225227244	15400	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-16				CAGGTCTTTCCCTTCCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52606707268750086					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414854	225414904	225227152	225227202	15401	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-18				CCTCAGCACAGACCCTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0050618013406361					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225415064	225415114	225227362	225227412	15402	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-2				TTTGTTAAAATTGTGTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86423673478935359					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414735	225414785	225227033	225227083	15403	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-3				AGTAAATAGAATGTACAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2979327401223428					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414933	225414983	225227231	225227281	15404	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-4				GTCTCAGTAGGGGGAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4081222231547352					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414773	225414823	225227071	225227121	15405	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-5				TTTCATTCCCAGGGATGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020263918241179742					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414945	225414995	225227243	225227293	15406	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-6				GGAAACCTTGGACAATACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03915430495150192					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414997	225415047	225227295	225227345	15407	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-7				CCGCAGTGCATTGTGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1429398008066276					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414922	225414972	225227220	225227270	15408	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-8				TATCTCAGGCTGTCTCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.397968948285881					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414962	225415012	225227260	225227310	15409	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19-9				ACCTCTGCCCAAGAAAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0614322978903596					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225414810	225414860	225227108	225227158	15410	hg38	N/A	enh12721	N/A	Enhatls17525	enhancer	MIXL1e+19/NANOGe-14				CTCTTATCTCAACTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.011449662898107329					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-16082	chr1	226398437	226398487	226210736	226210786	15411	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-1				GTACTTGTGAAGCCCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8709376774624218					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398815	226398865	226211114	226211164	15412	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-10				ACCAGACAGTTGCTCTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6127680681510448					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398268	226398318	226210567	226210617	15413	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-11				CTTGTGGGCCTCCATCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.85879583719839					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398424	226398474	226210723	226210773	15414	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-12				CCACCGGCATCACCCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1967717434032146					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398299	226398349	226210598	226210648	15415	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-13				GGACTTGTGACAACATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9023405699404652					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398984	226399034	226211283	226211333	15416	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-14				TGGGCAGGACTCCATGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.5131295663514353					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398751	226398801	226211050	226211100	15417	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-15				CAGTTGACAGAAACCTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4632079278072894					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398635	226398685	226210934	226210984	15418	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-16				CCACTTCCCCATTTCAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5515376336957907					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398310	226398360	226210609	226210659	15419	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-17				TGTCACAAGTCCCCTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.24871523178377					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398925	226398975	226211224	226211274	15420	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-18				GCAGTGGTTGTAGGAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.86310398402117					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398907	226398957	226211206	226211256	15421	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-19				GCTGGAACCCCAACTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1056849251529188					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398243	226398293	226210542	226210592	15422	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-2				CGCCTTGGTAACTTCAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1846784712860039					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398568	226398618	226210867	226210917	15423	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-20				ACTTTTCACGGCACTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6177001725289739					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398592	226398642	226210891	226210941	15424	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-21				TCAACTATCAAAGAACCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7238598826969174					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398529	226398579	226210828	226210878	15425	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-22				CCCAAGACCCTTTCATCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3488102657036443					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398369	226398419	226210668	226210718	15426	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-23				CGCGAGGGGGGATGGGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8253682890203091					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399186	226399236	226211485	226211535	15427	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-24				TTGATGCTGCAGATTTCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4836166556391559					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399126	226399176	226211425	226211475	15428	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-25				TGCCGTCCATGGCCTCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.422231432519828					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398545	226398595	226210844	226210894	15429	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-26				CTCAGATGAAAGGCAGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3539389136461191					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398490	226398540	226210789	226210839	15430	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-27				CTCCAAGGCTTCAAAAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59529299529248081					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398869	226398919	226211168	226211218	15431	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-28				TGAATCTCAGCAACTTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.546955864708607					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398693	226398743	226210992	226211042	15432	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-29				AGATTTGCAGCTTTACAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.508124707835687					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398385	226398435	226210684	226210734	15433	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-3				TCAGTCACACCTAGGGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8162815630130318					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398475	226398525	226210774	226210824	15434	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-30				TTCCTCTTGCCGCTCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.33500108950422					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399022	226399072	226211321	226211371	15435	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-31				TGCTCATCTTGGATCCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9680979896530344					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398322	226398372	226210621	226210671	15436	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-32				AATCTGTGATTTCCCTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8930025015116447					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398858	226398908	226211157	226211207	15437	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-33				TGCTGAGATTCAAGAGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.89482260244671					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398193	226398243	226210492	226210542	15438	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-34				GATGTGTCAAAGGAGAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6448541119563558					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399076	226399126	226211375	226211425	15439	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-35				TGTGGTGAGATGTGACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7875692002921291					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398973	226399023	226211272	226211322	15440	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-36				CACTGAGTTTGCCATTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.435797738389875					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398725	226398775	226211024	226211074	15441	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-37				TATCTCAAAAAGGAACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5503820870875629					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398710	226398760	226211009	226211059	15442	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-38				AAATCTTCAGCTCTGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.362157038063172					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399137	226399187	226211436	226211486	15443	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-39				ACAGCCCCTCCTGCCGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0569398860837271					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398351	226398401	226210650	226210700	15444	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-4				GCGGGAGGACAGCGCTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8807431698777188					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399244	226399294	226211543	226211593	15445	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-40				CCAAGATACTCCATGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0619656072636339					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399098	226399148	226211397	226211447	15446	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-41				GCAGTGTGAGTGCCTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7514258131926574					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398764	226398814	226211063	226211113	15447	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-42				GGGGTTCTTTCAGCCCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0002176857628671					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399033	226399083	226211332	226211382	15448	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-43				TTTTTCAGGTGTGCTCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.77405284689739					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398785	226398835	226211084	226211134	15449	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-44				CTCTTTCTGGAAGACTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7166893312373119					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399047	226399097	226211346	226211396	15450	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-45				TGCAAAGTCAGTGTTTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040119050406601978					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398798	226398848	226211097	226211147	15451	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-46				TCTGGTTCACTATCTCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4874852964726988					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398580	226398630	226210879	226210929	15452	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-47				TTGATAGTTGAAACTTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4384511956330721					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398459	226398509	226210758	226210808	15453	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-48				AGAGGAAGTGGTCAGCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.228361545254411					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398284	226398334	226210583	226210633	15454	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-49				TGCTGAGGAAACTGGGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5975430906226764					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398949	226398999	226211248	226211298	15455	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-5				TGAGCGACCACCATTTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8016607382082679					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398675	226398725	226210974	226211024	15456	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-50				GAGAAGCTGACAGTTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1324009579590557					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398892	226398942	226211191	226211241	15457	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-51				TTCCTTACCTCTGCACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2374598308529929					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399058	226399108	226211357	226211407	15458	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-52				ACTGACTTTGCAGAGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3364483070191282					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398646	226398696	226210945	226210995	15459	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-53				TTTCAATGCTGGCAAAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7835031167699871					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398606	226398656	226210905	226210955	15460	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-54				ACCCCCAGGAAGAAGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.500641772062691					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398845	226398895	226211144	226211194	15461	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-55				GAGGATAAGGACAAGGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1797079127925691					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399110	226399160	226211409	226211459	15462	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-56				CACCTGGCCAGGCCCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8211421023813976					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399008	226399058	226211307	226211357	15463	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-57				CAGGAGCTCACAGACCAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1754062370084171					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398205	226398255	226210504	226210554	15464	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-58				TTTGACACATCTGGAAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.12604550417977					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398220	226398270	226210519	226210569	15465	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-59				AACTAAGGCTCAGAGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4678414773403974					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399220	226399270	226211519	226211569	15466	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-6				GATTCTTCCTACACTAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4139075438921549					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398508	226398558	226210807	226210857	15467	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-7				GGGCCATATTAAGTTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2798720408093516					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226398408	226398458	226210707	226210757	15468	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-8				TTGGCATGCTAATTCCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8961443072061286					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226399277	226399327	226211576	226211626	15469	hg38	N/A	enh74489	N/A	Enhatls17655	enhancer	MIXL1e+2-9				GTTCATTACTATGCACACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1712293730587269					MIXL1	chr1	226223617	226227060	11644				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-15966	chr1	225412390	225412440	225224688	225224738	15470	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-1				TTACCAGAAGCGTTAGGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2821206448453174					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412117	225412167	225224415	225224465	15471	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-10				GGGAGATAATGTTTTAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22771110769406691					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412415	225412465	225224713	225224763	15472	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-11				ATAGAAAAGCAGCTATTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43676199745757721					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412279	225412329	225224577	225224627	15473	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-12				ATAGCACTCTCTGATTATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16449203481783939					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412302	225412352	225224600	225224650	15474	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-13				CAGGAAGGGCATGTTTTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59094203386704436					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412145	225412195	225224443	225224493	15475	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-14				AGATGACTTTACTAACTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48486099358769208					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412369	225412419	225224667	225224717	15476	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-15				GGGGAGTGAACTACTTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25635403592210071					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412078	225412128	225224376	225224426	15477	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-2				CAGGCTGCACTTTCTAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15751288191286719					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412453	225412503	225224751	225224801	15478	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-3				CTCACTCATTCTGGATTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1108422790482483					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412260	225412310	225224558	225224608	15479	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-4				CTATCTGAAAATCTAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16450613518538809					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412175	225412225	225224473	225224523	15480	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-5				GCAACTGACTGCATCATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56047381159600373					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412317	225412367	225224615	225224665	15481	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-6				GAATTAGTTTCTCAGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41978500895159993					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412357	225412407	225224655	225224705	15482	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-7				ACTTTTGTAGGCACAACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23375365433981379					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412209	225412259	225224507	225224557	15483	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-8				CAAAGAATTCTGATGACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46324202148259841					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15966	chr1	225412099	225412149	225224397	225224447	15484	hg38	N/A	N/A	N/A	Enhatls17525	enhancer	MIXL1e+20-9				GGTTTTTTTACTCACATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40074926220302221					DNAH14	chr1	224896261	225399292	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15965
enhrx-15928	chr1	225068330	225068380	224880628	224880678	15485	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-1				TTCCCAGTGTGCAAACAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.088779135733014491					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068257	225068307	224880555	224880605	15486	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-10				TTATTTACTATTTCAGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.6064633300101541					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068505	225068555	224880803	224880853	15487	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-11				GCAGGGTTTATTCGGTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66802688307119185					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068399	225068449	224880697	224880747	15488	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-12				GCCTGGCCTCTGCTGTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1090310101582118					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068426	225068476	224880724	224880774	15489	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-13				AACCAGGGATTCCATCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.078262575383944918					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068523	225068573	224880821	224880871	15490	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-14				CTTTGAAGGGTGAGAAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.194038586408438					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068349	225068399	224880647	224880697	15491	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-15				GGAAGATGGGGTGGAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1705830110746669					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068548	225068598	224880846	224880896	15492	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-16				TCTGCAAGCCTAACCTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98801731073148713					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068537	225068587	224880835	224880885	15493	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-17				TAGGCTTGCAGACACTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039188224529073043					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068488	225068538	224880786	224880836	15494	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-18				AAAAGGAAAAAAAGGAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59577709626205277					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068317	225068367	224880615	224880665	15495	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-2				AACAGGTCGGAGATTCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.000516681108749337					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068437	225068487	224880735	224880785	15496	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-3				CAGGCTTCCCGCCTCACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.122360163330552					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068375	225068425	224880673	224880723	15497	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-4				TTTGTGCAGTTTGCAGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56751535251433161					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068585	225068635	224880883	224880933	15498	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-5				GAATTGTTGTAGGAAAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5750437045302873					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068561	225068611	224880859	224880909	15499	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-6				TCTTGTCACATGACCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2183986418405091					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068456	225068506	224880754	224880804	15500	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-7				AATGCGAGAATCCTGCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12225898556706349					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068301	225068351	224880599	224880649	15501	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-8				TCCGGGGAGCCCTTTTAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54860098948747682					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225068411	225068461	224880709	224880759	15502	hg38	N/A	enh43158	N/A	Enhatls17487	enhancer	MIXL1e+21-9				CTGTTTCTGGGTGGTAACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.080520652154965067					DNAH14	chr1	224896261	225399292	9609				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007546	225007596	224819844	224819894	15503	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-1				GTACTGCAAGGGCATATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73899883661319976					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007720	225007770	224820018	224820068	15504	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-10				TATCTGCAGATGCTCATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28925397766887762					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007400	225007450	224819698	224819748	15505	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-11				GCACCCAGGATGAGATGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2724288443836471					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007889	225007939	224820187	224820237	15506	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-12				TTGTTGCATGCTTTCTAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.084786500732961845					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007785	225007835	224820083	224820133	15507	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-13				TGTTATCTTACTGATAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007861	225007911	224820159	224820209	15508	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-14				GTATAGAAAGTGCTCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	5.7005518615385243E-05					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007699	225007749	224819997	224820047	15509	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-15				GGCCTCCTTGTGCTCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1582934447310605					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007611	225007661	224819909	224819959	15510	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-16				TCAGTGAATATCTGCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28248467499487312					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007934	225007984	224820232	224820282	15511	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-17				TTACTTGGGGGTAGAAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27700246070955842					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007919	225007969	224820217	224820267	15512	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-18				CCAATATAATTCTATTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.954938953790184					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007670	225007720	224819968	224820018	15513	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-19				AACTGAAAACAATGAGGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.350987696049164					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007625	225007675	224819923	224819973	15514	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-2				AACTTGCCAGCTAACCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69627574472460607					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007494	225007544	224819792	224819842	15515	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-20				TTAGCCCAGCACTCCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18630736837347731					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007508	225007558	224819806	224819856	15516	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-21				TCAAGGAAAGCTTCCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23438994027928189					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007468	225007518	224819766	224819816	15517	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-22				GATAAAGGCTTGTGGGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45651265399526919					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007428	225007478	224819726	224819776	15518	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-23				GGAGCTGAAGGAAAGTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46279761698024569					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007414	225007464	224819712	224819762	15519	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-24				GTCTGGGGGAGAGGGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.547983514836293					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007568	225007618	224819866	224819916	15520	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-25				TAAGAACAAAAAGAGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48764709071416568					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007811	225007861	224820109	224820159	15521	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-26				GATAATGTTATCTACCACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23185656645687869					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007440	225007490	224819738	224819788	15522	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-3				GAGCGTACTCAAGGAGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21287405298392659					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007685	225007735	224819983	224820033	15523	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-4				TTTCAGTTCCTAACCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5798725000803371					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007557	225007607	224819855	224819905	15524	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-5				AGAGCCACATGGTACTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064146256538378008					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007648	225007698	224819946	224819996	15525	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-6				GAGACGTGTCCTCAGTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3097214512048404					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007483	225007533	224819781	224819831	15526	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-7				GTGCTGGGCTAAGAGGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016020643722685191					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007830	225007880	224820128	224820178	15527	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-8				TAGGAGCATTGTGAGGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38972538844107152					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	225007534	225007584	224819832	224819882	15528	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+22-9				CATATACCAGGGAGATGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57720567247835186					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988351	224988401	224800649	224800699	15529	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-1				GACATAAGGACGTGTGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047039276357430333					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988601	224988651	224800899	224800949	15530	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-10				AGACATGACAAAATCCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21742042018666191					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988489	224988539	224800787	224800837	15531	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-11				AAATGGTACTGGAAAAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55278040145182994					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988445	224988495	224800743	224800793	15532	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-12				CAGGGGCAGAGTCAGACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0928626879643588					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988524	224988574	224800822	224800872	15533	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-13				TGAGAGGTTGGGGGTGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36125380034555149					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988623	224988673	224800921	224800971	15534	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-14				GAAGACAAAGGGGAGCAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42294471429289188					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988462	224988512	224800760	224800810	15535	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-15				ACTCACAGATGGCAAAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042135861673422953					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988500	224988550	224800798	224800848	15536	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-16				AAAAAAGAATCAAATGGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99314860438796992					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988512	224988562	224800810	224800860	15537	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-17				GATTCTTTTTTTTGAGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58889417323453408					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988434	224988484	224800732	224800782	15538	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-2				TCAGACTTCAGGGCATCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43153694507665419					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988368	224988418	224800666	224800716	15539	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-3				GCTCTCACCATCTGTCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90843610517547746					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988409	224988459	224800707	224800757	15540	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-4				AGCTTGCCAGCTCTTGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18161285748939759					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988552	224988602	224800850	224800900	15541	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-5				GGGACTCTTTTACTTGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0023877260359503622					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988574	224988624	224800872	224800922	15542	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-6				ACTGTAACTCCTTGTTTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53723779822592255					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988473	224988523	224800771	224800821	15543	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-7				GCACAGGAGCAACTCACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.045427089813946032					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988337	224988387	224800635	224800685	15544	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-8				TGTCACAGAGTGAAGACATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16631148338597371					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15928	chr1	224988612	224988662	224800910	224800960	15545	hg38	N/A	N/A	N/A	Enhatls17487	enhancer	MIXL1e+23-9				AATCCTTGCTGGAAGACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54476131045986809					CNIH3	chr1	224616316	224740554	54220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15927
enhrx-15926	chr1	224888922	224888972	224701220	224701270	15546	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-1				GAGGCGAGGTTAGCTAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55928482767900878					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888698	224888748	224700996	224701046	15547	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-10				CTTCTGGGCAGTGAAGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66636909661519617					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888833	224888883	224701131	224701181	15548	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-11				AGCTTCTGGAGAGGCCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2659033730672844					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888864	224888914	224701162	224701212	15549	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-12				ACTGCTATGCAGAGAGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40513786170148308					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889152	224889202	224701450	224701500	15550	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-13				CTCTCTCTGCACCCTTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.167891730779204					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888749	224888799	224701047	224701097	15551	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-14				ACTTCCTTCAGCCCCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32639693949759518					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889079	224889129	224701377	224701427	15552	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-15				ATCTGTAGAGGGCCACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74673285068028483					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889130	224889180	224701428	224701478	15553	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-16				GCTTGCCCCTCCACCATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0785331061312631					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888908	224888958	224701206	224701256	15554	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-17				TTTTTTTGCTGGAGGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068453114549483454					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889199	224889249	224701497	224701547	15555	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-18				ATTAGATGACAACATGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.005356923794273					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888991	224889041	224701289	224701339	15556	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-19				GTTGTTAAGCCACTGAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22747097424510351					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888847	224888897	224701145	224701195	15557	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-2				AGCAGTGTGACACCCCCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1534253854681954					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889249	224889299	224701547	224701597	15558	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-20				CCTAACACCATCACATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1738447802245642					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889164	224889214	224701462	224701512	15559	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-21				TGGGATTAGTGTCCTGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40614157067627388					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889051	224889101	224701349	224701399	15560	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-22				ATTGTCTGGCACCTTAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0040653827730797766					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889234	224889284	224701532	224701582	15561	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-23				GTGTTAGGAAGTGGGGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67933595377862332					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889097	224889147	224701395	224701445	15562	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-24				AAGACAGCTGTCTATGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027220223954351839					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889117	224889167	224701415	224701465	15563	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-25				CTTCTTGCTGCAGCCTTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11917376164402731					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889222	224889272	224701520	224701570	15564	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-26				GGGGTCTCTGGGAGTTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094583620248149744					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889016	224889066	224701314	224701364	15565	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-27				AAATGTATCTCTCACAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087631869250650321					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889184	224889234	224701482	224701532	15566	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-28				GAGGGTGGAGCCCTCGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70955404323878624					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889040	224889090	224701338	224701388	15567	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-29				GGCTGGGAAGTCCAAGATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60454848100292136					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888812	224888862	224701110	224701160	15568	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-3				CTTATGCATGCCATGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51500565142962285					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888897	224888947	224701195	224701245	15569	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-30				TTCTTTTTTTTTTTTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.97958196493003					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888713	224888763	224701011	224701061	15570	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-4				GCTCTCAAGTGACAACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56263932065078115					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888785	224888835	224701083	224701133	15571	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-5				GACCACCCATGGTGCTATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02334178807861689					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888940	224888990	224701238	224701288	15572	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-6				CATGGAAGATTGGTTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2025722365578477					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224889067	224889117	224701365	224701415	15573	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-7				AGACAATTCAGCATCTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26877456291164248					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888737	224888787	224701035	224701085	15574	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-8				GGACAGCATTGACCCATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39179188406011578					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15926	chr1	224888774	224888824	224701072	224701122	15575	hg38	N/A	N/A	N/A	Enhatls17484	enhancer	MIXL1e+24-9				TGAAGGGCCCTGACCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1516897356723802					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15925
enhrx-15924	chr1	224827323	224827373	224639621	224639671	15576	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-1				GACCCCTACCAGATGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1124104264691531					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827230	224827280	224639528	224639578	15577	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-10				TGTTCTGGCTCTAATTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49212494961254138					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827154	224827204	224639452	224639502	15578	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-11				TTCAAGGCTAGCTAGGTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27013722014313091					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827078	224827128	224639376	224639426	15579	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-12				GGGGCCCGCAGGCCCCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.177828002757664					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827185	224827235	224639483	224639533	15580	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-13				GAACAGCGTGATAAGCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36368276530159238					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827456	224827506	224639754	224639804	15581	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-14				GAATGTTAAGCTCTGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30902631785881041					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827139	224827189	224639437	224639487	15582	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-15				GTACTTGGAATTTTCCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27620250649206812					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827213	224827263	224639511	224639561	15583	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-16				ATAGCTTAAAACAATAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.573588171035794					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827301	224827351	224639599	224639649	15584	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-17				TGAGTTGTTTTTCAGAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16093649346860089					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827370	224827420	224639668	224639718	15585	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-18				CCTCAGATAAGGGGGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86641389441484451					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827125	224827175	224639423	224639473	15586	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-19				GAAAGTCTTGAGTTCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85924060777683053					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827170	224827220	224639468	224639518	15587	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-2				CGCTGTTCCTTTACTTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16281121061958179					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827262	224827312	224639560	224639610	15588	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-20				TGTTATCTTTAGTTTCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2259843209692329					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827416	224827466	224639714	224639764	15589	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-21				TGTTCTAAATTTCTTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26491409293897272					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827066	224827116	224639364	224639414	15590	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-3				TGTCTTGTGAGCCCTCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.108039205033771					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827089	224827139	224639387	224639437	15591	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-4				CTTGAGAAGGTGGGGCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069620950065075377					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827102	224827152	224639400	224639450	15592	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-5				CATTATTTTCAAGCTTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36935071076654158					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827352	224827402	224639650	224639700	15593	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-6				TGAGGTCTACCTGCCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39876810316180272					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827431	224827481	224639729	224639779	15594	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-7				TGATTTCCCTCCAGGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2642167372326184					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827245	224827295	224639543	224639593	15595	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-8				ACAGGGAACCAAACATGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39351972823258857					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-15924	chr1	224827339	224827389	224639637	224639687	15596	hg38	N/A	enh27580	N/A	Enhatls17482	enhancer	MIXL1e+25-9				AAAATGGAAAATGCCATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54960689173040322					CNIH3	chr1	224616316	224740554	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	15923
enhrx-16082	chr1	226391820	226391870	226204119	226204169	15597	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-1				GCACACATGCCTGTGTCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8899373913118662					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391674	226391724	226203973	226204023	15598	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-10				ATCACCCTAGTCCCTGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.927892558293687					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391468	226391518	226203767	226203817	15599	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-11				GGATGGGCCTGGTGATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9271590892289321					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391806	226391856	226204105	226204155	15600	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-12				GTCATGAGGGAGAGCATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6078382375172411					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391793	226391843	226204092	226204142	15601	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-13				GCATGGCTGGCCTGCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5645376198030989					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391724	226391774	226204023	226204073	15602	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-14				TCTGGCTGGAACAGACATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7919698524787622					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391779	226391829	226204078	226204128	15603	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-15				CTCTCTTGGTACTTATTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01524604281349313					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391842	226391892	226204141	226204191	15604	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-16				TGTTTTAAATAGATGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38001135377211681					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391662	226391712	226203961	226204011	15605	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-17				TGGTGTGCAAACCCCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1826354704609381					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391484	226391534	226203783	226203833	15606	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-18				GGCTCAGGCCTGGAGAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.999522282360247					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391499	226391549	226203798	226203848	15607	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-19				TCTCAGAGGAGAAAAGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.920028032065271					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391558	226391608	226203857	226203907	15608	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-2				GCTGCTATGTGAGGCGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5201258620716862					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391431	226391481	226203730	226203780	15609	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-20				CCTGTGCATTGCAGGACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85559691467493271					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391457	226391507	226203756	226203806	15610	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-21				GTGATTGCTGGGTGGGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.712674962931874					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391513	226391563	226203812	226203862	15611	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-3				AGTGGGGGATCTCTTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6608270639583189					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391616	226391666	226203915	226203965	15612	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-4				ACTGCATATCTTCAAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5370637208549089					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391706	226391756	226204005	226204055	15613	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-5				GGTGTCACACAGCAGGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6639886004802831					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391528	226391578	226203827	226203877	15614	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-6				CCCCCACTGTTGAGAACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1929489286295132					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391763	226391813	226204062	226204112	15615	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-7				TATAAGGTCCTTCTTACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.124809566043127					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391685	226391735	226203984	226204034	15616	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-8				GACTAGGGTGATGGATTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9875117381658671					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226391643	226391693	226203942	226203992	15617	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+3-9				ACCACATTTTCCTGGGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87761587806621089					ACBD3	chr1	226144678	226186741	14464				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384789	226384839	226197088	226197138	15618	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-1				GAACGAGTCCTTGGAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85910019447595443					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226385066	226385116	226197365	226197415	15619	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-10				CAGCACAGCTGACTCCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92090574921382984					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384763	226384813	226197062	226197112	15620	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-11				AAGACGTGAAAGGTTGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3609132523565734					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384959	226385009	226197258	226197308	15621	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-12				AGCTCTGCAGCTCCCAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.2762933285240923					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384981	226385031	226197280	226197330	15622	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-13				TGGGGCAAACCTGGGGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0848690052960961					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384844	226384894	226197143	226197193	15623	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-14				GGCACCTCGGCCCCACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.086762831308475674					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384903	226384953	226197202	226197252	15624	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-15				TATGGGGCTGGCAGAGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45266890549141259					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226385052	226385102	226197351	226197401	15625	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-16				GATCAATAAAAAAGCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2499869750472184					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384996	226385046	226197295	226197345	15626	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-17				GCTCTGGGCAGGTCTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0884094933278781					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384936	226384986	226197235	226197285	15627	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-18				CTGGGAAGAAGAGGTCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.02924622897256					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384917	226384967	226197216	226197266	15628	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-19				AGGGATGGGATGGGGCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11118555571046961					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384822	226384872	226197121	226197171	15629	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-2				GAGACCGAGGCTTAAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19396012842254159					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384867	226384917	226197166	226197216	15630	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-3				TGGGGCAGCGCTACCGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54828660979425936					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384855	226384905	226197154	226197204	15631	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-4				ACCGTCTCCGGCCAGCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60010110571118092					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384749	226384799	226197048	226197098	15632	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-5				TCACGTCTTCTTGCTGTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.564390452365477					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384891	226384941	226197190	226197240	15633	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-6				CCGCTCAGTGCTTATGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.587490534747525					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384809	226384859	226197108	226197158	15634	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-7				TTCAAAAGATGCTGAGACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.172753634538744					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226385014	226385064	226197313	226197363	15635	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-8				ATTCTCCACAGTATACTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92295563630060662					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16082	chr1	226384947	226384997	226197246	226197296	15636	hg38	N/A	enh956	N/A	Enhatls17655	enhancer	MIXL1e+4-9				AGGTCGCTGAGGCCCCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044230643039644107					ACBD3	chr1	226144678	226186741	8324				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16081
enhrx-16074	chr1	226309750	226309800	226122049	226122099	15637	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-1				GGACTGCGGTCGCGGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55044931011584153					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309823	226309873	226122122	226122172	15638	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-10				GCCGCCTCACCAGTCTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39450562177802367					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309797	226309847	226122096	226122146	15639	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-11				AAACCGCGGGACGGCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26852340561806609					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309771	226309821	226122070	226122120	15640	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-12				TCTTCAGTGCGGCTCTCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2137379510780078					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309884	226309934	226122183	226122233	15641	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-13				CGCAGCCAGGACTGCACTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40419529990362463					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309993	226310043	226122292	226122342	15642	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-14				CTCGCGCGCCTTCCAGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0090141057321529074					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309306	226309356	226121605	226121655	15643	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-15				TGCTGTCACCCCGCGGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3923255070608197					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309516	226309566	226121815	226121865	15644	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-16				GTTACACCTGGCCTCTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14143905557501529					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309453	226309503	226121752	226121802	15645	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-17				GCGCTTCCTTCGCTACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.213558927185077					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309810	226309860	226122109	226122159	15646	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-18				GTGAGGCGGCGGGAAACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26426182809089832					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309928	226309978	226122227	226122277	15647	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-19				CCGGGCGGCTCCACGCGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.129411028146856					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309154	226309204	226121453	226121503	15648	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-2				CGCCGGCCAGAGAACCGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1240494850339615					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309119	226309169	226121418	226121468	15649	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-20				GACGGCTAGCACCTGCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5207534372120417					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309916	226309966	226122215	226122265	15650	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-21				GAGCCGCCCGGGACGCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.046513837559277127					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309504	226309554	226121803	226121853	15651	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-22				GTGACACCAGTAGTTACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75041763369225256					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309375	226309425	226121674	226121724	15652	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-23				GAGCGTCGGGGCCTGCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24182234647193709					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309428	226309478	226121727	226121777	15653	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-24				TTTGGGACGACCTGGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40169004786532519					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226310005	226310055	226122304	226122354	15654	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-25				TGCGGCCTCTGGCCTTCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.552548064037715					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309322	226309372	226121621	226121671	15655	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-26				GACAGCAGCCGGGCGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37864067650506378					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309552	226309602	226121851	226121901	15656	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-27				TCGCGCCCCCAGCGCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30311421603710009					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309783	226309833	226122082	226122132	15657	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-28				CGCACTGAAGAGCCCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070389182079021548					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309351	226309401	226121650	226121700	15658	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-29				GCGCTCCCGCCTGCTGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1229370942180229					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309175	226309225	226121474	226121524	15659	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-3				CGGCCTTGTTGGTTCCGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37278517919184923					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309337	226309387	226121636	226121686	15660	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-30				TGCGCGCGGCGGCCACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47184330502358068					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309189	226309239	226121488	226121538	15661	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-31				GCGGGGTCCCTTTCCCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43658411119676421					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309577	226309627	226121876	226121926	15662	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-32				CGGGCGGGGAGCGGAAACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8054242681383964					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309976	226310026	226122275	226122325	15663	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-33				CGCGAGCCGGCGGCCCCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.29951124376125					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309736	226309786	226122035	226122085	15664	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-34				GAACAAAGGGGCGCGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12987882467371581					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309218	226309268	226121517	226121567	15665	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-35				TGGCGCTGCTGGCGGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41150096087897042					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309869	226309919	226122168	226122218	15666	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-36				TGGCTGCGTTGTGGGAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17485176162061239					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309411	226309461	226121710	226121760	15667	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-37				GGCCGGGGACCCTGCACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.270599644383895					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309362	226309412	226121661	226121711	15668	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-38				AGGCGGGAGCGCGGAGCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04534566464262163					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309259	226309309	226121558	226121608	15669	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-39				AGCGGCGGGCCCGCCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4273702324032009					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309527	226309577	226121826	226121876	15670	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-4				GCGCTGCTCGCCCGATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53120535527556068					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309235	226309285	226121534	226121584	15671	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-40				GCGCCAGGCCCCCCCCCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18728026192673439					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309275	226309325	226121574	226121624	15672	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-41				CGCCGCTGACCTCCCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55746054419254054					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309637	226309687	226121936	226121986	15673	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-42				CTGGCGGCCGCGCCCCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1231164657618891					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309466	226309516	226121765	226121815	15674	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-43				TACAAAAAGGAAGCACATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58221928204136686					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309667	226309717	226121966	226122016	15675	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-44				AGGTCTCCTCACCTCCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42236087879905632					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309854	226309904	226122153	226122203	15676	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-45				AGCCGCGGCCACGCCAGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83653635144595451					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309290	226309340	226121589	226121639	15677	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-46				AGCGCGGGACCCAGGCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44710356822761937					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309685	226309735	226121984	226122034	15678	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-47				GACCTCAGCCCCGGACGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46113686709988422					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309625	226309675	226121924	226121974	15679	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-48				CGCCTGGGGAGCCCGCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4872467904369591					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309656	226309706	226121955	226122005	15680	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-49				CCAGACCCCGCCCGGCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.283557434393241					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309140	226309190	226121439	226121489	15681	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-5				GGTCACACGGCGACCCAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0810494155735334					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309965	226310015	226122264	226122314	15682	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-50				GGCCCCGAGAGGCCGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.132157598463473					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309835	226309885	226122134	226122184	15683	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-51				GTCTCGGGCGGGAGGGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4961534200170714					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309699	226309749	226121998	226122048	15684	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-52				ACGCCGAGGCCCCGCCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59141477215099814					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309247	226309297	226121546	226121596	15685	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-53				GCCACCCCCGGCCCCTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82942761529468312					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309563	226309613	226121862	226121912	15686	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-54				GCGCTGAGCAGGGGCGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99544445142029236					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309953	226310003	226122252	226122302	15687	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-55				GCCCCCGCGCCTCCCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6342531651056964					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309388	226309438	226121687	226121737	15688	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-6				TGCAACCGGGCGGGGATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64620612810177425					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309602	226309652	226121901	226121951	15689	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-7				GTGGTTGTTGCCGCGCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31339489400353432					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309203	226309253	226121502	226121552	15690	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-8				GGACCCCGCAATCGTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92652794098801949					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226309713	226309763	226122012	226122062	15691	hg38	N/A	enh953	N/A	Enhatls17647	enhancer	MIXL1e+5-9				CGGGGGGTGCATCGCCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36215943081115609					ACBD3	chr1	226144678	226186741	17073				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298878	226298928	226111177	226111227	15692	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-1				ATACCGATGGAACTCTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3156146671076957					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298732	226298782	226111031	226111081	15693	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-10				GCAGCACCGTGACCTCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26377216329000558					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298859	226298909	226111158	226111208	15694	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-11				GTATCTTGAGTTCCCCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51062203934661021					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298846	226298896	226111145	226111195	15695	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-12				CAACAGAATCCCCCCACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33565989659610118					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298330	226298380	226110629	226110679	15696	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-13				GCGTGGCTCCGGAAGCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70786240115270815					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298319	226298369	226110618	226110668	15697	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-14				GAAGCAGGTCGGCTTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.646588458243286					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298388	226298438	226110687	226110737	15698	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-15				AGAGCGAGGGCGCCAGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48008981996419958					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298771	226298821	226111070	226111120	15699	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-16				GCAAGACATGTCAGAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2029734779585807					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298771	226298821	226111070	226111120	15700	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-16				GCAAGACATGTCAGAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2029734779585807					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298673	226298723	226110972	226111022	15701	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-17				ATGATGACAATCTTGCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49127182631079408					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298745	226298795	226111044	226111094	15702	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-18				ACGGTGCTGCTGCCCAACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25860486354968					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298443	226298493	226110742	226110792	15703	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-19				TGGTGGCTAAGCAGCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5301815709016765					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298757	226298807	226111056	226111106	15704	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-2				AAATCCGGGCTCCCGCCGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01039462100622094					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298403	226298453	226110702	226110752	15705	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-20				GCTCGGGGCTTCCCGGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14487782496221391					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298508	226298558	226110807	226110857	15706	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-21				GGGCGGCTCTAGGGGCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.043547170045553					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298508	226298558	226110807	226110857	15707	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-21				GGGCGGCTCTAGGGGCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.043547170045553					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298788	226298838	226111087	226111137	15708	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-22				TCTTGCAAGAAAGAGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048781757124289393					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298788	226298838	226111087	226111137	15709	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-22				TCTTGCAAGAAAGAGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048781757124289393					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298698	226298748	226110997	226111047	15710	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-23				CGGCTTCCGCTTCTGTAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061193241790313178					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298606	226298656	226110905	226110955	15711	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-24				GCTCCCTCCGGCTGTGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31386216996947752					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298482	226298532	226110781	226110831	15712	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-25				CTTCCTCCGCCCGCGCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066568662981761118					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298805	226298855	226111104	226111154	15713	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-26				TATAATTGCATTTGCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88021904019438091					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298805	226298855	226111104	226111154	15714	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-26				TATAATTGCATTTGCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88021904019438091					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298658	226298708	226110957	226111007	15715	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-27				GGCTACCCCTCACCACCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20142296471974239					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298471	226298521	226110770	226110820	15716	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-28				CGCGCCGCGCGGGCCACCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34974480676868358					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298618	226298668	226110917	226110967	15717	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-29				GTTTCTGCTGCAGCTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1853998458050122					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298545	226298595	226110844	226110894	15718	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-3				TCCCCGGCTACCCGAGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31678146658813638					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298816	226298866	226111115	226111165	15719	hg38	N/A	enh952	fant5041	Enhatls17647	enhancer	MIXL1e+6-30				AATGCAATTATATTCTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0460615590252					ACBD3	chr1	226144678	226186741	33223				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298584	226298634	226110883	226110933	15720	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-31				GAGCAAGGTCAGCAAGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0628562740293435					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298559	226298609	226110858	226110908	15721	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-32				AGCCGGGGATGGCGGGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38847062403122029					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298415	226298465	226110714	226110764	15722	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-33				TGCCTCCTCCGCCCCCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2462087418063926					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298429	226298479	226110728	226110778	15723	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-34				GAGGAGGCAGCAGCCCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.272254382425309					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298303	226298353	226110602	226110652	15724	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-35				AGAGGCGCGCGGATCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52529865228448791					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298526	226298576	226110825	226110875	15725	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-4				GCGGTCGCGGACGACTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94918743906368519					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298526	226298576	226110825	226110875	15726	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-4				GCGGTCGCGGACGACTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94918743906368519					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298458	226298508	226110757	226110807	15727	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-5				AGCCACCAGATGTCCGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35866292521514459					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298718	226298768	226111017	226111067	15728	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-6				TCTAGCAGGCTATTTAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14487192649129391					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298345	226298395	226110644	226110694	15729	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-7				AGCCACGCGCGGGGCGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.145067808678819					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298374	226298424	226110673	226110723	15730	hg38	N/A	enh952	fant5040	Enhatls17647	enhancer	MIXL1e+6-8				CGGATGCTGCGACCAGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43387573610643249					ACBD3	chr1	226144678	226186741	33847				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226298644	226298694	226110943	226110993	15731	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+6-9				GGGGTAGCCGAGCTTTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.092484242055288					ACBD3	chr1	226144678	226186741	33567				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297319	226297369	226109618	226109668	15732	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-1				CAGCTCGACCGCATACCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.148410580158942					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297409	226297459	226109708	226109758	15733	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-10				CGCATGGGGAAAGCGGCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77044206241989988					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297691	226297741	226109990	226110040	15734	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-11				CGCGCGTCACTCGCGGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19269879754827629					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297527	226297577	226109826	226109876	15735	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-12				TCTTCGATATTCGCATCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038504375966132258					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297902	226297952	226110201	226110251	15736	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-13				GAGCAGTGCGGAGAGCGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1329666566023886					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297649	226297699	226109948	226109998	15737	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-14				GCCAGTTGCGTCGGGAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77087983749562283					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297794	226297844	226110093	226110143	15738	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-15				CGCGACCACCCGGGGCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27383789936968189					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297303	226297353	226109602	226109652	15739	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-16				ATGGGGTATGCGGTCTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043487898081989752					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297829	226297879	226110128	226110178	15740	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-17				GCCCAAGCCCTGCTTAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65048904729567336					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297467	226297517	226109766	226109816	15741	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-18				TGCTGCGAGGAGAGGCGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.316408300226807					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297366	226297416	226109665	226109715	15742	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-19				AACTGTGCTATGGGCAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2225635349017353					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297562	226297612	226109861	226109911	15743	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-2				AAATCGCATTTCTAAACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47830328597328181					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297355	226297405	226109654	226109704	15744	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-20				CATAGCACAGTTCCAAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0746329244720237					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297343	226297393	226109642	226109692	15745	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-21				GCACTGACACTTCCCTACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2410472416427096					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297862	226297912	226110161	226110211	15746	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-22				ACGCACCGGGCGGAGGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.41719388397406					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297269	226297319	226109568	226109618	15747	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-23				GACGCCCCAGCTCAGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066168555317747152					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297674	226297724	226109973	226110023	15748	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-24				CGCGCGCGCCTCCCAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47095188634659768					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297619	226297669	226109918	226109968	15749	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-25				GTCCCGGCGGAGGAGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9288025718569082					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297812	226297862	226110111	226110161	15750	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-26				TTGGGCGCGCGCGGGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.06443903112047232					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297424	226297474	226109723	226109773	15751	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-27				GCGGTCGGAGTGGGGCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62811329592522647					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297746	226297796	226110045	226110095	15752	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-28				TGCTCCGGGGAGCGCGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4759323540189762					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297580	226297630	226109879	226109929	15753	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-29				CCAGGTGGAGATTTGTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.639152743768121					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297394	226297444	226109693	226109743	15754	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-3				GCGCTGAATCCGTGGCGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78374924052368466					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297454	226297504	226109753	226109803	15755	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-30				CCTCCTCCTGAGCTGCTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17533513343760551					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297258	226297308	226109557	226109607	15756	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-31				TCAGGCTTCAGGCTTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26272605107575547					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297734	226297784	226110033	226110083	15757	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-32				TCCCCGGAGCAGCCCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86078184268948255					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297765	226297815	226110064	226110114	15758	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-33				GCGGGGGCGTGCGCGTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.374120453397398					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297919	226297969	226110218	226110268	15759	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-34				CGTGGGCCGCGGCGGAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25089902427176758					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297715	226297765	226110014	226110064	15760	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-35				TGGCTGGCCGGGCGCGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8939687435317889					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297663	226297713	226109962	226110012	15761	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-36				GAGAGGAGGAGCCGCAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19309236696369761					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297442	226297492	226109741	226109791	15762	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-37				TCAGGAGGAGGTGACAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04455001390113749					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297500	226297550	226109799	226109849	15763	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-38				CACAGCTGCCTCCCTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17008001086849839					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297704	226297754	226110003	226110053	15764	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-39				CGGGCAGGGGCTGGCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073558397643302686					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297286	226297336	226109585	226109635	15765	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-4				GGCGTCCGGACCGCTCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43903245967582571					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297886	226297936	226110185	226110235	15766	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-5				ACTGCTCTTGGAACGTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36346486371125292					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297516	226297566	226109815	226109865	15767	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-6				CGCATCTCCCGGGATTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69696643605089081					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297605	226297655	226109904	226109954	15768	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-7				CGCCGGGACATCTGTCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21927223621685021					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297783	226297833	226110082	226110132	15769	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-8				CGGGTGGTCGCGCGCACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0067407136912842639					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226297875	226297925	226110174	226110224	15770	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+7-9				AACGTCCCGCGGGACGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18445692321722609					H3-3A	chr1	226061850	226072019	29143				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285522	226285572	226097821	226097871	15771	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-1				GTACATTCACTAAGGCTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082051549240962057					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285707	226285757	226098006	226098056	15772	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-10				AGGGGAATGTGTATTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089676139923224					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285799	226285849	226098098	226098148	15773	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-11				CATAGCCTCATTCGTAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1221872317047885					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285633	226285683	226097932	226097982	15774	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-12				ATTATCAGCTTATCTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097671500135833672					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285633	226285683	226097932	226097982	15775	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-12				ATTATCAGCTTATCTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097671500135833672					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285841	226285891	226098140	226098190	15776	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-13				TTTTGTTCCCAAACAGATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.426128276752865					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285622	226285672	226097921	226097971	15777	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-14				ATCTTCACAGGGACAGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65359293156198539					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285484	226285534	226097783	226097833	15778	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-15				AGGGTAGACAATGAGGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19005628047833939					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285646	226285696	226097945	226097995	15779	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-16				AGCTGATAATTGACATTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25846336762545841					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285646	226285696	226097945	226097995	15780	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-16				AGCTGATAATTGACATTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25846336762545841					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285384	226285434	226097683	226097733	15781	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-17				TCACAAATAGCTGGGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1843485144291681					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285432	226285482	226097731	226097781	15782	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-18				TACTGCAACCTCCACCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3051701930459654					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285457	226285507	226097756	226097806	15783	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-19				GGAGCGCAGTGGAGCGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5245561722606809					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285468	226285518	226097767	226097817	15784	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-2				CTACCCTTCTAGGAGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24730672146742891					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285415	226285465	226097714	226097764	15785	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-20				CATGAGAATCACTTGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2542362749364779					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285575	226285625	226097874	226097924	15786	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-3				ATTATGCAAAGTCTTGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1476339737453361					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285723	226285773	226098022	226098072	15787	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-4				TGAAAGGTTTAGGGGCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.026767872162909351					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285773	226285823	226098072	226098122	15788	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-5				TATGTAGCCTTCTATTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46990174150901792					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285544	226285594	226097843	226097893	15789	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-6				TCCTCTGTTTCACATGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.347273670423729					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285689	226285739	226097988	226098038	15790	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-7				ATTTTAGAACTAGCTTATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9411346731736723					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285497	226285547	226097796	226097846	15791	hg38	N/A	enh952	N/A	Enhatls17647	enhancer	MIXL1e+8-8				AGGCAAATGGATACAATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44405256432355261					H3-3A	chr1	226061850	226072019	23946				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16074	chr1	226285746	226285796	226098045	226098095	15792	hg38	N/A	enh952	fant5038	Enhatls17647	enhancer	MIXL1e+8-9				GAATTTCCTTGTGAACAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18397150483322949					H3-3A	chr1	226061850	226072019	25957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16073
enhrx-16070	chr1	226190459	226190509	226002758	226002808	15793	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-1				TAAGGCAACACTTGCCAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.159204744265108					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190491	226190541	226002790	226002840	15794	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-10				GACCTCATTGTCCCTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55433825921202362					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190491	226190541	226002790	226002840	15795	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-10				GACCTCATTGTCCCTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55433825921202362					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190650	226190700	226002949	226002999	15796	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-11				CTTATTGGATGGAAGAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55556856782851649					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190748	226190798	226003047	226003097	15797	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-12				AGAAAAGAACACTAGGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0705566454693849					SDE2	chr1	225982701	225999343	3697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190606	226190656	226002905	226002955	15798	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-13				TTCCCTGACAGCCAGCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.071561664949524137					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190665	226190715	226002964	226003014	15799	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-14				AAAACAGGACAATGGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.035587625007073					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190724	226190774	226003023	226003073	15800	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-15				CACTGGAAAGGAGCATGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.187181993401599					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190724	226190774	226003023	226003073	15801	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-15				CACTGGAAAGGAGCATGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.187181993401599					SDE2	chr1	225982701	225999343	3697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190432	226190482	226002731	226002781	15802	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-16				TTATGGCATTTTTGCATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.161452292068602					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190772	226190822	226003071	226003121	15803	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-17				GCAGAGCAGAGATAAAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.099532347812666275					SDE2	chr1	225982701	225999343	3697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190565	226190615	226002864	226002914	15804	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-18				CGGGTGGTGGATGGTGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73955725802875982					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190684	226190734	226002983	226003033	15805	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-19				GTGGAGTTGAGAGGCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74151971216842616					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190552	226190602	226002851	226002901	15806	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-2				GTGTAGTCCACAGCGGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1828871893778298					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190445	226190495	226002744	226002794	15807	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-3				AATGCCATAAACCCCCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55550532549673692					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190595	226190645	226002894	226002944	15808	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-4				TGAAGCAAGTCCCAAGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2338641138143765					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190635	226190685	226002934	226002984	15809	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-5				GCCCCGCCCTCCTTCCTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1061960081723657					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190505	226190555	226002804	226002854	15810	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-6				AATGAGGTCAGCTCCTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.119017705171281					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190505	226190555	226002804	226002854	15811	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-6				AATGAGGTCAGCTCCTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.119017705171281					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190707	226190757	226003006	226003056	15812	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-7				GTTGTGTTCAGCACTGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24823311811214549					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190707	226190757	226003006	226003056	15813	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-7				GTTGTGTTCAGCACTGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24823311811214549					SDE2	chr1	225982701	225999343	3697				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190480	226190530	226002779	226002829	15814	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-8				TATAGATGGCTCCAGCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66874997386261847					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190520	226190570	226002819	226002869	15815	hg38	N/A	enh12727	N/A	N/A	enhancer	MIXL1e+9-9				TAGGATGGAAAAACAGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.538249474886115					SDE2	chr1	225982701	225999343	3262				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-16070	chr1	226190520	226190570	226002819	226002869	15816	hg38	N/A	enh12727	fant5033	N/A	enhancer	MIXL1e+9-9				TAGGATGGAAAAACAGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.538249474886115					SDE2	chr1	225982701	225999343	3491				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	16069
enhrx-35558	chr12	7959647	7959697	7807051	7807101	15817	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-1				GTGCCACGGTAGACCACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40828469102313159					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959591	7959641	7806995	7807045	15818	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-10				CTTAATGGCTTTGCCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25284164459818842					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959661	7959711	7807065	7807115	15819	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-11				GATTGGTGAGCCCAGTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30015958701555839					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959727	7959777	7807131	7807181	15820	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-12				CATGTTCAGGGACAAGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.288517301996209					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959788	7959838	7807192	7807242	15821	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-13				TAGAAATCAATTGAGAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36195909537416537					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959484	7959534	7806888	7806938	15822	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-14				TCATATTTCAAAAATGTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0083464848140513779					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959634	7959684	7807038	7807088	15823	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-2				AGAGTCACACCCCCCTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47748456913631038					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959686	7959736	7807090	7807140	15824	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-3				CCAACTGTTTTACAATGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17286728998845621					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959578	7959628	7806982	7807032	15825	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-4				AGATTAGACTGTCCCTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39002853798337689					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959533	7959583	7806937	7806987	15826	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-5				AGTATTCTAGCATGTCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.435413416861509					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959518	7959568	7806922	7806972	15827	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-6				GTACTTGTACTGATACCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26981048481846459					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959714	7959764	7807118	7807168	15828	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-7				TCCTTAACCATCACATGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75937658496927873					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959606	7959656	7807010	7807060	15829	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-8				TGAGCTTAACATTGACTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091089139861733379					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35558	chr12	7959753	7959803	7807157	7807207	15830	hg38	N/A	N/A	N/A	Enhatls38597	enhancer	NANOGe-1-9				TGTAATTGAAGAATATGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019504435041496172					SLC2A14	chr12	7812511	7891148	8				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	868
enhrx-35605	chr12	8298925	8298975	8146329	8146379	15831	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-1				AACCGCCCAGTCTCGCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38773930371216331					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298713	8298763	8146117	8146167	15832	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-10				ATGGGAAAGGGCTAAAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0835400752867861					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298669	8298719	8146073	8146123	15833	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-11				CTCACTGGAATTCCCAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034064192127062652					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298837	8298887	8146241	8146291	15834	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-12				CTGGAGACTGCCTAAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24941052754408979					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298612	8298662	8146016	8146066	15835	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-13				CTGCTCAGATGGGTGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08044574542109055					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298684	8298734	8146088	8146138	15836	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-14				AGACAGATCTCTTGCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51709230365067471					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298656	8298706	8146060	8146110	15837	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-15				GTTTTTGCATACTCCAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1212828151134713					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298899	8298949	8146303	8146353	15838	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-16				GGCAGAGGAAAACGGCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34981951194222322					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298818	8298868	8146222	8146272	15839	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-17				TCCCGGCCAGTGCAGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12795630512413331					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298914	8298964	8146318	8146368	15840	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-18				CTCGCTGGGAGGGGTGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.55531167760156					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298589	8298639	8145993	8146043	15841	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-19				AGAGCTGTGCAGACTCACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42546608363524629					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298761	8298811	8146165	8146215	15842	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-2				TCCGCGGTTTCCATGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38648991350525119					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298800	8298850	8146204	8146254	15843	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-20				CGGGAGGGATTCCAAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3418853751129371					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298632	8298682	8146036	8146086	15844	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-21				TGGAGCAGGCACTGAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43157854654163241					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298884	8298934	8146288	8146338	15845	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-22				GCCATCACTGCGGCTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33062929607220087					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298730	8298780	8146134	8146184	15846	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-23				AGCGAGGCTGCTTGGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42826357629362988					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298572	8298622	8145976	8146026	15847	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-24				AGCTCTGTGTTTGCGACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1064886467954842					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298789	8298839	8146193	8146243	15848	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-25				CAAGCTAAAACCCACTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40841370044568842					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8299001	8299051	8146405	8146455	15849	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-26				TCCCGCTTAACGAAGCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0545143719183408					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298547	8298597	8145951	8146001	15850	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-27				CTGGTGGCATGGGCTCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45464932626107463					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298558	8298608	8145962	8146012	15851	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-28				GACCCAAGGCCCTGGTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22702802102416639					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298777	8298827	8146181	8146231	15852	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-3				GTTTTAGCTTGTGACTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.051704711786985727					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298848	8298898	8146252	8146302	15853	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-4				CTAAGAAGACGGAGTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14827381474335119					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298967	8299017	8146371	8146421	15854	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-5				TACAGCGCAGCACAGTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1503885687487316					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298601	8298651	8146005	8146055	15855	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-6				ACTCACGGTGGCTGCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1170009430142939					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298978	8299028	8146382	8146432	15856	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-7				ACAGTGACTAGGACAGTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38728710631232982					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298746	8298796	8146150	8146200	15857	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-8				AGAATAGGGCCTGCTGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24208740199112369					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35605	chr12	8298695	8298745	8146099	8146149	15858	hg38	N/A	enh14509	N/A	Enhatls38645	enhancer	NANOGe-10-9				AGAGATCTGTCTACTCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14652392137089629					CLEC4A	chr12	8123616	8138607	5290				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	915
enhrx-35620	chr12	8470362	8470412	8317766	8317816	15859	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-1				AATTGATAACGCCCAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71354386418648652					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469930	8469980	8317334	8317384	15860	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-10				GATGAAGGGTACAAGTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36382827754869029					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470394	8470444	8317798	8317848	15861	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-11				GAGCAGTATCTGCAGTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27372182194768713					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469919	8469969	8317323	8317373	15862	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-12				CAAGTTGAAGGGGTTTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29864617584325143					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470150	8470200	8317554	8317604	15863	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-13				GTTAGCCATTTCTTAGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044802588647542843					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470025	8470075	8317429	8317479	15864	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-14				AACATCATCTTCACTACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18350942100419651					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470254	8470304	8317658	8317708	15865	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-15				TAAAACAATTTTACAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.098700139262176					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470134	8470184	8317538	8317588	15866	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-16				GAGTCTGTTTATTTAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17334528114270609					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470350	8470400	8317754	8317804	15867	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-17				AGGTGATAGACGCCAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86999169375082042					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470309	8470359	8317713	8317763	15868	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-18				AAGTAAACAGTTCTAGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40869086530234089					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470167	8470217	8317571	8317621	15869	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-19				GCTAACGTTTAAAGTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1007559256504407					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470466	8470516	8317870	8317920	15870	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-2				GCTTGTACAAGTTAAGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4762886895991415					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470224	8470274	8317628	8317678	15871	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-20				TGGTTTAGAAAGGGGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1016830199871466					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470555	8470605	8317959	8318009	15872	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-21				ATTCAGGTGGAAATAAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5147320218428143					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470285	8470335	8317689	8317739	15873	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-23				TTAAAAGGAAAAACTGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.804343741424268					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470542	8470592	8317946	8317996	15874	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-24				TAAGGGAGAGTCAATTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28732065909812038					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470180	8470230	8317584	8317634	15875	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-25				GTTCTCTCGGCCTCGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30776876079929749					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470483	8470533	8317887	8317937	15876	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-29				CACTGGCAGCCCCTTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.95829548906283					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470076	8470126	8317480	8317530	15877	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-3				GCTGGATGTGTTGTACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28662633811526061					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470524	8470574	8317928	8317978	15878	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-30				CTGTCTGGCTCTCTTAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71628674363684186					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470512	8470562	8317916	8317966	15879	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-31				GAGCCAGACAGACTCCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.508498976702153					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470113	8470163	8317517	8317567	15880	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-32				TCTTAATTCGTCTCAAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55327651166633862					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470204	8470254	8317608	8317658	15881	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-33				CTAGATTTTCTTTTATACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.552857223920288					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469998	8470048	8317402	8317452	15882	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-4				GAAATATCCTTAAATGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33494593441905779					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469980	8470030	8317384	8317434	15883	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-5				ATGGGGATGAGTTCCTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82125935863367316					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470058	8470108	8317462	8317512	15884	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-6				AGAGTGGATTACGTGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28705805109663018					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470043	8470093	8317447	8317497	15885	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-7				TCCACTCTAAAATGCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072288795269952771					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469964	8470014	8317368	8317418	15886	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-8				TAGCTCAACATGTATGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48344062473321381					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8469945	8469995	8317349	8317399	15887	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11-9				GCTAAGTACTTTGCTGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20041698060035021					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470270	8470320	8317674	8317724	15888	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11/-12/SOX2e-24				AAGTAGGCAAAAAAGTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8974851930136161					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470500	8470550	8317904	8317954	15889	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11/SOX2e-21				CTCCATCTTGGCTCTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.6103298812115918					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470330	8470380	8317734	8317784	15890	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11/SOX2e-21/-24				GGGGCTTTAAGACTATTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.84113857198506					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8470428	8470478	8317832	8317882	15891	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-11/SOX2e-24				TTATCAGTTAATTGCATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45544857144135431					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477557	8477607	8324961	8325011	15892	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-1				GAGCACTCCATTGAAGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43704024567709188					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477248	8477298	8324652	8324702	15893	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-10				GGGCTTTAGGCATTATCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31685553722787307					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477396	8477446	8324800	8324850	15894	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-11				GAGCTAGACAGACTTTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3800163773255561					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477487	8477537	8324891	8324941	15895	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-12				GAACAAAGTTAATAAAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0231304537798378					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477026	8477076	8324430	8324480	15896	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-13				TTTAGCTGGCGGCCAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37621071704720388					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477278	8477328	8324682	8324732	15897	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-14				GAGCAATATCCGCAGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34528498263625229					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477423	8477473	8324827	8324877	15898	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-15				AGCTAAAAGAAAGTCAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35075392340030948					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477384	8477434	8324788	8324838	15899	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-16				CTTTATCTTGGCTTTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88594604519049491					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477455	8477505	8324859	8324909	15900	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-17				GGCTAAGTGATTAAAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.914217615320286					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477228	8477278	8324632	8324682	15901	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-18				ATTACAAAGTGATAGACGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91962811462363458					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8476996	8477046	8324400	8324450	15902	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-19				ACTTAATTCATGTCAAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25932215919563611					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477505	8477555	8324909	8324959	15903	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-2				CAAGGTTAGGCATTACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81749852360238584					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477261	8477311	8324665	8324715	15904	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-20				TATCAATCGGACAAATTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1491149530368944					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477138	8477188	8324542	8324592	15905	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-21				GAATTTTACAGAAGTAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41920245828233738					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477434	8477484	8324838	8324888	15906	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-23				AGTCAATTCAGGTAGAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.176873588019107					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477061	8477111	8324465	8324515	15907	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-24				GTTCTCTTGGCCCCGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1333800038415269					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477073	8477123	8324477	8324527	15908	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-25				AGAAAATCTAGCCCCTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20710062672116561					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477169	8477219	8324573	8324623	15909	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-27				TTAAAAGGATAAATTGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.6592999822762309					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477302	8477352	8324706	8324756	15910	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-28				AATTAACTGATAAGATACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81611063358761371					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477579	8477629	8324983	8325033	15911	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-3				ATGGTTCAAGTTATCAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2328892817105474					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477012	8477062	8324416	8324466	15912	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-4				ATTAAGTCTGTTTATTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22528462037044389					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477533	8477583	8324937	8324987	15913	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-5				CAAACACTGTGCTGAATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.069408449840509687					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477598	8477648	8325002	8325052	15914	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-6				GAAATTCAATTTATTTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26428996313220732					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477195	8477245	8324599	8324649	15915	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-7				GTAAACAGTTCTAGGTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44415986426387771					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477038	8477088	8324442	8324492	15916	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-8				TTTAAGAGTTAGCCATCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95689525164957245					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477104	8477154	8324508	8324558	15917	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12-9				TCAGTTTAGAAAGGGGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.546354743319176					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477356	8477406	8324760	8324810	15918	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12/SOX2e-24				ACAAGTTAAGTCCTTGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.635000963381785					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35620	chr12	8477367	8477417	8324771	8324821	15919	hg38	N/A	enh2171	N/A	Enhatls38662	enhancer	NANOGe-12/SOX2e-24				CACTGGCAGCCCCTTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.1752916214742752					FAM90A1	chr12	8221259	8227618	88112				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	930
enhrx-35627	chr12	8628339	8628389	8475743	8475793	15920	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-1				AAAACACCCTAACTCTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29521591633770777					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628468	8628518	8475872	8475922	15921	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-10				TTAAAGACAATTCTGTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47999064833219679					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628114	8628164	8475518	8475568	15922	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-11				CTGAAATCCAGGGGAACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4099836808788766					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628193	8628243	8475597	8475647	15923	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-12				GGCAGGAAGAAATAAAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43617260849029549					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628236	8628286	8475640	8475690	15924	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-13				CAGGACCTGAATAGAACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093343408558301977					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628103	8628153	8475507	8475557	15925	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-14				AGTTCAAAGGCCTGAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23027600723389641					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628223	8628273	8475627	8475677	15926	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-15				GAACAAAAGGCAGAGGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.942344666731046					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628279	8628329	8475683	8475733	15927	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-16				TAGATTGCCCTCCCCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9701901974463143					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628314	8628364	8475718	8475768	15928	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-17				GATGAGATTAGCATTTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6398903265980069					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628350	8628400	8475754	8475804	15929	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-2				ACTCTCATCTGGTCACCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6958390250765415					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628149	8628199	8475553	8475603	15930	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-3				CATCAATCTTTTACTAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56621015234166128					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628255	8628305	8475659	8475709	15931	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-4				ATGCATTAGCCAATCTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43555328714509461					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628267	8628317	8475671	8475721	15932	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-5				GGCTAATGCATACCCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.359764221468992					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628168	8628218	8475572	8475622	15933	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-6				GATGTCTTAGGTCAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02420886006027188					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628132	8628182	8475536	8475586	15934	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-7				AATGGTGTAAATCTAGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.208590540575911					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628400	8628450	8475804	8475854	15935	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-8				TATATGTTGAGATGGTGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12732381004733481					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35627	chr12	8628373	8628423	8475777	8475827	15936	hg38	N/A	N/A	N/A	Enhatls38668	enhancer	NANOGe-13-9				TTCTATGCATCAATCTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32647818127203981					CLEC6A	chr12	8455961	8478330	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	937
enhrx-35645	chr12	8789009	8789059	8636413	8636463	15937	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-1				GCCACATTCCCCTCTCCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52571159573951565					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788997	8789047	8636401	8636451	15938	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-10				GGGAATGTGGCAGGACAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56790534119021563					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8789053	8789103	8636457	8636507	15939	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-11				TGCTGAGGGAACTCAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2087712478067141					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788934	8788984	8636338	8636388	15940	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-12				ATGTCTCTGCATCATAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19560087606660859					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788818	8788868	8636222	8636272	15941	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-13				AGATAGGAGAAAACCGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26884314452640617					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788834	8788884	8636238	8636288	15942	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-14				ATGTCTCATCTCCAGCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16254634635421181					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8789038	8789088	8636442	8636492	15943	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-15				ATAATGATCAATAAATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.026790984086907291					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788431	8788481	8635835	8635885	15944	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-16				TAATGGATTTAGGGCTATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1621625399693773					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788691	8788741	8636095	8636145	15945	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-17				CTGAGGAGGATTAGAAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13027497330194379					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788795	8788845	8636199	8636249	15946	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-18				CAGTAGATGGAATATACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.259436855746656					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788414	8788464	8635818	8635868	15947	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-19				TGTGTCGACTCAAGGTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41252204708957507					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788565	8788615	8635969	8636019	15948	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-2				CAATACCTGGCTTTCCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.045779627242936					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788513	8788563	8635917	8635967	15949	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-20				GTCCCTGTGTACTTGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.146124372769904					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788551	8788601	8635955	8636005	15950	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-21				GGCCGCAGGGACCTCCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19569178498118481					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788460	8788510	8635864	8635914	15951	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-23				TTTGTTAAACAAATGCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20301131889605639					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788538	8788588	8635942	8635992	15952	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-24				AAACACTGCGGAAGGCCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1160762534762016					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788625	8788675	8636029	8636079	15953	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-25				CAGGTCTTTCCCTTCCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35964648284521372					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788644	8788694	8636048	8636098	15954	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-26				TGTCGGGCTGGGGGACGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.47186141390525					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788674	8788724	8636078	8636128	15955	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-27				CCCGTAAAGGGTCTGTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.843978869049681					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788610	8788660	8636014	8636064	15956	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-28				TAGTCTGAAATATGGCCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30681083392178288					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788589	8788639	8635993	8636043	15957	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-29				TATCACATGGGGAGAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78730543941965681					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788661	8788711	8636065	8636115	15958	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-3				CCGACACCCGACACCCGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1362318021094808					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788765	8788815	8636169	8636219	15959	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-30				ACCGAGACATTCCATTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15183057752948251					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788321	8788371	8635725	8635775	15960	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-31				TTTCTTAGTACAGAACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.20358108807756					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788578	8788628	8635982	8636032	15961	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-32				GAGAAACCTTGGACAATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49347454639127858					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788526	8788576	8635930	8635980	15962	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-33				ACACAGGGACACAAACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.869725707215963					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788351	8788401	8635755	8635805	15963	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-4				AGATTAACAGCATCTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25471887131408077					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788381	8788431	8635785	8635835	15964	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-5				TACCCCCAACCCTGTGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38829682652435082					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8789024	8789074	8636428	8636478	15965	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-6				GATCATTATCTCTGCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.563611545620304					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788922	8788972	8636326	8636376	15966	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-7				CATAAACAAGGTAAAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62195701846199625					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788981	8789031	8636385	8636435	15967	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-8				AATAGGGTAATAGTGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050939336803905319					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35645	chr12	8788754	8788804	8636158	8636208	15968	hg38	N/A	N/A	N/A	Enhatls38686	enhancer	NANOGe-14-9				TTCTGCTCATCCCTGGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14289706432877469					MFAP5	chr12	8637345	8662884	257				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	955
enhrx-35658	chr12	8845387	8845437	8692791	8692841	15969	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-1				GTTGTCAGGCTGGTTCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1233592464413789					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845373	8845423	8692777	8692827	15970	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-10				CTACTGCAAAGACTGTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54010127450405					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845470	8845520	8692874	8692924	15971	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-11				AGAACCTTGACTAGCAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87506051009113361					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845470	8845520	8692874	8692924	15972	hg38	N/A	enh14513	N/A	N/A	enhancer	NANOGe-15-11				AGAACCTTGACTAGCAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87506051009113361					RIMKLB	chr12	8697176	8783085	2058				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845249	8845299	8692653	8692703	15973	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-12				AATGCAGATGCCAGACACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13238087677371549					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845414	8845464	8692818	8692868	15974	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-13				CTCCAGGAGAGGAAACAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1287160023179775					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845181	8845231	8692585	8692635	15975	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-14				GTGGAAAGAAAACACAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13837243916558961					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845200	8845250	8692604	8692654	15976	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-15				CACAGAAGAGAAAGAATGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1204625152640669					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845305	8845355	8692709	8692759	15977	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-16				GCTGAGATGGAGCAGGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21278009971542181					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845229	8845279	8692633	8692683	15978	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-17				AGGGAGGAAAGACCATACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37710324932366462					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845322	8845372	8692726	8692776	15979	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-18				AAAAGGAGGAGGGATGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.548854717961712					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845459	8845509	8692863	8692913	15980	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-2				TAGCAAATAAGGAACGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01548316651161382					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845459	8845509	8692863	8692913	15981	hg38	N/A	enh14513	N/A	N/A	enhancer	NANOGe-15-2				TAGCAAATAAGGAACGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01548316651161382					RIMKLB	chr12	8697176	8783085	2058				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845519	8845569	8692923	8692973	15982	hg38	N/A	enh14513	N/A	N/A	enhancer	NANOGe-15-3				AACTGCAAAATTCACGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050662088679692872					RIMKLB	chr12	8697176	8783085	2058				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845217	8845267	8692621	8692671	15983	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-4				TCTGTGATTCAGCCAATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27128575953740269					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845508	8845558	8692912	8692962	15984	hg38	N/A	enh14513	N/A	N/A	enhancer	NANOGe-15-5				TCACGTGGCTGGAGAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64954465176930465					RIMKLB	chr12	8697176	8783085	2058				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845292	8845342	8692696	8692746	15985	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-6				CTCAGTTTAATGTGCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.275832632380709					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845136	8845186	8692540	8692590	15986	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-7				GATACAATTAAAGAAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.003344353961134					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845163	8845213	8692567	8692617	15987	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-8				CTTGGCAAGAAACATGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24195760766684249					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35658	chr12	8845403	8845453	8692807	8692857	15988	hg38	N/A	enh14513	N/A	Enhatls38697	enhancer	NANOGe-15-9				TAGCCGGCTGGCTCCAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6534934209513947					RIMKLB	chr12	8697176	8783085	4273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	968
enhrx-35666	chr12	8940912	8940962	8788316	8788366	15989	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16-32				TCTTGCTACTGCTCACTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035030693447301593					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940871	8940921	8788275	8788325	15990	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGAACAAAGCTTCCACAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50530375731168753					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940711	8940761	8788115	8788165	15991	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGAACCTTTGTATCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77566231124151319					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8941036	8941086	8788440	8788490	15992	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGCTCTTAAGGCGGCACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4205674525371727					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940953	8941003	8788357	8788407	15993	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGCTGTAACACTCACCACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55211905669487116					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940607	8940657	8788011	8788061	15994	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGGGTTTGTGAGTGCACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57436772310207718					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8941013	8941063	8788417	8788467	15995	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				AGTTGTTCGTTCCTCCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34808871540386072					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940659	8940709	8788063	8788113	15996	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				ATCCACACAAAGGTTCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.20156652526551					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940827	8940877	8788231	8788281	15997	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CACTGCTGGCTGGGGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4638417849635596					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940809	8940859	8788213	8788263	15998	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CCAGATAAGAGAATGAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63837200277537742					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940841	8940891	8788245	8788295	15999	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CCAGCAGTGGCAACCCGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1408683678694102					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940499	8940549	8787903	8787953	16000	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CTAGACATAAAGGTTCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28948077339731471					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940366	8940416	8787770	8787820	16001	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CTAGACATAAATACACCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17936901605754749					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940990	8941040	8788394	8788444	16002	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CTCGTGGTCTCGCTGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2289102066893437					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940780	8940830	8788184	8788234	16003	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				CTCTACCAATCAGCAGGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92419594916140246					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8941002	8941052	8788406	8788456	16004	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GAGACCACGAGCCCGCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.078209357580934155					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940623	8940673	8788027	8788077	16005	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GATAGATACAGAGTGTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1595388784580615					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940756	8940806	8788160	8788210	16006	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GCCCTGTCAAAACAGACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15659264530327591					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940422	8940472	8787826	8787876	16007	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GCTAGACACAGGGTGCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3968748654676759					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940463	8940513	8787867	8787917	16008	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GCTAGATACAGAGTGTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46570481483125808					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940976	8941026	8788380	8788430	16009	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GGCTTCAGGAGTGAAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.808972242329412					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8941048	8941098	8788452	8788502	16010	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GGTGAGTGTTACAGCTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1317482120992691					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940349	8940399	8787753	8787803	16011	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				GTCTAGCTCAGGGATTGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23679887291530191					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940937	8940987	8788341	8788391	16012	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TACAGCTCATAAAAGCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85199873110720126					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940681	8940731	8788085	8788135	16013	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TACTCTGTATCTAATCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019574945294415291					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940474	8940524	8787878	8787928	16014	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TCTGTATCTAGCTGCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59714464523523592					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940634	8940684	8788038	8788088	16015	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TCTGTATCTATCTGCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95973784841263576					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940724	8940774	8788128	8788178	16016	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TGCGTTTACAATCCCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21250662142835411					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940859	8940909	8788263	8788313	16017	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17				TTGGGTCCCCTTCCACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.029400468677898431					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940433	8940483	8787837	8787887	16018	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17/-23				ACAAACCCTGAGCTAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54182209675322512					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940381	8940431	8787785	8787835	16019	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17/-23				GCTAGATACAGAGTGCCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32303112351724511					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8940582	8940632	8787986	8788036	16020	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-16/-17/-23/EOMESe+16				GCTAGACACAGGGTGCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18331903314140929					RIMKLB	chr12	8697176	8783085	20				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947744	8947794	8795148	8795198	16021	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-11				ACCCGGTGAATCCCGCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13896785029158359					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947634	8947684	8795038	8795088	16022	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-15				GGGGGTGGCGCTCGTCGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31063058713322411					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947702	8947752	8795106	8795156	16023	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-2				TGCGGGCGCACGCAGGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.393494876002104					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947661	8947711	8795065	8795115	16024	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-24				GTCGATGGGACTGGGTGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20664429979536589					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947687	8947737	8795091	8795141	16025	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-28				CGCCCGCACTCCTCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34075300791745661					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947675	8947725	8795079	8795129	16026	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-34				TCAGCCCTTGGGTGGTCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.065386682763015916					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8948557	8948607	8795961	8796011	16027	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-17-36				TGGTGGGTTCGTGGTCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58588368700307636					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947732	8947782	8795136	8795186	16028	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-41				CTCCACCTGCAGCCCCGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68119084650995054					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8948372	8948422	8795776	8795826	16029	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-17-42				CTTGCTACTGCTCACTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1680697967947839					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947649	8947699	8795053	8795103	16030	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-44				GGGTGCCGTGGAGCAGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1851905338427855					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8948528	8948578	8795932	8795982	16031	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-17-46				AGTGAAGCTGCAGACCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1467932295930551					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947761	8947811	8795165	8795215	16032	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-7				GGAGCCCAGCTGGCTTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55915239232986647					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8947782	8947832	8795186	8795236	16033	hg38	N/A	enh111872	N/A	Enhatls38705	enhancer	NANOGe-17-9				TCCAAAGCCCCACCAGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5018197283284439					RIMKLB	chr12	8697176	8783085	8205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957512	8957562	8804916	8804966	16034	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-1				CACCTGGATGTGTAGGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48273251863744482					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957694	8957744	8805098	8805148	16035	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-10				GTCAAAGGGGAGTTGTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54594869063819285					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957615	8957665	8805019	8805069	16036	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-11				TCTTATGAAATTCCTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3995798763450511					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957491	8957541	8804895	8804945	16037	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-12				GGGGATATGATAGCTTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3946735503150061					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957808	8957858	8805212	8805262	16038	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-13				AATAAAGCTTTTAATCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61115122442739178					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957770	8957820	8805174	8805224	16039	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-14				TCCGAAAAGAGAGTCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.110060082177555					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957757	8957807	8805161	8805211	16040	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-15				TCAGTGAAGGGAGATAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.0738792406687141					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957563	8957613	8804967	8805017	16041	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-18				CATTTTCACTTCTTTTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1226571298421516					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957642	8957692	8805046	8805096	16042	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-2				GTAGGGGAGCTTTTGAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36063140573881591					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957791	8957841	8805195	8805245	16043	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-20				GACTCAGCCCACCTGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.8360453808376862					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957459	8957509	8804863	8804913	16044	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-3				GTATATATATACAAACTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010597849765466129					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957671	8957721	8805075	8805125	16045	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-4				CGGGCATAATGGGGGTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33763146945244737					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957682	8957732	8805086	8805136	16046	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-5				TTGTTCTCTGGCGGGCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31106510487114181					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957528	8957578	8804932	8804982	16047	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-6				TAAGGCAGGAACAAGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.088169288048878					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957597	8957647	8805001	8805051	16048	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-7				TAAGACAATGTTATCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54894746552760809					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957627	8957677	8805031	8805081	16049	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-8				AGCCAGGGTGAGCCAGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78751010614727768					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957709	8957759	8805113	8805163	16050	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18-9				TAAAGGAAAATTACTGTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.013057861528749069					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957843	8957893	8805247	8805297	16051	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18/GATA6e-13				ATGTGAAGAGACCACCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.688189866599711					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957743	8957793	8805147	8805197	16052	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18/GATA6e-13				TAGGGGTGGGGCCGTTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.279189517762747					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957726	8957776	8805130	8805180	16053	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18/GATA6e-13				TATAGGATTTGGGTAGGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.747361062454873					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957829	8957879	8805233	8805283	16054	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18/GATA6e-13				TTGCTCACACAAAGCCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.671384599151776					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8957658	8957708	8805062	8805112	16055	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-18/GATA6e-13/SMAD4e-11				GGTCACAAGGTGCTCAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68515668021212406					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959377	8959427	8806781	8806831	16056	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-1				GAGCTAAAGGCATATAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.940438133589639					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959236	8959286	8806640	8806690	16057	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-10				AGCAGAGGCTGAGCAAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027664817667110739					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959211	8959261	8806615	8806665	16058	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-11				GCTCCTCGCCAGGCCGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3192798102329091					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959186	8959236	8806590	8806640	16059	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-12				TGACCTCTCCCTTCCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65247567234282711					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959199	8959249	8806603	8806653	16060	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-13				TGGCGAGGAGCAGCCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57985837306275057					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959289	8959339	8806693	8806743	16061	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-15				AAGCCGGACCAGGTGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2341547435479829					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959251	8959301	8806655	8806705	16062	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-16				ATTATAGGGTGGAGGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2727110871851339					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959262	8959312	8806666	8806716	16063	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-17				GTGATAAAAGGATTATAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.007733875822173					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959364	8959414	8806768	8806818	16064	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-18				AAAAAGGTGGCTGGAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77032053224611452					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959093	8959143	8806497	8806547	16065	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-19				GGAGGGAAAGAAGGAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.9828217697123789					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959063	8959113	8806467	8806517	16066	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-2				TGCACTGGGCACAGAGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67530652063056551					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959167	8959217	8806571	8806621	16067	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-20				GTCAGATGGGTCTGTAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.286893592498668					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959224	8959274	8806628	8806678	16068	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-21				GCAAGAATTGGGACCTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81271472190917649					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959323	8959373	8806727	8806777	16069	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-22				AGGTGGGGGAGGGCTAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32184399944677022					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959125	8959175	8806529	8806579	16070	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-3				GACACTTGGGATTGGTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06610160655346331					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959111	8959161	8806515	8806565	16071	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-4				GTACTGAGGGGACAGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.7774230936720992					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959305	8959355	8806709	8806759	16072	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-5				CATGGAACGAAACTGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38406855570501308					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959077	8959127	8806481	8806531	16073	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-6				GATTTGGGACAAGTTGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51904488701650808					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959138	8959188	8806542	8806592	16074	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-7				AGAAAGACTCAGCGACACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0041217798152819					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959337	8959387	8806741	8806791	16075	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-8				GTAAATTTCTGGGCAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.854524961581574					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959351	8959401	8806755	8806805	16076	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19-9				GAAATTTACTCTTAAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.107169500497958					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35666	chr12	8959274	8959324	8806678	8806728	16077	hg38	N/A	N/A	N/A	Enhatls38705	enhancer	NANOGe-19/SMAD4e-12				TGAGGAGGGGAGGTGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6768145071194329					A2ML1	chr12	8822620	8876787	12252				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	976
enhrx-35565	chr12	8004335	8004385	7851739	7851789	16078	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2-15				TGGAGATTAAAAGATGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43037135400114729					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004355	8004405	7851759	7851809	16079	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2-5				CTGAGAGGAGCAATGTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99878839464231028					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004546	8004596	7851950	7852000	16080	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2-6				GAAGTCACTGTCCCGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24251063518008689					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004571	8004621	7851975	7852025	16081	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2-8				CTTATTAGTGAGAGAGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.162322623889327					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004450	8004500	7851854	7851904	16082	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				AAAAGAAATGCCACAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0216343676982058					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004655	8004705	7852059	7852109	16083	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				AAGCTCTGTTCTTATCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.113149299583594					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004382	8004432	7851786	7851836	16084	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				AAGTAAATAGCTTCATTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63048091812772333					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004631	8004681	7852035	7852085	16085	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				ATAGCTACATGTCTCACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60000557008537581					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004478	8004528	7851882	7851932	16086	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				ATTCCAATGTCCCCACGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.61850632862506					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004535	8004585	7851939	7851989	16087	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				ATTCTTATCTACCTGGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51738223448200371					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004619	8004669	7852023	7852073	16088	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				CATGTAGCTATTTTGGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03047030006340009					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004467	8004517	7851871	7851921	16089	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				GGACATTGGAATCTTTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.329570482276608					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004490	8004540	7851894	7851944	16090	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				GTCTCTGCACGTCCTCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57379569566072353					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004370	8004420	7851774	7851824	16091	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				TCATTCTCAGGCTACCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2119587892009189					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8004429	8004479	7851833	7851883	16092	hg38	N/A	enh68024	N/A	Enhatls38606	enhancer	NANOGe-2/-7				TTGTATTGACTGCAGCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072300266278749414					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-lit165	chr12	8972253	8972303	8819657	8819707	16093	hg38					enhancer	NANOGe-20-1				GTCGTGGAGCTGAACGAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27214079687221082													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972054	8972104	8819458	8819508	16094	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-10				AACTCCCTGTGGTTCTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1443816098743832					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit166	chr12	8972360	8972410	8819764	8819814	16095	hg38					enhancer	NANOGe-20-11				GTACACAAGAGAGAAGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42948559324377961													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit167	chr12	8972346	8972396	8819750	8819800	16096	hg38					enhancer	NANOGe-20-12				CTTGTGTACTTGTCTCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41511555380186632													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8971842	8971892	8819246	8819296	16097	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-13				CAATGCTAATTGAAAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1228385249721015					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8972005	8972055	8819409	8819459	16098	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-14				CACTACAGTAGGAAAAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28441312045503853					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit168	chr12	8972192	8972242	8819596	8819646	16099	hg38					enhancer	NANOGe-20-15				GAGGAACACAGTCCTTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.562956752509365													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972152	8972202	8819556	8819606	16100	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-16				GACTACAGTGACTGATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26360293984386252					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit169	chr12	8972179	8972229	8819583	8819633	16101	hg38					enhancer	NANOGe-20-17				TGTGTTCCTCCCTCTCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14661095403703681													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972083	8972133	8819487	8819537	16102	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-18				ATCACAGTACCCCATCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6109253541049644					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit170	chr12	8972313	8972363	8819717	8819767	16103	hg38					enhancer	NANOGe-20-19				AAGAAAAGCTTGTGTGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063003408693481339													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8971774	8971824	8819178	8819228	16104	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-2				GGTCTCGAGCTCCTACGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1040961766314631					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8971874	8971924	8819278	8819328	16105	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-20				AATAATGTTTTCATGATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.07516037967118					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8972016	8972066	8819420	8819470	16106	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-21				TTCAAAGAAATCACTACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24543800451920841					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit171	chr12	8972375	8972425	8819779	8819829	16107	hg38					enhancer	NANOGe-20-22				GGACTGGGAGGAGTCGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0055606871389594636													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972043	8972093	8819447	8819497	16108	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-23				TTCCCCTCCCCAACTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30327787271969858					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8971828	8971878	8819232	8819282	16109	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-24				AGGGGTTGGGGCTGGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1076069871176292					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8971785	8971835	8819189	8819239	16110	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-25				ACTTTGGGAGGCCGATCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48216287001751978					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8971753	8971803	8819157	8819207	16111	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-26				TTTCGCCATGTTGACTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045535438483760453					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit172	chr12	8971719	8971769	8819123	8819173	16112	hg38					enhancer	NANOGe-20-27				CTGGCTAATTTTTGTATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31492333737404649													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit173	chr12	8971730	8971780	8819134	8819184	16113	hg38					enhancer	NANOGe-20-28				TTGTATTTTTGGGAGAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1413786373388484													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit174	chr12	8971681	8971731	8819085	8819135	16114	hg38					enhancer	NANOGe-20-29				TCCCGAGTAGCTGAGATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87901400710101452													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit175	chr12	8972294	8972344	8819698	8819748	16115	hg38					enhancer	NANOGe-20-3				TCTTCAAGTCGTAGGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56247710699788167													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit176	chr12	8971652	8971702	8819056	8819106	16116	hg38					enhancer	NANOGe-20-30				GGCAGGAAAATCACTTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5051045713206159													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit177	chr12	8971700	8971750	8819104	8819154	16117	hg38					enhancer	NANOGe-20-31				TAGGCGCCCACCACCATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5037700058440331													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8971797	8971847	8819201	8819251	16118	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-33				TGTAATCCCAGCACTTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7094328642190759					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8971940	8971990	8819344	8819394	16119	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-4				ATTCAACCGAACTCTTTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12051860247852771					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit178	chr12	8972209	8972259	8819613	8819663	16120	hg38					enhancer	NANOGe-20-5				TTCGGGAATTTCTATAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68903115326579523													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972131	8972181	8819535	8819585	16121	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-6				TCAGGAGGGTATGATAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7719598356770152					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-35667	chr12	8972095	8972145	8819499	8819549	16122	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-7				CATCACCCTGGCCTTTAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1561375598871278					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit179	chr12	8972237	8972287	8819641	8819691	16123	hg38					enhancer	NANOGe-20-8				AATTTTGTCAGTTGGGGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.221475598806847													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35667	chr12	8972106	8972156	8819510	8819560	16124	hg38	N/A	N/A	fant40869	N/A	enhancer	NANOGe-20-9				TGGGTCATTCTCCCACCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24881375421438839					A2ML1	chr12	8822620	8876787	3047				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	977
enhrx-lit180	chr12	8971669	8971719	8819073	8819123	16125	hg38					enhancer	NANOGe-20/GATA6e+11				GCTACTCGGGAGGCTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5812422216781852													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35698	chr12	9064549	9064599	8911953	8912003	16126	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-1				CATCGACAGCCTTTCAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92415720062073725					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064663	9064713	8912067	8912117	16127	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-10				TTTACTCTGCATAACACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02845671559532879					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064447	9064497	8911851	8911901	16128	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-11				AGGTTTACAGGAGAAGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79346179428503594					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064698	9064748	8912102	8912152	16129	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-12				AAAATGGTTCTTCTGAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67073098532177278					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-lit181	chr12	9064228	9064278	8911632	8911682	16130	hg38					enhancer	NANOGe-21-13				AGACACAGGTGGGCTGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61223139036222807													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35698	chr12	9064793	9064843	8912197	8912247	16131	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-14				AAAAAGTTGAGTATTCTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57376182288629385					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064317	9064367	8911721	8911771	16132	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-15				GTTTTTATGCAAATATGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26401870839792069					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064266	9064316	8911670	8911720	16133	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-16				GTTGGTGGTGGGGAGAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17725962241781609					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064298	9064348	8911702	8911752	16134	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-17				TAGGAAGAAGTAGAGAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.458415206327121					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064714	9064764	8912118	8912168	16135	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-18				CTTTTCTTTTTCAAACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3867841927076912					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064390	9064440	8911794	8911844	16136	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-2				TACTAACACCTTTAGGGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69346561906438531					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064614	9064664	8912018	8912068	16137	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-3				AAAGCATTTAATCCGGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25352186953116362					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064640	9064690	8912044	8912094	16138	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-4				TTCTCACCTGTTTAGGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58458888626375571					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064567	9064617	8911971	8912021	16139	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-5				CTCTAAATAAGGAAGGATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42150354657521311					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064602	9064652	8912006	8912056	16140	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-6				GGGCTTCCATTTCCATACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84932916125466873					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064427	9064477	8911831	8911881	16141	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-7				ACAATTTATTGCAGAATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43365305896098832					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064578	9064628	8911982	8912032	16142	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-8				CCTTATTTAGAGAAGTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13658435287447979					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35698	chr12	9064254	9064304	8911658	8911708	16143	hg38	N/A	N/A	fant40875	N/A	enhancer	NANOGe-21-9				TTCACAGCCACAGTTGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1991071146709571					PHC1	chr12	8913895	8941467	1671				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1008
enhrx-35790	chr12	9517345	9517395	9364749	9364799	16144	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-1				GCTCATCTGCTCGGTTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22000539687834819					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517462	9517512	9364866	9364916	16145	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-10				AGCAACAGCAGGCGCTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0072755029064457332					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9516981	9517031	9364385	9364435	16146	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-11				ACGAAATCCCACTGGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52137453195445826					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517149	9517199	9364553	9364603	16147	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-12				AGCAGGGAGAGCTTATGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26273952503163173					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517377	9517427	9364781	9364831	16148	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-13				TTGGTTTCCAAGCCCTAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035194619174952292					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517327	9517377	9364731	9364781	16149	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-14				TCAGGGCTCAGCTGCATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.003406633341212642					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517506	9517556	9364910	9364960	16150	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-15				GAAAGATATAAGAGCATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63598778381751075					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517439	9517489	9364843	9364893	16151	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-16				GCCCAGCAGCAGTTTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.331471810642					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517481	9517531	9364885	9364935	16152	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-17				TTGGCTTGATTGTGAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14705675600149759					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517451	9517501	9364855	9364905	16153	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-18				TTTGTCCTGGGAGCAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10489386754559329					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517279	9517329	9364683	9364733	16154	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-19				TCATATGCAAATGAACCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076121785351527346					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517542	9517592	9364946	9364996	16155	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-2				TATGTGATCGCTCCCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24727881670836019					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517035	9517085	9364439	9364489	16156	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-20				ATATGATAGAGATGTGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93575110015240359					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517401	9517451	9364805	9364855	16157	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-21				AGTCTCTGTCAGACTGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.181926341849305					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517197	9517247	9364601	9364651	16158	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-22				ATTCATTTTACACTGAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44317161772129537					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517252	9517302	9364656	9364706	16159	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-23				TATAGCAAAATTTGCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39427897578757309					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517264	9517314	9364668	9364718	16160	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-24				TGCTGCCCAGGTTCCCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21751829233731529					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517571	9517621	9364975	9365025	16161	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-25				TATTTAAAACAGAAACCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016018738274890611					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517219	9517269	9364623	9364673	16162	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-26				TGTGCGTTCAGAGAACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70711146607176623					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517303	9517353	9364707	9364757	16163	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-27				AAGCAAATGCAAATGAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35886150586028148					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517412	9517462	9364816	9364866	16164	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-28				GACTGTGGCTGGCTGGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49035988457396068					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517058	9517108	9364462	9364512	16165	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-29				TTAGGCCTTTGTCTGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44168627235728608					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517595	9517645	9364999	9365049	16166	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-3				GAGTACCTCAGTGAGTCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065335416703530352					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517358	9517408	9364762	9364812	16167	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-30				GCAGATGAGCTCTGATTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77038837814618255					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517133	9517183	9364537	9364587	16168	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-31				CTAAGGTCTGCAAAATAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.103141258830124					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517071	9517121	9364475	9364525	16169	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-32				TGCCTTGTGGTCAGGTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29085455234773361					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517606	9517656	9365010	9365060	16170	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-4				TGAGTCATAGGGAGTCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68057638870700776					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517116	9517166	9364520	9364570	16171	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-5				CCCCTGTTTCACTTTGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34868894151065088					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517554	9517604	9364958	9365008	16172	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-6				CAGTGGCTACAGCCGGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63947643249417729					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9516996	9517046	9364400	9364450	16173	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-7				GATTTCGTTGTGGTGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1716463434889049					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517389	9517439	9364793	9364843	16174	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-8				TGACAGAGACTCCCAGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35406018652900911					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-35790	chr12	9517013	9517063	9364417	9364467	16175	hg38	N/A	enh2179	N/A	N/A	enhancer	NANOGe-22-9				TCATGCTGGACAAAGATCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01365856585973097					PZP	chr12	9148839	9208395	155068				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1100
enhrx-lit182	chr12	9603106	9603156	9450510	9450560	16176	hg38					enhancer	NANOGe-23-1				GCCGGCGGGCGGCTCAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76896305754987615													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602887	9602937	9450291	9450341	16177	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-10				GCTAGACATAAAGGTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23130540593014559					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit183	chr12	9603077	9603127	9450481	9450531	16178	hg38					enhancer	NANOGe-23-11				GCCATGGGCTCCTACGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0776022916737156													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit184	chr12	9603034	9603084	9450438	9450488	16179	hg38					enhancer	NANOGe-23-12				ACTGGGCACCGCGGATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36685361128568922													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602911	9602961	9450315	9450365	16180	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-13				CTGAGTTCCTAAGTCTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22292566785326109					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-35814	chr12	9602779	9602829	9450183	9450233	16181	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-14				GGGTTTGTGAATGAACCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24844191854134451					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit185	chr12	9603231	9603281	9450635	9450685	16182	hg38					enhancer	NANOGe-23-15				ACTAAACCCCTCACTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.263577442598234													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit186	chr12	9603157	9603207	9450561	9450611	16183	hg38					enhancer	NANOGe-23-16				GTCCCGAGCCCTGCCCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22322872339311781													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit187	chr12	9603015	9603065	9450419	9450469	16184	hg38					enhancer	NANOGe-23-17				CAGTCCCATCAACCCCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085807081335675717													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit188	chr12	9603047	9603097	9450451	9450501	16185	hg38					enhancer	NANOGe-23-18				GATTAGGGGGCGGCGCTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45848336397262113													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602764	9602814	9450168	9450218	16186	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-19				ACTAGATACTGAGTGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50575008533384846					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit189	chr12	9603124	9603174	9450528	9450578	16187	hg38					enhancer	NANOGe-23-2				CATGGCGGGCTGCTCAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2397407106192942													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602753	9602803	9450157	9450207	16188	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-20				TCAGTATCTAGTTAATCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.186694099227475					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit190	chr12	9603135	9603185	9450539	9450589	16189	hg38					enhancer	NANOGe-23-21				GCTCAGTCATGGTGGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20656722993553919													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit191	chr12	9603207	9603257	9450611	9450661	16190	hg38					enhancer	NANOGe-23-22				AGCACGGCAGCTGCTGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30513507594565													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit192	chr12	9603169	9603219	9450573	9450623	16191	hg38					enhancer	NANOGe-23-23				GCCCCGCGGGGAGGCAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.175542762995613													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602840	9602890	9450244	9450294	16192	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-24				GGCACTCTGTATCTAGTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25013475907760668					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit193	chr12	9603058	9603108	9450462	9450512	16193	hg38					enhancer	NANOGe-23-25				GGCGCTCGTCGGGCAGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72095671468559774													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602703	9602753	9450107	9450157	16194	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-29				GGGATTGTGAATGCACCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40710402829491671					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit194	chr12	9602938	9602988	9450342	9450392	16195	hg38					enhancer	NANOGe-23-3				CTTCACCAAGTGGATGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05183652429446596													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit195	chr12	9603002	9603052	9450406	9450456	16196	hg38					enhancer	NANOGe-23-4				CGGCACTCCTCAGCCCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32034184666178711													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit196	chr12	9602982	9603032	9450386	9450436	16197	hg38					enhancer	NANOGe-23-5				GCCAATCCCGCGCTGTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65416198177308471													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit197	chr12	9603091	9603141	9450495	9450545	16198	hg38					enhancer	NANOGe-23-6				GCCCATGGCTGGGGCGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37860757650150068													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35814	chr12	9602724	9602774	9450128	9450178	16199	hg38	N/A	enh98904	N/A	N/A	enhancer	NANOGe-23-7				GGAGAACCTTTGTCTAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097188909864036013					KLRB1	chr12	9594550	9607916	144232				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1124
enhrx-lit198	chr12	9602951	9603001	9450355	9450405	16200	hg38					enhancer	NANOGe-23-8				ATGCGGCAGGGGGCAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3014399518674451													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit199	chr12	9603191	9603241	9450595	9450645	16201	hg38					enhancer	NANOGe-23-9				GCCCGGCGAGAAATGGAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03078613193310158													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35565	chr12	8013229	8013279	7860633	7860683	16202	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-1				ACGCCTTATGGTGAGGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.803381862036153					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013229	8013279	7860633	7860683	16203	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-1				ACGCCTTATGGTGAGGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.803381862036153					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012665	8012715	7860069	7860119	16204	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-10				ATCCTTGGTATTACCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23093256240396329					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012938	8012988	7860342	7860392	16205	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-11				GAGGTCTAAAAAGTAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3398571946946331					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013175	8013225	7860579	7860629	16206	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-12				TTCCAACTGGTCCTTCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22899888203094679					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012949	8012999	7860353	7860403	16207	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-13				AGTAGTAGGGGGCTCTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3268372368696051					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012736	8012786	7860140	7860190	16208	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-14				TTTTTCTCCAGGGCCAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47759838433953161					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013368	8013418	7860772	7860822	16209	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-15				AGTTGACAAGTAAGTGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32113760153150189					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013188	8013238	7860592	7860642	16210	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-16				TGGAGTCTTGGCATTCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15689355257806961					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013217	8013267	7860621	7860671	16211	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-17				ACTGCAAGAAAAACGCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1474136873185832					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012699	8012749	7860103	7860153	16212	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-18				AGATATACACTGCCACCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25815296530956189					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012723	8012773	7860127	7860177	16213	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-19				TGCGCCATCCCTCCCAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1012052384771587					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013044	8013094	7860448	7860498	16214	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-2				AAACTCCGGAAATACACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27788227671039278					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013073	8013123	7860477	7860527	16215	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-20				AGGTGATAATTCACTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41171889431159192					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012630	8012680	7860034	7860084	16216	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-21				ACAGCAACGGGCTCTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.203660164042481					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013200	8013250	7860604	7860654	16217	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-22				TGCAGTGATTTATGGAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1157187044060841					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013267	8013317	7860671	7860721	16218	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-23				GTCATCTGTGGATTCTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088095479709760852					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013267	8013317	7860671	7860721	16219	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-23				GTCATCTGTGGATTCTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088095479709760852					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012782	8012832	7860186	7860236	16220	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-24				TACAGCTGAGGTGAGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22399282737703241					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012676	8012726	7860080	7860130	16221	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-25				TACCAGAGCTGGTTAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2317789778447564					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013296	8013346	7860700	7860750	16222	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-26				AACCTCAGAAGGACTGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33677442864327878					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012759	8012809	7860163	7860213	16223	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-27				CTGGAAGTGAGAATTAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06416756881903421					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012770	8012820	7860174	7860224	16224	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-28				AATTAGCACAGGTACAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22249520963288					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012594	8012644	7859998	7860048	16225	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-29				GACACTGCTCCACCCACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.185159530436379					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013106	8013156	7860510	7860560	16226	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-3				CAAGGATTTCCCGCTGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20993889380281919					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013331	8013381	7860735	7860785	16227	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-30				GTTTCCATCAGTATTGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10556128233230461					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012967	8013017	7860371	7860421	16228	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-31				GAGGGACAGCCATGTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1352218182154881					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012967	8013017	7860371	7860421	16229	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-31				GAGGGACAGCCATGTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1352218182154881					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012807	8012857	7860211	7860261	16230	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-32				TGTGGATTGTGTATTTAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56287270646549714					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013143	8013193	7860547	7860597	16231	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-33				TGATTGGATCAGAGGCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14565813206845921					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012847	8012897	7860251	7860301	16232	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-34				CTCAGAGAAGAGGATAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44442170107288193					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012830	8012880	7860234	7860284	16233	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-35				TCTGAGGGCTTTGCTTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069479527754172724					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013124	8013174	7860528	7860578	16234	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-36				ATCAGCGCACACCTTCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92361608866563871					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013164	8013214	7860568	7860618	16235	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-37				GGAAAAGAATCCCAGCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.003263933076116382					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012859	8012909	7860263	7860313	16236	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-38				GATAAATTTGGGAACATTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29508611389579109					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012870	8012920	7860274	7860324	16237	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-39				GAACATTTAGGGAAAATATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89238303540864128					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012918	8012968	7860322	7860372	16238	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-4				CTCATTATACTCTCGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.579780708582361					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013307	8013357	7860711	7860761	16239	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-40				ATCTGTTTAACAACCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54968439714801565					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013279	8013329	7860683	7860733	16240	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-41				GTGAGGCAGTGAGTCATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54486154215710969					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012903	8012953	7860307	7860357	16241	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-42				AAGGAAAGGAAATTGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43047914997071152					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012884	8012934	7860288	7860338	16242	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-43				AATATCAGGCAGAAGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2009707988912779					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012747	8012797	7860151	7860201	16243	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-44				CTCACTTCCAGTTTTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15713385644600411					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013406	8013456	7860810	7860860	16244	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-45				GAGACAGAGTTTCACTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27440268554523661					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012985	8013035	7860389	7860439	16245	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-5				TAGTTCCTAAAGGAATGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.115895382566905					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012985	8013035	7860389	7860439	16246	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-5				TAGTTCCTAAAGGAATGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.115895382566905					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8013022	8013072	7860426	7860476	16247	hg38	N/A	enh14507	fant40839	Enhatls38606	enhancer	NANOGe-3-6				TTGTAAAGCCTAGGGCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15841735655298261					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012606	8012656	7860010	7860060	16248	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-7				TTTGCAAAAGCACCAGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27379313552451939					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012687	8012737	7860091	7860141	16249	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-8				GTTAGCAGTTGGCCACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2650835655111427					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35565	chr12	8012642	8012692	7860046	7860096	16250	hg38	N/A	enh14507	N/A	Enhatls38606	enhancer	NANOGe-3-9				GTTACTAGCACCACAGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34343694467746078					SLC2A14	chr12	7812511	7891148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	875
enhrx-35572	chr12	8058508	8058558	7905912	7905962	16251	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-1				GTCGAACTAACTTCCTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.8259880931922687					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058235	8058285	7905639	7905689	16252	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-10				AATTTCAAGCTCAGTTCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.1103542037704068					SLC2A14	chr12	7812511	7891148	11942				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058360	8058410	7905764	7905814	16253	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-11				GGCAAACAGCTGCCAGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.4482999714075548					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058223	8058273	7905627	7905677	16254	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-12				AGCTTGAAATTCACTAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.897685071331517					SLC2A14	chr12	7812511	7891148	11942				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058495	8058545	7905899	7905949	16255	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-13				CAGACAAAAGCTTCCGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.7818431471880984					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058294	8058344	7905698	7905748	16256	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-14				GACACACCAGCTTTTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.59510550186008					SLC2A14	chr12	7812511	7891148	11942				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058294	8058344	7905698	7905748	16257	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-14				GACACACCAGCTTTTCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.59510550186008					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058647	8058697	7906051	7906101	16258	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-15				GGTAGTTGGTATAAACTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038258486441000973					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058671	8058721	7906075	7906125	16259	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-16				TCTCAAGAACATTTTATTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1133383220540394					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058712	8058762	7906116	7906166	16260	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-17				TTGCATTGAAGTAATTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18168932576218411					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058312	8058362	7905716	7905766	16261	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-18				GTGTCCAAGGAAGAAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.787166194829386					SLC2A14	chr12	7812511	7891148	11942				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058312	8058362	7905716	7905766	16262	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-18				GTGTCCAAGGAAGAAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.787166194829386					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058592	8058642	7905996	7906046	16263	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-19				GATTGAAAAGAAGCTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.9175948844858679					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058592	8058642	7905996	7906046	16264	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-19				GATTGAAAAGAAGCTGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.9175948844858679					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058694	8058744	7906098	7906148	16265	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-2				ATTTTAAAGGGTTAAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41650092724654769					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058339	8058389	7905743	7905793	16266	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-20				GACTACAAACCTAAAAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.5156240936344489					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058418	8058468	7905822	7905872	16267	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-21				ATGCCTCCTGGGGCCCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.5734019593929411					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058443	8058493	7905847	7905897	16268	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-22				TTGACTCAAGGGGGAGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9476717456693171					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058555	8058605	7905959	7906009	16269	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-23				TGAATGGGTTCCTGGGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.891430028562322					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058470	8058520	7905874	7905924	16270	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-24				TTGTTAAAGAAAGAAGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16484163806745389					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058372	8058422	7905776	7905826	16271	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-25				CCAGACAGAGGCAGGAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60851367772658349					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058385	8058435	7905789	7905839	16272	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-26				GGAAAGTGGGGGAGAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.6883961648096788					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058682	8058732	7906086	7906136	16273	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-27				ATGTTCTTGAGAATTTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.06549021009031715					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058528	8058578	7905932	7905982	16274	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-3				GACTAAGGATACCGAAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.3808403895368588					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058618	8058668	7906022	7906072	16275	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-4				GTCTCTCCTTAAGCTATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.121517276529163					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058618	8058668	7906022	7906072	16276	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-4				GTCTCTCCTTAAGCTATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.121517276529163					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058431	8058481	7905835	7905885	16277	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-5				CCCCCATGGGCTTTGACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.3085861468705149					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058247	8058297	7905651	7905701	16278	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-6				AGTTCTCGGGGTGAAGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.931945647907173					SLC2A14	chr12	7812511	7891148	11942				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058540	8058590	7905944	7905994	16279	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-7				CGAAATGTAGGAATTTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.5813594393932027					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058636	8058686	7906040	7906090	16280	hg38	N/A	enh51108	N/A	Enhatls38613	enhancer	NANOGe-4-8				ATACCAACTACCCAGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.6659063713628131					SLC2A3	chr12	7919229	8019007	12752				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35572	chr12	8058407	8058457	7905811	7905861	16281	hg38	N/A	enh51108	fant40840	Enhatls38613	enhancer	NANOGe-4-9				GTAAATATTGCATGCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.6416908467094773					SLC2A3	chr12	7919229	8019007	13198				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	882
enhrx-35580	chr12	8086073	8086123	7933477	7933527	16282	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-1				TCACTTACTCCCGGAACGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2056421026906825					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086196	8086246	7933600	7933650	16283	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-10				TGAGGGTCCCTCCCCAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071133890994576079					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085932	8085982	7933336	7933386	16284	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-11				ACATCGGTGCTGCCACCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1554517318210589					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085920	8085970	7933324	7933374	16285	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-12				GTCCTGAAAATCCCAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47784882884574031					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086119	8086169	7933523	7933573	16286	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-13				TATTGGTGGGGAAAATTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92717191838439461					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085948	8085998	7933352	7933402	16287	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-14				CTGGGGTAGACTGTGAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038191565055534969					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086148	8086198	7933552	7933602	16288	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-15				ATCCTGTCCAAGACTGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73854847838635418					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085961	8086011	7933365	7933415	16289	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-16				TCTACCCCAGCCCTCTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39625876035162089					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086131	8086181	7933535	7933585	16290	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-17				AGATGGAGACAATATTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14207637004982809					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085833	8085883	7933237	7933287	16291	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-18				AATCAAGGGAATAAATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56344197554122766					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085844	8085894	7933248	7933298	16292	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-19				TAAATAGACAGGAATGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33897386521203848					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086004	8086054	7933408	7933458	16293	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-2				TAACCCCTAAGGGATAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96098925849825156					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085881	8085931	7933285	7933335	16294	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-3				GAATTTATGTTAACTCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59234809035969493					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085972	8086022	7933376	7933426	16295	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-4				AAGCTGGGTTCCCTTAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12733703310424191					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085859	8085909	7933263	7933313	16296	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-5				GGAAGGGGCAGATAACGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.014000127951688481					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086022	8086072	7933426	7933476	16297	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-6				ACAGGATGTGCATCACTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.055931782107601177					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8085993	8086043	7933397	7933447	16298	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-7				TTCTTTGTAACTAACCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58866844005859575					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086034	8086084	7933438	7933488	16299	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-8				TCACTATGAGGTGAAAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.516673201328224					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35580	chr12	8086184	8086234	7933588	7933638	16300	hg38	N/A	N/A	N/A	Enhatls38621	enhancer	NANOGe-5-9				GTCTTAAAATCCCCTAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19113798677387739					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	890
enhrx-35582	chr12	8123510	8123560	7970914	7970964	16301	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-1				AAAATTGCAAGGCTCTCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23007073427226821					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123423	8123473	7970827	7970877	16302	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-10				ACGTCCCGGCCGCTGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.385786086893967					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123297	8123347	7970701	7970751	16303	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-11				TGTATGCGTGAGTCTTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65159393278580557					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123612	8123662	7971016	7971066	16304	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-12				AAGGGACGTTTGAGGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13865074344162129					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123383	8123433	7970787	7970837	16305	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-13				GGGACAGGATGCGCGCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70285623127990449					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123334	8123384	7970738	7970788	16306	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-14				GAGGAATGTAGCTCGGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31096147759110437					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123229	8123279	7970633	7970683	16307	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-15				TTTGGGTAAATGCGTCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74675220404218867					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123585	8123635	7970989	7971039	16308	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-16				GCACAAAACATCTGCCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35354992417005487					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123347	8123397	7970751	7970801	16309	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-17				CGGGGCTCGGCCCCCGTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2707747806947739					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123498	8123548	7970902	7970952	16310	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-18				CTCTCCGGCGGGCTGGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.180510649178373					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123469	8123519	7970873	7970923	16311	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-19				TCCCGGTGTCCCCCAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2249100505861476					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123240	8123290	7970644	7970694	16312	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-2				CATTTACCCAAATTGGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.691917623525186					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123312	8123362	7970716	7970766	16313	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-20				TTGGGTGGCGAAGAAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	13.16617815792835					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123187	8123237	7970591	7970641	16314	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-21				ACTGACAGTTTAAAAGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48011692764428371					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123434	8123484	7970838	7970888	16315	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-22				GCTGCAGGAAGGCGGGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.268506445119415					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123486	8123536	7970890	7970940	16316	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-23				CTGGGAGTGGGAGGCGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11599519773745171					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123214	8123264	7970618	7970668	16317	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-24				TCATTTTTATTTCTTCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.362793821884					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123256	8123306	7970660	7970710	16318	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-25				CTGCTGTCTCAGCCTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70267821052764035					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123532	8123582	7970936	7970986	16319	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-3				TCAGGAATCGGCGTCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.279961135301293					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123399	8123449	7970803	7970853	16320	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-4				GCGGCGGGTAGCGTGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25246151239183479					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123570	8123620	7970974	7971024	16321	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-5				TTTAAGAGGGTTTCGCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50006441014235647					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123359	8123409	7970763	7970813	16322	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-6				CGCCCTCGGAATCCCAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27487783022717632					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123458	8123508	7970862	7970912	16323	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-7				CCCGCCGACTCCCACATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.459537787144251					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123556	8123606	7970960	7971010	16324	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-8				AAGCCGCCAAAGGTTTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11616831961373029					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8123521	8123571	7970925	7970975	16325	hg38	N/A	enh2167	fant40845	Enhatls38623	enhancer	NANOGe-6-9				GCCGATTCCTGAAAATTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51988504992263906					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8135239	8135289	7982643	7982693	16326	hg38	N/A	enh2167	N/A	Enhatls38623	enhancer	NANOGe-7-10				ACTTATTAGTGAGAGAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6778940136751339					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8135004	8135054	7982408	7982458	16327	hg38	N/A	enh2167	N/A	Enhatls38623	enhancer	NANOGe-7-14				GATGGAGATTAAAAGATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64425942731447106					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8135023	8135073	7982427	7982477	16328	hg38	N/A	enh2167	N/A	Enhatls38623	enhancer	NANOGe-7-6				CATCAGACATTGCTCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48165924090428441					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8135213	8135263	7982617	7982667	16329	hg38	N/A	enh2167	N/A	Enhatls38623	enhancer	NANOGe-7-7				GAAGTCACTGTCCTGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1233449865664558					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171688	8171738	8019092	8019142	16330	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-1				TGTTCACACCCTCCTAACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49191162714479419					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171767	8171817	8019171	8019221	16331	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-10				GGCCAGCCCGCGGCGATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30004628218482932					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171405	8171455	8018809	8018859	16332	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-11				ACCATTCAAAGTCGAATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066949842963694134					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171621	8171671	8019025	8019075	16333	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-12				TCTTCCTGCGACCGGGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6210192010307249					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171471	8171521	8018875	8018925	16334	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-13				GGGTGCTTGTCTTGCTTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15291394928985949					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171384	8171434	8018788	8018838	16335	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-14				GGCTTTTCGAGGCAGTTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33496363857789963					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171647	8171697	8019051	8019101	16336	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-15				CCTTTACGGGGAAACAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13072439680049039					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171599	8171649	8019003	8019053	16337	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-16				ACGCCTGAGGGGGCGCTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1244477578384561					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171672	8171722	8019076	8019126	16338	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-17				ACGGCGGCGCCAAGGGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4238446185956819					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171933	8171983	8019337	8019387	16339	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-18				ATCATCCCCTGCTGCCCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45993697804158179					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171507	8171557	8018911	8018961	16340	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-19				GCAGGGGTCCGGCTCGCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54252023500348068					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171518	8171568	8018922	8018972	16341	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-2				GCTCGCGGTCGGGGTTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27511203014519769					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171819	8171869	8019223	8019273	16342	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-20				GATCAGGCAAAGAGTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26526486045328429					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171542	8171592	8018946	8018996	16343	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-21				TGCGCAGGTGAGAAGCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076215261327356273					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171886	8171936	8019290	8019340	16344	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-22				TCTATAGAGTCTTTTCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56411324797706741					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171557	8171607	8018961	8019011	16345	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-23				GGCTGGACCGTGTGGTGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51854632763218489					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171489	8171539	8018893	8018943	16346	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-24				CACCCACCTGCGGTCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1087189329752575					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171900	8171950	8019304	8019354	16347	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-25				CTCTATAGAGTTTTGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35624911897879041					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171962	8172012	8019366	8019416	16348	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-26				TGTCTGCAGGGGCCTTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8329809597107616					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171737	8171787	8019141	8019191	16349	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-27				CCTCACCGCCTGCGGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.146780447952169					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171578	8171628	8018982	8019032	16350	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-28				GGGATCCCCTGCAGCCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31155254331367122					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171871	8171921	8019275	8019325	16351	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-29				CCGCAGTTCTCTCCACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37005728714359137					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171428	8171478	8018832	8018882	16352	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-3				ACGTTTTGCGACCACATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.096114390578137893					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171803	8171853	8019207	8019257	16353	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-30				AGAAGGCTCAGGGTGAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14248648462599511					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171363	8171413	8018767	8018817	16354	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-31				GGTCCCAGCGGCTGCGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058259797873881289					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171788	8171838	8019192	8019242	16355	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-32				AGCCTTCTTCCCAGCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061966806133150629					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171748	8171798	8019152	8019202	16356	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-33				GCGGCAGGGAGGTGGTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53164685974090431					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171345	8171395	8018749	8018799	16357	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-34				CGGGGCCGGCGGGAGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99412464146305923					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171838	8171888	8019242	8019292	16358	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-4				TCGGACTCACGAGCTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28386281839343042					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171635	8171685	8019039	8019089	16359	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-5				GGGAGAGGGAACCCTTTACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22215139532518791					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171948	8171998	8019352	8019402	16360	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-6				TTACCCTGGATGGCACCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22102934938265589					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171610	8171660	8019014	8019064	16361	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-7				GTCGCAGGAAGACGCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097167912800113512					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171417	8171467	8018821	8018871	16362	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-8				CTTTGAATGGTCCGTTAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29242702485268413					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8171444	8171494	8018848	8018898	16363	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-8-9				AAAACGTGACTCGGTTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37025317474739949					SLC2A3	chr12	7919229	8019007	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179289	8179339	8026693	8026743	16364	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-1				ATCACAGGATGACGCACGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39521120896759709					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179275	8179325	8026679	8026729	16365	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-10				CACGCGAGGGGTGGTATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3466156656176646					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179359	8179409	8026763	8026813	16366	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-11				CCGAACCCCAGCCAATTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20780660059237971					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179841	8179891	8027245	8027295	16367	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-12				GCTGCTGGGCCTCTACCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52708966433028615					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179572	8179622	8026976	8027026	16368	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-13				GGACACGTCCTACTGAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43623081993903812					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179779	8179829	8027183	8027233	16369	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-14				GCCGAGTGCTTGCTCGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47626181284099672					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179550	8179600	8026954	8027004	16370	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-15				GGGCCGGGTACGTGGGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84866751686349218					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179550	8179600	8026954	8027004	16371	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-15				GGGCCGGGTACGTGGGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84866751686349218					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179739	8179789	8027143	8027193	16372	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-16				CAGCTCCGGCCCGGGAACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24878096045386561					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179704	8179754	8027108	8027158	16373	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-17				GACGCACTGAATGGAAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0575704026263452					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179227	8179277	8026631	8026681	16374	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-18				CTCCTACCCCAACTACTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5698729070336721					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179127	8179177	8026531	8026581	16375	hg38	N/A	enh2168	N/A	Enhatls38623	enhancer	NANOGe-9-19				CTACATTAACAGAGTCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0011204667179073851					SLC2A3	chr12	7919229	8019007	3403				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179127	8179177	8026531	8026581	16376	hg38	N/A	enh2168	fant40849	Enhatls38623	enhancer	NANOGe-9-19				CTACATTAACAGAGTCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0011204667179073851					FOXJ2	chr12	8032715	8055517	6157				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179127	8179177	8026531	8026581	16377	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-19				CTACATTAACAGAGTCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0011204667179073851					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179469	8179519	8026873	8026923	16378	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-2				ACGACTTTTGCTAACGATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.073025991481592958					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179584	8179634	8026988	8027038	16379	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-20				AGGACGTGTCCTTATCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40061635009795021					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179819	8179869	8027223	8027273	16380	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-21				TAAGGTGGAACAGGAATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1011907480833384					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179644	8179694	8027048	8027098	16381	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-22				TCACACGCTCCTCCCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16478118077678161					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179097	8179147	8026501	8026551	16382	hg38	N/A	enh2168	N/A	Enhatls38623	enhancer	NANOGe-9-23				TTTCCGTGTTTCAATCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46362682903377911					SLC2A3	chr12	7919229	8019007	3403				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179097	8179147	8026501	8026551	16383	hg38	N/A	enh2168	fant40849	Enhatls38623	enhancer	NANOGe-9-23				TTTCCGTGTTTCAATCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46362682903377911					FOXJ2	chr12	8032715	8055517	6157				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179146	8179196	8026550	8026600	16384	hg38	N/A	enh2168	fant40849	Enhatls38623	enhancer	NANOGe-9-24				GTTTGCCATTCTCTCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.448425882472637					FOXJ2	chr12	8032715	8055517	6157				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179146	8179196	8026550	8026600	16385	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-24				GTTTGCCATTCTCTCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.448425882472637					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179752	8179802	8027156	8027206	16386	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-25				GCCGGAGCTGACACGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	11.77659203394092					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179407	8179457	8026811	8026861	16387	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-26				GGAAAACTTGCCACCTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1083663586607462					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179165	8179215	8026569	8026619	16388	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-27				AAACAGACCCTTCCCTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43556914626227461					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179539	8179589	8026943	8026993	16389	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-28				GTGGGCCATGGGGCCCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034211744397232943					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179539	8179589	8026943	8026993	16390	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-28				GTGGGCCATGGGGCCCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034211744397232943					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179613	8179663	8027017	8027067	16391	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-29				AGAAAGGAACCCAACCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.091826536810069					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179327	8179377	8026731	8026781	16392	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-3				GCCCAAGATCGCTTGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28401584079914111					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179526	8179576	8026930	8026980	16393	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-30				CCAAGACCCCACCCCAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40946295091522628					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179526	8179576	8026930	8026980	16394	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-30				CCAAGACCCCACCCCAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40946295091522628					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179882	8179932	8027286	8027336	16395	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-31				AAAAACTGGGAGGCGAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46837129839771791					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179679	8179729	8027083	8027133	16396	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-32				CAGGAGAGACCTGCTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20430264116357971					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179597	8179647	8027001	8027051	16397	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-33				ATCCCTGAGGTCCTCCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069746609328607836					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179382	8179432	8026786	8026836	16398	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-34				AAGATGAAGAATTGGGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70813338514646462					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179083	8179133	8026487	8026537	16399	hg38	N/A	enh2168	N/A	Enhatls38623	enhancer	NANOGe-9-35				ACACGGAAATGAGTTTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082150238345228346					SLC2A3	chr12	7919229	8019007	3403				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179083	8179133	8026487	8026537	16400	hg38	N/A	enh2168	fant40849	Enhatls38623	enhancer	NANOGe-9-35				ACACGGAAATGAGTTTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082150238345228346					FOXJ2	chr12	8032715	8055517	6157				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179253	8179303	8026657	8026707	16401	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-36				GGAGGAAGTGAGGATTATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.026062816416671					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179856	8179906	8027260	8027310	16402	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-37				CAGGGGCCGGCACATCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.802018640319629					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179506	8179556	8026910	8026960	16403	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-38				TGGGGAGACAGAACTGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.017833464546709369					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179506	8179556	8026910	8026960	16404	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-38				TGGGGAGACAGAACTGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.017833464546709369					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179178	8179228	8026582	8026632	16405	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-39				GACATAAAAATGTCCACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28841385210240372					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179628	8179678	8027032	8027082	16406	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-4				CGTGTGAAGCACGGGCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.046117899503535037					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179423	8179473	8026827	8026877	16407	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-40				CTTTTGGAAATGATTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37085253550818381					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179370	8179420	8026774	8026824	16408	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-41				TTCTTCATCTTCCTCTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1277200151819306					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179065	8179115	8026469	8026519	16409	hg38	N/A	enh2168	N/A	Enhatls38623	enhancer	NANOGe-9-42				AAAGGAACTGAAGGAAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1992000841155279					SLC2A3	chr12	7919229	8019007	3403				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179869	8179919	8027273	8027323	16410	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-43				CGAGGTTGGGAAGCAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2438271287769962					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179440	8179490	8026844	8026894	16411	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-5				AAGAGGTGCGTCCGGAACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17901616206320151					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179451	8179501	8026855	8026905	16412	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-6				GTCGTAAGTTTCCCTCGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40718368747369837					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179655	8179705	8027059	8027109	16413	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-7				TCCCCGCGCCGGTGGAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3801112970402471					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179804	8179854	8027208	8027258	16414	hg38	N/A	N/A	N/A	Enhatls38623	enhancer	NANOGe-9-8				GAGGCGAAAGCTTCTTAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095198918503046667					FOXJ2	chr12	8032715	8055517	4952				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-35582	chr12	8179304	8179354	8026708	8026758	16415	hg38	N/A	N/A	fant40849	Enhatls38623	enhancer	NANOGe-9-9				CTGCGTTGGTAATCTATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72564234688959139					FOXJ2	chr12	8032715	8055517	5761				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	892
enhrx-lit200	chr12	7940542	7940592	7787946	7787996	16416	hg38					enhancer	NANOGe+1-1				GCAGATAGTCTATGTCTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.19337128521301													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit201	chr12	7940585	7940635	7787989	7788039	16417	hg38					enhancer	NANOGe+1-10				GCATCAGGGAGCCGGTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6089663373261138													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit202	chr12	7940300	7940350	7787704	7787754	16418	hg38					enhancer	NANOGe+1-11				GGCTCTTACCCTAGACACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2964391219333511													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit203	chr12	7940158	7940208	7787562	7787612	16419	hg38					enhancer	NANOGe+1-12				TTTTGGAACAGGCTGGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.185420516283103													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit204	chr12	7940454	7940504	7787858	7787908	16420	hg38					enhancer	NANOGe+1-13				TTGTTAAGTGGGGGCTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.308932052433201													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit205	chr12	7940169	7940219	7787573	7787623	16421	hg38					enhancer	NANOGe+1-14				GACTTTAGATTTTTTGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1757241497174595													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit206	chr12	7940466	7940516	7787870	7787920	16422	hg38					enhancer	NANOGe+1-15				AATCAGCACAGTTTGTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.320779975271106													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit207	chr12	7940481	7940531	7787885	7787935	16423	hg38					enhancer	NANOGe+1-16				TGCTGATTAAGAGAGACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2640891809760619													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit208	chr12	7940418	7940468	7787822	7787872	16424	hg38					enhancer	NANOGe+1-17				GCTGCGGGCAAGCTCAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41399201355809911													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit209	chr12	7940392	7940442	7787796	7787846	16425	hg38					enhancer	NANOGe+1-18				AGCTTCTGGTACCTGCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.47810751182719													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit210	chr12	7940314	7940364	7787718	7787768	16426	hg38					enhancer	NANOGe+1-19				ACACAATGGGACAGGGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.3241187672610684													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit211	chr12	7940574	7940624	7787978	7788028	16427	hg38					enhancer	NANOGe+1-2				GATGTACTAGCCCCACTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.127556730476825													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit212	chr12	7940335	7940385	7787739	7787789	16428	hg38					enhancer	NANOGe+1-20				GGGATGGGGGAATTCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.355802858637376													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit213	chr12	7940378	7940428	7787782	7787832	16429	hg38					enhancer	NANOGe+1-21				TCTGCAAAGAACAAAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9914210824423511													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit214	chr12	7940201	7940251	7787605	7787655	16430	hg38					enhancer	NANOGe+1-22				TTGGAATAAAGTTGAGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.3647299176640884													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit215	chr12	7940263	7940313	7787667	7787717	16431	hg38					enhancer	NANOGe+1-23				AGCCACCAGCCCCTTCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.741514877621539													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit216	chr12	7940514	7940564	7787918	7787968	16432	hg38					enhancer	NANOGe+1-24				GGATGATTTCTTTAAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43450026552871479													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit217	chr12	7940231	7940281	7787635	7787685	16433	hg38					enhancer	NANOGe+1-3				ACTTACTACATTCTTCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78196984509935985													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit218	chr12	7940599	7940649	7788003	7788053	16434	hg38					enhancer	NANOGe+1-4				GATTAAGCATAGGGGCATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6371134884103373													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit219	chr12	7940279	7940329	7787683	7787733	16435	hg38					enhancer	NANOGe+1-5				CCTTTGGTCTTTCACTCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.227031684854885													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit220	chr12	7940220	7940270	7787624	7787674	16436	hg38					enhancer	NANOGe+1-6				TCTTCGCCAAGGAAAGCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.7973699410255124													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit221	chr12	7940435	7940485	7787839	7787889	16437	hg38					enhancer	NANOGe+1-7				AAGGCCACCAAGACTCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.34753229041609													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit222	chr12	7940407	7940457	7787811	7787861	16438	hg38					enhancer	NANOGe+1-8				CTTGCCCGCAGCTCTCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3958694007258949													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit223	chr12	7940131	7940181	7787535	7787585	16439	hg38					enhancer	NANOGe+1-9				GTTAAAATGAGCTAACGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.334297129428264													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35351	chr12	6873359	6873409	6764193	6764243	16440	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-1				TGGGACCACCAGGGTTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0036193508668679081					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873399	6873449	6764233	6764283	16441	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-10				TCACCCTTCCATAAGGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2408396775043653					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873373	6873423	6764207	6764257	16442	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-11				GTGGTCCCAGTTAGAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079660670679903955					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873427	6873477	6764261	6764311	16443	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-12				AGTGTCCCAGCCTCTCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47595764529730189					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873526	6873576	6764360	6764410	16444	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-13				ATAAGGCAGGGCAAGCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42349677548611708					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873636	6873686	6764470	6764520	16445	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-14				AGGTTGTTGGTGGCGGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38475021290141209					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873602	6873652	6764436	6764486	16446	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-15				TGGCTATCAGGAAAAATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32812010663815477					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873707	6873757	6764541	6764591	16447	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-16				CAACAGGGTAAGAGCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033956919026024678					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873806	6873856	6764640	6764690	16448	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-17				AGTCTCGCTCCCTCCCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75408474134966552					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873829	6873879	6764663	6764713	16449	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-18				GGGAGACTGGGTTGTTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82579954197872529					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873669	6873719	6764503	6764553	16450	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-19				GGAGTGGAGGTGACCGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.041532694466669733					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873260	6873310	6764094	6764144	16451	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-2				GGAGCCGGGAATTTTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51157834905228838					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873339	6873389	6764173	6764223	16452	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-20				TGGGCTGTGGGCCGGACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32882096987316539					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873466	6873516	6764300	6764350	16453	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-21				TGGAGGGGCTGGTCCCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31321359554107892					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873734	6873784	6764568	6764618	16454	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-22				CCGAGACAGCAGGCGGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24675354991493309					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873297	6873347	6764131	6764181	16455	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-23				GTGGGAATGAGGTGTGATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.057944834236503					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873478	6873528	6764312	6764362	16456	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-24				TCCCCTGTGGGGCTGGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.620027939799026					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873817	6873867	6764651	6764701	16457	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-25				GGGAGCGAGACTGGGAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52349623879963					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873450	6873500	6764284	6764334	16458	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-26				CGGGGAGAAGGGACACTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33746525221364221					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873248	6873298	6764082	6764132	16459	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-27				TTTGCCCAGGGAGGGGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44012742002376248					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873327	6873377	6764161	6764211	16460	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-28				CGGACTGTGGGCTGGGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57245309681632539					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873204	6873254	6764038	6764088	16461	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-29				AAAATTCCAGAGAGATGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86022241247336306					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873513	6873563	6764347	6764397	16462	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-3				CTCACATCCCCATATAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5457808623051067					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873793	6873843	6764627	6764677	16463	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-30				GGAGAGGAAAGAGCCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34616182519771771					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873648	6873698	6764482	6764532	16464	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-31				GCGGTGATTGGAGGGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1912125916748053					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873282	6873332	6764116	6764166	16465	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-32				GATTAGGGAAGGGGAGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7745628207754629					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873616	6873666	6764450	6764500	16466	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-33				AATAGGAGGAAGGTGGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52599347067590019					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873311	6873361	6764145	6764195	16467	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-34				CATTCCCACCCCCAGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20963816001852731					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873193	6873243	6764027	6764077	16468	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-35				GAGATGGAGAGGCAGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062601493125297392					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873227	6873277	6764061	6764111	16469	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-36				GGGAGCAGAGGCAGCTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2462171635398854					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873749	6873799	6764583	6764633	16470	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-37				GGGCTGGGAGGTGGAGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0440492200419129					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873771	6873821	6764605	6764655	16471	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-38				GAAGAGGAAAGGAAGGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.109806547734864					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873760	6873810	6764594	6764644	16472	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-39				TGGAGTGGAGGGAAGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66233328625509458					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873572	6873622	6764406	6764456	16473	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-4				GAGCATTCCACCTGGCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43721357355222529					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873590	6873640	6764424	6764474	16474	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-5				CAGGGTTTCTATTGGCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42860754516456651					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873538	6873588	6764372	6764422	16475	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-6				AAGCAGTTAGGCTTCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1114056474720761					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873692	6873742	6764526	6764576	16476	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-7				GGGCGGTTACCAGGGCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.010953543897824941					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873439	6873489	6764273	6764323	16477	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-8				TCTCTTTAGGGCGGGGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34828072852068981					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35351	chr12	6873721	6873771	6764555	6764605	16478	hg38	N/A	enh14496	fant40813	N/A	enhancer	NANOGe+10-9				GCTGTCTCGGACACCCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091231001030445485					MLF2	chr12	6747995	6767475	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	661
enhrx-35203	chr12	6324192	6324242	6215026	6215076	16479	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-1				TGCGGCATTGTGACCATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40111710267779					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324495	6324545	6215329	6215379	16480	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-10				TCATTTACACACCAATAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34761789971551288					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324211	6324261	6215045	6215095	16481	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-11				CGCATTTCCAGGGTGACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22176361371554759					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324285	6324335	6215119	6215169	16482	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-12				ACACTCCGATCTGGAGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13710377930196521					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324241	6324291	6215075	6215125	16483	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-13				TGACCAGCACTGTGAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.443104030637163					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324227	6324277	6215061	6215111	16484	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-14				AGCCACGGGGAGGGAACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77890201390239555					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324319	6324369	6215153	6215203	16485	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-15				TGCCAGTCCTGCTCCCTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074200629347879257					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324436	6324486	6215270	6215320	16486	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-16				GCATTTAGAAAGCTATTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.37665085267669					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324593	6324643	6215427	6215477	16487	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-17				AGTGAAACTGGAGTGGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58950053140748537					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324668	6324718	6215502	6215552	16488	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-18				AATGACCCCAGACCAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1689731497378702					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324511	6324561	6215345	6215395	16489	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-19				TAAATGAAGGCCTAGAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0873195864617651					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324771	6324821	6215605	6215655	16490	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-2				TCTACCGAGCCACTGTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10334482233936219					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324562	6324612	6215396	6215446	16491	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-20				CTGTTTTCCAACACCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2353070108106195					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324400	6324450	6215234	6215284	16492	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-21				CACCTCCCATCCATGCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38009524317679488					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324381	6324431	6215215	6215265	16493	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-22				GGTGTGAGCTTCCTCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32455383238122348					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324359	6324409	6215193	6215243	16494	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-23				GAGGTGCTTTGTGTGTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22119289441833559					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324651	6324701	6215485	6215535	16495	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-24				AGCAGGATGACCCAGGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26208063051904051					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324707	6324757	6215541	6215591	16496	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-25				TGGCATAGAGAAGAGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4862660999167957					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324179	6324229	6215013	6215063	16497	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-26				CTCTGCATCCTCACCCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1129512007637381					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324484	6324534	6215318	6215368	16498	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-27				TCTCTGTCCTTCCTGATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54487974829726271					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324104	6324154	6214938	6214988	16499	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-28				TGTGCTGAACCCACTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1109926873867773					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324370	6324420	6215204	6215254	16500	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-29				ACAAAGCACCTCCAGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3525091887427379					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324296	6324346	6215130	6215180	16501	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-3				AGATCGGAGTGTAAAGTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16889210225665441					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324470	6324520	6215304	6215354	16502	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-30				GGACAGAGAAAAGCTCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083566329189748767					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324332	6324382	6215166	6215216	16503	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-31				CTCACTGCCCAGCCCCACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054309117707740683					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324737	6324787	6215571	6215621	16504	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-32				TTGAAGATAAGAATTTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0333202685030809					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324164	6324214	6214998	6215048	16505	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-33				ATGCAGAGAGGTGGGAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46347570917544773					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324134	6324184	6214968	6215018	16506	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-34				AAGAAAGGAGAGAGAACGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49729782439313353					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324149	6324199	6214983	6215033	16507	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-35				AAGGCAGGAAGAGGTAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38533249859321739					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324633	6324683	6215467	6215517	16508	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-4				AACTGCGAATTTGCATGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26287489354433452					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324682	6324732	6215516	6215566	16509	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-5				GGGGTCATTTCGAGAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1704140201611824					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324415	6324465	6215249	6215299	16510	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-6				GCCAGTGCCGAAAAGCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0036756505428263931					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324544	6324594	6215378	6215428	16511	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-7				TGAGCGTGATGAGAGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32814500424776177					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324605	6324655	6215439	6215489	16512	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-8				CTAGACTCACTCAGTGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83092619056484773					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6324725	6324775	6215559	6215609	16513	hg38	N/A	enh14491	N/A	Enhatls38205	enhancer	NANOGe+11-9				CTTATCTTCAAAGGCAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070177328606436079					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314597	6314647	6205431	6205481	16514	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-1				AAGCACTCCCAAATTCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053854011766673607					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314662	6314712	6205496	6205546	16515	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-10				GATGAGCCCTCTGCGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69921238436965849					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314617	6314667	6205451	6205501	16516	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-11				CTTTGATATGCAGCCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33896569330562931					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314458	6314508	6205292	6205342	16517	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-12				AAGACCCAATCTTTTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047727705612616092					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314631	6314681	6205465	6205515	16518	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-13				GTACTGGCAGGGCCCCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6076420443755932					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314424	6314474	6205258	6205308	16519	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-14				CTCTCCCCTACACCCACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20749097228573729					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314808	6314858	6205642	6205692	16520	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-15				CTGTTCTGTTCAATTTTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034357989947916077					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314572	6314622	6205406	6205456	16521	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-16				TGCTCAGAGGAAGCAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52363903610544549					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314697	6314747	6205531	6205581	16522	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-17				GCCTTCTCACCCCTTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5655587450569319					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314760	6314810	6205594	6205644	16523	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-18				AAAGCAGACAAAACAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.237033702121821					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314489	6314539	6205323	6205373	16524	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-19				GTGAGTGTGAGCGTGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024616509802073871					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314647	6314697	6205481	6205531	16525	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-2				GGCTCATCTAGAGTCAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15873910770990871					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314522	6314572	6205356	6205406	16526	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-3				GTGGGCCACGTTGAAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21311835407728261					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314540	6314590	6205374	6205424	16527	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-4				AGGGTCTGGAATCGTGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027907226068537669					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314436	6314486	6205270	6205320	16528	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-5				TTGTTGTTCACACCCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.178296796229986					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314712	6314762	6205546	6205596	16529	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-6				TCATCCAACACTGCTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26615334214108671					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314742	6314792	6205576	6205626	16530	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-7				ACAGGATCTATGTGTGTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18044633353092071					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314407	6314457	6205241	6205291	16531	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-8				GGAGAGACCATCAAAATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93340771319997429					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-35203	chr12	6314559	6314609	6205393	6205443	16532	hg38	N/A	N/A	N/A	Enhatls38205	enhancer	NANOGe+12-9				CCCTGCTCTATTGTGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093792531315817412					CD9	chr12	6199714	6238271	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	513
enhrx-lit224	chr12	7862862	7862912	7710266	7710316	16533	hg38					enhancer	NANOGe+2-1				GCTTGTTAAAGCATTACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29327930235913519													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit225	chr12	7862770	7862820	7710174	7710224	16534	hg38					enhancer	NANOGe+2-10				AGTTAAGCAGCCCTGCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57142135586615272													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit226	chr12	7862577	7862627	7709981	7710031	16535	hg38					enhancer	NANOGe+2-11				CTCTCATTTGTAAAAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28143608299800132													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit227	chr12	7862611	7862661	7710015	7710065	16536	hg38					enhancer	NANOGe+2-12				TAGGAGGTGAGATAACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48022252097014761													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit228	chr12	7862733	7862783	7710137	7710187	16537	hg38					enhancer	NANOGe+2-13				TACTTCTGTTGTTCAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01034115087314324													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit229	chr12	7862927	7862977	7710331	7710381	16538	hg38					enhancer	NANOGe+2-14				TTTGTATATCTAAGTTAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit230	chr12	7862645	7862695	7710049	7710099	16539	hg38					enhancer	NANOGe+2-15				ATACAAAAAAATCCCATTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048841265206168133													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit231	chr12	7862981	7863031	7710385	7710435	16540	hg38					enhancer	NANOGe+2-16				AGGGCAGGACCCTGCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.004988334021494													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit232	chr12	7862795	7862845	7710199	7710249	16541	hg38					enhancer	NANOGe+2-17				AGCACCCATCAGAATCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26625280857005151													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit233	chr12	7862497	7862547	7709901	7709951	16542	hg38					enhancer	NANOGe+2-18				ATTGCTTGAAGCCAGGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077079167225867648													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit234	chr12	7862967	7863017	7710371	7710421	16543	hg38					enhancer	NANOGe+2-19				ACTTTTTTTTTTTTCCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27882163037761992													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit235	chr12	7862759	7862809	7710163	7710213	16544	hg38					enhancer	NANOGe+2-2				AGTTCACAGTGCCGTAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53338593997481509													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit236	chr12	7862564	7862614	7709968	7710018	16545	hg38					enhancer	NANOGe+2-20				AAAACCTAGGCTGGGCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.236642313257573													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit237	chr12	7862486	7862536	7709890	7709940	16546	hg38					enhancer	NANOGe+2-21				CCAGGTTAGTCCCGAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43480103657545333													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit238	chr12	7862526	7862576	7709930	7709980	16547	hg38					enhancer	NANOGe+2-22				GCCTTAGCCTCCCAAAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32893355570321858													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit239	chr12	7862633	7862683	7710037	7710087	16548	hg38					enhancer	NANOGe+2-3				AATCCTAAACCCCCTGCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.09058220247659321													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit240	chr12	7862886	7862936	7710290	7710340	16549	hg38					enhancer	NANOGe+2-4				CGCCAGTCTTTGATTCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0126558578050629													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit241	chr12	7862837	7862887	7710241	7710291	16550	hg38					enhancer	NANOGe+2-5				GGCTAAATGCAGAATTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021351079900070631													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit242	chr12	7862676	7862726	7710080	7710130	16551	hg38					enhancer	NANOGe+2-6				TCAGTCCGCAAGAATTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60541124824784986													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit243	chr12	7862713	7862763	7710117	7710167	16552	hg38					enhancer	NANOGe+2-7				TGGCTAATCTCCCTCTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27840422147999089													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit244	chr12	7862808	7862858	7710212	7710262	16553	hg38					enhancer	NANOGe+2-8				ATCACCTGGGGATCACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1023286859599593													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit245	chr12	7862695	7862745	7710099	7710149	16554	hg38					enhancer	NANOGe+2-9				CTGATTATCAGAGATTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24433798014592231													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit246	chr12	7862537	7862587	7709941	7709991	16555	hg38					enhancer	NANOGe+2/SOX17e-21				CGCCTGTAATCCCAGCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1532658048077868													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35540	chr12	7847592	7847642	7694996	7695046	16556	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-1				GTAGCCAGGAGGTACAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1503808343186816					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847608	7847658	7695012	7695062	16557	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-10				AATAAGGGAAGCAGGACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35046974322202012					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847209	7847259	7694613	7694663	16558	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-11				TCAAGGCCATACACAGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56108614623054354					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847497	7847547	7694901	7694951	16559	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-12				TTAAAAGGATCTCAGTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78364214663119947					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847427	7847477	7694831	7694881	16560	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-13				GTTGGAGGATCTACTGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21389167117485891					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847383	7847433	7694787	7694837	16561	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-14				CTTTGAATAAGAATTGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.104456963715072					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847308	7847358	7694712	7694762	16562	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-15				AGATGCAGAATTTAGAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2594947527709332					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847372	7847422	7694776	7694826	16563	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-16				TCTTATTCAAAGTCTGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38055277526148112					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847512	7847562	7694916	7694966	16564	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-17				AACTGTCATATCCTTTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1388612940147631					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847192	7847242	7694596	7694646	16565	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-18				AACTTTATCTTGTATTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4519719885061821					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847409	7847459	7694813	7694863	16566	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-19				ACTAGGGGCAGGAATGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9101267074444914					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847454	7847504	7694858	7694908	16567	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-2				GACCACCCACCAAATAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54812707248829806					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847220	7847270	7694624	7694674	16568	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-20				CACAGTTCCTGGCTCACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28029252688094219					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847338	7847388	7694742	7694792	16569	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-3				TGCATGTCTATACAACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1048904017359836					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847578	7847628	7694982	7695032	16570	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-4				GCCACCCAACAAGAGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3515799492896291					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847236	7847286	7694640	7694690	16571	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-5				AAGCACTTATTGGATACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045007420182426837					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847394	7847444	7694798	7694848	16572	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-6				AATTGGGTGGGGAGAACTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59797645366416741					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847289	7847339	7694693	7694743	16573	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-7				TTGGTTAGTTTTACAGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53678265127067537					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847472	7847522	7694876	7694926	16574	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-8				TGGTCAGTTTGGGAAAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24692344583050521					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35540	chr12	7847323	7847373	7694727	7694777	16575	hg38	N/A	N/A	N/A	Enhatls38579	enhancer	NANOGe+3-9				CTGCATCTGAAACACCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1187652133422501					GDF3	chr12	7689783	7695775	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	850
enhrx-35518	chr12	7592779	7592829	7440183	7440233	16576	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-1				CGAGTGTTAAGTGTCCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13691101397095889					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592779	7592829	7440183	7440233	16577	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-1				CGAGTGTTAAGTGTCCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13691101397095889					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592695	7592745	7440099	7440149	16578	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-10				GGCGGGTCCAAGCCCGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08757759156628285					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592846	7592896	7440250	7440300	16579	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-11				GGGCGCTCCTGAGCTTCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.239752947638521					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592723	7592773	7440127	7440177	16580	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-12				AGCGTGGCCACGTCCCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29513367059310242					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592951	7593001	7440355	7440405	16581	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-13				GCTTCCCGTGCGGCGGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.29193715132944					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592868	7592918	7440272	7440322	16582	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-14				CAGTCCGCCCTCCCCGTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.179820768122655					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592651	7592701	7440055	7440105	16583	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-15				ATGTGGAGTAGGGCGGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1145765604144859					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592496	7592546	7439900	7439950	16584	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-16				GAGTTGGCCGAAGTCGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8395113457601617					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592834	7592884	7440238	7440288	16585	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-17				GCTTCGCGGGGCCGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26944774203797928					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592891	7592941	7440295	7440345	16586	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-18				CGCAGTGCCGCGCCCGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49290699040198632					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592523	7592573	7439927	7439977	16587	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-19				GTGCTGTCGGCAGCTGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5655132207312654					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592791	7592841	7440195	7440245	16588	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-2				CTTAACACTCGCGTCGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43365365791061361					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592791	7592841	7440195	7440245	16589	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-2				CTTAACACTCGCGTCGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43365365791061361					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592581	7592631	7439985	7440035	16590	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-20				GGTTTGCGGAGCTGCTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7277427276853716					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592512	7592562	7439916	7439966	16591	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-21				TGCCGACAGCACTGAGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5909317028799874					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592756	7592806	7440160	7440210	16592	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-22				TGCTCTTGGCTCCGGGTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36051722490811861					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592756	7592806	7440160	7440210	16593	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-22				TGCTCTTGGCTCCGGGTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36051722490811861					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592820	7592870	7440224	7440274	16594	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-23				CTCCGCGCAGGCAGCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15959729443573639					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592737	7592787	7440141	7440191	16595	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-24				AGCAGGCGGCGGAGCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.274187297483288					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592615	7592665	7440019	7440069	16596	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-25				GCTGGGGTGTGTGTCGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18147854166263239					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592476	7592526	7439880	7439930	16597	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-26				AGGAGTTGGAGTAGTGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1223399515604652					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592569	7592619	7439973	7440023	16598	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-27				TGCTAGGATGGAGCAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4671605960563019					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592808	7592858	7440212	7440262	16599	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-28				CCGCGGCCGGCCCTCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34448757931151791					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592903	7592953	7440307	7440357	16600	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-29				GCGGCTCCAGGTCCCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.07288712363873					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592707	7592757	7440111	7440161	16601	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-3				TTGGACCCGCCGCGCCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079564450733341938					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592916	7592966	7440320	7440370	16602	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-30				CTGGAGCCGCCGCCGCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1648653466928468					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592931	7592981	7440335	7440385	16603	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-31				GGGATGGCGGCAGGGCCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32917863718873991					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592682	7592732	7440086	7440136	16604	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-4				TAACGGAAGCCGACCAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.254020277130957					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592668	7592718	7440072	7440122	16605	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-5				CTTCCGTTACGCCGCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4170052187658122					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592632	7592682	7440036	7440086	16606	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-6				GCGGAACGCGAGGAGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33742170405344007					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592857	7592907	7440261	7440311	16607	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-7				TCAGGAGCGCCCCTGCGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2185791170795606					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592595	7592645	7439999	7440049	16608	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-8				GGGTTTTCCTCGGCGGTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.070724646526741583					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592767	7592817	7440171	7440221	16609	hg38	N/A	enh107527	fant40826	Enhatls38557	enhancer	NANOGe+4-9				GTCCGCCCTGGCCGGCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32153507953828342					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35518	chr12	7592767	7592817	7440171	7440221	16610	hg38	N/A	enh107527	N/A	Enhatls38557	enhancer	NANOGe+4-9				GTCCGCCCTGGCCGGCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32153507953828342					CD163L1	chr12	7346684	7479897	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	828
enhrx-35490	chr12	7434225	7434275	7281629	7281679	16611	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-1				GATAATCCTCATTCCTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.106788505501739					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434347	7434397	7281751	7281801	16612	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-10				CTCTGAAGTCTGCTACCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13109604686213661					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434523	7434573	7281927	7281977	16613	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-11				TGTAATCCCAGCCAGTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33764410311716753					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434485	7434535	7281889	7281939	16614	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-12				CACTTGAACCCGGGAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.62639932378273					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434544	7434594	7281948	7281998	16615	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-13				CAGGCATGTGCCACCATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.192029362717584					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434305	7434355	7281709	7281759	16616	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-2				TCTTATCAGACTTAAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4834622236310307					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434398	7434448	7281802	7281852	16617	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-3				AATAAAAAGATAAGGGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3871188127492351					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434512	7434562	7281916	7281966	16618	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-4				TCATGCCTCAGCCTCCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65665291766590728					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434451	7434501	7281855	7281905	16619	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-5				TGAAGTGCAGTGGTGCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.742039111690217					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434261	7434311	7281665	7281715	16620	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-6				TTGTTTTTTTTTCCTGATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36206926395769429					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434372	7434422	7281776	7281826	16621	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-7				TCATCTGCATAATAAAACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38521156435866211					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434238	7434288	7281642	7281692	16622	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-8				AAACAAAAAAAAACCTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.5263075400287978					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35490	chr12	7434279	7434329	7281683	7281733	16623	hg38	N/A	N/A	N/A	Enhatls38529	enhancer	NANOGe+5-9				ACTCTTAGTTAATTCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64712940203632574					ACSM4	chr12	7304071	7328719	12243				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	800
enhrx-35442	chr12	7145255	7145305	7037951	7038001	16624	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6				ACAAACCTTGAGCTAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18870602308752579					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145244	7145294	7037940	7037990	16625	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6				GCTAAACACAGGGTGCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65646946366069525					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145326	7145376	7038022	7038072	16626	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-1				GAGAACCTTTATGTCTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40004217857193491					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145575	7145625	7038271	7038321	16627	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-10				AATCAGCGCCCTGACAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097782996317468215					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145445	7145495	7038141	7038191	16628	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-11				GCTAGATAGAGAGTGTCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55142334178330532					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145363	7145413	7038059	7038109	16629	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-12				GCTAGATACACAGTGCCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14440801361687611					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145208	7145258	7037904	7037954	16630	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-13				AGAGCCTTTATGTCTAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31724093006418652					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145285	7145335	7037981	7038031	16631	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-14				GCTAGATACACAGTGTCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69484184300367235					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145160	7145210	7037856	7037906	16632	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-15				ATCTACTAGGTGAAGCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018775169304328109					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145137	7145187	7037833	7037883	16633	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-16				TTCACCTGCAGCCCCGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024319934320914831					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145106	7145156	7037802	7037852	16634	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-2				GCAAGCGCACTGCACGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1971720301244215					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145073	7145123	7037769	7037819	16635	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-22				CCAGTCCCATCGACCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.23704763798933					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145541	7145591	7038237	7038287	16636	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-3				AATCCCTGAGCTAGATATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29308189091845033					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145491	7145541	7038187	7038237	16637	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-4				GATGCAGAGTTTCGACACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089271344570918051					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145148	7145198	7037844	7037894	16638	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-5				ACCTAGTAGATCCCGCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38202984636004322					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145090	7145140	7037786	7037836	16639	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-6				CGCTTGCACTCCTCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1857305402716678					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145296	7145346	7037992	7038042	16640	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-7				TGTGTATCTAGCTGCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23909356718356919					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145456	7145506	7038152	7038202	16641	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-8				TCTCTATCTAGCTGCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88606507207891028					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145506	7145556	7038202	7038252	16642	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6-9				TCTGCATCTAACTAATCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.144457862592922					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145348	7145398	7038044	7038094	16643	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6/-16/-17/-23				GGGATTGTAAATACACCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094714161974914488					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145175	7145225	7037871	7037921	16644	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6/EOMESe+16				ACCAGACTCAGGAGCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40077060352798338					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35442	chr12	7145186	7145236	7037882	7037932	16645	hg38	N/A	enh89649	N/A	Enhatls38473	enhancer	NANOGe+6/EOMESe+16				TCCACGTCCCCACCAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1489438476168797					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	752
enhrx-35441	chr12	7104279	7104329	6996187	6996237	16646	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-1				CTGGACCTGCTTAACATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24650664308468281					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104279	7104329	6996187	6996237	16647	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-1				CTGGACCTGCTTAACATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24650664308468281					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104261	7104311	6996169	6996219	16648	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-10				GCCCCAAAGCTTTCCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14308621683103331					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104261	7104311	6996169	6996219	16649	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-10				GCCCCAAAGCTTTCCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14308621683103331					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104219	7104269	6996127	6996177	16650	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-11				CTCTGACTCATCTCTCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21656362435252671					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104219	7104269	6996127	6996177	16651	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-11				CTCTGACTCATCTCTCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21656362435252671					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104383	7104433	6996291	6996341	16652	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-12				CTTATGGTGACATTTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6671253337639087					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104383	7104433	6996291	6996341	16653	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-12				CTTATGGTGACATTTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6671253337639087					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104464	7104514	6996372	6996422	16654	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-13				GTGTGATGGGGGAGGGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14733325289135521					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104464	7104514	6996372	6996422	16655	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-13				GTGTGATGGGGGAGGGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14733325289135521					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104133	7104183	6996041	6996091	16656	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-14				GTGAGAATAGAGGCCTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.802311208128793					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104133	7104183	6996041	6996091	16657	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-14				GTGAGAATAGAGGCCTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.802311208128793					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104475	7104525	6996383	6996433	16658	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-15				GAACAAGAAGTGTGTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26036223418337329					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104475	7104525	6996383	6996433	16659	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-15				GAACAAGAAGTGTGTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26036223418337329					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104182	7104232	6996090	6996140	16660	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-16				GGCAGAGGGACAGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10862003131082219					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104182	7104232	6996090	6996140	16661	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-16				GGCAGAGGGACAGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10862003131082219					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104248	7104298	6996156	6996206	16662	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-17				GCTTTGGGGCTGGAGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72532827021660506					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104248	7104298	6996156	6996206	16663	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-17				GCTTTGGGGCTGGAGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72532827021660506					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104204	7104254	6996112	6996162	16664	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-18				AGTCAGAGGACAGTGGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58740096077847448					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104204	7104254	6996112	6996162	16665	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-18				AGTCAGAGGACAGTGGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58740096077847448					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104119	7104169	6996027	6996077	16666	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-19				CTTGAGAGGGCTTTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31510683234922637					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104119	7104169	6996027	6996077	16667	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-19				CTTGAGAGGGCTTTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31510683234922637					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104119	7104169	6996027	6996077	16668	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-19				CTTGAGAGGGCTTTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31510683234922637					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104119	7104169	6996027	6996077	16669	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-19				CTTGAGAGGGCTTTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31510683234922637					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104394	7104444	6996302	6996352	16670	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-2				TGTCACCATAAGTATCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23702539167154321					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104394	7104444	6996302	6996352	16671	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-2				TGTCACCATAAGTATCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23702539167154321					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104332	7104382	6996240	6996290	16672	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-20				ATCTGTGCAAAGAGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19839694558758811					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104332	7104382	6996240	6996290	16673	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-20				ATCTGTGCAAAGAGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19839694558758811					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104332	7104382	6996240	6996290	16674	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-20				ATCTGTGCAAAGAGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19839694558758811					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104332	7104382	6996240	6996290	16675	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-20				ATCTGTGCAAAGAGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19839694558758811					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104453	7104503	6996361	6996411	16676	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-21				GAGGGTTACAGGGTGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.8613492921836849					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104453	7104503	6996361	6996411	16677	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-21				GAGGGTTACAGGGTGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.8613492921836849					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104318	7104368	6996226	6996276	16678	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-3				TGGTAAGTTCCTTGCCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91030818262598034					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104318	7104368	6996226	6996276	16679	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-3				TGGTAAGTTCCTTGCCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91030818262598034					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104318	7104368	6996226	6996276	16680	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-3				TGGTAAGTTCCTTGCCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91030818262598034					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104318	7104368	6996226	6996276	16681	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-3				TGGTAAGTTCCTTGCCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91030818262598034					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104167	7104217	6996075	6996125	16682	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-4				GGCTGATTGCCAGCACCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074155325885357629					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104167	7104217	6996075	6996125	16683	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-4				GGCTGATTGCCAGCACCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.074155325885357629					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104091	7104141	6995999	6996049	16684	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-5				TCTATTCAACTTAAGTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44639934552339378					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104091	7104141	6995999	6996049	16685	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-5				TCTATTCAACTTAAGTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44639934552339378					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104091	7104141	6995999	6996049	16686	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-5				TCTATTCAACTTAAGTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44639934552339378					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104091	7104141	6995999	6996049	16687	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-5				TCTATTCAACTTAAGTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44639934552339378					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104302	7104352	6996210	6996260	16688	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-6				CTTACCATGTGAAGGCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63559033689893429					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104302	7104352	6996210	6996260	16689	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-6				CTTACCATGTGAAGGCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63559033689893429					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104422	7104472	6996330	6996380	16690	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-7				TATACACTTCTAGATAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15223262438817139					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104422	7104472	6996330	6996380	16691	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-7				TATACACTTCTAGATAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15223262438817139					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104146	7104196	6996054	6996104	16692	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-8				CTATTCTCACTCAGATCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.076800586675825538					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104146	7104196	6996054	6996104	16693	hg38	N/A	enh108516	fant40823	Enhatls38472	enhancer	NANOGe+7-8				CTATTCTCACTCAGATCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.076800586675825538					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104369	7104419	6996277	6996327	16694	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-9				TTACAAAGGACCTGAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40364678382055641					LPCAT3	chr12	6976184	7018476	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-35441	chr12	7104369	7104419	6996277	6996327	16695	hg38	N/A	enh108516	N/A	Enhatls38472	enhancer	NANOGe+7-9				TTACAAAGGACCTGAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40364678382055641					C1S	chr12	6988258	7071032	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	751
enhrx-lit247	chr12	7037035	7037085	6927872	6927922	16696	hg38					enhancer	NANOGe+8-1				GCGGTCCCTCCGAAATGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1074593027716666													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit248	chr12	7036982	7037032	6927819	6927869	16697	hg38					enhancer	NANOGe+8-10				GACGGGCTGGGCGGTGCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1799337028868189													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit249	chr12	7036815	7036865	6927652	6927702	16698	hg38					enhancer	NANOGe+8-11				AAGCCGCGAGGGGGGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35834881047153122													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit250	chr12	7036706	7036756	6927543	6927593	16699	hg38					enhancer	NANOGe+8-12				ATGTGGGGAGCCCGCGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55335672992931928													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit251	chr12	7036781	7036831	6927618	6927668	16700	hg38					enhancer	NANOGe+8-13				GGGGGAGGCGCAGCGCGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83158794059394958													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit252	chr12	7036939	7036989	6927776	6927826	16701	hg38					enhancer	NANOGe+8-14				ACGGCGAAGGGAGGGAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34788613622824549													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit253	chr12	7037010	7037060	6927847	6927897	16702	hg38					enhancer	NANOGe+8-15				CGAGGCCCCGACCCGGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70253969010745643													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit254	chr12	7036733	7036783	6927570	6927620	16703	hg38					enhancer	NANOGe+8-16				GGCGCGGGGAGGGCTAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0043127488818866877													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit255	chr12	7036874	7036924	6927711	6927761	16704	hg38					enhancer	NANOGe+8-17				CGCGGAGGAACGGAGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.745509988108624													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit256	chr12	7036994	7037044	6927831	6927881	16705	hg38					enhancer	NANOGe+8-18				CGCGGGGCTGCGGACGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60862765284513964													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit257	chr12	7036673	7036723	6927510	6927560	16706	hg38					enhancer	NANOGe+8-19				GGCTAGGTAGGAGGGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.666403498950968													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit258	chr12	7036951	7037001	6927788	6927838	16707	hg38					enhancer	NANOGe+8-2				ACAGGAAAGCGGACGGCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71559396341349024													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit259	chr12	7036852	7036902	6927689	6927739	16708	hg38					enhancer	NANOGe+8-20				GGGCCAGGAGGGAGACGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50677288684269672													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit260	chr12	7036752	7036802	6927589	6927639	16709	hg38					enhancer	NANOGe+8-21				CGCCCCGGCCCCCTCGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45511718827628461													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit261	chr12	7036839	7036889	6927676	6927726	16710	hg38					enhancer	NANOGe+8-22				GACGCGAGGGAGGGAGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50333910323420072													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit262	chr12	7036922	7036972	6927759	6927809	16711	hg38					enhancer	NANOGe+8-23				TTCTCCCATCCCCCTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92319489272540389													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit263	chr12	7036654	7036704	6927491	6927541	16712	hg38					enhancer	NANOGe+8-24				TGGGTGGTGAGGGCAGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86955504262330974													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit264	chr12	7036889	7036939	6927726	6927776	16713	hg38					enhancer	NANOGe+8-25				GGGAGAAGGAGGGAGCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7342668883712884													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit265	chr12	7037068	7037118	6927905	6927955	16714	hg38					enhancer	NANOGe+8-26				AGGGGCTAGGAGGGGGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	11.049857112719851													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit266	chr12	7036799	7036849	6927636	6927686	16715	hg38					enhancer	NANOGe+8-27				GAGAGGGGGAGCCGGAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70115322998131568													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit267	chr12	7036863	7036913	6927700	6927750	16716	hg38					enhancer	NANOGe+8-28				GGAGGAGAGAGGGGCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6191474892579516													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit268	chr12	7036909	7036959	6927746	6927796	16717	hg38					enhancer	NANOGe+8-29				GATGGGAGAAGGGAGGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74868412973860754													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit269	chr12	7036721	7036771	6927558	6927608	16718	hg38					enhancer	NANOGe+8-3				GCTAGCCGTGGCGGAATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1682541875605357													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit270	chr12	7036963	7037013	6927800	6927850	16719	hg38					enhancer	NANOGe+8-4				CGCTTTCCTGTGCGAGTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12816568326593891													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit271	chr12	7036826	7036876	6927663	6927713	16720	hg38					enhancer	NANOGe+8-5				GAGCGCGAGGCAAGCCGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54376104959240368													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit272	chr12	7036687	7036737	6927524	6927574	16721	hg38					enhancer	NANOGe+8-6				TACCTAGCCCTCTCCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43509488431696858													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit273	chr12	7037088	7037138	6927925	6927975	16722	hg38					enhancer	NANOGe+8-7				GGGAGCCGACTGCCGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34160706598005153													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit274	chr12	7037054	7037104	6927891	6927941	16723	hg38					enhancer	NANOGe+8-8				CTAGCCCCTCCCCGAAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26810661865108709													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit275	chr12	7036769	7036819	6927606	6927656	16724	hg38					enhancer	NANOGe+8-9				GCGCGAGTTGGCCGAGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42094427243228127													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034112	7034162	6924949	6924999	16725	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-1				CAATCCAACCCCGATACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1142604483958904					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit276	chr12	7034342	7034392	6925179	6925229	16726	hg38					enhancer	NANOGe+9-10				ATAAGCCTGGCCCTCAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.006588507117956206													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034316	7034366	6925153	6925203	16727	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-11				AGAGAGATGTCCCCTGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24738969036561159					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit277	chr12	7034353	7034403	6925190	6925240	16728	hg38					enhancer	NANOGe+9-12				TCCCATTCCTCCCCTACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49631954199250428													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit278	chr12	7033952	7034002	6924789	6924839	16729	hg38					enhancer	NANOGe+9-13				TGTGCCTCTCAGTTTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12599204082037671													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034068	7034118	6924905	6924955	16730	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-14				GAGAAGGCGACCTGGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45483507195640682					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034036	7034086	6924873	6924923	16731	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-15				AAGGACAGAGGCTAGGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08074341558963663					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit279	chr12	7034368	7034418	6925205	6925255	16732	hg38					enhancer	NANOGe+9-16				GAATGGGAGAGGGTAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60993769414293													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit280	chr12	7033938	7033988	6924775	6924825	16733	hg38					enhancer	NANOGe+9-17				AGAGGCACAGAGGAAAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60276800818364462													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034216	7034266	6925053	6925103	16734	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-18				GTGGGGGGCTGAGCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070467004871450273					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034161	7034211	6924998	6925048	16735	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-19				GAAAGTGGAGAGAAGGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.02336574645526					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034079	7034129	6924916	6924966	16736	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-2				GGTCGCCTTCTCTGACAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.195099667808771					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034239	7034289	6925076	6925126	16737	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-20				AGCTGGGGTGAGGGATGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16601046506471831					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034055	7034105	6924892	6924942	16738	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-21				GGTGAGGAGGGATGAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061465276329033827					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit281	chr12	7033985	7034035	6924822	6924872	16739	hg38					enhancer	NANOGe+9-3				GGGAGTTACTAAGGTAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79713957561777693													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034025	7034075	6924862	6924912	16740	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-4				CTAGGAACTAGGCTCAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.002698511219165119					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-35412	chr12	7034184	7034234	6925021	6925071	16741	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-5				GTCTCCAGGCAACGGCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1053374736683539					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit282	chr12	7034006	7034056	6924843	6924893	16742	hg38					enhancer	NANOGe+9-6				TAGGATAGTCCTGGTCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67494861185283028													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034135	7034185	6924972	6925022	16743	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-7				GGTTACAGCTAGCTCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19841030429907361					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit283	chr12	7034327	7034377	6925164	6925214	16744	hg38					enhancer	NANOGe+9-8				AGGCTTATAGTCCAGCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.065221689534742722													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-35412	chr12	7034198	7034248	6925035	6925085	16745	hg38	N/A	N/A	fant40819	N/A	enhancer	NANOGe+9-9				CCTGGAGACCAATGGGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029753517348322819					ATN1	chr12	6924462	6942321	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	722
enhrx-lit284	chr6	31126494	31126544	31158717	31158767	16746	hg38					enhancer	OCT4e-1-1				GCGCGGGTAGATCCGAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8707102532223806													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit285	chr6	31126090	31126140	31158313	31158363	16747	hg38					enhancer	OCT4e-1-10				GGCGCAGTGGCGTCTAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12282105190195219													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit286	chr6	31126310	31126360	31158533	31158583	16748	hg38					enhancer	OCT4e-1-11				ACCCCTCCTTCGGAATTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45382663749508062													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit287	chr6	31126231	31126281	31158454	31158504	16749	hg38					enhancer	OCT4e-1-12				TGTGTTCTCTTCCGCGCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039412991713156827													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit288	chr6	31126023	31126073	31158246	31158296	16750	hg38					enhancer	OCT4e-1-13				TTAGGGCGCCCGCCTTGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90790794611900827													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit289	chr6	31125943	31125993	31158166	31158216	16751	hg38					enhancer	OCT4e-1-14				CAGTAGGGGGCTCTCGCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31536812721483259													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit290	chr6	31126126	31126176	31158349	31158399	16752	hg38					enhancer	OCT4e-1-15				GTCGGAGCATCTCCGCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58279677839491684													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit291	chr6	31125956	31126006	31158179	31158229	16753	hg38					enhancer	OCT4e-1-16				TGTGGCCAAAGCGCAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50913569675426806													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit292	chr6	31125863	31125913	31158086	31158136	16754	hg38					enhancer	OCT4e-1-17				GGAGGGTTCAAGGGGTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0478382134425639													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit293	chr6	31126370	31126420	31158593	31158643	16755	hg38					enhancer	OCT4e-1-18				GTTTGACAGCCAAGAAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34664068497544231													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit294	chr6	31126431	31126481	31158654	31158704	16756	hg38					enhancer	OCT4e-1-19				GGTCCCGGGATCCGCCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1209824141611358													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit295	chr6	31126157	31126207	31158380	31158430	16757	hg38					enhancer	OCT4e-1-2				TTTCCCGGGTTGCCGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99492870578337078													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit296	chr6	31126399	31126449	31158622	31158672	16758	hg38					enhancer	OCT4e-1-20				AGCAACGTCGGCTCCTGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.681012425271249													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit297	chr6	31126011	31126061	31158234	31158284	16759	hg38					enhancer	OCT4e-1-21				CCCCTGACCGCGCCTGCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3373348509630707													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit298	chr6	31126332	31126382	31158555	31158605	16760	hg38					enhancer	OCT4e-1-22				TAGGCGCTGCCCGCGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51607541427160852													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit299	chr6	31126048	31126098	31158271	31158321	16761	hg38					enhancer	OCT4e-1-23				TCCTATTTCACTCTGTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4604842418089809													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit300	chr6	31126077	31126127	31158300	31158350	16762	hg38					enhancer	OCT4e-1-24				AAAGGTGTACGCAGGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73236919402578049													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit301	chr6	31126387	31126437	31158610	31158660	16763	hg38					enhancer	OCT4e-1-25				TCAAACAGATGCAGCAACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3861679777437223													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit302	chr6	31125848	31125898	31158071	31158121	16764	hg38					enhancer	OCT4e-1-26				TCCAAAGGGGAAGGGGGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66296883090289427													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit303	chr6	31126201	31126251	31158424	31158474	16765	hg38					enhancer	OCT4e-1-27				AGTGGAAGGCGGGAGATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78430886156567292													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit304	chr6	31125903	31125953	31158126	31158176	16766	hg38					enhancer	OCT4e-1-28				GAGTCGGTTGGGGGCGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42659373936457279													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit305	chr6	31126247	31126297	31158470	31158520	16767	hg38					enhancer	OCT4e-1-29				GAACACATGAGCTGGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0746430361713185													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit306	chr6	31126115	31126165	31158338	31158388	16768	hg38					enhancer	OCT4e-1-3				AGATGCTCCGACGCATTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22719256524125869													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit307	chr6	31126172	31126222	31158395	31158445	16769	hg38					enhancer	OCT4e-1-30				GATTAGTTCACAAGTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14772340509046111													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit308	chr6	31126412	31126462	31158635	31158685	16770	hg38					enhancer	OCT4e-1-31				GACCCCTTGGGCTCCTCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16994267139695021													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit309	chr6	31126461	31126511	31158684	31158734	16771	hg38					enhancer	OCT4e-1-32				TGCTTGAAGAGGAGGCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66557832197284417													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit310	chr6	31126445	31126495	31158668	31158718	16772	hg38					enhancer	OCT4e-1-33				TCAAGCAGTGCCAGCCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5014095897379548													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit311	chr6	31126144	31126194	31158367	31158417	16773	hg38					enhancer	OCT4e-1-34				CGCAGTGAGGAGGAGCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4366388767871481													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit312	chr6	31125981	31126031	31158204	31158254	16774	hg38					enhancer	OCT4e-1-35				GGGGCCGGGAGCGAGGCGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55164974669086009													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit313	chr6	31126274	31126324	31158497	31158547	16775	hg38					enhancer	OCT4e-1-36				GGCACGGGGGCGGGCTCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00967384143608219													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit314	chr6	31126000	31126050	31158223	31158273	16776	hg38					enhancer	OCT4e-1-37				CGCGGTCAGGGGCAGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1091734718310791													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit315	chr6	31126347	31126397	31158570	31158620	16777	hg38					enhancer	OCT4e-1-38				CGCAGAGGCCGCGCCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82642146028649976													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit316	chr6	31126183	31126233	31158406	31158456	16778	hg38					enhancer	OCT4e-1-39				TGTGAACTAATCAGAAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.086010532132817855													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit317	chr6	31125914	31125964	31158137	31158187	16779	hg38					enhancer	OCT4e-1-4				ACGTTCGGGAAGAGTCGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97354311449137965													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit318	chr6	31125885	31125935	31158108	31158158	16780	hg38					enhancer	OCT4e-1-40				AAGGGGCTGAGCGGGGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020484421901080709													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit319	chr6	31125834	31125884	31158057	31158107	16781	hg38					enhancer	OCT4e-1-41				GGGTACAGGGGCCAGGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69458544837780811													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit320	chr6	31126059	31126109	31158282	31158332	16782	hg38					enhancer	OCT4e-1-42				TCTGTTGGGAGGAGGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.164897461307457													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit321	chr6	31126286	31126336	31158509	31158559	16783	hg38					enhancer	OCT4e-1-5				GGCTCGCTCGGCGCGAAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42098015536203781													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit322	chr6	31125929	31125979	31158152	31158202	16784	hg38					enhancer	OCT4e-1-6				CGCGGTTGGTAAGGGACGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13549077071438631													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit323	chr6	31126220	31126270	31158443	31158493	16785	hg38					enhancer	OCT4e-1-7				TGGGGCGCTGTCCAATGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44371758350238971													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit324	chr6	31126477	31126527	31158700	31158750	16786	hg38					enhancer	OCT4e-1-8				TACTCGGAGACTGCGCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42791908429804171													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit325	chr6	31126258	31126308	31158481	31158531	16787	hg38					enhancer	OCT4e-1-9				CTGGCCAATCGGGAACGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45682103146370068													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139714	chr6	29727566	29727616	29759789	29759839	16788	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-1				CATATACATCCCTTATGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.064972313294317					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727219	29727269	29759442	29759492	16789	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-10				TGGAGGTTAGGTTCTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094170226903727727					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727101	29727151	29759324	29759374	16790	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-11				AGTGACAAGGGAAATCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29553210211207248					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727432	29727482	29759655	29759705	16791	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-12				GTTGTGTGAGGCCTCCGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16811695869490359					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727113	29727163	29759336	29759386	16792	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-13				TCAGGGTGAGTGAGTGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71658849158332527					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727324	29727374	29759547	29759597	16793	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-14				GCTTTGTTGAGCACAGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34122141389369842					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727640	29727690	29759863	29759913	16794	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-15				GCACACAGGATCCTGGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08102326850312					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727202	29727252	29759425	29759475	16795	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-16				CAGCCATTAATAAAACATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1028816262780147					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727055	29727105	29759278	29759328	16796	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-17				CTGGACCATCATTTCTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0174026957809952					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727302	29727352	29759525	29759575	16797	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-18				GCCACACACCACTCAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056377989491032891					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727618	29727668	29759841	29759891	16798	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-19				GGACAGAGCATGGCCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1455831318001839					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727670	29727720	29759893	29759943	16799	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-2				TTGTCGTCCCCTAAAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34239777506614838					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727242	29727292	29759465	29759515	16800	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-20				ATTCTGAGGATCTGCTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19744720555763559					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727479	29727529	29759702	29759752	16801	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-21				GTATCTGCCCTTGACCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9202265875576936					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727168	29727218	29759391	29759441	16802	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-22				ATATCATTTCTTTGAAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093743028376710988					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727364	29727414	29759587	29759637	16803	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-23				AGAGATCCAGACAAATAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0710632375707649					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727348	29727398	29759571	29759621	16804	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-24				AAACAGGAAATGACCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.544616930699613					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727629	29727679	29759852	29759902	16805	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-25				CATGCTCTGTCCCTGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16348402996487729					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727582	29727632	29759805	29759855	16806	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-26				GTATATGAGCATTATTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37320910525557222					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727697	29727747	29759920	29759970	16807	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-27				CTGAGAAGCCCCATGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.196185636992905					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727444	29727494	29759667	29759717	16808	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-28				GCTCAGCCTGGAGTTGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32213609323042991					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727414	29727464	29759637	29759687	16809	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-29				TTAGGGGTGGGTGCTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15740632872071511					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727605	29727655	29759828	29759878	16810	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-3				AGAGCCGCTATGTCCCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22506198536087471					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727654	29727704	29759877	29759927	16811	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-30				ACGACAACAACAAAGCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048285340129223447					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727066	29727116	29759289	29759339	16812	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-31				TTTCTTTTCTGGGAATGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95313741891521142					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727284	29727334	29759507	29759557	16813	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-32				AGAAGGGCGGGTGGAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.210785933175843					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727739	29727789	29759962	29760012	16814	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-33				ACAGGAAAGAAGGCAGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7618197298914069					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727272	29727322	29759495	29759545	16815	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-34				GCAGGTGGGGAGAGAAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.212735633886997					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727258	29727308	29759481	29759531	16816	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-35				GTGCTGGGGCAGGGGCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075928080700802161					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727519	29727569	29759742	29759792	16817	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-4				GCCCTCGCCTCCACTTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30502070259131953					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727388	29727438	29759611	29759661	16818	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-5				CTTGCATTGTGATTGGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.011701214344993931					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727401	29727451	29759624	29759674	16819	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-6				TGGTGCCTGGTCTTTAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61596892535137548					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727131	29727181	29759354	29759404	16820	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-7				ATAGAGTAAGAAGTCTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.6064633300101541					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727465	29727515	29759688	29759738	16821	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-8				GCCTTTCTTCAAGTCCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027290608479944242					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139714	chr6	29727335	29727385	29759558	29759608	16822	hg38	N/A	enh59606	N/A	Enhatls149353	enhancer	OCT4e-10-9				GCTCAACAAAGCTCCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1197892034171147					HLA-F	chr6	29722774	29738528	17626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1302
enhrx-139695	chr6	29629754	29629804	29661977	29662027	16823	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-1				GGGACGCTTTGTCTAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.213183653311655					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629848	29629898	29662071	29662121	16824	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-10				ACTCTTCAGAGAAAGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31962027417181582					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629686	29629736	29661909	29661959	16825	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-11				GGGAACAGGAGGTTGGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85830771088303159					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629560	29629610	29661783	29661833	16826	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-12				TCCAGTCTGGGCAAGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079540322492182416					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629480	29629530	29661703	29661753	16827	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-13				TCCTGCCTCAGCCTCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55625304397816					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629547	29629597	29661770	29661820	16828	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-14				CGTGCCATTACACTCCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41864407288335881					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629501	29629551	29661724	29661774	16829	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-15				GAGAATCGCTTGAACCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4649914261412049					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629598	29629648	29661821	29661871	16830	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-16				AAAAAAAAAAAAAAAAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629515	29629565	29661738	29661788	16831	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-17				CACTGCAACCTCCGCCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75006434066072736					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629710	29629760	29661933	29661983	16832	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-2				TCTTAGGCATGCAGACGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.334252661894175					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629638	29629688	29661861	29661911	16833	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-3				AGCTAAAGACTTTGCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0649942162442224					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629817	29629867	29662040	29662090	16834	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-4				ATGGTATTATTGCAAGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53240943362567261					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629655	29629705	29661878	29661928	16835	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-5				CAGGGGAGAAAGTTCTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70753050911279813					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629779	29629829	29662002	29662052	16836	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-6				CTAAATTTGTCTCAACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31317240104082211					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629798	29629848	29662021	29662071	16837	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-7				TTAGGAATGAGATGAAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28019928431663632					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629734	29629784	29661957	29662007	16838	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-8				ACTGTTTTACAAGTAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8567247433822991					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-139695	chr6	29629697	29629747	29661920	29661970	16839	hg38	N/A	enh72219	N/A	Enhatls149333	enhancer	OCT4e-11-9				GACGAAGAGGTGGGAACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46312277901405058					MOG	chr6	29657002	29672372	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1283
enhrx-lit326	chr6	31111162	31111212	31143385	31143435	16840	hg38					enhancer	OCT4e-2-1				TCTGCGCTGAATCTGGCGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63679477685130959													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit327	chr6	31110993	31111043	31143216	31143266	16841	hg38					enhancer	OCT4e-2-10				GCAGACACTAGGGCCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.052740740223284													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit328	chr6	31111027	31111077	31143250	31143300	16842	hg38					enhancer	OCT4e-2-11				ACCTCATGCTGGTAGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.405453250508328													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit329	chr6	31111254	31111304	31143477	31143527	16843	hg38					enhancer	OCT4e-2-12				TGAAGACAGGAACAAACGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057628224782188507													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit330	chr6	31111113	31111163	31143336	31143386	16844	hg38					enhancer	OCT4e-2-13				GGAACTCAGGCGTCTGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.011629939853731411													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit331	chr6	31111135	31111185	31143358	31143408	16845	hg38					enhancer	OCT4e-2-14				CTGGCTCCGCTCCTTTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17253608654081079													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit332	chr6	31110963	31111013	31143186	31143236	16846	hg38					enhancer	OCT4e-2-15				TCTTTCCACACCTCTAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0042929833674959237													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit333	chr6	31111086	31111136	31143309	31143359	16847	hg38					enhancer	OCT4e-2-16				GTCGCTGCCCCTCCTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65416067412512224													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit334	chr6	31111101	31111151	31143324	31143374	16848	hg38					enhancer	OCT4e-2-17				TCTGCAGGAGGAGGCCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016860941147540179													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit335	chr6	31111234	31111284	31143457	31143507	16849	hg38					enhancer	OCT4e-2-18				TCATGGTGCCTGGCTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.153500250407704													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit336	chr6	31111218	31111268	31143441	31143491	16850	hg38					enhancer	OCT4e-2-19				GCAGGTGTGAGTCAGGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89194887162774228													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit337	chr6	31110932	31110982	31143155	31143205	16851	hg38					enhancer	OCT4e-2-2				AGGGAGGCTCTATCCGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.210476827020218													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit338	chr6	31110975	31111025	31143198	31143248	16852	hg38					enhancer	OCT4e-2-20				TCTAGCCCAGGAACCAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3557858328313529													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit339	chr6	31111004	31111054	31143227	31143277	16853	hg38					enhancer	OCT4e-2-21				AGGGCAGACAGGCAGACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.685493809020254													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit340	chr6	31110903	31110953	31143126	31143176	16854	hg38					enhancer	OCT4e-2-22				CAAGGTGGCCTGGGAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.473108732129057													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit341	chr6	31110951	31111001	31143174	31143224	16855	hg38					enhancer	OCT4e-2-23				GTGTGGAAAGAGGATGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0697820720635399													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit342	chr6	31111015	31111065	31143238	31143288	16856	hg38					enhancer	OCT4e-2-24				TAGGAGACAGGAGGGCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77907274335955934													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit343	chr6	31111200	31111250	31143423	31143473	16857	hg38					enhancer	OCT4e-2-25				GGCCAAGGCACAGAGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5876995716192681													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit344	chr6	31111038	31111088	31143261	31143311	16858	hg38					enhancer	OCT4e-2-3				GAGGGATAAGAACCTCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.030051634273889													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit345	chr6	31111068	31111118	31143291	31143341	16859	hg38					enhancer	OCT4e-2-4				GCGACTGGCCCGGCGCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.6477316159423858													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit346	chr6	31111146	31111196	31143369	31143419	16860	hg38					enhancer	OCT4e-2-5				GCGCAGAGCCGCCCAGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41898889131318079													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit347	chr6	31111179	31111229	31143402	31143452	16861	hg38					enhancer	OCT4e-2-6				GTAAGGAGACCACTACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.042598662225301627													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit348	chr6	31110888	31110938	31143111	31143161	16862	hg38					enhancer	OCT4e-2-7				GAGACCTTCCTGCTGCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.028102369224571631													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit349	chr6	31110919	31110969	31143142	31143192	16863	hg38					enhancer	OCT4e-2-8				GGAGAGGGTTAAACCTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19817606332972429													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit350	chr6	31111057	31111107	31143280	31143330	16864	hg38					enhancer	OCT4e-2-9				GGCGCTTGCAGGAGCTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096028335421323108													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139915	chr6	31038609	31038659	31070832	31070882	16865	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-1				CGAGCTAATCCTGTCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39846853821483719					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038776	31038826	31070999	31071049	16866	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-10				ACAGGGGATTCCTCCTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36514514707823548					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038804	31038854	31071027	31071077	16867	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-11				TTGCATTCTCTGGGACTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033927634265278658					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038726	31038776	31070949	31070999	16868	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-12				ATGCCATACAGTTGCAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30570715871886323					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038583	31038633	31070806	31070856	16869	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-13				TGCTAGGAAGCGAGCTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1741467067749603					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038480	31038530	31070703	31070753	16870	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-14				TTCCTACACTCCCACTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0092184953510856659					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038496	31038546	31070719	31070769	16871	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-15				GTAGGAAAGGAGGAGGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2539292388506007					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038653	31038703	31070876	31070926	16872	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-16				ACTTCAGCTTCTCTCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063763377492259868					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038630	31038680	31070853	31070903	16873	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-2				GGCCACCTACAGGCATCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2457313079934039					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038562	31038612	31070785	31070835	16874	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-3				CATGCCTCACACTAGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0407209608544824					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038763	31038813	31070986	31071036	16875	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-4				CTCGGAAGAAGCACCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.210526314703612					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038521	31038571	31070744	31070794	16876	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-5				GCCCTGAAAACCTGGGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0345342649770472					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038695	31038745	31070918	31070968	16877	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-6				GCTGTGGGAGGAATAAATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24749676562615069					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038792	31038842	31071015	31071065	16878	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-7				GGACTGGTAGGGGCTTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8702655306140884					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038679	31038729	31070902	31070952	16879	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-8				TACTGCATTCCTATGAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19635010803841441					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139915	chr6	31038737	31038787	31070960	31071010	16880	hg38	N/A	enh38944	N/A	Enhatls149570	enhancer	OCT4e-3-9				ACTGTATGGCATTAGGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.066896450198817					HCG22	chr6	31054329	31059876	8521				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1503
enhrx-139906	chr6	30910479	30910529	30942702	30942752	16881	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-1				CAGTGGACAATCCGCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42197356198728392					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910479	30910529	30942702	30942752	16882	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-1				CAGTGGACAATCCGCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42197356198728392					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910664	30910714	30942887	30942937	16883	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-10				ATAGGCGTGGCTGGGCGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0499109118527882					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910664	30910714	30942887	30942937	16884	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-10				ATAGGCGTGGCTGGGCGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0499109118527882					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910392	30910442	30942615	30942665	16885	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-11				TCTCCCCTACCTTGAGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0851258240202199					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910392	30910442	30942615	30942665	16886	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-11				TCTCCCCTACCTTGAGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0851258240202199					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910340	30910390	30942563	30942613	16887	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-12				GCACTGCTGAGACCTTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1067982989780189					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910340	30910390	30942563	30942613	16888	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-12				GCACTGCTGAGACCTTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1067982989780189					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910515	30910565	30942738	30942788	16889	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-13				TCCTTAAGCTGCAAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50622682144101461					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910515	30910565	30942738	30942788	16890	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-13				TCCTTAAGCTGCAAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50622682144101461					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910515	30910565	30942738	30942788	16891	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-13				TCCTTAAGCTGCAAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50622682144101461					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910515	30910565	30942738	30942788	16892	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-13				TCCTTAAGCTGCAAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50622682144101461					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910365	30910415	30942588	30942638	16893	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-14				CATCAAGTCAGGGCACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.408346158097964					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910365	30910415	30942588	30942638	16894	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-14				CATCAAGTCAGGGCACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.408346158097964					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910545	30910595	30942768	30942818	16895	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-15				GATTCCCTTCCGCCCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0180437395074854					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910545	30910595	30942768	30942818	16896	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-15				GATTCCCTTCCGCCCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0180437395074854					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910530	30910580	30942753	30942803	16897	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-16				CTTAAGGAAGAGGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54485236829377059					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910530	30910580	30942753	30942803	16898	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-16				CTTAAGGAAGAGGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54485236829377059					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910530	30910580	30942753	30942803	16899	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-16				CTTAAGGAAGAGGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54485236829377059					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910530	30910580	30942753	30942803	16900	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-16				CTTAAGGAAGAGGAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54485236829377059					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910759	30910809	30942982	30943032	16901	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-17				TTACAGGTGGGGAGGGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97462812286945288					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910759	30910809	30942982	30943032	16902	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-17				TTACAGGTGGGGAGGGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97462812286945288					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910435	30910485	30942658	30942708	16903	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-18				AGATGGGGCCGGGAGGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38821354615820369					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910435	30910485	30942658	30942708	16904	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-18				AGATGGGGCCGGGAGGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38821354615820369					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910724	30910774	30942947	30942997	16905	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-19				TGTCTTCAAAATCTGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.190322644403366					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910724	30910774	30942947	30942997	16906	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-19				TGTCTTCAAAATCTGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.190322644403366					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910724	30910774	30942947	30942997	16907	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-19				TGTCTTCAAAATCTGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.190322644403366					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910724	30910774	30942947	30942997	16908	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-19				TGTCTTCAAAATCTGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.190322644403366					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910572	30910622	30942795	30942845	16909	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-2				AATCTCAGAGCGACTGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47298432925236461					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910572	30910622	30942795	30942845	16910	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-2				AATCTCAGAGCGACTGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47298432925236461					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910468	30910518	30942691	30942741	16911	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-20				TCCTTCCCCTTCCTCTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5474372154610897					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910468	30910518	30942691	30942741	16912	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-20				TCCTTCCCCTTCCTCTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5474372154610897					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910446	30910496	30942669	30942719	16913	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-21				AAAGGCGGGAGAGATGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95510258185040953					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910446	30910496	30942669	30942719	16914	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-21				AAAGGCGGGAGAGATGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95510258185040953					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910770	30910820	30942993	30943043	16915	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-22				GAGGGCTTGAGGCTGGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59104477037693348					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910770	30910820	30942993	30943043	16916	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-22				GAGGGCTTGAGGCTGGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59104477037693348					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910677	30910727	30942900	30942950	16917	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-23				GGCGGCATGGAGGGAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11087104053126511					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910677	30910727	30942900	30942950	16918	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-23				GGCGGCATGGAGGGAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11087104053126511					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910677	30910727	30942900	30942950	16919	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-23				GGCGGCATGGAGGGAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11087104053126511					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910677	30910727	30942900	30942950	16920	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-23				GGCGGCATGGAGGGAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11087104053126511					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910496	30910546	30942719	30942769	16921	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-24				AAGGAGGAGAGAGCAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035927551659320628					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910496	30910546	30942719	30942769	16922	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-24				AAGGAGGAGAGAGCAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035927551659320628					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910496	30910546	30942719	30942769	16923	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-24				AAGGAGGAGAGAGCAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035927551659320628					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910496	30910546	30942719	30942769	16924	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-24				AAGGAGGAGAGAGCAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035927551659320628					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910695	30910745	30942918	30942968	16925	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-25				GTGGGGAGGACAAGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44908014875022839					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910695	30910745	30942918	30942968	16926	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-25				GTGGGGAGGACAAGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44908014875022839					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910695	30910745	30942918	30942968	16927	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-25				GTGGGGAGGACAAGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44908014875022839					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910695	30910745	30942918	30942968	16928	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-25				GTGGGGAGGACAAGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44908014875022839					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910619	30910669	30942842	30942892	16929	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-3				CATGGCCCCATCGGAATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36676190428717881					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910619	30910669	30942842	30942892	16930	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-3				CATGGCCCCATCGGAATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36676190428717881					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910651	30910701	30942874	30942924	16931	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-4				TCTCGGAGAGGAGATAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.130997395447703					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910651	30910701	30942874	30942924	16932	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-4				TCTCGGAGAGGAGATAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.130997395447703					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910786	30910836	30943009	30943059	16933	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-5				GCTCGGGTTGTGATGAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44732057167155093					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910786	30910836	30943009	30943059	16934	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-5				GCTCGGGTTGTGATGAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44732057167155093					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910743	30910793	30942966	30943016	16935	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-6				GACAAGAGTGAGTGGGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2294043461530805					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910743	30910793	30942966	30943016	16936	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-6				GACAAGAGTGAGTGGGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2294043461530805					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910639	30910689	30942862	30942912	16937	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-7				ATGTGGGCGTGGTCTCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37142353018838542					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910639	30910689	30942862	30942912	16938	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-7				ATGTGGGCGTGGTCTCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37142353018838542					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910376	30910426	30942599	30942649	16939	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-8				GGGGAGACAGACATCAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32666131258456232					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910376	30910426	30942599	30942649	16940	hg38	N/A	N/A	N/A	Enhatls149558	enhancer	OCT4e-4-8				GGGGAGACAGACATCAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32666131258456232					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910585	30910635	30942808	30942858	16941	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-9				CTCTGAGATTTGCTTCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48154522649307269					MUCL3	chr6	30934522	30954221	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-139906	chr6	30910585	30910635	30942808	30942858	16942	hg38	N/A	N/A	fant22190	Enhatls149558	enhancer	OCT4e-4-9				CTCTGAGATTTGCTTCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48154522649307269					SFTA2	chr6	30931352	30955636	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1494
enhrx-lit351	chr6	30854076	30854126	30886299	30886349	16943	hg38					enhancer	OCT4e-5-1				CCCGCTGTTCCCGAGAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71827124628289718													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit352	chr6	30854541	30854591	30886764	30886814	16944	hg38					enhancer	OCT4e-5-10				AGGTGGCAGTCGAGTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47377712948969758													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit353	chr6	30854397	30854447	30886620	30886670	16945	hg38					enhancer	OCT4e-5-11				GCTGAGTTGCCTTGGAGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.080092733067471													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit354	chr6	30854291	30854341	30886514	30886564	16946	hg38					enhancer	OCT4e-5-12				GCTGCTCCCACAATGCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13359549350669639													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit355	chr6	30854019	30854069	30886242	30886292	16947	hg38					enhancer	OCT4e-5-13				TGTGGCTCTGATGACTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66100563104746923													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit356	chr6	30854193	30854243	30886416	30886466	16948	hg38					enhancer	OCT4e-5-14				ACTCAGAGGCTAGAACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22202387710618149													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit357	chr6	30854462	30854512	30886685	30886735	16949	hg38					enhancer	OCT4e-5-15				AACTGGGGGGACTGGATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29358508935082461													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit358	chr6	30853983	30854033	30886206	30886256	16950	hg38					enhancer	OCT4e-5-16				AGCCCGGGGCAGAGATACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34493831079703557													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit359	chr6	30853916	30853966	30886139	30886189	16951	hg38					enhancer	OCT4e-5-17				ATGCAAGAGGTAAATAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2185568266186981													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit360	chr6	30854033	30854083	30886256	30886306	16952	hg38					enhancer	OCT4e-5-18				CTCATCTGGGATAGGCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26189867216416979													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit361	chr6	30854351	30854401	30886574	30886624	16953	hg38					enhancer	OCT4e-5-19				AGGTCACCCCAGGAGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64172103654772272													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit362	chr6	30854158	30854208	30886381	30886431	16954	hg38					enhancer	OCT4e-5-2				TCCCTTAGGGTCCAGCGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2558228804211336													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit363	chr6	30854097	30854147	30886320	30886370	16955	hg38					enhancer	OCT4e-5-20				GGGGTTGGAGAGCGGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32734803551990149													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit364	chr6	30854276	30854326	30886499	30886549	16956	hg38					enhancer	OCT4e-5-21				CACTAGGGCAGGAATGTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1692277492577966													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit365	chr6	30854438	30854488	30886661	30886711	16957	hg38					enhancer	OCT4e-5-22				AGGCAGCCACCTTCTGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01282672877343643													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit366	chr6	30853903	30853953	30886126	30886176	16958	hg38					enhancer	OCT4e-5-23				ATAGAGCAGGCTCAGAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22141498088615419													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit367	chr6	30854493	30854543	30886716	30886766	16959	hg38					enhancer	OCT4e-5-24				AAGGCAGAGCAGGGATAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1501326451615031													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit368	chr6	30853997	30854047	30886220	30886270	16960	hg38					enhancer	OCT4e-5-25				ACAGAGCCGAGAGGAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70263691750795043													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit369	chr6	30853961	30854011	30886184	30886234	16961	hg38					enhancer	OCT4e-5-26				GCAGGCAGAGGATACGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49013073985055028													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit370	chr6	30854418	30854468	30886641	30886691	16962	hg38					enhancer	OCT4e-5-27				GCCTTTCCTCAGTCCCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75201389374697969													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit371	chr6	30854136	30854186	30886359	30886409	16963	hg38					enhancer	OCT4e-5-28				GAGCAGGCTGCCAGAGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1060983755659262													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit372	chr6	30854147	30854197	30886370	30886420	16964	hg38					enhancer	OCT4e-5-29				GGCAGCCTGCTCCCCGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.005340888447543													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit373	chr6	30854181	30854231	30886404	30886454	16965	hg38					enhancer	OCT4e-5-3				GAACCAGAAGGCATCACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19339513782264589													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit374	chr6	30854243	30854293	30886466	30886516	16966	hg38					enhancer	OCT4e-5-30				AGCTGCTGCTTCAGAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1119738619300522													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit375	chr6	30854474	30854524	30886697	30886747	16967	hg38					enhancer	OCT4e-5-31				TGGATGTCTGGGTCTCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.825006453078249													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit376	chr6	30854313	30854363	30886536	30886586	16968	hg38					enhancer	OCT4e-5-32				CTGGAGGAGGACAAAGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2215633776692591													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit377	chr6	30854449	30854499	30886672	30886722	16969	hg38					enhancer	OCT4e-5-33				TTCTGGAAGTGGGAACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20853233799947449													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit378	chr6	30854207	30854257	30886430	30886480	16970	hg38					enhancer	OCT4e-5-34				GAGTTGTGGGGGGCACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.601172952209607													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit379	chr6	30854379	30854429	30886602	30886652	16971	hg38					enhancer	OCT4e-5-4				CGAGGGCGGGTCTAAAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15677352792778709													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit380	chr6	30854218	30854268	30886441	30886491	16972	hg38					enhancer	OCT4e-5-5				GGGGGACGACTGAGTTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10094278387916041													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit381	chr6	30854044	30854094	30886267	30886317	16973	hg38					enhancer	OCT4e-5-6				TAGGCATGAAGGTTACTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28440002089729682													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit382	chr6	30854526	30854576	30886749	30886799	16974	hg38					enhancer	OCT4e-5-7				TGCCACCTCTTATCAGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.059942368988359362													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit383	chr6	30853929	30853979	30886152	30886202	16975	hg38					enhancer	OCT4e-5-8				AGCGAGAGCCACAATGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43113481587654													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit384	chr6	30854119	30854169	30886342	30886392	16976	hg38					enhancer	OCT4e-5-9				GAATTCCAAGCCAGTCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36547806744364869													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139865	chr6	30848800	30848850	30881023	30881073	16977	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-1				TGGCTTTGTCCGAGCGTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19003704606950239					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848978	30849028	30881201	30881251	16978	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-10				GGGACCAGGCGGTCCCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1414159757557174					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848436	30848486	30880659	30880709	16979	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-11				AGATTAGAATTGACTGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.013383274551947631					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848739	30848789	30880962	30881012	16980	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-12				GGCTGGCTTCAATGTGACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48393808748870643					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848510	30848560	30880733	30880783	16981	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-13				CTAGATTCTCCCCCTCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21677873370585929					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848701	30848751	30880924	30880974	16982	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-14				GGGCCTAGAGGCTCGGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.321033655271696					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848467	30848517	30880690	30880740	16983	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-15				GAAGCAGGGGCTGATTTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41570294696108168					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848354	30848404	30880577	30880627	16984	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-16				TGGGATTCTGGTTCTCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6199795124225983					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848342	30848392	30880565	30880615	16985	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-17				CAACTAAGAAACTGGGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10542886334904709					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848953	30849003	30881176	30881226	16986	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-18				GAGCTGGGCCCTCCCCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1080377002963414					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848753	30848803	30880976	30881026	16987	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-19				AAGCCAGCCGCAGCTGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38699263678471979					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848690	30848740	30880913	30880963	16988	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-2				GCCTCTAGGCCCCCGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28493204451398119					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848626	30848676	30880849	30880899	16989	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-20				GAACTGTGAAACAGAACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29192647200998939					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848911	30848961	30881134	30881184	16990	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-21				GGGGAAGCCAGAGATGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22655113737366389					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848858	30848908	30881081	30881131	16991	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-22				GTCCCAGTCACCCCAGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36652531356006268					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848582	30848632	30880805	30880855	16992	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-23				TCCCTTCATCTCCTTTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57528996369620466					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848521	30848571	30880744	30880794	16993	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-24				GGGAGCTCAGGCCCTCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.643927963837295					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848492	30848542	30880715	30880765	16994	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-25				TCTAGGAGAGGCGGAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0448186563474483					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848679	30848729	30880902	30880952	16995	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-26				GCTGCTCAGTCCCTCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30540635148713657					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848991	30849041	30881214	30881264	16996	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-27				ACACCTCCAGCCTCCAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32154587800058781					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848385	30848435	30880608	30880658	16997	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-28				AGAATTCACTTCCTTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48302145180116141					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848610	30848660	30880833	30880883	16998	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-29				CTTTGTCTGGGGTCTCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50809159202321519					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848722	30848772	30880945	30880995	16999	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-3				GGAGCGGGACTTGGTTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4027068428938006					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848658	30848708	30880881	30880931	17000	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-30				GCCTGGCTGTGGAGAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4930603699250349					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848599	30848649	30880822	30880872	17001	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-31				GTCTGGGGTTTCTTTGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3428915734672312					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848777	30848827	30881000	30881050	17002	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-32				AGCTGCTCCTCCTGGGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86394919562926342					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848400	30848450	30880623	30880673	17003	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-33				TGAATTCTCAGGGGCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01368434538238154					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848925	30848975	30881148	30881198	17004	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-34				TGAACTGGGAGGGCAGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.911993632012606					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848481	30848531	30880704	30880754	17005	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-35				CGGAGAAAGAGGCAGAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37491200058898178					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848967	30849017	30881190	30881240	17006	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-36				CCTTGTGGGCAGGGACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02836998332524724					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848938	30848988	30881161	30881211	17007	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-37				CAGGAGTGGGCACTGGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1423072459618739					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848533	30848583	30880756	30880806	17008	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-38				GGGGTGGTGGCCGGGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.6711367350166011					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30849004	30849054	30881227	30881277	17009	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-39				CTGGAGGTGTGTTGGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48406349522482989					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848549	30848599	30880772	30880822	17010	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-4				ACAGAAAGCGGCATTGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27787942316239822					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848892	30848942	30881115	30881165	17011	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-40				CTGAGCTGGAGGTGAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9638171288121269					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848317	30848367	30880540	30880590	17012	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-41				TGTCTCAAAAATATTATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848561	30848611	30880784	30880834	17013	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-42				GAGGCAGAGGAAACAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32393737317236632					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848367	30848417	30880590	30880640	17014	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-5				CTCTCCAGGGTGCAAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25785364388724169					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848414	30848464	30880637	30880687	17015	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-6				GTCCTTTAGAGACTCCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33758439813773822					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848881	30848931	30881104	30881154	17016	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-7				CTAAGAGAATCCTGAGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1865596717564654					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848811	30848861	30881034	30881084	17017	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-8				CGGACAAAGCCAGGCAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27883575481439088					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139865	chr6	30848839	30848889	30881062	30881112	17018	hg38	N/A	enh100493	N/A	N/A	enhancer	OCT4e-6-9				CAGGCCTTTGGGGTCGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77870595762451067					DDR1	chr6	30876420	30900156	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1453
enhrx-139864	chr6	30731948	30731998	30764171	30764221	17019	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-1				ACATGTTCTCGAATCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61117183581978829					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732010	30732060	30764233	30764283	17020	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-10				GCATAGTTTGTGGAACTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49291107790846261					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731959	30732009	30764182	30764232	17021	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-11				TCGAGAACATGTAGGGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77445617376571252					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731688	30731738	30763911	30763961	17022	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-12				GTGATTTAGGATGACTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82423665797500156					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731709	30731759	30763932	30763982	17023	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-13				GGCTCCATGTTCAGGCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.018436190670145309					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731851	30731901	30764074	30764124	17024	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-14				AACAGGGCTCTAAGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84735484012801943					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731804	30731854	30764027	30764077	17025	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-15				CTCATTTCAAATAGGTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74842237242195375					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731675	30731725	30763898	30763948	17026	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-16				TGCATGGCTCTTTGTGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39911083830418909					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732287	30732337	30764510	30764560	17027	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-17				GGAGAATTATTTCATAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46100741264810219					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731868	30731918	30764091	30764141	17028	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-18				GGCTGCCTGCAGGAAGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022536262252407929					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732113	30732163	30764336	30764386	17029	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-19				GATTCTTTTGTCTGCTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50372859828564054					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731758	30731808	30763981	30764031	17030	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-2				GTCTGTGGACCTACTAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096184997359947039					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731758	30731808	30763981	30764031	17031	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-2				GTCTGTGGACCTACTAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096184997359947039					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732069	30732119	30764292	30764342	17032	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-20				ATGAGGTTAAATAAACAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8166861332422356					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731883	30731933	30764106	30764156	17033	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-21				AGGCAGCCATGTGCCCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46930463838979319					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732021	30732071	30764244	30764294	17034	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-22				GGAACTCTGGGGGAGCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.4294756706173279					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731790	30731840	30764013	30764063	17035	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-23				TGAAATGAGCAGAAATGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051085912183072582					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731930	30731980	30764153	30764203	17036	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-24				CGGGGGGCAGCTGAGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.278333333061114					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732089	30732139	30764312	30764362	17037	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-25				TGGAAGCCAGAGCTCAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73124805466732534					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731913	30731963	30764136	30764186	17038	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-26				AAGGGGAGGACAGGGGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079588495196663486					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731981	30732031	30764204	30764254	17039	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-27				GAGAACTGGTGTTGGTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53934371392364855					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731894	30731944	30764117	30764167	17040	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-28				TGCCCTGCTGGGGGCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.531086432672975					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731724	30731774	30763947	30763997	17041	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-29				TTTGTCCTTCTCTTTCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53506715667887739					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731773	30731823	30763996	30764046	17042	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-3				TTACGGGTTACTTCTGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78082072173740824					IER3	chr6	30743198	30744548	19184				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731773	30731823	30763996	30764046	17043	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-3				TTACGGGTTACTTCTGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78082072173740824					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732243	30732293	30764466	30764516	17044	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-30				TTGGAGGCAGGAGGAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.785177178437555					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732261	30732311	30764484	30764534	17045	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-31				ACAGGAAGCAGCAGGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39018487565103582					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732052	30732102	30764275	30764325	17046	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-32				ATTAAAAATACTGACAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.21447461538204					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731837	30731887	30764060	30764110	17047	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-33				GCCACATCTGGCTGCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.966798381640215					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732356	30732406	30764579	30764629	17048	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-34				TTTTCTATTTTCCTAAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.869471690626499					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732330	30732380	30764553	30764603	17049	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-35				ACCTGCCCCATTAGTCACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19748625055546751					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732367	30732417	30764590	30764640	17050	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-36				TCTCAAACTGGCCGATGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1383422418226961					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732474	30732524	30764697	30764747	17051	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-37				TTGCTGGTTTTGCGGCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2124279844425345					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732525	30732575	30764748	30764798	17052	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-38				GGGAGTGTGTGAATAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.672082498676918					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732440	30732490	30764663	30764713	17053	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-39				GGGAGACATCACATGTTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.34489254349011					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732141	30732191	30764364	30764414	17054	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-4				CTGCTGCCACTAGACACCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36803383759761821					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732420	30732470	30764643	30764693	17055	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-40				TTTTAAAGCTGGGCATCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.500868195187062					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732504	30732554	30764727	30764777	17056	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-41				TTAGGGATTTTCAAAAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28814411191827138					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732490	30732540	30764713	30764763	17057	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-42				AATCCCTAATAAAAACTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1374492696250163					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732409	30732459	30764632	30764682	17058	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-43				AAAGAGAGAAATTTTAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732379	30732429	30764602	30764652	17059	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-44				TGTCCCTTTATTTCTCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17685898408681511					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732306	30732356	30764529	30764579	17060	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-5				CAGGTGTGAGGTGATTATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64574995611171127					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30731825	30731875	30764048	30764098	17061	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-6				GGAAGTCTCTCTGCCACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34836735379285683					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732162	30732212	30764385	30764435	17062	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-7				GGCACTGAACTTTCCAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27952696005005712					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732224	30732274	30764447	30764497	17063	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-8				CACTTAAGTGCTAGACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1629427182236024					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732224	30732274	30764447	30764497	17064	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-8				CACTTAAGTGCTAGACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1629427182236024					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732179	30732229	30764402	30764452	17065	hg38	N/A	enh23148	fant22171	Enhatls149518	enhancer	OCT4e-7-9				CAGGGGAGCTACATGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72708821027629988					IER3	chr6	30743198	30744548	19457				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139864	chr6	30732179	30732229	30764402	30764452	17066	hg38	N/A	enh23148	N/A	Enhatls149518	enhancer	OCT4e-7-9				CAGGGGAGCTACATGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72708821027629988					IER3	chr6	30743198	30744548	19901				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1452
enhrx-139783	chr6	30415165	30415215	30447388	30447438	17067	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-1				ATTCCCGATCTCACCACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16492779462993881					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415415	30415465	30447638	30447688	17068	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-10				GACATTGTCAGACACAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31127722386447809					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415312	30415362	30447535	30447585	17069	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-11				GGGAATGACAAAGCCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29320011755642278					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415195	30415245	30447418	30447468	17070	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-12				GAGAGGCATATGAGTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058378216430915723					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415063	30415113	30447286	30447336	17071	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-13				GGGAGGCTTCTGTTCCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61332906150605049					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415273	30415323	30447496	30447546	17072	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-14				GGGCTGCTCTGAAGCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062429297381095532					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415300	30415350	30447523	30447573	17073	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-15				TTGTCATTCCCTTCCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20968846876447289					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415284	30415334	30447507	30447557	17074	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-16				AAGCCCAGAGGGCACCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29467716833996521					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415328	30415378	30447551	30447601	17075	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-17				GCCTGGGGTCACAGGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089989643697418173					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415373	30415423	30447596	30447646	17076	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-18				TTTCTTTCACTTTGTAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80143386435178088					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415346	30415396	30447569	30447619	17077	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-19				AGAGGAGAGAGGCAGACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65953630300888466					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415231	30415281	30447454	30447504	17078	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-2				AACCTGCACACTAGCTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21617389065099091					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415178	30415228	30447401	30447451	17079	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-20				CCACTGGAGGGAGGTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8329809597107607					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415121	30415171	30447344	30447394	17080	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-3				TCCAATGGATTTTCTATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58626136039830878					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415253	30415303	30447476	30447526	17081	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-4				TGCCCTGCAGATTCTCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.238296288584244					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415136	30415186	30447359	30447409	17082	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-5				CACTGAGTCTCCAAGTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01785213376993398					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415399	30415449	30447622	30447672	17083	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-6				CAATGTCTTGAGTGACTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8366079120471771					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415104	30415154	30447327	30447377	17084	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-7				ACTAGGACATGCTCATCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46154436007558058					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415087	30415137	30447310	30447360	17085	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-8				CTACTTCACAGAAGATGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2453852600188916					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30415048	30415098	30447271	30447321	17086	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-8-9				GTGCAGAATTGAAGCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.053766234815416043					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379521	30379571	30411744	30411794	17087	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-1				TGGGCGGGCTTGACTGATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39220880946868258					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379362	30379412	30411585	30411635	17088	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-10				GCCCTGTCCAGGCATGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047880666714391992					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379308	30379358	30411531	30411581	17089	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-11				AGATAGGAGCTGAAGGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2256565248625482					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379409	30379459	30411632	30411682	17090	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-12				GGTAACGCCAGTGCCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2132359846005763					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379506	30379556	30411729	30411779	17091	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-13				GATGTCGGGCCTTCCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58946786215676628					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379277	30379327	30411500	30411550	17092	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-14				ATTATAACCTAGAAAAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83820414941824573					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379455	30379505	30411678	30411728	17093	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-15				AAAGGGAGTCTCCCTTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34967483878728139					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379397	30379447	30411620	30411670	17094	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-16				CTGGCGTTACCGCCAGACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.312901232768215					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379373	30379423	30411596	30411646	17095	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-17				GCCCTCTAGTGGCCCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1148167644811348					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379292	30379342	30411515	30411565	17096	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-18				AAACCAGGCCATACAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28706192299445549					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379569	30379619	30411792	30411842	17097	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-19				CACTGAAGCACAGCATCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53021774021275836					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379385	30379435	30411608	30411658	17098	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-2				CACTAGAGGGCTCCTTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28533764352854307					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379434	30379484	30411657	30411707	17099	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-3				TTCCCGATCTGCTGAGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2025754059680529					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379492	30379542	30411715	30411765	17100	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-4				CACAAGAGGTGGTGGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30226169704657052					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379422	30379472	30411645	30411695	17101	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-5				TGAGTGATGGGTGCCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26712613598786261					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379547	30379597	30411770	30411820	17102	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-6				GAGACGTTTAGTCCTCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36376255614910791					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379600	30379650	30411823	30411873	17103	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-7				GTGGAACATGAGAGTCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5489809125999614					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379532	30379582	30411755	30411805	17104	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-8				CAAGCCCGCCCACAGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2247163362179454					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139783	chr6	30379467	30379517	30411690	30411740	17105	hg38	N/A	N/A	N/A	Enhatls149434	enhancer	OCT4e-9-9				TCTCTAACTCCCCCGGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73105830818110529					HLA-E	chr6	30489508	30494194	41161				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1371
enhrx-139933	chr6	31140707	31140757	31172930	31172980	17106	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-1				GGTCTGCCGGAAGGTCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26423221834323118					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140649	31140699	31172872	31172922	17107	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-10				CTCAAAAAGTCTACACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43128530877945709					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140268	31140318	31172491	31172541	17108	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-11				GTTTGCAAGAGAATAGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018180295759786611					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139550	31139600	31171773	31171823	17109	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-12				ATGTGCAGGTTCCATAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89477849718641611					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139617	31139667	31171840	31171890	17110	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-13				AGGGAGAACGGGGCCTACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.830691982426927					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140006	31140056	31172229	31172279	17111	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-14				CTAGATACCTAGGTCCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45814432678011008					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140526	31140576	31172749	31172799	17112	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-15				GGCTCTATCTGCCTTCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.608591020299593					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140537	31140587	31172760	31172810	17113	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-16				GGGACACCCATCCCCTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2866943743684569					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139802	31139852	31172025	31172075	17114	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-17				AGGGTTAGAGCTGCCCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.8019349329111716					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139919	31139969	31172142	31172192	17115	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-18				TCCCCTTCAGAGACGCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79480594668047488					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139779	31139829	31172002	31172052	17116	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-19				GGACCGGGATTGTCCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.72174377534229					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141007	31141057	31173230	31173280	17117	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-2				GCTTGGGAAGAGCGCTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.95887923890645					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140058	31140108	31172281	31172331	17118	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-20				GGAGGGACGCACGATGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3489874706451119					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140672	31140722	31172895	31172945	17119	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-21				TGAAATGCACGCATACAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.951099688002806					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139604	31139654	31171827	31171877	17120	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-22				CAGACATCTAATACCACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0317371718429598					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140911	31140961	31173134	31173184	17121	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-23				CCAAGAAGACGGCCTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2342940398855151					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140154	31140204	31172377	31172427	17122	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-24				AGTGATTTGTGGAGGCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.25939552297881					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141023	31141073	31173246	31173296	17123	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-25				GGGACTCTCTGGACTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.569576218531655					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139822	31139872	31172045	31172095	17124	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-26				CAAGGGTTGAGCACTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.36571550427027					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140184	31140234	31172407	31172457	17125	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-27				AGACCCTGAAGGGGAGCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1149028636362259					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140860	31140910	31173083	31173133	17126	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-28				TGCCGTGATGGTTCTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7985592618863451					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140694	31140744	31172917	31172967	17127	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-29				AATACCTGCCACAGGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7027251765094					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139833	31139883	31172056	31172106	17128	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-3				GCTCAACCCTTGAATGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0029802404223014632					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140330	31140380	31172553	31172603	17129	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-30				CCAAAACTTGATCTCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75091616709735942					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140022	31140072	31172245	31172295	17130	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-31				TATCTAGTTCCTCCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.05732456851635					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140295	31140345	31172518	31172568	17131	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-32				AAACATCATCCCTCACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.97554322601564747					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140099	31140149	31172322	31172372	17132	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-33				GGGATGTGCTTTGTTTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.80924293472611					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140079	31140129	31172302	31172352	17133	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-34				CCCCGAGCCTGGCAGATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2678198996929479					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140782	31140832	31173005	31173055	17134	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-35				GGTAGATTATGGGGCCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.697443775392959					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140402	31140452	31172625	31172675	17135	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-36				CCACAGCTTCGAAGGCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.9117093474121629					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139586	31139636	31171809	31171859	17136	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-37				GTCTGAGTTTTGGTTGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4838904800193249					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139564	31139614	31171787	31171837	17137	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-38				GAGCAAGGAACCTGATGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.319518370701487					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140771	31140821	31172994	31173044	17138	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-39				CCCAAAAGGCAGGTAGATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.15264519547934					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140449	31140499	31172672	31172722	17139	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-4				AGCCTTACTTAAGTCGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0230616752752359					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140223	31140273	31172446	31172496	17140	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-40				GCATGAGCCTCAGGATACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98642918891503373					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141052	31141102	31173275	31173325	17141	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-41				TTTAGGAGCCACTAGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.3874146772024343					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141092	31141142	31173315	31173365	17142	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-42				ACAAGAGGGTGGTGTTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.395053463492627					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139969	31140019	31172192	31172242	17143	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-43				CGTCTGAGGCTCAGTCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.694184304364413					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140628	31140678	31172851	31172901	17144	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-44				GGAGATGGGCACACGAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.409990101241229					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140354	31140404	31172577	31172627	17145	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-45				GGAGCCCCCAGACTTACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4713671205921042					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141034	31141084	31173257	31173307	17146	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-46				AATGGGCAGCAGGGACTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9292134003747841					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140564	31140614	31172787	31172837	17147	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-47				GCCACCAAGATGAAGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.254732727151026					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139668	31139718	31171891	31171941	17148	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-48				TTTTCCCCACCCAGGGCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2061777806587171					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140468	31140518	31172691	31172741	17149	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-49				GGCTTCTCATTGCAGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.67658914452768					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139980	31140030	31172203	31172253	17150	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-5				GAGCCTCAGACGGGCACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.711431249451558					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139725	31139775	31171948	31171998	17151	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-50				ACTTCAGGTTCAAAGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48895045004235671					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140949	31140999	31173172	31173222	17152	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-51				GGAGATTCCAGCCAAATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.270434966582652					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140949	31140999	31173172	31173222	17153	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-51				GGAGATTCCAGCCAAATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.270434966582652					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139946	31139996	31172169	31172219	17154	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-52				GGATTGCAGAGGGGGGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62755455073262423					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140613	31140663	31172836	31172886	17155	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-53				AACAGAGGCAACATAAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24808965739847549					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140038	31140088	31172261	31172311	17156	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-54				TGGACGCCTGAGTCCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.78708531327162					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139846	31139896	31172069	31172119	17157	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-55				ATGGGCCTGGATGGCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.8402271790386138					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139957	31140007	31172180	31172230	17158	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-56				AGTCTTTGAGGGGATTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.207121126272765					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140844	31140894	31173067	31173117	17159	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-57				TCCTGGGGATTGAGATGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5464978850547526					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139992	31140042	31172215	31172265	17160	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-58				GGCACCAAGGGCCCCCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01165947901532271					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140738	31140788	31172961	31173011	17161	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-59				TTGCAGCTGTGTTCACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2547141432335081					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140738	31140788	31172961	31173011	17162	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-59				TTGCAGCTGTGTTCACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2547141432335081					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140284	31140334	31172507	31172557	17163	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-6				CTCACAGACAGGCATTCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3570337727907358					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140975	31141025	31173198	31173248	17164	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-60				GATGGCAAGCTGAGAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52739252979432361					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140975	31141025	31173198	31173248	17165	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-60				GATGGCAAGCTGAGAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52739252979432361					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140123	31140173	31172346	31172396	17166	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-61				TGGCTGGCAGAAAGACGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3532340402086021					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141069	31141119	31173292	31173342	17167	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-62				GAAATTGGGGAAGGTGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.2588141883164918					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139899	31139949	31172122	31172172	17168	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-63				GGATTCTGTGTGAGGGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71278719039638627					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140589	31140639	31172812	31172862	17169	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-64				GAAAAGTCTCAAAAGACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45544857144135431					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140900	31140950	31173123	31173173	17170	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-65				TCTGCTGTCTGCCAAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8932598662464328					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140883	31140933	31173106	31173156	17171	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-66				AGCAGAGAGATGCATGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1860581148908111					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140796	31140846	31173019	31173069	17172	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-67				ATGTTCCTCCCACCCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73651328644567826					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31141103	31141153	31173326	31173376	17173	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-68				ATAATCTAAAAACAAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7137187619504308					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140505	31140555	31172728	31172778	17174	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-69				GGCTTGTCTGCTGGGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096969271269222279					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140809	31140859	31173032	31173082	17175	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-7				GGAGGAACATGCTTCGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3424245061782383					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140425	31140475	31172648	31172698	17176	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-70				CAGCGTGCCCAGTCCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62701892468842169					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139864	31139914	31172087	31172137	17177	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-71				GGGAGCAGGAAGCAGTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1197507845657659					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140195	31140245	31172418	31172468	17178	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-72				CCTTCAGGGTCTGTTTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5721006470913					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139710	31139760	31171933	31171983	17179	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-73				GAGAAAAAATATCTGACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16331364132980969					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139736	31139786	31171959	31172009	17180	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-74				AAAGAAGCCTGGGAGGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.674386364426705					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140993	31141043	31173216	31173266	17181	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-75				CTTTTGGGGAACCTGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.10979486213155					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139762	31139812	31171985	31172035	17182	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-76				AGGGGGCAGGACAATGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45847974255831148					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139680	31139730	31171903	31171953	17183	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-77				GGTGGGGAAAACCAGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81927641453900657					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139652	31139702	31171875	31171925	17184	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-78				TGGCCCAGGCCTCCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2328346080429369					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140143	31140193	31172366	31172416	17185	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-79				AGGAGGTGGAGAGTGATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47525806246583979					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140757	31140807	31172980	31173030	17186	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-8				TCGGCCTTTAACTGCCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8756507306796779					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140757	31140807	31172980	31173030	17187	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-8				TCGGCCTTTAACTGCCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8756507306796779					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140369	31140419	31172592	31172642	17188	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-80				GGGGCTCCAGAGGGGGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.6701570833920418					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140923	31140973	31173146	31173196	17189	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-81				GCCCCTCCCCCTCCTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.35485574717082					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140938	31140988	31173161	31173211	17190	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-82				GGAGGGGCAGGCCTGGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9409070627206626					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140938	31140988	31173161	31173211	17191	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-82				GGAGGGGCAGGCCTGGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9409070627206626					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140484	31140534	31172707	31172757	17192	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-83				CTCCAGGCTCAGCCCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9483834377688249					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139885	31139935	31172108	31172158	17193	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-84				GGGATTGGGACTGGGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.8370433012619931					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139641	31139691	31171864	31171914	17194	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-85				AGGCCTGGGCCAGGGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4467307079829					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139691	31139741	31171914	31171964	17195	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-86				TCTCCACACCCCCCACCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55894623711346625					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139749	31139799	31171972	31172022	17196	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-87				AGGGACTGGGGGAAGGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.3190099271533349					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31139628	31139678	31171851	31171901	17197	hg38	N/A	enh46102	N/A	N/A	enhancer	OCT4e+1-88				GGAGGTGGGGGAGGGAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76439665734850781					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139933	chr6	31140872	31140922	31173095	31173145	17198	hg38	N/A	enh46102	fant22196	N/A	enhancer	OCT4e+1-9				GCATGACAAAGGTGCCGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3607396848934732					POU5F1	chr6	31164336	31180731	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1521
enhrx-139944	chr6	31275773	31275823	31307996	31308046	17199	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-1				CGGACTTAAAGTGTCCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070048945109787528					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275697	31275747	31307920	31307970	17200	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-10				CGGCTCAAAGAGCGGCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01263057540018914					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275761	31275811	31307984	31308034	17201	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-11				CTTTAAGTCCGCCTACGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2443096097759552					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276059	31276109	31308282	31308332	17202	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-12				GAACCGGGCTGGTCACTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15700879171889109					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275787	31275837	31308010	31308060	17203	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-13				CCTTCGAGGAAGCTCCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35860498129337959					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276362	31276412	31308585	31308635	17204	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-14				AGTACCCGGGGTGCGGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43656913754655369					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275738	31275788	31307961	31308011	17205	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-15				AGATTTCATGTCCCTGAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31043860289294228					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276500	31276550	31308723	31308773	17206	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-16				TCCGGTGCCGGGCGGGACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.89433057424231					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275750	31275800	31307973	31308023	17207	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-17				ACATGAAATCTCCTTGTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1542514143481597					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275660	31275710	31307883	31307933	17208	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-18				GGAGAGGTTCTGGACCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83700068766961466					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275681	31275731	31307904	31307954	17209	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-19				TTGGAGGATCCATCACACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.312628301731826					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276386	31276436	31308609	31308659	17210	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-2				TCCGGGAACCCGCACATTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.608196483676053					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275985	31276035	31308208	31308258	17211	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-20				CGCTGGGGCCATTTTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034462516772239778					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276046	31276096	31308269	31308319	17212	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-21				AGCCCGGTTCTCCCAGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072893833295896424					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276263	31276313	31308486	31308536	17213	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-22				CGCCGCGGCTGTGGAAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.096659810043445052					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276166	31276216	31308389	31308439	17214	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-23				CGCAGGGAATGTGTTACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53970424766314262					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275957	31276007	31308180	31308230	17215	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-24				TCAGTCATGATCCAGATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57793589920373467					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276531	31276581	31308754	31308804	17216	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-25				CTTGGGAGCTTCTTACTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3329227299920145					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276464	31276514	31308687	31308737	17217	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-26				CGTCGCCCTGCCTCCCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1177427397632277					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275727	31275777	31307950	31308000	17218	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-27				GGTCTGCAGGTCCTCGTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81947201190879859					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276121	31276171	31308344	31308394	17219	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-28				TCACCGGCTGACCCTGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.127720665550501					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276401	31276451	31308624	31308674	17220	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-29				ATTGCGGGCGGGAGAGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1037120400389679					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276248	31276298	31308471	31308521	17221	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-3				TCACGCTCTGATTCTCGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2011137479515793					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276000	31276050	31308223	31308273	17222	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-30				TCTCAGGTGGGGAAGCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0005950751311761					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276012	31276062	31308235	31308285	17223	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-31				TCAGCTGATCCCTCTCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1851625310989769					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276328	31276378	31308551	31308601	17224	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-32				GGGCTCCGCCTTCACCACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.298042689313879					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276094	31276144	31308317	31308367	17225	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-33				ACACCTGTGCCCGGAGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22775960326130171					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275931	31275981	31308154	31308204	17226	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-34				GTTCTGTGACCAATGACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39519107657615438					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276228	31276278	31308451	31308501	17227	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-35				TGAAGCGCGGGTGGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59539573800840306					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275834	31275884	31308057	31308107	17228	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-36				CATCTGCAGGTGCGGTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3157918612191829					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276142	31276192	31308365	31308415	17229	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-37				GGTGCGGGCCCAGGAACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92539504054890231					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276448	31276498	31308671	31308721	17230	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-38				GGCGACGGCGTCCAGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0690200617790273					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275714	31275764	31307937	31307987	17231	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-39				GAGCCGCTGTCCAGGTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050107190104747949					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276285	31276335	31308508	31308558	17232	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-4				GAATCGCGTGTCGCCCACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48352989981989841					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275968	31276018	31308191	31308241	17233	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-40				TCCAGGTTTCTCCTTCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14475840709878829					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276542	31276592	31308765	31308815	17234	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-41				CTTACTGTGTGGGGGGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52250398927687969					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276214	31276264	31308437	31308487	17235	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-42				AGAAGATGGCACAGGGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14593803986786641					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276070	31276120	31308293	31308343	17236	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-43				GTCACTCTGGGGTCGGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.262113880839943					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275801	31275851	31308024	31308074	17237	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-44				GCTGGGTGGTGGCTCCGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24908724998053069					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275858	31275908	31308081	31308131	17238	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-45				CCTGCCCCAGGGTGAGCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33090041806649789					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276427	31276477	31308650	31308700	17239	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-46				GGCGAGCGGGGCGGCGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42263622877540591					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275818	31275868	31308041	31308091	17240	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-47				GCAGATGCTGCTGTCTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32410667317907					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276478	31276528	31308701	31308751	17241	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-48				GAGGGAGGCTGTGTCCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45592451921981608					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275886	31275936	31308109	31308159	17242	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-49				GGCGACCTCCCTCCCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.29176316470959					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276305	31276355	31308528	31308578	17243	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-5				AGGCGCCGCGGAGGAACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15223842003363					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275869	31275919	31308092	31308142	17244	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-50				GTGAGCCGGAGGCGGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048083755495755227					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275847	31275897	31308070	31308120	17245	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-51				GGTGCCCTGGACCTGCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8464706768294841					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276035	31276085	31308258	31308308	17246	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-52				GGCCCCGCCCCCCCATCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094956690529687068					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275918	31275968	31308141	31308191	17247	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-53				TGACAGAGGGAGGAAGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7584096278377377					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31275907	31275957	31308130	31308180	17248	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-54				GGAAGGAGCTGGGGTGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.48434691697771					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276348	31276398	31308571	31308621	17249	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-6				CCCGGCGGCCTTCAAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33291722749291092					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276514	31276564	31308737	31308787	17250	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-7				GGCACCGGAGCCGCTCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3736476793423904					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276105	31276155	31308328	31308378	17251	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-8				CGGAGTCTGAGGTCACTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.530410887260384					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139944	chr6	31276182	31276232	31308405	31308455	17252	hg38	N/A	enh49077	N/A	Enhatls149600	enhancer	OCT4e+2-9				GAAAGTTCTCGAAGACCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079944185621805844					HLA-C	chr6	31268748	31272092	33957				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1532
enhrx-139948	chr6	31334718	31334768	31366941	31366991	17253	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-1				GACGCGCGGCCAAGATTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096713397134364054					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334868	31334918	31367091	31367141	17254	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-10				GGGCTGTGCGTGATCTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.585832821178187					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335086	31335136	31367309	31367359	17255	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-11				CCGTGAAGGCGCCTGTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.04678775902287					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334968	31335018	31367191	31367241	17256	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-12				AAAGAAGCGTGAGGTTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.575254006658042					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334957	31335007	31367180	31367230	17257	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-13				TCACGCTTCTTTTGCTTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.04697549861609273					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335114	31335164	31367337	31367387	17258	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-14				ACCCGCTCCCTCTACACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51144853538065294					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334630	31334680	31366853	31366903	17259	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-15				CGTCGCTGTGTCTCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18030766889178951					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334939	31334989	31367162	31367212	17260	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-16				ACAGGAAGATTGACGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0852403404096942					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334672	31334722	31366895	31366945	17261	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-17				GGAGCTCACCGCTGCTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25830788523667469					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334672	31334722	31366895	31366945	17262	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-17				GGAGCTCACCGCTGCTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25830788523667469					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335054	31335104	31367277	31367327	17263	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-18				GCCTTACTCCCCATGCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30638129057658092					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334995	31335045	31367218	31367268	17264	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-19				AATGGTGTTATCTCCACCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57355009605747					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334701	31334751	31366924	31366974	17265	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-2				CGCGTCCTGGTGTAGCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024327770071980091					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334701	31334751	31366924	31366974	17266	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-2				CGCGTCCTGGTGTAGCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024327770071980091					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334831	31334881	31367054	31367104	17267	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-20				AGCAGCGCAGCAGCGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1566303992664641					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335032	31335082	31367255	31367305	17268	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-21				CCGTGTTCAGGGGAAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75937658496927873					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335097	31335147	31367320	31367370	17269	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-22				GCGGGTCCTCACCTCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3261647099197611					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334801	31334851	31367024	31367074	17270	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-23				CGTCCTGGGCATCCACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50397675126435859					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335072	31335122	31367295	31367345	17271	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-24				AGAGGAGGCTCTGGCCGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.140397427262546					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335132	31335182	31367355	31367405	17272	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-25				GATGGCCAAGAGCCTGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32691667417913423					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334816	31334866	31367039	31367089	17273	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-26				GCGCTGCTTCTGCTCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56032345329389588					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334889	31334939	31367112	31367162	17274	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-27				AGGAAGGAGAGGTGGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36074038111244178					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334889	31334939	31367112	31367162	17275	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-27				AGGAAGGAGAGGTGGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36074038111244178					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335144	31335194	31367367	31367417	17276	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-28				AAGCCTTCCCTGCCATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1951135204344675					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334771	31334821	31366994	31367044	17277	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-29				AGGTGGAGAGAGGGATGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.178814940958506					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334913	31334963	31367136	31367186	17278	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-3				CGCACCACGCATTTCTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38968241163692352					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334913	31334963	31367136	31367186	17279	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-3				CGCACCACGCATTTCTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38968241163692352					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335021	31335071	31367244	31367294	17280	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-4				GATCCATGTCACCGTGTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62800477110176933					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334846	31334896	31367069	31367119	17281	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-5				GAAGCGCATCGACCACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26934152848422083					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31335008	31335058	31367231	31367281	17282	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-6				GACATGGATCTCGCCAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17353143169306171					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334788	31334838	31367011	31367061	17283	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-7				GCCCAGGACGAGCTTTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2056280054160064					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334733	31334783	31366956	31367006	17284	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-8				TTGGCCGGAAGGTTTTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43809654577809531					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334900	31334950	31367123	31367173	17285	hg38	N/A	enh100494	fant22198	Enhatls149604	enhancer	OCT4e+3-9				GCGTGGTGCGTAGGAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7592018821619656					HLA-B	chr6	31353874	31367067	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-139948	chr6	31334900	31334950	31367123	31367173	17286	hg38	N/A	enh100494	N/A	Enhatls149604	enhancer	OCT4e+3-9				GCGTGGTGCGTAGGAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7592018821619656					HLA-B	chr6	31353874	31367067	78				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1536
enhrx-lit385	chr6	31371303	31371353	31403526	31403576	17287	hg38					enhancer	OCT4e+4-1				GTTTCATTGGATGAGCGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2774710952711687													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit386	chr6	31371169	31371219	31403392	31403442	17288	hg38					enhancer	OCT4e+4-10				CCGCGTGCTCCCCATTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016992348296796141													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit387	chr6	31371193	31371243	31403416	31403466	17289	hg38					enhancer	OCT4e+4-11				AGATTTAGAAGGCGGGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60745352906459538													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371524	31371574	31403747	31403797	17290	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-12				GACGTTTCCGGGGGTCGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96243892177773693					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-139950	chr6	31371512	31371562	31403735	31403785	17291	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-13				CGGGAGCAGTGGGACGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42779819501682409					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit388	chr6	31371364	31371414	31403587	31403637	17292	hg38					enhancer	OCT4e+4-14				AGCGGCTCAAGCAGTGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28001213464985442													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371550	31371600	31403773	31403823	17293	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-15				CGGCGAGCGCTGTGCGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31588000031551139					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-139950	chr6	31371586	31371636	31403809	31403859	17294	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-16				AGCTCCCTGCGCCACCGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3370815070149995					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit389	chr6	31371393	31371443	31403616	31403666	17295	hg38					enhancer	OCT4e+4-17				GTGGCGACGTCGGGGCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.261389283243919													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit390	chr6	31371236	31371286	31403459	31403509	17296	hg38					enhancer	OCT4e+4-18				GGAATTTTCTCTTCCAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19490404399200209													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit391	chr6	31371274	31371324	31403497	31403547	17297	hg38					enhancer	OCT4e+4-19				TCGTGATTGGCCCTAAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37044196882337249													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit392	chr6	31371382	31371432	31403605	31403655	17298	hg38					enhancer	OCT4e+4-2				CGACGTCGCCACCCTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0012633048001257511													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371487	31371537	31403710	31403760	17299	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-20				GCGTTCCTGGCGGTCCTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.373719037401957					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit393	chr6	31371025	31371075	31403248	31403298	17300	hg38					enhancer	OCT4e+4-21				TGGTGAGGCCCGCGCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3799069342826053													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371452	31371502	31403675	31403725	17301	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-22				GCAGCTCCCGGAGGTGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2611300594703303					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit394	chr6	31371060	31371110	31403283	31403333	17302	hg38					enhancer	OCT4e+4-23				GGATGGGTGGTCGCGATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23837381252289341													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit395	chr6	31371005	31371055	31403228	31403278	17303	hg38					enhancer	OCT4e+4-24				GGCGGCCGGCGAAAGGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52224567018197021													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371663	31371713	31403886	31403936	17304	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-25				GGTGATGCGCGATCCCGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02390936189067009					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit396	chr6	31371138	31371188	31403361	31403411	17305	hg38					enhancer	OCT4e+4-26				TCGAAGCTGGTCCCTGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1743174533731715													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371648	31371698	31403871	31403921	17306	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-27				CGAGGAGGACTGAAAAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14142576141354651					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit397	chr6	31371418	31371468	31403641	31403691	17307	hg38					enhancer	OCT4e+4-28				GGGCCCGGTCTTTCTGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70131522193023266													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit398	chr6	31371347	31371397	31403570	31403620	17308	hg38					enhancer	OCT4e+4-29				TTTCCGCGGCGCCTTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41982247008467261													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit399	chr6	31370993	31371043	31403216	31403266	17309	hg38					enhancer	OCT4e+4-3				CGCCGGCCGCCCCATTAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19630925187623291													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371618	31371668	31403841	31403891	17310	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-30				GGGCTGAAGTGTGGCGGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22478858692990419					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-139950	chr6	31371474	31371524	31403697	31403747	17311	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-31				CTGCTGGTGAGTGGCGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23574649599794539					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit400	chr6	31371204	31371254	31403427	31403477	17312	hg38					enhancer	OCT4e+4-32				GAGACCTGGGGAGATTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46526103445007638													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit401	chr6	31371218	31371268	31403441	31403491	17313	hg38					enhancer	OCT4e+4-33				ATTCCAGTGGGCTGGAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.247994736431594													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit402	chr6	31371073	31371123	31403296	31403346	17314	hg38					enhancer	OCT4e+4-34				CGATGCCGGGAGGGCAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2228420919535381													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit403	chr6	31371316	31371366	31403539	31403589	17315	hg38					enhancer	OCT4e+4-35				AGCGGTCGGGGGACCGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64535500598903217													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371501	31371551	31403724	31403774	17316	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-36				CCTCGGCGGAGCGGGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.259670711209542					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-139950	chr6	31371575	31371625	31403798	31403848	17317	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-37				GGGCTCCTGTGCCCTGTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51817894205887716					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit404	chr6	31371125	31371175	31403348	31403398	17318	hg38					enhancer	OCT4e+4-38				TACTCTCAGCTACTCGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23197802259869491													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371704	31371754	31403927	31403977	17319	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-39				GACGCGAGGAGAGAAAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045712510975848157					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit405	chr6	31371334	31371384	31403557	31403607	17320	hg38					enhancer	OCT4e+4-4				GCCGCGGAAACTTAGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2061651976750182													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit406	chr6	31371039	31371089	31403262	31403312	17321	hg38					enhancer	OCT4e+4-40				CTCCTCGGGGTGGGGGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65699738619324366													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit407	chr6	31371249	31371299	31403472	31403522	17322	hg38					enhancer	OCT4e+4-41				GGAGAGGGCGGGGCCACGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0068962472526832956													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit408	chr6	31371180	31371230	31403403	31403453	17323	hg38					enhancer	OCT4e+4-42				GGGACCTGGGGCCCAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066460931983721439													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-139950	chr6	31371675	31371725	31403898	31403948	17324	hg38	N/A	N/A	N/A	Enhatls149606	enhancer	OCT4e+4-5				CGCGCATCACCTGCACTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2041646350904438					MICA	chr6	31399783	31415315	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1538
enhrx-lit409	chr6	31371149	31371199	31403372	31403422	17325	hg38					enhancer	OCT4e+4-6				CGGGAGCGCAGCCTAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042451703556744019													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit410	chr6	31371096	31371146	31403319	31403369	17326	hg38					enhancer	OCT4e+4-7				CAACTTCATAAGCACGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.170225270412194													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit411	chr6	31371260	31371310	31403483	31403533	17327	hg38					enhancer	OCT4e+4-8				CAATCACGAGCGGAGAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99942493780933583													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit412	chr6	31371290	31371340	31403513	31403563	17328	hg38					enhancer	OCT4e+4-9				GTTCCGGGCCCCAGTTTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25027410742605932													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit413	chr6	31651135	31651185	31683358	31683408	17329	hg38					enhancer	OCT4e+5-1				TCACTCGGTTGCTTACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49204295345339982													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit414	chr6	31651055	31651105	31683278	31683328	17330	hg38					enhancer	OCT4e+5-10				AGGGCGTTGAATAATCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.47680364393309													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit415	chr6	31651108	31651158	31683331	31683381	17331	hg38					enhancer	OCT4e+5-11				AGTGCTCCTACCTAGAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.253543142421874													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit416	chr6	31651281	31651331	31683504	31683554	17332	hg38					enhancer	OCT4e+5-12				CTCGAGATTGCGTTCTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01773331368572352													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit417	chr6	31651347	31651397	31683570	31683620	17333	hg38					enhancer	OCT4e+5-13				GATTCCTGAAGAATCCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.873828949897276													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit418	chr6	31650994	31651044	31683217	31683267	17334	hg38					enhancer	OCT4e+5-14				GTCCAGAGAGTTCGTTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.006759128888608106													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit419	chr6	31651359	31651409	31683582	31683632	17335	hg38					enhancer	OCT4e+5-15				ATCCGGAATGGCTTGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24267795892297561													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit420	chr6	31651182	31651232	31683405	31683455	17336	hg38					enhancer	OCT4e+5-16				GGACAGAACGCCAAGGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01268527866707821													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit421	chr6	31650891	31650941	31683114	31683164	17337	hg38					enhancer	OCT4e+5-17				GGCCGCGCCCCCTCCGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20674429098973479													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit422	chr6	31651204	31651254	31683427	31683477	17338	hg38					enhancer	OCT4e+5-18				GAATGGAGCCAGGCAAACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4445022577811571													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit423	chr6	31651120	31651170	31683343	31683393	17339	hg38					enhancer	OCT4e+5-19				TAGAGTTAAGGGATACCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2229467199689936													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit424	chr6	31650978	31651028	31683201	31683251	17340	hg38					enhancer	OCT4e+5-2				TCTGGACTCTTAGCGCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13642875992007741													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit425	chr6	31651072	31651122	31683295	31683345	17341	hg38					enhancer	OCT4e+5-20				GTCATCTGCTGCTGTCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22791569100694131													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit426	chr6	31650928	31650978	31683151	31683201	17342	hg38					enhancer	OCT4e+5-21				GAGCAAAACGCAACAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38093859132127139													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit427	chr6	31651039	31651089	31683262	31683312	17343	hg38					enhancer	OCT4e+5-22				ACGCCCTGCCTCTTCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32844878050597													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit428	chr6	31651161	31651211	31683384	31683434	17344	hg38					enhancer	OCT4e+5-23				AACAAAGAAGGCGGGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2400911764679057													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit429	chr6	31650949	31650999	31683172	31683222	17345	hg38					enhancer	OCT4e+5-24				TCCTCTCCTGTCCACCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70767303947325666													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit430	chr6	31651325	31651375	31683548	31683598	17346	hg38					enhancer	OCT4e+5-25				CCTAAATATAAATGAATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42440099959185662													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit431	chr6	31651294	31651344	31683517	31683567	17347	hg38					enhancer	OCT4e+5-26				TCTAGAGAGGAACCAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051118062909593413													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit432	chr6	31650878	31650928	31683101	31683151	17348	hg38					enhancer	OCT4e+5-27				GGGCAGGGTGGGGCCTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1608807693741161													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit433	chr6	31650964	31651014	31683187	31683237	17349	hg38					enhancer	OCT4e+5-28				GCGCCCTGGGCTGGCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26554999097754522													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit434	chr6	31651371	31651421	31683594	31683644	17350	hg38					enhancer	OCT4e+5-29				TTGTTGATTGGATAGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16630670539959361													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit435	chr6	31651235	31651285	31683458	31683508	17351	hg38					enhancer	OCT4e+5-3				GTAGATGACCCGGTCGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96608079120789025													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit436	chr6	31651011	31651061	31683234	31683284	17352	hg38					enhancer	OCT4e+5-4				CTTCGCGGAACCCGTCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27489895547115													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit437	chr6	31650912	31650962	31683135	31683185	17353	hg38					enhancer	OCT4e+5-5				AGACGGGATTAATTACTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25469872990661568													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit438	chr6	31651149	31651199	31683372	31683422	17354	hg38					enhancer	OCT4e+5-6				ACCGAGTGACGAAACAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15952554556360471													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit439	chr6	31651306	31651356	31683529	31683579	17355	hg38					enhancer	OCT4e+5-7				TAGGTTAAAGACCCTCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23802173739342011													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit440	chr6	31651259	31651309	31683482	31683532	17356	hg38					enhancer	OCT4e+5-8				GCCGCTCCCCCAACAAACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21454715677456321													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit441	chr6	31651026	31651076	31683249	31683299	17357	hg38					enhancer	OCT4e+5-9				TCACCCCAGGAAAACCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59711736524561232													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit442	chr8	55370249	55370299	54457689	54457739	17358	hg38					enhancer	positive control 1				CGAGTCTCCCTAACCCCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	13.2620583401158													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit443	chr8	55370295	55370345	54457735	54457785	17359	hg38					enhancer	positive control 2				GCTCCGGCTAGTTTTCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	13.192886725468879													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit444	chr8	55370437	55370487	54457877	54457927	17360	hg38					enhancer	positive control 3				ATGTGGCCAATGGAGCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	11.32076132356204													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77941	chr18	45453031	45453081	47926660	47926710	17361	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-1				CTAAGCTTTAAGCTATGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4181593375689272					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452957	45453007	47926586	47926636	17362	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-10				TTCTAACAAGCAAAGTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43142664372316408					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452819	45452869	47926448	47926498	17363	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-11				AAACAGATAACAGCTCGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059129839407441577					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452884	45452934	47926513	47926563	17364	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-12				AGGCTTAGAGGGGGTGTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68198444086618126					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452896	45452946	47926525	47926575	17365	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-13				GGGTACTGTGGGAGGCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.668803880053318					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452840	45452890	47926469	47926519	17366	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-14				TTTTTCTGACAAGAGACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31636406257802813					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452870	45452920	47926499	47926549	17367	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-15				TGTGGTGGGGGCTGGGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9078243145686591					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452908	45452958	47926537	47926587	17368	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-2				CAAGTAGATTATGGGTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17489440099683171					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452761	45452811	47926390	47926440	17369	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-3				AAAGCCTGACTAGCATGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38098904426385521					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452722	45452772	47926351	47926401	17370	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-4				CATTACTATGCTTTCAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44788145008238273					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452690	45452740	47926319	47926369	17371	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-5				CAATTAGCCTAAATCATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.453696559411101					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452737	45452787	47926366	47926416	17372	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-6				AGGTCTGGTCCTGCACTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3605852154089284					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452926	45452976	47926555	47926605	17373	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-7				ACTTGTTTCTAATCTAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.753047464515478					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45452996	45453046	47926625	47926675	17374	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-8				GACCCTTAATAAGAATGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25724822521583057					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45453020	45453070	47926649	47926699	17375	hg38	N/A	enh4830	N/A	Enhatls83615	enhancer	SMAD2e-1-9				CTTAAAGCTTAGGAGAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49555457671138131					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77859	chr18	44116606	44116656	46536643	46536693	17376	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-1				CTCACGCACCATGACATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25810963469886739					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116526	44116576	46536563	46536613	17377	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-10				CTTCATTGATAAAAACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.250764223625483					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116798	44116848	46536835	46536885	17378	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-11				CTGATAGGAAACAAAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22919998677426071					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116809	44116859	46536846	46536896	17379	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-12				GTTTCCTATCAGAAAATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.132856298311897					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116666	44116716	46536703	46536753	17380	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-13				CTTTTAACGAGAAAATTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.331271789388743					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116557	44116607	46536594	46536644	17381	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-14				CTGAGGCTGTGATCACACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2406160217809421					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116769	44116819	46536806	46536856	17382	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-15				TAGAGACTGGCCCAGGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.688392562783774					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116780	44116830	46536817	46536867	17383	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-16				CAGGGCACCTTCCTTCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86378659394315216					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116731	44116781	46536768	46536818	17384	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-17				TGCTCTCTTCCCACCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.06915093917262187					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116540	44116590	46536577	46536627	17385	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-2				ACTCCCCGGAAGTCATGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1112519431357553					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116756	44116806	46536793	46536843	17386	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-3				GCATCCCCCGGGATAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86136675181836131					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116574	44116624	46536611	46536661	17387	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-4				CCTCAGCCGCTGACGGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14959885390027761					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116713	44116763	46536750	46536800	17388	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-5				TCTGGAGCAGTCAGCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58309927119476934					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116502	44116552	46536539	46536589	17389	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-6				ATTATAGCTGTCTATTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7359045507991671					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116678	44116728	46536715	46536765	17390	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-7				CTCGTTAAAAGACTCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37937084372217711					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116631	44116681	46536668	46536718	17391	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-8				GATGAGATGTTAGCTTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21283123626986639					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77859	chr18	44116744	44116794	46536781	46536831	17392	hg38	N/A	N/A	N/A	Enhatls83532	enhancer	SMAD2e-10-9				GAAGAGAGCAAGGCATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89029814784685046					LOXHD1	chr18	46476971	46657220	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1877
enhrx-77847	chr18	44049554	44049604	46469591	46469641	17393	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-1				CAAGGTTAAGGTATGGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.09406453485406216					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049912	44049962	46469949	46469999	17394	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-10				AACACTTCCTAAGCCCTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.641848000506727					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049654	44049704	46469691	46469741	17395	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-11				TGTTGAAACAGGGCTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55361462227015568					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049740	44049790	46469777	46469827	17396	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-12				AGCTGGTTCCAAAAGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016199515100302011					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049507	44049557	46469544	46469594	17397	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-13				AGGTCAAAAGCCCAGAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.038798853851087133					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049668	44049718	46469705	46469755	17398	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-14				GTTTCAACAGCTTGCTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095535466893262172					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049726	44049776	46469763	46469813	17399	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-15				GAACCAGCTCAGCACTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51689115133251584					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049491	44049541	46469528	46469578	17400	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-16				TTGACCTTGCAGCCTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23021446044963109					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049583	44049633	46469620	46469670	17401	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-17				AGAGCCCTGGCTGGAATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1040422979198					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049683	44049733	46469720	46469770	17402	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-18				TTCTGAGGCTGAAGTTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31382553739063029					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049597	44049647	46469634	46469684	17403	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-19				AATACCAGGGAAGAGGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43428505359567932					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049542	44049592	46469579	46469629	17404	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-2				CATCAGCAAAGACAAGGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13614404339254291					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049570	44049620	46469607	46469657	17405	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-20				CGGGAGGGGGAGTAGAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18642595201919959					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049863	44049913	46469900	46469950	17406	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-21				AGAGTTACAAACCTAATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4659159993705611					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049519	44049569	46469556	46469606	17407	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-22				CAGAGCTTTGGGAGAGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1399970272465809					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049712	44049762	46469749	46469799	17408	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-23				CTCTGCAGGGAGAGGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029322544998995139					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049790	44049840	46469827	46469877	17409	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-24				TTTCAGATTTTTGTCTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.200958078632979					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049925	44049975	46469962	46470012	17410	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-25				CAGTGTCTGGCACCCAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27088475844830068					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049801	44049851	46469838	46469888	17411	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-3				TGTCTTTGTTGGAGTCATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26899821784885619					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049636	44049686	46469673	46469723	17412	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-4				TTACCTTTATCATCTAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14073768131547951					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049457	44049507	46469494	46469544	17413	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-5				CTAGGAGGCTCCCCAGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.495226990966512					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049694	44049744	46469731	46469781	17414	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-6				AAGTTTTCTTGGCAATAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31298891226835512					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049874	44049924	46469911	46469961	17415	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-7				TTTCAGCCCTACCACTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4964671937452721					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049767	44049817	46469804	46469854	17416	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-8				CTTGGAGAGCTGAAAGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035609593344536151					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77847	chr18	44049472	44049522	46469509	46469559	17417	hg38	N/A	enh75982	N/A	Enhatls83520	enhancer	SMAD2e-11-9				ATGGCAGAAGGCTCCCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61655112653274					ARK2C	chr18	46326808	46463140	1183				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1865
enhrx-77842	chr18	44013821	44013871	46433858	46433908	17418	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-1				GTGCGGGAGGAAATTTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72250121027512459					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013485	44013535	46433522	46433572	17419	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-10				GCGGAGGTGGGGACCCGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.065624982981271937					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013696	44013746	46433733	46433783	17420	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-11				GAGCACTGTCCTGATCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1752122550247518					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-lit445	chr18	44013321	44013371	46433358	46433408	17421	hg38					enhancer	SMAD2e-12-12				CGGGGTCAGCGACTGGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.297818947306991													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit446	chr18	44013303	44013353	46433340	46433390	17422	hg38					enhancer	SMAD2e-12-13				CAGGGCGCCGCTGTGCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44329586221381789													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77842	chr18	44013639	44013689	46433676	46433726	17423	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-14				ACTTCCTACAGAGACCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71383388580326479					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013560	44013610	46433597	46433647	17424	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-15				GCCCGGGTGTGGCGGAGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0098240348903529621					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013682	44013732	46433719	46433769	17425	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-16				ACAGTGCTCACTGCCTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31576203564203259					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013656	44013706	46433693	46433743	17426	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-17				GGAAGTAGCTATTGTTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62808641388462783					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013439	44013489	46433476	46433526	17427	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-18				GCGAGACCAGCCTGCGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.086092970070629049					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013804	44013854	46433841	46433891	17428	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-19				CAGTGGACTCCTGCATGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31375995394578959					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013669	44013719	46433706	46433756	17429	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-2				GTTTCAGAGGCATCCACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022013080662176339					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013462	44013512	46433499	46433549	17430	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-20				ACCCCAGGTTGGTGCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35671777459975512					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013753	44013803	46433790	46433840	17431	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-21				ATCACCCAGGTGCAGGGTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060093910627132673					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013549	44013599	46433586	46433636	17432	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-22				ACGAGGGCGTGGCCCGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24444727602529651					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013723	44013773	46433760	46433810	17433	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-23				GGACACACACTGGCTTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.025733956461131351					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013451	44013501	46433488	46433538	17434	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-24				GCTGGTCTCGCACCCCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52602127343918981					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-lit447	chr18	44013373	44013423	46433410	46433460	17435	hg38					enhancer	SMAD2e-12-25				AGGTCCCTCCTTCCTACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2422276954742523													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit448	chr18	44013396	44013446	46433433	46433483	17436	hg38					enhancer	SMAD2e-12-26				CAGGAGGTATTGCTGGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060064518261673548													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77842	chr18	44013573	44013623	46433610	46433660	17437	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-27				GGAGACGGGGGCGGGGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1064367207813544					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013610	44013660	46433647	46433697	17438	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-28				GCTTCTCTCCCTGGCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24407704586989551					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013533	44013583	46433570	46433620	17439	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-29				CGTGGGCAGGGCCAGGACGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020039327905101888					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013768	44013818	46433805	46433855	17440	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-3				GGTCGGGGACGGGTAACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27027769969358789					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-lit449	chr18	44013339	44013389	46433376	46433426	17441	hg38					enhancer	SMAD2e-12-30				GAACTGCAGGGTGGGCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6879924599435061													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77842	chr18	44013473	44013523	46433510	46433560	17442	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-31				GTGCTGCCTGGGGCGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35971883796324688					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013509	44013559	46433546	46433596	17443	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-32				TCGGGTGAGGGGGCAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37115877226818772					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-lit450	chr18	44013385	44013435	46433422	46433472	17444	hg38					enhancer	SMAD2e-12-33				GCTGGTGCAGGGCCTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15253647306752571													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit451	chr18	44013415	44013465	46433452	46433502	17445	hg38					enhancer	SMAD2e-12-34				CTTCCAGGAGCTGCTGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10237693768524569													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77842	chr18	44013521	44013571	46433558	46433608	17446	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-35				GCAGGGCCAGGGCGTGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30688341718945472					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013624	44013674	46433661	46433711	17447	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-4				CCTGGCCGGCAGTCACCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.195567684826106					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013497	44013547	46433534	46433584	17448	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-5				ACCCGGATGGGGTCGGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4219007808852071					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013740	44013790	46433777	46433827	17449	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-6				GTGTCCCCATTGCATCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1367083694239527					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-lit452	chr18	44013353	44013403	46433390	46433440	17450	hg38					enhancer	SMAD2e-12-7				CTGCAGTTCCAGGACGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0041818942106941594													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77842	chr18	44013787	44013837	46433824	46433874	17451	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-8				GTGGTCCACGATCCTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84019210551793932					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77842	chr18	44013588	44013638	46433625	46433675	17452	hg38	N/A	N/A	N/A	Enhatls83515	enhancer	SMAD2e-12-9				GCTACAGGCTCCTAGACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0816424767136529					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1860
enhrx-77841	chr18	44004954	44005004	46424991	46425041	17453	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-1				AAGACAGGACAGCCGGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14495399101589					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005178	44005228	46425215	46425265	17454	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-10				CGGGGAACCCCAGAGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21655870458229051					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005069	44005119	46425106	46425156	17455	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-11				TCCCTGTTCTGCCCCAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60928753796900992					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44004988	44005038	46425025	46425075	17456	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-12				TCTCCAAAGGCACCAGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48774910495814772					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005107	44005157	46425144	46425194	17457	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-13				GCTCAGTAGCTGAGCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021149748800203271					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44004942	44004992	46424979	46425029	17458	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-14				AGCCTCTCCAGCCCTGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29761919009984511					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005058	44005108	46425095	46425145	17459	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-15				GCAGAACAGGGAGGGGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7599460643141729					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005041	44005091	46425078	46425128	17460	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-16				CACTGGAGGCAGGGCCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07540003436148783					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005080	44005130	46425117	46425167	17461	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-17				CTCACTCTTCCCCAGTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.021131103931574569					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005140	44005190	46425177	46425227	17462	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-18				GCCTCCTCAGGCCAGCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.148200689096764					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44004976	44005026	46425013	46425063	17463	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-19				TCTTTCTCCCTGCCCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.2799697928734926					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005196	44005246	46425233	46425283	17464	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-2				GATGGGATCCAAACCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89003533072820229					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005001	44005051	46425038	46425088	17465	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-3				GCCCGAGACTCCCTCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27071973573866043					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005152	44005202	46425189	46425239	17466	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-4				GCCCGAGTTCCCGCCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54141022835342978					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44004924	44004974	46424961	46425011	17467	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-5				AGGCTCAGCCTCAAGAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3405425919104425					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005209	44005259	46425246	46425296	17468	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-6				GGATCCCATCCTACTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2060879889413296					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005129	44005179	46425166	46425216	17469	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-7				GAAACCTGACACCTGAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42138168805344811					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005027	44005077	46425064	46425114	17470	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-8				CCCCTCCTTTCTGACCATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2715884668533266					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	44005230	44005280	46425267	46425317	17471	hg38	N/A	N/A	N/A	Enhatls83514	enhancer	SMAD2e-13-9				GGATCCCACATCCCTGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75955770187830807					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999694	43999744	46419731	46419781	17472	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-1				GTCCGTCTCCAGTTACCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31276147996407289					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999874	43999924	46419911	46419961	17473	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-10				TCAGTGGAAATACATGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62794381815568323					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999679	43999729	46419716	46419766	17474	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-11				GGGGCTGATGGAGCCCCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15187139216111281					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999647	43999697	46419684	46419734	17475	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-12				AGGCAGGGCAGTCACAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0373221190073521					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999660	43999710	46419697	46419747	17476	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-13				ACAAGGCAGGGGCAGCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33122383361293189					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999839	43999889	46419876	46419926	17477	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-14				AAAGAAGGTTAGAGGAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60973914094283543					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999808	43999858	46419845	46419895	17478	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-15				GATAACAAAAGGATGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.467470149738914					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999631	43999681	46419668	46419718	17479	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-16				GGCCAACAGGGGTGGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0586158001654011					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999797	43999847	46419834	46419884	17480	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-17				GATGCAAAGAGGAAGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6818596068773486					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999777	43999827	46419814	46419864	17481	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-18				AGGGAGGAGATGCCTGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18839295709971141					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999903	43999953	46419940	46419990	17482	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-19				GTGCATGAGAGAAAAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57788545430724692					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999574	43999624	46419611	46419661	17483	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-2				ATATTAAGCAATGAGCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1158081295123302					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999819	43999869	46419856	46419906	17484	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-20				AGGGGAAGAGAGATAACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5947772180402779					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999854	43999904	46419891	46419941	17485	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-21				AGGAAGACAGGAAAGAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3214144045969326					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999890	43999940	46419927	46419977	17486	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-3				AAAGAGACGGTGGACGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37738526729079669					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999720	43999770	46419757	46419807	17487	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-4				ATATGCCTAACAAGCAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5322502418474111					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999937	43999987	46419974	46420024	17488	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-5				TGTCTAGCACTCTGGGGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69469369225266087					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999757	43999807	46419794	46419844	17489	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-6				AGGCAGAGCTATAGGCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.054800765775542548					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999618	43999668	46419655	46419705	17490	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-7				CCTACCTGGGGAAGGCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43541161242230519					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999604	43999654	46419641	46419691	17491	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-8				ACAGCTGGACCAGGCCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23070687293227041					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43999589	43999639	46419626	46419676	17492	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-14-9				CGGAGTGGGCAGCGCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20659425109244989					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988892	43988942	46408929	46408979	17493	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-1				CGGGCAGCTAGGCAATGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988691	43988741	46408728	46408778	17494	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-10				GACAGCAATTCCCTAATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071269100335977581					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988638	43988688	46408675	46408725	17495	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-11				GTCAGAATTTGAAGGGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51082890262968594					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988588	43988638	46408625	46408675	17496	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-12				GGGACACTTAACAGAGTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2227403605886327					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988541	43988591	46408578	46408628	17497	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-13				AGCACATCATGGGAACTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.227155368848688					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988679	43988729	46408716	46408766	17498	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-14				CTAATGGCTGGTGTGTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42348860802165822					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988667	43988717	46408704	46408754	17499	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-15				GTGTTCTAAGGATGTGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1739986385599778					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988811	43988861	46408848	46408898	17500	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-16				AAACAGATAACAGTACCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27096508625042592					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988829	43988879	46408866	46408916	17501	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-17				TGTTTTCTGAGTCATCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60187521735191873					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988709	43988759	46408746	46408796	17502	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-18				CTGTCAGATCAGTTTGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1183415041131075					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988616	43988666	46408653	46408703	17503	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-19				AGTTAATTAGAGCATCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82402100360497432					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988477	43988527	46408514	46408564	17504	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-2				GACTACGGGTAAGTTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.347059707337271					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988847	43988897	46408884	46408934	17505	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-20				ACAGGACTTTCTGCAAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26600995261634891					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988729	43988779	46408766	46408816	17506	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-21				TGGTCTTATCTTGGAACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59700163026738617					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988521	43988571	46408558	46408608	17507	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-22				GCTCTCTTCCTCCCCGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24196652655006989					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988744	43988794	46408781	46408831	17508	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-23				ACAGATGGTTGTGAATGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.281070680503795					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988878	43988928	46408915	46408965	17509	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-24				ATGAACAGGGAACTGAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.460183278017354					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988491	43988541	46408528	46408578	17510	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-3				CCCGTAGTCAAACAGAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31791234170734689					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988509	43988559	46408546	46408596	17511	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-4				TAAGGTTATCAGCCTGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42331436042421111					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988552	43988602	46408589	46408639	17512	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-5				GGAACTGTGGGGCATCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0853847134542241					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988650	43988700	46408687	46408737	17513	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-6				AGGGTTGCTGGAACAGTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25401782826757868					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988911	43988961	46408948	46408998	17514	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-7				TAAATAGAAGATGGTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20688419986590259					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988796	43988846	46408833	46408883	17515	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-8				GTGATGAGCCTTCATCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08929966600536389					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43988564	43988614	46408601	46408651	17516	hg38	N/A	enh44564	N/A	Enhatls83514	enhancer	SMAD2e-15-9				CATCCTAAAGGGGGCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.901737954456129					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924055	43924105	46344092	46344142	17517	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-1				TCGTCAGGGGAGGCCAACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.492235744045012					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924142	43924192	46344179	46344229	17518	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-10				ACTCAGCACCAGCCTGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2428595443258578					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43923997	43924047	46344034	46344084	17519	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-11				TGTGTGCAGCTGAGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036806317628839541					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924173	43924223	46344210	46344260	17520	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-12				TGGAGGAGCTCTCTGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32098742017379711					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924226	43924276	46344263	46344313	17521	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-13				CAAGGAAGGGCAGGAAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40895806179072208					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924193	43924243	46344230	46344280	17522	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-14				GGGAGGAAGTGAGAATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68363916675067249					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924154	43924204	46344191	46344241	17523	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-15				TCCACCCCCTCTCCACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0167016958400264					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924273	43924323	46344310	46344360	17524	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-16				GCTGAGTGGGAGGGAAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.110055452727611					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924070	43924120	46344107	46344157	17525	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-2				CTAAGGGATACAGTGTCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20062889529174541					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924086	43924136	46344123	46344173	17526	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-3				AGGCCAGCACTTAGATCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0671769171748331					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924042	43924092	46344079	46344129	17527	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-4				AGGGGGACAGTCACCCACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10840135478289691					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924212	43924262	46344249	46344299	17528	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-5				GTGGACACCTGTCTCAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13647938395973719					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924260	43924310	46344297	46344347	17529	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-6				TGCCCCCTCTGAAGCTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36082903957284318					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924099	43924149	46344136	46344186	17530	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-7				GTGCTGGCCTCACTGCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01958150785902555					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924110	43924160	46344147	46344197	17531	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-8				ACTGCACCTAGGAAAGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5482779730844038					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77841	chr18	43924019	43924069	46344056	46344106	17532	hg38	N/A	enh48121	N/A	Enhatls83514	enhancer	SMAD2e-16-9				GAAGTCCTCCCTGCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.479649207215191					ARK2C	chr18	46326808	46463140	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1859
enhrx-77839	chr18	43874017	43874067	46294054	46294104	17533	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-1				GGCGAGATGCCAATGGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49228527552221168					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874092	43874142	46294129	46294179	17534	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-10				CACCCTCCTTTGTCTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14620890734937009					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873912	43873962	46293949	46293999	17535	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-11				ACCATTGGAAATAACAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072413234793276451					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874042	43874092	46294079	46294129	17536	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-12				TGGCTGGGCTGGATTTCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.89532527956754626					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873956	43874006	46293993	46294043	17537	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-13				GGAAGGAATATTCTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2126539175265304					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874188	43874238	46294225	46294275	17538	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-14				GAGGGGAGAGCCATACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25016084599977728					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874248	43874298	46294285	46294335	17539	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-15				AGCCCCCCAGCATCCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.07921719964431391					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874108	43874158	46294145	46294195	17540	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-16				AAGCTGGGGAAACTGGTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0611548621732851					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874070	43874120	46294107	46294157	17541	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-17				GGTCCCAGCTCCAGCCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39377205674639948					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874169	43874219	46294206	46294256	17542	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-18				TCTGGGGGCTGTTCTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061686135931550791					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874235	43874285	46294272	46294322	17543	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-19				GGGAAGCCTGGAACCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54235272866619888					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874151	43874201	46294188	46294238	17544	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-2				CACCCGCGCTCTGTCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092378256070021481					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873939	43873989	46293976	46294026	17545	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-20				TCAGACAAGGGTGAAGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89658997709353938					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874267	43874317	46294304	46294354	17546	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-21				GGCTGGGGGTGGGTTTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57902767658423637					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873853	43873903	46293890	46293940	17547	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-3				TAAGTGAGTTATCTCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59339925203378607					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873893	43873943	46293930	46293980	17548	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-4				GTGGCTAACATTCTTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2190829019007903					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874133	43874183	46294170	46294220	17549	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-5				GGGTGACACTAGAGACTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.572850323856341					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874215	43874265	46294252	46294302	17550	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-6				CCTTTTCAGCATGAACAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41000470780157833					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874006	43874056	46294043	46294093	17551	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-7				TGGCATCTCGCCTGTGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34981551521756848					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43874057	43874107	46294094	46294144	17552	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-8				GCCTGAAAGGAGATCTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61160332867166023					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43873927	43873977	46293964	46294014	17553	hg38	N/A	enh4824	N/A	Enhatls83512	enhancer	SMAD2e-17-9				CCAATGGTGACATCAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44536733466021372					ARK2N	chr18	46173552	46266992	22171				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863626	43863676	46283663	46283713	17554	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-1				CTCAAGGCGGTGAGCCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3304838868616537					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863895	43863945	46283932	46283982	17555	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-10				GAATTAGATTATCAGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13817101917429461					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864134	43864184	46284171	46284221	17556	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-11				GCCGTGGTCCTGCCTCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38241314054403641					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864234	43864284	46284271	46284321	17557	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-12				ACGTGCCAGAAATATTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5508932471112844					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863829	43863879	46283866	46283916	17558	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-13				GATGAGGGCCCTGATTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2212327899214134					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863573	43863623	46283610	46283660	17559	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-14				TCAGCTGGGTTCTGGTAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14541293492096821					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864167	43864217	46284204	46284254	17560	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-15				GAAAAACCACTTGGCCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23553479284287071					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863859	43863909	46283896	46283946	17561	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-16				ACACAATTCAATTACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20610320280672209					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863612	43863662	46283649	46283699	17562	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-17				CACAACACAACCCTCCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14945805798497169					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864260	43864310	46284297	46284347	17563	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-18				GGGGCTTTCTATGATTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25698043412294619					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864078	43864128	46284115	46284165	17564	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-19				ACCGGGAGAAGCTGACTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14351261066342649					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863688	43863738	46283725	46283775	17565	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-2				GTCATGGATTGCTAGTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2294980098715641					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863720	43863770	46283757	46283807	17566	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-20				ATTTCAGTTGCCACAGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67883586712872346					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863814	43863864	46283851	46283901	17567	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-21				GTCAGACAGATGTAGGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16799412068524319					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863733	43863783	46283770	46283820	17568	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-22				CAACTGAAATATTAAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3632569961391468					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863649	43863699	46283686	46283736	17569	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-23				GACAATCGCTGAGGTCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.317029542801437					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863755	43863805	46283792	46283842	17570	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-24				GAAGCTGAAAAGTGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.112469810737958					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863523	43863573	46283560	46283610	17571	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-25				TCGTGCATGTTCCCACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42684644711389308					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863988	43864038	46284025	46284075	17572	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-26				GTATATCAGTTTCTGTAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65422471984523767					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863967	43864017	46284004	46284054	17573	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-27				ACCCAATGCCCTGAGACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056876605004314643					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863541	43863591	46283578	46283628	17574	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-28				CGGAGGTGTGGGCAAAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23252559868584069					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863803	43863853	46283840	46283890	17575	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-29				CATCTGTCTGACAAAACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36801743485765942					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863660	43863710	46283697	46283747	17576	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-3				TCAGCGATTGTCCTGGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17849171594957841					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863877	43863927	46283914	46283964	17577	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-30				AATTCTCAACAAGTCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11301511447853289					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863950	43864000	46283987	46284037	17578	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-31				TCTCACAGGATTGCCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.691955265443152					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863485	43863535	46283522	46283572	17579	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-32				AGAAGTAAGTCTGCCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43170208524354292					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864018	43864068	46284055	46284105	17580	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-33				CTCCACCTCTCTTGCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66244485011445475					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864122	43864172	46284159	46284209	17581	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-34				ATGACACCAGCACCCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37916072270472923					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863936	43863986	46283973	46284023	17582	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-35				AAAGGGTGGAAACTTCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0094162478273061					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864042	43864092	46284079	46284129	17583	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-36				CAGCTGGGCTGAGCCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15034988408361741					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864096	43864146	46284133	46284183	17584	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-37				TCACCTCTACCTCCAGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.356923865327879					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864065	43864115	46284102	46284152	17585	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-38				GACTGGAGGGGATTTGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6423663761109909					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863773	43863823	46283810	46283860	17586	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-39				TCTTGGGAGGGGCAGAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97808425353030959					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864150	43864200	46284187	46284237	17587	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-4				TTTTTCTAGAGCACTGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.426931290137887					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863671	43863721	46283708	46283758	17588	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-40				CATGACTGCTGCCCACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029207648112708619					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863587	43863637	46283624	46283674	17589	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-41				GGAGGGGATGATGGTCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.093142137672377334					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863558	43863608	46283595	46283645	17590	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-42				TAGACAGGGAGGAAAGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44648649246733713					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863906	43863956	46283943	46283993	17591	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-43				TCAGCCCCTGGGGGCTCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29821117781649331					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864181	43864231	46284218	46284268	17592	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-5				CACAGTAAGGGAGTCCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.333282693833845					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863918	43863968	46283955	46284005	17593	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-6				GGCTCGGTGGGAGAGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3632788768181381					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43863789	43863839	46283826	46283876	17594	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-7				AACACTAGGCCAGGCATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25943499364601691					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864211	43864261	46284248	46284298	17595	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-8				GGCCATGTTAGGTGCTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17795659641371411					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77839	chr18	43864194	43864244	46284231	46284281	17596	hg38	N/A	enh17658	N/A	Enhatls83512	enhancer	SMAD2e-18-9				ATGGCCATAGGCACACAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41891459052865337					ARK2N	chr18	46173552	46266992	5011				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1857
enhrx-77838	chr18	43841767	43841817	46261804	46261854	17597	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-1				ATTAAGCCTTTGTAGGAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.295180977397498					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841894	43841944	46261931	46261981	17598	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-10				CCAAAGCTGAAATTCTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10097956175249349					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841732	43841782	46261769	46261819	17599	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-11				TTAGGAATTTTTCTTAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35200268439592491					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841950	43842000	46261987	46262037	17600	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-12				CAGCTGCTCAGGAGCCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37428104503626192					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841939	43841989	46261976	46262026	17601	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-2				AGATTGTCAAACAGCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24236537561512941					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841779	43841829	46261816	46261866	17602	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-3				TAGGAGTAGGGCATGTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40074254536567228					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841813	43841863	46261850	46261900	17603	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-4				TCAGTTGCAAAACTGCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30696984807622368					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841798	43841848	46261835	46261885	17604	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-5				CAGGAGTTTAAGGGTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23460761012822151					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841964	43842014	46262001	46262051	17605	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-6				TAGTCACTAAACTACCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1567361632292914					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841861	43841911	46261898	46261948	17606	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-7				TCTTTTGAATCTGGTGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72126723087427791					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841918	43841968	46261955	46262005	17607	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-8				CTGTAAGCAACAAATAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0455526512003573					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77838	chr18	43841843	43841893	46261880	46261930	17608	hg38	N/A	enh17657	N/A	Enhatls83511	enhancer	SMAD2e-19-9				AAAGAACATTAGGGTAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33601212330653069					ARK2N	chr18	46173552	46266992	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1856
enhrx-77941	chr18	45444598	45444648	47918227	47918277	17609	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-1				GAGATGGCCTGGGTATAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3162307845604264					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444772	45444822	47918401	47918451	17610	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-10				ATCTATATGCCTTTCCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44017375461607361					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444445	45444495	47918074	47918124	17611	hg38	N/A	enh52736	N/A	Enhatls83615	enhancer	SMAD2e-2-11				CTATTATTCCTTCCCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74806733331464537					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444828	45444878	47918457	47918507	17612	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-12				CACTGGAGAGGGATCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.478017291359933					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444587	45444637	47918216	47918266	17613	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-13				CCCTGGACTAGGAGATGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.059473683467743					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444783	45444833	47918412	47918462	17614	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-14				AGGCATATAGATGCTAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444875	45444925	47918504	47918554	17615	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-15				CTGATCAAAAACTCAACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61047139257847893					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444679	45444729	47918308	47918358	17616	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-16				AGCCAAAACCCAGTGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040942288708828607					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444916	45444966	47918545	47918595	17617	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-17				CTTAAGAATTACTTTATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1530010413132414					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444475	45444525	47918104	47918154	17618	hg38	N/A	enh52736	N/A	Enhatls83615	enhancer	SMAD2e-2-18				TTGTTAAGAGCTTTGTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93411684853222077					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444954	45445004	47918583	47918633	17619	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-19				AACCAGAAAAATTCAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35195209578515169					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444512	45444562	47918141	47918191	17620	hg38	N/A	enh52736	N/A	Enhatls83615	enhancer	SMAD2e-2-2				ATTTCCGCCCCTACTGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1058793679506538					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444512	45444562	47918141	47918191	17621	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-2				ATTTCCGCCCCTACTGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1058793679506538					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444845	45444895	47918474	47918524	17622	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-20				TTGTCTCCTTTCAGTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69839911700903445					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444576	45444626	47918205	47918255	17623	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-21				GAAAACAAAATCCCTGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0569272506554221					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444609	45444659	47918238	47918288	17624	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-22				GGTATAAGTAGGAAGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1530010413132414					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444427	45444477	47918056	47918106	17625	hg38	N/A	enh52736	N/A	Enhatls83615	enhancer	SMAD2e-2-23				CACGGCAGGAACTGAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6139352228356409					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444722	45444772	47918351	47918401	17626	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-3				TGATCTGAATAACTGGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1182767631096979					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444703	45444753	47918332	47918382	17627	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-4				GAGGTCTGGCTGCTAGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86302097270589639					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444413	45444463	47918042	47918092	17628	hg38	N/A	enh52736	N/A	Enhatls83615	enhancer	SMAD2e-2-5				AACCAACAGCAAGTCACGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0199483808905172					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444755	45444805	47918384	47918434	17629	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-6				CTAGGGTACCTGACCGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3885246466663572					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444813	45444863	47918442	47918492	17630	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-7				TGAGCAGGCAGGCTGTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81688954224452448					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444552	45444602	47918181	47918231	17631	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-8				TCAACGTTTACTTTCTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39304747986893013					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45444738	45444788	47918367	47918417	17632	hg38	N/A	N/A	N/A	Enhatls83615	enhancer	SMAD2e-2-9				CAGATCAAAAGACTTCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9961509164555409					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77834	chr18	43746747	43746797	46166781	46166831	17633	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-1				GAGCTCGTCCTGAATAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65148081737217756					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746724	43746774	46166758	46166808	17634	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-10				CTTTCAGCCACACCTGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0040815546501578237					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746674	43746724	46166708	46166758	17635	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-11				GGATGAGGGCTGGTCACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42214963464044192					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746594	43746644	46166628	46166678	17636	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-12				AACCCCTCTTCCATCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36345037294286242					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746765	43746815	46166799	46166849	17637	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-13				AAAGGACATTCCTACTACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.054690528118205087					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746605	43746655	46166639	46166689	17638	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-14				CATCCTGGGAGGTTGTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65590371659700542					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746835	43746885	46166869	46166919	17639	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-15				TAGAATAAAAAATACGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0893625981194019					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746695	43746745	46166729	46166779	17640	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-16				GAGAGTCCCTATATAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11502834750243821					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746804	43746854	46166838	46166888	17641	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-17				AAGAGCTTTGTGCTAGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020461488366063142					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746658	43746708	46166692	46166742	17642	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-18				AATCATATGGTTGGTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062237635827371539					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746517	43746567	46166551	46166601	17643	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-2				ACTGGAAACTCTCTGACACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0761725666939948					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746645	43746695	46166679	46166729	17644	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-3				CAACCCTCTCTCTAATCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016123119639500211					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746792	43746842	46166826	46166876	17645	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-4				ACAAAGCTCTTAAGAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43181137421654259					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746776	43746826	46166810	46166860	17646	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-5				CTACTACTCAGGAGATCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.333271681965464					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746712	43746762	46166746	46166796	17647	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-6				ACTCTCCAAGAGCCAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.107163903645544					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746546	43746596	46166580	46166630	17648	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-7				GGATTTTACTGAAGTTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049282918934175093					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746563	43746613	46166597	46166647	17649	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-8				AGTTCAATCACCAAAGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0708530424212728					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77834	chr18	43746858	43746908	46166892	46166942	17650	hg38	N/A	N/A	N/A	Enhatls83507	enhancer	SMAD2e-20-9				AGACAAAATTAGGGTATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.93801747176076189					ARK2N	chr18	46173552	46266992	4539				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1852
enhrx-77941	chr18	45428337	45428387	47901966	47902016	17651	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-1				GGAAGCGACTTGAGAACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19943250825371309					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428360	45428410	47901989	47902039	17652	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-10				TGTTGAGATAAAGATTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6196708345310471					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428498	45428548	47902127	47902177	17653	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-11				GTGGCAGATTGGAAATATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48457757384385292					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428533	45428583	47902162	47902212	17654	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-12				TACAGAGTAGAGGAGGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58282277560796991					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428108	45428158	47901737	47901787	17655	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-13				CAGAGTCTCATCCTAGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50436684134741638					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428557	45428607	47902186	47902236	17656	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-14				CAGCTGATCATTGTTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40324547753508538					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428176	45428226	47901805	47901855	17657	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-15				AAGCAATTCTTATAGTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0168641517726531					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428454	45428504	47902083	47902133	17658	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-16				CAGAATTTAGGAATATACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.593817858002027					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428097	45428147	47901726	47901776	17659	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-17				TCTGGTTTGTCCCTGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0355671246719282					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428136	45428186	47901765	47901815	17660	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-18				TCTGCTAGCTTTTGAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.002039709783487032					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428405	45428455	47902034	47902084	17661	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-19				AATCTCCTTTTCTGAGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51696102155413648					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428258	45428308	47901887	47901937	17662	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-2				TGTCTACGGGGGAAGAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8237819201695					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428196	45428246	47901825	47901875	17663	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-20				CTTTGTTTTTAAGAGACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74166930666197373					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428517	45428567	47902146	47902196	17664	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-21				CCACTCAGGCTGCAGCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.655078333688798					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428151	45428201	47901780	47901830	17665	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-3				CTAGCAGATCGTTATCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5527039830419231					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428247	45428297	47901876	47901926	17666	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-4				AATTTGGCAAATGTCTACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8634331509699149					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428315	45428365	47901944	47901994	17667	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-5				GTGAGAGTTGAAAGCGTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4732181903058838					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428383	45428433	47902012	47902062	17668	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-6				TGGGATATTTTCTAGTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45099638325735852					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428231	45428281	47901860	47901910	17669	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-7				GCCTAAGCAGCTTCAGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4555877867385141					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428474	45428524	47902103	47902153	17670	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-8				AGGGCGTTCTCTGTGTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7362377544143179					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77941	chr18	45428442	45428492	47902071	47902121	17671	hg38	N/A	enh4829	N/A	Enhatls83615	enhancer	SMAD2e-3-9				CCAGCTGAACTACAGAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5711303490646449					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1959
enhrx-77937	chr18	45379744	45379794	47853373	47853423	17672	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-1				TACGAATGGGGGCTTCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8359866727312331					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379681	45379731	47853310	47853360	17673	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-10				CTGTTTTTAAGCCTAATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32685404885769948					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379668	45379718	47853297	47853347	17674	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-11				TTAAAAACAGATGCAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90412173677642516					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379826	45379876	47853455	47853505	17675	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-12				CGGAGGTTGCAGTGAGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9419919234482861					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379543	45379593	47853172	47853222	17676	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-13				ACACAAAACTTAGTCGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6644463747284366					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379594	45379644	47853223	47853273	17677	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-14				GGAAGGCTAAGGCAGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.74118057825678					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379852	45379902	47853481	47853531	17678	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-15				CGCCCAGGCTGGAGTGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.76534829316179					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379577	45379627	47853206	47853256	17679	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-16				TGTAATCCCAGCTACTCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9133683004550246					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379512	45379562	47853141	47853191	17680	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-17				GAGATGGGGTTTCACTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1841387577989186					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379527	45379577	47853156	47853206	17681	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-18				TTTGTGTTTTCAGTAGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75298800913120834					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379489	45379539	47853118	47853168	17682	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-19				TCAGGAGTTAGAGACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24008065622270991					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379762	45379812	47853391	47853441	17683	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-2				TGACAATCGAGTAGTACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58218638382179388					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379611	45379661	47853240	47853290	17684	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-3				GAATGGCCGTAGTATACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8233201008530484					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379800	45379850	47853429	47853479	17685	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-4				AGGTCGCCTCGCTTGAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.495208393680769					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379780	45379830	47853409	47853459	17686	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-5				TGTCAAAGTCAAGGAGTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040958135343907319					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379627	45379677	47853256	47853306	17687	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-6				TTTCACTGCTACACGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17372184141440311					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379649	45379699	47853278	47853328	17688	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-7				AGTGGTTTGGTTTAGACGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42256185304177513					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379730	45379780	47853359	47853409	17689	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-8				TGATGTAATTATTATACGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.985436434575897					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77937	chr18	45379692	45379742	47853321	47853371	17690	hg38	N/A	N/A	N/A	Enhatls83610	enhancer	SMAD2e-4-9				TCATGAGCTGTCCCCACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12836533172634021					SMAD2	chr18	47808956	47931146	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1955
enhrx-77933	chr18	45299391	45299441	47773020	47773070	17691	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-1				CATAGTGAGCGGCTGTGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0767726834399419					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299145	45299195	47772774	47772824	17692	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-10				TGGGCAATTGGAAAACCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.926724314393756					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299129	45299179	47772758	47772808	17693	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-11				CCAGACAGGAAGTCGGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38227095087007029					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299402	45299452	47773031	47773081	17694	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-12				ATCTGTGTGACCATAGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.542205190038812					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299361	45299411	47772990	47773040	17695	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-13				AAAACTACTGACCCTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40487331543043					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299015	45299065	47772644	47772694	17696	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-14				TATGGAAGGGAAACCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01032976066543375					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299044	45299094	47772673	47772723	17697	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-15				CAAGAGATGGAGAATGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33507766099839209					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299086	45299136	47772715	47772765	17698	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-16				TGGGAGGAGTTTTTGGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.080910566375388765					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299306	45299356	47772935	47772985	17699	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-17				AAACTTTAAGGAGGCTGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0704348994321098					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299203	45299253	47772832	47772882	17700	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-18				CACAGGCAGTGGCTGATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039059276895389509					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299275	45299325	47772904	47772954	17701	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-19				CTGAAGCAGGAAGGACCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1661954071852875					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299290	45299340	47772919	47772969	17702	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-2				GGCGTGGATGATCTCCCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.079448482309267529					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299217	45299267	47772846	47772896	17703	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-20				CTGCCTGTGTCTCCACTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64843610028541065					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299417	45299467	47773046	47773096	17704	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-21				ACACAGATTCAGAACACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63262689571299646					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299319	45299369	47772948	47772998	17705	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-22				CTTAAAGTTTTGAAAGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32917566374442542					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299101	45299151	47772730	47772780	17706	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-23				TCCTCCCAGAGCCTTTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41763079755511578					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299057	45299107	47772686	47772736	17707	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-24				CTGCCTTCCCTCCCAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17039148904639231					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299344	45299394	47772973	47773023	17708	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-25				AGTTTTCATCGGTTTCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36790070792414442					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299028	45299078	47772657	47772707	17709	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-3				GTTCTGGTCCAAATATGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41369365699414212					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299157	45299207	47772786	47772836	17710	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-4				GCATAGCACCTTTGGGCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17011541388905571					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299229	45299279	47772858	47772908	17711	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-5				CTTTGTTAGGAGCCACGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4491055594275401					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299115	45299165	47772744	47772794	17712	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-6				TTCCTAGGGCTTGTCCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32197998170666953					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299181	45299231	47772810	47772860	17713	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-7				GGCGCCGCCTTCTGGTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.444049863363284					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299378	45299428	47773007	47773057	17714	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-8				TGTGCCGAGGCATTCTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70524771768155281					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45299252	45299302	47772881	47772931	17715	hg38	N/A	enh17660	N/A	Enhatls83606	enhancer	SMAD2e-5-9				CTCTTAACTCCTAAGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21674506264833809					SMAD2	chr18	47808956	47931146	25193				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275737	45275787	47749366	47749416	17716	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-1				ATGCCGCACTGACCCGCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1974726754125444					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275471	45275521	47749100	47749150	17717	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-10				GAATTAGCCGAGTGTTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42038421980375					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275763	45275813	47749392	47749442	17718	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-11				GGAGGCCTACGGATCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55193161281172465					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275707	45275757	47749336	47749386	17719	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-12				ACCAGGGGGCGCCAGAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21095257394892419					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275909	45275959	47749538	47749588	17720	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-13				GAATTCCAGTAACCCTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54529153387502083					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275840	45275890	47749469	47749519	17721	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-14				GGAACCAACATCACACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19918452420099519					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275826	45275876	47749455	47749505	17722	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-15				GTTGGTTCCTTAGCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.025886663806675179					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275610	45275660	47749239	47749289	17723	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-16				AGCCCCGCGCTTCGCGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28314797211347847					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275940	45275990	47749569	47749619	17724	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-17				GTGGATTTAGGGGATTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0939987891688442					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275777	45275827	47749406	47749456	17725	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-18				GAGAGTCGAAGGAGCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22852800455484909					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275855	45275905	47749484	47749534	17726	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-19				CTGGCTGGCCCACGCAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53881115175082228					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275670	45275720	47749299	47749349	17727	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-2				CGCGCCGTCTGGACTGCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53830141581163227					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275626	45275676	47749255	47749305	17728	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-20				TCAGCAGAGCTCAGGGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1694689700118204					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275659	45275709	47749288	47749338	17729	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-21				CCGCCGCGCGCCGCGCCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1205559117760524					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275800	45275850	47749429	47749479	17730	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-22				AAGCAGAGGGCGGGGGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1994729795386779					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275579	45275629	47749208	47749258	17731	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-23				GGCGGCGGCAGCTGCGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0911578231690391					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275788	45275838	47749417	47749467	17732	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-24				GGGGGCGTGGGGAGAGTCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39653217338111157					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275813	45275863	47749442	47749492	17733	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-25				CAGCCCTGGGGAGAAGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.136486905075641					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275597	45275647	47749226	47749276	17734	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-26				GCGCGGGGCTCAGGGCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.274296582016243					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275510	45275560	47749139	47749189	17735	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-27				ATTAGAAAAGCAATAATAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.15257167456885					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275723	45275773	47749352	47749402	17736	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-3				GTGCGGCATCGCGGACACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063913399979249039					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275552	45275602	47749181	47749231	17737	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-4				GAGCGCCGTTCTCTGTTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063396513093017359					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275896	45275946	47749525	47749575	17738	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-5				TGGGATGCGCGAACCTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48007541358875222					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275884	45275934	47749513	47749563	17739	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-6				CGCGCATCCCATTACTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1277812410351839					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275750	45275800	47749379	47749429	17740	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-7				GTAGGCCTCCCGTCCGTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1994709022069					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275696	45275746	47749325	47749375	17741	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-8				CCGCGCGAAACCCGACGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077201088516837449					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77933	chr18	45275929	45275979	47749558	47749608	17742	hg38	N/A	N/A	N/A	Enhatls83606	enhancer	SMAD2e-6-9				TTCGGGATGCTGTGGATTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071253968571505871					SMAD2	chr18	47808956	47931146	43803				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1951
enhrx-77932	chr18	45187166	45187216	47660795	47660845	17743	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-1				CGGGCGCCCCTCCCCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.317870648143452					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45186905	45186955	47660534	47660584	17744	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-10				GCGCGAGCCGAAGCAGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0477479100375739					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45186932	45186982	47660561	47660611	17745	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-12				GCCTCACCTGGGAAGCGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.794738776507685					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187086	45187136	47660715	47660765	17746	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-15				GGCGTAGGACCCTCTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13197517092231961					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187453	45187503	47661082	47661132	17747	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-18				CCCCGAGCAGCCTAACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.099738616569739189					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45186983	45187033	47660612	47660662	17748	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-2				AAAGGGGTGACTGACGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24596546416662191					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187218	45187268	47660847	47660897	17749	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-25				AGCAGCCAGGAAGCTCGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.150515943572237					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187148	45187198	47660777	47660827	17750	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-3				CAAACTGCAAGGCGGCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28289793753712911					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187205	45187255	47660834	47660884	17751	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-33				CTTAGGTAAACAAAGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64635759602083154					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187039	45187089	47660668	47660718	17752	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-4				TTTCAGACTGGCTTAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33525784652753732					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187025	45187075	47660654	47660704	17753	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-5				AGTCTGAAAAGCGCAATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02165282744470598					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187519	45187569	47661148	47661198	17754	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7-9				TTCCAACAGACCTGCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82692093636045927					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77932	chr18	45187414	45187464	47661043	47661093	17755	hg38	N/A	N/A	N/A	Enhatls83605	enhancer	SMAD2e-7/EOMESe+5/+13				GGGCAGACTGCCTCCTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68201605752852779					SMAD2	chr18	47808956	47931146	144278				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1950
enhrx-77901	chr18	44479408	44479458	46899445	46899495	17756	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-1				GCCGAACCAGAGTAATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25120232931351288					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479213	44479263	46899250	46899300	17757	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-10				TAGAGGATTTGCCATTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.343509821905816					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479196	44479246	46899233	46899283	17758	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-11				CACAAAAAGTGAAGAAGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44813422426687938					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479445	44479495	46899482	46899532	17759	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-12				TGCTATTTGAGACAGGGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72417749707795109					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479584	44479634	46899621	46899671	17760	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-13				ATTAAAAAGATTAGCAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2051603343067438					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479468	44479518	46899505	46899555	17761	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-14				CTCAGCTGCCCAGAGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33874610508652642					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479550	44479600	46899587	46899637	17762	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-15				TGTAGTCCCAGTTATGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.053079639347711483					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479518	44479568	46899555	46899605	17763	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-16				GAAGATCACTTGAGCTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3603655178348032					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479318	44479368	46899355	46899405	17764	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-2				GCATTTGCTATGGAATGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.182278544890371					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479224	44479274	46899261	46899311	17765	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-3				GAGGCCTTTCCCCTTTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.974449800468394					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479276	44479326	46899313	46899363	17766	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-4				AGCAGGAGGAAAGCACTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39041323628503483					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479262	44479312	46899299	46899349	17767	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-5				GAATAAGTAACTGAAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82622469174809221					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479365	44479415	46899402	46899452	17768	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-6				TCACTTTCATTGAGTGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48404401045369683					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479302	44479352	46899339	46899389	17769	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-7				GCCTTGGAATGCTTTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.160732771768238					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479347	44479397	46899384	46899434	17770	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-8				TTAGGCCTGCCTTTGTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.282958564384617					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-77901	chr18	44479243	44479293	46899280	46899330	17771	hg38	N/A	enh69458	N/A	Enhatls83574	enhancer	SMAD2e-8-9				ATTCAGTTACTATTTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41654818520322812					PIAS2	chr18	46803217	46920148	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1919
enhrx-lit453	chr18	44241026	44241076	46661063	46661113	17772	hg38					enhancer	SMAD2e-9-1				GTGGTGCACGCTGTACATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32508688226527288													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit454	chr18	44241257	44241307	46661294	46661344	17773	hg38					enhancer	SMAD2e-9-10				GCTCTTCTCAAACTTTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.053508821018824371													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit455	chr18	44241298	44241348	46661335	46661385	17774	hg38					enhancer	SMAD2e-9-11				TTCATAGACATTTGTTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1974183685271019													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit456	chr18	44241271	44241321	46661308	46661358	17775	hg38					enhancer	SMAD2e-9-12				TTAGAAGGGGATTCAGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71148364346496029													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit457	chr18	44241178	44241228	46661215	46661265	17776	hg38					enhancer	SMAD2e-9-13				TCATGTGCCCACAGCCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.032775063769686322													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit458	chr18	44241079	44241129	46661116	46661166	17777	hg38					enhancer	SMAD2e-9-14				GCACAAACAGGCAGCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38039479438221557													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit459	chr18	44241110	44241160	46661147	46661197	17778	hg38					enhancer	SMAD2e-9-15				GAAGGCAGCAGAGTCCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05947235509207547													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit460	chr18	44241190	44241240	46661227	46661277	17779	hg38					enhancer	SMAD2e-9-16				AGCCTTGCTGGAAAGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31375995394579048													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit461	chr18	44241206	44241256	46661243	46661293	17780	hg38					enhancer	SMAD2e-9-17				AGGCTGGGAAAGAGAGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38310869362621741													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit462	chr18	44240994	44241044	46661031	46661081	17781	hg38					enhancer	SMAD2e-9-2				GGTGGAAGTCGGGTCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.648450365040326													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit463	chr18	44241096	44241146	46661133	46661183	17782	hg38					enhancer	SMAD2e-9-3				TTGTGCCGCCCTCACCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11852951373369321													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit464	chr18	44240970	44241020	46661007	46661057	17783	hg38					enhancer	SMAD2e-9-4				AATGATGCCTAGAATCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96405721088768614													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit465	chr18	44241150	44241200	46661187	46661237	17784	hg38					enhancer	SMAD2e-9-5				GCTCAGCCAATCAGATGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0827077255549554													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit466	chr18	44241041	44241091	46661078	46661128	17785	hg38					enhancer	SMAD2e-9-6				TGCACCACAAGCTTCAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32702829812189532													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit467	chr18	44241131	44241181	46661168	46661218	17786	hg38					enhancer	SMAD2e-9-7				TCTGCCATTCAGTCTGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1204864822050269													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit468	chr18	44241008	44241058	46661045	46661095	17787	hg38					enhancer	SMAD2e-9-8				ACTTCCACCAATGCTGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15468326433830559													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit469	chr18	44241234	44241284	46661271	46661321	17788	hg38					enhancer	SMAD2e-9-9				ACAGTTCCCAGCATAGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1095044116821943													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77942	chr18	45494441	45494491	47968070	47968120	17789	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-1				GGCTGTATCACTAGGCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62310396744831231					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494617	45494667	47968246	47968296	17790	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-10				GAGGTAATCTCTAAACTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7958647057532791					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494486	45494536	47968115	47968165	17791	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-11				GTCTCTAGCCCCTCCAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9527146865194118					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494366	45494416	47967995	47968045	17792	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-12				ATGTTTGACAATATACACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22844875746912471					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494754	45494804	47968383	47968433	17793	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-13				AGGAAAAAGATGTCAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80628836405474014					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494778	45494828	47968407	47968457	17794	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-14				TCTGATCCAAAAGAAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38705907775489079					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494312	45494362	47967941	47967991	17795	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-15				TTCTGGTTGTCTCCTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49776473573879793					SMAD2	chr18	47808956	47931146	34949				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494312	45494362	47967941	47967991	17796	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-15				TTCTGGTTGTCTCCTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49776473573879793					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494499	45494549	47968128	47968178	17797	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-16				CATGGTATCAGCTCCACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082605424992366616					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494394	45494444	47968023	47968073	17798	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-17				GCTTGAGTGAGCTTCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0352142946243709					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494554	45494604	47968183	47968233	17799	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-18				AGACTATCTGGAGTGACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46845743981820492					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494640	45494690	47968269	47968319	17800	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-19				TCCTCTGTGTGCTGGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14047978452912491					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494456	45494506	47968085	47968135	17801	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-2				CGTGACATGCGTATTCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14282767920374151					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494571	45494621	47968200	47968250	17802	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-20				TTTTGTTTCTCTGAGTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056126798458621868					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494526	45494576	47968155	47968205	17803	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-21				TGTGATTTAGGGTGGGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39338022231603642					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494585	45494635	47968214	47968264	17804	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-22				GAAACAAAAACATTCCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.359057447794189					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494716	45494766	47968345	47968395	17805	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-23				TACAGATTTAGAAATGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0012223777555270829					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494716	45494766	47968345	47968395	17806	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-23				TACAGATTTAGAAATGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0012223777555270829					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494599	45494649	47968228	47968278	17807	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-24				CTTGGAATGTCATGCCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54974808264899988					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494542	45494592	47968171	47968221	17808	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-25				AATCACATTGTTAGACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.672668888539514					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494420	45494470	47968049	47968099	17809	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-26				AGTGTTCAGAGCTTTTATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18715923314414071					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494328	45494378	47967957	47968007	17810	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-3				CGCACTCTACCTAATTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35257824336459409					SMAD2	chr18	47808956	47931146	34949				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494328	45494378	47967957	47968007	17811	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-3				CGCACTCTACCTAATTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35257824336459409					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494701	45494751	47968330	47968380	17812	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-4				GCAAATGGAAGCGTACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5410279131788158					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494701	45494751	47968330	47968380	17813	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-4				GCAAATGGAAGCGTACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5410279131788158					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494793	45494843	47968422	47968472	17814	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-5				GGATCAGATTTCTTCGTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45506666026050607					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494379	45494429	47968008	47968058	17815	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-6				TACACAAAGGATTTCCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33762705303457491					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494653	45494703	47968282	47968332	17816	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-7				ACACAGAGGAGACCTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068559106980574908					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494665	45494715	47968294	47968344	17817	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-8				AATGTAACCCTGCCCAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5381427653620996					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494734	45494784	47968363	47968413	17818	hg38	N/A	enh4831	fant55051	Enhatls83616	enhancer	SMAD2e+1-9				CTGTACCTGCTTTGAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14934472227895579					SMAD2	chr18	47808956	47931146	36832				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45494734	45494784	47968363	47968413	17819	hg38	N/A	enh4831	N/A	Enhatls83616	enhancer	SMAD2e+1-9				CTGTACCTGCTTTGAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14934472227895579					SMAD2	chr18	47808956	47931146	37220				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77948	chr18	46131910	46131960	48605539	48605589	17820	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-1				TGCTGCTACCATGCTCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29668296500483438					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132086	46132136	48605715	48605765	17821	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-10				GACCTAAGAGCTCCTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28759015608247618					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132141	46132191	48605770	48605820	17822	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-11				AAGCCGGAAGGGAGGACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33822994494856479					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132071	46132121	48605700	48605750	17823	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-12				GCTGTCCCAGACTAGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047348770590099343					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132030	46132080	48605659	48605709	17824	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-13				GCAAGGCATCTGGCTGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0043666211276649032					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131690	46131740	48605319	48605369	17825	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-14				CTTCTAAGCTTCTAGGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14218760854038751					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131967	46132017	48605596	48605646	17826	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-15				AATTAGTCCATCAGAGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60174353419365756					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131776	46131826	48605405	48605455	17827	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-16				CTGCAAACTACACTGAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.194788939674258					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131734	46131784	48605363	48605413	17828	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-17				GGCTATGGGAGGCTCCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21773893803973829					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132011	46132061	48605640	48605690	17829	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-18				TTGCAGCAGAGAGCCCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13706533919038291					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131748	46131798	48605377	48605427	17830	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-19				GAGGGGATATAAGGCCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26116386085440818					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131855	46131905	48605484	48605534	17831	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-2				CTGTAGCCAGATACAACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20509882481086891					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132103	46132153	48605732	48605782	17832	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-20				TAGGTCACAGAGGCCCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1574169494500968					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131998	46132048	48605627	48605677	17833	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-21				CATCAGGAGCTGCCCCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.025700156769206919					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131884	46131934	48605513	48605563	17834	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-22				AACCTCTTCACACACACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37206195082092069					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132188	46132238	48605817	48605867	17835	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-23				GGTCCTGGAAATACAATGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38551488350173507					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132173	46132223	48605802	48605852	17836	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-24				GCCCACTTCATACCAGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16648401164849561					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132048	46132098	48605677	48605727	17837	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-25				TGCAGTGAGGAAGGACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56795224364562658					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132201	46132251	48605830	48605880	17838	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-26				CAATGATGGGAAAAACGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3779885367987561					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131942	46131992	48605571	48605621	17839	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-27				TCTACTTCCCATTATTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47940418311950578					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131765	46131815	48605394	48605444	17840	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-28				ACTGAGACATGGAGAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5069845805213229					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132233	46132283	48605862	48605912	17841	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-3				TCAAGCACGCACACTAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.227484359011339					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131982	46132032	48605611	48605661	17842	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-4				GACTAATTAGAACAGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1066995101917846					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131720	46131770	48605349	48605399	17843	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-5				CCAGTGACAGTTGAGGCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33531729500999441					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131832	46131882	48605461	48605511	17844	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-6				GAGCAGGCTGAGTGGTTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1020202034593362					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132153	46132203	48605782	48605832	17845	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-7				GGCAATCAACAGAAGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050344644150683307					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46132117	46132167	48605746	48605796	17846	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-8				TCCCTCCGAGAGGCCCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6286071386478791					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77948	chr18	46131788	46131838	48605417	48605467	17847	hg38	N/A	enh32663	N/A	Enhatls83622	enhancer	SMAD2e+10-9				GTAGTTTGCAGATGGCTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.002072196646647487					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1966
enhrx-77953	chr18	46329160	46329210	48802789	48802839	17848	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-1				GGACGTTAGTACCACTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22444488767763771					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329218	46329268	48802847	48802897	17849	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-10				GGAATTCCTGCTTGTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14700254562054341					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329460	46329510	48803089	48803139	17850	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-11				CGCCTCCCTGTCCCCTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.200858140974331					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329294	46329344	48802923	48802973	17851	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-12				AAAACTTCCAGCCTCTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048249280620042467					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329184	46329234	48802813	48802863	17852	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-13				TGTCACTGGACTCAGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.022848385679149121					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329305	46329355	48802934	48802984	17853	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-14				CCTCTTCTGAGGGCTTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034278065631044539					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329528	46329578	48803157	48803207	17854	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-15				ATGCTGGGTGCTCACAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.053953665922889277					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329321	46329371	48802950	48803000	17855	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-16				TTCAAGGCCACAGCCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0067774205434406147					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329271	46329321	48802900	48802950	17856	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-17				CTCTCTCTGCTCAGGCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01305677084461775					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329334	46329384	48802963	48803013	17857	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-18				AAGGGAGCCAGCACCTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52622586741255883					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329415	46329465	48803044	48803094	17858	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-19				CAGAGAGAAGCTGAGAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19059079303188081					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329358	46329408	48802987	48803037	17859	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-2				AGGCGCGAAGCCTTATTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47154724185226271					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329444	46329494	48803073	48803123	17860	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-20				GGAGGCGGGGGGATGGCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45774930588912338					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329471	46329521	48803100	48803150	17861	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-3				GCTCTGCTGATCCGTAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28907830135861268					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329378	46329428	48803007	48803057	17862	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-4				ATTCTGTCTCACACTTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12063480064668421					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329198	46329248	48802827	48802877	17863	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-5				TCCTCAAAGCAAGGTGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010439963596888809					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329517	46329567	48803146	48803196	17864	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-6				AGCACCCAGCATATTTCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58341256597736879					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329233	46329283	48802862	48802912	17865	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-7				GACAGATGAAGAATACCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.160158446866787					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329502	46329552	48803131	48803181	17866	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-8				TCTATTGGCAAAATCAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53115267242959907					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46329402	46329452	48803031	48803081	17867	hg38	N/A	enh4835	N/A	Enhatls83630	enhancer	SMAD2e+11-9				AGAAGTCAGGCTGATCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39627222582450211					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340602	46340652	48814231	48814281	17868	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-1				TGCTAACTCGGGTGTTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2534284608500661					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340382	46340432	48814011	48814061	17869	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-10				ACCCCCTGTCTTTGGTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3019380885956473					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340291	46340341	48813920	48813970	17870	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-11				AGCCCTGTGCCTGTGTATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29832381122754142					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340461	46340511	48814090	48814140	17871	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-12				AGCAGACTCCTCCCAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2662267589881771					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340500	46340550	48814129	48814179	17872	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-13				GTCCCACAGCAACACTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33663497864659653					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340564	46340614	48814193	48814243	17873	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-14				TATAAGGAAATGACAAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.317832406888896					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340527	46340577	48814156	48814206	17874	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-15				TTCTTTGATGTGTGCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24263568440374089					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340656	46340706	48814285	48814335	17875	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-16				CTGATTCTAACGTGCAACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10667338455704289					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340613	46340663	48814242	48814292	17876	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-2				CCCGAGTTAGCACTTGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7610957632818629					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340418	46340468	48814047	48814097	17877	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-3				GTGCTGTCACCAACAAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40831467657442583					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340576	46340626	48814205	48814255	17878	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-4				ACAAGCTGGGGGTTGATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.375854615455994					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340449	46340499	48814078	48814128	17879	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-5				ATGATGTCACCTCCTGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2403308735512566					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340338	46340388	48813967	48814017	17880	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-6				TACCAGCCAGAGACAGATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35924668694022871					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340538	46340588	48814167	48814217	17881	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-7				GTGCCTTCATGGGTATTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20358216283986069					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340636	46340686	48814265	48814315	17882	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-8				TGGCTCTGAACCACAACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.015492683826421791					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77953	chr18	46340407	46340457	48814036	48814086	17883	hg38	N/A	enh4835	fant55083	Enhatls83630	enhancer	SMAD2e+12-9				AACAAATTCTGGTTGCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14298257779351339					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1971
enhrx-77954	chr18	46368003	46368053	48841632	48841682	17884	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-1				CTTTGCTCGATTCAAGACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23048922944096251					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368230	46368280	48841859	48841909	17885	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-10				CGTTGGAGCTCAGCCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035363276117913477					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368284	46368334	48841913	48841963	17886	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-11				TCTTTTGTGTGTGAGCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1842541133335					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368093	46368143	48841722	48841772	17887	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-12				GGAGACAGTGAGCGCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.703614874779643					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368016	46368066	48841645	48841695	17888	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-13				AAGACGCTGGCTCGGGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35993702524779952					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368271	46368321	48841900	48841950	17889	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-14				AGCGCTGAGGAGTCCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12994784654588681					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368215	46368265	48841844	48841894	17890	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-15				GATTCCAGACTGTTTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034936680229997512					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368082	46368132	48841711	48841761	17891	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-16				GCGCTTCCCAGGCACCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48622822017930772					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368177	46368227	48841806	48841856	17892	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-17				CCATCTCGGGTGGGAGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3018513041567209					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368257	46368307	48841886	48841936	17893	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-18				TATCTCCTTTCCTGCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49716015515750628					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368345	46368395	48841974	48842024	17894	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-19				GGTGGAGGAGGCTTTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56525815933587065					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368361	46368411	48841990	48842040	17895	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-2				GGTAGATTTAATGAAACCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.301083781394938					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368071	46368121	48841700	48841750	17896	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-20				GCACCGGGCTGGTGGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18221529034382389					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368193	46368243	48841822	48841872	17897	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-21				GGCAGGGTGGCTCTCAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3256795302750583					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368034	46368084	48841663	48841713	17898	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-22				CGCCTGCCTGCCCACCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19136888296974419					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368048	46368098	48841677	48841727	17899	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-23				AGGCAGGCGGGCAGGCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1316449271385132					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368382	46368432	48842011	48842061	17900	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-3				ACTGCCCCCGATTGAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078223126745760874					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368127	46368177	48841756	48841806	17901	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-4				TATCCCAGGGGTCCCGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7380150480234241					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368164	46368214	48841793	48841843	17902	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-5				CGGCTATCAGTGGCCATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.085077582383650874					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368113	46368163	48841742	48841792	17903	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-6				TCCTCAGCCGGTGTTATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30991409701716682					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368144	46368194	48841773	48841823	17904	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-7				ACCTGGCTGATAAGGCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055913547496626421					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368312	46368362	48841941	48841991	17905	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-8				TAGGGGCTGTGCGTCTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5500020895857507					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77954	chr18	46368330	46368380	48841959	48842009	17906	hg38	N/A	enh17679	N/A	Enhatls83631	enhancer	SMAD2e+13-9				CCCTACCTACTGGAAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52766270860746256					CTIF	chr18	48539030	48863217	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1972
enhrx-77958	chr18	46524763	46524813	48998393	48998443	17907	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-1				GCCAGTTCTTGACTAAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035122634452804231					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524884	46524934	48998514	48998564	17908	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-10				GATGGAAGGGTGTCCCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69483702070901865					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524884	46524934	48998514	48998564	17909	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-10				GATGGAAGGGTGTCCCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69483702070901865					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524356	46524406	48997986	48998036	17910	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-11				CTATAGGATAGATGGTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.557131525311012					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524540	46524590	48998170	48998220	17911	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-12				ATAGCTTGGTCCTGTTTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05755416168573077					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524256	46524306	48997886	48997936	17912	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-13				CAAGCCTGTGACAGTCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22420188142266631					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524454	46524504	48998084	48998134	17913	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-14				GGCTATTTCTGTGAGGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20234426264934979					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524719	46524769	48998349	48998399	17914	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-15				CGTGACTGCCTTGGAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.179367521027873					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524933	46524983	48998563	48998613	17915	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-16				GTGGTTCCAGCATGGAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1912484840381225					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524683	46524733	48998313	48998363	17916	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-17				ATGTAACACCCCTGGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.304608802040807					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524842	46524892	48998472	48998522	17917	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-18				TCAGTGGGAGGTCTGGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074687243984897789					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524482	46524532	48998112	48998162	17918	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-19				GACTGAGTCAAAAGTAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.232777757357298					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524422	46524472	48998052	48998102	17919	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-2				CCAGAGTGCTTGGTGACGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19611626260321671					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524795	46524845	48998425	48998475	17920	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-20				GAGCTGCGCTCACCAGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58668839103259707					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524737	46524787	48998367	48998417	17921	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-21				CAGGCACCAAGGGTCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28579453715934527					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524872	46524922	48998502	48998552	17922	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-22				TCCCCACGGGGCTCAGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.098836519647493223					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524872	46524922	48998502	48998552	17923	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-22				TCCCCACGGGGCTCAGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.098836519647493223					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524372	46524422	48998002	48998052	17924	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-23				GAATGAGTGTGAATTCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54082087845513149					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524952	46525002	48998582	48998632	17925	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-24				ATATTTTAAAGCACCCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14767336677635809					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524513	46524563	48998143	48998193	17926	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-25				GGGGAAGAAGATCAAATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30361324902124981					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524398	46524448	48998028	48998078	17927	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-26				CAGCAGACACATTTAATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57504849065472474					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524568	46524618	48998198	48998248	17928	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-27				CTGAGAGGGGACGTGGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039322406872768112					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46525025	46525075	48998655	48998705	17929	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-28				GACGCTGGGCAGGAGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50531220084614037					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524553	46524603	48998183	48998233	17930	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-29				GTTTATGGGGCTGCTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45015124622827152					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524296	46524346	48997926	48997976	17931	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-3				GATGGGCGCGGGAGACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11746261714051109					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524902	46524952	48998532	48998582	17932	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-30				CACTGCTCTAGAGAATGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22167226523416431					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524902	46524952	48998532	48998582	17933	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-30				CACTGCTCTAGAGAATGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22167226523416431					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524625	46524675	48998255	48998305	17934	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-31				CTTGCTTTTCTGTGGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1485042496453976					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524526	46524576	48998156	48998206	17935	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-32				CTTCTTCCCCTAAAATAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0198752878584075					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46525012	46525062	48998642	48998692	17936	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-33				AGTCCCTTGGCTCTCAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12782631571598571					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524701	46524751	48998331	48998381	17937	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-34				TCACGCATTCCCCACCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020807409230349821					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524610	46524660	48998240	48998290	17938	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-35				AAAGCAAGCACCCAGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30788056181747159					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46525047	46525097	48998677	48998727	17939	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-36				CTCAGCAGCTGGTCAGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8340276704366048					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524806	46524856	48998436	48998486	17940	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-37				ACCAGCCTTGGGGTGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.043547667022743					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524748	46524798	48998378	48998428	17941	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-38				GAACTGGCAGGCAGGCACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97212445233163713					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524599	46524649	48998229	48998279	17942	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-39				CACAGCTTCCTCCCTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18804552132943891					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524975	46525025	48998605	48998655	17943	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-4				CTCACGGTTACATCAGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.181250264209781					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524819	46524869	48998449	48998499	17944	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-40				TGGAGGCTGGGAGGGTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4522814202761789					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524307	46524357	48997937	48997987	17945	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-41				GGCCAGGGCAGGATGGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.256074101630424					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524991	46525041	48998621	48998671	17946	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-42				GGCTGCACACTAGAATCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.075750682382724213					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524916	46524966	48998546	48998596	17947	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-43				AGAGCAGTGGTTCTCAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3565537608230922					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524916	46524966	48998546	48998596	17948	hg38	N/A	enh17686	N/A	Enhatls83638	enhancer	SMAD2e+14-43				AGAGCAGTGGTTCTCAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3565537608230922					DYM	chr18	49036386	49461347	35362				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524338	46524388	48997968	48998018	17949	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-5				GGCCGTGACACTGTGTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1501476459344365					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524322	46524372	48997952	48998002	17950	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-6				CACGGCCAAAACATGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20031100785051451					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524648	46524698	48998278	48998328	17951	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-7				AGAGACATCCGTAGTGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.232566572628653					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524672	46524722	48998302	48998352	17952	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-8				GGGGTGTTACATCATGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3265781552858149					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-77958	chr18	46524857	46524907	48998487	48998537	17953	hg38	N/A	enh17686	fant55118	Enhatls83638	enhancer	SMAD2e+14-9				GGACTGGGCCTGTTGTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28776901034990848					DYM	chr18	49036386	49461347	37836				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1976
enhrx-lit470	chr18	47013600	47013650	49487230	49487280	17954	hg38					enhancer	SMAD2e+15-1				ACAATGTCCGCACTTCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44297076177924311													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit471	chr18	47013880	47013930	49487510	49487560	17955	hg38					enhancer	SMAD2e+15-10				CAAACGGCGCGGCACCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14436802299118													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit472	chr18	47013524	47013574	49487154	49487204	17956	hg38					enhancer	SMAD2e+15-11				GGGCTTTGTAGCTGCTCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12507436021228													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit473	chr18	47013704	47013754	49487334	49487384	17957	hg38					enhancer	SMAD2e+15-12				CACGCAGCAGTGTTGCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30712385118720281													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit474	chr18	47013904	47013954	49487534	49487584	17958	hg38					enhancer	SMAD2e+15-13				AGGTGGCAGCTAGGCCGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33237904195124979													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit475	chr18	47013640	47013690	49487270	49487320	17959	hg38					enhancer	SMAD2e+15-14				GAGCCAATGGGCGCCTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.02806723444411													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit476	chr18	47013995	47014045	49487625	49487675	17960	hg38					enhancer	SMAD2e+15-15				GCAACTGACGTTTGTAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1097346173479942													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit477	chr18	47013615	47013665	49487245	49487295	17961	hg38					enhancer	SMAD2e+15-16				CTGCGGATCGTCCCTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19057729491402081													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit478	chr18	47013719	47013769	49487349	49487399	17962	hg38					enhancer	SMAD2e+15-17				GAAGCCTCGCCGCGCCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39421336849059518													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit479	chr18	47013387	47013437	49487017	49487067	17963	hg38					enhancer	SMAD2e+15-18				GGAGCGCGCTCGCGGAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4849205683711364													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit480	chr18	47013475	47013525	49487105	49487155	17964	hg38					enhancer	SMAD2e+15-19				CAGGAGGCCGCGCACCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.029077633224058541													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit481	chr18	47013628	47013678	49487258	49487308	17965	hg38					enhancer	SMAD2e+15-2				CGATCCGCAGCCGAGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2050476334265901													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit482	chr18	47013730	47013780	49487360	49487410	17966	hg38					enhancer	SMAD2e+15-20				CGGCGAGGCTTCCGGCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00051452569750884837													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit483	chr18	47013773	47013823	49487403	49487453	17967	hg38					enhancer	SMAD2e+15-21				GTTGGGCATCTGGGACGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35013136218891688													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit484	chr18	47013972	47014022	49487602	49487652	17968	hg38					enhancer	SMAD2e+15-22				GGCAGAGCAAACTAACATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063162719837173142													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit485	chr18	47013869	47013919	49487499	49487549	17969	hg38					enhancer	SMAD2e+15-23				TGATGCCTGTGCAAACGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36897990520653251													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit486	chr18	47013934	47013984	49487564	49487614	17970	hg38					enhancer	SMAD2e+15-24				GGATAAGCTATTAGTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20258142939061019													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit487	chr18	47013563	47013613	49487193	49487243	17971	hg38					enhancer	SMAD2e+15-25				CGGTCGCGGGTGAGTGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21804926759157831													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit488	chr18	47013413	47013463	49487043	49487093	17972	hg38					enhancer	SMAD2e+15-26				CGGTGCCTGCCTTCGCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33008486473143689													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit489	chr18	47013549	47013599	49487179	49487229	17973	hg38					enhancer	SMAD2e+15-27				TGTGCCCGGGCTAGCGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067192241432986036													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit490	chr18	47013918	47013968	49487548	49487598	17974	hg38					enhancer	SMAD2e+15-28				CTTATCCACAGTTGCCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31375995394578882													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit491	chr18	47013446	47013496	49487076	49487126	17975	hg38					enhancer	SMAD2e+15-29				CGGGCCGCGACCGCCGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4354755734252822													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit492	chr18	47013576	47013626	49487206	49487256	17976	hg38					enhancer	SMAD2e+15-3				AGCTGCGTTTCCGCGGTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.037633721522755931													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit493	chr18	47013433	47013483	49487063	49487113	17977	hg38					enhancer	SMAD2e+15-30				TCGCGGCCCGCCGGCCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44942538811977711													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit494	chr18	47013821	47013871	49487451	49487501	17978	hg38					enhancer	SMAD2e+15-31				GGTCTGGGTGTAGTCAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41651445600624659													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit495	chr18	47013690	47013740	49487320	49487370	17979	hg38					enhancer	SMAD2e+15-32				TGCTGCGTGCTGTGCGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1456601013582407													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit496	chr18	47013501	47013551	49487131	49487181	17980	hg38					enhancer	SMAD2e+15-33				CTGCGAGCGCGGCCCGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38641820326831039													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit497	chr18	47013741	47013791	49487371	49487421	17981	hg38					enhancer	SMAD2e+15-34				CTACCTGCAGGCCGCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02833073790319128													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit498	chr18	47013950	47014000	49487580	49487630	17982	hg38					enhancer	SMAD2e+15-35				TTGCTGGTTTCTTAAATTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3249955169917188													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit499	chr18	47013513	47013563	49487143	49487193	17983	hg38					enhancer	SMAD2e+15-36				CTGCTCCGCAGGCCCAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1020170459433265													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit500	chr18	47013459	47013509	49487089	49487139	17984	hg38					enhancer	SMAD2e+15-37				CCGAGGAGGGAGGAGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040072640153941262													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit501	chr18	47013366	47013416	49486996	49487046	17985	hg38					enhancer	SMAD2e+15-38				GAGGGCGGGGCGGAGGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.920327979127564													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit502	chr18	47013671	47013721	49487301	49487351	17986	hg38					enhancer	SMAD2e+15-4				AAGGCGCGCTTGCGTCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068614909431402915													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit503	chr18	47013842	47013892	49487472	49487522	17987	hg38					enhancer	SMAD2e+15-5				TTACCGAGATCCTGCGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.160187353196131													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit504	chr18	47013652	47013702	49487282	49487332	17988	hg38					enhancer	SMAD2e+15-6				GCCTTCAACGGGGACGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57641553743720708													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit505	chr18	47013490	47013540	49487120	49487170	17989	hg38					enhancer	SMAD2e+15-7				CGCCTAGGACTCTGCGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48261875291262729													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit506	chr18	47013753	47013803	49487383	49487433	17990	hg38					enhancer	SMAD2e+15-8				AGGACTTTCGCGCTACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16295747547682821													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit507	chr18	47013791	47013841	49487421	49487471	17991	hg38					enhancer	SMAD2e+15-9				CCAACTAAAAGCTTCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33559196166486138													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-77988	chr18	47190709	47190759	49664339	49664389	17992	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-1				GTTTCGGTGGAAGAACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32262224279089752					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190650	47190700	49664280	49664330	17993	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-10				GGAGCAGAAGCATTCAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41698293793285462					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190614	47190664	49664244	49664294	17994	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-11				TGAGGCCTGGGCCCCTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.478111105722137					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190458	47190508	49664088	49664138	17995	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-12				CACTGTGAGTGGCTGGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16295861677553641					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190627	47190677	49664257	49664307	17996	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-13				CTTCTCCCCTGACTGAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05429136416065198					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190698	47190748	49664328	49664378	17997	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-14				AGAACTTCCAGGACAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18258327609239219					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190469	47190519	49664099	49664149	17998	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-15				GAGCTGAGCAGCACTGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01756220398534233					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190494	47190544	49664124	49664174	17999	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-16				CTCAGCTCCGCCCCTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.542334122399424					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190668	47190718	49664298	49664348	18000	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-17				GGGAGCTGGCTGCTTCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.369803652771259					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190541	47190591	49664171	49664221	18001	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-18				TAGAGCAGGTGGAATGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092902920772037226					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190588	47190638	49664218	49664268	18002	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-19				ACAGCCCTGGAGACAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47965426554183621					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190506	47190556	49664136	49664186	18003	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-2				CCTTGCCCCGGATGCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035348808503287053					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190439	47190489	49664069	49664119	18004	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-20				TAGGAAATGGGAGGAAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25430247829267127					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190682	47190732	49664312	49664362	18005	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-21				GGGCAGGTGTTGTGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1068416007591991					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190333	47190383	49663963	49664013	18006	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-3				ACAGTTTAACTGGTGAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13562398907168119					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190572	47190622	49664202	49664252	18007	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-4				GGGCTGTGTAAAATGCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1304576838617168					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190373	47190423	49664003	49664053	18008	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-5				TGTATTGCAGTATCATGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1101151422676262					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190420	47190470	49664050	49664100	18009	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-6				GTGGGGCGGGGGCACTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5285972277425498					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190345	47190395	49663975	49664025	18010	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-7				GTGAGTCAGGGATTTATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.069230944796815547					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190602	47190652	49664232	49664282	18011	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-8				AGCCTGGGGACTCCATCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22060694426207819					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47190555	47190605	49664185	49664235	18012	hg38	N/A	enh17693	N/A	Enhatls83668	enhancer	SMAD2e+16-9				GGTTGGAGTAGAAGTAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1149194982404958					LIPG	chr18	49560698	49599185	62891				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252785	47252835	49726415	49726465	18013	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-1				GGAACGCATTTCTACCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17894006837896781					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252603	47252653	49726233	49726283	18014	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-10				ATCAGCCTTTCATGTTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17119672373777289					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252603	47252653	49726233	49726283	18015	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-10				ATCAGCCTTTCATGTTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17119672373777289					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252586	47252636	49726216	49726266	18016	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-11				GCTGATAGATTATTACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2979327401223428					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252586	47252636	49726216	49726266	18017	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-11				GCTGATAGATTATTACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2979327401223428					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252704	47252754	49726334	49726384	18018	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-12				CAGGACTAGCTTTCTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3459850508293017					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252414	47252464	49726044	49726094	18019	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-13				AGAGCTCTTTGACTTGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02583177114138167					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252368	47252418	49725998	49726048	18020	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-14				ATCAAGGGTGTTAATCTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.784577647014921					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252328	47252378	49725958	49726008	18021	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-15				CAAATGGGGCCAGATGGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0635330606144354					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252342	47252392	49725972	49726022	18022	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-16				TCACTTCAGTACAGCAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18935833585844941					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252383	47252433	49726013	49726063	18023	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-17				CATCTCTCTTCCCTTATCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.606950619601709					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252643	47252693	49726273	49726323	18024	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-18				TGTGACTCACCCTCTGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15881067907715221					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252536	47252586	49726166	49726216	18025	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-19				CACCTCCACTTCCTTATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34971071858753722					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252854	47252904	49726484	49726534	18026	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-2				TCGAAACTGTCTGTGAAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.177131150622943					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252264	47252314	49725894	49725944	18027	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-20				GGGCCCTTGGAAACTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.061401313254261361					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252733	47252783	49726363	49726413	18028	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-21				TTGGAGGGGAGCAGACCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26125883162020741					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252432	47252482	49726062	49726112	18029	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-22				GAGACAGAAGTGTATTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5827933955827278					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252621	47252671	49726251	49726301	18030	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-23				GCTTCTCAAGCAGATTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30996765612492189					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252621	47252671	49726251	49726301	18031	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-23				GCTTCTCAAGCAGATTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30996765612492189					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252877	47252927	49726507	49726557	18032	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-24				AAGAAAGTCCTGACTAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1405468347017399					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252917	47252967	49726547	49726597	18033	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-25				AGATTTTGTTGGCTGTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2735171554899074					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252478	47252528	49726108	49726158	18034	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-26				TAGCTGAGCTGCCAGGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.30267224582018					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252554	47252604	49726184	49726234	18035	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-27				TTAGGAATTTTAACAAAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1044633453187952					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252444	47252494	49726074	49726124	18036	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-28				ACTTCTGTCTCTTGCCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40902405313081658					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252928	47252978	49726558	49726608	18037	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-29				CACTCATACACAGATTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.199015315366053					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252748	47252798	49726378	49726428	18038	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-3				AGGCAATCGCTGCGGCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084975477302837915					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252489	47252539	49726119	49726169	18039	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-30				ACAGCCCGACCCCCACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0119192944201021					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252309	47252359	49725939	49725989	18040	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-31				GAGGGGAGGAAATGACCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43267813097139168					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252829	47252879	49726459	49726509	18041	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-32				AGCCACACACACTGCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3765707503385462					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252829	47252879	49726459	49726509	18042	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-32				AGCCACACACACTGCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3765707503385462					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252524	47252574	49726154	49726204	18043	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-33				AAGTGGAGGTGGGGGACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33739332259109978					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252799	47252849	49726429	49726479	18044	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-34				CAGAAGCTGGGAGGCCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.137934260438588					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252799	47252849	49726429	49726479	18045	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-34				CAGAAGCTGGGAGGCCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.137934260438588					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252815	47252865	49726445	49726495	18046	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-35				GCTTCTGCTCAGCTCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33360693650708961					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252815	47252865	49726445	49726495	18047	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-35				GCTTCTGCTCAGCTCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33360693650708961					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252900	47252950	49726530	49726580	18048	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-36				AAAATAAGAAAGACAGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53937367496767474					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252688	47252738	49726318	49726368	18049	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-37				GGGAGGATCTCCTGATCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38499750045668968					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252719	47252769	49726349	49726399	18050	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-4				TAGTCCTGCTCCTATTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40414749194007971					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252768	47252818	49726398	49726448	18051	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-5				CGTTCCAGCGTCACCGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25224512967543328					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252285	47252335	49725915	49725965	18052	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-6				GTCTTGCCTATAAACCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0680634169776218					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252947	47252997	49726577	49726627	18053	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-7				AGTGTCTGCCCCGTAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39462658322017669					ACAA2	chr18	49782163	49813953	46545				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252668	47252718	49726298	49726348	18054	hg38	N/A	enh17694	fant55138	Enhatls83668	enhancer	SMAD2e+17-8				GGTCCAGCCTTGCATTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093409597505471245					ACAA2	chr18	49782163	49813953	55695				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47252462	47252512	49726092	49726142	18055	hg38	N/A	enh17694	N/A	Enhatls83668	enhancer	SMAD2e+17-9				TCAGCTATTGCTGGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37506654565121189					ACAA2	chr18	49782163	49813953	55904				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286504	47286554	49760134	49760184	18056	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-1				ATAAGGAACCCGAAACCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31352640578723379					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286452	47286502	49760082	49760132	18057	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-10				AAAGCCTACCTCCACCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40777072740763792					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286419	47286469	49760049	49760099	18058	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-11				GGGACGTGTTGGGGTCGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27381382198774651					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286071	47286121	49759701	49759751	18059	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-12				GCCCAACATCCAGCTTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19568663832225619					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286613	47286663	49760243	49760293	18060	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-13				AGGAAGTGGCTTTAACTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14660717956976441					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286690	47286740	49760320	49760370	18061	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-14				TGAGCCACTGCGGAGTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38842012863440051					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286488	47286538	49760118	49760168	18062	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-15				TGGGCTATTCTCCCGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2147981752690217					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286087	47286137	49759717	49759767	18063	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-16				ATTCAGGATCAGCCTTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39894775932603438					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286181	47286231	49759811	49759861	18064	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-17				GGCCAGGGACACAGTACCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052350094824589757					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286639	47286689	49760269	49760319	18065	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-18				CAGGTGCCTCCCTGGGATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.152854724950834					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286390	47286440	49760020	49760070	18066	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-19				TGGGGTTCCTGTGCAAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059726902827584548					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286211	47286261	49759841	49759891	18067	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-2				CGGGGCCCATCAACTGCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.143249561688596					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286516	47286566	49760146	49760196	18068	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-20				GGGTTCCTTATCTGAACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19355019728256259					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286666	47286716	49760296	49760346	18069	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-21				CTCTTCCGCCGCCCCCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44644875907151449					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286408	47286458	49760038	49760088	18070	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-22				TCAGGGGGCAGGGGACGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54567985307187483					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286563	47286613	49760193	49760243	18071	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-23				CTTGGATGAAGGCCTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33884856284439152					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286579	47286629	49760209	49760259	18072	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-24				TATTCACTGAGAGCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.551814844192044					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286099	47286149	49759729	49759779	18073	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-25				GGCCTGGATTTCCCAGCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.222459718967584					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286043	47286093	49759673	49759723	18074	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-26				AGGGATGTGTTGAGAGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16293038176415639					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286468	47286518	49760098	49760148	18075	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-27				ATGCAGGAGCTCCCTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.300314142275156					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286227	47286277	49759857	49759907	18076	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-28				CGTGGGGCCACTCTGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39715539496547131					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286552	47286602	49760182	49760232	18077	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-29				CACCTGGGGAGCTTGGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60026932356187079					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286328	47286378	49759958	49760008	18078	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-3				GGAAGGCTTAAAGGGCTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41579632605031358					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286311	47286361	49759941	49759991	18079	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-30				GTGGGGGGCTGGTTAAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.132222198865199					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286360	47286410	49759990	49760040	18080	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-31				CTTCACTCTCTGCCTCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0698636486771414					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286193	47286243	49759823	49759873	18081	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-32				AGTACCGGGGGCTGGGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90967267240751459					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286371	47286421	49760001	49760051	18082	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-33				CAGAGAGTGAAGGGTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26614705178445952					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286166	47286216	49759796	49759846	18083	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-34				AGGAGCTTACAGTCTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26195758970531441					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286627	47286677	49760257	49760307	18084	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-35				GGAGGCACCTGAGGAGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.168978247154651					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286725	47286775	49760355	49760405	18085	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-36				GGGCACCGGGCTGGGCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5636655590229473					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286300	47286350	49759930	49759980	18086	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-37				GTGTGTAGGGGGTGGGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3801945661589461					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286826	47286876	49760456	49760506	18087	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-38				GAGACAGGGTTGCACCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.022822465305901381					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286803	47286853	49760433	49760483	18088	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-39				TCAGGAATTCAAGAGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13321472399069029					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286345	47286395	49759975	49760025	18089	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-4				CCGAGGATAGTCTGTCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16173811482881351					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286752	47286802	49760382	49760432	18090	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-40				TGCCTATAATCCCAACACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.439149250002077					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286288	47286338	49759918	49759968	18091	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-41				GTGTGTGTGTGTGTGTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77730782155885181					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286780	47286830	49760410	49760460	18092	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-42				CGAGGCAGGTGGATCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2269050054014432					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286763	47286813	49760393	49760443	18093	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-43				GCCTCGGTCTCCCAAAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0142665006182019					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286713	47286763	49760343	49760393	18094	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-5				GCCCGGTGCCCTAATTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.514522428529946					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286152	47286202	49759782	49759832	18095	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-6				TAAGCTCCTTACAACAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2215828407619346					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286655	47286705	49760285	49760335	18096	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-7				ATATGGGAGTCCCTCTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072346815682579266					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286537	47286587	49760167	49760217	18097	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-8				GGTGCTGATAATTAGCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38929107764544862					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-77988	chr18	47286120	47286170	49759750	49759800	18098	hg38	N/A	N/A	N/A	Enhatls83668	enhancer	SMAD2e+18-9				GACGCTCACATGCTCCGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19544996679969531					ACAA2	chr18	49782163	49813953	20089				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2006
enhrx-78017	chr18	47431715	47431765	49905345	49905395	18099	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-1				TGCTCGGGATGCATGGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40617592101396849					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431810	47431860	49905440	49905490	18100	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-10				CAAACAAGACCCTTCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2190109292746078					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431939	47431989	49905569	49905619	18101	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-11				TCAGCAAACAGGTGACACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22036815820525379					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431611	47431661	49905241	49905291	18102	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-12				CATCATCCTGGACCCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49248377224869588					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431623	47431673	49905253	49905303	18103	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-13				ACTTACCCAGTGCCTACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3370450185826932					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431664	47431714	49905294	49905344	18104	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-14				AGATTGGTCTGGGCCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22989201885258939					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431950	47432000	49905580	49905630	18105	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-15				TCAGATGCATTTCAGCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41741003451070541					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431594	47431644	49905224	49905274	18106	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-16				ATGATGGAGACACAGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28816732009348578					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431912	47431962	49905542	49905592	18107	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-17				GTGGGTCACTTTCTCCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42855670095408582					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431890	47431940	49905520	49905570	18108	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-18				GCTTTGCTGAATGATTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0263275124362289					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431485	47431535	49905115	49905165	18109	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-19				CTCTTCTACCTCACTGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1974701245390468					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431503	47431553	49905133	49905183	18110	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-2				GAAGTAGTTGAGGACTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28266460656511971					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431577	47431627	49905207	49905257	18111	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-20				TCCCCAGGCTTGGAGATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.181025392469091					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431771	47431821	49905401	49905451	18112	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-21				GCTTTATCTGGGAGGTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.067262121944897					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431873	47431923	49905503	49905553	18113	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-22				TGAAATGCTAAAAAAGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0078867179199722821					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431675	47431725	49905305	49905355	18114	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-23				AAAGGAAACAGAGATTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1157443956023675					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431562	47431612	49905192	49905242	18115	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-24				CCTGTCCTCTGTACCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.075962613298259332					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431841	47431891	49905471	49905521	18116	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-25				TCTAATTGAGCACTTGTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47383686283599868					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431758	47431808	49905388	49905438	18117	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-26				GGTGAGATGGGAAGGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.146650509447015					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431744	47431794	49905374	49905424	18118	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-27				GCAGAAAGGCAAGAGAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95863951924194934					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431702	47431752	49905332	49905382	18119	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-3				ATCCCGAGCAGAAAGGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13368167598473521					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431651	47431701	49905281	49905331	18120	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-4				CTGAATGACTAAACCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18810395255517731					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47432001	47432051	49905631	49905681	18121	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-5				TCGCCACAAAGTCTTGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045686660214696667					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431472	47431522	49905102	49905152	18122	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-6				GGTAGAAGAGTGCTCAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2003540385016731					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431527	47431577	49905157	49905207	18123	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-7				CACATGATGTAGAATGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47426334100727352					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431783	47431833	49905413	49905463	18124	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-8				AGTGTTAGACTGGCTTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3533045108997247					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-78017	chr18	47431975	47432025	49905605	49905655	18125	hg38	N/A	N/A	N/A	Enhatls83701	enhancer	SMAD2e+19-9				CCCTAGTCTAGCTCTCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1368232990183022					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2035
enhrx-77942	chr18	45533866	45533916	48007495	48007545	18126	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-1				CATCCACTAACACCTCAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070188126733724238					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534405	45534455	48008034	48008084	18127	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-10				GACCCGACTCCCGGCCGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0441038492058223					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534405	45534455	48008034	48008084	18128	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-10				GACCCGACTCCCGGCCGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0441038492058223					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534618	45534668	48008247	48008297	18129	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-11				GCGGGGTCGGTTCGGCGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29369772721444909					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534640	45534690	48008269	48008319	18130	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-12				AGGGAACAAAGCCCGCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5337919810630366					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45535039	45535089	48008668	48008718	18131	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-13				AGGACCACTAAGCGTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.070847530372088685					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534597	45534647	48008226	48008276	18132	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-14				GGTCCGGGCACCGGGATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50258484820980309					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534199	45534249	48007828	48007878	18133	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-15				TGACTGCAGGTCCGCGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.84615755756674971					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534980	45535030	48008609	48008659	18134	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-16				ACACCCGTGGCGCGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4919243225608869					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533896	45533946	48007525	48007575	18135	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-17				CGGGTTTCAGCCAAACACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.170065568954286					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534322	45534372	48007951	48008001	18136	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-18				TCTCCGCAAGCACCATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46753112292022458					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534569	45534619	48008198	48008248	18137	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-19				GCTGCTTTTGTTTCGGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46958992270075328					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45535063	45535113	48008692	48008742	18138	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-2				TAGAAATACAGACGCGTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42126205078042389					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533877	45533927	48007506	48007556	18139	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-20				TGTTAGTGGATGCTCCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059222764535842728					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534468	45534518	48008097	48008147	18140	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-21				GGGAAGCAACCTTTGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23139350792669841					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534805	45534855	48008434	48008484	18141	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-22				TGAGTCCGAGCCCAGCTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12836733469239089					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534805	45534855	48008434	48008484	18142	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-22				TGAGTCCGAGCCCAGCTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12836733469239089					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534546	45534596	48008175	48008225	18143	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-23				TGTGCTTCTAGGCACGCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21404315104924149					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534394	45534444	48008023	48008073	18144	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-24				CGGCCGAGATGGACTGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1278173207845601					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534430	45534480	48008059	48008109	18145	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-25				TGCCAGCCCAGCGCTCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1501068433218693					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534430	45534480	48008059	48008109	18146	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-25				TGCCAGCCCAGCGCTCGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1501068433218693					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534225	45534275	48007854	48007904	18147	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-26				AAGCACATGGAGGAGCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5841674794431313					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534999	45535049	48008628	48008678	18148	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-27				CAGGGGCGGTTTTTCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062388081992466982					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534021	45534071	48007650	48007700	18149	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-28				AGCTCTGGGATGTTTTATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.030977055650703481					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534922	45534972	48008551	48008601	18150	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-29				GAGGTCCCGGCGCCGACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7922046876254093					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534519	45534569	48008148	48008198	18151	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-3				TATTCCGAGGAGCGCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0402682415391791					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534253	45534303	48007882	48007932	18152	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-30				GTGGACTGAAGTTAGTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.086564284403230371					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534672	45534722	48008301	48008351	18153	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-31				ACTGCGAGCGGCGGCCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1829219483546729					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534210	45534260	48007839	48007889	18154	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-32				CGTCCGGGCCCCCAGGCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38340126861469009					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45535015	45535065	48008644	48008694	18155	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-33				AGAGTGAGACTTAGGACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.025258338409578189					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534007	45534057	48007636	48007686	18156	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-34				TTGCCACCTTAGGCAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17644380646348409					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534311	45534361	48007940	48007990	18157	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-35				TGCTTGCGGAGAGCACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6813934303127569					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533932	45533982	48007561	48007611	18158	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-36				CCATGCTCAGCTTCGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36031911309398451					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534084	45534134	48007713	48007763	18159	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-37				TGAGTAAAGGTAGCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26099868167368062					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534360	45534410	48007989	48008039	18160	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-38				GGCTAGGGAGCGGAAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.032852469531494823					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534282	45534332	48007911	48007961	18161	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-39				GCCTCCGAGAGTGGGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2821463145043609					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534961	45535011	48008590	48008640	18162	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-4				GTGTGCGGTGTAGACGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14898796855570309					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534059	45534109	48007688	48007738	18163	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-40				ACCACCCTCCTCATGGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.137806629412552					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533913	45533963	48007542	48007592	18164	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-41				ATGGACCTCAGCCTGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1058515844645158					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534629	45534679	48008258	48008308	18165	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-42				AACCGACCCCGCCCCGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22206152318936639					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534937	45534987	48008566	48008616	18166	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-43				GGGACCTCCTCCTCCGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31413274094107979					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534483	45534533	48008112	48008162	18167	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-44				CTGTGACACCCCCTTCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.019516091069780851					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534098	45534148	48007727	48007777	18168	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-45				CTCTGCGGGCAGGAGATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4983737022934312					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45535142	45535192	48008771	48008821	18169	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-46				CACCTCATTTTTAAAGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.130888619875231					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534124	45534174	48007753	48007803	18170	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-47				CATGGGACCCAGCAGAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10831900459079979					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534856	45534906	48008485	48008535	18171	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-48				TGGCCTGGCCGGCCAGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1941365224269089					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534071	45534121	48007700	48007750	18172	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-49				AGGAGGGTGGTGCTGAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63027218992528111					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534532	45534582	48008161	48008211	18173	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-5				CGCTGTTGGAGATTATTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064222468120436679					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533973	45534023	48007602	48007652	18174	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-50				ACTGAGGGCCTGTCCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072585443341629169					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534508	45534558	48008137	48008187	18175	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-51				GCGCAAGCTGGGAGGGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.23595731605802					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534238	45534288	48007867	48007917	18176	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-52				TAGTGGGGCAGAAAAGCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2733957120443451					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534176	45534226	48007805	48007855	18177	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-53				GCTGGAGAGGGTCAGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2987495431118441					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534188	45534238	48007817	48007867	18178	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-54				GACCTGCAGTCAGCTGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45955178119903928					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534724	45534774	48008353	48008403	18179	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-55				TGGGGGTGGGGCGCGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65549690961876417					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534910	45534960	48008539	48008589	18180	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-56				GCTGCCTCCGCTCCAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.359999756586171					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534685	45534735	48008314	48008364	18181	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-57				GCCACGCGGGGGCGCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47538441503734491					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45535129	45535179	48008758	48008808	18182	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-58				AAATGAGGTGTGGTAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090889839002291167					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534844	45534894	48008473	48008523	18183	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-59				GTGAGCCTCCTCCCCGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10928014224637859					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534880	45534930	48008509	48008559	18184	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-6				CGCAGCGAGACAAGTAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43625276551947162					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533958	45534008	48007587	48007637	18185	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-60				TGGAGCAGGAGTGGCACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22526388977769979					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533944	45533994	48007573	48007623	18186	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-61				TCGGGCCAGGGCACTGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067475612011120914					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45533991	45534041	48007620	48007670	18187	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-62				GTGGCAAAGGAAGGAGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78098673433548871					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534557	45534607	48008186	48008236	18188	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-63				ACAAAAGCAGCTGTGCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27649367655342832					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534382	45534432	48008011	48008061	18189	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-64				ACTGGAGAGGGGAAGAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4423286464062115					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534776	45534826	48008405	48008455	18190	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-65				CCGCTCCTCCTCCCATGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03068994846516775					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534793	45534843	48008422	48008472	18191	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-66				CAGCTGCGAGGCGGGGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10033197183646191					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534793	45534843	48008422	48008472	18192	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-66				CAGCTGCGAGGCGGGGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10033197183646191					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534950	45535000	48008579	48008629	18193	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-67				AGACGCGGGCGGGCCGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0681503558924681					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534135	45534185	48007764	48007814	18194	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-68				GCAGAGTGAGGGGTGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.7955154463087242					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534741	45534791	48008370	48008420	18195	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-69				AGGGGCGGGGGAGGTGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65584089887984931					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534334	45534384	48007963	48008013	18196	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-7				CTCTACAAAGTCCCGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58355026077386418					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534867	45534917	48008496	48008546	18197	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-70				GTAGGCTGGGCTGGCCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19138446123570349					ZBTB7C	chr18	48026671	48410752	11318				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534764	45534814	48008393	48008443	18198	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-71				AGGAGGAGCGGGGAGGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26801592621014531					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534700	45534750	48008329	48008379	18199	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-72				TGGGCCGGGGGCGGGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65886249968430921					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534753	45534803	48008382	48008432	18200	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-73				GGAGGAGCCGGGAGGGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.542392634622979					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534711	45534761	48008340	48008390	18201	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-74				CGGGGGCCAGGGCTGGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.911563008221691					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534441	45534491	48008070	48008120	18202	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+2-8				CGCTCGGAATGGAGCTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062672655559598486					ZBTB7C	chr18	48026671	48410752	18594				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534441	45534491	48008070	48008120	18203	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-8				CGCTCGGAATGGAGCTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062672655559598486					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45534660	45534710	48008289	48008339	18204	hg38	N/A	enh4832	fant55053	Enhatls83616	enhancer	SMAD2e+2-9				CCTGCGCTGCGCACTGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16829538745729961					ZBTB7C	chr18	48026671	48410752	18204				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45548936	45548986	48022565	48022615	18205	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-1				CTAATGCTGGCGCATCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79369281684643622					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45548995	45549045	48022624	48022674	18206	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-10				AGTGTGGCACCCATTTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34605125812023219					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45548964	45549014	48022593	48022643	18207	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-11				ACGCTGCGGAGAGCAGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3364781631347401					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549282	45549332	48022911	48022961	18208	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-12				GTGTTGTGTAGTATGCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047055137877134258					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549324	45549374	48022953	48023003	18209	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-13				CTGCCGGCCTGACTCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20626400675946749					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549186	45549236	48022815	48022865	18210	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-14				AGGGCAGTAAAGCATCTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74753958728961267					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549159	45549209	48022788	48022838	18211	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-15				TTTGTGCAAATTAGACGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5620778348634401					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549039	45549089	48022668	48022718	18212	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-16				GGCATGGGGACTCTGTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39532096449173282					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549090	45549140	48022719	48022769	18213	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-17				AGTGTGGCTTGGGTGGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31590400951448472					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549206	45549256	48022835	48022885	18214	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-18				ACTAAAGAATTTTCCAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.603378216083686					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549007	45549057	48022636	48022686	18215	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-19				ATTTTCCCAGGAGACACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25436084709360368					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45548949	45548999	48022578	48022628	18216	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-2				CGCAGCGTGAAGTCTAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1196693525657625					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549106	45549156	48022735	48022785	18217	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-20				TTCTGGGCTTCCTTGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14567438419813131					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549054	45549104	48022683	48022733	18218	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-21				GCAGCTCAGGCCCTGGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46929306984419961					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45548979	45549029	48022608	48022658	18219	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-22				GTGTGAGGGAGTACAGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3784654931884277					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549140	45549190	48022769	48022819	18220	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-3				CAAAGTCGCCAAGTGGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08765865584550471					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549241	45549291	48022870	48022920	18221	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-4				CAATCTGTCTAGGGTGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21996451393099559					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549124	45549174	48022753	48022803	18222	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-5				ACTAGGGGTAGCACACGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0084442829221576931					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549067	45549117	48022696	48022746	18223	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-6				GTGTCAGATCGTTGCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.060789702584578387					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549079	45549129	48022708	48022758	18224	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-7				CGATCTGACACAGTGTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.079965245053081752					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549267	45549317	48022896	48022946	18225	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-8				CACAACACCACTACATTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021111430527956859					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77942	chr18	45549299	45549349	48022928	48022978	18226	hg38	N/A	enh4832	N/A	Enhatls83616	enhancer	SMAD2e+3-9				ACCTGGACAACTGATCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65171585508027274					ZBTB7C	chr18	48026671	48410752	105				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1960
enhrx-77944	chr18	45586396	45586446	48060025	48060075	18227	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-1				GTAAAACGGTGTCTAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62879575766383555					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586011	45586061	48059640	48059690	18228	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-10				ATATCTTTGAAAAGGGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57011078285909367					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586264	45586314	48059893	48059943	18229	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-11				CTTCCCTACAGGCAGCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21530038617774119					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586284	45586334	48059913	48059963	18230	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-12				GGGAGGGTGCGACCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33322714317460722					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586076	45586126	48059705	48059755	18231	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-13				GACACTTAATTCCAAATACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2413369983627264					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586232	45586282	48059861	48059911	18232	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-14				CGGGTGGGGGGATGGACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0236794685827759					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586045	45586095	48059674	48059724	18233	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-15				TGAAAGGGAGGCTGTCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.052018661656812043					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586057	45586107	48059686	48059736	18234	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-16				TGTCAGGAAAGCTGAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48344541758476178					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45585953	45586003	48059582	48059632	18235	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-17				AAGAAGTGACAGCCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66120237259551728					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586175	45586225	48059804	48059854	18236	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-18				GGGGCAGGGGCTGTTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26244001497284047					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586319	45586369	48059948	48059998	18237	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-19				CTGCCTGCCTGGAAAAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01148334495674694					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586422	45586472	48060051	48060101	18238	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-2				CTCTACCATTTTTTTTCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.311355091711179					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586216	45586266	48059845	48059895	18239	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-20				TCCTGGTCCCCAGTCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50238878911646412					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586199	45586249	48059828	48059878	18240	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-21				GTCTCTCCCCAGCTGCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35734886043594732					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45585926	45585976	48059555	48059605	18241	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-22				GGTCTCCTGGAGGGAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.644824218064771					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586138	45586188	48059767	48059817	18242	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-23				CATAAAAAAAAATACTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41557253064947608					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586296	45586346	48059925	48059975	18243	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-24				AGGAGGAAGAAGCCGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30764407473877781					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586188	45586238	48059817	48059867	18244	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-25				CTGGGGAGAGACTGGGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25183642643682708					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45585940	45585990	48059569	48059619	18245	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-26				AGGGGCAGGAGGGCCTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.2080567581414279					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586359	45586409	48059988	48060038	18246	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-3				AATAAACACCAGTTGAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37900350618319639					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45585988	45586038	48059617	48059667	18247	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-4				GCTACTAGAGATTTATTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.362069366871532					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586253	45586303	48059882	48059932	18248	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-5				CGCCCAGGCAGCTTCCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18983162410550861					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586109	45586159	48059738	48059788	18249	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-6				TAGCTCCTAAATTGTTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097471343898186319					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586087	45586137	48059716	48059766	18250	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-7				GATTAAGTGTACCATGTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.83074627669478385					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586330	45586380	48059959	48060009	18251	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-8				GAGAAATAAGCCTGCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47474549745092048					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77944	chr18	45586382	45586432	48060011	48060061	18252	hg38	N/A	enh17661	N/A	Enhatls83618	enhancer	SMAD2e+4-9				AGGAGAGCCCCTTTGTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45684765145968692					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1962
enhrx-77945	chr18	45688347	45688397	48161976	48162026	18253	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-1				GGCGGTAACCGGGTAACCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42488922103395771					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688388	45688438	48162017	48162067	18254	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-10				CAGTGCGGGTCCCGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2445691555112009					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688388	45688438	48162017	48162067	18255	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-10				CAGTGCGGGTCCCGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2445691555112009					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688261	45688311	48161890	48161940	18256	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-11				GGAGCGATGTGAGAATGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17607405006703331					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688042	45688092	48161671	48161721	18257	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-12				GGCAGCCGAGTGAACGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42028552132451952					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688229	45688279	48161858	48161908	18258	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-13				GGAAACAGGCTGCGGCCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.399148711513244					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688400	45688450	48162029	48162079	18259	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-14				GACCCGCACTGACCCCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2257821627113365					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688400	45688450	48162029	48162079	18260	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-14				GACCCGCACTGACCCCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2257821627113365					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688491	45688541	48162120	48162170	18261	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-15				GCAGGGCTTCGTGCCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39284772261185807					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687934	45687984	48161563	48161613	18262	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-16				TCTCAGAGGTCAGGCGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.518338165390605					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688190	45688240	48161819	48161869	18263	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-17				AGGGCGATGGCTCCCGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35087737941296793					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688331	45688381	48161960	48162010	18264	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-18				CGCGGCACCGCCCCTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1575992999738631					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688480	45688530	48162109	48162159	18265	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-19				ACGAAGCCCTGCCTGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44452996507547821					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687890	45687940	48161519	48161569	18266	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-2				GCGAACCAGTCTGAACAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082565845436899432					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688544	45688594	48162173	48162223	18267	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-20				GCCTCGGGGACGCCTGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43380067871579192					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688411	45688461	48162040	48162090	18268	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-21				ACCCCGCAGGGGGCGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.403661650853665					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687948	45687998	48161577	48161627	18269	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-22				CCTCTGAGAAAGCAGAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25622557259035927					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688250	45688300	48161879	48161929	18270	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-23				AGAATGCGGAGGAGAGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.002004484017025					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688012	45688062	48161641	48161691	18271	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-24				CTGCGGGCAGGCACGGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029268391846071561					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687966	45688016	48161595	48161645	18272	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-25				GCTGTGGTTGCTTCATGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18069041038983					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688370	45688420	48161999	48162049	18273	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-26				TGAGAGGCCGGCGCCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8924264297902913					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688370	45688420	48161999	48162049	18274	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-26				TGAGAGGCCGGCGCCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8924264297902913					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688159	45688209	48161788	48161838	18275	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-27				GCCGCGGGGGCGCAGAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.629701665686675					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688454	45688504	48162083	48162133	18276	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-28				GCCAGACCCCCCGCCGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043102252790318332					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688297	45688347	48161926	48161976	18277	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-29				CACCCGCCCGCCTCCCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23370220066765751					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688358	45688408	48161987	48162037	18278	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-3				CCGGTTACCGCCTGAGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088775190117003966					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688469	45688519	48162098	48162148	18279	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-30				GCCGCAGGCCGCCCACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6779780860149891					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688104	45688154	48161733	48161783	18280	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-31				TAGAGGAGGGGCCTCCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.418328057955168					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688177	45688227	48161806	48161856	18281	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-32				GCGGCCTCTCTCTCCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21919270372979929					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688282	45688332	48161911	48161961	18282	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-33				GGCGGGTGGGGAGGTCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1148791260017251					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688310	45688360	48161939	48161989	18283	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-34				CGCCGGGCCGCGGCCTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688029	45688079	48161658	48161708	18284	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-35				ACGCTGCAGGAAGGGGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2289928254364253					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688214	45688264	48161843	48161893	18285	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-36				CTCCCGGGCGCCCCTCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1233349363100888					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688121	45688171	48161750	48161800	18286	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-37				CCTCTATCCCCGCCCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2322489795192815					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687912	45687962	48161541	48161591	18287	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-38				GCCGGCAGGGAGAGAAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0897429655721877					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688135	45688185	48161764	48161814	18288	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-39				AGAGGGCGGGGCGCCCGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.5366806226529					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687856	45687906	48161485	48161535	18289	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-4				AGCGTGGGCCCGGCGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687856	45687906	48161485	48161535	18290	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-4				AGCGTGGGCCCGGCGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688532	45688582	48162161	48162211	18291	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-40				TGGAGGGCAGTGCCAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30055944763552361					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688055	45688105	48161684	48161734	18292	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-41				CTCGGCTGCCCGGCCCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688203	45688253	48161832	48161882	18293	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-42				GGCGCCCGGGAGGAGGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4831659597733369					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688091	45688141	48161720	48161770	18294	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-43				TCCGGAGCGGGGCGGGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.017731287820455351					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688074	45688124	48161703	48161753	18295	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-44				CTGGGGCGGGGCGCCCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14554298269113969					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688147	45688197	48161776	48161826	18296	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-45				CAGAGTGGAGGGAGAGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.64686075388036					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688585	45688635	48162214	48162264	18297	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-46				AGGCTGCAGGGAAGGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.304765888113343					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688574	45688624	48162203	48162253	18298	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-47				AAGGAGGCTGGGGCCAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1129339231263036					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688508	45688558	48162137	48162187	18299	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-5				ACCCGGCTGTAGTTATCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20953113013085151					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688561	45688611	48162190	48162240	18300	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+5-6				CGAGGCGCAAACACCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22683487481708139					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45688001	45688051	48161630	48161680	18301	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-7				CACGGAGTCCGGGGCGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13032815800259251					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687978	45688028	48161607	48161657	18302	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-8				GCAACCACAGCCGCTCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44574919986710321					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45687879	45687929	48161508	48161558	18303	hg38	N/A	N/A	fant55060	Enhatls83619	enhancer	SMAD2e+5-9				TGAACAGGCCGGGCAACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052214299478149963					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866127	45866177	48339756	48339806	18304	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-1				CCCTCATAGGAGGGTCGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.148137157145244					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866306	45866356	48339935	48339985	18305	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-10				ACTTGGAGTGTGAGCTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10201235981552351					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866114	45866164	48339743	48339793	18306	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-11				CCTTTGGATTCTTCCCTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20443897502977229					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45865960	45866010	48339589	48339639	18307	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-12				ATTCTTTCCAGCAAGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49119733162070872					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866330	45866380	48339959	48340009	18308	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-13				ACTTCTCTGCAAAGCAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17723680887275731					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866255	45866305	48339884	48339934	18309	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-14				CCACTGCTTTGGGAGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89913787745806339					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45865932	45865982	48339561	48339611	18310	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-15				TTGGCTGTTTCATTTACTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13871800973164761					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866016	45866066	48339645	48339695	18311	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-16				CTCAGGGGTGGGGGATGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.31545026071103					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866179	45866229	48339808	48339858	18312	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-17				TAAGAAAGACAAGAATGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.503606709235048					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866029	45866079	48339658	48339708	18313	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-18				GATGAGTGGGAATGGGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4341723118091057					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866042	45866092	48339671	48339721	18314	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-19				GGGAAGGAGGAGGGGGACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9312360594975559					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866204	45866254	48339833	48339883	18315	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-2				CTGAGCCGCTCCTGTTAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1047319769092442					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866244	45866294	48339873	48339923	18316	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-3				GCGATAAACAGCCACTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18189465546953509					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866219	45866269	48339848	48339898	18317	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-4				CGGCTCAGGCACAAAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27202889847043732					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866070	45866120	48339699	48339749	18318	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-5				TTGCCCTGCTATGGGGGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53268528480392341					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866004	45866054	48339633	48339683	18319	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-6				CTTCCAAGTCACCTCAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43995729499308811					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45865978	45866028	48339607	48339657	18320	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-7				GATGAAATTAACCTAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21223282182355491					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866292	45866342	48339921	48339971	18321	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-8				CTGTAGAGGGCCAAGTTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.138680719746911					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45866098	45866148	48339727	48339777	18322	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+6-9				GAGGAGAACAATCATGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43041936886820831					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877846	45877896	48351475	48351525	18323	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-1				GGTGGTATACTTTCCCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64493790247790039					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878229	45878279	48351858	48351908	18324	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-10				GTCAGAGGGAAATCTCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10252291034142021					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878195	45878245	48351824	48351874	18325	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-11				AGCTTGGCTTGCTGCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038303440997432277					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878096	45878146	48351725	48351775	18326	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-12				TAATCAGTCACTGCTGTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23496577824170439					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878317	45878367	48351946	48351996	18327	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-13				TATCTCTAGTTCCTGTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28444126573684192					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878281	45878331	48351910	48351960	18328	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-14				GGGGAGTGCTAAGTCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19780105550245439					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877980	45878030	48351609	48351659	18329	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-15				TGCTCTTAATCCATTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.301528658368047					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877831	45877881	48351460	48351510	18330	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-16				AAGCCAACTGGTTTCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94171411321650411					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878002	45878052	48351631	48351681	18331	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-17				GAGATGTTGCTTCAACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50727741473676069					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878306	45878356	48351935	48351985	18332	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-18				AACCTGAGAGCCCTGATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1906967524027211					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878070	45878120	48351699	48351749	18333	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-19				AATCACTTATTCAGGAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25324006322904241					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877806	45877856	48351435	48351485	18334	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-2				AAGCCTGTAGAAAGTCCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73231984712570231					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878242	45878292	48351871	48351921	18335	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-20				TCCCTCTGACAGAGCATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.047733229586135					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878121	45878171	48351750	48351800	18336	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-21				ATTTCACAGCAGCCAGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21236747876407541					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878027	45878077	48351656	48351706	18337	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-22				AGTTGACTTCAGCACATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14626280733334729					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878180	45878230	48351809	48351859	18338	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-23				CAAGGAGGGGCCAACAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19708787356559371					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877791	45877841	48351420	48351470	18339	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-24				AGCAAACTTCTCCTCCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.041011479743919492					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877910	45877960	48351539	48351589	18340	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-25				GAGGAGATAACAAATGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46980792261698018					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878295	45878345	48351924	48351974	18341	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-26				GGCTCTCAGGTTCACCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044117658257325443					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877921	45877971	48351550	48351600	18342	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-27				AAATGCATTTGGGTTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28988739009189818					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878359	45878409	48351988	48352038	18343	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-28				GGCTAAATGGAGGTGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9431926386124361					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878261	45878311	48351890	48351940	18344	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-29				AGGGGGCTGGAGCAGACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7897208178503					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877944	45877994	48351573	48351623	18345	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-3				TTTCTTAACACGGTGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1054005082139351					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878341	45878391	48351970	48352020	18346	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-30				AAGGGGGCTGGGCAGAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64094902028958112					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877859	45877909	48351488	48351538	18347	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-4				GTATACCACCACTGTCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29035399119035338					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877819	45877869	48351448	48351498	18348	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-5				CTACAGGCTTGCAAGCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16071923586423059					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878153	45878203	48351782	48351832	18349	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-6				TGAGGGAACGAGCACTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066214177278866818					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878213	45878263	48351842	48351892	18350	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-7				AAGCTCAGAATCCTACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024348724701775421					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45877886	45877936	48351515	48351565	18351	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-8				TGTAGCACATCCATGGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66380907650113685					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	45878139	45878189	48351768	48351818	18352	hg38	N/A	N/A	N/A	Enhatls83619	enhancer	SMAD2e+7-9				CTCTTTGGGTTCCGTAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0095353536093416291					ZBTB7C	chr18	48026671	48410752	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014939	46014989	48488568	48488618	18353	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-1				CCTCAGGAATTTTGTCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55202719411960921					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015133	46015183	48488762	48488812	18354	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-10				TGATTAATGCCTGAGCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34661871658764593					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015118	46015168	48488747	48488797	18355	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-11				ATGTTTGGAGCCCTGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29063179706967779					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015046	46015096	48488675	48488725	18356	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-12				TACATTATCTTGAGCTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2377849260175692					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015002	46015052	48488631	48488681	18357	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-13				CACTCACAGAGATTTGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031166235534786622					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015099	46015149	48488728	48488778	18358	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-14				ACATCACAGGCATTCCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74998388991697906					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015160	46015210	48488789	48488839	18359	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-15				CTCAGTCAACATTTATCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17410256879709551					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015030	46015080	48488659	48488709	18360	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-16				TAATGTAGAAAGCTGGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.413195578621576					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014980	46015030	48488609	48488659	18361	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-17				GCCCTTTTTGTCTCTTAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1036333188329385					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014879	46014929	48488508	48488558	18362	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-18				AGTCTTGTTGATTTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048129532284008923					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014923	46014973	48488552	48488602	18363	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-19				GAGGGGAGGCCTCTAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12938362666598019					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015181	46015231	48488810	48488860	18364	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-2				AGCATACTCTGTTAGGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41139109872343987					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014799	46014849	48488428	48488478	18365	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-20				CTGATATATATACAACAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43057080308394269					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014860	46014910	48488489	48488539	18366	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-21				CTGGCCAAGACCCTCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16535222230760149					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015085	46015135	48488714	48488764	18367	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-22				GCAGCTTCTGCATTCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26114767686827839					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015259	46015309	48488888	48488938	18368	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-23				GATTTTAAATAGTCTTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014956	46015006	48488585	48488635	18369	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-3				TATTATACAGACCCTGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25774583034733439					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014849	46014899	48488478	48488528	18370	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-4				ACAAACGTCATCCACAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4786939384010089					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46014901	46014951	48488530	48488580	18371	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-5				TATGACTTGGAAATTCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.97856279327048445					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015144	46015194	48488773	48488823	18372	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-6				AGGCATTAATCATCAACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12899183917193141					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015198	46015248	48488827	48488877	18373	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-7				CCCTGGTGTGCCTAAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30986793350173369					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015231	46015281	48488860	48488910	18374	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-8				TATCTTCTGCAACCTTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1187162110922719					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46015215	46015265	48488844	48488894	18375	hg38	N/A	enh17675	N/A	Enhatls83619	enhancer	SMAD2e+8-9				AGAGGGGTACCCTTTCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.2973651535967727					CTIF	chr18	48539030	48863217	48079				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057351	46057401	48530980	48531030	18376	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-1				GCCTATTAGCTTATGTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22250594813912461					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057523	46057573	48531152	48531202	18377	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-10				CAAGTCTGGGACTTGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.922523810621147					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057308	46057358	48530937	48530987	18378	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-11				AGCAGTGTAGGGGAAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0312859436123194					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057402	46057452	48531031	48531081	18379	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-12				TCTGCCACCTCTCCCAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19243432936712951					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057321	46057371	48530950	48531000	18380	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-13				CTACACTGCTCCCTTCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.013973650924858					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057379	46057429	48531008	48531058	18381	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-14				GGAGGTTTTCAGAAAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52179486510085682					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057484	46057534	48531113	48531163	18382	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-15				TCTGCACAAAATAAATTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18334057547577781					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057414	46057464	48531043	48531093	18383	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-2				TTGGTCAGGGAACCCTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19752750660349741					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057433	46057483	48531062	48531112	18384	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-3				GAAAGCACCAAGCTGCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.090774465198017157					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057337	46057387	48530966	48531016	18385	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-4				GTGGACTGGGAGACCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78149639215508671					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057598	46057648	48531227	48531277	18386	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-5				ATGTGTCTTCAGTATCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22340281597965081					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057466	46057516	48531095	48531145	18387	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-6				GCAGAGCTAGGTGATTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1180165615363402					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057559	46057609	48531188	48531238	18388	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-7				GACTCCTGTGAAGGTGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0836899019333162					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057629	46057679	48531258	48531308	18389	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-8				GCTGCTGATGAGGCAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.032539045731512971					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-77945	chr18	46057536	46057586	48531165	48531215	18390	hg38	N/A	enh102582	N/A	Enhatls83619	enhancer	SMAD2e+9-9				AGCTGATTTTCAGCAAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31459242739255949					CTIF	chr18	48539030	48863217	6892				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	1963
enhrx-78099	chr18	48636619	48636669	51110249	51110299	18391	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-1				ACCTAAGACACCCTGGACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1083029200309293					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636828	48636878	51110458	51110508	18392	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-10				TGCGTGGTATCCCCAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29020097870689249					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636958	48637008	51110588	51110638	18393	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-11				CAATGTCCCGGGACCCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3055115974481191					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636682	48636732	51110312	51110362	18394	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-12				TTTGCCCCTTGTGGGGCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23087981345072309					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637115	48637165	51110745	51110795	18395	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-13				CACCTGGATTCTGCGGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044829284319158683					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636643	48636693	51110273	51110323	18396	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-14				GGCACCCCGGCTCTTTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.526863572202259					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637162	48637212	51110792	51110842	18397	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-15				CACAACAGGATGTCTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3218930336322306					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636630	48636680	51110260	51110310	18398	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-16				TTTCCCAGGGTCCACCGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52935578771370029					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636671	48636721	51110301	51110351	18399	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-17				ACAAGGGGCAAACCCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50307338842306959					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637099	48637149	51110729	51110779	18400	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-18				GCCCGGACGCTCCCAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8319006387754081					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637137	48637187	51110767	51110817	18401	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-19				GATCTTCACTGTGAGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040514840713893933					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636995	48637045	51110625	51110675	18402	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-2				GGACTGCGGTTGACGACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.338148985980905					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637067	48637117	51110697	51110747	18403	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-20				CTGCCTTCAGAGAGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35110187578275642					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637007	48637057	51110637	51110687	18404	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-21				AACCGCAGTCCCTGAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1069975976727329					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637031	48637081	51110661	51110711	18405	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-22				CCTGTGCAGAGCCCGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78638940815309755					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636728	48636778	51110358	51110408	18406	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-23				GTAGCCTGGGAACTGGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36221525507041741					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637085	48637135	51110715	51110765	18407	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-24				CGTCCGGGCAAGGCTGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62332199355199824					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637043	48637093	51110673	51110723	18408	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-25				GGTCCAAGCCCACCCAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.182918494280096					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636915	48636965	51110545	51110595	18409	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-26				TGGGAGGACAGAGGCGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32393268666378339					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636659	48636709	51110289	51110339	18410	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-27				GGGTGCCCCCGCCCTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27746317179149821					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636812	48636862	51110442	51110492	18411	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-28				AGGGCCCCAGCGCCTGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071390518465082847					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636746	48636796	51110376	51110426	18412	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-29				CAGGGTCTGCAGGGCGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52773733444630966					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636941	48636991	51110571	51110621	18413	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-3				ACATTGTCTATCTAGCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30916773198334108					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636793	48636843	51110423	51110473	18414	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-30				AAGAGGGCAGTGGGGTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.126170904331111					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636926	48636976	51110556	51110606	18415	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-31				TCTGTCCTCCCAGCTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54835866555859691					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637173	48637223	51110803	51110853	18416	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-32				CATCCTGTTGTGTCCAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13365540572851051					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636760	48636810	51110390	51110440	18417	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-33				CGGGCTGGGAGCAGGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2196176396259378					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636776	48636826	51110406	51110456	18418	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-34				CAGGAGGGAGGAGAGGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.690774069419353					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48637184	48637234	51110814	51110864	18419	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-35				GTCCAGAATTGGTGGGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37125780887412152					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636882	48636932	51110512	51110562	18420	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-4				CTGCTCCCTTCGCGGGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01209290017785981					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636843	48636893	51110473	51110523	18421	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-5				ACCACGCAGCCGAGTTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0245518468764565					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636859	48636909	51110489	51110539	18422	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-6				CGACACCCAGTGGTGGCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.010256561307187139					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636971	48637021	51110601	51110651	18423	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-7				TTGGTCCACTACGCCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1587866608098393					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636714	48636764	51110344	51110394	18424	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-8				AAGCAGCGCTGACGGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048025180317971143					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48636899	48636949	51110529	51110579	18425	hg38	N/A	N/A	N/A	Enhatls83785	enhancer	SMAD4e-1-9				GAGCAGGCGCGCGTTTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13509995621340121					SMAD4	chr18	51028527	51085045	24341				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78104	chr18	49089955	49090005	51563585	51563635	18426	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-1				GTTTAATCAATCAGCGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1289373989224028					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090032	49090082	51563662	51563712	18427	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-10				GGGTAGAGCTCACTAATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37075341151339469					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090838	49090888	51564468	51564518	18428	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-11				TCATGTCTTACCACGTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.493821493435469					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090276	49090326	51563906	51563956	18429	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-12				CTGCTTCCACCCGGTTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31835896322001378					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090241	49090291	51563871	51563921	18430	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-13				TCTCTACACAGCTTGGCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11039530569913671					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090825	49090875	51564455	51564505	18431	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-14				CGTCCTCAGGTGAATCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021160018335418879					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090087	49090137	51563717	51563767	18432	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-15				ATCCCCCAAATTGGGGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70429282847489594					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089701	49089751	51563331	51563381	18433	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-16				GTTACGCTTCTTTAAAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19348608439831419					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090667	49090717	51564297	51564347	18434	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-17				ATTATCCCTAAGTTACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1038974981990281					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090111	49090161	51563741	51563791	18435	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-18				CTTCTGCTTCGAGTACATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18401468027916881					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090507	49090557	51564137	51564187	18436	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-19				CCTGTAGTTCTTCCTGTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16812835610876359					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090340	49090390	51563970	51564020	18437	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-2				TTCATCCGTCCTGAACGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1027806381448505					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090373	49090423	51564003	51564053	18438	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-20				GTCTCAGTTTAGCATCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.085009018545138856					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090636	49090686	51564266	51564316	18439	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-21				GTCCTTCGTTTGTAAAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08299959839693076					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090770	49090820	51564400	51564450	18440	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-22				AATGTGTTTCTGCCACGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89334896295087618					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089895	49089945	51563525	51563575	18441	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-23				CCTCACAGGAAGTGTTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2717976664531998					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089929	49089979	51563559	51563609	18442	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-24				GCTAGATTCTCCATCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1049933035237192					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089719	49089769	51563349	51563399	18443	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-25				GCAGGTGACAGGTTGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1521274453054689					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090406	49090456	51564036	51564086	18444	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-26				ACAATGCCAGGCTTCCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080797601729191579					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090682	49090732	51564312	51564362	18445	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-27				TAAGACTTTTCTAAACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.203482074632027					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090607	49090657	51564237	51564287	18446	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-28				ATCTAGTTCAAATCAGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32285770502783362					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089782	49089832	51563412	51563462	18447	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-29				GCAACTTTTCAGATAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5602519542229295					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089827	49089877	51563457	51563507	18448	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-3				GCAAGCTGTGTCGGTGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1058687522266004					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090392	49090442	51564022	51564072	18449	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-30				AGACTCTCTGAAGGCCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49688678023619881					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090428	49090478	51564058	51564108	18450	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-31				TGTAGCCATTTCTTCCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23719426016209211					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090526	49090576	51564156	51564206	18451	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-32				GTGGCTCCTGGTCAGTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44738289568476353					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090310	49090360	51563940	51563990	18452	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-33				GTTGCCCATTTCCTCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072871226008915754					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090442	49090492	51564072	51564122	18453	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-34				ATGTGAGGGGAGAGCCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53555071702443968					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090747	49090797	51564377	51564427	18454	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-35				GCTCAGAGCGGCCCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58530655237728924					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089743	49089793	51563373	51563423	18455	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-36				CGCTCAGAGCCAGGCAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15257699219638229					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090792	49090842	51564422	51564472	18456	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-37				GAATACAGGAGGAGTTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18555123584958519					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090759	49090809	51564389	51564439	18457	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-38				CAGAAACACATTCCAAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34494297938293461					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090850	49090900	51564480	51564530	18458	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-39				GTAAGACATGAAGATCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74631663931587433					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090781	49090831	51564411	51564461	18459	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-4				GCCACGACAAGGAATACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55594328604129772					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090136	49090186	51563766	51563816	18460	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-40				AGCAGCACAGAGTTCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.136083551509724					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089881	49089931	51563511	51563561	18461	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-41				TTTTTTCAGAAGTTCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5002795741276086					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090735	49090785	51564365	51564415	18462	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-42				CCTCTTCCATGAGCTCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.463617848666606					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090299	49090349	51563929	51563979	18463	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-43				TGCCACTGCCACCTGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.121426657572537					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090455	49090505	51564085	51564135	18464	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-44				TGGCAGGCTGTGAATGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17614348085738449					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090073	49090123	51563703	51563753	18465	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-45				GGCAACAGGAGGCACTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.409434052428989					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090537	49090587	51564167	51564217	18466	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-46				TCAGTCACTGGGCAAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.652960799366642					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090218	49090268	51563848	51563898	18467	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-47				AGGGTTTGAGAGCAATGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.093188662906022943					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090175	49090225	51563805	51563855	18468	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-48				ACAACAACAAAAATCTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80404549512396561					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090580	49090630	51564210	51564260	18469	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-49				GACAGACAGAGAGAGAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72857452196120909					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089804	49089854	51563434	51563484	18470	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-5				AAGGGGCCCCGTGGGACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0287000150169679					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089686	49089736	51563316	51563366	18471	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-6				AGCGTAACATCCAAGCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097291402884197062					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090468	49090518	51564098	51564148	18472	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-7				CAGCCTGCCACTTAAAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1737410334956857					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49089997	49090047	51563627	51563677	18473	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-8				GAGCCAAGGAATTTCACGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21578883856462791					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49090011	49090061	51563641	51563691	18474	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-10-9				CCTTGGCTCTGATTGTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51316812912751675					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096673	49096723	51570303	51570353	18475	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-1				GCCAAGAGAAGGAATTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3388055432702769					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096905	49096955	51570535	51570585	18476	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-10				GAAAATTTTGGGGGATGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48393086217197212					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096486	49096536	51570116	51570166	18477	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-11				TCTTTTAATCACCTGGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19727590592439781					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096692	49096742	51570322	51570372	18478	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-12				CAGGATAATGTCATCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20958913572255389					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096594	49096644	51570224	51570274	18479	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-13				GTCAAAGCGGGGTTGTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56875574211058544					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096662	49096712	51570292	51570342	18480	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-14				AGCCAGGATGAGCCAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66326391616056668					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096804	49096854	51570434	51570484	18481	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-15				GGGGATATTATGGCTTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30290749411881429					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096551	49096601	51570181	51570231	18482	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-16				TGGGGCTGTTTTATAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.549027203038906					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096916	49096966	51570546	51570596	18483	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-17				GGGATGGTATGGAGAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30239731196545538					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096761	49096811	51570391	51570441	18484	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-18				TAAGGCAGGAACTGGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32825646052997542					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096845	49096895	51570475	51570525	18485	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-19				TCTTATTAATATAAGAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096563	49096613	51570193	51570243	18486	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-2				ATAAGATTTGGGTAGGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90348767129461294					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096723	49096773	51570353	51570403	18487	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-21				GGCCATTTTCACTTCTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63779109392288424					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096785	49096835	51570415	51570465	18488	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-22				TGTGTACGTGCAGGTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.434435222416435					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096517	49096567	51570147	51570197	18489	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-3				GTCTGAAAAAAGAGTCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57062921396016741					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096865	49096915	51570495	51570545	18490	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-4				AGAAAAATAAAACAAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.976438910354381					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096893	49096943	51570523	51570573	18491	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-5				TGTTGGGACGGTGAAAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1217763743206467					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096532	49096582	51570162	51570212	18492	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-6				CAGCAAGGGGAGACAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99643171727172208					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096876	49096926	51570506	51570556	18493	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-7				ACAAAATAGTGGTAAAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45144189661288192					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096609	49096659	51570239	51570289	18494	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-8				TTCTCTGGCGGGCAGAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.351370798604307					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49096583	49096633	51570213	51570263	18495	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-11-9				GGGAAATTACAGTCAAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1212955736887316					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100516	49100566	51574146	51574196	18496	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-1				TCCTTTTCTACAGACCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39129727356665389					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100437	49100487	51574067	51574117	18497	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-10				GGGTTGGGGAGTAGAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.407937571549513					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100571	49100621	51574201	51574251	18498	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-11				GGACTGAGAGAACAGGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3569988159838911					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100496	49100546	51574126	51574176	18499	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-12				TGGTCTCTCCCCTCCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7356527151127539					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100377	49100427	51574007	51574057	18500	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-13				CGCAGAATGAAACTGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.032646296105505					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100324	49100374	51573954	51574004	18501	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-14				GCTTCAGCCACCTTTTTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094830522494432135					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100393	49100443	51574023	51574073	18502	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-15				AAGCTGGAACAGGTGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40186062802398009					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100483	49100533	51574113	51574163	18503	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-16				TGGTGAGGGGCAGCCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46375240997052131					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100695	49100745	51574325	51574375	18504	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-17				AGATAATTCTTGTCATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3529991816684941					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100647	49100697	51574277	51574327	18505	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-18				ACAATGTGTAAAAGAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40124002127642849					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100335	49100385	51573965	51574015	18506	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-19				CTTTTTAAGAGGAAATTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12952423739532029					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100353	49100403	51573983	51574033	18507	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-2				CTAGCCCTCCCCCACCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1923353320913718					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100276	49100326	51573906	51573956	18508	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-20				GAGAGGTTGGATAAAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12673071002206959					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100550	49100600	51574180	51574230	18509	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-21				ACTCAGCGACGCTTGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1231553483611763					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100711	49100761	51574341	51574391	18510	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-22				ATTATCTAGATCTTGTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.083412977444275033					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100665	49100715	51574295	51574345	18511	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-23				GTCTGAGGTGCCTGACATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51033100241404417					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100680	49100730	51574310	51574360	18512	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-24				TAAAATGGGCAAATGGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.168062152588939					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100307	49100357	51573937	51573987	18513	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-25				TGAAGCTAAAGGCATAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3858421918203641					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100614	49100664	51574244	51574294	18514	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-3				CTCTCTGTTCCCAATGCGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1174385824833219					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100469	49100519	51574099	51574149	18515	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-4				GACCTGGCTCCGCCTGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16561185844177989					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100247	49100297	51573877	51573927	18516	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-5				TGAAAGAGCCTAAACACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22769581049435941					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100453	49100503	51574083	51574133	18517	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-6				GCTGAGGAAGAATTAGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65580929755974615					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100583	49100633	51574213	51574263	18518	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-7				CAGGCGGGAGGGAAAGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7501430692396049					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100422	49100472	51574052	51574102	18519	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-8				GATAAAAGGATTATAGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.205289894692313					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78104	chr18	49100259	49100309	51573889	51573939	18520	hg38	N/A	N/A	N/A	Enhatls83790	enhancer	SMAD4e-12-9				AACACTAACGGATTTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17548568096035591					MEX3C	chr18	51174549	51218333	344180				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2122
enhrx-78105	chr18	49137100	49137150	51610730	51610780	18521	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-1				TGACCATGAAGTGGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5385024578576465					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136994	49137044	51610624	51610674	18522	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-10				CACTCATTATCAGAACAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2124366107184506					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136900	49136950	51610530	51610580	18523	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-11				GAAAAGTGCCAAGTGAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13889619390590319					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136827	49136877	51610457	51610507	18524	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-12				CATGGTTGTAAGTTTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33507035558273418					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136867	49136917	51610497	51610547	18525	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-13				AGCAAGACATCTTTTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69093748024073343					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137034	49137084	51610664	51610714	18526	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-14				TCAAGGGAGGGACCAGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.019676940478969					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137050	49137100	51610680	51610730	18527	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-15				TCATAATCCCTACATGTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79374339092723967					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136878	49136928	51610508	51610558	18528	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-16				TTTTTCACAAGGTGGCAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25204308819445931					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136939	49136989	51610569	51610619	18529	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-17				TGAGTTCTCAAGAGATCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48704338166377231					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136964	49137014	51610594	51610644	18530	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-18				CACTATCAGAAGAACAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13427520701674051					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136928	49136978	51610558	51610608	18531	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-19				GAGATCTGATGGTTTTATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53516037216679857					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137160	49137210	51610790	51610840	18532	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-2				CGGAAAGCCTTGGTCCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40103538795755928					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137207	49137257	51610837	51610887	18533	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-3				GTGCTCCAAAGTAGACAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30761843997200983					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137114	49137164	51610744	51610794	18534	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-4				GCTGTCCTTCCACCCCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.030211963026856359					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137174	49137224	51610804	51610854	18535	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-5				ATAGCTCAACAATGCCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25595517747699992					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137133	49137183	51610763	51610813	18536	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-6				CAGCCTGCTGATGGTGGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.083229598983968214					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49137023	49137073	51610653	51610703	18537	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-7				ACCAGATGGAGGTAATTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.588337645599972					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136845	49136895	51610475	51610525	18538	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-8				TTCCCATTCACCTTCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39244670593807007					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49136812	49136862	51610442	51610492	18539	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-13-9				GGCATAGCTTGGAAGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2001497479934746					MEX3C	chr18	51174549	51218333	376244				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149185	49149235	51622815	51622865	18540	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-1				CCGGAGCAGGGGGGCTAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08695482808847782					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149277	49149327	51622907	51622957	18541	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-10				CTCTGACAGCTGCGGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056019169251798853					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149305	49149355	51622935	51622985	18542	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-11				GTTTGGTTTAGCAGCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0047932680529412068					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149174	49149224	51622804	51622854	18543	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-12				TGGTGAGGCCTCCGGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16936678012762951					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149439	49149489	51623069	51623119	18544	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-13				GGTAGTAAGAGAGCTATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.437909172446816					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149262	49149312	51622892	51622942	18545	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-14				TGTCAGAGCAGCGTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.331298268552289					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149054	49149104	51622684	51622734	18546	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-15				AGGATGGTTAAAATAGTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0302410857613289					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149072	49149122	51622702	51622752	18547	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-16				ATCCTCCCCCACTGCCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.145057656521913					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149146	49149196	51622776	51622826	18548	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-17				GCAAATGCCTGGAAGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0879796407335036					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149351	49149401	51622981	51623031	18549	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-18				TCCAGTCTGAGGCAGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34606991620427108					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149087	49149137	51622717	51622767	18550	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-19				ATTCCTTTCCAGCTGCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19205688029411111					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149288	49149338	51622918	51622968	18551	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-2				GCGGATCTCTGGAGTTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.239904186844956					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149098	49149148	51622728	51622778	18552	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-20				CTGGAAAGGAATCAGCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44433757735507151					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149398	49149448	51623028	51623078	18553	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-21				GTCCAGGAACAGAAAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29951829476060082					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149382	49149432	51623012	51623062	18554	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-22				GGTGAGCAGAGAGAGAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039065524581891713					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149362	49149412	51622992	51623042	18555	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-23				ACCCCACCCCCTCCAGTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043042715226737971					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149248	49149298	51622878	51622928	18556	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-24				GGCTTCCCCCTCCTCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1054322084700034					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149333	49149383	51622963	51623013	18557	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-3				TATTGGATAGCAGGGTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47280616726489871					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149316	49149366	51622946	51622996	18558	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-4				CAGCTGCCCTGGCTAATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1742087765210564					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149121	49149171	51622751	51622801	18559	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-5				GAGTTCCCAGAGCGTCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.059494554242449961					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149227	49149277	51622857	51622907	18560	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-6				AAGGCTTGGTGGACCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18685879175476011					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149208	49149258	51622838	51622888	18561	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-7				CGTCATCTGGCCACCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27841446157360811					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149159	49149209	51622789	51622839	18562	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-8				AGGCATTTGCCCATCTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047677854000719749					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49149417	49149467	51623047	51623097	18563	hg38	N/A	enh32685	N/A	Enhatls83791	enhancer	SMAD4e-14-9				CAGGGAGGGGAACGATATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55424546170378608					MEX3C	chr18	51174549	51218333	393600				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178154	49178204	51651784	51651834	18564	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-1				CCTGGAATTACTTAGCAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33589923120530751					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178180	49178230	51651810	51651860	18565	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-10				ATTTGGCCAACATGGCAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1177679711206939					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178399	49178449	51652029	51652079	18566	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-11				TAACACTCTTCTATCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56900528895321634					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178592	49178642	51652222	51652272	18567	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-12				ACTTCTCTGCACTATCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38820890457945578					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178295	49178345	51651925	51651975	18568	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-13				GGATGCAGTAAAAGCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30971110997660178					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178511	49178561	51652141	51652191	18569	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-14				CATCACTTGATGTCTTAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3876091859406669					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178202	49178252	51651832	51651882	18570	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-15				GCAGGAGCAACACTCCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79588507771788131					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178497	49178547	51652127	51652177	18571	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-16				TTAATTTGGATTATGCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.202808154584589					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178364	49178414	51651994	51652044	18572	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-17				AGAAGTGATAAGTAGACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40109234135159583					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178312	49178362	51651942	51651992	18573	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-18				GCCCTGCTTGACATTCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1137376761633759					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178548	49178598	51652178	51652228	18574	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-19				CTTCTGTTGAGCAGATAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28997500941290461					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178450	49178500	51652080	51652130	18575	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-2				GGGGAAATTTGTTACTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.300298303976386					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178482	49178532	51652112	51652162	18576	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-20				TTCAAAAGCTGGTTCCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01264099168091181					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178382	49178432	51652012	51652062	18577	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-21				CAAGGTTCCCTGCAGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13290947458636679					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178573	49178623	51652203	51652253	18578	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-22				CAGGTATCTGAAAATCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5120535216606914					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178270	49178320	51651900	51651950	18579	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-23				CAGGGAAAGCAGAAGCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34025931451878122					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178610	49178660	51652240	51652290	18580	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-24				GAAGTGGGGGTCAGAAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17085911141410851					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178471	49178521	51652101	51652151	18581	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-3				GGTCCAGATATTTCAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64723718546843534					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178429	49178479	51652059	51652109	18582	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-4				ATACCCTTTTCTCACCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15828136905971621					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178352	49178402	51651982	51652032	18583	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-5				TTATCACTTCTTGCTGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088478024829264257					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178216	49178266	51651846	51651896	18584	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-6				TTTTCAACCTCAGGCCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074356987521791415					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178143	49178193	51651773	51651823	18585	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-7				AGTAATTCCAGGCTCTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33211866632382381					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178326	49178376	51651956	51652006	18586	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-8				AAGCAGGGCTAACAGAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12960424770952661					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49178245	49178295	51651875	51651925	18587	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-15-9				AGGCTGCCATCGTGCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2753440913162799					MEX3C	chr18	51174549	51218333	427033				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181422	49181472	51655052	51655102	18588	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-1				CTCCCGACCTTCAGGCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029613668554606142					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181207	49181257	51654837	51654887	18589	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-10				ACACTAAACCAGCCCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38997146257190779					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181711	49181761	51655341	51655391	18590	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-11				TGGTTTGCACCCTGGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1088206392816797					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181012	49181062	51654642	51654692	18591	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-12				GTGGGGCGGGGGAATAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65701702220208769					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181615	49181665	51655245	51655295	18592	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-13				CTACCTGATTTACATATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1775620626694572					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181133	49181183	51654763	51654813	18593	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-14				GGGGTGAATGCATTAAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45423563215255019					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180860	49180910	51654490	51654540	18594	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-15				AGGAGGATGGGATACCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36930300656723858					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180902	49180952	51654532	51654582	18595	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-16				TCACAAACCCCTTCTAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40035883704006342					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180833	49180883	51654463	51654513	18596	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-17				CAGATGTTCCACTGATTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28125934468407082					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181322	49181372	51654952	51655002	18597	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-18				GTCACAATGGGGAGGCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85400898920100832					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181001	49181051	51654631	51654681	18598	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-19				TCCTTTGAAAAGTGGGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80697140123801714					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182145	49182195	51655775	51655825	18599	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-2				CATGGTAGATATGGTGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.315915802526277					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181836	49181886	51655466	51655516	18600	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-20				CATTCTCTCAGGCTGCCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.112359890577088					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181391	49181441	51655021	51655071	18601	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-21				TGTTTTGCCTGTACTGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67370729198142565					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181238	49181288	51654868	51654918	18602	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-22				CTTGCAGATCTCTCCAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17365658142869481					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181929	49181979	51655559	51655609	18603	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-23				AAATATGACTCACCTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71773723221585828					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181182	49181232	51654812	51654862	18604	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-24				GATTTATTCACAGTCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35634430342601331					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181225	49181275	51654855	51654905	18605	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-25				AGTGTGGGTTTTGCCTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0655572336344248					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181120	49181170	51654750	51654800	18606	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-26				CATTCACCCCAAGGTGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.044095303690719768					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182134	49182184	51655764	51655814	18607	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-27				ATATCTACCATGTGTCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22036859257618691					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181193	49181243	51654823	51654873	18608	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-28				AGTCTCCTGCGGCACCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42202695139378982					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181954	49182004	51655584	51655634	18609	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-29				ATAGCAGAGGTGGATTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17469827141124261					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181334	49181384	51654964	51655014	18610	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-3				GGTGTGCGGAGAGTCACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60157741980342994					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181034	49181084	51654664	51654714	18611	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-30				GCAAATGTTTGAGCAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43916663528048883					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180928	49180978	51654558	51654608	18612	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-31				GCTGTCACCCTGCCCAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72053744621592486					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180883	49180933	51654513	51654563	18613	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-32				GTGAGCATCCCACTTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1058705664324114					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182121	49182171	51655751	51655801	18614	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-33				GTCAGGGTGGGCTCTGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55272760739427074					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180977	49181027	51654607	51654657	18615	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-34				GGCAGCAAACTCCTTCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34482653653164808					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181088	49181138	51654718	51654768	18616	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-35				GGGGAGAGTCTGGTTAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92084891953447823					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181580	49181630	51655210	51655260	18617	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-36				AGCCCCAGGTCTACCATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1161929159499531					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181282	49181332	51654912	51654962	18618	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-37				GGCTGGAGGGAGATCCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50294180349699869					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181773	49181823	51655403	51655453	18619	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-38				AGGAGAACCCAGGACAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43111552670384651					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181519	49181569	51655149	51655199	18620	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-39				GGGAGCCAAGTCCAGCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01034115087314324					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181530	49181580	51655160	51655210	18621	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-4				TGCGAGAAGACCCTGCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38058830362955409					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181911	49181961	51655541	51655591	18622	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-40				TATTTGAAAATGCTGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25782659693065269					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181825	49181875	51655455	51655505	18623	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-41				TTTCCTGACTGCATTCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.078218198447228784					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181499	49181549	51655129	51655179	18624	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-42				TCCTTGGCCTGGCCATGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37278999548923769					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181726	49181776	51655356	51655406	18625	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-43				CCACATGGTCTTGGGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52531977394356344					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181967	49182017	51655597	51655647	18626	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-44				TGGAGTATTTTTCATAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28747030463455658					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181267	49181317	51654897	51654947	18627	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-45				GCCTTCTCCTTATTTCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28600367315116121					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181803	49181853	51655433	51655483	18628	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-46				AGGTGTGGGAAAGACACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16367728316305991					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181348	49181398	51654978	51655028	18629	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-47				AGGCAGCACAGCGGGGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1647975293473895					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182010	49182060	51655640	51655690	18630	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-48				GGGACAAATAAAGCTGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43999711371211209					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181756	49181806	51655386	51655436	18631	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-49				TAGAAAACAAGGCTGGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.165084728921734					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181656	49181706	51655286	51655336	18632	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-5				AGGCCCATATTCTAACAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48241306941355122					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180988	49181038	51654618	51654668	18633	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-50				TTTCAAAGGAGCCCTCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81738355380710892					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181368	49181418	51654998	51655048	18634	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-51				ATGAAAGCATCTGCAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27284794572728882					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181851	49181901	51655481	51655531	18635	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-52				TTTTAGGTTTTAACTCCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59779916324852778					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181941	49181991	51655571	51655621	18636	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-53				ATTGAGCTGGGCCCCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95419236728024026					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181990	49182040	51655620	51655670	18637	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-54				AGGGCTGAGAGGTGCTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.223152786468832					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182068	49182118	51655698	51655748	18638	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-55				CAGAAGATCCTTTCTCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.043546719202234338					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181437	49181487	51655067	51655117	18639	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-56				CAAATAGGAGGAGAGGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6616279926446369					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181594	49181644	51655224	51655274	18640	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-57				GGGCTGCAAGCAGAAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.069039614570872515					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181636	49181686	51655266	51655316	18641	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-58				AGCAGGGACACAAAGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39988491843777307					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180956	49181006	51654586	51654636	18642	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-59				TGGAGGAAGAAATAAGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49647312705642538					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181545	49181595	51655175	51655225	18643	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-6				TTCTCGCAGAGGGTGCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6070550122541406					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181742	49181792	51655372	51655422	18644	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-60				TGTTTTCTACTCTCTGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56567013020620571					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181050	49181100	51654680	51654730	18645	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-61				TTCCCCTTCACCTCCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51512322680421108					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181482	49181532	51655112	51655162	18646	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-62				CAAGGAGCAGAGGGGAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.6201501196516732					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180848	49180898	51654478	51654528	18647	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-63				TTGGCTGGGGTGAGGAGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4135092565904519					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49180941	49180991	51654571	51654621	18648	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-64				TTCCTCCACCTCCCCAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32167262018660508					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181862	49181912	51655492	51655542	18649	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-65				TAAAACCTAAAAATCAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77516515967300981					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181069	49181119	51654699	51654749	18650	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-66				GGAAGGAGGGGTTGGTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78463546869855993					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181471	49181521	51655101	51655151	18651	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-67				GGGGAGACAGGGGAAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.443630541479195					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181296	49181346	51654926	51654976	18652	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-68				AGGAAGAGAGAGAAGGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.478955612926053					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181560	49181610	51655190	51655240	18653	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-7				CGGCTTTGAAGCCTTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5248547386600555					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49182030	49182080	51655660	51655710	18654	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-8				GATAAGCCAGTGCTTACTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92879294856050487					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49181691	49181741	51655321	51655371	18655	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-16-9				TTCGCTATGCAGATACTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48862918824692692					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183444	49183494	51657074	51657124	18656	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-1				AAGGGTTGATACCTGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01315148920087676					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183459	49183509	51657089	51657139	18657	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-10				GCCAAACCAAACACCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12669949573607081					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183604	49183654	51657234	51657284	18658	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-11				AACAGTCCTGCCATTGTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44554647509964262					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183621	49183671	51657251	51657301	18659	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-12				ACTTGGAAGCAATTAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69479703412979865					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183510	49183560	51657140	51657190	18660	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-13				TCAGTCAACATCTGTAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17527310803402479					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183107	49183157	51656737	51656787	18661	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-14				TGAAGCACATAATGCATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37129536392974238					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183582	49183632	51657212	51657262	18662	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-15				TATTTCCAGATCTTCCATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3257752516868398					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183280	49183330	51656910	51656960	18663	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-16				TTTGTACGCAGAAACACATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61341385786346647					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183354	49183404	51656984	51657034	18664	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-17				CTGAAACAATGGGATTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.221187712395554					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183639	49183689	51657269	51657319	18665	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-18				AAAGGAATTTCCTTTAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73676455340933988					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183379	49183429	51657009	51657059	18666	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-19				AGGTTATGGATCTCAGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83160251940876651					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183163	49183213	51656793	51656843	18667	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-2				TCAAGATATGGGTTATCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063621011648151385					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183317	49183367	51656947	51656997	18668	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-20				GTGAGACATTTGTCATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0029137088972432971					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183152	49183202	51656782	51656832	18669	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-21				TTCTCCTAATTTCAAGATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53396776911234611					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183081	49183131	51656711	51656761	18670	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-22				GACAACACAAATGAACTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14191880158301359					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183293	49183343	51656923	51656973	18671	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-23				ACACATAAGGAATGTGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34722877783746509					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183228	49183278	51656858	51656908	18672	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-24				TAAGTCAGAAAACTATCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.113813162135489					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183541	49183591	51657171	51657221	18673	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-25				CTCAAATTCTGATTTGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049911606710385858					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183136	49183186	51656766	51656816	18674	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-26				AGGAGAATAATGACAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.090789963096009188					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183330	49183380	51656960	51657010	18675	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-27				CATGCTGTGGAGAAAGAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34845568600385007					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183343	49183393	51656973	51657023	18676	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-28				AAGAGCAGGGTCTGAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039824803651088168					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183481	49183531	51657111	51657161	18677	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-29				AAAATTAATAAATTATATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27036175120801831					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183216	49183266	51656846	51656896	18678	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-3				CTATCTTTTGGGTAGGACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.047781977774852					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183568	49183618	51657198	51657248	18679	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-30				TTTTTTTTTTTTTTCCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515752					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183425	49183475	51657055	51657105	18680	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-4				GATTGCAAATTGGCTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34147080535203012					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183198	49183248	51656828	51656878	18681	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-5				ATTGGACTAAGTAACTTCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21868553776773789					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183399	49183449	51657029	51657079	18682	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-6				GCTTTAAATGCTCTCATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.815673573210741					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183047	49183097	51656677	51656727	18683	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-7				ACTCACAGTATTGTTATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51870959853811915					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183652	49183702	51657282	51657332	18684	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-8				TTAGATCTGGGATAAGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0195154851678569					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49183241	49183291	51656871	51656921	18685	hg38	N/A	enh69467	N/A	Enhatls83791	enhancer	SMAD4e-17-9				TTCTGACTTAGCAAAAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34264331407419418					MEX3C	chr18	51174549	51218333	434269				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185207	49185257	51658837	51658887	18686	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18				GAGATAAAGTTCTGAGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37452188636312728					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185032	49185082	51658662	51658712	18687	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-1				GCCTTTGATTGTGGGTCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37181178050100672					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184796	49184846	51658426	51658476	18688	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-10				TATACATGTGGGTAATTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30883125884397927					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185133	49185183	51658763	51658813	18689	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-11				ATGTTAGCTGCAGCATTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.020421315798252					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185060	49185110	51658690	51658740	18690	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-12				GTGGATACTGAAATTCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.076750069184400388					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185094	49185144	51658724	51658774	18691	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-13				TCAAAACCCTGCATTGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32963514756077877					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185287	49185337	51658917	51658967	18692	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-14				TTCTTCAAGACAGTTTACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16031751706418229					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184922	49184972	51658552	51658602	18693	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-15				CAGGTGAATTTCTTATCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0307782804327441					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184957	49185007	51658587	51658637	18694	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-16				AATGGGGATTAGGCACAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15203341072411941					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185362	49185412	51658992	51659042	18695	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-17				CGTTTCTGAGCAGGTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41315547326633623					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185260	49185310	51658890	51658940	18696	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-18				AGGAGCAAGTGTTTCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.166424696370781					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185016	49185066	51658646	51658696	18697	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-19				ATCACAGCAAATGCTTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32719989879095618					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184849	49184899	51658479	51658529	18698	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-2				TACTGTCACAAGGAGCCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02184155467583539					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185106	49185156	51658736	51658786	18699	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-22				ATTGTGACTGGCTGTTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.041377423645897471					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185189	49185239	51658819	51658869	18700	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-23				TCAGGCTTAAAAGCAAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1359725002945332					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184822	49184872	51658452	51658502	18701	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-24				TGAAAACAGTGCTTTTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081663789899487083					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184785	49184835	51658415	51658465	18702	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-25				AAATTCAACAATATACATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35245482247112908					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184904	49184954	51658534	51658584	18703	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-26				TCTGGTGGGAAGAGGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.2647263743371786					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185379	49185429	51659009	51659059	18704	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-3				GAAACGCTTGCTCCTTGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71139202834888049					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184983	49185033	51658613	51658663	18705	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-4				CAGACATTTCGATTAATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1078222720466156					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185345	49185395	51658975	51659025	18706	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-5				CCCTAGCAGAGTGATGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070668187730500223					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185233	49185283	51658863	51658913	18707	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-6				CAGGGACAGCACTCTGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18340814894934179					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49185398	49185448	51659028	51659078	18708	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-7				ATCTTCTAGAGAGTTCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.030554962442691389					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184864	49184914	51658494	51658544	18709	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-8				CCGAATGGAGAAAGTCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62022524128947432					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49184945	49184995	51658575	51658625	18710	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-18-9				TAATCCCCATTCTCAAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.130212940224918					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186325	49186375	51659955	51660005	18711	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-1				AAGGATTAAGAGCGACCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.15462459713029					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186099	49186149	51659729	51659779	18712	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-10				CAGGGCAAACGCCTGAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040674884691275441					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186416	49186466	51660046	51660096	18713	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-11				AGAACTGCTTGCTTCAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45080726967822909					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186156	49186206	51659786	51659836	18714	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-12				ACTACATACCTGCCTTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0413665746854259					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186232	49186282	51659862	51659912	18715	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-13				AGCTATCAAAGTTTGCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057314268387373191					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186290	49186340	51659920	51659970	18716	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-14				GTGGCTGGTAGGCTTTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4787393570184999					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186482	49186532	51660112	51660162	18717	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-15				AGTGGTCTTGCAAAAGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29790056225888889					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186186	49186236	51659816	51659866	18718	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-16				GATTTTGCATCAGAGAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07871718753503229					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186129	49186179	51659759	51659809	18719	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-17				CACTGCTTCAGTGACACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21054864828169939					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186439	49186489	51660069	51660119	18720	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-18				CATCAGTGTGATGTTTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03332933092523882					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186543	49186593	51660173	51660223	18721	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-19				GAGAAATGCAGCATTAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94394065522187509					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186278	49186328	51659908	51659958	18722	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-2				CTACCAGCCACTTAGCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0829229186217936					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186529	49186579	51660159	51660209	18723	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-20				TAATGAAGGGATGTGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0074062239219633					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186500	49186550	51660130	51660180	18724	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-21				GCTCAAGGTAGCTGAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.139059276305412					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186471	49186521	51660101	51660151	18725	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-22				AAAAGGTTTTGGCAACAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02217528560533288					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186515	49186565	51660145	51660195	18726	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-23				GCTCAGTGGGAAGAGGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062373022860306868					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186375	49186425	51660005	51660055	18727	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-24				GGAGGCAGGGAGCACATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22934553011279821					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186577	49186627	51660207	51660257	18728	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-25				GATGAAGAAAGCAGGGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.245402054445794					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186364	49186414	51659994	51660044	18729	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-26				GCACATGGCAGGGGAGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7953688095185241					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186172	49186222	51659802	51659852	18730	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-3				TGCAAAATCACTGCTCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17056581713069791					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186110	49186160	51659740	51659790	18731	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-4				AGTGTGCTGTACCTATGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10774575831865769					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186248	49186298	51659878	51659928	18732	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-5				GATAGCTTCTACAAGCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2324389991680269					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186309	49186359	51659939	51659989	18733	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-6				TAGGATTTAAAGGTCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4021609927451531					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186398	49186448	51660028	51660078	18734	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-7				GTTCTTGACAAGGCAGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26799353924975361					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186145	49186195	51659775	51659825	18735	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-8				CAGGTATGTAGTAGCACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50570448710934723					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78105	chr18	49186344	49186394	51659974	51660024	18736	hg38	N/A	N/A	N/A	Enhatls83791	enhancer	SMAD4e-19-9				AGGCATATGCTCTATCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1135893799679336					MEX3C	chr18	51174549	51218333	439273				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2123
enhrx-78099	chr18	48691150	48691200	51164780	51164830	18737	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-1				GCCTATGTTGGTGTGCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1079401647863741					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691138	48691188	51164768	51164818	18738	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-10				TTGTAATAGCTAGCCTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28451903416637558					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691574	48691624	51165204	51165254	18739	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-11				AGGGTGATGACTTTCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18010545106453341					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691323	48691373	51164953	51165003	18740	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-12				GGGAAGGACCCAGCTAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0674558406084911					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691212	48691262	51164842	51164892	18741	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-13				TGTGTGCCCTTGGCACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13519153235965881					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691123	48691173	51164753	51164803	18742	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-14				TATTACAAACCCCAAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23670329230271969					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691637	48691687	51165267	51165317	18743	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-15				GGTCAAGCTGCTCTCTGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10556561801525161					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691287	48691337	51164917	51164967	18744	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-16				TCCCCTGGGGTTTAGGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39789704266222348					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691436	48691486	51165066	51165116	18745	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-17				CTGGATGGCAATGAGAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73129592596502091					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691089	48691139	51164719	51164769	18746	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-18				GTTCCAGCTGTCTTTGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63000726524149231					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691403	48691453	51165033	51165083	18747	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-19				ATGTTAGTGGGAGGGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.290722973663893					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691105	48691155	51164735	51164785	18748	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-2				CTGGAACAAATTGCATCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13073001156664191					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691560	48691610	51165190	51165240	18749	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-20				CTGCCAGGGCCAACTGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093000395868617608					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691490	48691540	51165120	51165170	18750	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-21				CACTTCCTGAGGATCCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30939529157232609					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691227	48691277	51164857	51164907	18751	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-22				GGCACACAAAGCTGCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084545608592416013					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691479	48691529	51165109	51165159	18752	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-23				GGGGGTGGAAGCACTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1016911891081361					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691594	48691644	51165224	51165274	18753	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-24				GATGGAGTGCTGGCAAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091130763896069361					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691299	48691349	51164929	51164979	18754	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-25				ACCCCAGGGGAGAGCTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5639086763840151					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691242	48691292	51164872	51164922	18755	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-26				CTGATTGAATTCCTTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14035652899845841					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691547	48691597	51165177	51165227	18756	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-27				CTGGACCTGGCCAAGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26503606772428517					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691536	48691586	51165166	51165216	18757	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-28				CAAGCAGGCAGGCGGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41201715263305971					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691417	48691467	51165047	51165097	18758	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-29				GAACAATGGAAGAGGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1511088908478071					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691658	48691708	51165288	51165338	18759	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-3				GGACCCTCCTGTCAAGTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22788848889081309					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691199	48691249	51164829	51164879	18760	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-30				CACAAAATGGGAAAGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.025475283227838					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691454	48691504	51165084	51165134	18761	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-31				CTCATCCCCAGGCCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8386243683823582					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691353	48691403	51164983	51165033	18762	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-32				GGGGAAACAGACACATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14207211278416959					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691465	48691515	51165095	51165145	18763	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-33				TCCACCCCCTCCTCATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98703760330224788					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691078	48691128	51164708	51164758	18764	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-4				CTTTGGCATGGGCTCTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1130889162327304					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691391	48691441	51165021	51165071	18765	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-5				CCCAACTGATGAATGTTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0606495808112903					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691373	48691423	51165003	51165053	18766	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-6				TTGGGCCCAGCATTCTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18974530065758169					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691616	48691666	51165246	51165296	18767	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-7				CCTTGGCTATAAGTCTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32111198091820181					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691513	48691563	51165143	51165193	18768	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-8				AGGTGGCGGCTGAAAACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068848263804562257					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48691173	48691223	51164803	51164853	18769	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-2-9				GGTTTAAAATAGCATACAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0110294666004442					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78107	chr18	49511047	49511097	51984677	51984727	18770	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-1				TGTGAGAATCTTGGCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52608391526696008					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511129	49511179	51984759	51984809	18771	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-10				TCAGAGCAGGAGCAAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080423126648256751					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511341	49511391	51984971	51985021	18772	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-11				TATTAGAAGGTGATATGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.066354328031478					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511116	49511166	51984746	51984796	18773	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-12				AGGTCTTACATGGTCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10180359530928					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511070	49511120	51984700	51984750	18774	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-13				AAGTGATTGAAAGTTTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76473512896841822					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511181	49511231	51984811	51984861	18775	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-14				GAGTGAGTTATCTTGAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33420626528707542					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511287	49511337	51984917	51984967	18776	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-15				CAAATTGTAATTTCCAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1083616330979497					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511261	49511311	51984891	51984941	18777	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-16				TGGACCTGGTGGGAGGTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28898920734623451					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511300	49511350	51984930	51984980	18778	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-17				TTACAATTTGACATAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.514598558503534					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511354	49511404	51984984	51985034	18779	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-2				CACTTTCGTTTTATATTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46831739701383462					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511036	49511086	51984666	51984716	18780	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-3				AAGATTCTCACACAGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19844899589922621					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511239	49511289	51984869	51984919	18781	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-4				GATCATGGGGACAGTTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0799691446539541					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511083	49511133	51984713	51984763	18782	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-5				TCAATCACTTCTGAAGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31465356214648432					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511203	49511253	51984833	51984883	18783	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-6				CTCACCATGACAACACCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15542576554741211					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511096	49511146	51984726	51984776	18784	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-7				AAGGCAAAGGGGAAGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.755110094599285					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511275	49511325	51984905	51984955	18785	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-8				TCCAATGTTGGAGGTGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14125787858329511					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49511218	49511268	51984848	51984898	18786	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-20-9				GGGATTAACACCATCCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26461601806170659					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514768	49514818	51988398	51988448	18787	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-1				GCTAATAAGCTTCGATCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.175634495279414					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514757	49514807	51988387	51988437	18788	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-10				AAGCTTATTAGCACTTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42563820148771692					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49515031	49515081	51988661	51988711	18789	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-11				AGAATCTGCAGGCCAAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.136838409322911					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514825	49514875	51988455	51988505	18790	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-12				GTGCTGTTTTTCCTGTTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0490065261909787					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49515002	49515052	51988632	51988682	18791	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-13				ATTATTTTAGCAGAGGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41673868159333238					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49515020	49515070	51988650	51988700	18792	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-14				ATAATGTTTAAAGAATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65671205202839256					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49515043	49515093	51988673	51988723	18793	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-15				TGCTTGCTGAGACCTGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5708987992053135					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514900	49514950	51988530	51988580	18794	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-16				GACCAAAGAAGGGGGAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75217296569244441					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514944	49514994	51988574	51988624	18795	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-17				TCATTTAACCTCTCAGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73578022817063771					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514991	49515041	51988621	51988671	18796	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-18				AGAGGCCAGAGGTGAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091313480381813555					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514933	49514983	51988563	51988613	18797	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-19				GAGGTTAAATGACTTGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32836356878552192					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514780	49514830	51988410	51988460	18798	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-2				CGATCTCCAGGCTGTAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4723447374865799					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514836	49514886	51988466	51988516	18799	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-3				ACTTTAGAAGACCTCATAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2969774563496711					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514801	49514851	51988431	51988481	18800	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-4				GGGCTGCGGAGGCTCTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96088189294998738					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514962	49515012	51988592	51988642	18801	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-5				ATTTGCAGGTGAAGACTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28295667180895828					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514976	49515026	51988606	51988656	18802	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-6				AGAGAGGGAGCCTAATTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16863193218260389					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514917	49514967	51988547	51988597	18803	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-7				TTGGTCTCTGTGGGAACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31943758035691988					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514859	49514909	51988489	51988539	18804	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-8				GGCTGAATAGAGCCCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6338968249485348					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49514872	49514922	51988502	51988552	18805	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-21-9				GATTCAAATTTTTCCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36437725475093141					DCC	chr18	52340196	53535899	341022				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587498	49587548	52061128	52061178	18806	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-1				GTGTGCCCTTCCTATTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45690184694837449					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587152	49587202	52060782	52060832	18807	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-10				GAAACAATGGGGCAGGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15963116674933739					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587252	49587302	52060882	52060932	18808	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-11				TAGTCTGAGCATTCTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1335401783405146					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587475	49587525	52061105	52061155	18809	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-12				AAACCAGGATCTCATTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.076290493389634922					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587459	49587509	52061089	52061139	18810	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-13				CTGAAGGCTCCTGCCTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.024969444989381442					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587174	49587224	52060804	52060854	18811	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-14				GTTTGACATTAGGGGAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14405427352290459					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587292	49587342	52060922	52060972	18812	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-15				CTGCTCCTTTCCTAAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.098043891014509971					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587128	49587178	52060758	52060808	18813	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-16				TCTGACAGAGCACACAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.212250598389703					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587437	49587487	52061067	52061117	18814	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-17				GCTGCAGGTGAAGGCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068672604520305311					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587163	49587213	52060793	52060843	18815	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-18				GGGGAATGAAGGAAACAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.261503112959502					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587233	49587283	52060863	52060913	18816	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-19				TGGGGAACAAACAGAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34499002134996071					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587281	49587331	52060911	52060961	18817	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-2				GGAAAGGAGCAGTCTCGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5522997120467108					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587220	49587270	52060850	52060900	18818	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-20				GAAAAGAAGGTAGGGAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.021792804755583869					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587413	49587463	52061043	52061093	18819	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-3				AATATTCGCACAAAGTGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.093883276039311875					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587398	49587448	52061028	52061078	18820	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-4				CGAATATTAGCATCTGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0040515449035399172					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587306	49587356	52060936	52060986	18821	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-5				AAGATTTGGATTTGCTAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29161532685271141					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587192	49587242	52060822	52060872	18822	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-6				CAAACCCTAACCAAATACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036833329592820083					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587317	49587367	52060947	52060997	18823	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-7				TTGCTAGCAAGGGAACTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30271657181479089					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587374	49587424	52061004	52061054	18824	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-8				CTCAGGGGGCCTTGCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13569231240472229					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49587360	49587410	52060990	52061040	18825	hg38	N/A	enh69468	N/A	Enhatls83793	enhancer	SMAD4e-22-9				ACAGCTTTAAGTCCCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45504272812269891					DCC	chr18	52340196	53535899	277163				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627976	49628026	52101606	52101656	18826	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-1				AAACCTGAGAGGTCTCGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64368331138404022					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49628017	49628067	52101647	52101697	18827	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-10				GCAAGCTACAGCAATAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12152478807800431					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49628051	49628101	52101681	52101731	18828	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-11				CTATGAACAAATATAGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20173018550780031					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627857	49627907	52101487	52101537	18829	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-12				CTCAGATTTCTTTGAAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29729588713642058					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627806	49627856	52101436	52101486	18830	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-13				AGTGTCTGGAAAGTAGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46838989577957407					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627820	49627870	52101450	52101500	18831	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-14				GCTGGAGCAGAGCAAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05843319960228055					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627927	49627977	52101557	52101607	18832	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-15				GTTTTGAAGATAGAGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1170822568182099					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627952	49628002	52101582	52101632	18833	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-16				GGTGAGAAGTGGTTGCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.775290160069971					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627838	49627888	52101468	52101518	18834	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-2				TAGGATTGTATCAATTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19254695861269941					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627721	49627771	52101351	52101401	18835	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-3				AACTGCTGGTTGGACAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080229377690181708					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627900	49627950	52101530	52101580	18836	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-4				CTCCCTATGTCTGAACTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.088445153271211358					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627735	49627785	52101365	52101415	18837	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-5				TGGAGATATTAACTAACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039684885981287353					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627987	49628037	52101617	52101667	18838	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-6				TGGAAGTGTTGAAACCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3336723607296711					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627772	49627822	52101402	52101452	18839	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-7				AGACATCTCACACTCAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38221735310468569					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627755	49627805	52101385	52101435	18840	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-8				ATGTCTACTAGACACACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55836355368082835					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49627963	49628013	52101593	52101643	18841	hg38	N/A	N/A	N/A	Enhatls83793	enhancer	SMAD4e-23-9				CTCGGTAGGGTGGTGAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.452528621245917					DCC	chr18	52340196	53535899	223442				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687175	49687225	52160805	52160855	18842	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-1				GTCATACACTGCTAGCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41883878142394348					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687226	49687276	52160856	52160906	18843	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-10				GCTATGAATCTTATGTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.135562131369221					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687324	49687374	52160954	52161004	18844	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-11				GAGTACCCTGGAGCTGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24552032632394141					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687196	49687246	52160826	52160876	18845	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-12				GGTAAAAAGACTGTGAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28291504767218378					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687045	49687095	52160675	52160725	18846	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-13				TTCATTTGCAGCTATGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57047870655406763					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687078	49687128	52160708	52160758	18847	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-14				ACTTTGTTCTTCAAAGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1286763534620734					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687427	49687477	52161057	52161107	18848	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-15				CTTAAAACAGGTGAATTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69377189534495587					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687131	49687181	52160761	52160811	18849	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-2				GTCAATGCTGATTAGCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02182128479696022					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687032	49687082	52160662	52160712	18850	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-3				ATGAAGTAGGGCTTTACTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46625061941210649					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687336	49687386	52160966	52161016	18851	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-4				TCAATTGACACTGAGTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68990390271900925					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687146	49687196	52160776	52160826	18852	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-5				TGACTCATTCACTCGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070060352195599043					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687269	49687319	52160899	52160949	18853	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-6				AGGCTGCTACTTTCTTAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6152435048422451					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49686975	49687025	52160605	52160655	18854	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-7				GGTACCTAAACACCAAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16842691563147719					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49687289	49687339	52160919	52160969	18855	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-8				TGAAGCAATGCAGCTGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1552026292704129					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78107	chr18	49686998	49687048	52160628	52160678	18856	hg38	N/A	enh58822	N/A	Enhatls83794	enhancer	SMAD4e-24-9				ACTTTGACAGAATATTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51378294460319385					DCC	chr18	52340196	53535899	177115				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2125
enhrx-78109	chr18	49965882	49965932	52439512	52439562	18857	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-1				GCGCTTCAGTATCTTATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33210313856625828					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965750	49965800	52439380	52439430	18858	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-10				CCTGACTCCCTAATTTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44166381400751359					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965916	49965966	52439546	52439596	18859	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-11				GTATGAAAGGATTGAGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18514224625096509					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965903	49965953	52439533	52439583	18860	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-12				GCCCTGTTAAAAAGTATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5793634658263912					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49966038	49966088	52439668	52439718	18861	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-13				CTGTTGAAGGATCCTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1248439414491139					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965763	49965813	52439393	52439443	18862	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-14				TTTCTTATGGCTTCACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42449301817000429					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965780	49965830	52439410	52439460	18863	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-15				CTCTGGTTTGTATATATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0460567427873351					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965720	49965770	52439350	52439400	18864	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-16				ATTAGCTGTAGTTTCACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52788461477739379					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965835	49965885	52439465	52439515	18865	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-17				CACAGAGGCAAGGTCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62742394977206906					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965928	49965978	52439558	52439608	18866	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-18				TGAGGTTGTGGGAGAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8795854420315807					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965850	49965900	52439480	52439530	18867	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-19				TGAGGGAACTGGGAGCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.170493468437087					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965952	49966002	52439582	52439632	18868	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-2				GTTGACATTTTATGATAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0278802721757589					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49966022	49966072	52439652	52439702	18869	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-3				TCCTAGGTCATGTCCCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057407410114277482					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965692	49965742	52439322	52439372	18870	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-4				AAGTATACTACCCACACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32923921118652472					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965861	49965911	52439491	52439541	18871	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-5				GGAGTTACTAATGAGGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0757963389405127					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49966009	49966059	52439639	52439689	18872	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-6				GTTAAATAGCAGACCTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13959372438941181					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965814	49965864	52439444	52439494	18873	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-7				GGTCCAGATGCCTCACCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1039749828166486					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965799	49965849	52439429	52439479	18874	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-8				TAGGGTGAGAAATGGCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13488257172152129					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49965703	49965753	52439333	52439383	18875	hg38	N/A	enh75996	N/A	Enhatls83796	enhancer	SMAD4e-25-9				GCTAATGTGTTCCTGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1238411697550944					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973567	49973617	52447197	52447247	18876	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-1				GTATTATCGACTAAGACGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073576116873003333					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973594	49973644	52447224	52447274	18877	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-10				ACTCTGCTAACCATTTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39228184549459461					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973832	49973882	52447462	52447512	18878	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-11				GTGTGACTGACCTTGGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0386977090542806					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973802	49973852	52447432	52447482	18879	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-12				ACTATACAGGTTGAGAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1751681275336528					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973481	49973531	52447111	52447161	18880	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-13				TTTCTTACAGATAAGACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24044116932220319					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973518	49973568	52447148	52447198	18881	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-14				TTTCTTGTTTTGAAACCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35185914710524008					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973735	49973785	52447365	52447415	18882	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-15				TAAAGTATTACTGTAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.88203171890041					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973461	49973511	52447091	52447141	18883	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-16				AAATATTGTGTTTTCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078510159464054138					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973503	49973553	52447133	52447183	18884	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-2				GCACATCTTAGTCTGCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36844503700290482					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973789	49973839	52447419	52447469	18885	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-3				GCAGATGACAGTTACTATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36407926281342962					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973644	49973694	52447274	52447324	18886	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-4				TCCCTCACTATCTTTAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61390863549165542					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973549	49973599	52447179	52447229	18887	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-5				GGGGGTTATCTTTATCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0974975563493722					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973702	49973752	52447332	52447382	18888	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-6				ATCATCATAGTTGGGAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070677776062356562					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973775	49973825	52447405	52447455	18889	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-7				GTCATCTGCCACTGCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30274624662246469					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973867	49973917	52447497	52447547	18890	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-8				AGAGGGAGATGCTACTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51421091324490953					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49973850	49973900	52447480	52447530	18891	hg38	N/A	N/A	N/A	Enhatls83796	enhancer	SMAD4e-26-9				ACTGGAACAGGCTTCACAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.495461303770269					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978218	49978268	52451848	52451898	18892	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-1				GCAGCTAGGCATTACCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44193971619079581					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978382	49978432	52452012	52452062	18893	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-10				ATTCAGAGCAGGTAAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32633444637715908					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978256	49978306	52451886	52451936	18894	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-11				CAGAAGTTCAAACTAAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21581014571754481					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978393	49978443	52452023	52452073	18895	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-12				GAAAAGGACTGATTCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3087531535063166					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978478	49978528	52452108	52452158	18896	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-13				TGTCTGCAGCTTCTGCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10337069115417211					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978232	49978282	52451862	52451912	18897	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-14				CTAGAGAGAAGAGCCCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46410095726918382					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978409	49978459	52452039	52452089	18898	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-15				CTGCAAACTGGGGCAGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.952739919330717					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978314	49978364	52451944	52451994	18899	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-16				AAAAATCACATTATCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.115428772615311					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978347	49978397	52451977	52452027	18900	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-17				TGTTCACACTGGCAATGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18882431664588609					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978275	49978325	52451905	52451955	18901	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-18				TCTGCTTCTGTCTTCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29056398270134282					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978463	49978513	52452093	52452143	18902	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-2				CTTAGTGGATTATCAGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058865515087333328					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978204	49978254	52451834	52451884	18903	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-3				TCTGATCCCTTGTTGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26598997451528239					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978440	49978490	52452070	52452120	18904	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-4				AGTGAGTGGCTTTGGTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049754740812679138					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978165	49978215	52451795	52451845	18905	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-5				GATACATAAACCAAGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23127383339255719					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978336	49978386	52451966	52452016	18906	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-6				TCCAGCTCATCTGTTCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76975159747363908					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978507	49978557	52452137	52452187	18907	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-7				TTTCACAAGGACTCAACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17411288925680751					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978420	49978470	52452050	52452100	18908	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-8				ACTCCCTCTATCTGCAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.115298284763696					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78109	chr18	49978494	49978544	52452124	52452174	18909	hg38	N/A	enh75997	N/A	Enhatls83796	enhancer	SMAD4e-27-9				GCAGACAAGCTGTTTTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.098363236449480848					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2127
enhrx-78110	chr18	50208946	50208996	52682576	52682626	18910	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-1				GCTTGGCGTTTAGTGAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.165752500112823					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208779	50208829	52682409	52682459	18911	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-10				ATTCCAGGCTTAGGAACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0429659212414729					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208746	50208796	52682376	52682426	18912	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-11				GCAATACTTAGAGAAGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44894246011928629					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208824	50208874	52682454	52682504	18913	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-12				ACTATTCTTCTTCACGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.279961135301293					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50209009	50209059	52682639	52682689	18914	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-13				AAGCCAGTGATGTCCTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1087166014804946					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208910	50208960	52682540	52682590	18915	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-14				TAGATCATGCAGAGCATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.991151367908724					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50209022	50209072	52682652	52682702	18916	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-15				TGTTAATTATCTGCCTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.09581316747825297					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208850	50208900	52682480	52682530	18917	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-16				TTGGTGGCTCTTGGTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.371210571198553					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208764	50208814	52682394	52682444	18918	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-17				TTTGGAGGAAAATGCATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0325258628925657					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50209051	50209101	52682681	52682731	18919	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-18				AGACAAATATAAAATATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.8312929380298759					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50209094	50209144	52682724	52682774	18920	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-19				AAAACAAAACAGACAGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21421457649329459					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208959	50209009	52682589	52682639	18921	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-2				AACGCCAAGCATCTGCTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31916361497870421					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208884	50208934	52682514	52682564	18922	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-20				ATGAGGCTGGAGAGGCGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96534037842901566					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208714	50208764	52682344	52682394	18923	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-3				GGATAAAACATGCACTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7380823591664909					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208869	50208919	52682499	52682549	18924	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-4				AGCCTCATCTCACAAGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0541195947384125					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208638	50208688	52682268	52682318	18925	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-5				GGTCTGTAGAGTAAAGGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32678064059836381					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208970	50209020	52682600	52682650	18926	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-6				TCTGCTATGAGGTGCTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063589570772849865					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208692	50208742	52682322	52682372	18927	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-7				CAACGAGAAAAATATCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.021204465332869009					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208661	50208711	52682291	52682341	18928	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-8				AGGTACTACTGATACAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14322804103395051					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78110	chr18	50208813	50208863	52682443	52682493	18929	hg38	N/A	enh69472	N/A	Enhatls83797	enhancer	SMAD4e-28-9				TCACGTTCCTGGAATGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63128779229207421					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2128
enhrx-78111	chr18	50414579	50414629	52888209	52888259	18930	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-1				CTATACAACTTCCTGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36607232766690712					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414723	50414773	52888353	52888403	18931	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-10				GATAGGATTTCTTTTTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48592635363924908					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414517	50414567	52888147	52888197	18932	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-11				TTCAAACAGGAAGCACAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3486996213988488					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414652	50414702	52888282	52888332	18933	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-12				TTGTTAATACAGAAATCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.727486763834716					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414673	50414723	52888303	52888353	18934	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-13				AACAAGGACAAAACAGTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0198933201659619					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414381	50414431	52888011	52888061	18935	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-14				CTTCATTTATTAAGTGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8841295902959541					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414530	50414580	52888160	52888210	18936	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-15				ATTTAATTAGCTTTTCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4472911991521009					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414417	50414467	52888047	52888097	18937	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-16				TAATTCTTTGTGATATAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.4677979332082369					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414706	50414756	52888336	52888386	18938	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-17				GGATAATACAATTTAAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414772	50414822	52888402	52888452	18939	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-2				TCAGCTTGGTGTGAATAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42643123865796517					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414594	50414644	52888224	52888274	18940	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-3				GCTGCAGGCCATTAACACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47870286214976371					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414548	50414598	52888178	52888228	18941	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-4				TAAATGGTCTCATTGCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.011401854173534721					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414612	50414662	52888242	52888292	18942	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-5				TTTTGTCAGCACTTCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0026334845002648					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414685	50414735	52888315	52888365	18943	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-6				ACAGTATGTGGTCTTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3236941415852041					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414758	50414808	52888388	52888438	18944	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-7				TGAAAATTAGCAGTTCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53829451886794888					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414451	50414501	52888081	52888131	18945	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-8				TCAATCACCAATTAAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65247138386337555					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78111	chr18	50414739	50414789	52888369	52888419	18946	hg38	N/A	enh76010	N/A	Enhatls83799	enhancer	SMAD4e-29-9				TTCAGAGACAAATGCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0189548047077052					DCC	chr18	52340196	53535899	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2129
enhrx-78099	chr18	48695082	48695132	51168712	51168762	18947	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-1				AGGCTTACAAGTGTCGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1871790800158995					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694584	48694634	51168214	51168264	18948	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-10				GCATGTTCTTCACCCCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0951487120496033					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694820	48694870	51168450	51168500	18949	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-11				GTTTGGCTTTCAATGTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38452758720593161					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694187	48694237	51167817	51167867	18950	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-12				TCCTATTTGACCCTTGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26801861522665					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694427	48694477	51168057	51168107	18951	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-13				TGACTGTAAAGCAGGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22251334094665881					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694475	48694525	51168105	51168155	18952	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-14				CAAGATCTCTAGAGAAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4657535712080576					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694511	48694561	51168141	51168191	18953	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-15				CAGCTTTGTAAAGGGGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.866461056929138					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694968	48695018	51168598	51168648	18954	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-16				GGGGTGAATAATTTGTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62245600174127635					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694633	48694683	51168263	51168313	18955	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-17				TTGTCTCATTGTGTAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51776932419330735					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694442	48694492	51168072	51168122	18956	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-18				GCCAGACCACTGTGTCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049483725000098469					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694322	48694372	51167952	51168002	18957	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-19				GGTGAAAGATAGGTTGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40988446407625623					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694544	48694594	51168174	51168224	18958	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-2				CCCGACTGTGGCATTTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055181535220351213					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694232	48694282	51167862	51167912	18959	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-20				TAGGATGCCTGCACTTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31322867259416071					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48695021	48695071	51168651	51168701	18960	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-21				TCAACTTCTCCCTTTAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022457404393597891					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694415	48694465	51168045	51168095	18961	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-22				CTTTACAGTCACCCAGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.18119494681678					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694711	48694761	51168341	51168391	18962	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-23				CTTAATCCTTAAACTCTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4125186579984961					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694403	48694453	51168033	51168083	18963	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-24				AAGTGCAGCAGGCCCGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.586452938794239					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694657	48694707	51168287	51168337	18964	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-25				AAGTTCATTCATCTCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3408726298650725					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694596	48694646	51168226	51168276	18965	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-26				GAAGAACATGCACATCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24715333542482459					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694279	48694329	51167909	51167959	18966	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-27				AAGCCTAAGAAAATGGATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42434610247081678					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694364	48694414	51167994	51168044	18967	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-28				TTGATGGGGCTGCTGGTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1069531756013483					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694493	48694543	51168123	51168173	18968	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-29				AGCTGTCTCTTGCACTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54109040915580731					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48695047	48695097	51168677	51168727	18969	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-3				TAGCCCACCCATACAAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6531156260987911					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694832	48694882	51168462	51168512	18970	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-30				ATGTCAGAAGGCATTTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0083524967021919062					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694213	48694263	51167843	51167893	18971	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-31				TTGGAAGTCTCATTTTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12698321253910941					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694337	48694387	51167967	51168017	18972	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-32				CTTTCACCAAATAGATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.026328288307837559					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694571	48694621	51168201	51168251	18973	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-33				TGAGGAAGCAGCACCCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75049918383074621					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694619	48694669	51168249	51168299	18974	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-34				ATGAGACAAAGAATGGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13427420661367989					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694736	48694786	51168366	51168416	18975	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-35				TCATTGTATATGAAACATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.271155083661591					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694934	48694984	51168564	51168614	18976	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-36				GTAAACACCCCATAGTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3110483245001448					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694392	48694442	51168022	51168072	18977	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-37				TCTGAGGTGGGAAGTGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44128028763345722					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48695062	48695112	51168692	51168742	18978	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-38				AGGGGAGGTGGGTAGGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02884681700761697					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694251	48694301	51167881	51167931	18979	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-39				AAGATTTTATTTGAAAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69537032200468951					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694788	48694838	51168418	51168468	18980	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-4				AACTTGCTTAAGCCTTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1190779513922275					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694987	48695037	51168617	51168667	18981	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-40				TTAGTACTATTGACATTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8136894383111091					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694912	48694962	51168542	51168592	18982	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-41				TGGGTGGAGGCCAGGGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94617767810417763					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694892	48694942	51168522	51168572	18983	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-42				TGTGTACTACTGACATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16091133550697029					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694528	48694578	51168158	51168208	18984	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-5				AGTCGGGGTTCCTAAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14205233076594459					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694676	48694726	51168306	51168356	18985	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-6				ATGGGGCTCTCATCTGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52529344256500865					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694350	48694400	51167980	51168030	18986	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-7				GATTCTGAGGCAACTTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38583084096653181					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694380	48694430	51168010	51168060	18987	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-8				TAATAGGCACTGTCTGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13360432416903739					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78099	chr18	48694803	48694853	51168433	51168483	18988	hg38	N/A	enh69466	N/A	Enhatls83785	enhancer	SMAD4e-3-9				TGGACTGGCTAATGAGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069482677268761686					MEX3C	chr18	51174549	51218333	3005				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2117
enhrx-78100	chr18	48722060	48722110	51195690	51195740	18989	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-1				GTCGGATACAGAGGTACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73658545550758892					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722096	48722146	51195726	51195776	18990	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-10				CACCTTCACAAATCTACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12788113617464139					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722163	48722213	51195793	51195843	18991	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-11				TGTCTGCAGTACTGGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41202345374950822					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721933	48721983	51195563	51195613	18992	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-12				TTGCATGCCTCTTTACTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19155926554251651					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722111	48722161	51195741	51195791	18993	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-13				ACTCCTGGAATCTGAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.602436579254016					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722029	48722079	51195659	51195709	18994	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-14				GGAAGGTCCTAAGTTCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5602169686072911					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722266	48722316	51195896	51195946	18995	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-15				TTTAAAACTGTTCAGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33337476692471651					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722381	48722431	51196011	51196061	18996	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-16				GCTGTTGAGAAACTTAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095737624383491954					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721858	48721908	51195488	51195538	18997	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-17				ATGATCTCATCTTTCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077533640991505129					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722222	48722272	51195852	51195902	18998	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-18				AGGTAATTAAGAAACTTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1300090505954219					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722338	48722388	51195968	51196018	18999	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-19				AGAAATACAGTTAAGATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21756051533322621					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722316	48722366	51195946	51195996	19000	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-2				TCTCGGTACGTTTCAACTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47519765722867291					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721894	48721944	51195524	51195574	19001	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-20				GGTCAAATAAAGAGAGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.183913013333673					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722242	48722292	51195872	51195922	19002	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-21				TGAAGAAAAAATGGACACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0381866877120369					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722295	48722345	51195925	51195975	19003	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-22				GGAAAGACACACTGACACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2230826218837787					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722175	48722225	51195805	51195855	19004	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-23				TGGTGTGCTGGCAAGTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54752448828061739					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722077	48722127	51195707	51195757	19005	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-24				GGTGGGGGAAGGGGATGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.668884214424459					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721965	48722015	51195595	51195645	19006	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-3				TAAACCACATTGTCATGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.91315664976152289					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722349	48722399	51195979	51196029	19007	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-4				TAAGATAGGCGGCAGTGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48408248537994009					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721916	48721966	51195546	51195596	19008	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-5				GTTAGGTTGAGAGCATTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.235087370705792					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722046	48722096	51195676	51195726	19009	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-6				GTATCCGACATTTTTAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37254202823638921					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721843	48721893	51195473	51195523	19010	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-7				TATGTGTACTTTAGACCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62863773582626736					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48722133	48722183	51195763	51195813	19011	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-8				GTCCTTTGTCTGAACAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36421715977296859					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78100	chr18	48721998	48722048	51195628	51195678	19012	hg38	N/A	N/A	N/A	Enhatls83786	enhancer	SMAD4e-4-9				CATCTGCCCCTTTCATAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092274034712223424					MEX3C	chr18	51174549	51218333	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2118
enhrx-78101	chr18	48754204	48754254	51227834	51227884	19013	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-1				TAAGGGATAACCTAAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54710456909415839					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754121	48754171	51227751	51227801	19014	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-10				AATCCTAGGAAGACTACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10115478511870631					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754384	48754434	51228014	51228064	19015	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-11				AATTGTATTGTGTCTCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31275070368045782					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754233	48754283	51227863	51227913	19016	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-12				TCCTTATCTCCATTGTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03941603813978866					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754320	48754370	51227950	51228000	19017	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-13				CCTGTCGACTTAGAGGCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79105642794853726					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754186	48754236	51227816	51227866	19018	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-14				TGATACTAAGAGACACCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41695310271334779					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754079	48754129	51227709	51227759	19019	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-15				AAGGCTTGGGTCACTCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19777194162959291					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754093	48754143	51227723	51227773	19020	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-16				ACCCTTCAGAAATGAAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91163913341882608					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754260	48754310	51227890	51227940	19021	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-17				CTGATTTCATCTTGACAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23286808997621339					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754372	48754422	51228002	51228052	19022	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-2				ACAATACAATTCTGTCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61485444229817454					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754144	48754194	51227774	51227824	19023	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-3				GGGTTGTTGTGGTTTCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1532426325164796					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754357	48754407	51227987	51228037	19024	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-4				TGGCAGTCTTAACTTCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.299899229408161					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754133	48754183	51227763	51227813	19025	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-5				TTCCTAGGATTGGGTTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31746125440558781					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754293	48754343	51227923	51227973	19026	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-6				GAAGAGAGTTACAATTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37109670051009019					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754162	48754212	51227792	51227842	19027	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-7				ATTGGCTTTAATTATAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3484065505642739					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754337	48754387	51227967	51228017	19028	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-8				ATGAGGAGTAAAGTAGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0823194878137905					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48754222	48754272	51227852	51227902	19029	hg38	N/A	enh17711	N/A	Enhatls83787	enhancer	SMAD4e-5-9				TGGAGATAAGGAAGAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18869004991524349					MEX3C	chr18	51174549	51218333	7463				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761649	48761699	51235279	51235329	19030	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-1				CACAGCCTTACTAGTCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068644660410836361					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761918	48761968	51235548	51235598	19031	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-10				ATAAGCTCTAAGAATCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.1490484232589608					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761747	48761797	51235377	51235427	19032	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-11				TTGTGTGAGATCTGTGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073389060783297877					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761617	48761667	51235247	51235297	19033	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-12				TCAGAAAGAGTGAATGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1673766483096833					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761707	48761757	51235337	51235387	19034	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-13				TGGCAGGGTGAGGCCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.211985053552123					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761800	48761850	51235430	51235480	19035	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-14				CACTAAAGGAAGTATAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67828956676000451					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761735	48761785	51235365	51235415	19036	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-15				TGTGAAAATGGAGGGAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.018378720551854					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761722	48761772	51235352	51235402	19037	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-16				GGAAGATGGGCAGAGTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36505608908806891					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761823	48761873	51235453	51235503	19038	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-2				CAACGACCTACTTAAGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33610920271689182					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761885	48761935	51235515	51235565	19039	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-3				TGCCCAACCTAATTCTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14239283006309811					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761677	48761727	51235307	51235357	19040	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-4				TGAGTCATCCAAAAGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2294937785762429					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761842	48761892	51235472	51235522	19041	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-5				AAGGGAATTACAAACCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016383050107631761					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761695	48761745	51235325	51235375	19042	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-6				GCCAGCAAGGGAAGTCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0174048585380957					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761868	48761918	51235498	51235548	19043	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-7				TTTGCTGACAGCTATTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33199461168045691					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761857	48761907	51235487	51235537	19044	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-8				GCTGTCAGCAAATTTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17622530776832279					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48761772	48761822	51235402	51235452	19045	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-6-9				ATGAGAATAAGCTGCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21222865802561161					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762720	48762770	51236350	51236400	19046	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-1				AGATTGCCGAAGGGACTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1247985195975502					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762679	48762729	51236309	51236359	19047	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-10				GACAATGGGCCTCTGAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30307253728174838					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762882	48762932	51236512	51236562	19048	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-11				TTACCACCAATGAAGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.056019088150271047					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762752	48762802	51236382	51236432	19049	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-12				GTCACAGGCTTCACCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71826773754495632					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762690	48762740	51236320	51236370	19050	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-13				TCTGAATCATGGAAGCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37038371196570968					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762949	48762999	51236579	51236629	19051	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-14				AAACAACAGATCCTTTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50759644753393052					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762938	48762988	51236568	51236618	19052	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-15				GAAGCTAAATTCCACAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22351232031677029					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762801	48762851	51236431	51236481	19053	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-16				TCATACTATACAAATAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.1376044633555771					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762866	48762916	51236496	51236546	19054	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-17				CAGCAGGCAAAGTGCATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37360282315565052					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762837	48762887	51236467	51236517	19055	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-18				ACTGACAGGCCAGAAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1114031917896444					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762596	48762646	51236226	51236276	19056	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-19				CAAAATACCTCCACCAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6637128597898887					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762617	48762667	51236247	51236297	19057	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-2				TGTAGGATAGTCAAAAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.024282563616616					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762769	48762819	51236399	51236449	19058	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-3				CCAAGGCATTCAATCCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42193424077630631					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762823	48762873	51236453	51236503	19059	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-4				AGAGAGGGCCAACCACTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31693851785236538					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762665	48762715	51236295	51236345	19060	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-5				TAAGCCTCAAACCAGACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14180299697630441					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762855	48762905	51236485	51236535	19061	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-6				GTGCATTTTAGGGCTCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1830510198110385					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762783	48762833	51236413	51236463	19062	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-7				TAAGGAAAGGATTGCCTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1237450882908116					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762737	48762787	51236367	51236417	19063	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-8				CAATCTCTGGTATGAGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18740230173725889					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78101	chr18	48762894	48762944	51236524	51236574	19064	hg38	N/A	enh32683	N/A	Enhatls83787	enhancer	SMAD4e-7-9				ATTGGTGGTAATGGTGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.333413656541365					MEX3C	chr18	51174549	51218333	13923				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2119
enhrx-78102	chr18	48944804	48944854	51418434	51418484	19065	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-1				AACGCAATTGGTTTGTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034410251574134493					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944657	48944707	51418287	51418337	19066	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-10				ATATCAAGGCCTCTGCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2391899994117378					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944045	48944095	51417675	51417725	19067	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-11				CTAGATTCTTGCATATGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48442495926669232					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944074	48944124	51417704	51417754	19068	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-12				TGTGACTGTCACAGGACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34705970733727137					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944643	48944693	51418273	51418323	19069	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-13				AATCACGTGTACAGATATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69201526916813449					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944845	48944895	51418475	51418525	19070	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-14				GAAAGCAGGTCGCCGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19697532655638531					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944187	48944237	51417817	51417867	19071	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-15				GAGATGACACAACACATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.014266261147758809					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944329	48944379	51417959	51418009	19072	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-16				ATGGGGAGACAGACACTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22801585727335311					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944856	48944906	51418486	51418536	19073	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-17				CGACCTGCTTTCTCAACATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1239551028014976					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944346	48944396	51417976	51418026	19074	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-18				TCAAAATCTCTAGAGATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3041736729211641					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944056	48944106	51417686	51417736	19075	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-19				CATATGTGATGGCTTCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80796409169068961					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944278	48944328	51417908	51417958	19076	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-2				CATTACACCTGATTGCAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36389041886020629					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944922	48944972	51418552	51418602	19077	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-20				CATACATGAGCAGTGGGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.225440171293714					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944827	48944877	51418457	51418507	19078	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-21				AGAGGGTTTATCTTTTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05730848688251209					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944722	48944772	51418352	51418402	19079	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-22				CATTTACATAGCCCACAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47682346428768779					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944491	48944541	51418121	51418171	19080	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-23				ATGTCTATGCCTGACTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49982440995901878					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944984	48945034	51418614	51418664	19081	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-24				AGGGTATATACCGCAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0054810764190234293					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944520	48944570	51418150	51418200	19082	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-25				TAGAAGCTTTTATATGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58472927635862293					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944412	48944462	51418042	51418092	19083	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-26				GAAAGGGTGAAAGTTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071548531210319455					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944536	48944586	51418166	51418216	19084	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-27				TAAATGGAAGCAGCTGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.43709758650728942					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944598	48944648	51418228	51418278	19085	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-28				TCCTTGTCATCACATGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36959987691617591					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944632	48944682	51418262	51418312	19086	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-29				GTACACGTGATTTTATCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13289685407320409					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944089	48944139	51417719	51417769	19087	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-3				CAGTCACACTAGGTGGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068896185170428642					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944433	48944483	51418063	51418113	19088	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-30				GGAATTTTCCTTTAAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.372442669068338					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944137	48944187	51417767	51417817	19089	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-31				TTTTCTCATATGCTTTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0324882296064639					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944672	48944722	51418302	51418352	19090	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-32				ATGCAAATGCGGCCTCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47965733518792808					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944554	48944604	51418184	51418234	19091	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-33				ATTGAATGTACCTGACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45131905663217148					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944711	48944761	51418341	51418391	19092	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-34				GGGAGGGCCAGCCTTTTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70232890760302713					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944228	48944278	51417858	51417908	19093	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-35				CAAAGGGAGACAGGAAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2414671608763562					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944946	48944996	51418576	51418626	19094	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-36				TCAAGAAAGAATTCAGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36267088974905348					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944587	48944637	51418217	51418267	19095	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-37				TGATGACAAGGAAAAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.666822664935951					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944461	48944511	51418091	51418141	19096	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-38				CTGTTAGAGAAGAAATAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035338315830205573					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944616	48944666	51418246	51418296	19097	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-39				CTGGAGGCTGCCATGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79469406608097393					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944295	48944345	51417925	51417975	19098	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-4				ACTAGGGTTACTCATATCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69471796798177432					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944257	48944307	51417887	51417937	19099	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-40				TGGGTGGGGTGGAGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27262665069835179					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944750	48944800	51418380	51418430	19100	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-41				CCTGGTCAAAGCAATCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25976546336877931					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944384	48944434	51418014	51418064	19101	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-42				GTTATTAAGAAATTATTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.8571895265179759					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944767	48944817	51418397	51418447	19102	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-43				GTTTGATTTACATAGGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08915679178539615					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944683	48944733	51418313	51418363	19103	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-44				AGTCTTTTATTATGCAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31629032683684932					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944694	48944744	51418324	51418374	19104	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-45				TAATAAAAGACTAGGGTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1378284854954219					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944244	48944294	51417874	51417924	19105	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-46				GAGAAGAAGGAAAGAACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63975074116350228					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944213	48944263	51417843	51417893	19106	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-47				AGTGAGGGAAAAAGGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.96191508195421649					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944172	48944222	51417802	51417852	19107	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-5				ATGCCTGGCCAAGAGATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15939679272591681					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944395	48944445	51418025	51418075	19108	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-6				ATTATTTTTAGGCGCTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57047515593905085					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944107	48944157	51417737	51417787	19109	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-7				CCTGGACTAGGCATGTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32723319532866152					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944965	48945015	51418595	51418645	19110	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-8				TTGACCGAGACCAAGAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21603021090724239					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78102	chr18	48944816	48944866	51418446	51418496	19111	hg38	N/A	enh60718	N/A	Enhatls83788	enhancer	SMAD4e-8-9				CTTTTGTGGTGGAACGCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0173568252420889					MEX3C	chr18	51174549	51218333	197769				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2120
enhrx-78103	chr18	49048807	49048857	51522437	51522487	19112	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-1				ATTCTCATGTTTACAGCGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47021979345981157					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49049049	49049099	51522679	51522729	19113	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-10				GGGCTTGGGAGAAACTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65492750079052087					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048951	49049001	51522581	51522631	19114	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-11				TCGCTGAGCCCAGCTGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1079899251022971					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048877	49048927	51522507	51522557	19115	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-12				GGTGTCAGAAAGCTCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55879777812497655					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048848	49048898	51522478	51522528	19116	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-13				TGGGAATCTGAGAGTCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1140829549537106					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048863	49048913	51522493	51522543	19117	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-14				CATTCAGGTGACTTCCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.076963940834583827					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048693	49048743	51522323	51522373	19118	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-15				AGGCTTTCTCCCCTTCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12527745349070391					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048732	49048782	51522362	51522412	19119	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-16				GAAATGTGTGGCTGGGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1881779113747539					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49049003	49049053	51522633	51522683	19120	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-17				ATCAGGGAATCAGGCAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46780127380129988					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048902	49048952	51522532	51522582	19121	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-18				CTACCTGAGGGTCTGGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80740009044267924					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048706	49048756	51522336	51522386	19122	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-19				GAGAAAGCCTGGCAGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1391399262528826					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048770	49048820	51522400	51522450	19123	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-2				CCTGAGGTGCTTGAAACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058263658391288893					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048821	49048871	51522451	51522501	19124	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-20				AGCGGTTGGTGGGGGGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7133567882728731					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49049019	49049069	51522649	51522699	19125	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-3				TAGCCTTGGCGAGGGAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0021069216344609					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49049033	49049083	51522663	51522713	19126	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-4				GAATGGGCTCCCTGTAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41310641442739238					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048976	49049026	51522606	51522656	19127	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-5				GTGACTTTGCTGTTAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.528786605448227					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048913	49048963	51522543	51522593	19128	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-6				ACCCTCAGGTAGAGCCAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.061804063578561837					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048758	49048808	51522388	51522438	19129	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-7				AGCACCTCAGGACAAGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35300226595963419					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048936	49048986	51522566	51522616	19130	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-8				CTCAGCGACAGGGCAGCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0629178575736158					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-78103	chr18	49048744	49048794	51522374	51522424	19131	hg38	N/A	enh58819	N/A	Enhatls83789	enhancer	SMAD4e-9-9				AGATGAGGGTCTGAAATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32867096988708472					MEX3C	chr18	51174549	51218333	302448				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2121
enhrx-lit508	chr18	48554657	48554707	51028287	51028337	19132	hg38					enhancer	SMAD4e+1-1				AGGCGCCACCTACATTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72774770565635016													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit509	chr18	48554847	48554897	51028477	51028527	19133	hg38					enhancer	SMAD4e+1-10				CCACATGGCAAGGAACAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26425521843157679													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit510	chr18	48554570	48554620	51028200	51028250	19134	hg38					enhancer	SMAD4e+1-11				GCATAAATAAATACATGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.218468130909927													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit511	chr18	48554818	48554868	51028448	51028498	19135	hg38					enhancer	SMAD4e+1-12				CCATATTGTTAGCTTCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.526684576900613													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit512	chr18	48554832	48554882	51028462	51028512	19136	hg38					enhancer	SMAD4e+1-13				TCCCTATGGAGAGCACCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.235927796527031													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit513	chr18	48554627	48554677	51028257	51028307	19137	hg38					enhancer	SMAD4e+1-14				CACACAAAAGCTTGAACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22182313323956521													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit514	chr18	48554788	48554838	51028418	51028468	19138	hg38					enhancer	SMAD4e+1-2				TCCCGTTGCTGGCTTCGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.299839589960507													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit515	chr18	48554672	48554722	51028302	51028352	19139	hg38					enhancer	SMAD4e+1-3				TGGCGCCTGTGATTTGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21477342701311261													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit516	chr18	48554692	48554742	51028322	51028372	19140	hg38					enhancer	SMAD4e+1-4				TGGCCAGCAATGTATGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40838102883247362													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit517	chr18	48554777	48554827	51028407	51028457	19141	hg38					enhancer	SMAD4e+1-5				GCTGAGACTCTTCCCGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1238274122909048													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit518	chr18	48554537	48554587	51028167	51028217	19142	hg38					enhancer	SMAD4e+1-6				GAGAAGAGGTTGAGCTTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52175057792598023													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit519	chr18	48554585	48554635	51028215	51028265	19143	hg38					enhancer	SMAD4e+1-7				TGGTGTGGTAGACTCTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36291293918306328													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit520	chr18	48554879	48554929	51028509	51028559	19144	hg38					enhancer	SMAD4e+1-8				CAACAGCCTGCAAAGGACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039680179833704123													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit521	chr18	48554608	48554658	51028238	51028288	19145	hg38					enhancer	SMAD4e+1-9				CAGGAGGTGGGAATCATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.06143581659974													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-78063	chr18	48275130	48275180	50748760	50748810	19146	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-1				ATGCAAGAATAAGGCAACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44528713863768993					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275184	48275234	50748814	50748864	19147	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-10				ACAGATTGCTGATAACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45364669158748361					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275102	48275152	50748732	50748782	19148	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-11				TCTGAAGCAGAGCTGCGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33450916545932508					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274809	48274859	50748439	50748489	19149	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-12				CTTGGTCTCCTCAGGCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25954909419742322					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274909	48274959	50748539	50748589	19150	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-13				CTGCTGTGCAAGTGACAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23692158741188921					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274857	48274907	50748487	50748537	19151	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-14				GGCAGGTCTAGGCTTGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67765738096073713					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274980	48275030	50748610	50748660	19152	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-15				AAGGGTGGGTGAGCCTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5396976564741679					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274920	48274970	50748550	50748600	19153	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-16				GTGACAAACAGGTCACTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069299627123184313					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274834	48274884	50748464	50748514	19154	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-17				CCCAGCAGGTTCCCGCCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17551141371462839					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274820	48274870	50748450	50748500	19155	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-18				CAGGCAAATAGGCTCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15750304089179071					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274870	48274920	50748500	50748550	19156	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-19				TAGACCTGCCTCCCTCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.388910352069781					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274965	48275015	50748595	50748645	19157	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-2				TCGACTTCAAAGAGGAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.454629884206085					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274681	48274731	50748311	50748361	19158	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-20				ACAGGAAGGGGCTCTGAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1171335296512903					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274694	48274744	50748324	50748374	19159	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-21				GCCTCAGGCAGCCACAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90588851738624132					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274845	48274895	50748475	50748525	19160	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-22				CTTGCTTGGGGCCTGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34603568293936349					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275085	48275135	50748715	50748765	19161	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-23				TGTTGGGGCTGGAGAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13808561212893389					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274644	48274694	50748274	50748324	19162	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-24				CTGTGACTGCAGGAGCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.022539783571722219					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275074	48275124	50748704	50748754	19163	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-25				GAGAACAGCTGGGGAGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.06833769666781965					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274785	48274835	50748415	50748465	19164	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-26				CTTAAATAAAGGCAGAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.999018379041567					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274883	48274933	50748513	50748563	19165	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-27				CTCTCCTGGGGCTCAGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18422047971256281					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274737	48274787	50748367	50748417	19166	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-28				GGAGGCAGGAAAAGGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88719849982815424					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274737	48274787	50748367	50748417	19167	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-28				GGAGGCAGGAAAAGGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.88719849982815424					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275146	48275196	50748776	50748826	19168	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-3				ACGCAGGAATCCGGCCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30794897099419832					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274993	48275043	50748623	50748673	19169	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-4				CCTGCTAGGGTTATAGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0006945599286339205					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275169	48275219	50748799	50748849	19170	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-5				CAATCTGTTCAGATCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56050164424685556					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275053	48275103	50748683	50748733	19171	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-6				GGATAATCACTCTCACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043511046055226772					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48275053	48275103	50748683	50748733	19172	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-6				GGATAATCACTCTCACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043511046055226772					MAPK4	chr18	50560086	50731826	16873				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274755	48274805	50748385	50748435	19173	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-7				AGCGTTCAAGCAGTAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61463111287315864					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274755	48274805	50748385	50748435	19174	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-7				AGCGTTCAAGCAGTAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61463111287315864					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274774	48274824	50748404	50748454	19175	hg38	N/A	enh69464	fant55153	Enhatls83748	enhancer	SMAD4e+10-8				CGCTCCCTTTCCTTAAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82724674236871087					MAPK4	chr18	50560086	50731826	16565				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48274709	48274759	50748339	50748389	19176	hg38	N/A	enh69464	N/A	Enhatls83748	enhancer	SMAD4e+10-9				TTTGTAGAACTTAGAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40741808615563652					MAPK4	chr18	50560086	50731826	14617				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263592	48263642	50737222	50737272	19177	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-1				GGAGACTAAGTAGGTCACGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20774779474618971					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263769	48263819	50737399	50737449	19178	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-10				TGTGCAGGGTTTGAGCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.029298634941503109					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263604	48263654	50737234	50737284	19179	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-11				ACTTAGTCTCCAGCCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25084675126088829					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263702	48263752	50737332	50737382	19180	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-12				GCTCAGAGGTTATCTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.180951445406858					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263629	48263679	50737259	50737309	19181	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-13				ACACTGATACAGCATGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066463484579508958					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263523	48263573	50737153	50737203	19182	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-14				AAGGCTCAGGTGACATTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02440030045593412					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263618	48263668	50737248	50737298	19183	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-15				CTGTATCAGTGTGACCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0017264183012982489					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263744	48263794	50737374	50737424	19184	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-16				TCAAAGAAAGGCCTGTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01151667007283365					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263646	48263696	50737276	50737326	19185	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-17				TTTTGTGTGCCTGAGTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19618666140106189					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263755	48263805	50737385	50737435	19186	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-18				GCCTTTCTTTGAAATGTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.035729784954197819					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263536	48263586	50737166	50737216	19187	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-19				AACCCTGGACTCCAAGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30062205785431578					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263673	48263723	50737303	50737353	19188	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-2				AATAGACGGCCTGATAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42299598684411149					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263551	48263601	50737181	50737231	19189	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-3				GACCATCCCCATAGAAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052013469913918232					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263718	48263768	50737348	50737398	19190	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-4				ACAGGTTCTTGATTGGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39320711765211391					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263688	48263738	50737318	50737368	19191	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-5				CGTCTATTCCAAGGGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19319544500161609					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263494	48263544	50737124	50737174	19192	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-6				AATACTACCCACATCGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1216323051545693					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263459	48263509	50737089	50737139	19193	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-7				CATCTTCATGCAATTCTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064103434338152729					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263733	48263783	50737363	50737413	19194	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-8				GAACCTGTCCTCCTAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.025190258378467049					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48263797	48263847	50737427	50737477	19195	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+11-9				TGTGCAGTAAAGGGTTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2310221563300342					MAPK4	chr18	50560086	50731826	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78058	chr18	48171564	48171614	50645194	50645244	19196	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-1				AATGCCAACGCGCCATCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05343225416157299					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171610	48171660	50645240	50645290	19197	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-10				TGTTATTTCTAAGGCCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33979392297020949					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171328	48171378	50644958	50645008	19198	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-11				GACACTGCTCAAACTTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48823430657602362					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171386	48171436	50645016	50645066	19199	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-12				GCCATCTAGAGGGAAGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2976645115737888					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171469	48171519	50645099	50645149	19200	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-13				AACTGGTGGAAGGCGGGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27685459410689089					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171293	48171343	50644923	50644973	19201	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-14				CTCTTCTAGAAGCTGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17920517627359561					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171342	48171392	50644972	50645022	19202	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-15				TTGCAGTGGAGAATAATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20258224163745689					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171172	48171222	50644802	50644852	19203	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-16				GGGCACCGCAGAGAAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38214800677207761					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171631	48171681	50645261	50645311	19204	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-17				CAGCTGGGGTTAAAGATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.758171079117577					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171358	48171408	50644988	50645038	19205	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-18				TGGATGGGATGGGGATTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.405954714539299					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171220	48171270	50644850	50644900	19206	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-19				AATGGTGAAAAAACATCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99137237848253879					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171488	48171538	50645118	50645168	19207	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-2				ATGGCGAAAGACACGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15640906647623479					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171281	48171331	50644911	50644961	19208	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-20				TTCTAGAAGAGGATGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.810241183712617					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171539	48171589	50645169	50645219	19209	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-21				GCACTGGGATTAAAGATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.196710323216403					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171455	48171505	50645085	50645135	19210	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-22				AGAGTGGCAGGGAGAACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049635586604728478					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171410	48171460	50645040	50645090	19211	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-23				GAGCAGAAGGAGAGGCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69058816588700134					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171422	48171472	50645052	50645102	19212	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-24				AGGCCTGCAGGCCAGGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34036942128628511					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171433	48171483	50645063	50645113	19213	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-25				TCTCCCAGCCACCCACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22914728559534631					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171444	48171494	50645074	50645124	19214	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-26				GTGGCTGGGAGAGAGTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50167062117860839					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171263	48171313	50644893	50644943	19215	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-27				GTGGGAGTGGGTGGGATGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8979459747470511					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171397	48171447	50645027	50645077	19216	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-28				GGAAGGTGAGGGAGAGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095580079725989142					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171375	48171425	50645005	50645055	19217	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-3				TGCAGGCGAGAGCCATCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0817284991942298					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171598	48171648	50645228	50645278	19218	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-4				GGCCACTATGGATGGCGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1099772673674429					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171197	48171247	50644827	50644877	19219	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-5				CAGCAAGCGACCTTGGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32396388300146878					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171238	48171288	50644868	50644918	19220	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-6				AATAGCACGTCTTATGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.367578696945117					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171576	48171626	50645206	50645256	19221	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-7				GCATTCATCTCTCCTATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.839274749775409					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171524	48171574	50645154	50645204	19222	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-8				TGCTGAACATCTACAGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1425312021032179					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78058	chr18	48171305	48171355	50644935	50644985	19223	hg38	N/A	N/A	N/A	Enhatls83743	enhancer	SMAD4e+12-9				CTGCCACATGGCTATTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1673083667947754					MAPK4	chr18	50560086	50731826	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2076
enhrx-78057	chr18	48033514	48033564	50507144	50507194	19224	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-1				CATGATGTGCCCACGTGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25042025954767788					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033667	48033717	50507297	50507347	19225	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-10				ACTGCCCTCAAGTGGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.084058775532441135					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033501	48033551	50507131	50507181	19226	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-11				CGTGATCAGGAGGCCTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4975361451289739					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033488	48033538	50507118	50507168	19227	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-12				GGAGAGAATGACCCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25887698913945673					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033742	48033792	50507372	50507422	19228	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-13				CTGCCTAGGCTGCTGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13206337036307689					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033693	48033743	50507323	50507373	19229	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-14				TCCCCACTGCAGCTGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44000345666696372					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033540	48033590	50507170	50507220	19230	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-15				ACATTAACATATGAATGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034875188904054368					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033614	48033664	50507244	50507294	19231	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-2				GAGACATACCAGGATTAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3429846427894071					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033573	48033623	50507203	50507253	19232	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-3				TGTCAATGCTGTCAAATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0684889914135482					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033843	48033893	50507473	50507523	19233	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-4				GAACCACACTGTGTTCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.172401322090666					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033637	48033687	50507267	50507317	19234	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-5				TGGTGAGTTCTGGACCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23608879250992371					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033652	48033702	50507282	50507332	19235	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-6				CATTGAGGTCCCCAGCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0023170274927631					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033794	48033844	50507424	50507474	19236	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-7				GAAATAACAGACAGCAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45515930537878763					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033768	48033818	50507398	50507448	19237	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-8				CAGAAGGACTTTGCAGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12672169100603031					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	48033728	48033778	50507358	50507408	19238	hg38	N/A	enh110923	N/A	Enhatls83742	enhancer	SMAD4e+13-9				AGCAATGATTCTCCCTGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25064175264093552					MAPK4	chr18	50560086	50731826	50702				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925649	47925699	50399279	50399329	19239	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-1				GAACCTCTGTAGTATGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068309109149579578					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925721	47925771	50399351	50399401	19240	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-10				ATGGCTCCTGCTCCATAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49424441633812771					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925710	47925760	50399340	50399390	19241	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-11				TCCATAGACAGGATCTGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23261042687622421					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925623	47925673	50399253	50399303	19242	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-12				AGACTTGCTTCCACCCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2448050225450725					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925526	47925576	50399156	50399206	19243	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-13				TGTTGTTCTTGACAGTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1197194378514521					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925457	47925507	50399087	50399137	19244	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-14				TCTAGCAGGTCTGCCTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.030391734862282					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925786	47925836	50399416	50399466	19245	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-15				AATCACAGCAGAGAAATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18942412476988121					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925543	47925593	50399173	50399223	19246	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-16				GTAGAGCAATTTAAGCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.097589357477412667					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925664	47925714	50399294	50399344	19247	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-17				GGAGTAGGAGCTGGGGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52128641948424159					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925580	47925630	50399210	50399260	19248	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-2				GCAGTCAAGCCCCTTCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.184862497361872					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925748	47925798	50399378	50399428	19249	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-3				GCGGGGTAGGGAGTAGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66180609913702038					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925443	47925493	50399073	50399123	19250	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-4				CTTCCCATTGAGCTTCTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38449920431021689					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925638	47925688	50399268	50399318	19251	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-5				CTACAGAGGTTCAGTCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60889392023913258					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925469	47925519	50399099	50399149	19252	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-6				GCCTCTGTTGGTATCTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50167459704654815					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925494	47925544	50399124	50399174	19253	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-7				GTTAGCCTCCATTAATTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.09997994875132675					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925736	47925786	50399366	50399416	19254	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-8				GGAGCCATGGATGCGGGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10805309671148849					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47925591	47925641	50399221	50399271	19255	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+14-9				GCAATACCCTGCCCCTGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35302844542297018					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922490	47922540	50396120	50396170	19256	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-1				TGCGTGTCAGTAGCATAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.166102257265405					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922544	47922594	50396174	50396224	19257	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-10				TACAGAAGATAAGAAGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.447899798040095					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922472	47922522	50396102	50396152	19258	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-11				GCTAACCAGAGTTCAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30218535270140928					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922689	47922739	50396319	50396369	19259	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-12				CCCAATTGAGGCAGGAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69884400745464714					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922763	47922813	50396393	50396443	19260	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-13				ATATCCTCTCCATAGGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2189336188376397					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922786	47922836	50396416	50396466	19261	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-14				AAGTGATAAAATCATTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2569136051742871					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922738	47922788	50396368	50396418	19262	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-15				ATTCACACTTCAGCTATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3389455674393983					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922712	47922762	50396342	50396392	19263	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-16				GTCTGGAGGCAAGGAACATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1007920074482008					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922812	47922862	50396442	50396492	19264	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-17				TATGCCCTATGTAAATGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22019525993583591					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922677	47922727	50396307	50396357	19265	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-2				CCTAAAAACCAGCCCAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57925333007002655					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922570	47922620	50396200	50396250	19266	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-3				AGATAATCACGGCAGTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50136912873915562					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922603	47922653	50396233	50396283	19267	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-4				TGACTCCACTTGGGGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.016337378465078					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922440	47922490	50396070	50396120	19268	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-5				TGAGGCAGTGTAATGGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.528114985953091					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922644	47922694	50396274	50396324	19269	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-6				AACTTGAGAGTGCAATTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0068559757607558978					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922588	47922638	50396218	50396268	19270	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-7				TGGAGTCAGCAAGGGCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.055012194481312122					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922559	47922609	50396189	50396239	19271	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-8				CTTCTGTAACAAGATAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035545894772983942					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-78057	chr18	47922618	47922668	50396248	50396298	19272	hg38	N/A	N/A	N/A	Enhatls83742	enhancer	SMAD4e+15-9				GTAGGAGGTGAGAGAAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19555001525392329					SKA1	chr18	50375039	50394168	3				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2075
enhrx-lit522	chr18	47795072	47795122	50268702	50268752	19273	hg38					enhancer	SMAD4e+16-1				CGATTCACTTACCTAGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.028390278090081131													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit523	chr18	47794903	47794953	50268533	50268583	19274	hg38					enhancer	SMAD4e+16-10				CGCTCGTCACCCATCACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59991858531338671													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit524	chr18	47794989	47795039	50268619	50268669	19275	hg38					enhancer	SMAD4e+16-11				ACCTGCTGGTGGGTCCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0336543800144985													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit525	chr18	47794628	47794678	50268258	50268308	19276	hg38					enhancer	SMAD4e+16-12				CCGCCCGTTGGGGATTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2456413012227832													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit526	chr18	47795086	47795136	50268716	50268766	19277	hg38					enhancer	SMAD4e+16-13				AGTGAATCGCTCAGGGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05021657069816686													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit527	chr18	47794784	47794834	50268414	50268464	19278	hg38					enhancer	SMAD4e+16-14				AAACAGGCAAAACCGAACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85557799205597573													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit528	chr18	47794915	47794965	50268545	50268595	19279	hg38					enhancer	SMAD4e+16-15				GGTGACGAGCGGTGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3555109324256489													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit529	chr18	47794735	47794785	50268365	50268415	19280	hg38					enhancer	SMAD4e+16-16				AGGGCGGGGCTCGACGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.655776735587742													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit530	chr18	47794840	47794890	50268470	50268520	19281	hg38					enhancer	SMAD4e+16-17				TCTGGCCCTAGCCCAAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.352562765974553													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit531	chr18	47795003	47795053	50268633	50268683	19282	hg38					enhancer	SMAD4e+16-18				GCCGGACACCTTCAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3708482557066155													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit532	chr18	47795103	47795153	50268733	50268783	19283	hg38					enhancer	SMAD4e+16-19				ATCAAGGTCACTTCTTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89319247317959827													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit533	chr18	47794668	47794718	50268298	50268348	19284	hg38					enhancer	SMAD4e+16-2				TCGCCTCAGAAATTCCGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35120373595053189													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit534	chr18	47794645	47794695	50268275	50268325	19285	hg38					enhancer	SMAD4e+16-20				CCAAGGTTGTGCAGCCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29806294101664088													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit535	chr18	47794809	47794859	50268439	50268489	19286	hg38					enhancer	SMAD4e+16-21				GAGTCCCCCTCTTCAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23130960886025231													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit536	chr18	47794947	47794997	50268577	50268627	19287	hg38					enhancer	SMAD4e+16-22				GTGACTGTGGCTGGGAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.105169614832243													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit537	chr18	47794932	47794982	50268562	50268612	19288	hg38					enhancer	SMAD4e+16-23				ACAGTCACCCACCGGGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042037949011310818													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit538	chr18	47795139	47795189	50268769	50268819	19289	hg38					enhancer	SMAD4e+16-24				CCACTATCCCAGTTTCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62217781180081													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit539	chr18	47794822	47794872	50268452	50268502	19290	hg38					enhancer	SMAD4e+16-25				AGGGGGACTCAGCTTCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036258321764844843													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit540	chr18	47795025	47795075	50268655	50268705	19291	hg38					enhancer	SMAD4e+16-26				AGGCTCTTGGTGCTCAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42601980735782441													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit541	chr18	47795119	47795169	50268749	50268799	19292	hg38					enhancer	SMAD4e+16-27				TGGGTGGGAAGATCAAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0289600483376517													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit542	chr18	47795055	47795105	50268685	50268735	19293	hg38					enhancer	SMAD4e+16-28				CAGCCAACCCCCCGCCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.035208132580375													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit543	chr18	47794750	47794800	50268380	50268430	19294	hg38					enhancer	SMAD4e+16-29				AGCTCGCCCAGGGTGAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66336425506172925													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit544	chr18	47794962	47795012	50268592	50268642	19295	hg38					enhancer	SMAD4e+16-3				AACTACGGGCTTTCTCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17064890721019													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit545	chr18	47794888	47794938	50268518	50268568	19296	hg38					enhancer	SMAD4e+16-30				ACCCCTGGCCTGGCCGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058303555024578263													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit546	chr18	47794975	47795025	50268605	50268655	19297	hg38					enhancer	SMAD4e+16-31				CTCGCCCCGGCGCCCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.259122308008625													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit547	chr18	47795038	47795088	50268668	50268718	19298	hg38					enhancer	SMAD4e+16-32				TGGCTGAAGGCTGAGGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9618972482642789													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit548	chr18	47794698	47794748	50268328	50268378	19299	hg38					enhancer	SMAD4e+16-4				AACCGACCCTTGGCGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3955469162900947													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit549	chr18	47794717	47794767	50268347	50268397	19300	hg38					enhancer	SMAD4e+16-5				CTAGGACGTTCGAGTGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33341129488010518													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit550	chr18	47794772	47794822	50268402	50268452	19301	hg38					enhancer	SMAD4e+16-6				TCCGAAATTTAACCCCGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18673831019560941													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit551	chr18	47794761	47794811	50268391	50268441	19302	hg38					enhancer	SMAD4e+16-7				TTAAATTTCGGAGCTCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2351625393760006													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit552	chr18	47794856	47794906	50268486	50268536	19303	hg38					enhancer	SMAD4e+16-8				GTACTGGGGTTTGCGCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19100098912517161													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit553	chr18	47794875	47794925	50268505	50268555	19304	hg38					enhancer	SMAD4e+16-9				ACGGAGACCACGCCCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8012876108341178													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-78036	chr18	47759015	47759065	50232645	50232695	19305	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-1				CTAATGGCCTTATGCTAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19728183859007309					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759032	47759082	50232662	50232712	19306	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-10				AATAGGCTCTCTGCTCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60841274944727741					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758909	47758959	50232539	50232589	19307	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-11				TAAATTTTAAAAGCCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26177066141945321					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758995	47759045	50232625	50232675	19308	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-12				TAGGGGTTGAGATTCTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26789984333410438					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758927	47758977	50232557	50232607	19309	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-13				TGTGGCAGAGAGAGTAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0004825642644375032					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758957	47759007	50232587	50232637	19310	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-14				CAGGGCAGTCTTTTTTCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031413442055308362					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758945	47758995	50232575	50232625	19311	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-15				TTTTCCAGTGGCTGAGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40334454791526481					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759137	47759187	50232767	50232817	19312	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-2				ACTTTTGTTTATCTCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01039599691153195					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759094	47759144	50232724	50232774	19313	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-3				GAATTTATCCCACACCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12625535596925941					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759119	47759169	50232749	50232799	19314	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-4				TGGGGTGCTAATGCTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67299135897197337					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758968	47759018	50232598	50232648	19315	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-5				AAGACTGCCCTGATGATCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.096830783149517846					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759065	47759115	50232695	50232745	19316	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-6				ACTTTGCAAGTTATCAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34401867074045511					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759169	47759219	50232799	50232849	19317	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-7				ACTGACCTTGCACTGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16982610476954019					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759108	47759158	50232738	50232788	19318	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-8				ATTAGCACCCCAGACCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19311290692456121					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47759209	47759259	50232839	50232889	19319	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+17-9				AAAAGGTCAGGCTTTACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23897153831809539					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758014	47758064	50231644	50231694	19320	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-1				CACCGGATAGTAGCCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1901352363573284					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757978	47758028	50231608	50231658	19321	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-10				GCTGGCTTTTAGTATCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22922064614092519					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758334	47758384	50231964	50232014	19322	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-11				TCACCCATTTTCCTTGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18021438817539179					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758298	47758348	50231928	50231978	19323	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-12				CCCCTCTCCTGGGCCAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.213001797216239					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758001	47758051	50231631	50231681	19324	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-13				CAACTGACAGTAACCAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.835848623154384					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758276	47758326	50231906	50231956	19325	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-14				GGTGGGTAAGGGAAAACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22765872632539119					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758208	47758258	50231838	50231888	19326	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-15				GAATGGCTGGCTGACTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1220422768806582					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758354	47758404	50231984	50232034	19327	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-16				TGGACTGGCCATCCAGCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01491990576520049					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757903	47757953	50231533	50231583	19328	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-17				GGTAGTTAGATGCTTCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5601258472586963					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758221	47758271	50231851	50231901	19329	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-18				AACATCTGGGACAGAATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33184578992759989					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757960	47758010	50231590	50231640	19330	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-19				CTTTTCAGCCTTTCAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048380388744197991					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757914	47757964	50231544	50231594	19331	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-2				CATCTAACTACCACCTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72315038590125957					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758152	47758202	50231782	50231832	19332	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-20				CAGAGCAAATTCACACATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1317774252315404					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758064	47758114	50231694	50231744	19333	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-21				AGGAAGCCTTCCTCTCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35316874493831663					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758192	47758242	50231822	50231872	19334	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-22				TCTCACTCTGAATCCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.036374359805827					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758311	47758361	50231941	50231991	19335	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-23				AGGGAGGACTCTGCCTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30263033189368332					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757927	47757977	50231557	50231607	19336	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-24				CTCAGGTCCCTCACCTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26947870750951908					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758287	47758337	50231917	50231967	19337	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-25				CCCTTACCCACCCCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1884157962115825					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757944	47757994	50231574	50231624	19338	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-26				TGAAAAGAGAAAGTAAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49160108243721728					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758371	47758421	50232001	50232051	19339	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-3				ATAAGGCCCCTGAGTGGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46781691948707449					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758084	47758134	50231714	50231764	19340	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-4				TTCTGACCAGAGAGTATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2045090991559273					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758114	47758164	50231744	50231794	19341	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-5				ATCCCTACGTGTGATGCGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0280789526544758					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758040	47758090	50231670	50231720	19342	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-6				CAGGTGGCTATTTGGCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.042168589555146817					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758025	47758075	50231655	50231705	19343	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-7				TACTATCCGGTGTTGCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096360794509946224					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47758234	47758284	50231864	50231914	19344	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-8				CACCTGATTTAGCAACATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00033940526638297					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78036	chr18	47757883	47757933	50231513	50231563	19345	hg38	N/A	N/A	N/A	Enhatls83721	enhancer	SMAD4e+18-9				CGGATACCTTTCAGTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43003577009141192					CFAP53	chr18	50227192	50266495	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2054
enhrx-78034	chr18	47655260	47655310	50128890	50128940	19346	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-1				GCCGCTGATTGGGTATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083812393003758132					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655487	47655537	50129117	50129167	19347	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-10				GCCATGCTCCCACCACCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32754057079069582					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655422	47655472	50129052	50129102	19348	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-11				AGAGCCGGCTCAGGAGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.071559356709965					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655329	47655379	50128959	50129009	19349	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-12				CACCTTCACAAAACACACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16664106827988109					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655208	47655258	50128838	50128888	19350	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-13				GTGGTTTCCCCCTTCTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40003301423620069					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655407	47655457	50129037	50129087	19351	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-14				TAATGCAGGGCTGTCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55452873076879483					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655451	47655501	50129081	50129131	19352	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-15				GGAATGCTCAGTGATGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48566839605802542					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655179	47655229	50128809	50128859	19353	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-16				ATGTGAAAGAACATTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1172638855453038					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655534	47655584	50129164	50129214	19354	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-17				GCTGGGCCCAAGCAGGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45654978438570543					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655464	47655514	50129094	50129144	19355	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-18				ATGTGAAAGGAGCCCAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1842960067810351					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655476	47655526	50129106	50129156	19356	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-19				ACCACCGTGGGGCCTGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41327482647545938					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655393	47655443	50129023	50129073	19357	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-2				GGTAAGTCACTGCTTAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2166710288138918					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655517	47655567	50129147	50129197	19358	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-20				ACGGAGAGGGATGGAGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045926621711661779					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655545	47655595	50129175	50129225	19359	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-21				GCAGGACTGTGGAGAGGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3635645408437727					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655378	47655428	50129008	50129058	19360	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-3				GACTTACCGTGAGATTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095220313639557741					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655304	47655354	50128934	50128984	19361	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-4				TTTTATTGACAAACCCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39255341249369841					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655279	47655329	50128909	50128959	19362	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-5				CGGCTGCCGGCTGGAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3770788788191074					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655234	47655284	50128864	50128914	19363	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-6				CACACCAAAGCAGTTTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.111769836866235					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655504	47655554	50129134	50129184	19364	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-7				CATGGCCTGATGGACGGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54218867548684113					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655317	47655367	50128947	50128997	19365	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-8				TTGTGAAGGTGATCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00088586846813829771					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78034	chr18	47655347	47655397	50128977	50129027	19366	hg38	N/A	enh52746	N/A	N/A	enhancer	SMAD4e+19-9				CTGTGATTTTAATTAGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34770066384631609					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2052
enhrx-78088	chr18	48552176	48552226	51025806	51025856	19367	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-1				ATTGCCGTGCTCCTAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15229356750480941					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552103	48552153	51025733	51025783	19368	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-10				TAATTGCTGGAGTGACAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13032474439374869					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552003	48552053	51025633	51025683	19369	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-11				GGTCAAAGAGAAGAATCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87076806010553454					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552203	48552253	51025833	51025883	19370	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-12				TTGCCTTCCCCACCCTCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39969153044014361					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48551982	48552032	51025612	51025662	19371	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-13				TGATAGCTGACAGTAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30537021121535152					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48551890	48551940	51025520	51025570	19372	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-14				GTATTCTGCTGTTGCAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27123348106446021					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552079	48552129	51025709	51025759	19373	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-15				TACTGATAAAACAGAATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11379364455702889					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552066	48552116	51025696	51025746	19374	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-16				TTTATCAGTATTTCTCTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4085737857684091					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552285	48552335	51025915	51025965	19375	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-17				TTGCTTCAATTTTCTAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56400364838965278					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552248	48552298	51025878	51025928	19376	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-18				TGGGTGATGCTGAGATTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26226615246018159					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48551864	48551914	51025494	51025544	19377	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-19				TTTGTATAAATGGTATTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60603396326576287					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552090	48552140	51025720	51025770	19378	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-2				CAGAATAGGCGGATAATTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55394195304387062					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48551945	48551995	51025575	51025625	19379	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-20				TTTAGAAGTTTTGTTGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0939015262231767					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48551959	48552009	51025589	51025639	19380	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-21				TGTAAAGGGAGTAGAGAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.130064464629694					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552190	48552240	51025820	51025870	19381	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-3				CACGGCAATTCAACCATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52831022034183661					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552129	48552179	51025759	51025809	19382	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-4				TTGATTAGGCAAGATAGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30015891049763771					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552165	48552215	51025795	51025845	19383	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-5				GTGACAATACTCCTTTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3093477641170892					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552223	48552273	51025853	51025903	19384	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-6				CAAAGTAGAGGCTGGTATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11104608762467839					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552308	48552358	51025938	51025988	19385	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-7				CTATTAATTGAGAATGATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47711987685762841					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552143	48552193	51025773	51025823	19386	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-8				TAGTACTGGAATCTATGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33890267499167492					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48552115	48552165	51025745	51025795	19387	hg38	N/A	enh17708	N/A	N/A	enhancer	SMAD4e+2-9				TGACAGTGAGGATCTTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012179225579017971					SMAD4	chr18	51028527	51085045	683				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78028	chr18	47515443	47515493	49989073	49989123	19388	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-1				TCATAATTGACAAGCTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.576452144979088					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515172	47515222	49988802	49988852	19389	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-10				CTTTGCACACTGTCCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.094378556658576418					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515299	47515349	49988929	49988979	19390	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-11				GTTATGTCCTGTTCTCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0046188576593397621					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515428	47515478	49989058	49989108	19391	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-12				AATTATGATGCAGAGTGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1095025521848261					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515360	47515410	49988990	49989040	19392	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-13				CCAATTTAAATATTACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0200715814208441					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515241	47515291	49988871	49988921	19393	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-14				ATGACATGATAAAATCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71072504414149007					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515415	47515465	49989045	49989095	19394	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-15				AGTGCTAAGGGCTGTGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42850073384434639					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515378	47515428	49989008	49989058	19395	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-16				AGGGCTGGGAGGCTCCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2285685196961309					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515392	47515442	49989022	49989072	19396	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-17				AAGCAGAGCTGAGGAGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60024293102078974					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515226	47515276	49988856	49988906	19397	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-18				ACACACACTCCTTGTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23715531317271171					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515253	47515303	49988883	49988933	19398	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-2				TATCATGTCATCGTGTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59120495364747871					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515501	47515551	49989131	49989181	19399	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-3				TTCAGGCCATGTTAGGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85984927108681308					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515284	47515334	49988914	49988964	19400	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-4				ACTTGCAAGCACTGACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37499786535622531					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515485	47515535	49989115	49989165	19401	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-5				TGCTCAATGCAGGATCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85002798517395439					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515472	47515522	49989102	49989152	19402	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-6				GCATTGAGCAAAATAGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56529580085596631					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515270	47515320	49988900	49988950	19403	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-7				CTTGCAAGTCTGATTTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.052521889675532778					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515205	47515255	49988835	49988885	19404	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-8				GTTCCCTGCTAAGCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37634485538435258					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78028	chr18	47515334	47515384	49988964	49989014	19405	hg38	N/A	N/A	N/A	Enhatls83712	enhancer	SMAD4e+20-9				TCAGCCAGAGTTTTCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1142783464479651					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2046
enhrx-78024	chr18	47485755	47485805	49959385	49959435	19406	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-1				TGTCTAGCGCTTTCGTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31725515835471513					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47486057	47486107	49959687	49959737	19407	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-10				CACTTACTAGAATTGCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1071534742071433					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485815	47485865	49959445	49959495	19408	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-11				TTACTCTGTATTCAGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35134394779651112					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485832	47485882	49959462	49959512	19409	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-12				GAGTAAATCCTCCTGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47663997768088878					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485784	47485834	49959414	49959464	19410	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-13				TTCTTAAGAAGTGGCCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63816060881411885					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485960	47486010	49959590	49959640	19411	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-14				GAATCCTCATCACAGGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20853255651995931					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485636	47485686	49959266	49959316	19412	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-15				GTGCTGACATCTGAAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.085776668942095555					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485843	47485893	49959473	49959523	19413	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-16				ACCTGGCCCAGCCTGCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074435989697874988					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485948	47485998	49959578	49959628	19414	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-17				GATGAGGATTCTTTGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32347397314653031					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485870	47485920	49959500	49959550	19415	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-18				AAACAGGGGGCGGGGGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39621024810993871					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485921	47485971	49959551	49959601	19416	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-19				AAGGAAATCACTCAGGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30676392057287538					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485769	47485819	49959399	49959449	19417	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-2				CGCTAGACAAGGAAACCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29912148233711122					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485701	47485751	49959331	49959381	19418	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-20				TGAATACATAAATGTGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12573443956217581					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485854	47485904	49959484	49959534	19419	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-21				GCTGGGCCAGGTGAGGAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51452069416835156					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47486029	47486079	49959659	49959709	19420	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-3				CAGGCGCTGTATCAAGTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1328362667912632					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47486007	47486057	49959637	49959687	19421	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-4				GTGTTGGAGCAATCAACGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.004571673455006588					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485665	47485715	49959295	49959345	19422	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-5				TGCACTATTCCGTGAACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27380089099513771					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485996	47486046	49959626	49959676	19423	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-6				ATCAACGGCAGGTCTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00912633431992185					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485625	47485675	49959255	49959305	19424	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-7				AGATGTCAGCACTTCTTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5473511477656241					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485897	47485947	49959527	49959577	19425	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-8				GTGAAATCAGCTCACTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33403844067012428					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78024	chr18	47485735	47485785	49959365	49959415	19426	hg38	N/A	N/A	N/A	Enhatls83708	enhancer	SMAD4e+21-9				AGGTGTGACTCCTGTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.081558102726602438					MYO5B	chr18	49822788	50195147	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2042
enhrx-78088	chr18	48544023	48544073	51017653	51017703	19427	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-1				CCTTGGTACCCGAGCCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047430565754367063					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543466	48543516	51017096	51017146	19428	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-10				AGATGGAGTCATCAGTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40980356838578591					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543440	48543490	51017070	51017120	19429	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-11				GGTTGTTTGGATGAGATCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29529710376447749					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543817	48543867	51017447	51017497	19430	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-12				AATGGAGATGATCTGTGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27717204836428849					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543427	48543477	51017057	51017107	19431	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-13				TGGAGTGCCTTGAGGTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70493002662625981					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544127	48544177	51017757	51017807	19432	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-14				GGAAGGGGGCCGCAGTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16472144799222541					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543854	48543904	51017484	51017534	19433	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-15				TGTGGTTCAAAAGCCCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23466988890901319					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544003	48544053	51017633	51017683	19434	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-16				AGGCATCTACATCTTTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24067873800171069					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544094	48544144	51017724	51017774	19435	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-17				GCTGTACCACCCAGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2151857170102551					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543959	48544009	51017589	51017639	19436	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-18				GGAGGGAAACACCTATGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62201044459254651					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543581	48543631	51017211	51017261	19437	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-19				GGAACTGGCTTCTTCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68136099034038611					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543655	48543705	51017285	51017335	19438	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-2				ACTGTGTAAGCCGCATTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15885369929006171					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543693	48543743	51017323	51017373	19439	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-20				TACCAACAAAGAACACTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18558716095281119					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543779	48543829	51017409	51017459	19440	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-21				AGTGGCTCTGCACTTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1179957700506504					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543531	48543581	51017161	51017211	19441	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-22				GACAGGGCAAACCTTGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.59584060850176712					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543638	48543688	51017268	51017318	19442	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-23				CACAGTCCTGACCCTACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1515946811745662					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543672	48543722	51017302	51017352	19443	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-24				TAGGTTTGAAACAAAGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.622578342170155					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543730	48543780	51017360	51017410	19444	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-25				CTGTGGTTAGGCCTGCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1235477531987756					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543713	48543763	51017343	51017393	19445	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-26				TGGGGAGCTTTTGTGGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1963438062414628					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543797	48543847	51017427	51017477	19446	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-27				ATTGCCAGGGAGCTGCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.134905466141009					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544069	48544119	51017699	51017749	19447	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-28				ACTGTGCTGCAGCTCATCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13856556394211211					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544051	48544101	51017681	51017731	19448	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-29				ACAGTGCTTTCTCAGGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.027437987398995708					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543552	48543602	51017182	51017232	19449	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-3				GGGTCTGCGATTGTCCACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42789907095507029					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543407	48543457	51017037	51017087	19450	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-30				ACTACAAAATCAAGTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04388955533091693					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543503	48543553	51017133	51017183	19451	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-31				CATGAGATTTGTAAAGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28758247128168551					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544037	48544087	51017667	51017717	19452	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-32				GGTTGAGGGAGCCTCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2973918948983627					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543931	48543981	51017561	51017611	19453	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-33				GGGAACCAGCCTCCCTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.146986393096155					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543602	48543652	51017232	51017282	19454	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-34				CTGCTCTCCCAGGAGAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16063300817657039					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543911	48543961	51017541	51017591	19455	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-35				AACCAGGTAGGAGGTGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4039516110216757					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544138	48544188	51017768	51017818	19456	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-36				GCAGTTCAAGGGCAGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23710825552554571					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48544106	48544156	51017736	51017786	19457	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-37				GGTGGTACAGCACAGAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.304904078500039					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543831	48543881	51017461	51017511	19458	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-38				GTGTACTGGGGAAGGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.183742203756237					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543627	48543677	51017257	51017307	19459	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-39				AGGATGGAGGGCCAGCTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17726219467260679					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543564	48543614	51017194	51017244	19460	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-4				GTCCACCGTGGCTTTGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.239239201830142					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543872	48543922	51017502	51017552	19461	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-40				CATCTTTAAGAAAAATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75930745018897994					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543942	48543992	51017572	51017622	19462	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-41				TCCCTGAAAAGGAGGAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58901927939131282					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543514	48543564	51017144	51017194	19463	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-42				TAAAGATGGAGGCAGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.074286009075595					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543615	48543665	51017245	51017295	19464	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-43				GGGAGAGCAGTGAGGATGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4910507381893137					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543976	48544026	51017606	51017656	19465	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-5				AAATAGCACCACATAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3190799539839641					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543368	48543418	51016998	51017048	19466	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-6				TCTACCGTCTCATAATGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.055257347254061492					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543741	48543791	51017371	51017421	19467	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-7				AGAATGCGGGTCCTGACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29316316420487348					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543763	48543813	51017393	51017443	19468	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-8				TAACTAACCAGTGTAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.206282697430512					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48543895	48543945	51017525	51017575	19469	hg38	N/A	enh17707	N/A	Enhatls83774	enhancer	SMAD4e+3-9				GGGGATGTTATTGTTGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26858607363653259					SMAD4	chr18	51028527	51085045	9063				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533504	48533554	51007134	51007184	19470	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-1				CGCCCGGGGGGCTATAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58798868165751728					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533472	48533522	51007102	51007152	19471	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-10				CAAGTCTGGTGACCTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1970513370908073					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533721	48533771	51007351	51007401	19472	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-11				AAGGAAGTTTATTAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75186491711333037					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533532	48533582	51007162	51007212	19473	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-12				GGAGAGGTCAGGAGAAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0383243661941003					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533689	48533739	51007319	51007369	19474	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-13				TCAGGGCTGCCTCCTGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.067728260951401345					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533740	48533790	51007370	51007420	19475	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-14				GAGAGACCCAAGGTCAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15189324770038781					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533647	48533697	51007277	51007327	19476	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-15				TCTATGGGGGAGAGAGACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22014236612908231					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533429	48533479	51007059	51007109	19477	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-16				AATGCAGCTGCAGAGTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.420171143166238					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533663	48533713	51007293	51007343	19478	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-17				TACAAAATGAGGGGTTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48175640007026649					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533391	48533441	51007021	51007071	19479	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-18				ATTGCAGGGCGGGCGGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4519719885061821					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533560	48533610	51007190	51007240	19480	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-19				GAAAATAGGAATTTACAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47075085929605193					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533521	48533571	51007151	51007201	19481	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-2				CGGGCGGCACTGGAGAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3867900968647171					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533674	48533724	51007304	51007354	19482	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-20				AGCCCTGAGCTTACAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.80189600574421771					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533378	48533428	51007008	51007058	19483	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-21				CGGGGGGGGGGGGGGTGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0168641517726531					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533701	48533751	51007331	51007381	19484	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-3				CGGGCTGTTCCACCACAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.192271030870842					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533402	48533452	51007032	51007082	19485	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-4				GGGTCAGCTGCATTGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1175168776811549					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533584	48533634	51007214	51007264	19486	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-5				CAAGATAATATACTGTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16181998800891581					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533602	48533652	51007232	51007282	19487	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-6				GCCGGTCAAGAGATGATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1296247928850125					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533452	48533502	51007082	51007132	19488	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-7				TGGCGCCTAGATAAGGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18879657311368339					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533486	48533536	51007116	51007166	19489	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-8				CAGGGTTTGCTCAGCAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62658337514696594					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48533549	48533599	51007179	51007229	19490	hg38	N/A	enh17706	N/A	Enhatls83774	enhancer	SMAD4e+4-9				TTTACAAGAGGGTGTAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60338725627460943					ELAC1	chr18	50967990	50988121	16395				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518739	48518789	50992369	50992419	19491	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-1				ACAATTGCGTGTCTCCCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.045306512242094553					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519090	48519140	50992720	50992770	19492	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-10				GCCCTATAGCCACAGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047067735632225292					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518792	48518842	50992422	50992472	19493	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-11				ATGGGACTGGAATGTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091542115968662838					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518818	48518868	50992448	50992498	19494	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-12				CACAGACTCAGACTGCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26921170172001652					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518958	48519008	50992588	50992638	19495	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-13				GGACTGAAAGAAGACCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27689861704610419					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518611	48518661	50992241	50992291	19496	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-14				ATTAGGCTTATAAAAAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2354793239833652					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518979	48519029	50992609	50992659	19497	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-15				ACAACAGAAAGCCCTGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21782844843603039					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519066	48519116	50992696	50992746	19498	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-16				GTGATCTGAAGGCCCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0951064131233481					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518628	48518678	50992258	50992308	19499	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-17				AAAATAGTGCTAATACTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.482859044483936					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518805	48518855	50992435	50992485	19500	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-18				TGCAGTATGGAGAATGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.269819391559855					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518661	48518711	50992291	50992341	19501	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-19				ACTAAATGAATACACACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40129566382063048					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519054	48519104	50992684	50992734	19502	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-2				TCCCCAAGTTAACCCTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24029789262304641					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519103	48519153	50992733	50992783	19503	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-20				AGCCTCAGGGAAACCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44015837288478321					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519116	48519166	50992746	50992796	19504	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-21				CCTTCCCTGGCCTCCCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36841080733676251					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519009	48519059	50992639	50992689	19505	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-22				AGAGGGAGCAGGCCTTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23688541666160229					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519020	48519070	50992650	50992700	19506	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-23				GCATTCCAGGCAGAGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2198173835455539					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519033	48519083	50992663	50992713	19507	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-24				GAGAGGAGAAAGAGCATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33540650525444748					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519269	48519319	50992899	50992949	19508	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-25				CTCCATATAGCTGGTACTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14114828974681251					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519223	48519273	50992853	50992903	19509	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-26				ACCCAGGAGGCGGAGGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66013935398374046					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519186	48519236	50992816	50992866	19510	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-27				GTTGCCAGGCTAGAGTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.4033316011972454					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519236	48519286	50992866	50992916	19511	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-28				AAGAATCGCTTGAACCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77867399846239849					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519172	48519222	50992802	50992852	19512	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-29				TGGAGTCTCGCTCTGTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3736435842745357					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519130	48519180	50992760	50992810	19513	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-3				AGAGTAATATGCTACCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5859245674793621					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518755	48518805	50992385	50992435	19514	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-4				CTAACTGCCTGTAGCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2794716361527696					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518997	48519047	50992627	50992677	19515	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-5				GTTGTCGCAAAGCCTTTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1142979947440423					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518881	48518931	50992511	50992561	19516	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-6				ACCATTAAGTTTCAAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46472966866446741					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518943	48518993	50992573	50992623	19517	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-7				CTTCTGCAGCCCTAGCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2033733540505776					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519077	48519127	50992707	50992757	19518	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-8				GCTATAGGGCTGTGATCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057698950345354633					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48518921	48518971	50992551	50992601	19519	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5-9				GTGTAGAGGAAGATTAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27624286614673549					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78088	chr18	48519152	48519202	50992782	50992832	19520	hg38	N/A	N/A	N/A	Enhatls83774	enhancer	SMAD4e+5/OCT4e-11				TTTTTTTTTTTTTTTTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4306673015990419					ELAC1	chr18	50967990	50988121	90				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2106
enhrx-78072	chr18	48426075	48426125	50899705	50899755	19521	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-1				GTAACTCACCCAGTGTGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.029074544397110831					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426224	48426274	50899854	50899904	19522	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-10				CTGTGTGTGCTAAGTACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16147115388816649					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426432	48426482	50900062	50900112	19523	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-11				GGGGAAAAGAGGTGTGAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5924568748673541					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426034	48426084	50899664	50899714	19524	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-12				CTGAAAACTTCCTAGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20922053243083519					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426192	48426242	50899822	50899872	19525	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-13				TGAGGATACAGACTAAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52542986510220036					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426365	48426415	50899995	50900045	19526	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-14				TCTAATCCAAACTTATTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.251080893441088					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426279	48426329	50899909	50899959	19527	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-15				GCATAAACAGATGAGCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.044275992896623637					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426061	48426111	50899691	50899741	19528	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-16				GTGGTGAGGAATTAGGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33077627183769143					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426334	48426384	50899964	50900014	19529	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-17				TTTCACAGATAATTAAACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.103143362384305					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426008	48426058	50899638	50899688	19530	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-18				GTCACTGGTGCCAAAGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01273360929342192					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48425993	48426043	50899623	50899673	19531	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-19				TCTTCCATGAAACTGGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12807172966864719					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426140	48426190	50899770	50899820	19532	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-2				TTCCAACTGAGTATGATACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1177336872748256					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426101	48426151	50899731	50899781	19533	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-3				CACAAGAATGCTCAAAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20534433943156011					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426173	48426223	50899803	50899853	19534	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-4				ATGGTCATTGTCCTCAATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.017101542625133071					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426402	48426452	50900032	50900082	19535	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-5				CTAACTTGTTTTACAAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.631224505464135					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426249	48426299	50899879	50899929	19536	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-6				CATCTACCCAGCATGTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22760169406918809					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426309	48426359	50899939	50899989	19537	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-7				AATCTGACATGATTGGTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38066697295245072					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426162	48426212	50899792	50899842	19538	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-8				ATTATCTCATTCCTCCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20535941287640061					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-78072	chr18	48426210	48426260	50899840	50899890	19539	hg38	N/A	N/A	N/A	Enhatls83758	enhancer	SMAD4e+6-9				TACTGTGGGGTAAGATAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28496078959200688					ME2	chr18	50879117	50954257	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2090
enhrx-lit554	chr18	48402856	48402906	50876486	50876536	19540	hg38					enhancer	SMAD4e+7-1				ACACTTTACGTACGTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18364013781171731													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit555	chr18	48402590	48402640	50876220	50876270	19541	hg38					enhancer	SMAD4e+7-10				TGCCCCCTGACCTCCTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47751916638866632													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit556	chr18	48402399	48402449	50876029	50876079	19542	hg38					enhancer	SMAD4e+7-11				TGTATATTTGGTCTCTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02437061486804273													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit557	chr18	48402749	48402799	50876379	50876429	19543	hg38					enhancer	SMAD4e+7-12				GGAGGGTGGTAAGCCAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68799617448938022													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit558	chr18	48402603	48402653	50876233	50876283	19544	hg38					enhancer	SMAD4e+7-13				CTTATCTCCTCTTCCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27011712872965388													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit559	chr18	48402457	48402507	50876087	50876137	19545	hg38					enhancer	SMAD4e+7-14				AAAAGATGCCCCTGTCACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14819362959127941													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit560	chr18	48402809	48402859	50876439	50876489	19546	hg38					enhancer	SMAD4e+7-15				AGCCAGATGGAAGAGATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69129263437358235													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit561	chr18	48402682	48402732	50876312	50876362	19547	hg38					enhancer	SMAD4e+7-16				GTCCTTCTGGAGTTTTATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30465318948508341													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit562	chr18	48402695	48402745	50876325	50876375	19548	hg38					enhancer	SMAD4e+7-17				CTCTTTGAACCCTGTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24274350158325489													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit563	chr18	48402624	48402674	50876254	50876304	19549	hg38					enhancer	SMAD4e+7-18				AGGGTTGAGTTGATCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27720050137091368													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit564	chr18	48402517	48402567	50876147	50876197	19550	hg38					enhancer	SMAD4e+7-19				GGCAACCAGCCCCCATCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.367404552896343													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit565	chr18	48402844	48402894	50876474	50876524	19551	hg38					enhancer	SMAD4e+7-2				CGTTACAAAGGATGTCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85602134396724272													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit566	chr18	48402822	48402872	50876452	50876502	19552	hg38					enhancer	SMAD4e+7-20				GACACAGATGAACAGCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48057542034872341													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit567	chr18	48402501	48402551	50876131	50876181	19553	hg38					enhancer	SMAD4e+7-21				GTGGGCTCCTAGATAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39117725862964142													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit568	chr18	48402469	48402519	50876099	50876149	19554	hg38					enhancer	SMAD4e+7-22				GGGCATCTTTTGTTCTAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28503896260815359													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit569	chr18	48402482	48402532	50876112	50876162	19555	hg38					enhancer	SMAD4e+7-23				TCTAATGAGGCAACTCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32924096958741489													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit570	chr18	48402547	48402597	50876177	50876227	19556	hg38					enhancer	SMAD4e+7-24				CAATCCTCTAATCACATGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1987512045148325													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit571	chr18	48402640	48402690	50876270	50876320	19557	hg38					enhancer	SMAD4e+7-25				TTGATTACATCATTGACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67204329255877626													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit572	chr18	48402668	48402718	50876298	50876348	19558	hg38					enhancer	SMAD4e+7-26				TTATGGAGGCTTCCTTACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050090331288743413													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit573	chr18	48402446	48402496	50876076	50876126	19559	hg38					enhancer	SMAD4e+7-27				CTGTCACTCAGGAAATTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.096399747086315976													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit574	chr18	48402762	48402812	50876392	50876442	19560	hg38					enhancer	SMAD4e+7-28				GGAGCTTCCATGCCCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.575116445608971													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit575	chr18	48402728	48402778	50876358	50876408	19561	hg38					enhancer	SMAD4e+7-3				GCTGAACACGTGAAGGCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1066030296770525													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit576	chr18	48402342	48402392	50875972	50876022	19562	hg38					enhancer	SMAD4e+7-4				CATATGTCACTATATTGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20296738740366091													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit577	chr18	48402788	48402838	50876418	50876468	19563	hg38					enhancer	SMAD4e+7-5				GGGGCACAGTATGTGGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.083468488990203107													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit578	chr18	48402656	48402706	50876286	50876336	19564	hg38					enhancer	SMAD4e+7-6				TAATCAATCACACCTATGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.06984132536483724													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit579	chr18	48402374	48402424	50876004	50876054	19565	hg38					enhancer	SMAD4e+7-7				CTGTGACATTGTGATAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62927570303938019													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit580	chr18	48402424	48402474	50876054	50876104	19566	hg38					enhancer	SMAD4e+7-8				GGATTTAGAAGCTTTTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93746026828326778													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit581	chr18	48402387	48402437	50876017	50876067	19567	hg38					enhancer	SMAD4e+7-9				ATAGAATAGGAATGTATATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.83150721154528													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-78066	chr18	48332695	48332745	50806325	50806375	19568	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-1				TAGGCATCGAAAGTGGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.019446099450549131					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332960	48333010	50806590	50806640	19569	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-10				GTATTAGTTATCTATCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70291843657810282					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48333068	48333118	50806698	50806748	19570	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-11				ATGAAGCCCCTGACAAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38940544956442957					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48333005	48333055	50806635	50806685	19571	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-12				TGGGAGTCTCCACACCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.274969289482498					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332738	48332788	50806368	50806418	19572	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-13				AGAAACCTCTGTCCCACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1490203187095476					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332612	48332662	50806242	50806292	19573	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-14				ACTCTATCTTAGCAGACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3000228186844317					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332673	48332723	50806303	50806353	19574	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-15				ACAGGCCACTCTGTCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13515910727097369					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332632	48332682	50806262	50806312	19575	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-16				AGGAGGCGACACCCTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42117767003369661					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332991	48333041	50806621	50806671	19576	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-17				AGACTCCCAGGGCTGGAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66962811088968877					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332751	48332801	50806381	50806431	19577	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-18				AATTCAGTTACTTCCCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99473607889814608					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48333020	48333070	50806650	50806700	19578	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-19				CAAGGTGGTTGGAGAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25920227936376022					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332891	48332941	50806521	50806571	19579	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-2				ATCTCGGGTTTTCGCGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64164879318155976					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332804	48332854	50806434	50806484	19580	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-20				CTTCAGGAAGGAATGCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36461585809660829					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332865	48332915	50806495	50806545	19581	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-21				TGACCCAGCTGAGCTGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2213404062706236					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332644	48332694	50806274	50806324	19582	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-22				ACTTCCTCCAGGCCAGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2125820872583708					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332844	48332894	50806474	50806524	19583	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-23				CATCTGCTTAGGATCTCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13717896437860769					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332655	48332705	50806285	50806335	19584	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-24				GCAGGCAGCTCACTTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26893848705548662					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48333056	48333106	50806686	50806736	19585	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-25				ACAAGGTAGGGAAGGAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2232063978021365					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332576	48332626	50806206	50806256	19586	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-26				ACTGCAGGCGTGAACCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1093369522958183					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332522	48332572	50806152	50806202	19587	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-27				CTTGAACTCCTGACTTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.098262421700950384					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332561	48332611	50806191	50806241	19588	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-28				TCCCAAAGTGCTGGAACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1234010582399262					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332536	48332586	50806166	50806216	19589	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-29				TTCAAGTGGTCCACCCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058103382676263138					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332931	48332981	50806561	50806611	19590	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-3				GTAAGCTGCTAAGTGTGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35247338283593072					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332550	48332600	50806180	50806230	19591	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-30				AGCACTTTGGGAGGCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9023930082653191					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332907	48332957	50806537	50806587	19592	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-4				GCAACACGTGTTGATTATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49077668675727382					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332777	48332827	50806407	50806457	19593	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-5				GGGTTCGCTTACATCGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31462205072495941					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332943	48332993	50806573	50806623	19594	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-6				GTGTGCGGTGGTTTGTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0867298134854642					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332590	48332640	50806220	50806270	19595	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-7				TCTTATGGGCTGGGCCGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72810490228123848					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332788	48332838	50806418	50806468	19596	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-8				GTAAGCGAACCCTGAGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6446473103882463					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78066	chr18	48332712	48332762	50806342	50806392	19597	hg38	N/A	N/A	N/A	Enhatls83752	enhancer	SMAD4e+8-9				TTTTTGCCTGCTGTATGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34186304626792952					MRO	chr18	50795119	50825402	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2084
enhrx-78063	chr18	48311074	48311124	50784704	50784754	19598	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-1				TGCTTTGTGCTAATCGCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14114603377281271					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311256	48311306	50784886	50784936	19599	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-10				GAGCCATTCTTTCAACAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30485150257031229					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311231	48311281	50784861	50784911	19600	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-11				TAGACTCTCCAGACCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16454317472632771					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48310994	48311044	50784624	50784674	19601	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-12				CAGGTATCTTTCTACTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27901614152721638					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311119	48311169	50784749	50784799	19602	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-13				CATATCTCCAGCCTTTAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53256914698812918					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311363	48311413	50784993	50785043	19603	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-14				GGGTTCTGCACTCACAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34456282537557992					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311215	48311265	50784845	50784895	19604	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-15				CACTTGGAATTCTCACACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.151713179386141					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48310961	48311011	50784591	50784641	19605	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-16				CAGTCCACTCACCTTGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.037552034889200087					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311010	48311060	50784640	50784690	19606	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-17				ATACCTGTGGCCAGAGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75678406377869334					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311448	48311498	50785078	50785128	19607	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-18				AGAATTTGTAGAGGGGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.9084951088627538					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311383	48311433	50785013	50785063	19608	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-19				TGCCAAACATCTCCAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1275568415228614					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311398	48311448	50785028	50785078	19609	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-2				GTTTGGCAGCCAAGGTACCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10435861821184809					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311414	48311464	50785044	50785094	19610	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-20				ACCGGGGCTGTGAAGGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47587053881615188					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311312	48311362	50784942	50784992	19611	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-21				CAAAGCTGCTCAGTGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043617132147446357					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311198	48311248	50784828	50784878	19612	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-22				CAACAGAACAAAGCCTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18012996855255931					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311108	48311158	50784738	50784788	19613	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-23				TTCAACAAATACCCATTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52582472726424823					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311183	48311233	50784813	50784863	19614	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-24				TTCTGTTGCAGGGGAAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8151430957194679					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311464	48311514	50785094	50785144	19615	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-25				AAATTCTTTCTCAGTTACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4194011885208585					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311437	48311487	50785067	50785117	19616	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-26				AGGGGTGAGTGGGGAGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.680764945801775					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311484	48311534	50785114	50785164	19617	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-27				AGGAGGCTGAGGCGGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.396306583644277					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311513	48311563	50785143	50785193	19618	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-28				CTCTATAGCCTCCACCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9730960846278176					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311499	48311549	50785129	50785179	19619	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-29				GAGAGTGGCTTGAGCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9712618562170832					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311275	48311325	50784905	50784955	19620	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-3				GCTCTTAGAGGGTGAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15983006900515759					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311157	48311207	50784787	50784837	19621	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-4				CAAGCCTTTGCTATGAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2059404688653225					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311296	48311346	50784926	50784976	19622	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-5				GGGATGTTGTCGCCCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040983094771102027					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311337	48311387	50784967	50785017	19623	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-6				GTCCCCCCCTCTGACTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16630504482978031					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311058	48311108	50784688	50784738	19624	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-7				GACAAGGCAGTGTAATCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69542942420480458					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48311042	48311092	50784672	50784722	19625	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-8				GCTACTGCTCCCATAGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051565645523501041					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-78063	chr18	48310949	48310999	50784579	50784629	19626	hg38	N/A	N/A	N/A	Enhatls83748	enhancer	SMAD4e+9-9				CTTGGCTTGGGCTGCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14956062125037639					MRO	chr18	50795119	50825402	5205				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2081
enhrx-158917	chr8	55379487	55379537	54466927	54466977	19627	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-1				CGAGTTCTCCGCCGTTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.04159184339025					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379259	55379309	54466699	54466749	19628	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-10				CCTAAGCCACGGTGACTCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.998314693796575					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379292	55379342	54466732	54466782	19629	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-11				ACTTCGCGGTGCACCGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.9198305839468151					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379460	55379510	54466900	54466950	19630	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-12				GGTAGGGATCGGGCGATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.259428595581195					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379864	55379914	54467304	54467354	19631	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-13				GCCGAGTTGCCGAGCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4019189977355579					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379945	55379995	54467385	54467435	19632	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-14				TCTCGCATCCGGCGCCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.288168192298774					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380125	55380175	54467565	54467615	19633	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-15				TGGCGAACATCCTCAAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.93862427036056462					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379321	55379371	54466761	54466811	19634	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-16				TTCCGAAGCCTTGGCGCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10210831388539079					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379512	55379562	54466952	54467002	19635	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-17				GAATCTAAGCTCCCGCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.06278983667798					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379934	55379984	54467374	54467424	19636	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-18				CCAAGGGCGAGTCTCGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1668580056026761					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379183	55379233	54466623	54466673	19637	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-19				GAGCTCAAAACTCCTCGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.937868112152723					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378811	55378861	54466251	54466301	19638	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-2				GTAAGCGGCCCCAATTGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3910331996270029					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379662	55379712	54467102	54467152	19639	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-20				TCGGAGACCCGCGCAGCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.02347536938376					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379171	55379221	54466611	54466661	19640	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-21				GACGTCGCGCGCCCGCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82660516305306053					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379636	55379686	54467076	54467126	19641	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-22				CGAACCGCCACCCGCGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050493837873625692					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379678	55379728	54467118	54467168	19642	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-23				GAGGCACGGAGATGCTCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.266274398666746					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379777	55379827	54467217	54467267	19643	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-24				TCACTGGCGTATCCCGCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	13.8036080101889					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378982	55379032	54466422	54466472	19644	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-25				TGCGGGAGTTCCTCCTGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016235482847716469					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379122	55379172	54466562	54466612	19645	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-26				AAAGATCTTAGGTCTGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.746097905563162					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378826	55378876	54466266	54466316	19646	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-27				GTCACAGCCACGGCGGTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.6099841992487069					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379341	55379391	54466781	54466831	19647	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-28				GAAGTTCTCAGCGGGACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.380448436259285					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380006	55380056	54467446	54467496	19648	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-29				AGCTGGGCGTCAAGCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66529123379640032					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379444	55379494	54466884	54466934	19649	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-3				TAGCCGTCCGCTGCCGGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40935598695364878					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379278	55379328	54466718	54466768	19650	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-30				AAGGTGAGAATGCAACTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.553213481559101					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379236	55379286	54466676	54466726	19651	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-31				AGATGAAGTGCTCGTTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8538618225762209					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379828	55379878	54467268	54467318	19652	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-32				CCGGCGGTGACGGCTAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0906629731605974					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379728	55379778	54467168	54467218	19653	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-33				CGGCGGAGGGTTTCGGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2512498040735956					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379582	55379632	54467022	54467072	19654	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-34				CCGCAGTGTCGCTGGACCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5244333603913669					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380072	55380122	54467512	54467562	19655	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-35				CGGGAACCCCGGACGTGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4115415715345629					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380061	55380111	54467501	54467551	19656	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-36				AACCCGGGCGCCGGGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1112897082721429					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379875	55379925	54467315	54467365	19657	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-37				GAGCTCCCTCGGGGACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8138926916511231					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379000	55379050	54466440	54466490	19658	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-38				GCGGGCGTCTGAGGCGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.3143877142001461					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380100	55380150	54467540	54467590	19659	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-39				CTTCTGCGCGGGGAGACGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64249258503451245					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379071	55379121	54466511	54466561	19660	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-4				TACATTAGGCCGCATTAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.159899702711032					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379057	55379107	54466497	54466547	19661	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-40				ACTCTTCCCGCTGCTACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5452831825342921					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379498	55379548	54466938	54466988	19662	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-41				GCCGCCGGGCTCCACCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.1009314290177579					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379970	55380020	54467410	54467460	19663	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-42				GGGCGAAGGTCGAGCGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.90051519365761					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378971	55379021	54466411	54466461	19664	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-43				GGAACTCCCGCAGCCCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21459502192515831					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379959	55380009	54467399	54467449	19665	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-44				CGACCTTCGCCCCACCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.241920117970484					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380163	55380213	54467603	54467653	19666	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-45				GCTAAACACGAAAGAGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2822053106448561					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378866	55378916	54466306	54466356	19667	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-46				CTTACATCCACTAGGAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1659424274034029					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379571	55379621	54467011	54467061	19668	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-47				GCGACACTGCGGGCGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.3185879528153008					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379038	55379088	54466478	54466528	19669	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-48				GAGTGTAGGTCCCTGGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8140210621282771					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379796	55379846	54467236	54467286	19670	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-49				GTGACTACCAGAGCCAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.346228171387045					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379248	55379298	54466688	54466738	19671	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-5				CGTTTACTCGGCCTAAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.295603903443552					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379815	55379865	54467255	54467305	19672	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-50				TCACCGCCGGCAGCGCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2941719947492678					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379608	55379658	54467048	54467098	19673	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-51				CGCTGGCCACGCCGTGGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018624431463298421					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379134	55379184	54466574	54466624	19674	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-52				TCTGATGGGGGAGTGCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5097991082619131					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379764	55379814	54467204	54467254	19675	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-53				CGCCGTGAGCAGGCCGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2985730083230784					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379027	55379077	54466467	54466517	19676	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-54				CGGAGCGCGCTCCCCTCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72804481311110258					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379922	55379972	54467362	54467412	19677	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-55				CTCGCCCTTGGCTCGGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.35944924965828					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378897	55378947	54466337	54466387	19678	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-56				TTCCCCTTTTATAGGCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72651513154975478					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379407	55379457	54466847	54466897	19679	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-57				GCACGTTCTTTCCTGTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90655451939008214					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380033	55380083	54467473	54467523	19680	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-58				CGCTCCGCCTCCCCCGGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0867682123268521					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379553	55379603	54466993	54467043	19681	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-59				TCAGAAGAGGCCCCGCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.68489553025908656					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379714	55379764	54467154	54467204	19682	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-6				TTTTCCTCCGCGTCCGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02412483997892019					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379625	55379675	54467065	54467115	19683	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-60				GCTGGGACTGGCCCGGAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35384525688696822					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378957	55379007	54466397	54466447	19684	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-61				TCCTGCCCTCGGGTCCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.0717166704984482					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379200	55379250	54466640	54466690	19685	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-62				GAGCTCTTAGCTTGGTGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48834508244550412					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379739	55379789	54467179	54467229	19686	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-63				TTCGGCGCGCGGGGCAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2002850398473628					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378761	55378811	54466201	54466251	19687	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-64				TATATGTAACAGCACTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.456967041812658					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379418	55379468	54466858	54466908	19688	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-65				GGTTTGATTTTCCCCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4628251576460849					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379540	55379590	54466980	54467030	19689	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-66				GGGCCACATGGTCTCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60213747076668767					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379361	55379411	54466801	54466851	19690	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-67				TGGGACAGGCTTTCCTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.774213609937576					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380020	55380070	54467460	54467510	19691	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-68				CGCCCAGCTGCGCCCGACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.78512237003667351					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379842	55379892	54467282	54467332	19692	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-69				TAGGCTGGGCCCCTGTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.86847737276256					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379224	55379274	54466664	54466714	19693	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-7				GCACTTCATCTAGCGCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.904963485401892					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378914	55378964	54466354	54466404	19694	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-70				GGGGAAAGGCTTAGGCGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.602846296471697					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379528	55379578	54466968	54467018	19695	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-71				TAGATTCTCTGTGGGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.05924037543179					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379887	55379937	54467327	54467377	19696	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-72				GGACTTGAAGGTGAAGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	14.184327558566309					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380046	55380096	54467486	54467536	19697	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-73				AGGCGGAGCGCGGGGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75649992003317468					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379898	55379948	54467338	54467388	19698	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-74				TGAAGGGCGAGGCGCCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65627201698327853					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379986	55380036	54467426	54467476	19699	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-75				GGGGGTCCCTCGCCAGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94616760854244286					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380193	55380243	54467633	54467683	19700	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-76				ATATTTAGTGTTTCCCTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22215139532518791					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380089	55380139	54467529	54467579	19701	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-77				GGAGGGCTGGGCTTCTGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99888739092156487					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379305	55379355	54466745	54466795	19702	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-78				CGGCAGGCAGGCCCCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.553641141490822					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379097	55379147	54466537	54466587	19703	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-79				TGGATTCACTTTAATTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3879205803115531					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379853	55379903	54467293	54467343	19704	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-8				CGGCAACTCGGCCCAAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.172036682244302					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379697	55379747	54467137	54467187	19705	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-80				GGAAAAGAAGGTGGTGAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.9602554843478179					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55378940	55378990	54466380	54466430	19706	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-81				GCAGGAGGGTGCGGGGAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3147183066655379					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379372	55379422	54466812	54466862	19707	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-82				TTCCTCTGAGGGAAGAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23037046498286379					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55379111	55379161	54466551	54466601	19708	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-83				TTTAAAAGGTAAAAGATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3770611955091749					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55380144	55380194	54467584	54467634	19709	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-1-9				TCGGAGGTAGAGCCACCGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56787161896811122					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158922	chr8	55618310	55618360	54705750	54705800	19710	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-1				GTTGTTGAGTATGGTCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2348040556296927					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618138	55618188	54705578	54705628	19711	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-10				GTTGTTTGCCTGCAGAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7745571413753588					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617923	55617973	54705363	54705413	19712	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-11				CAGAGGTACTTTCTCAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36542442526735119					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617908	55617958	54705348	54705398	19713	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-12				TACCTCTGCCTTGACTCCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3663486913304923					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618325	55618375	54705765	54705815	19714	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-13				TGTCAAAGTTCTTCTCCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.821917740093411					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617892	55617942	54705332	54705382	19715	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-14				GTGCACTGGTTCTCTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35969321316509267					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618203	55618253	54705643	54705693	19716	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-15				CCACTCAGAAGCTGAGGCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.431893456692624					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617866	55617916	54705306	54705356	19717	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-16				TCTAGGAAAAGCACCAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19526391090953					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618294	55618344	54705734	54705784	19718	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-17				CAACAACACTGAGGTCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17374941027231319					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618167	55618217	54705607	54705657	19719	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-18				CTTGGAGTGTCATGCCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0282712161579041					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618153	55618203	54705593	54705643	19720	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-19				CAAACAACAACACTCCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23655343834560361					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617879	55617929	54705319	54705369	19721	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-2				ACCAGTGCACATTCCATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15525111334436631					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617989	55618039	54705429	54705479	19722	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-20				AGACTCTGAATACCAAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1053984265594292					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617942	55617992	54705382	54705432	19723	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-21				CTGGTGTGTGACAGTATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70731511664998492					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618050	55618100	54705490	54705540	19724	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-22				GTCTCAGTCTCCAGCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01058343034306574					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618039	55618089	54705479	54705529	19725	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-23				GGAGACTGAGACCAGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0243739137995721					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617849	55617899	54705289	54705339	19726	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-24				AGACACATAAGGCAGAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44022348635181358					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617959	55618009	54705399	54705449	19727	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-25				GCATGGAGTATTGCCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23779045768540541					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618260	55618310	54705700	54705750	19728	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-3				CTACACTGCTGAAACTAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72221738734341068					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618023	55618073	54705463	54705513	19729	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-4				CACATGGACTCACTACAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45790443316783858					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618185	55618235	54705625	54705675	19730	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-5				AGTGGTAATCTCTTTACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17851044213644829					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618064	55618114	54705504	54705554	19731	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-6				GTGTTAAGTGACCTCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23154521969659561					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618217	55618267	54705657	54705707	19732	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-7				AGGCGAAGGTCAGACTTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1049570772489295					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55618101	55618151	54705541	54705591	19733	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-8				ATAATGTGACTTAGGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11413920880793781					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55617972	55618022	54705412	54705462	19734	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-10-9				GCTCGGGAAGCTTCCTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48800813601079929					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649249	55649299	54736689	54736739	19735	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-1				GTCTACACATGGAAGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35482841916399871					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649265	55649315	54736705	54736755	19736	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-10				CACAAGACTCTACACTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58040102152541639					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649113	55649163	54736553	54736603	19737	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-11				CTCTACAGATGACAGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44992838141136371					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649292	55649342	54736732	54736782	19738	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-12				CAATGCCCATCCTGCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.09718822906020648					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649187	55649237	54736627	54736677	19739	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-13				CACTTCACAGTAAATGACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74096690085584993					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55648945	55648995	54736385	54736435	19740	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-14				ACGTCACAGAACTAGTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.028140215138555569					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55648984	55649034	54736424	54736474	19741	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-15				TAGGATACTGAGGATTAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01881593745962051					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649135	55649185	54736575	54736625	19742	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-16				GCACCAAGGACTCCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2482026847022635					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649323	55649373	54736763	54736813	19743	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-17				CTTGTTAAACACACAGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.055905820450268241					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649085	55649135	54736525	54736575	19744	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-2				GTGCGCTGCACCTGGTAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29911775532502333					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649003	55649053	54736443	54736493	19745	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-3				TTACCCACCTTGTGCTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043549872017615829					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649238	55649288	54736678	54736728	19746	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-4				GTGGAGATTGGGTCTACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01494689421864096					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649067	55649117	54736507	54736557	19747	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-5				CGCACGGCACACACCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39249114612320041					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649164	55649214	54736604	54736654	19748	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-6				GCTCAGGATATGTTTTCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063151430627813143					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649219	55649269	54736659	54736709	19749	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-7				TTAGATTATTACCTCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2356859377093021					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649049	55649099	54736489	54736539	19750	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-8				TGTGTAGTTTAAAGAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70082283987960059					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55649148	55649198	54736588	54736638	19751	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-11-9				CCTCTGCTGGTAAATGGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28395655633895039					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666608	55666658	54754048	54754098	19752	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-1				TAGTCTGTTGGCATGTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25441221156774863					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666684	55666734	54754124	54754174	19753	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-10				GGGTCTGTGGAGGATTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1168698510775828					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666549	55666599	54753989	54754039	19754	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-11				ATCTATTGTGATAGGAGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79160328644492717					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666455	55666505	54753895	54753945	19755	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-12				TGCTTCCTGGCCTTAGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70875795187289492					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666435	55666485	54753875	54753925	19756	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-13				AGGTGCCACCATTTCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1365146543501104					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666696	55666746	54754136	54754186	19757	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-14				GATTCACTGGGTTGGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.681730878133477					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666619	55666669	54754059	54754109	19758	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-15				CATGTGAAGGGGAAGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81135291358008332					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666636	55666686	54754076	54754126	19759	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-16				AAAGGGAAGGGGCCTTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18367561152823669					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666477	55666527	54753917	54753967	19760	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-17				AGAGGAAATTGAGGAGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.596552703291418					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666667	55666717	54754107	54754157	19761	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-2				AGACCCCTTGTCAGCCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26746456751145359					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666648	55666698	54754088	54754138	19762	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-3				TTGGTGGCTGTTCCACACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.608358864248234					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666574	55666624	54754014	54754064	19763	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-4				AACAATTGTGGGCTTATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17180133486698121					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666500	55666550	54753940	54753990	19764	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-5				GACTTATTTAGAAGATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22868116681868431					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666518	55666568	54753958	54754008	19765	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-6				GCTGGAATCTTAAAAGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73373363838047023					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666563	55666613	54754003	54754053	19766	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-7				GAGGCAAGGCAAACAATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1542370927576083					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666725	55666775	54754165	54754215	19767	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-8				GCCTGCATGTTGGAAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.99654659588063021					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55666592	55666642	54754032	54754082	19768	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-12-9				CAGACTAGCAGAGAACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.056256966549833809					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676684	55676734	54764124	54764174	19769	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-1				GGGGCCCACAATTGTTTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2192013310178276					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676796	55676846	54764236	54764286	19770	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-10				GTGTGGCCAAGGCCAGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00783933262568051					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676533	55676583	54763973	54764023	19771	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-11				ACTTTAAAAGCTTTCCACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87250565466508223					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676695	55676745	54764135	54764185	19772	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-12				ATTGTGGGCCCCCTGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7145998638920279					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676820	55676870	54764260	54764310	19773	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-13				GCAGGCCTACAGCTCAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043071454752614841					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676604	55676654	54764044	54764094	19774	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-14				GCGTGAGTCTGGAGTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21811927493092209					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676843	55676893	54764283	54764333	19775	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-15				CAGAGAAGAAAGTGTCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1043266202004742					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676807	55676857	54764247	54764297	19776	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-16				GTAGGCCTGCTGTGTGGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51975092258879718					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676711	55676761	54764151	54764201	19777	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-17				AGGCAGGTGAGGCAGGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4801655937053983					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676727	55676777	54764167	54764217	19778	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-2				CTTTAGTTTGCCTTGCCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3076951002594519					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676577	55676627	54764017	54764067	19779	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-3				TCCTGAATACCTCTGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28779567383846688					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676547	55676597	54763987	54764037	19780	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-4				ATAGTCTATTCTAGCCATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64591062859413884					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676627	55676677	54764067	54764117	19781	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-5				AGGTGCTGAGGACCGTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.617959195394813					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676759	55676809	54764199	54764249	19782	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-6				TCATCCTTGAGATCACACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.538712951094576					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676784	55676834	54764224	54764274	19783	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-7				GAACCTTTGCAGCCAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044986911408969363					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676615	55676665	54764055	54764105	19784	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-8				CCAGACTCACGCCCTTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52032385095256783					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55676639	55676689	54764079	54764129	19785	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-13-9				CAATTAATAAGAAGGTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1258851048913909					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692558	55692608	54779998	54780048	19786	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-1				AGCTAGGTGATTTTTTTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.03985468903161446					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692534	55692584	54779974	54780024	19787	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-10				AGCCATGTTAACCCACTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50965347845437114					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692233	55692283	54779673	54779723	19788	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-11				TCAATTGGAAGTGTATTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23980007731309769					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692915	55692965	54780355	54780405	19789	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-12				GGTAAGACATATAAACTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2746642583771482					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692352	55692402	54779792	54779842	19790	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-13				TAGTTATTAGTATGTATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3452725442050251					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692298	55692348	54779738	54779788	19791	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-14				ATCTAATTTTTTCCTCTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25204898046137292					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692248	55692298	54779688	54779738	19792	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-15				CCAATTGATAAGAAAACATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33400957520148572					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692152	55692202	54779592	54779642	19793	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-16				AAATGTTATGATCTAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.300796714065638					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692269	55692319	54779709	54779759	19794	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-17				GGAAGGAAACAGTTAATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.27752465437442					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692120	55692170	54779560	54779610	19795	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-18				GTAACAGAATACACAGAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2318559087773739					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692523	55692573	54779963	54780013	19796	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-19				TATTATCTTTACCTTTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-6.0347683685668967					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692882	55692932	54780322	54780372	19797	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-2				TTTACTAATGATTCACTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14463220213305669					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692428	55692478	54779868	54779918	19798	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-20				TGAAAGCATTTCACAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0043760552500735411					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692732	55692782	54780172	54780222	19799	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-21				TTTGTTTATGTATTGTACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5267672822196152					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692486	55692536	54779926	54779976	19800	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-22				TCAGCCACTGAGTTTGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32709305899983449					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692775	55692825	54780215	54780265	19801	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-23				TGAAATTTAATTACAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.2580225857103242					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692821	55692871	54780261	54780311	19802	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-24				GGCCATAGTTTGCCACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23520258757936829					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692401	55692451	54779841	54779891	19803	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-25				ATTTATAAGTAAAAAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692799	55692849	54780239	54780289	19804	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-26				GGCAGGCTGGATTTGGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.389369915878309					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692786	55692836	54780226	54780276	19805	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-27				TACAAAAACAGGTGGCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50671880877875974					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692680	55692730	54780120	54780170	19806	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-28				TAGTTGCAACAGAGACCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.023401987793249389					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692894	55692944	54780334	54780384	19807	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-3				TCATTAGTAAACTCGGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.050311608831083238					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692313	55692363	54779753	54779803	19808	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-4				CTACCAGGGATACATGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.343340477471934					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692380	55692430	54779820	54779870	19809	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-5				ATACCGTTAGCATTTCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40896537256766891					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692660	55692710	54780100	54780150	19810	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-6				TGGCCTGAAAAGCCTAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01509238944398388					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692210	55692260	54779650	54779700	19811	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-7				AAAGCACGGTTGAGTTATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27927032876318392					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692639	55692689	54780079	54780129	19812	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-8				GGCTTATCAGCTGGCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.072190841287025187					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55692833	55692883	54780273	54780323	19813	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-14-9				AGACATCATAGTCCAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2151919110427629					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856677	55856727	54944117	54944167	19814	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-1				GATATCTGCAGACCGATGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1666594260735724					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856964	55857014	54944404	54944454	19815	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-10				TCGGTGGAGAGGGGACGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.005292490097968657					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856751	55856801	54944191	54944241	19816	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-11				TGGCAGGACTGAGCCAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49805150090105588					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55857006	55857056	54944446	54944496	19817	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-12				AGGTGGTCTTTCTCCCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32899643393790928					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856897	55856947	54944337	54944387	19818	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-13				GAGGTTATGCTGAGAATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33816291434533918					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856738	55856788	54944178	54944228	19819	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-14				CCAGCCCATGGCTCCTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51344898586403875					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856878	55856928	54944318	54944368	19820	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-15				TCTCGCATCCAACAAGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9066313834643196					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55857019	55857069	54944459	54944509	19821	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-16				GCCCTGGACCCAGCCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12489480764606729					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856825	55856875	54944265	54944315	19822	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-17				CAAAGAAAGCTGTAACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.093218754936220574					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856867	55856917	54944307	54944357	19823	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-18				TTGGATGCGAGACAAGAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41169553742436149					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856661	55856711	54944101	54944151	19824	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-19				AGATATCCTTTGTAGGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2746342535449765					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856689	55856739	54944129	54944179	19825	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-2				GTTAACATACTTCCAACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49500279764407012					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856620	55856670	54944060	54944110	19826	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-20				ATTCTCAGCAAACTATTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1619522557542019					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856581	55856631	54944021	54944071	19827	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-21				CGCATGTTCTCACTCATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77329925232666619					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856557	55856607	54943997	54944047	19828	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-22				AATTGAACAATGAGAACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2501805008280009					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856545	55856595	54943985	54944035	19829	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-23				AGAACACCTGGACACAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.326196616209784					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856945	55856995	54944385	54944435	19830	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-3				CGGAGCAATGAAACAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25806042812249108					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856782	55856832	54944222	54944272	19831	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-4				GAGGGCAGCCACCCCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15577602289485429					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856769	55856819	54944209	54944259	19832	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-5				TGCCACTGCTTCCCCTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28319827509348361					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856993	55857043	54944433	54944483	19833	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-6				AAGACCACCTGACTTCAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23750199113839091					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856801	55856851	54944241	54944291	19834	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-7				CCTCCAGTGGCAGAAGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25286644475209569					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856726	55856776	54944166	54944216	19835	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-8				TGTTGCCCTGCTCCAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084503190468964248					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55856925	55856975	54944365	54944415	19836	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-15-9				GAGGACAGAGAAGAATTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1318184325667866					RP1	chr8	54559168	54871720	65775				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158923	chr8	56032099	56032149	55119539	55119589	19837	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-1				GCAACTTGGGCGCTCTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.240949776586492					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031872	56031922	55119312	55119362	19838	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-10				GTCTAAGAGTCTCTTCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.440404900693551					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032018	56032068	55119458	55119508	19839	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-11				TGTTGTGTAGAGGGCTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.017049775608091011					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031908	56031958	55119348	55119398	19840	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-12				TTCCCAGCAGGAGTCCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28580030759067943					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031751	56031801	55119191	55119241	19841	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-13				TATAACTGTTTATATCCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38462929613819052					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031844	56031894	55119284	55119334	19842	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-14				CCAGAAGAGACTCTCAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51006412729644035					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032159	56032209	55119599	55119649	19843	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-15				GAGTGTCAGGGGAGGCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66016772597274942					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031921	56031971	55119361	55119411	19844	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-16				CTGCTGGGAAGGTTTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39881460691094789					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031793	56031843	55119233	55119283	19845	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-17				GGGCAGAGAGAATGTAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14998941178222619					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032063	56032113	55119503	55119553	19846	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-18				AGCAGATGAGAAGGGGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0072171427303815783					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032182	56032232	55119622	55119672	19847	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-19				TGAAAATACATGTCTGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091395550895603722					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032123	56032173	55119563	55119613	19848	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-2				ATCCGAAGTTGACTGTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094660285059702892					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031893	56031943	55119333	55119383	19849	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-20				ACTGGGAAGTCCCTCCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.563856787626598					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032029	56032079	55119469	55119519	19850	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-21				GGGCTGAAATGGAAGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.086707028954935622					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031699	56031749	55119139	55119189	19851	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-22				AAATGTGCTCTCTGACTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28011685407782749					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031971	56032021	55119411	55119461	19852	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-23				AATGTTAAGCAGAAAAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.5818653024153291					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031824	56031874	55119264	55119314	19853	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-24				TGGGAGGGACTTCCCAGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.566631180390289					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031766	56031816	55119206	55119256	19854	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-3				TGATAATGCAGGGCACCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67558320117382387					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032146	56032196	55119586	55119636	19855	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-4				AATGCGCAGCAATGAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068706614325984086					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56032086	56032136	55119526	55119576	19856	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-5				GCCAAACTAACCAGCAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57756822196188107					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031732	56031782	55119172	55119222	19857	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-6				TATAAATGGCAGACTCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19030207794672971					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031777	56031827	55119217	55119267	19858	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-7				TCTGCCCTTGCTGATAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69022004060263109					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031812	56031862	55119252	55119302	19859	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-8				TGGGAAGGGACTCCCATACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.057569339562993					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158923	chr8	56031939	56031989	55119379	55119429	19860	hg38	N/A	enh78456	N/A	Enhatls169767	enhancer	SOX17e-16-9				AGAGGTAGGAGCTTTTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79156532703233251					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2714
enhrx-158924	chr8	56285407	56285457	55372847	55372897	19861	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-1				CCAGGGTACTGCTCATACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69100982706812153					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285457	56285507	55372897	55372947	19862	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-10				CATCTGCTCTGACAGTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068260003131055527					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285713	56285763	55373153	55373203	19863	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-11				TCGAAAACTACAAAAACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36114564802661081					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285525	56285575	55372965	55373015	19864	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-12				TTTGTTAGGATAAAATCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07379443750355498					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285470	56285520	55372910	55372960	19865	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-13				AGAGCAGATGCAAGGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15458557907330911					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285390	56285440	55372830	55372880	19866	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-14				AAACAGCTTTTTTCCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1508447889084536					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285373	56285423	55372813	55372863	19867	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-15				CTGTTTTAAAATCCCTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15774604444753829					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285422	56285472	55372862	55372912	19868	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-16				TACACAGGAGGGTATATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.319639042101508					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285729	56285779	55373169	55373219	19869	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-17				CTTTTGGGGTTTTTTTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33676678721868281					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285764	56285814	55373204	55373254	19870	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-18				TCGTCTAGTCGGGAGTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77788380617613628					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285798	56285848	55373238	55373288	19871	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-19				CTCACTGCACCCGCCACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.199423366151416					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285612	56285662	55373052	55373102	19872	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-2				GTGCTGACAAAACCTTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070391353216616256					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285775	56285825	55373215	55373265	19873	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-20				GGAGTACAGTGGCGCGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3931110108804021					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285753	56285803	55373193	55373243	19874	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-3				GACTCACCCTGTCGTCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1799984680810652					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285576	56285626	55373016	55373066	19875	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-4				GCCCTGTCCTTCTGCAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34601807936040507					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285656	56285706	55373096	55373146	19876	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-5				TACAGCTGAGTTATGAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24866911631806771					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285360	56285410	55372800	55372850	19877	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-6				ACCAGGATCACTTCCTACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077259780007528311					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285598	56285648	55373038	55373088	19878	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-7				TTAGCCAGGCAGAGCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056825448972019313					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285492	56285542	55372932	55372982	19879	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-8				GAAGGAGAAGCTGATTCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.052892262412047773					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56285511	56285561	55372951	55373001	19880	hg38	N/A	enh102349	N/A	Enhatls169768	enhancer	SOX17e-17-9				TTGGTATGTAAACGTTTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42823237484539289					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338198	56338248	55425638	55425688	19881	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-1				TTTCTCACGTGGGTAACGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51895738122957					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338095	56338145	55425535	55425585	19882	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-10				GAGGTGACTGTAAGAGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28632489218583052					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338118	56338168	55425558	55425608	19883	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-11				CTGCTTTGAACATACTCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082213151617608074					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338170	56338220	55425610	55425660	19884	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-12				CTCCAACAGATAGAAGATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44468642507158868					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338345	56338395	55425785	55425835	19885	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-13				GTTACAGAGGATCAGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.044713842866566621					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338080	56338130	55425520	55425570	19886	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-14				GTTAAAGGTGAAGATGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14330925563265609					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338037	56338087	55425477	55425527	19887	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-15				AGGCTCAGAAGGATCAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38893870100596772					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338315	56338365	55425755	55425805	19888	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-16				GCCTTGCCACTTCCTGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33587680938268882					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338315	56338365	55425755	55425805	19889	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-16				GCCTTGCCACTTCCTGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33587680938268882					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338390	56338440	55425830	55425880	19890	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-17				TTCTTCAAATCCACCCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74143698537278857					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338370	56338420	55425810	55425860	19891	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-18				GAAGCCTTGAACAGAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45512483033003082					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338245	56338295	55425685	55425735	19892	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-19				TTTGAATGCAGTGAGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1109136633402997					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338209	56338259	55425649	55425699	19893	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-2				GACCACCCAGGTTTCTCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515852					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338327	56338377	55425767	55425817	19894	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-20				AGAGGTATGAGGCCCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8271677013777721					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338327	56338377	55425767	55425817	19895	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-20				AGAGGTATGAGGCCCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8271677013777721					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338232	56338282	55425672	55425722	19896	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-21				AGCTCAGAGGGGGAAGATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060285080886167262					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338358	56338408	55425798	55425848	19897	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-22				AGAGAGAATGGCTGTTACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94307688541005719					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338156	56338206	55425596	55425646	19898	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-23				AGATACAGGGGAGGAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41417211150660349					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56337990	56338040	55425430	55425480	19899	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-3				CGATGACAACTACTACCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1204604941629084					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338221	56338271	55425661	55425711	19900	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-4				GGAAGATTATGGGACCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40262217549777313					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338005	56338055	55425445	55425495	19901	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-5				TCTAATAATTATCAGCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031323477734435667					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338276	56338326	55425716	55425766	19902	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-6				ATGAGCTTGACACAGTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.414236587382195					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338403	56338453	55425843	55425893	19903	hg38	N/A	N/A	N/A	Enhatls169768	enhancer	SOX17e-18-7				TGCTCTGATGTCTCCATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32667314864388658					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56337975	56338025	55425415	55425465	19904	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-8				TGTCATCGAGATGATGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26249240382183953					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158924	chr8	56338057	56338107	55425497	55425547	19905	hg38	N/A	enh78462	N/A	Enhatls169768	enhancer	SOX17e-18-9				AAGTAGCATGTGATAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39304459449784918					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2715
enhrx-158925	chr8	56433579	56433629	55521020	55521070	19906	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-1				GGCTCGCGCCAACCAAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21362465053286039					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433657	56433707	55521098	55521148	19907	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-10				AGGAGGCCGGCGTGAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45067962559356478					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433624	56433674	55521065	55521115	19908	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-11				TGGGGCACAGCGCCGCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1713493710378349					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433643	56433693	55521084	55521134	19909	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-12				CGGCCTCCTTCAGCACAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23682835562025081					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433490	56433540	55520931	55520981	19910	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-13				TTACTATTTTTTCACTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37422294232597769					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433673	56433723	55521114	55521164	19911	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-14				GGAAGGGGAGGGGCGTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1808376281113569					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433777	56433827	55521218	55521268	19912	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-15				CATAAGAAGAGAGATATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72902286624267076					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433712	56433762	55521153	55521203	19913	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-2				CGCCGCGTTTAAAAGCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1842302599835654					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433600	56433650	55521041	55521091	19914	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-3				AGATAACTGCACCGCCGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095761023590096958					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433564	56433614	55521005	55521055	19915	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-4				AAGCGGGGTTGTTAACGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35009402732144662					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433750	56433800	55521191	55521241	19916	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-5				AGAAGCTACACGTTTGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41151648321213868					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433527	56433577	55520968	55521018	19917	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-6				TAACGTCTTCCTGTGCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10522529211324121					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433689	56433739	55521130	55521180	19918	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-7				TCCCGGGCAGAAACCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.74857158467774					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433808	56433858	55521249	55521299	19919	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-8				TTAATTTCGACGCTTTTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.037773412551979441					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158925	chr8	56433612	56433662	55521053	55521103	19920	hg38	N/A	enh78465	N/A	Enhatls169769	enhancer	SOX17e-19-9				TGCAGTTATCTTCCTGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63886802194777093					XKR4	chr8	55102027	55542054	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2716
enhrx-158917	chr8	55383006	55383056	54470446	54470496	19921	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-1				AGTTCACGCGCATGGCGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6316387764378032					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382994	55383044	54470434	54470484	19922	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-10				TGGCGCCGGGGGTCGCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55047701328124732					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383236	55383286	54470676	54470726	19923	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-11				CTGTCAGTCTTAGTAATACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.852093513599303					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383141	55383191	54470581	54470631	19924	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-12				GGAGACTCCGCTGGCTGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87663257470697342					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382933	55382983	54470373	54470423	19925	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-13				TGCGCTTAGCTGCTGGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85070558304938215					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382799	55382849	54470239	54470289	19926	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-14				TGTGCGGGGCAGCGACCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97709720990310422					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383032	55383082	54470472	54470522	19927	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-15				GGCGACGGGCTCGCCCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48823428302463712					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382747	55382797	54470187	54470237	19928	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-16				CGCGTAGCCCTGGGCGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2661534867643921					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383211	55383261	54470651	54470701	19929	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-17				AGCTGGTAACGCAACTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1552689901832021					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383188	55383238	54470628	54470678	19930	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-18				CGACTTCAACCTCTCTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29367651922046561					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382689	55382739	54470129	54470179	19931	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-19				CGCGGGGATCTTGCGGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.655622946356051					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382689	55382739	54470129	54470179	19932	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-19				CGCGGGGATCTTGCGGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.655622946356051					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382866	55382916	54470306	54470356	19933	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-2				ACGCGGTCAAACGGGGACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1733923918860609					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382556	55382606	54469996	54470046	19934	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-20				TGTGTGGGGCGCCTCTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42271997759723451					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382625	55382675	54470065	54470115	19935	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-21				CAACTGGGTACCCAGCGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99261523820434483					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383070	55383120	54470510	54470560	19936	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-22				TCCAGATGCAGCCGCCGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72407647301052724					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383122	55383172	54470562	54470612	19937	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-23				TGGGGTCAGCGCCGTCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0383528999096321					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382587	55382637	54470027	54470077	19938	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-24				AAGCGCAGACATCTCCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86559186638494523					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382599	55382649	54470039	54470089	19939	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-25				TGTCTGCGCTTTGTGAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32024997966722979					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382883	55382933	54470323	54470373	19940	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-26				AGGCGGGGTCCGGCTCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0232920636649094					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382707	55382757	54470147	54470197	19941	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-27				GACGGTCCTGGTCTCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95799706864246159					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382707	55382757	54470147	54470197	19942	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-27				GACGGTCCTGGTCTCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95799706864246159					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382970	55383020	54470410	54470460	19943	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-28				GCCCGCAGCCCCCTCATCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20542879175195511					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382779	55382829	54470219	54470269	19944	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-29				AGGAGGGAAAGCCCTGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.85374417919975509					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382730	55382780	54470170	54470220	19945	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-3				TACGCGGCCGCGAACGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29360227848258341					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382730	55382780	54470170	54470220	19946	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-3				TACGCGGCCGCGAACGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29360227848258341					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383046	55383096	54470486	54470536	19947	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-30				ACCGCGCGCGCCGCCCGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42095164582712569					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382542	55382592	54469982	54470032	19948	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-31				CTGGGTGATAAAAGTGTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68763267306263554					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383084	55383134	54470524	54470574	19949	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-32				CGGCGTCAGCTGCCCCGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39071543792141938					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382666	55382716	54470106	54470156	19950	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-33				CTGCGCCGCCTCCCGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1722056042771391					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383269	55383319	54470709	54470759	19951	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-34				ATATTCCTGTCTTTCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1197895206746724					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382572	55382622	54470012	54470062	19952	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-35				TTGCAGGCTTCCTGTCCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64706548650598728					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382636	55382686	54470076	54470126	19953	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-36				TCCTCCTGCGCCCACCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0073557650901159					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382768	55382818	54470208	54470258	19954	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-37				GGCCTGCCCTTCCCCGCGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71069903977712978					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382610	55382660	54470050	54470100	19955	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-38				TGTGAGTTTGGGAAACAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9625055251547654					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382850	55382900	54470290	54470340	19956	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-39				ACGCAGGGCGTGGGCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12800799829650969					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383173	55383223	54470613	54470663	19957	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-4				TGAAGTCGGCACCGGCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18399683001270711					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382899	55382949	54470339	54470389	19958	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-40				CAGCGCGGGGCGAGGAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15544629501541621					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383156	55383206	54470596	54470646	19959	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-41				GAGTCTCCTGGGAACAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.17793692562167579					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382655	55382705	54470095	54470145	19960	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-42				AGGAGGAGCTGCCTTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0042719780369827676					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382922	55382972	54470362	54470412	19961	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-43				GCTGGTGCGGGGCAGGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.156048834830904					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382981	55383031	54470421	54470471	19962	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-44				CGCCAGTAGGCCCAGCGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.548028115704553					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382839	55382889	54470279	54470329	19963	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-45				GGGCAGTGGTGGCAGTGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21386145954030669					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383018	55383068	54470458	54470508	19964	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-5				GCGCGTGAACTGTGGGCGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4958628189790511					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382813	55382863	54470253	54470303	19965	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-6				TACGACCAGAGCCATGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1311462129463144					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382719	55382769	54470159	54470209	19966	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-7				GAACGGTTGGGGGACGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9277436935934471					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382719	55382769	54470159	54470209	19967	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-7				GAACGGTTGGGGGACGGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9277436935934471					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55382523	55382573	54469963	54470013	19968	hg38	N/A	enh100804	N/A	Enhatls169761	enhancer	SOX17e-2-8				CCACTCACACTGTGTTCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.94842610242277026					SOX17	chr8	54457934	54460892	5134				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55383110	55383160	54470550	54470600	19969	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-2-9				CGTCCAGCAGGGCGCGTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.62035104501262794					SOX17	chr8	54457934	54460892	9284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158945	chr8	56757541	56757591	55844982	55845032	19970	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-1				GGTCTTCTCAGTGTCTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34435260778073051					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757846	56757896	55845287	55845337	19971	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-10				CCAGGAGTGCTGATTGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49984278259589537					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757938	56757988	55845379	55845429	19972	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-11				GAGGAGCCAGTTTATCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.084291519554443264					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757734	56757784	55845175	55845225	19973	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-12				GAGCTGGCTGTGCGGGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0621839821395817					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757648	56757698	55845089	55845139	19974	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-13				GCGGGCAACGTGAACCCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81898433853193719					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757680	56757730	55845121	55845171	19975	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-14				AGAGCCGATTCATCAAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47968511864784891					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757828	56757878	55845269	55845319	19976	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-15				TGGAGGGAAGCCAGTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14693563197467119					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757859	56757909	55845300	55845350	19977	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-16				TTGGTCAGGGATGAAATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38230743424613739					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56758010	56758060	55845451	55845501	19978	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-17				ACTGATCTCAGGAGCAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30717741311308361					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757999	56758049	55845440	55845490	19979	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-18				ATATCTCAAGCACTGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3253629998898902					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757976	56758026	55845417	55845467	19980	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-19				TTTGCAGACCCTGCACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4722178002942688					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757581	56757631	55845022	55845072	19981	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-2				TTGCATCACCCAACCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0041941719040658916					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757718	56757768	55845159	55845209	19982	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-20				AAGAGTAATTCACGCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1088754054482387					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757667	56757717	55845108	55845158	19983	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-21				AATCGGCTCTGTCTAGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.435741727052921					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757632	56757682	55845073	55845123	19984	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-3				ACTCTAAATATAACTGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54731991167962224					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757919	56757969	55845360	55845410	19985	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-4				CGTAGGGGCCACAAGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32252550490437493					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757568	56757618	55845009	55845059	19986	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-5				ACCACTTCCCTCCCCACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67608738470234964					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757800	56757850	55845241	55845291	19987	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-6				CAAGTTATCCTTAAAAATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1649436464936628					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757898	56757948	55845339	55845389	19988	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-7				CGCAGGAACTGACTCAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.046511389642359423					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757783	56757833	55845224	55845274	19989	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-8				TTCTGGTCGCTGAATGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.039642470510540317					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56757812	56757862	55845253	55845303	19990	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-20-9				AGGATAACTTGGTAGGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13677109244739441					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760842	56760892	55848283	55848333	19991	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-1				CTCGTTAAGCGAGTTACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40139089606480849					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760546	56760596	55847987	55848037	19992	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-10				ATTCTTAATCTCCCCGCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26084794832620722					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56761036	56761086	55848477	55848527	19993	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-11				GTCCCGGTGCTGAAGTCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32365568995422972					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760935	56760985	55848376	55848426	19994	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-12				AACCAAGGGAAGCTTCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1233995026527962					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760685	56760735	55848126	55848176	19995	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-13				AAACCTACACTTATCTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.97658022188317328					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760772	56760822	55848213	55848263	19996	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-14				AGACCATAGGAAGATTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19025630329237339					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56761025	56761075	55848466	55848516	19997	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-15				CAGCACCGGGACTTGCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25964466375888379					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760986	56761036	55848427	55848477	19998	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-16				AGCTCTTCTCTGAGGTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0358115111225633					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760627	56760677	55848068	55848118	19999	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-17				TCTGGAGAGTGTATGGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48432735880407107					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760571	56760621	55848012	55848062	20000	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-18				GAGTCATGAGGAATCGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44529941467966577					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760786	56760836	55848227	55848277	20001	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-19				TTTCAAAGGGAAACCCCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3555768702324536					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760800	56760850	55848241	55848291	20002	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-2				GGATACCGTGATATCCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.485452740184567					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760739	56760789	55848180	55848230	20003	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-20				ACAGCAATCAATGAGATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25005670025562943					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760759	56760809	55848200	55848250	20004	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-21				TGTTTTTGGTCTCAGACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58389206513167813					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760534	56760584	55847975	55848025	20005	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-22				AGATTAAGAATTCAGACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.242992320685649					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760263	56760313	55847704	55847754	20006	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-23				TTCTGTCCCTCTGTCCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3286234301051183					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760661	56760711	55848102	55848152	20007	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-24				TGGCTTCAAGGGACAGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.3410354037391459					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760921	56760971	55848362	55848412	20008	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-25				AGAAAAACTCCACAAACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.131897275504925					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760592	56760642	55848033	55848083	20009	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-26				GGGTTGGAGAGATAGTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75371686770945179					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760952	56761002	55848393	55848443	20010	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-27				AATGCCCTGCCCTTCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25205111246082129					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760715	56760765	55848156	55848206	20011	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-28				AGGAAGAGAAGCTGCATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20506326083901449					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760317	56760367	55847758	55847808	20012	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-29				GGAGTGAACCCGGAAGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2093026231255628					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56761073	56761123	55848514	55848564	20013	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-3				TTTGCTCTGCTAGCGACTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12215186327346809					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760521	56760571	55847962	55848012	20014	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-30				AGACTGTGGGCCGGGCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760445	56760495	55847886	55847936	20015	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-31				TCAGGAGATCGAGACCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0138960381759461					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760240	56760290	55847681	55847731	20016	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-32				TTTTTTTTTGAGACGGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34714777801928842					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760483	56760533	55847924	55847974	20017	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-33				ACCTCGGCCTTCCAAAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73418771521914372					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760468	56760518	55847909	55847959	20018	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-34				GCCGAGGTGGGCGGATCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1791438149903239					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760395	56760445	55847836	55847886	20019	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-35				AAAAATACAAAAATATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7454641934940369					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760431	56760481	55847872	55847922	20020	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-36				TTTCACCATGTTAGCCAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.68656137968682762					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760277	56760327	55847718	55847768	20021	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-37				TGCGTCACTGCACTCCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39088188935225809					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760382	56760432	55847823	55847873	20022	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-38				TATTAGCCGGGCGTGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73915190093349448					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760355	56760405	55847796	55847846	20023	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-39				TGTAGTCCCAGCTACTCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2938718904177984					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760876	56760926	55848317	55848367	20024	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-4				CCCCGTGAATGTGAACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23028489952309569					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760338	56760388	55847779	55847829	20025	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-40				GGGAGGCTGAGGCAGGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7209636201629439					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760408	56760458	55847849	55847899	20026	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-42				TTGTATTTTTAGTAGAGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.254526706171582					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56761084	56761134	55848525	55848575	20027	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-5				AGCGACTGGGGGCTTTTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071502784818258572					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760898	56760948	55848339	55848389	20028	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-6				GAGTTCTGCGGAACGAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036162693967565072					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760830	56760880	55848271	55848321	20029	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-7				GTTACAATGGGAAGCTGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.99881787338709616					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760650	56760700	55848091	55848141	20030	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-8				GAACCCTGTGATGGCTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79124740887046574					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56760557	56760607	55847998	55848048	20031	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-21-9				TCATGACTCAGCCTGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76982885185120709					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764406	56764456	55851847	55851897	20032	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-1				AGTAGAACAGATCGGGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00085635430807010646					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764525	56764575	55851966	55852016	20033	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-10				AGATTATGGAACAGTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52592376124972218					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764525	56764575	55851966	55852016	20034	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-10				AGATTATGGAACAGTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52592376124972218					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764391	56764441	55851832	55851882	20035	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-11				GAGGTGGGGGGCGCAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46721986173046243					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764339	56764389	55851780	55851830	20036	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-12				GCACATTGCTGAAGAAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67454771090580357					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764339	56764389	55851780	55851830	20037	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-12				GCACATTGCTGAAGAAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67454771090580357					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764419	56764469	55851860	55851910	20038	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-13				CTGTTCTACTCTTCATTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58340507136563247					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764448	56764498	55851889	55851939	20039	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-14				TATCTGATTGGCTGTGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35867994252998919					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764321	56764371	55851762	55851812	20040	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-15				CAATGGCCTTATCTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24177283363471411					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764321	56764371	55851762	55851812	20041	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-15				CAATGGCCTTATCTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24177283363471411					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764579	56764629	55852020	55852070	20042	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-16				TATGGAGTTTGAGTGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63209575356099246					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764604	56764654	55852045	55852095	20043	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-17				TTCCTCAGAAAAGACCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11102226057885289					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764375	56764425	55851816	55851866	20044	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-18				TCAGAGGATTTTTGTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.323662520459263					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764460	56764510	55851901	55851951	20045	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-2				ATCACTGCCGTCTATCTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61668152373666041					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764478	56764528	55851919	55851969	20046	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-3				GTGATCAGCTACAATCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28928948608725769					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764506	56764556	55851947	55851997	20047	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-4				ATGGTCTGCCCCTTACAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39960650462421332					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764506	56764556	55851947	55851997	20048	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-4				ATGGTCTGCCCCTTACAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39960650462421332					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764548	56764598	55851989	55852039	20049	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-5				CAATCCTCATGGTAGGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.481646719695793					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764304	56764354	55851745	55851795	20050	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-6				GGATGTTGCTGCTCAAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.030206275962043321					TGS1	chr8	55773445	55826445	14400				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764360	56764410	55851801	55851851	20051	hg38	N/A	enh25007	fant29574	Enhatls169789	enhancer	SOX17e-22-7				GCCTACTTCCTGGAACCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05253074632092837					TGS1	chr8	55773445	55826445	25354				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764559	56764609	55852000	55852050	20052	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-8				AGGAGATGTTACAATCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35355256775973593					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158945	chr8	56764590	56764640	55852031	55852081	20053	hg38	N/A	enh25007	N/A	Enhatls169789	enhancer	SOX17e-22-9				TCAAACTCCATATCCCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.76315414505106349					LYN	chr8	55879834	56014169	24399				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2736
enhrx-158957	chr8	56960733	56960783	56048174	56048224	20054	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-1				GTAATCATACAATGGAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50046142263863591					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960545	56960595	56047986	56048036	20055	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-10				ACCCTTATAAAAGAGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48413595163438572					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960603	56960653	56048044	56048094	20056	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-11				TGAGGCCTTTGGGAGGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87233047443620659					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960640	56960690	56048081	56048131	20057	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-12				GATCCTAACCCCCAAGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39261449020065159					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960515	56960565	56047956	56048006	20058	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-13				GGGATTACAGGCAGGAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60197663089466946					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960461	56960511	56047902	56047952	20059	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-14				GGTCTGGAACTCATGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51068833412405823					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960494	56960544	56047935	56047985	20060	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-15				GCCTTGGCCTCCCAAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29764051824871829					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960478	56960528	56047919	56047969	20061	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-16				CTCAGGTGATCCACCCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.891501257592721					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960713	56960763	56048154	56048204	20062	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-2				TACAGCACAATCTATTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27935342042256439					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960744	56960794	56048185	56048235	20063	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-3				ATGGAATCCTGGGTAATCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25024127713834571					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960561	56960611	56048002	56048052	20064	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-4				TAAGGGTGTGAATTCCATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.097815770112630582					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960532	56960582	56047973	56048023	20065	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-5				AGGCTCCAGGCCGAGCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16053382859163179					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960614	56960664	56048055	56048105	20066	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-6				TATAATGGAGATGAGGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.623010484618591					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960652	56960702	56048093	56048143	20067	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-7				GGGTTAGGATCTCAACATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74731447065378342					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960580	56960630	56048021	56048071	20068	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-8				GTCATGAGGGTGGAGTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13660866662891641					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158957	chr8	56960629	56960679	56048070	56048120	20069	hg38	N/A	enh73264	N/A	Enhatls169801	enhancer	SOX17e-23-9				CCATTATAATACCATCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72964541405274552					RPS20	chr8	56067253	56074510	17147				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2748
enhrx-158917	chr8	55388971	55389021	54476411	54476461	20070	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-1				GAGCCGCCCGAAGACCTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15401114093560139					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388716	55388766	54476156	54476206	20071	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-10				GTGCTGTCAGATAGAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48501113802852858					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388893	55388943	54476333	54476383	20072	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-11				AGATCACTGGACTTCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75747747166832369					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388904	55388954	54476344	54476394	20073	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-12				GTCCAGTGATCTCCAAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0027696634791727561					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388814	55388864	54476254	54476304	20074	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-13				CTCCTCTAGTGGGAAATTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10747893188408709					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388554	55388604	54475994	54476044	20075	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-14				GGTGTCAATATGGAGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25997464459835318					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388417	55388467	54475857	54475907	20076	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-15				TCAACTCTGTAATTGATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5233341547094017					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388768	55388818	54476208	54476258	20077	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-16				CTATCTGACCCAAGATATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41050432426794009					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388579	55388629	54476019	54476069	20078	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-17				GAGGCAAAGCCCCATTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1623270539263785					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388494	55388544	54475934	54475984	20079	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-18				ATTAATTGATCTTGATCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3270061634192139					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388590	55388640	54476030	54476080	20080	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-19				TGTAATTGATGCCAGATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.328056482302958					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389086	55389136	54476526	54476576	20081	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-2				TGGAAGTTTATTACCAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27389522664560229					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388672	55388722	54476112	54476162	20082	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-20				TAAGGGAAGGTTCTAGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54153143599610809					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388783	55388833	54476223	54476273	20083	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-21				TATAATGGAACTTCAGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38038865749734779					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388985	55389035	54476425	54476475	20084	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-22				AACTCGGGTTCTGTCCTCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1575114236382491					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388471	55388521	54475911	54475961	20085	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-23				TCTAACTGGAAGTTCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67549915997411358					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388862	55388912	54476302	54476352	20086	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-24				CATGCGTGCAGGGGTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83383709033450526					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388829	55388879	54476269	54476319	20087	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-25				TAGAGGAGGGGGATGCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63550647218688572					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388609	55388659	54476049	54476099	20088	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-26				TACAGTTCTGCTCAGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1243710719507103					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388685	55388735	54476125	54476175	20089	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-27				CTCAGTAATAGGATAAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.096972146440669					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388636	55388686	54476076	54476126	20090	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-28				AATGTCAAGTGTGGGAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32277614232307927					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388341	55388391	54475781	54475831	20091	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-29				GAGTTCTGAAACTTTGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16016439954333669					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388937	55388987	54476377	54476427	20092	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-3				AAGTAGGGGGCGCATCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.785872704773397					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388950	55389000	54476390	54476440	20093	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-30				TCTGTCTCTCTCTAAGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.595392392326733					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388384	55388434	54475824	54475874	20094	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-31				TGTCTAGGTTGGCCTTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1758514681889162					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388372	55388422	54475812	54475862	20095	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-32				GAACTGTTGCTACCAGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.084640399891790424					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388916	55388966	54476356	54476406	20096	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-33				GGGTCTGTGTGCCCTGTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.022769515699470961					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388399	55388449	54475839	54475889	20097	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-34				GTTGATAAGAGATGCTGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059537012623441292					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388624	55388674	54476064	54476114	20098	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-35				GGGAAGTCAGGCATCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064794564234812					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389049	55389099	54476489	54476539	20099	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-36				AGCCAATGCTGGTGTGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90600276454624229					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389066	55389116	54476506	54476556	20100	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-37				AGGTGGAGTCAGTTCTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22216473180678981					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388880	55388930	54476320	54476370	20101	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-38				TCTCTGGAGGAGGAGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5129924491092287					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389024	55389074	54476464	54476514	20102	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-39				AGAGGGTCTGAGGATGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32912009970928618					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389005	55389055	54476445	54476495	20103	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-4				GTTCACCAGTCAATGAACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.016302233513436949					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388659	55388709	54476099	54476149	20104	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-40				TAGGGTCTGGGGGAGGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.8841295902959529					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389099	55389149	54476539	54476589	20105	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-5				ATGGACGTCGCAGCCGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3125784185483535					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388741	55388791	54476181	54476231	20106	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-6				GGACAACACCCAATGTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1006048687290267					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388851	55388901	54476291	54476341	20107	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-7				GGTGCTGGAAACATGCGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024952379098738819					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55388698	55388748	54476138	54476188	20108	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-8				TATTACTGAGCATTAGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1461116310341613					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55389038	55389088	54476478	54476528	20109	hg38	N/A	enh66556	N/A	Enhatls169761	enhancer	SOX17e-3-9				AGACCCTCTGCAGCCAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21108704111534091					SOX17	chr8	54457934	54460892	14870				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432934	55432984	54520374	54520424	20110	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-1				GTTAGTAGGTTCAAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31660301322576739					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432826	55432876	54520266	54520316	20111	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-10				CTGGATACAACTTACCTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15180204092678121					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432522	55432572	54519962	54520012	20112	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-11				TTACTTAGATAAAAATGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0231304537798387					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432974	55433024	54520414	54520464	20113	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-12				AATCTGTTTGAATAATGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20688776653254179					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432599	55432649	54520039	54520089	20114	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-13				ACAGACACATTGATATATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72519375153325749					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432653	55432703	54520093	54520143	20115	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-14				AATGTTCAAAATGCATGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01252112144984862					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432921	55432971	54520361	54520411	20116	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-15				AAGCAGCAGGCACAAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59519459293086685					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432505	55432555	54519945	54519995	20117	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-16				AAGTAATTATGTGTTATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.8893072481921509					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55433000	55433050	54520440	54520490	20118	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-17				CCAATAAAGGGACTGGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28063192084200772					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432783	55432833	54520223	54520273	20119	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-18				TACCAGGAGGCAGTTATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.228185895944282					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432796	55432846	54520236	54520286	20120	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-19				ATAGGGAGGGGGTTACCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41252204708957563					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432860	55432910	54520300	54520350	20121	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-2				GCACTGTCCATGTAGGATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.063571725029756235					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55433017	55433067	54520457	54520507	20122	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-20				TGTGTTGGGAGAGGGATCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.9317022813480009					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432472	55432522	54519912	54519962	20123	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-21				TTGAAAAGAAGAATCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29213653034816067					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432555	55432605	54519995	54520045	20124	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-22				GAGATAGAGAAATAGATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81882205750333448					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432950	55433000	54520390	54520440	20125	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-3				TACTAACTAAAACTCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92329129976147883					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432903	55432953	54520343	54520393	20126	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-4				CTCTCAGTCACGGTGTGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80025701956930761					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432849	55432899	54520289	54520339	20127	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-5				GTAGGATATGGGGATCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.085089985767461					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432988	55433038	54520428	54520478	20128	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-6				ATGTCCTGGACTCCAATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044479275562272609					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432744	55432794	54520184	54520234	20129	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-7				CAACACTGAGCAACTGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.020194106302825161					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432721	55432771	54520161	54520211	20130	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-8				GAGTGGGGGGAGCATAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44226332771041571					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55432808	55432858	54520248	54520298	20131	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-4-9				TCCAGCTGTCCCATAGGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3735562095285752					SOX17	chr8	54457934	54460892	27044				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464284	55464334	54551724	54551774	20132	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-1				AAGACTCGCCTTCCAGATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28585721341215731					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464507	55464557	54551947	54551997	20133	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-10				AGGCAAACACAATAAGGACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46195480906316821					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464636	55464686	54552076	54552126	20134	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-11				GACACGCTCAGCAGGTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97373601670186372					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464547	55464597	54551987	54552037	20135	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-12				GAGCCACAGGATTGTCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1155610471720412					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464459	55464509	54551899	54551949	20136	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-13				AGACATTGACTTTTCACAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0430639256305849					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464525	55464575	54551965	54552015	20137	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-14				CGAGGTGAGCAGCCACTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1721041994768237					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464471	55464521	54551911	54551961	20138	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-15				AGTCAATGTCTGGGTTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0857216273133351					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464382	55464432	54551822	54551872	20139	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-16				GCATGAGCATCAGTGCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16302073777553611					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464562	55464612	54552002	54552052	20140	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-17				AGATCAGGTCTGCTTCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27728691529209287					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464620	55464670	54552060	54552110	20141	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-18				GCGTGTCTTCTGTGCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14163512520096039					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464654	55464704	54552094	54552144	20142	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-19				GCAGGTGACATAAAGCCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73441913627367472					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464296	55464346	54551736	54551786	20143	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-2				TTGGCAGAGCTACCTTGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.288112856276853					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464350	55464400	54551790	54551840	20144	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-20				GGGAAGAGGCGAGCTCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32488014460530262					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464577	55464627	54552017	54552067	20145	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-21				ATCAAGAGAAAGCCAAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72263079724205048					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464448	55464498	54551888	54551938	20146	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-22				TTTCACAGGGGGAAATGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88051153215569078					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464315	55464365	54551755	54551805	20147	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-23				CAGAGGCACTGAGGGAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7638164448335637					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464487	55464537	54551927	54551977	20148	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-24				TGTGAGGGTTTAGGAAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92222889924407758					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464259	55464309	54551699	54551749	20149	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-25				TTTTTTTCCATAATGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77566231124151319					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464606	55464656	54552046	54552096	20150	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-3				TGCTATCAGCGTCTCCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081098724815888548					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464419	55464469	54551859	54551909	20151	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-4				TAGGAAATGACCCGCTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1115129257029559					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464394	55464444	54551834	54551884	20152	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-5				GATGCTCATGCGCCACAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1424321845397451					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464332	55464382	54551772	54551822	20153	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-6				GGAGGACCGCACTCATGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44014249315344289					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464406	55464456	54551846	54551896	20154	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-7				GCTTTGAAGGCTCCATCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12576328832444991					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464370	55464420	54551810	54551860	20155	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-8				GTGCAGCTCGGGACTGCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23977259113695751					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55464245	55464295	54551685	54551735	20156	hg38	N/A	enh78449	N/A	Enhatls169761	enhancer	SOX17e-5-9				GTTTCCAGGTAAAATCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19662934188493381					RP1	chr8	54559168	54871720	5174				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475852	55475902	54563292	54563342	20157	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-1				GGGACACGCTCACTCTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16801785454286111					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475695	55475745	54563135	54563185	20158	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-10				ACTCTTCTGCTCTGAGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5139092003664375					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475832	55475882	54563272	54563322	20159	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-11				ACCACACAGGAAATTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49893378021989238					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55476009	55476059	54563449	54563499	20160	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-12				AATATCAAGCACCTCTGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07585414519335934					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475912	55475962	54563352	54563402	20161	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-13				TGAGTGGAGGGCAGCGAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1147433383678703					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475817	55475867	54563257	54563307	20162	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-14				TGTGTGGTCAAGGGAACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41937887073983271					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475636	55475686	54563076	54563126	20163	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-15				GAAGAGCTGATTTAGGCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.072614639892928032					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475998	55476048	54563438	54563488	20164	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-16				ATAAAATATCTCCCTTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22639963520497339					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475937	55475987	54563377	54563427	20165	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-17				ACTGAGCCGAGAAGATGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14067320448810849					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475707	55475757	54563147	54563197	20166	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-18				AGCAGAAGAGTCAGCCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31569052761724142					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475623	55475673	54563063	54563113	20167	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-19				AGGCTTGAGGAACAGATGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24645142147385141					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475559	55475609	54562999	54563049	20168	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-2				ATCTTTGACTGCTGTAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091942543811458055					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475981	55476031	54563421	54563471	20169	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-20				TTTTATCTACATCACATATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7302161762591319					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475737	55475787	54563177	54563227	20170	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-21				CCTGGTCTCAGGCTCCACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49291477825865021					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475757	55475807	54563197	54563247	20171	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-22				TGGCTGCTGGTGGCTTCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5989683507563071					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475787	55475837	54563227	54563277	20172	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-23				AGATTGGGAACAGGCTGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.08284141522023318					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475877	55475927	54563317	54563367	20173	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-24				TCCTCAGAGCCTCTCTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.004485652441399271					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475726	55475776	54563166	54563216	20174	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-25				AGGGCTGGCTTCCTGGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16251621700613531					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475900	55475950	54563340	54563390	20175	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-26				AAAGACTGGCAGTGAGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40339595064642941					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475653	55475703	54563093	54563143	20176	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-27				CTCTTCAGAGAGAGAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46142212736398869					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475965	55476015	54563405	54563455	20177	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-3				TATGTGGACATGGGTACCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5481714816668235					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475534	55475584	54562974	54563024	20178	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-4				CTACCAGGGGCCTCAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18881574610314339					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475547	55475597	54562987	54563037	20179	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-5				TGTAGGACTGGGCCTACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6428683093150009					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475585	55475635	54563025	54563075	20180	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-6				TAAGAGTCTACAGTCATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72326263186974959					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55476039	55476089	54563479	54563529	20181	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-7				GTAAGCCATTCAAAATGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.064922326191030527					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475949	55475999	54563389	54563439	20182	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-8				CTCGGCTCAGTTACCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30504242335496962					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55475772	55475822	54563212	54563262	20183	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-6-9				TCCTAAGGAGATCTGAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4910746132968854					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481089	55481139	54568529	54568579	20184	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-1				ACCTTTAGTGTGATAAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95809308498062851					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481209	55481259	54568649	54568699	20185	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-10				AAGTTGGGTGTGAACAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.128466281793413					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481280	55481330	54568720	54568770	20186	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-11				AAGGTGAAAATGAAGTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19688637075651291					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481280	55481330	54568720	54568770	20187	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-11				AAGGTGAAAATGAAGTGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19688637075651291					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481267	55481317	54568707	54568757	20188	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-12				TTTTCACCTTACAATGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35502240167278271					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481267	55481317	54568707	54568757	20189	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-12				TTTTCACCTTACAATGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35502240167278271					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481406	55481456	54568846	54568896	20190	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-13				GAAATCACTGGCATTATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051622451751376988					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481434	55481484	54568874	54568924	20191	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-14				TGGTCATACAAAAAAACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44973456401344891					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481384	55481434	54568824	54568874	20192	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-2				CTCCAGTTCCCTCATGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0651528485607375					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481156	55481206	54568596	54568646	20193	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-3				TGTCCTTGCCCAGAGTAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064750683852682164					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481057	55481107	54568497	54568547	20194	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-4				TCCTACTCCATTTTTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.082684063152528714					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481343	55481393	54568783	54568833	20195	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-5				TCCTCCACATAGTCACCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.165329217898204					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481186	55481236	54568626	54568676	20196	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-6				GCTTGTGCTCTTTTATCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.777816973865533					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481355	55481405	54568795	54568845	20197	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-7				TCACCACAGGGGACAAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84877046568095371					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481249	55481299	54568689	54568739	20198	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-8				CAAGTTCCCTAGTATGTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42212923780909312					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481303	55481353	54568743	54568793	20199	hg38	N/A	N/A	N/A	Enhatls169761	enhancer	SOX17e-7-9				TGATGAATGAGAACAATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18560198502608841					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158917	chr8	55481303	55481353	54568743	54568793	20200	hg38	N/A	enh95289	N/A	Enhatls169761	enhancer	SOX17e-7-9				TGATGAATGAGAACAATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18560198502608841					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2708
enhrx-158918	chr8	55505504	55505554	54592944	54592994	20201	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-1				AGGGGTCTAAACCGATCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46286600007646139					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505640	55505690	54593080	54593130	20202	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-10				CTAAAGGGGGAAACTAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.86454994167046839					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505303	55505353	54592743	54592793	20203	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-11				TACACTAAGGACAACCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35526366787706731					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505571	55505621	54593011	54593061	20204	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-12				CTCTATGAGGAAGTCATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45500554636876211					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505557	55505607	54592997	54593047	20205	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-13				CTCATAGAGGCTAGAAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35519900086655848					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505655	55505705	54593095	54593145	20206	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-14				CCCTTTAGAATGACAGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024404083740892011					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505467	55505517	54592907	54592957	20207	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-15				GAAGCTCCTTTCTTGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58234101396461					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505599	55505649	54593039	54593089	20208	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-16				GCTTGAGAATGTGCCAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.032714049091655158					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505316	55505366	54592756	54592806	20209	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-17				AATTACAAGTTAATACACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2635145272230162					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505365	55505415	54592805	54592855	20210	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-18				TAGAACACAGAAGTAATACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2475202552323206					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505725	55505775	54593165	54593215	20211	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-19				ATATTTGCCAGTTGCTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19973720004306941					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505515	55505565	54592955	54593005	20212	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-2				CCGATCAGCTGGCCCCCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.4013160853521121					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505484	55505534	54592924	54592974	20213	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-20				AGCTTCTCTTTTGTCAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.137924977292433					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505415	55505465	54592855	54592905	20214	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-21				ATAAGAGGAACAGACACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30312671039137651					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505376	55505426	54592816	54592866	20215	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-22				TTCTGTGTTCTAGGCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14027162632061341					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505430	55505480	54592870	54592920	20216	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-23				ACTTTTGCTTTCTTGATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32239017277895732					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505701	55505751	54593141	54593191	20217	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-24				TATTCATTGCTGTCTCTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26774690598098422					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505390	55505440	54592830	54592880	20218	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-25				CAGGAAGGGGGAAAATGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.629061979782807					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505612	55505662	54593052	54593102	20219	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-3				GCACTGGGTATCACCTAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22103305028429349					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505340	55505390	54592780	54592830	20220	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-4				TCATGCTTGTTGCCCCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091037969338992636					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505528	55505578	54592968	54593018	20221	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-5				CTAATCACTGATGCCTGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30461297636548967					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505539	55505589	54592979	54593029	20222	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-6				ATCAGTGATTAGGAAGTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49973346294458548					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505352	55505402	54592792	54592842	20223	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-7				TAATACCTGGAGCCACTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.081727654548316347					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505627	55505677	54593067	54593117	20224	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-8				CTAATCATGGGATAGGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083724492859368546					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158918	chr8	55505668	55505718	54593108	54593158	20225	hg38	N/A	N/A	N/A	Enhatls169762	enhancer	SOX17e-8-9				CAGTTCTTGGGGTCGGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20603080806056129					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2709
enhrx-158922	chr8	55545572	55545622	54633012	54633062	20226	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-1				CTATGCGCTGCCAAAAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07082453065488882					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545495	55545545	54632935	54632985	20227	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-10				GATATGTAGAATTCAGTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52210220907236671					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545506	55545556	54632946	54632996	20228	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-11				TTCAGTCTCTGGTCCCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20305216917492					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545705	55545755	54633145	54633195	20229	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-12				TTCTTCCGGGTTTAATATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16882147111188189					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545620	55545670	54633060	54633110	20230	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-13				AGGCAATGCTTTAAGCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.219116883111707					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545541	55545591	54632981	54633031	20231	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-14				ATTGTGTTTTGCCCACCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12554953008159381					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545657	55545707	54633097	54633147	20232	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-15				GCTTTCTTTGAAGCAGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22287365092989639					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545600	55545650	54633040	54633090	20233	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-2				TGAGAGGCTTGCATGGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.003348131909084891					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545470	55545520	54632910	54632960	20234	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-3				GTGTAGCCTCCCTTACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.654973178774064					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545556	55545606	54632996	54633046	20235	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-4				CGCATAGCACAGCTGCCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.044588750911827388					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545519	55545569	54632959	54633009	20236	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-5				TAATTTCACCACTCCACCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44282781730001308					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545449	55545499	54632889	54632939	20237	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-6				ACTTCCATACTCAGCCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20860153410640589					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545677	55545727	54633117	54633167	20238	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-7				AGCTGAATGCCCAACTGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33002852005526789					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545584	55545634	54633024	54633074	20239	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-8				AAAAGTTCAGGCACTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32700201958247122					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158922	chr8	55545435	55545485	54632875	54632925	20240	hg38	N/A	N/A	N/A	Enhatls169766	enhancer	SOX17e-9-9				TTAGAGATGAAGTACCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080498947792979225					RP1	chr8	54559168	54871720	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2713
enhrx-158915	chr8	55366827	55366877	54454267	54454317	20241	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-1				ATTTATAAATCGTGCGCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36170301656312143					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit582	chr8	55366710	55366760	54454150	54454200	20242	hg38					enhancer	SOX17e+1-10				CCGGGACGCGAGGTGCGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.2355954806804643													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit583	chr8	55367328	55367378	54454768	54454818	20243	hg38					enhancer	SOX17e+1-11				CGTTAGCACTGCACGGTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.4978088674727665													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366885	55366935	54454325	54454375	20244	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-12				GCCCGTGGATGACTAGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6807868121125464					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit584	chr8	55367555	55367605	54454995	54455045	20245	hg38					enhancer	SOX17e+1-13				AAGGCTCCACACACCGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.797725242162536													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366921	55366971	54454361	54454411	20246	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-14				GAGTGCGCGCCGCAAACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6414813156808084					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit585	chr8	55366696	55366746	54454136	54454186	20247	hg38					enhancer	SOX17e+1-15				GCGTCCCGGCGCCGTCTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6706167381832069													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366972	55367022	54454412	54454462	20248	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-16				AGGCAGATCCGGGTTGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.298128296824955					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit586	chr8	55367191	55367241	54454631	54454681	20249	hg38					enhancer	SOX17e+1-17				CGCTGACCAAAGGCCCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4613630971520708													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit587	chr8	55367517	55367567	54454957	54455007	20250	hg38					enhancer	SOX17e+1-18				CACTTTAATACGTGGTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5483991453632413													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit588	chr8	55367256	55367306	54454696	54454746	20251	hg38					enhancer	SOX17e+1-19				AGCCTTTAGAGCCTCGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.8174759429082057													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367152	55367202	54454592	54454642	20252	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-2				CGGGTAGGTGGCGAACCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3586665274831384					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit589	chr8	55367205	55367255	54454645	54454695	20253	hg38					enhancer	SOX17e+1-20				AGCTGTGCCCGTTGCCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3132412509505844													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit590	chr8	55367568	55367618	54455008	54455058	20254	hg38					enhancer	SOX17e+1-21				CGACGTCGCTGACCCGCGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6653084035126824													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit591	chr8	55366668	55366718	54454108	54454158	20255	hg38					enhancer	SOX17e+1-22				GTTAAAGGTATCAAGGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.15777871253626													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366789	55366839	54454229	54454279	20256	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-23				CAGCACGAGGTGGCGCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1917085138784032					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit592	chr8	55366685	55366735	54454125	54454175	20257	hg38					enhancer	SOX17e+1-24				GCGCGGCACCGCCGCCTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0448887657790551													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit593	chr8	55366751	55366801	54454191	54454241	20258	hg38					enhancer	SOX17e+1-25				GGTCCCGCACCTCCCAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.7980295364264265													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit594	chr8	55367271	55367321	54454711	54454761	20259	hg38					enhancer	SOX17e+1-26				GGGTCCGGCCCAAGGACCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80051711356660316													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367014	55367064	54454454	54454504	20260	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-27				GGAAGGACACTCAAGTCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4801906545847991					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55366983	55367033	54454423	54454473	20261	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-28				CGTGGGCACCTAGGCAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0576576264850956					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit595	chr8	55367415	55367465	54454855	54454905	20262	hg38					enhancer	SOX17e+1-29				TCAACACAAGAGATTTACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2946198975871122													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367000	55367050	54454440	54454490	20263	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-3				GTCGATCGGGAAGGACCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.0311746472146943					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55366801	55366851	54454241	54454291	20264	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-30				ACCTCGTGCTGGCCTCCGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6749691459926259					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit596	chr8	55366653	55366703	54454093	54454143	20265	hg38					enhancer	SOX17e+1-31				GGACAAGGAGGAGACGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.844274370698809													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367074	55367124	54454514	54454564	20266	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-32				AAGGCTGGGTGATTTCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9695133732518091					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55367053	55367103	54454493	54454543	20267	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-33				GGCTTTTGTGTTTTCGATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56710038098140214					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55366956	55367006	54454396	54454446	20268	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-34				GCGCTGGAGAGCAAGTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4798932233970961					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit597	chr8	55367460	55367510	54454900	54454950	20269	hg38					enhancer	SOX17e+1-35				AAAGCAGCAAACATCCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.1304629118216987													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367042	55367092	54454482	54454532	20270	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-36				TTTCGATGCTGGGAAAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2071130315621121					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55367092	55367142	54454532	54454582	20271	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-37				GCCTTTGCCTGGTCACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.81656298666261862					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit598	chr8	55366739	55366789	54454179	54454229	20272	hg38					enhancer	SOX17e+1-38				CCGGCTGCGCTGCCCTACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.2451840719795975													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366813	55366863	54454253	54454303	20273	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-39				CGCGGGCGGCTGCCTCCCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.7226879866335523					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55367171	55367221	54454611	54454661	20274	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-4				GCGGGCGCAGAAATTAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5503234946776807					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55367140	55367190	54454580	54454630	20275	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-40				GAACCGTGGGGCTGACCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.05049707395019					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55366772	55366822	54454212	54454262	20276	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-41				CGGCGGTGGAGCGCGGCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.582589056058477					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158915	chr8	55366910	55366960	54454350	54454400	20277	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-42				GCAAACCCTGGGAAAACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.5406438896231416					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit599	chr8	55367595	55367645	54455035	54455085	20278	hg38					enhancer	SOX17e+1-43				TATTTCGGGGGGCAGTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0197012156229217													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit600	chr8	55367481	55367531	54454921	54454971	20279	hg38					enhancer	SOX17e+1-44				TTACATGTGGCATCTGTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8271426536895756													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit601	chr8	55367446	55367496	54454886	54454936	20280	hg38					enhancer	SOX17e+1-45				AGGCTTGCAGGAAGCCACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.562444894042347													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit602	chr8	55367313	55367363	54454753	54454803	20281	hg38					enhancer	SOX17e+1-46				GTCCAGGGTCGCAGGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.2459710074695334													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366857	55366907	54454297	54454347	20282	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-47				CTGAACAAAGAACAACAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.234977451659605					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit603	chr8	55367426	55367476	54454866	54454916	20283	hg38					enhancer	SOX17e+1-48				CTCTTGTGTTGAGAAAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2176953765548859													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55366944	55366994	54454384	54454434	20284	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-49				AAGTCTGTGGGGGCGGGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.568403898943723					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit604	chr8	55367339	55367389	54454779	54454829	20285	hg38					enhancer	SOX17e+1-5				GCAGTGCTAACGCACCCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.67218005616763													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit605	chr8	55367536	55367586	54454976	54455026	20286	hg38					enhancer	SOX17e+1-50				AGTGAAGAGACTGAAATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.8526324207870886													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367031	55367081	54454471	54454521	20287	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-51				GGAAAGCAGGGGCTGGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.7202506800285589					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-lit606	chr8	55367295	55367345	54454735	54454785	20288	hg38					enhancer	SOX17e+1-6				CGTGAGCGCAATTAGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48765285633176181													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit607	chr8	55367498	55367548	54454938	54454988	20289	hg38					enhancer	SOX17e+1-7				GGCTGGCTCTGATAACGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	9.8194533613363451													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit608	chr8	55367354	55367404	54454794	54454844	20290	hg38					enhancer	SOX17e+1-8				ACACCGCTCGCATAGCCGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6823291107120548													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-158915	chr8	55367115	55367165	54454555	54454605	20291	hg38	N/A	N/A	fant29563	N/A	enhancer	SOX17e+1-9				TCAGAGCCACGCTTATCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3772962615443021					SOX17	chr8	54457934	54460892	3320				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2706
enhrx-158914	chr8	55138004	55138054	54225444	54225494	20292	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-1				ACATCACCAGTCGAGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1559794783496731					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137985	55138035	54225425	54225475	20293	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-10				GGGGATGGGTCCCACGCTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8678463003999979					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137333	55137383	54224773	54224823	20294	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-11				CTACACTGATGGTTGCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7890039583844422					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137845	55137895	54225285	54225335	20295	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-12				TGTTGGAGGCGCAAGACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7971211254183368					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138231	55138281	54225671	54225721	20296	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-13				CATACCTGATCAGAGAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0708383648497342					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137575	55137625	54225015	54225065	20297	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-14				GCAAAGCAACCCTCTAAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5909250344473889					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137772	55137822	54225212	54225262	20298	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-15				CCAAGACATTGTTTGAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6360800164686531					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137362	55137412	54224802	54224852	20299	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-16				TATGTAATTCAGACCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9723746010771461					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137963	55138013	54225403	54225453	20300	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-17				GAGGTTATTTGTGGGCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1038544383828568					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137344	55137394	54224784	54224834	20301	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-18				ACATATAGTTACTACACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4114377597117029					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137551	55137601	54224991	54225041	20302	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-19				CAGATTGACCCCCAGTGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7337277381341312					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137467	55137517	54224907	54224957	20303	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-2				GCATCAGTCTCGGGCTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.996049101872853					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137206	55137256	54224646	54224696	20304	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-20				TACATGGAGTGACCCAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6011320624056151					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137167	55137217	54224607	54224657	20305	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-21				TTCCAGCACTTCCTATTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.588336878824407					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138145	55138195	54225585	54225635	20306	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-22				CTGGAAGACCCTTGAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.907972116123533					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137665	55137715	54225105	54225155	20307	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-23				GAACCTACACAGATAAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.7268367709037982					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137708	55137758	54225148	54225198	20308	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-24				GTGGCTTCTTGCAGGTATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4692995365678629					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138070	55138120	54225510	54225560	20309	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-25				CTTTGCAAGGCACATGCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.783777575040749					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137265	55137315	54224705	54224755	20310	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-26				ACACATTGTCAGACAAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6552511243734791					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137429	55137479	54224869	54224919	20311	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-27				TGGTGAAATTCAGACTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31595531307837338					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138187	55138237	54225627	54225677	20312	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-28				CAAAATCCATGCTAGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0284746291511242					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137195	55137245	54224635	54224685	20313	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-29				ACCCAGTGCAGGTACCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.515643806368637					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137974	55138024	54225414	54225464	20314	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-3				ACAAATAACCTCCAGTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9600892031168549					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137599	55137649	54225039	54225089	20315	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-30				GTGATGCCACCTGCAGAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.4565275673766251					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137235	55137285	54224675	54224725	20316	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-31				CGGGGTCACTCATCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2606350500911319					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137156	55137206	54224596	54224646	20317	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-32				CTCTTTAATCACCTCACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6365750152507921					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137829	55137879	54225269	54225319	20318	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-33				GATCTGGATCTTCTAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.62899848292952					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137805	55137855	54225245	54225295	20319	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-34				CTATTAATCTTCATACAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2979327401223428					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137248	55137298	54224688	54224738	20320	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-35				ATGTGTCCAAAACCCAGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6627295205323742					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138255	55138305	54225695	54225745	20321	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-36				CTTTTCCCACTGGGGAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2752096591029791					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137513	55137563	54224953	54225003	20322	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-37				TGATGACTTTGTTCAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0758817274948469					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137375	55137425	54224815	54224865	20323	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-38				GTCCATTCACCTCCCAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.413753340165627					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137720	55137770	54225160	54225210	20324	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-39				CAAGAAGCCACTGTAAGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8997807001965308					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137540	55137590	54224980	54225030	20325	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-4				GATTAGGTGGCCCCTAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5004670324870308					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137527	55137577	54224967	54225017	20326	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-40				AGAGACAGGCATTGATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.677773480132652					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137125	55137175	54224565	54224615	20327	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-41				AGTATGTTCCCCATCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0970968091274189					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137442	55137492	54224882	54224932	20328	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-42				AATTTCACCAAGTGCCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2969339875610868					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137296	55137346	54224736	54224786	20329	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-43				ATGACATGATTAAGGACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.48576146885306					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137652	55137702	54225092	54225142	20330	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-44				GTGTAGGTTCTGTCCAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6375868181307438					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137181	55137231	54224621	54224671	20331	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-45				GTGCTGGAAGGCGACCAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.243022069315519					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138270	55138320	54225710	54225760	20332	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-46				AATACTGGAAAGGTGGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.836446960614678					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137915	55137965	54225355	54225405	20333	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-47				TATAAAGTGTTGAAAGTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.981849084311426					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138169	55138219	54225609	54225659	20334	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-48				ACTTGCTTATTTTGTGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24734853487088551					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138083	55138133	54225523	54225573	20335	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-49				AATGAAGTCAGTGCTTTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0983588279636					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137222	55137272	54224662	54224712	20336	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-5				AGTGACCCCGTGCAGGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.605571047104891					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137862	55137912	54225302	54225352	20337	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-50				ATAATCAGATTTCATTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35937472303995038					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138126	55138176	54225566	54225616	20338	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-51				TGCCTCTCTCCCCACTGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.5159079087552678					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137611	55137661	54225051	54225101	20339	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-52				GCAGAGTTGGGACAATGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.87076686580254					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137140	55137190	54224580	54224630	20340	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-53				TAAAGAGAAGGAAAACCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.2171400996876778					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137478	55137528	54224918	54224968	20341	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-54				GGGCTTCACAGGCAGAGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7412022347917908					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55138047	55138097	54225487	54225537	20342	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-55				GAGGAGCACAGAGCAAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4502501125349938					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137403	55137453	54224843	54224893	20343	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-6				GTGATAACACTGAACAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8114359835994089					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137456	55137506	54224896	54224946	20344	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-7				CGAGACTGATGCAACCTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.304354500853155					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137639	55137689	54225079	54225129	20345	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-8				TGAGACCTGCAACCCTAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6394240265594768					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55137945	55137995	54225385	54225435	20346	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+10-9				CCCTTTGTTACACACTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00523611797592125					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158895	chr8	54898309	54898359	53985749	53985799	20347	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-1				AGCGTGTTCTTGCTAAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.137996255443211					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898125	54898175	53985565	53985615	20348	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-10				TCAGCAGGAGCTACCTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47251475170328289					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898295	54898345	53985735	53985785	20349	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-11				AAGCACCGGGAAAGGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28048619978654632					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898047	54898097	53985487	53985537	20350	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-12				TCTGGTCACACAGTTCCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.90283531171938314					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898036	54898086	53985476	53985526	20351	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-13				TGTGTGACCAGAGAGACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020550746219736269					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898147	54898197	53985587	53985637	20352	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-14				GCTCTTCTTCTCTGCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36876685063597492					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898062	54898112	53985502	53985552	20353	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-15				TCTCTTCTCAGAGACCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1317044666937379					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898265	54898315	53985705	53985755	20354	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-16				TACTGTGTGTGAGTAGGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.556957898195471					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898254	54898304	53985694	53985744	20355	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-17				AGTAGGGGCAGGGAGCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.037745486642205742					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898098	54898148	53985538	53985588	20356	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-18				GGGGAGGAGAGGAACCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3280540884177121					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898352	54898402	53985792	53985842	20357	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-19				AGGTGACTGTGTGTGCTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19846563699114619					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898376	54898426	53985816	53985866	20358	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-2				GTGAAGACTTCTCAGTTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1018024332609342					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898114	54898164	53985554	53985604	20359	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-20				AGCTCCTGCTGAGCTGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81611063358761438					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898221	54898271	53985661	53985711	20360	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-3				ACATGAGATTGTCCTGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20332587854333509					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898192	54898242	53985632	53985682	20361	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-4				GAACAGCTCCCTTCCTAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0056831206373456318					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898085	54898135	53985525	53985575	20362	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-5				ACCCTCACGGCCATGCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23922439164655329					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898176	54898226	53985616	53985666	20363	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-6				GCTGTTCCAGGGTTCAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17807924548633119					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898277	54898327	53985717	53985767	20364	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-7				CACACACAGTACCCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30113863906085658					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898209	54898259	53985649	53985699	20365	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-8				ATAAGGCCATTTCCTCAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48523098468557369					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158895	chr8	54898332	54898382	53985772	53985822	20366	hg38	N/A	N/A	N/A	Enhatls169739	enhancer	SOX17e+11-9				TCCTCTGGGATAATGAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1774809152394054					TCEA1	chr8	53966551	54022448	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2686
enhrx-158873	chr8	54679129	54679179	53766569	53766619	20367	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-1				CTCCCATTTGCTTTTAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80522748728936278					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679430	54679480	53766870	53766920	20368	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-10				TTAATTTCGCCTTAGTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04775231375347655					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679198	54679248	53766638	53766688	20369	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-11				GAGAATGCGCACCTAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.061425079479980722					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679210	54679260	53766650	53766700	20370	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-12				CTAGGGGTAGGTCTCTGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73557157084989322					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679471	54679521	53766911	53766961	20371	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-13				GAATATCACAAGGCCAGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.63499769604964529					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679080	54679130	53766520	53766570	20372	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-14				TCACCAGTGGTCAGAGTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1623336892975					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679042	54679092	53766482	53766532	20373	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-15				CAGGATAATAGCAATTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50795672814620374					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679355	54679405	53766795	53766845	20374	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-16				GACAGGGTTTTGAGATCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1096210168975389					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679289	54679339	53766729	53766779	20375	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-17				CAGTCTCCCATAGCGTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37572288157820671					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679578	54679628	53767018	53767068	20376	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-18				GCTGGTTTTTGTGGCTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43616976497401527					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679526	54679576	53766966	53767016	20377	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-19				AGGGAGTGTGCGAATAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052282479882655712					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679458	54679508	53766898	53766948	20378	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-2				TGATCTTGCCCTGCCTCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27148920848170988					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679304	54679354	53766744	53766794	20379	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-20				TTCCCAGGCTTATTAGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1637277479231241					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679546	54679596	53766986	53767036	20380	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-21				TTAGGGAGTTTCAAAAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3056473823120669					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679560	54679610	53767000	53767050	20381	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-22				ACTCCCTAATAAAAACTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.106663758515718					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679446	54679496	53766886	53766936	20382	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-23				GGGCAAGATCACAGGACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44417101232278861					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679384	54679434	53766824	53766874	20383	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-24				TAAGATGTTATCAATGACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1301746307856145					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679372	54679422	53766812	53766862	20384	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-25				ATAACATCTTATCAGGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25724822521583018					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679409	54679459	53766849	53766899	20385	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-26				AAAATTGCTAATGAAGTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2154019566716199					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679327	54679377	53766767	53766817	20386	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-3				AAATTCCTGCCTAATAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5822254231819179					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679161	54679211	53766601	53766651	20387	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-4				TGAATTCTTTTTCTCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11362905506514839					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679233	54679283	53766673	53766723	20388	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-5				GAGACAGGTACACCCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21101684070423149					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679221	54679271	53766661	53766711	20389	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-6				TCTCTGAACTGGCCCCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27916131874848821					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679500	54679550	53766940	53766990	20390	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-7				ACAGACATCAAGTTCTTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56451108960105489					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679248	54679298	53766688	53766738	20391	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-8				CAGTCTCAACCATAAGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0191548378410551					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158873	chr8	54679093	54679143	53766533	53766583	20392	hg38	N/A	N/A	N/A	Enhatls169717	enhancer	SOX17e+12-9				TGTTCTGCCCTGCTCACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55901477835309688					ATP6V1H	chr8	53715542	53843558	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2664
enhrx-158870	chr8	54405395	54405445	53492835	53492885	20393	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-1				TGATACCCGACGCCTTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76586477917153117					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405144	54405194	53492584	53492634	20394	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-10				GAGGTAGGGCAAACAAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46378091533623239					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405128	54405178	53492568	53492618	20395	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-11				CTACCTCCCGTTGCTTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077438539516916469					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405552	54405602	53492992	53493042	20396	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-12				CAATATGTGTGGTTGTAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30531867851542449					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405274	54405324	53492714	53492764	20397	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-13				GGTGCAGACTCTGGATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26431342538537139					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405511	54405561	53492951	53493001	20398	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-14				AACATTGCTGAAGCCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28938070549908868					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405383	54405433	53492823	53492873	20399	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-15				GACTCAGGCTGTCCAGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25787847499792482					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405084	54405134	53492524	53492574	20400	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-16				GCGGTGGAAGAGGTCACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2120315099523068					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405169	54405219	53492609	53492659	20401	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-17				GGGCTAGTTTAAATAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73609893229327739					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54404986	54405036	53492426	53492476	20402	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-18				TTAATGCACAATCTTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72114562295556073					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405371	54405421	53492811	53492861	20403	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-19				CAGCCTGAGTCACCTTGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34377807837552249					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405473	54405523	53492913	53492963	20404	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-2				CACCACGCCTATCAGTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13167031047844091					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405301	54405351	53492741	53492791	20405	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-20				TCCTGAAGTGTGCTTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1295088347315709					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405044	54405094	53492484	53492534	20406	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-21				GGAGTCCCCATGTGGCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24745399314664149					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405541	54405591	53492981	53493031	20407	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-22				ATACAAATTCACAATATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.503889186471372					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405431	54405481	53492871	53492921	20408	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-23				TGTTAAAGTATCAAGTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1783822650684019					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405007	54405057	53492447	53492497	20409	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-24				AAACTCACAGATCCCAAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39978662527549669					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405239	54405289	53492679	53492729	20410	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-25				CAGAGTGTGAGAGCCAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66277219092847728					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405359	54405409	53492799	53492849	20411	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-26				GGAGGCGGGAGGCCAAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.114257568449472					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405251	54405301	53492691	53492741	20412	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-27				GCCAGATAAGGGAGGTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.080606413433931					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405345	54405395	53492785	53492835	20413	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-28				AGGGTGGTGATGAGGGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56235470957069555					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405113	54405163	53492553	53492603	20414	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-29				TCCCTTGGAAACCATAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.95692681791409639					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405207	54405257	53492647	53492697	20415	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-3				GGTATGGTGATAACGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.58588595355323847					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405102	54405152	53492542	53492592	20416	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-30				GTGGGCAAGAGCCTTTATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7014039245523298					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405029	54405079	53492469	53492519	20417	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-4				GGAACGTGCATCACACCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1278245894926093					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405445	54405495	53492885	53492935	20418	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-5				GTTTATAGGTGCTACAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15055951420878541					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405187	54405237	53492627	53492677	20419	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-6				ACCAGATACCAGATAGCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22837705367779709					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405066	54405116	53492506	53492556	20420	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-7				ACCGCCTTCTCAGCGACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1179588257671489					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405326	54405376	53492766	53492816	20421	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-8				AGGACTCCTCTTGATGTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.265995439045213					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54405497	54405547	53492937	53492987	20422	hg38	N/A	enh66552	N/A	Enhatls169714	enhancer	SOX17e+13-9				CCATGACATATATTCCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19980345914070841					ATP6V1H	chr8	53715542	53843558	214208				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199607	54199657	53287047	53287097	20423	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-1				CACTCTCTCCCGAATAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19910746679868979					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199371	54199421	53286811	53286861	20424	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-10				TGTCTTACAGAAGCTGCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0072581814580186289					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199465	54199515	53286905	53286955	20425	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-11				CTCACCTCCAGTGCCTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28886934623063792					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199453	54199503	53286893	53286943	20426	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-12				CTGGAGGTGAGAGGGGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34806750038359568					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199286	54199336	53286726	53286776	20427	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-13				TGGAGTGCAGTGGCGTGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0154376438921819					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199310	54199360	53286750	53286800	20428	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-14				AGAGTCTTGCTCTGTCGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.4454623743539381					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199348	54199398	53286788	53286838	20429	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-15				AAAAAAAAAAAAAAAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199482	54199532	53286922	53286972	20430	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-2				CCAGGGCAAACCCACGGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23138376961235591					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199521	54199571	53286961	53287011	20431	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-3				AGGCCTGTCCCGCTCTGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24587240061770221					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199387	54199437	53286827	53286877	20432	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-4				GTGGCTGCGTTGCTCTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1052010431039118					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199493	54199543	53286933	53286983	20433	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-5				TGGCCCTTGTGCCTGTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22720490070321581					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199541	54199591	53286981	53287031	20434	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-6				ACTTCTTCAGTTACCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.093525767854667083					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199409	54199459	53286849	53286899	20435	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-7				TCCCTCTGCTGGGTCATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.93623684591839618					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199420	54199470	53286860	53286910	20436	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-8				TACTCCCCGGCTCCCTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44908950291609018					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158870	chr8	54199433	54199483	53286873	53286923	20437	hg38	N/A	N/A	N/A	Enhatls169714	enhancer	SOX17e+14-9				AGGGAGAGGGATGTACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35674459440092421					OPRK1	chr8	53225723	53251637	5064				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2661
enhrx-158868	chr8	54158220	54158270	53245660	53245710	20438	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-1				TTTGTGTGGCCATAACTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.089480645084939761					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54157950	54158000	53245390	53245440	20439	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-10				TGTCTGCAGGGCTTCCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55200119315711982					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158060	54158110	53245500	53245550	20440	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-11				TGGCAGCCTCAGCAAACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21667776830133351					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158034	54158084	53245474	53245524	20441	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-12				CAAAGCACCGCAGACTGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.020786957754914948					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158241	54158291	53245681	53245731	20442	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-13				AATGGATGAAACCATTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73765252064716813					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158182	54158232	53245622	53245672	20443	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-14				AGAGAGAGATAATTAGATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2979327401223428					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54157963	54158013	53245403	53245453	20444	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-15				CCTGCAGACACCTTGATCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2921624434532013					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158095	54158145	53245535	53245585	20445	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-2				GATGATCTCCCTGACACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073350730616117					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158002	54158052	53245442	53245492	20446	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-3				CTGTGAGACAATCAACAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29188342342248669					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158115	54158165	53245555	53245605	20447	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-4				ATCACACTGAGCCATTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21853205543079149					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54157935	54157985	53245375	53245425	20448	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-5				GAGAGAGGCCTCGGGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054502859057386513					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158143	54158193	53245583	53245633	20449	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-6				GTCCAGCTGAGTCTGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26347547124212067					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158079	54158129	53245519	53245569	20450	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-7				AGGGAGGCTCTAGAAACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16285315886776941					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158126	54158176	53245566	53245616	20451	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-8				CTGGACTCCTTCCTTCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11877287491687161					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158868	chr8	54158156	54158206	53245596	53245646	20452	hg38	N/A	N/A	N/A	Enhatls169712	enhancer	SOX17e+15-9				TGCAGAAAGGAATGGATAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.194882166526975					OPRK1	chr8	53225723	53251637	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2659
enhrx-158865	chr8	54013482	54013532	53100922	53100972	20453	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-1				GACATACCCTCCACGCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.279529566733088					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013395	54013445	53100835	53100885	20454	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-10				TTTCAAAAGCCACATCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60140168700582941					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013559	54013609	53100999	53101049	20455	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-11				GCTTGGAGTTTTTGACACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37861513178826772					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013599	54013649	53101039	53101089	20456	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-12				TCCAGAGCAGGGACAAATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.19497924766379					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013588	54013638	53101028	53101078	20457	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-13				TTGTGCCTGTGTCCAGAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.007073267518121997					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013617	54013667	53101057	53101107	20458	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-14				CTAATTGCTGCCATCACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46274825055714852					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013576	54013626	53101016	53101066	20459	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-15				CACAGGCACAAAGGAAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.091523865732553181					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013428	54013478	53100868	53100918	20460	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-2				TAACCAGCAACCAGGGTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.067643238416125614					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013677	54013727	53101117	53101167	20461	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-3				TCCCCTATAGCATGAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052051111463423047					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013657	54013707	53101097	53101147	20462	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-4				GGACTGGTTGGAATCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.212685634101887					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013639	54013689	53101079	53101129	20463	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-5				GTAGTAGTGCAGATCTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23809550265939369					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013499	54013549	53100939	53100989	20464	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-6				ATGTGGATTTCCCCAGCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6059290464939662					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013511	54013561	53100951	53101001	20465	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-7				AATCACTGCTTGCCTCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27921030010112829					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013523	54013573	53100963	53101013	20466	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-8				AAGCAGTGATTGTCTCAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1522148946638979					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	54013456	54013506	53100896	53100946	20467	hg38	N/A	N/A	N/A	Enhatls169709	enhancer	SOX17e+16-9				ACAGAGCTCTGACAGCATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.75649992003317468					OPRK1	chr8	53225723	53251637	80759				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931588	53931638	53019028	53019078	20468	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-1				CTACTGTGCCCCTTGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033931920916356					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931519	53931569	53018959	53019009	20469	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-10				AGAGTCCCAACCCCCAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.93845992776138					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931493	53931543	53018933	53018983	20470	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-11				CTTGCAAACCCACACCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22504212720396419					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931725	53931775	53019165	53019215	20471	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-12				GCTGCTGCCCTTCCCCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2246803216673809					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931530	53931580	53018970	53019020	20472	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-13				TCTGCAGGGCTCCAGGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.070994900486769125					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931711	53931761	53019151	53019201	20473	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-14				AACACATTAAGCTCCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13893935088856721					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931965	53932015	53019405	53019455	20474	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-15				TGCTCAGGCCTAGGGAGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.341143752453571					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931372	53931422	53018812	53018862	20475	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-16				GGGTGCTCCCTTGCCCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.049829285676349748					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931507	53931557	53018947	53018997	20476	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-17				GTTGGGACTCTGGGCCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59951269014294928					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931766	53931816	53019206	53019256	20477	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-18				GCTTCAGCAGGGGAAAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71766818059139847					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931621	53931671	53019061	53019111	20478	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-19				GGCAGCTTCAGCTGTGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1925682922235106					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931388	53931438	53018828	53018878	20479	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-2				AGCACCCGCTTCCCGGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14371770489416691					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931946	53931996	53019386	53019436	20480	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-20				AGAAGCTCAGGGACAGAACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24521519413312329					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931743	53931793	53019183	53019233	20481	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-21				GCAGCTATCTCTATTGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052491086394840361					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931649	53931699	53019089	53019139	20482	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-22				CCTAAGCTGTTTGAGCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24745196983624321					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931432	53931482	53018872	53018922	20483	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-23				AAAACACAGTTTCCCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0678153883505484					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931404	53931454	53018844	53018894	20484	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-24				TGTTTACTCACTGCCTCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016050220375427068					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931857	53931907	53019297	53019347	20485	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-25				TGCGGCCAGAGCACCTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2470078359169193					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931880	53931930	53019320	53019370	20486	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-26				AGGAAGGGTGTGTCAGGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.049332890100312221					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931824	53931874	53019264	53019314	20487	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-27				GCTGGTGTGTTGGGCTGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25810941413720512					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53932042	53932092	53019482	53019532	20488	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-28				TGGGATTCCTCAGAACTACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01043798166801309					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931842	53931892	53019282	53019332	20489	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-29				TGGCCGCAGTCTGCCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.074158360872384421					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931474	53931524	53018914	53018964	20490	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-3				CAAGTGGAATCTTTGATCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44434190005520652					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931673	53931723	53019113	53019163	20491	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-30				GGAGGGGCAGCAGCCAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56658297103705657					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931813	53931863	53019253	53019303	20492	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-31				GGGCTGTGGGGGACACCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.72173466801802633					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931931	53931981	53019371	53019421	20493	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-32				GAGCTTCTGGCTGGAGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17780714624971641					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931782	53931832	53019222	53019272	20494	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-33				CTGAAGCCAGGGAGGCTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5947848133736311					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53932024	53932074	53019464	53019514	20495	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-34				GCAGACTTAGCCTTTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10067564580617749					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931457	53931507	53018897	53018947	20496	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-35				CCACAGAACTGTGCAACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57917891405097932					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931357	53931407	53018797	53018847	20497	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-36				CGGCCCACCTGAGAGCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25807494903605838					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931563	53931613	53019003	53019053	20498	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-37				TTAGGCAGATTCCAGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.037738374993289532					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931919	53931969	53019359	53019409	20499	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-38				GGAGTTGTTGGAGTTCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23656693014648311					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931798	53931848	53019238	53019288	20500	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-4				TGGACGGCTTGGTCTCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2118649866455227					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931420	53931470	53018860	53018910	20501	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-5				GTAAACATGCTACCTAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51543099414600857					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931686	53931736	53019126	53019176	20502	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-6				GTTGCTATCAGTCCCAGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26348476071943688					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931545	53931595	53018985	53019035	20503	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-7				AGAGGCTACTGAGAATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.65106497824634457					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931977	53932027	53019417	53019467	20504	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-8				AGGCCTGAGCACTTAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6540653973912551					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158865	chr8	53931895	53931945	53019335	53019385	20505	hg38	N/A	enh91861	N/A	Enhatls169709	enhancer	SOX17e+17-9				AAGCCCCACCCAGTGAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18393103757515589					NPBWR1	chr8	52939181	52943734	73372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2656
enhrx-158846	chr8	53502426	53502476	52589866	52589916	20506	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-01				TTTACCCCCCGAAAGCAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1599241097407032					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502484	53502534	52589924	52589974	20507	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-02				TGCACATTGTCATGCAACGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14532756629871221					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502218	53502268	52589658	52589708	20508	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-03				CACCCCTCAAGTGTTAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12585769482796111					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502302	53502352	52589742	52589792	20509	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-04				TGATACGCATATGAACAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.051102666495731079					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502325	53502375	52589765	52589815	20510	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-05				TTGTGAGCTCAGAAATTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20648657433274051					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502472	53502522	52589912	52589962	20511	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-06				GACAATGTGCAGCAGCATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.047397841452001363					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502508	53502558	52589948	52589998	20512	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-07				CACCTTCAGTGTGAAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.071715622496317188					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502414	53502464	52589854	52589904	20513	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-08				AAGCAATTGGGAAAAGGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.636600509738097					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502242	53502292	52589682	52589732	20514	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-09				GATGTGTGGTGTTTATATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32750449075858412					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502344	53502394	52589784	52589834	20515	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-10				ATGGTTCATACACAGAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31088526828737972					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502377	53502427	52589817	52589867	20516	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-11				AACCCCAGAGAGAAGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25951670970959212					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502402	53502452	52589842	52589892	20517	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-12				AAAGGGACTGGAGTGGATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9209041977039375					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158846	chr8	53502530	53502580	52589970	52590020	20518	hg38	N/A	N/A	N/A	Enhatls169690	enhancer	SOX17e+18-13				GAGAAAAGAGATAAATTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1987780591185611					ALKAL1	chr8	52534036	52565430	5261				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2637
enhrx-158841	chr8	53380029	53380079	52467469	52467519	20519	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-01				TCTCGTGAGATCGATCTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39934608753585832					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380079	53380129	52467519	52467569	20520	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-02				GCGGTTCTTTTCTAACAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38936377811351031					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380097	53380147	52467537	52467587	20521	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-03				CCTGGCATTATTTTGCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10627133642814331					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379820	53379870	52467260	52467310	20522	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-04				CTGCATGAAGGGCCGCCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48560780523995911					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379913	53379963	52467353	52467403	20523	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-05				TCCTGTTCAGGGGCGACCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40747579509646548					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379836	53379886	52467276	52467326	20524	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-06				CACGGGGTGTGTCTTCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22727311158466451					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379947	53379997	52467387	52467437	20525	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-07				CTGCCTGCCGTTCCAGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.031020889271362231					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380017	53380067	52467457	52467507	20526	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-08				GATCTGTCAGGTTAGTCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13911909839598319					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379901	53379951	52467341	52467391	20527	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-09				GCGACCGCAGGGGACTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1034169142600579					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379987	53380037	52467427	52467477	20528	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-10				AGGCTTGTCATGAGTGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.155695690575238					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379959	53380009	52467399	52467449	20529	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-11				ATTACAGGACCTCCTTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060320989269542637					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379781	53379831	52467221	52467271	20530	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-12				GATTGCCAAGCAGTGTTGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034235711341587358					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379974	53380024	52467414	52467464	20531	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-13				GTGAAGGAGGCGCTGATTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.016953248658974369					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379808	53379858	52467248	52467298	20532	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-14				CAAATACTCATGCTGCATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1670754655193174					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379721	53379771	52467161	52467211	20533	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-15				TTAGGTAAAGTTCACATCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21631157105790319					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379853	53379903	52467293	52467343	20534	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-16				GCGGGAGTGCCACCTTCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4708792912876709					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379751	53379801	52467191	52467241	20535	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-17				GACAATGCAGTTTTACAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14619448541231531					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379925	53379975	52467365	52467415	20536	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-18				GTGGTCAGTGCTTCCTGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46120334511774669					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379888	53379938	52467328	52467378	20537	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-19				ACTTGCCTGGCAGAGCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1890404470287993					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380121	53380171	52467561	52467611	20538	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-20				TCTCACTACAGCAGCAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40025134677045132					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380064	53380114	52467504	52467554	20539	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-21				AGAACCGCTGGGAGAGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.699632652678754					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53380053	53380103	52467493	52467543	20540	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-22				GAGAGGAGGAGGTAAACGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26415758878991491					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158841	chr8	53379877	53379927	52467317	52467367	20541	hg38	N/A	N/A	N/A	Enhatls169685	enhancer	SOX17e+19-23				AGAGCAGGGAGGGAGCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0666186167163278					ALKAL1	chr8	52534036	52565430	17492				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2632
enhrx-158914	chr8	55356227	55356277	54443667	54443717	20542	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-1				AGATCTCCCGTTGTTTGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5390184150752679					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356652	55356702	54444092	54444142	20543	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-10				GCTTCAATAAAATCTCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53007995059690372					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356556	55356606	54443996	54444046	20544	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-11				CATTATCTCACAGAGCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7510484179388961					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356406	55356456	54443846	54443896	20545	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-12				TCCACAATCTCCCCTGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.932360030064731					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356610	55356660	54444050	54444100	20546	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-13				AGGAGGAATGTCCCCTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.972056421784832					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356528	55356578	54443968	54444018	20547	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-14				TATAACCATCACCCTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.622068537421097					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356369	55356419	54443809	54443859	20548	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-15				ACAGCAGATATGCAGTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.101440126000008					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356701	55356751	54444141	54444191	20549	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-16				GACGTGAAAATGTGTGGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4807191895204519					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356343	55356393	54443783	54443833	20550	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-17				CTCTTTGAAGGTGTTTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.970255629509195					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356273	55356323	54443713	54443763	20551	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-18				ATCCCTGCCAAGCCACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.880024439909298					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356318	55356368	54443758	54443808	20552	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-19				ATGAGACCACAGCTATCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.934316089895654					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356478	55356528	54443918	54443968	20553	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-2				AGGTATCTTAATCCAGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.42459627941859					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356585	55356635	54444025	54444075	20554	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-20				TAATGAAATACATGTCCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7072251374825812					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356182	55356232	54443622	54443672	20555	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-21				TGACACAAGTGAGGGGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	12.13237744058725					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356677	55356727	54444117	54444167	20556	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-22				AGAGTGTTTTAAAGAACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.06052352532159					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356498	55356548	54443938	54443988	20557	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-23				CTAAATAATTTTGACTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35272581518399032					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356540	55356590	54443980	54444030	20558	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-24				AAGCAGGAACTTCCAAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.6161355505568991					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356293	55356343	54443733	54443783	20559	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-25				GATTCCTTCTTCCCAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4596858807632529					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356355	55356405	54443795	54443845	20560	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-26				ATCTGCTGTGAGCTCTTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.646822267441354					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356305	55356355	54443745	54443795	20561	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-27				TATCACCTGGAGCCAGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71469990332032629					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356417	55356467	54443857	54443907	20562	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-28				GGAGATTGTGGAGGGGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1942979342210869					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356627	55356677	54444067	54444117	20563	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-3				CATTATGTCACTTTAAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3242298029966779					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356261	55356311	54443701	54443751	20564	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-4				TTTCTGAGTCAACCTGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.390852328537348					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356394	55356444	54443834	54443884	20565	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-5				GATTGGCTTTCTCCAAACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.3187467253919261					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356597	55356647	54444037	54444087	20566	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-6				TGTCCATAGGGGTCCCCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.1037364651332631					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356170	55356220	54443610	54443660	20567	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-7				CACTTGTGTCACTCTTTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4359504554591609					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356466	55356516	54443906	54443956	20568	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-8				AAACATAATTAACCGGCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61708874851023965					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55356735	55356785	54444175	54444225	20569	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+2-9				GTCAAATGCTTGCCCAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.426397804059532					SOX17	chr8	54457934	54460892	13650				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55295065	55295115	54382505	54382555	20570	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-1				GCACCGATCATGAGTCACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022138834366509579					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294950	55295000	54382390	54382440	20571	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-10				CAAGCCTGGCGGCCGAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6735671971725248					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294742	55294792	54382182	54382232	20572	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-11				AGGTCCTGCCGTCTGAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2421823947936296					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294466	55294516	54381906	54381956	20573	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-12				CGCTGACCGCAGAGGCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0591433551099749					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294811	55294861	54382251	54382301	20574	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-13				CAGCAGTGGGAGCGGTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84201939096744316					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294576	55294626	54382016	54382066	20575	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-14				ATACAGCCGCTGCATCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.552254156632874					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294826	55294876	54382266	54382316	20576	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-15				TCTCTGGGCTGGGTATACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.04516919782473					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294897	55294947	54382337	54382387	20577	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-16				ACAGTTTGTGCTGCAATGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52806721940087					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294961	55295011	54382401	54382451	20578	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-17				CATTTATACAGCAAGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18533950495873139					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294800	55294850	54382240	54382290	20579	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-18				CTCCCACTGCTGAGAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4287220820102211					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294773	55294823	54382213	54382263	20580	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-19				GCGTCTGGCTCCTTGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36067333016089331					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294848	55294898	54382288	54382338	20581	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-2				GTATTATCTCAAGCCAACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0276646727733041					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294672	55294722	54382112	54382162	20582	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-20				CTCACCTTCCAGAGGAAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2335838994490716					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294649	55294699	54382089	54382139	20583	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-21				AGTCATGAAGTCTGGCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1151314491982104					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294532	55294582	54381972	54382022	20584	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-22				ATTTAAAGTCCCAGCAACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56814503714794951					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294623	55294673	54382063	54382113	20585	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-23				GGGGTGGGGGAAGCTCATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23219395990012059					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55295034	55295084	54382474	54382524	20586	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-24				CATTGTATTTTTATCCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1600523144749031					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294938	55294988	54382378	54382428	20587	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-25				CGGACACACTCACCCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.87103005479370255					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294720	55294770	54382160	54382210	20588	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-26				GGTGTGTGTCCCCTCCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.534731224676976					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294788	55294838	54382228	54382278	20589	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-27				AGAGCCCGGGGCCTGGCGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.720294603927861					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294762	55294812	54382202	54382252	20590	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-28				CTTGGCTGCGGGCCAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21373419017538189					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294590	55294640	54382030	54382080	20591	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-29				TCCCAGTGGAAAACAAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087144822556891988					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294519	55294569	54381959	54382009	20592	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-3				GCAACGCAGGAGCTGATGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70630221801885251					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294865	55294915	54382305	54382355	20593	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-4				ATTGCGAGTTTCTGCAGCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16110048494781229					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294601	55294651	54382041	54382091	20594	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-5				AACAAAAGCCGGGCTAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.056239242376516611					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294701	55294751	54382141	54382191	20595	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-6				GCGGTCCACACACACAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64390594005119806					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55295048	55295098	54382488	54382538	20596	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-7				CGGTGCAGGTCCTTCCAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22208547205704909					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55295000	55295050	54382440	54382490	20597	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-8				TGCAGCGTCTGCAATTCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46956014711195559					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55294918	55294968	54382358	54382408	20598	hg38	N/A	enh46573	N/A	Enhatls169759	enhancer	SOX17e+3-9				GTCCGATTTCCAACTGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15688347069428879					SOX17	chr8	54457934	54460892	72620				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214590	55214640	54302030	54302080	20599	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-1				GCGCTCTCCAGAAGGTATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.99091930897057					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214902	55214952	54302342	54302392	20600	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-10				AAAGGGAGGTGCTTTCTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.451035943303407					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214820	55214870	54302260	54302310	20601	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-11				ACAAGAGGGAGAATTTATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.0871387256248992					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214976	55215026	54302416	54302466	20602	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-12				TTCAAAGTAAAAGCCCCACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.9264141062516358					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214866	55214916	54302306	54302356	20603	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-13				AGACTATTACCCTATTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.83150721154528					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214731	55214781	54302171	54302221	20604	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-14				TTTGCAGCTCTGCTAATTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8061149428660812					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214713	55214763	54302153	54302203	20605	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-15				GCAAACTGCTATTGTTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.052589008595842					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214805	55214855	54302245	54302295	20606	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-16				GAAACCCTGGCTGAAACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6206483778761287					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214760	55214810	54302200	54302250	20607	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-17				TAATTCTAACAGTAACAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.32783120681036					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214690	55214740	54302130	54302180	20608	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-18				TCTCCACATATCTTAACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3165341304862546					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214773	55214823	54302213	54302263	20609	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-19				GTTAGAATTACTGAGCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30347517586319422					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214550	55214600	54301990	54302040	20610	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-2				GCAATCTTTAACACGAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.6686045077613763					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214524	55214574	54301964	54302014	20611	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-20				GTTTAGTTTTTGCTCTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15521359892233269					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214656	55214706	54302096	54302146	20612	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-3				GGCCCAAATAGATTCTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.3244891089432747					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214677	55214727	54302117	54302167	20613	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-4				TAACTTCAGGATCCCTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.6767274267890127					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214631	55214681	54302071	54302121	20614	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-5				ACCTAAGGCTGAGACACTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.03537205912783					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214792	55214842	54302232	54302282	20615	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-6				AAGGTATTGTATTGAAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.8100697729091761					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214616	55214666	54302056	54302106	20616	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-7				TGGGAAGGCAGAATAACCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.1261276476918631					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214601	55214651	54302041	54302091	20617	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-8				TCTGGAGAGCGCTCATGGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.498784008773792					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55214888	55214938	54302328	54302378	20618	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+4-9				TCACAAACTGAATTAAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6330234206574206					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213188	55213238	54300628	54300678	20619	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-1				GACTCACCCGGCTCTAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.0192844935165484					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213402	55213452	54300842	54300892	20620	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-10				ATAATTGTGGAGTGAACCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.21529536032049					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213254	55213304	54300694	54300744	20621	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-11				AATTATAACATCACATGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19417565041000689					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213418	55213468	54300858	54300908	20622	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-12				GTGTCTGTTTTAATTACCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.013003680556788581					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213154	55213204	54300594	54300644	20623	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-13				CTAAGGAAGTGACTTCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.4128759824020278					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213298	55213348	54300738	54300788	20624	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-14				AAAGTTTATAAACTTTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4982185007821416					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213494	55213544	54300934	54300984	20625	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-15				GGAAACAAAGATAGCAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.317035882613065					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213176	55213226	54300616	54300666	20626	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-16				GAAGTCATCCTGGACTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9511512493398593					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213473	55213523	54300913	54300963	20627	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-17				GGTGAAGTCAGGAGCAGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.1961642512926254					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213137	55213187	54300577	54300627	20628	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-18				AATACTTTCTTCTCATTCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.76353290880926561					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213435	55213485	54300875	54300925	20629	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-19				AGACACTTGGAAAGAAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6565359252483649					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213213	55213263	54300653	54300703	20630	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-2				CCTGACGAGCATCATGCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9154936115704					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213278	55213328	54300718	54300768	20631	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-20				AGGAACACAAAGAAGAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4381759754491634					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213506	55213556	54300946	54300996	20632	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-21				AGCAGGGGAGGGTGGCCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.0267063894063568					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213377	55213427	54300817	54300867	20633	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-3				TTCCCGATACAGGAGGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7360379049251877					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213330	55213380	54300770	54300820	20634	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-4				GACTTTGTCGAAGTTGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.15600426776738					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213354	55213404	54300794	54300844	20635	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-5				TTTATCAGCAGCACCTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6043593408261634					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213462	55213512	54300902	54300952	20636	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-6				CATAGATTAAAGGTGAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.3683881696593163					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213389	55213439	54300829	54300879	20637	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-7				GAGGTGTCAGGAAATAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9997932726800416					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213521	55213571	54300961	54301011	20638	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-8				AACAAATGACCCTTACCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.63322029205687					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55213241	55213291	54300681	54300731	20639	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+5-9				CATGACAAGGGCTGTGATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.0076485249981344					SOX17	chr8	54457934	54460892	133370				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185818	55185868	54273258	54273308	20640	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-1				AGCCCACTCATTAGACCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.1967603893439946					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185990	55186040	54273430	54273480	20641	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-10				GGGTTGATAGGAGCTAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6450835564133279					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55186070	55186120	54273510	54273560	20642	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-11				GTGATTATTTCAGTTGTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1061193180881591					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185801	55185851	54273241	54273291	20643	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-12				GAATACACTGAAAACATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.566001094055542					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185920	55185970	54273360	54273410	20644	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-13				AGCAAGATCTTTTTTTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21116191100499021					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185714	55185764	54273154	54273204	20645	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-14				CTGAGTGAGTGCTTGTAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9343521206126328					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185669	55185719	54273109	54273159	20646	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-15				GAACATACAGTTTAGTAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.372830612796367					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55186043	55186093	54273483	54273533	20647	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-16				TGAAACTCCTCAGCTCTGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2763262462071061					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55186111	55186161	54273551	54273601	20648	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-17				AAACATTTTCTAACACATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.14951630518744					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185978	55186028	54273418	54273468	20649	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-18				AGTGTTGGGGGTGGGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.524047003182369					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185763	55185813	54273203	54273253	20650	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-19				TTGAATCAGTGAAAAATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73633571717140878					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185834	55185884	54273274	54273324	20651	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-2				GTGGGCTTAAATCCTGTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.2272452871876278					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185592	55185642	54273032	54273082	20652	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-20				GAAAAAACATCTATAAAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515852					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185642	55185692	54273082	54273132	20653	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-21				TCTCTCTTTTTTTTTTTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4703264404695631					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185946	55185996	54273386	54273436	20654	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-3				ACTAGAACTGTCCTCATCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8621138078092718					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185846	55185896	54273286	54273336	20655	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-4				TGCAATCCAAATCCCTACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.061153767761414					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185935	55185985	54273375	54273425	20656	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-5				ATCTTGCTTCCCCCATGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9172353272202551					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55186016	55186066	54273456	54273506	20657	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-6				GGTCCATTCACAAATTAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.046722113621859					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185964	55186014	54273404	54273454	20658	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-7				CTAGTTTGGATGGGAGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.557145051710469					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185692	55185742	54273132	54273182	20659	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-8				GTATGCTTTCTATACCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.712906612136577					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55185894	55185944	54273334	54273384	20660	hg38	N/A	N/A	N/A	Enhatls169759	enhancer	SOX17e+6-9				CTCTAAGAAGCCAGTGCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4610802709947051					MRPL15	chr8	54135240	54148514	122747				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181165	55181215	54268605	54268655	20661	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-1				GCAGGTGTAGAATGCCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7056598972652743					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181221	55181271	54268661	54268711	20662	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-10				AACCTGGTTCCCTCTATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49017060340112939					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180974	55181024	54268414	54268464	20663	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-11				GGTCTCAGACCACACATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7547506987139858					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181208	55181258	54268648	54268698	20664	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-12				GAACCAGGTTAGGGACATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7686670265402507					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180771	55180821	54268211	54268261	20665	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-13				GGGAGCACCTTCCCAGTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.51737010404131					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180917	55180967	54268357	54268407	20666	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-14				CATGAGCTAGTGATGAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.4138448892850857					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180935	55180985	54268375	54268425	20667	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-15				GCAGGATAAGAGGCCCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.6729544899520929					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181237	55181287	54268677	54268727	20668	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-16				TTTTGGGTTGAGGAAACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.5142616376892137					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180691	55180741	54268131	54268181	20669	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-17				CTACATGAAAGGAGGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.5167545534935218					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181255	55181305	54268695	54268745	20670	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-18				TGGGTGACCCAAAATAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.09501413922819					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180882	55180932	54268322	54268372	20671	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-19				AAGTGCTTTGTCTTTGGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.3697299173942739					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180994	55181044	54268434	54268484	20672	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-2				TGGAGGCCTTGTTTTGTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.9999876523885174					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180760	55180810	54268200	54268250	20673	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-20				CCAAAAATGTCCCCAACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.5463728661509251					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180803	55180853	54268243	54268293	20674	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-21				GCCAGAAATTTGCATCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.6096387752558781					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180680	55180730	54268120	54268170	20675	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-22				TTGATAAGATGCTACATGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9664010254667144					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181056	55181106	54268496	54268546	20676	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-23				GACTTCTTAAATCCTGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.4452873360956167					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181299	55181349	54268739	54268789	20677	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-24				ACTTCTGTTCAAAGCCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.0388419308013646					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180869	55180919	54268309	54268359	20678	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-25				TTGGCAGTGGAGGGTCCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6573822384166554					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181105	55181155	54268545	54268595	20679	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-26				GAATCTGGGCAAAGTGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.269061090927174					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181126	55181176	54268566	54268616	20680	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-27				GGCTGGCTAGAGAGGACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.706790257907997					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181191	55181241	54268631	54268681	20681	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-28				TCTTGGTTGAGGAAACAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6989941064961274					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181274	55181324	54268714	54268764	20682	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-29				TAAATGATTAATATTAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0231304537798378					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181036	55181086	54268476	54268526	20683	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-3				GTCTGCCACCCTTTACTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.6357663547498467					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181179	55181229	54268619	54268669	20684	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-30				AAACAAACAGGTTTCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7735048030201126					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180748	55180798	54268188	54268238	20685	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-31				GACATTTTTGGAGTTGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.5867404722997547					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181090	55181140	54268530	54268580	20686	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-4				GAGGGGATTAGGCTTGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.5889936292620508					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180855	55180905	54268295	54268345	20687	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-5				TCCTTCCGGAGACTCAAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.8113026646268713					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181071	55181121	54268511	54268561	20688	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-6				GCTAATGGAGTTTGACAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.9347567622271917					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55181153	55181203	54268593	54268643	20689	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-7				TCTACACCTGCTTGGAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.7463403780790276					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180792	55180842	54268232	54268282	20690	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-8				GCATCTGAGTGGGCCCTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	8.45847145864354					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55180949	55180999	54268389	54268439	20691	hg38	N/A	enh41004	N/A	Enhatls169759	enhancer	SOX17e+7-9				GCCCCATATCTCATCCTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	7.7619066061654882					MRPL15	chr8	54135240	54148514	118405				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172687	55172737	54260127	54260177	20692	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-1				CTTGTGGTATGATACTTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8790121274074059					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172861	55172911	54260301	54260351	20693	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-10				CTAGCTTCTATGCCTCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16818323963802151					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172386	55172436	54259826	54259876	20694	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-11				AATTCAAGAGTTGCTAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3402549090232414					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172459	55172509	54259899	54259949	20695	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-12				GAGAGATGATTTCTAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5631645172392929					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172586	55172636	54260026	54260076	20696	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-13				TTACAGCTGGGGCTGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.96966182659596					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172499	55172549	54259939	54259989	20697	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-14				GTGAAGATAGGAAAAGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.5888161612999379					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172547	55172597	54259987	54260037	20698	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-15				ACAGCAGGATCAGAGAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.2380376923843341					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172792	55172842	54260232	54260282	20699	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-16				GTTTTAATTTCTTGGAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24270320460572631					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172562	55172612	54260002	54260052	20700	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-17				ACAGTGGAGAAGCAAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.608546639885934					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172445	55172495	54259885	54259935	20701	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-18				AGCTCTGGGGAGAAATAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.0255951525654181					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172761	55172811	54260201	54260251	20702	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-19				TTAGAAATTTAACATATAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-8.618995934024527					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172873	55172923	54260313	54260363	20703	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-2				ACTTGAAGTGCTCCCAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.7412849369980812					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172831	55172881	54260271	54260321	20704	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-20				TATAAATTCTTTTACTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.0140001778293581					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172671	55172721	54260111	54260161	20705	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-3				ACTTGGCTTGGTAAATCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.3980390372669111					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172659	55172709	54260099	54260149	20706	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-4				GCATTGAGCAACACTTGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.3873347057927088					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172729	55172779	54260169	54260219	20707	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-5				GTTAGACTTTGCTGGTATTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8424965130364439					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172614	55172664	54260054	54260104	20708	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-6				AATGTAATGCTAACAGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.845632261043705					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172511	55172561	54259951	54260001	20709	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-7				TGCACAATAGCTGTGAAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.9562016711324581					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172573	55172623	54260013	54260063	20710	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-8				CTTCTCCACTGTGTTACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.9297719447741031					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55172714	55172764	54260154	54260204	20711	hg38	N/A	enh73256	N/A	Enhatls169759	enhancer	SOX17e+8-9				TATTCTGGCAGCTACAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.8223816070077139					MRPL15	chr8	54135240	54148514	108611				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140856	55140906	54228296	54228346	20712	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-1				TGCCACAATGGGACATTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4324734627648952					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140774	55140824	54228214	54228264	20713	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-10				CATCTTCAGGGGGACAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.4157895753048091					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140957	55141007	54228397	54228447	20714	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-11				CAAATTCAAAGGGAGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.664092989615731					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140968	55141018	54228408	54228458	20715	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-12				TGCAGCAGTTGCAAATTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034090135552758812					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140790	55140840	54228230	54228280	20716	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-13				GACCTGGAGACTGAAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78669524869094831					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140944	55140994	54228384	54228434	20717	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-14				AGCTCAGTGGCCCAAGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.298792742732517					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55141019	55141069	54228459	54228509	20718	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-15				GGGAGAACAGGAAGAGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.747312160329985					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140996	55141046	54228436	54228486	20719	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-16				TGTGTGTGTTACAGATTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19301954672567251					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140748	55140798	54228188	54228238	20720	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-17				GTGGCAGCCCAGGTGGTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.4910324290673649					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140808	55140858	54228248	54228298	20721	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-18				GAAGGGAAAATGTGGAAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4801447640268614					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55141031	55141081	54228471	54228521	20722	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-19				AGTCATGGGGGAGGGAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.8866107170969149					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140844	55140894	54228284	54228334	20723	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-2				CGCCCTTGCATCTGCCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32489966164768441					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140889	55140939	54228329	54228379	20724	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-3				ATGAAACAATAGACTTCGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.732808936414079					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140909	55140959	54228349	54228399	20725	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-4				AGGACATAATACCCATTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.920322633225044					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55141046	55141096	54228486	54228536	20726	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-5				GTAGAGCAGAAGTTAAGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47419057458784553					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140762	55140812	54228202	54228252	20727	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-6				GGTGAGAGGAACCATCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.281398908116381					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140933	55140983	54228373	54228423	20728	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-7				CAGCTTTACATCCTAGCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42371506040313389					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55140920	55140970	54228360	54228410	20729	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-8				TGTAAAGCTGACCTCTGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.8971855827092461					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-158914	chr8	55141064	55141114	54228504	54228554	20730	hg38	N/A	enh109170	N/A	Enhatls169759	enhancer	SOX17e+9-9				TCTACTCTTCCAGTAAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4709767948406809					MRPL15	chr8	54135240	54148514	75972				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	2705
enhrx-121199	chr3	181433585	181433635	181715797	181715847	20731	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-1				GCGGGTACTTTACTCAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50130785632974051					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433973	181434023	181716185	181716235	20732	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-10				TCGTATGTGTGAGCAAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40970158205925628					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433810	181433860	181716022	181716072	20733	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-11				GGATAACATTGTACTGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.66797268813884758					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433537	181433587	181715749	181715799	20734	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-12				GTGTCAACTTGCTACAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.53436472121863343					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433679	181433729	181715891	181715941	20735	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-13				GTGTTGCTAATGTTAGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26956453743562581					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433845	181433895	181716057	181716107	20736	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-14				CCAGTTCCCAATTCTAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2344940947419222					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433572	181433622	181715784	181715834	20737	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-15				TCAAGGGTGGAAGACGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.194511784945359					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433690	181433740	181715902	181715952	20738	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-16				GTTAGTTCTGGGCTGAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25228807543550391					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433603	181433653	181715815	181715865	20739	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-17				GCTAACTTAGTGGCTGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027275924344709289					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433459	181433509	181715671	181715721	20740	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-18				GTTCCTGGTCCCCGTGGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1114744064617922					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433448	181433498	181715660	181715710	20741	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-19				CGCTCGTCTTCCCCCACCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.031235980347516					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433615	181433665	181715827	181715877	20742	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-2				ACTAAGTTAGCTCATCCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29732321193754713					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433898	181433948	181716110	181716160	20743	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-20				TAAAAGAATTTCCCCTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1139687200354461					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433519	181433569	181715731	181715781	20744	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-21				GACACAAGCTCTTGAAATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0941132427439588					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433630	181433680	181715842	181715892	20745	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-22				ATGAGAAGATGCAAACCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.9515254404539556					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433753	181433803	181715965	181716015	20746	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-23				GCTTTGTTTTAGATATGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27794379484835308					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433553	181433603	181715765	181715815	20747	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-24				ACTTTGGAGAAGTTGGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.087597053634929811					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433799	181433849	181716011	181716061	20748	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-25				ACAATGTTATCCTAAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42481469370038061					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181434032	181434082	181716244	181716294	20749	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-26				AATATCCTCCCCACTCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.275703929075733					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181434109	181434159	181716321	181716371	20750	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-27				TATATTAGAAATATGTATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75425900276254976					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181434109	181434159	181716321	181716371	20751	hg38	N/A	enh36198	N/A	Enhatls129688	enhancer	SOX2e-1-27				TATATTAGAAATATGTATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.75425900276254976					SOX2	chr3	181711924	181714436	1907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433655	181433705	181715867	181715917	20752	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-28				ATGAGAAAGAAATACTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-10.051130809438551					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433935	181433985	181716147	181716197	20753	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-3				GCATATACGGATTATTCACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55745958677614194					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181434020	181434070	181716232	181716282	20754	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-4				ACTCCCCCAGGATGATCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3487408673870951					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433474	181433524	181715686	181715736	20755	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-5				AGTGCCCGATTGTTGGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36373263226857461					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433875	181433925	181716087	181716137	20756	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-6				GAGTCTCTGCATTAATTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29242398414623277					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433916	181433966	181716128	181716178	20757	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-7				ATGCATTACAATGGCTGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055996034551475213					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181433488	181433538	181715700	181715750	20758	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-8				TCGGGCACTTTTAAGAGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73738067975556087					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121199	chr3	181434046	181434096	181716258	181716308	20759	hg38	N/A	N/A	N/A	Enhatls129688	enhancer	SOX2e-1-9				GAGGATATTCCCGGAATTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50301806296400975					SOX2	chr3	181711924	181714436	857				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9328
enhrx-121206	chr3	181857831	181857881	182140043	182140093	20760	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-1				GTGTCGTCTTGTCTTTAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.034655361885793233					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858130	181858180	182140342	182140392	20761	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-10				TCAAATGAGGGAGCAAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.012851975033897071					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858020	181858070	182140232	182140282	20762	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-11				TTCTTCTAATTCAAACTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26512919265489732					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857847	181857897	182140059	182140109	20763	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-12				AGTCTGGCTTGAGCTGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71230499331146191					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857892	181857942	182140104	182140154	20764	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-13				TTCAATTTCACACACCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1218654718606877					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857756	181857806	182139968	182140018	20765	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-14				CCTTCATGTGCTGCCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23622433812988511					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857863	181857913	182140075	182140125	20766	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-15				AGGCTGCCCCAGAAGCCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24397484456657029					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858118	181858168	182140330	182140380	20767	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-16				TTTCATCAGGAGTCAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12101720842254871					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857911	181857961	182140123	182140173	20768	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-17				TGAAGACAAACATTTTTACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27124846959208221					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858068	181858118	182140280	182140330	20769	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-18				TTCATGGGCTGGGTGAACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37883884691615821					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857769	181857819	182139981	182140031	20770	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-19				AGTTGAGGGAGGGCCAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	10.41249967171966					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857877	181857927	182140089	182140139	20771	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-2				GGGCAGCCTTGATGTCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67006756903935194					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857795	181857845	182140007	182140057	20772	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-20				TTTGTGTATGTGTGTATGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18450494844939169					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857809	181857859	182140021	182140071	20773	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-21				ATACACAAACACACGCACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42270250634632728					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857977	181858027	182140189	182140239	20774	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-3				GCCTTTGTTCCTACCCATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.035296904606611751					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857951	181858001	182140163	182140213	20775	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-4				AAGTAAACTGTAGGCCCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.029454081171701271					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857966	181858016	182140178	182140228	20776	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-5				TACCCATCAAGGACACCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47184461286296148					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857999	181858049	182140211	182140261	20777	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-6				GGCTCTTTTTGCTTCACCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19689402594855071					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858057	181858107	182140269	182140319	20778	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-7				CCTGCTCCAAGTTCATGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.11441605385650409					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181857784	181857834	182139996	182140046	20779	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-8				GTGTATGAGCGGGAGAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.562909388918514					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181858105	181858155	182140317	182140367	20780	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-10-9				CTCCAAGTCTCCGTTTCATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17305592336185879					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860981	181861031	182143193	182143243	20781	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-1				TCCCCGTGCATTGAAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33754816191324061					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860756	181860806	182142968	182143018	20782	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-10				CTTCTGCTGCCAGTCACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10433446038037041					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860810	181860860	182143022	182143072	20783	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-11				AAGAATGATTTCATGCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47581422387851541					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861026	181861076	182143238	182143288	20784	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-12				TTTGAATGAAGGATGAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5388956209331498					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861015	181861065	182143227	182143277	20785	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-13				TAGTGAATGACTTTGAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.060073749002775741					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860713	181860763	182142925	182142975	20786	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-14				GTTAAAAATTACCATAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.332316697843554					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860951	181861001	182143163	182143213	20787	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-15				AACACATCTTGTTTTCAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31325462101402962					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861103	181861153	182143315	182143365	20788	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-16				GAAGAAGAAAAGAAAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.8970928301761063					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861076	181861126	182143288	182143338	20789	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-17				AAAAAAAGAAGAGAAGAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.0010369379492046					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861120	181861170	182143332	182143382	20790	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-18				TTCTTCTTTTTTTTTTTTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.071129535229114152					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860724	181860774	182142936	182142986	20791	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-2				CAGGTGTCTTGCCTGCCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69751259631755425					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860876	181860926	182143088	182143138	20792	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-3				AGGGGGGGATCTCAAAGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51441001664578778					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860743	181860793	182142955	182143005	20793	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-4				GCAGCAGAAGGTTCTTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38915548706987468					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860860	181860910	182143072	182143122	20794	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-5				ACAGTATGCAGAAATTAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16204015648553111					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181861039	181861089	182143251	182143301	20795	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-6				TGAATAGGGGACATAACAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44918117725952939					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860916	181860966	182143128	182143178	20796	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-7				GTTCTGCATATAAATAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2516480001838539					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860792	181860842	182143004	182143054	20797	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-8				AGAGATGCAAACAACTGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15689027534506109					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181860894	181860944	182143106	182143156	20798	hg38	N/A	enh71024	N/A	Enhatls129697	enhancer	SOX2e-11-9				ATTGGGATGAAAATTTCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42106837539025638					SOX2	chr3	181711924	181714436	425473				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898711	181898761	182180923	182180973	20799	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-1				TCGCCCGTTATCTCTGATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6393754632600368					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898633	181898683	182180845	182180895	20800	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-10				AATTAGTGCTGCAGAGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57564904476967294					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898489	181898539	182180701	182180751	20801	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-11				CTCCCTCTTATCCCAACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090740384629969181					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898791	181898841	182181003	182181053	20802	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-12				TGGCACTCAAATGAAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.102983460811661					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898530	181898580	182180742	182180792	20803	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-13				GATAATAGTTCACAATCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.7447431598023719					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898465	181898515	182180677	182180727	20804	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-14				TTTGGCTGAGCATTTCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49646719374527287					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898864	181898914	182181076	182181126	20805	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-15				TGTTTCTTTTAACCTGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.170345006846933					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898570	181898620	182180782	182180832	20806	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-16				GAAACTTCCTTGTGCACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073865895254755551					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898477	181898527	182180689	182180739	20807	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-17				TTTCTCTCTGGCCCCTGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.248110389130402					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898668	181898718	182180880	182180930	20808	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-18				AAACAGTAGTTGATAAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32075914437039371					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898820	181898870	182181032	182181082	20809	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-19				AAATCAAGTAATGTTCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5605735407977912					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898372	181898422	182180584	182180634	20810	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-2				TTGCGATTACATAGGACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23619913542214999					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898771	181898821	182180983	182181033	20811	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-20				ATCTGTTATCAGAGTGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45929039774735592					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898605	181898655	182180817	182180867	20812	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-21				TTGAACTGCTCTTCAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.431727731338334					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898722	181898772	182180934	182180984	20813	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-3				GATAACGGGCGAGTCCCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0078792816742444382					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898554	181898604	182180766	182180816	20814	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-4				TACCTTGTTATCTGAGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.057862964722477692					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898516	181898566	182180728	182180778	20815	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-5				ATCCTTTGGCTAATGCAAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36147501172221569					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898426	181898476	182180638	182180688	20816	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-6				ATCTTCAGTGGTAAAAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28736094757476632					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898736	181898786	182180948	182180998	20817	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-7				TTCATATCTCACTGCCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66112136509913522					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898592	181898642	182180804	182180854	20818	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-8				AGCAGTTCAACCATTAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1709261265322323					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181898438	181898488	182180650	182180700	20819	hg38	N/A	enh54516	N/A	Enhatls129697	enhancer	SOX2e-12-9				CAAAATACCATGATCTTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.4257103715026227					SOX2	chr3	181711924	181714436	462462				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930424	181930474	182212636	182212686	20820	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-1				ACGTTTGCCGAGTGACTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44612406701648311					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930562	181930612	182212774	182212824	20821	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-10				GGGAGATTACAAAATCCATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038277584337331728					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930326	181930376	182212538	182212588	20822	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-11				AGTAATCCCATGAATTAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74406521790658431					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930509	181930559	182212721	182212771	20823	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-12				GTCATTAATGTCATTATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.054855877607989531					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930472	181930522	182212684	182212734	20824	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-13				CAGGGGATGCACTTGGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02082995913634364					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930446	181930496	182212658	182212708	20825	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-14				TTAGCAAGGAGAAGCCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.185062124160338					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930365	181930415	182212577	182212627	20826	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-15				CTGGGATGTGGAAGACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24921770344576741					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930491	181930541	182212703	182212753	20827	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-16				CTGGCTCTCTCTCGCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.133064815012424					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930403	181930453	182212615	182212665	20828	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-2				GGTGAATCATCGGTTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.038722793379638978					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930460	181930510	182212672	182212722	20829	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-3				TGCATCCCCTGTATCCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055133126771745963					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930383	181930433	182212595	182212645	20830	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-4				AGGTGTAAGCTTGGGAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55238722558648978					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930353	181930403	182212565	182212615	20831	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-5				CATTTGCCCCCACTGGGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41868222191886068					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930549	181930599	182212761	182212811	20832	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-6				GTAATCTCCCACTTTGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.115071957987853					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930295	181930345	182212507	182212557	20833	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-7				TACAGTCAAATTAAGTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1797573100536819					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930536	181930586	182212748	182212798	20834	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-8				TTGTGACTGGGTGAGCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55301682044852474					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181930581	181930631	182212793	182212843	20835	hg38	N/A	enh36202	N/A	Enhatls129697	enhancer	SOX2e-13-9				GTGGCAGCTGATTTCCTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1211217233644714					SOX2	chr3	181711924	181714436	495798				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956128	181956178	182238340	182238390	20836	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-1				TGCATCGGCACGCCGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.833268595888833					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956113	181956163	182238325	182238375	20837	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-10				GAATTCTTACATCAGTGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19897647153226389					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956027	181956077	182238239	182238289	20838	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-11				TCAGTCCACTGAAGTGGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.066423969351089893					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956209	181956259	182238421	182238471	20839	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-12				GCTGAACTCTCAGGCCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.760356870506536					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956140	181956190	182238352	182238402	20840	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-13				TGTCCCCATGAGCCCCACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2250799891975396					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956244	181956294	182238456	182238506	20841	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-14				AAATAACAGGGAAACTCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.06549021009031715					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956292	181956342	182238504	182238554	20842	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-15				CACAGATGAACACAGCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27344974830416369					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181955973	181956023	182238185	182238235	20843	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-16				ATTAATTAAAGCTTCTTATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.388330659863398					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956039	181956089	182238251	182238301	20844	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-17				AGTGGAAAAGGGGGTTGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60363469838396822					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956259	181956309	182238471	182238521	20845	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-18				TGTTATTTGTCTACTTTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20604138396013219					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956195	181956245	182238407	182238457	20846	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-2				CAGAATCCCGCATCCCGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.081918412190538664					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956228	181956278	182238440	182238490	20847	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-3				CAGCTGTATTAAGGGGCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46796452293822222					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956276	181956326	182238488	182238538	20848	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-4				TTGAGGATTAGAACTTCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30974239764883571					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956165	181956215	182238377	182238427	20849	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-5				CAAAATAGCAACCCCAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25187141714539091					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956077	181956127	182238289	182238339	20850	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-6				TCAGAAGGGCCCAGATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.160893085048294					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956091	181956141	182238303	182238353	20851	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-7				CCCTTCTGAGCAAGCTCATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.090433778637343323					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956178	181956228	182238390	182238440	20852	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-8				ATTCTGAGCAGTGCCGGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39125644251565239					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	181956062	181956112	182238274	182238324	20853	hg38	N/A	enh45580	N/A	Enhatls129697	enhancer	SOX2e-14-9				TTAGCTGGGTTGCTAGGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036850032258096313					SOX2	chr3	181711924	181714436	517668				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060167	182060217	182342379	182342429	20854	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-1				ATTGATGCGGTGACAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40654271974278289					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060260	182060310	182342472	182342522	20855	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-10				TGCAGTCAGTTGTGAAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034377123646408228					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060474	182060524	182342686	182342736	20856	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-11				ACAAACTAAAGGTGTCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1499160892498845					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060295	182060345	182342507	182342557	20857	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-12				CCTGTAACCTTGAAAACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40363411690538031					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060180	182060230	182342392	182342442	20858	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-13				TGCTCCAGGGCTGATTGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.078014283250373351					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060310	182060360	182342522	182342572	20859	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-14				ACTACAGGAATGTCACAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1126016432654092					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060368	182060418	182342580	182342630	20860	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-15				TGAAGGAGGGGTCAATGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.001566520954732308					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060339	182060389	182342551	182342601	20861	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-16				AGGAGATGCAGATGTGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.041392286740362529					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060149	182060199	182342361	182342411	20862	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-17				AGTGGGTCTCCTGCAGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63865470956886072					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060091	182060141	182342303	182342353	20863	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-18				TATGAGTCAAGCAGAAAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0203191379994581					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060485	182060535	182342697	182342747	20864	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-19				GTGTCACAGAGGTGAAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27176114457014711					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060227	182060277	182342439	182342489	20865	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-2				TTCCACACTGCAATCACAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2013751653838553					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060381	182060431	182342593	182342643	20866	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-20				ATGAAGATTTGGGTGAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22289393349391259					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060395	182060445	182342607	182342657	20867	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-21				AATCTTCATTCTTCTCAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31518445680675489					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060463	182060513	182342675	182342725	20868	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-22				AAGCCAAAAGGACAAACTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29937326736904613					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060125	182060175	182342337	182342387	20869	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-3				ACTAGTGAGGTCCTAAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.31828669957645639					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060451	182060501	182342663	182342713	20870	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-4				GAATCTGGCTACAAGCCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22931578822065779					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060112	182060162	182342324	182342374	20871	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-5				GGTTGTCAACAGTACTAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.69456066340266					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060193	182060243	182342405	182342455	20872	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-6				GATAATAACAGCATGCTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20074543074850229					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060436	182060486	182342648	182342698	20873	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-7				GCTGTGTGAGCACAAGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02679098408690684					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060414	182060464	182342626	182342676	20874	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-8				TTGGAAGATAGTCATGAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39236797349171149					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182060136	182060186	182342348	182342398	20875	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-15-9				GAGACCCACTGCCAAGACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0383446657136107					ATP11B	chr3	182793502	182921629	446646				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144474	182144524	182426686	182426736	20876	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-1				CAGACAGGGACATTTAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0242607261776091					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144325	182144375	182426537	182426587	20877	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-14				GCCATTGCCCAGGCTTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37559715833131818					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144599	182144649	182426811	182426861	20878	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-18				CTGGGGGGTGCCTCCCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18627969996056559					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144582	182144632	182426794	182426844	20879	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-2				GTTAGGCTGCTTGGGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3569862791364371					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144342	182144392	182426554	182426604	20880	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-20				CTTAGGTAAACAAAGCAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16820625288756921					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144183	182144233	182426395	182426445	20881	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-3				TGGTGCGCCATTTTTTAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.10331590746445229					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144205	182144255	182426417	182426467	20882	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-4				ACGAGATTATATCCCTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29856652151297558					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144381	182144431	182426593	182426643	20883	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-5				GAGCCCGCCACAGCTCAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32955655336187523					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144424	182144474	182426636	182426686	20884	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-6				CTGTGCCCTTCCCCCAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.98974343274802734					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144399	182144449	182426611	182426661	20885	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-7				GGAGGCCTGCTTGCCTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77246390753283156					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144355	182144405	182426567	182426617	20886	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-8				AGCAGCAGGGAAGCTCGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.38163797570203					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144564	182144614	182426776	182426826	20887	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16-9				AGGGGTCAGGGACGCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3870517863349302					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121206	chr3	182144245	182144295	182426457	182426507	20888	hg38	N/A	N/A	N/A	Enhatls129697	enhancer	SOX2e-16/EOMESe+5				TAGCAATCAGCGAGACTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73138475414400517					ATP11B	chr3	182793502	182921629	362741				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9335
enhrx-121209	chr3	182169168	182169218	182451380	182451430	20889	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-1				GCAATAGCCCGCAGATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16951099427131669					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168952	182169002	182451164	182451214	20890	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-10				GTAAATACCACAGTTTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66922395009032531					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169092	182169142	182451304	182451354	20891	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-11				GCCTCAGATAGTGGATAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1377087992187252					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168819	182168869	182451031	182451081	20892	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-12				CTAAATCAGGCAAAACTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1326334074713271					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169015	182169065	182451227	182451277	20893	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-13				GTAGTGGGTGAGTCTGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.315751738776291					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169191	182169241	182451403	182451453	20894	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-14				CTGGGGCTCAGTCCCGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54454834712354128					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168993	182169043	182451205	182451255	20895	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-15				GGCTGAAACAAAAAAGTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18954975785840261					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168836	182168886	182451048	182451098	20896	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-16				TCTCATTAGTTAACATTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13022630753917089					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169118	182169168	182451330	182451380	20897	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-17				AGTAAGAGAGACAGGACTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46846848148362319					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169130	182169180	182451342	182451392	20898	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-18				AGGACTCATGGAGAAGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38788704996833451					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168883	182168933	182451095	182451145	20899	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-19				ATGAAAGAGAAAGACAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.088474712152999388					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168797	182168847	182451009	182451059	20900	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-2				GATAGTATCATGCTAGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.136368241091567					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168761	182168811	182450973	182451023	20901	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-20				ATTTTCAGTTAAATGTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4693847149827319					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169071	182169121	182451283	182451333	20902	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-21				GGGGTGGAAGAGAGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.075692743117241612					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182169049	182169099	182451261	182451311	20903	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-3				GCATGCATGCTGGGACTATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0041527774505863034					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168898	182168948	182451110	182451160	20904	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-4				AGCTAAGGATAGGATAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.267322427038949					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168929	182168979	182451141	182451191	20905	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-5				GGGTTAGATAGGGCCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79851296264194116					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168972	182169022	182451184	182451234	20906	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-6				TACAAGTGCTGGATGGGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1869774259276584					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168857	182168907	182451069	182451119	20907	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-7				GAAAAGGAACCACGCCTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41496851054636608					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168909	182168959	182451121	182451171	20908	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-8				GGATAGTGCAGGGATAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47986267955318118					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182168871	182168921	182451083	182451133	20909	hg38	N/A	N/A	N/A	Enhatls129700	enhancer	SOX2e-17-9				TTCTCTTTCATGTGCCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2843558371597949					ATP11B	chr3	182793502	182921629	326726				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218286	182218336	182500498	182500548	20910	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-1				AAAGCGAGCGCCCTGATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24158633720243861					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218441	182218491	182500653	182500703	20911	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-10				GACAACAGTTTGAGATGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.031426932689055942					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218258	182218308	182500470	182500520	20912	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-11				AATTAGCAATGTTAATGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.74296880753521033					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218376	182218426	182500588	182500638	20913	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-12				TGCTTTCATTCTACCTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.098979299402988566					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218181	182218231	182500393	182500443	20914	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-13				GTCACTGGGAATGGATTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1107021070081291					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218020	182218070	182500232	182500282	20915	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-14				TCTACCTTTGAGCTTTTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4928061665540856					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218363	182218413	182500575	182500625	20916	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-15				TGTTTCATTACCTCCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22511320750032679					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218153	182218203	182500365	182500415	20917	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-16				GCTTCATTACTGGCAGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.320360509407314					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218153	182218203	182500365	182500415	20918	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-16				GCTTCATTACTGGCAGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.320360509407314					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218331	182218381	182500543	182500593	20919	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-17				TTCACTTGGTTCCTCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15899558812887529					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218331	182218381	182500543	182500593	20920	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-17				TTCACTTGGTTCCTCTGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15899558812887529					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218117	182218167	182500329	182500379	20921	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-18				ACTCCCGGGAGAGGCGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33174666434283528					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218117	182218167	182500329	182500379	20922	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-18				ACTCCCGGGAGAGGCGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33174666434283528					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218345	182218395	182500557	182500607	20923	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-19				AAACAATCTTCTTATTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.000607571204814087					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218130	182218180	182500342	182500392	20924	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-2				TCCCGGGAGTAACGAGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43803079987845128					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218130	182218180	182500342	182500392	20925	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-2				TCCCGGGAGTAACGAGCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43803079987845128					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218485	182218535	182500697	182500747	20926	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-20				GGCAGACAGCTCAGGTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53672059852179033					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218166	182218216	182500378	182500428	20927	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-21				CAGCTGAGGGGAAGGGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218275	182218325	182500487	182500537	20928	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-22				CTAATTAGCAGCCATTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27688559915851008					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218415	182218465	182500627	182500677	20929	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-23				GATGAGATGGATTAAGGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67866894346987938					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218103	182218153	182500315	182500365	20930	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-24				CGCAGGAGGAGACCTGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.548054216184062					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218467	182218517	182500679	182500729	20931	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-25				GGGGGTGGACGGAGGGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.0404118612852651					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218452	182218502	182500664	182500714	20932	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-26				GAGATGAGCTGGGGAGGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	14.08878857542863					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218320	182218370	182500532	182500582	20933	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-3				GTTGCATGTCACCGGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.11841176259973					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218320	182218370	182500532	182500582	20934	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-3				GTTGCATGTCACCGGCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.11841176259973					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218240	182218290	182500452	182500502	20935	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-4				TGGCCGTACTCTCGGACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00870111531984371					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218214	182218264	182500426	182500476	20936	hg38	N/A	enh71028	fant14402	Enhatls129702	enhancer	SOX2e-18-5				AGCGATCACTCCATGCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20404856919406281					ATP11B	chr3	182793502	182921629	292953				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218066	182218116	182500278	182500328	20937	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-6				TGGAAGACCTACTAGACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.075464230012721983					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218403	182218453	182500615	182500665	20938	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-7				TCCATCTCATCTTGAGCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.200943561488017					ATP11B	chr3	182793502	182921629	289305				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218046	182218096	182500258	182500308	20939	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-8				GAAATGCTAACCTTAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182218084	182218134	182500296	182500346	20940	hg38	N/A	enh71028	N/A	Enhatls129702	enhancer	SOX2e-18-9				CTGGGACCCAAACCCTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29754504628636008					ATP11B	chr3	182793502	182921629	293129				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434187	182434237	182716399	182716449	20941	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-1				GGGGGGAAATATGTTATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1142991004107813					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433909	182433959	182716121	182716171	20942	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-10				AGCACATTCCTTTCCCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33257214808897589					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433972	182434022	182716184	182716234	20943	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-11				GTGAAGTTTGGTGATTACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80391273941086472					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434092	182434142	182716304	182716354	20944	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-12				GAACTGCATGAGATTAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2674458597126228					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434123	182434173	182716335	182716385	20945	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-13				CTGAGCTGCTTTTTGTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.5059236810446992					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434168	182434218	182716380	182716430	20946	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-14				GAGGCAGAGAGAAATTATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38597080357351682					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434038	182434088	182716250	182716300	20947	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-15				GTTTTACTGTTTGCTCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.089862379146120844					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433751	182433801	182715963	182716013	20948	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-16				AAAAAAAAGAATTAATAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55359663712279661					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433827	182433877	182716039	182716089	20949	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-17				GCCGAGGTGGGCGGATCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.106222072499607					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433804	182433854	182716016	182716066	20950	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-18				TCAGGAGATCGAGACCATCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.609161844023772					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433853	182433903	182716065	182716115	20951	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-19				AGCCTGTAATCCCAGCACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.2691302557767976					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433786	182433836	182715998	182716048	20952	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-2				AGAAAGCACCCGTGTTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092150546646768625					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433839	182433889	182716051	182716101	20953	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-20				GCACTTTGGGAGGCCGAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.1155124940054408					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433896	182433946	182716108	182716158	20954	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-3				CTATCTTAGTACACCTAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21263967964818059					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434157	182434207	182716369	182716419	20955	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-4				AAATTATTTAGGTGAGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.219726534919408					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433989	182434039	182716201	182716251	20956	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-5				GGAGCTGGGGAAAATCTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62231003030008181					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433948	182433998	182716160	182716210	20957	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-6				TTCACTGAGACCCACTGTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.20887150391283521					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434003	182434053	182716215	182716265	20958	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-7				GCTCCCACACAGAAGGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2743786243640266					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182433959	182434009	182716171	182716221	20959	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-8				CAAACTTCACACCTATACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.711172271327207					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121209	chr3	182434140	182434190	182716352	182716402	20960	hg38	N/A	enh54522	N/A	Enhatls129702	enhancer	SOX2e-19-9				AAAAGGAAAGTTTTCTGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25780910740342472					ATP11B	chr3	182793502	182921629	69547				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9338
enhrx-121200	chr3	181473891	181473941	181756103	181756153	20961	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-1				GACCTATCTAACGCAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81096656292960745					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473891	181473941	181756103	181756153	20962	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-1				GACCTATCTAACGCAAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.81096656292960745					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473815	181473865	181756027	181756077	20963	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-10				TGATGTTTGAGGTTTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.023762537966467					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474100	181474150	181756312	181756362	20964	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-11				CTTTGAATGCATAGGTTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19427743172375381					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474036	181474086	181756248	181756298	20965	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-12				AGAACTATGGAAAGGAGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.036286356153049933					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474008	181474058	181756220	181756270	20966	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-13				TAAATGTTATTATGCAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515752					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473858	181473908	181756070	181756120	20967	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-14				AGCAGTAATTGTTTCTATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1121253338191559					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473826	181473876	181756038	181756088	20968	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-15				AAGGGAAACACTGATGTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2844824277237411					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473950	181474000	181756162	181756212	20969	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-2				GGTTGAAGTACTGTATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.017697205349166131					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473987	181474037	181756199	181756249	20970	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-3				TACATCATACAGGGCTCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74578580753726376					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473918	181473968	181756130	181756180	20971	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-4				GCCTACAATTCAATACTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.051592003046917752					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473918	181473968	181756130	181756180	20972	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-4				GCCTACAATTCAATACTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.051592003046917752					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473845	181473895	181756057	181756107	20973	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-5				TCTATTTTGGTATTTCGGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24739169152981419					SOX2	chr3	181711924	181714436	35713				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473932	181473982	181756144	181756194	20974	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-6				ATTGTAGGCTCTTGTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.574536803373711					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181473972	181474022	181756184	181756234	20975	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-7				TCCGCAGGCAAAGGTAAACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29829197251119371					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474054	181474104	181756266	181756316	20976	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-8				GTTCTTTGATATTACTTAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.1530010413132414					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474156	181474206	181756368	181756418	20977	hg38	N/A	enh77150	fant14389	Enhatls129689	enhancer	SOX2e-2-9				GTATTGATCTTATTTAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.357587523427954					SOX2	chr3	181711924	181714436	41705				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474156	181474206	181756368	181756418	20978	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-2-9				GTATTGATCTTATTTAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	4.357587523427954					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121240	chr3	182727677	182727727	183009889	183009939	20979	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-1				AGTTTAGCGAAATGGTAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22379699940930031					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727941	182727991	183010153	183010203	20980	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-10				ACCATGCCTTCTGGACCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18463381917279059					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727545	182727595	183009757	183009807	20981	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-11				GACATAGTTGGTCATGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.7519887133462112					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728067	182728117	183010279	183010329	20982	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-12				GCCCTATACTCCCAGTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70517154622443767					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728078	182728128	183010290	183010340	20983	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-13				GTAGTTTTTCCCCACCAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0157997380384849					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727824	182727874	183010036	183010086	20984	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-14				AATGCCTTGGTGCCTCTAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65860468077181877					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728157	182728207	183010369	183010419	20985	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-15				AGGAGGGGACTGGTACCCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1603682122451536					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728089	182728139	183010301	183010351	20986	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-16				GGGAAAAACTACTAACCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30940283805039809					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727966	182728016	183010178	183010228	20987	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-17				AACCCCTGGGAATGTCCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39847888677714649					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727501	182727551	183009713	183009763	20988	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-18				TAACTGCCTGCTTTCAATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1487565483032936					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727838	182727888	183010050	183010100	20989	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-19				CAAGGCATTCTGAGTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.57154236731907782					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728056	182728106	183010268	183010318	20990	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-2				GGAGTATAGGGCATCACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.053141060154667748					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727866	182727916	183010078	183010128	20991	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-20				GCAAATGGGAGACAAATGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24258243439418151					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727780	182727830	183009992	183010042	20992	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-21				AGGAGAGTGCACACTTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022690642747692572					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727780	182727830	183009992	183010042	20993	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-21				AGGAGAGTGCACACTTCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.022690642747692572					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728005	182728055	183010217	183010267	20994	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-22				GAGTGTTTCCACTCAGCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20504210953913141					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727855	182727905	183010067	183010117	20995	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-23				TCTCCCATTTGCTGGATCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.92995781334021077					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728021	182728071	183010233	183010283	20996	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-24				CTGTCAGCTCTCAAAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0064205991728724524					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727812	182727862	183010024	183010074	20997	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-25				CAGGAGACTGAGCCAGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51380825482289039					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727926	182727976	183010138	183010188	20998	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-26				CTAAAGGCCCAGGCACCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46652174035617172					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727595	182727645	183009807	183009857	20999	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-27				AATTACCCTGTTTTTGTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28421152150940188					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727530	182727580	183009742	183009792	21000	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-28				ACTATGTCATAAAAGCATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70546958794154779					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728032	182728082	183010244	183010294	21001	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-29				GAGAGCTGACAGCTGTGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18996038859283779					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727743	182727793	183009955	183010005	21002	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-3				GGGAGTTAACGTCTGTGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.50226515582560116					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728120	182728170	183010332	183010382	21003	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-30				GTTCCCTCAGGGCTGACCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.975482339677394					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727625	182727675	183009837	183009887	21004	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-31				TTTCTGTGGGAAGCTGGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63158885924161035					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727562	182727612	183009774	183009824	21005	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-32				TGAAGGAATAACTGGGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33454701097038553					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727754	182727804	183009966	183010016	21006	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-33				TCTGTGCTGTGGCTTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83217575623785978					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727754	182727804	183009966	183010016	21007	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-33				TCTGTGCTGTGGCTTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83217575623785978					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727611	182727661	183009823	183009873	21008	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-34				TTAGTGGTTTTTTGTTTCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.276765984491271					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727979	182728029	183010191	183010241	21009	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-35				CCCAGGGGTTGGGGGAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.325267490791262					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727718	182727768	183009930	183009980	21010	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-4				TGACGTCAGCCATTCTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0458006481256771					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727910	182727960	183010122	183010172	21011	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-5				TCAGGGTTATAATCTCCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34309166149420628					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727893	182727943	183010105	183010155	21012	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-6				CAAGGTAATCATTGGTATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52196073626339146					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727793	182727843	183010005	183010055	21013	hg38	N/A	enh91507	fant14414	Enhatls129733	enhancer	SOX2e-20-7				CTTCACTTGGAACTCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069179038275203469					MCCC1	chr3	183015217	183116075	5209				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182727793	182727843	183010005	183010055	21014	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-7				CTTCACTTGGAACTCGCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.069179038275203469					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728137	182728187	183010349	183010399	21015	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-8				GGGAACAGTATGTTATTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36112802556624729					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121240	chr3	182728103	182728153	183010315	183010365	21016	hg38	N/A	enh91507	N/A	Enhatls129733	enhancer	SOX2e-20-9				ACCTCTAGGGGCAGCACCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.255347624423389					MCCC1	chr3	183015217	183116075	2907				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9369
enhrx-121259	chr3	182832140	182832190	183114352	183114402	21017	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-1				GACGGCTAACGCTCAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3564266408740927					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832158	182832208	183114370	183114420	21018	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-10				ATTAGCCAGCGACCGAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.092287128675049651					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831952	182832002	183114164	183114214	21019	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-11				GGTGATAGACACAGGGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.006368027299998					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832188	182832238	183114400	183114450	21020	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-13				TTTTAATTCATCTCAAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32627016316022223					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831820	182831870	183114032	183114082	21021	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-15				CACTGGCAGCCTCTTCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.3257619532487386					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832025	182832075	183114237	183114287	21022	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-16				CAAAAAGGTAAAAGGATAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.1139418906942251					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831885	182831935	183114097	183114147	21023	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-17				AATTAACGGATAAGATACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0855086427624721					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831835	182831885	183114047	183114097	21024	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-19				TTGCACAAGTTAAGTCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50051174217561789					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832127	182832177	183114339	183114389	21025	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-2				CAAAATTTGGCCCCAAGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20726561391407261					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832040	182832090	183114252	183114302	21026	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-3				CAGAAGTTAAGTAGTCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832089	182832139	183114301	183114351	21027	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-4				ACATCTTGGTTTAGGAAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2949986670506855					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831871	182831921	183114083	183114133	21028	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-5				ACATCCAAGAATGCAATTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1467568355754951					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831918	182831968	183114130	183114180	21029	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-6				AGACGAATTCTTGGGCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052070107957899507					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832116	182832166	183114328	183114378	21030	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-7				GTTAATCAAGCCCCTTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47720839285973582					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832103	182832153	183114315	183114365	21031	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-8				CTTGATTAACTTTTACATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0067526886500265167					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182831791	182831841	183114003	183114053	21032	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21-9				GAACAAGACAAACTCCATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19043750271044119					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182832000	182832050	183114212	183114262	21033	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-21/-24				ACAGGAAAGTAAACAGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4211371493397791					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833895	182833945	183116107	183116157	21034	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-1				CGGCCAATGGGGGGCTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.49699887066309062					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833909	182833959	183116121	183116171	21035	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-10				CTAAAGGGGCTTGTTGTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.36911487898772588					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834177	182834227	183116389	183116439	21036	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-11				CAGGCGCAGCCAGTCCGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.052465993884368928					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834134	182834184	183116346	183116396	21037	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-12				TTTCCCCTGCCCGTGCGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.407780815358764					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833847	182833897	183116059	183116109	21038	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-13				AACCCTCAGAAGCCTCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15833298908103249					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834027	182834077	183116239	183116289	21039	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-14				CTGCACCGGCAGGGGAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26681227298546961					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833942	182833992	183116154	183116204	21040	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-15				TGATCTATATGCTGCACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.210048890329881					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834100	182834150	183116312	183116362	21041	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-16				GTTCCCCTGCCCGTGAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22991910857694939					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834270	182834320	183116482	183116532	21042	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-17				GTTCCCCTGCCCGTGCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73372667213946619					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833958	182834008	183116170	183116220	21043	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-18				CGCATGAGCAGGAGAGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.036309883308474407					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833829	182833879	183116041	183116091	21044	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-19				GGGTTTCCTAGGGGTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25924941937271762					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833883	182833933	183116095	183116145	21045	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-2				AGGACTGGCCGGCGGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.193446602928185					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834196	182834246	183116408	183116458	21046	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-20				CGCACGGGCAGGGAAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12559695175160021					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834231	182834281	183116443	183116493	21047	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-21				CTGCTGTTCCCCTGCCCGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.077378043947419331					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834163	182834213	183116375	183116425	21048	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-22				CTGCTATTCCCCTGCCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40566134552866973					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833993	182834043	183116205	183116255	21049	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-23				GCGCATGGGCAGGGGAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33544294053924861					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834041	182834091	183116253	183116303	21050	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-24				CAGGTGCAGCCAGTCTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0630713622426503					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833859	182833909	183116071	183116121	21051	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-25				CATGGGGTGTGGCCAATTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0121286589738722					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833790	182833840	183116002	183116052	21052	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-26				TTTAAAAAAAACCCTACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.70205288708584956					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833779	182833829	183115991	183116041	21053	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-3				CTGAAGAGCCCCCTCAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.00074933248557340724					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834007	182834057	183116219	183116269	21054	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-4				CGGGTGCAGTCAGTGCGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37949103274196128					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834245	182834295	183116457	183116507	21055	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-5				TAGGTGCAGCCAGTCCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27550085074826969					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833969	182834019	183116181	183116231	21056	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-6				TGCAGTCAGTGCGCATGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.031840202448394243					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834066	182834116	183116278	183116328	21057	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-7				GTTCCCCTACCCGTGCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1184539387893707					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182834211	182834261	183116423	183116473	21058	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-8				CAGGCGCAGTCAGTGCGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40802862418036351					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121259	chr3	182833872	182833922	183116084	183116134	21059	hg38	N/A	N/A	N/A	Enhatls129752	enhancer	SOX2e-22-9				ACACCCCATGAAGGACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.53495735618042239					MCCC1	chr3	183015217	183116075	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9388
enhrx-121281	chr3	182983181	182983231	183265393	183265443	21060	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-1				TACCAGATCGGCAGGCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0925822206817025					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983181	182983231	183265393	183265443	21061	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-1				TACCAGATCGGCAGGCTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0925822206817025					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983033	182983083	183265245	183265295	21062	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-10				TGAGTTTCTAGTCTGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3977164775819978					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983033	182983083	183265245	183265295	21063	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-10				TGAGTTTCTAGTCTGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3977164775819978					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983193	182983243	183265405	183265455	21064	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-11				AGGCTTGTGGGCTTCTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.229799341809793					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983193	182983243	183265405	183265455	21065	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-11				AGGCTTGTGGGCTTCTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.229799341809793					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983167	182983217	183265379	183265429	21066	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-12				GATCTGGTAGAAGAAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20674853147429689					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983167	182983217	183265379	183265429	21067	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-12				GATCTGGTAGAAGAAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20674853147429689					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983277	182983327	183265489	183265539	21068	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-13				CTCACTCTTCTGGTTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29599823714171081					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983277	182983327	183265489	183265539	21069	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-13				CTCACTCTTCTGGTTTCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29599823714171081					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983143	182983193	183265355	183265405	21070	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-14				GGCTTGCTTTGTTTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2211126953379654					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983143	182983193	183265355	183265405	21071	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-14				GGCTTGCTTTGTTTCCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2211126953379654					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983210	182983260	183265422	183265472	21072	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-15				AGAGTGCAGGGGAGGGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73656910855353186					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983210	182983260	183265422	183265472	21073	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-15				AGAGTGCAGGGGAGGGACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73656910855353186					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983121	182983171	183265333	183265383	21074	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-2				CTGAGCTGCGCATTCGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092277972112501022					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983121	182983171	183265333	183265383	21075	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-2				CTGAGCTGCGCATTCGGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092277972112501022					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983015	182983065	183265227	183265277	21076	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-3				ACTCAAGGGTTACCCCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.93920149162095035					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983015	182983065	183265227	183265277	21077	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-3				ACTCAAGGGTTACCCCTGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.93920149162095035					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983322	182983372	183265534	183265584	21078	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-4				TCCATCCGCAAAGCCGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2303404973118269					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983322	182983372	183265534	183265584	21079	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-4				TCCATCCGCAAAGCCGGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2303404973118269					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983297	182983347	183265509	183265559	21080	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-5				GAGCGCCAGTTGTATGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60274119209066745					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983297	182983347	183265509	183265559	21081	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-5				GAGCGCCAGTTGTATGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60274119209066745					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983091	182983141	183265303	183265353	21082	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-6				GCACCCACAGCAGTCTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15758367963495651					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983091	182983141	183265303	183265353	21083	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-6				GCACCCACAGCAGTCTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15758367963495651					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983335	182983385	183265547	183265597	21084	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-7				AACACTGTTGCGCCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42333301933077372					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983335	182983385	183265547	183265597	21085	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-7				AACACTGTTGCGCCCAGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42333301933077372					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983221	182983271	183265433	183265483	21086	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-8				CTTTCCTATTCAGAGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1381906565806745					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983221	182983271	183265433	183265483	21087	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-8				CTTTCCTATTCAGAGTGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1381906565806745					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983056	182983106	183265268	183265318	21088	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-9				GTGCCTGCAGCACGGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19717030883674139					B3GNT5	chr3	183253252	183273385	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121281	chr3	182983056	182983106	183265268	183265318	21089	hg38	N/A	enh63245	N/A	Enhatls129775	enhancer	SOX2e-23-9				GTGCCTGCAGCACGGGTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19717030883674139					MCF2L2	chr3	183178040	183428778	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9410
enhrx-121294	chr3	183152140	183152190	183434352	183434402	21090	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-1				AAAACAATCTAGCCCCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0131342973115082					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152539	183152589	183434751	183434801	21091	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-10				AAAAAGAAAGTCTAAAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.421537025648562					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152301	183152351	183434513	183434563	21092	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-11				AGGTGATAGACGCGGGGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.91565335479039456					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152205	183152255	183434417	183434467	21093	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-12				CAATTTTACAGAAGTAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47597249633115452					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152151	183152201	183434363	183434413	21094	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-14				CTAGATTGTTTTTTATACTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.72054637185311221					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152169	183152219	183434381	183434431	21095	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-17				TTTGGTTTAGAAAGGGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3845198111315229					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152236	183152286	183434448	183434498	21096	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-18				TTAAAAGGATAAATGGTTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.3528925346587419					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152459	183152509	183434671	183434721	21097	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-2				AGAGCCAAGATAAAGTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063225139467400493					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152128	183152178	183434340	183434390	21098	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-3				AAGTTCTCTCAGCCTTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068097802941610747					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152506	183152556	183434718	183434768	21099	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-4				GTTCAGGTAGAAACAAAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13676008991603941					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152490	183152540	183434702	183434752	21100	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-5				AGCTAAAAGAGAGTCAGTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41106390843509888					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152345	183152395	183434557	183434607	21101	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-6				GAGCTATATCCGCAGTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.055273712815053062					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152315	183152365	183434527	183434577	21102	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-7				GGGCTTTGGGCGTTATCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.217044740436364					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121294	chr3	183152327	183152377	183434539	183434589	21103	hg38	N/A	enh105507	N/A	Enhatls129792	enhancer	SOX2e-24-8				TTATCAATCGGACGAATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.595886289748772					MCF2L2	chr3	183178040	183428778	4495				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9423
enhrx-121302	chr3	183262792	183262842	183545004	183545054	21104	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-1				ACGGTTGGGAGTTTGCCTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0839122553979829					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262731	183262781	183544943	183544993	21105	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-10				TGAGGGACTTTCTCTACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5178804365303592					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262620	183262670	183544832	183544882	21106	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-11				CACAATGATCAGCCCAGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.13515933334495489					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262838	183262888	183545050	183545100	21107	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-12				CACTTGGCTTCTCTCAGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01674829564680376					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262648	183262698	183544860	183544910	21108	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-13				GGCCAATCACTGTGCCAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.02252199791315463					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262759	183262809	183544971	183545021	21109	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-14				ACTCCTAGCCTTGGCTCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.41562033460217079					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262699	183262749	183544911	183544961	21110	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-15				CCAATCAGAGTCTTTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32250327319767741					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262862	183262912	183545074	183545124	21111	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-16				GGGGTGGAGAAAGAGCACGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52824376598977862					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262495	183262545	183544707	183544757	21112	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-17				CAGAAGATAGAAAGGCGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.320873165672891					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262748	183262798	183544960	183545010	21113	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-18				TGGCTCTGGAGGGAAAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.7596788718059011					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262875	183262925	183545087	183545137	21114	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-2				AGCACGCAGGCTGCACGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.04754553459183259					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262807	183262857	183545019	183545069	21115	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-3				GCTGACTTCTGCCACACGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059459839775647692					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262777	183262827	183544989	183545039	21116	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-4				GGAGTCTCATAGCAGCCAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23036292978924461					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262607	183262657	183544819	183544869	21117	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-5				GGTGGACTCCTAACCTAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.047304891667439189					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262585	183262635	183544797	183544847	21118	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-6				CACGCACAGCTCTTTAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35703249682275218					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262715	183262765	183544927	183544977	21119	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-7				CCAGGGGTTTTTCAAGCCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33112588643932928					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262669	183262719	183544881	183544931	21120	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-8				CCTAGGATTGGGTAACTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0192216277647301					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183262634	183262684	183544846	183544896	21121	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-25-9				ATCATTGTGCCCCACCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.5849137888782641					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266280	183266330	183548492	183548542	21122	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-1				TAGAGACTGCGGTACAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.095202469028238312					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266077	183266127	183548289	183548339	21123	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-10				GCAGCCCTGCTGTGATTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02643176481606084					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266189	183266239	183548401	183548451	21124	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-11				ATAGAAAAGCTTCCAGGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1365682540617244					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266230	183266280	183548442	183548492	21125	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-12				CCTTTGTTGATGCTGCTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17234165673281171					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266092	183266142	183548304	183548354	21126	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-13				TTCCCAGGGTTGGCAGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.51723538448281					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266312	183266362	183548524	183548574	21127	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-2				GTCCTCTCAACATAGCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0788315817220686					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266248	183266298	183548460	183548510	21128	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-3				GGAATCCAGACAAGGATTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.52107314406100125					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266115	183266165	183548327	183548377	21129	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-4				GGAGTCCTAGTGATGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71446779610495237					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266291	183266341	183548503	183548553	21130	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-5				GGAACCAGACCTAGAGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59060876456131706					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266158	183266208	183548370	183548420	21131	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-6				GAAGGGCCAGTCATGAGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.256001598515654					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266201	183266251	183548413	183548463	21132	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-7				CTAATGACTCAGCCTCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1243493473985233					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266176	183266226	183548388	183548438	21133	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-8				GCTTTTCTATGCATGAAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.11747437916138059					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121302	chr3	183266269	183266319	183548481	183548531	21134	hg38	N/A	enh7729	N/A	N/A	enhancer	SOX2e-26-9				GTACAAGACAGGAGTGAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.92890002432321239					KLHL6	chr3	183487550	183555706	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9431
enhrx-121200	chr3	181474695	181474745	181756907	181756957	21135	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-1				GTTTCGCCCCTCCATTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29076573924962779					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474640	181474690	181756852	181756902	21136	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-10				CTCAGCATGGGCAAGATTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16890388398769471					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474923	181474973	181757135	181757185	21137	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-11				AGGTGAAGACTGTCTCTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37212771209768519					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474923	181474973	181757135	181757185	21138	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-11				AGGTGAAGACTGTCTCTATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.37212771209768519					SOX2	chr3	181711924	181714436	42746				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474379	181474429	181756591	181756641	21139	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-12				GGCAACACTTCACTGTGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13711739544958379					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474400	181474450	181756612	181756662	21140	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-13				TGCCTCTGACAGTATATATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57026803415063765					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474606	181474656	181756818	181756868	21141	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-14				GCAGACTGAAGAGTTTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.617186487776265					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474513	181474563	181756725	181756775	21142	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-15				GTAAAGGCTATTTTTAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.89554089598254549					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474538	181474588	181756750	181756800	21143	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-16				TTCAAGAGTGTATCAGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36508661430966571					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474444	181474494	181756656	181756706	21144	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-17				GCTAGAGGAAAAAAACCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1218707547944185					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474651	181474701	181756863	181756913	21145	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-18				CAAGATTGGGGGTGAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19028324023073079					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474584	181474634	181756796	181756846	21146	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-19				GGTGCAGGGCACTGCAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45208221360563811					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474584	181474634	181756796	181756846	21147	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-19				GGTGCAGGGCACTGCAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45208221360563811					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474784	181474834	181756996	181757046	21148	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-2				TGATTTGCAACCATGTAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.486868609176191					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474567	181474617	181756779	181756829	21149	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-20				TTTAGGATTTCTGCAGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0328785930829117					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474567	181474617	181756779	181756829	21150	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-20				TTTAGGATTTCTGCAGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0328785930829117					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474416	181474466	181756628	181756678	21151	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-21				AGAGGCAGCTGTAGCAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.6495218235469018					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474486	181474536	181756698	181756748	21152	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-22				TCAGCAATGAAATGGTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.9645605887426193					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474497	181474547	181756709	181756759	21153	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-23				ATGGTTAATAGGATGAGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22144111457708471					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474750	181474800	181756962	181757012	21154	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-24				GTCTATTTCTCTGTGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1919000274367092					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474883	181474933	181757095	181757145	21155	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-25				GCTTTTCTCCTCCACAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37260095267246168					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474735	181474785	181756947	181756997	21156	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-26				AAGGAACACAGAAACCCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34713302583172367					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474861	181474911	181757073	181757123	21157	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-27				GCAAAATTTTTAAGCTTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10571748679575289					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474938	181474988	181757150	181757200	21158	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-28				CTTCACCTTCAGCTTTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40138514687916638					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474938	181474988	181757150	181757200	21159	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-28				CTTCACCTTCAGCTTTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40138514687916638					SOX2	chr3	181711924	181714436	42746				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474716	181474766	181756928	181756978	21160	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-29				ACACTGAGATCCTGCAGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.015306472822894509					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474894	181474944	181757106	181757156	21161	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-3				GGTATAAGTGACCGCTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73255426458098494					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474671	181474721	181756883	181756933	21162	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-30				TGGAGGAGGGGCTCAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25904529565941431					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474429	181474479	181756641	181756691	21163	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-31				GCAATTTTGGAGTTTGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.45992335998881217					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474333	181474383	181756545	181756595	21164	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-32				ATTCACTACAGAAAGAACTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4715843775358519					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474807	181474857	181757019	181757069	21165	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-33				TAAATAAAATAACAGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.7520494671668161					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474773	181474823	181756985	181757035	21166	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-4				CATGTAACGGGGCTTTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.63596930167895949					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474628	181474678	181756840	181756890	21167	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-5				CTGTAAGTAAGCCTCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33485255005549569					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474824	181474874	181757036	181757086	21168	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-6				TATTTACTGTGGTCTGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.049885811494060892					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474459	181474509	181756671	181756721	21169	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-7				GCTTGTAAGGCAGGACCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1829663351258079					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474684	181474734	181756896	181756946	21170	hg38	N/A	enh77150	fant14390	Enhatls129689	enhancer	SOX2e-3-8				CAAGCCCTGGGCCTTTGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.241076038561954					SOX2	chr3	181711924	181714436	42372				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181474472	181474522	181756684	181756734	21171	hg38	N/A	enh77150	N/A	Enhatls129689	enhancer	SOX2e-3-9				CATTGCTGAACTGGCTTGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22802347435781661					SOX2	chr3	181711924	181714436	41971				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500476	181500526	181782688	181782738	21172	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-1				GGGACACATCATAAAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068188763120789642					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500476	181500526	181782688	181782738	21173	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-1				GGGACACATCATAAAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.068188763120789642					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500585	181500635	181782797	181782847	21174	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-10				TATCCATTGCTTCCTCTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25223340218155721					SOX2	chr3	181711924	181714436	68361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500448	181500498	181782660	181782710	21175	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-11				ATCTTCAGGGAGATAAAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.062011074052125921					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500562	181500612	181782774	181782824	21176	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-12				CAGGAAGCAGAATTCACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0033075449621665629					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500562	181500612	181782774	181782824	21177	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-12				CAGGAAGCAGAATTCACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0033075449621665629					SOX2	chr3	181711924	181714436	68361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500597	181500647	181782809	181782859	21178	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-13				GTTGTCAGTAAACCAGAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56664671178113946					SOX2	chr3	181711924	181714436	68361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500401	181500451	181782613	181782663	21179	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-14				TTTGGTATTTGTATTCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40148435466550542					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500621	181500671	181782833	181782883	21180	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-15				TTCTAATAGCTTTCTGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73372508668785164					SOX2	chr3	181711924	181714436	68361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500280	181500330	181782492	181782542	21181	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-16				AGAAAGAAAAAGCAATGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20944847838190619					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500346	181500396	181782558	181782608	21182	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-17				TTGCTTTGTTTTTCTTTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64028179214305692					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500320	181500370	181782532	181782582	21183	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-18				GAAAAAATAAAATAATTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.560537889132446					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500522	181500572	181782734	181782784	21184	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-2				GATTCCCTTCACTATCGCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.018351640932152431					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500551	181500601	181782763	181782813	21185	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-3				ATTCACACAGGGACTGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26795730365076					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500551	181500601	181782763	181782813	21186	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-3				ATTCACACAGGGACTGTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26795730365076					SOX2	chr3	181711924	181714436	68361				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500215	181500265	181782427	181782477	21187	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-4				TTTTTGCCTGGTCAGCATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27814749639766712					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500203	181500253	181782415	181782465	21188	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-5				CTTATGTCATAATTTTTGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22211332028618261					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500383	181500433	181782595	181782645	21189	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-6				TTAGTTCAATGTGTGCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.223763023726766					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500496	181500546	181782708	181782758	21190	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-7				GAGAGCAGCTAGTCCAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22203710147671879					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500496	181500546	181782708	181782758	21191	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-7				GAGAGCAGCTAGTCCAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22203710147671879					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500461	181500511	181782673	181782723	21192	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-8				GCTCCAGGAGAGAATCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40677757131642778					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500461	181500511	181782673	181782723	21193	hg38	N/A	enh36199	fant14391	Enhatls129689	enhancer	SOX2e-4-8				GCTCCAGGAGAGAATCTTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.40677757131642778					SOX2	chr3	181711924	181714436	68284				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181500191	181500241	181782403	181782453	21194	hg38	N/A	enh36199	N/A	Enhatls129689	enhancer	SOX2e-4-9				TATGACATAAGAATGTTGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2053879672442146					SOX2	chr3	181711924	181714436	65902				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514774	181514824	181796986	181797036	21195	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-1				TGACTCTATAGTAGGTGCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2628300575762561					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514536	181514586	181796748	181796798	21196	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-10				TTTGTTAGCAAAAATACTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51856909442480359					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514614	181514664	181796826	181796876	21197	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-11				TGTCATGTAATCCCAGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61353727303652261					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514704	181514754	181796916	181796966	21198	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-12				GTCTGGGAAGCAGGGGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19768500339085951					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514488	181514538	181796700	181796750	21199	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-13				GCAGGCAGAAATAAAAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30834674722021321					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514632	181514682	181796844	181796894	21200	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-14				CATCCAGCCTCTGCCTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.4375799357576915					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514395	181514445	181796607	181796657	21201	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-15				GGGTGGATTGCTTTGAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.083393290391814					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514456	181514506	181796668	181796718	21202	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-16				TTTCTCCAGGCCGGGCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1058411844794523					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514751	181514801	181796963	181797013	21203	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-17				TCTCGAGTGCTTGGGACTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61465635396475227					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514643	181514693	181796855	181796905	21204	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-18				AGAGGCTGGATGATCACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.15235740105344811					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514739	181514789	181796951	181797001	21205	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-19				AGCACTCGAGAGGCTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.83680519374955					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514602	181514652	181796814	181796864	21206	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-2				ATTACATGACAGTCAGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.082194219480744526					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514720	181514770	181796932	181796982	21207	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-20				CTGGAGAATCGCTTGAGTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.017586281121649491					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514418	181514468	181796630	181796680	21208	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-21				GCCTTGGCTTCCCAAAATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.034736377657597427					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514429	181514479	181796641	181796691	21209	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-22				TGCCTGTAATCCCAGCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.714394377071478					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514566	181514616	181796778	181796828	21210	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-3				CATTCAGAAGGGTCACAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058086363959709772					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514578	181514628	181796790	181796840	21211	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-4				AGGTTTTATTCACATTCAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57092987923636518					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514469	181514519	181796681	181796731	21212	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-5				TAGGCTTGAAAAATTTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19898065122096339					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514830	181514880	181797042	181797092	21213	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-6				GAATGAATTCATTAGGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57732864183621324					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514667	181514717	181796879	181796929	21214	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-7				ATGTTCATGTTCTTGAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40291824886144029					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514813	181514863	181797025	181797075	21215	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-8				AATATGACTGATTATTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36761024010721011					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181514506	181514556	181796718	181796768	21216	hg38	N/A	N/A	N/A	Enhatls129689	enhancer	SOX2e-5-9				AAAAAGCATCTAAGCAGGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32961760503153742					SOX2	chr3	181711924	181714436	78652				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576796	181576846	181859008	181859058	21217	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-1				CCGCAGTTAAGCGGGACTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.10845634523310781					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576781	181576831	181858993	181859043	21218	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-10				AACTGCGGTTTTGCTTTCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1152134845456709					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576937	181576987	181859149	181859199	21219	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-2				CATATACATACTGCTAACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2373302692800105					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576955	181577005	181859167	181859217	21220	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-3				AGTGGTTATCTTCGGAGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73876852474246046					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577092	181577142	181859304	181859354	21221	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-4				TATGATTCTAAAGTCTACCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.59839015060421308					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576765	181576815	181858977	181859027	21222	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-5				TCAATGGTTTCAGGTAAATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18051348760085931					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576893	181576943	181859105	181859155	21223	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-6				AATTTTAGATCCTAGATAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.026790984086907291					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576735	181576785	181858947	181858997	21224	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-7				AGGTATTTTCAGAGTGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29241175367054267					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577019	181577069	181859231	181859281	21225	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-8				ATTGCATTACTTTTGTAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.717877531943845					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181576851	181576901	181859063	181859113	21226	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-6-9				TGTTTATTTGCTTATATGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1899820324595209					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577587	181577637	181859799	181859849	21227	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-1				TGCCTACTCCGGGGTGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86327413760440985					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577304	181577354	181859516	181859566	21228	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-10				TAGCACCTTGAATGTGGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2571910568198798					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577452	181577502	181859664	181859714	21229	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-11				AATGCAGATTTTTGGTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2652127978636396					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577427	181577477	181859639	181859689	21230	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-12				CATTCATATTAACTTTTCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82029371778955873					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577368	181577418	181859580	181859630	21231	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-13				TTAATGCAAATAAGATAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2200827460257011					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577516	181577566	181859728	181859778	21232	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-14				GTGAAAGGAGCCTGTGGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13853148989999581					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577601	181577651	181859813	181859863	21233	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-15				TGAATTTGGCACATTTCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79563840570556377					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577576	181577626	181859788	181859838	21234	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-16				TTTCACCTTCCTGCCTACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64555168085251147					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577484	181577534	181859696	181859746	21235	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-17				ATACTAATTGAAGATAATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4382154161724561					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577561	181577611	181859773	181859823	21236	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-18				AGGTGAAAGGCTTGGAGGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39453034650780561					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577549	181577599	181859761	181859811	21237	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-19				TGGAGGCTGGGCTGAAAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67921191449302531					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577533	181577583	181859745	181859795	21238	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-2				AGGTTGGCGATTCAGCCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8592824046516061					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577315	181577365	181859527	181859577	21239	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-20				ATGTGGAGGAGGCCAAGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30515013492692777					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577693	181577743	181859905	181859955	21240	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-3				ACCATAAACTGGTGGAAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79510185908490438					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577650	181577700	181859862	181859912	21241	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-4				CACACGTTTAAACACAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.021109302865679					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577329	181577379	181859541	181859591	21242	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-5				AAGACTGGGTGAAGTCGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66232536231411276					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577347	181577397	181859559	181859609	21243	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-6				AAATTAACTCCAGCTACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70361487477964213					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577675	181577725	181859887	181859937	21244	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-7				ATGGTCTAGTGAGGGAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.147632991386133					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577501	181577551	181859713	181859763	21245	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-8				TAGTATTTACTGACAGTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095975100333378971					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181577402	181577452	181859614	181859664	21246	hg38	N/A	enh71021	N/A	Enhatls129689	enhancer	SOX2e-7-9				TATTTTGAGCCAGAGATTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.018110973531677808					SOX2	chr3	181711924	181714436	142709				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610726	181610776	181892938	181892988	21247	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-1				CGGTGTCTCAAAAGCCTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08644798822163					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610818	181610868	181893030	181893080	21248	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-10				CAGTATTTGAGTCTGAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14823395246007481					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610702	181610752	181892914	181892964	21249	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-11				ATTCCTCACATTTTATCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.090825039917629885					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610967	181611017	181893179	181893229	21250	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-12				AGCCACTGAGTTGTGCCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27457233083846888					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610837	181610887	181893049	181893099	21251	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-13				GAGGCAAGGTAGGGGGTTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32532351028385181					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610876	181610926	181893088	181893138	21252	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-14				GTGTGTGCATCAGGGAAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5822707493514736					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610795	181610845	181893007	181893057	21253	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-15				TCAGAGAAAGCTTAAGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.6467781377647972					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181611021	181611071	181893233	181893283	21254	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-16				GCAAGAGGAGCTGGTGGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52323780330709568					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610744	181610794	181892956	181893006	21255	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-2				CACCGTATGTGGGAATGTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21843838951393729					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610982	181611032	181893194	181893244	21256	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-3				TGATAAACGAGGGAACCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45089987765894213					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610772	181610822	181892984	181893034	21257	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-4				GAGGGTTCTTCTATTAGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.1622856937695909					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610993	181611043	181893205	181893255	21258	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-5				TGTCCTCACAGTGATAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64566129179417153					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610893	181610943	181893105	181893155	21259	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-6				GTATGGCCCATGTCTGAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.4815722320642051					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610937	181610987	181893149	181893199	21260	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-7				TCAGCCGTGCCAGCACTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50909904746341528					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610848	181610898	181893060	181893110	21261	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-8				GGGGGTTCTGGGCAAACACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0031863116392986781					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181610691	181610741	181892903	181892953	21262	hg38	N/A	enh7705	N/A	Enhatls129689	enhancer	SOX2e-8-9				TTTATCTGCAGGTAGCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19632837605320819					SOX2	chr3	181711924	181714436	178342				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661084	181661134	181943296	181943346	21263	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-1				GTCGCTAAAGTAAACAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.094148914874850845					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661040	181661090	181943252	181943302	21264	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-10				GTTGAATGTAGGTATCTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0019373485616618359					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661495	181661545	181943707	181943757	21265	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-11				TGATTGGTGACTTTTAAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29845261239258669					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661019	181661069	181943231	181943281	21266	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-12				ACCATTAGCACATGTCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48558982529741029					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661479	181661529	181943691	181943741	21267	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-13				ACAAAACAGATCCAGTTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.206602447037716					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661448	181661498	181943660	181943710	21268	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-14				GTGCTGAGCAAAATGTGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0955302271587229					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661211	181661261	181943423	181943473	21269	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-15				TGTTGCAGGTAGAACCACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.02840579650776					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661331	181661381	181943543	181943593	21270	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-16				CCAAAAAAACTGCTCTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.67694240741742562					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661279	181661329	181943491	181943541	21271	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-17				GACTTCATCCTGGCTTCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37592951700816551					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181660971	181661021	181943183	181943233	21272	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-18				AGTGTGGCTTCTTCCAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.185012902846932					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181660984	181661034	181943196	181943246	21273	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-19				TAAAACAAATAGTCCCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.048191781628218661					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661188	181661238	181943400	181943450	21274	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-2				GCTTAAAGGGGTATCCCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.08847926560234709					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661342	181661392	181943554	181943604	21275	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-20				GCTCTCCTTTGGAAAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.96448501610344739					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661255	181661305	181943467	181943517	21276	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-21				CGAACAATGAGGAGGGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.91373527311790581					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661070	181661120	181943282	181943332	21277	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-22				CAGCAGGGGAGAGGCACGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.39560183523807341					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661411	181661461	181943623	181943673	21278	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-23				GATGCTAATTTTTCATTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.56579228291697126					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661225	181661275	181943437	181943487	21279	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-24				CTTTCCTGCCCTCACCTCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23053155367483111					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661530	181661580	181943742	181943792	21280	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-25				TTTTAAAAACACATTAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33023464382065532					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661138	181661188	181943350	181943400	21281	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-3				CATGCTCTAAGACCCTAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2871442759737235					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661173	181661223	181943385	181943435	21282	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-4				GACTTCAAAAAACAGCCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0348516533312665					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661200	181661250	181943412	181943462	21283	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-5				CTACCTGCAACAGCTTAAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.043158546737562677					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661244	181661294	181943456	181943506	21284	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-6				AAAGCTTCAAGCGAACAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.079995777527951117					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661435	181661485	181943647	181943697	21285	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-7				TGTGATTTGGATGGAATGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21867378402328019					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661297	181661347	181943509	181943559	21286	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-8				CTAATTGTTTCAGGGCACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.057943682193372863					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-121200	chr3	181661125	181661175	181943337	181943387	21287	hg38	N/A	enh71022	N/A	Enhatls129689	enhancer	SOX2e-9-9				TGATACCACAAAGCCTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.195290465577497					SOX2	chr3	181711924	181714436	224396				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9329
enhrx-lit609	chr3	181428265	181428315	181710477	181710527	21288	hg38					enhancer	SOX2e+1-1				GCAGCACGTCCGTTACAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39471589861851591													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit610	chr3	181428559	181428609	181710771	181710821	21289	hg38					enhancer	SOX2e+1-10				CTTGCGCGGCCTGGGCTTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.36939047737965142													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit611	chr3	181428361	181428411	181710573	181710623	21290	hg38					enhancer	SOX2e+1-11				TTGCCCGCCCAGGACCCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40100338081040182													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit612	chr3	181428234	181428284	181710446	181710496	21291	hg38					enhancer	SOX2e+1-12				TTTCTCTTGTTGTCGCTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32995825676648438													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit613	chr3	181428328	181428378	181710540	181710590	21292	hg38					enhancer	SOX2e+1-13				ACGTCGGGACAATGGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25426176215205459													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit614	chr3	181428571	181428621	181710783	181710833	21293	hg38					enhancer	SOX2e+1-14				GGGCTTTGCGGCCACCACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.006325285689588696													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit615	chr3	181428418	181428468	181710630	181710680	21294	hg38					enhancer	SOX2e+1-15				AGCAAGGCCCGGGTTAGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1212236321951181													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit616	chr3	181428594	181428644	181710806	181710856	21295	hg38					enhancer	SOX2e+1-16				AAATCTACGGGGAAAATGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.585235038690909													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit617	chr3	181428474	181428524	181710686	181710736	21296	hg38					enhancer	SOX2e+1-17				AGGTGCAGGCAGCGCACACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.012579279729713219													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit618	chr3	181428672	181428722	181710884	181710934	21297	hg38					enhancer	SOX2e+1-18				ACTGTATGGAGGTGGCTTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88603790616190736													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit619	chr3	181428706	181428756	181710918	181710968	21298	hg38					enhancer	SOX2e+1-19				GGAGGGTGATTTCAACTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.069273548370624882													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit620	chr3	181428294	181428344	181710506	181710556	21299	hg38					enhancer	SOX2e+1-2				TAGGTAGGCGCTCAATGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0040213344183723694													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit621	chr3	181428453	181428503	181710665	181710715	21300	hg38					enhancer	SOX2e+1-20				GGAGAAGGCGGCCGGGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38882581227808111													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit622	chr3	181428608	181428658	181710820	181710870	21301	hg38					enhancer	SOX2e+1-21				AATGCCAGGGCTGGTTCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30851481607045578													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit623	chr3	181428488	181428538	181710700	181710750	21302	hg38					enhancer	SOX2e+1-22				TGCTCTCCAGGCACAGGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.21822732381175231													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit624	chr3	181428649	181428699	181710861	181710911	21303	hg38					enhancer	SOX2e+1-23				TGGGAGGGAGTTTGTGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1272673425988318													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit625	chr3	181428545	181428595	181710757	181710807	21304	hg38					enhancer	SOX2e+1-24				GGCGCAGCCCCAGCCTTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.058857707570074191													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit626	chr3	181428515	181428565	181710727	181710777	21305	hg38					enhancer	SOX2e+1-25				GGCTCAAGGCCTGGGAGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.83583208808919													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit627	chr3	181428407	181428457	181710619	181710669	21306	hg38					enhancer	SOX2e+1-26				GGTTAGAGGAGGATGAGATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19898450116965849													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit628	chr3	181428429	181428479	181710641	181710691	21307	hg38					enhancer	SOX2e+1-27				AGGGGGAGCCCAGCAAGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.69197689722777767													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit629	chr3	181428442	181428492	181710654	181710704	21308	hg38					enhancer	SOX2e+1-28				GGCTCCCCCTTCCCCAGTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0639040459091247													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit630	chr3	181428395	181428445	181710607	181710657	21309	hg38					enhancer	SOX2e+1-29				ATGAGATGGGGGCGGGGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35471691059910321													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit631	chr3	181428583	181428633	181710795	181710845	21310	hg38					enhancer	SOX2e+1-3				CACCACAATGGAAATCTACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17478018304532911													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit632	chr3	181428629	181428679	181710841	181710891	21311	hg38					enhancer	SOX2e+1-4				GGAGTCCTGGGAACTCTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39781070328533469													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit633	chr3	181428347	181428397	181710559	181710609	21312	hg38					enhancer	SOX2e+1-5				GCGGCTAAAATTACCCTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.30470237473497908													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit634	chr3	181428500	181428550	181710712	181710762	21313	hg38					enhancer	SOX2e+1-6				AGGCGGGGTCGATGCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.22437069588262429													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit635	chr3	181428313	181428363	181710525	181710575	21314	hg38					enhancer	SOX2e+1-7				CCTATTGAAATCTTTACGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42503708306331389													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit636	chr3	181428683	181428733	181710895	181710945	21315	hg38					enhancer	SOX2e+1-8				CATCCCACGGCACTGTATGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.1169972359442588													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit637	chr3	181428529	181428579	181710741	181710791	21316	hg38					enhancer	SOX2e+1-9				CTGCGCCGCAAAGGGGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.54119079453170382													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-121120	chr3	179853857	179853907	180136069	180136119	21317	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-1				GAACATTGGTTCAGTCCGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18040667444963751					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853815	179853865	180136027	180136077	21318	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-10				GAGGCTTCCAGGTCACAGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0512512308379081					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853665	179853715	180135877	180135927	21319	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-11				CTAAAAGGAAAATTCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1177808221682113					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853732	179853782	180135944	180135994	21320	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-12				AGATTTATCTCAGTGAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44332610606514278					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853763	179853813	180135975	180136025	21321	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-13				TTTCTGATTAGCCTTTACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.26547055090863758					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853801	179853851	180136013	180136063	21322	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-14				ACAGGTAGGTGAGAGACAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.124223573398845					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853930	179853980	180136142	180136192	21323	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-15				AGCTGTGCTCTGACCACCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95612046286582486					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853911	179853961	180136123	180136173	21324	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-16				AGCTTGATTTTATACATTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.941450622825907					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853650	179853700	180135862	180135912	21325	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-17				CCCAAAATCACTAAGCTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2816345108577058					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853788	179853838	180136000	180136050	21326	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-2				AGACAAAAGGTTGCATTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.067093331073666052					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853826	179853876	180136038	180136088	21327	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-3				CTTGAAGGGAGGAGGCTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65871855781439437					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853841	179853891	180136053	180136103	21328	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-4				CGGAAGGCAGGACAACTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14356608305419649					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853615	179853665	180135827	180135877	21329	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-5				TTTTCTTTCACAACAGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33391865123649411					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853877	179853927	180136089	180136139	21330	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-6				TTCATTTCACATATATTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.4482859278077118					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853711	179853761	180135923	180135973	21331	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-7				GGGATGACTTTCAACAGAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.61430486028021691					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853677	179853727	180135889	180135939	21332	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-8				TTCAAGCTGGGAGCTGCTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27165395573194839					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853752	179853802	180135964	180136014	21333	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+10-9				TCTGATTGCGTCCTTTGTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.78269089467000363					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852858	179852908	180135070	180135120	21334	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-1				CACAAAATTGTGGACTATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22136614591712031					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852998	179853048	180135210	180135260	21335	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-10				TAGGGCACTTTGACATGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052872243596983858					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853041	179853091	180135253	180135303	21336	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-11				AGCCTCAGAATCAGGCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24112969540298321					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853306	179853356	180135518	180135568	21337	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-12				ATTATGTTTGGGGTGAGAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.3338007476261211					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853258	179853308	180135470	180135520	21338	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-13				ACAAATTTTATCTGGGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.095516152225177522					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853372	179853422	180135584	180135634	21339	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-14				GGTAAAATATCCTCTTCATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.67069486459075067					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853159	179853209	180135371	180135421	21340	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-15				CCAGAAGAAATGCAGTTTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.083572065821647251					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853101	179853151	180135313	180135363	21341	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-16				GAAAGTTTCTTCCTGTGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.182722031985037					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852979	179853029	180135191	180135241	21342	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-17				AGAAAATGATATGCCAGAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.44346822801278007					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853070	179853120	180135282	180135332	21343	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-18				GAGGGGTGAGAGACGGATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34693305639968591					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853318	179853368	180135530	180135580	21344	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-19				AAGGAAGAGTAAATTATGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.9558139671358852					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852902	179852952	180135114	180135164	21345	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-2				GTACCTTCTACATCCAACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.16132214465165359					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853337	179853387	180135549	180135599	21346	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-20				GGGGTTGTAGGCAATTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2385862337217875					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853087	179853137	180135299	180135349	21347	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-21				GTGCTTTGGGAGAGGTAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.66363597047382239					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853349	179853399	180135561	180135611	21348	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-22				GAGAGGGAAGTAGGGGTTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29659532065194572					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853283	179853333	180135495	180135545	21349	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-23				CAGGCTATTGTCTGTTCTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02647115402248075					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853240	179853290	180135452	180135502	21350	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-24				ATTACAGTTGACACCACACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-3.4839822035200552					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852889	179852939	180135101	180135151	21351	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-3				AGACTGATCCACTCCACAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.039775364045612688					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852951	179853001	180135163	180135213	21352	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-4				AGCACCTATCTCACCCCTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0053749163816245128					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853134	179853184	180135346	180135396	21353	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-5				GAACCTCCTTCAGTCAGGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27219410490678791					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853213	179853263	180135425	180135475	21354	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-6				ATAGAACATTAACTCGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.71704291527260056					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853385	179853435	180135597	180135647	21355	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-7				ATATTTTACCTTCAATCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45430687216281812					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179853187	179853237	180135399	180135449	21356	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-8				TGATGAGATTATATATAGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0486509517589825					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121120	chr3	179852964	179853014	180135176	180135226	21357	hg38	N/A	enh71013	N/A	Enhatls129608	enhancer	SOX2e+11-9				CATTTTCTAAGCTCCAGCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.168152438477097					PEX5L	chr3	179794957	180037053	96515				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9249
enhrx-121116	chr3	179660142	179660192	179942354	179942404	21358	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-1				CACGCCAGAACAGCCGCGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3999485476915533					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660235	179660285	179942447	179942497	21359	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-10				CGCGCAGCGGGCGCGGTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29300940184372681					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660426	179660476	179942638	179942688	21360	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-11				CCTTCACTGGGACGCACACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.052854148062489559					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660358	179660408	179942570	179942620	21361	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-12				AGAGGGAATCCGGGTGCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.670034959200123					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660247	179660297	179942459	179942509	21362	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-13				GCCTTGGGCATGCGCGCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34305905372031931					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660269	179660319	179942481	179942531	21363	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-14				ACTGCCCTGCAGAAGCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22045747903704191					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660269	179660319	179942481	179942531	21364	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-14				ACTGCCCTGCAGAAGCGCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22045747903704191					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660182	179660232	179942394	179942444	21365	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-15				CCAGAGCAATGACAACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47120187113217887					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660087	179660137	179942299	179942349	21366	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-16				GTTTTGGAGCACTTTGCACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.270308543540338					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660057	179660107	179942269	179942319	21367	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-17				CAGAAATAGCAGCCACGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.026344365947641481					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660020	179660070	179942232	179942282	21368	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-18				AAATGAGGCCCAGGCTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0097551426456333					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660397	179660447	179942609	179942659	21369	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-19				GAGACGGATGGTTTCTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.12519270460598739					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660129	179660179	179942341	179942391	21370	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-2				CGAACCCGATGTCCCTCTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3133987217187314					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660442	179660492	179942654	179942704	21371	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-20				CACATGGAAGACAGTGGACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.51758594286928372					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660099	179660149	179942311	179942361	21372	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-21				TTTGCACCTGGAGCCTGAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.090017516134934583					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660206	179660256	179942418	179942468	21373	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-22				ACCGCGGAGGCGGCTGGGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40466342537162708					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660413	179660463	179942625	179942675	21374	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-23				TCCCAGGACTCTGCCTTCAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.155519731372416					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660324	179660374	179942536	179942586	21375	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-24				GACCAAAGAATTCAAGATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.77872363900552366					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660004	179660054	179942216	179942266	21376	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-25				TCTTGGGAGAAGATGCAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.38356653794406942					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660071	179660121	179942283	179942333	21377	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-26				CTATTTCTGCTGCTTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1043736783716249					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660346	179660396	179942558	179942608	21378	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-27				GGTGCAGTGGGAGGGAGGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.4717672261769581					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660381	179660431	179942593	179942643	21379	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-3				CTCGACCCAGGCGCATGAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.23097985416384559					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660291	179660341	179942503	179942553	21380	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-4				TGGCACCGGTAGGCACTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34378630476291561					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660291	179660341	179942503	179942553	21381	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-4				TGGCACCGGTAGGCACTCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.34378630476291561					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660112	179660162	179942324	179942374	21382	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-5				GGTTCGGAGTGGCCCTCCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21884864174225671					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660193	179660243	179942405	179942455	21383	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-6				ACAACACTGCGGGACCGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62725933585168636					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660369	179660419	179942581	179942631	21384	hg38	N/A	N/A	N/A	Enhatls129605	enhancer	SOX2e+12-7				CGGATTCCCTCTCTCGACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.348078863002129					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660045	179660095	179942257	179942307	21385	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-8				CCTCCGAGGGCTCCTTTTCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.25154744389786171					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121116	chr3	179660032	179660082	179942244	179942294	21386	hg38	N/A	N/A	fant14361	Enhatls129605	enhancer	SOX2e+12-9				GGGCCTCATTTCTCCTCCGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1755433942822387					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9245
enhrx-121110	chr3	179600304	179600354	179882516	179882566	21387	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-1				CGAATGGCCAGCTTTGAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2449814956908343					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600274	179600324	179882486	179882536	21388	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-10				AGCCACCTCCTTCATCAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0070612174752042274					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600518	179600568	179882730	179882780	21389	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-11				GCCTGAAGGATCTTTAAAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70415770795174981					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600248	179600298	179882460	179882510	21390	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-12				GCACACACAGAAAGCCTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.60596908938156857					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600424	179600474	179882636	179882686	21391	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-13				TACTTTTAAATCTTAGCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	6.18343600417086					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600226	179600276	179882438	179882488	21392	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-14				GCAAATGTGAAACAAATGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.2271050714044108					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600183	179600233	179882395	179882445	21393	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-15				AAAGAGCTCAGAACAAATAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38906489562135282					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600344	179600394	179882556	179882606	21394	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-16				ACGTTTTCAAAAGGAGAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41560260993466419					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600172	179600222	179882384	179882434	21395	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-17				AACAAATACAGGAATTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55059352629280456					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600209	179600259	179882421	179882471	21396	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-18				ATTTGCAAGAAAAAGAACAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21101684070423149					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600262	179600312	179882474	179882524	21397	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-2				CATCAGCTGGGTAACCAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.040805720104295222					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600368	179600418	179882580	179882630	21398	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-3				GGGTGTAGCCTTTCACTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.73601128789922865					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600333	179600383	179882545	179882595	21399	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-4				TTTTGAAAACGTACTCTGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44424479937375372					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600470	179600520	179882682	179882732	21400	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-5				GACAGCCCTGGTATGGTAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.01071086501011337					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600160	179600210	179882372	179882422	21401	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-6				AATTGCCCAGGACACTTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.32574233588365381					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600128	179600178	179882340	179882390	21402	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-7				AATTCAAACTTGGCTCAGTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.212265041461845					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600458	179600508	179882670	179882720	21403	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-8				GCTCCACACAAAGACAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.27825970932305411					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121110	chr3	179600288	179600338	179882500	179882550	21404	hg38	N/A	enh71009	N/A	Enhatls129599	enhancer	SOX2e+13-9				GAGGTGGCTTGGAGGTCGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.52363755647681409					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9239
enhrx-121108	chr3	179586567	179586617	179868779	179868829	21405	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-1				GTTGCAGGATGCGTTATGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.19337376571629539					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586618	179586668	179868830	179868880	21406	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-10				TGAGGTTGTGGAGAGAATAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42301392651159753					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586480	179586530	179868692	179868742	21407	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-11				GGAGTCTCAGAGAGAATAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23198018259551911					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586402	179586452	179868614	179868664	21408	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-12				GATCTGGGCAAAGGAAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25941871291181817					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586202	179586252	179868414	179868464	21409	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-13				TTCTAAAGGAGTAATGTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-5.7363339175435577					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586630	179586680	179868842	179868892	21410	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-14				TATATACCATCTTGAGGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.71783681853010128					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586537	179586587	179868749	179868799	21411	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-15				GAAGAGGCTTGGCTAGCAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.32562282601973142					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586448	179586498	179868660	179868710	21412	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-16				GACACCTTTAAAGGACTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.47406128997365832					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586658	179586708	179868870	179868920	21413	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-17				CTGTACCTCACTGGGGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.29343891526981					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586216	179586266	179868428	179868478	21414	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-18				TATGTTTTCTAAATTTCTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29166643811515808					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586417	179586467	179868629	179868679	21415	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-19				AGTTAATCTTTCCTAGATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33870289714453738					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586672	179586722	179868884	179868934	21416	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-2				GGGGTTGGGTCTTCGTTCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22215139532518791					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586553	179586603	179868765	179868815	21417	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-20				TATGGGAGGGAGAAAGGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-7.3287970697243541					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586310	179586360	179868522	179868572	21418	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-21				TTCTTTGACATAATCTGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.073571107262087237					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586336	179586386	179868548	179868598	21419	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-22				TGCAAAGCTGTCTTTTGTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.82523716214296794					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586299	179586349	179868511	179868561	21420	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-23				TATGTCAAAGAAATATATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.26525350871806					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586689	179586739	179868901	179868951	21421	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-3				CGTGTATACACAGGAGCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17802071278608761					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586239	179586289	179868451	179868501	21422	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-4				GCAATTTAAACCTTAAGTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.07191003466049567					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586505	179586555	179868717	179868767	21423	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-5				ATATAGATGAAGCCTCTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33670789183755279					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586582	179586632	179868794	179868844	21424	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-6				CAAAAACAGGTTTTGGTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84198188680349706					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586493	179586543	179868705	179868755	21425	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-7				CTGAGACTCCTACCTGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.8100499257299254					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586605	179586655	179868817	179868867	21426	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-8				AGAATATGGGCTCAGAGCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29458651065556851					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179586258	179586308	179868470	179868520	21427	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+14-9				TTGCTCTGGTTTGGGATTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37719139790120909					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179584004	179584054	179866216	179866266	21428	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-1				GCTATTAACAACGGTCATTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0828057822175295					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583822	179583872	179866034	179866084	21429	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-10				GTTTAACTTAATTGGATTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.80051711356660316					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583800	179583850	179866012	179866062	21430	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-11				TTTACAAATGGCATTTTAAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0850637245853843					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583934	179583984	179866146	179866196	21431	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-12				GGATTTAACAGATTTTTAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14528313247905189					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583740	179583790	179865952	179866002	21432	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-13				CATTTTTCAAAATCATGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1689989933306966					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583765	179583815	179865977	179866027	21433	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-14				CCACAGCTATAGCAAGCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45086560095752548					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583913	179583963	179866125	179866175	21434	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-15				TAGGTAAAGAGAGAGAAGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.2238268173404112					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583993	179584043	179866205	179866255	21435	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-2				CGGTCATTGTGGTTAGCCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.01067963088522993					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583977	179584027	179866189	179866239	21436	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-3				TTGTTCTAGCAAAACTCCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41371491866311938					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583783	179583833	179865995	179866045	21437	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-4				TGTAAACCCAAGATGTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.033203699650025731					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583679	179583729	179865891	179865941	21438	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-5				TATATAGTTCACAAATGTAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.8093319728379891					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583880	179583930	179866092	179866142	21439	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-6				TTCAGAACAATCAACAGTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65471485119604289					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583705	179583755	179865917	179865967	21440	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-7				TCACAAATGTACTCTAATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25178632273596918					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583857	179583907	179866069	179866119	21441	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-8				GAACTTAATGCTTTCTTCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.072487994536208					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121108	chr3	179583894	179583944	179866106	179866156	21442	hg38	N/A	enh113426	N/A	Enhatls129596	enhancer	SOX2e+15-9				TGTTCTGAATGATAAGCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46131320221370259					PEX5L	chr3	179794957	180037053	0				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9237
enhrx-121197	chr3	181422673	181422723	181704885	181704935	21443	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-1				GCAGCAACCCACGTAGCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5322305706768804					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422618	181422668	181704830	181704880	21444	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-10				TTATCTGCCCGTCTGAGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.024158184939594041					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422967	181423017	181705179	181705229	21445	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-11				CAATGGAATTCTCAGATCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.42447779176669481					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422660	181422710	181704872	181704922	21446	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-12				TAGCCGCTGGGCCCTGGATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.0823992880719708					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422340	181422390	181704552	181704602	21447	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-13				ACACCTTTCATGATGAACCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.050019278506669762					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422708	181422758	181704920	181704970	21448	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-14				ATGGTGTCAAGTTGTACTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.46958112407293751					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422539	181422589	181704751	181704801	21449	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-15				TGGCGCCTTTGTCTGTGTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40459353197067738					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422819	181422869	181705031	181705081	21450	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-16				TTGAAGATCATTGACACGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41638293870012982					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423062	181423112	181705274	181705324	21451	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-17				TGAGAAGTCGGCCTTCCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.64622056979310216					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422649	181422699	181704861	181704911	21452	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-18				AGACTGGGGGTCCTAATCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.14504441206306259					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422719	181422769	181704931	181704981	21453	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-19				ACTTGACACCATTGAGCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0803037343284731					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422735	181422785	181704947	181704997	21454	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-2				AGATTATTGACAAGCACCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1000733802600077					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422933	181422983	181705145	181705195	21455	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-20				TTAAAGGCTCCTTCGGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34039323389794968					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422358	181422408	181704570	181704620	21456	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-21				TCAGAGTTCGGGTTCTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0990023149541356					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422979	181423029	181705191	181705241	21457	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-22				GAATTCCATTGGGATGGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.855959526928669					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422834	181422884	181705046	181705096	21458	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-23				ATCTTCAAATTAAGGAGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.385852374168046					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422302	181422352	181704514	181704564	21459	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-24				AAAGGGTCTGAGGAGTTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70841948336940574					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423047	181423097	181705259	181705309	21460	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-25				GCAAGCAGAAGTGGGCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.066090477371858872					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423003	181423053	181705215	181705265	21461	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-26				AACCCAACTCCATCTGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1409126382549819					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422785	181422835	181704997	181705047	21462	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-27				TAGATCATAACAGTTTCTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.79741980176535265					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422374	181422424	181704586	181704636	21463	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-28				ACTCTGAAAAACAGTACATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.42508475471856638					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422559	181422609	181704771	181704821	21464	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-29				GCCCGCCTGGGCTTTCTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70711625897950059					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422268	181422318	181704480	181704530	21465	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-3				CGGATGGGCCCACTTAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.544654562071323					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422406	181422456	181704618	181704668	21466	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-30				TGATAGTTATTTGGGTGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31274522783604292					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422291	181422341	181704503	181704553	21467	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-31				GGAGTTGGCAGGGTCTCAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.080508760182213993					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422887	181422937	181705099	181705149	21468	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-32				CACCCTTCTTCCCTTTTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.137743394920945					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423023	181423073	181705235	181705285	21469	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-33				AGGACTGGAAGAGGGGCGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56923024744525319					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422491	181422541	181704703	181704753	21470	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-34				TTCACTCTGTTTTCAAACTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30278847723329583					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422440	181422490	181704652	181704702	21471	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-35				TTAATAAAGACTAAGATTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	3.0553934739509532					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423082	181423132	181705294	181705344	21472	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-36				TCAGGCATTTCTTTTGAGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35518720762742889					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422876	181422926	181705088	181705138	21473	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-37				AGTGGGGAGAGCCAGCAAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.87926020110097913					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422328	181422378	181704540	181704590	21474	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-38				ATGAAAGGTGTGAGGGATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.28565304381362422					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422572	181422622	181704784	181704834	21475	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-4				TCAACTGCTTCAAGCCCGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1868125678059285					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422253	181422303	181704465	181704515	21476	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-5				TGAGGACTATCCAGGCGGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.65728939674495146					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422949	181422999	181705161	181705211	21477	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-6				GCTGGCCTGATAATCTTTAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.2514063106683639					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422635	181422685	181704847	181704897	21478	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-7				AGATAAGCACTGCCAGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.03399183945070227					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181423094	181423144	181705306	181705356	21479	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-8				TTTGAGGCCGGAATAGCTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0697662375418321					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181422860	181422910	181705072	181705122	21480	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+2-9				GGCGAGACGAAAAAGGAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18517455103767569					SOX2	chr3	181711924	181714436	5003				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181417640	181417690	181699852	181699902	21481	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+3-1				TACAAGACAACACCCTGATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24072397741492149					SOX2	chr3	181711924	181714436	11568				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121197	chr3	181417652	181417702	181699864	181699914	21482	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+3-10				TACATGTCCATGCCAGATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1286397776036822					SOX2	chr3	181711924	181714436	11568				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-lit638	chr3	181417501	181417551	181699713	181699763	21483	hg38					enhancer	SOX2e+3-11				TGCCTTGGATGAAGGACGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.50979214734726208													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit639	chr3	181417600	181417650	181699812	181699862	21484	hg38					enhancer	SOX2e+3-12				TAAAAAAGCGAAAGAACGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.90952353318307755													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-121197	chr3	181417623	181417673	181699835	181699885	21485	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+3-13				CTTGTAGCAGTTTGATTGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.19636880403006091					SOX2	chr3	181711924	181714436	11568				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-lit640	chr3	181417433	181417483	181699645	181699695	21486	hg38					enhancer	SOX2e+3-14				GCGATGTGGGTGAAGGCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.29145532807775337													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit641	chr3	181417453	181417503	181699665	181699715	21487	hg38					enhancer	SOX2e+3-15				AGGCTGATGGAAAGACTGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0096685519378661277													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit642	chr3	181417386	181417436	181699598	181699648	21488	hg38					enhancer	SOX2e+3-16				GGGATTGCAGTGGCAAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34238459500012958													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit643	chr3	181417470	181417520	181699682	181699732	21489	hg38					enhancer	SOX2e+3-17				GGGGGGAAGAAAAGCCGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.625192525090036													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit644	chr3	181417525	181417575	181699737	181699787	21490	hg38					enhancer	SOX2e+3-2				GAACTGCAAGCTCCTTCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.020849527635096													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit645	chr3	181417420	181417470	181699632	181699682	21491	hg38					enhancer	SOX2e+3-3				AGGCTGGTGTAAGGCGATGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37494489724402708													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit646	chr3	181417484	181417534	181699696	181699746	21492	hg38					enhancer	SOX2e+3-4				AAGGCACCGTGAATCCATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0742416639796918													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit647	chr3	181417567	181417617	181699779	181699829	21493	hg38					enhancer	SOX2e+3-5				ATCAAGCTTGGGCTGACAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.79035492934926377													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit648	chr3	181417400	181417450	181699612	181699662	21494	hg38					enhancer	SOX2e+3-6				AAAGCTAGGCTAGGTCTTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.49097293685835119													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit649	chr3	181417555	181417605	181699767	181699817	21495	hg38					enhancer	SOX2e+3-7				CGGTGAGAAGTGATCAAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48955836158818489													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-lit650	chr3	181417537	181417587	181699749	181699799	21496	hg38					enhancer	SOX2e+3-8				CACCGGACAGAACCAGTTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.166119929328454													CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	
enhrx-121197	chr3	181417688	181417738	181699900	181699950	21497	hg38	N/A	N/A	N/A	Enhatls129686	enhancer	SOX2e+3-9				CTAGCAGTGAATGTCAAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54966280156233716					SOX2	chr3	181711924	181714436	11568				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9326
enhrx-121196	chr3	181413220	181413270	181695432	181695482	21498	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-1				GCCAGTACCGCTCCGAGGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.298004323343009					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412915	181412965	181695127	181695177	21499	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-10				AACCGAGATTGGGCCAGCAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.1155338426531209					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413469	181413519	181695681	181695731	21500	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-11				TGGAAACCCGAGGAGAAACG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	2.6235638449911081					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412779	181412829	181694991	181695041	21501	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-12				GGCCATGCTGGCTAGGTACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.080996018227400254					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413068	181413118	181695280	181695330	21502	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-13				TTGGAACCGTCTGTTTTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39960032843082849					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413294	181413344	181695506	181695556	21503	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-14				GGCCGGACGCGCACGGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.374343027345637					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413523	181413573	181695735	181695785	21504	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-15				GGCTGACAAGTTTATTCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.108766062806762					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413272	181413322	181695484	181695534	21505	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-16				CCCGAGCCGCGCTAGGCCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.34554241854491091					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413128	181413178	181695340	181695390	21506	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-17				TTGGCCGCCCGCCTGCGCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.064277387046955417					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413414	181413464	181695626	181695676	21507	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-18				ACAAGGCCGACCCACCCAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1180186469694991					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412882	181412932	181695094	181695144	21508	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-19				GAGAGCCGCTCTCTTCTGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48697823354813241					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413033	181413083	181695245	181695295	21509	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-2				GTGCGGGGAACGAACCCAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.82795343823423451					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412964	181413014	181695176	181695226	21510	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-20				GATCGTGGTTCCCTGGAGAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.24313882809537979					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412850	181412900	181695062	181695112	21511	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-21				GCCACGGACCTGGAAACCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1993890731109717					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413502	181413552	181695714	181695764	21512	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-22				AAAGGACAGAGGCGGCGAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41147317610298922					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413249	181413299	181695461	181695511	21513	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-23				CGCGGCCCTGGCTCCGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.597111220349698					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412994	181413044	181695206	181695256	21514	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-24				CGAGCCCAGGAGAACCTCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15374255453893179					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413099	181413149	181695311	181695361	21515	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-25				GCTGACTCTAGACTCAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.068049616801997156					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413331	181413381	181695543	181695593	21516	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-26				CGGGTGGTGGCGCAGTTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3297401761937146					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412821	181412871	181695033	181695083	21517	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-27				AGGTGACAGTGCAGGCTCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0524166389839089					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412926	181412976	181695138	181695188	21518	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-28				GGAAAGTCAGGAACCGAGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.027650674818351741					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413047	181413097	181695259	181695309	21519	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-29				GGTGCACAGTGTGTCCAGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15694167954494859					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413007	181413057	181695219	181695269	21520	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-3				GTGGGCGAAACGGCGAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.23632670101980141					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412675	181412725	181694887	181694937	21521	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-30				TAGAGAAGGATGTAACTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1105393622420129					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412701	181412751	181694913	181694963	21522	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-31				ATGCTCTGGGACCTGACAAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.108938359966797					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412664	181412714	181694876	181694926	21523	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-32				GTAACTAAGTGGAAATTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.5623548136137525					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412938	181412988	181695150	181695200	21524	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-33				GGGTTCGGGGGTGGAAAGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.74477458041390676					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413307	181413357	181695519	181695569	21525	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-34				CGGAAGGGGGCTGGCGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.54246962675493049					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412715	181412765	181694927	181694977	21526	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-35				CCAGAGCATAAAACAGACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20465578853296509					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413318	181413368	181695530	181695580	21527	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-36				TGGCGGACACGGCCGGGTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.2627716513856659					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413139	181413189	181695351	181695401	21528	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-37				CGTGGGCTGCTCCGAGGCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.40341829875126772					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413087	181413137	181695299	181695349	21529	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-38				CTCAAATGCGGAAATGAATT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.3597696836946902					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412953	181413003	181695165	181695215	21530	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-39				CCGAACCCTCCCCGCTCTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.73355742798658174					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413018	181413068	181695230	181695280	21531	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-4				CGTTTCGCCCACGGGGTGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17609728907774541					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413484	181413534	181695696	181695746	21532	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-40				GGTTTCCACAGACCCAGGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.38642513240031873					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412751	181412801	181694963	181695013	21533	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-41				TCTCACCCTTCTCACACTTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063653549767160922					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412979	181413029	181695191	181695241	21534	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-42				CTCTCTGGAGGGCTGGATCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3294104538611462					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413167	181413217	181695379	181695429	21535	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-43				GTGAAGGCGCGTGGGGAAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.1835742333507189					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413445	181413495	181695657	181695707	21536	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-44				CTGAGGCTGAAAGTGTCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2993749732412252					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412690	181412740	181694902	181694952	21537	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-45				CTTCTCTAGTCCCTGTTGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.040568771737150927					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413385	181413435	181695597	181695647	21538	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-46				TCGCTGGAGTGGGGAAGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	1.88778411739446					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412902	181412952	181695114	181695164	21539	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-47				AGGGTCTCCCAGTCCCTTGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.13803454661061521					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413538	181413588	181695750	181695800	21540	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-48				TCTAGAGGCTTTGAAAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.610264595066331					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413183	181413233	181695395	181695445	21541	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-49				AAGGGGGGCCTGGAAAGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.33725632683983142					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413397	181413447	181695609	181695659	21542	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-5				CACTCCAGCGAAACTGGACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.05335016429023666					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413236	181413286	181695448	181695498	21543	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-50				GGAGGGGCCTCAGCCTCCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.86856832610847545					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413371	181413421	181695583	181695633	21544	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-51				AAGCGGAGGCGCGGGCCGGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1592709818089581					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412834	181412884	181695046	181695096	21545	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-52				ACTGTCACCTTCCCCACCTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16450578059044341					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412653	181412703	181694865	181694915	21546	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-53				GAAATTTAGAGGTAGAAGCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.88527251636254711					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412866	181412916	181695078	181695128	21547	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-54				GGCTCTCAGGTCAGGAGCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84704248344206956					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412767	181412817	181694979	181695029	21548	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-55				GGTGAGAAGGCAGGCCATGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.31186611927792951					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413356	181413406	181695568	181695618	21549	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-56				CACAGGGCAGCCCAGCCCGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55709775611443413					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413261	181413311	181695473	181695523	21550	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-57				GCGCGGCTCGGGCGCGGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.56988206772367656					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413201	181413251	181695413	181695463	21551	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-6				TGGCCGAGTGAGTCGAAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.023908671948282					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413156	181413206	181695368	181695418	21552	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-7				ACGCGCCTTCACGGGCTCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.063614227884311272					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181412802	181412852	181695014	181695064	21553	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-8				CTGGCGGCCTGTCTGCTAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.37474423140215268					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121196	chr3	181413433	181413483	181695645	181695695	21554	hg38	N/A	enh100128	N/A	Enhatls129685	enhancer	SOX2e+4-9				GTGTCTTGAGGGATCGGGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.224849822921443					SOX2	chr3	181711924	181714436	15682				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9325
enhrx-121189	chr3	181102725	181102775	181384937	181384987	21555	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-1				TAACTCAGTGTAGCACATGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.0874860179879768					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102850	181102900	181385062	181385112	21556	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-10				CTGCAACAGCATGGGGAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25060735664452838					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102663	181102713	181384875	181384925	21557	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-11				TGGAAGGGCTTCTGTAGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.04918316903548392					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102918	181102968	181385130	181385180	21558	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-12				CACATGTGCTGATGTCCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.092747466848308					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102954	181103004	181385166	181385216	21559	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-13				CTTGAGAAATGCTTACACAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.15599392412382879					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102903	181102953	181385115	181385165	21560	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-14				ATGTGACTTGCTTGGCCACT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33989149807899671					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102868	181102918	181385080	181385130	21561	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-15				TGCAGTTCCCTCCCACACTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.48787655438231309					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102879	181102929	181385091	181385141	21562	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-16				GCCAAGCTCAGCCTCAGTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.018290415562998621					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102931	181102981	181385143	181385193	21563	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-17				AGCACATGTGACACAATCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.062829390932717138					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102984	181103034	181385196	181385246	21564	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-2				GGTGCCAACAGAGTTTCAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.054631188539728412					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102676	181102726	181384888	181384938	21565	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-3				AGCCCTTCCAGTTATTCTTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.106350845490111					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181103023	181103073	181385235	181385285	21566	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-4				ATATTCATGGAGGCTGGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.568912312780682					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102739	181102789	181384951	181385001	21567	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-5				ACATGAGGGCTGCAGCTATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.21692963080731109					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102793	181102843	181385005	181385055	21568	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-6				ATCTCTTACAGTTACAATTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.007733875822173					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181103005	181103055	181385217	181385267	21569	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-7				CCATGTGAAGAAGTGCAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059775060138972207					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181102833	181102883	181385045	181385095	21570	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-8				GCCTGGAAGGTGTGATTCAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.24911980610118281					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181103036	181103086	181385248	181385298	21571	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+5-9				TCTCTTTAAGAGCATATTCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-4.91411143968782					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101647	181101697	181383859	181383909	21572	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-1				GATACTTTTGGCTACTCCTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.18941264393238849					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101537	181101587	181383749	181383799	21573	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-10				GATTTGTTTGGGTGTAATCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3810273916823968					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101934	181101984	181384146	181384196	21574	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-11				TAGCAAGTCAAGAAAGTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12457056461182089					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101716	181101766	181383928	181383978	21575	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-12				GGAAATTAGTTAAGTGTGAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-1.0340048592989459					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101581	181101631	181383793	181383843	21576	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-13				TTCTTCAATATTCCAAACCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1077915448624765					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101915	181101965	181384127	181384177	21577	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-14				TTGGTATGATGCAGAGAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.044615323525636658					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101526	181101576	181383738	181383788	21578	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-15				TAGATTTGAGAGATTTGTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.84875910709026414					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101729	181101779	181383941	181383991	21579	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-16				ACTAATTTCCATTCTCCCCA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.35057540111471458					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101688	181101738	181383900	181383950	21580	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-17				AGGAGGCAGGCTTTGGTCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.27652707217840061					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101757	181101807	181383969	181384019	21581	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-18				GACAGTAAGACAAAAGAGGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.12646696232513921					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101818	181101868	181384030	181384080	21582	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-19				CCATTTGAAAGGGAGAAATG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.048240205743470557					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101807	181101857	181384019	181384069	21583	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-2				CCCACAAAGAGCCATTTGAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.22755230007452759					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101946	181101996	181384158	181384208	21584	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-3				TTGACTTGCTAACTTTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.002046442221507753					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101569	181101619	181383781	181383831	21585	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-4				AACATGTAACTGCCCTGGTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.148356224189689					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101665	181101715	181383877	181383927	21586	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-5				TGGGGGAATTAGTTCTCTCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.83396543197414585					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101746	181101796	181383958	181384008	21587	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-6				TGTCTTACTGTCTTGGTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.26321165882860847					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101705	181101755	181383917	181383967	21588	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-7				AAGTGTGATGGGTGTTCAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.55158944676862776					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101635	181101685	181383847	181383897	21589	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-8				AGTTGTGAAGCTGATACTTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.16224657076565721					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121189	chr3	181101610	181101660	181383822	181383872	21590	hg38	N/A	enh7704	N/A	Enhatls129677	enhancer	SOX2e+6-9				AAACCCTTTCAGCTCTAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.97110034533633161					SOX2	chr3	181711924	181714436	324758				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9318
enhrx-121157	chr3	180467291	180467341	180749503	180749553	21591	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-1				GGGTTAGGCCTACAGAAGCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.55159570438735661					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467268	180467318	180749480	180749530	21592	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-10				AAAGGGGTGGGGTATATAGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.98504990974864315					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467434	180467484	180749646	180749696	21593	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-11				AGGTCAGGGCAGCTTTTGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.17541456504714151					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467371	180467421	180749583	180749633	21594	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-12				GCCCTTTTTGTTCTGCACAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.1029963401174883					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467558	180467608	180749770	180749820	21595	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-13				TATGTAATTTCTCCCTTAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58994176196281978					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467347	180467397	180749559	180749609	21596	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-14				AGCAGTGGGGTCCCTGTTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.00046676620288322869					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467360	180467410	180749572	180749622	21597	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-15				TCTGCACAGTGGAAGCAGTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1248939588143199					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467336	180467386	180749548	180749598	21598	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-16				CCTGGCTGGAGCCTGGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1938001439685052					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467178	180467228	180749390	180749440	21599	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-17				GTCTGCTGCTGCCAAGAGCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.091769005831221981					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467514	180467564	180749726	180749776	21600	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-18				ATGCTTGCATAACAGAAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.41823477156722172					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467280	180467330	180749492	180749542	21601	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-19				ACAGAAGCGGGGAAAGGGGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8405383833505136					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467214	180467264	180749426	180749476	21602	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-2				GCGTAGGAAACTGAGCTAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.70984880648350535					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467490	180467540	180749702	180749752	21603	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-20				TTAAAAGTTGTTTTGAAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.61295708244684588					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467306	180467356	180749518	180749568	21604	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-3				CCTAACCCAGAGTTAGAATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.14767036111926329					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467449	180467499	180749661	180749711	21605	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-4				CTGTTTGTTAAGAGAAGGTC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.30019098866574417					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467230	180467280	180749442	180749492	21606	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-5				GAGAGCTTTTCCCAGAGCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.02260180376165789					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467318	180467368	180749530	180749580	21607	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-6				TTAGAATCTGGGGACAGACC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.51725723889487707					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467472	180467522	180749684	180749734	21608	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-7				ACAGGGATATTGCTCACTCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.749413857889308					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467400	180467450	180749612	180749662	21609	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-8				GGGACACTCAGTGATGCTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.35785728801983507					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121157	chr3	180467545	180467595	180749757	180749807	21610	hg38	N/A	N/A	N/A	Enhatls129645	enhancer	SOX2e+7-9				CCTAGAATAAAAACCAGCTA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.29713458711670387					CCDC39	chr3	180602857	180679489	68834				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9286
enhrx-121151	chr3	180431807	180431857	180714019	180714069	21611	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-1				TGGCCTAAATTGGTTTAGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.85375861484170235					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431575	180431625	180713787	180713837	21612	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-10				AGCTTTGGCCTTTGGTCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.18622784387022409					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431638	180431688	180713850	180713900	21613	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-11				AACAAGGAATTCTGTTGCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.39396534872894262					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431753	180431803	180713965	180714015	21614	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-12				ACACAGGAAGCTTCTTTCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.081974413056517037					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431532	180431582	180713744	180713794	21615	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-13				GCTAAGAAAATAACATGAAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.05777825647047883					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431831	180431881	180714043	180714093	21616	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-14				AACAGAAGTTGGTTTAGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.280868653037712					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431602	180431652	180713814	180713864	21617	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-15				CTTGCCTCATTATCTCAAGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.20021218859451609					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431560	180431610	180713772	180713822	21618	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-16				TCTTCTCTTTGAGTCAGCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.227921384834119					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431770	180431820	180713982	180714032	21619	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-17				GAGTCTTGCTTAGGCCCCCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.28731573184576958					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431620	180431670	180713832	180713882	21620	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-2				GATGGTTGCCAACAGTAGCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.64351434151975584					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431591	180431641	180713803	180713853	21621	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-3				TAATGAGGCAAGTCAGCCCG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.44993498178324659					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431737	180431787	180713949	180713999	21622	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-4				CTACCAACCTTATTAGACAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2788126758312518					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431880	180431930	180714092	180714142	21623	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-5				GTTCCATCTTAACTCTTTAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.087515912194282022					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431842	180431892	180714054	180714104	21624	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-6				TTATCACACTTAACAGAAGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.95928110690828727					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431902	180431952	180714114	180714164	21625	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-7				ATTGAATTCTCTCTCAATAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.446759648808253					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431654	180431704	180713866	180713916	21626	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-8				ACTGTCCTCAAACATGAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.48489306775142238					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121151	chr3	180431787	180431837	180713999	180714049	21627	hg38	N/A	N/A	N/A	Enhatls129639	enhancer	SOX2e+8-9				AGACTCTTCTCAAGTTTTAT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.62088006637325477					CCDC39	chr3	180602857	180679489	31974				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9280
enhrx-121121	chr3	180093747	180093797	180375959	180376009	21628	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-1				ATCCCCAGGAATTGTAATCT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.43140817381789148					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093860	180093910	180376072	180376122	21629	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-10				GCAAGCAGGGGAAATACCAG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1077677839622565					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093885	180093935	180376097	180376147	21630	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-11				TTCTCTCTCCTGTTGCCTTG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.58055673482743919					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093550	180093600	180375762	180375812	21631	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-12				TTGGTAATTTTTGAAAAACA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1420725749098454					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093718	180093768	180375930	180375980	21632	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-13				TCAAGATGAGATTTGGGTGA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.3454755676203991					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093815	180093865	180376027	180376077	21633	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-14				CTTACTATCATGAGAACAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.25143462241138159					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093934	180093984	180376146	180376196	21634	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-15				CTCAGGAAACTTACAATCGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.2091306484437663					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093874	180093924	180376086	180376136	21635	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-16				CAGGAGAGAGAAGTGCAAGC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.33976999977285521					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093733	180093783	180375945	180375995	21636	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-17				CATCTTGAATTGTAATCCCC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.60930608276754272					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093772	180093822	180375984	180376034	21637	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-18				GAGGCCTGGAGGGAGGTGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	direct	Highly Significant	5.8264109895446641					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180094000	180094050	180376212	180376262	21638	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-19				TGAGACTGGGTAACTTATAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.059421332346924573					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093683	180093733	180375895	180375945	21639	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-2				ATTTAACTGACCTACTGATA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.1260517477164674					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093958	180094008	180376170	180376220	21640	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-20				ACAGTTCCACATGGCTGGGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.47022565401078431					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093785	180093835	180375997	180376047	21641	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-21				AGGTGACTGGATCATGGCGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.94818551967098341					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093607	180093657	180375819	180375869	21642	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-3				GGGGAGGCTTCTGAGATCTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.77239990053889984					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093761	180093811	180375973	180376023	21643	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-4				TAATCTAGGAAGAGGCCTGG	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.45028791107831118					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093581	180093631	180375793	180375843	21644	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-5				AGGCCAAGCATATGTTGAAA	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.57213713984793335					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093627	180093677	180375839	180375889	21645	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-6				GCTTATTAAGCTTTATCTGT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-2.581971949425081					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093896	180093946	180376108	180376158	21646	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-7				GTTGCCTTGTGGAAAAGGAC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	0.46916273568879069					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093843	180093893	180376055	180376105	21647	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-8				CAGAGGCTTACAAAAACATC	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.398758005538675					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-121121	chr3	180093569	180093619	180375781	180375831	21648	hg38	N/A	N/A	N/A	Enhatls129609	enhancer	SOX2e+9-9				TGTTGAAATGGTCAAAATTT	enhancer knockout hits resulted in significantly reduced numbers of SOX17-GFP+ cells at DE-36h and delayed cell state transitions based on flow cytometric analysis	embryonic tissue(blastocyst)	hESCs	GATA6 (as well as EOMES)	indirect	Non Significant	-0.0141320246032903					TTC14	chr3	180602162	180617828	221626				CRISPRi	Dynamic-network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer-gene regulatory activity during cell state transitions	//doi.org/10.1038/s41588-023-01450-7	37488417	9250
enhrx-811	chr1	6356851	6364446	6296791	6304386	21649	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21650	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21651	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21652	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21653	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21654	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1	sgRNA IDs also given in paper but not mentioned here			GGTGGTTTAGCTGTGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21655	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21656	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21657	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21658	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21659	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21660	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TTTTCAGGATGGAAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21661	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21662	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21663	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21664	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21665	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21666	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGATAAATGGGGCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21667	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21668	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21669	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21670	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21671	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21672	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCACGTGACAGTCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21673	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21674	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21675	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21676	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21677	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21678	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCACACTGCATGATGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21679	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21680	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21681	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21682	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21683	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21684	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCCCTGACCCAACACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21685	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21686	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21687	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21688	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21689	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21690	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGACGCAAATTGTTGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21691	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21692	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21693	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21694	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21695	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21696	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGTGGGCTTGGTTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21697	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21698	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21699	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21700	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21701	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21702	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GCTGGACGGTGACATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21703	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21704	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21705	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21706	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21707	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21708	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCGCTGATCTAAACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21709	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21710	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21711	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21712	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21713	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21714	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TGGGATTACGACAGCCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21715	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21716	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21717	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21718	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21719	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21720	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				AACAGTGACTCACGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21721	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21722	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21723	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21724	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21725	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21726	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CCTGACTCTGGCAGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21727	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21728	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21729	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21730	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21731	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21732	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GAGGTGCAGATGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21733	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21734	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21735	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21736	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21737	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21738	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				TCGTAAAGTTGGCCTTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21739	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21740	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21741	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21742	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21743	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21744	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				GTTTGGCCTTGCGACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21745	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21746	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21747	hg19	N/A	enh26500	fant195	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21748	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21749	hg19	N/A	enh26500	fant196	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6356851	6364446	6296791	6304386	21750	hg19	N/A	enh26500	N/A	Enhatls846	enhancer	E_1				CAGAAACCCACCCGAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21751	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21752	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21753	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21754	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21755	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21756	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21757	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21758	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				GGAAACAGCTGGAACGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21759	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21760	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21761	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21762	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21763	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21764	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21765	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21766	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				AGAAGAGATCTGTACTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21767	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21768	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21769	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21770	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21771	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21772	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21773	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21774	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				CATTATTAACGAGTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21775	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21776	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21777	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21778	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21779	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21780	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21781	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21782	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				ATGCTAGTCTTTGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21783	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21784	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21785	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21786	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21787	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21788	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21789	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21790	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				TTAATGCCTGCTGAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21791	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21792	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21793	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21794	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21795	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21796	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21797	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21798	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				CTCACAGCTATCAGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21799	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21800	hg19	N/A	N/A	fant197	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21801	hg19	N/A	N/A	N/A	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21802	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21803	hg19	N/A	enh26501	fant198	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21804	hg19	N/A	enh26501	N/A	Enhatls846	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21805	hg19	N/A	enh26501	N/A	N/A	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-811	chr1	6366870	6382232	6306810	6322172	21806	hg19	N/A	enh26501	N/A	Enhatls847	enhancer	E_2				CTGGCACCCATTTTTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					ACOT7	chr1	6264268	6393767	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	810
enhrx-896	chr1	7461930	7462942	7401870	7402882	21807	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				AGCCATAAAGACCTAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21808	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				CTGCTAAGGAAACAGCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21809	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				CTTTAAGGTGACTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21810	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				ATGAGTGACTAAGGCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21811	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				CACACTCTGTAGGTCTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21812	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				GCAAAACAAGGGAGGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21813	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				CTCAAGCTGGATCTCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21814	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				GTGCTGCCTATCATGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-896	chr1	7461930	7462942	7401870	7402882	21815	hg19	N/A	enh11453	N/A	Enhatls951	enhancer	E_6				CCAAAAATATGAACGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG5	direct	Highly Significant	NA					CAMTA1	chr1	6785453	7769706	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	895
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21816	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				ACAGTTTTGATCTTTTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21817	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				ACAGTTTTGATCTTTTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21818	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				CACATTAGAAACGTAAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21819	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				CACATTAGAAACGTAAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21820	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				ACAAAGAGCTCACACAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21821	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				ACAAAGAGCTCACACAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21822	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				GCGGGACTCGCAACAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21823	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				GCGGGACTCGCAACAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21824	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				GCAAAGGACAAATACCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21825	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				GCAAAGGACAAATACCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21826	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				TGTGAGGCCTGTTTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21827	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				TGTGAGGCCTGTTTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21828	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				TCAATTTAGCAGAGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21829	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				TCAATTTAGCAGAGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21830	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				CATCCTCTCCCAAAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21831	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				CATCCTCTCCCAAAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21832	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				GTTTGCCAACAAGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21833	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				GTTTGCCAACAAGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21834	hg19	N/A	enh90649	N/A	Enhatls1104	enhancer	E_11				GTAACCATTCCAAATTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	6002				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1024	chr1	9592586	9594541	9532527	9534482	21835	hg19	N/A	N/A	N/A	Enhatls1104	enhancer	E_11				GTAACCATTCCAAATTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					SLC25A33	chr1	9539464	9585173	5004				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1023
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21836	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				ATACCGTTAACTCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21837	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				ATACCGTTAACTCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21838	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GTCTCTTCAACCGCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21839	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GTCTCTTCAACCGCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21840	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCGCACTCGGAATGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21841	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCGCACTCGGAATGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21842	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCCTGGTAAACTGTAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21843	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCCTGGTAAACTGTAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21844	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCGGACGGCCTGCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21845	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCGGACGGCCTGCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21846	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				ACGTGCCCGCCCACCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21847	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				ACGTGCCCGCCCACCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21848	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCGGCTCCCTCCAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21849	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCGGCTCCCTCCAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21850	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				CACTCACTGGGCCATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21851	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				CACTCACTGGGCCATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21852	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GGGAGGCGTCGGAGAGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21853	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GGGAGGCGTCGGAGAGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21854	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				CCCGAGACGCCGTAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21855	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				CCCGAGACGCCGTAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21856	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GTGTCCCTGCAGACTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21857	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GTGTCCCTGCAGACTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21858	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCGCGCACGCTGCAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21859	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCGCGCACGCTGCAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21860	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				CTCGACGCGCTGCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21861	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				CTCGACGCGCTGCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21862	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GCGCGATGTCAGCTCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21863	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GCGCGATGTCAGCTCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21864	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				CGCCGCTTACCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21865	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				CGCCGCTTACCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1158	chr1	10458040	10460497	10397983	10400440	21866	hg19	N/A	N/A	N/A	Enhatls1254	enhancer	E_13				GTTCCCGGGCGCTTTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1157
enhrx-1159	chr1	10458040	10460497	10397983	10400440	21867	hg19	N/A	N/A	N/A	Enhatls1255	enhancer	E_13				GTTCCCGGGCGCTTTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					PGD	chr1	10398591	10420511	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1158
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21868	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21869	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21870	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21871	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21872	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21873	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21874	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21875	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				AGTCTTTGTGACGCTATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21876	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21877	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21878	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21879	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21880	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21881	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21882	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21883	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				TTACATGATCTGTAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21884	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21885	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21886	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21887	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21888	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21889	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21890	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21891	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GGAGGTGGCCGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21892	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21893	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21894	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21895	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21896	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21897	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21898	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21899	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CCCCTGGCGGCGCTCCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21900	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21901	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21902	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21903	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21904	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21905	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21906	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21907	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GCGGCCCGTCGCTCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21908	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21909	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21910	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21911	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21912	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21913	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21914	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21915	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GGCCGACCCTGGGCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21916	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21917	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21918	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21919	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21920	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21921	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21922	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21923	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CAACAGGTACAGGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21924	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21925	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21926	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21927	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21928	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21929	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21930	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21931	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GTGCCGATGAGAAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21932	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21933	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21934	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21935	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21936	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21937	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21938	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21939	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GTTGGCTTAACTGCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21940	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21941	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21942	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21943	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21944	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21945	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21946	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21947	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				TTCATCGCAAGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21948	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21949	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21950	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21951	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21952	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21953	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21954	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21955	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CAGGTGACGCCCGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21956	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21957	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21958	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21959	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21960	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21961	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21962	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21963	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				GATACGATCACAAGTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21964	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21965	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21966	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21967	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21968	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21969	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21970	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21971	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CGCTGATGAAAGGAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21972	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21973	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21974	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21975	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21976	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21977	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21978	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21979	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				AGAGGCTTAAAAGCAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21980	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21981	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21982	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21983	hg19	N/A	enh58	N/A	Enhatls1266	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21984	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21985	hg19	N/A	enh58	N/A	N/A	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21986	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS-CORT	chr1	10430101	10452153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1170	chr1	10488523	10494184	10428466	10434127	21987	hg19	N/A	enh58	N/A	Enhatls1267	enhancer	E_14				CGGGAATGAGCTCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	direct	Highly Significant	NA					CENPS	chr1	10430432	10442808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1169
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21988	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21989	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21990	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21991	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21992	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21993	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCATGTGAACCCTCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21994	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21995	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21996	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21997	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21998	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	21999	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGTGTCATCTGTTTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22000	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22001	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22002	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22003	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22004	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22005	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GATGATGACGCGAAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22006	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22007	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22008	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22009	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22010	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22011	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				CAATAATTAAAACCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22012	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22013	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22014	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22015	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22016	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22017	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TCATTCTCCCAACAAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22018	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22019	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22020	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22021	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22022	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22023	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGGGTGACACTGGGCAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22024	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22025	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22026	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22027	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22028	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22029	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTATGGTTGGCATCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22030	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22031	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22032	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22033	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22034	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22035	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTCAGCCCACGGTGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22036	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22037	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22038	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22039	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22040	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22041	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				ATAATCCTGAAGCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22042	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22043	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22044	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22045	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22046	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22047	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				CCAACCTCACTCCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22048	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22049	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22050	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22051	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22052	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22053	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGAGGAAGCGCTGGGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22054	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22055	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22056	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22057	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22058	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22059	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				ATTGTAGGAGTAGACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22060	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22061	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22062	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22063	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22064	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22065	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GAAAGAAACTACTATTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22066	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22067	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22068	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22069	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22070	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22071	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCAATGTGAAAAGGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22072	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22073	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22074	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22075	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22076	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22077	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GGAATCGAATGGCTCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22078	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22079	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22080	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22081	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22082	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22083	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				AGGGCCTCAGGCCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22084	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22085	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22086	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22087	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22088	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22089	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TTCTTTGCCAACCCACTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22090	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22091	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22092	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22093	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22094	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22095	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GAGCCTGCAGCCTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22096	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22097	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22098	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22099	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22100	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22101	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGAATTCAGCGAATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22102	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22103	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22104	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22105	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22106	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22107	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				GCGGGTACCCGGCCGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22108	hg19	N/A	enh42881	N/A	Enhatls1315	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22109	hg19	N/A	enh42881	N/A	N/A	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22110	hg19	N/A	enh42881	N/A	Enhatls1316	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22111	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22112	hg19	N/A	N/A	fant365	Enhatls1316	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1212	chr1	11033385	11042703	10973328	10982646	22113	hg19	N/A	N/A	N/A	Enhatls1316	enhancer	E_16				TGGGAGAGGAATTCCGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PGD	indirect	Non Significant	NA					C1orf127	chr1	10946472	10982076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1211
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22114	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22115	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22116	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22117	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22118	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22119	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22120	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22121	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22122	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22123	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22124	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22125	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22126	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22127	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22128	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22129	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22130	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22131	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22132	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22133	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22134	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGACCAAGCACGCTGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22135	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22136	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22137	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22138	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22139	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22140	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22141	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22142	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22143	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22144	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22145	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22146	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22147	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22148	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22149	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22150	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22151	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22152	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22153	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22154	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22155	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TACCCAGGTGGGGACCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22156	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22157	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22158	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22159	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22160	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22161	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22162	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22163	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22164	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22165	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22166	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22167	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22168	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22169	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22170	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22171	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22172	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22173	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22174	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22175	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22176	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGGCATCCTGAACTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22177	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22178	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22179	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22180	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22181	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22182	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22183	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22184	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22185	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22186	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22187	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22188	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22189	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22190	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22191	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22192	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22193	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22194	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22195	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22196	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22197	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTTCCTGGTCAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22198	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22199	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22200	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22201	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22202	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22203	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22204	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22205	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22206	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22207	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22208	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22209	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22210	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22211	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22212	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22213	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22214	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22215	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22216	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22217	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22218	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTGACTCTTCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22219	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22220	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22221	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22222	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22223	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22224	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22225	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22226	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22227	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22228	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22229	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22230	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22231	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22232	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22233	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22234	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22235	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22236	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22237	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22238	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22239	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGAGACAGGATAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22240	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22241	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22242	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22243	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22244	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22245	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22246	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22247	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22248	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22249	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22250	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22251	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22252	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22253	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22254	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22255	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22256	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22257	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22258	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22259	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22260	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGTGGGTAGAGGTCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22261	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22262	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22263	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22264	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22265	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22266	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22267	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22268	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22269	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22270	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22271	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22272	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22273	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22274	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22275	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22276	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22277	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22278	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22279	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22280	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22281	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGTGGTGAACACGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22282	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22283	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22284	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22285	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22286	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22287	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22288	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22289	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22290	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22291	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22292	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22293	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22294	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22295	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22296	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22297	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22298	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22299	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22300	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22301	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22302	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGGTGCATACCCAGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22303	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22304	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22305	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22306	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22307	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22308	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22309	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22310	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22311	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22312	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22313	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22314	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22315	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22316	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22317	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22318	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22319	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22320	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22321	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22322	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22323	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGACAAGGTCTGCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22324	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22325	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22326	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22327	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22328	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22329	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22330	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22331	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22332	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22333	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22334	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22335	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22336	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22337	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22338	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22339	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22340	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22341	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22342	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22343	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22344	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGAGGGGACATTTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22345	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22346	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22347	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22348	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22349	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22350	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22351	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22352	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22353	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22354	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22355	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22356	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22357	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22358	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22359	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22360	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22361	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22362	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22363	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22364	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22365	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AAGTGCATGACTAATACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22366	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22367	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22368	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22369	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22370	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22371	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22372	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22373	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22374	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22375	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22376	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22377	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22378	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22379	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22380	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22381	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22382	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22383	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22384	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22385	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22386	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGAGAAAGGCCTTCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22387	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22388	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22389	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22390	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22391	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22392	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22393	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22394	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22395	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22396	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22397	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22398	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22399	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22400	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22401	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22402	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22403	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22404	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22405	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22406	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22407	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGCACAGATTTTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22408	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22409	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22410	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22411	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22412	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22413	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22414	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22415	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22416	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22417	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22418	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22419	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22420	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22421	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22422	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22423	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22424	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22425	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22426	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22427	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22428	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGAAATTGCTTCCCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22429	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22430	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22431	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22432	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22433	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22434	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22435	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22436	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22437	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22438	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22439	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22440	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22441	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22442	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22443	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22444	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22445	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22446	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22447	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22448	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22449	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TGTGTGAGCAGAGGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22450	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22451	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22452	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22453	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22454	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22455	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22456	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22457	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22458	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22459	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22460	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22461	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22462	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22463	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22464	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22465	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22466	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22467	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22468	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22469	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22470	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCGGCTGTTTGTGTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22471	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22472	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22473	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22474	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22475	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22476	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22477	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22478	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22479	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22480	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22481	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22482	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22483	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22484	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22485	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22486	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22487	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22488	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22489	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22490	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22491	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TATGTGCCTGAGCTCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22492	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22493	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22494	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22495	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22496	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22497	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22498	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22499	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22500	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22501	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22502	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22503	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22504	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22505	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22506	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22507	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22508	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22509	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22510	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22511	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22512	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGTCATGCAGCAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22513	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22514	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22515	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22516	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22517	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22518	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22519	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22520	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22521	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22522	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22523	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22524	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22525	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22526	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22527	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22528	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22529	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22530	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22531	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22532	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22533	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTTGGAGATTCCCTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22534	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22535	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22536	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22537	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22538	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22539	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22540	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22541	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22542	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22543	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22544	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22545	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22546	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22547	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22548	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22549	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22550	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22551	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22552	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22553	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22554	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CCGCTGGTCAGGTGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22555	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22556	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22557	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22558	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22559	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22560	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22561	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22562	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22563	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22564	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22565	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22566	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22567	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22568	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22569	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22570	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22571	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22572	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22573	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22574	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22575	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGCACAGGAAGCGGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22576	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22577	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22578	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22579	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22580	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22581	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22582	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22583	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22584	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22585	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22586	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22587	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22588	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22589	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22590	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22591	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22592	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22593	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22594	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22595	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22596	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGGCAGGGCGGGGGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22597	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22598	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22599	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22600	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22601	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22602	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22603	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22604	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22605	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22606	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22607	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22608	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22609	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22610	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22611	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22612	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22613	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22614	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22615	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22616	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22617	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGAAAGAGTTAAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22618	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22619	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22620	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22621	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22622	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22623	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22624	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22625	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22626	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22627	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22628	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22629	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22630	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22631	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22632	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22633	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22634	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22635	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22636	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22637	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22638	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTTTGTCCGTTTCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22639	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22640	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22641	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22642	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22643	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22644	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22645	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22646	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22647	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22648	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22649	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22650	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22651	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22652	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22653	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22654	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22655	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22656	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22657	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22658	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22659	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ACCAGACCCAGAGCGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22660	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22661	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22662	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22663	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22664	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22665	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22666	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22667	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22668	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22669	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22670	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22671	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22672	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22673	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22674	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22675	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22676	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22677	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22678	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22679	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22680	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTACATTGAGGGAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22681	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22682	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22683	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22684	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22685	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22686	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22687	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22688	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22689	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22690	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22691	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22692	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22693	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22694	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22695	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22696	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22697	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22698	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22699	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22700	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22701	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GATGGCAGGGTCTGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22702	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22703	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22704	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22705	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22706	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22707	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22708	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22709	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22710	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22711	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22712	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22713	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22714	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22715	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22716	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22717	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22718	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22719	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22720	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22721	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22722	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGCTGAGTCAGGGATTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22723	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22724	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22725	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22726	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22727	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22728	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22729	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22730	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22731	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22732	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22733	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22734	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22735	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22736	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22737	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22738	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22739	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22740	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22741	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22742	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22743	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CTGGGCGCCGCTGCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22744	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22745	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22746	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22747	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22748	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22749	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22750	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22751	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22752	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22753	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22754	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22755	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22756	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22757	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22758	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22759	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22760	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22761	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22762	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22763	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22764	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTCCCTGCCACGCAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22765	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22766	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22767	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22768	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22769	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22770	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22771	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22772	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22773	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22774	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22775	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22776	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22777	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22778	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22779	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22780	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22781	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22782	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22783	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22784	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22785	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTAGACGGGTGTCGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22786	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22787	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22788	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22789	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22790	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22791	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22792	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22793	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22794	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22795	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22796	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22797	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22798	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22799	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22800	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22801	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22802	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22803	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22804	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22805	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22806	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGCTGCTGAGAGAAGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22807	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22808	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22809	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22810	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22811	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22812	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22813	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22814	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22815	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22816	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22817	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22818	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22819	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22820	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22821	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22822	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22823	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22824	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22825	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22826	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22827	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ATTTTGGTGGGAGGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22828	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22829	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22830	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22831	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22832	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22833	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22834	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22835	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22836	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22837	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22838	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22839	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22840	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22841	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22842	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22843	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22844	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22845	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22846	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22847	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22848	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGGGTTCCACGAACTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22849	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22850	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22851	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22852	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22853	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22854	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22855	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22856	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22857	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22858	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22859	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22860	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22861	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22862	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22863	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22864	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22865	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22866	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22867	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22868	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22869	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTGGGCTGATCTTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22870	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22871	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22872	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22873	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22874	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22875	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22876	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22877	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22878	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22879	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22880	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22881	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22882	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22883	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22884	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22885	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22886	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22887	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22888	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22889	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22890	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGTGTCTCTCCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22891	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22892	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22893	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22894	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22895	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22896	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22897	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22898	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22899	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22900	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22901	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22902	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22903	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22904	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22905	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22906	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22907	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22908	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22909	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22910	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22911	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ATCCTCGCACAAGAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22912	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22913	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22914	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22915	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22916	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22917	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22918	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22919	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22920	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22921	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22922	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22923	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22924	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22925	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22926	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22927	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22928	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22929	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22930	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22931	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22932	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGGGGGGCTCGCTCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22933	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22934	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22935	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22936	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22937	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22938	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22939	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22940	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22941	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22942	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22943	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22944	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22945	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22946	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22947	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22948	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22949	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22950	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22951	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22952	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22953	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTAGGGAACTTCTCATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22954	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22955	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22956	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22957	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22958	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22959	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22960	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22961	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22962	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22963	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22964	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22965	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22966	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22967	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22968	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22969	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22970	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22971	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22972	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22973	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22974	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				ACACTGAAGCCCTTTGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22975	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22976	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22977	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22978	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22979	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22980	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22981	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22982	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22983	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	22984	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22985	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22986	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22987	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22988	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22989	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22990	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	22991	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22992	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22993	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22994	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	22995	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCGGGACGTTAAGGAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22996	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22997	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22998	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	22999	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23000	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23001	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23002	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23003	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23004	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23005	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23006	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23007	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23008	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23009	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23010	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23011	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23012	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23013	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23014	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23015	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23016	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGGAATGCAGGCCAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23017	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23018	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23019	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23020	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23021	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23022	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23023	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23024	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23025	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23026	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23027	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23028	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23029	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23030	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23031	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23032	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23033	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23034	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23035	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23036	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23037	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAGCAATGTGGATTTTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23038	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23039	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23040	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23041	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23042	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23043	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23044	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23045	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23046	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23047	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23048	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23049	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23050	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23051	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23052	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23053	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23054	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23055	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23056	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23057	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23058	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGTTCACATGGAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23059	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23060	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23061	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23062	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23063	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23064	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23065	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23066	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23067	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23068	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23069	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23070	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23071	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23072	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23073	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23074	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23075	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23076	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23077	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23078	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23079	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CCACGCGGTTGCAGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23080	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23081	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23082	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23083	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23084	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23085	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23086	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23087	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23088	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23089	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23090	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23091	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23092	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23093	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23094	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23095	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23096	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23097	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23098	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23099	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23100	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GCTGCGATCGAGGCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23101	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23102	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23103	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23104	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23105	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23106	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23107	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23108	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23109	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23110	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23111	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23112	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23113	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23114	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23115	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23116	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23117	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23118	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23119	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23120	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23121	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TACCTGGTGTCGCCCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23122	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23123	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23124	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23125	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23126	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23127	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23128	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23129	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23130	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23131	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23132	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23133	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23134	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23135	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23136	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23137	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23138	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23139	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23140	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23141	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23142	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CAAGGAGCGCCGGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23143	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23144	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23145	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23146	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23147	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23148	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23149	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23150	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23151	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23152	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23153	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23154	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23155	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23156	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23157	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23158	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23159	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23160	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23161	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23162	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23163	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TTCCTTGCCCTGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23164	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23165	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23166	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23167	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23168	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23169	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23170	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23171	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23172	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23173	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23174	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23175	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23176	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23177	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23178	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23179	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23180	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23181	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23182	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23183	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23184	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CGGACCGAGAGCGAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23185	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23186	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23187	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23188	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23189	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23190	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23191	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23192	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23193	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23194	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23195	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23196	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23197	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23198	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23199	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23200	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23201	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23202	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23203	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23204	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23205	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AGAAGTTGCGCGCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23206	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23207	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23208	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23209	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23210	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23211	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23212	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23213	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23214	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23215	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23216	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23217	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23218	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23219	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23220	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23221	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23222	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23223	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23224	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23225	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23226	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGCGTTGGTGACGTCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23227	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23228	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23229	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23230	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23231	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23232	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23233	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23234	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23235	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23236	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23237	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23238	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23239	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23240	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23241	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23242	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23243	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23244	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23245	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23246	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23247	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGGAGCCCGCGAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23248	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23249	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23250	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23251	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23252	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23253	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23254	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23255	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23256	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23257	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23258	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23259	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23260	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23261	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23262	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23263	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23264	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23265	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23266	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23267	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23268	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				TCTGAGCCTGGTATCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23269	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23270	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23271	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23272	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23273	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23274	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23275	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23276	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23277	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23278	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23279	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23280	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23281	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23282	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23283	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23284	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23285	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23286	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23287	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23288	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23289	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AATGCGACTGAGCTCAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23290	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23291	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23292	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23293	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23294	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23295	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23296	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23297	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23298	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23299	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23300	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23301	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23302	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23303	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23304	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23305	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23306	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23307	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23308	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23309	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23310	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGAGTCCAGAGGTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23311	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23312	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23313	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23314	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23315	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23316	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23317	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23318	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23319	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23320	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23321	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23322	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23323	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23324	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23325	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23326	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23327	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23328	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23329	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23330	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23331	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACAAACGAACGGTAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23332	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23333	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23334	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23335	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23336	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23337	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23338	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23339	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23340	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23341	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23342	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23343	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23344	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23345	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23346	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23347	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23348	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23349	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23350	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23351	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23352	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CGTGTGTGAGCTCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23353	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23354	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23355	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23356	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23357	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23358	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23359	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23360	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23361	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23362	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23363	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23364	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23365	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23366	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23367	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23368	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23369	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23370	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23371	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23372	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23373	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				AAGCTTACACTGCGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23374	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23375	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23376	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23377	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23378	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23379	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23380	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23381	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23382	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23383	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23384	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23385	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23386	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23387	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23388	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23389	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23390	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23391	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23392	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23393	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23394	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				CATCGTCATACTGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23395	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23396	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23397	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23398	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23399	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23400	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23401	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23402	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23403	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23404	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23405	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23406	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23407	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23408	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23409	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23410	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23411	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23412	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23413	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23414	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23415	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACGTCATGCCCAGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23416	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23417	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23418	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23419	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23420	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23421	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23422	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23423	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23424	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23425	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23426	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23427	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23428	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23429	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23430	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23431	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23432	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23433	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23434	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23435	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23436	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGGATTCCCGCTTCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23437	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23438	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23439	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23440	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23441	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23442	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23443	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23444	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23445	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23446	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23447	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23448	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23449	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23450	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23451	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23452	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23453	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23454	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23455	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23456	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23457	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GGAAGGCCCCAGGGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23458	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23459	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23460	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23461	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23462	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23463	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23464	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23465	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23466	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23467	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23468	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23469	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23470	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23471	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23472	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23473	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23474	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23475	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23476	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23477	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23478	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GTGCTGCTCACAGAGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23479	hg19	N/A	N/A	N/A	Enhatls2021	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23480	hg19	N/A	enh11544	N/A	Enhatls2021	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23481	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23482	hg19	N/A	enh11544	N/A	Enhatls2022	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23483	hg19	N/A	enh11544	N/A	N/A	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23484	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23485	hg19	N/A	enh11544	fant516	Enhatls2023	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23486	hg19	N/A	enh11544	N/A	Enhatls2023	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1813	chr1	16462334	16493773	16135839	16167278	23487	hg19	N/A	N/A	N/A	Enhatls2023	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1812
enhrx-1814	chr1	16462334	16493773	16135839	16167278	23488	hg19	N/A	N/A	N/A	Enhatls2024	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1813
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23489	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23490	hg19	N/A	N/A	fant517	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23491	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23492	hg19	N/A	N/A	fant518	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23493	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23494	hg19	N/A	N/A	fant519	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1815	chr1	16462334	16493773	16135839	16167278	23495	hg19	N/A	N/A	N/A	Enhatls2025	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1814
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23496	hg19	N/A	enh11545	N/A	N/A	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	3462				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23497	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23498	hg19	N/A	enh11545	fant520	Enhatls2026	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16462334	16493773	16135839	16167278	23499	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_19				GACCTGCTCGACGTTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23500	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23501	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23502	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23503	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23504	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23505	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23506	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23507	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23508	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGATCTCCTAGCAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23509	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23510	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23511	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23512	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23513	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23514	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23515	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23516	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23517	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCCCGTGAACTCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23518	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23519	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23520	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23521	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23522	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23523	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23524	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23525	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23526	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCTGTATGCCCCAGTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23527	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23528	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23529	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23530	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23531	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23532	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23533	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23534	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23535	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCCCCTTATGAAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23536	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23537	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23538	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23539	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23540	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23541	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23542	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23543	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23544	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGGACAAAGCAGCGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23545	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23546	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23547	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23548	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23549	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23550	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23551	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23552	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23553	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAGATCCCCCAGAGAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23554	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23555	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23556	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23557	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23558	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23559	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23560	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23561	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23562	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACAAAGGCTGGGAGTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23563	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23564	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23565	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23566	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23567	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23568	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23569	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23570	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23571	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCAGAGCCCGACCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23572	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23573	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23574	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23575	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23576	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23577	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23578	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23579	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23580	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCTCGGGCAAACAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23581	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23582	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23583	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23584	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23585	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23586	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23587	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23588	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23589	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTACCTTGCCACAGGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23590	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23591	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23592	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23593	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23594	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23595	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23596	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23597	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23598	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGGATGGAGTGAGGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23599	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23600	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23601	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23602	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23603	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23604	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23605	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23606	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23607	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATTTGAGACCTAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23608	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23609	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23610	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23611	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23612	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23613	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23614	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23615	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23616	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCCTGCCTGAGCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23617	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23618	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23619	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23620	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23621	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23622	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23623	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23624	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23625	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTAGTGGGTAGGAGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23626	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23627	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23628	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23629	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23630	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23631	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23632	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23633	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23634	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGTGACTTGTCCCCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23635	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23636	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23637	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23638	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23639	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23640	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23641	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23642	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23643	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCCGGGTGCCAGGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23644	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23645	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23646	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23647	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23648	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23649	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23650	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23651	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23652	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGTCAGCAGCAGAGATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23653	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23654	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23655	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23656	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23657	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23658	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23659	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23660	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23661	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGAGAGAGATAGGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23662	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23663	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23664	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23665	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23666	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23667	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23668	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23669	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23670	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCAGACCAGGCCTGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23671	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23672	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23673	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23674	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23675	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23676	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23677	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23678	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23679	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGCTAACCCAGAAGATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23680	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23681	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23682	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23683	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23684	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23685	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23686	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23687	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23688	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCCTGAAGAGCAAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23689	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23690	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23691	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23692	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23693	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23694	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23695	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23696	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23697	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTAGGGCCAGAGCCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23698	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23699	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23700	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23701	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23702	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23703	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23704	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23705	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23706	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				AGATCAGCCTGGTCCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23707	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23708	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23709	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23710	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23711	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23712	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23713	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23714	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23715	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGAAAACAAACACTTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23716	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23717	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23718	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23719	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23720	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23721	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23722	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23723	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23724	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CCGAGCACTGGGTCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23725	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23726	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23727	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23728	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23729	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23730	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23731	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23732	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23733	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TGGGATGGGAAGGTCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23734	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23735	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23736	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23737	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23738	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23739	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23740	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23741	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23742	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATACGGGAGCATCCTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23743	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23744	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23745	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23746	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23747	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23748	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23749	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23750	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23751	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ATATAAGCACTGCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23752	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23753	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23754	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23755	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23756	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23757	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23758	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23759	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23760	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATTGAACTGAGCCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23761	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23762	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23763	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23764	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23765	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23766	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23767	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23768	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23769	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTCATGCACTCACTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23770	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23771	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23772	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23773	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23774	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23775	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23776	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23777	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23778	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACATCATAGGACCAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23779	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23780	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23781	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23782	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23783	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23784	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23785	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23786	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23787	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GAAGGGAGGGCATAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23788	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23789	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23790	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23791	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23792	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23793	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23794	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23795	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23796	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGCTGTGTCTGTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23797	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23798	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23799	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23800	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23801	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23802	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23803	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23804	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23805	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACCCCGCTATCCCAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23806	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23807	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23808	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23809	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23810	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23811	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23812	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23813	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23814	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GGGCAATTGCGGTTCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23815	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23816	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23817	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23818	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23819	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23820	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23821	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23822	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23823	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				ACTCATGATGATGACGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23824	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23825	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23826	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23827	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23828	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23829	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23830	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23831	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23832	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GTTCTGGACTGAAATCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23833	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23834	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23835	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23836	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23837	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23838	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23839	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23840	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23841	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GACTCCTCATCTGTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23842	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23843	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23844	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23845	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23846	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23847	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23848	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23849	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23850	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGCCTCATTTAAGTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23851	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23852	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23853	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23854	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23855	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23856	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23857	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23858	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23859	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTCGGCTGCTGGAAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23860	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23861	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23862	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23863	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23864	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23865	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23866	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23867	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23868	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TCATGAGCTGCCCTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23869	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23870	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23871	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23872	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23873	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23874	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23875	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23876	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23877	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				TTGGGTGGGGCACAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23878	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23879	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23880	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23881	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23882	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23883	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23884	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23885	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23886	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CTGTTCTTCACGCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23887	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23888	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23889	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23890	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23891	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23892	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23893	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23894	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23895	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				CGTTGTAGCAGGAGGGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23896	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	6644				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23897	hg19	N/A	enh11545	fant521	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	16885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23898	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23899	hg19	N/A	enh11545	fant522	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23900	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	17746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23901	hg19	N/A	enh11545	fant523	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					EPHA2	chr1	16124336	16156069	19820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23902	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15955				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23903	hg19	N/A	enh11545	fant524	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	15743				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1816	chr1	16495194	16520371	16168699	16193876	23904	hg19	N/A	enh11545	N/A	Enhatls2026	enhancer	E_20				GCATCAGAAATACAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					ARHGEF19	chr1	16197853	16212652	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1815
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23905	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TTGTGATTTTAGGAGAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23906	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				TTGTGATTTTAGGAGAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23907	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TTGTGATTTTAGGAGAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23908	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				TTGTGATTTTAGGAGAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23909	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CTCTTAAAGAAGGGGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23910	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				CTCTTAAAGAAGGGGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23911	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CTCTTAAAGAAGGGGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23912	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				CTCTTAAAGAAGGGGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23913	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CACGCTTCTCCATCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23914	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				CACGCTTCTCCATCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23915	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CACGCTTCTCCATCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23916	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				CACGCTTCTCCATCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23917	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				GTCTAGGATTTGGTGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23918	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				GTCTAGGATTTGGTGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23919	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				GTCTAGGATTTGGTGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23920	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				GTCTAGGATTTGGTGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23921	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TGAGTTATGATTGCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23922	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				TGAGTTATGATTGCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23923	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TGAGTTATGATTGCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23924	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				TGAGTTATGATTGCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23925	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				AGCTGAGACCATCTGCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23926	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				AGCTGAGACCATCTGCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23927	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				AGCTGAGACCATCTGCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23928	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				AGCTGAGACCATCTGCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23929	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CCACCTGTAGAAATAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23930	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				CCACCTGTAGAAATAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23931	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CCACCTGTAGAAATAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23932	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				CCACCTGTAGAAATAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23933	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CTTACTGGTGATGCTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23934	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				CTTACTGGTGATGCTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23935	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				CTTACTGGTGATGCTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23936	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				CTTACTGGTGATGCTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23937	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				GTTACTAGAACACTGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23938	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				GTTACTAGAACACTGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23939	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				GTTACTAGAACACTGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23940	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				GTTACTAGAACACTGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23941	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TCTACATGCTCAGGTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23942	hg19	N/A	enh87	N/A	Enhatls2119	enhancer	E_22				TCTACATGCTCAGGTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	5619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23943	hg19	N/A	enh87	N/A	N/A	enhancer	E_22				TCTACATGCTCAGGTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1903	chr1	16944747	16948222	16618252	16621727	23944	hg19	N/A	enh87	N/A	Enhatls2120	enhancer	E_22				TCTACATGCTCAGGTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					NBPF1	chr1	16562318	16613487	6549				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1902
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23945	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				AATAGCAGACTGGAACGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23946	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				TTAAGTAATCACTTCTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23947	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				ACAAGGGCGAGACAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23948	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GGGTGGGGCGGAAGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23949	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GGGTGATTGGGGATTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23950	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				AGTGGTTTACTGTAAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23951	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GTCTCTTATTTTTCCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23952	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				CCTTGCAGCCAAGCAAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23953	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				ACAGTCTGTTATCCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23954	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GAATAGTGAGAAATGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23955	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				AAACTGTGACAGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23956	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				ATGATGGCACCAAACTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23957	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				ATTTTAATCCTCTGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23958	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GATTCCCACAACAGTAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-1936	chr1	17228247	17235738	16901752	16909243	23959	hg19	N/A	enh90	N/A	Enhatls2168	enhancer	E_25				GACTATAGGCGAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF19	direct	Highly Significant	NA					CROCC	chr1	16921930	16972964	5311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1935
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23960	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23961	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23962	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23963	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23964	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23965	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTTGTCATCATCTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23966	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23967	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23968	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23969	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23970	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23971	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGTCAGAGAAAACTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23972	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23973	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23974	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23975	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23976	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23977	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GTAATGACACTTGGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23978	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23979	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23980	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23981	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23982	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23983	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCAGTGTAATGACAGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23984	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23985	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23986	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23987	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23988	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23989	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				AGACGCACTTGGCCTTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23990	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23991	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23992	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23993	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23994	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23995	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				GCTTGTTCTGAGCAGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23996	hg19	N/A	enh11650	N/A	N/A	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23997	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23998	hg19	N/A	enh11650	fant855	Enhatls3382	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	23999	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	24000	hg19	N/A	enh11650	fant856	Enhatls3382	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	1937				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3044	chr1	26448604	26457536	26122113	26131045	24001	hg19	N/A	enh11650	N/A	Enhatls3382	enhancer	E_26				TTGGAGTAGCAGATGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	indirect	Non Significant	NA					PDIK1L	chr1	26111164	26125555	2275				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3043
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24002	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CTGTGGACCAAGTTTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24003	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CTGTGGACCAAGTTTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24004	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				TCAACCTGAACCTTGGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24005	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				TCAACCTGAACCTTGGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24006	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CAGGGGTTCAGGTTGTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24007	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CAGGGGTTCAGGTTGTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24008	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CCGGCGTTGGAATGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24009	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CCGGCGTTGGAATGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24010	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CTCCACCTACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24011	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CTCCACCTACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24012	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				GTGGGGGCGGGATACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24013	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				GTGGGGGCGGGATACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24014	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				GACTCCCGATTGGCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24015	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				GACTCCCGATTGGCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24016	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				GCCGTTAGAGGAGCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24017	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				GCCGTTAGAGGAGCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24018	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				ACTAGGACTGAGGCTCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24019	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				ACTAGGACTGAGGCTCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24020	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CTCTCCCCGGCCCCTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24021	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CTCTCCCCGGCCCCTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24022	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				ACGCGAGAGGGCGTATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24023	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				ACGCGAGAGGGCGTATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24024	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				CTCGCTGTGTCCCTGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24025	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				CTCGCTGTGTCCCTGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24026	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				TCTACCCTCACTGCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24027	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				TCTACCCTCACTGCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24028	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				ACAGAAGGCGCGGATCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24029	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				ACAGAAGGCGCGGATCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24030	hg19	N/A	enh160	N/A	N/A	enhancer	E_27				GGGACGGAAAGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3067	chr1	26559628	26564626	26233137	26238135	24031	hg19	N/A	enh160	N/A	Enhatls3404	enhancer	E_27				GGGACGGAAAGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARID1A	direct	Highly Significant	NA					CEP85	chr1	26234199	26278808	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3066
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24032	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGTGCTACCTAGGAAAATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24033	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				TGTGCTACCTAGGAAAATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24034	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGTGCTACCTAGGAAAATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24035	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				AACTTGGTGAACGAGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24036	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				AACTTGGTGAACGAGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24037	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				AACTTGGTGAACGAGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24038	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GAACTGACAGGCATTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24039	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				GAACTGACAGGCATTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24040	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GAACTGACAGGCATTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24041	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCAAACGCCGAGATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24042	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				GCCAAACGCCGAGATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24043	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCAAACGCCGAGATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24044	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCAGCAGACGCGCACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24045	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				GCCAGCAGACGCGCACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24046	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCAGCAGACGCGCACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24047	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				CCGGGATGGCGCTTGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24048	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				CCGGGATGGCGCTTGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24049	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				CCGGGATGGCGCTTGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24050	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				CTGCGGCGGGAGGCCGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24051	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				CTGCGGCGGGAGGCCGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24052	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				CTGCGGCGGGAGGCCGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24053	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				ACCGGGCCGAGCAGCGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24054	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				ACCGGGCCGAGCAGCGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24055	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				ACCGGGCCGAGCAGCGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24056	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GTACCAGCAGATCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24057	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				GTACCAGCAGATCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24058	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GTACCAGCAGATCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24059	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCCGGAGTCGGGGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24060	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				GCCCGGAGTCGGGGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24061	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				GCCCGGAGTCGGGGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24062	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				AACACCTCCCACTTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24063	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				AACACCTCCCACTTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24064	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				AACACCTCCCACTTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24065	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGAGCGCGAAGACGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24066	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				TGAGCGCGAAGACGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24067	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGAGCGCGAAGACGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24068	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				ACGGAGTGCCCAGCAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24069	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				ACGGAGTGCCCAGCAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24070	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				ACGGAGTGCCCAGCAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24071	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGGGGCATCTGGCGGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24072	hg19	N/A	N/A	fant889	Enhatls3514	enhancer	E_28				TGGGGCATCTGGCGGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3164	chr1	27151255	27155432	26824764	26828941	24073	hg19	N/A	N/A	N/A	Enhatls3514	enhancer	E_28				TGGGGCATCTGGCGGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					ZDHHC18	chr1	26826687	26857604	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3163
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24074	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				CCTCTAGGCCCAGCGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24075	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				CCTCTAGGCCCAGCGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24076	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				CCTCTAGGCCCAGCGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24077	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				CTCTTACCAGCCGGGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24078	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				CTCTTACCAGCCGGGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24079	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				CTCTTACCAGCCGGGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24080	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GGTATTGTGGGTTTGATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24081	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				GGTATTGTGGGTTTGATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24082	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GGTATTGTGGGTTTGATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24083	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GCAGCAATCAGGGCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24084	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				GCAGCAATCAGGGCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24085	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GCAGCAATCAGGGCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24086	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TGGGAGACAGATCCTTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24087	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				TGGGAGACAGATCCTTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24088	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TGGGAGACAGATCCTTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24089	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TCCATTACCCCATGTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24090	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				TCCATTACCCCATGTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24091	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TCCATTACCCCATGTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24092	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GTTAGTTACTTTATGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24093	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				GTTAGTTACTTTATGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24094	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GTTAGTTACTTTATGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24095	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TAGTGACAAAGACTGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24096	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				TAGTGACAAAGACTGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24097	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				TAGTGACAAAGACTGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24098	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GCAAGGCTGGAGATTCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24099	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				GCAAGGCTGGAGATTCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24100	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				GCAAGGCTGGAGATTCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24101	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				AGCCCCATCTGCCCTGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24102	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				AGCCCCATCTGCCCTGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24103	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				AGCCCCATCTGCCCTGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24104	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				AGTCTCTTCTGCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24105	hg19	N/A	N/A	fant903	Enhatls3545	enhancer	E_30				AGTCTCTTCTGCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	10671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3192	chr1	27413941	27415388	27087450	27088897	24106	hg19	N/A	N/A	N/A	Enhatls3545	enhancer	E_30				AGTCTCTTCTGCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	direct	Highly Significant	NA					SLC9A1	chr1	27098808	27166981	9829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24107	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24108	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24109	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24110	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24111	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24112	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24113	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24114	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24115	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24116	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24117	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24118	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24119	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24120	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24121	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24122	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGTGGTGACTAGAAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24123	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24124	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24125	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24126	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24127	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24128	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24129	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24130	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24131	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24132	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24133	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24134	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24135	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24136	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24137	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24138	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				AAGGGGACACCTAGTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24139	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24140	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24141	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24142	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24143	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24144	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24145	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24146	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24147	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24148	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24149	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24150	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24151	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24152	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24153	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24154	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				CCCGCCCCCTGGGGCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24155	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24156	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24157	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24158	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24159	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24160	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24161	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24162	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24163	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24164	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24165	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24166	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24167	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24168	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24169	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24170	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGTGGGCGAGGGTTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24171	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24172	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24173	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24174	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24175	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24176	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24177	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24178	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24179	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24180	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24181	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24182	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24183	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24184	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24185	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24186	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GTGGGCGCCACCGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24187	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24188	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24189	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24190	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24191	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24192	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24193	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24194	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24195	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24196	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24197	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24198	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24199	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24200	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24201	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24202	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGAGTCCTCCGGGAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24203	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24204	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24205	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24206	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24207	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24208	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24209	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24210	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24211	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24212	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24213	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24214	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24215	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24216	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24217	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24218	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				TCCAGCAGCAACTTTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24219	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24220	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24221	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24222	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24223	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24224	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24225	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24226	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24227	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24228	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24229	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24230	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24231	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24232	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24233	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24234	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GTGGGAGTGATGTGCACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24235	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24236	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24237	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24238	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24239	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24240	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24241	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24242	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24243	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24244	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24245	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24246	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24247	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24248	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24249	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24250	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				TGGTACGGTGTATGCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24251	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24252	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24253	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24254	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24255	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24256	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24257	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24258	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24259	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24260	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24261	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24262	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24263	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24264	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24265	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24266	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				ACTGGATGTCATGTGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24267	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24268	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24269	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24270	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24271	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24272	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24273	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24274	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24275	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24276	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24277	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24278	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24279	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24280	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24281	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24282	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				ACTGGGCTGGGGAGCGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24283	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24284	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24285	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24286	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24287	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24288	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24289	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24290	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24291	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24292	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24293	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24294	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24295	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24296	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24297	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24298	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GCTCTGTCCTTCCGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24299	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24300	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24301	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24302	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24303	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24304	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24305	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24306	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24307	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24308	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24309	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24310	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24311	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24312	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24313	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24314	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GTGCCCTGTACATTTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24315	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24316	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24317	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24318	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24319	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24320	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24321	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24322	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24323	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24324	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24325	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24326	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24327	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24328	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24329	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24330	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGAGTCTCCTGGGATTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24331	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24332	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24333	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24334	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24335	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24336	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24337	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24338	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24339	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24340	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24341	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24342	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24343	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24344	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24345	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24346	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGAATGCTCCTTTGGAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24347	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24348	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24349	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24350	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24351	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24352	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24353	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24354	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24355	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24356	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24357	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24358	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24359	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24360	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24361	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24362	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGAGTTGCCTCTGCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24363	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24364	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24365	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24366	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24367	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24368	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24369	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24370	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24371	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24372	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24373	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24374	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24375	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24376	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24377	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24378	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GCTAACCTGGGCCAGGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24379	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24380	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24381	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24382	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24383	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24384	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24385	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24386	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24387	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24388	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24389	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24390	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24391	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24392	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24393	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24394	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				TGGGTAGCCCAGGTATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24395	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24396	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24397	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24398	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24399	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24400	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24401	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24402	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24403	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24404	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24405	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24406	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24407	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24408	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24409	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24410	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GCAGCCGGTAAGCCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24411	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24412	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24413	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24414	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24415	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24416	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24417	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24418	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24419	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24420	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24421	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24422	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24423	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24424	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24425	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24426	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				ACACTGAGCAAACTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24427	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24428	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24429	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24430	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24431	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24432	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24433	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24434	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24435	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24436	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24437	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24438	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24439	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24440	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24441	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24442	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GGTACTGCCCTTAACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24443	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24444	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24445	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24446	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24447	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24448	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24449	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24450	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24451	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24452	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24453	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24454	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24455	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24456	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24457	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24458	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				AGGTCTTGTGAGGAGCTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24459	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24460	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24461	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24462	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24463	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24464	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24465	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24466	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24467	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24468	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24469	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24470	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24471	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24472	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24473	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24474	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				CAGGGCCGGCCTAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24475	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24476	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24477	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24478	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24479	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24480	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24481	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24482	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24483	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24484	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24485	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24486	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24487	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24488	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24489	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24490	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GAGCGGTGCCCGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24491	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24492	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24493	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24494	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24495	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24496	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24497	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24498	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24499	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24500	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24501	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24502	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24503	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24504	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24505	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24506	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GAGTGATGTCGCTAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24507	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24508	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24509	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24510	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24511	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24512	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24513	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24514	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24515	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24516	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24517	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24518	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24519	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24520	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24521	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24522	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				CCTCCCGGGCACCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24523	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24524	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24525	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24526	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24527	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24528	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24529	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24530	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24531	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24532	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24533	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24534	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24535	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24536	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24537	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24538	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				CCGGGGCGCTCTTCGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24539	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24540	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24541	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24542	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24543	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24544	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24545	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24546	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24547	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24548	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24549	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24550	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24551	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24552	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24553	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24554	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				TGGGGCTGGACGCGTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24555	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24556	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24557	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24558	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24559	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24560	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24561	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24562	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24563	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24564	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24565	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24566	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24567	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24568	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24569	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24570	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				ATACCTACAGCCGCACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24571	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24572	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24573	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24574	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24575	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24576	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24577	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24578	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24579	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24580	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24581	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24582	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24583	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24584	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24585	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24586	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GTATGTGGCAAGTGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24587	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24588	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24589	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24590	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24591	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24592	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24593	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24594	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24595	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24596	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24597	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24598	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24599	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24600	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24601	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24602	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				TGACTGCGTCAGTGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24603	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24604	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24605	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24606	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24607	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24608	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24609	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24610	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24611	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24612	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24613	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24614	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24615	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24616	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24617	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24618	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				GTAACCTTAACAAGCCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24619	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24620	hg19	N/A	enh11668	fant929	Enhatls3643	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24621	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24622	hg19	N/A	enh11668	fant930	Enhatls3643	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24623	hg19	N/A	enh11668	N/A	Enhatls3643	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24624	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24625	hg19	N/A	enh11668	N/A	Enhatls3644	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24626	hg19	N/A	enh11668	N/A	N/A	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24627	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24628	hg19	N/A	enh11668	fant931	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24629	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24630	hg19	N/A	enh11668	fant932	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24631	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24632	hg19	N/A	enh11668	fant933	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24633	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3280	chr1	27880089	27901538	27553578	27575027	24634	hg19	N/A	enh11668	fant934	Enhatls3645	enhancer	E_33				CACCATGTAGGGTGATGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"FGR,ARID1A"	indirect	Non Significant	NA					AHDC1	chr1	27534034	27604177	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3279
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24635	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GGACTGGCTAGGGTTAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24636	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GGACTGGCTAGGGTTAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24637	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				AGATCCCTGGCAACACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24638	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				AGATCCCTGGCAACACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24639	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				AAGTTTGCAGCATTCACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24640	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				AAGTTTGCAGCATTCACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24641	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GAGTTTCCCCCGCCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24642	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GAGTTTCCCCCGCCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24643	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				TGTCAGAGCCCGGCGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24644	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				TGTCAGAGCCCGGCGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24645	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				ACGGCCTCGGAAGTCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24646	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				ACGGCCTCGGAAGTCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24647	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CGTTCCCGAAGCCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24648	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CGTTCCCGAAGCCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24649	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CGGGGAGCTTCTAGAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24650	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CGGGGAGCTTCTAGAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24651	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GCACCCGAGTGGGTTTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24652	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GCACCCGAGTGGGTTTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24653	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GGCGCGCACCATGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24654	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GGCGCGCACCATGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24655	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CGAGTCGCCGACGCCGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24656	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CGAGTCGCCGACGCCGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24657	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GACAGCCTGAGGCTCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24658	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GACAGCCTGAGGCTCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24659	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GTTGCATCAACTGGCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24660	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GTTGCATCAACTGGCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24661	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CCAGGAGTCCGAGGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24662	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CCAGGAGTCCGAGGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24663	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				TCCTGAGCGTCTTCAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24664	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				TCCTGAGCGTCTTCAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24665	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GCGAAGAGGAAGGGACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24666	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GCGAAGAGGAAGGGACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24667	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CAGGTGCCTACGCCCCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24668	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CAGGTGCCTACGCCCCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24669	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GCGGGCCGCCCGGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24670	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GCGGGCCGCCCGGTACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24671	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				CGGCTTCCGAAGCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24672	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				CGGCTTCCGAAGCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24673	hg19	N/A	N/A	N/A	Enhatls3744	enhancer	E_36				GCCGGGATGCGAATGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3377	chr1	28585459	28588228	28258948	28261717	24674	hg19	N/A	enh49693	N/A	Enhatls3744	enhancer	E_36				GCCGGGATGCGAATGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGR	direct	Highly Significant	NA					SESN2	chr1	28259517	28282491	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3376
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24675	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				GAGGCAATGACCACGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24676	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				GGTATGTTGTGAACCGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24677	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				TATGAGTGCCTGAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24678	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				TCTGAACAAGTAGTTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24679	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				GCTGGTACAAAGAGAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24680	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				TGATAGCGGTCAGACCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24681	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				ACTGGGGGAAGACGGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3571	chr1	31767450	31774168	31294603	31301321	24682	hg19	N/A	N/A	fant1073	N/A	enhancer	E_38				GGATTACTGCATATCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3570
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24683	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				AACTGCTTCCTTTAAGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24684	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				AGCATTACTACTCTGCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24685	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				GATGGCTACTATGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24686	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				AGTGACTAGTGTATGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24687	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				CATTTGGTGTTTTTGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24688	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				CTACTGTACTGTTATATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24689	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				CGCTTGAGCCAAGGAGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24690	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				TAGGCTGGTGTCACCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3572	chr1	31778551	31781147	31305704	31308300	24691	hg19	N/A	enh26609	N/A	Enhatls3951	enhancer	E_39				CACCAGGCTAGACTATAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZCCHC17	chr1	31296981	31364953	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3571
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24692	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				AACCAAGTCTTATGGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24693	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				AGGTTCCGAGGAGATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24694	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GTTCTTCTCGGAGCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24695	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GCCGAGCTAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24696	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GACAGAGCTGGCACTTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24697	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				CGTCCCTCCCCCTCTTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24698	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				AGCGAAGGCCCTCCTGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24699	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				ATTGCACCTCCACTGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24700	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				CCCAAGCTAGTAGCTAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24701	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				AAGGGTTGACTTCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24702	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GATTACTACAGCAAGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24703	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GGAAGCCTCTATGACTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24704	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GCAATATAAAACCCTTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24705	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				TGGCTAGGGCATCCATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24706	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GGATGCCAAGGGAGGGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24707	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GGTGTTGACCCGTGAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24708	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GACGGCTTGACTCAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24709	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GGGTAGCAAGCAGTGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24710	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				CAGGGCTTTCTCCCTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24711	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				CTGGTACAACCACAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24712	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				TGATGGCATGAATTAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24713	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				ATAAAATTTAGGCATTCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3583	chr1	31866937	31871351	31394090	31398504	24714	hg19	N/A	enh11712	N/A	Enhatls3964	enhancer	E_40				GGACTGACCCTGAGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					SERINC2	chr1	31409564	31434680	6892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3582
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24715	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GTGACTTCCATCTTGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24716	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GTGACTTCCATCTTGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24717	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GTGACTTCCATCTTGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24718	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GTGACTTCCATCTTGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24719	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CCCGGAAGATGATCAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24720	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CCCGGAAGATGATCAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24721	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CCCGGAAGATGATCAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24722	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CCCGGAAGATGATCAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24723	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CGCAACCGCGACTTCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24724	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CGCAACCGCGACTTCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24725	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CGCAACCGCGACTTCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24726	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CGCAACCGCGACTTCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24727	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				TTGGCTGTCACTGAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24728	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				TTGGCTGTCACTGAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24729	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				TTGGCTGTCACTGAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24730	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				TTGGCTGTCACTGAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24731	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CCCGGCTCAGGGGCAGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24732	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CCCGGCTCAGGGGCAGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24733	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CCCGGCTCAGGGGCAGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24734	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CCCGGCTCAGGGGCAGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24735	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CCTCAGGCTCCACGGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24736	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CCTCAGGCTCCACGGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24737	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CCTCAGGCTCCACGGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24738	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CCTCAGGCTCCACGGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24739	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GGACGTGACCAGGAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24740	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GGACGTGACCAGGAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24741	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GGACGTGACCAGGAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24742	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GGACGTGACCAGGAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24743	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				ACAGAACATGGTACACGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24744	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				ACAGAACATGGTACACGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24745	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				ACAGAACATGGTACACGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24746	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				ACAGAACATGGTACACGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24747	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				ATAGAATGTTAGGGCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24748	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				ATAGAATGTTAGGGCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24749	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				ATAGAATGTTAGGGCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24750	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				ATAGAATGTTAGGGCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24751	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				TCATGGAGCGCCTGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24752	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				TCATGGAGCGCCTGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24753	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				TCATGGAGCGCCTGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24754	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				TCATGGAGCGCCTGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24755	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GTCAGAAAAGGAGACCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24756	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GTCAGAAAAGGAGACCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24757	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GTCAGAAAAGGAGACCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24758	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GTCAGAAAAGGAGACCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24759	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CCGACCATCCAACCATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24760	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CCGACCATCCAACCATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24761	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CCGACCATCCAACCATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24762	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CCGACCATCCAACCATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24763	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GCGATGACAGGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24764	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GCGATGACAGGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24765	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GCGATGACAGGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24766	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GCGATGACAGGGCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24767	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GTCAGGGCAGGTACCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24768	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GTCAGGGCAGGTACCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24769	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GTCAGGGCAGGTACCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24770	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GTCAGGGCAGGTACCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24771	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				CCAGGCCTCGGGGTGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24772	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				CCAGGCCTCGGGGTGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24773	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				CCAGGCCTCGGGGTGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24774	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				CCAGGCCTCGGGGTGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24775	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				TCCGTACCACGGCAGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24776	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				TCCGTACCACGGCAGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24777	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				TCCGTACCACGGCAGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24778	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				TCCGTACCACGGCAGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3591	chr1	31905140	31912503	31432293	31439656	24779	hg19	N/A	N/A	N/A	Enhatls3972	enhancer	E_41				GGAACAATGCCACCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3590
enhrx-3592	chr1	31905140	31912503	31432293	31439656	24780	hg19	N/A	N/A	N/A	Enhatls3973	enhancer	E_41				GGAACAATGCCACCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3591
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24781	hg19	N/A	N/A	N/A	Enhatls3974	enhancer	E_41				GGAACAATGCCACCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3593	chr1	31905140	31912503	31432293	31439656	24782	hg19	N/A	enh197	N/A	Enhatls3974	enhancer	E_41				GGAACAATGCCACCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SERINC2	chr1	31409564	31434680	659				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24783	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				CTCAGCCACATGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24784	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				CTCAGCCACATGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24785	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				CTCAGCCACATGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24786	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				CTCAGCCACATGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24787	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				GCGTGGCTTGGAGTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24788	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GCGTGGCTTGGAGTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24789	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				GCGTGGCTTGGAGTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24790	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GCGTGGCTTGGAGTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24791	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				GGAGCATTATGAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24792	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GGAGCATTATGAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24793	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				GGAGCATTATGAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24794	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GGAGCATTATGAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24795	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				GAGACTTGCATGCCTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24796	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GAGACTTGCATGCCTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24797	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				GAGACTTGCATGCCTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24798	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GAGACTTGCATGCCTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24799	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				GACAAAGCCTGGCCCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24800	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GACAAAGCCTGGCCCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24801	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				GACAAAGCCTGGCCCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24802	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GACAAAGCCTGGCCCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24803	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				ACCGTGAGCAAATCCTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24804	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ACCGTGAGCAAATCCTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24805	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				ACCGTGAGCAAATCCTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24806	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ACCGTGAGCAAATCCTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24807	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				TTTGACAAATCAGACAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24808	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TTTGACAAATCAGACAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24809	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				TTTGACAAATCAGACAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24810	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TTTGACAAATCAGACAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24811	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				AACAACTGAATAGATGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24812	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AACAACTGAATAGATGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24813	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				AACAACTGAATAGATGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24814	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AACAACTGAATAGATGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24815	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				CTAGGTGCTGGGGCTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24816	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				CTAGGTGCTGGGGCTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24817	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				CTAGGTGCTGGGGCTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24818	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				CTAGGTGCTGGGGCTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24819	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				ATAGCTGACATGCCCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24820	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGCTGACATGCCCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24821	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				ATAGCTGACATGCCCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24822	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGCTGACATGCCCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24823	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				TGAAAGATGGCGATGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24824	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TGAAAGATGGCGATGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24825	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				TGAAAGATGGCGATGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24826	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TGAAAGATGGCGATGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24827	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				GGGACGGGGAAAGACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24828	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GGGACGGGGAAAGACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24829	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				GGGACGGGGAAAGACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24830	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				GGGACGGGGAAAGACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24831	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				AACACAGGCGGCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24832	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AACACAGGCGGCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24833	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				AACACAGGCGGCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24834	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AACACAGGCGGCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24835	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				TCAGCTATCTGGGGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24836	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TCAGCTATCTGGGGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24837	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				TCAGCTATCTGGGGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24838	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TCAGCTATCTGGGGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24839	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				ATAGTTTTTCCTGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24840	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGTTTTTCCTGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24841	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				ATAGTTTTTCCTGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24842	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGTTTTTCCTGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24843	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				AGCCTTTGACACAGCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24844	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AGCCTTTGACACAGCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24845	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				AGCCTTTGACACAGCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24846	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				AGCCTTTGACACAGCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24847	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				TGGCACAGGGAAGGTAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24848	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TGGCACAGGGAAGGTAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24849	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				TGGCACAGGGAAGGTAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24850	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				TGGCACAGGGAAGGTAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24851	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				ATTTCTTGAACACTACTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24852	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATTTCTTGAACACTACTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24853	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				ATTTCTTGAACACTACTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24854	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATTTCTTGAACACTACTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24855	hg19	N/A	enh199	fant1081	Enhatls3980	enhancer	E_42				ATAGCATTTGAGTAACATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27737				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24856	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGCATTTGAGTAACATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	27035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24857	hg19	N/A	enh199	fant1082	Enhatls3980	enhancer	E_42				ATAGCATTTGAGTAACATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	26496				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32014277	32015828	31548676	31550227	24858	hg19	N/A	enh199	N/A	Enhatls3980	enhancer	E_42				ATAGCATTTGAGTAACATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	22971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24859	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24860	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24861	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24862	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24863	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24864	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24865	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24866	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24867	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24868	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24869	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24870	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24871	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24872	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24873	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24874	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24875	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24876	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24877	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24878	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24879	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24880	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATGACATTTACCAATACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24881	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24882	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24883	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24884	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24885	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24886	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24887	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24888	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24889	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24890	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24891	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24892	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24893	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24894	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24895	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24896	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24897	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24898	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24899	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24900	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24901	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24902	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGTAGTGGGTGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24903	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24904	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24905	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24906	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24907	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24908	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24909	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24910	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24911	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24912	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24913	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24914	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24915	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24916	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24917	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24918	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24919	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24920	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24921	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24922	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24923	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24924	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GACCTGGGAGGACAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24925	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24926	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24927	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24928	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24929	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24930	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24931	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24932	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24933	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24934	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24935	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24936	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24937	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24938	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24939	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24940	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24941	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24942	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24943	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24944	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24945	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24946	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGTGGAGGGATAATATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24947	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24948	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24949	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24950	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24951	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24952	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24953	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24954	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24955	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24956	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24957	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24958	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24959	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24960	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24961	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24962	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24963	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24964	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24965	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24966	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24967	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24968	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CTTGGTGACTCACCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24969	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24970	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24971	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24972	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24973	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24974	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24975	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24976	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24977	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24978	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24979	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24980	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24981	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24982	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24983	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24984	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24985	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24986	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24987	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24988	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24989	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24990	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TTTGGGGGAGGTTTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24991	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	24992	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24993	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24994	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	24995	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24996	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24997	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24998	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	24999	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25000	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25001	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25002	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25003	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25004	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25005	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25006	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25007	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25008	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25009	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25010	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25011	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25012	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAGGGCGTTGCACAATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25013	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25014	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25015	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25016	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25017	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25018	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25019	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25020	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25021	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25022	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25023	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25024	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25025	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25026	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25027	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25028	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25029	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25030	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25031	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25032	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25033	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25034	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AAGGCAAGGGCCCTACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25035	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25036	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25037	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25038	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25039	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25040	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25041	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25042	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25043	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25044	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25045	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25046	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25047	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25048	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25049	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25050	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25051	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25052	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25053	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25054	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25055	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25056	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GCCCTCTCTAGCAAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25057	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25058	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25059	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25060	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25061	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25062	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25063	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25064	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25065	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25066	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25067	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25068	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25069	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25070	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25071	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25072	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25073	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25074	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25075	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25076	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25077	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25078	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				AGGGAAGGCAGACTCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25079	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25080	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25081	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25082	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25083	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25084	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25085	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25086	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25087	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25088	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25089	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25090	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25091	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25092	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25093	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25094	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25095	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25096	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25097	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25098	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25099	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25100	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGCCCTGGGCGGCTCATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25101	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25102	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25103	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25104	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25105	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25106	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25107	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25108	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25109	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25110	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25111	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25112	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25113	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25114	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25115	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25116	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25117	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25118	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25119	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25120	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25121	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25122	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GGGGGGCGGCACCCAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25123	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25124	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25125	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25126	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25127	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25128	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25129	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25130	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25131	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25132	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25133	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25134	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25135	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25136	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25137	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25138	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25139	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25140	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25141	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25142	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25143	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25144	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TATTACCGAGGGGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25145	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25146	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25147	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25148	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25149	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25150	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25151	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25152	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25153	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25154	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25155	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25156	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25157	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25158	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25159	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25160	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25161	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25162	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25163	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25164	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25165	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25166	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TGTGTCCATAACCCAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25167	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25168	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25169	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25170	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25171	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25172	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25173	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25174	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25175	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25176	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25177	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25178	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25179	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25180	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25181	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25182	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25183	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25184	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25185	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25186	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25187	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25188	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GAAGGATTGCGGTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25189	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25190	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25191	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25192	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25193	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25194	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25195	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25196	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25197	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25198	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25199	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25200	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25201	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25202	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25203	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25204	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25205	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25206	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25207	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25208	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25209	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25210	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				GTAACTACCCCACAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25211	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25212	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25213	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25214	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25215	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25216	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25217	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25218	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25219	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25220	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25221	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25222	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25223	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25224	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25225	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25226	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25227	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25228	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25229	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25230	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25231	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25232	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				CCACTGCTGGGGCGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25233	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25234	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25235	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25236	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25237	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25238	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25239	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25240	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25241	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25242	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25243	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25244	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25245	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25246	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25247	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25248	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25249	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25250	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25251	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25252	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25253	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25254	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				TCTTGACTTTGAGCGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25255	hg19	N/A	enh11716	N/A	Enhatls3980	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	5051				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3594	chr1	32033367	32051409	31567766	31585808	25256	hg19	N/A	N/A	N/A	Enhatls3980	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	4996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3593
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25257	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25258	hg19	N/A	enh98442	N/A	Enhatls3981	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	382				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3595	chr1	32033367	32051409	31567766	31585808	25259	hg19	N/A	enh98442	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3594
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25260	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25261	hg19	N/A	enh11717	N/A	Enhatls3982	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25262	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25263	hg19	N/A	enh11717	N/A	Enhatls3983	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25264	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25265	hg19	N/A	enh11717	N/A	Enhatls3984	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25266	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25267	hg19	N/A	enh11717	N/A	Enhatls3985	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25268	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25269	hg19	N/A	enh11717	N/A	Enhatls3986	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25270	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25271	hg19	N/A	enh11717	N/A	Enhatls3987	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25272	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25273	hg19	N/A	enh11717	N/A	Enhatls3988	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25274	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25275	hg19	N/A	enh11717	N/A	Enhatls3989	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3596	chr1	32033367	32051409	31567766	31585808	25276	hg19	N/A	enh11717	N/A	N/A	enhancer	E_43				ACGCTCCCCTGCTCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TINAGL1	chr1	31576484	31587686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3595
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25277	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				CGTTCTCATTGTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25278	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				CGTTCTCATTGTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25279	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				TGACTCCTGGATTTTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25280	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				TGACTCCTGGATTTTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25281	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				GAAGGATGAAGCGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25282	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				GAAGGATGAAGCGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25283	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				CATCTCCTGGACCGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25284	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				CATCTCCTGGACCGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25285	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				GCTGGTGAAGAGACTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25286	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				GCTGGTGAAGAGACTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25287	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				GCGCAGGCACCGCCTCCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25288	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				GCGCAGGCACCGCCTCCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25289	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				ATGCAAATGTAGCGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25290	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				ATGCAAATGTAGCGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25291	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				CAATATGTCGGAGGCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25292	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				CAATATGTCGGAGGCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25293	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				GCGAAGCGGAGAGCACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25294	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				GCGAAGCGGAGAGCACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25295	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				CTGCTAATTGCTGCTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25296	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				CTGCTAATTGCTGCTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25297	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				CACCCCGCAAAACGACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25298	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				CACCCCGCAAAACGACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25299	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				TGTGGGGGCGGGACATTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25300	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				TGTGGGGGCGGGACATTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25301	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				TCGTGAGGACCAGCTCGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25302	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				TCGTGAGGACCAGCTCGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25303	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				GCGGGGAGACTTCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25304	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				GCGGGGAGACTTCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3730	chr1	32533867	32541298	32068266	32075697	25305	hg19	N/A	N/A	N/A	Enhatls4132	enhancer	E_44				AGGCGGAGCTTCTGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3729
enhrx-3731	chr1	32533867	32541298	32068266	32075697	25306	hg19	N/A	N/A	N/A	Enhatls4133	enhancer	E_44				AGGCGGAGCTTCTGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					TMEM39B	chr1	32072934	32102863	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3730
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25307	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25308	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25309	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25310	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25311	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25312	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGATACATGATATTTTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25313	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25314	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25315	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25316	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25317	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25318	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTATAGTATGTCGTACTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25319	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25320	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25321	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25322	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25323	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25324	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CATATTTTGATGGGAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25325	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25326	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25327	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25328	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25329	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25330	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTCACTCTTGTTGCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25331	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25332	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25333	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25334	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25335	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25336	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTGATCTCGGCCTGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25337	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25338	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25339	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25340	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25341	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25342	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GAGGCACGGTTTCCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25343	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25344	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25345	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25346	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25347	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25348	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATCAATGAGTGAAGATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25349	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25350	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25351	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25352	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25353	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25354	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TACACACTGCAGGATCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25355	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25356	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25357	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25358	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25359	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25360	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAGTTATAACACGGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25361	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25362	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25363	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25364	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25365	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25366	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGGTACTCTGAGAACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25367	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25368	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25369	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25370	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25371	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25372	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CACTGGACTTTTTGTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25373	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25374	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25375	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25376	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25377	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25378	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCTCATGGTGCCGGTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25379	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25380	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25381	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25382	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25383	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25384	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGACGCCCGTAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25385	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25386	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25387	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25388	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25389	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25390	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GATTGCCGCTGCGCGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25391	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25392	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25393	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25394	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25395	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25396	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCAACCAGCCTGGTAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25397	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25398	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25399	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25400	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25401	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25402	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				CCTCGCTCTCGGCCGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25403	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25404	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25405	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25406	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25407	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25408	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTTGGGAACGGCCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25409	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25410	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25411	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25412	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25413	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25414	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GCCTCTCCTGCGCGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25415	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25416	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25417	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25418	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25419	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25420	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25421	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25422	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25423	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25424	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25425	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25426	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GTGTCTGGAGCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25427	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25428	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25429	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25430	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25431	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25432	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				GGGAAGTTCTGCAAATTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25433	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25434	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25435	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25436	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25437	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25438	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TTTGTCTGTCTCATCTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25439	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25440	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25441	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25442	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25443	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25444	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TCTCAACGCAGCACGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25445	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25446	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25447	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25448	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25449	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25450	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				AAGTGAGTGTGACCTTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25451	hg19	N/A	N/A	N/A	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25452	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25453	hg19	N/A	enh89476	fant1112	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	560				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25454	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25455	hg19	N/A	enh89476	fant1113	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	3710				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3802	chr1	32956440	32967644	32490839	32502043	25456	hg19	N/A	enh89476	N/A	Enhatls4215	enhancer	E_47				TATAATAACAGTATTTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	indirect	Non Significant	NA					ZBTB8B	chr1	32465071	32496686	4495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25457	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				ATGTACTTATACAGTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25458	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				ATGTACTTATACAGTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25459	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				ATGTACTTATACAGTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25460	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TTGGGAAAGGCGCCTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25461	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				TTGGGAAAGGCGCCTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25462	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TTGGGAAAGGCGCCTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25463	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CGTGCAGCGAGTGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25464	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				CGTGCAGCGAGTGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25465	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CGTGCAGCGAGTGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25466	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GTATTTGCTGACGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25467	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				GTATTTGCTGACGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25468	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GTATTTGCTGACGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25469	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CCGGTCGCGCGCGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25470	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				CCGGTCGCGCGCGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25471	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CCGGTCGCGCGCGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25472	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TAAGTGGCTGCACGCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25473	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				TAAGTGGCTGCACGCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25474	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TAAGTGGCTGCACGCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25475	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GGCTCTGACGGCCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25476	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				GGCTCTGACGGCCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25477	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GGCTCTGACGGCCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25478	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GAGCGCGGCGGGAGGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25479	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				GAGCGCGGCGGGAGGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25480	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GAGCGCGGCGGGAGGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25481	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25482	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25483	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				AGGCGCGCGGAGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25484	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CCAGAGTCCGCGGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25485	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				CCAGAGTCCGCGGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25486	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CCAGAGTCCGCGGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25487	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GCAAAGACGGGCGGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25488	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				GCAAAGACGGGCGGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25489	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GCAAAGACGGGCGGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25490	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GTCTCTGCGGGCGCGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25491	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				GTCTCTGCGGGCGCGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25492	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				GTCTCTGCGGGCGCGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25493	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CGCATCTTGACATAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25494	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				CGCATCTTGACATAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25495	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				CGCATCTTGACATAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25496	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TGACTAACTCACAAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25497	hg19	N/A	N/A	fant1114	Enhatls4216	enhancer	E_48				TGACTAACTCACAAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3803	chr1	33004167	33006932	32538566	32541331	25498	hg19	N/A	N/A	N/A	Enhatls4216	enhancer	E_48				TGACTAACTCACAAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					ZBTB8A	chr1	32539426	32605941	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25499	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				ACATTTGCAGGGAGGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25500	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				ACATTTGCAGGGAGGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25501	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				TGGGCCAAATGGCACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25502	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				TGGGCCAAATGGCACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25503	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				ATTTTCATGTAGTCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25504	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				ATTTTCATGTAGTCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25505	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GCACTGGAGCCGCCTCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25506	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GCACTGGAGCCGCCTCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25507	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				AGACAGGCGAAAGACGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25508	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				AGACAGGCGAAAGACGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25509	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GGGCCCGGCTATTAATAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25510	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GGGCCCGGCTATTAATAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25511	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GATCCGGTGTCGGTTGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25512	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GATCCGGTGTCGGTTGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25513	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CGGGCGCGCCCACTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25514	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CGGGCGCGCCCACTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25515	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				AGGTTTGGAAAGACAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25516	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				AGGTTTGGAAAGACAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25517	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				TCGTGAGGTCCCGTTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25518	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				TCGTGAGGTCCCGTTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25519	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CCTCTGGTCCCCACCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25520	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CCTCTGGTCCCCACCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25521	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GGCAGCTGTCGTGAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25522	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GGCAGCTGTCGTGAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25523	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GGGGTTAGAGAGAACTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25524	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GGGGTTAGAGAGAACTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25525	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GGGCTGAGTGGGGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25526	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GGGCTGAGTGGGGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25527	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GGTTTGACCCTCACACTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25528	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GGTTTGACCCTCACACTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25529	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				GTCAAAGACCTCCCCAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25530	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				GTCAAAGACCTCCCCAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25531	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CCGGTGGGGGAAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25532	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CCGGTGGGGGAAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25533	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CATGGTGGAGTGTCTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25534	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CATGGTGGAGTGTCTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25535	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				ACACAGTCAGAGTCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25536	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				ACACAGTCAGAGTCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25537	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				AGGCAGCACACTCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25538	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				AGGCAGCACACTCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25539	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CCTCCCCTGGAATAGTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25540	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CCTCCCCTGGAATAGTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25541	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				TGCCCGCCAGAGGAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25542	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				TGCCCGCCAGAGGAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25543	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				TACCAAGCAACAGGCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25544	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				TACCAAGCAACAGGCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25545	hg19	N/A	enh109304	N/A	Enhatls4232	enhancer	E_49				CGGGTCAGAAATTCAGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3819	chr1	33166161	33172612	32700560	32707011	25546	hg19	N/A	N/A	N/A	Enhatls4232	enhancer	E_49				CGGGTCAGAAATTCAGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3818
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25547	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				TTTAAGCCTTTCCCAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25548	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				TTTAAGCCTTTCCCAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25549	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				TTTAAGCCTTTCCCAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25550	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GCGCTGTTGCCACATCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25551	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				GCGCTGTTGCCACATCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25552	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GCGCTGTTGCCACATCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25553	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				TAGAGGCCCCAGAGGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25554	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				TAGAGGCCCCAGAGGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25555	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				TAGAGGCCCCAGAGGACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25556	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GCCTGCTTGGCTGGAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25557	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				GCCTGCTTGGCTGGAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25558	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GCCTGCTTGGCTGGAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25559	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GTACACACTCCTGTGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25560	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				GTACACACTCCTGTGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25561	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				GTACACACTCCTGTGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25562	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				AAACGTGCACTTTGACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25563	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				AAACGTGCACTTTGACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25564	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				AAACGTGCACTTTGACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25565	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				ATACTTACTCCTGCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	5676				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25566	hg19	N/A	enh11726	fant1117	Enhatls4233	enhancer	E_50				ATACTTACTCCTGCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33182265	33184160	32716664	32718559	25567	hg19	N/A	enh11726	N/A	Enhatls4233	enhancer	E_50				ATACTTACTCCTGCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	13321				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25568	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				CCCACTGAGAGGAATAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25569	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				CCCACTGAGAGGAATAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25570	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				CCCACTGAGAGGAATAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25571	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TCAAAGTCCCAGTGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25572	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TCAAAGTCCCAGTGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25573	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TCAAAGTCCCAGTGGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25574	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				AGGGGCTCAAGCATACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25575	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				AGGGGCTCAAGCATACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25576	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				AGGGGCTCAAGCATACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25577	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TGTGCCCAGAGCATAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25578	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TGTGCCCAGAGCATAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25579	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TGTGCCCAGAGCATAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25580	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GTGATCGGCCCTACTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25581	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				GTGATCGGCCCTACTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25582	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GTGATCGGCCCTACTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25583	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCTAGTTGTTACAGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25584	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				GCTAGTTGTTACAGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25585	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCTAGTTGTTACAGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25586	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TCTTGATACCCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25587	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TCTTGATACCCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25588	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TCTTGATACCCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25589	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCAGGGAGGAGTTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25590	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				GCAGGGAGGAGTTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25591	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCAGGGAGGAGTTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25592	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				CTGGTTCCGAAAAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25593	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				CTGGTTCCGAAAAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25594	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				CTGGTTCCGAAAAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25595	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TTGGCCTGCAAGATGGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25596	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TTGGCCTGCAAGATGGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25597	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TTGGCCTGCAAGATGGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25598	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TTAGGTTGACTAGACAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25599	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TTAGGTTGACTAGACAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25600	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TTAGGTTGACTAGACAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25601	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TATGCAGGTGGGAAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25602	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				TATGCAGGTGGGAAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25603	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				TATGCAGGTGGGAAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25604	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCCCAGGAGGGCAAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					SYNC	chr1	32679905	32703596	16629				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25605	hg19	N/A	enh11727	fant1118	Enhatls4233	enhancer	E_51				GCCCAGGAGGGCAAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	16910				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3820	chr1	33189126	33196194	32723525	32730593	25606	hg19	N/A	enh11727	N/A	Enhatls4233	enhancer	E_51				GCCCAGGAGGGCAAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	5426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3819
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25607	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25608	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25609	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25610	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25611	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25612	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25613	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25614	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTGAGCTCCTGCCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25615	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25616	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25617	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25618	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25619	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25620	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25621	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25622	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TAATTGATCATGGGCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25623	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25624	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25625	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25626	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25627	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25628	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25629	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25630	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				GCTCTTACAAAAGTTCTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25631	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25632	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25633	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25634	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25635	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25636	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25637	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25638	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CCAGTAGACCGACATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25639	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25640	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25641	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25642	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25643	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25644	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25645	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25646	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				TGGGTGGATCTGGCCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25647	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25648	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25649	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25650	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25651	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25652	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25653	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25654	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				AGTGCACAGAACGTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25655	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25656	hg19	N/A	enh11728	fant1124	Enhatls4234	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25657	hg19	N/A	enh11728	N/A	Enhatls4234	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25658	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25659	hg19	N/A	enh11728	fant1125	N/A	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25660	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25661	hg19	N/A	enh11728	fant1126	N/A	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3822	chr1	33224693	33228274	32759092	32762673	25662	hg19	N/A	enh11728	N/A	N/A	enhancer	E_52				CTGCTTTGCCATTTACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					NHSL3	chr1	32741829	32774970	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3821
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25663	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25664	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25665	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25666	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25667	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25668	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25669	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25670	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25671	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25672	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25673	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25674	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25675	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25676	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25677	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25678	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25679	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25680	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25681	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25682	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25683	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25684	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25685	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25686	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25687	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATGCATCAGCATCTTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25688	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25689	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25690	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25691	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25692	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25693	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25694	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25695	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25696	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25697	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25698	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25699	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25700	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25701	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25702	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25703	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25704	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25705	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25706	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25707	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25708	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25709	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25710	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25711	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25712	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATTTCCAGCTCTTCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25713	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25714	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25715	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25716	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25717	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25718	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25719	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25720	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25721	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25722	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25723	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25724	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25725	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25726	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25727	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25728	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25729	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25730	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25731	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25732	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25733	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25734	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25735	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25736	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25737	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				AAGGAGACCTGGATTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25738	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25739	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25740	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25741	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25742	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25743	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25744	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25745	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25746	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25747	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25748	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25749	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25750	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25751	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25752	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25753	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25754	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25755	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25756	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25757	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25758	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25759	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25760	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25761	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25762	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GAGACGGAAGCCTCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25763	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25764	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25765	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25766	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25767	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25768	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25769	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25770	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25771	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25772	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25773	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25774	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25775	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25776	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25777	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25778	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25779	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25780	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25781	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25782	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25783	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25784	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25785	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25786	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25787	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTTCCTGTATTTTGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25788	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25789	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25790	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25791	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25792	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25793	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25794	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25795	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25796	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25797	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25798	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25799	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25800	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25801	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25802	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25803	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25804	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25805	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25806	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25807	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25808	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25809	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25810	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25811	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25812	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCTCAGTTACGAAGTAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25813	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25814	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25815	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25816	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25817	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25818	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25819	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25820	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25821	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25822	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25823	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25824	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25825	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25826	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25827	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25828	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25829	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25830	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25831	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25832	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25833	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25834	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25835	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25836	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25837	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				ATAGTACAGCAGGCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25838	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25839	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25840	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25841	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25842	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25843	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25844	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25845	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25846	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25847	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25848	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25849	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25850	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25851	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25852	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25853	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25854	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25855	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25856	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25857	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25858	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25859	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25860	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25861	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25862	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGCACATTAACCTTCCTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25863	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25864	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25865	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25866	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25867	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25868	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25869	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25870	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25871	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25872	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25873	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25874	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25875	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25876	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25877	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25878	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25879	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25880	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25881	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25882	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25883	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25884	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25885	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25886	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25887	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GCAAGTATGCAAGGAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25888	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25889	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25890	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25891	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25892	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25893	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25894	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25895	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25896	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25897	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25898	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25899	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25900	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25901	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25902	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25903	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25904	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25905	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25906	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25907	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25908	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25909	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25910	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25911	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25912	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TATGAACAGGCTTGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25913	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25914	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25915	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25916	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25917	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25918	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25919	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25920	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25921	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25922	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25923	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25924	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25925	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25926	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25927	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25928	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25929	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25930	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25931	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25932	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25933	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25934	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25935	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25936	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25937	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				CTGTAAAGACCTTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25938	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25939	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25940	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25941	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25942	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25943	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25944	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25945	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25946	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25947	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25948	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25949	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25950	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25951	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25952	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25953	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25954	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25955	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25956	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25957	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25958	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25959	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25960	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25961	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25962	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGGCTGATCAAGCTTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25963	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25964	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25965	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25966	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25967	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25968	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25969	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25970	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25971	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25972	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25973	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25974	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25975	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25976	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25977	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25978	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25979	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25980	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25981	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25982	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25983	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25984	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25985	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25986	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25987	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				TGCTGACTCACTCTGGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25988	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	12520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25989	hg19	N/A	enh216	fant1135	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	16407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25990	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25991	hg19	N/A	enh216	fant1136	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17258				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25992	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	17298				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25993	hg19	N/A	enh216	fant1137	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18349				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25994	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	18520				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25995	hg19	N/A	enh216	fant1138	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	19703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25996	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25997	hg19	N/A	enh216	fant1139	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					RNF19B	chr1	32936444	32964809	20190				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25998	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	25999	hg19	N/A	enh216	fant1140	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	18115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26000	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	16181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26001	hg19	N/A	enh216	fant1141	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15860				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26002	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	15675				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26003	hg19	N/A	enh216	fant1142	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26004	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26005	hg19	N/A	enh216	fant1143	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	14513				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26006	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26007	hg19	N/A	enh216	fant1144	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	13114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26008	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10456				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26009	hg19	N/A	enh216	fant1145	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	10097				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26010	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9897				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26011	hg19	N/A	enh216	fant1146	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	9702				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-3857	chr1	33445377	33464279	32979776	32998678	26012	hg19	N/A	enh216	N/A	Enhatls4280	enhancer	E_54				GGAACTACAGGAACTTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LCK	direct	Highly Significant	NA					AK2	chr1	33007985	33037004	3447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3856
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26013	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				TTATAGTTTCAACCAATGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26014	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				TTATAGTTTCAACCAATGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26015	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				TTATAGTTTCAACCAATGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26016	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				TCAGATAAAGTAAGCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26017	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				TCAGATAAAGTAAGCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26018	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				TCAGATAAAGTAAGCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26019	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				GTTACAGTTCTCTTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26020	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				GTTACAGTTCTCTTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26021	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				GTTACAGTTCTCTTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26022	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				TAAAAGGTATAACTTTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26023	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				TAAAAGGTATAACTTTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26024	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				TAAAAGGTATAACTTTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26025	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				CATGACCTTTTCCCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26026	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				CATGACCTTTTCCCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26027	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				CATGACCTTTTCCCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26028	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				GCAGACAACAATGACTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26029	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				GCAGACAACAATGACTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26030	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				GCAGACAACAATGACTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26031	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				GTCTCAGCATTTGGCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26032	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				GTCTCAGCATTTGGCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26033	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				GTCTCAGCATTTGGCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26034	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				TACAGCACAGCATGCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26035	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				TACAGCACAGCATGCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26036	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				TACAGCACAGCATGCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26037	hg19	N/A	enh26798	N/A	Enhatls7101	enhancer	E_59				TTTCGAAAAATGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6519	chr1	64695838	64698649	64230155	64232966	26038	hg19	N/A	N/A	N/A	Enhatls7101	enhancer	E_59				TTTCGAAAAATGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6518
enhrx-6520	chr1	64695838	64698649	64230155	64232966	26039	hg19	N/A	N/A	N/A	Enhatls7102	enhancer	E_59				TTTCGAAAAATGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOXD3	direct	Highly Significant	NA					UBE2U	chr1	64203622	64267368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6519
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26040	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ACCAAGTTTCCCTCAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26041	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				ACCAAGTTTCCCTCAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26042	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ACCAAGTTTCCCTCAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26043	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				ACCAAGTTTCCCTCAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26044	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CATGCAGATACCTAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26045	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				CATGCAGATACCTAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26046	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CATGCAGATACCTAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26047	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				CATGCAGATACCTAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26048	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GCAATTACTTAAAGCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26049	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GCAATTACTTAAAGCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26050	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GCAATTACTTAAAGCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26051	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GCAATTACTTAAAGCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26052	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GATAGCAGACATTCTGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26053	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GATAGCAGACATTCTGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26054	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GATAGCAGACATTCTGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26055	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GATAGCAGACATTCTGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26056	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TGGGCATGAGAGGCCCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26057	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				TGGGCATGAGAGGCCCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26058	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TGGGCATGAGAGGCCCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26059	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				TGGGCATGAGAGGCCCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26060	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATTTGGGACCAGCTAATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26061	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				ATTTGGGACCAGCTAATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26062	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATTTGGGACCAGCTAATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26063	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				ATTTGGGACCAGCTAATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26064	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				AAGGAGGTTGGAAACAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26065	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				AAGGAGGTTGGAAACAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26066	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				AAGGAGGTTGGAAACAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26067	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				AAGGAGGTTGGAAACAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26068	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GGAATTCCCTCCCACCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26069	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GGAATTCCCTCCCACCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26070	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GGAATTCCCTCCCACCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26071	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GGAATTCCCTCCCACCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26072	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GCAGCCTTCCATGAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26073	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GCAGCCTTCCATGAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26074	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GCAGCCTTCCATGAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26075	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GCAGCCTTCCATGAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26076	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GAGAGTTGAGCAAAGTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26077	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GAGAGTTGAGCAAAGTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26078	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GAGAGTTGAGCAAAGTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26079	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GAGAGTTGAGCAAAGTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26080	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATTATGGGATAACCAGGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26081	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				ATTATGGGATAACCAGGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26082	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATTATGGGATAACCAGGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26083	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				ATTATGGGATAACCAGGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26084	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CCCAGAATGTCCTAATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26085	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				CCCAGAATGTCCTAATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26086	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CCCAGAATGTCCTAATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26087	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				CCCAGAATGTCCTAATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26088	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CTAAGTGCCAGCAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26089	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				CTAAGTGCCAGCAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26090	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CTAAGTGCCAGCAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26091	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				CTAAGTGCCAGCAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26092	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CAGGACACTTTCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26093	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				CAGGACACTTTCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26094	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CAGGACACTTTCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26095	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				CAGGACACTTTCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26096	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CCAGACTGTCCTTTCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26097	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				CCAGACTGTCCTTTCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26098	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				CCAGACTGTCCTTTCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26099	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				CCAGACTGTCCTTTCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26100	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ACAAGCAAGAGCATTGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26101	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				ACAAGCAAGAGCATTGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26102	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ACAAGCAAGAGCATTGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26103	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				ACAAGCAAGAGCATTGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26104	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TGAGAATTGGTTCTGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26105	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				TGAGAATTGGTTCTGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26106	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TGAGAATTGGTTCTGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26107	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				TGAGAATTGGTTCTGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26108	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TATAACTTGGAATTCTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26109	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				TATAACTTGGAATTCTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26110	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				TATAACTTGGAATTCTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26111	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				TATAACTTGGAATTCTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26112	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GAGAGTTCTGCTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26113	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				GAGAGTTCTGCTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26114	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				GAGAGTTCTGCTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26115	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				GAGAGTTCTGCTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26116	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATATGCCCCAACTCCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26117	hg19	N/A	enh499	fant2409	Enhatls8639	enhancer	E_60				ATATGCCCCAACTCCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26118	hg19	N/A	enh499	N/A	Enhatls8639	enhancer	E_60				ATATGCCCCAACTCCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-7986	chr1	94240125	94255063	93774569	93789507	26119	hg19	N/A	N/A	N/A	Enhatls8639	enhancer	E_60				ATATGCCCCAACTCCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BCAR3	indirect	Non Significant	NA					BCAR3	chr1	93561740	93847150	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26120	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26121	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26122	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26123	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26124	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26125	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26126	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GATAGGAGGCGGCTGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26127	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26128	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26129	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26130	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26131	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26132	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26133	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAATGGGGCGGGAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26134	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26135	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26136	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26137	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26138	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26139	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26140	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAGTCAGCCCCGTTCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26141	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26142	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26143	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26144	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26145	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26146	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26147	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGGAAAGAACGGTCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26148	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26149	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26150	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26151	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26152	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26153	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26154	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GATCTGGGTCTGTTTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26155	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26156	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26157	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26158	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26159	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26160	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26161	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GAGGCGAGTGAAGTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26162	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26163	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26164	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26165	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26166	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26167	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26168	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GTCAGCATCTGTTATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26169	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26170	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26171	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26172	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26173	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26174	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26175	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGTTAAGGTGGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26176	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26177	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26178	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26179	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26180	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26181	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26182	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CATAGGTGTTCCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26183	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26184	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26185	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26186	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26187	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26188	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26189	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGTCATCATCTCTGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26190	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26191	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26192	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26193	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26194	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26195	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26196	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				AGAGATTCTGAGGTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26197	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26198	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26199	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26200	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26201	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26202	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26203	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TTTATGCCTTAACTTTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26204	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26205	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26206	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26207	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26208	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26209	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26210	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CTGAAGGATCGAAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26211	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26212	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26213	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26214	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26215	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26216	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26217	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGGCTCAAGGTGACTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26218	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26219	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26220	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26221	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26222	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26223	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26224	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CTAATGCTGACAAGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26225	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26226	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26227	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26228	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26229	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26230	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26231	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GCCAAGCTCAGAGTGCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26232	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26233	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26234	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26235	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26236	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26237	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26238	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TGATGTATTGATCCTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26239	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26240	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26241	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26242	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26243	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26244	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26245	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				CCCTGCAGGAGTGACTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26246	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26247	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26248	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26249	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26250	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26251	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26252	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TGTCCCCAACTTCTCAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26253	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26254	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26255	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26256	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26257	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26258	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26259	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GACACATTGGACCATGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26260	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26261	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26262	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26263	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26264	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26265	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26266	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GTCAACCAAAGGCTCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26267	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26268	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26269	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26270	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26271	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26272	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26273	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				TCCTCTCTGCTGCCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26274	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26275	hg19	N/A	enh12166	fant2822	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26276	hg19	N/A	enh12166	N/A	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26277	hg19	N/A	N/A	N/A	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26278	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26279	hg19	N/A	enh58140	fant2823	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9245	chr1	114646876	114667517	114104254	114124895	26280	hg19	N/A	enh58140	N/A	Enhatls9983	enhancer	E_63				GGAAAGACGGAGAATGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					SYT6	chr1	114089291	114153880	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9244
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26281	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GACTACAGCTTTCATTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26282	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				AGAGGTGGACGGGTAGATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26283	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GCCACATATAGACTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26284	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GCATTCAAGACTAAAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26285	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				TCCTCAACTTCCCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26286	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				AGTCCCCAAGTGCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26287	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				AACTTTACGTGAAAGAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26288	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GAGTTTACGAGGTATAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26289	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GAGCGGATTCCTCAGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26290	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				GCAACTAGTGAGTCACGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26291	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				TGCATTCTCAAAGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26292	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				TGGGGATTAATCTGCAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-9361	chr1	115710245	115713571	115167624	115170950	26293	hg19	N/A	enh12174	N/A	Enhatls10100	enhancer	E_64				ATTTCAAAACATTTCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NRAS	direct	Highly Significant	NA					TSPAN2	chr1	115048010	115089503	77590				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	9360
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26294	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				AGCATGATTTAGCTTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26295	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				AGCATGATTTAGCTTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26296	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				AGCATGATTTAGCTTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26297	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTTATAGGAGCTACTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26298	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TTTATAGGAGCTACTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26299	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTTATAGGAGCTACTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26300	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				AGAGATGATTCATAGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26301	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				AGAGATGATTCATAGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26302	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				AGAGATGATTCATAGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26303	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				ACTTTCCTTTGTATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26304	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				ACTTTCCTTTGTATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26305	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				ACTTTCCTTTGTATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26306	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTAGTGCAAGTTTTTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26307	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TTAGTGCAAGTTTTTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26308	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTAGTGCAAGTTTTTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26309	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				CCTGAGAGCCTCCAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26310	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				CCTGAGAGCCTCCAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26311	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				CCTGAGAGCCTCCAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26312	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TGTTAGTACCCACCACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26313	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TGTTAGTACCCACCACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26314	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TGTTAGTACCCACCACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26315	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				ATTAAAGCAGAGGCGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26316	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				ATTAAAGCAGAGGCGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26317	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				ATTAAAGCAGAGGCGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26318	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTTTAAAACATGTCCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26319	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TTTTAAAACATGTCCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26320	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TTTTAAAACATGTCCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26321	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TCTTGAGCAAGACCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26322	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TCTTGAGCAAGACCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26323	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TCTTGAGCAAGACCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26324	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				CATAGAGCTTGCAACAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26325	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				CATAGAGCTTGCAACAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26326	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				CATAGAGCTTGCAACAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26327	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TCCTTGTAGCACACATGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8996				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26328	hg19	N/A	enh12291	fant3233	Enhatls12199	enhancer	E_65				TCCTTGTAGCACACATGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	8611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-10969	chr1	155613859	155622405	155644068	155652614	26329	hg19	N/A	enh12291	N/A	Enhatls12199	enhancer	E_65				TCCTTGTAGCACACATGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					YY1AP1	chr1	155659442	155689000	4219				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	10968
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26330	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				CCAAAACGAGAAAGTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26331	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				CCAAAACGAGAAAGTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26332	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				TCATTCTCGGGAAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26333	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				TCATTCTCGGGAAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26334	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GAGCTTCCTGAAGGGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26335	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GAGCTTCCTGAAGGGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26336	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GTCTTCTTCCGAGGACCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26337	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GTCTTCTTCCGAGGACCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26338	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				AGGGGCCGGACCGTCGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26339	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				AGGGGCCGGACCGTCGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26340	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GGAACCCTCGGTCAGTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26341	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GGAACCCTCGGTCAGTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26342	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				AACAGCCTCTGATTACGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26343	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				AACAGCCTCTGATTACGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26344	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				CCACAGGCCCGATTTTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26345	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				CCACAGGCCCGATTTTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26346	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GCCTGAGCCACACCGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26347	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GCCTGAGCCACACCGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26348	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GAGAAACAGCAAGCGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26349	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GAGAAACAGCAAGCGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26350	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				ACCGCCCTGTGTGCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26351	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				ACCGCCCTGTGTGCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26352	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				CGGGGGAGGGAAGTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26353	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				CGGGGGAGGGAAGTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26354	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GGCGGCCTCTGGGGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26355	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GGCGGCCTCTGGGGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26356	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GTCCCTCCGATGCTACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26357	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GTCCCTCCGATGCTACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26358	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				AGAGCGTCGGCGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26359	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				AGAGCGTCGGCGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26360	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GGGCCGCCTTTTCAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26361	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GGGCCGCCTTTTCAAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26362	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				GGCGAAAGAGGCCCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26363	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				GGCGAAAGAGGCCCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11022	chr1	155825647	155832130	155855856	155862339	26364	hg19	N/A	N/A	fant3234	N/A	enhancer	E_66				AACTAATCTTGGAGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					GON4L	chr1	155749658	155859400	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11021
enhrx-11023	chr1	155825647	155832130	155855856	155862339	26365	hg19	N/A	N/A	fant3235	N/A	enhancer	E_66				AACTAATCTTGGAGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11022
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26366	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				TCTTTGGGTCTACTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26367	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				CTTTGAGACGGCAAAGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26368	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				TTCAACTGACTCTTAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26369	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				TCGTGGTCAGGAATAGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26370	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				GAAGAGATCTTGATTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26371	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				CTTCTTTCAGTTCATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26372	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				AGAACTGGTTTGTGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155853986	155855020	155884195	155885229	26373	hg19	N/A	N/A	N/A	Enhatls12262	enhancer	E_67				TTCTTGGAAGGCTTGTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26374	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				TTAAATTTTTGTAGAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26375	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				TATCCAGTTTCATCCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26376	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				ACATAGCAATTTCAACTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26377	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				ATTTTGCACGTTAGAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26378	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				GCCAAGCAATGTGTTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26379	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				ATTGCAGTGTATTGAGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26380	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				ACTCCTCTGCCAGGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26381	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				TAACTAGCTCCAGGAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26382	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				AACTCATGATGAGCAGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26383	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				TTTGTCTCAAGGCCAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11027	chr1	155861324	155864673	155891533	155894882	26384	hg19	N/A	enh12292	N/A	Enhatls12262	enhancer	E_68				TCGTACAAGCTGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SYT11	chr1	155859566	155885199	1396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11026
enhrx-11029	chr1	155877987	155885185	155908196	155915394	26385	hg19	N/A	N/A	N/A	Enhatls12264	enhancer	E_69				GTGGTGTAGGGAAGAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11028
enhrx-11030	chr1	155877987	155885185	155908196	155915394	26386	hg19	N/A	N/A	N/A	Enhatls12265	enhancer	E_69				GTGGTGTAGGGAAGAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11029
enhrx-11031	chr1	155877987	155885185	155908196	155915394	26387	hg19	N/A	N/A	N/A	Enhatls12266	enhancer	E_69				GTGGTGTAGGGAAGAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11030
enhrx-11029	chr1	155877987	155885185	155908196	155915394	26388	hg19	N/A	N/A	N/A	Enhatls12264	enhancer	E_69				GTACTCCCGTGAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11028
enhrx-11030	chr1	155877987	155885185	155908196	155915394	26389	hg19	N/A	N/A	N/A	Enhatls12265	enhancer	E_69				GTACTCCCGTGAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11029
enhrx-11031	chr1	155877987	155885185	155908196	155915394	26390	hg19	N/A	N/A	N/A	Enhatls12266	enhancer	E_69				GTACTCCCGTGAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11030
enhrx-11029	chr1	155877987	155885185	155908196	155915394	26391	hg19	N/A	N/A	N/A	Enhatls12264	enhancer	E_69				AAGCCACCTAGAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11028
enhrx-11030	chr1	155877987	155885185	155908196	155915394	26392	hg19	N/A	N/A	N/A	Enhatls12265	enhancer	E_69				AAGCCACCTAGAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11029
enhrx-11031	chr1	155877987	155885185	155908196	155915394	26393	hg19	N/A	N/A	N/A	Enhatls12266	enhancer	E_69				AAGCCACCTAGAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11030
enhrx-11029	chr1	155877987	155885185	155908196	155915394	26394	hg19	N/A	N/A	N/A	Enhatls12264	enhancer	E_69				GGGACAGGCCAGAATATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11028
enhrx-11030	chr1	155877987	155885185	155908196	155915394	26395	hg19	N/A	N/A	N/A	Enhatls12265	enhancer	E_69				GGGACAGGCCAGAATATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11029
enhrx-11031	chr1	155877987	155885185	155908196	155915394	26396	hg19	N/A	N/A	N/A	Enhatls12266	enhancer	E_69				GGGACAGGCCAGAATATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11030
enhrx-11029	chr1	155877987	155885185	155908196	155915394	26397	hg19	N/A	N/A	N/A	Enhatls12264	enhancer	E_69				TGTGACTGAACTGTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11028
enhrx-11030	chr1	155877987	155885185	155908196	155915394	26398	hg19	N/A	N/A	N/A	Enhatls12265	enhancer	E_69				TGTGACTGAACTGTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11029
enhrx-11031	chr1	155877987	155885185	155908196	155915394	26399	hg19	N/A	N/A	N/A	Enhatls12266	enhancer	E_69				TGTGACTGAACTGTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					RIT1	chr1	155897807	155911404	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11030
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26400	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GTGTGGTGAGGGCGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26401	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GTGTGGTGAGGGCGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26402	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GTGTGGTGAGGGCGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26403	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				AGTCTGTGGACAGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26404	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				AGTCTGTGGACAGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26405	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				AGTCTGTGGACAGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26406	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				TGACCTTGAGGCTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26407	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				TGACCTTGAGGCTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26408	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				TGACCTTGAGGCTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26409	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GAGAGGCTATTACCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26410	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GAGAGGCTATTACCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26411	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GAGAGGCTATTACCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26412	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				TTGTATGAATATTATTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26413	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				TTGTATGAATATTATTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26414	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				TTGTATGAATATTATTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26415	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GTAAGTCTGCTTCACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26416	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GTAAGTCTGCTTCACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26417	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GTAAGTCTGCTTCACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26418	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				TCCAAGAGAGGAAAGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26419	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				TCCAAGAGAGGAAAGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26420	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				TCCAAGAGAGGAAAGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26421	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GGGCCCAAAGCAAGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26422	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GGGCCCAAAGCAAGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26423	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GGGCCCAAAGCAAGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26424	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GAGAGTTACCCCGCTATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26425	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GAGAGTTACCCCGCTATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26426	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GAGAGTTACCCCGCTATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26427	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GGGCGCATGCACATATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26428	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GGGCGCATGCACATATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26429	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GGGCGCATGCACATATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26430	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				GCCCACGCCCACACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26431	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				GCCCACGCCCACACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26432	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				GCCCACGCCCACACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26433	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				AGTGTCTGCCAGACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26434	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				AGTGTCTGCCAGACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26435	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				AGTGTCTGCCAGACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26436	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				TATTGAGTGTGGGCATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26437	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				TATTGAGTGTGGGCATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26438	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				TATTGAGTGTGGGCATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26439	hg19	N/A	enh656	N/A	N/A	enhancer	E_70				CCTGGCCTATGGGCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26440	hg19	N/A	enh656	N/A	Enhatls12273	enhancer	E_70				CCTGGCCTATGGGCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					RXFP4	chr1	155941637	155943087	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11040	chr1	155907798	155916600	155938007	155946809	26441	hg19	N/A	N/A	N/A	Enhatls12273	enhancer	E_70				CCTGGCCTATGGGCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	22				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11039
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26442	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26443	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26444	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26445	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26446	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26447	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26448	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26449	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26450	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26451	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26452	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26453	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26454	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26455	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26456	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26457	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26458	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26459	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				CTGCTGTCCAATGTGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26460	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26461	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26462	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26463	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26464	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26465	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26466	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26467	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26468	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26469	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26470	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26471	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26472	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26473	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26474	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26475	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26476	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26477	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				CTAGCCCCAGTGCTGTGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26478	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26479	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26480	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26481	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26482	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26483	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26484	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26485	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26486	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26487	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26488	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26489	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26490	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26491	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26492	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26493	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26494	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26495	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				TCAAGACACGATGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26496	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26497	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26498	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26499	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26500	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26501	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26502	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26503	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26504	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26505	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26506	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26507	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26508	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26509	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26510	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26511	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26512	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26513	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				CGGCCACCTGGGGTGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26514	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26515	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26516	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26517	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26518	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26519	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26520	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26521	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26522	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26523	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26524	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26525	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26526	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26527	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26528	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26529	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26530	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26531	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				GCAGCATTCCCACGGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26532	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26533	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26534	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26535	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26536	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26537	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26538	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26539	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26540	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26541	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26542	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26543	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26544	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26545	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26546	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26547	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26548	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26549	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				TGATGCGCTGAGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26550	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26551	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26552	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26553	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26554	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26555	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26556	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26557	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26558	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26559	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26560	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26561	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26562	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26563	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26564	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26565	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26566	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26567	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				TGAGGTAAATGGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26568	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26569	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26570	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26571	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26572	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26573	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26574	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26575	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26576	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26577	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26578	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26579	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26580	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26581	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26582	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26583	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26584	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26585	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				CAGAATGCTAGAGCACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26586	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26587	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26588	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26589	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26590	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26591	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26592	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26593	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26594	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26595	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26596	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26597	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26598	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26599	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26600	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26601	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26602	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26603	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				TGTGAGCTGCACCCACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26604	hg19	N/A	N/A	N/A	Enhatls12278	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26605	hg19	N/A	enh94831	N/A	Enhatls12278	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26606	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26607	hg19	N/A	enh94831	N/A	Enhatls12279	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26608	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26609	hg19	N/A	enh94831	N/A	Enhatls12280	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26610	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26611	hg19	N/A	enh94831	N/A	Enhatls12281	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26612	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26613	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26614	hg19	N/A	enh94831	fant3238	Enhatls12282	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26615	hg19	N/A	enh94831	N/A	Enhatls12282	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26616	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26617	hg19	N/A	enh94831	N/A	Enhatls12283	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26618	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26619	hg19	N/A	enh94831	N/A	Enhatls12284	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26620	hg19	N/A	enh94831	N/A	N/A	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155929529	155935908	155959738	155966117	26621	hg19	N/A	enh94831	N/A	Enhatls12285	enhancer	E_71				CAGGCACTACCCCCATGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26622	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26623	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26624	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26625	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26626	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26627	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26628	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26629	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26630	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26631	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CACTCCCTCCAAGGTTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26632	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26633	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26634	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26635	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26636	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26637	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26638	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26639	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26640	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26641	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GACCAGTACTGACTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26642	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26643	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26644	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26645	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26646	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26647	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26648	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26649	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26650	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26651	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GATGCACGGGCCTGGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26652	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26653	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26654	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26655	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26656	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26657	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26658	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26659	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26660	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26661	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				AGTCAACAGTGCAGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26662	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26663	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26664	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26665	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26666	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26667	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26668	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26669	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26670	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26671	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				TGTCCAGAGCCCAGAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26672	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26673	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26674	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26675	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26676	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26677	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26678	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26679	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26680	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26681	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CAGGAGGAGGATGCGAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26682	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26683	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26684	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26685	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26686	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26687	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26688	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26689	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26690	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26691	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				AGAGCGGGAGGAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26692	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26693	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26694	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26695	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26696	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26697	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26698	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26699	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26700	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26701	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				TGGGCGGGAGAGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26702	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26703	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26704	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26705	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26706	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26707	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26708	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26709	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26710	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26711	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GCTGGGGAAGCAGGAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26712	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26713	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26714	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26715	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26716	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26717	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26718	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26719	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26720	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26721	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GGGCATGACCGGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26722	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26723	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26724	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26725	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26726	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26727	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26728	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26729	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26730	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26731	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				ACCTTCATCCACCATCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26732	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26733	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26734	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26735	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26736	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26737	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26738	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26739	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26740	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26741	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GGAGTTTTCTTCCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26742	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26743	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26744	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26745	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26746	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26747	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26748	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26749	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26750	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26751	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				ATCCTGAGCCTGGATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26752	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26753	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26754	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26755	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26756	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26757	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26758	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26759	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26760	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26761	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CCAACGGAAGTGGTATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26762	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26763	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26764	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26765	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26766	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26767	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26768	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26769	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26770	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26771	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GATGGGGCTGATGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26772	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26773	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26774	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26775	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26776	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26777	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26778	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26779	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26780	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26781	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CTCTAGCTGACACATCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26782	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26783	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26784	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26785	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26786	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26787	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26788	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26789	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26790	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26791	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				AGCAGAGCCTGATATCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26792	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26793	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26794	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26795	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26796	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26797	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26798	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26799	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26800	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26801	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GCCATAGGAGCCAAATAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26802	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26803	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26804	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26805	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26806	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26807	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26808	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26809	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26810	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26811	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GAGTTCAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26812	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26813	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26814	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26815	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26816	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26817	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26818	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26819	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26820	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26821	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GCTCAGATAATAGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26822	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26823	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26824	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26825	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26826	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26827	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26828	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26829	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26830	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26831	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				TTGCTGTTGTCAGTGGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26832	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26833	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26834	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26835	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26836	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26837	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26838	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26839	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26840	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26841	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				TAGATTCCCATTCGCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26842	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26843	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26844	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26845	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26846	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26847	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26848	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26849	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26850	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26851	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				ATGGTGGCTAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26852	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26853	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26854	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26855	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26856	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26857	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26858	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26859	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26860	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26861	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GTCTGTCCGTACCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26862	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26863	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26864	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26865	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26866	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26867	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26868	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26869	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26870	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26871	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CTGCAAGCATCGGGATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26872	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26873	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26874	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26875	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26876	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26877	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26878	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26879	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26880	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26881	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CCACTACCGTCTGTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26882	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26883	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26884	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26885	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26886	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26887	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26888	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26889	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26890	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26891	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CTGGGCTGGGGGCAAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26892	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26893	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26894	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26895	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26896	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26897	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26898	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26899	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26900	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26901	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				AGGGCTGCAGAGTTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26902	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26903	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26904	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26905	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26906	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26907	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26908	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26909	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26910	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26911	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				GTTCGCCTTCCCCTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26912	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26913	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26914	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26915	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26916	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26917	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26918	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26919	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26920	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26921	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				TGCACTATTTGGCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26922	hg19	N/A	enh94831	N/A	Enhatls12287	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11045	chr1	155937159	155965679	155967368	155995888	26923	hg19	N/A	N/A	N/A	Enhatls12287	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11044
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26924	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26925	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26926	hg19	N/A	enh12293	fant3239	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26927	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26928	hg19	N/A	enh12293	fant3240	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26929	hg19	N/A	enh12293	N/A	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11046	chr1	155937159	155965679	155967368	155995888	26930	hg19	N/A	N/A	N/A	Enhatls12288	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11045
enhrx-11047	chr1	155937159	155965679	155967368	155995888	26931	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_72				CAGTTGGTGCCACATAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26932	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				TTAGCCTCTGAAGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26933	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				TTAGCCTCTGAAGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26934	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				TTAGCCTCTGAAGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26935	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				TTGGGTTTGAGAACAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26936	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				TTGGGTTTGAGAACAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26937	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				TTGGGTTTGAGAACAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26938	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				CATTCTCCTGAGCAAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26939	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				CATTCTCCTGAGCAAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26940	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				CATTCTCCTGAGCAAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26941	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				CCTGTAACCTGGCCAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26942	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				CCTGTAACCTGGCCAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26943	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				CCTGTAACCTGGCCAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26944	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				TGGCAGAGGGCTACTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26945	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				TGGCAGAGGGCTACTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26946	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				TGGCAGAGGGCTACTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26947	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				GGGGGAGCAGAATCTAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26948	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				GGGGGAGCAGAATCTAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26949	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				GGGGGAGCAGAATCTAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26950	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				TGTCCAACTCAGGAATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26951	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				TGTCCAACTCAGGAATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26952	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				TGTCCAACTCAGGAATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26953	hg19	N/A	enh79219	N/A	Enhatls12289	enhancer	E_73				TGGGCTCTAAGCGTGACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26954	hg19	N/A	N/A	N/A	Enhatls12289	enhancer	E_73				TGGGCTCTAAGCGTGACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11047	chr1	155969856	155977734	156000065	156007943	26955	hg19	N/A	enh103107	N/A	Enhatls12289	enhancer	E_73				TGGGCTCTAAGCGTGACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF2	chr1	155946850	156007070	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11046
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26956	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26957	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26958	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26959	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26960	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26961	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26962	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26963	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26964	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26965	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26966	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26967	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26968	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26969	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26970	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26971	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26972	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	26973	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26974	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26975	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26976	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26977	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26978	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26979	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26980	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26981	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26982	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26983	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	26984	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	26985	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	26986	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	26987	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	26988	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGATGATTAAGCTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26989	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26990	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26991	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26992	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26993	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26994	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26995	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26996	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26997	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26998	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	26999	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27000	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27001	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27002	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27003	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27004	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27005	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27006	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27007	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27008	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27009	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27010	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27011	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27012	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27013	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27014	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27015	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27016	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27017	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27018	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27019	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27020	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27021	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TGATGAGTGCCTCCAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27022	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27023	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27024	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27025	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27026	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27027	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27028	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27029	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27030	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27031	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27032	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27033	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27034	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27035	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27036	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27037	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27038	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27039	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27040	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27041	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27042	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27043	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27044	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27045	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27046	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27047	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27048	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27049	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27050	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27051	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27052	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27053	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27054	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GATATTTACTCAGTACCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27055	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27056	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27057	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27058	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27059	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27060	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27061	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27062	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27063	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27064	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27065	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27066	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27067	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27068	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27069	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27070	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27071	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27072	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27073	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27074	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27075	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27076	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27077	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27078	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27079	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27080	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27081	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27082	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27083	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27084	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27085	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27086	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27087	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ACTAGCCTGGATGCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27088	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27089	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27090	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27091	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27092	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27093	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27094	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27095	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27096	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27097	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27098	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27099	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27100	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27101	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27102	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27103	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27104	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27105	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27106	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27107	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27108	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27109	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27110	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27111	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27112	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27113	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27114	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27115	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27116	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27117	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27118	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27119	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27120	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCATGAGATGAGCAAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27121	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27122	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27123	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27124	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27125	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27126	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27127	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27128	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27129	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27130	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27131	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27132	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27133	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27134	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27135	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27136	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27137	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27138	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27139	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27140	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27141	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27142	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27143	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27144	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27145	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27146	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27147	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27148	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27149	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27150	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27151	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27152	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27153	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TGGAACTTCACCCAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27154	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27155	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27156	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27157	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27158	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27159	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27160	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27161	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27162	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27163	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27164	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27165	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27166	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27167	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27168	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27169	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27170	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27171	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27172	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27173	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27174	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27175	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27176	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27177	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27178	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27179	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27180	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27181	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27182	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27183	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27184	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27185	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27186	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				AGGGGATGTCCAGCCTAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27187	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27188	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27189	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27190	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27191	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27192	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27193	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27194	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27195	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27196	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27197	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27198	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27199	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27200	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27201	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27202	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27203	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27204	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27205	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27206	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27207	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27208	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27209	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27210	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27211	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27212	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27213	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27214	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27215	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27216	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27217	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27218	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27219	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ATGAGGCTGCTATTCTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27220	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27221	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27222	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27223	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27224	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27225	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27226	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27227	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27228	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27229	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27230	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27231	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27232	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27233	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27234	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27235	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27236	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27237	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27238	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27239	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27240	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27241	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27242	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27243	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27244	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27245	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27246	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27247	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27248	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27249	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27250	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27251	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27252	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GTAGTGTTTGTGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27253	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27254	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27255	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27256	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27257	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27258	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27259	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27260	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27261	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27262	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27263	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27264	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27265	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27266	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27267	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27268	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27269	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27270	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27271	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27272	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27273	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27274	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27275	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27276	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27277	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27278	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27279	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27280	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27281	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27282	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27283	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27284	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27285	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GATTCACCACAGGAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27286	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27287	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27288	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27289	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27290	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27291	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27292	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27293	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27294	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27295	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27296	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27297	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27298	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27299	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27300	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27301	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27302	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27303	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27304	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27305	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27306	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27307	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27308	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27309	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27310	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27311	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27312	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27313	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27314	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27315	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27316	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27317	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27318	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				AGCATGCATTCCCCCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27319	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27320	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27321	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27322	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27323	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27324	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27325	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27326	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27327	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27328	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27329	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27330	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27331	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27332	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27333	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27334	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27335	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27336	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27337	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27338	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27339	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27340	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27341	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27342	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27343	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27344	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27345	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27346	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27347	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27348	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27349	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27350	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27351	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TATTTTTCAAACTTTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27352	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27353	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27354	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27355	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27356	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27357	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27358	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27359	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27360	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27361	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27362	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27363	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27364	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27365	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27366	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27367	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27368	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27369	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27370	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27371	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27372	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27373	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27374	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27375	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27376	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27377	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27378	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27379	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27380	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27381	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27382	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27383	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27384	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TATGGGACCCTTGGAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27385	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27386	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27387	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27388	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27389	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27390	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27391	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27392	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27393	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27394	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27395	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27396	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27397	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27398	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27399	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27400	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27401	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27402	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27403	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27404	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27405	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27406	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27407	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27408	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27409	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27410	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27411	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27412	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27413	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27414	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27415	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27416	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27417	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				AATAAGGCAGACCCGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27418	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27419	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27420	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27421	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27422	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27423	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27424	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27425	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27426	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27427	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27428	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27429	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27430	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27431	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27432	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27433	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27434	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27435	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27436	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27437	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27438	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27439	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27440	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27441	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27442	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27443	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27444	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27445	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27446	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27447	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27448	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27449	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27450	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCACTGAGAAGTCCATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27451	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27452	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27453	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27454	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27455	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27456	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27457	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27458	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27459	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27460	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27461	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27462	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27463	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27464	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27465	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27466	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27467	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27468	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27469	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27470	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27471	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27472	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27473	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27474	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27475	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27476	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27477	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27478	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27479	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27480	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27481	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27482	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27483	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCCCCCATGGGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27484	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27485	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27486	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27487	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27488	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27489	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27490	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27491	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27492	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27493	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27494	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27495	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27496	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27497	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27498	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27499	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27500	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27501	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27502	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27503	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27504	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27505	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27506	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27507	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27508	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27509	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27510	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27511	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27512	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27513	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27514	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27515	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27516	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGAGAACCTCCATAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27517	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27518	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27519	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27520	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27521	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27522	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27523	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27524	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27525	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27526	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27527	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27528	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27529	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27530	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27531	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27532	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27533	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27534	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27535	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27536	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27537	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27538	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27539	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27540	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27541	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27542	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27543	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27544	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27545	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27546	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27547	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27548	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27549	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTGGTAGGCAGGACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27550	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27551	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27552	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27553	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27554	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27555	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27556	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27557	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27558	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27559	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27560	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27561	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27562	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27563	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27564	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27565	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27566	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27567	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27568	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27569	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27570	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27571	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27572	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27573	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27574	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27575	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27576	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27577	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27578	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27579	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27580	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27581	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27582	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGAGGGTCCTCATCCTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27583	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27584	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27585	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27586	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27587	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27588	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27589	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27590	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27591	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27592	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27593	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27594	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27595	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27596	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27597	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27598	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27599	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27600	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27601	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27602	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27603	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27604	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27605	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27606	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27607	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27608	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27609	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27610	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27611	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27612	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27613	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27614	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27615	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TCCCAGACAGAGGAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27616	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27617	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27618	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27619	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27620	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27621	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27622	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27623	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27624	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27625	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27626	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27627	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27628	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27629	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27630	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27631	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27632	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27633	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27634	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27635	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27636	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27637	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27638	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27639	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27640	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27641	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27642	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27643	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27644	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27645	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27646	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27647	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27648	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CCATCTGCCCACCATCCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27649	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27650	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27651	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27652	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27653	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27654	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27655	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27656	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27657	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27658	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27659	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27660	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27661	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27662	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27663	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27664	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27665	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27666	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27667	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27668	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27669	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27670	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27671	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27672	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27673	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27674	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27675	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27676	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27677	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27678	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27679	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27680	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27681	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTTGCAAGCCCTCATTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27682	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27683	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27684	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27685	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27686	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27687	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27688	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27689	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27690	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27691	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27692	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27693	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27694	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27695	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27696	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27697	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27698	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27699	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27700	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27701	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27702	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27703	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27704	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27705	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27706	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27707	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27708	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27709	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27710	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27711	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27712	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27713	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27714	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CAACAACAGCCCACATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27715	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27716	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27717	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27718	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27719	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27720	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27721	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27722	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27723	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27724	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27725	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27726	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27727	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27728	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27729	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27730	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27731	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27732	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27733	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27734	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27735	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27736	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27737	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27738	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27739	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27740	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27741	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27742	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27743	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27744	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27745	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27746	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27747	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CCTGCCCAAGGACCAGAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27748	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27749	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27750	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27751	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27752	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27753	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27754	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27755	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27756	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27757	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27758	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27759	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27760	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27761	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27762	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27763	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27764	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27765	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27766	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27767	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27768	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27769	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27770	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27771	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27772	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27773	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27774	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27775	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27776	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27777	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27778	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27779	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27780	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGCCGGGTTCGGGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27781	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27782	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27783	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27784	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27785	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27786	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27787	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27788	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27789	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27790	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27791	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27792	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27793	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27794	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27795	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27796	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27797	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27798	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27799	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27800	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27801	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27802	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27803	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27804	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27805	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27806	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27807	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27808	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27809	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27810	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27811	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27812	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27813	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TCACAGCCCCCACTGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27814	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27815	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27816	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27817	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27818	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27819	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27820	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27821	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27822	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27823	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27824	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27825	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27826	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27827	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27828	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27829	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27830	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27831	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27832	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27833	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27834	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27835	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27836	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27837	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27838	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27839	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27840	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27841	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27842	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27843	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27844	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27845	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27846	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CAAGAGATGTCCCAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27847	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27848	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27849	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27850	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27851	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27852	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27853	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27854	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27855	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27856	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27857	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27858	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27859	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27860	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27861	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27862	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27863	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27864	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27865	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27866	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27867	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27868	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27869	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27870	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27871	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27872	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27873	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27874	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27875	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27876	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27877	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27878	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27879	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TTGGGCGTGTTGGGCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27880	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27881	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27882	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27883	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27884	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27885	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27886	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27887	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27888	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27889	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27890	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27891	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27892	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27893	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27894	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27895	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27896	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27897	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27898	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27899	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27900	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27901	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27902	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27903	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27904	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27905	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27906	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27907	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27908	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27909	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27910	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27911	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27912	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTGTGTAGGCTGGCTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27913	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27914	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27915	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27916	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27917	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27918	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27919	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27920	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27921	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27922	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27923	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27924	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27925	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27926	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27927	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27928	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27929	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27930	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27931	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27932	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27933	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27934	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27935	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27936	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27937	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27938	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27939	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27940	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27941	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27942	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27943	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27944	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27945	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ACAACAGTTGCTAAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27946	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27947	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27948	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27949	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27950	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27951	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27952	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27953	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27954	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27955	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27956	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27957	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27958	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27959	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27960	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27961	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27962	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27963	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27964	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27965	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27966	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27967	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27968	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27969	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27970	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27971	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27972	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27973	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27974	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	27975	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	27976	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	27977	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	27978	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TGGAGCACTGGCGTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27979	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27980	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27981	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27982	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27983	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27984	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27985	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27986	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27987	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27988	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27989	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27990	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27991	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27992	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27993	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27994	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	27995	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	27996	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27997	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27998	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	27999	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28000	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28001	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28002	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28003	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28004	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28005	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28006	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28007	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28008	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28009	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28010	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28011	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GAAAGCCAAGAATAGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28012	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28013	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28014	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28015	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28016	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28017	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28018	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28019	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28020	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28021	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28022	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28023	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28024	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28025	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28026	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28027	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28028	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28029	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28030	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28031	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28032	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28033	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28034	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28035	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28036	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28037	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28038	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28039	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28040	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28041	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28042	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28043	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28044	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGACTTCTTTAGGGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28045	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28046	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28047	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28048	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28049	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28050	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28051	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28052	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28053	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28054	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28055	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28056	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28057	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28058	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28059	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28060	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28061	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28062	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28063	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28064	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28065	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28066	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28067	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28068	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28069	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28070	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28071	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28072	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28073	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28074	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28075	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28076	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28077	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CCCTGGGGGGAGCAAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28078	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28079	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28080	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28081	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28082	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28083	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28084	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28085	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28086	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28087	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28088	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28089	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28090	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28091	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28092	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28093	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28094	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28095	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28096	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28097	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28098	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28099	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28100	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28101	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28102	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28103	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28104	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28105	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28106	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28107	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28108	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28109	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28110	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGCTGCCCACGTGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28111	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28112	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28113	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28114	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28115	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28116	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28117	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28118	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28119	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28120	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28121	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28122	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28123	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28124	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28125	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28126	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28127	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28128	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28129	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28130	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28131	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28132	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28133	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28134	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28135	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28136	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28137	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28138	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28139	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28140	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28141	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28142	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28143	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGAAGTGGGCGCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28144	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28145	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28146	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28147	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28148	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28149	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28150	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28151	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28152	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28153	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28154	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28155	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28156	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28157	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28158	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28159	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28160	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28161	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28162	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28163	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28164	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28165	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28166	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28167	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28168	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28169	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28170	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28171	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28172	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28173	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28174	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28175	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28176	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTCTGCCCTCTAGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28177	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28178	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28179	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28180	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28181	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28182	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28183	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28184	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28185	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28186	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28187	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28188	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28189	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28190	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28191	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28192	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28193	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28194	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28195	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28196	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28197	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28198	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28199	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28200	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28201	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28202	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28203	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28204	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28205	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28206	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28207	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28208	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28209	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTTGAGCCTCACGCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28210	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28211	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28212	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28213	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28214	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28215	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28216	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28217	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28218	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28219	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28220	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28221	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28222	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28223	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28224	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28225	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28226	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28227	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28228	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28229	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28230	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28231	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28232	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28233	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28234	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28235	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28236	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28237	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28238	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28239	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28240	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28241	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28242	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TGAGGAGGGGGAAGGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28243	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28244	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28245	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28246	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28247	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28248	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28249	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28250	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28251	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28252	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28253	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28254	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28255	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28256	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28257	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28258	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28259	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28260	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28261	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28262	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28263	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28264	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28265	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28266	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28267	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28268	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28269	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28270	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28271	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28272	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28273	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28274	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28275	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ACACTGAGTCACCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28276	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28277	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28278	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28279	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28280	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28281	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28282	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28283	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28284	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28285	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28286	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28287	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28288	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28289	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28290	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28291	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28292	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28293	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28294	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28295	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28296	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28297	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28298	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28299	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28300	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28301	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28302	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28303	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28304	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28305	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28306	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28307	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28308	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TCCCGAGGTCCGACAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28309	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28310	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28311	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28312	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28313	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28314	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28315	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28316	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28317	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28318	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28319	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28320	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28321	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28322	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28323	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28324	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28325	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28326	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28327	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28328	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28329	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28330	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28331	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28332	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28333	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28334	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28335	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28336	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28337	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28338	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28339	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28340	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28341	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GTCGGAGTGCGCCGGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28342	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28343	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28344	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28345	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28346	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28347	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28348	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28349	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28350	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28351	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28352	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28353	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28354	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28355	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28356	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28357	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28358	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28359	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28360	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28361	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28362	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28363	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28364	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28365	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28366	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28367	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28368	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28369	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28370	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28371	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28372	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28373	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28374	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGGTCCCGGAAAGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28375	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28376	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28377	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28378	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28379	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28380	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28381	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28382	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28383	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28384	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28385	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28386	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28387	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28388	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28389	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28390	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28391	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28392	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28393	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28394	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28395	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28396	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28397	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28398	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28399	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28400	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28401	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28402	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28403	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28404	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28405	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28406	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28407	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTCTCTCCTAGCCAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28408	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28409	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28410	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28411	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28412	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28413	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28414	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28415	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28416	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28417	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28418	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28419	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28420	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28421	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28422	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28423	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28424	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28425	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28426	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28427	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28428	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28429	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28430	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28431	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28432	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28433	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28434	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28435	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28436	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28437	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28438	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28439	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28440	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCACATAGTTATTAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28441	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28442	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28443	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28444	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28445	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28446	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28447	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28448	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28449	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28450	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28451	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28452	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28453	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28454	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28455	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28456	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28457	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28458	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28459	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28460	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28461	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28462	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28463	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28464	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28465	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28466	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28467	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28468	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28469	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28470	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28471	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28472	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28473	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GTAGAATGTCCTGAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28474	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28475	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28476	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28477	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28478	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28479	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28480	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28481	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28482	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28483	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28484	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28485	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28486	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28487	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28488	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28489	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28490	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28491	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28492	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28493	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28494	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28495	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28496	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28497	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28498	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28499	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28500	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28501	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28502	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28503	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28504	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28505	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28506	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCAAAAGAAGTAGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28507	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28508	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28509	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28510	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28511	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28512	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28513	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28514	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28515	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28516	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28517	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28518	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28519	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28520	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28521	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28522	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28523	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28524	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28525	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28526	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28527	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28528	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28529	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28530	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28531	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28532	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28533	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28534	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28535	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28536	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28537	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28538	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28539	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GATTTCTAGAGAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28540	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28541	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28542	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28543	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28544	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28545	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28546	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28547	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28548	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28549	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28550	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28551	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28552	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28553	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28554	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28555	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28556	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28557	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28558	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28559	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28560	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28561	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28562	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28563	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28564	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28565	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28566	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28567	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28568	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28569	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28570	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28571	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28572	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGTCCTGGACAATGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28573	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28574	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28575	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28576	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28577	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28578	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28579	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28580	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28581	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28582	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28583	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28584	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28585	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28586	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28587	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28588	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28589	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28590	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28591	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28592	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28593	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28594	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28595	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28596	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28597	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28598	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28599	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28600	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28601	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28602	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28603	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28604	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28605	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ATCAACGTGGCATTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28606	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28607	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28608	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28609	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28610	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28611	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28612	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28613	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28614	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28615	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28616	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28617	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28618	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28619	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28620	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28621	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28622	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28623	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28624	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28625	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28626	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28627	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28628	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28629	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28630	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28631	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28632	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28633	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28634	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28635	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28636	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28637	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28638	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TTGCGTCTGAACATGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28639	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28640	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28641	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28642	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28643	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28644	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28645	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28646	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28647	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28648	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28649	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28650	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28651	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28652	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28653	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28654	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28655	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28656	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28657	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28658	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28659	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28660	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28661	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28662	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28663	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28664	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28665	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28666	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28667	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28668	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28669	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28670	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28671	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTCTGCCTGGAATTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28672	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28673	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28674	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28675	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28676	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28677	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28678	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28679	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28680	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28681	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28682	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28683	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28684	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28685	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28686	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28687	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28688	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28689	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28690	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28691	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28692	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28693	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28694	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28695	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28696	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28697	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28698	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28699	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28700	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28701	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28702	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28703	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28704	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTCTGGTAGGGGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28705	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28706	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28707	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28708	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28709	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28710	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28711	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28712	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28713	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28714	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28715	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28716	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28717	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28718	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28719	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28720	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28721	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28722	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28723	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28724	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28725	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28726	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28727	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28728	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28729	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28730	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28731	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28732	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28733	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28734	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28735	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28736	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28737	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGCGATGTTCCTGGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28738	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28739	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28740	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28741	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28742	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28743	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28744	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28745	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28746	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28747	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28748	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28749	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28750	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28751	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28752	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28753	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28754	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28755	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28756	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28757	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28758	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28759	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28760	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28761	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28762	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28763	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28764	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28765	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28766	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28767	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28768	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28769	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28770	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CCCATTGCCAGGCAGCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28771	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28772	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28773	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28774	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28775	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28776	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28777	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28778	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28779	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28780	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28781	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28782	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28783	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28784	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28785	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28786	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28787	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28788	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28789	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28790	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28791	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28792	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28793	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28794	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28795	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28796	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28797	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28798	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28799	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28800	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28801	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28802	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28803	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTGTAGCTAAAAATAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28804	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28805	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28806	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28807	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28808	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28809	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28810	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28811	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28812	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28813	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28814	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28815	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28816	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28817	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28818	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28819	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28820	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28821	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28822	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28823	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28824	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28825	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28826	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28827	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28828	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28829	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28830	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28831	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28832	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28833	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28834	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28835	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28836	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CAGGCTAGGCCCGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28837	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28838	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28839	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28840	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28841	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28842	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28843	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28844	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28845	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28846	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28847	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28848	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28849	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28850	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28851	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28852	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28853	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28854	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28855	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28856	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28857	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28858	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28859	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28860	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28861	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28862	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28863	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28864	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28865	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28866	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28867	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28868	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28869	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CCGGCCCTGGCTTCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28870	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28871	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28872	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28873	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28874	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28875	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28876	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28877	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28878	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28879	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28880	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28881	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28882	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28883	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28884	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28885	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28886	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28887	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28888	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28889	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28890	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28891	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28892	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28893	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28894	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28895	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28896	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28897	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28898	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28899	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28900	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28901	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28902	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CAAAGGGGCTAGGTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28903	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28904	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28905	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28906	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28907	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28908	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28909	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28910	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28911	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28912	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28913	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28914	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28915	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28916	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28917	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28918	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28919	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28920	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28921	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28922	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28923	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28924	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28925	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28926	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28927	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28928	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28929	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28930	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28931	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28932	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28933	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28934	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28935	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTCTTCAGACCCCTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28936	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28937	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28938	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28939	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28940	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28941	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28942	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28943	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28944	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28945	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28946	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28947	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28948	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28949	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28950	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28951	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28952	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28953	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28954	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28955	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28956	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28957	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28958	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28959	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28960	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28961	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28962	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28963	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28964	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28965	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28966	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	28967	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	28968	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGGTGGGGAGGGGAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28969	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28970	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28971	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28972	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28973	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28974	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28975	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28976	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28977	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28978	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28979	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28980	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28981	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28982	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28983	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28984	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	28985	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	28986	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28987	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28988	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28989	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28990	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28991	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28992	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28993	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28994	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28995	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28996	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	28997	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	28998	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	28999	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29000	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29001	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTCTTGAGGCGAGAAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29002	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29003	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29004	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29005	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29006	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29007	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29008	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29009	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29010	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29011	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29012	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29013	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29014	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29015	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29016	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29017	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29018	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29019	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29020	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29021	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29022	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29023	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29024	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29025	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29026	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29027	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29028	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29029	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29030	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29031	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29032	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29033	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29034	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCAGGACACGGGCGAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29035	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29036	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29037	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29038	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29039	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29040	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29041	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29042	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29043	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29044	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29045	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29046	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29047	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29048	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29049	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29050	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29051	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29052	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29053	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29054	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29055	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29056	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29057	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29058	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29059	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29060	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29061	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29062	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29063	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29064	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29065	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29066	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29067	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ATGAGTCACCTGAGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29068	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29069	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29070	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29071	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29072	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29073	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29074	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29075	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29076	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29077	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29078	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29079	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29080	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29081	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29082	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29083	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29084	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29085	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29086	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29087	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29088	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29089	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29090	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29091	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29092	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29093	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29094	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29095	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29096	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29097	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29098	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29099	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29100	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GTGCCGTCCCCGTGCTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29101	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29102	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29103	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29104	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29105	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29106	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29107	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29108	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29109	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29110	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29111	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29112	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29113	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29114	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29115	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29116	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29117	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29118	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29119	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29120	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29121	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29122	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29123	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29124	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29125	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29126	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29127	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29128	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29129	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29130	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29131	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29132	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29133	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGCATTCGGTCCCAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29134	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29135	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29136	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29137	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29138	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29139	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29140	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29141	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29142	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29143	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29144	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29145	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29146	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29147	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29148	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29149	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29150	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29151	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29152	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29153	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29154	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29155	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29156	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29157	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29158	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29159	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29160	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29161	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29162	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29163	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29164	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29165	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29166	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GAAATGGCACTTGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29167	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29168	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29169	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29170	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29171	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29172	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29173	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29174	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29175	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29176	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29177	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29178	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29179	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29180	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29181	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29182	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29183	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29184	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29185	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29186	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29187	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29188	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29189	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29190	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29191	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29192	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29193	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29194	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29195	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29196	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29197	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29198	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29199	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ACGGGGAGCTCCCATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29200	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29201	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29202	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29203	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29204	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29205	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29206	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29207	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29208	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29209	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29210	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29211	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29212	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29213	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29214	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29215	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29216	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29217	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29218	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29219	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29220	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29221	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29222	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29223	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29224	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29225	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29226	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29227	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29228	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29229	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29230	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29231	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29232	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				AGAAAAACCACGAGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29233	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29234	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29235	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29236	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29237	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29238	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29239	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29240	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29241	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29242	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29243	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29244	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29245	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29246	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29247	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29248	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29249	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29250	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29251	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29252	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29253	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29254	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29255	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29256	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29257	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29258	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29259	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29260	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29261	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29262	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29263	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29264	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29265	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTAGTCAAAACCTCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29266	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29267	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29268	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29269	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29270	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29271	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29272	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29273	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29274	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29275	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29276	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29277	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29278	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29279	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29280	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29281	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29282	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29283	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29284	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29285	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29286	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29287	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29288	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29289	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29290	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29291	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29292	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29293	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29294	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29295	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29296	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29297	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29298	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GTAGGGCTCAGCCTTCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29299	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29300	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29301	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29302	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29303	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29304	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29305	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29306	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29307	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29308	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29309	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29310	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29311	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29312	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29313	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29314	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29315	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29316	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29317	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29318	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29319	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29320	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29321	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29322	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29323	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29324	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29325	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29326	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29327	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29328	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29329	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29330	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29331	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GACCTCAGACAAGGATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29332	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29333	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29334	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29335	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29336	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29337	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29338	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29339	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29340	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29341	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29342	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29343	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29344	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29345	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29346	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29347	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29348	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29349	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29350	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29351	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29352	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29353	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29354	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29355	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29356	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29357	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29358	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29359	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29360	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29361	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29362	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29363	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29364	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				TGTGTAAAAGGGACTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29365	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29366	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29367	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29368	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29369	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29370	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29371	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29372	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29373	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29374	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29375	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29376	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29377	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29378	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29379	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29380	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29381	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29382	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29383	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29384	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29385	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29386	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29387	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29388	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29389	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29390	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29391	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29392	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29393	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29394	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29395	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29396	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29397	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GCTCAGATCGAGAAGTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29398	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29399	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29400	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29401	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29402	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29403	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29404	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29405	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29406	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29407	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29408	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29409	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29410	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29411	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29412	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29413	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29414	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29415	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29416	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29417	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29418	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29419	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29420	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29421	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29422	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29423	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29424	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29425	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29426	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29427	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29428	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29429	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29430	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGCTAAGTAAGGCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29431	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29432	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29433	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29434	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29435	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29436	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29437	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29438	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29439	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29440	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29441	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29442	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29443	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29444	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29445	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29446	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29447	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29448	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29449	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29450	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29451	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29452	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29453	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29454	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29455	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29456	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29457	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29458	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29459	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29460	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29461	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29462	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29463	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGAAAAGCATTCATATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29464	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29465	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29466	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29467	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29468	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29469	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29470	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29471	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29472	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29473	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29474	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29475	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29476	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29477	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29478	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29479	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29480	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29481	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29482	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29483	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29484	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29485	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29486	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29487	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29488	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29489	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29490	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29491	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29492	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29493	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29494	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29495	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29496	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				GGTTTTCAAGGACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29497	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29498	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29499	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29500	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29501	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29502	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29503	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29504	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29505	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29506	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29507	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29508	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29509	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29510	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29511	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29512	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29513	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29514	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29515	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29516	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29517	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29518	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29519	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29520	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29521	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29522	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29523	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29524	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29525	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29526	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29527	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29528	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29529	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				ATGCAAACCAACCTAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29530	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29531	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29532	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29533	hg19	hs2128	enh12294	fant3242	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29534	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29535	hg19	hs2128	enh12294	fant3243	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29536	hg19	hs2128	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29537	hg19	N/A	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29538	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29539	hg19	hs2129	enh12294	fant3244	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29540	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29541	hg19	hs2129	enh12294	fant3245	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29542	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29543	hg19	hs2129	enh12294	fant3246	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29544	hg19	hs2129	enh12294	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29545	hg19	hs2129	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11062	chr1	156063025	156105598	156093234	156135807	29546	hg19	N/A	N/A	N/A	Enhatls12307	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11061
enhrx-11063	chr1	156063025	156105598	156093234	156135807	29547	hg19	N/A	enh27147	N/A	N/A	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11062
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29548	hg19	N/A	N/A	N/A	Enhatls12308	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29549	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29550	hg19	N/A	enh12295	fant3247	Enhatls12308	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29551	hg19	N/A	enh12295	N/A	Enhatls12308	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29552	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29553	hg19	N/A	enh12295	fant3248	N/A	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29554	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29555	hg19	N/A	enh12295	N/A	Enhatls12309	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29556	hg19	N/A	enh12295	N/A	N/A	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29557	hg19	N/A	enh12295	N/A	Enhatls12310	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11064	chr1	156063025	156105598	156093234	156135807	29558	hg19	N/A	N/A	N/A	Enhatls12310	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11063
enhrx-11065	chr1	156063025	156105598	156093234	156135807	29559	hg19	N/A	N/A	N/A	Enhatls12311	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11064
enhrx-11066	chr1	156063025	156105598	156093234	156135807	29560	hg19	N/A	N/A	N/A	Enhatls12312	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11065
enhrx-11067	chr1	156063025	156105598	156093234	156135807	29561	hg19	N/A	N/A	N/A	Enhatls12313	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11066
enhrx-11068	chr1	156063025	156105598	156093234	156135807	29562	hg19	N/A	N/A	N/A	Enhatls12314	enhancer	E_74				CTGTGTGCCTAGACAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					LMNA	chr1	156082577	156140081	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11067
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29563	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				CTCGCTCTGTCGCCGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29564	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				CTCGCTCTGTCGCCGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29565	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				AATAAATTAGCCGGGAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29566	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				AATAAATTAGCCGGGAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29567	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				TTCTGGGACGCCGAGTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29568	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				TTCTGGGACGCCGAGTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29569	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				GTTGGGCTCTTTCTAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29570	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				GTTGGGCTCTTTCTAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29571	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				GGGCATAACGAAGGTAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29572	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				GGGCATAACGAAGGTAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29573	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				GCCGCACTTCCGAGAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29574	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				GCCGCACTTCCGAGAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29575	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				TTACCGCCCCCTGCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29576	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				TTACCGCCCCCTGCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29577	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				GACTGGGCTACCGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29578	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				GACTGGGCTACCGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29579	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				ACGGCATTCGCTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29580	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				ACGGCATTCGCTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29581	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				TGTCAGGGACCTCAAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29582	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				TGTCAGGGACCTCAAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29583	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				AATGAAGGACAACTGCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29584	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				AATGAAGGACAACTGCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29585	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				CAGCGAAGAAGCACGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29586	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				CAGCGAAGAAGCACGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29587	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				GTCTGTGATGAGGGATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29588	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				GTCTGTGATGAGGGATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11092	chr1	156162425	156168725	156192634	156198934	29589	hg19	N/A	N/A	N/A	Enhatls12337	enhancer	E_75				TCACCATGTCCGAGGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11091
enhrx-11093	chr1	156162425	156168725	156192634	156198934	29590	hg19	N/A	N/A	N/A	Enhatls12338	enhancer	E_75				TCACCATGTCCGAGGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SLC25A44	chr1	156193931	156212796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11092
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29591	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29592	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29593	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29594	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29595	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29596	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29597	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29598	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29599	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29600	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29601	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29602	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29603	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29604	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29605	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29606	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29607	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29608	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29609	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29610	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29611	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29612	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29613	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29614	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29615	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29616	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29617	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GTGGGATGGGGTTTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29618	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29619	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29620	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29621	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29622	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29623	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29624	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29625	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29626	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29627	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29628	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29629	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29630	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29631	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29632	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29633	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29634	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29635	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29636	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29637	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29638	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29639	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29640	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29641	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29642	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29643	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29644	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				CTTATCGGAGCACTACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29645	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29646	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29647	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29648	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29649	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29650	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29651	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29652	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29653	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29654	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29655	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29656	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29657	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29658	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29659	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29660	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29661	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29662	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29663	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29664	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29665	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29666	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29667	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29668	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29669	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29670	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29671	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				AGGAGAATCGTGGGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29672	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29673	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29674	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29675	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29676	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29677	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29678	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29679	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29680	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29681	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29682	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29683	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29684	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29685	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29686	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29687	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29688	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29689	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29690	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29691	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29692	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29693	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29694	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29695	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29696	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29697	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29698	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				TGTGTCCTTAGCAGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29699	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29700	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29701	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29702	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29703	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29704	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29705	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29706	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29707	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29708	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29709	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29710	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29711	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29712	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29713	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29714	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29715	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29716	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29717	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29718	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29719	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29720	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29721	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29722	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29723	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29724	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29725	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GGCGTGTCCCAGAAACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29726	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29727	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29728	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29729	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29730	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29731	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29732	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29733	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29734	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29735	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29736	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29737	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29738	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29739	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29740	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29741	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29742	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29743	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29744	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29745	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29746	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29747	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29748	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29749	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29750	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29751	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29752	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GCGCATCCGGACAGGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29753	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29754	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29755	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29756	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29757	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29758	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29759	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29760	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29761	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29762	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29763	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29764	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29765	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29766	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29767	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29768	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29769	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29770	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29771	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29772	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29773	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29774	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29775	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29776	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29777	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29778	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29779	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GTGACTCACCGGGTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29780	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29781	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29782	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29783	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29784	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29785	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29786	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29787	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29788	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29789	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29790	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29791	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29792	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29793	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29794	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29795	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29796	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29797	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29798	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29799	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29800	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29801	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29802	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29803	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29804	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29805	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29806	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GGGCTGACAGTAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29807	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29808	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29809	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29810	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29811	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29812	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29813	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29814	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29815	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29816	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29817	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29818	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29819	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29820	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29821	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29822	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29823	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29824	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29825	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29826	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29827	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29828	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29829	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29830	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29831	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29832	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29833	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GGGAGTCTAAAGAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29834	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29835	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29836	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29837	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29838	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29839	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29840	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29841	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29842	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29843	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29844	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29845	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29846	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29847	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29848	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29849	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29850	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29851	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29852	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29853	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29854	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29855	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29856	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29857	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29858	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29859	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29860	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				TCCCCTGAGAGAGGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29861	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29862	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29863	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29864	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29865	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29866	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29867	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29868	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29869	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29870	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29871	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29872	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29873	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29874	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29875	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29876	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29877	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29878	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29879	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29880	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29881	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29882	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29883	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29884	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29885	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29886	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29887	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GATATTGTGGTTGGGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29888	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29889	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29890	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29891	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29892	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29893	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29894	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29895	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29896	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29897	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29898	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29899	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29900	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29901	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29902	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29903	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29904	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29905	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29906	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29907	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29908	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29909	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29910	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29911	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29912	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29913	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29914	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				GGATGACCCCCAAATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29915	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29916	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29917	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29918	hg19	N/A	enh85978	N/A	Enhatls12345	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29919	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29920	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29921	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29922	hg19	N/A	enh85978	N/A	Enhatls12346	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29923	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29924	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29925	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29926	hg19	N/A	enh85978	N/A	Enhatls12347	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29927	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PMF1-BGLAP	chr1	156212981	156243332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29928	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					BGLAP	chr1	156242183	156243317	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29929	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29930	hg19	N/A	enh85978	N/A	Enhatls12348	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29931	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29932	hg19	N/A	enh85978	N/A	Enhatls12349	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29933	hg19	N/A	enh85978	N/A	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29934	hg19	N/A	enh85978	N/A	Enhatls12350	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11099	chr1	156210811	156224287	156241020	156254496	29935	hg19	N/A	N/A	N/A	Enhatls12350	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11098
enhrx-11100	chr1	156210811	156224287	156241020	156254496	29936	hg19	N/A	N/A	N/A	Enhatls12351	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11099
enhrx-11101	chr1	156210811	156224287	156241020	156254496	29937	hg19	N/A	N/A	N/A	Enhatls12352	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11100
enhrx-11102	chr1	156210811	156224287	156241020	156254496	29938	hg19	N/A	N/A	N/A	Enhatls12353	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11101
enhrx-11103	chr1	156210811	156224287	156241020	156254496	29939	hg19	N/A	N/A	N/A	Enhatls12354	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11102
enhrx-11104	chr1	156210811	156224287	156241020	156254496	29940	hg19	N/A	N/A	fant3252	N/A	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					PAQR6	chr1	156243319	156248117	365				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11103
enhrx-11105	chr1	156210811	156224287	156241020	156254496	29941	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_76				CAATAGGGCGAGGAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29942	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				GGACAGTGCGGAGAGATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29943	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				GGACAGTGCGGAGAGATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29944	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				GGACAGTGCGGAGAGATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29945	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				GGACAGTGCGGAGAGATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29946	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				GGACAGTGCGGAGAGATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29947	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				TGGACACATAAGAGCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29948	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				TGGACACATAAGAGCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29949	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				TGGACACATAAGAGCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29950	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				TGGACACATAAGAGCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29951	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				TGGACACATAAGAGCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29952	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				TACCTGCTAAGACTTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29953	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				TACCTGCTAAGACTTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29954	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				TACCTGCTAAGACTTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29955	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				TACCTGCTAAGACTTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29956	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				TACCTGCTAAGACTTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29957	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				AGTCAATTCTCAATGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29958	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				AGTCAATTCTCAATGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29959	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				AGTCAATTCTCAATGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29960	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				AGTCAATTCTCAATGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29961	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				AGTCAATTCTCAATGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29962	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				GTGCTCCCTAGGGAATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29963	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				GTGCTCCCTAGGGAATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29964	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				GTGCTCCCTAGGGAATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29965	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				GTGCTCCCTAGGGAATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29966	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				GTGCTCCCTAGGGAATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29967	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				GTTGTGGTGGGAAACCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29968	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				GTTGTGGTGGGAAACCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29969	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				GTTGTGGTGGGAAACCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29970	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				GTTGTGGTGGGAAACCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29971	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				GTTGTGGTGGGAAACCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29972	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CCATTAACCTCCTTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29973	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CCATTAACCTCCTTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29974	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CCATTAACCTCCTTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29975	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CCATTAACCTCCTTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29976	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CCATTAACCTCCTTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29977	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				AAGAAAGGAGGGTAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29978	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				AAGAAAGGAGGGTAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29979	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				AAGAAAGGAGGGTAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29980	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				AAGAAAGGAGGGTAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29981	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				AAGAAAGGAGGGTAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29982	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				GATTCAGCAACACAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29983	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				GATTCAGCAACACAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29984	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				GATTCAGCAACACAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29985	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				GATTCAGCAACACAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29986	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				GATTCAGCAACACAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29987	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CCTTCAGCTAGAGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29988	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CCTTCAGCTAGAGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29989	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CCTTCAGCTAGAGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29990	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CCTTCAGCTAGAGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29991	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CCTTCAGCTAGAGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29992	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				AGCCACATCCTTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29993	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				AGCCACATCCTTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29994	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				AGCCACATCCTTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	29995	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				AGCCACATCCTTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	29996	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				AGCCACATCCTTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	29997	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				GTATGGGCACATGGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	29998	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				GTATGGGCACATGGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	29999	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				GTATGGGCACATGGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30000	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				GTATGGGCACATGGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30001	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				GTATGGGCACATGGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30002	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CAGTCATTAGTCATTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30003	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CAGTCATTAGTCATTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30004	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CAGTCATTAGTCATTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30005	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CAGTCATTAGTCATTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30006	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CAGTCATTAGTCATTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30007	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				TCAGGGCCAGGTGCACCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30008	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				TCAGGGCCAGGTGCACCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30009	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				TCAGGGCCAGGTGCACCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30010	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				TCAGGGCCAGGTGCACCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30011	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				TCAGGGCCAGGTGCACCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30012	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CTTGAACTTCTAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30013	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CTTGAACTTCTAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30014	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CTTGAACTTCTAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30015	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CTTGAACTTCTAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30016	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CTTGAACTTCTAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30017	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				TGTGAAGATGTACTAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30018	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				TGTGAAGATGTACTAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30019	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				TGTGAAGATGTACTAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30020	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				TGTGAAGATGTACTAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30021	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				TGTGAAGATGTACTAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30022	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				ATACCAAAGAATCCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30023	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				ATACCAAAGAATCCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30024	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				ATACCAAAGAATCCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30025	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				ATACCAAAGAATCCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30026	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				ATACCAAAGAATCCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30027	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CCGGCATTACTCATAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30028	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CCGGCATTACTCATAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30029	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CCGGCATTACTCATAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30030	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CCGGCATTACTCATAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30031	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CCGGCATTACTCATAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11105	chr1	156227663	156233806	156257872	156264015	30032	hg19	N/A	N/A	N/A	Enhatls12355	enhancer	E_77				CATAAGGGCCCAGCACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11104
enhrx-11106	chr1	156227663	156233806	156257872	156264015	30033	hg19	N/A	N/A	N/A	Enhatls12356	enhancer	E_77				CATAAGGGCCCAGCACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11105
enhrx-11107	chr1	156227663	156233806	156257872	156264015	30034	hg19	N/A	N/A	N/A	Enhatls12357	enhancer	E_77				CATAAGGGCCCAGCACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11106
enhrx-11108	chr1	156227663	156233806	156257872	156264015	30035	hg19	N/A	N/A	N/A	Enhatls12358	enhancer	E_77				CATAAGGGCCCAGCACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11107
enhrx-11109	chr1	156227663	156233806	156257872	156264015	30036	hg19	N/A	N/A	N/A	Enhatls12359	enhancer	E_77				CATAAGGGCCCAGCACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11108
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30037	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				GTTTGGAGGGAAGCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30038	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				GTTTGGAGGGAAGCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30039	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				GGTCCCGTAGTAACTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30040	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				GGTCCCGTAGTAACTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30041	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				GGGGCCCGGGTGTCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30042	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				GGGGCCCGGGTGTCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30043	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				GGCGTGAGAGCAGCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30044	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				GGCGTGAGAGCAGCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30045	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				CTCATGGTGCCCGGGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30046	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				CTCATGGTGCCCGGGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30047	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				TGGCGGCCGAGCAGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30048	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				TGGCGGCCGAGCAGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30049	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				CCGCCTGCCAAATCTCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30050	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				CCGCCTGCCAAATCTCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30051	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				AGTTCTGGCAACTTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30052	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				AGTTCTGGCAACTTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30053	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				TAAAGTTTTTCGCAAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30054	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				TAAAGTTTTTCGCAAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30055	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				GGACAGTGTACCCACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30056	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				GGACAGTGTACCCACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30057	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				AAAGAGGCTTGGCTCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30058	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				AAAGAGGCTTGGCTCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30059	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				TGTTTAAATTATGGGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30060	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				TGTTTAAATTATGGGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11117	chr1	156248308	156256585	156278517	156286794	30061	hg19	N/A	N/A	fant3253	N/A	enhancer	E_78				ATCACATAGGAGTAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11116
enhrx-11118	chr1	156248308	156256585	156278517	156286794	30062	hg19	N/A	N/A	fant3254	N/A	enhancer	E_78				ATCACATAGGAGTAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					SMG5	chr1	156249223	156282825	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11117
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30063	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				CTGAGAGCCACCCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30064	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				CTGAGAGCCACCCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30065	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				CTGAGAGCCACCCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30066	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				TATGGGCTCAGGGCCAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30067	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				TATGGGCTCAGGGCCAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30068	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				TATGGGCTCAGGGCCAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30069	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				GGATCACTCAGAAATGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30070	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				GGATCACTCAGAAATGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30071	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				GGATCACTCAGAAATGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30072	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				CAGGGAGACACCAATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30073	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				CAGGGAGACACCAATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30074	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				CAGGGAGACACCAATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30075	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				TTGCTGCCATTCTATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30076	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				TTGCTGCCATTCTATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30077	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				TTGCTGCCATTCTATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30078	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				TGGATTAGCAGTCAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30079	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				TGGATTAGCAGTCAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30080	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				TGGATTAGCAGTCAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30081	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				TTTGAGGAGCGTGTGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30082	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				TTTGAGGAGCGTGTGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30083	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				TTTGAGGAGCGTGTGTCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30084	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				AATCAAGACCAAGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30085	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				AATCAAGACCAAGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30086	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				AATCAAGACCAAGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30087	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				CCGAGAGGAACTCCAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30088	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				CCGAGAGGAACTCCAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30089	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				CCGAGAGGAACTCCAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30090	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				AGGGGTCTGGTCCCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30091	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				AGGGGTCTGGTCCCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30092	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				AGGGGTCTGGTCCCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	indirect	Non Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11300	chr1	156915659	156917207	156945867	156947415	30093	hg19	N/A	N/A	N/A	Enhatls12576	enhancer	E_80				AGAAGTTTGGAGCCATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11299
enhrx-11301	chr1	156915659	156917207	156945867	156947415	30094	hg19	N/A	N/A	N/A	Enhatls12577	enhancer	E_80				AGAAGTTTGGAGCCATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11300
enhrx-11302	chr1	156915659	156917207	156945867	156947415	30095	hg19	N/A	N/A	N/A	Enhatls12578	enhancer	E_80				AGAAGTTTGGAGCCATACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF2	direct	Highly Significant	NA					ARHGEF11	chr1	156934839	157045742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11301
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30096	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				AGGGGACAGTATGTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30097	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				AGGGGACAGTATGTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30098	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				CTACAGATCAAGGACAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30099	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				CTACAGATCAAGGACAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30100	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				TACGTAAGATAGAACATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30101	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				TACGTAAGATAGAACATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30102	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				TGGGCGGATCATGAGGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30103	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				TGGGCGGATCATGAGGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30104	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				GTGAAGCTGATGCTGTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30105	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				GTGAAGCTGATGCTGTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30106	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				TGTGTACCTTCCTCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30107	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				TGTGTACCTTCCTCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30108	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				TCTGCCTTGAGATAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30109	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				TCTGCCTTGAGATAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30110	hg19	N/A	enh67134	N/A	Enhatls13073	enhancer	E_82				CCTAGGCTCCTTTGTACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11790	chr1	160963730	160970131	160993940	161000341	30111	hg19	N/A	N/A	N/A	Enhatls13073	enhancer	E_82				CCTAGGCTCCTTTGTACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					F11R	chr1	160995210	161021343	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11789
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30112	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30113	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30114	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30115	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30116	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30117	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				CATATGGCTATTAAAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	indirect	Non Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30118	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30119	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30120	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30121	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30122	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30123	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GACCAATCTTGACCTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30124	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30125	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30126	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30127	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30128	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30129	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GACCCGGATAAAGTGGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30130	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30131	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30132	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30133	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30134	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30135	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				CATATATTTGGAGTAATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30136	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30137	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30138	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30139	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30140	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30141	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				ACAACCAGTCTTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30142	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30143	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30144	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30145	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30146	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30147	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TGTGTTGACTGGCATAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30148	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30149	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30150	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30151	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30152	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30153	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TTTGATGCTACTGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30154	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30155	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30156	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30157	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30158	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30159	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TGCTTCTTCTGTGGGTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30160	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30161	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30162	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30163	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30164	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30165	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TTTCCTGATAAGACTAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30166	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30167	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30168	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30169	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30170	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30171	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GTGCGATCACAGCTCACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30172	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30173	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30174	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30175	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30176	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30177	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				CTACAGGCGTAGTCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30178	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30179	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30180	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30181	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30182	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30183	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GTGGAATAAATAACCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30184	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30185	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30186	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30187	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30188	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30189	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				CCTTTGGGGGAGCTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30190	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30191	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30192	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30193	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30194	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30195	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TCCTGGAGCACGTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30196	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30197	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30198	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30199	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30200	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30201	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				AGGCCAACAACAATGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30202	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30203	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30204	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30205	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30206	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30207	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TGGGGCCTTCCTCCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30208	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30209	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30210	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30211	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30212	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30213	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GTGGGCGTGGACTGCTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30214	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30215	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30216	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30217	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30218	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30219	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				CGCATGCTAAGCAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30220	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30221	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30222	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30223	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30224	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30225	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GATTGAGCAAGGGGGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30226	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30227	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30228	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30229	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30230	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30231	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				GGCAATGCGGTAAAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30232	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5733				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30233	hg19	N/A	N/A	fant3464	Enhatls13166	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11885	chr1	161466897	161477694	161497107	161507904	30234	hg19	N/A	N/A	N/A	Enhatls13166	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	5020				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11884
enhrx-11886	chr1	161466897	161477694	161497107	161507904	30235	hg19	N/A	N/A	N/A	Enhatls13167	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11885
enhrx-11887	chr1	161466897	161477694	161497107	161507904	30236	hg19	N/A	N/A	N/A	Enhatls13168	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11886
enhrx-11888	chr1	161466897	161477694	161497107	161507904	30237	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_83				TGGGAGTGTAGAATTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30238	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				GCTCAAGCTCTTAAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30239	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				GCTCAAGCTCTTAAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30240	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				GCTCAAGCTCTTAAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30241	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				GCTCAAGCTCTTAAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30242	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				GTTCAGCTGTGCTTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30243	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				GTTCAGCTGTGCTTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30244	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				GTTCAGCTGTGCTTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30245	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				GTTCAGCTGTGCTTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30246	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				TTTGGCCCTGGTGTGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30247	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				TTTGGCCCTGGTGTGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30248	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				TTTGGCCCTGGTGTGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30249	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				TTTGGCCCTGGTGTGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30250	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				TTGTGTGGTTCTGTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30251	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				TTGTGTGGTTCTGTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30252	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				TTGTGTGGTTCTGTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30253	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				TTGTGTGGTTCTGTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30254	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				CTGGGTTGCTGGAATTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30255	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				CTGGGTTGCTGGAATTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30256	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				CTGGGTTGCTGGAATTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30257	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				CTGGGTTGCTGGAATTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30258	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				TTGCTGCAGAATTTACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30259	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				TTGCTGCAGAATTTACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30260	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				TTGCTGCAGAATTTACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30261	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				TTGCTGCAGAATTTACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11888	chr1	161479228	161484287	161509438	161514497	30262	hg19	N/A	N/A	N/A	Enhatls13169	enhancer	E_84				CAGTTTATGACAAAAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11887
enhrx-11889	chr1	161479228	161484287	161509438	161514497	30263	hg19	N/A	N/A	N/A	Enhatls13170	enhancer	E_84				CAGTTTATGACAAAAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11888
enhrx-11890	chr1	161479228	161484287	161509438	161514497	30264	hg19	N/A	N/A	N/A	Enhatls13171	enhancer	E_84				CAGTTTATGACAAAAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11889
enhrx-11891	chr1	161479228	161484287	161509438	161514497	30265	hg19	N/A	N/A	N/A	Enhatls13172	enhancer	E_84				CAGTTTATGACAAAAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCGR2A	chr1	161505429	161519967	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11890
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30266	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				TGGGTGTTATGATGACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30267	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				CATGGGCCCTACCATTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30268	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				GGAGGCCATCTGGAACGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30269	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				CCGATATCTTGAGAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30270	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				TCTAATTTCCTCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30271	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				CTAAGTCTGCTCAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30272	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				GACTAATCTGATATCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30273	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				ATATAAGTGTTGGAATGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30274	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				TGCATCACCAGTGAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30275	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				AATTTACTCACAGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30276	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				AGATGATGCTGAAAGCGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30277	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				GAAAACAGACCCCAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30278	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				TTCCTCTTTTCTAATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-11917	chr1	161674637	161677964	161704847	161708174	30279	hg19	N/A	N/A	N/A	Enhatls13201	enhancer	E_85				GCACACCAAGGGAAAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	USF1	direct	Highly Significant	NA					FCRLA	chr1	161706971	161714352	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11916
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30280	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AAATGAGTGAACCGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30281	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AAATGAGTGAACCGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30282	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AAATGAGTGAACCGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30283	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AAATGAGTGAACCGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30284	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GTATGTGTCCTACTTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30285	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GTATGTGTCCTACTTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30286	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GTATGTGTCCTACTTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30287	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GTATGTGTCCTACTTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30288	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGTGGACTAGACAATAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30289	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGTGGACTAGACAATAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30290	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGTGGACTAGACAATAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30291	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGTGGACTAGACAATAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30292	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				ATGATGGACCCGAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30293	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				ATGATGGACCCGAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30294	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				ATGATGGACCCGAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30295	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				ATGATGGACCCGAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30296	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGCCGTAGACTATAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30297	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGCCGTAGACTATAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30298	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGCCGTAGACTATAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30299	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGCCGTAGACTATAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30300	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGCATCTTGCCACTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30301	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GGCATCTTGCCACTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30302	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGCATCTTGCCACTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30303	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GGCATCTTGCCACTTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30304	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				TGGTAAAAAGAGGACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30305	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				TGGTAAAAAGAGGACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30306	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				TGGTAAAAAGAGGACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30307	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				TGGTAAAAAGAGGACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30308	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GACATTTCTTTAACGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30309	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				GACATTTCTTTAACGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30310	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GACATTTCTTTAACGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30311	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				GACATTTCTTTAACGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30312	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				CTTCTGTCATAAATCATAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30313	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				CTTCTGTCATAAATCATAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30314	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				CTTCTGTCATAAATCATAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30315	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				CTTCTGTCATAAATCATAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30316	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AGAATGATAAATTCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30317	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AGAATGATAAATTCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30318	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AGAATGATAAATTCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30319	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AGAATGATAAATTCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30320	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AGCCTTTTGACACAGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30321	hg19	N/A	enh12346	N/A	N/A	enhancer	E_87				AGCCTTTTGACACAGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30322	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AGCCTTTTGACACAGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167062959	167065282	167093722	167096045	30323	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_87				AGCCTTTTGACACAGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30324	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTCCAGGGCAGAATGGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30325	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTCCAGGGCAGAATGGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30326	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CTGCCACTACCCCACTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30327	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CTGCCACTACCCCACTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30328	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				ATTTAGGCAGCCGGTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30329	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				ATTTAGGCAGCCGGTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30330	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTGGGGGTAAAGCTGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30331	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTGGGGGTAAAGCTGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30332	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				AGAGGCAACCACAATCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30333	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				AGAGGCAACCACAATCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30334	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CCGACAGCAAGCCCCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30335	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CCGACAGCAAGCCCCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30336	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GGTCTTCTGGATAAATATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30337	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GGTCTTCTGGATAAATATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	direct	Highly Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30338	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CGCAGCTGATGCATTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30339	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				CGCAGCTGATGCATTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30340	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GAACAATGCTGCTCTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30341	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GAACAATGCTGCTCTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30342	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTAGCAGTGAAGTTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					GPA33	chr1	167052835	167166479	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-12153	chr1	167077185	167079661	167107948	167110424	30343	hg19	N/A	enh12346	N/A	Enhatls13454	enhancer	E_88				GTAGCAGTGAAGTTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA1	indirect	Non Significant	NA					STYXL2	chr1	167094074	167129165	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12152
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30344	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30345	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30346	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30347	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30348	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30349	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30350	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30351	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30352	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30353	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30354	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GACTTTGTGGGGTTAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30355	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30356	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30357	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30358	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30359	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30360	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30361	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30362	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30363	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30364	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30365	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GGTCAAAGTTCTGCAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30366	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30367	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30368	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30369	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30370	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30371	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30372	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30373	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30374	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30375	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30376	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GCTCTAGGAGACGTCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30377	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30378	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30379	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30380	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30381	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30382	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30383	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30384	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30385	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30386	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30387	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GTTCTTACAAGAACCTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30388	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30389	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30390	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30391	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30392	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30393	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30394	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30395	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30396	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30397	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30398	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GGAGCATGCTGAAGTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30399	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30400	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30401	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30402	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30403	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30404	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30405	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30406	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30407	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30408	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30409	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				TCACCTCCTTGGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30410	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30411	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30412	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30413	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30414	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30415	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30416	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30417	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30418	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30419	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30420	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				ATTCTATCCCTCACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30421	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30422	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30423	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30424	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30425	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30426	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30427	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30428	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30429	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30430	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30431	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				TCCTTCAACCCCAATCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30432	hg19	N/A	enh12556	N/A	Enhatls15956	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30433	hg19	N/A	enh12556	N/A	N/A	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30434	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30435	hg19	N/A	enh12556	fant4377	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	3909				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30436	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	4458				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30437	hg19	N/A	enh12556	fant4378	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11508				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30438	hg19	N/A	enh12556	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	11665				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30439	hg19	N/A	N/A	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	19919				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30440	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	23129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30441	hg19	N/A	enh12557	fant4379	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203474255	203508314	203505127	203539186	30442	hg19	N/A	enh12557	N/A	Enhatls15957	enhancer	E_89				GAGAGAAGAAGCCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	28428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30443	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGGATTGAGAAAAATTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30444	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AGGATTGAGAAAAATTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30445	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGGATTGAGAAAAATTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30446	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AGGATTGAGAAAAATTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30447	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGGATTGAGAAAAATTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30448	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGAGGGCAACCGTAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30449	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AGAGGGCAACCGTAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30450	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGAGGGCAACCGTAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30451	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AGAGGGCAACCGTAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30452	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGAGGGCAACCGTAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30453	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GATGAAGCTGTTCAGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30454	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				GATGAAGCTGTTCAGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30455	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GATGAAGCTGTTCAGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30456	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				GATGAAGCTGTTCAGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30457	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GATGAAGCTGTTCAGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30458	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCTAGGGAGTCTCCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30459	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				GCTAGGGAGTCTCCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30460	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCTAGGGAGTCTCCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30461	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				GCTAGGGAGTCTCCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30462	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCTAGGGAGTCTCCAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30463	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				ATTGAACAGTTACTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30464	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				ATTGAACAGTTACTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30465	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				ATTGAACAGTTACTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30466	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				ATTGAACAGTTACTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30467	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				ATTGAACAGTTACTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30468	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CGACCTCTCAGGCCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30469	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				CGACCTCTCAGGCCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30470	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CGACCTCTCAGGCCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30471	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				CGACCTCTCAGGCCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30472	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CGACCTCTCAGGCCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30473	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGTAAGCGGCAGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30474	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AAGTAAGCGGCAGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30475	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGTAAGCGGCAGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30476	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AAGTAAGCGGCAGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30477	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGTAAGCGGCAGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30478	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CATTGTTACACAATGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30479	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				CATTGTTACACAATGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30480	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CATTGTTACACAATGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30481	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				CATTGTTACACAATGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30482	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CATTGTTACACAATGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30483	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGCAAATCAAGGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30484	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AAGCAAATCAAGGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30485	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGCAAATCAAGGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30486	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AAGCAAATCAAGGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30487	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AAGCAAATCAAGGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30488	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GAGCCAAGATGAACATAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30489	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				GAGCCAAGATGAACATAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30490	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GAGCCAAGATGAACATAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30491	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				GAGCCAAGATGAACATAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30492	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GAGCCAAGATGAACATAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30493	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCGGATTGGAACCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30494	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				CCGGATTGGAACCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30495	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCGGATTGGAACCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30496	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				CCGGATTGGAACCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30497	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCGGATTGGAACCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30498	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AATTTTAGAGACAAGGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30499	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AATTTTAGAGACAAGGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30500	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AATTTTAGAGACAAGGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30501	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AATTTTAGAGACAAGGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30502	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AATTTTAGAGACAAGGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30503	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCTGCTCCAAGCACACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30504	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				CCTGCTCCAAGCACACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30505	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCTGCTCCAAGCACACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30506	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				CCTGCTCCAAGCACACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30507	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				CCTGCTCCAAGCACACTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30508	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GGCCATCTCTCTGGGCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30509	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				GGCCATCTCTCTGGGCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30510	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GGCCATCTCTCTGGGCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30511	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				GGCCATCTCTCTGGGCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30512	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GGCCATCTCTCTGGGCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30513	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGCTCTTTCTCTGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30514	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				AGCTCTTTCTCTGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30515	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGCTCTTTCTCTGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30516	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				AGCTCTTTCTCTGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30517	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				AGCTCTTTCTCTGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30518	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCATCTTCTGTGCTGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	33585				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30519	hg19	N/A	enh12558	fant4380	Enhatls15957	enhancer	E_90				GCATCTTCTGTGCTGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	46863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30520	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCATCTTCTGTGCTGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	47488				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30521	hg19	N/A	enh12558	fant4381	Enhatls15957	enhancer	E_90				GCATCTTCTGTGCTGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14497	chr1	203520389	203530365	203551261	203561237	30522	hg19	N/A	enh12558	N/A	Enhatls15957	enhancer	E_90				GCATCTTCTGTGCTGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					OPTC	chr1	203494152	203508949	48777				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14496
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30523	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				TATCGCTAAGATAACTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30524	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				TTATTTAAGTCACTAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30525	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				GTGGGTCAGGAATTTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30526	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				TTTCATGAAACTATTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30527	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				GTAGAAAGACCCACATGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30528	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				GAGCTGCTTGATATGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30529	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				GTTACAATGCGGGATGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30530	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				ATTAGAAGTGAGTCATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30531	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				TCACTTGAGATCAGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30532	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				AGATCTTGCCATTGCACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30533	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				AATGAAAAGGGATTACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30534	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				TCAGCCCATAAAGATATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-14542	chr1	204025980	204028049	204056852	204058921	30535	hg19	N/A	enh27429	N/A	Enhatls16008	enhancer	E_93				ACAGTGCTGTGTGGAAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					SOX13	chr1	204073114	204127743	11888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14541
enhrx-lit651	chr1	204168051	204168990	204198923	204199862	30536	hg19					enhancer	E_94				GAATCATTACTCCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit652	chr1	204168051	204168990	204198923	204199862	30537	hg19					enhancer	E_94				TGCCAGGCGCAGATACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit653	chr1	204168051	204168990	204198923	204199862	30538	hg19					enhancer	E_94				TGTGGTGGGGTGCTGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit654	chr1	204168051	204168990	204198923	204199862	30539	hg19					enhancer	E_94				AGGAAAAGCTGTCCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit655	chr1	204168051	204168990	204198923	204199862	30540	hg19					enhancer	E_94				TCTGGCTAAGTGCGGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit656	chr1	204168051	204168990	204198923	204199862	30541	hg19					enhancer	E_94				GTAGCTGAGTGTGGCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit657	chr1	204168051	204168990	204198923	204199862	30542	hg19					enhancer	E_94				TGTCAAATGGAGAAGGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit658	chr1	204168051	204168990	204198923	204199862	30543	hg19					enhancer	E_94				GCGTACCCTGGGGAGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit659	chr1	204168051	204168990	204198923	204199862	30544	hg19					enhancer	E_94				GGATGTTGCAGACATTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30545	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				TGCTGGAGAGGTAAAAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30546	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				GAGGGTAGATAGATGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30547	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				TGTCACAGCCCAACCCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30548	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				ACTCTCCATTCCCCTGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30549	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				GGGCTTCTTCCCGAGAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30550	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				TTGCTGGGGTCGTCATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30551	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				AGGGCTCCCAGGATATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14587	chr1	204351512	204352161	204382384	204383033	30552	hg19	N/A	enh87666	N/A	Enhatls16060	enhancer	E_95				GCACATATAGCTGGAAATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					PLEKHA6	chr1	204218852	204377665	3593				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14586
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30553	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				TCCTTCCTTGCAGCCTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30554	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				TCCTTCCTTGCAGCCTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30555	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				TGTGAAGCTGGCTTGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30556	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				TGTGAAGCTGGCTTGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30557	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				AAATGCTGCCAGATGACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30558	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				AAATGCTGCCAGATGACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30559	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				ACTCCACTAGAGGGGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30560	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				ACTCCACTAGAGGGGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30561	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				GTATCTCTGGAGACACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30562	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				GTATCTCTGGAGACACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30563	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				TGTCTGGCACCTCACATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30564	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				TGTCTGGCACCTCACATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30565	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				AATTGCATGTCTAAATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30566	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				AATTGCATGTCTAAATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30567	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				GTCTGGTGCTTTCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30568	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				GTCTGGTGCTTTCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30569	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				ACTGATGCTCTCCTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30570	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				ACTGATGCTCTCCTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30571	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				CTGCGTCACCCCGGGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30572	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				CTGCGTCACCCCGGGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30573	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				CTGGTTGTGTGACTCACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30574	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				CTGGTTGTGTGACTCACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30575	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				ATAAACTTCCCGAGTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30576	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				ATAAACTTCCCGAGTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30577	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				TGTGTCTGTCACCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30578	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				TGTGTCTGTCACCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30579	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				GTATTGGGGTGCACATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30580	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				GTATTGGGGTGCACATAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30581	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				GAGAATGTTCTGCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30582	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				GAGAATGTTCTGCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30583	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				AAAATTCAAGAATTTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30584	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				AAAATTCAAGAATTTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14645	chr1	204958325	204960785	204989197	204991657	30585	hg19	N/A	N/A	N/A	Enhatls16133	enhancer	E_97				CTAACTTCATAAAGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14644
enhrx-14646	chr1	204958325	204960785	204989197	204991657	30586	hg19	N/A	N/A	N/A	Enhatls16134	enhancer	E_97				CTAACTTCATAAAGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NFASC	chr1	204828651	205022822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14645
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30587	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				TTCACCATGTTGGCCAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30588	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				TGATATTGAGTCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30589	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				AGGTACCCTGACCAATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30590	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				TAAATCATAATAGGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30591	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				ATGAGCTACCTTATACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30592	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				CAAAAGCTTGTTGAGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30593	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				GCTGCGTCAGGTCTTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30594	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				TCTCCAGTAATGTAACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30595	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				AGTAGCAGCCCAATCTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14669	chr1	205058293	205061286	205089165	205092158	30596	hg19	N/A	N/A	N/A	Enhatls16157	enhancer	E_98				GGGATGTTATTAACTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					RBBP5	chr1	205086141	205122015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14668
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30597	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				GTGAGATATTTGTGCTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30598	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTGAGATATTTGTGCTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30599	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				GTGAGATATTTGTGCTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30600	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTGAGATATTTGTGCTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30601	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				GAGCTTTAGGGAGTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30602	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GAGCTTTAGGGAGTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30603	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				GAGCTTTAGGGAGTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30604	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GAGCTTTAGGGAGTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30605	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				CATCTGTGTCTCAAGTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30606	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				CATCTGTGTCTCAAGTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30607	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				CATCTGTGTCTCAAGTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30608	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				CATCTGTGTCTCAAGTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30609	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				GTGTGACTCAGGGTAGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30610	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTGTGACTCAGGGTAGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30611	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				GTGTGACTCAGGGTAGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30612	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTGTGACTCAGGGTAGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30613	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				GTCAGGCATATTCAAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30614	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTCAGGCATATTCAAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30615	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				GTCAGGCATATTCAAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30616	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GTCAGGCATATTCAAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30617	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				ACAATGAGATAAAGACTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30618	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				ACAATGAGATAAAGACTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30619	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				ACAATGAGATAAAGACTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30620	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				ACAATGAGATAAAGACTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30621	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				TGGGGTGGGCAGATCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30622	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TGGGGTGGGCAGATCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30623	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				TGGGGTGGGCAGATCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30624	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TGGGGTGGGCAGATCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30625	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				TACAAGGTATATTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30626	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TACAAGGTATATTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30627	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				TACAAGGTATATTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30628	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TACAAGGTATATTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30629	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				ACATGTTGGTCAACTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30630	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				ACATGTTGGTCAACTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30631	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				ACATGTTGGTCAACTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30632	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				ACATGTTGGTCAACTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30633	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				GCCTAATTCGTACTGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30634	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GCCTAATTCGTACTGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30635	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				GCCTAATTCGTACTGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30636	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				GCCTAATTCGTACTGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30637	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				AAGGGATGACTCATGCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30638	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				AAGGGATGACTCATGCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30639	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				AAGGGATGACTCATGCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30640	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				AAGGGATGACTCATGCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30641	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				AGGATGAGCCAGAGCTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30642	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				AGGATGAGCCAGAGCTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30643	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				AGGATGAGCCAGAGCTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30644	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				AGGATGAGCCAGAGCTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30645	hg19	N/A	enh12587	N/A	N/A	enhancer	E_99				TTGGATGCTTACTAAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30646	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TTGGATGCTTACTAAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30647	hg19	N/A	enh12587	fant4450	Enhatls16175	enhancer	E_99				TTGGATGCTTACTAAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14686	chr1	205138839	205147592	205169711	205178464	30648	hg19	N/A	enh12587	N/A	Enhatls16175	enhancer	E_99				TTGGATGCTTACTAAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14685
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30649	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				TAACATGCTTCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30650	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				CCCAACTCCAAAGAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30651	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				TCTAGGCAGTGTGAGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30652	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				GCACTTCAACCAGAACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30653	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				CTTGACACTTACATGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30654	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				TTACCTCACAGAGCTCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30655	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				CATTCATAACAAGACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30656	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				AATAGCCTCTAGGGATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30657	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				GGAAAACTACGAGCTATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30658	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				ATTATATCATCTCGTTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30659	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				TGCCCACTTTCTGACAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30660	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				TGCAGTGGTGCAATCTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-14687	chr1	205168279	205169616	205199151	205200488	30661	hg19	N/A	N/A	N/A	Enhatls16176	enhancer	E_100				AATCATCTGGTCGCGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					DSTYK	chr1	205142504	205211702	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14686
enhrx-lit660	chr1	205196241	205197729	205227113	205228601	30662	hg19					enhancer	E_101				GCATTTGCAGCTCTGAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit661	chr1	205196241	205197729	205227113	205228601	30663	hg19					enhancer	E_101				TCAGACCAAGTATCCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit662	chr1	205196241	205197729	205227113	205228601	30664	hg19					enhancer	E_101				GAATGGGTGGAGGAAATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit663	chr1	205196241	205197729	205227113	205228601	30665	hg19					enhancer	E_101				ACCGTGCGATCCCCCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit664	chr1	205196241	205197729	205227113	205228601	30666	hg19					enhancer	E_101				GCGACGCCCCCTCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit665	chr1	205196241	205197729	205227113	205228601	30667	hg19					enhancer	E_101				GGTAGGTTGCGCGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit666	chr1	205196241	205197729	205227113	205228601	30668	hg19					enhancer	E_101				GCTGCGCGTCAGGCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit667	chr1	205196241	205197729	205227113	205228601	30669	hg19					enhancer	E_101				GGCTCCGCGGCCGGACCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit668	chr1	205196241	205197729	205227113	205228601	30670	hg19					enhancer	E_101				AGGTCCTAGTCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit669	chr1	205196241	205197729	205227113	205228601	30671	hg19					enhancer	E_101				CACAGCGCATCCCTCCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit670	chr1	205196241	205197729	205227113	205228601	30672	hg19					enhancer	E_101				GCGAAGACAGGTCACAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit671	chr1	205196241	205197729	205227113	205228601	30673	hg19					enhancer	E_101				ACTATTCCAAGCTATAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30674	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				CAAGCAGTCTCTTTTCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30675	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				GTACCCAAGACTCATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30676	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				CCAGGAATGGGCGTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30677	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				GACAGAGCAGGGTTTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30678	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				CTATTCATGCCCAGAGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30679	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				GCTCTCTGCAAGATCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30680	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				TGAGTTCTAAACAATGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30681	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				GTTGAGTTACCGAAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30682	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				TGAGGTCTCCTACTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30683	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				GTGTGACGGGGGACAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14692	chr1	205216273	205216823	205247145	205247695	30684	hg19	N/A	enh12588	N/A	Enhatls16179	enhancer	E_102				TTAAACAGGGAAGTAATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14691
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30685	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGCTCTTGCTGGAATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30686	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				CCTGCTCTTGCTGGAATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30687	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGCTCTTGCTGGAATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30688	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				CCTGCTCTTGCTGGAATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30689	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGCTCTTGCTGGAATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30690	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				TCTCTCCCAACTTTACCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30691	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				TCTCTCCCAACTTTACCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30692	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				TCTCTCCCAACTTTACCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30693	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				TCTCTCCCAACTTTACCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30694	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				TCTCTCCCAACTTTACCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30695	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCATTCTCAGATGGAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30696	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				CCATTCTCAGATGGAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30697	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCATTCTCAGATGGAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30698	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				CCATTCTCAGATGGAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30699	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCATTCTCAGATGGAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30700	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCACTGAAATCAGAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30701	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				CCACTGAAATCAGAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30702	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCACTGAAATCAGAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30703	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				CCACTGAAATCAGAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30704	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCACTGAAATCAGAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30705	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				AGCAGGCGAGTGCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30706	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				AGCAGGCGAGTGCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30707	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				AGCAGGCGAGTGCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30708	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				AGCAGGCGAGTGCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30709	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				AGCAGGCGAGTGCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30710	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGTGCAGAACACCGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30711	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				CCTGTGCAGAACACCGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30712	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGTGCAGAACACCGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30713	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				CCTGTGCAGAACACCGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30714	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				CCTGTGCAGAACACCGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30715	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				GGGCTGCCCTGCTTTCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30716	hg19	N/A	enh27434	fant4457	Enhatls16180	enhancer	E_103				GGGCTGCCCTGCTTTCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30717	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				GGGCTGCCCTGCTTTCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30718	hg19	N/A	enh27434	fant4458	Enhatls16180	enhancer	E_103				GGGCTGCCCTGCTTTCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14693	chr1	205226168	205232554	205257040	205263426	30719	hg19	N/A	enh27434	N/A	Enhatls16180	enhancer	E_103				GGGCTGCCCTGCTTTCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14692
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30720	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30721	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30722	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30723	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30724	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30725	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30726	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30727	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30728	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				AGGTTTAGGAAGGGTGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30729	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30730	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30731	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30732	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30733	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30734	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30735	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30736	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30737	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TCAGTGTGATCACTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30738	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30739	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30740	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30741	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30742	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30743	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30744	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30745	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30746	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				GGCTCAGGATGGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30747	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30748	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30749	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30750	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30751	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30752	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30753	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30754	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30755	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ATGATGGGAAATCAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30756	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30757	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30758	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30759	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30760	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30761	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30762	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30763	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30764	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTTCAGTCGCCCTCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30765	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30766	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30767	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30768	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30769	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30770	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30771	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30772	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30773	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CAGCTTAGCTTGTCCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30774	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30775	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30776	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30777	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30778	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30779	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30780	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30781	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30782	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TTGTGCAACACCACATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30783	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30784	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30785	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30786	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30787	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30788	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30789	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30790	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30791	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				CTCCTTTGTGAAGGAGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30792	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30793	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30794	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30795	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30796	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30797	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30798	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30799	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30800	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				TGACAATGACCACTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30801	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30802	hg19	N/A	enh893	fant4459	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10243				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30803	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	10507				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30804	hg19	N/A	enh893	fant4460	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30805	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	11902				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30806	hg19	N/A	enh893	fant4461	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30807	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					TMCC2	chr1	205227945	205273343	12930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30808	hg19	N/A	enh893	fant4462	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	13425				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205251825	205259454	205282697	205290326	30809	hg19	N/A	enh893	N/A	Enhatls16183	enhancer	E_104				ACATACTTGGTTTTGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	11556				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30810	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30811	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30812	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30813	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30814	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30815	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30816	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30817	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30818	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30819	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30820	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30821	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30822	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30823	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				TTGCTTATCAACAGGCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30824	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30825	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30826	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30827	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30828	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30829	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30830	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30831	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30832	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30833	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30834	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30835	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30836	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30837	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GTGAGCCCGGCCACCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30838	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30839	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30840	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30841	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30842	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30843	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30844	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30845	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30846	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30847	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30848	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30849	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30850	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30851	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				AGGGGTCCCTTAGCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30852	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30853	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30854	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30855	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30856	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30857	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30858	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30859	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30860	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30861	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30862	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30863	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30864	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30865	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CCTTTGTTGTGTCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30866	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30867	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30868	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30869	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30870	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30871	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30872	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30873	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30874	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30875	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30876	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30877	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30878	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30879	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CATGTCCCGCCTGGAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30880	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30881	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30882	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30883	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30884	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30885	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30886	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30887	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30888	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30889	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30890	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30891	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30892	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30893	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				AGAGCTCGAATTCTGATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30894	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30895	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30896	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30897	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30898	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30899	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30900	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30901	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30902	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30903	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30904	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30905	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30906	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30907	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CAGAGCTGAACACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30908	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30909	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30910	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30911	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30912	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30913	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30914	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30915	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30916	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30917	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30918	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30919	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30920	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30921	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CCGGCACTGTCTGTTTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30922	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30923	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30924	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30925	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30926	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30927	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30928	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30929	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30930	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30931	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30932	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30933	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30934	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30935	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				ACCCTCAAAGGAATTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30936	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30937	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30938	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30939	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30940	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30941	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30942	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30943	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30944	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30945	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30946	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30947	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30948	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30949	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GATTTCAGGTTTCCATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30950	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30951	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30952	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30953	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30954	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30955	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30956	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30957	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30958	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30959	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30960	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30961	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30962	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30963	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GGATGAGTCATCCTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30964	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30965	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30966	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30967	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30968	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30969	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30970	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30971	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30972	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30973	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30974	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30975	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30976	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30977	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GTGGGATTAGCTCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30978	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30979	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30980	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30981	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30982	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30983	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30984	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30985	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30986	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30987	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30988	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30989	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	30990	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	30991	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				TCCTCACCATCTCTTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30992	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30993	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30994	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30995	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30996	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30997	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30998	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	30999	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31000	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31001	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31002	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31003	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31004	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31005	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CTAGAAGCTCTACTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31006	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31007	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31008	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31009	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31010	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31011	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31012	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31013	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31014	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31015	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31016	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31017	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31018	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31019	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CAGTGATCCAGAGCACTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31020	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31021	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31022	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31023	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31024	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31025	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31026	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31027	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31028	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31029	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31030	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31031	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31032	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31033	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GCAGTCCTCTGTGTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31034	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31035	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31036	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31037	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31038	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31039	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31040	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31041	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31042	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31043	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31044	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31045	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31046	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31047	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GCAAAGGGCCTTCTGCAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31048	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31049	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31050	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31051	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31052	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31053	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31054	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31055	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31056	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31057	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31058	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31059	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31060	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31061	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				AAGAACCCAGATGATGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31062	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31063	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31064	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31065	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31066	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31067	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31068	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31069	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31070	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31071	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31072	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31073	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31074	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31075	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				ACGTGGGCCCCCAAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31076	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31077	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31078	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31079	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31080	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31081	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31082	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31083	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31084	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31085	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31086	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31087	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31088	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31089	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				TGAAGCATCCAGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31090	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31091	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31092	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31093	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31094	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31095	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31096	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31097	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31098	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31099	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31100	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31101	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31102	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31103	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GTCCCTCATCTAGGTCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31104	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31105	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31106	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31107	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31108	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31109	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31110	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31111	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31112	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31113	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31114	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31115	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31116	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31117	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				ATAAAAAATTAGCCGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31118	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31119	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31120	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31121	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31122	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31123	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31124	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31125	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31126	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31127	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31128	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31129	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31130	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31131	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				ATCATGTTGAAAGGGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31132	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31133	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31134	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31135	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31136	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31137	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31138	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31139	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31140	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31141	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31142	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31143	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31144	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31145	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CAGAGATCTTAGCCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31146	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31147	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31148	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31149	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31150	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31151	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31152	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31153	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31154	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31155	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31156	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31157	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31158	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31159	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				AGAGGTAATTGCTGTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31160	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31161	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31162	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31163	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31164	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31165	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31166	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31167	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31168	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31169	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31170	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31171	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31172	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31173	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				TTCATGAGAGGAATGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31174	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31175	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31176	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31177	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31178	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31179	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31180	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31181	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31182	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31183	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31184	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31185	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31186	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31187	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CTGGAGATAAACCCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31188	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31189	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31190	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31191	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31192	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31193	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31194	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31195	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31196	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31197	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31198	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31199	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31200	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31201	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				ACTTAGGTCTTAAGTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31202	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31203	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31204	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31205	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31206	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31207	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31208	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31209	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31210	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31211	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31212	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31213	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31214	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31215	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				AGGCAACTATGAGGTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31216	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31217	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31218	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31219	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31220	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31221	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31222	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31223	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31224	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31225	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31226	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31227	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31228	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31229	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CAGCTCAGCTCTCCAGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31230	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31231	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31232	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31233	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31234	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31235	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31236	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31237	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31238	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31239	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31240	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31241	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31242	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31243	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GGAGGATGAGGACAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31244	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31245	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31246	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31247	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31248	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31249	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31250	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31251	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31252	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31253	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31254	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31255	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31256	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31257	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GAGAAACTCCCAGGCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31258	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31259	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31260	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31261	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31262	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31263	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31264	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31265	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31266	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31267	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31268	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31269	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31270	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31271	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				TGTGGGGAATGCTCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31272	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31273	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31274	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31275	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31276	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31277	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31278	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31279	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31280	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31281	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31282	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31283	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31284	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31285	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GTCAGGCAGTGAGGACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31286	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31287	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31288	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31289	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31290	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31291	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31292	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31293	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31294	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31295	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31296	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31297	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31298	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31299	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				GTCTTTACGCAGCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31300	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31301	hg19	N/A	enh12589	fant4463	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	8158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31302	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31303	hg19	N/A	enh12589	fant4464	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	7115				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31304	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31305	hg19	N/A	enh12589	fant4465	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	5643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31306	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31307	hg19	N/A	enh12589	fant4466	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	3093				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31308	hg19	N/A	enh12589	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31309	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31310	hg19	N/A	N/A	fant4467	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14696	chr1	205260485	205274527	205291357	205305399	31311	hg19	N/A	N/A	N/A	Enhatls16183	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	1				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14695
enhrx-14697	chr1	205260485	205274527	205291357	205305399	31312	hg19	N/A	N/A	N/A	Enhatls16184	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14696
enhrx-14698	chr1	205260485	205274527	205291357	205305399	31313	hg19	N/A	N/A	N/A	Enhatls16185	enhancer	E_105				CTTTGGCACTAAAGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14697
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31314	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31315	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31316	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31317	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31318	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31319	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACGGACTGACACATCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31320	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31321	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31322	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31323	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31324	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31325	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GCTCCGGCTTGGCCGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31326	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31327	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31328	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31329	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31330	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31331	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GAGAGGGAGCCGCACTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31332	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31333	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31334	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31335	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31336	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31337	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACCACCACAAGCACAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31338	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31339	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31340	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31341	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31342	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31343	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CGCAGAGCTAGCCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31344	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31345	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31346	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31347	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31348	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31349	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GCGACTCCATGGCGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31350	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31351	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31352	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31353	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31354	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31355	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACAGGTCCCGCACCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31356	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31357	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31358	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31359	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31360	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31361	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CCCATTGGCCTGCTCGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31362	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31363	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31364	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31365	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31366	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31367	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				CACCTTTCCCGGCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31368	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31369	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31370	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31371	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31372	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31373	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				GTAAGCTTCTGGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31374	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31375	hg19	N/A	enh12590	fant4470	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31376	hg19	N/A	enh12590	N/A	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31377	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31378	hg19	N/A	N/A	fant4471	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14701	chr1	205285121	205291432	205315993	205322304	31379	hg19	N/A	N/A	N/A	Enhatls16189	enhancer	E_106				ACAGAGTACAATAAAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					NUAK2	chr1	205302062	205321745	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14700
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31380	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				AGCCTGCTCTGAACCTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31381	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				CTGTGCCTCACCACACTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31382	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				CCTGATGGTTAACCCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31383	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				CTGGACCAGGGACAGCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31384	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				GGCAGAACTGTAAATCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31385	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				AGTGGCCATCTGCCGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31386	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				ACCAAGGGAGGCCCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31387	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				GTGGGCAGGGGCACGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31388	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				TTAACCGTCAGAATGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31389	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				TCTAGCTTCCTCATTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31390	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				AAACAGAGCTAATCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31391	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				GTAGTTGCACAGCTCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14721	chr1	205445960	205448476	205476832	205479348	31392	hg19	N/A	enh61954	N/A	Enhatls16210	enhancer	E_107				TCGACCCTGTAGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					BLACAT1	chr1	205434884	205457091	18413				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14720
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31393	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACGGTGCACAGCGTTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31394	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				ACGGTGCACAGCGTTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31395	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACGGTGCACAGCGTTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31396	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACTGTTTTGTTTGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31397	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				ACTGTTTTGTTTGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31398	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACTGTTTTGTTTGCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31399	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GGGCCGTGAGCAGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31400	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				GGGCCGTGAGCAGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31401	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GGGCCGTGAGCAGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31402	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				TTCAGAATGCAGCCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31403	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				TTCAGAATGCAGCCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31404	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				TTCAGAATGCAGCCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31405	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CTGGGAGCGCATGCGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31406	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				CTGGGAGCGCATGCGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31407	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CTGGGAGCGCATGCGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31408	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GGCATGGGAGAACAATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31409	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				GGCATGGGAGAACAATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31410	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GGCATGGGAGAACAATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31411	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				TGAGAGCCTGCCAGGCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31412	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				TGAGAGCCTGCCAGGCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31413	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				TGAGAGCCTGCCAGGCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31414	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				AGCTCTGGCGTTTCTTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31415	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				AGCTCTGGCGTTTCTTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31416	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				AGCTCTGGCGTTTCTTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31417	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CAGGGACCTTGGCAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31418	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				CAGGGACCTTGGCAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31419	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CAGGGACCTTGGCAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	direct	Highly Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31420	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GATGGCTCACACCTGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31421	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				GATGGCTCACACCTGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31422	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GATGGCTCACACCTGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31423	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACTGAGCATTACTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31424	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				ACTGAGCATTACTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31425	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				ACTGAGCATTACTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31426	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CTGGGGGTGCCATCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31427	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				CTGGGGGTGCCATCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31428	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CTGGGGGTGCCATCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31429	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GTAACCTATTTCTTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31430	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				GTAACCTATTTCTTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31431	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				GTAACCTATTTCTTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31432	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CAGACCACGCAGCTACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31433	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				CAGACCACGCAGCTACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31434	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				CAGACCACGCAGCTACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31435	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				AGAAATTCTGTCGCAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	525				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31436	hg19	N/A	enh12593	fant4483	Enhatls16221	enhancer	E_108				AGAAATTCTGTCGCAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-14732	chr1	205512408	205513585	205543280	205544457	31437	hg19	N/A	enh12593	N/A	Enhatls16221	enhancer	E_108				AGAAATTCTGTCGCAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MDM4	indirect	Non Significant	NA					CDK18	chr1	205504597	205532793	10907				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	14731
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31438	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				CCCTTTGTGGTGCCAAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31439	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				CCCTTTGTGGTGCCAAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31440	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				AATGACCTGGAACACTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31441	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				AATGACCTGGAACACTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31442	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				TTCTAAGCCAGTTAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31443	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				TTCTAAGCCAGTTAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31444	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				CCATTTCTGGTGACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31445	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				CCATTTCTGGTGACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	indirect	Non Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31446	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				GAAAAACGTACTGCTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31447	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				GAAAAACGTACTGCTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31448	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				AAGTATACACTGAAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31449	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				AAGTATACACTGAAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31450	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				GCTTGTGCTTCTGTCTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31451	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				GCTTGTGCTTCTGTCTCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31452	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				AAATTGATTGATTCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31453	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				AAATTGATTGATTCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31454	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				GGACTCACCCCCATCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31455	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				GGACTCACCCCCATCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31456	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				ACTCTGTGTTTGGCTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31457	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				ACTCTGTGTTTGGCTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15495	chr1	216018126	216019737	215844784	215846395	31458	hg19	N/A	N/A	N/A	Enhatls17029	enhancer	E_109				GATTTTTAGAGAGTCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15494
enhrx-15496	chr1	216018126	216019737	215844784	215846395	31459	hg19	N/A	N/A	N/A	Enhatls17030	enhancer	E_109				GATTTTTAGAGAGTCGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					USH2A	chr1	215622890	216423448	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15495
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31460	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				AGGAGATTCTCTACACTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31461	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				ACTCACTTATACCCTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31462	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				ATTCTTTCATCAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31463	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				GACCCAAAGTATCTTTGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31464	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				TATAGCAAGTCAGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31465	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				TGACTGATTTCTGAACATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31466	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				CATGACGGATATTCTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31467	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				CCTTGTATAGATACATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31468	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				GAAGTCACGGATTTAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31469	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				TTTAGCATTTGAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-15556	chr1	217448224	217450357	217274882	217277015	31470	hg19	N/A	enh27501	N/A	Enhatls17091	enhancer	E_110				GGCTTTCCTTTTCAGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ESRRG	direct	Highly Significant	NA					ESRRG	chr1	216503245	217137755	132742				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	15555
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31471	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GTCCATAGCTCAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31472	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				GTCCATAGCTCAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31473	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GTCCATAGCTCAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31474	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TACAGGACCCTGCCCTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31475	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				TACAGGACCCTGCCCTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31476	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TACAGGACCCTGCCCTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31477	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TCTCATGCTATATTTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31478	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				TCTCATGCTATATTTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31479	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TCTCATGCTATATTTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31480	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				AGAGGAACTGACTCTGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31481	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				AGAGGAACTGACTCTGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31482	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				AGAGGAACTGACTCTGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31483	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				AAGGAGACTTCAGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31484	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				AAGGAGACTTCAGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31485	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				AAGGAGACTTCAGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31486	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				CTGGGGATGTATCCCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31487	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				CTGGGGATGTATCCCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31488	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				CTGGGGATGTATCCCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31489	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				CCACTTCAGCTGCGATAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31490	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				CCACTTCAGCTGCGATAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31491	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				CCACTTCAGCTGCGATAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31492	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TTTAAGCAGCACAGAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31493	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				TTTAAGCAGCACAGAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31494	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TTTAAGCAGCACAGAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31495	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GCTTAATCTCCTTACTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31496	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				GCTTAATCTCCTTACTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31497	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GCTTAATCTCCTTACTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31498	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GACTCAGTGTCTCCCGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31499	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				GACTCAGTGTCTCCCGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31500	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GACTCAGTGTCTCCCGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31501	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GACAGCATCCAGGGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31502	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				GACAGCATCCAGGGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31503	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				GACAGCATCCAGGGACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31504	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TGTGTGGTACGATGTGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	31767				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31505	hg19	N/A	enh12749	fant5125	Enhatls17929	enhancer	E_111				TGTGTGGTACGATGTGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	34602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	228916574	228917642	228780827	228781895	31506	hg19	N/A	enh12749	N/A	Enhatls17929	enhancer	E_111				TGTGTGGTACGATGTGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	35025				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31507	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGTCTAAGAAGGGAGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31508	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATGTCTAAGAAGGGAGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31509	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGTCTAAGAAGGGAGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31510	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATGTCTAAGAAGGGAGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31511	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATGTCTAAGAAGGGAGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31512	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TGACCTGTGCCGCCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31513	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				TGACCTGTGCCGCCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31514	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TGACCTGTGCCGCCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31515	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				TGACCTGTGCCGCCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31516	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				TGACCTGTGCCGCCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31517	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TCTCTGCCTTAAACCCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31518	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				TCTCTGCCTTAAACCCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31519	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TCTCTGCCTTAAACCCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31520	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				TCTCTGCCTTAAACCCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31521	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				TCTCTGCCTTAAACCCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31522	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTGAGGCCGACTCCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31523	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				CTGAGGCCGACTCCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31524	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTGAGGCCGACTCCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31525	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				CTGAGGCCGACTCCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31526	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				CTGAGGCCGACTCCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31527	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GGTACTAAATGCCTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31528	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GGTACTAAATGCCTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31529	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GGTACTAAATGCCTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31530	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GGTACTAAATGCCTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31531	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GGTACTAAATGCCTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31532	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TTTGTCCTAACACACTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31533	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				TTTGTCCTAACACACTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31534	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TTTGTCCTAACACACTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31535	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				TTTGTCCTAACACACTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31536	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				TTTGTCCTAACACACTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31537	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GTCTCTTTCTTTGCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31538	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GTCTCTTTCTTTGCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31539	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GTCTCTTTCTTTGCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31540	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GTCTCTTTCTTTGCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31541	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GTCTCTTTCTTTGCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31542	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGCCACCGTCACTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31543	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATGCCACCGTCACTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31544	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGCCACCGTCACTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31545	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATGCCACCGTCACTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31546	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATGCCACCGTCACTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31547	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AGTGAGCCATGGGAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31548	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				AGTGAGCCATGGGAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31549	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AGTGAGCCATGGGAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31550	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				AGTGAGCCATGGGAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31551	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				AGTGAGCCATGGGAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31552	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GTTGTCTTCTAGCTGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31553	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GTTGTCTTCTAGCTGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31554	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GTTGTCTTCTAGCTGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31555	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GTTGTCTTCTAGCTGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31556	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GTTGTCTTCTAGCTGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31557	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTACCTGCTCTGAAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31558	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				CTACCTGCTCTGAAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31559	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTACCTGCTCTGAAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31560	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				CTACCTGCTCTGAAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31561	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				CTACCTGCTCTGAAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31562	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGAGAACATCCGCTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31563	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATGAGAACATCCGCTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31564	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATGAGAACATCCGCTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31565	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATGAGAACATCCGCTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31566	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATGAGAACATCCGCTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31567	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATAAATAACTGTTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31568	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATAAATAACTGTTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31569	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATAAATAACTGTTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31570	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATAAATAACTGTTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31571	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATAAATAACTGTTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31572	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AGAATGACAACAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31573	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				AGAATGACAACAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31574	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AGAATGACAACAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31575	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				AGAATGACAACAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31576	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				AGAATGACAACAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31577	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AAAAATAATGGGCTTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31578	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				AAAAATAATGGGCTTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31579	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AAAAATAATGGGCTTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31580	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				AAAAATAATGGGCTTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31581	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				AAAAATAATGGGCTTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31582	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTATGATCTTGGTAATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31583	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				CTATGATCTTGGTAATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31584	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTATGATCTTGGTAATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31585	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				CTATGATCTTGGTAATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31586	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				CTATGATCTTGGTAATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31587	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATAAGTCTCACAAATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31588	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATAAGTCTCACAAATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31589	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATAAGTCTCACAAATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31590	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATAAGTCTCACAAATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31591	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATAAGTCTCACAAATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31592	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GGAGACTTGAGGGCTAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31593	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GGAGACTTGAGGGCTAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31594	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GGAGACTTGAGGGCTAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31595	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GGAGACTTGAGGGCTAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31596	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GGAGACTTGAGGGCTAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31597	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TTCACATTGGCCTATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31598	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				TTCACATTGGCCTATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31599	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TTCACATTGGCCTATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31600	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				TTCACATTGGCCTATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31601	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				TTCACATTGGCCTATTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31602	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATCCTTTGTGTGCTTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31603	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				ATCCTTTGTGTGCTTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31604	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				ATCCTTTGTGTGCTTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31605	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				ATCCTTTGTGTGCTTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31606	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				ATCCTTTGTGTGCTTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31607	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GACTAAGCAGGGTCAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31608	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GACTAAGCAGGGTCAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31609	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GACTAAGCAGGGTCAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31610	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GACTAAGCAGGGTCAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31611	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GACTAAGCAGGGTCAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31612	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CGCACGGTCTGGCTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31613	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				CGCACGGTCTGGCTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31614	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CGCACGGTCTGGCTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31615	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				CGCACGGTCTGGCTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31616	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				CGCACGGTCTGGCTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31617	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TATGAACAGCATGAGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31618	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				TATGAACAGCATGAGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31619	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				TATGAACAGCATGAGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31620	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				TATGAACAGCATGAGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31621	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				TATGAACAGCATGAGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31622	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTGTTCATTATCACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31623	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				CTGTTCATTATCACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31624	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				CTGTTCATTATCACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31625	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				CTGTTCATTATCACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31626	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				CTGTTCATTATCACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31627	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GACCTTCTCCCAACCCATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31628	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				GACCTTCTCCCAACCCATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31629	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				GACCTTCTCCCAACCCATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31630	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				GACCTTCTCCCAACCCATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31631	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				GACCTTCTCCCAACCCATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31632	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AATGGCCCTGGGTAAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	181995				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31633	hg19	N/A	enh47305	fant5136	Enhatls17929	enhancer	E_113				AATGGCCCTGGGTAAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	191881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31634	hg19	N/A	enh47305	N/A	Enhatls17929	enhancer	E_113				AATGGCCCTGGGTAAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	192147				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31635	hg19	N/A	N/A	N/A	Enhatls17929	enhancer	E_113				AATGGCCCTGGGTAAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	194225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229070940	229085979	228935193	228950232	31636	hg19	N/A	enh98618	N/A	Enhatls17929	enhancer	E_113				AATGGCCCTGGGTAAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RHOU	chr1	228735478	228746664	200935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31637	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AAGAGCTTAGGTAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31638	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				AAGAGCTTAGGTAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31639	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AAGAGCTTAGGTAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31640	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				AAGAGCTTAGGTAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31641	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AAGAGCTTAGGTAAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31642	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TACGTCACAAGAAGCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31643	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				TACGTCACAAGAAGCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31644	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TACGTCACAAGAAGCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31645	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				TACGTCACAAGAAGCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31646	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TACGTCACAAGAAGCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31647	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TGTGATCCATAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31648	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				TGTGATCCATAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31649	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TGTGATCCATAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31650	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				TGTGATCCATAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31651	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				TGTGATCCATAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31652	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GTTCTCTCAAAAACTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31653	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				GTTCTCTCAAAAACTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31654	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GTTCTCTCAAAAACTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31655	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				GTTCTCTCAAAAACTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31656	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GTTCTCTCAAAAACTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31657	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGCCACACTGCCTGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31658	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				AGCCACACTGCCTGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31659	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGCCACACTGCCTGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31660	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				AGCCACACTGCCTGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31661	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGCCACACTGCCTGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31662	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GGGTGGGGAGCATTCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31663	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				GGGTGGGGAGCATTCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31664	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GGGTGGGGAGCATTCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31665	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				GGGTGGGGAGCATTCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31666	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GGGTGGGGAGCATTCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31667	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				CTAATGATTCTGTGAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31668	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				CTAATGATTCTGTGAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31669	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				CTAATGATTCTGTGAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31670	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				CTAATGATTCTGTGAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31671	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				CTAATGATTCTGTGAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31672	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGTCCCACACTGCCCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31673	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				AGTCCCACACTGCCCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31674	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGTCCCACACTGCCCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31675	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				AGTCCCACACTGCCCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31676	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				AGTCCCACACTGCCCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31677	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GCACAAGCTTGGCCCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31678	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				GCACAAGCTTGGCCCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31679	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GCACAAGCTTGGCCCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31680	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				GCACAAGCTTGGCCCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31681	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				GCACAAGCTTGGCCCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31682	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				ACCACTGCCAGTCCACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	41238				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31683	hg19	N/A	enh12764	fant5159	Enhatls17929	enhancer	E_114				ACCACTGCCAGTCCACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31684	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				ACCACTGCCAGTCCACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40407				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31685	hg19	N/A	enh12764	fant5160	Enhatls17929	enhancer	E_114				ACCACTGCCAGTCCACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	40011				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-16336	chr1	229365025	229368892	229229278	229233145	31686	hg19	N/A	enh12764	N/A	Enhatls17929	enhancer	E_114				ACCACTGCCAGTCCACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF5L	direct	Highly Significant	NA					RAB4A	chr1	229271061	229305894	37114				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	16335
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31687	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31688	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31689	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31690	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31691	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31692	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				CATTGCAGTTAGAGGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31693	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31694	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31695	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31696	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31697	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31698	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31699	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31700	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31701	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31702	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31703	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31704	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				GCTGTCAGAGTGGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31705	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31706	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31707	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31708	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31709	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31710	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				TGTGAAGAGCATACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31711	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31712	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31713	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31714	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31715	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31716	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				ATATCTTACATAGCGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31717	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31718	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31719	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31720	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31721	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31722	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				TATTGGTTAATGCAGATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31723	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31724	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31725	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31726	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31727	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31728	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				AATGAGGCTGGGTTCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31729	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31730	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31731	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31732	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31733	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31734	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				GGCTCGCTGCAACCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31735	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31736	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31737	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31738	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31739	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31740	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				TAGAAAGAGCTGTACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31741	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31742	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31743	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31744	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31745	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31746	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				AGGCTTCCCTAGGTTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31747	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31748	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31749	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31750	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31751	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31752	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				AGGGGGACGAAAGGAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31753	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31754	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31755	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31756	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31757	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31758	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				GTAAAGGAGTCAGGCATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31759	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31760	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31761	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31762	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31763	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31764	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				AGTGAAATCAACTGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31765	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31766	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31767	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31768	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31769	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31770	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				GCTGAGGGATGTGCCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31771	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31772	hg19	N/A	enh61992	fant5499	Enhatls18858	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31773	hg19	N/A	enh61992	N/A	Enhatls18858	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17239	chr1	243426258	243435586	243262956	243272284	31774	hg19	N/A	N/A	N/A	Enhatls18858	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17238
enhrx-17240	chr1	243426258	243435586	243262956	243272284	31775	hg19	N/A	N/A	N/A	Enhatls18859	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17239
enhrx-17241	chr1	243426258	243435586	243262956	243272284	31776	hg19	N/A	N/A	N/A	Enhatls18860	enhancer	E_115				TCATTATTTCTCGTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17240
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31777	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31778	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31779	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31780	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31781	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31782	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				ATGATTTTAATGTCAATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31783	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31784	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31785	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31786	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31787	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31788	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TTGCTAAGTGACCACGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31789	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31790	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31791	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31792	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31793	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31794	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TGCCAAAGAAGTGGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31795	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31796	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31797	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31798	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31799	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31800	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TTTTCTTTGCTCATGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31801	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31802	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31803	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31804	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31805	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31806	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TCAGAATCATAGAAAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31807	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31808	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31809	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31810	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31811	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31812	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				ATGTGAGCTAAATATAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31813	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31814	hg19	N/A	N/A	fant5500	Enhatls18861	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17242	chr1	243447346	243452911	243284044	243289609	31815	hg19	N/A	N/A	N/A	Enhatls18861	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17241
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31816	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31817	hg19	N/A	N/A	fant5501	Enhatls18862	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17243	chr1	243447346	243452911	243284044	243289609	31818	hg19	N/A	N/A	N/A	Enhatls18862	enhancer	E_116				TCACTTACACAGGTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					SDCCAG8	chr1	243256040	243500091	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17242
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31819	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				GTTGTAGAAGTCCAACAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31820	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				CTTAGGGATAATTCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31821	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				CATATGTGATACTCAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31822	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				AAACATTTGCAAGCTGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31823	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				TTTGGGAGTTGTAGGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31824	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				ACAATTTGGAATGTTTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31825	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				AATTGGGGTGTGACTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31826	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				TGTATCAGTGAAGGTAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31827	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				TTTTGTTTCTGGCTCATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	direct	Highly Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31828	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				TGGAAGAGCCTCTAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31829	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				TGTTCATGACCCAAGCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31830	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				GTAGGTGTATTACGCGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17265	chr1	243882056	243883558	243718754	243720256	31831	hg19	N/A	enh27687	N/A	Enhatls18886	enhancer	E_117				ATGTCTCTCTCTTAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17264
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31832	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				AGCATTGGCAGAGCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31833	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				GCTGGTAACCGGCTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31834	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				CCATACCAGCAGCTTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31835	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				TCTTACTCAGGCTTAGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31836	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				CACCACCGTCACCAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31837	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				GTGAACTAGTGTCTTCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17267	chr1	244087611	244088521	243924309	243925219	31838	hg19	N/A	enh12841	N/A	Enhatls18888	enhancer	E_118				ATTTCCAGTAGTATCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT3	indirect	Non Significant	NA					AKT3	chr1	243488232	243851079	70645				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	17266
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31839	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				CGGGTTACACCTTCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31840	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				CGGGTTACACCTTCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31841	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				CGGGTTACACCTTCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31842	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TCTCACCTCTCCAGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31843	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				TCTCACCTCTCCAGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31844	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TCTCACCTCTCCAGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31845	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TTCCATGGCAGCTTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31846	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				TTCCATGGCAGCTTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31847	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TTCCATGGCAGCTTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31848	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TCCGGCCCACCTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31849	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				TCCGGCCCACCTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31850	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				TCCGGCCCACCTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31851	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				GCAGGAATCATGTTCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31852	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				GCAGGAATCATGTTCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31853	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				GCAGGAATCATGTTCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31854	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				CTGATTCCACATCTCATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31855	hg19	N/A	enh27727	fant34372	Enhatls19320	enhancer	E_120				CTGATTCCACATCTCATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	80332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3027919	3028458	2985727	2986266	31856	hg19	N/A	enh27727	N/A	Enhatls19320	enhancer	E_120				CTGATTCCACATCTCATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	78290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31857	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ATCTAATTTGACCCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31858	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				ATCTAATTTGACCCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31859	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ATCTAATTTGACCCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31860	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GTTGTTACTCTTACTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31861	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				GTTGTTACTCTTACTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31862	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GTTGTTACTCTTACTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31863	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CAGCTCACTGACTAACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31864	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				CAGCTCACTGACTAACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31865	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CAGCTCACTGACTAACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31866	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GGGCAGATTCCAATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31867	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				GGGCAGATTCCAATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31868	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GGGCAGATTCCAATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31869	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CAGACGCTGGAGGGGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31870	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				CAGACGCTGGAGGGGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31871	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CAGACGCTGGAGGGGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31872	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ATGACTAAGCAGCTGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31873	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				ATGACTAAGCAGCTGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31874	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ATGACTAAGCAGCTGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31875	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				TCACCACAGGACAAGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31876	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				TCACCACAGGACAAGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31877	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				TCACCACAGGACAAGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31878	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ACCTCAAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31879	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				ACCTCAAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31880	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				ACCTCAAGGTCTGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31881	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CATCTGTCCTGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31882	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				CATCTGTCCTGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31883	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				CATCTGTCCTGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31884	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GAGAGTGTGTGTCCTAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31885	hg19	hs1958	enh12899	fant34374	Enhatls19320	enhancer	E_121				GAGAGTGTGTGTCCTAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	20143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17683	chr10	3087716	3088763	3045524	3046571	31886	hg19	hs1958	enh12899	N/A	Enhatls19320	enhancer	E_121				GAGAGTGTGTGTCCTAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	18084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	118
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31887	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTTTTTAAAGTTACAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31888	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TTTTTTAAAGTTACAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31889	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTTTTTAAAGTTACAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31890	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TTTTTTAAAGTTACAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31891	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				CGTCCGAGAAAGCCACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31892	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				CGTCCGAGAAAGCCACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31893	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				CGTCCGAGAAAGCCACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31894	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				CGTCCGAGAAAGCCACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31895	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				ATCGCCGAATCCATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31896	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				ATCGCCGAATCCATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31897	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				ATCGCCGAATCCATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31898	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				ATCGCCGAATCCATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31899	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				ATATAGAATGATCTCCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31900	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				ATATAGAATGATCTCCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31901	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				ATATAGAATGATCTCCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31902	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				ATATAGAATGATCTCCTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31903	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				CACATCTAAGAACATGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31904	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				CACATCTAAGAACATGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31905	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				CACATCTAAGAACATGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31906	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				CACATCTAAGAACATGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31907	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TGGATCCGATACAGCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31908	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TGGATCCGATACAGCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31909	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TGGATCCGATACAGCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31910	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TGGATCCGATACAGCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31911	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GCCAGTTTTATGACTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31912	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				GCCAGTTTTATGACTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31913	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GCCAGTTTTATGACTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31914	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				GCCAGTTTTATGACTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31915	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TCTTTTGAAGTCTTCTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31916	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TCTTTTGAAGTCTTCTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31917	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TCTTTTGAAGTCTTCTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31918	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TCTTTTGAAGTCTTCTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31919	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTTCTACGTTGTAGTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31920	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TTTCTACGTTGTAGTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31921	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTTCTACGTTGTAGTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31922	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TTTCTACGTTGTAGTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31923	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TGAAAGACGGCTTAGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31924	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TGAAAGACGGCTTAGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31925	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TGAAAGACGGCTTAGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31926	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TGAAAGACGGCTTAGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31927	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GCTCACGCATGCACTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31928	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				GCTCACGCATGCACTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31929	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GCTCACGCATGCACTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31930	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				GCTCACGCATGCACTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31931	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTGTGTTGCATAGATGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31932	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				TTGTGTTGCATAGATGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31933	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				TTGTGTTGCATAGATGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31934	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				TTGTGTTGCATAGATGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31935	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GAGTTCACAGAATTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31936	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				GAGTTCACAGAATTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31937	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				GAGTTCACAGAATTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31938	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				GAGTTCACAGAATTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31939	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				AGTCAACCATGCACCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31940	hg19	N/A	enh12900	fant34377	Enhatls19323	enhancer	E_122				AGTCAACCATGCACCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31941	hg19	N/A	enh12900	N/A	Enhatls19323	enhancer	E_122				AGTCAACCATGCACCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17686	chr10	3131938	3141173	3089746	3098981	31942	hg19	N/A	N/A	N/A	Enhatls19323	enhancer	E_122				AGTCAACCATGCACCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31943	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				ATCCTGAGCTCCAAGGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31944	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				TGAGTGGCGCCGTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31945	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				TCTCCCTTCAGGGTCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31946	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				GAACAGTGTGAATCCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31947	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				TGGATGGCTCCGGGTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31948	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				GTGACTGGTGACTCATGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31949	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				AAATTTGGTGATTCTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31950	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				GATGTTTGCAACGTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31951	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				GCTGGAGACAAGGGACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31952	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				TGCTTCGGAAGCCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17700	chr10	3164057	3167216	3121865	3125024	31953	hg19	N/A	enh64241	N/A	Enhatls19337	enhancer	E_123				AGCACCGCATAGATTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PFKP	chr10	3066332	3137718	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	135
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31954	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				GTGGCTCTTAATCCAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31955	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				AGTTACAGTAGCCTTCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31956	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				ATCTTTGTGGAAAATTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31957	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				TCACTGGCCCAGACTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31958	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				AAAAGAGCTTGGTATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31959	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				CAGCTCCGAAGATTTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31960	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				CAGCAGCCAAAAACTGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31961	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				TCAGTCCTCAGAGATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31962	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				ACGTTGTGCAGGGAAGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31963	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				TGCATAGCTTCTGAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31964	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				AAGCTGCCCGGAGAGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3365719	3366589	3323527	3324397	31965	hg19	N/A	enh12903	N/A	Enhatls19357	enhancer	E_124				AGGTGGGACATCCTGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	146073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31966	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				ATGCATCTGTGACATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31967	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				GCAGTGACCTTCCCGAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31968	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				AAAGAGCAAAAGGGCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31969	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				CAGACCCTCGGGATGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31970	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				GATGTGCTCACCAGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31971	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				CAGGGTCTTGCCATAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31972	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				ACGAGACACCCTAAACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3381085	3382505	3338893	3340313	31973	hg19	N/A	enh12904	N/A	Enhatls19357	enhancer	E_125				AATCCAGACTATCTGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	159138				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31974	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GGGAGGCTGACGATCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31975	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				GGGAGGCTGACGATCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31976	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GGGAGGCTGACGATCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31977	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				CCGAGCAGTGCAGTACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31978	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				CCGAGCAGTGCAGTACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31979	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				CCGAGCAGTGCAGTACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31980	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				AGCAGGATATGCCCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31981	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				AGCAGGATATGCCCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31982	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				AGCAGGATATGCCCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31983	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GTGGAGGTAGTTTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31984	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				GTGGAGGTAGTTTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31985	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GTGGAGGTAGTTTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31986	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				TTCAGTTGAGAATGAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31987	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				TTCAGTTGAGAATGAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31988	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				TTCAGTTGAGAATGAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31989	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GATCGCAGAGCCGGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31990	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				GATCGCAGAGCCGGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31991	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GATCGCAGAGCCGGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31992	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				ACTGTATCTGATGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31993	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				ACTGTATCTGATGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31994	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				ACTGTATCTGATGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31995	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GCCTGTGATCATCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31996	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				GCCTGTGATCATCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31997	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GCCTGTGATCATCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31998	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GCACACACACACGCTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	223500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	31999	hg19	N/A	enh12906	fant34392	Enhatls19357	enhancer	E_126				GCACACACACACGCTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3440530	3442225	3398338	3400033	32000	hg19	N/A	enh12906	N/A	Enhatls19357	enhancer	E_126				GCACACACACACGCTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	226569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32001	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				CTACTGTCCCAGAAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32002	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				CTACTGTCCCAGAAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32003	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				CTACTGTCCCAGAAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32004	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				CTACTGTCCCAGAAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32005	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				ATAGCAGGCGGAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32006	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATAGCAGGCGGAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32007	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				ATAGCAGGCGGAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32008	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATAGCAGGCGGAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32009	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				AAGACAGCTTGGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32010	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				AAGACAGCTTGGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32011	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				AAGACAGCTTGGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32012	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				AAGACAGCTTGGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32013	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				GATGGGAAGTGAGTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32014	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GATGGGAAGTGAGTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32015	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				GATGGGAAGTGAGTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32016	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GATGGGAAGTGAGTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32017	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				TTCGGGGCATTTATAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32018	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				TTCGGGGCATTTATAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32019	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				TTCGGGGCATTTATAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32020	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				TTCGGGGCATTTATAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32021	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				GGGGCGGGTGACTCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32022	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GGGGCGGGTGACTCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32023	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				GGGGCGGGTGACTCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32024	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GGGGCGGGTGACTCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32025	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				CATTACCGTCCATTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32026	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				CATTACCGTCCATTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32027	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				CATTACCGTCCATTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32028	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				CATTACCGTCCATTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32029	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				GAGAGCACTAATGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32030	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GAGAGCACTAATGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32031	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				GAGAGCACTAATGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32032	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				GAGAGCACTAATGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32033	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				ATTAGTAATTCCAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32034	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATTAGTAATTCCAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32035	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				ATTAGTAATTCCAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32036	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATTAGTAATTCCAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32037	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_127				ATTCCAAGGCTGAAACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	238403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32038	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATTCCAAGGCTGAAACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	248573				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32039	hg19	N/A	enh12907	fant34394	Enhatls19357	enhancer	E_127				ATTCCAAGGCTGAAACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3463382	3470088	3421190	3427896	32040	hg19	N/A	enh12907	N/A	Enhatls19357	enhancer	E_127				ATTCCAAGGCTGAAACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	251803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32041	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				GAAGTAAAAGCTGCTTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32042	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				TCGATGGGAGATCAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32043	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				GCCAGGAAGTCTGATTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32044	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				GACTACTGCTTTCTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32045	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				TGCAAATTCTTTTCTGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32046	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				AAGATGATTCACTTTGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3493307	3496226	3451115	3454034	32047	hg19	N/A	enh12908	N/A	Enhatls19357	enhancer	E_128				CTGTTTAATTGACAACTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					PITRM1	chr10	3137727	3172841	276633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32048	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				ATTAGACAAAAGTGACATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32049	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				TCTTGCTCCCAACTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32050	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				AATATTACTGAGACTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32051	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				CTGACGCTGCAGACAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32052	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				AATGCTCCTTTCAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32053	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				AGTCATGTGGAGCCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32054	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				GCAGTTAGTTCTCCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32055	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				TGTACAAACAGCTGTTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3558057	3559695	3515865	3517503	32056	hg19	N/A	N/A	N/A	Enhatls19357	enhancer	E_129				ATGCAGGCTGGCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	253683				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32057	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ATTGACACTGTTCGCGTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32058	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				ATTGACACTGTTCGCGTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32059	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ATTGACACTGTTCGCGTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32060	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ACTTCCACATCTAAAGCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32061	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				ACTTCCACATCTAAAGCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32062	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ACTTCCACATCTAAAGCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32063	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				GTGCATGCAGGACGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32064	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				GTGCATGCAGGACGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32065	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				GTGCATGCAGGACGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32066	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ATGGATGGTGACTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32067	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				ATGGATGGTGACTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32068	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ATGGATGGTGACTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32069	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				GGAAAGCCAGGGAAACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32070	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				GGAAAGCCAGGGAAACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32071	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				GGAAAGCCAGGGAAACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32072	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				CAAGGTGACCGGATAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32073	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				CAAGGTGACCGGATAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32074	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				CAAGGTGACCGGATAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32075	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				AACCAGGGTGCTGCGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32076	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				AACCAGGGTGCTGCGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32077	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				AACCAGGGTGCTGCGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32078	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				CTGTTGCAAGGAATGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32079	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				CTGTTGCAAGGAATGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32080	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				CTGTTGCAAGGAATGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32081	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ACTGGAACTCGAGGACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	250047				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32082	hg19	N/A	enh12912	fant34403	Enhatls19357	enhancer	E_130				ACTGGAACTCGAGGACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3567888	3568732	3525696	3526540	32083	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_130				ACTGGAACTCGAGGACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	249224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32084	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				TAGTATTATAGTATAGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32085	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				AGTCAAATCTCAACAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32086	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				GCACCATCCTGGCCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32087	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				ATCGTTCGCCGTCCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32088	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				TGTGGGTGATGAGTCAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32089	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				TGGCTCCTGTCGCCGGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32090	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				TTCTTGGGGACATTGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32091	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				ACAGTCTCCATAACTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32092	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				GAGAAGTTCTCCCAGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32093	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				CGTTTCATGCTCAAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32094	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				GACATATGTCTGTGATTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32095	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				GTTGGAAGTGCTTTCTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3574725	3575817	3532533	3533625	32096	hg19	N/A	enh12912	N/A	Enhatls19357	enhancer	E_131				GTCAGAATGACTCTTGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	240393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32097	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				GAAGAGAGGCAGGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	236885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32098	hg19	N/A	enh12913	fant34405	Enhatls19357	enhancer	E_132				GAAGAGAGGCAGGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	236577				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32099	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				GAAGAGAGGCAGGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	231303				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32100	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				TTGTGATGCCACTAAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	236885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32101	hg19	N/A	enh12913	fant34405	Enhatls19357	enhancer	E_132				TTGTGATGCCACTAAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	236577				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32102	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				TTGTGATGCCACTAAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	231303				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32103	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				TGTTAGCTGACATTCATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32104	hg19	N/A	enh12913	fant34405	Enhatls19357	enhancer	E_132				TGTTAGCTGACATTCATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236577				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32105	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				TGTTAGCTGACATTCATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	231303				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32106	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				GGAAGCGCACGGGCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32107	hg19	N/A	enh12913	fant34405	Enhatls19357	enhancer	E_132				GGAAGCGCACGGGCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236577				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32108	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				GGAAGCGCACGGGCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	231303				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32109	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				AAGTGTAGACGAAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236885				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32110	hg19	N/A	enh12913	fant34405	Enhatls19357	enhancer	E_132				AAGTGTAGACGAAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	236577				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3580638	3582399	3538446	3540207	32111	hg19	N/A	enh12913	N/A	Enhatls19357	enhancer	E_132				AAGTGTAGACGAAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	231303				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32112	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ACTAAACAGTGCTAGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32113	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				ACTAAACAGTGCTAGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32114	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ACTAAACAGTGCTAGAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32115	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCACTTGACTTAGAATATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32116	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				TCACTTGACTTAGAATATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32117	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCACTTGACTTAGAATATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32118	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ATAAAGCGAGGAGCTCTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32119	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				ATAAAGCGAGGAGCTCTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32120	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ATAAAGCGAGGAGCTCTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32121	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCAAAGTTTGTCATCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32122	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				TCAAAGTTTGTCATCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32123	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCAAAGTTTGTCATCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32124	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				CCCAGCAGAGCAGGAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32125	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				CCCAGCAGAGCAGGAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32126	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				CCCAGCAGAGCAGGAAGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32127	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TTGTAAAAAGTAATATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32128	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				TTGTAAAAAGTAATATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32129	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TTGTAAAAAGTAATATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32130	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				GCTGAATCATCCCATTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32131	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				GCTGAATCATCCCATTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32132	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				GCTGAATCATCCCATTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32133	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCAGTAGCTGTTTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32134	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				TCAGTAGCTGTTTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32135	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TCAGTAGCTGTTTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32136	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TGACTTTATCACTCACTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32137	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				TGACTTTATCACTCACTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32138	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				TGACTTTATCACTCACTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32139	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				AGAGTAATGTCTATTACATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32140	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				AGAGTAATGTCTATTACATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32141	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				AGAGTAATGTCTATTACATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32142	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				AGAGTGTGTGTTAAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32143	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				AGAGTGTGTGTTAAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32144	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				AGAGTGTGTGTTAAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32145	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ATATGAGCTGGCGGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	35461				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32146	hg19	N/A	enh12919	fant34413	Enhatls19357	enhancer	E_133				ATATGAGCTGGCGGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	34905				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17719	chr10	3781364	3785387	3739172	3743195	32147	hg19	N/A	enh12919	N/A	Enhatls19357	enhancer	E_133				ATATGAGCTGGCGGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	27619				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	154
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32148	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				TCAAGTAATCCCAAAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32149	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				ACAAGAGGTAGCCCACGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32150	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				TATGTACGAAAGTCCCTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32151	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				AAAAGGGACTCTGAGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32152	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				AGGATATGATATTTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32153	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				AAGTAGAGCAACACAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32154	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				CAACATGTCCTCCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4291693	4295718	4249501	4253526	32155	hg19	N/A	enh12933	N/A	Enhatls19369	enhancer	E_134				TCATTTACCAAAGAACATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	463628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32156	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				GGAGTTAGAATAATATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32157	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				CCTTTCCTCAAGGTGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32158	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				CTGAGAGACAGGGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32159	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				CCAGCGTCACAAGCAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32160	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				TGGAATCTGCAATCCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32161	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				ATTAACCCATCTCACTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32162	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				ATATCCATGGGCATAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4320905	4327837	4278713	4285645	32163	hg19	N/A	enh12934	N/A	Enhatls19369	enhancer	E_135				TCATTTACAGGGCCCAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					KLF6	chr10	3775995	3785281	492433				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32164	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CTGGTGGTAGTGAAGACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32165	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				CTGGTGGTAGTGAAGACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32166	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CTGGTGGTAGTGAAGACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32167	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				CTGGTGGTAGTGAAGACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32168	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CTGGTGGTAGTGAAGACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32169	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CATTGCTGAGTCATTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32170	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				CATTGCTGAGTCATTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32171	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CATTGCTGAGTCATTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32172	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				CATTGCTGAGTCATTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32173	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CATTGCTGAGTCATTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32174	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATAAACACCATAACTGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32175	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				ATAAACACCATAACTGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32176	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATAAACACCATAACTGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32177	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				ATAAACACCATAACTGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32178	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATAAACACCATAACTGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32179	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATGCTTTTGTTGGAGGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32180	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				ATGCTTTTGTTGGAGGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32181	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATGCTTTTGTTGGAGGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32182	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				ATGCTTTTGTTGGAGGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32183	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				ATGCTTTTGTTGGAGGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32184	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GAAAGTACAGTGCAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32185	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				GAAAGTACAGTGCAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32186	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GAAAGTACAGTGCAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32187	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				GAAAGTACAGTGCAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32188	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GAAAGTACAGTGCAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32189	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TATGTTTCGTCCACAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32190	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				TATGTTTCGTCCACAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32191	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TATGTTTCGTCCACAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32192	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				TATGTTTCGTCCACAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32193	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TATGTTTCGTCCACAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32194	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CGGGAGCATAAAACATTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32195	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				CGGGAGCATAAAACATTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32196	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CGGGAGCATAAAACATTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32197	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				CGGGAGCATAAAACATTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32198	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				CGGGAGCATAAAACATTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32199	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GTGAGGCACAGGCAGCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32200	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				GTGAGGCACAGGCAGCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32201	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GTGAGGCACAGGCAGCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32202	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				GTGAGGCACAGGCAGCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32203	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				GTGAGGCACAGGCAGCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32204	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TGTTAGCTGAGAAGGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32205	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				TGTTAGCTGAGAAGGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32206	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TGTTAGCTGAGAAGGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32207	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				TGTTAGCTGAGAAGGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32208	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TGTTAGCTGAGAAGGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32209	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AGATAAATGAACAAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32210	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				AGATAAATGAACAAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32211	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AGATAAATGAACAAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32212	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				AGATAAATGAACAAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32213	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AGATAAATGAACAAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32214	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TCTTGAATCAGTATTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32215	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				TCTTGAATCAGTATTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32216	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TCTTGAATCAGTATTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32217	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				TCTTGAATCAGTATTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32218	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				TCTTGAATCAGTATTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32219	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AATTCTCCCATTTTACAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32220	hg19	N/A	enh27739	fant34483	Enhatls19369	enhancer	E_136				AATTCTCCCATTTTACAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	433563				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32221	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AATTCTCCCATTTTACAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432647				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32222	hg19	N/A	enh27739	fant34484	Enhatls19369	enhancer	E_136				AATTCTCCCATTTTACAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	432491				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4394053	4397426	4351861	4355234	32223	hg19	N/A	enh27739	N/A	Enhatls19369	enhancer	E_136				AATTCTCCCATTTTACAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	428986				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32224	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				ATTTTGTACTTACTGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32225	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				ATTTTGTACTTACTGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32226	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				ATTTTGTACTTACTGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32227	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TGGCTTACTATTTAGTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32228	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				TGGCTTACTATTTAGTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32229	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TGGCTTACTATTTAGTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32230	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TAGAAAACACCCCTAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32231	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				TAGAAAACACCCCTAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32232	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TAGAAAACACCCCTAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	direct	Highly Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32233	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				GTCCAAAGATTTAACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32234	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				GTCCAAAGATTTAACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32235	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				GTCCAAAGATTTAACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32236	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TGTTGCTCTGTACGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32237	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				TGTTGCTCTGTACGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32238	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				TGTTGCTCTGTACGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32239	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				CCACCTCCTGTACATTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32240	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				CCACCTCCTGTACATTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32241	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				CCACCTCCTGTACATTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32242	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				AAGGTATTTCTTACAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413921				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32243	hg19	N/A	enh27740	fant34485	Enhatls19369	enhancer	E_137				AAGGTATTTCTTACAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	413707				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17726	chr10	4413542	4416604	4371350	4374412	32244	hg19	N/A	enh27740	N/A	Enhatls19369	enhancer	E_137				AAGGTATTTCTTACAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	411548				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	161
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32245	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32246	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32247	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32248	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32249	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32250	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32251	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32252	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32253	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TCCCCCACCTACCACATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32254	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32255	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32256	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32257	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32258	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32259	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32260	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32261	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32262	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AACAGCACCATCTAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32263	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32264	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32265	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32266	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32267	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32268	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32269	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32270	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32271	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TGTAAGGAATGCACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32272	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32273	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32274	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32275	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32276	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32277	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32278	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32279	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32280	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AAAAAAGCGTTTTAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32281	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32282	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32283	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32284	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32285	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32286	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32287	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32288	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32289	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTACACTATCCCGACTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32290	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32291	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32292	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32293	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32294	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32295	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32296	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32297	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32298	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ATGAGTCTCATATTATCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32299	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32300	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32301	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32302	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32303	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32304	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32305	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32306	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32307	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TATTTTGACTTGGACTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32308	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32309	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32310	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32311	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32312	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32313	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32314	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32315	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32316	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ACCAGGCTCTGACTCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32317	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32318	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32319	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32320	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32321	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32322	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32323	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32324	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32325	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTTGATCCTATTATAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32326	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32327	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32328	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32329	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32330	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32331	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32332	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32333	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32334	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				GTGCCACTGTAATTTTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32335	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32336	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32337	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32338	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32339	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32340	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32341	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32342	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32343	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				TCCAGCTTAGCTATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32344	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32345	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32346	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32347	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32348	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32349	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32350	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32351	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32352	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				AGGACGGTGTGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32353	hg19	N/A	enh1063	N/A	Enhatls19374	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	129031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32354	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	128901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32355	hg19	N/A	enh1063	N/A	Enhatls19375	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	127181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32356	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	126521				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32357	hg19	N/A	enh1063	N/A	Enhatls19376	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124931				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32358	hg19	N/A	enh1063	N/A	N/A	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	124211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32359	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123662				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32360	hg19	N/A	enh1063	fant34492	Enhatls19377	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	123038				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4699375	4708176	4657183	4665984	32361	hg19	N/A	enh1063	N/A	Enhatls19377	enhancer	E_138				ATGTTTAAATGCCTCTGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	120306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32362	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GAAACTTGTTTACAGAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32363	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				GAAACTTGTTTACAGAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32364	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GAAACTTGTTTACAGAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32365	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				GAAACTTGTTTACAGAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32366	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				ATATGATGCAAGTTTTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32367	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				ATATGATGCAAGTTTTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32368	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				ATATGATGCAAGTTTTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32369	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				ATATGATGCAAGTTTTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32370	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTACATTAGTCCTATTCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32371	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				CTACATTAGTCCTATTCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32372	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTACATTAGTCCTATTCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32373	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				CTACATTAGTCCTATTCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32374	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGATGGACAATGTGGATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32375	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				AGATGGACAATGTGGATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32376	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGATGGACAATGTGGATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32377	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				AGATGGACAATGTGGATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32378	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				TGGAGGATACCTGTGGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32379	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				TGGAGGATACCTGTGGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32380	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				TGGAGGATACCTGTGGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32381	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				TGGAGGATACCTGTGGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32382	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				ATACTTAATGTTTACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32383	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				ATACTTAATGTTTACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32384	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				ATACTTAATGTTTACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32385	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				ATACTTAATGTTTACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32386	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTCAGCAGCAAAGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32387	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				CTCAGCAGCAAAGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32388	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTCAGCAGCAAAGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32389	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				CTCAGCAGCAAAGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32390	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CCACAGATGAAGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32391	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				CCACAGATGAAGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32392	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CCACAGATGAAGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32393	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				CCACAGATGAAGGCAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32394	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGAGTCGTTTGTTGCTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32395	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				AGAGTCGTTTGTTGCTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32396	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGAGTCGTTTGTTGCTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32397	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				AGAGTCGTTTGTTGCTTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32398	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GCTCAAGTAAGGGGAGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32399	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				GCTCAAGTAAGGGGAGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32400	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GCTCAAGTAAGGGGAGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32401	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				GCTCAAGTAAGGGGAGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32402	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GGGGTGATGGAGAGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32403	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				GGGGTGATGGAGAGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32404	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				GGGGTGATGGAGAGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32405	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				GGGGTGATGGAGAGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32406	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTGTAACGTCTCCATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32407	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				CTGTAACGTCTCCATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32408	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				CTGTAACGTCTCCATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32409	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				CTGTAACGTCTCCATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32410	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGGTTACTATAGTCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32411	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				AGGTTACTATAGTCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32412	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				AGGTTACTATAGTCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32413	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				AGGTTACTATAGTCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32414	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				TCACGTGGATTAAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115988				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32415	hg19	N/A	enh27748	fant34493	Enhatls19377	enhancer	E_139				TCACGTGGATTAAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	115569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32416	hg19	N/A	enh27748	N/A	Enhatls19377	enhancer	E_139				TCACGTGGATTAAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	108581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-17731	chr10	4711811	4721836	4669619	4679644	32417	hg19	N/A	enh27748	N/A	N/A	enhancer	E_139				TCACGTGGATTAAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KLF6	indirect	Non Significant	NA					AKR1E2	chr10	4786628	4848062	105786				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	166
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32418	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				GTCAGGAGTGAAGACCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32419	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				GTCAGGAGTGAAGACCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32420	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				GTCAGGAGTGAAGACCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32421	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				TATTAAGGAGAGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32422	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				TATTAAGGAGAGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32423	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				TATTAAGGAGAGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32424	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CGTGGCTCCCCAATTAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32425	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				CGTGGCTCCCCAATTAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32426	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CGTGGCTCCCCAATTAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32427	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CCGTCAAGGCTGAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32428	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				CCGTCAAGGCTGAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32429	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CCGTCAAGGCTGAGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32430	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				AATGTCGGGGGAAAATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32431	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				AATGTCGGGGGAAAATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32432	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				AATGTCGGGGGAAAATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32433	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				ACTCTTTTTTTCTTCAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32434	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				ACTCTTTTTTTCTTCAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32435	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				ACTCTTTTTTTCTTCAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32436	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CTTTCTGCCACCCAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32437	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				CTTTCTGCCACCCAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32438	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CTTTCTGCCACCCAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32439	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				ACATTATCAGGCTGTATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32440	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				ACATTATCAGGCTGTATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32441	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				ACATTATCAGGCTGTATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32442	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CACTGCAGGATGAGGTTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32443	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				CACTGCAGGATGAGGTTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32444	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				CACTGCAGGATGAGGTTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32445	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				TCAACTGATACTCTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32446	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				TCAACTGATACTCTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32447	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				TCAACTGATACTCTTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32448	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				GTTTTTAAGTTTTTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32449	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				GTTTTTAAGTTTTTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32450	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				GTTTTTAAGTTTTTTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32451	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				AACTGCACTATACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32452	hg19	N/A	enh13093	fant35232	Enhatls20908	enhancer	E_141				AACTGCACTATACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19129	chr10	29870414	29881147	29581485	29592218	32453	hg19	N/A	enh13093	N/A	Enhatls20908	enhancer	E_141				AACTGCACTATACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1564
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32454	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				TTGTAGGTCTCTGTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32455	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				TTGTAGGTCTCTGTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32456	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				TTGTAGGTCTCTGTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32457	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				TTGTAGGTCTCTGTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32458	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				TTGTAGGTCTCTGTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32459	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				GTACTCCAGCCCAAGTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32460	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GTACTCCAGCCCAAGTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32461	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				GTACTCCAGCCCAAGTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32462	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GTACTCCAGCCCAAGTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32463	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				GTACTCCAGCCCAAGTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32464	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				CCCAGAGGCATACCACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32465	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				CCCAGAGGCATACCACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32466	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				CCCAGAGGCATACCACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32467	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				CCCAGAGGCATACCACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32468	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				CCCAGAGGCATACCACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32469	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				GCTGCTTCGGCCAGCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32470	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCTGCTTCGGCCAGCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32471	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				GCTGCTTCGGCCAGCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32472	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCTGCTTCGGCCAGCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32473	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				GCTGCTTCGGCCAGCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32474	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				AGGACTGTCCTCTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32475	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				AGGACTGTCCTCTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32476	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				AGGACTGTCCTCTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32477	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				AGGACTGTCCTCTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32478	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				AGGACTGTCCTCTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32479	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				TCATGACTGTTTTGTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32480	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				TCATGACTGTTTTGTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32481	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				TCATGACTGTTTTGTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32482	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				TCATGACTGTTTTGTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32483	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				TCATGACTGTTTTGTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32484	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				GTCCAAGGGAAAAGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32485	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GTCCAAGGGAAAAGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32486	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				GTCCAAGGGAAAAGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32487	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GTCCAAGGGAAAAGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32488	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				GTCCAAGGGAAAAGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32489	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				GCCCTACTTTTCTCTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32490	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCCCTACTTTTCTCTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32491	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				GCCCTACTTTTCTCTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32492	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCCCTACTTTTCTCTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32493	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				GCCCTACTTTTCTCTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32494	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				CATGAAACAGTTCACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32495	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				CATGAAACAGTTCACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32496	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				CATGAAACAGTTCACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32497	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				CATGAAACAGTTCACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32498	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				CATGAAACAGTTCACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32499	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				GCAGTGTGCAAAAACTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32500	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCAGTGTGCAAAAACTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32501	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				GCAGTGTGCAAAAACTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32502	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				GCAGTGTGCAAAAACTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32503	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				GCAGTGTGCAAAAACTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32504	hg19	N/A	enh13094	N/A	Enhatls20909	enhancer	E_142				ACTGTCCTAGATTAATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32505	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				ACTGTCCTAGATTAATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32506	hg19	N/A	N/A	fant35234	Enhatls20909	enhancer	E_142				ACTGTCCTAGATTAATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19130	chr10	29919172	29926337	29630243	29637408	32507	hg19	N/A	N/A	N/A	Enhatls20909	enhancer	E_142				ACTGTCCTAGATTAATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1565
enhrx-19131	chr10	29919172	29926337	29630243	29637408	32508	hg19	N/A	N/A	fant35235	N/A	enhancer	E_142				ACTGTCCTAGATTAATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1566
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32509	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GACGGTGTCAGAACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32510	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				TTATGGGGCCATCTAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32511	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GTGCCTTCCGGAAAATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32512	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				TCAAAAAAGGCGAAGACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32513	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				TAGAAATTAGGAAAGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32514	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GTCTTTTTCTCAACTTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32515	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GAGATAAAAGAAAGTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32516	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GGGCTCTCACCATGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32517	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				GGCATGGTGGCACACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30002755	30003278	29713826	29714349	32518	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_143				TGGTGCAGTCTCAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32519	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GACGGTGTCAGAACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32520	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GACGGTGTCAGAACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32521	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GACGGTGTCAGAACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32522	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TTATGGGGCCATCTAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32523	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				TTATGGGGCCATCTAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32524	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TTATGGGGCCATCTAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32525	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GTGCCTTCCGGAAAATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32526	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GTGCCTTCCGGAAAATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32527	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GTGCCTTCCGGAAAATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32528	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TCAAAAAAGGCGAAGACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32529	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				TCAAAAAAGGCGAAGACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32530	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TCAAAAAAGGCGAAGACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32531	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TAGAAATTAGGAAAGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32532	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				TAGAAATTAGGAAAGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32533	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TAGAAATTAGGAAAGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32534	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GTCTTTTTCTCAACTTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32535	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GTCTTTTTCTCAACTTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32536	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GTCTTTTTCTCAACTTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32537	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GAGATAAAAGAAAGTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32538	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GAGATAAAAGAAAGTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32539	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GAGATAAAAGAAAGTTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32540	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GGGCTCTCACCATGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32541	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GGGCTCTCACCATGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32542	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GGGCTCTCACCATGTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32543	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GGCATGGTGGCACACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32544	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				GGCATGGTGGCACACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32545	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				GGCATGGTGGCACACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32546	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TGGTGCAGTCTCAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32547	hg19	N/A	enh13097	fant35244	Enhatls20912	enhancer	E_144				TGGTGCAGTCTCAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19132	chr10	30003313	30003836	29714384	29714907	32548	hg19	N/A	enh13097	N/A	Enhatls20912	enhancer	E_144				TGGTGCAGTCTCAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1567
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32549	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				AGTCATGTCCTATTTCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32550	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				ATTAGGACAGGAATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32551	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				GGCATTGTCTGGTTGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32552	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				ACAGAGTTGAAACTCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32553	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				GGAGAAACAAGAGATCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32554	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				GCACAGGTGAGACTTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32555	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				AAGGTTTGTCGGGAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32556	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				ATTGGGAGTAGCACTAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32557	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				GGCTTCGTGTTTCCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	direct	Highly Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30046186	30047595	29757257	29758666	32558	hg19	N/A	enh62026	N/A	Enhatls20913	enhancer	E_145				AGTGTAATGCAAGGTAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	18678				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32559	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GGAAAGGGGCAGGAAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32560	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				GGAAAGGGGCAGGAAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32561	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GGAAAGGGGCAGGAAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32562	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				ATGTAAATACACAAGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32563	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				ATGTAAATACACAAGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32564	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				ATGTAAATACACAAGCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32565	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GACAGACCCCAGGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32566	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				GACAGACCCCAGGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32567	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GACAGACCCCAGGAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32568	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				ACTAGAAGTGATTATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32569	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				ACTAGAAGTGATTATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32570	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				ACTAGAAGTGATTATTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32571	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				AGACTCAAACCACTGGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32572	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				AGACTCAAACCACTGGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32573	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				AGACTCAAACCACTGGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32574	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TCTTTATATAATTACATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32575	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				TCTTTATATAATTACATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32576	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TCTTTATATAATTACATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32577	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GCCATCATCAGTGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32578	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				GCCATCATCAGTGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32579	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GCCATCATCAGTGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32580	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				CAAGAAGCAGAGAGCTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32581	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				CAAGAAGCAGAGAGCTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32582	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				CAAGAAGCAGAGAGCTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32583	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				CTGTTTCCAGAACTTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32584	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				CTGTTTCCAGAACTTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32585	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				CTGTTTCCAGAACTTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32586	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TATGTTGGCTCTTTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32587	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				TATGTTGGCTCTTTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32588	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TATGTTGGCTCTTTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32589	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TATTGTGGTGCAATTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32590	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				TATTGTGGTGCAATTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32591	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				TATTGTGGTGCAATTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32592	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GTAGCAGCCAGCGCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	64198				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32593	hg19	N/A	enh13099	fant35248	Enhatls20913	enhancer	E_146				GTAGCAGCCAGCGCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-19133	chr10	30091193	30096127	29802264	29807198	32594	hg19	N/A	enh13099	N/A	Enhatls20913	enhancer	E_146				GTAGCAGCCAGCGCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K8	indirect	Non Significant	NA					SVIL	chr10	29457337	29736959	67474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1568
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32595	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GAGGGGGCCCATGAGAATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32596	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GAGGGGGCCCATGAGAATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32597	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GATCCTGCCAACAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32598	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GATCCTGCCAACAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32599	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				AGGGGAGTGGAGGACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32600	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				AGGGGAGTGGAGGACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32601	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				TCCCGGGCGAGACCTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32602	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				TCCCGGGCGAGACCTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32603	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				CGCTGCTTGCGGAACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32604	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				CGCTGCTTGCGGAACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32605	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				CTGCCGGACTCCCGGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32606	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				CTGCCGGACTCCCGGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32607	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GTCCCGGGAGCAGAGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32608	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GTCCCGGGAGCAGAGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32609	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GGTCGGCGCGTGCAGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32610	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GGTCGGCGCGTGCAGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32611	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GTCCCACCCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32612	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GTCCCACCCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32613	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GGCTCTGTGTGGAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32614	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GGCTCTGTGTGGAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32615	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				CCGGATCTAGATCCAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32616	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				CCGGATCTAGATCCAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32617	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				AGACCCTACAGAAGAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32618	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				AGACCCTACAGAAGAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32619	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				GAGCTGACTCCCGTTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32620	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				GAGCTGACTCCCGTTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21850	chr10	89417163	89422781	87657406	87663024	32621	hg19	N/A	N/A	fant36425	N/A	enhancer	E_148				CTTGGAGTGGGCTTTAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	1857				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4285
enhrx-21851	chr10	89417163	89422781	87657406	87663024	32622	hg19	N/A	N/A	N/A	Enhatls24057	enhancer	E_148				CTTGGAGTGGGCTTTAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32623	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				GCATTGGCTGGGTGTATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32624	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				TATTTAAATAAAAAGAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32625	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				AGAATTTGTGTCTTCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32626	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				AGTTAGTCACATTTAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32627	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				GGAACCCTGTTGGGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32628	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				GAGTTCCCTACTGTAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32629	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				ACTTAGGGTTATGCATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32630	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				TATGACTGTGAGAATGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32631	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				ATGATGCAGGCGCTTTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32632	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				TTTTAGCAAATGCTGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32633	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				CATTTCACCTTAAGAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32634	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				CTCACATAATGGACAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32635	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				AGAACAGGCCCATAGCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32636	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				ATGTTAATATTTCGTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32637	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				ATTTTTTTCTCAATTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32638	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				AACAGGGCTAGTGTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21851	chr10	89429493	89432533	87669736	87672776	32639	hg19	N/A	enh28316	N/A	Enhatls24057	enhancer	E_149				AACTCCGCTATAATACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4286
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32640	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				GACGTGTTGCAGGCAGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32641	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				GACGTGTTGCAGGCAGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32642	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				CTTTGCATTTTGCTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32643	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				CTTTGCATTTTGCTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32644	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				TTACTGACCACATTGCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32645	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				TTACTGACCACATTGCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32646	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				TCCTCAACTAGACTATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32647	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				TCCTCAACTAGACTATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32648	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				ATAAATGACATGTATCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32649	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				ATAAATGACATGTATCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32650	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				GCAGAGAACACTAAATTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32651	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				GCAGAGAACACTAAATTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	indirect	Non Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32652	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				TGTGTACATACAGAAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32653	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				TGTGTACATACAGAAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32654	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				CGGCAGTTGCTGTCTATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32655	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				CGGCAGTTGCTGTCTATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32656	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				TTAGTTTCATAACTACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32657	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				TTAGTTTCATAACTACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32658	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				GCAGTTATTTATGGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32659	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				GCAGTTATTTATGGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32660	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				GTATAACACAAAATAATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32661	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				GTATAACACAAAATAATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21855	chr10	89480633	89486130	87720876	87726373	32662	hg19	N/A	N/A	N/A	Enhatls24061	enhancer	E_150				AGAGAATAGCCTATTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4290
enhrx-21856	chr10	89480633	89486130	87720876	87726373	32663	hg19	N/A	N/A	N/A	Enhatls24062	enhancer	E_150				AGAGAATAGCCTATTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PAPSS2	chr10	87659612	87747705	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4291
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32664	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				CATAATATATATGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32665	hg19	N/A	N/A	fant36428	Enhatls24076	enhancer	E_151				CATAATATATATGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	1787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32666	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				CATAATATATATGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	2003				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32667	hg19	N/A	enh13372	N/A	N/A	enhancer	E_151				CATAATATATATGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	3466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32668	hg19	N/A	enh13372	N/A	Enhatls24077	enhancer	E_151				CATAATATATATGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	725				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32669	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				GTGAGTACTCTACCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32670	hg19	N/A	N/A	fant36428	Enhatls24076	enhancer	E_151				GTGAGTACTCTACCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	1787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32671	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				GTGAGTACTCTACCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	2003				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32672	hg19	N/A	enh13372	N/A	N/A	enhancer	E_151				GTGAGTACTCTACCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	3466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32673	hg19	N/A	enh13372	N/A	Enhatls24077	enhancer	E_151				GTGAGTACTCTACCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	725				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32674	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				CATGTCTAGTGAGCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32675	hg19	N/A	N/A	fant36428	Enhatls24076	enhancer	E_151				CATGTCTAGTGAGCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	1787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32676	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				CATGTCTAGTGAGCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	2003				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32677	hg19	N/A	enh13372	N/A	N/A	enhancer	E_151				CATGTCTAGTGAGCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	3466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32678	hg19	N/A	enh13372	N/A	Enhatls24077	enhancer	E_151				CATGTCTAGTGAGCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	725				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32679	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				AGGGAGAAAACTCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32680	hg19	N/A	N/A	fant36428	Enhatls24076	enhancer	E_151				AGGGAGAAAACTCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	1787				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21870	chr10	89600558	89609474	87840801	87849717	32681	hg19	N/A	N/A	N/A	Enhatls24076	enhancer	E_151				AGGGAGAAAACTCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	2003				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4305
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32682	hg19	N/A	enh13372	N/A	N/A	enhancer	E_151				AGGGAGAAAACTCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					ATAD1	chr10	87751511	87841343	3466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21871	chr10	89600558	89609474	87840801	87849717	32683	hg19	N/A	enh13372	N/A	Enhatls24077	enhancer	E_151				AGGGAGAAAACTCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	725				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32684	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				AAACGTGCACGGTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32685	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				AAACGTGCACGGTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32686	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				AAACGTGCACGGTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32687	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				CGGGTTTTCACGGCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32688	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				CGGGTTTTCACGGCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32689	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				CGGGTTTTCACGGCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32690	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				CACCGGAGCGGGCGCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32691	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				CACCGGAGCGGGCGCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32692	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				CACCGGAGCGGGCGCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32693	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				TTTGGGCCCTTGAAATTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32694	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				TTTGGGCCCTTGAAATTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32695	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				TTTGGGCCCTTGAAATTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32696	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				CGAGTTACCGGGGAAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32697	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				CGAGTTACCGGGGAAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32698	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				CGAGTTACCGGGGAAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32699	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				CACGCTGGCGACACAATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32700	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				CACGCTGGCGACACAATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32701	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				CACGCTGGCGACACAATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32702	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				AAGGGGGAATCTCTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32703	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				AAGGGGGAATCTCTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32704	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				AAGGGGGAATCTCTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32705	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				AGCGAATGCAGTCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32706	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				AGCGAATGCAGTCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32707	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				AGCGAATGCAGTCCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32708	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GGTCCTTTTCACCTGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32709	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GGTCCTTTTCACCTGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32710	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GGTCCTTTTCACCTGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32711	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GGTAGGCTGTTGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32712	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GGTAGGCTGTTGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32713	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GGTAGGCTGTTGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32714	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GAGGATAACGAGCTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32715	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GAGGATAACGAGCTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32716	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GAGGATAACGAGCTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32717	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GCGCAGAGTCCCCAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32718	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GCGCAGAGTCCCCAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32719	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GCGCAGAGTCCCCAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32720	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GGCGGGAGGCGAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32721	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GGCGGGAGGCGAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32722	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GGCGGGAGGCGAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32723	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GCGGGACTCTTTATGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32724	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GCGGGACTCTTTATGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32725	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GCGGGACTCTTTATGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32726	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				TGCGCTCAGTTCTCTCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32727	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				TGCGCTCAGTTCTCTCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32728	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				TGCGCTCAGTTCTCTCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32729	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GCGAGGCCGGGCTCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32730	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GCGAGGCCGGGCTCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32731	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GCGAGGCCGGGCTCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32732	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				GCGCCTGTGAGCAGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32733	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				GCGCCTGTGAGCAGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32734	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				GCGCCTGTGAGCAGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32735	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				TTCAGGAGAAGCCGAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32736	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				TTCAGGAGAAGCCGAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32737	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				TTCAGGAGAAGCCGAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21871	chr10	89620280	89628911	87860523	87869154	32738	hg19	N/A	enh13372	N/A	N/A	enhancer	E_152				CTCCCGCTCCTGGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					KLLN	chr10	87859157	87863533	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32739	hg19	N/A	enh1401	N/A	N/A	enhancer	E_152				CTCCCGCTCCTGGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21872	chr10	89620280	89628911	87860523	87869154	32740	hg19	N/A	enh1401	N/A	Enhatls24078	enhancer	E_152				CTCCCGCTCCTGGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32741	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				CTTAAGACGAGTGGGAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32742	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				AGGAGCCTTGTCAACCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32743	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				GGAAGAACTAATATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32744	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				ATATTTGCCAACAGTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32745	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				CACAAATTCCGGGAAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32746	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				GAAACTTTTAAATGGGATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32747	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				GTAGCAGCCTCTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32748	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				GGGAACCACTCACATCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32749	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				GCTGAAGATGTAGCTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89762810	89766421	88003053	88006664	32750	hg19	N/A	enh13373	N/A	Enhatls24087	enhancer	E_153				ACCTCAGCACCCCGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	30339				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32751	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				GAAAGAAATTTGGAATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32752	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				GAAAGAAATTTGGAATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32753	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				GAAAGAAATTTGGAATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32754	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				GAAAGAAATTTGGAATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32755	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				GAAAGAAATTTGGAATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32756	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGCTCACAGTGTATTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32757	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				ATGCTCACAGTGTATTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32758	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGCTCACAGTGTATTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32759	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				ATGCTCACAGTGTATTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32760	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGCTCACAGTGTATTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32761	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTACAAGACAGTAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32762	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				TTACAAGACAGTAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32763	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTACAAGACAGTAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32764	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				TTACAAGACAGTAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32765	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTACAAGACAGTAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32766	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CAGGGAAGAGGCTCAATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32767	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				CAGGGAAGAGGCTCAATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32768	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CAGGGAAGAGGCTCAATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32769	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				CAGGGAAGAGGCTCAATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32770	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CAGGGAAGAGGCTCAATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32771	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTTAGAGTAGACTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32772	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				TTTAGAGTAGACTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32773	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTTAGAGTAGACTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32774	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				TTTAGAGTAGACTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32775	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				TTTAGAGTAGACTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32776	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGGCCAGTGAAAAATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32777	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				ATGGCCAGTGAAAAATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32778	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGGCCAGTGAAAAATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32779	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				ATGGCCAGTGAAAAATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32780	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ATGGCCAGTGAAAAATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32781	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AAGAAAAATTGGAATTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32782	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				AAGAAAAATTGGAATTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32783	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AAGAAAAATTGGAATTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32784	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				AAGAAAAATTGGAATTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32785	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AAGAAAAATTGGAATTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32786	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AATGGACCCAGAGCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32787	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				AATGGACCCAGAGCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32788	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AATGGACCCAGAGCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32789	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				AATGGACCCAGAGCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32790	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AATGGACCCAGAGCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32791	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGGTACGCAGCAGATTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32792	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				AGGTACGCAGCAGATTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32793	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGGTACGCAGCAGATTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32794	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				AGGTACGCAGCAGATTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32795	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGGTACGCAGCAGATTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32796	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CTTTATTTGGATGACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32797	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				CTTTATTTGGATGACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32798	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CTTTATTTGGATGACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32799	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				CTTTATTTGGATGACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32800	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				CTTTATTTGGATGACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32801	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ACTTACTGTCTATTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32802	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				ACTTACTGTCTATTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32803	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ACTTACTGTCTATTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32804	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				ACTTACTGTCTATTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32805	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				ACTTACTGTCTATTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32806	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGAGTCACTTTGCCTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	138654				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32807	hg19	N/A	enh1406	fant36446	Enhatls24087	enhancer	E_154				AGAGTCACTTTGCCTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144158				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32808	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGAGTCACTTTGCCTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32809	hg19	N/A	enh1406	fant36447	Enhatls24087	enhancer	E_154				AGAGTCACTTTGCCTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144637				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89873740	89879016	88113983	88119259	32810	hg19	N/A	enh1406	N/A	Enhatls24087	enhancer	E_154				AGAGTCACTTTGCCTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					PTEN	chr10	87862637	87971930	144836				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32811	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CTGTCACATGATACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32812	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				CTGTCACATGATACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32813	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CTGTCACATGATACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32814	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				CTGTCACATGATACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32815	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CTGTCACATGATACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32816	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TTAGCATGCTCACTTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32817	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				TTAGCATGCTCACTTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32818	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TTAGCATGCTCACTTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32819	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				TTAGCATGCTCACTTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32820	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TTAGCATGCTCACTTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32821	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				ATTTCCTAGAGACACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32822	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				ATTTCCTAGAGACACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32823	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				ATTTCCTAGAGACACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32824	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				ATTTCCTAGAGACACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32825	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				ATTTCCTAGAGACACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32826	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TGTAGCCTATGAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32827	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				TGTAGCCTATGAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32828	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TGTAGCCTATGAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32829	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				TGTAGCCTATGAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32830	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				TGTAGCCTATGAAATAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32831	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCTTGTTGGATAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32832	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				GATCTTGTTGGATAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32833	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCTTGTTGGATAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32834	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				GATCTTGTTGGATAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32835	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCTTGTTGGATAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32836	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GAGTCAGAGAATCCCGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32837	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				GAGTCAGAGAATCCCGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32838	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GAGTCAGAGAATCCCGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32839	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				GAGTCAGAGAATCCCGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32840	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GAGTCAGAGAATCCCGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32841	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CACATACCTTCCAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32842	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				CACATACCTTCCAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32843	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CACATACCTTCCAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32844	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				CACATACCTTCCAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32845	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CACATACCTTCCAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32846	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CCAAGAGGAATTTCTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32847	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				CCAAGAGGAATTTCTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32848	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CCAAGAGGAATTTCTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32849	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				CCAAGAGGAATTTCTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32850	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				CCAAGAGGAATTTCTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32851	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCCCAGTAATTTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32852	hg19	N/A	enh28319	fant36449	Enhatls24087	enhancer	E_155				GATCCCAGTAATTTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	120582				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32853	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCCCAGTAATTTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32854	hg19	N/A	enh28319	fant36450	Enhatls24087	enhancer	E_155				GATCCCAGTAATTTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	117301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89909256	89919355	88149499	88159598	32855	hg19	N/A	enh28319	N/A	Enhatls24087	enhancer	E_155				GATCCCAGTAATTTATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	112466				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32856	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TTTTTTTTTGGCAGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32857	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TAAGATGCAAAATATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32858	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TCACATGTTCATCTCTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32859	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				CGAATCCATACTTTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32860	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TAGTTATTATCTATGGTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32861	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TAGTTGCAAGAGAGGTCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32862	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				GGGTAAAGGAGAGTAGATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32863	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				GTTGGGAATGCACTATAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32864	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TATCTAATAACAATATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32865	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				TGAGCCACACATCTGCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	89985752	89988730	88225995	88228973	32866	hg19	N/A	enh28321	N/A	Enhatls24087	enhancer	E_156				GACCAGTGCTGGCCTGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	32826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32867	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				TTACTGAGTAGTTCAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32868	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				AATGTGTACATAGCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32869	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				TGGCTATTCAGGCTTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32870	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				GGAAATCTAAAGCTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32871	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				GAGCATTGAGAGAAGCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32872	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				GGGGTTCCTGGGCCCAATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90002757	90004588	88243000	88244831	32873	hg19	N/A	enh13375	N/A	Enhatls24087	enhancer	E_157				TGTTCTGTCTTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	24826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32874	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				AGTTTTGTTATTAAATCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32875	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				TTAAAGGTAAGGATTTATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32876	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				ATAATATATATGCAATATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32877	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				TCACTCTCATAGTAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32878	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				GGGCTCGCTTCATTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32879	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				GTTAGTCATAGGTAGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32880	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				GCCAGGAAAAGGACTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32881	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				GCAACATGTCAGCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21879	chr10	90011499	90017250	88251742	88257493	32882	hg19	N/A	enh28322	N/A	Enhatls24087	enhancer	E_158				GTCTCACAGAAATCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					RNLS	chr10	88273863	88584530	11126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4314
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32883	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				TTGCTACAGTCATTAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32884	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				TTATGAGTCAGAGGGAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32885	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				TAGGGTATGTGATTCTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32886	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				CTTTGGAGTACCATCCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32887	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				TAGTTGTTATGCAAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32888	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				TGCTTGTATTCCAGGTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32889	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				CAAGGCTTCTAACACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32890	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				CGCATGATAAGGCAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-21903	chr10	90462343	90463806	88702586	88704049	32891	hg19	N/A	enh28326	N/A	Enhatls24111	enhancer	E_160				AATCCCAGGACACAAAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PTEN	direct	Highly Significant	NA					LIPK	chr10	88706248	88752776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4338
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32892	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32893	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32894	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32895	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32896	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32897	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32898	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				TTGCAGGGAGGTATTGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32899	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32900	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32901	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32902	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32903	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32904	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32905	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGTCCTCAGAAACAGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32906	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32907	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32908	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32909	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32910	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32911	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32912	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				ACAACTCTATGGTGACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32913	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32914	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32915	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32916	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32917	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32918	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32919	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGGGTAGGCTAATTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32920	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32921	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32922	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32923	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32924	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32925	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32926	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				AGCAGCCCAGAAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32927	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32928	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32929	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32930	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32931	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32932	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32933	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGGGCTGGAAGGGCTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32934	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32935	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32936	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32937	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32938	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32939	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32940	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				CACGGGGTGAGGGGTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32941	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32942	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32943	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32944	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32945	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32946	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32947	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGGCGATGTGAAGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32948	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32949	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32950	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32951	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32952	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32953	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32954	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				CGGCCCCTGGCTGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32955	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32956	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32957	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32958	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32959	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32960	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32961	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGCCTCTGCGTGTGTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32962	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32963	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32964	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32965	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32966	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32967	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32968	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GAGAGGGGGGCGCTCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32969	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32970	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32971	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32972	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32973	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32974	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32975	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				CTAATTGTCCTGCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32976	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32977	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32978	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32979	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32980	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32981	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32982	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GACGACGTGCGTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32983	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32984	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32985	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32986	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32987	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32988	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32989	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GAGGACGGACACCGAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32990	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32991	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32992	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32993	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32994	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32995	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	32996	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				GGCTCCGCCTCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32997	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32998	hg19	N/A	enh1477	fant36827	Enhatls25513	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	32999	hg19	N/A	enh1477	N/A	Enhatls25513	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	33000	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	33001	hg19	N/A	enh1477	fant36828	N/A	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23235	chr10	103872419	103882533	102112662	102122776	33002	hg19	N/A	enh1477	N/A	N/A	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5670
enhrx-23236	chr10	103872419	103882533	102112662	102122776	33003	hg19	N/A	N/A	N/A	Enhatls25514	enhancer	E_162				CCGCGCTCCGGGAGGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUFU	direct	Highly Significant	NA					LDB1	chr10	102106488	102120368	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5671
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33004	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				CATTTCTACTTACTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33005	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				CATTTCTACTTACTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33006	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				AGGGATAAGGCTATTGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33007	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				AGGGATAAGGCTATTGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33008	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				AGGCAATAATAAACAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33009	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				AGGCAATAATAAACAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33010	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				GCAAAGCCGTGAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33011	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				GCAAAGCCGTGAATATGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33012	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				TGAACTTTAACTGAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33013	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				TGAACTTTAACTGAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33014	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				TGTGACTGAAGTAATTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33015	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				TGTGACTGAAGTAATTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33016	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				TGAGCCCATGGATTCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33017	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				TGAGCCCATGGATTCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33018	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				GTATCAAATAACCCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33019	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				GTATCAAATAACCCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33020	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				CACTTAAGACTGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33021	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				CACTTAAGACTGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33022	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				CAACACAGGAGGACTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33023	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				CAACACAGGAGGACTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24457	chr10	123669983	123673128	121910468	121913613	33024	hg19	N/A	N/A	N/A	Enhatls26826	enhancer	E_163				GGCAGTACATTGCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6892
enhrx-24458	chr10	123669983	123673128	121910468	121913613	33025	hg19	N/A	N/A	N/A	Enhatls26827	enhancer	E_163				GGCAGTACATTGCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ATE1	chr10	121709392	121928785	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6893
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33026	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GAGGTGATGTGTGTAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33027	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				GAGGTGATGTGTGTAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33028	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GAGGTGATGTGTGTAGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33029	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				ATGGCTGTAGATGACCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33030	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				ATGGCTGTAGATGACCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33031	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				ATGGCTGTAGATGACCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33032	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TTACGAGTCTGGGTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33033	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				TTACGAGTCTGGGTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33034	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TTACGAGTCTGGGTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33035	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TAAATGTTAAGGATTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33036	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				TAAATGTTAAGGATTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33037	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TAAATGTTAAGGATTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33038	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				AGGGCTCTGTCTGTAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33039	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				AGGGCTCTGTCTGTAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33040	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				AGGGCTCTGTCTGTAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33041	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				AGAGTCCTCCCAAGTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33042	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				AGAGTCCTCCCAAGTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33043	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				AGAGTCCTCCCAAGTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33044	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GCGCTCTGCCCGACACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33045	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				GCGCTCTGCCCGACACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33046	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GCGCTCTGCCCGACACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33047	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GAGCTCCTGACTTTTGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33048	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				GAGCTCCTGACTTTTGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33049	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				GAGCTCCTGACTTTTGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33050	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TTTGAGGCTTTAAACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33051	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				TTTGAGGCTTTAAACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33052	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TTTGAGGCTTTAAACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33053	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TCTGCATATGGTAGGAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33054	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				TCTGCATATGGTAGGAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33055	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				TCTGCATATGGTAGGAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33056	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				CTAGAAAAAAGAAGAGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33057	hg19	N/A	enh13582	fant37239	Enhatls26845	enhancer	E_164				CTAGAAAAAAGAAGAGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24477	chr10	123819001	123824403	122059486	122064888	33058	hg19	N/A	enh13582	N/A	Enhatls26845	enhancer	E_164				CTAGAAAAAAGAAGAGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					TACC2	chr10	121989162	122254545	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6912
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33059	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				GTTTAGTTGGTGTTTATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33060	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				TTAGTTGCATCAAACAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33061	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				TTAGAGCTAGAGAACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33062	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				ACAGGGGACACTGAGTAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33063	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				GTAATGAGGAGCTCACGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33064	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				GGAATGGTCAGTATCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24526	chr10	124201330	124202829	122441814	122443313	33065	hg19	N/A	enh13588	N/A	Enhatls26898	enhancer	E_165				TCTTGTCTTGAGGAAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					ARMS2	chr10	122454652	122457352	5374				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6961
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33066	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TATCACTTCACTGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33067	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				TATCACTTCACTGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33068	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TATCACTTCACTGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33069	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				TATCACTTCACTGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33070	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TATCACTTCACTGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33071	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TCCCGCGTGCGGGGTACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33072	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				TCCCGCGTGCGGGGTACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33073	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TCCCGCGTGCGGGGTACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33074	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				TCCCGCGTGCGGGGTACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33075	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				TCCCGCGTGCGGGGTACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33076	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCCGCCCGGGAAGCTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33077	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				CCCGCCCGGGAAGCTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33078	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCCGCCCGGGAAGCTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33079	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				CCCGCCCGGGAAGCTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33080	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCCGCCCGGGAAGCTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33081	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACTAATGGAACTTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33082	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				ACTAATGGAACTTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33083	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACTAATGGAACTTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33084	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				ACTAATGGAACTTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33085	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACTAATGGAACTTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33086	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GACCGCCCGCGGAGGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33087	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GACCGCCCGCGGAGGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33088	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GACCGCCCGCGGAGGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33089	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GACCGCCCGCGGAGGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33090	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GACCGCCCGCGGAGGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33091	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGGCACGGCGCCCGGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33092	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GGGCACGGCGCCCGGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33093	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGGCACGGCGCCCGGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33094	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GGGCACGGCGCCCGGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33095	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGGCACGGCGCCCGGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33096	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACAGGGCGAGGGCCGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33097	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				ACAGGGCGAGGGCCGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33098	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACAGGGCGAGGGCCGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33099	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				ACAGGGCGAGGGCCGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33100	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				ACAGGGCGAGGGCCGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33101	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCAGCGGTCTGGGCACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33102	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GCAGCGGTCTGGGCACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33103	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCAGCGGTCTGGGCACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33104	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GCAGCGGTCTGGGCACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33105	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCAGCGGTCTGGGCACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33106	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCGCAGCCGGAGCACTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33107	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				CCGCAGCCGGAGCACTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33108	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCGCAGCCGGAGCACTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33109	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				CCGCAGCCGGAGCACTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33110	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CCGCAGCCGGAGCACTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33111	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GAGGTGTGCGGCGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33112	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GAGGTGTGCGGCGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33113	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GAGGTGTGCGGCGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33114	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GAGGTGTGCGGCGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33115	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GAGGTGTGCGGCGCGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33116	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCCGCCGCACCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33117	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GCGCCGCCGCACCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33118	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCCGCCGCACCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33119	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GCGCCGCCGCACCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33120	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCCGCCGCACCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33121	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCCAGCAGCGAGCCGGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33122	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GCCAGCAGCGAGCCGGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33123	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCCAGCAGCGAGCCGGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33124	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GCCAGCAGCGAGCCGGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33125	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCCAGCAGCGAGCCGGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33126	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGTGCAGCCTCTCGGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33127	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GGTGCAGCCTCTCGGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33128	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGTGCAGCCTCTCGGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33129	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GGTGCAGCCTCTCGGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33130	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GGTGCAGCCTCTCGGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33131	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGCGGAGTACCTTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33132	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				CGGCGGAGTACCTTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33133	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGCGGAGTACCTTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33134	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				CGGCGGAGTACCTTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33135	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGCGGAGTACCTTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33136	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGGACTGGTGGGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33137	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				CGGGACTGGTGGGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33138	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGGACTGGTGGGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33139	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				CGGGACTGGTGGGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33140	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CGGGACTGGTGGGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33141	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CTCGGTTCCGAGGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33142	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				CTCGGTTCCGAGGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33143	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CTCGGTTCCGAGGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33144	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				CTCGGTTCCGAGGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33145	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				CTCGGTTCCGAGGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	indirect	Non Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33146	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCTGTGTGGTTGCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33147	hg19	N/A	N/A	fant37248	Enhatls26900	enhancer	E_166				GCGCTGTGTGGTTGCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33148	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCTGTGTGGTTGCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33149	hg19	N/A	N/A	fant37249	Enhatls26900	enhancer	E_166				GCGCTGTGTGGTTGCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-24528	chr10	124220232	124223169	122460716	122463653	33150	hg19	N/A	N/A	N/A	Enhatls26900	enhancer	E_166				GCGCTGTGTGGTTGCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FGFR2	direct	Highly Significant	NA					HTRA1	chr10	122458550	122514907	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6963
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33151	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33152	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33153	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33154	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33155	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33156	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33157	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CATCTGCCCTCCCCAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33158	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33159	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33160	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33161	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33162	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33163	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33164	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGATACTGTAATGGTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33165	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33166	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33167	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33168	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33169	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33170	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33171	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGTGATGATCACTGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33172	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33173	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33174	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33175	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33176	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33177	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33178	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAAATGCAAGATGTTGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33179	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33180	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33181	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33182	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33183	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33184	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33185	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTATAACTTCTGTTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33186	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33187	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33188	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33189	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33190	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33191	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33192	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CAGCCCTACGGCTTAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33193	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33194	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33195	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33196	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33197	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33198	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33199	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GTGACTCAGCCCTAAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33200	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33201	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33202	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33203	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33204	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33205	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33206	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				AAGGGGGCTGCGGCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33207	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33208	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33209	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33210	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33211	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33212	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33213	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGGCTGGCACAGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33214	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33215	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33216	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33217	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33218	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33219	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33220	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGATGCTGGGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33221	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33222	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33223	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33224	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33225	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33226	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33227	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				CCCAAACCTCGCCTGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33228	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33229	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33230	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33231	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33232	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33233	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33234	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGGCGCCCAGGCACAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33235	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33236	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33237	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33238	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33239	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33240	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33241	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TGCCATGTCCTGGACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33242	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33243	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33244	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33245	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33246	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33247	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33248	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				GGGTGAGCTGGATAACCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33249	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	4418				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33250	hg19	N/A	enh13684	fant37650	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6087				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33251	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	6309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33252	hg19	N/A	enh13684	fant37651	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	7893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33253	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8233				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33254	hg19	N/A	enh13684	fant37652	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	8958				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1791284	1796532	1770054	1775302	33255	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_167				TCAGTCTGTCTCTCTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33256	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33257	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33258	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33259	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33260	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33261	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33262	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33263	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33264	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGGTGGCTGCACCAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33265	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33266	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33267	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33268	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33269	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33270	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33271	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33272	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33273	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCTCATTGTGGGGGTGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	indirect	Non Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33274	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33275	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33276	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33277	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33278	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33279	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33280	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33281	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33282	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CTGTGGGTGGGAGGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33283	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33284	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33285	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33286	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33287	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33288	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33289	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33290	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33291	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGAGCTGGCATCCCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33292	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33293	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33294	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33295	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33296	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33297	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33298	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33299	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33300	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGCAGCTGGACAAACGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33301	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33302	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33303	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33304	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33305	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33306	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33307	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33308	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33309	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GGGCATTGTTCACAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33310	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33311	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33312	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33313	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33314	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33315	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33316	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33317	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33318	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				GCTTGGGGTCCCTCCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33319	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33320	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33321	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33322	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33323	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33324	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33325	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33326	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33327	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCGGGTAACTCGAGGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33328	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	9173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33329	hg19	N/A	enh13684	fant37653	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	16569				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33330	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17223				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33331	hg19	N/A	enh13684	fant37654	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33332	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	17878				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33333	hg19	N/A	enh13684	fant37655	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33334	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	18775				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33335	hg19	N/A	enh13684	fant37656	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-25730	chr11	1797686	1805987	1776456	1784757	33336	hg19	N/A	enh13684	N/A	Enhatls28082	enhancer	E_168				CCAGGTGTGTGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CTSD	chr11	1752751	1764573	19246				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	399
enhrx-lit672	chr11	1884100	1887518	1862870	1866288	33337	hg19					enhancer	E_169				TTGTGGATGCTGGGGATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit673	chr11	1884100	1887518	1862870	1866288	33338	hg19					enhancer	E_169				GGCACAACCCAGGAGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit674	chr11	1884100	1887518	1862870	1866288	33339	hg19					enhancer	E_169				ACCCAGTCTGGTGTGTATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit675	chr11	1884100	1887518	1862870	1866288	33340	hg19					enhancer	E_169				CCGGGGGTGGCGGCAACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit676	chr11	1884100	1887518	1862870	1866288	33341	hg19					enhancer	E_169				GCTGTGAGCAGACGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit677	chr11	1884100	1887518	1862870	1866288	33342	hg19					enhancer	E_169				CAGGGTCATGATAGCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit678	chr11	1884100	1887518	1862870	1866288	33343	hg19					enhancer	E_169				AGGACTAATTGGGTGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit679	chr11	1884100	1887518	1862870	1866288	33344	hg19					enhancer	E_169				CAGCGAGCTGGGCAAACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit680	chr11	1884100	1887518	1862870	1866288	33345	hg19					enhancer	E_169				GCTAGTGGCCGGACGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit681	chr11	1884100	1887518	1862870	1866288	33346	hg19					enhancer	E_169				AAGCCCAACCAGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit682	chr11	1884100	1887518	1862870	1866288	33347	hg19					enhancer	E_169				AAGGGGGGCCTGGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit683	chr11	1884100	1887518	1862870	1866288	33348	hg19					enhancer	E_169				GGGAACAGAGAGGGTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit684	chr11	1884100	1887518	1862870	1866288	33349	hg19					enhancer	E_169				AGAGGCCGGGAATGAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33350	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				CCCAGAGAGAAAGTGCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33351	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				CCCAGAGAGAAAGTGCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33352	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				CCCAGAGAGAAAGTGCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33353	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				CCCAGAGAGAAAGTGCCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33354	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ACCCAGTAAGGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33355	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ACCCAGTAAGGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33356	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ACCCAGTAAGGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33357	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ACCCAGTAAGGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33358	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ATCGTGTGACTGCCATCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33359	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ATCGTGTGACTGCCATCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33360	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ATCGTGTGACTGCCATCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33361	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ATCGTGTGACTGCCATCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33362	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				TGGGCCAGCCGGCCTGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33363	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				TGGGCCAGCCGGCCTGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33364	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				TGGGCCAGCCGGCCTGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33365	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				TGGGCCAGCCGGCCTGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33366	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ATCAGGCCAAATTATTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33367	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ATCAGGCCAAATTATTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33368	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ATCAGGCCAAATTATTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33369	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ATCAGGCCAAATTATTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33370	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				GACTGACACTGAGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33371	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				GACTGACACTGAGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33372	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				GACTGACACTGAGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33373	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				GACTGACACTGAGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33374	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				TGGGTGGACATCCCGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33375	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				TGGGTGGACATCCCGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33376	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				TGGGTGGACATCCCGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33377	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				TGGGTGGACATCCCGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33378	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				TGGCTGCCTGGACTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33379	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				TGGCTGCCTGGACTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33380	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				TGGCTGCCTGGACTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33381	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				TGGCTGCCTGGACTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33382	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				GGAGCCTGAAGGGTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33383	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				GGAGCCTGAAGGGTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33384	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				GGAGCCTGAAGGGTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33385	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				GGAGCCTGAAGGGTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33386	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				CACAGCCTAGAAATGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33387	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				CACAGCCTAGAAATGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33388	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				CACAGCCTAGAAATGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33389	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				CACAGCCTAGAAATGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33390	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				CCAGGGGGACACGCTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33391	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				CCAGGGGGACACGCTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33392	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				CCAGGGGGACACGCTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33393	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				CCAGGGGGACACGCTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33394	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				GCTAATTGCAAAGCCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33395	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				GCTAATTGCAAAGCCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33396	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				GCTAATTGCAAAGCCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33397	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				GCTAATTGCAAAGCCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33398	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				AAAGGCCCTGTCCCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33399	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				AAAGGCCCTGTCCCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33400	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				AAAGGCCCTGTCCCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33401	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				AAAGGCCCTGTCCCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33402	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ATCTCCTTGGCCCAAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33403	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ATCTCCTTGGCCCAAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33404	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ATCTCCTTGGCCCAAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33405	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ATCTCCTTGGCCCAAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33406	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ATTGACTGCCCGCTGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33407	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ATTGACTGCCCGCTGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33408	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ATTGACTGCCCGCTGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33409	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ATTGACTGCCCGCTGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25761	chr11	1966345	1976993	1945115	1955763	33410	hg19	N/A	N/A	N/A	Enhatls28119	enhancer	E_170				ACGGAGCTCGGCCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	430
enhrx-25762	chr11	1966345	1976993	1945115	1955763	33411	hg19	N/A	N/A	N/A	Enhatls28120	enhancer	E_170				ACGGAGCTCGGCCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	431
enhrx-25763	chr11	1966345	1976993	1945115	1955763	33412	hg19	N/A	N/A	N/A	Enhatls28121	enhancer	E_170				ACGGAGCTCGGCCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	432
enhrx-25764	chr11	1966345	1976993	1945115	1955763	33413	hg19	N/A	N/A	N/A	Enhatls28122	enhancer	E_170				ACGGAGCTCGGCCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					MRPL23	chr11	1947277	1984522	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	433
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33414	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33415	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33416	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33417	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33418	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33419	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33420	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				TCTGTCTCCATTCCAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33421	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33422	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33423	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33424	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33425	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33426	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33427	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GCCGGTTGTCTGGCCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33428	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33429	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33430	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33431	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33432	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33433	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33434	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GCTCTGCTTCCCCAGTCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33435	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33436	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33437	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33438	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33439	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33440	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33441	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				AGGGCAGGAAGAGCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33442	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33443	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33444	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33445	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33446	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33447	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33448	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				AGAGTGACAACTCCTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33449	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33450	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33451	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33452	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33453	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33454	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33455	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				CCATGGCCCAAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33456	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33457	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33458	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33459	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33460	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33461	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33462	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GGAGGTCCGAGCCAACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33463	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33464	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33465	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33466	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33467	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33468	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33469	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				CTGTGAGTGTGAAATGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33470	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33471	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33472	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33473	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33474	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33475	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33476	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GGACAAGGCTGGCTGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33477	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33478	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33479	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33480	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33481	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33482	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33483	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GTCAGGAGCCAAGTTTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33484	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33485	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33486	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33487	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33488	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33489	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33490	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				CGGCGGTCCTCATTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33491	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33492	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33493	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33494	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33495	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33496	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33497	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				GAGTGGCTAGAGCGGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33498	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33499	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33500	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33501	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33502	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33503	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33504	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				ACAGTCAAGACACATGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25785	chr11	2324694	2337399	2303464	2316169	33505	hg19	N/A	N/A	N/A	Enhatls28147	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	454
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33506	hg19	N/A	N/A	N/A	Enhatls28148	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33507	hg19	N/A	enh109471	N/A	Enhatls28148	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33508	hg19	N/A	enh109471	N/A	N/A	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33509	hg19	N/A	enh109471	N/A	Enhatls28149	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25786	chr11	2324694	2337399	2303464	2316169	33510	hg19	N/A	N/A	N/A	Enhatls28149	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	455
enhrx-25787	chr11	2324694	2337399	2303464	2316169	33511	hg19	N/A	N/A	N/A	Enhatls28150	enhancer	E_173				TGGTCTCCTGGCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					TSPAN32	chr11	2302012	2318204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	456
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33512	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				GCCTTGACACCCTCCACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33513	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				GCCTTGACACCCTCCACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33514	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				GCCTTGACACCCTCCACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33515	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				GCCTTGACACCCTCCACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33516	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				CCAAGGATAGGTCCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33517	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				CCAAGGATAGGTCCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33518	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				CCAAGGATAGGTCCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33519	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				CCAAGGATAGGTCCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33520	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				GCCTTGCACGACCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33521	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				GCCTTGCACGACCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33522	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				GCCTTGCACGACCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33523	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				GCCTTGCACGACCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33524	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				AGAATGACTCAGAGATGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33525	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				AGAATGACTCAGAGATGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33526	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				AGAATGACTCAGAGATGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33527	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				AGAATGACTCAGAGATGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33528	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				AGGACAGGGCTGGGGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33529	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				AGGACAGGGCTGGGGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33530	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				AGGACAGGGCTGGGGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33531	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				AGGACAGGGCTGGGGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25834	chr11	2789934	2790731	2768704	2769501	33532	hg19	N/A	N/A	N/A	Enhatls28189	enhancer	E_175				TCCATCCTCCCAACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	503
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33533	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				TCCATCCTCCCAACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33534	hg19	N/A	N/A	fant37720	Enhatls28190	enhancer	E_175				TCCATCCTCCCAACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25835	chr11	2789934	2790731	2768704	2769501	33535	hg19	N/A	N/A	N/A	Enhatls28190	enhancer	E_175				TCCATCCTCCCAACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					KCNQ1	chr11	2444653	2849105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	504
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33536	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33537	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33538	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33539	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33540	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33541	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33542	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33543	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				GGGCACCTCCTCCTCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33544	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33545	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33546	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33547	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33548	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33549	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33550	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33551	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				ATGAGATGACCAGGAGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33552	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33553	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33554	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33555	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33556	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33557	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33558	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33559	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				TTGCGGCATGTGGTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33560	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33561	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33562	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33563	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33564	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33565	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33566	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33567	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				GGGCTGAGAGGGCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33568	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33569	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33570	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33571	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33572	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33573	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33574	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33575	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				TGTCAGGCCTCCTTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33576	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33577	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33578	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33579	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33580	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33581	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33582	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33583	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				ATGTGCTGATGAGGGGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33584	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33585	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33586	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33587	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33588	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33589	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33590	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33591	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				GCGGCGTCCACTGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33592	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33593	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33594	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33595	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33596	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33597	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33598	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33599	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				TTCGGGGAGGCACATGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33600	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33601	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33602	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33603	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33604	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33605	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33606	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33607	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				TGATGCAAGCTACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33608	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33609	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33610	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33611	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33612	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33613	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33614	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33615	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				AATGTGTGTCGGGTTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33616	hg19	N/A	enh47459	N/A	N/A	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	1641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33617	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	4991				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33618	hg19	N/A	enh47459	fant37731	Enhatls28199	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					CDKN1C	chr11	2883212	2885775	6613				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33619	hg19	N/A	enh47459	N/A	Enhatls28199	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5116				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25842	chr11	2911002	2926345	2889772	2905115	33620	hg19	N/A	N/A	N/A	Enhatls28199	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-25843	chr11	2911002	2926345	2889772	2905115	33621	hg19	N/A	N/A	fant37732	N/A	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	558				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-25844	chr11	2911002	2926345	2889772	2905115	33622	hg19	N/A	N/A	N/A	Enhatls28200	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-25845	chr11	2911002	2926345	2889772	2905115	33623	hg19	N/A	N/A	N/A	Enhatls28201	enhancer	E_176				GGGGTCTCCCGAATGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	514
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33624	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33625	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33626	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33627	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33628	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33629	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GGGCGAGAGCTGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33630	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33631	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33632	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33633	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33634	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33635	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				AGCGGAAGTCGATCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33636	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33637	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33638	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33639	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33640	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33641	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GCTCCACGCAGTCCACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33642	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33643	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33644	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33645	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33646	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33647	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GCTATGGAAGAAGAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33648	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33649	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33650	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33651	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33652	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33653	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CCCGACGAGGTGCTACGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33654	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33655	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33656	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33657	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33658	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33659	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CAGCTATAAAGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33660	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33661	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33662	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33663	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33664	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33665	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CTTGGGGAGGGTATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33666	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33667	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33668	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33669	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33670	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33671	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CGGGACCTCGAGTCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33672	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33673	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33674	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33675	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33676	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33677	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GCCCGCGATGACTCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33678	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33679	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33680	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33681	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33682	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33683	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CCGGGGCAGAAGGAGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33684	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33685	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33686	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33687	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33688	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33689	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GCTCCTATCTTGCCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33690	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33691	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33692	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33693	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33694	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33695	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CGTGTTCCCTAATCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33696	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33697	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33698	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33699	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33700	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33701	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				TCGGGACACTACGAGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33702	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33703	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33704	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33705	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33706	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33707	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CCTCTCTCCGGTCCGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33708	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33709	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33710	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33711	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33712	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33713	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				TTTCCAGCTGGGCAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33714	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33715	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33716	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33717	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33718	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33719	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				GAGACGTGGAGTAGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25852	chr11	2944029	2956445	2922799	2935215	33720	hg19	N/A	N/A	N/A	Enhatls28208	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					SLC22A18	chr11	2899720	2925246	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	521
enhrx-25853	chr11	2944029	2956445	2922799	2935215	33721	hg19	N/A	N/A	N/A	Enhatls28209	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	522
enhrx-25854	chr11	2944029	2956445	2922799	2935215	33722	hg19	N/A	N/A	N/A	Enhatls28210	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	523
enhrx-25855	chr11	2944029	2956445	2922799	2935215	33723	hg19	N/A	N/A	fant37734	N/A	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-25856	chr11	2944029	2956445	2922799	2935215	33724	hg19	N/A	N/A	fant37735	N/A	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	1410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	525
enhrx-25857	chr11	2944029	2956445	2922799	2935215	33725	hg19	N/A	N/A	N/A	Enhatls28211	enhancer	E_177				CCCCTAGCTGCGCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					PHLDA2	chr11	2928272	2929420	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33726	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GGGGCCTCAGGTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33727	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GGGGCCTCAGGTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33728	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GGGGCCTCAGGTGCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33729	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CAGTGCCTCACTGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33730	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				CAGTGCCTCACTGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33731	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CAGTGCCTCACTGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33732	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCAGGGTCTGGGTTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33733	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				CCAGGGTCTGGGTTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33734	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCAGGGTCTGGGTTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33735	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCAAGTTTCCAAATCTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33736	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				CCAAGTTTCCAAATCTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33737	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCAAGTTTCCAAATCTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33738	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TGTGTGGGTCCGCCCTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33739	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				TGTGTGGGTCCGCCCTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33740	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TGTGTGGGTCCGCCCTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33741	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GCTGACTCATGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33742	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GCTGACTCATGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33743	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GCTGACTCATGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33744	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GGCCTGGACGCCTCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33745	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GGCCTGGACGCCTCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33746	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GGCCTGGACGCCTCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33747	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GAGATGCAGACCCGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33748	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GAGATGCAGACCCGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33749	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GAGATGCAGACCCGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33750	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GCGCATCAGAAGCTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33751	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GCGCATCAGAAGCTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33752	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GCGCATCAGAAGCTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33753	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TGGGGGGCCCAAGGGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33754	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				TGGGGGGCCCAAGGGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33755	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TGGGGGGCCCAAGGGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33756	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCGAAGTCCATGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33757	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				CCGAAGTCCATGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33758	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CCGAAGTCCATGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33759	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				ACTCCAGCTGCAGTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33760	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				ACTCCAGCTGCAGTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33761	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				ACTCCAGCTGCAGTGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33762	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GAACAGCCAGGGGCAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33763	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GAACAGCCAGGGGCAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33764	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GAACAGCCAGGGGCAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33765	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GTCAGAGGTCAGTAATATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33766	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				GTCAGAGGTCAGTAATATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33767	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				GTCAGAGGTCAGTAATATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33768	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CTACCCACCTGGCTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33769	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				CTACCCACCTGGCTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33770	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				CTACCCACCTGGCTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33771	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TCCAAGCTTGCCCCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33772	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				TCCAAGCTTGCCCCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33773	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TCCAAGCTTGCCCCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33774	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TCCCACTCTCAAAATGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3820				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33775	hg19	N/A	enh13707	fant37736	Enhatls28211	enhancer	E_178				TCCCACTCTCAAAATGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	3601				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-25857	chr11	2961004	2963640	2939774	2942410	33776	hg19	N/A	enh13707	N/A	Enhatls28211	enhancer	E_178				TCCCACTCTCAAAATGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL2	direct	Highly Significant	NA					NAP1L4	chr11	2944430	2992377	686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	526
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33777	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				GGGTGATCGCTAGAGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33778	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				GGGTGATCGCTAGAGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33779	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				GGGTGATCGCTAGAGAGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33780	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				TATAAATAGGCTTAGACACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33781	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				TATAAATAGGCTTAGACACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33782	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				TATAAATAGGCTTAGACACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33783	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				CATTTAGCATAATGTTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33784	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				CATTTAGCATAATGTTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33785	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				CATTTAGCATAATGTTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33786	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				CCCAAAGTCCGTCAACTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33787	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				CCCAAAGTCCGTCAACTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33788	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				CCCAAAGTCCGTCAACTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33789	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				AGTTTTTGTGTAGGTGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33790	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				AGTTTTTGTGTAGGTGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33791	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				AGTTTTTGTGTAGGTGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33792	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				ACCTTTTGAGAACGTGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33793	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				ACCTTTTGAGAACGTGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33794	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				ACCTTTTGAGAACGTGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33795	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				TACTTTAGAAGTGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33796	hg19	N/A	enh13813	fant38068	Enhatls29351	enhancer	E_181				TACTTTAGAAGTGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16923122	16925378	16901575	16903831	33797	hg19	N/A	enh13813	N/A	Enhatls29351	enhancer	E_181				TACTTTAGAAGTGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33798	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				GATGCTCCAGAACAGGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33799	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				ATGGTTTGCACTGGGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33800	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				GAGGCTGCTAATAGTAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33801	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				GATCCCCACAGATTCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33802	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				AGTTCAGACGGAGACAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33803	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				CGTCATGGAGCCGGAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33804	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				GTTTTTAAATAAGGGCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33805	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				ACACCAGGAAGGACAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33806	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				ATACAAATAGATATCTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33807	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				AGGGAGCCTGCATTTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-26921	chr11	16997227	17005256	16975680	16983709	33808	hg19	N/A	enh13816	N/A	Enhatls29351	enhancer	E_182				CAAGCTTGCCTGTGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					PLEKHA7	chr11	16777296	17014415	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33809	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33810	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33811	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33812	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33813	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33814	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				TCTCACTATCATCCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33815	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33816	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33817	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33818	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33819	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33820	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				ACAGCCAGCCCTCCTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33821	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33822	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33823	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33824	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33825	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33826	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				ACCCGACCCCCACCACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33827	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33828	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33829	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33830	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33831	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33832	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				GTTTGCAGCCAAAAGACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33833	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33834	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33835	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33836	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33837	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33838	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				AGCTTTTAAAGCTACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33839	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33840	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33841	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33842	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33843	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33844	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CAACTCCAAGCAAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33845	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33846	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33847	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33848	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33849	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33850	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CAGGCATGTTGTGAAGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33851	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33852	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33853	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33854	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33855	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33856	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CCACCACTGAAACACTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33857	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33858	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33859	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33860	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33861	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33862	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				GAGGCCCTGCAGCATAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33863	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33864	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33865	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33866	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33867	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33868	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CTCCAGTTTTAGCCACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33869	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33870	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33871	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33872	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33873	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33874	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				GCTCGGCCTTGTACACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33875	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33876	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33877	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33878	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33879	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33880	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CTGGACCTTCCTGTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33881	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33882	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33883	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33884	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33885	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33886	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				ATCCTCCCAGACTGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33887	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33888	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33889	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33890	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33891	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33892	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				TTGGCCACTTTCCCGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33893	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33894	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33895	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33896	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33897	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33898	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				CCTGACCAGAAGAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33899	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33900	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33901	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33902	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33903	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33904	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				GCCACCACAGCTACACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33905	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					GTF2H1	chr11	18322294	18367045	10394				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33906	hg19	N/A	enh13826	fant38101	Enhatls29589	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	10306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33907	hg19	N/A	enh13826	N/A	Enhatls29589	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	7992				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27155	chr11	18403415	18418553	18381868	18397006	33908	hg19	N/A	N/A	N/A	Enhatls29589	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	5177				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1824
enhrx-27156	chr11	18403415	18418553	18381868	18397006	33909	hg19	N/A	N/A	N/A	Enhatls29590	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1825
enhrx-27157	chr11	18403415	18418553	18381868	18397006	33910	hg19	N/A	N/A	N/A	Enhatls29591	enhancer	E_184				ACTCCTCATAAGAGAATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYOD1	direct	Highly Significant	NA					LDHA	chr11	18394559	18408425	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1826
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33911	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CTATGTCTCTCCCACATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33912	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				CTATGTCTCTCCCACATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33913	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CTATGTCTCTCCCACATTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33914	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GTGGACATGATTGATGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33915	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GTGGACATGATTGATGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33916	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GTGGACATGATTGATGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33917	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				ACAGGGCATCGAAAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33918	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				ACAGGGCATCGAAAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33919	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				ACAGGGCATCGAAAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33920	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				TTTCCGGCAGAGAAGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33921	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				TTTCCGGCAGAGAAGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33922	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				TTTCCGGCAGAGAAGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33923	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGAACTCCCTGGTTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33924	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				AGAACTCCCTGGTTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33925	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGAACTCCCTGGTTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33926	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGTCCTTGCCCTAAGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33927	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				AGTCCTTGCCCTAAGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33928	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGTCCTTGCCCTAAGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33929	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				ATAGGACTCTCTGTGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33930	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				ATAGGACTCTCTGTGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33931	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				ATAGGACTCTCTGTGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33932	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GAGTAAATCCTGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33933	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GAGTAAATCCTGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33934	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GAGTAAATCCTGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33935	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CTGCAAGCATCCAATCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33936	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				CTGCAAGCATCCAATCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33937	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CTGCAAGCATCCAATCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33938	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GATCCAAGTTCCAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33939	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GATCCAAGTTCCAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33940	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GATCCAAGTTCCAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33941	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GCTTCCTGCTTTCCGCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33942	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GCTTCCTGCTTTCCGCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33943	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GCTTCCTGCTTTCCGCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33944	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GCGCTGGTAGTCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33945	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GCGCTGGTAGTCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33946	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GCGCTGGTAGTCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33947	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GTTCCAGGAAAGCTGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33948	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				GTTCCAGGAAAGCTGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33949	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				GTTCCAGGAAAGCTGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33950	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGAGAGAATTTATAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33951	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				AGAGAGAATTTATAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33952	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				AGAGAGAATTTATAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33953	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				TTATTGAGAGCATCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33954	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				TTATTGAGAGCATCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33955	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				TTATTGAGAGCATCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33956	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CAAGCGGATGGCTTGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	41360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33957	hg19	N/A	enh13965	fant38773	Enhatls31966	enhancer	E_188				CAAGCGGATGGCTTGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46013				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29417	chr11	61778469	61786287	62010997	62018815	33958	hg19	N/A	enh13965	N/A	Enhatls31966	enhancer	E_188				CAAGCGGATGGCTTGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					FTH1	chr11	61959717	61967634	46208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4086
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33959	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33960	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33961	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33962	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33963	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33964	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33965	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGTCCTGTTCTTATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33966	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33967	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33968	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33969	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33970	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33971	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33972	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCAAGTGGGACCGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33973	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33974	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33975	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33976	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33977	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33978	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33979	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACTCTCCCGTCTCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33980	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33981	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33982	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33983	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33984	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33985	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33986	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCCAGCAGAAGAGTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33987	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33988	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33989	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33990	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33991	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33992	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33993	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATGAAAGCTATAATGAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33994	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33995	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33996	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33997	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33998	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	33999	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34000	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CCTGTCCTTGGGAGCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34001	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34002	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34003	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34004	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34005	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34006	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34007	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCGTTTCGCTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34008	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34009	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34010	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34011	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34012	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34013	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34014	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTTGCCGTGAACTATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34015	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34016	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34017	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34018	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34019	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34020	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34021	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATGTCTTTGTGGTTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34022	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34023	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34024	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34025	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34026	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34027	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34028	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGAATTTCCTGAATAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34029	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34030	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34031	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34032	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34033	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34034	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34035	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTAAAATGCAGGGGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34036	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34037	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34038	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34039	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34040	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34041	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34042	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGTAAGACGCTGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34043	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34044	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34045	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34046	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34047	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34048	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34049	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGGCCCAGCGGGTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34050	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34051	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34052	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34053	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34054	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34055	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34056	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACAGTTATTCAAAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34057	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34058	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34059	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34060	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34061	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34062	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34063	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CTGTGGATAATTACAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34064	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34065	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34066	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34067	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34068	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34069	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34070	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ATCTGCCAGTCCTACAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34071	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34072	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34073	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34074	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34075	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34076	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34077	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AGTTGATTATAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34078	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34079	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34080	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34081	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34082	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34083	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34084	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GACGCCAGTTTGCGTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34085	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34086	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34087	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34088	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34089	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34090	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34091	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CAGCATTTCCGGGCAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34092	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34093	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34094	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34095	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34096	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34097	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34098	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CGGAGCAGTCATCTTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34099	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34100	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34101	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34102	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34103	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34104	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34105	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAGATGGACAGGGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34106	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34107	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34108	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34109	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34110	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34111	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34112	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GGGAGATGACCCAGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34113	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34114	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34115	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34116	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34117	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34118	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34119	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				CACGCACAGCCCCCTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34120	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34121	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34122	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34123	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34124	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34125	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34126	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACGGCATGGGAAGTCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34127	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34128	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34129	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34130	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34131	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34132	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34133	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCAATCCAAGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34134	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34135	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34136	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34137	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34138	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34139	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34140	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GATAAAGGAAGGCCAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34141	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34142	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34143	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34144	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34145	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34146	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34147	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TTTCTGGCAGGCATTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34148	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34149	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34150	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34151	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34152	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34153	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34154	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GAAGGAGGAGATTTGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34155	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34156	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34157	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34158	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34159	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34160	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34161	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TGTCCTGGCACAGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34162	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34163	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34164	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34165	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34166	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34167	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34168	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				TCTTTGAGAATTTATAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34169	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34170	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34171	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34172	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34173	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34174	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34175	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTCACAGTATTTTAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34176	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34177	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34178	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34179	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34180	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34181	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34182	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				AAAATTCACGAAACAAAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34183	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34184	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34185	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34186	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34187	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34188	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34189	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				GTGGATCGCTTGAGGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34190	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34191	hg19	N/A	enh13972	fant38790	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34192	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34193	hg19	N/A	enh13972	fant38791	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34194	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34195	hg19	N/A	enh13972	fant38792	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29456	chr11	62222575	62242917	62455103	62475445	34196	hg19	N/A	enh13972	N/A	Enhatls32008	enhancer	E_189				ACAAAAATTAGCCGAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					AHNAK	chr11	62433541	62556235	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4125
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34197	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GGTCCAGTAAGCTCACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34198	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GTTCAGTGTCCACGGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34199	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				CGGTGCTTCCAGCTCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34200	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				TCTCAGCCGCCGCCCTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34201	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GGCTTTACTAAACCGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34202	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				CGTCGCTCGGATCTACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34203	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				CAGAGTGTCAAGAGACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34204	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GTGAGGAGCCCGGAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34205	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				AACTCTGCACAAGATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34206	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				CCAATGAGACAGCTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34207	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GCACTCCAAATTATCGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34208	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				GCATGACAGAAGCACTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34209	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				AACGTGCTCCGGAAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29489	chr11	62412173	62416032	62644701	62648560	34210	hg19	N/A	N/A	N/A	Enhatls32045	enhancer	E_190				CGTCCACTCTCCTTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					GANAB	chr11	62624825	62646726	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4158
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34211	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				CCTGGGACCGCTGCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34212	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				ATAGTACCCCACGAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34213	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				AGTGGCTCCCTGAGAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34214	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				CCTGTTCTAAGGTTAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34215	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				GTGGGCATCAAGGAAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34216	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				TGGGGCGTAGAGGCATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34217	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				GACCAATCCGTGACAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34218	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				TCGCTTTTGCAGTCAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34219	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				AGAAGCTCAGCCAATCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34220	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				CGGCTCCGAGTCGCTGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34221	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				TTTTCCCTGTCAGCCTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29511	chr11	62520446	62523431	62752974	62755959	34222	hg19	N/A	N/A	N/A	Enhatls32065	enhancer	E_191				TGCTTCACGCCTGTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZBTB3	chr11	62750962	62754184	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4180
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34223	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				GCAGCAGTCAAACCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34224	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				CTCTAAAAGATAATTAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34225	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				GGATACAAGTGATTTTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34226	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				TAGTCTGCAGATAATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34227	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				ATACAAAAGATACTTTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34228	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				CCTAATAGTGCAAACTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34229	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				TGTAATAACAACACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350146	63350576	63582674	63583104	34230	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_194				GGCTACCTGGTGTGTGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34231	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				GCAGCAGTCAAACCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34232	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				CTCTAAAAGATAATTAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34233	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				GGATACAAGTGATTTTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34234	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				TAGTCTGCAGATAATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34235	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				ATACAAAAGATACTTTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34236	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				CCTAATAGTGCAAACTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34237	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				TGTAATAACAACACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29637	chr11	63350596	63351527	63583124	63584055	34238	hg19	N/A	enh13979	N/A	Enhatls32188	enhancer	E_195				GGCTACCTGGTGTGTGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4306
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34239	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34240	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34241	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34242	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34243	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34244	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34245	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				GCAGTCATGCCTCATTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34246	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34247	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34248	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34249	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34250	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34251	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34252	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TGCCACTTTCAGGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34253	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34254	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34255	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34256	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34257	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34258	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34259	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				AAGACAGCCCCACCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34260	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34261	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34262	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34263	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34264	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34265	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34266	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				CTCTGGCACTGTGCGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34267	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34268	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34269	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34270	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34271	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34272	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34273	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TTTGTCTCATCAGAGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34274	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34275	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34276	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34277	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34278	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34279	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34280	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				GCATAGCGATTACACACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34281	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34282	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34283	hg19	N/A	enh64479	fant38831	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34284	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34285	hg19	N/A	enh64479	fant38832	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34286	hg19	N/A	enh64479	N/A	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29638	chr11	63374695	63382460	63607223	63614988	34287	hg19	N/A	N/A	N/A	Enhatls32190	enhancer	E_196				TTAGGAGTAATTAGGTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					PLAAT3	chr11	63573194	63614433	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4307
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34288	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34289	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34290	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34291	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34292	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34293	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34294	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34295	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CGTAATATCTCCTCACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34296	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34297	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34298	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34299	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34300	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34301	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34302	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34303	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TCACAAAGCACCTTGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34304	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34305	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34306	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34307	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34308	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34309	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34310	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34311	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TTTTTATTGGAGTCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34312	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34313	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34314	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34315	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34316	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34317	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34318	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34319	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TTTAACGGTAGAAATGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34320	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34321	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34322	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34323	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34324	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34325	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34326	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34327	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				ATTAGCCGCAGTCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34328	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34329	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34330	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34331	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34332	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34333	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34334	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34335	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GCGCTCTTGCAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34336	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34337	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34338	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34339	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34340	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34341	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34342	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34343	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GCGGGTGCCAAAGCGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34344	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34345	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34346	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34347	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34348	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34349	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34350	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34351	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGCCGAGCGCAGCTAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34352	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34353	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34354	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34355	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34356	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34357	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34358	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34359	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GACTTGAGCGAGCCAGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34360	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34361	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34362	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34363	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34364	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34365	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34366	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34367	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGGACGACGAGGAGATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34368	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34369	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34370	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34371	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34372	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34373	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34374	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34375	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				AGCTGCAGCTCTTCGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34376	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34377	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34378	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34379	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34380	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34381	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34382	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34383	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CGCGCGGGGAGCCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34384	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34385	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34386	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34387	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34388	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34389	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34390	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34391	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				CTGAAGCCGTCAGTAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34392	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34393	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34394	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34395	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34396	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34397	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34398	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34399	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				GGGCGGGGAGATAGTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34400	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1789				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34401	hg19	N/A	enh62165	fant38834	N/A	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	1628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34402	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	602				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34403	hg19	N/A	enh62165	fant38835	N/A	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34404	hg19	N/A	enh62165	N/A	N/A	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34405	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34406	hg19	N/A	enh62165	fant38836	Enhatls32202	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29650	chr11	63446824	63450911	63679352	63683439	34407	hg19	N/A	enh62165	N/A	Enhatls32202	enhancer	E_197				TCGATGCATATGGTGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					RTN3	chr11	63681445	63759891	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4319
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34408	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34409	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34410	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34411	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34412	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34413	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GGACGGCAACAGCAATAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34414	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34415	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34416	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34417	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34418	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34419	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TTAGCCCTTTACAAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34420	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34421	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34422	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34423	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34424	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34425	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CTACGGCTCTTGTCCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34426	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34427	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34428	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34429	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34430	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34431	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GTGGGTCCCGTGTGCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34432	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34433	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34434	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34435	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34436	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34437	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GAAAAAGGGAGAAGACCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34438	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34439	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34440	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34441	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34442	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34443	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TGGGGATCCCTCCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34444	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34445	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34446	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34447	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34448	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34449	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CCAATGACCCTGTAAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34450	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34451	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34452	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34453	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34454	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34455	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				AAGCCCATTAAGTCTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34456	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34457	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34458	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34459	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34460	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34461	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GAGAGGCCCCACTAACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34462	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34463	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34464	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34465	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34466	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34467	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CCATTTTTCTAAATCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34468	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34469	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34470	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34471	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34472	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34473	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CAACCCTGTGATTCTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34474	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34475	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34476	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34477	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34478	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34479	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				AGTAGATCCATAGAATCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34480	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34481	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34482	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34483	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34484	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34485	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GTGCGGACATGACCTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34486	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34487	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34488	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34489	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34490	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34491	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TTCTTTGTCTGCAACGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34492	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34493	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34494	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34495	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34496	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34497	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TTAAGAGCCGAAAAAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34498	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34499	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34500	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34501	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34502	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34503	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TGAGGGTTTCCTCCAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34504	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34505	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34506	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34507	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34508	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34509	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TGAGAGCGAACGAGGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34510	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34511	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34512	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34513	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34514	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34515	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				AGGGAGAATGCACCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34516	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34517	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34518	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34519	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34520	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34521	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				ATCGCTTTAAAAACTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34522	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34523	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34524	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34525	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34526	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34527	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CTTCGGGGGCTTTTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34528	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34529	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34530	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34531	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34532	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34533	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CAGGCCCGAGGGGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34534	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34535	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34536	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34537	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34538	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34539	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GTCGGCTCGCGGGGCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34540	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34541	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34542	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34543	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34544	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34545	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TCCGCCGCCGAACAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34546	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34547	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34548	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34549	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34550	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34551	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GCGGTAAGAGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34552	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34553	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34554	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34555	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34556	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34557	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CTGCCGCTCGATCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34558	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34559	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34560	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34561	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34562	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34563	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GCGCAGCGCATGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34564	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34565	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34566	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34567	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34568	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34569	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GCGGGCTGCCGCCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34570	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34571	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34572	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34573	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34574	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34575	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				CGCGGGGCGCATGCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34576	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34577	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34578	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34579	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34580	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34581	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TGGCAGGAGGAAATAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34582	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34583	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34584	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34585	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34586	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34587	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GACCGGAGCCCCGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34588	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34589	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34590	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34591	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34592	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34593	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				GGTGGCCGCGAGCCGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34594	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34595	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34596	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34597	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34598	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34599	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				AGCGCCCGCTGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34600	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34601	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34602	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34603	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34604	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34605	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TCTGGGGCCCCTGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	indirect	Non Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29656	chr11	63530692	63537727	63763220	63770255	34606	hg19	N/A	N/A	N/A	Enhatls32208	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4325
enhrx-29657	chr11	63530692	63537727	63763220	63770255	34607	hg19	N/A	N/A	N/A	Enhatls32209	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4326
enhrx-29658	chr11	63530692	63537727	63763220	63770255	34608	hg19	N/A	N/A	N/A	Enhatls32210	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4327
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34609	hg19	N/A	N/A	N/A	Enhatls32211	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34610	hg19	N/A	enh13982	N/A	Enhatls32211	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-29659	chr11	63530692	63537727	63763220	63770255	34611	hg19	N/A	enh13982	N/A	N/A	enhancer	E_198				TCCCGGGCGGCTCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAF6L	direct	Highly Significant	NA					ZFTA	chr11	63759891	63768775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4328
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34612	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				TAACATCCGGGGAGGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34613	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				TATTAGTTCCCGCATCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34614	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				GTGGCTGGTAACATCCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34615	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				GTCACACTTACTTAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34616	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				ACACCCTGTGATATTATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30616	chr11	67499079	67500130	67731608	67732659	34617	hg19	N/A	N/A	N/A	Enhatls33273	enhancer	E_200				ATTATTATCAACGTACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					ALDH3B2	chr11	67662154	67681224	49396				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5285
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34618	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				AAGGGGTTAAAGGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34619	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				GTACAGTGTCGCGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34620	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				CCTGGAAAATTGCAGCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34621	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				TCCCTTTATTGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34622	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				CACTTAAAGAAAATAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34623	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				CTCAGAACGCATTTTAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34624	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				TCCCCCATGCCCACTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34625	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				CAGCCCAGCCGACTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34626	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				ACAGCAAACGCACGGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	indirect	Non Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34627	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				ACAGACAGTACCAAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30659	chr11	68091557	68098337	68324089	68330869	34628	hg19	N/A	enh14024	N/A	Enhatls33331	enhancer	E_202				GTAGCCCAGTCTGCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5328
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34629	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34630	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34631	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34632	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34633	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34634	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34635	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGCACATCCCTCCTGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34636	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34637	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34638	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34639	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34640	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34641	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34642	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCAGAGCTATGTCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34643	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34644	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34645	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34646	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34647	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34648	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34649	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCCCAGATGAGGCTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34650	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34651	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34652	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34653	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34654	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34655	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34656	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATGTTCGTCTGTCAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34657	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34658	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34659	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34660	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34661	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34662	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34663	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				CTGCCCGTCAGACTCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34664	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34665	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34666	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34667	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34668	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34669	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34670	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TATCAGGGAAGTAGGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34671	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34672	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34673	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34674	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34675	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34676	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34677	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GCGTTGACTTTGCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34678	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34679	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34680	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34681	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34682	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34683	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34684	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TCACACGGTTCAGGAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34685	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34686	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34687	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34688	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34689	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34690	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34691	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TTAATTGAGGTATAACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34692	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34693	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34694	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34695	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34696	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34697	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34698	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				TGTTCTCTGTCTGGACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34699	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34700	hg19	N/A	enh1858	fant39030	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34701	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34702	hg19	N/A	enh1858	fant39031	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34703	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34704	hg19	N/A	enh1858	fant39032	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30663	chr11	68138792	68145274	68371324	68377806	34705	hg19	N/A	enh1858	N/A	Enhatls33335	enhancer	E_203				GATAGAAGTCAGGAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PPP1CA	direct	Highly Significant	NA					LRP5	chr11	68312590	68449275	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5332
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34706	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34707	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34708	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34709	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34710	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34711	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34712	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				CTAGCTCCACTATTTTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34713	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34714	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34715	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34716	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34717	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34718	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34719	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TCTCTTCATGGCCAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34720	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34721	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34722	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34723	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34724	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34725	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34726	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				GCTGCTCTGCCCTGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34727	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34728	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34729	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34730	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34731	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34732	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34733	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				AGGAGCCCGGCCTAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34734	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34735	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34736	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34737	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34738	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34739	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34740	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TGGGAGTCGCTTGGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34741	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34742	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34743	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34744	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34745	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34746	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34747	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				ACAAGGCAATGCCAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30767	chr11	68845876	68848433	69078408	69080965	34748	hg19	N/A	N/A	N/A	Enhatls33446	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5436
enhrx-30768	chr11	68845876	68848433	69078408	69080965	34749	hg19	N/A	N/A	N/A	Enhatls33447	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5437
enhrx-30769	chr11	68845876	68848433	69078408	69080965	34750	hg19	N/A	N/A	N/A	Enhatls33448	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5438
enhrx-30770	chr11	68845876	68848433	69078408	69080965	34751	hg19	N/A	N/A	N/A	Enhatls33449	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34752	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34753	hg19	N/A	N/A	fant39057	Enhatls33450	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30771	chr11	68845876	68848433	69078408	69080965	34754	hg19	N/A	N/A	N/A	Enhatls33450	enhancer	E_204				TTCTGAGTCATTACCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					TPCN2	chr11	69048931	69136316	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34755	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GATCTCTGTGCCCAGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34756	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				GATCTCTGTGCCCAGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34757	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GATCTCTGTGCCCAGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34758	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCCTAATCCTTCAAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34759	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				CCCTAATCCTTCAAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34760	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCCTAATCCTTCAAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34761	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TCACAGTCACCCTGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34762	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				TCACAGTCACCCTGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34763	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TCACAGTCACCCTGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34764	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GGACCTGTAGCCCTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34765	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				GGACCTGTAGCCCTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34766	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GGACCTGTAGCCCTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34767	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCTGACCCCCTTGCCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34768	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				GCTGACCCCCTTGCCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34769	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCTGACCCCCTTGCCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34770	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TGAAAAGCCAAGGAGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34771	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				TGAAAAGCCAAGGAGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34772	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TGAAAAGCCAAGGAGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34773	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCTGCTGCTGCGGAGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34774	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				CCTGCTGCTGCGGAGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34775	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCTGCTGCTGCGGAGACCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34776	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				AGAGAAAGGGCCCAATTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34777	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				AGAGAAAGGGCCCAATTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34778	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				AGAGAAAGGGCCCAATTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34779	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TAATCTGCAAACATCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34780	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				TAATCTGCAAACATCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34781	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TAATCTGCAAACATCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34782	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCACGGAGAGTGGTTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34783	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				GCACGGAGAGTGGTTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34784	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCACGGAGAGTGGTTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34785	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCATGTGAGAGGACAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34786	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				GCATGTGAGAGGACAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34787	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				GCATGTGAGAGGACAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34788	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TCTGCAGCCGGCGCCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34789	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				TCTGCAGCCGGCGCCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34790	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TCTGCAGCCGGCGCCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34791	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCTAGCCCGGCACTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34792	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				CCTAGCCCGGCACTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34793	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CCTAGCCCGGCACTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34794	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TGCCTGAAGTCAGCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34795	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				TGCCTGAAGTCAGCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34796	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				TGCCTGAAGTCAGCCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34797	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CTAGCAGGATCACCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34798	hg19	N/A	N/A	fant39066	Enhatls33459	enhancer	E_205				CTAGCAGGATCACCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68921703	68926444	69154235	69158976	34799	hg19	N/A	N/A	N/A	Enhatls33459	enhancer	E_205				CTAGCAGGATCACCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34800	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				GATCAGAGAGTTGTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34801	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				CATCTCGTCCCGCCTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34802	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				CCAGACTTGCTATTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34803	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				AGGGAGTGAGAGGCTCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34804	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				GTGACTCATCTCCACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34805	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				TGAGGCTCCAGACCTTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34806	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				GACACTCCACCCAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34807	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				ATGGCACGTAGACCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	68933761	68934538	69166293	69167070	34808	hg19	N/A	enh14031	N/A	Enhatls33459	enhancer	E_206				TACAAAAAAATTAACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					SMIM38	chr11	69155477	69162440	1526				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34809	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				GATAACCCCTTTTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34810	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				AGGATAGCTGACAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34811	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				GGCATTCCAGTAACCACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34812	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				TCGTGACTATGGCAAGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34813	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				GGCTGTTTCTGCTTCTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34814	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				TCCAGGCTCCTTGATACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30780	chr11	69048056	69049412	69280589	69281945	34815	hg19	N/A	enh28849	N/A	Enhatls33461	enhancer	E_207				TTACTCAATGTCACACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	10167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5449
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34816	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34817	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34818	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34819	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34820	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34821	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34822	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34823	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34824	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34825	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34826	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34827	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CAGTCACCACATTAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34828	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34829	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34830	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34831	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34832	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34833	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34834	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34835	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34836	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34837	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34838	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34839	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				AACTAGAGTGAGAGCCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34840	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34841	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34842	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34843	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34844	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34845	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34846	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34847	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34848	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34849	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34850	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34851	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TTAAAGTTCTTAATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34852	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34853	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34854	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34855	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34856	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34857	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34858	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34859	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34860	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34861	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34862	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34863	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				ACACAAGACACGCTGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34864	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34865	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34866	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34867	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34868	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34869	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34870	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34871	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34872	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34873	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34874	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34875	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CTTTGCAGCCGAGCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34876	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34877	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34878	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34879	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34880	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34881	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34882	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34883	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34884	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34885	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34886	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34887	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TAGAAGGGGTGGTCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34888	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34889	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34890	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34891	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34892	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34893	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34894	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34895	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34896	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34897	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34898	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34899	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				AATCCATTCATTCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34900	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34901	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34902	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34903	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34904	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34905	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34906	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34907	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34908	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34909	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34910	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34911	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GAGAGGAGTCAGGGGTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34912	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34913	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34914	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34915	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34916	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34917	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34918	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34919	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34920	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34921	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34922	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34923	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TGAGCGGAAGAGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34924	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34925	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34926	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34927	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34928	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34929	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34930	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34931	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34932	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34933	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34934	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34935	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				ATGCCCAGACATTTAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34936	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34937	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34938	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34939	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34940	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34941	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34942	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34943	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34944	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34945	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34946	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34947	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CTGCTCAGCAGGCCCTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34948	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34949	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34950	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34951	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34952	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34953	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34954	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34955	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34956	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34957	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34958	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34959	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GCAGTTGCCAAGGGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34960	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34961	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34962	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34963	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34964	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34965	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34966	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34967	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34968	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34969	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34970	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34971	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GGGTGTCCACACCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34972	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34973	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34974	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34975	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34976	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34977	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34978	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34979	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34980	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34981	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34982	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34983	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GGGAGCCCTCTGACCTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34984	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34985	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34986	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34987	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34988	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34989	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34990	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34991	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34992	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34993	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	34994	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	34995	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CAGTGAATCTTAGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	34996	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34997	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34998	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	34999	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35000	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35001	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35002	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35003	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35004	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35005	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35006	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35007	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GCTGCTGAGGAGACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35008	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35009	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35010	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35011	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35012	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35013	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35014	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35015	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35016	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35017	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35018	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35019	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TGGCCTGGTCCACTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35020	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35021	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35022	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35023	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35024	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35025	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35026	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35027	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35028	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35029	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35030	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35031	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GACTACAGACGAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35032	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35033	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35034	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35035	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35036	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35037	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35038	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35039	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35040	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35041	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35042	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35043	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				AGGAGGGACAGAGGAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35044	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35045	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35046	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35047	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35048	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35049	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35050	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35051	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35052	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35053	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35054	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35055	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GCTTCAGGGGCTAAGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35056	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35057	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35058	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35059	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35060	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35061	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35062	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35063	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35064	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35065	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35066	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35067	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TCTCCCTTTCACCTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35068	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35069	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35070	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35071	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35072	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35073	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35074	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35075	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35076	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35077	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35078	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35079	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TGTCACAGCATCGAAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35080	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35081	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35082	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35083	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35084	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35085	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35086	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35087	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35088	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35089	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35090	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35091	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				AAGGTCTTAAGCTTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35092	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35093	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35094	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35095	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35096	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35097	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35098	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35099	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35100	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35101	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35102	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35103	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TACAGGGAAACCATAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35104	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35105	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35106	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35107	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35108	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35109	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35110	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35111	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35112	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35113	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35114	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35115	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CATTCTGTGGCAGCCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35116	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35117	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35118	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35119	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35120	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35121	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35122	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35123	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35124	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35125	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35126	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35127	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GGTACACTCTAAACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35128	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35129	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35130	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35131	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35132	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35133	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35134	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35135	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35136	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35137	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35138	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35139	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GCTGGGTGCAAGCCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35140	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35141	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35142	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35143	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35144	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35145	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35146	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35147	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35148	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35149	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35150	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35151	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GCTATCACCACATGGTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35152	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35153	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35154	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35155	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35156	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35157	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35158	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35159	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35160	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35161	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35162	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35163	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GATGATGTGGGGCACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35164	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35165	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35166	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35167	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35168	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35169	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35170	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35171	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35172	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35173	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35174	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35175	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GGCCACTGTGCGCTGGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35176	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35177	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35178	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35179	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35180	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35181	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35182	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35183	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35184	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35185	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35186	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35187	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GACTCAGCAGCGATTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35188	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35189	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35190	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35191	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35192	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35193	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35194	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35195	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35196	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35197	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35198	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35199	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				TCACTGGGGCTGACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35200	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35201	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35202	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35203	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35204	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35205	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35206	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35207	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35208	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35209	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35210	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35211	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GTTCCGGCCACAAAAGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35212	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35213	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35214	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35215	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35216	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35217	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35218	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35219	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35220	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35221	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35222	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35223	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				CTTAGATGTAGACATAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30781	chr11	69061065	69089755	69293598	69322287	35224	hg19	N/A	N/A	N/A	Enhatls33462	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5450
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35225	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35226	hg19	N/A	enh14032	fant39069	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	2781				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35227	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	3399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35228	hg19	N/A	enh14032	fant39070	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4426				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30782	chr11	69061065	69089755	69293598	69322287	35229	hg19	N/A	enh14032	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	4968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5451
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35230	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	9262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35231	hg19	N/A	enh28850	fant39071	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	13874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35232	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14389				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35233	hg19	N/A	enh28850	fant39072	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14770				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30783	chr11	69061065	69089755	69293598	69322287	35234	hg19	N/A	enh28850	N/A	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	14949				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5452
enhrx-30784	chr11	69061065	69089755	69293598	69322287	35235	hg19	N/A	N/A	fant39073	N/A	enhancer	E_208				GTTTCTGATGGTGGTGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	24401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5453
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35236	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				GTTTTAAAACACATATTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35237	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				GTTCATGACTTTTCATTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35238	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				CCAGTTTAGGACAACAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35239	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				GGATTTGAGTCGGGGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35240	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				CTTCTGTGAAGTGGAGATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35241	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				TGTTAAATGATTATTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35242	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				ATTAGTAAACACTCAGCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35243	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				CATGGGAATGCTTGTTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69165670	69171791	69350902	69357023	35244	hg19	N/A	enh28852	N/A	Enhatls33470	enhancer	E_209				GAGAACAGAACTGTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	45611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35245	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TAGTAGGAGTTCCTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35246	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				TAGTAGGAGTTCCTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35247	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TAGTAGGAGTTCCTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35248	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				TAGTAGGAGTTCCTTTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35249	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGACCCTCAGCGACCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35250	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				AGACCCTCAGCGACCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35251	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGACCCTCAGCGACCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35252	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				AGACCCTCAGCGACCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35253	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TTTATAGCATCTGCGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35254	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				TTTATAGCATCTGCGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35255	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TTTATAGCATCTGCGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35256	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				TTTATAGCATCTGCGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35257	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TTTTGTCTGGGGCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35258	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				TTTTGTCTGGGGCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35259	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TTTTGTCTGGGGCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35260	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				TTTTGTCTGGGGCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35261	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GAGCTGGAATTTATGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35262	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				GAGCTGGAATTTATGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35263	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GAGCTGGAATTTATGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35264	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				GAGCTGGAATTTATGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35265	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				ATCAGCTCAGCCACGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35266	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				ATCAGCTCAGCCACGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35267	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				ATCAGCTCAGCCACGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35268	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				ATCAGCTCAGCCACGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35269	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCCACAGGACAATAGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35270	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				GCCACAGGACAATAGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35271	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCCACAGGACAATAGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35272	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				GCCACAGGACAATAGTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35273	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				CCCACTGTGTGGATTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35274	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				CCCACTGTGTGGATTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35275	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				CCCACTGTGTGGATTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35276	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				CCCACTGTGTGGATTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35277	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGCCTGCTAAAATTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35278	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				AGCCTGCTAAAATTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35279	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGCCTGCTAAAATTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35280	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				AGCCTGCTAAAATTCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35281	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TCTTCTGCCTGGGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35282	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				TCTTCTGCCTGGGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35283	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				TCTTCTGCCTGGGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35284	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				TCTTCTGCCTGGGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35285	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				ACCCTGACGGAACTGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35286	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				ACCCTGACGGAACTGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35287	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				ACCCTGACGGAACTGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35288	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				ACCCTGACGGAACTGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35289	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCAGAGGACACCACACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35290	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				GCAGAGGACACCACACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35291	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCAGAGGACACCACACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35292	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				GCAGAGGACACCACACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35293	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GTGAGGCTGTGATTCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35294	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				GTGAGGCTGTGATTCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35295	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GTGAGGCTGTGATTCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35296	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				GTGAGGCTGTGATTCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35297	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGGGCTGGTTCCACAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35298	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				AGGGCTGGTTCCACAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35299	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				AGGGCTGGTTCCACAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35300	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				AGGGCTGGTTCCACAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35301	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCCTACCTGCCACGGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35302	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				GCCTACCTGCCACGGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35303	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				GCCTACCTGCCACGGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35304	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				GCCTACCTGCCACGGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35305	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				CCAGACCCTCTGTCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	110671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35306	hg19	N/A	enh14034	fant39077	Enhatls33470	enhancer	E_210				CCAGACCCTCTGTCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123335				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35307	hg19	N/A	enh14034	N/A	Enhatls33470	enhancer	E_210				CCAGACCCTCTGTCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	123522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69227712	69239554	69412944	69424786	35308	hg19	N/A	N/A	N/A	Enhatls33470	enhancer	E_210				CCAGACCCTCTGTCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	127021				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35309	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35310	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35311	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35312	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35313	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35314	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35315	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35316	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35317	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35318	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35319	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35320	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35321	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATGGTCTGTGGGGCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35322	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35323	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35324	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35325	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35326	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35327	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35328	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35329	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35330	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35331	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35332	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35333	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35334	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGCCTCATTGAGGGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35335	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35336	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35337	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35338	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35339	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35340	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35341	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35342	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35343	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35344	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35345	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35346	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35347	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGAACGTTGTTGGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35348	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35349	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35350	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35351	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35352	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35353	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35354	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35355	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35356	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35357	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35358	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35359	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35360	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CTACACCTGTCTGCCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35361	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35362	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35363	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35364	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35365	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35366	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35367	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35368	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35369	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35370	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35371	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35372	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35373	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TGGGTGGCTGACCACATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35374	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35375	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35376	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35377	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35378	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35379	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35380	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35381	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35382	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35383	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35384	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35385	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35386	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GTTGGGCGACCTGCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35387	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35388	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35389	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35390	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35391	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35392	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35393	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35394	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35395	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35396	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35397	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35398	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35399	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATTCACTGTTCATCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35400	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35401	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35402	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35403	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35404	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35405	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35406	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35407	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35408	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35409	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35410	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35411	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35412	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAGACCTTTAGAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35413	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35414	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35415	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35416	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35417	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35418	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35419	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35420	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35421	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35422	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35423	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35424	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35425	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AATGCTCATTGGGGAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35426	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35427	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35428	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35429	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35430	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35431	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35432	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35433	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35434	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35435	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35436	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35437	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35438	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCTGCATTTCCTGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35439	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35440	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35441	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35442	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35443	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35444	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35445	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35446	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35447	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35448	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35449	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35450	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35451	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CATATGCCACGTGCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35452	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35453	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35454	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35455	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35456	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35457	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35458	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35459	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35460	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35461	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35462	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35463	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35464	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GAACTTCGCCTGCAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35465	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35466	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35467	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35468	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35469	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35470	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35471	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35472	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35473	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35474	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35475	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35476	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35477	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCCGGGCTGATTCCAGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35478	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35479	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35480	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35481	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35482	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35483	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35484	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35485	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35486	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35487	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35488	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35489	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35490	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				AGCTCCTGACAATAGCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35491	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35492	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35493	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35494	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35495	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35496	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35497	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35498	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35499	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35500	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35501	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35502	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35503	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGAACCCTGAACAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35504	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35505	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35506	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35507	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35508	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35509	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35510	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35511	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35512	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35513	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35514	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35515	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35516	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CGCCTGGTCTCCGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35517	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35518	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35519	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35520	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35521	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35522	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35523	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35524	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35525	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35526	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35527	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35528	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35529	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GGCCATTCATGAAAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35530	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35531	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35532	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35533	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35534	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35535	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35536	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35537	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35538	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35539	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35540	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35541	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35542	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGCAGCATGGCCCGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35543	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35544	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35545	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35546	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35547	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35548	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35549	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35550	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35551	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35552	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35553	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35554	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35555	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCACAGTTGACCGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35556	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35557	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35558	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35559	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35560	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35561	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35562	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35563	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35564	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35565	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35566	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35567	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35568	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCTGGACACAGGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35569	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35570	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35571	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35572	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35573	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35574	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35575	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35576	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35577	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35578	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35579	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35580	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35581	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				TCCAAGGCGGACGGAGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35582	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35583	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35584	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35585	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35586	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35587	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35588	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35589	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35590	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35591	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35592	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35593	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35594	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				GCCCCGGTGACACTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35595	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35596	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35597	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35598	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35599	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35600	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35601	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35602	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35603	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35604	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35605	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35606	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35607	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCTGGCTTTCACTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35608	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35609	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35610	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35611	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35612	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35613	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35614	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35615	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35616	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35617	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35618	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35619	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35620	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				ATCCTGCATGTTTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35621	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35622	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35623	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35624	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35625	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35626	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35627	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35628	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35629	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35630	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35631	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35632	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35633	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAGCAGGTGTGCATCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35634	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35635	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35636	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35637	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35638	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35639	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35640	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35641	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35642	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35643	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35644	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35645	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35646	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CCGGGTCCACTGCCTGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35647	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	128211				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35648	hg19	N/A	enh14035	fant39078	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138154				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35649	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	138286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35650	hg19	N/A	enh14035	fant39079	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	139888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35651	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	140187				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35652	hg19	N/A	enh14035	fant39080	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	144950				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35653	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145083				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35654	hg19	N/A	enh14035	fant39081	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35655	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	145840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35656	hg19	N/A	enh14035	fant39082	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146040				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35657	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	146403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35658	hg19	N/A	enh14035	fant39083	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30786	chr11	69240490	69267040	69425722	69452272	35659	hg19	N/A	enh14035	N/A	Enhatls33470	enhancer	E_211				CAAGCGCCAGGGAAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					MYEOV	chr11	69294154	69297287	152730				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5455
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35660	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				AGGCAACGTGGCACAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35661	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				TGAGACCTCAACCTGTAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35662	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				CCTCATTCTGCAGACCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35663	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				TTTTGACTTTGGGCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35664	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				TGAAACATCAGATAAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35665	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				GATGCAGCTTCCAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35666	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				AGCTACAGCAAACTACATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35667	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				TTCCCTCAAATAACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35668	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				TGGTATGTTTCCCCATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35669	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				AGCTTGCTGGAACTGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35670	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				ACTGCAGATGATTCAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35671	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				GTACCTAAGTTCACTCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30788	chr11	69402170	69403969	69587402	69589201	35672	hg19	N/A	enh28855	N/A	Enhatls33476	enhancer	E_213				GCCTAGGATTATGGACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					CCND1	chr11	69641155	69654474	50437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5457
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35673	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				AAAAAAAAAAAATTAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35674	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				CTTGAGTTGTTTCCACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35675	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				TTTGTACCTGAGTTGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35676	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				TTTTATCAGACTACTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35677	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				GGCAGGCAATGAGGATATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35678	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				TATCTGACTCTGTTATGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	direct	Highly Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35679	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				GTATCCCCCATAGGTAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35680	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				ATTTTTAAGTTTCATCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30808	chr11	69669026	69669992	69854258	69855224	35681	hg19	N/A	enh79916	N/A	Enhatls33497	enhancer	E_214				ATGATGCTGGCCGGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					FGF3	chr11	69809967	69819416	31262				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5477
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35682	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TCTTCCTGCACAATCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35683	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TCTTCCTGCACAATCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35684	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TGTGGGGCTCACCCTTAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35685	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TGTGGGGCTCACCCTTAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35686	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				GGGAATCTGCTATCGATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35687	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				GGGAATCTGCTATCGATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35688	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				CTTGGTAGAAGAGTTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35689	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				CTTGGTAGAAGAGTTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35690	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TCTAGAATCCAGGCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35691	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TCTAGAATCCAGGCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35692	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				AGACACACCTTGGCCCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35693	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				AGACACACCTTGGCCCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35694	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TAGGGCGTCTGGCCTTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35695	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TAGGGCGTCTGGCCTTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35696	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TTCTTTTTCCCCTACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35697	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TTCTTTTTCCCCTACCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35698	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TCAAAATGGGAAACACGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35699	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TCAAAATGGGAAACACGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35700	hg19	N/A	N/A	N/A	Enhatls33500	enhancer	E_215				TATTTTTTTCACTTAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-30810	chr11	69860485	69869084	70014379	70022978	35701	hg19	N/A	enh28860	N/A	Enhatls33500	enhancer	E_215				TATTTTTTTCACTTAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCND1	indirect	Non Significant	NA					ANO1	chr11	69985906	70189530	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5479
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35702	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				GGAATAACTATCCTATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35703	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				GGAATAACTATCCTATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35704	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				TATGTTGGTAACTTCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35705	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				TATGTTGGTAACTTCGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35706	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				AAGGGCATGAAGGTCACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35707	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				AAGGGCATGAAGGTCACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35708	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				ATGCAATTGGGGGCTGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35709	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				ATGCAATTGGGGGCTGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35710	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				TATCGCTTTCGAAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35711	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				TATCGCTTTCGAAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35712	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				AGGAATTGCTCAAGTTATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35713	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				AGGAATTGCTCAAGTTATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35714	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				GAAATTGCACTAAGTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35715	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				GAAATTGCACTAAGTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35716	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				GAATATGAGTGTGTTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35717	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				GAATATGAGTGTGTTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35718	hg19	N/A	enh29053	N/A	Enhatls35247	enhancer	E_218				AGTGTAAGATGAGGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	20410				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32463	chr11	101740607	101742843	101869876	101872112	35719	hg19	N/A	N/A	N/A	Enhatls35247	enhancer	E_218				AGTGTAAGATGAGGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					ANGPTL5	chr11	101890673	101916522	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7132
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35720	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				ATACTGGGGCTGGAGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35721	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				ATACTGGGGCTGGAGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35722	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				TGTTTAGTCCAGGCTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35723	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				TGTTTAGTCCAGGCTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35724	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				AATTGTACAATGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35725	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				AATTGTACAATGGCCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35726	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				ATTCTGTTGTAGATTAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35727	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				ATTCTGTTGTAGATTAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35728	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				TTCTCAACTTAATTGAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35729	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				TTCTCAACTTAATTGAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35730	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				TCAAGTTATGTACGTGTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35731	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				TCAAGTTATGTACGTGTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35732	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				GGATGATTGTTATATTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35733	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				GGATGATTGTTATATTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35734	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				AGGAGCACTGCTTCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35735	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				AGGAGCACTGCTTCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35736	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				GCATATATGTCTTTCTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35737	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				GCATATATGTCTTTCTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35738	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				CACTGTTTAAAATCAACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35739	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				CACTGTTTAAAATCAACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35740	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				GCTAATCATGTTACTCATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35741	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				GCTAATCATGTTACTCATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35742	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				GTTGTATTGGGTCTATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35743	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				GTTGTATTGGGTCTATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35744	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				ATGGGGGCTTGAATGACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35745	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				ATGGGGGCTTGAATGACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35746	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				GCAACTGATAAACACTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35747	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				GCAACTGATAAACACTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35748	hg19	N/A	N/A	N/A	Enhatls35277	enhancer	E_219				TCTAAACCCGCTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32490	chr11	102006654	102010869	102135923	102140138	35749	hg19	N/A	enh14231	N/A	Enhatls35277	enhancer	E_219				TCTAAACCCGCTTTGTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7159
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35750	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				TCTGGAGAGCTCAACTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35751	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				AAAGAAAAGTTAGCTTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35752	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				ACTTAACAACCCTACGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35753	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				AACTGTTCTTACTATGTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35754	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				TGATGAGTCCTACAAAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	indirect	Non Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35755	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				TTAACTACACCACGAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35756	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				GAGGGTCCTTAGGCAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35757	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				TTTAAAATATCACAGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35758	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				ATTAGAACTACTTAAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32491	chr11	102046271	102050616	102175540	102179885	35759	hg19	N/A	enh14232	N/A	Enhatls35278	enhancer	E_220				ACACAAAATTAGATTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7160
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35760	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35761	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35762	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35763	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35764	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35765	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				TACTAATGAATCATATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35766	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35767	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35768	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35769	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35770	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35771	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				AGAGGCTCACAACTTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35772	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35773	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35774	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35775	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35776	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35777	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				TGCAGAACCCCACTTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35778	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35779	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35780	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35781	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35782	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35783	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				GAGTTCATTCCAAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35784	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35785	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35786	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35787	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35788	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35789	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				ATAGAGTGATGACTAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35790	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35791	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35792	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35793	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35794	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35795	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				TTGTATACCAATGGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35796	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35797	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35798	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35799	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35800	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35801	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				GATGGCAGTATATAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35802	hg19	N/A	enh29054	N/A	Enhatls35281	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35803	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35804	hg19	N/A	enh29054	N/A	Enhatls35282	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35805	hg19	N/A	enh29054	N/A	N/A	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35806	hg19	N/A	enh29054	N/A	Enhatls35283	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32493	chr11	102091254	102102356	102220523	102231625	35807	hg19	N/A	N/A	N/A	Enhatls35283	enhancer	E_221				CATCATTTAGGGAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7162
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35808	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				AGCTTAGCTGCTATTAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35809	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				TTAAGAGCTTAATGTATGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35810	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				GGAACATGCTTATTCATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35811	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				ATGCTCATTGTCAAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35812	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				CAGGTGGAGCCCACACATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35813	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				ATTTGGCTTTAACTGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35814	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				CGAGCGGCAGTGACACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35815	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				AAGTGAGGGAGGGTCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35816	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				TAAACGTTTCAGCTGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35817	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				ACCCCCGTGAAGCCAGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35818	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				CCAGGGCAACTGACTCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35819	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				AGGATTATACAGAACTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102113257	102117275	102242526	102246544	35820	hg19	N/A	enh14233	N/A	Enhatls35284	enhancer	E_222				GCACTTGCAATACTAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	2951				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35821	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_223				CGTCAAAAGCAGTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	14056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35822	hg19	N/A	enh14234	N/A	Enhatls35284	enhancer	E_223				CGTCAAAAGCAGTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	17671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35823	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_223				AATGGAAAGCGAGAAATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	14056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35824	hg19	N/A	enh14234	N/A	Enhatls35284	enhancer	E_223				AATGGAAAGCGAGAAATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	17671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35825	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_223				TGACTCCTGACCATCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	14056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35826	hg19	N/A	enh14234	N/A	Enhatls35284	enhancer	E_223				TGACTCCTGACCATCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	17671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35827	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_223				TGTTAAGTGGAAGTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	14056				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102121158	102129261	102250427	102258530	35828	hg19	N/A	enh14234	N/A	Enhatls35284	enhancer	E_223				TGTTAAGTGGAAGTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	17671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35829	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				CGTTGGGGTCCAAAATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35830	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				GCGGGTCAGTTTCAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35831	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				ATGTTTTCCTCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35832	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				GCTGCAATTCGAGCAAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35833	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				AGTCATTGTTTACAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35834	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				TTGCCTGTCATTAAAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35835	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				CGGCCTGACTGACTTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35836	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				CGTGGCAAACGAGAATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35837	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				CCCCGGTGGAGAAAGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35838	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				ACGAACACCTGCCTGTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35839	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				AGTCATCCCCGGCAATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102138081	102139658	102267350	102268927	35840	hg19	N/A	enh14235	N/A	Enhatls35284	enhancer	E_224				AGAGTCCAGTCACTTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					YAP1	chr11	102110446	102233424	32271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35841	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				TTTACGTGTAAAGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35842	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				TTTACGTGTAAAGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35843	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				TTTACGTGTAAAGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35844	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				TTTACGTGTAAAGTGTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35845	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				TGATAACAACCCATATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35846	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				TGATAACAACCCATATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35847	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				TGATAACAACCCATATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35848	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				TGATAACAACCCATATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35849	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				AAAAGCATGACTCTTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35850	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				AAAAGCATGACTCTTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35851	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				AAAAGCATGACTCTTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35852	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				AAAAGCATGACTCTTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35853	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				GCGTTCCGCACTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35854	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				GCGTTCCGCACTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35855	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				GCGTTCCGCACTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35856	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				GCGTTCCGCACTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35857	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				CTGGCCTTTTCCGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35858	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				CTGGCCTTTTCCGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35859	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				CTGGCCTTTTCCGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35860	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				CTGGCCTTTTCCGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35861	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				CAGGTGTCGCTTGAAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35862	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				CAGGTGTCGCTTGAAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35863	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				CAGGTGTCGCTTGAAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35864	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				CAGGTGTCGCTTGAAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35865	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				GTCGTCGGCCTCTGGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35866	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				GTCGTCGGCCTCTGGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35867	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				GTCGTCGGCCTCTGGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35868	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				GTCGTCGGCCTCTGGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35869	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				GATGTGCCAGCGGCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35870	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				GATGTGCCAGCGGCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35871	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				GATGTGCCAGCGGCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35872	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				GATGTGCCAGCGGCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35873	hg19	N/A	enh14236	N/A	Enhatls35284	enhancer	E_225				GGCGCAGTTATCAAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5620				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32494	chr11	102181614	102189520	102310883	102318789	35874	hg19	N/A	N/A	N/A	Enhatls35284	enhancer	E_225				GGCGCAGTTATCAAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	5035				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7163
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35875	hg19	N/A	N/A	N/A	Enhatls35285	enhancer	E_225				GGCGCAGTTATCAAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32495	chr11	102181614	102189520	102310883	102318789	35876	hg19	N/A	N/A	fant39709	Enhatls35285	enhancer	E_225				GGCGCAGTTATCAAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					BIRC3	chr11	102317483	102339403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7164
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35877	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				TGTCCATTTCACAAAGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35878	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				GAAAGACCTAAGTTTGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35879	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				AGGCTAAATGGAAGAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35880	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				GCTGTTAGGAAAGCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35881	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				GAGTCATCACTGAGATTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35882	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				GTACTCCCTTGAGGATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35883	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				AGTCTCTCTAAAGCACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35884	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				AGAGCTTTCTTCTTAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32519	chr11	102443765	102445446	102573034	102574715	35885	hg19	N/A	enh111825	N/A	Enhatls35308	enhancer	E_226				CACTTGAGCCCAGGGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	708				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7188
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35886	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35887	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35888	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35889	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35890	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35891	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35892	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35893	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35894	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35895	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35896	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TCCAGTGAAGCAAACTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35897	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35898	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35899	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35900	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35901	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35902	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35903	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35904	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35905	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35906	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35907	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TCTATGGGACTCATTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35908	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35909	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35910	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35911	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35912	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35913	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35914	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35915	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35916	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35917	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35918	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TCAGTGAGGTGGATGATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35919	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35920	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35921	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35922	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35923	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35924	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35925	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35926	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35927	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35928	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35929	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				CCACAGCACTGGCTACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35930	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35931	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35932	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35933	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35934	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35935	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35936	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35937	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35938	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35939	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35940	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				ATAACCTGTGAACATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35941	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35942	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35943	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35944	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35945	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35946	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35947	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35948	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35949	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35950	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35951	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GAAGAAATGACAATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35952	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35953	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35954	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35955	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35956	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35957	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35958	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35959	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35960	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35961	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35962	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GTAAACACAATGCCATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35963	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35964	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35965	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35966	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35967	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35968	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35969	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35970	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35971	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35972	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35973	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GTTAGCTATAATAAGTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35974	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35975	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35976	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35977	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35978	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35979	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35980	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35981	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35982	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35983	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35984	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GGTTTGTTTCCAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35985	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35986	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35987	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35988	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35989	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35990	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35991	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35992	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35993	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35994	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	35995	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TGTTGGTGACGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35996	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	35997	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	35998	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	35999	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36000	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36001	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36002	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36003	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36004	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36005	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36006	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GGGAGCGCTTTCATAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36007	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36008	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36009	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36010	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36011	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36012	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36013	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36014	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36015	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36016	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36017	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				CTTTTAGCGGCAGCTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36018	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36019	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36020	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36021	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36022	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36023	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36024	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36025	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36026	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36027	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36028	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GCTCTGGACAGCACCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36029	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36030	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36031	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36032	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36033	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36034	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36035	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36036	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36037	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36038	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36039	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TGTAAAAGGAATAATACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36040	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36041	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36042	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36043	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36044	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36045	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36046	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36047	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36048	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36049	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36050	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GACTTGCCACTAACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36051	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36052	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36053	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36054	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36055	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36056	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36057	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36058	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36059	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36060	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36061	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				TCAGATTCAATGAGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36062	hg19	N/A	enh14239	N/A	Enhatls35312	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32523	chr11	102467226	102482531	102596495	102611800	36063	hg19	N/A	N/A	N/A	Enhatls35312	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7192
enhrx-32524	chr11	102467226	102482531	102596495	102611800	36064	hg19	N/A	N/A	N/A	Enhatls35313	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7193
enhrx-32525	chr11	102467226	102482531	102596495	102611800	36065	hg19	N/A	N/A	N/A	Enhatls35314	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7194
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36066	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36067	hg19	N/A	N/A	fant39723	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36068	hg19	N/A	N/A	N/A	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36069	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36070	hg19	N/A	enh57588	fant39724	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36071	hg19	N/A	enh57588	N/A	Enhatls35315	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-32526	chr11	102467226	102482531	102596495	102611800	36072	hg19	N/A	enh57588	N/A	N/A	enhancer	E_227				GCAGATACGTACATTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	YAP1	direct	Highly Significant	NA					MMP20	chr11	102576831	102625332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7195
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36073	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36074	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36075	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36076	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36077	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36078	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ATGGAGAAGCGTCATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36079	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36080	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36081	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36082	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36083	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36084	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TATAAGGCAGAGCCTGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36085	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36086	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36087	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36088	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36089	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36090	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GTCCAGCAATAGAAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36091	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36092	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36093	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36094	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36095	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36096	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACTGCTCATCCTGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36097	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36098	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36099	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36100	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36101	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36102	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACGTCTCTGAGCAGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36103	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36104	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36105	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36106	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36107	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36108	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAGGTATTGAGTGCTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36109	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36110	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36111	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36112	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36113	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36114	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACAAGTGTGACGAGGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36115	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36116	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36117	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36118	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36119	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36120	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAGCAACCAAGAACAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36121	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36122	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36123	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36124	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36125	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36126	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CCTGCATTCCAGAAACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36127	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36128	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36129	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36130	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36131	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36132	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TGTGTAAGCCCCCTAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36133	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36134	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36135	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36136	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36137	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36138	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				AGCAAACCCCTAGATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36139	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36140	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36141	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36142	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36143	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36144	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GCCGTGACCGAGACAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36145	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36146	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36147	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36148	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36149	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36150	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				CGGGCTGGGGAAGCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36151	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36152	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36153	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36154	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36155	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36156	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GAATTCAGGCCGATGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36157	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36158	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36159	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36160	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36161	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36162	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				ACACACCGAGTGGTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36163	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36164	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36165	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36166	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36167	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36168	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TAAGTGGGCACGGTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36169	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36170	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36171	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36172	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36173	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36174	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GATGGAGGAGTGACTTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36175	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36176	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36177	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36178	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36179	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36180	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				TTTGCTGCTGTTGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36181	hg19	N/A	N/A	N/A	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	22616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36182	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36183	hg19	N/A	enh14490	fant40778	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	20101				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36184	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17523				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36185	hg19	N/A	enh14490	fant40779	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	17125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35202	chr12	6286139	6293694	6176973	6184528	36186	hg19	N/A	enh14490	N/A	Enhatls38204	enhancer	E_230				GGAGGCTCCCATTCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD9	chr12	6199714	6238271	13646				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	512
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36187	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AGATCTCCCCTGTCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36188	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				AGATCTCCCCTGTCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36189	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AGATCTCCCCTGTCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36190	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GGCACCCCTGTGATTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36191	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				GGCACCCCTGTGATTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36192	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GGCACCCCTGTGATTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36193	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TTGCTGTGGGGGAGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36194	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TTGCTGTGGGGGAGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36195	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TTGCTGTGGGGGAGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36196	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GTGCACTCTTCCCATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36197	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				GTGCACTCTTCCCATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36198	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GTGCACTCTTCCCATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36199	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AGTTTGCTAATACGAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36200	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				AGTTTGCTAATACGAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36201	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AGTTTGCTAATACGAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36202	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGGCGAGTTGCCCTCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36203	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TGGCGAGTTGCCCTCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36204	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGGCGAGTTGCCCTCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36205	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GTCTCTCTAGAATAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36206	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				GTCTCTCTAGAATAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36207	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				GTCTCTCTAGAATAAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36208	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TCGTTTCGTTAAATAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36209	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TCGTTTCGTTAAATAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36210	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TCGTTTCGTTAAATAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36211	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AAGCACGAAAAGCAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36212	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				AAGCACGAAAAGCAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36213	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AAGCACGAAAAGCAAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36214	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGCCAGGCACAATTGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36215	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TGCCAGGCACAATTGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36216	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGCCAGGCACAATTGTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36217	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AAAGCAATATAAGAAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36218	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				AAAGCAATATAAGAAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36219	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AAAGCAATATAAGAAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36220	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGGGGTGGAAGGATTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36221	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TGGGGTGGAAGGATTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36222	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TGGGGTGGAAGGATTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36223	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TCCAGAGTATCTAGGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36224	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				TCCAGAGTATCTAGGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36225	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				TCCAGAGTATCTAGGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36226	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				CCAGCCTGGGTGAGTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36227	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				CCAGCCTGGGTGAGTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36228	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				CCAGCCTGGGTGAGTAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36229	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AACATGGAACTGCCAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14555				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36230	hg19	N/A	enh2158	fant40799	Enhatls38255	enhancer	E_232				AACATGGAACTGCCAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	14092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35242	chr12	6536913	6543582	6427747	6434416	36231	hg19	N/A	enh2158	N/A	Enhatls38255	enhancer	E_232				AACATGGAACTGCCAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					CD27	chr12	6444954	6451713	6126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	552
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36232	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TGAGAACAGGGGACGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36233	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TGAGAACAGGGGACGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36234	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GTCTGTGTAAACTCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36235	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GTCTGTGTAAACTCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36236	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GGCTGTTCTGCAGATTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36237	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GGCTGTTCTGCAGATTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36238	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GGCTGCCGGTAAATGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36239	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GGCTGCCGGTAAATGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36240	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TCACCCAGCTTCAAGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36241	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TCACCCAGCTTCAAGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36242	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TTGGCAGATGAGGGGGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36243	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TTGGCAGATGAGGGGGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36244	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				ATGTTTGTCCTTTCCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36245	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				ATGTTTGTCCTTTCCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36246	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GAGCTGGTAACGTACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36247	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GAGCTGGTAACGTACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36248	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GTGGAGAGGGATTAAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36249	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GTGGAGAGGGATTAAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36250	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				CTAGGGGTTATTTGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36251	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				CTAGGGGTTATTTGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36252	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GAGAAAAGCCCTAACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36253	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GAGAAAAGCCCTAACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36254	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				ATTAGCCAGCCCCATTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36255	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				ATTAGCCAGCCCCATTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36256	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TTAGGTCACAATGCGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36257	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TTAGGTCACAATGCGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36258	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GGAGCGCTCGAAAAGGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36259	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GGAGCGCTCGAAAAGGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36260	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GGAAGCTGTCTGAAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36261	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GGAAGCTGTCTGAAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36262	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GGCGGGGCTCAGGCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36263	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GGCGGGGCTCAGGCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36264	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TCGGGGTCAGGCGCTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36265	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TCGGGGTCAGGCGCTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36266	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GACCCGCGAGGCCACCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36267	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GACCCGCGAGGCCACCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36268	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				GCTCCGGTGACTTAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36269	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				GCTCCGGTGACTTAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36270	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				TGGTTGTTGAAGCGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36271	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				TGGTTGTTGAAGCGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-35479	chr12	7340661	7343541	7188065	7190945	36272	hg19	N/A	N/A	N/A	Enhatls38518	enhancer	E_235				AGTCGCGGAGGCCTCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	789
enhrx-35480	chr12	7340661	7343541	7188065	7190945	36273	hg19	N/A	N/A	N/A	Enhatls38519	enhancer	E_235				AGTCGCGGAGGCCTCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TPI1,LPAR5,PLEKHG6"	direct	Highly Significant	NA					PEX5	chr12	7188684	7218571	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	790
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36274	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TGTCTTTTTGCAGCCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36275	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TGTCTTTTTGCAGCCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36276	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				TGTCTTTTTGCAGCCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36277	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TGTCTTTTTGCAGCCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36278	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TGTCTTTTTGCAGCCTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36279	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				CAGCTGGTAAGTGCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36280	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				CAGCTGGTAAGTGCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36281	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				CAGCTGGTAAGTGCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36282	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				CAGCTGGTAAGTGCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36283	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				CAGCTGGTAAGTGCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36284	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ACTGTAACCTAACTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36285	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ACTGTAACCTAACTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36286	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				ACTGTAACCTAACTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36287	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ACTGTAACCTAACTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36288	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ACTGTAACCTAACTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36289	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TTGAATTGAGAAGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36290	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TTGAATTGAGAAGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36291	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				TTGAATTGAGAAGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36292	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TTGAATTGAGAAGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36293	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TTGAATTGAGAAGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36294	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TGAATGTTATAAGAAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36295	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TGAATGTTATAAGAAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36296	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				TGAATGTTATAAGAAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36297	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TGAATGTTATAAGAAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36298	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TGAATGTTATAAGAAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36299	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				AATATCAAGAGAGTATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36300	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				AATATCAAGAGAGTATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36301	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				AATATCAAGAGAGTATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36302	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				AATATCAAGAGAGTATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36303	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				AATATCAAGAGAGTATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36304	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TACTTGGACTGTGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36305	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TACTTGGACTGTGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36306	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				TACTTGGACTGTGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36307	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				TACTTGGACTGTGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36308	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				TACTTGGACTGTGAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36309	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ACAATAGCAGCGTCTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36310	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ACAATAGCAGCGTCTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36311	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				ACAATAGCAGCGTCTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36312	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ACAATAGCAGCGTCTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36313	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ACAATAGCAGCGTCTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36314	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ATTCAGTCTATTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	48655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36315	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ATTCAGTCTATTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	51485				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36316	hg19	N/A	enh29447	fant41226	Enhatls39774	enhancer	E_236				ATTCAGTCTATTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36317	hg19	N/A	enh29447	N/A	Enhatls39774	enhancer	E_236				ATTCAGTCTATTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55437				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24764980	24772896	24612046	24619962	36318	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_236				ATTCAGTCTATTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					SOX5	chr12	23529503	24562487	55635				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36319	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				GTGTGAAAAATATTCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36320	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				GTGTGAAAAATATTCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36321	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				AGGAGAAAACAGGGATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36322	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				AGGAGAAAACAGGGATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36323	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				TATTTGATGATACAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36324	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				TATTTGATGATACAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36325	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				AGAAAATTGGGCTAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36326	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				AGAAAATTGGGCTAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36327	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				TTACATACATGATTAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36328	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				TTACATACATGATTAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36329	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				AAGGGTGGTGTGTGCCTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36330	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				AAGGGTGGTGTGTGCCTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36331	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				GTCTTGCTTGTGAGGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36332	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				GTCTTGCTTGTGAGGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36333	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				CAGGGACCATTACATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36334	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				CAGGGACCATTACATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36335	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				CCTGGGTGTGAAGGCTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36336	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				CCTGGGTGTGAAGGCTTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36337	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				TGGGGTCTCCCATTGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36338	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				TGGGGTCTCCCATTGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36339	hg19	N/A	N/A	N/A	Enhatls39774	enhancer	E_237				TCACTGTTACATCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	92623				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36690	chr12	24870075	24874177	24717141	24721243	36340	hg19	N/A	enh29448	N/A	Enhatls39774	enhancer	E_237				TCACTGTTACATCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	88762				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2000
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36341	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36342	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36343	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36344	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36345	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36346	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAGGTCCGGTTTGGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36347	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36348	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36349	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36350	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36351	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36352	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AAACAGCACTTGCACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36353	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36354	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36355	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36356	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36357	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36358	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GAACTGTAACCACTAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36359	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36360	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36361	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36362	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36363	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36364	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTCCAGATTGCCCAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36365	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36366	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36367	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36368	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36369	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36370	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TTTCCATTAGTGTTTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36371	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36372	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36373	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36374	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36375	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36376	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAATTGTGCTGATGGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36377	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36378	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36379	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36380	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36381	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36382	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GTGTCTATTAGAAAGTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36383	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36384	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36385	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36386	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36387	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36388	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TAGTATGTTAGACTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36389	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36390	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36391	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36392	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36393	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36394	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ATTTGTAAGCAAAGATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36395	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36396	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36397	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36398	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36399	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36400	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				GCGTGTATACGGACTCGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36401	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36402	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36403	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36404	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36405	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36406	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				TGACTGTGAACTCAACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36407	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36408	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36409	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36410	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36411	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36412	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				AATGGTGAATAGCAAGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	indirect	Non Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36413	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36414	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36415	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36416	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36417	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36418	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				CTGTGCACAGTCACTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36419	hg19	N/A	enh14575	fant41245	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36420	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36421	hg19	N/A	enh14575	fant41246	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36422	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36423	hg19	N/A	enh14575	fant41247	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36693	chr12	24990994	24994415	24838060	24841481	36424	hg19	N/A	enh14575	N/A	Enhatls39778	enhancer	E_239				ACTGCTCCTGTTGGTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2003
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36425	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				TTTTCACTGTTAAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36426	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				TTTTCACTGTTAAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36427	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				TTTTCACTGTTAAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36428	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				TTTTCACTGTTAAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36429	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GTTCGTGATGCAGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36430	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				GTTCGTGATGCAGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36431	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GTTCGTGATGCAGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36432	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				GTTCGTGATGCAGGAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36433	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GGAATTTTGGAGAGGAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36434	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				GGAATTTTGGAGAGGAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36435	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GGAATTTTGGAGAGGAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36436	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				GGAATTTTGGAGAGGAGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36437	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				CCAAACTTCACAAGCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36438	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				CCAAACTTCACAAGCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36439	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				CCAAACTTCACAAGCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36440	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				CCAAACTTCACAAGCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36441	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GAGAAGGCACGTCCTGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36442	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				GAGAAGGCACGTCCTGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36443	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GAGAAGGCACGTCCTGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36444	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				GAGAAGGCACGTCCTGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36445	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				AGATACTGAGACGTTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36446	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				AGATACTGAGACGTTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36447	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				AGATACTGAGACGTTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36448	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				AGATACTGAGACGTTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36449	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ATGTTTCTTGGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36450	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				ATGTTTCTTGGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36451	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ATGTTTCTTGGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36452	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				ATGTTTCTTGGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36453	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				AGCCGCAGACCCGGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36454	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				AGCCGCAGACCCGGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36455	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				AGCCGCAGACCCGGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36456	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				AGCCGCAGACCCGGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36457	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				CGTGTACTCGCCGCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36458	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				CGTGTACTCGCCGCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36459	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				CGTGTACTCGCCGCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36460	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				CGTGTACTCGCCGCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36461	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GGAGAGACTCCACCATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36462	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				GGAGAGACTCCACCATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36463	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				GGAGAGACTCCACCATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36464	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				GGAGAGACTCCACCATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36465	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				TCACTCACTGCTCACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36466	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				TCACTCACTGCTCACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36467	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				TCACTCACTGCTCACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36468	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				TCACTCACTGCTCACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36469	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ACTCGGATACGCACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36470	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				ACTCGGATACGCACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36471	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ACTCGGATACGCACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36472	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				ACTCGGATACGCACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36473	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ATATGGAGACGTCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36474	hg19	N/A	N/A	fant41255	Enhatls39785	enhancer	E_240				ATATGGAGACGTCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36700	chr12	25098788	25104090	24945854	24951156	36475	hg19	N/A	N/A	N/A	Enhatls39785	enhancer	E_240				ATATGGAGACGTCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2010
enhrx-36701	chr12	25098788	25104090	24945854	24951156	36476	hg19	N/A	N/A	fant41256	N/A	enhancer	E_240				ATATGGAGACGTCAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KRAS	direct	Highly Significant	NA					BCAT1	chr12	24810023	24949101	1427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36477	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36478	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36479	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36480	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36481	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36482	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36483	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36484	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36485	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36486	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36487	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GTCTCATCAGTCCTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36488	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36489	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36490	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36491	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36492	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36493	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36494	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36495	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36496	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36497	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36498	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				ACTTTGCGTGGGCCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36499	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36500	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36501	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36502	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36503	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36504	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36505	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36506	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36507	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36508	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36509	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				CACCGTGTCTGCGGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36510	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36511	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36512	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36513	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36514	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36515	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36516	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36517	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36518	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36519	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36520	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				ATAAGGTGAGAACCAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36521	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36522	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36523	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36524	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36525	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36526	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36527	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36528	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36529	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36530	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36531	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GGGGAGGCTGGCAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36532	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36533	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36534	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36535	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36536	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36537	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36538	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36539	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36540	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36541	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36542	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GTTTACAGAATGTCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36543	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36544	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36545	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36546	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36547	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36548	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36549	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36550	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36551	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36552	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36553	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GTCCTGCTCTAAGACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36554	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36555	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36556	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36557	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36558	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36559	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36560	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36561	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36562	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36563	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36564	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GTTTCACCATCAGAAAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36565	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36566	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36567	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36568	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36569	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36570	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36571	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36572	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36573	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36574	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36575	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				GATCTTTCAATAGCCCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36576	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36577	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36578	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36579	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36580	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36581	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36582	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36583	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36584	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36585	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36586	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				CTTCCTTTTGGAATAACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36587	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36588	hg19	N/A	enh2339	fant41674	Enhatls41302	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36589	hg19	N/A	enh2339	N/A	Enhatls41302	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38149	chr12	50275876	50289805	49882093	49896022	36590	hg19	N/A	N/A	N/A	Enhatls41302	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3459
enhrx-38150	chr12	50275876	50289805	49882093	49896022	36591	hg19	N/A	N/A	N/A	Enhatls41303	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3460
enhrx-38151	chr12	50275876	50289805	49882093	49896022	36592	hg19	N/A	N/A	N/A	Enhatls41304	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3461
enhrx-38152	chr12	50275876	50289805	49882093	49896022	36593	hg19	N/A	N/A	N/A	Enhatls41305	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3462
enhrx-38153	chr12	50275876	50289805	49882093	49896022	36594	hg19	N/A	N/A	N/A	Enhatls41306	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3463
enhrx-38154	chr12	50275876	50289805	49882093	49896022	36595	hg19	N/A	N/A	N/A	Enhatls41307	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3464
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36596	hg19	N/A	N/A	N/A	Enhatls41308	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38155	chr12	50275876	50289805	49882093	49896022	36597	hg19	N/A	enh2340	N/A	Enhatls41308	enhancer	E_251				CCTCGTGTCTGAGTCCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAIM2	chr12	49866895	49904217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3465
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36598	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				AGGATATTCTAGAGTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36599	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				AAGTAGATGGTAATCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36600	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				CTCCCACACACACCACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36601	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				TCTTCTTTCACTATGTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36602	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				GATATTTTACACAAATTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36603	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				GGAAGGGTTAAGGCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36604	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				CACTATTACTGCCTTTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36605	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				CACAGTGGGAGGTTTTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36606	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				ACAGCTGGCAGGGTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36607	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				GGTTGTCCCGTACACAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-38219	chr12	50578587	50582822	50184804	50189039	36608	hg19	N/A	enh2344	N/A	Enhatls41376	enhancer	E_253				CATCCCCTAAACGTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3529
enhrx-lit685	chr12	50594775	50597159	50200992	50203376	36609	hg19					enhancer	E_254				CTACATTATTAGCAGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit686	chr12	50594775	50597159	50200992	50203376	36610	hg19					enhancer	E_254				TCTCTGTGAATCTTTAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit687	chr12	50594775	50597159	50200992	50203376	36611	hg19					enhancer	E_254				ATTACGACCCACAGCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit688	chr12	50594775	50597159	50200992	50203376	36612	hg19					enhancer	E_254				GGGGTCAGGAATGAGTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit689	chr12	50594775	50597159	50200992	50203376	36613	hg19					enhancer	E_254				TTACAACCATATTCTGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit690	chr12	50594775	50597159	50200992	50203376	36614	hg19					enhancer	E_254				TTAAGAGTTGAAAACTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit691	chr12	50594775	50597159	50200992	50203376	36615	hg19					enhancer	E_254				ACTGTAATGCAGAAATGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit692	chr12	50594775	50597159	50200992	50203376	36616	hg19					enhancer	E_254				GTGGGAATGTTTACAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36617	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GCAAATGCTAGCCAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36618	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				GCAAATGCTAGCCAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36619	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GCAAATGCTAGCCAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36620	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				GCAAATGCTAGCCAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36621	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GCAGAACCTAACCTTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36622	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				GCAGAACCTAACCTTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36623	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GCAGAACCTAACCTTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36624	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				GCAGAACCTAACCTTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36625	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				AGATCCCAGTCCCAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36626	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				AGATCCCAGTCCCAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36627	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				AGATCCCAGTCCCAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36628	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				AGATCCCAGTCCCAGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36629	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				CCAACAACTGGAACACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36630	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				CCAACAACTGGAACACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36631	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				CCAACAACTGGAACACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36632	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				CCAACAACTGGAACACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36633	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				TTGATAACAGTTGACTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36634	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				TTGATAACAGTTGACTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36635	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				TTGATAACAGTTGACTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36636	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				TTGATAACAGTTGACTCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36637	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				ATTCAAATGGATGTATCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36638	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				ATTCAAATGGATGTATCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36639	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				ATTCAAATGGATGTATCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36640	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				ATTCAAATGGATGTATCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36641	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				CTGCAGCTATAAAGGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36642	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				CTGCAGCTATAAAGGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36643	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				CTGCAGCTATAAAGGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36644	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				CTGCAGCTATAAAGGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36645	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				ATTAATATGAAATTGTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36646	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				ATTAATATGAAATTGTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36647	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				ATTAATATGAAATTGTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36648	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				ATTAATATGAAATTGTTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36649	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GTTTTTAGCTAGGCTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36650	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				GTTTTTAGCTAGGCTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36651	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GTTTTTAGCTAGGCTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36652	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				GTTTTTAGCTAGGCTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36653	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				TGTCTGTTTCCAACACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36654	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				TGTCTGTTTCCAACACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36655	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				TGTCTGTTTCCAACACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36656	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				TGTCTGTTTCCAACACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36657	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GTGGTATGGCTGTAGACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36658	hg19	N/A	enh14703	N/A	Enhatls41382	enhancer	E_255				GTGGTATGGCTGTAGACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36659	hg19	N/A	enh14703	N/A	N/A	enhancer	E_255				GTGGTATGGCTGTAGACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50632176	50644452	50238393	50250669	36660	hg19	N/A	enh14703	N/A	Enhatls41383	enhancer	E_255				GTGGTATGGCTGTAGACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36661	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TATACTTTCTGGTGTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36662	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TTAGAATGCAGTGTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36663	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TCACTTCTGGGGCCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36664	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TTCTCCTTCGACTTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36665	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TCTCCACAACCGGAGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36666	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				GTAGCAGCGCAGAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36667	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TGGCGCGCACGCTCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36668	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				GCCGAGGTAGACTAGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36669	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				GACAAAGTAGAGCTGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36670	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TTTGGGGGTAAGTTGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36671	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				TCCTGAAAACGGTTTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38224	chr12	50677190	50677989	50283407	50284206	36672	hg19	N/A	N/A	N/A	Enhatls41383	enhancer	E_256				ACAGCTCCTATTCTGAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LIMA1	chr12	50175787	50283520	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3534
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36673	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36674	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36675	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36676	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36677	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36678	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36679	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36680	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36681	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				ACACTAGTTTCACTGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36682	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36683	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36684	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36685	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36686	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36687	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36688	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36689	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36690	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				TCTGAGCTGACATTAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36691	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36692	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36693	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36694	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36695	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36696	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36697	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36698	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36699	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				AATAGTATACAGGTAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36700	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36701	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36702	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36703	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36704	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36705	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36706	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36707	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36708	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				CTGTCAACTGGCTCAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36709	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36710	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36711	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36712	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36713	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36714	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36715	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36716	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36717	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				TATTTATTTTCATTCGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36718	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36719	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36720	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36721	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36722	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36723	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36724	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36725	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36726	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				GTTCCCAGAAATGAATAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36727	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36728	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36729	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36730	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36731	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36732	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36733	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36734	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36735	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				TTACTGTAATGGACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36736	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36737	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36738	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36739	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36740	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36741	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36742	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36743	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36744	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				TGGTGGTTGGGTGCCACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36745	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36746	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36747	hg19	N/A	enh14705	fant41687	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36748	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36749	hg19	N/A	enh14705	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36750	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					FAM186A	chr12	50326229	50396622	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38232	chr12	50780945	50796661	50387162	50402878	36751	hg19	N/A	N/A	N/A	Enhatls41391	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3542
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36752	hg19	N/A	enh62267	N/A	N/A	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38233	chr12	50780945	50796661	50387162	50402878	36753	hg19	N/A	enh62267	N/A	Enhatls41392	enhancer	E_257				TACATTTTTTCTCATACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCD1	direct	Highly Significant	NA					LARP4	chr12	50392382	50480004	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3543
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36754	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36755	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36756	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36757	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36758	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36759	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36760	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36761	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36762	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36763	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36764	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36765	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36766	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36767	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36768	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36769	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36770	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGGGTGCACTCCCCCTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36771	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36772	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36773	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36774	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36775	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36776	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36777	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36778	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36779	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36780	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36781	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36782	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36783	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36784	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36785	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36786	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36787	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				ACCAAGTTCAGCTTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36788	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36789	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36790	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36791	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36792	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36793	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36794	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36795	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36796	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36797	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36798	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36799	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36800	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36801	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36802	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36803	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36804	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				TGCCTGGAGGGACTAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36805	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36806	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36807	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36808	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36809	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36810	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36811	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36812	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36813	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36814	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36815	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36816	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36817	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36818	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36819	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36820	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36821	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CGCAGCTAGTGCACAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36822	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36823	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36824	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36825	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36826	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36827	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36828	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36829	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36830	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36831	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36832	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36833	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36834	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36835	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36836	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36837	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36838	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CTGTCCTGACCGCCCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36839	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36840	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36841	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36842	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36843	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36844	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36845	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36846	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36847	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36848	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36849	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36850	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36851	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36852	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36853	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36854	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36855	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CTTGGGAAGGTGTAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36856	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36857	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36858	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36859	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36860	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36861	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36862	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36863	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36864	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36865	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36866	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36867	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36868	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36869	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36870	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36871	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36872	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGAGGGCCAGAGCCCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36873	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36874	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36875	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36876	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36877	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36878	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36879	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36880	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36881	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36882	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36883	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36884	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36885	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36886	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36887	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36888	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36889	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GCTATTTTTAGCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36890	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36891	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36892	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36893	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36894	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36895	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36896	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36897	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36898	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36899	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36900	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36901	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36902	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36903	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36904	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36905	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36906	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGTGCGGTTCCGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36907	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36908	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36909	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36910	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36911	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36912	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36913	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36914	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36915	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36916	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36917	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36918	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36919	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36920	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36921	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36922	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36923	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				TATGGCCAAAGCTCGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36924	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36925	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36926	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36927	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36928	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36929	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36930	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36931	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36932	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36933	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36934	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36935	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36936	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36937	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36938	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36939	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36940	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GCTCGGCCGGGGAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36941	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36942	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36943	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36944	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36945	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36946	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36947	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36948	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36949	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36950	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36951	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36952	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36953	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36954	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36955	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36956	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36957	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CCGAAGGGAACCTACCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36958	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36959	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36960	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36961	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36962	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36963	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36964	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36965	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36966	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36967	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36968	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36969	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36970	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36971	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36972	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36973	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36974	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AAGGAGATGGGTGTACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36975	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36976	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36977	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36978	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36979	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36980	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36981	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36982	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36983	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36984	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36985	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36986	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36987	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36988	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	36989	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	36990	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	36991	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGGTCAGACTGGAAACTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	36992	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	36993	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	36994	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36995	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36996	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36997	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36998	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	36999	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37000	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37001	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37002	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37003	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37004	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37005	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37006	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37007	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37008	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				TAGGGGGTTGGGGTTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37009	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37010	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37011	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37012	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37013	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37014	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37015	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37016	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37017	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37018	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37019	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37020	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37021	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37022	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37023	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37024	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37025	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGCAAGGACCCTGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37026	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37027	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37028	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37029	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37030	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37031	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37032	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37033	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37034	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37035	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37036	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37037	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37038	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37039	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37040	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37041	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37042	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GAAGTTACTATAAAGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37043	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37044	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37045	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37046	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37047	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37048	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37049	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37050	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37051	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37052	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37053	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37054	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37055	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37056	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37057	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37058	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37059	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGAGAATTCATTTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37060	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37061	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37062	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37063	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37064	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37065	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37066	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37067	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37068	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37069	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37070	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37071	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37072	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37073	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37074	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37075	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37076	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CATCTGGCTACTTAACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37077	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37078	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37079	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37080	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37081	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37082	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37083	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37084	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37085	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37086	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37087	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37088	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37089	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37090	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37091	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37092	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37093	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				ACCCCGTACCCTAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37094	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37095	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37096	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37097	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37098	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37099	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37100	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37101	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37102	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37103	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37104	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37105	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37106	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37107	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37108	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37109	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37110	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				TCCGGGCTCCAGCCCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37111	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37112	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37113	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37114	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37115	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37116	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37117	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37118	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37119	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37120	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37121	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37122	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37123	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37124	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37125	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37126	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37127	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGATGGGAGGGCAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37128	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37129	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37130	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37131	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37132	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37133	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37134	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37135	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37136	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37137	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37138	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37139	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37140	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37141	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37142	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37143	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37144	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGGCTGGGCCCATTTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37145	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37146	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37147	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37148	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37149	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37150	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37151	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37152	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37153	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37154	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37155	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37156	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37157	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37158	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37159	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37160	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37161	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GTCTGCTGTTTGTCCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37162	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37163	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37164	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37165	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37166	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37167	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37168	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37169	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37170	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37171	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37172	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37173	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37174	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37175	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37176	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37177	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37178	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				ACGCTGGGCCCAGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37179	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37180	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37181	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37182	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37183	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37184	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37185	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37186	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37187	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37188	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37189	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37190	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37191	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37192	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37193	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37194	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37195	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGGAGAGCTCTGTACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37196	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37197	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37198	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37199	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37200	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37201	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37202	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37203	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37204	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37205	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37206	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37207	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37208	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37209	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37210	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37211	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37212	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGGTGCTTCTCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37213	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37214	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37215	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37216	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37217	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37218	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37219	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37220	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37221	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37222	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37223	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37224	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37225	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37226	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37227	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37228	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37229	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GCCACACAGCTGAGCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37230	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37231	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37232	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37233	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37234	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37235	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37236	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37237	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37238	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37239	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37240	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37241	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37242	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37243	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37244	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37245	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37246	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGAGACTTGTCAGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37247	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37248	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37249	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37250	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37251	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37252	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37253	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37254	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37255	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37256	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37257	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37258	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37259	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37260	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37261	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37262	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37263	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGCACGTCAGAGTTGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37264	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37265	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37266	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37267	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37268	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37269	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37270	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37271	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37272	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37273	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37274	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37275	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37276	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37277	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37278	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37279	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37280	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				ATCCTAAGAGAGTTTTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37281	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37282	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37283	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37284	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37285	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37286	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37287	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37288	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37289	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37290	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37291	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37292	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37293	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37294	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37295	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37296	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37297	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGGTGCCAGATAGACACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37298	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37299	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37300	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37301	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37302	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37303	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37304	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37305	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37306	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37307	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37308	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37309	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37310	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37311	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37312	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37313	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37314	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CAGCTGCTCTGTCTTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37315	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37316	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37317	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37318	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37319	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37320	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37321	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37322	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37323	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37324	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37325	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37326	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37327	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37328	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37329	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37330	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37331	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CCCGGAGACTAGGACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37332	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37333	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37334	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37335	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37336	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37337	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37338	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37339	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37340	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37341	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37342	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37343	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37344	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37345	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37346	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37347	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37348	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				TGTCTGGGCGGATGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37349	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37350	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37351	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37352	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37353	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37354	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37355	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37356	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37357	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37358	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37359	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37360	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37361	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37362	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37363	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37364	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37365	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				AGTGACATCCCAGAAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37366	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37367	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37368	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37369	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37370	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37371	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37372	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37373	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37374	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37375	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37376	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37377	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37378	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37379	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37380	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37381	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37382	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GCCTGCTGACCCTCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37383	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37384	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37385	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37386	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37387	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37388	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37389	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37390	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37391	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37392	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37393	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37394	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37395	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37396	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37397	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37398	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37399	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GCCCCAGCAACAACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37400	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37401	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37402	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37403	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37404	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37405	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37406	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37407	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37408	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37409	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37410	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37411	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37412	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37413	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37414	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37415	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37416	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				GGGGTCAGCGCTGGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37417	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37418	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37419	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37420	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37421	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37422	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37423	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37424	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37425	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37426	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37427	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37428	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37429	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37430	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37431	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37432	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37433	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CAACCCAAGACCTTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38473	chr12	52442749	52468796	52048965	52075012	37434	hg19	N/A	N/A	N/A	Enhatls41635	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3783
enhrx-38474	chr12	52442749	52468796	52048965	52075012	37435	hg19	N/A	N/A	N/A	Enhatls41636	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3784
enhrx-38475	chr12	52442749	52468796	52048965	52075012	37436	hg19	N/A	N/A	N/A	Enhatls41637	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3785
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37437	hg19	N/A	N/A	N/A	Enhatls41638	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37438	hg19	N/A	enh86109	N/A	Enhatls41638	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37439	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37440	hg19	N/A	enh86109	N/A	Enhatls41639	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37441	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37442	hg19	N/A	enh86109	N/A	Enhatls41640	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37443	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37444	hg19	N/A	enh86109	N/A	Enhatls41641	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37445	hg19	N/A	enh86109	N/A	N/A	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37446	hg19	N/A	enh86109	N/A	Enhatls41642	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38476	chr12	52442749	52468796	52048965	52075012	37447	hg19	N/A	N/A	N/A	Enhatls41642	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					NR4A1	chr12	52022831	52059507	4505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3786
enhrx-38477	chr12	52442749	52468796	52048965	52075012	37448	hg19	N/A	N/A	N/A	Enhatls41643	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3787
enhrx-38478	chr12	52442749	52468796	52048965	52075012	37449	hg19	N/A	N/A	N/A	Enhatls41644	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3788
enhrx-38479	chr12	52442749	52468796	52048965	52075012	37450	hg19	N/A	N/A	N/A	Enhatls41645	enhancer	E_260				CTGCCAAGCAGACAGGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					ATG101	chr12	52069977	52077495	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3789
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37451	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37452	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37453	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37454	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37455	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37456	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37457	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37458	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37459	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37460	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37461	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37462	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37463	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37464	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37465	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37466	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37467	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37468	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37469	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37470	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37471	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGCCAGTAGGGATCAGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37472	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37473	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37474	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37475	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37476	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37477	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37478	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37479	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37480	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37481	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37482	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37483	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37484	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37485	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37486	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37487	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37488	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37489	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37490	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37491	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37492	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TCTGTGCAATCAATATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37493	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37494	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37495	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37496	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37497	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37498	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37499	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37500	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37501	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37502	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37503	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37504	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37505	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37506	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37507	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37508	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37509	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37510	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37511	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37512	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37513	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				CCAGTGAATGGTCAATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37514	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37515	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37516	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37517	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37518	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37519	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37520	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37521	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37522	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37523	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37524	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37525	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37526	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37527	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37528	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37529	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37530	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37531	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37532	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37533	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37534	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TTGGAATTCGAATTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37535	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37536	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37537	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37538	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37539	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37540	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37541	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37542	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37543	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37544	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37545	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37546	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37547	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37548	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37549	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37550	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37551	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37552	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37553	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37554	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37555	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				ATAGTTCTCTAAGTGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37556	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37557	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37558	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37559	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37560	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37561	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37562	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37563	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37564	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37565	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37566	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37567	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37568	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37569	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37570	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37571	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37572	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37573	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37574	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37575	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37576	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				CCTAGACACCTCTGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37577	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37578	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37579	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37580	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37581	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37582	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37583	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37584	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37585	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37586	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37587	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37588	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37589	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37590	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37591	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37592	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37593	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37594	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37595	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37596	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37597	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TATGAACTCAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37598	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37599	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37600	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37601	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37602	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37603	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37604	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37605	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37606	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37607	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37608	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37609	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37610	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37611	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37612	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37613	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37614	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37615	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37616	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37617	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37618	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				CGGAGACAGGAGCCTGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37619	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37620	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37621	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37622	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37623	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37624	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37625	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37626	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37627	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37628	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37629	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37630	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37631	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37632	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37633	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37634	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37635	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37636	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37637	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37638	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37639	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				AGCGCCCTGCAGCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37640	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37641	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37642	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37643	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37644	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37645	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37646	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37647	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37648	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37649	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37650	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37651	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37652	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37653	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37654	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37655	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37656	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37657	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37658	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37659	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37660	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGAATCGTGGAAAGTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37661	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37662	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37663	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37664	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37665	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37666	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37667	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37668	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37669	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37670	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37671	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37672	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37673	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37674	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37675	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37676	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37677	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37678	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37679	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37680	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37681	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GCTGGGAGAACCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37682	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37683	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37684	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37685	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37686	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37687	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37688	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37689	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37690	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37691	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37692	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37693	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37694	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37695	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37696	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37697	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37698	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37699	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37700	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37701	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37702	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGCTTCAAAGAACTTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37703	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37704	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37705	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37706	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37707	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37708	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37709	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37710	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37711	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37712	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37713	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37714	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37715	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37716	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37717	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37718	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37719	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37720	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37721	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37722	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37723	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TTGATGGTCCCTACCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37724	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37725	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37726	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37727	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37728	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37729	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37730	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37731	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37732	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37733	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37734	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37735	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37736	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37737	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37738	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37739	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37740	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37741	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37742	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37743	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37744	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TGTGCCAGGTGCTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37745	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37746	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37747	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37748	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37749	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37750	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37751	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37752	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37753	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37754	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37755	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37756	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37757	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37758	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37759	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37760	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37761	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37762	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37763	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37764	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37765	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGATGAGCTTTGCTGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37766	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37767	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37768	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37769	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37770	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37771	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37772	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37773	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37774	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37775	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37776	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37777	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37778	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37779	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37780	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37781	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37782	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37783	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37784	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37785	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37786	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGGCACACATGTGGAAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37787	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37788	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37789	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37790	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37791	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37792	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37793	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37794	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37795	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37796	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37797	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37798	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37799	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37800	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37801	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37802	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37803	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37804	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37805	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37806	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37807	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GCCCACAGGGCTCCAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37808	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37809	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37810	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37811	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37812	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37813	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37814	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37815	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37816	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37817	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37818	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37819	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37820	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37821	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37822	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37823	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37824	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37825	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37826	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37827	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37828	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				CCGTGAGTCACCCCATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37829	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37830	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37831	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37832	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37833	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37834	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37835	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37836	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37837	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37838	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37839	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37840	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37841	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37842	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37843	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37844	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37845	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37846	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37847	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37848	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37849	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				TCTCCTCTCACACAACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37850	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37851	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37852	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37853	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37854	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37855	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37856	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37857	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37858	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37859	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37860	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37861	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37862	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37863	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37864	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37865	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37866	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37867	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37868	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37869	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37870	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				AGCGGGGATGGCGTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37871	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37872	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37873	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37874	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37875	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37876	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37877	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37878	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37879	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37880	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37881	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37882	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37883	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37884	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37885	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37886	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37887	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37888	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37889	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37890	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37891	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				CCGAGGGGCAGAGTGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37892	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37893	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37894	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37895	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37896	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37897	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37898	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37899	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37900	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37901	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37902	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37903	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37904	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37905	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37906	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37907	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37908	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37909	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37910	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37911	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37912	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				AGGCAGACTGCCTCCACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37913	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37914	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37915	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37916	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37917	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37918	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37919	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37920	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37921	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37922	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37923	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37924	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37925	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37926	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37927	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37928	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37929	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37930	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37931	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37932	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37933	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGAGAGAAGTCCTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37934	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37935	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37936	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37937	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37938	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37939	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37940	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37941	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37942	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37943	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37944	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37945	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37946	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37947	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37948	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37949	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37950	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37951	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37952	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37953	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37954	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGGGCTGAGCCTAAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38489	chr12	52622205	52645698	52228421	52251914	37955	hg19	N/A	N/A	fant41767	N/A	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	2633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3799
enhrx-38490	chr12	52622205	52645698	52228421	52251914	37956	hg19	N/A	N/A	fant41768	N/A	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1888				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3800
enhrx-38491	chr12	52622205	52645698	52228421	52251914	37957	hg19	N/A	N/A	fant41769	N/A	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	1179				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3801
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37958	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37959	hg19	N/A	N/A	fant41770	Enhatls41661	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38492	chr12	52622205	52645698	52228421	52251914	37960	hg19	N/A	N/A	N/A	Enhatls41661	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3802
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37961	hg19	N/A	N/A	N/A	Enhatls41662	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37962	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37963	hg19	N/A	enh80195	fant41771	Enhatls41662	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37964	hg19	N/A	enh80195	N/A	Enhatls41662	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37965	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37966	hg19	N/A	enh80195	N/A	Enhatls41663	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37967	hg19	N/A	enh80195	N/A	N/A	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37968	hg19	N/A	enh80195	N/A	Enhatls41664	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38493	chr12	52622205	52645698	52228421	52251914	37969	hg19	N/A	N/A	N/A	Enhatls41664	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-38494	chr12	52622205	52645698	52228421	52251914	37970	hg19	N/A	N/A	N/A	Enhatls41665	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-38495	chr12	52622205	52645698	52228421	52251914	37971	hg19	N/A	N/A	N/A	Enhatls41666	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-38496	chr12	52622205	52645698	52228421	52251914	37972	hg19	N/A	N/A	N/A	Enhatls41667	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-38497	chr12	52622205	52645698	52228421	52251914	37973	hg19	N/A	N/A	N/A	Enhatls41668	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT7	chr12	52233242	52248921	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37974	hg19	N/A	N/A	N/A	Enhatls41669	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38498	chr12	52622205	52645698	52228421	52251914	37975	hg19	N/A	enh80196	N/A	Enhatls41669	enhancer	E_261				GGGTTTGGTCAGGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT86	chr12	52249299	52309163	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3808
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37976	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37977	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37978	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37979	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37980	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37981	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37982	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37983	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37984	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATTTCCTGCTACGGTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37985	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37986	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37987	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37988	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37989	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37990	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37991	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37992	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37993	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CTTCCCGGAATGTCTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37994	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37995	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37996	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37997	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37998	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	37999	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38000	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38001	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38002	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ACGGGTGGCTCTGCGGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38003	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38004	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38005	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38006	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38007	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38008	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38009	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38010	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38011	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGGGAGTGGCCCCTCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38012	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38013	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38014	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38015	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38016	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38017	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38018	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38019	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38020	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCCCGAGAGACCCCTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38021	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38022	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38023	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38024	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38025	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38026	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38027	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38028	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38029	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGCGCTAGAGCCGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38030	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38031	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38032	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38033	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38034	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38035	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38036	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38037	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38038	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGGTGCTGGATGAGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38039	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38040	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38041	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38042	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38043	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38044	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38045	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38046	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38047	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GGAGAGCCTGACTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38048	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38049	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38050	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38051	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38052	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38053	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38054	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38055	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38056	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GAATTTGTCCCGCTCTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38057	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38058	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38059	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38060	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38061	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38062	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38063	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38064	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38065	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTTCTGTCCCCACAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38066	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38067	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38068	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38069	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38070	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38071	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38072	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38073	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38074	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCTTTATGAGTGTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38075	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38076	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38077	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38078	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38079	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38080	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38081	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38082	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38083	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TAAGCTCTTCCCCACTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38084	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38085	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38086	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38087	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38088	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38089	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38090	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38091	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38092	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TTACTCAGAGCTAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38093	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38094	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38095	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38096	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38097	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38098	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38099	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38100	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38101	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGGGATTGAGCCTGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38102	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38103	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38104	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38105	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38106	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38107	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38108	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38109	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38110	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				ATCAACTGGAAGGAGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	indirect	Non Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38111	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38112	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38113	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38114	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38115	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38116	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38117	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38118	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38119	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGAGGGGAGTTGGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38120	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38121	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38122	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38123	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38124	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38125	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38126	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38127	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38128	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CGGAGCCGCTGGCTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38129	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38130	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38131	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38132	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38133	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38134	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38135	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38136	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38137	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CAGGCGTGGACCTCCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38138	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38139	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38140	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38141	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38142	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38143	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38144	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38145	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38146	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCGGCGCAGAGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38147	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38148	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38149	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38150	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38151	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38152	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38153	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38154	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38155	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCTGAGGGCGGAGGGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38156	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38157	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38158	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38159	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38160	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38161	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38162	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38163	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38164	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				CCTGTGCCCTTGGCAACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38165	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38166	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38167	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38168	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38169	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38170	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38171	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38172	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38173	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				TGACTTGGTGAGCGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38174	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38175	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38176	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38177	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38178	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38179	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38180	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38181	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38182	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GCCACCACTAACCGACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38183	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38184	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38185	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38186	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38187	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38188	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38189	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38190	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38191	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				GACATCAGACATCCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38192	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	18916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38193	hg19	N/A	enh14733	fant41790	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38194	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	21799				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38195	hg19	N/A	enh14733	fant41791	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT78	chr12	52837803	52848994	22208				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38196	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20649				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38197	hg19	N/A	enh14733	fant41792	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	20460				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38198	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17706				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38199	hg19	N/A	enh14733	fant41793	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	17538				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38658	chr12	53262407	53273843	52868623	52880059	38200	hg19	N/A	enh14733	N/A	Enhatls41825	enhancer	E_263				AGTTCAAGCAGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					KRT8	chr12	52897186	52949882	5506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3968
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38201	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				GCTAGAAATACATGGTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38202	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TGTCACTCCTGTTCAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38203	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				CCATGGGCTAAATTGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38204	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				AACTATCCACTTTTAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38205	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TCAGTTGACAATGAGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38206	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TCTTGTTCGAGCAAAGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38207	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				GGATCATCCAGAGCGTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38208	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				AGTACCATTTCACTTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38209	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TCAGGGGCCTGAGAAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38210	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TGCAGAGCACATGTTCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38211	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				TACCTGGCTCCTGGAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38212	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				AACCTTGTGGAATGCCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-38667	chr12	53384543	53388030	52990759	52994246	38213	hg19	N/A	enh14738	N/A	Enhatls41835	enhancer	E_264				ATAGCCAGGTCACCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A1	direct	Highly Significant	NA					EIF4B	chr12	53006455	53042215	10605				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3977
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38214	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38215	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38216	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38217	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38218	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38219	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38220	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38221	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				AGCCAGTCTGCAAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38222	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38223	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38224	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38225	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38226	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38227	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38228	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38229	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				CTAAGTTTGCTTCCACCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38230	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38231	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38232	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38233	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38234	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38235	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38236	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38237	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				TTTGCCCTCTAGTAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38238	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38239	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38240	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38241	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38242	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38243	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38244	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38245	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				TTCCTGGGGCCCCCCACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38246	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38247	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38248	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38249	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38250	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38251	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38252	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38253	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				GTGCTTCAACTGGACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38254	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38255	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38256	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38257	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38258	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38259	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38260	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38261	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				AGAACCAGAAAGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38262	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38263	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38264	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38265	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38266	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38267	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38268	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38269	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				CTGTGTTGGTCTGGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38270	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38271	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38272	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38273	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38274	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38275	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38276	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38277	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				ATCTCACCCTTGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38278	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38279	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38280	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38281	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38282	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38283	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38284	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38285	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				AGGCACCTGGGACGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39563	chr12	58021261	58027119	57627478	57633336	38286	hg19	N/A	N/A	N/A	Enhatls42773	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4873
enhrx-39564	chr12	58021261	58027119	57627478	57633336	38287	hg19	N/A	N/A	N/A	Enhatls42774	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4874
enhrx-39565	chr12	58021261	58027119	57627478	57633336	38288	hg19	N/A	N/A	N/A	Enhatls42775	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4875
enhrx-39566	chr12	58021261	58027119	57627478	57633336	38289	hg19	N/A	N/A	N/A	Enhatls42776	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4876
enhrx-39567	chr12	58021261	58027119	57627478	57633336	38290	hg19	N/A	N/A	N/A	Enhatls42777	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4877
enhrx-39568	chr12	58021261	58027119	57627478	57633336	38291	hg19	N/A	N/A	N/A	Enhatls42778	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4878
enhrx-39569	chr12	58021261	58027119	57627478	57633336	38292	hg19	N/A	N/A	N/A	Enhatls42779	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4879
enhrx-39570	chr12	58021261	58027119	57627478	57633336	38293	hg19	N/A	N/A	N/A	Enhatls42780	enhancer	E_265				GAAGGATGGGCGAATCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					B4GALNT1	chr12	57623408	57633239	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4880
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38294	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38295	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38296	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38297	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38298	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38299	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38300	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				AAATGTGACAGAGTTGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38301	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38302	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38303	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38304	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38305	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38306	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38307	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GAGGCACGTGGAGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38308	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38309	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38310	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38311	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38312	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38313	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38314	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCACAGGTCGAGGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38315	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38316	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38317	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38318	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38319	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38320	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38321	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				ATGAAGGTCTCCGTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38322	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38323	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38324	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38325	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38326	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38327	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38328	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GGCGCCGTCAGGGTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38329	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38330	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38331	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38332	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38333	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38334	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38335	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GGAATTTTACAAGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38336	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38337	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38338	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38339	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38340	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38341	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38342	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CTGAGGCGCCAGCGGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38343	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38344	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38345	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38346	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38347	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38348	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38349	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TTGAGGCCGGAGGAGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38350	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38351	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38352	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38353	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38354	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38355	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38356	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GTTGAGGAGAGAGTGCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38357	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38358	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38359	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38360	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38361	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38362	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38363	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCAGGTTTCCGTACCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38364	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38365	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38366	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38367	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38368	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38369	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38370	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CTCAAGTTACCCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38371	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38372	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38373	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38374	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38375	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38376	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38377	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				ACTGGGGGAACCGGAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38378	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38379	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38380	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38381	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38382	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38383	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38384	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TTGGGGCTCAACCTGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38385	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38386	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38387	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38388	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38389	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38390	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38391	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TCGGGACCCGCAGCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38392	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38393	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38394	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38395	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38396	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38397	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38398	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCAGTCCGCAAGCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38399	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38400	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38401	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38402	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38403	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38404	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38405	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GACAGTGCGCACCGTGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38406	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38407	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38408	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38409	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38410	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38411	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38412	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCGCGGCGCCCTGCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38413	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38414	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38415	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38416	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38417	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38418	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38419	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CCAGTCAACGCCCTTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38420	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38421	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38422	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38423	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38424	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38425	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38426	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CATCACACTCAAACTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38427	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38428	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38429	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38430	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38431	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38432	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38433	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CTCGACCGAGATGATCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38434	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38435	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38436	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38437	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38438	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38439	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38440	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TTTAAGCCGCAAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38441	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38442	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38443	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38444	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38445	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38446	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38447	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GGGGCGGTGTGGCTACACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38448	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38449	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38450	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38451	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38452	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38453	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38454	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TCATGGGCATCCGTTCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38455	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38456	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38457	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38458	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38459	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38460	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38461	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GTCGAGGCTACACGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38462	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38463	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38464	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38465	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38466	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38467	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38468	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CCAGAAAGCTGGGCGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38469	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38470	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38471	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38472	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38473	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38474	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38475	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				AGTGTTCCATCGCGTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38476	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38477	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38478	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38479	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38480	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38481	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38482	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TCTGGGTCATGGTCTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38483	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38484	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38485	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38486	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38487	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38488	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38489	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				CCTCACCCAAAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38490	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38491	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38492	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38493	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38494	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38495	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38496	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCACCCAGGAACAGTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38497	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38498	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38499	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38500	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38501	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38502	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38503	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				AAAGCCTTATAGCCTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38504	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38505	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38506	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38507	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38508	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38509	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38510	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				GCTGGGCTCACTGGTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39596	chr12	58156761	58167952	57762978	57774169	38511	hg19	N/A	N/A	N/A	Enhatls42804	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4906
enhrx-39597	chr12	58156761	58167952	57762978	57774169	38512	hg19	N/A	N/A	N/A	Enhatls42805	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4907
enhrx-39598	chr12	58156761	58167952	57762978	57774169	38513	hg19	N/A	N/A	N/A	Enhatls42806	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4908
enhrx-39599	chr12	58156761	58167952	57762978	57774169	38514	hg19	N/A	N/A	N/A	Enhatls42807	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4909
enhrx-39600	chr12	58156761	58167952	57762978	57774169	38515	hg19	N/A	N/A	N/A	Enhatls42808	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4910
enhrx-39601	chr12	58156761	58167952	57762978	57774169	38516	hg19	N/A	N/A	N/A	Enhatls42809	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4911
enhrx-39602	chr12	58156761	58167952	57762978	57774169	38517	hg19	N/A	N/A	N/A	Enhatls42810	enhancer	E_266				TCCTCCAGGAAGGGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CYP27B1	chr12	57762333	57768986	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4912
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38518	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				ACGTACTTTAAAAACGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38519	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				CCTCTGGAGTGGGGCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38520	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				GAAGTGATCTAATAGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38521	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				TGTAGCACCAGCCAGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38522	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				GTGTGTAGCCCCTCCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39626	chr12	58230851	58232927	57837068	57839144	38523	hg19	N/A	enh14761	N/A	Enhatls42835	enhancer	E_267				CTAAGCATTCCAGGAGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4936
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38524	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CTCTGGCTAAAGGCTGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38525	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				CTCTGGCTAAAGGCTGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38526	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CTCTGGCTAAAGGCTGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38527	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TCCACCACCATGCGGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38528	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				TCCACCACCATGCGGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38529	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TCCACCACCATGCGGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38530	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				ACAAAGCAAGTGCTAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38531	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				ACAAAGCAAGTGCTAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38532	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				ACAAAGCAAGTGCTAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38533	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				ACAAACGAGGTAGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38534	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				ACAAACGAGGTAGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38535	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				ACAAACGAGGTAGATCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38536	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TGGCAGTGCTGACAGCATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38537	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				TGGCAGTGCTGACAGCATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38538	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TGGCAGTGCTGACAGCATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38539	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GGAGTGAATTTGACACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38540	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				GGAGTGAATTTGACACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38541	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GGAGTGAATTTGACACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38542	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CAAAACCACAGTAGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38543	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				CAAAACCACAGTAGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38544	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CAAAACCACAGTAGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38545	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				AAACCCTTCCTGTAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38546	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				AAACCCTTCCTGTAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38547	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				AAACCCTTCCTGTAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38548	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				AAGAGTGTCTTGAACATAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38549	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				AAGAGTGTCTTGAACATAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38550	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				AAGAGTGTCTTGAACATAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38551	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GCCGAGGCAAGAACCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38552	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				GCCGAGGCAAGAACCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38553	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GCCGAGGCAAGAACCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38554	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CTGGACACTGCGGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38555	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				CTGGACACTGCGGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38556	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CTGGACACTGCGGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38557	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GCGCCGGCCCCGCATTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38558	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				GCGCCGGCCCCGCATTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38559	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GCGCCGGCCCCGCATTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38560	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CCGCGCTCCACTTAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38561	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				CCGCGCTCCACTTAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38562	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				CCGCGCTCCACTTAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38563	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GGGATTGCCGAAAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38564	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				GGGATTGCCGAAAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38565	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GGGATTGCCGAAAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38566	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GTATAGAGCGTCAGAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38567	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				GTATAGAGCGTCAGAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38568	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				GTATAGAGCGTCAGAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38569	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TTATAGTGAACTCCAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	12914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38570	hg19	N/A	enh14762	fant41983	Enhatls42836	enhancer	E_268				TTATAGTGAACTCCAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18636				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58257369	58261060	57863586	57867277	38571	hg19	N/A	enh14762	N/A	Enhatls42836	enhancer	E_268				TTATAGTGAACTCCAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	18880				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38572	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38573	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38574	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38575	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38576	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38577	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38578	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCTGGTAGGGCCTCCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38579	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38580	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38581	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38582	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38583	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38584	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38585	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCTGCCCTAAACTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38586	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38587	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38588	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38589	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38590	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38591	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38592	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CGGCATATTCCATACTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38593	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38594	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38595	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38596	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38597	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38598	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38599	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGTGTTCTGCCAGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38600	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38601	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38602	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38603	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38604	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38605	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38606	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TATAATTTCATCCAAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38607	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38608	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38609	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38610	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38611	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38612	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38613	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTTTTCCTGTCGAGCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38614	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38615	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38616	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38617	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38618	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38619	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38620	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCAAACGTAATTACAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38621	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38622	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38623	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38624	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38625	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38626	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38627	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGTTCCAGCATGTTGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38628	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38629	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38630	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38631	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38632	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38633	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38634	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCGGGGAGTAGGGATCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38635	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38636	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38637	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38638	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38639	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38640	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38641	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGGATGGGCTACGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38642	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38643	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38644	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38645	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38646	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38647	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38648	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GCCACCAGCTTCTCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38649	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38650	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38651	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38652	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38653	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38654	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38655	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTTCGGCCAGTGACACTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38656	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38657	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38658	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38659	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38660	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38661	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38662	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAATTCTCTCCCGCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38663	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38664	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38665	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38666	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38667	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38668	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38669	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTAAACAGGCCACCTTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38670	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38671	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38672	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38673	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38674	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38675	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38676	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TTGATTCCGTGGACGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38677	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38678	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38679	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38680	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38681	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38682	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38683	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAGGGGCAGAGGGTTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38684	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38685	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38686	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38687	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38688	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38689	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38690	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				CTTCAATCCAAGCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38691	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38692	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38693	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38694	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38695	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38696	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38697	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TCGCTTTTCACTTAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38698	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38699	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38700	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38701	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38702	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38703	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38704	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				TGGTGTGGCAGCGGCTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38705	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38706	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38707	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38708	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38709	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38710	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38711	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GAAGCAGACTCAAAGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38712	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38713	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38714	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38715	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38716	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38717	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38718	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GGACTCGGAAGGAGGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38719	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	39216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38720	hg19	N/A	enh2398	fant41987	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41126				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38721	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	41527				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38722	hg19	N/A	enh2398	fant41988	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	42858				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38723	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					CTDSP2	chr12	57819926	57846729	43174				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38724	hg19	N/A	enh2398	fant41989	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	44117				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39627	chr12	58280756	58294652	57886973	57900869	38725	hg19	N/A	enh2398	N/A	Enhatls42836	enhancer	E_269				GTGTGAGACGGGCCTGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	39435				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4937
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38726	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GCTGAGAGGTAGAAGTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38727	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GTAAACGAATGGGTACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38728	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GAAAAACACTGCTTTCAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38729	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GCAGGGGTCGGGAAAGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38730	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				AGGATGGCCGAGACCTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38731	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				TGCTGCCTGCTGAGCTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38732	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GAGGGCAGCAGCGAAATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38733	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				TGAAGACGTTAGGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38734	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				TGGGCGGTCGCGTTGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38735	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GCTCCGGACGAGCGCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38736	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				CCCAGGGGAATCCCCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38737	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				GCTTAGGCTCCTGAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38738	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				CCCCTGGCCAGGTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	indirect	Non Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39630	chr12	58334126	58336365	57940343	57942582	38739	hg19	N/A	N/A	N/A	Enhatls42839	enhancer	E_270				AGACAGACTGGGCATCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK4	direct	Highly Significant	NA					ATP23	chr12	57941566	57959148	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4940
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38740	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				GACACTCTCCCTTTTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38741	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				TGTGGGCATGGCTCACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38742	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				CCTAGAGAAAGCTATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38743	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				GCAGAGAAGCTGCTATGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38744	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				GTGTGGTAGTGTTGAGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38745	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				TTAGTGACTTCCCTGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38746	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				CAGCGGGAGAGAAAGCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38747	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				TCAATATTGGGCATCCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38748	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				TAGAACTGAGGTGATGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39961	chr12	67629978	67631679	67236198	67237899	38749	hg19	N/A	enh80240	N/A	Enhatls43204	enhancer	E_272				AACAAAGTGATCCCCTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					CAND1	chr12	67269357	67319953	29783				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5271
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38750	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				AGAATCAGAGTTTTATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38751	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				GCACAGACATTTCGGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38752	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				TCCTGTCACATTTTTGTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38753	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				ATCACTCTCATGTTCCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38754	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				TGTCGCCTCTGCAGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38755	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				AAGTCAGGAGTCATCTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38756	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				ATTCAATTCTTATTCTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38757	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				ATTCTACACAACCAAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38758	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				TGGGATCAGAGACTTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38759	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				GCATTGAGAGTTGATTTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38760	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				TTTCAGAGTGCAACAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38761	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				CTTGTATTCCAGCAGGCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38762	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				ACACTCTAAGCATAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38763	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				CATTCTATAGGTATATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	direct	Highly Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-39986	chr12	68374798	68376400	67981018	67982620	38764	hg19	N/A	enh29673	N/A	Enhatls43234	enhancer	E_273				TGTTCTCTGGCGATGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CAND1	indirect	Non Significant	NA					IFNG	chr12	68154767	68159740	170773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38765	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				ACATCAAGTTACAGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38766	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				ACATCAAGTTACAGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38767	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				ACATCAAGTTACAGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38768	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				CATAATTAGAAATTGCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38769	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				CATAATTAGAAATTGCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38770	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				CATAATTAGAAATTGCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38771	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AATGCTTCCTGGAAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38772	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				AATGCTTCCTGGAAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38773	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AATGCTTCCTGGAAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38774	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCCTGAGTACCTTTGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38775	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				GCCTGAGTACCTTTGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38776	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCCTGAGTACCTTTGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38777	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GAGTGTGGAGGATTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38778	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				GAGTGTGGAGGATTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38779	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GAGTGTGGAGGATTAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38780	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TTCACTCCAGATAAGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38781	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				TTCACTCCAGATAAGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38782	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TTCACTCCAGATAAGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38783	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				ACCCCTCCTTAAACAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38784	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				ACCCCTCCTTAAACAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38785	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				ACCCCTCCTTAAACAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38786	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCAGTGCAGTTGCTTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38787	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				GCAGTGCAGTTGCTTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38788	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCAGTGCAGTTGCTTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38789	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TGATTGCACCCACACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38790	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				TGATTGCACCCACACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38791	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TGATTGCACCCACACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38792	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AATTTCTTTAAACCACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38793	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				AATTTCTTTAAACCACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38794	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AATTTCTTTAAACCACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38795	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AAAGTCAGAGAGCTATGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38796	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				AAAGTCAGAGAGCTATGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38797	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				AAAGTCAGAGAGCTATGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38798	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TTGAAATGCAAACCCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38799	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				TTGAAATGCAAACCCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38800	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				TTGAAATGCAAACCCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38801	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCTTAATTATTTCCTGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	377322				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38802	hg19	N/A	enh29840	fant42573	Enhatls44157	enhancer	E_274				GCTTAATTATTTCCTGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	381724				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-40862	chr12	90483188	90485903	90089411	90092126	38803	hg19	N/A	enh29840	N/A	Enhatls44157	enhancer	E_274				GCTTAATTATTTCCTGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	DUSP6	direct	Highly Significant	NA					ATP2B1	chr12	89588048	89709366	382334				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6172
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38804	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				CAAGCAGGCTAACCGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38805	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				ATTTGGGGCACACTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38806	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				ACGTAGCAGCCAATAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38807	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GCGGGAACCCGGAAATGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38808	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GGTTCAATGGCAAGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38809	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GGGGTTCTGACAGCTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38810	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				AAGCCGGGAAGGGTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38811	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GTCTTGGAGGGGACTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38812	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				TCCCTTTCTAGGGAAGTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38813	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GCGGGGCGGTACAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38814	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				CTTGGGGTGCGCTTTAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38815	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GGAATGACTGATGGATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-41967	chr12	108908813	108909331	108515036	108515554	38816	hg19	N/A	N/A	N/A	Enhatls45337	enhancer	E_275				GACCTGGGGACCGGGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ASCL4	direct	Highly Significant	NA					FICD	chr12	108515276	108525832	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7277
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38817	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				TGAGGGAAAACTCACAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38818	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				AAGACAGAGCAGTGGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38819	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				CTACTGTGTTTAGGAAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38820	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				AGATTCTTTCCCAACATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38821	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				TCAGTGACCTCATTGCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38822	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				GCTGGTGATATTCGAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38823	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				TATTCTTAATATGTAATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38824	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				GTACATCACACAGGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38825	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				CACGCTAAGTGATAACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38826	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				CCATTCAGTTTTCTTACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38827	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				GATGAAATACTACAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38828	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				GAAATAATCTGGCTGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38829	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				TTTCATAGCATAATAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38830	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				TTCTTACAGTGGGCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38831	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				CTAATGGTATCACTCTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44870	chr13	26305868	26308793	25731730	25734655	38832	hg19	N/A	enh30128	N/A	Enhatls48407	enhancer	E_276				GTGTTCGCATATACATACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					ATP8A2	chr13	25371973	26025851	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	492
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38833	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				AATGCTAACGAATTTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38834	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				TAAGGTGTCAGACGTCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38835	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GGAGCCCTCAACACCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38836	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				AGGCAGCGTCCTTTCCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38837	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GCGCTGAGCGACGGTGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38838	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				AGTGCCGGCTCCACCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38839	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				CCGAGCCCCCCCGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38840	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				TGCGAGGCGGGTGCGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38841	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GACCGCGGACCGGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38842	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GCAGCAACTTCAGTTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38843	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GCGGCGCCGCAGCCCGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38844	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GGCTTCTCGCCGTCACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38845	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				CCCGGGCGCCACTTACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44902	chr13	27131405	27132542	26557268	26558405	38846	hg19	N/A	N/A	N/A	Enhatls48441	enhancer	E_278				GAGGGCGCGCAGACACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					WASF3	chr13	26557682	26688948	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	524
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38847	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				CAGCACCATATGAAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38848	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				CAGCACCATATGAAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38849	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				CAGCACCATATGAAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38850	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				TCAGGTTTGTGGGATTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38851	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				TCAGGTTTGTGGGATTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38852	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				TCAGGTTTGTGGGATTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38853	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GGTCTTTCGTGCCCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38854	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GGTCTTTCGTGCCCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38855	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GGTCTTTCGTGCCCTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38856	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTATAATCAAACGTGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38857	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GTATAATCAAACGTGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38858	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTATAATCAAACGTGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38859	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GCATAAGCAGTTTCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38860	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GCATAAGCAGTTTCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38861	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GCATAAGCAGTTTCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38862	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTCATTAGTCTGCAGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38863	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GTCATTAGTCTGCAGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38864	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTCATTAGTCTGCAGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38865	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GAGACCAAATGTTCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38866	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GAGACCAAATGTTCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38867	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GAGACCAAATGTTCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38868	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ACCTCATCTGACAGATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38869	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				ACCTCATCTGACAGATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38870	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ACCTCATCTGACAGATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38871	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ATCCCTGCTCTGCTAATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38872	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				ATCCCTGCTCTGCTAATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38873	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ATCCCTGCTCTGCTAATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38874	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				CTTTAAAGCTAGATAATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38875	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				CTTTAAAGCTAGATAATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38876	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				CTTTAAAGCTAGATAATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38877	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTAAAGGCCACATCCAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38878	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				GTAAAGGCCACATCCAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38879	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				GTAAAGGCCACATCCAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38880	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ATCCTGATCTGCATAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71541				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38881	hg19	N/A	enh30146	fant43941	Enhatls48473	enhancer	E_279				ATCCTGATCTGCATAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	71217				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-44929	chr13	27926739	27928790	27352602	27354653	38882	hg19	N/A	enh30146	N/A	Enhatls48473	enhancer	E_279				ATCCTGATCTGCATAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CDK8	direct	Highly Significant	NA					GTF3A	chr13	27424618	27435823	67861				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	551
enhrx-lit693	chr13	37005641	37006447	36431504	36432310	38883	hg19					enhancer	E_280				AGTGTTGCGTCTCCATCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit694	chr13	37005641	37006447	36431504	36432310	38884	hg19					enhancer	E_280				CTACGCTTCCTGCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit695	chr13	37005641	37006447	36431504	36432310	38885	hg19					enhancer	E_280				AGAGCGACGCGGGGTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit696	chr13	37005641	37006447	36431504	36432310	38886	hg19					enhancer	E_280				GCCGCGCAGGAGACGTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit697	chr13	37005641	37006447	36431504	36432310	38887	hg19					enhancer	E_280				CGGACTCGCCCACCCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit698	chr13	37005641	37006447	36431504	36432310	38888	hg19					enhancer	E_280				GGGACGTGTGCAGACGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit699	chr13	37005641	37006447	36431504	36432310	38889	hg19					enhancer	E_280				CCTGAGGGCCCAACGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit700	chr13	37005641	37006447	36431504	36432310	38890	hg19					enhancer	E_280				CGGAGAGCGCACGCCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit701	chr13	37005641	37006447	36431504	36432310	38891	hg19					enhancer	E_280				GCGGGAAGGACCAAGTGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit702	chr13	37005641	37006447	36431504	36432310	38892	hg19					enhancer	E_280				GGAGGATCGCGGTTAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit703	chr13	37005641	37006447	36431504	36432310	38893	hg19					enhancer	E_280				AGATAACGACGGGAAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit704	chr13	37005641	37006447	36431504	36432310	38894	hg19					enhancer	E_280				TACCCTGGATCTTTTATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT20H	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38895	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				TCATGACATGAACTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38896	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				CTACTTATAAGATGCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38897	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				CATAGGTCATGGGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38898	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				TGTCTTGAAGGCTTTATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38899	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				GTCAACATCATCCTGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38900	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				ACTTGCCTGGGAAAATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38901	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				TCACCACTTTGCAGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38902	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				GCAACATATCAGGTTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38903	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				TGACGTAGCAGACCAGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38904	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				AGTCTTAAAGTGAATGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38905	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				GAAAGTTGTAAATGTGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46017	chr13	48281799	48284043	47707664	47709908	38906	hg19	N/A	enh15304	N/A	Enhatls49675	enhancer	E_281				GCAGGTCAGACAACTACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					SUCLA2	chr13	47936490	48037968	225711				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1639
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38907	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				AATTTGCTATGCTCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38908	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				CATATCACAGATGCTAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38909	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				CTTGTAAATGAAATAAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38910	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				GTTTCAAAGTGGGTAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38911	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				ACAATCCTTCTAAGGCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38912	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				ATACCCTGCCTGCCTGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38913	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				ATAAAGAGCATCCAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38914	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				AGATGGAATGAACCATAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38915	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				GTATTTCTCAGGGCAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38916	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				AGGTCAGTGAATTAGTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49378225	49380725	48804089	48806589	38917	hg19	N/A	enh51542	N/A	Enhatls49751	enhancer	E_282				TTGAGCAGATCATGAAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					CYSLTR2	chr13	48653710	48711226	92184				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38918	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				AATTTTATCTTTTAATTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38919	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				AGAGTGCAATGTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38920	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				AGATAGAGTCATACATCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38921	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				TGGGTACATTGAATACAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38922	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				GAATGAGATGCACTTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38923	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				ATGGAGAGTGGGCCAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38924	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				GAAGACCCAAACCACTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46088	chr13	49523152	49526441	48949016	48952305	38925	hg19	N/A	enh15327	N/A	Enhatls49751	enhancer	E_283				AACTTGAAGACCAATACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RB1	direct	Highly Significant	NA					FNDC3A	chr13	48975911	49209779	23133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1710
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38926	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				GAGGACTGGCAAAAGAGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38927	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				GAGGACTGGCAAAAGAGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38928	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				TTGCCTTATTTCCTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38929	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				TTGCCTTATTTCCTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38930	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				ATCCTCTCAAGGTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38931	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				ATCCTCTCAAGGTTTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38932	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				AGCCTAGAGACCCCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38933	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				AGCCTAGAGACCCCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38934	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				AACCAGAATGGCCACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38935	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				AACCAGAATGGCCACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38936	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				AATAATCTCATTATGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38937	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				AATAATCTCATTATGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38938	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				TTGTGTATATACACAGTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38939	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				TTGTGTATATACACAGTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38940	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				ATAAACATGCAGGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38941	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				ATAAACATGCAGGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38942	hg19	N/A	N/A	N/A	Enhatls50646	enhancer	E_284				GCAGCAGTGCCTATCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	250046				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46910	chr13	80380335	80386826	79806200	79812691	38943	hg19	N/A	enh30481	N/A	Enhatls50646	enhancer	E_284				GCAGCAGTGCCTATCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					NDFIP2	chr13	79481154	79556077	252054				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2532
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38944	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				CGATTAACTTTCAGTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38945	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				GTGTAAGAAAGAAGAAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38946	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				TGATTCAATATACACATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38947	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				TATGACTCATTGGTTTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38948	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				GCCAGGACAGAGAACACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38949	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				CTTCCAAAGTAAGAAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38950	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				TGGAGGCTACAACTTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38951	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				ATTTTCATTCTCAGTGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-46919	chr13	81042250	81046183	80468115	80472048	38952	hg19	N/A	enh30495	N/A	Enhatls50658	enhancer	E_286				CATATTCTGCTAAACGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRY2	direct	Highly Significant	NA					SPRY2	chr13	80335975	80341126	126125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38953	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				ACAAGGTTAGAAGCAATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38954	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GAGTGAAGCTAGAGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38955	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GATCTACTTTCCGTCCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38956	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				CTACTCCCAGGAGATCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38957	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				TGAAGTTCCCTGCTCTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38958	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GAATAGGGAACCATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38959	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GTATTAGTCACGGTCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38960	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GGAATGCTGAGCGTCTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38961	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				TTATGACTGCCAGATCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38962	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				CAATGAGGCGTATTTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38963	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				ACCTGCGTTTTGGTAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38964	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				GCTCTAAAGCTCACATTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38965	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				CTTCCGGGCAATAAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47183	chr13	98530052	98534727	97877798	97882473	38966	hg19	N/A	enh30593	N/A	Enhatls50947	enhancer	E_287				CAGTGGCTGGCACCTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					IPO5	chr13	97953657	98024296	70277				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2805
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38967	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				CAAGTTTTGAAATCAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38968	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				GCACAATAAGAACCCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38969	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				TGCATCCTTGTATTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38970	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				CAAGTCAGAAAGTCTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38971	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				GGCTCTGCAGACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38972	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				ACTACTCCATGCAAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38973	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				GTGTCTGTTCCACACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38974	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				GTGGAGCTTAAGAGACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38975	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				GCCTGGCTGATGATTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38976	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				CACCTCGTGGATACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38977	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				AATGCATTTACTATGATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47295	chr13	99629560	99630989	98977306	98978735	38978	hg19	N/A	N/A	N/A	Enhatls51075	enhancer	E_288				CCAGATGTGTGGGTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STK24	direct	Highly Significant	NA					DOCK9	chr13	98793428	99086625	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2917
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38979	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CGGCGTCACTCCACACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38980	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CCCCGTTTCAGGGAAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38981	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				TGTTCTGCCGGGACAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38982	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CCACAATGATCAGGAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38983	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CGTGCGTGAGCCACATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38984	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				GATCTGAGGAATTTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38985	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				TTATGTGCCACCAGAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38986	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				GCAGCCGCCTTCCCCTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38987	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				GGGGCGTCCACACACCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38988	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CTCATGCCTTGAGCCCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38989	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				CAATTGTTCTCACTTCGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38990	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				GTGGGCGTCTCCTCAGTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47832	chr13	113676101	113677907	113021787	113023593	38991	hg19	N/A	N/A	N/A	Enhatls51655	enhancer	E_289				TGGGGGGCGCAAGGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					MCF2L	chr13	112894377	113099742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3454
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38992	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TTACCGTGTCCCTTCTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38993	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				ATGCACAGACCCTTAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38994	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				AGAGAAAAAGTGAGGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38995	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GGAGTGGTGTCAGATGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38996	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TGGTCAAACAATTGTGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38997	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GGGATTTATTCAGTCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38998	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GTAGAGTTCCGCAGCGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	38999	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TCTAGCCGGGAGCTGTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39000	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				CTGTTGACCAAAACAGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39001	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				AGTCGAGGCGGGCGAGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39002	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				CGAGCGGGAACCCAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39003	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GGACGACCGGGAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	indirect	Non Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39004	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GCTGCGCGGGGCGTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39005	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TCGGGCCCCAAGGTCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39006	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TCCCCCGCGCCGCCCGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39007	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				CCGCGGCCGTCCGAGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39008	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TGTGGGGCGCGAGCTCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39009	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TGGGCGGGTCCCGTCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39010	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GGGTCGGCTTGGCTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39011	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				TCTGAGGCGCCAGGACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47933	chr13	114143390	114148577	113489075	113494262	39012	hg19	N/A	N/A	fant45394	N/A	enhancer	E_293				GCACCAGGCCCGTCCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMCO3	chr13	113491020	113554590	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3555
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39013	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				GGGGTGAACAGGACAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39014	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				CATTTGCTTCTAAACAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39015	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				CCGGAGACTAACATGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39016	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				CCCCAAATCACATCAGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39017	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				GTAACCTGGCACAGTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39018	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				TGTGCACATACGTGGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114476258	114478739	113773285	113775766	39019	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_294				TGTGTGGTGTGTGGTATATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39020	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				AAGAAGGAGGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39021	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				AAATGCCCATTGTGAGCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39022	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				GAACTGTGAGGCTTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39023	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				GTAAAGTGAGAGAAAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39024	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				CGAAACCTAGGACAGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39025	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				GTGGCTCAACCATCAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39026	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				GAGTGTTCTCTCTTATATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39027	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				TGCAGGAGCAGAATGTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39028	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				TCAGTAAGTTGATGTTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39029	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				CGTGCAGGGCAGTGAACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39030	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				CCTGCAGTGTTTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39031	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				ACAGCAAGAGAGGTAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39032	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				ATAGACCCACCGGAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39033	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				ACCTAAGGGTTTCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39034	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				ATCATCCCTTCATCGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47970	chr13	114487302	114489132	113784329	113786159	39035	hg19	N/A	enh30712	N/A	Enhatls51802	enhancer	E_295				GTACGTCAAGCCACTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					TMEM255B	chr13	113759225	113816995	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3592
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39036	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				GGCTGAGTGCGCGGCGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39037	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				GGCTGAGTGCGCGGCGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39038	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				GGCTGAGTGCGCGGCGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39039	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				GGCTGAGTGCGCGGCGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39040	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				TTACAGATATGTTACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39041	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				TTACAGATATGTTACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39042	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				TTACAGATATGTTACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39043	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				TTACAGATATGTTACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39044	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				GCCTAGGCCCCCACGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39045	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				GCCTAGGCCCCCACGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39046	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				GCCTAGGCCCCCACGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39047	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				GCCTAGGCCCCCACGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39048	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				GCTGCTGGACCTGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39049	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				GCTGCTGGACCTGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39050	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				GCTGCTGGACCTGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39051	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				GCTGCTGGACCTGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39052	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				GCTGGCCACAAGCGCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39053	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				GCTGGCCACAAGCGCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39054	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				GCTGGCCACAAGCGCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39055	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				GCTGGCCACAAGCGCTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39056	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				CGGGTCTGCGGCCAAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39057	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				CGGGTCTGCGGCCAAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39058	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				CGGGTCTGCGGCCAAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39059	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				CGGGTCTGCGGCCAAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39060	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				TCTGTGCTCCCAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39061	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				TCTGTGCTCCCAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39062	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				TCTGTGCTCCCAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39063	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				TCTGTGCTCCCAGCGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39064	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				CAGTGAGTCATTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39065	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				CAGTGAGTCATTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39066	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				CAGTGAGTCATTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39067	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				CAGTGAGTCATTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39068	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				CTCTGTTTATTAAAACTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39069	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				CTCTGTTTATTAAAACTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39070	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				CTCTGTTTATTAAAACTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39071	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				CTCTGTTTATTAAAACTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39072	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				TTGCCGCAAGTGAAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39073	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				TTGCCGCAAGTGAAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39074	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				TTGCCGCAAGTGAAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39075	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				TTGCCGCAAGTGAAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39076	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				GCTCATGGCAAGGACATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39077	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				GCTCATGGCAAGGACATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39078	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				GCTCATGGCAAGGACATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39079	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				GCTCATGGCAAGGACATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39080	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				AACAGCTGCGGTGACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39081	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				AACAGCTGCGGTGACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39082	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				AACAGCTGCGGTGACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39083	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				AACAGCTGCGGTGACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39084	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				AGACTGAGAAACACGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39085	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				AGACTGAGAAACACGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39086	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				AGACTGAGAAACACGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39087	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				AGACTGAGAAACACGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39088	hg19	N/A	enh64761	N/A	Enhatls51808	enhancer	E_296				ATAGCCACTAACGACCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47976	chr13	114521462	114525424	113818489	113822451	39089	hg19	N/A	N/A	N/A	Enhatls51808	enhancer	E_296				ATAGCCACTAACGACCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3598
enhrx-47977	chr13	114521462	114525424	113818489	113822451	39090	hg19	N/A	N/A	N/A	Enhatls51809	enhancer	E_296				ATAGCCACTAACGACCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3599
enhrx-47978	chr13	114521462	114525424	113818489	113822451	39091	hg19	N/A	N/A	N/A	Enhatls51810	enhancer	E_296				ATAGCCACTAACGACCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3600
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39092	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39093	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39094	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39095	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39096	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39097	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39098	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39099	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39100	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39101	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39102	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				CCGTGGGTCCCTGCACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39103	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39104	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39105	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39106	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39107	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39108	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39109	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39110	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39111	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39112	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39113	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				AGCACCCCAGGTTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39114	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39115	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39116	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39117	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39118	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39119	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39120	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39121	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39122	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39123	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39124	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				ATAAACCCATTTCCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39125	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39126	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39127	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39128	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39129	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39130	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39131	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39132	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39133	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39134	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39135	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				GCTATTTCTGTCCACTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39136	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39137	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39138	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39139	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39140	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39141	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39142	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39143	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39144	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39145	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39146	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				TGAATCTGACCAGACAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39147	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39148	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39149	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39150	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39151	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39152	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39153	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39154	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39155	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39156	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39157	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				TCTGTCCTGTCCACGCAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39158	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39159	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39160	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39161	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39162	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39163	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39164	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39165	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39166	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39167	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39168	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				AAGGTGCTCCCCCTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39169	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39170	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39171	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39172	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39173	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39174	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39175	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39176	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39177	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39178	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39179	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				GTCTGGGGTTCCCTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39180	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39181	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39182	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39183	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39184	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39185	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39186	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39187	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39188	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39189	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39190	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				GACAGAGGGAGACCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39191	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39192	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39193	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39194	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39195	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39196	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39197	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39198	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39199	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39200	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39201	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				GAGGCTCTGGGGAATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39202	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39203	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39204	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39205	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39206	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39207	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39208	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39209	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39210	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39211	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39212	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				ATGACTCACCCGGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39213	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39214	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39215	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39216	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39217	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39218	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39219	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39220	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39221	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39222	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39223	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				CCGAGCAGCTCCCTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39224	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39225	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39226	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39227	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39228	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39229	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39230	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39231	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39232	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39233	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39234	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				ACATGACCGAAAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39235	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39236	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39237	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39238	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39239	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39240	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39241	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39242	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39243	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39244	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39245	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				CCAGATCTGCCACAACAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47981	chr13	114535098	114544264	113832125	113841291	39246	hg19	N/A	N/A	N/A	Enhatls51813	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3603
enhrx-47982	chr13	114535098	114544264	113832125	113841291	39247	hg19	N/A	N/A	N/A	Enhatls51814	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3604
enhrx-47983	chr13	114535098	114544264	113832125	113841291	39248	hg19	N/A	N/A	N/A	Enhatls51815	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3605
enhrx-47984	chr13	114535098	114544264	113832125	113841291	39249	hg19	N/A	N/A	N/A	Enhatls51816	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3606
enhrx-47985	chr13	114535098	114544264	113832125	113841291	39250	hg19	N/A	N/A	N/A	Enhatls51817	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3607
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39251	hg19	N/A	N/A	N/A	Enhatls51818	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39252	hg19	N/A	enh64762	N/A	Enhatls51818	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39253	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39254	hg19	N/A	enh64762	N/A	Enhatls51819	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39255	hg19	N/A	enh64762	N/A	N/A	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47986	chr13	114535098	114544264	113832125	113841291	39256	hg19	N/A	enh64762	N/A	Enhatls51820	enhancer	E_297				GAACAAGCACAGGCCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3608
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39257	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GGTCGCCGGGGGATGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39258	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GCAGCGCTGCCTCTCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39259	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GGAGCTGTGCAGCCGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39260	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				CCTCGAAGACCTGAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39261	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GCAACAGCGCGGCTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39262	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GCGCGCTTGGTGAGTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39263	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				CAGCTGCGGCGCGCGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39264	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				GCGCGGTCAGAGCGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39265	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				CTCCGGTCATCCCGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39266	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				TCGGTCTGGGCGTGTTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39267	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				AGGAGCGTCTCCCCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-47988	chr13	114566275	114567568	113863302	113864595	39268	hg19	N/A	N/A	fant45411	N/A	enhancer	E_298				ATACCTGGTTCAACTTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MCF2L	direct	Highly Significant	NA					GAS6	chr13	113820548	113864076	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3610
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39269	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				ACCGTGCCTGCTGCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39270	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				CTCCGTGACACCATGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39271	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				GCAGGTCTACATTTCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39272	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				GGGAATTTGTTGAAATAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39273	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				TTAGATCAATGTCAGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39274	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				GGAATGCCTCCAAAATGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39275	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				GATTTCTACAACATTATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39276	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				AGGAAAAAGTATCTATACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39277	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				TAGGCAGCTGGCTACAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39278	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				AAATAAATTGATTTATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49663	chr14	51421231	51430327	50954513	50963609	39279	hg19	N/A	enh15598	N/A	Enhatls53583	enhancer	E_300				TTTTTTATCTTTATAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					TRIM9	chr14	50975261	51096061	5288				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1620
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39280	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				AGAGGGGATATTCTTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39281	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				AGAGGGGATATTCTTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39282	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				TCACTAGCTATCATAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39283	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				TCACTAGCTATCATAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39284	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				AAAAGTGCCGAGTAAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39285	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				AAAAGTGCCGAGTAAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39286	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				TTGCTGCTGCCATGTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39287	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				TTGCTGCTGCCATGTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39288	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				CTAATACACAGGGTACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39289	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				CTAATACACAGGGTACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39290	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				TTAGCTGAGAAGGGTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39291	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				TTAGCTGAGAAGGGTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39292	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				GCCCCTGAGGGTCAGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39293	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				GCCCCTGAGGGTCAGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39294	hg19	N/A	enh3190	fant46006	Enhatls53627	enhancer	E_301				AAATAGTTAAATAAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52372694	52373414	51905976	51906696	39295	hg19	N/A	enh3190	N/A	Enhatls53627	enhancer	E_301				AAATAGTTAAATAAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39296	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				TACTCTGCATAGAAACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39297	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				TACTCTGCATAGAAACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39298	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				TACTCTGCATAGAAACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39299	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				TACTCTGCATAGAAACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39300	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				GGCTTGAGGCTAACATGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39301	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GGCTTGAGGCTAACATGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39302	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				GGCTTGAGGCTAACATGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39303	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GGCTTGAGGCTAACATGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39304	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				TGCCCTAAGCAGGCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39305	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				TGCCCTAAGCAGGCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39306	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				TGCCCTAAGCAGGCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39307	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				TGCCCTAAGCAGGCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39308	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				AGTGACAAAAAAGCCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39309	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				AGTGACAAAAAAGCCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39310	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				AGTGACAAAAAAGCCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39311	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				AGTGACAAAAAAGCCTTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39312	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				GTATGGATTAGTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39313	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GTATGGATTAGTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39314	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				GTATGGATTAGTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39315	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GTATGGATTAGTCAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39316	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				AGGAAACTAGTCATTTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39317	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				AGGAAACTAGTCATTTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39318	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				AGGAAACTAGTCATTTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39319	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				AGGAAACTAGTCATTTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39320	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				CTGGTCATCATCTTTGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39321	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				CTGGTCATCATCTTTGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39322	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				CTGGTCATCATCTTTGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39323	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				CTGGTCATCATCTTTGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39324	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				GATACAATATGAGTCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39325	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GATACAATATGAGTCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39326	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				GATACAATATGAGTCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39327	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GATACAATATGAGTCCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39328	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				GTAAAGAAGTACATGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39329	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GTAAAGAAGTACATGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39330	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				GTAAAGAAGTACATGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39331	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				GTAAAGAAGTACATGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39332	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_302				CAGTATCTGCTTCTTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39333	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				CAGTATCTGCTTCTTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39334	hg19	N/A	enh43996	fant46007	Enhatls53627	enhancer	E_302				CAGTATCTGCTTCTTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52387164	52398695	51920446	51931977	39335	hg19	N/A	enh43996	N/A	Enhatls53627	enhancer	E_302				CAGTATCTGCTTCTTGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39336	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				CATGGATTGAAAAATAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39337	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				GAATATCTTAAGAACATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39338	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				CTTCATTCCTTTCCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39339	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				GAGAGGAAGATGACCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39340	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				AGAGTCGAATCAACTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39341	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				TTGGGTTTAGAGTCACGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39342	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				TAGGAAAATAAACACTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49699	chr14	52412564	52414346	51945846	51947628	39343	hg19	N/A	N/A	N/A	Enhatls53627	enhancer	E_303				TGCTTTTACGAGAAATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FRMD6	direct	Highly Significant	NA					GNG2	chr14	51826194	51979342	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1656
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39344	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				ATACTAAGTTCTTTGGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39345	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				ATACTAAGTTCTTTGGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39346	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				ATACTAAGTTCTTTGGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39347	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				ATACTAAGTTCTTTGGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39348	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				GTTACTATTATTGTTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39349	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				GTTACTATTATTGTTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39350	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				GTTACTATTATTGTTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39351	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				GTTACTATTATTGTTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39352	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				ACAACTGCGCTAAATACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39353	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				ACAACTGCGCTAAATACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39354	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				ACAACTGCGCTAAATACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39355	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				ACAACTGCGCTAAATACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39356	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AATTTTTCAGTTAATGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39357	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				AATTTTTCAGTTAATGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39358	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AATTTTTCAGTTAATGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39359	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				AATTTTTCAGTTAATGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39360	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				TTCCTTTCATTCACAGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39361	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				TTCCTTTCATTCACAGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39362	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				TTCCTTTCATTCACAGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39363	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				TTCCTTTCATTCACAGTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39364	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AACATGCTCAAACCACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39365	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				AACATGCTCAAACCACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39366	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AACATGCTCAAACCACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39367	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				AACATGCTCAAACCACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39368	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AATACTGTATTCCAGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39369	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				AATACTGTATTCCAGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39370	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AATACTGTATTCCAGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39371	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				AATACTGTATTCCAGAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39372	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AGATGCTGCGGTGGTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39373	hg19	N/A	N/A	fant46062	Enhatls53756	enhancer	E_304				AGATGCTGCGGTGGTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209424				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39374	hg19	N/A	N/A	N/A	Enhatls53756	enhancer	E_304				AGATGCTGCGGTGGTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	209311				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-49824	chr14	54653912	54658550	54187194	54191832	39375	hg19	N/A	enh30902	N/A	Enhatls53756	enhancer	E_304				AGATGCTGCGGTGGTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SAMD4A	direct	Highly Significant	NA					CDKN3	chr14	54396978	54420218	204763				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1781
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39376	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTCAGTCTGGAGTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39377	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				ACTCAGTCTGGAGTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39378	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTCAGTCTGGAGTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39379	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CAAATGATGATAATCGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39380	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				CAAATGATGATAATCGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39381	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CAAATGATGATAATCGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39382	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GGCAGCAATGACTCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39383	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				GGCAGCAATGACTCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39384	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GGCAGCAATGACTCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39385	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTAACACCTGAGTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39386	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				ACTAACACCTGAGTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39387	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTAACACCTGAGTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39388	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CAGGACTCTAAAGTAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39389	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				CAGGACTCTAAAGTAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39390	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CAGGACTCTAAAGTAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39391	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GTGGTTGGCTCCATTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39392	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				GTGGTTGGCTCCATTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39393	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GTGGTTGGCTCCATTAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39394	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GCTGCCTACTAAGGACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39395	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				GCTGCCTACTAAGGACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39396	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GCTGCCTACTAAGGACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39397	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CCTCTGATATCAAACCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39398	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				CCTCTGATATCAAACCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39399	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CCTCTGATATCAAACCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39400	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GGTAAAATGTGGAGAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39401	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				GGTAAAATGTGGAGAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39402	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				GGTAAAATGTGGAGAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39403	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTCAGGTGGCACGGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39404	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				ACTCAGGTGGCACGGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39405	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				ACTCAGGTGGCACGGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39406	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CCATGAGTACTTACTCTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57363				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39407	hg19	N/A	enh3291	fant46363	Enhatls54573	enhancer	E_306				CCATGAGTACTTACTCTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	57155				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50595	chr14	65819522	65829414	65352804	65362696	39408	hg19	N/A	enh3291	N/A	Enhatls54573	enhancer	E_306				CCATGAGTACTTACTCTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PLEKHG3	direct	Highly Significant	NA					FUT8	chr14	65410591	65744121	46345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2552
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39409	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GGAGAAAATAAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39410	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				GGAGAAAATAAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39411	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GGAGAAAATAAAATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39412	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				TTACTACCCCAGGAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39413	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				TTACTACCCCAGGAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39414	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				TTACTACCCCAGGAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39415	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ACTGACACCGGCTGGCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39416	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				ACTGACACCGGCTGGCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39417	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ACTGACACCGGCTGGCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39418	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				TATGATTTCATCTCTTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39419	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				TATGATTTCATCTCTTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39420	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				TATGATTTCATCTCTTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39421	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ACACGCCCAGAACCCCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39422	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				ACACGCCCAGAACCCCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39423	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ACACGCCCAGAACCCCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39424	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ATTGATCTGTTGTCGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39425	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				ATTGATCTGTTGTCGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39426	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				ATTGATCTGTTGTCGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39427	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				CCCTAAAGTCGTAGTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39428	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				CCCTAAAGTCGTAGTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39429	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				CCCTAAAGTCGTAGTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39430	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				CCCTTCAATCAAAAATAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39431	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				CCCTTCAATCAAAAATAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39432	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				CCCTTCAATCAAAAATAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39433	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GATGTTGTAATAGATGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39434	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				GATGTTGTAATAGATGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39435	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GATGTTGTAATAGATGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39436	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GAATATAGCCAGTAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39437	hg19	N/A	enh3313	fant46569	Enhatls54963	enhancer	E_307				GAATATAGCCAGTAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71583951	71586086	71117234	71119369	39438	hg19	N/A	enh3313	N/A	Enhatls54963	enhancer	E_307				GAATATAGCCAGTAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	3640				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39439	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				GGAGGGAAGGAAGAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39440	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				GGAGGGAAGGAAGAAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39441	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				GGAATACAATTTGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39442	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				GGAATACAATTTGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39443	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				ACAGCATAGTTAGGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39444	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				ACAGCATAGTTAGGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39445	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				GATCTGCTGGAGCATCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39446	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				GATCTGCTGGAGCATCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39447	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				ATCACGGCTAAAGTTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39448	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				ATCACGGCTAAAGTTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39449	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				CTAAGAATGCCTAACTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39450	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				CTAAGAATGCCTAACTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39451	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				ACCCACGGCACCCACCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39452	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				ACCCACGGCACCCACCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39453	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				GTAACTTCCAGACGTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39454	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				GTAACTTCCAGACGTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39455	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				GCGGAGACTTTCTGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39456	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				GCGGAGACTTTCTGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39457	hg19	N/A	enh15741	N/A	Enhatls54963	enhancer	E_308				CAAGTTTATGAAGAAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	13167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-50962	chr14	71596508	71600846	71129791	71134129	39458	hg19	N/A	N/A	N/A	Enhatls54963	enhancer	E_308				CAAGTTTATGAAGAAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K9	direct	Highly Significant	NA					PCNX1	chr14	70907458	71115382	17717				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2919
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39459	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39460	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39461	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39462	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39463	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39464	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39465	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39466	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39467	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39468	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39469	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGCCAGCACCCAGATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39470	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39471	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39472	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39473	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39474	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39475	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39476	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39477	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39478	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39479	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39480	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CCTTGGCTGCCAAACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39481	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39482	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39483	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39484	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39485	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39486	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39487	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39488	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39489	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39490	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39491	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCTTGGGGACACGGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39492	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39493	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39494	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39495	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39496	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39497	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39498	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39499	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39500	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39501	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39502	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GCTGACTGATGAGGGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39503	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39504	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39505	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39506	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39507	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39508	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39509	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39510	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39511	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39512	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39513	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCAGACCTAGGTGTGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39514	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39515	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39516	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39517	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39518	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39519	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39520	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39521	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39522	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39523	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39524	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GGATGACCCTGCCAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39525	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39526	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39527	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39528	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39529	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39530	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39531	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39532	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39533	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39534	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39535	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTGCTTCCCAGACAGCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39536	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39537	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39538	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39539	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39540	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39541	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39542	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39543	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39544	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39545	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39546	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCGGGGTTAATGTCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39547	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39548	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39549	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39550	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39551	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39552	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39553	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39554	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39555	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39556	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39557	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCTGGACCCTTTAGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39558	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39559	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39560	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39561	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39562	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39563	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39564	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39565	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39566	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39567	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39568	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CAGTGGACCAACACATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39569	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39570	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39571	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39572	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39573	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39574	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39575	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39576	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39577	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39578	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39579	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TTGGCAGCCCGGCAGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39580	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39581	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39582	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39583	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39584	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39585	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39586	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39587	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39588	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39589	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39590	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TACAGAAGTCGGTGAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39591	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39592	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39593	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39594	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39595	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39596	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39597	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39598	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39599	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39600	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39601	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGTTTTCTGAAAAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39602	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39603	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39604	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39605	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39606	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39607	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39608	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39609	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39610	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39611	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39612	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				ATGACTCCCACTTTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39613	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39614	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39615	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39616	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39617	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39618	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39619	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39620	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39621	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39622	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39623	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGAGGGCAAAGGAATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39624	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39625	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39626	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39627	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39628	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39629	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39630	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39631	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39632	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39633	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39634	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTTCCATCAGTGGGGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39635	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39636	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39637	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39638	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39639	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39640	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39641	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39642	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39643	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39644	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39645	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				TCCCTCGCAACAGGTACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39646	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39647	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39648	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39649	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39650	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39651	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39652	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39653	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39654	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39655	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39656	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GTAGCTCAGGCTATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39657	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39658	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39659	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39660	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39661	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39662	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39663	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39664	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39665	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39666	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39667	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				CTTACCCTCCAGGTCTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39668	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39669	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39670	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39671	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39672	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39673	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39674	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39675	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39676	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39677	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39678	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				AGTTAGAGTTCCAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39679	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39680	hg19	N/A	enh15769	fant46643	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39681	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39682	hg19	N/A	enh15769	fant46644	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39683	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39684	hg19	N/A	enh15769	fant46645	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39685	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39686	hg19	N/A	enh15769	fant46646	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39687	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39688	hg19	N/A	enh15769	fant46647	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51272	chr14	75031729	75043713	74565026	74577010	39689	hg19	N/A	enh15769	N/A	Enhatls55287	enhancer	E_309				GATAAAGTGCCGGCTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					LTBP2	chr14	74498182	74612237	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3229
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39690	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GTTACCACCCCAAAGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39691	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GTTACCACCCCAAAGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39692	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GTTTCTGACAGGTTTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39693	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GTTTCTGACAGGTTTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39694	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				CAATGGTTAAGGATGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39695	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				CAATGGTTAAGGATGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39696	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GTGAAGGAAGAACCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39697	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GTGAAGGAAGAACCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39698	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GACCGGGCATGGATGTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39699	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GACCGGGCATGGATGTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39700	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GCCCTAAAATGTTAGTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39701	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GCCCTAAAATGTTAGTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39702	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GGAGTGATCCTGGCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39703	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GGAGTGATCCTGGCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39704	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				TTCTGGGCGGGCCCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39705	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				TTCTGGGCGGGCCCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39706	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GATCTGTCCAGGAACTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39707	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GATCTGTCCAGGAACTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39708	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GCATAGACGAAGAAGTACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39709	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GCATAGACGAAGAAGTACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39710	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				GGTCACCTAGAACAGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39711	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				GGTCACCTAGAACAGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51360	chr14	75529744	75531168	75063041	75064465	39712	hg19	N/A	N/A	N/A	Enhatls55382	enhancer	E_310				CCTCCAGAATTAAGCTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3317
enhrx-51361	chr14	75529744	75531168	75063041	75064465	39713	hg19	N/A	N/A	N/A	Enhatls55383	enhancer	E_310				CCTCCAGAATTAAGCTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					ACYP1	chr14	75053236	75069483	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3318
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39714	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				TAGCAAATGCTGATAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39715	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				CGTCATGCTTGACTTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39716	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				CCCTAACAATACTACTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39717	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				CATAAAATGTGGGAAATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39718	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				ACAAGTCTCCGACTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39719	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				CAGGCTCTATATGCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39720	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				ATATAAAGGTAACCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-51384	chr14	75632385	75634759	75165682	75168056	39721	hg19	N/A	enh86177	N/A	Enhatls55408	enhancer	E_311				CAGAAGTCAGCATAAAGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	FOS	direct	Highly Significant	NA					TMED10	chr14	75131468	75176612	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3341
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39722	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGACAAACTCTCCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39723	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GAGACAAACTCTCCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39724	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGACAAACTCTCCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39725	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GAGACAAACTCTCCCAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39726	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				AAACATGTCTGGCCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39727	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				AAACATGTCTGGCCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39728	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				AAACATGTCTGGCCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39729	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				AAACATGTCTGGCCAGCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39730	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TGAATGGAAACATCCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39731	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				TGAATGGAAACATCCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39732	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TGAATGGAAACATCCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39733	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				TGAATGGAAACATCCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39734	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GGCTTTTTCACACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39735	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GGCTTTTTCACACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39736	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GGCTTTTTCACACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39737	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GGCTTTTTCACACCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39738	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TCGGGGACGGTGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39739	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				TCGGGGACGGTGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39740	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TCGGGGACGGTGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39741	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				TCGGGGACGGTGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39742	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CTGGGGGTGACTCCTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39743	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				CTGGGGGTGACTCCTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39744	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CTGGGGGTGACTCCTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39745	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				CTGGGGGTGACTCCTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39746	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				ATTGCCCTCAGCGGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39747	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				ATTGCCCTCAGCGGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39748	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				ATTGCCCTCAGCGGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39749	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				ATTGCCCTCAGCGGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39750	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGAGAACGGCCACATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39751	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GAGAGAACGGCCACATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39752	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGAGAACGGCCACATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39753	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GAGAGAACGGCCACATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39754	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TGAGGCTGTCCCGAGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39755	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				TGAGGCTGTCCCGAGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39756	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				TGAGGCTGTCCCGAGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39757	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				TGAGGCTGTCCCGAGTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39758	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGAGTGGCAGCCTCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39759	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GAGAGTGGCAGCCTCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39760	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GAGAGTGGCAGCCTCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39761	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GAGAGTGGCAGCCTCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39762	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GCATCTTCCCCGGCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39763	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GCATCTTCCCCGGCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39764	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GCATCTTCCCCGGCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39765	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GCATCTTCCCCGGCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39766	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CAGAAACGTAAATTCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39767	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				CAGAAACGTAAATTCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39768	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CAGAAACGTAAATTCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39769	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				CAGAAACGTAAATTCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39770	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GGGCACTGCACCACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39771	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				GGGCACTGCACCACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39772	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				GGGCACTGCACCACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39773	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				GGGCACTGCACCACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39774	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CTCTGGGTAAACTGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14971				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39775	hg19	N/A	enh3485	fant47438	Enhatls57218	enhancer	E_312				CTCTGGGTAAACTGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	14794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39776	hg19	N/A	enh3485	N/A	Enhatls57218	enhancer	E_312				CTCTGGGTAAACTGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	12788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53064	chr14	105130075	105135167	104663738	104668830	39777	hg19	N/A	N/A	N/A	Enhatls57218	enhancer	E_312				CTCTGGGTAAACTGTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					INF2	chr14	104681145	104722535	6570				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5021
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39778	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				TCAACAAATCTATCAGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39779	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				TCTGGGATTCTCTGGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39780	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				AGAGCAACTCCACCTTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39781	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				GACCTTGCTGATTTAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39782	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				GTAGCAGTGAGGATGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39783	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				TACCCTATATGGTCTAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39784	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				GCAGGCCTGAGGGCTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39785	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				AATCAGGGCGAGTACATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39786	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				TGTAACACAACTCCTTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39787	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				AGCAGGCTCGAACTCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53157	chr14	105498708	105500745	105032371	105034408	39788	hg19	N/A	enh80937	N/A	Enhatls57315	enhancer	E_313				CATCTTCCATTCTAGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					CDCA4	chr14	105009572	105021083	6337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5114
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39789	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39790	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39791	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39792	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39793	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39794	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39795	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				ACAGGCCCTCAGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39796	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39797	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39798	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39799	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39800	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39801	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39802	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				TTCCAAGGCCAGGTGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39803	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39804	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39805	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39806	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39807	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39808	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39809	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GTGCTGCTAGCCACAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39810	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39811	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39812	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39813	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39814	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39815	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39816	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GAAACCCGACAGGGTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39817	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39818	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39819	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39820	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39821	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39822	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39823	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GTGTAGGGCTGGCCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39824	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39825	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39826	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39827	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39828	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39829	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39830	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GCGGGAGCCCAAATGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39831	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39832	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39833	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39834	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39835	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39836	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39837	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GTGCGCCGGATGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39838	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39839	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39840	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39841	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39842	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39843	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39844	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GGAGGCACAGCATGGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39845	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39846	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39847	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39848	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39849	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39850	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39851	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				ACCCTCCTTCCGCCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39852	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39853	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39854	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39855	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39856	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39857	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39858	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GCCACCTGTGTCTGCTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39859	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39860	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39861	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39862	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39863	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39864	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39865	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GTCGGACTCTGACCTGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39866	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39867	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39868	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39869	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39870	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39871	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39872	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GTGAGAGCATGTTCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-53255	chr14	105958241	105969478	105491904	105503141	39873	hg19	N/A	N/A	N/A	Enhatls57415	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5212
enhrx-53256	chr14	105958241	105969478	105491904	105503141	39874	hg19	N/A	N/A	N/A	Enhatls57416	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5213
enhrx-53257	chr14	105958241	105969478	105491904	105503141	39875	hg19	N/A	N/A	N/A	Enhatls57417	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5214
enhrx-53258	chr14	105958241	105969478	105491904	105503141	39876	hg19	N/A	N/A	N/A	Enhatls57418	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5215
enhrx-53259	chr14	105958241	105969478	105491904	105503141	39877	hg19	N/A	N/A	N/A	Enhatls57419	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5216
enhrx-53260	chr14	105958241	105969478	105491904	105503141	39878	hg19	N/A	N/A	N/A	Enhatls57420	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-53261	chr14	105958241	105969478	105491904	105503141	39879	hg19	N/A	N/A	N/A	Enhatls57421	enhancer	E_314				GCACCGGCAAGACCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GPR132,AKT1"	direct	Highly Significant	NA					TEDC1	chr14	105489854	105499575	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5218
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39880	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				GCATGATTGCAAATTAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39881	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				ACATTGCCTCAAGTAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39882	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				AGATGGTACGAAATGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39883	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				TTTAGTTTCCTGAGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39884	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				GGTGTAGTAAAGCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39885	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				CCCATTATCTACTAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39886	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				CATTTTTCTCTTTGCAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39887	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				CCATCCTGCCTTAATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36697904	36700876	36405703	36408675	39888	hg19	N/A	enh31275	N/A	Enhatls58549	enhancer	E_315				CCGAAGAAAGATCAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	169592				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39889	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TCCGTTGATAAAAACTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39890	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				TCCGTTGATAAAAACTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39891	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TCCGTTGATAAAAACTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39892	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				ATACAGCGTTGCTCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39893	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				ATACAGCGTTGCTCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39894	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				ATACAGCGTTGCTCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39895	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TGTGCTCAAGTGCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39896	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				TGTGCTCAAGTGCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39897	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TGTGCTCAAGTGCTAAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39898	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GGAGGCAGCGTCTTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39899	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				GGAGGCAGCGTCTTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39900	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GGAGGCAGCGTCTTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39901	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				ATTAGTCCAGTGACTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39902	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				ATTAGTCCAGTGACTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39903	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				ATTAGTCCAGTGACTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39904	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TTCACACAGAGAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39905	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				TTCACACAGAGAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39906	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TTCACACAGAGAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39907	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				AATGTGGGTGTCATCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39908	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				AATGTGGGTGTCATCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39909	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				AATGTGGGTGTCATCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39910	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GCAGGGGCACTATGTCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39911	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				GCAGGGGCACTATGTCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39912	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GCAGGGGCACTATGTCTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39913	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				AACCACTTGGCCATGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39914	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				AACCACTTGGCCATGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39915	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				AACCACTTGGCCATGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39916	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GAAATATCCATACATTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39917	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				GAAATATCCATACATTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39918	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				GAAATATCCATACATTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39919	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TATCTCCCTGTGATATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39920	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				TATCTCCCTGTGATATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39921	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				TATCTCCCTGTGATATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39922	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				CTATTGAATTCACATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151494				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39923	hg19	N/A	enh31277	fant47795	Enhatls58549	enhancer	E_316				CTATTGAATTCACATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	151049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54364	chr15	36718683	36725638	36426482	36433437	39924	hg19	N/A	enh31277	N/A	Enhatls58549	enhancer	E_316				CTATTGAATTCACATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEIS2	direct	Highly Significant	NA					CDIN1	chr15	36579625	36810246	145252				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1066
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39925	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39926	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39927	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39928	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39929	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39930	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39931	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				ACTAATACTTGTTGTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39932	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39933	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39934	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39935	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39936	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39937	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39938	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GCTTTCCACAGTCCAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39939	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39940	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39941	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39942	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39943	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39944	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39945	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GTGAATTGTCTTCAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39946	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39947	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39948	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39949	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39950	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39951	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39952	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GAGCAGCAGTCACATCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39953	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39954	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39955	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39956	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39957	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39958	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39959	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				AGTGATAAGAGCACAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39960	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39961	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39962	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39963	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39964	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39965	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39966	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				CATACCTTCTGAGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39967	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39968	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39969	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39970	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39971	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39972	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39973	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GACCAACTAGACCCAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39974	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39975	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39976	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39977	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39978	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39979	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39980	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GCTATGGCATCCAGCCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39981	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39982	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39983	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39984	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39985	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39986	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39987	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GCTTGATTCATGAGTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39988	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39989	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39990	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39991	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39992	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39993	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39994	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				CTACATTTATCCCCTAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39995	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39996	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39997	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39998	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	39999	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40000	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40001	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				TCACTCAATTTGACTATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40002	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40003	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40004	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40005	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40006	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40007	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40008	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				CATATTTATCATTATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40009	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40010	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40011	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40012	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40013	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40014	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40015	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				CTTGTGTGCTTAAACCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40016	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40017	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40018	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40019	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40020	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40021	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40022	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				GCCCTCATCCATCTTGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40023	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40024	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40025	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40026	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40027	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40028	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40029	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				TTGCAAGGTACTGTCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40030	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40031	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40032	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40033	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40034	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40035	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40036	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				TAGAATTTTATGATGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40037	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440989				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40038	hg19	N/A	enh16052	fant47868	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440868				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40039	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40040	hg19	N/A	enh16052	fant47869	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	440265				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40041	hg19	N/A	enh16052	N/A	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	438505				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40042	hg19	N/A	N/A	N/A	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	437015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54441	chr15	39431187	39440319	39138986	39148118	40043	hg19	N/A	enh80966	N/A	Enhatls58634	enhancer	E_318				CTTAAAGAGTTTGAGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SPRED1	direct	Highly Significant	NA					THBS1	chr15	39581078	39599466	432865				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1143
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40044	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40045	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40046	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40047	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40048	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40049	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40050	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				AAGGCCACCAGACTAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40051	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40052	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40053	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40054	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40055	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40056	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40057	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				AGGCTGGGAGAGCTGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40058	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40059	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40060	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40061	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40062	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40063	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40064	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGGTGGAAATGATTCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40065	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40066	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40067	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40068	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40069	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40070	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40071	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				ATGCGCCTGCGAGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40072	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40073	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40074	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40075	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40076	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40077	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40078	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GCACGGCGGCGGCAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40079	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40080	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40081	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40082	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40083	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40084	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40085	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGCTGTAACAAAGAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40086	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40087	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40088	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40089	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40090	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40091	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40092	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GAAGGCCGCGAGCTTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40093	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40094	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40095	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40096	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40097	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40098	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40099	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CCCCAATCTCGCTCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40100	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40101	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40102	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40103	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40104	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40105	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40106	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GAGGGGCCGCCGACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40107	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40108	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40109	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40110	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40111	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40112	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40113	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CTTAGGGGCTCGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40114	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40115	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40116	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40117	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40118	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40119	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40120	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				TGCTGCGACGGCGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40121	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40122	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40123	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40124	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40125	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40126	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40127	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				GGTCGAGGAGGGCCGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40128	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40129	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40130	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40131	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40132	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40133	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40134	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CCGGCAATGAGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40135	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40136	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40137	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40138	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40139	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40140	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40141	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				CAGGACTTGCTGTCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54717	chr15	41229326	41236120	40937128	40943922	40142	hg19	N/A	N/A	N/A	Enhatls58913	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1419
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40143	hg19	N/A	N/A	N/A	Enhatls58914	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40144	hg19	N/A	enh16070	N/A	Enhatls58914	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40145	hg19	N/A	enh16070	N/A	N/A	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40146	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40147	hg19	N/A	enh16070	fant47979	Enhatls58915	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	2451				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54718	chr15	41229326	41236120	40937128	40943922	40148	hg19	N/A	enh16070	N/A	Enhatls58915	enhancer	E_319				TGCCTGTTAGGCGTTGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					DLL4	chr15	40929339	40939073	3191				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1420
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40149	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GAGACGAGATTTCACTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40150	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				GAGACGAGATTTCACTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40151	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GAGACGAGATTTCACTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40152	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				GAGACGAGATTTCACTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40153	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				AATTTCATTCTCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40154	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				AATTTCATTCTCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40155	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				AATTTCATTCTCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40156	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				AATTTCATTCTCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40157	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				ACTACAGTTTAACCTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40158	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				ACTACAGTTTAACCTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40159	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				ACTACAGTTTAACCTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40160	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				ACTACAGTTTAACCTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40161	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				ACGTGGTACAGCTTCTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40162	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				ACGTGGTACAGCTTCTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40163	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				ACGTGGTACAGCTTCTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40164	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				ACGTGGTACAGCTTCTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40165	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCTCTCCTTGCGTCGTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40166	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				GCTCTCCTTGCGTCGTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40167	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCTCTCCTTGCGTCGTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40168	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				GCTCTCCTTGCGTCGTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40169	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TCTCAAGGTGGCCAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40170	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				TCTCAAGGTGGCCAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40171	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TCTCAAGGTGGCCAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40172	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				TCTCAAGGTGGCCAACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40173	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCTGCTCGCCCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40174	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				GCTGCTCGCCCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40175	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCTGCTCGCCCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40176	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				GCTGCTCGCCCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40177	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				CCTTCTCGGCTCACCTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40178	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				CCTTCTCGGCTCACCTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40179	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				CCTTCTCGGCTCACCTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40180	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				CCTTCTCGGCTCACCTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40181	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTGGAACCCCCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40182	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				TTGGAACCCCCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40183	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTGGAACCCCCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40184	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				TTGGAACCCCCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40185	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GTGCAACACACCCAGAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40186	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				GTGCAACACACCCAGAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40187	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GTGCAACACACCCAGAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40188	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				GTGCAACACACCCAGAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40189	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCACTGGGAAGGACCGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40190	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				GCACTGGGAAGGACCGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40191	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				GCACTGGGAAGGACCGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40192	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				GCACTGGGAAGGACCGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40193	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTTCTGCTTGCACCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40194	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				TTTCTGCTTGCACCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40195	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTTCTGCTTGCACCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40196	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				TTTCTGCTTGCACCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40197	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTCTTCGAAAAATAAATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40198	hg19	N/A	enh3545	N/A	Enhatls58966	enhancer	E_320				TTCTTCGAAAAATAAATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	2226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40199	hg19	N/A	enh3545	N/A	N/A	enhancer	E_320				TTCTTCGAAAAATAAATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3336				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54766	chr15	41573294	41578133	41281096	41285935	40200	hg19	N/A	enh3545	N/A	Enhatls58967	enhancer	E_320				TTCTTCGAAAAATAAATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					CHP1	chr15	41231267	41281887	3476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1468
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40201	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40202	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40203	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40204	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40205	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40206	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40207	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40208	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40209	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40210	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40211	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40212	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40213	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				GTGGGAAGAAGTGATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40214	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40215	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40216	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40217	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40218	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40219	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40220	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40221	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40222	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40223	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40224	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40225	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40226	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				GGGGAGGGTTCTGTCTTACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40227	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40228	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40229	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40230	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40231	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40232	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40233	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40234	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40235	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40236	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40237	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40238	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40239	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				TCAAAATGATTGTCTTTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40240	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40241	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40242	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40243	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40244	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40245	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40246	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40247	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40248	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40249	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40250	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40251	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40252	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				AGACATAATCCTTTGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40253	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40254	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40255	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40256	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40257	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40258	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40259	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40260	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40261	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40262	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40263	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40264	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40265	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				GTCCCGGAATGCACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40266	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40267	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40268	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40269	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40270	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40271	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40272	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40273	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40274	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40275	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40276	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40277	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40278	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				GGAATGTGATTACTCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40279	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40280	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40281	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40282	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40283	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40284	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40285	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40286	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40287	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40288	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40289	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40290	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40291	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				GGGGAGAAGGCCTCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40292	hg19	N/A	enh68908	N/A	Enhatls59050	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40293	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40294	hg19	N/A	enh68908	N/A	Enhatls59051	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40295	hg19	N/A	enh68908	N/A	N/A	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40296	hg19	N/A	enh68908	N/A	Enhatls59052	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54845	chr15	41855656	41864560	41563458	41572362	40297	hg19	N/A	N/A	N/A	Enhatls59052	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1547
enhrx-54846	chr15	41855656	41864560	41563458	41572362	40298	hg19	N/A	N/A	N/A	Enhatls59053	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1548
enhrx-54847	chr15	41855656	41864560	41563458	41572362	40299	hg19	N/A	N/A	N/A	Enhatls59054	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1549
enhrx-54848	chr15	41855656	41864560	41563458	41572362	40300	hg19	N/A	N/A	N/A	Enhatls59055	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1550
enhrx-54849	chr15	41855656	41864560	41563458	41572362	40301	hg19	N/A	N/A	N/A	Enhatls59056	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1551
enhrx-54850	chr15	41855656	41864560	41563458	41572362	40302	hg19	N/A	N/A	N/A	Enhatls59057	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1552
enhrx-54851	chr15	41855656	41864560	41563458	41572362	40303	hg19	N/A	N/A	N/A	Enhatls59058	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1553
enhrx-54852	chr15	41855656	41864560	41563458	41572362	40304	hg19	N/A	N/A	N/A	Enhatls59059	enhancer	E_321				AGGATGAGCTGACAGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1554
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40305	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				GCAAGGTGTGGAGGCTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40306	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				GCAAGGTGTGGAGGCTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40307	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				GCAAGGTGTGGAGGCTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40308	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				GCTGGCCACAGAGTGGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40309	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				GCTGGCCACAGAGTGGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40310	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				GCTGGCCACAGAGTGGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40311	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				TGGGTTCAGACAACCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40312	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				TGGGTTCAGACAACCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40313	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				TGGGTTCAGACAACCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40314	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				TTATGTTTCCATGGTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40315	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				TTATGTTTCCATGGTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40316	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				TTATGTTTCCATGGTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40317	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				ATGCATGCACTTAAGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40318	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				ATGCATGCACTTAAGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40319	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				ATGCATGCACTTAAGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40320	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				ACCTAAAAGGGAATATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40321	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				ACCTAAAAGGGAATATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40322	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				ACCTAAAAGGGAATATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40323	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				AGGGTGCGGAATCAGAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40324	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				AGGGTGCGGAATCAGAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40325	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				AGGGTGCGGAATCAGAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40326	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				GCACGCTGCCTTTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40327	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				GCACGCTGCCTTTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40328	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				GCACGCTGCCTTTGGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40329	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				CAGCTGCCTTTGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40330	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				CAGCTGCCTTTGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40331	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				CAGCTGCCTTTGTTAGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40332	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				TGTCCAGTTAGAGGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40333	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				TGTCCAGTTAGAGGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40334	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				TGTCCAGTTAGAGGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54853	chr15	41869078	41873154	41576880	41580956	40335	hg19	N/A	N/A	N/A	Enhatls59060	enhancer	E_322				GCCTGATGAGGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1555
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40336	hg19	N/A	enh16075	N/A	N/A	enhancer	E_322				GCCTGATGAGGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41869078	41873154	41576880	41580956	40337	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_322				GCCTGATGAGGGGGAATTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40338	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				TTTGCTCTTGCTCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40339	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CCTAAGCCACAGACAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40340	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				GGCTCGCTCGAGCTAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40341	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				AGAGGTGAGGATTCGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40342	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				GAGCGGCCTCGGCCAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40343	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				GCCCCAGCTGCGGACAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40344	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CGGTGGCGGCCCGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	indirect	Non Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40345	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CAGCTTTAACGAAAGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40346	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CCCTAGGGCGTAAAAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40347	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CCTGTTTGTCAAGAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40348	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				TCTACAGACAGTAAGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40349	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				CCACGTGGCCGAAGTGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-54854	chr15	41875990	41878290	41583792	41586092	40350	hg19	N/A	enh16075	N/A	Enhatls59061	enhancer	E_323				AACGAAGATGAAGAGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TYRO3	direct	Highly Significant	NA					TYRO3	chr15	41557674	41583589	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1556
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40351	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				ACAAGGGAAAATAAAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40352	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GACATGGTGTGGGAGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40353	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				ACTTGCATCTTTTAATAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40354	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				TGGGTTTCAAAGCTAAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40355	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GGGACCGATCAGCCTGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40356	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				AGAGACGCCGCAGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40357	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				CCTTGGCGCGAGCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40358	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GCAGGCGCTCAGGAGCGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40359	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GAGCACTACCTGAGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40360	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GCTGAGTGACGTACAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40361	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				CGCACGCGGACAAAGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40362	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				CCGGGGGCACAACCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40363	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				GCCGACTGCGAACAAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40364	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				CTGGCCGTCGGGGTTCGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57043	chr15	65820651	65826846	65528313	65534508	40365	hg19	N/A	N/A	N/A	Enhatls61371	enhancer	E_324				CGTAGCTGAATGCCTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					HACD3	chr15	65530417	65578349	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3745
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40366	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				AAGTGGGGAGAGGAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40367	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				AAGTGGGGAGAGGAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40368	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				AAGTGGGGAGAGGAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40369	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				AAGTGGGGAGAGGAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40370	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				TGATCTGCACCCAGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40371	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				TGATCTGCACCCAGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40372	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				TGATCTGCACCCAGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40373	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				TGATCTGCACCCAGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40374	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				CTGGGGAGCTCTGAGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40375	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				CTGGGGAGCTCTGAGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40376	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				CTGGGGAGCTCTGAGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40377	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				CTGGGGAGCTCTGAGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40378	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				TGAGTGGCCTCTATCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40379	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				TGAGTGGCCTCTATCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40380	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				TGAGTGGCCTCTATCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40381	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				TGAGTGGCCTCTATCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40382	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				GTGTCGTTGGGAGAGCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40383	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				GTGTCGTTGGGAGAGCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40384	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				GTGTCGTTGGGAGAGCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40385	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				GTGTCGTTGGGAGAGCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40386	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				AAGAGGGGATTCCAGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40387	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				AAGAGGGGATTCCAGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40388	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				AAGAGGGGATTCCAGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40389	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				AAGAGGGGATTCCAGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40390	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				CCCTGGGGGTCAGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40391	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				CCCTGGGGGTCAGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40392	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				CCCTGGGGGTCAGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40393	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				CCCTGGGGGTCAGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40394	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				CTTTCAATAGCTCCATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40395	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				CTTTCAATAGCTCCATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40396	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				CTTTCAATAGCTCCATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40397	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				CTTTCAATAGCTCCATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40398	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				GGGAGCTTGGCGCTGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40399	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				GGGAGCTTGGCGCTGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40400	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				GGGAGCTTGGCGCTGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40401	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				GGGAGCTTGGCGCTGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40402	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				GACCAGGTCTCCCCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40403	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				GACCAGGTCTCCCCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40404	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				GACCAGGTCTCCCCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40405	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				GACCAGGTCTCCCCCCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57175	chr15	66854545	66860925	66562207	66568587	40406	hg19	N/A	N/A	N/A	Enhatls61510	enhancer	E_328				TCCCAAGCTGGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3877
enhrx-57176	chr15	66854545	66860925	66562207	66568587	40407	hg19	N/A	N/A	N/A	Enhatls61511	enhancer	E_328				TCCCAAGCTGGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3878
enhrx-57177	chr15	66854545	66860925	66562207	66568587	40408	hg19	N/A	N/A	N/A	Enhatls61512	enhancer	E_328				TCCCAAGCTGGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3879
enhrx-57178	chr15	66854545	66860925	66562207	66568587	40409	hg19	N/A	N/A	N/A	Enhatls61513	enhancer	E_328				TCCCAAGCTGGGGGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3880
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40410	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				AGACAGGATCTAGAGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40411	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				AGACAGGATCTAGAGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40412	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				GGAAGTGGGGGCTTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40413	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				GGAAGTGGGGGCTTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40414	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				GACCTAGTGACTCACTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40415	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				GACCTAGTGACTCACTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40416	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				GGCACCCAGTCCTTTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40417	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				GGCACCCAGTCCTTTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40418	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				AGTATGTGGGCCCCTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40419	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				AGTATGTGGGCCCCTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40420	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				CTTCTAGTCAAGCTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40421	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				CTTCTAGTCAAGCTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57180	chr15	66870399	66874836	66578061	66582498	40422	hg19	N/A	N/A	fant48572	N/A	enhancer	E_329				AACACCAGCATGCCTTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	12360				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3882
enhrx-57181	chr15	66870399	66874836	66578061	66582498	40423	hg19	N/A	N/A	N/A	Enhatls61515	enhancer	E_329				AACACCAGCATGCCTTAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					LCTL	chr15	66547178	66565998	16255				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3883
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40424	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				AATGCTTGCTTTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40425	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				AATGCTTGCTTTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40426	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				AATGCTTGCTTTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40427	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				CCATGGTGCTTTGGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40428	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				CCATGGTGCTTTGGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40429	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				CCATGGTGCTTTGGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40430	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GCCCCTCTTGGGAATAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40431	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				GCCCCTCTTGGGAATAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40432	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GCCCCTCTTGGGAATAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40433	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TCAGGGCTCACTTAGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40434	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				TCAGGGCTCACTTAGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40435	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TCAGGGCTCACTTAGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40436	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GCGGGCGTGTCCATGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40437	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				GCGGGCGTGTCCATGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40438	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GCGGGCGTGTCCATGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40439	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TGGGCGGAGGGGCCTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40440	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				TGGGCGGAGGGGCCTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40441	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TGGGCGGAGGGGCCTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40442	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GAGGCCCGAAGCCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40443	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				GAGGCCCGAAGCCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40444	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GAGGCCCGAAGCCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40445	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TTCTAACTCTGGGTATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40446	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				TTCTAACTCTGGGTATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40447	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				TTCTAACTCTGGGTATGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40448	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				AGGAGTTGCTCCTAGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40449	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				AGGAGTTGCTCCTAGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40450	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				AGGAGTTGCTCCTAGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40451	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GACGTAGTAGATCTGTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	11119				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40452	hg19	N/A	enh16255	fant48584	Enhatls61524	enhancer	E_330				GACGTAGTAGATCTGTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20338				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67089783	67098551	66797445	66806213	40453	hg19	N/A	enh16255	N/A	Enhatls61524	enhancer	E_330				GACGTAGTAGATCTGTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD6	chr15	66702235	66782849	20792				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40454	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				GGATAGTGTGGGCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40455	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				TGAGAAGCAGACATGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40456	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				CATTGAAGTTGTCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40457	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				ACCTTCTGACTTACTCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40458	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				TCTACTATGCACAAGATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40459	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				AGGGGTGGCTTTAGTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40460	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				AAGGAGCTGTGTTCCCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40461	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				GCATGGTTAGTGACGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40462	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				CTATGGTTAAGGCAGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57186	chr15	67248282	67249430	66955944	66957092	40463	hg19	N/A	enh31463	N/A	Enhatls61524	enhancer	E_332				GGAAGTACAGCCCTGATAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	104326				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3888
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40464	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TAGAGAATAAAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40465	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TAGAGAATAAAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40466	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TAGAGAATAAAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40467	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TAGAGAATAAAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40468	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GACGGGGATCAGCAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40469	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GACGGGGATCAGCAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40470	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GACGGGGATCAGCAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40471	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GACGGGGATCAGCAAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40472	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				AGAGGACCCGAGCCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40473	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				AGAGGACCCGAGCCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40474	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				AGAGGACCCGAGCCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40475	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				AGAGGACCCGAGCCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40476	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TTGGAGTTGCGGGCCGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40477	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TTGGAGTTGCGGGCCGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40478	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TTGGAGTTGCGGGCCGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40479	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TTGGAGTTGCGGGCCGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40480	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCTGAAGTCGGGCGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40481	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				CCTGAAGTCGGGCGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40482	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCTGAAGTCGGGCGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40483	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				CCTGAAGTCGGGCGGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40484	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CACGTGGGCGACCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40485	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				CACGTGGGCGACCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40486	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CACGTGGGCGACCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40487	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				CACGTGGGCGACCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40488	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGCGCCCTCCCCGGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40489	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GGCGCCCTCCCCGGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40490	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGCGCCCTCCCCGGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40491	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GGCGCCCTCCCCGGAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40492	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGGGAGCCCCGGCGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40493	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GGGGAGCCCCGGCGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40494	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGGGAGCCCCGGCGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40495	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GGGGAGCCCCGGCGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40496	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TCGCTGGCTGGGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40497	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TCGCTGGCTGGGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40498	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TCGCTGGCTGGGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40499	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TCGCTGGCTGGGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40500	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				AGGCGAGCGAAGTTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40501	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				AGGCGAGCGAAGTTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40502	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				AGGCGAGCGAAGTTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40503	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				AGGCGAGCGAAGTTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40504	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGCGGCCGCGAGACTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40505	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GGCGGCCGCGAGACTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40506	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GGCGGCCGCGAGACTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40507	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GGCGGCCGCGAGACTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40508	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TCCCACGGCGAAGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40509	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TCCCACGGCGAAGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40510	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TCCCACGGCGAAGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40511	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TCCCACGGCGAAGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40512	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CGGCGAAGTTGCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40513	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				CGGCGAAGTTGCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40514	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CGGCGAAGTTGCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40515	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				CGGCGAAGTTGCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40516	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TGGGCTCGACGGGACGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40517	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TGGGCTCGACGGGACGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40518	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TGGGCTCGACGGGACGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40519	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TGGGCTCGACGGGACGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40520	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GTCTCAGTTGATATAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40521	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GTCTCAGTTGATATAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40522	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GTCTCAGTTGATATAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40523	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GTCTCAGTTGATATAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40524	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCAAGCCTTACATCAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40525	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				CCAAGCCTTACATCAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40526	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCAAGCCTTACATCAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40527	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				CCAAGCCTTACATCAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40528	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				ATAATGATAGAGAAGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40529	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				ATAATGATAGAGAAGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40530	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				ATAATGATAGAGAAGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40531	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				ATAATGATAGAGAAGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40532	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GAATCAGGTCTCCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40533	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GAATCAGGTCTCCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40534	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GAATCAGGTCTCCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40535	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GAATCAGGTCTCCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40536	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GATAGCTGCCCGTAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40537	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GATAGCTGCCCGTAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40538	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GATAGCTGCCCGTAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40539	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GATAGCTGCCCGTAAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40540	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCAGTAAGCTAGTACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40541	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				CCAGTAAGCTAGTACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40542	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				CCAGTAAGCTAGTACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40543	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				CCAGTAAGCTAGTACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40544	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GCTCTGAAATGACCCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40545	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				GCTCTGAAATGACCCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40546	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				GCTCTGAAATGACCCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40547	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				GCTCTGAAATGACCCAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40548	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TGGCTGTGCTCCTCTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40549	hg19	N/A	N/A	fant48592	Enhatls61525	enhancer	E_333				TGGCTGTGCTCCTCTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40550	hg19	N/A	N/A	N/A	Enhatls61525	enhancer	E_333				TGGCTGTGCTCCTCTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-57188	chr15	67356486	67370793	67064148	67078455	40551	hg19	N/A	enh3672	N/A	Enhatls61525	enhancer	E_333				TGGCTGTGCTCCTCTTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K1	direct	Highly Significant	NA					SMAD3	chr15	67063762	67195173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3890
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40552	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				CTGGGACTGCGGTCTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40553	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GAATGCTCAGGTCATAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40554	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GTGCCATACAGAACAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40555	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				CCCTACTGTGTGCTAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40556	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				TTACATGCTCTCTAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40557	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				TCAGATGTAGATAAAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40558	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				TGTGGTTGCTGCTGTCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40559	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GTTAATGGATGACAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40560	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				CACATCTCATTAATAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40561	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GGTTCTCTGTGCCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40562	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				AATTTTCAGATTCCAAATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40563	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GAGATGTTGGTAACTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40564	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				AAGTCTAGTAGAAAGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40565	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				GGTCCTACCCAGGTGACTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98822900	98832457	98279671	98289228	40566	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_339				TCACAATGAAACTTTGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40567	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				TGGTTTACCACCTATCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40568	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				GGCGCTTGTAAAAAACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40569	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				GTTGGTATGCACACCGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40570	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				CAGGAGATCACTCGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40571	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				GTAAACGGGAAGCCGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40572	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				GCCAGCACCGAGGGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59426	chr15	98835777	98836558	98292548	98293329	40573	hg19	N/A	N/A	N/A	Enhatls63992	enhancer	E_340				GAAACCTGCCCAAAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					ARRDC4	chr15	97960702	97973833	284957				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6128
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40574	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				TATCCTTCCTGTGAAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40575	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				GTCAGTCACCGGGAAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40576	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				TCTGTCGCAGTGAGGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40577	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				GGTGCTTCCTAGCAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40578	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				TCTGTGCAGCCCCATAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40579	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				CCCACGGTGCTGAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40580	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				AGCCTGCTCAGGACGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40581	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				TGGGCTCCTTAATGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40582	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				CATAAGGGGCCACCAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40583	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				CCTGGTTATTTTGAGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40584	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				CTTCCTCTAAAGCTCTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40585	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				GGGTAGCACATCCAGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59459	chr15	99662480	99665976	99122275	99125771	40586	hg19	N/A	enh16463	N/A	Enhatls64027	enhancer	E_341				CGGGTGCTCACAGATAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					SYNM	chr15	99098216	99135593	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6161
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40587	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTTCGGCATCAGATTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40588	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CCTTCGGCATCAGATTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40589	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTTCGGCATCAGATTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40590	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTAATGGCACAGGTGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40591	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CTAATGGCACAGGTGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40592	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTAATGGCACAGGTGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40593	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GTTGTCTGTGAGTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40594	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				GTTGTCTGTGAGTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40595	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GTTGTCTGTGAGTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40596	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTGCATTCCTCTTGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40597	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CCTGCATTCCTCTTGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40598	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTGCATTCCTCTTGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40599	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ACCCTGCGTTCATTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40600	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				ACCCTGCGTTCATTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40601	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ACCCTGCGTTCATTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40602	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ACAATCGTCACATTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40603	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				ACAATCGTCACATTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40604	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ACAATCGTCACATTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40605	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTACTCTGTACCAACCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40606	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CTACTCTGTACCAACCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40607	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTACTCTGTACCAACCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40608	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ATAGCCTGGCGCTAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40609	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				ATAGCCTGGCGCTAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40610	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				ATAGCCTGGCGCTAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40611	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTCGAACAGCAGCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40612	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CTCGAACAGCAGCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40613	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CTCGAACAGCAGCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40614	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GGTGAGGAAGGAGTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40615	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				GGTGAGGAAGGAGTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40616	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GGTGAGGAAGGAGTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40617	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GTGTGATACAAGGAAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40618	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				GTGTGATACAAGGAAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40619	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				GTGTGATACAAGGAAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40620	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CATAAAGTGAAGTGATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40621	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CATAAAGTGAAGTGATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40622	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CATAAAGTGAAGTGATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40623	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTTAAGTGTCCTCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40624	hg19	N/A	enh16464	fant49534	Enhatls64033	enhancer	E_342				CCTTAAGTGTCCTCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99706462	99711654	99166257	99171449	40625	hg19	N/A	enh16464	N/A	Enhatls64033	enhancer	E_342				CCTTAAGTGTCCTCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40626	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				CAGTGCTCCCACATGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40627	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				CCAAGGCCAGTAAGTTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40628	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				CTCAAGAGTTCCCAAATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40629	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				AACCCAAGCTAGCACTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40630	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				AAACTCCTGATGGTAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40631	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				GGTTTTCTTCCGGACCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40632	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				TGTGTTGGCTCTCCAGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40633	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				AGTTAATCACTAAAATGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40634	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				TCTATTAAGTATACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40635	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				GATTTACCTAAGATACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40636	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				AAGTAGCTTATACTGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59465	chr15	99724107	99726976	99183902	99186771	40637	hg19	N/A	enh16465	N/A	Enhatls64034	enhancer	E_343				CACTTCATAGAACTACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6167
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40638	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				CTATCACCAAAGGTTCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40639	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				CTATCACCAAAGGTTCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40640	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				CTATCACCAAAGGTTCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40641	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TATTTAAGCTTTGTCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40642	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				TATTTAAGCTTTGTCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40643	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TATTTAAGCTTTGTCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40644	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GGGTCAGCAAACTATGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40645	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				GGGTCAGCAAACTATGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40646	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GGGTCAGCAAACTATGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40647	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TGGATGATATGTAAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40648	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				TGGATGATATGTAAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40649	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TGGATGATATGTAAACGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40650	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				ATCTGAAATACTTATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40651	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				ATCTGAAATACTTATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40652	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				ATCTGAAATACTTATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40653	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				CATCTTTTATGAACATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40654	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				CATCTTTTATGAACATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40655	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				CATCTTTTATGAACATGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40656	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				ACGGGCAGTCTGGGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40657	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				ACGGGCAGTCTGGGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40658	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				ACGGGCAGTCTGGGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40659	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TTGCCCAGATGAAATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40660	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				TTGCCCAGATGAAATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40661	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TTGCCCAGATGAAATTATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40662	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TTTCTTTAGTGGCTTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40663	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				TTTCTTTAGTGGCTTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40664	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TTTCTTTAGTGGCTTATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40665	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TGGCTGAGATAGCTAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40666	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				TGGCTGAGATAGCTAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40667	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				TGGCTGAGATAGCTAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40668	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GGGAGTCAGGTATTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40669	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				GGGAGTCAGGTATTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40670	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GGGAGTCAGGTATTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40671	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				AATAACAGAAAATGAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40672	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				AATAACAGAAAATGAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40673	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				AATAACAGAAAATGAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40674	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GCTTTGTCAACAAGGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40675	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				GCTTTGTCAACAAGGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40676	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GCTTTGTCAACAAGGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40677	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GTTCCGTCATCTGAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40678	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				GTTCCGTCATCTGAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40679	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				GTTCCGTCATCTGAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40680	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				AATTGAGCCCATTTCAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40681	hg19	N/A	N/A	fant49536	Enhatls64035	enhancer	E_344				AATTGAGCCCATTTCAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99740643	99744469	99200438	99204264	40682	hg19	N/A	N/A	N/A	Enhatls64035	enhancer	E_344				AATTGAGCCCATTTCAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40683	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				GTAGCACCGGAACAGAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40684	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				ATGGAGCATGAGTCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40685	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				GATGGGCACCATAAAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40686	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				TAAAAGATATCCTTTTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40687	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				GTCTTACTACTATATTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40688	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				TACAAAAAAATAAAATTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59466	chr15	99752540	99753170	99212335	99212965	40689	hg19	N/A	enh31644	N/A	Enhatls64035	enhancer	E_345				AGTTTCACAGTGACAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6168
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40690	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				GGTAGATAACAAAGATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40691	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				CACTACTTGCTAAATAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40692	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				TTAGAACGAACGCTCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40693	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				AGGAACAGGTCAGTAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40694	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				CGGAAGCAAGAGTAGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40695	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				GTGAAAGCGCGAGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40696	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				TGGAGCGGAACCCGCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40697	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				CGGCGCTGGAAGCCAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40698	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				TCTGGGGCGTCCCCGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40699	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				GGTCGCGGCGAGTGGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40700	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				TCAGGGTTCTCGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40701	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				CCCAACTGTAACGATCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59473	chr15	99787404	99793989	99247199	99253784	40702	hg19	N/A	N/A	N/A	Enhatls64042	enhancer	E_346				TCAGCTGTGGTAACAAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					TTC23	chr15	99136322	99251223	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6175
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40703	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				GTAAATAACCCAAAGTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	indirect	Non Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40704	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				ATACTCTGGTACGTACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40705	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				AAGACTTACTGTACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40706	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				AACATACTCCCACAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40707	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				ATTAGCTCCAGAAAACGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40708	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				GGGCGGGTACACTGGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40709	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				ACTTACGGACGGTTAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40710	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				AGAGCTATTTTTAGTGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40711	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				CTGTGGTCACTAGCTTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40712	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				GCACAGAACTATGATTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40713	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				TAATCTAAGTAATTACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59478	chr15	99863342	99867166	99323137	99326961	40714	hg19	N/A	N/A	N/A	Enhatls64046	enhancer	E_347				TTAGAGACACTAAGGAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40715	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				ATTCTCATCAACAAAATGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40716	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				CTTTTACAGTATGGTTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40717	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				CTGTGTATGCCAGAGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40718	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				GAAACTTTGATCTGTGAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40719	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				TGGCTGTAGCATCTGTACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40720	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				CATACTGAGCAATTTTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40721	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				TCGTGTACTAACCACTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40722	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				CGAACGTGTACTTCATGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40723	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				GCCAGGTTCACGCTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40724	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				TTAGTTGGCACAGCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40725	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				TCTTTGTATTCAGAAGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59479	chr15	99882483	99884500	99342278	99344295	40726	hg19	N/A	enh3826	N/A	Enhatls64047	enhancer	E_348				GCTTCCTCCAGTGCAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40727	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40728	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40729	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40730	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40731	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40732	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40733	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40734	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40735	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAGTGCTGATCCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40736	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40737	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40738	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40739	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40740	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40741	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40742	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40743	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40744	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CTGAATCTATGAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40745	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40746	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40747	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40748	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40749	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40750	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40751	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40752	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40753	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGTGTCCTGACAAAGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40754	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40755	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40756	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40757	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40758	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40759	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40760	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40761	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40762	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTGACCCTGCAGATCAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40763	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40764	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40765	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40766	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40767	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40768	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40769	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40770	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40771	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AAGGCAGCAGGCGGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40772	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40773	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40774	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40775	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40776	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40777	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40778	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40779	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40780	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGGCCAATAACACAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40781	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40782	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40783	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40784	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40785	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40786	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40787	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40788	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40789	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GAGTGGGAAGGACCGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40790	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40791	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40792	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40793	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40794	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40795	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40796	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40797	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40798	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCACCCACACCCATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40799	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40800	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40801	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40802	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40803	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40804	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40805	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40806	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40807	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATTGGAGCTGGGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40808	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40809	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40810	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40811	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40812	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40813	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40814	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40815	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40816	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACCAAGCTGGCATGAGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40817	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40818	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40819	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40820	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40821	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40822	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40823	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40824	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40825	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCAACTTAGAGGGCAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40826	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40827	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40828	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40829	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40830	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40831	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40832	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40833	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40834	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TGAATGCTGCCAAAGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40835	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40836	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40837	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40838	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40839	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40840	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40841	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40842	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40843	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCAGCCCCATATCCAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40844	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40845	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40846	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40847	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40848	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40849	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40850	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40851	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40852	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCACCTGGCAGGTGGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40853	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40854	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40855	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40856	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40857	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40858	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40859	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40860	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40861	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACAGGACTCCCTGTGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40862	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40863	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40864	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40865	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40866	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40867	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40868	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40869	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40870	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCTGGGACAGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40871	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40872	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40873	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40874	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40875	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40876	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40877	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40878	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40879	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TCCAAGCATGAGTGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40880	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40881	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40882	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40883	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40884	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40885	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40886	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40887	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40888	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCAGATGGAGCCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40889	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40890	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40891	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40892	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40893	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40894	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40895	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40896	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40897	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GCCGGTTCTCAAGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40898	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40899	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40900	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40901	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40902	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40903	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40904	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40905	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40906	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ACGCAGGCCTCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40907	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40908	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40909	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40910	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40911	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40912	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40913	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40914	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40915	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGAGAGACAACACCCTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40916	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40917	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40918	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40919	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40920	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40921	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40922	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40923	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40924	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CCTGGAGCCACATTGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40925	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40926	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40927	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40928	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40929	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40930	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40931	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40932	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40933	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CATTTTAACTGGAATCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40934	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40935	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40936	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40937	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40938	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40939	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40940	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40941	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40942	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTAAACATTAATCAGCAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40943	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40944	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40945	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40946	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40947	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40948	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40949	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40950	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40951	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGAGCCCAATGCTATACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40952	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40953	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40954	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40955	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40956	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40957	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40958	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40959	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40960	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTATGAGCAGTGGCATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40961	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40962	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40963	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40964	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40965	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40966	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40967	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40968	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40969	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GTCCATAGATGCTTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40970	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40971	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40972	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40973	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40974	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40975	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40976	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40977	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40978	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTGCTTTTAATCTTTACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40979	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40980	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40981	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40982	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40983	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40984	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40985	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40986	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40987	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				ATGGCATGTGTGGAGAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40988	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40989	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40990	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40991	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40992	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40993	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40994	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40995	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40996	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				AGTCAACTATGTCAAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40997	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40998	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	40999	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41000	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41001	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41002	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41003	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41004	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41005	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GATTTTGTACCAGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41006	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41007	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41008	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41009	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41010	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41011	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41012	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41013	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41014	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				TTTCCGTGAATGCTGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41015	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41016	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41017	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41018	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41019	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41020	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41021	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41022	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41023	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				GGCTGAGTCTCCTTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41024	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	28492				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41025	hg19	N/A	enh16466	fant49543	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34447				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41026	hg19	N/A	enh16466	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	34785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41027	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	37482				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41028	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	40712				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41029	hg19	N/A	enh16467	fant49544	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42652				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41030	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	42945				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41031	hg19	N/A	enh16467	fant49545	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44366				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99961436	99985614	99421231	99445409	41032	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_349				CGTGATATCACCACATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	44847				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41033	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGCTCCAACAGAAATGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41034	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				AGCTCCAACAGAAATGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41035	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGCTCCAACAGAAATGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41036	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				AGCTCCAACAGAAATGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41037	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGCTCCAACAGAAATGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41038	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GATCTGGCTGGCTTGGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41039	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GATCTGGCTGGCTTGGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41040	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GATCTGGCTGGCTTGGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41041	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GATCTGGCTGGCTTGGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41042	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GATCTGGCTGGCTTGGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41043	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GACCCAGCTAATCCGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41044	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GACCCAGCTAATCCGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41045	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GACCCAGCTAATCCGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41046	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GACCCAGCTAATCCGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41047	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GACCCAGCTAATCCGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41048	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGTTTATCTCCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41049	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GCAGGTTTATCTCCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41050	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGTTTATCTCCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41051	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GCAGGTTTATCTCCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41052	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGTTTATCTCCTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41053	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGCTGACTCACTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41054	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GCAGGCTGACTCACTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41055	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGCTGACTCACTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41056	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GCAGGCTGACTCACTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41057	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GCAGGCTGACTCACTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41058	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				CCGGGCTTCTCCCTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41059	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				CCGGGCTTCTCCCTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41060	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				CCGGGCTTCTCCCTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41061	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				CCGGGCTTCTCCCTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41062	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				CCGGGCTTCTCCCTTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41063	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				TTCCTTCCGTGACACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41064	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				TTCCTTCCGTGACACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41065	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				TTCCTTCCGTGACACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41066	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				TTCCTTCCGTGACACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41067	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				TTCCTTCCGTGACACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41068	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GGCTGGGGAATCTTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41069	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GGCTGGGGAATCTTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41070	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GGCTGGGGAATCTTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41071	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GGCTGGGGAATCTTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41072	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GGCTGGGGAATCTTATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41073	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGGGGAGGCCCCTCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41074	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				AGGGGAGGCCCCTCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41075	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGGGGAGGCCCCTCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41076	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				AGGGGAGGCCCCTCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41077	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				AGGGGAGGCCCCTCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41078	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GAAAGAATGTCCAAACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	59987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41079	hg19	N/A	enh16467	fant49547	Enhatls64051	enhancer	E_350				GAAAGAATGTCCAAACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41080	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GAAAGAATGTCCAAACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	62495				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41081	hg19	N/A	enh16467	fant49548	Enhatls64051	enhancer	E_350				GAAAGAATGTCCAAACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64282				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	99992255	99997314	99452050	99457109	41082	hg19	N/A	enh16467	N/A	Enhatls64051	enhancer	E_350				GAAAGAATGTCCAAACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					LRRC28	chr15	99251361	99390729	64753				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41083	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GCTCCTGCAGCTCAGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41084	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCTCCTGCAGCTCAGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41085	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GCTCCTGCAGCTCAGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41086	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCTCCTGCAGCTCAGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41087	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				TATGGGACTACCGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41088	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TATGGGACTACCGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41089	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				TATGGGACTACCGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41090	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TATGGGACTACCGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41091	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GCAGAGACACTCCATGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41092	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCAGAGACACTCCATGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41093	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GCAGAGACACTCCATGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41094	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCAGAGACACTCCATGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41095	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				TGCACGCTCGGGGAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41096	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCACGCTCGGGGAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41097	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				TGCACGCTCGGGGAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41098	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCACGCTCGGGGAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41099	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GCAGCCAGCCCTCAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41100	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCAGCCAGCCCTCAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41101	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GCAGCCAGCCCTCAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41102	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCAGCCAGCCCTCAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41103	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				CTGTCACGAAACACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41104	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CTGTCACGAAACACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41105	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				CTGTCACGAAACACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41106	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CTGTCACGAAACACACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41107	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				CAGTGGTCTAAGCAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41108	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CAGTGGTCTAAGCAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41109	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				CAGTGGTCTAAGCAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41110	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CAGTGGTCTAAGCAGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41111	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				TGCGTGTGGCACCCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41112	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCGTGTGGCACCCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41113	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				TGCGTGTGGCACCCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41114	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCGTGTGGCACCCTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41115	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				CAAACAGCTTAGGGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41116	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CAAACAGCTTAGGGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41117	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				CAAACAGCTTAGGGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41118	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CAAACAGCTTAGGGAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41119	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GGAAGGAATCTCTCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41120	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GGAAGGAATCTCTCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41121	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GGAAGGAATCTCTCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41122	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GGAAGGAATCTCTCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41123	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				TGCGTTCTCCAGGATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41124	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCGTTCTCCAGGATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41125	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				TGCGTTCTCCAGGATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41126	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				TGCGTTCTCCAGGATGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41127	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				CCAGAGACTGAATTCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41128	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CCAGAGACTGAATTCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41129	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				CCAGAGACTGAATTCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41130	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				CCAGAGACTGAATTCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41131	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GCTCCATGTACAATCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41132	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCTCCATGTACAATCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41133	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GCTCCATGTACAATCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41134	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GCTCCATGTACAATCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41135	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GTTAGGGGATCCCAGAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41136	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GTTAGGGGATCCCAGAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41137	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GTTAGGGGATCCCAGAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41138	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GTTAGGGGATCCCAGAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41139	hg19	N/A	N/A	N/A	Enhatls64051	enhancer	E_351				GGATGTACTGCATTCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	81137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41140	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GGATGTACTGCATTCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	79123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41141	hg19	N/A	enh16468	fant49551	Enhatls64051	enhancer	E_351				GGATGTACTGCATTCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	78611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100024323	100027956	99484118	99487751	41142	hg19	N/A	enh16468	N/A	Enhatls64051	enhancer	E_351				GGATGTACTGCATTCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	75227				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41143	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ATAAATAAATAAAAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41144	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				ATAAATAAATAAAAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41145	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ATAAATAAATAAAAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41146	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGAGCTGCTACAAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41147	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				GGAGCTGCTACAAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41148	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGAGCTGCTACAAGGCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41149	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGGGTGACAACGCTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41150	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				GGGGTGACAACGCTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41151	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGGGTGACAACGCTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41152	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GCTGGTCTTTTTCAAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41153	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				GCTGGTCTTTTTCAAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41154	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GCTGGTCTTTTTCAAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41155	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ACGATGGACTGTTATCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41156	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				ACGATGGACTGTTATCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41157	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ACGATGGACTGTTATCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41158	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CTATTTGTCATAGAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41159	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				CTATTTGTCATAGAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41160	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CTATTTGTCATAGAGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41161	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGTGCCAAACGGATGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41162	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				GGTGCCAAACGGATGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41163	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGTGCCAAACGGATGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41164	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ACGGTAGGTGCTCAGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41165	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				ACGGTAGGTGCTCAGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41166	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				ACGGTAGGTGCTCAGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41167	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CATCTCTTTAGTTCTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41168	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				CATCTCTTTAGTTCTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41169	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CATCTCTTTAGTTCTTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41170	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				TGTTCCAACTGCCTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41171	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				TGTTCCAACTGCCTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41172	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				TGTTCCAACTGCCTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41173	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				TTTCAAATAATATTGAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41174	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				TTTCAAATAATATTGAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41175	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				TTTCAAATAATATTGAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41176	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGTCATATCAGGATCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41177	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				GGTCATATCAGGATCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41178	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				GGTCATATCAGGATCTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41179	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CGGAACATGACGAAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41180	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				CGGAACATGACGAAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41181	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CGGAACATGACGAAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41182	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CCCTATCTGTGGGGTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41183	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				CCCTATCTGTGGGGTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41184	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CCCTATCTGTGGGGTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41185	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CCATCACTGCATCCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56604				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41186	hg19	N/A	enh3827	fant49554	Enhatls64051	enhancer	E_352				CCATCACTGCATCCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	56209				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-59483	chr15	100044677	100050742	99504472	99510537	41187	hg19	N/A	enh3827	N/A	Enhatls64051	enhancer	E_352				CCATCACTGCATCCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	IGF1R	direct	Highly Significant	NA					MEF2A	chr15	99565416	99716488	52915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6185
enhrx-lit705	chr16	3062968	3063916	3012967	3013915	41188	hg19					enhancer	E_354				AGTCCCGCTCGGCTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit706	chr16	3062968	3063916	3012967	3013915	41189	hg19					enhancer	E_354				GGACCAGAAACACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit707	chr16	3062968	3063916	3012967	3013915	41190	hg19					enhancer	E_354				TCTCTGTGTCCAGCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit708	chr16	3062968	3063916	3012967	3013915	41191	hg19					enhancer	E_354				GCTGAGAAGACCTAACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit709	chr16	3062968	3063916	3012967	3013915	41192	hg19					enhancer	E_354				GGGCAGGGCGCAGGACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit710	chr16	3062968	3063916	3012967	3013915	41193	hg19					enhancer	E_354				CGTACACCTTGCACTGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit711	chr16	3062968	3063916	3012967	3013915	41194	hg19					enhancer	E_354				GGGCACCTGTGATGGCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit712	chr16	3062968	3063916	3012967	3013915	41195	hg19					enhancer	E_354				CCCGTATCGTGCTCACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	KCTD5	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41196	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				CTACGGTCACACAGCTAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41197	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				CTACGGTCACACAGCTAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41198	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CTACGGTCACACAGCTAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41199	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				CTACGGTCACACAGCTAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41200	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CTACGGTCACACAGCTAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41201	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				GTCACTTCTTTCTGATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41202	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				GTCACTTCTTTCTGATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41203	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				GTCACTTCTTTCTGATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41204	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				GTCACTTCTTTCTGATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41205	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				GTCACTTCTTTCTGATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41206	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TTAAATTTTGAAAGAACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41207	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TTAAATTTTGAAAGAACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41208	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTAAATTTTGAAAGAACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41209	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TTAAATTTTGAAAGAACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41210	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTAAATTTTGAAAGAACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41211	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TTCCTGCTAGGAGGTTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41212	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TTCCTGCTAGGAGGTTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41213	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTCCTGCTAGGAGGTTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41214	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TTCCTGCTAGGAGGTTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41215	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTCCTGCTAGGAGGTTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41216	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				ACAAGCTTGGATGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41217	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				ACAAGCTTGGATGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41218	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACAAGCTTGGATGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41219	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				ACAAGCTTGGATGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41220	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACAAGCTTGGATGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41221	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				CAGGGACTATGTTGAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41222	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				CAGGGACTATGTTGAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41223	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CAGGGACTATGTTGAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41224	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				CAGGGACTATGTTGAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41225	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CAGGGACTATGTTGAGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41226	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TGAGTCAGCATAGTGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41227	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TGAGTCAGCATAGTGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41228	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TGAGTCAGCATAGTGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41229	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TGAGTCAGCATAGTGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41230	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TGAGTCAGCATAGTGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41231	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TTAAACTCAGGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41232	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TTAAACTCAGGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41233	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTAAACTCAGGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41234	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TTAAACTCAGGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41235	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TTAAACTCAGGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41236	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				ACTTACTAATCACAGGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41237	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				ACTTACTAATCACAGGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41238	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACTTACTAATCACAGGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41239	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				ACTTACTAATCACAGGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41240	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACTTACTAATCACAGGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41241	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				ATCTGATCAGTGCCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41242	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				ATCTGATCAGTGCCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41243	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ATCTGATCAGTGCCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41244	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				ATCTGATCAGTGCCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41245	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ATCTGATCAGTGCCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41246	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TCGCCAGAATGTAAGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41247	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TCGCCAGAATGTAAGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41248	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TCGCCAGAATGTAAGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41249	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TCGCCAGAATGTAAGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41250	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TCGCCAGAATGTAAGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41251	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				TACAACGTAAGGCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41252	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				TACAACGTAAGGCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41253	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TACAACGTAAGGCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41254	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				TACAACGTAAGGCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41255	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				TACAACGTAAGGCCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41256	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				ACAGGGCCTTACACAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41257	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				ACAGGGCCTTACACAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41258	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACAGGGCCTTACACAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41259	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				ACAGGGCCTTACACAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41260	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				ACAGGGCCTTACACAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41261	hg19	N/A	enh31687	N/A	Enhatls65636	enhancer	E_356				CGCTCCCTGGAGGAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46351				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41262	hg19	N/A	N/A	N/A	Enhatls65636	enhancer	E_356				CGCTCCCTGGAGGAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	46142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41263	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CGCTCCCTGGAGGAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41264	hg19	N/A	enh31688	fant49870	Enhatls65636	enhancer	E_356				CGCTCCCTGGAGGAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	43476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61059	chr16	9135984	9144411	9042127	9050554	41265	hg19	N/A	enh31688	N/A	Enhatls65636	enhancer	E_356				CGCTCCCTGGAGGAGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					HAPSTR1	chr16	9091643	9121635	33746				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1354
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41266	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41267	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41268	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41269	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41270	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41271	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41272	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41273	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41274	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41275	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41276	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41277	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41278	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41279	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41280	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41281	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTGATTTAATTTGTTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41282	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41283	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41284	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41285	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41286	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41287	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41288	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41289	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41290	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41291	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41292	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41293	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41294	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41295	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41296	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41297	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGTACAGATTGCATGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41298	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41299	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41300	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41301	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41302	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41303	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41304	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41305	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41306	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41307	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41308	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41309	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41310	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41311	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41312	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41313	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGCTCTGAATAAGTAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41314	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41315	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41316	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41317	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41318	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41319	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41320	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41321	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41322	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41323	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41324	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41325	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41326	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41327	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41328	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41329	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TTCAGAAGTGAAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41330	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41331	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41332	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41333	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41334	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41335	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41336	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41337	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41338	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41339	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41340	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41341	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41342	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41343	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41344	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41345	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GATTGTTCCTATCAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41346	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41347	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41348	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41349	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41350	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41351	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41352	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41353	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41354	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41355	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41356	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41357	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41358	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41359	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41360	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41361	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CGACAGCAGATCCTTGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41362	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41363	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41364	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41365	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41366	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41367	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41368	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41369	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41370	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41371	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41372	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41373	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41374	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41375	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41376	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41377	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATTTCTGTCTGCGTTCTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41378	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41379	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41380	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41381	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41382	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41383	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41384	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41385	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41386	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41387	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41388	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41389	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41390	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41391	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41392	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41393	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CCATGGCGGCTGGAAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41394	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41395	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41396	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41397	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41398	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41399	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41400	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41401	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41402	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41403	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41404	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41405	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41406	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41407	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41408	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41409	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATGTGCCAGTTCAACTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41410	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41411	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41412	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41413	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41414	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41415	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41416	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41417	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41418	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41419	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41420	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41421	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41422	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41423	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41424	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41425	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATACCTCTTGGAATTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41426	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41427	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41428	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41429	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41430	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41431	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41432	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41433	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41434	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41435	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41436	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41437	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41438	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41439	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41440	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41441	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TTCCTCTTGCAGGGAGTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41442	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41443	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41444	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41445	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41446	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41447	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41448	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41449	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41450	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41451	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41452	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41453	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41454	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41455	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41456	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41457	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CATCTTTCCACCATGCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41458	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41459	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41460	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41461	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41462	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41463	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41464	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41465	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41466	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41467	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41468	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41469	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41470	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41471	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41472	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41473	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATGGAATGCGAGGCACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41474	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41475	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41476	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41477	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41478	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41479	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41480	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41481	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41482	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41483	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41484	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41485	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41486	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41487	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41488	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41489	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAAATGTAAGACCCTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41490	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41491	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41492	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41493	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41494	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41495	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41496	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41497	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41498	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41499	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41500	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41501	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41502	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41503	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41504	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41505	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCGTGACATTTTTGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41506	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41507	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41508	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41509	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41510	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41511	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41512	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41513	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41514	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41515	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41516	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41517	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41518	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41519	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41520	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41521	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TAAATCAGGCGACTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41522	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41523	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41524	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41525	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41526	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41527	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41528	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41529	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41530	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41531	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41532	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41533	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41534	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41535	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41536	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41537	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AGAGCTGTGACACACCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41538	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41539	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41540	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41541	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41542	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41543	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41544	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41545	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41546	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41547	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41548	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41549	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41550	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41551	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41552	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41553	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAGACTCGTGCCTTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41554	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41555	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41556	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41557	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41558	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41559	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41560	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41561	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41562	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41563	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41564	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41565	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41566	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41567	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41568	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41569	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCTGGCCTGGGAAAACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41570	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41571	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41572	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41573	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41574	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41575	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41576	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41577	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41578	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41579	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41580	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41581	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41582	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41583	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41584	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41585	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GTTGGAGAAGTGCCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41586	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41587	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41588	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41589	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41590	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41591	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41592	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41593	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41594	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41595	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41596	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41597	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41598	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41599	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41600	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41601	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CAGAGAAATTCAGGGCAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41602	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41603	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41604	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41605	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41606	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41607	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41608	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41609	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41610	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41611	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41612	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41613	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41614	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41615	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41616	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41617	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTTGTCTTGAGGCATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41618	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41619	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41620	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41621	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41622	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41623	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41624	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41625	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41626	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41627	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41628	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41629	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41630	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41631	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41632	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41633	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ATTGGCAGCTGGCACCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41634	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41635	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41636	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41637	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41638	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41639	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41640	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41641	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41642	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41643	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41644	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41645	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41646	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41647	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41648	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41649	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				ACCAAATTCAGTCCACAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41650	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41651	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41652	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41653	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41654	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41655	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41656	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41657	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41658	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41659	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41660	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41661	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41662	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41663	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41664	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41665	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				AAAAAACTCTCCCTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41666	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41667	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41668	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41669	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41670	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41671	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41672	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41673	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41674	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41675	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41676	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41677	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41678	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41679	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41680	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41681	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				GCGGGCTCCCAACTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41682	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41683	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41684	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41685	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41686	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41687	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41688	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41689	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41690	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41691	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41692	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41693	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41694	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41695	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41696	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41697	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				TCGTGCCCTCAGCTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41698	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3785				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41699	hg19	N/A	enh81089	fant49928	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	3415				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41700	hg19	N/A	enh81089	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	1464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41701	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	974				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41702	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41703	hg19	N/A	enh3878	fant49929	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41704	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41705	hg19	N/A	enh3878	fant49930	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41706	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41707	hg19	N/A	enh3878	fant49931	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41708	hg19	N/A	enh3878	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61119	chr16	10955359	10975062	10861502	10881205	41709	hg19	N/A	N/A	N/A	Enhatls65699	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1414
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41710	hg19	N/A	N/A	N/A	Enhatls65700	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41711	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41712	hg19	N/A	enh3879	fant49932	Enhatls65700	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-61120	chr16	10955359	10975062	10861502	10881205	41713	hg19	N/A	enh3879	N/A	Enhatls65700	enhancer	E_358				CTGACAGGTAGGACCCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRIN2A	direct	Highly Significant	NA					CIITA	chr16	10866221	10936394	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1415
enhrx-66798	chr17	882521	883353	979281	980113	41714	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				GCACAGGAAGGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41715	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				ACTTCGTGCGGGACATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41716	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				CGGCGGAGCCCGAGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41717	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				CCGCAGGCGCCCGTAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41718	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				GAGAAGCTGGTGACGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41719	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				GCCGCGCGGACCGTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41720	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				CGTGGGCGGCCCTACTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41721	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				GCGTGGCGAGGGCAGCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41722	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				CGCCGGCCGCAAACGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41723	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				AGCAGTCACCCCGCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41724	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				GAGGAGAGAAAATGCGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41725	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				TGAAGAGCTCCGCGGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41726	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				CGGGTCCTATAAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-66798	chr17	882521	883353	979281	980113	41727	hg19	N/A	N/A	N/A	Enhatls71717	enhancer	E_361				AAGCTGTTCTAAGGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					NXN	chr17	799309	979776	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	67
enhrx-lit713	chr17	883513	883768	980273	980528	41728	hg19					enhancer	E_362				GCACAGGAAGGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit714	chr17	883513	883768	980273	980528	41729	hg19					enhancer	E_362				ACTTCGTGCGGGACATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit715	chr17	883513	883768	980273	980528	41730	hg19					enhancer	E_362				CGGCGGAGCCCGAGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit716	chr17	883513	883768	980273	980528	41731	hg19					enhancer	E_362				CCGCAGGCGCCCGTAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit717	chr17	883513	883768	980273	980528	41732	hg19					enhancer	E_362				GAGAAGCTGGTGACGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit718	chr17	883513	883768	980273	980528	41733	hg19					enhancer	E_362				GCCGCGCGGACCGTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit719	chr17	883513	883768	980273	980528	41734	hg19					enhancer	E_362				CGTGGGCGGCCCTACTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit720	chr17	883513	883768	980273	980528	41735	hg19					enhancer	E_362				GCGTGGCGAGGGCAGCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit721	chr17	883513	883768	980273	980528	41736	hg19					enhancer	E_362				CGCCGGCCGCAAACGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit722	chr17	883513	883768	980273	980528	41737	hg19					enhancer	E_362				AGCAGTCACCCCGCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit723	chr17	883513	883768	980273	980528	41738	hg19					enhancer	E_362				GAGGAGAGAAAATGCGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit724	chr17	883513	883768	980273	980528	41739	hg19					enhancer	E_362				TGAAGAGCTCCGCGGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit725	chr17	883513	883768	980273	980528	41740	hg19					enhancer	E_362				CGGGTCCTATAAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit726	chr17	883513	883768	980273	980528	41741	hg19					enhancer	E_362				AAGCTGTTCTAAGGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-66809	chr17	932867	934494	1029627	1031254	41742	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				GATCCTTTGGGTACCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41743	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				GATCCTTTGGGTACCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41744	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				TCCTCTCCCCCAGAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41745	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				TCCTCTCCCCCAGAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41746	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				GGTTCATTAAAGGCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41747	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				GGTTCATTAAAGGCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41748	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				GTGCCTGGTACTGCCCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41749	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				GTGCCTGGTACTGCCCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41750	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				TATCCTCAGCCACATTAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41751	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				TATCCTCAGCCACATTAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41752	hg19	N/A	enh62576	fant51580	Enhatls71731	enhancer	E_363				CTTCCCACCTCACTGTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66809	chr17	932867	934494	1029627	1031254	41753	hg19	N/A	enh62576	N/A	Enhatls71731	enhancer	E_363				CTTCCCACCTCACTGTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	78
enhrx-66810	chr17	941403	944877	1038163	1041637	41754	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CCTGGTTCTCCTTGGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41755	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CCTGGTTCTCCTTGGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41756	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTCTAGACCTGCCTTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41757	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTCTAGACCTGCCTTGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41758	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				AAATGTGCCCGAAACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41759	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				AAATGTGCCCGAAACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41760	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CTGGGGAACTGGCACAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41761	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CTGGGGAACTGGCACAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41762	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTGCATGTCAGGCCCCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41763	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTGCATGTCAGGCCCCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41764	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTCCCACGACAGGGAGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41765	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTCCCACGACAGGGAGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41766	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				ACGGGAGAGATGGAACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41767	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				ACGGGAGAGATGGAACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41768	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTCAGTGTGGCCCACGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41769	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTCAGTGTGGCCCACGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41770	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTCCTGCGCGTGCGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41771	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTCCTGCGCGTGCGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41772	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				AATGGGGACAAGACACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41773	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				AATGGGGACAAGACACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41774	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CGTGGGGCCGGAGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41775	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CGTGGGGCCGGAGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41776	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CTGGTGTGGTCGGAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41777	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CTGGTGTGGTCGGAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41778	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CTGAACCAACCTCATAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41779	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CTGAACCAACCTCATAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41780	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				ATGCTGCCTCGGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41781	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				ATGCTGCCTCGGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41782	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				GTACGTGGTTTGCCCTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41783	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				GTACGTGGTTTGCCCTAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41784	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				CCTGTCAGATGGGCTGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41785	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				CCTGTCAGATGGGCTGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41786	hg19	N/A	N/A	N/A	Enhatls71732	enhancer	E_364				TCTGTTCTCCCAACTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66810	chr17	941403	944877	1038163	1041637	41787	hg19	N/A	enh16919	N/A	Enhatls71732	enhancer	E_364				TCTGTTCTCCCAACTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	79
enhrx-66814	chr17	960977	965486	1057737	1062246	41788	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41789	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41790	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41791	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41792	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41793	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				TCACTTTGTCACTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41794	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41795	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41796	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41797	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41798	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41799	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GTGTGGTACATGTGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41800	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41801	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41802	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41803	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41804	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41805	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				ACTGGACAGGGATATACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41806	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41807	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41808	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41809	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41810	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41811	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GTGTTGACTGTTGACTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41812	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41813	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41814	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41815	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41816	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41817	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GCAAGCCTCCCAGGGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41818	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41819	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41820	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41821	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41822	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41823	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				TGCTCCTGGGCGGGCACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41824	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41825	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41826	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41827	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41828	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41829	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				CCTAGGACAGAGGGTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41830	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41831	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41832	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41833	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41834	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41835	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				AAGATCACCATTACAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41836	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41837	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41838	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41839	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41840	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41841	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				AGTTGAAAGGATCCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66814	chr17	960977	965486	1057737	1062246	41842	hg19	N/A	N/A	N/A	Enhatls71736	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	83
enhrx-66815	chr17	960977	965486	1057737	1062246	41843	hg19	N/A	N/A	N/A	Enhatls71737	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-66816	chr17	960977	965486	1057737	1062246	41844	hg19	N/A	N/A	N/A	Enhatls71738	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41845	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41846	hg19	N/A	enh32039	fant51582	Enhatls71738	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66816	chr17	960977	965486	1057737	1062246	41847	hg19	N/A	enh32039	N/A	Enhatls71738	enhancer	E_365				GCCTGGGCAACAGAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					ABR	chr17	1003518	1229738	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41848	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				TCTAGTTAGCTGCTGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41849	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				CCACTTAGTGAATCCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41850	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				TTGGGGGACAAGAATGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41851	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				GCAGGATTGCTTTCATTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41852	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				GCATGATTACTTCACGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41853	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				GCTTACCCTGATTTATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41854	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				ATCACCCTGTGGAAAACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41855	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				CTGTGTGTATCAGAAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66834	chr17	1325961	1329594	1422667	1426300	41856	hg19	N/A	N/A	N/A	Enhatls71761	enhancer	E_367				ATGGTAATTAAGACTAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	103
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41857	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGAAGTCACCACATACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41858	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GGAAGTCACCACATACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41859	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGAAGTCACCACATACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41860	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CCAAACCCGGCTCTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41861	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				CCAAACCCGGCTCTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41862	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CCAAACCCGGCTCTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41863	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GCGGGGGCATCACTTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41864	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GCGGGGGCATCACTTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41865	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GCGGGGGCATCACTTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41866	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				AGCCGCGGACCGAGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41867	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				AGCCGCGGACCGAGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41868	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				AGCCGCGGACCGAGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41869	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TGAGAGCGAGCCCGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41870	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				TGAGAGCGAGCCCGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41871	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TGAGAGCGAGCCCGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41872	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GAGCGGACCCTCGGGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41873	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GAGCGGACCCTCGGGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41874	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GAGCGGACCCTCGGGGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41875	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GTCAGTCCCTCACCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41876	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GTCAGTCCCTCACCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41877	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GTCAGTCCCTCACCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41878	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGACTCGAGCACCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41879	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GGACTCGAGCACCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41880	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGACTCGAGCACCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41881	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGCACCCCAGCGTTTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41882	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GGCACCCCAGCGTTTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41883	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGCACCCCAGCGTTTAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41884	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGAGCCGGTCCGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41885	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GGAGCCGGTCCGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41886	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGAGCCGGTCCGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41887	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				AGCAGCGCCCGAAATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41888	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				AGCAGCGCCCGAAATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41889	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				AGCAGCGCCCGAAATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41890	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				ATGACGCGCTCCCTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41891	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				ATGACGCGCTCCCTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41892	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				ATGACGCGCTCCCTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41893	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CATGCGCAGTGCGCGCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41894	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				CATGCGCAGTGCGCGCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41895	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CATGCGCAGTGCGCGCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41896	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGTCTAGGGCCCGAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41897	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GGTCTAGGGCCCGAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41898	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GGTCTAGGGCCCGAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41899	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TGGGGCCTGAGTTCTCGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41900	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				TGGGGCCTGAGTTCTCGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41901	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TGGGGCCTGAGTTCTCGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41902	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GATCTCGGCTCACTGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41903	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GATCTCGGCTCACTGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41904	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GATCTCGGCTCACTGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41905	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CAAAAAACAGCCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41906	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				CAAAAAACAGCCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41907	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CAAAAAACAGCCGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41908	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GCTAGAGGAACGAGCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41909	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				GCTAGAGGAACGAGCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41910	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				GCTAGAGGAACGAGCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41911	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CTTTGCACCCGCAGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41912	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				CTTTGCACCCGCAGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41913	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				CTTTGCACCCGCAGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41914	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TCTGTGAGTTCGAGGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41915	hg19	N/A	N/A	fant51604	Enhatls71762	enhancer	E_368				TCTGTGAGTTCGAGGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66835	chr17	1357754	1360999	1454460	1457705	41916	hg19	N/A	N/A	N/A	Enhatls71762	enhancer	E_368				TCTGTGAGTTCGAGGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					CRK	chr17	1420688	1456232	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	104
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41917	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GGTTACGTGTCCGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41918	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GGTTACGTGTCCGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41919	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GGTTACGTGTCCGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41920	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				AAAGCCCCGAAGCTAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41921	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				AAAGCCCCGAAGCTAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41922	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				AAAGCCCCGAAGCTAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41923	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GGACACGTTCCATTCAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41924	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GGACACGTTCCATTCAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41925	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GGACACGTTCCATTCAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41926	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GTGGGCCTCTCCCACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41927	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GTGGGCCTCTCCCACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41928	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GTGGGCCTCTCCCACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41929	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GCTGTATCTGAAACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41930	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GCTGTATCTGAAACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41931	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GCTGTATCTGAAACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41932	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				AGGGTGCGGGCGAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41933	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				AGGGTGCGGGCGAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41934	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				AGGGTGCGGGCGAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41935	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				TCTCCCCGCTCCCGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41936	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				TCTCCCCGCTCCCGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41937	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				TCTCCCCGCTCCCGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41938	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GAGGAAGTTGGGGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41939	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GAGGAAGTTGGGGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41940	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GAGGAAGTTGGGGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41941	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				GTGAGCCTCGCTGGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41942	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				GTGAGCCTCGCTGGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41943	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				GTGAGCCTCGCTGGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66932	chr17	1653839	1659138	1750545	1755844	41944	hg19	N/A	N/A	N/A	Enhatls71871	enhancer	E_370				CACACTGTTAAAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	201
enhrx-66933	chr17	1653839	1659138	1750545	1755844	41945	hg19	N/A	N/A	N/A	Enhatls71872	enhancer	E_370				CACACTGTTAAAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	202
enhrx-66934	chr17	1653839	1659138	1750545	1755844	41946	hg19	N/A	N/A	N/A	Enhatls71873	enhancer	E_370				CACACTGTTAAAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF2	chr17	1742835	1755265	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	203
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41947	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				CGCCGAGGCCAGCGGTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41948	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				CGCCGAGGCCAGCGGTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41949	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				CGCCGAGGCCAGCGGTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41950	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				CGCCGAGGCCAGCGGTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41951	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TGGCTACGTGAGTCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41952	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				TGGCTACGTGAGTCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41953	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TGGCTACGTGAGTCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41954	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				TGGCTACGTGAGTCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41955	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCTGCCAGTGCTGGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41956	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GCTGCCAGTGCTGGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41957	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCTGCCAGTGCTGGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41958	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GCTGCCAGTGCTGGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41959	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TCCAACCCCACGGAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41960	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				TCCAACCCCACGGAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41961	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TCCAACCCCACGGAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41962	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				TCCAACCCCACGGAACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41963	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				AAGCTGAATGAGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41964	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				AAGCTGAATGAGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41965	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				AAGCTGAATGAGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41966	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				AAGCTGAATGAGTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41967	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GGTCCTCTCTGGCCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41968	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GGTCCTCTCTGGCCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41969	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GGTCCTCTCTGGCCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41970	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GGTCCTCTCTGGCCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41971	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GTGGGCCTCGGAGATAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41972	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GTGGGCCTCGGAGATAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41973	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GTGGGCCTCGGAGATAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41974	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GTGGGCCTCGGAGATAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41975	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GGCTGAAGGCTGTGCGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41976	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GGCTGAAGGCTGTGCGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41977	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GGCTGAAGGCTGTGCGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41978	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GGCTGAAGGCTGTGCGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41979	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				AGTTGATCCGCCTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41980	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				AGTTGATCCGCCTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41981	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				AGTTGATCCGCCTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41982	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				AGTTGATCCGCCTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41983	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCTCTCGTCCTAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41984	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GCTCTCGTCCTAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41985	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCTCTCGTCCTAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41986	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GCTCTCGTCCTAGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41987	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TGGGCTGAGCAGGCGACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41988	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				TGGGCTGAGCAGGCGACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41989	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				TGGGCTGAGCAGGCGACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41990	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				TGGGCTGAGCAGGCGACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41991	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCAGTGAGAGGGCAAGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41992	hg19	N/A	N/A	fant51617	Enhatls71874	enhancer	E_371				GCAGTGAGAGGGCAAGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41993	hg19	N/A	N/A	N/A	Enhatls71874	enhancer	E_371				GCAGTGAGAGGGCAAGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66935	chr17	1665369	1667524	1762075	1764230	41994	hg19	N/A	enh109741	N/A	Enhatls71874	enhancer	E_371				GCAGTGAGAGGGCAAGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					SERPINF1	chr17	1762028	1777565	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	204
enhrx-66962	chr17	1859264	1863744	1955970	1960450	41995	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				GAGGAATGAAGTTATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	41996	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				GCTTCACACTCATGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	41997	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				AAGTTTTGTGATACCGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	41998	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				AATTGGACTAGTAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	41999	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				GCTGGCAGCAGCGTGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	42000	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				GCAAGATTTCAGGCTTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	42001	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				GCAGGTGGTAAGTCAGTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	42002	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				CAAAAGGGAAAAGACGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	42003	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				CCATTGTCAGGTGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66962	chr17	1859264	1863744	1955970	1960450	42004	hg19	N/A	enh44366	N/A	Enhatls71906	enhancer	E_373				CATAGACTGCCCAGAGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					RTN4RL1	chr17	1934676	2025334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	231
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42005	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				ACAAGCTCATTGGCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42006	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				TAGGGGTTCCTGGAAGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42007	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				CCAGGGCTCGGCGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42008	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				GCCGGCGGCTGAGTCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42009	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				ACGCGGAGCAGAAGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42010	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				ACAGTAACAATCGAAAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42011	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				GGGCTGACGTCAGGGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42012	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				CCCTAGGGACCCGGACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42013	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				CCCTGAGGGACGGGGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42014	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				ACTGTTACTGAGGGCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42015	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				TGCCGGCGCGCTGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42016	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				GCCTGGTCGCGAGCGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42017	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				GGCACTTCCGGCGGGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-66970	chr17	1951957	1954051	2048663	2050757	42018	hg19	N/A	N/A	N/A	Enhatls71912	enhancer	E_374				GAGGACAGCTCCGCTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRK	direct	Highly Significant	NA					DPH1	chr17	2030136	2043898	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	239
enhrx-67649	chr17	6655393	6656573	6752074	6753254	42019	hg19	N/A	N/A	fant51771	N/A	enhancer	E_376				CTGCTTAGTTGGCATATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	918
enhrx-67650	chr17	6655393	6656573	6752074	6753254	42020	hg19	N/A	N/A	fant51772	N/A	enhancer	E_376				CTGCTTAGTTGGCATATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	919
enhrx-67649	chr17	6655393	6656573	6752074	6753254	42021	hg19	N/A	N/A	fant51771	N/A	enhancer	E_376				CTGGCTGGGCAGCAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	918
enhrx-67650	chr17	6655393	6656573	6752074	6753254	42022	hg19	N/A	N/A	fant51772	N/A	enhancer	E_376				CTGGCTGGGCAGCAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	919
enhrx-67649	chr17	6655393	6656573	6752074	6753254	42023	hg19	N/A	N/A	fant51771	N/A	enhancer	E_376				GCAATTGCACACACTTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	918
enhrx-67650	chr17	6655393	6656573	6752074	6753254	42024	hg19	N/A	N/A	fant51772	N/A	enhancer	E_376				GCAATTGCACACACTTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					XAF1	chr17	6755564	6775647	2137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	919
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42025	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				CAGAGATTCTTCCAGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42026	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				GCCCTGAGAGCAGATGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42027	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				ACGTGGGTGTATGCCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42028	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				CCCAGGTTCTGGCGGAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42029	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				TCGGCTAGCTCCTAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42030	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				AGCGGGGTCGTAGGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42031	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				GGGACTTTGGTCCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42032	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				TCTTCAGGATCCAAGTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42033	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				CAGCTCCACTTACCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42034	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				TGCTGCGACAGAATTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42035	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				TCACAAGATCCAGCTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42036	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				GGGGGAGCCTTTGAACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67884	chr17	7530070	7532118	7626752	7628800	42037	hg19	N/A	N/A	N/A	Enhatls72865	enhancer	E_377				AGGGTCTTAAGGCTTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					SHBG	chr17	7614063	7633382	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1153
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42038	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42039	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42040	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42041	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42042	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42043	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				GGTAAAGTACTTGGAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42044	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42045	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42046	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42047	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42048	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42049	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				TGGGATTCTTCCTCAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42050	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42051	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42052	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42053	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42054	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42055	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				TGCCGGAATCAAGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42056	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42057	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42058	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42059	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42060	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42061	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				AGGGACTCCAGGAAAGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42062	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42063	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42064	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42065	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42066	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42067	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				GACAAGAGGCGCCCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42068	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42069	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42070	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42071	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42072	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42073	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				CTGCGGGAGTCACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42074	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42075	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42076	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42077	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42078	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42079	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				GCGGACTTATGACAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42080	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42081	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42082	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42083	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42084	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42085	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				CGCGCTGGGTGCACATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42086	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42087	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42088	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42089	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42090	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42091	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				TCGTCAGTGAGACCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67905	chr17	7643452	7646822	7740134	7743504	42092	hg19	N/A	N/A	N/A	Enhatls72888	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1174
enhrx-67906	chr17	7643452	7646822	7740134	7743504	42093	hg19	N/A	N/A	N/A	Enhatls72889	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1175
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42094	hg19	N/A	N/A	N/A	Enhatls72890	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42095	hg19	N/A	enh16960	N/A	Enhatls72890	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42096	hg19	N/A	enh16960	N/A	N/A	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67907	chr17	7643452	7646822	7740134	7743504	42097	hg19	N/A	enh16960	N/A	Enhatls72891	enhancer	E_378				ACCTATGTCGGTGAGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1176
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42098	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42099	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42100	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42101	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42102	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42103	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42104	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				TACAGTAAGAATGAATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42105	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42106	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42107	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42108	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42109	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42110	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42111	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				CTGTTTATGGAAGCACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42112	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42113	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42114	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42115	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42116	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42117	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42118	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				TACATTATTAAGTGACATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42119	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42120	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42121	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42122	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42123	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42124	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42125	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				CCAGCGTCTCCATGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42126	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42127	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42128	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42129	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42130	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42131	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42132	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				ACAGTGTGCAATTAAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42133	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42134	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42135	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42136	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42137	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42138	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42139	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				TCTGCAGGTAGTTGCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42140	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42141	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42142	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42143	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42144	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42145	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42146	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				ATGATGTATCAATGCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42147	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42148	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42149	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42150	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42151	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42152	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42153	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				TTGCCAGCTCTTGAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42154	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42155	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42156	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42157	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42158	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42159	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42160	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				TGGGGCATCCAGATCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42161	hg19	N/A	enh81173	N/A	N/A	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42162	hg19	N/A	enh81173	N/A	Enhatls72900	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67916	chr17	7674502	7680229	7771184	7776911	42163	hg19	N/A	N/A	N/A	Enhatls72900	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1185
enhrx-67917	chr17	7674502	7680229	7771184	7776911	42164	hg19	N/A	N/A	N/A	Enhatls72901	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1186
enhrx-67918	chr17	7674502	7680229	7771184	7776911	42165	hg19	N/A	N/A	N/A	Enhatls72902	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1187
enhrx-67919	chr17	7674502	7680229	7771184	7776911	42166	hg19	N/A	N/A	N/A	Enhatls72903	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1188
enhrx-67920	chr17	7674502	7680229	7771184	7776911	42167	hg19	N/A	N/A	N/A	Enhatls72904	enhancer	E_379				CATTCATCGCTCTTCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1189
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42168	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42169	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42170	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42171	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42172	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42173	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42174	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42175	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42176	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42177	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42178	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42179	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42180	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42181	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42182	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42183	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42184	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42185	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42186	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42187	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42188	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				TGATCACGCTAGTGATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42189	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42190	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42191	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42192	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42193	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42194	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42195	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42196	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42197	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42198	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42199	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42200	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42201	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42202	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42203	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42204	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42205	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42206	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42207	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42208	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42209	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GACAGGAACGCGTCAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42210	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42211	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42212	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42213	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42214	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42215	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42216	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42217	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42218	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42219	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42220	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42221	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42222	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42223	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42224	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42225	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42226	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42227	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42228	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42229	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42230	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GTGCACGCGGAGACAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42231	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42232	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42233	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42234	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42235	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42236	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42237	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42238	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42239	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42240	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42241	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42242	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42243	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42244	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42245	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42246	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42247	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42248	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42249	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42250	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42251	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				CAGTGACACATAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42252	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42253	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42254	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42255	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42256	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42257	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42258	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42259	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42260	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42261	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42262	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42263	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42264	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42265	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42266	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42267	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42268	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42269	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42270	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42271	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42272	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				CACAGCGGAGCCTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42273	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42274	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42275	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42276	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42277	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42278	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42279	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42280	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42281	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42282	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42283	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42284	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42285	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42286	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42287	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42288	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42289	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42290	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42291	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42292	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42293	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GCAGGGAGCGGGTTGCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42294	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42295	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42296	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42297	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42298	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42299	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42300	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42301	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42302	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42303	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42304	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42305	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42306	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42307	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42308	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42309	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42310	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42311	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42312	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42313	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42314	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GCGCACGCAAACTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42315	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42316	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42317	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42318	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42319	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42320	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42321	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42322	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42323	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42324	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42325	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42326	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42327	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42328	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42329	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42330	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42331	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42332	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42333	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42334	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42335	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				CTCTCTCTGGGCTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42336	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42337	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42338	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42339	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42340	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42341	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42342	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42343	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42344	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42345	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42346	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42347	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42348	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42349	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42350	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42351	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42352	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42353	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42354	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42355	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42356	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GTCCAGGGCCCGGATGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42357	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42358	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42359	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42360	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42361	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42362	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42363	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42364	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42365	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42366	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42367	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42368	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42369	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42370	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42371	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42372	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42373	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42374	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42375	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42376	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42377	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GGTTAATTCCGCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42378	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42379	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42380	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42381	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42382	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42383	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42384	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42385	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42386	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42387	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42388	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42389	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42390	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42391	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42392	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42393	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42394	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42395	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42396	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42397	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42398	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				ACTCCTCGAAGACAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42399	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42400	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42401	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42402	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42403	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42404	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42405	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42406	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42407	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42408	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42409	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42410	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42411	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42412	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42413	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42414	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42415	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42416	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42417	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42418	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42419	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				CCGGTGTCTATACTAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42420	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42421	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42422	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42423	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42424	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42425	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42426	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42427	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42428	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42429	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42430	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42431	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42432	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42433	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42434	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42435	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42436	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42437	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42438	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42439	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42440	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GAGAGTGGAGCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42441	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42442	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42443	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42444	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42445	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42446	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42447	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42448	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42449	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42450	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42451	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42452	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42453	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42454	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42455	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42456	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42457	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42458	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42459	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42460	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42461	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				CAACTCCTCAGCCCACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42462	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42463	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42464	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42465	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42466	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42467	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42468	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42469	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42470	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42471	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42472	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42473	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42474	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42475	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42476	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42477	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42478	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42479	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42480	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42481	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42482	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				TGTGTGTGTTCAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42483	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42484	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42485	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42486	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42487	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42488	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42489	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42490	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42491	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42492	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42493	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42494	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42495	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42496	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42497	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42498	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42499	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42500	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42501	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42502	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42503	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				AAGCCTGAATCAGACCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42504	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42505	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42506	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42507	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42508	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42509	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42510	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42511	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42512	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42513	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42514	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42515	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42516	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42517	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42518	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42519	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42520	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42521	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42522	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42523	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42524	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GTGCGGACAAGGATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42525	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42526	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42527	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42528	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42529	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42530	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42531	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42532	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42533	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42534	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42535	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42536	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42537	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42538	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42539	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42540	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42541	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42542	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42543	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42544	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42545	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				GTATTCTTGGGTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42546	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42547	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42548	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42549	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42550	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42551	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42552	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42553	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42554	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42555	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42556	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42557	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42558	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42559	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42560	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42561	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42562	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42563	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42564	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42565	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42566	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				AAGCTGAGTCAGTTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-67948	chr17	7736660	7750138	7833342	7846820	42567	hg19	N/A	N/A	N/A	Enhatls72932	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					DNAH2	chr17	7717743	7833742	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42568	hg19	N/A	N/A	N/A	Enhatls72933	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42569	hg19	N/A	enh4233	N/A	Enhatls72933	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42570	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42571	hg19	N/A	enh4233	fant51810	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42572	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42573	hg19	N/A	enh4233	fant51811	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42574	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42575	hg19	N/A	enh4233	fant51812	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42576	hg19	N/A	enh4233	N/A	N/A	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42577	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42578	hg19	N/A	enh4233	fant51813	Enhatls72934	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42579	hg19	N/A	enh4233	N/A	Enhatls72934	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67949	chr17	7736660	7750138	7833342	7846820	42580	hg19	N/A	N/A	N/A	Enhatls72934	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1218
enhrx-67950	chr17	7736660	7750138	7833342	7846820	42581	hg19	N/A	N/A	N/A	Enhatls72935	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1219
enhrx-67951	chr17	7736660	7750138	7833342	7846820	42582	hg19	N/A	N/A	N/A	Enhatls72936	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1220
enhrx-67952	chr17	7736660	7750138	7833342	7846820	42583	hg19	N/A	N/A	N/A	Enhatls72937	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1221
enhrx-67953	chr17	7736660	7750138	7833342	7846820	42584	hg19	N/A	N/A	N/A	Enhatls72938	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1222
enhrx-67954	chr17	7736660	7750138	7833342	7846820	42585	hg19	N/A	N/A	N/A	Enhatls72939	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1223
enhrx-67955	chr17	7736660	7750138	7833342	7846820	42586	hg19	N/A	N/A	N/A	Enhatls72940	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1224
enhrx-67956	chr17	7736660	7750138	7833342	7846820	42587	hg19	N/A	N/A	N/A	Enhatls72941	enhancer	E_380				AGGAAAGGCAGCTTCCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					KDM6B	chr17	7834216	7854796	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1225
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42588	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42589	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42590	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42591	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42592	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42593	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42594	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42595	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42596	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				ATGCAAATACGTGATAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42597	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42598	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42599	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42600	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42601	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42602	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42603	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42604	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42605	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GATCGGTGTGGACTTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42606	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42607	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42608	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42609	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42610	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42611	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42612	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42613	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42614	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				ATCCCCGAGCACTCACCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42615	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42616	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42617	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42618	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42619	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42620	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42621	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42622	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42623	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GCTCCTCCAAACCCGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42624	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42625	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42626	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42627	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42628	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42629	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42630	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42631	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42632	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GCTGACCAATGAGAAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42633	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42634	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42635	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42636	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42637	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42638	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42639	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42640	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42641	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				TTCCAATCCCCGCGTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42642	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42643	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42644	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42645	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42646	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42647	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42648	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42649	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42650	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				TCACCAATCTTGGCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42651	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42652	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42653	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42654	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42655	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42656	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42657	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42658	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42659	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				CGCTCTCCAAGCTTTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42660	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42661	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42662	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42663	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42664	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42665	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42666	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42667	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42668	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				CTTGACGACACTCTTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42669	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42670	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42671	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42672	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42673	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42674	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42675	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42676	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42677	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GAGGCGCCCTAGTCACGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42678	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42679	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42680	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42681	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42682	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42683	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42684	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42685	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42686	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GTGAGAGTATTAGGGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42687	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42688	hg19	N/A	enh4236	N/A	Enhatls73033	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42689	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42690	hg19	N/A	enh4236	N/A	Enhatls73034	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42691	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42692	hg19	N/A	enh4236	N/A	Enhatls73035	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68041	chr17	8053280	8062141	8149962	8158823	42693	hg19	N/A	enh4236	N/A	N/A	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1310
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42694	hg19	N/A	enh4237	N/A	N/A	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					PER1	chr17	8140471	8156405	443				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68042	chr17	8053280	8062141	8149962	8158823	42695	hg19	N/A	enh4237	N/A	Enhatls73036	enhancer	E_381				GCTTCTCACAAACTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					VAMP2	chr17	8159148	8163546	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42696	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				AGATGAAAAAGCTGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42697	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				ACACAAAGTTTACCATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42698	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				TCACCAAACAAGCAAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42699	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				ATGTGCACTGTGACTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42700	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				AAGGGCTCTGTGTTCTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42701	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				ACATCCATGGTGCGTCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42702	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				ATTCAGTGAGGTACTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42703	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				CCAGAATCTTTATTGACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42704	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				GGTTAGGGCTTGACTTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42705	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				GATCAGCACTGGGTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42706	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				GGGTTGCTGGGAACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42707	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				CCTAGCCCTGTTTTGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8575445	8580044	8672127	8676726	42708	hg19	hs2548	enh16968	N/A	Enhatls73159	enhancer	E_382				GACGAGTCTTATGATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	40628				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42709	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTCATTTTCATTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42710	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTCATTTTCATTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42711	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTCATTTTCATTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42712	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TGTCCTCTTACTCAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42713	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				TGTCCTCTTACTCAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42714	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TGTCCTCTTACTCAGAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42715	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TTTAGCCTCCATTCACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42716	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				TTTAGCCTCCATTCACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42717	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TTTAGCCTCCATTCACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42718	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				AGTGTGACCCCTTGTGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42719	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				AGTGTGACCCCTTGTGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42720	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				AGTGTGACCCCTTGTGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42721	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTGTTGGCTGACTTAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42722	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTGTTGGCTGACTTAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42723	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				TCTGTTGGCTGACTTAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42724	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTTCACTTAAATATATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42725	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTTCACTTAAATATATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42726	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTTCACTTAAATATATTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42727	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CGACTATGAGAAAATATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42728	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				CGACTATGAGAAAATATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42729	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CGACTATGAGAAAATATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42730	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CAGAATATGTCTGTCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42731	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				CAGAATATGTCTGTCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42732	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CAGAATATGTCTGTCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42733	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTATCGTTCCTGCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42734	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTATCGTTCCTGCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42735	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				CTTATCGTTCCTGCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42736	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				GAGTGGCATTAAGCATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					MYH10	chr17	8474206	8631376	45586				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42737	hg19	hs1451	enh16968	N/A	Enhatls73159	enhancer	E_383				GAGTGGCATTAAGCATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	47935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68159	chr17	8583028	8585421	8679710	8682103	42738	hg19	N/A	enh16968	N/A	Enhatls73159	enhancer	E_383				GAGTGGCATTAAGCATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TP53	direct	Highly Significant	NA					CCDC42	chr17	8729934	8745219	45840				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1428
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42739	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42740	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42741	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42742	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42743	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42744	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42745	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42746	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42747	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42748	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42749	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42750	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42751	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42752	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42753	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42754	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCCTTTCTCTGTTATGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42755	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42756	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42757	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42758	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42759	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42760	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42761	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42762	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42763	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42764	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42765	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42766	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42767	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42768	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42769	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42770	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGTGACTGGACAACACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42771	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42772	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42773	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42774	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42775	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42776	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42777	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42778	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42779	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42780	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42781	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42782	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42783	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42784	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42785	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42786	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GCTTGTGACATATTAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42787	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42788	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42789	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42790	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42791	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42792	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42793	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42794	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42795	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42796	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42797	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42798	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42799	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42800	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42801	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42802	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTGTGTGTATAATCGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42803	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42804	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42805	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42806	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42807	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42808	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42809	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42810	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42811	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42812	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42813	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42814	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42815	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42816	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42817	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42818	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCCACATCGTGTGTCCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42819	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42820	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42821	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42822	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42823	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42824	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42825	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42826	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42827	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42828	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42829	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42830	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42831	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42832	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42833	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42834	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TGGCTTCACTAAAACCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42835	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42836	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42837	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42838	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42839	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42840	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42841	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42842	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42843	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42844	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42845	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42846	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42847	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42848	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42849	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42850	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATGGTTAGCAGTGTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42851	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42852	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42853	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42854	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42855	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42856	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42857	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42858	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42859	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42860	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42861	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42862	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42863	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42864	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42865	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42866	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				ATCCCTGCAATTAAAAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42867	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42868	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42869	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42870	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42871	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42872	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42873	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42874	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42875	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42876	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42877	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42878	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42879	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42880	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42881	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42882	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GACTCATCTAACGAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42883	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42884	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42885	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42886	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42887	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42888	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42889	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42890	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42891	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42892	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42893	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42894	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42895	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42896	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42897	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42898	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TATGAATAGTTTGCTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42899	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42900	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42901	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42902	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42903	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42904	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42905	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42906	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42907	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42908	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42909	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42910	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42911	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42912	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42913	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42914	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AATGGCGCGATCTGAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42915	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42916	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42917	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42918	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42919	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42920	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42921	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42922	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42923	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42924	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42925	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42926	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42927	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42928	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42929	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42930	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CTTTTGGTCTGGTTCCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42931	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42932	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42933	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42934	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42935	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42936	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42937	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42938	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42939	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42940	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42941	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42942	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42943	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42944	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42945	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42946	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AGAGACAGCCCAAAGCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42947	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42948	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42949	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42950	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42951	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42952	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42953	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42954	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42955	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42956	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42957	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42958	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42959	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42960	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42961	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42962	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				AACTCTGGGAGACCTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42963	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42964	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42965	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42966	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42967	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42968	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42969	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42970	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42971	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42972	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42973	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42974	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42975	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42976	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42977	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42978	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCTTGCCATAGGAAGCTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42979	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42980	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42981	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42982	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42983	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42984	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42985	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42986	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42987	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42988	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42989	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42990	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42991	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42992	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42993	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42994	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CCACCTTCACATAAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42995	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42996	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42997	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42998	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	42999	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43000	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43001	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43002	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43003	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43004	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43005	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43006	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43007	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43008	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43009	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43010	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TCAGGCCGAGTCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43011	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43012	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43013	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43014	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43015	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43016	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43017	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43018	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43019	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43020	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43021	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43022	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43023	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43024	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43025	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43026	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				GTAGCCTGCAGGCCAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43027	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43028	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43029	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43030	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43031	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43032	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43033	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43034	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43035	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43036	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43037	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43038	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43039	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43040	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43041	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43042	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TACTTATATGAACGGGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43043	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43044	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43045	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43046	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43047	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43048	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43049	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43050	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43051	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43052	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43053	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43054	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43055	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43056	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43057	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43058	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				TTGTTGTTTTTGTGTAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43059	hg19	N/A	enh17034	N/A	N/A	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43060	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43061	hg19	N/A	enh17034	fant52014	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43062	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43063	hg19	N/A	enh17034	fant52015	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43064	hg19	N/A	enh17034	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43065	hg19	N/A	N/A	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43066	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43067	hg19	N/A	enh4267	fant52016	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43068	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43069	hg19	N/A	enh4267	fant52017	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43070	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43071	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43072	hg19	hs3002	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43073	hg19	N/A	enh4267	fant52018	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68652	chr17	15843312	15871115	15939998	15967801	43074	hg19	N/A	enh4267	N/A	Enhatls73671	enhancer	E_384				CAGAATTAGTGAAATCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ADORA2B	chr17	15945129	15975746	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1921
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43075	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				TCACTTGACGACATCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43076	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				TCACTTGACGACATCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43077	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				TCACTTGACGACATCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43078	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				TCACTTGACGACATCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43079	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				TCACTTGACGACATCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43080	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				ACAGTTCTACTTAGACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43081	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				ACAGTTCTACTTAGACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43082	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				ACAGTTCTACTTAGACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43083	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				ACAGTTCTACTTAGACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43084	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				ACAGTTCTACTTAGACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43085	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				GTGGGTGTGGTGATTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43086	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				GTGGGTGTGGTGATTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43087	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				GTGGGTGTGGTGATTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43088	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTGGGTGTGGTGATTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43089	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTGGGTGTGGTGATTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43090	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				AAGTAAAGTAAGAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43091	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				AAGTAAAGTAAGAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43092	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				AAGTAAAGTAAGAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43093	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				AAGTAAAGTAAGAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43094	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				AAGTAAAGTAAGAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43095	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				CATAATCCCCCTTTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43096	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				CATAATCCCCCTTTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43097	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				CATAATCCCCCTTTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43098	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				CATAATCCCCCTTTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43099	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				CATAATCCCCCTTTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43100	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				TCCAGCATGAAGTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43101	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				TCCAGCATGAAGTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43102	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				TCCAGCATGAAGTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43103	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				TCCAGCATGAAGTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43104	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				TCCAGCATGAAGTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43105	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				GTTCAGATAACACAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43106	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				GTTCAGATAACACAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43107	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				GTTCAGATAACACAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43108	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTTCAGATAACACAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43109	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTTCAGATAACACAGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43110	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				GAGTCAGAATAGGCCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43111	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				GAGTCAGAATAGGCCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43112	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				GAGTCAGAATAGGCCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43113	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GAGTCAGAATAGGCCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43114	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GAGTCAGAATAGGCCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43115	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				GTATAGCTGAACTACTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43116	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				GTATAGCTGAACTACTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43117	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				GTATAGCTGAACTACTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43118	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTATAGCTGAACTACTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43119	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GTATAGCTGAACTACTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43120	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				GGGATTCTTTCTTAGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43121	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				GGGATTCTTTCTTAGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43122	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				GGGATTCTTTCTTAGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43123	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GGGATTCTTTCTTAGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43124	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				GGGATTCTTTCTTAGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68658	chr17	15927227	15933695	16023913	16030381	43125	hg19	N/A	N/A	N/A	Enhatls73677	enhancer	E_385				CATTTTTAGCCATTTACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1927
enhrx-68659	chr17	15927227	15933695	16023913	16030381	43126	hg19	N/A	N/A	N/A	Enhatls73678	enhancer	E_385				CATTTTTAGCCATTTACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1928
enhrx-68660	chr17	15927227	15933695	16023913	16030381	43127	hg19	N/A	N/A	N/A	Enhatls73679	enhancer	E_385				CATTTTTAGCCATTTACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1929
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43128	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				CATTTTTAGCCATTTACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TTC19	chr17	15999823	16045015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-68661	chr17	15927227	15933695	16023913	16030381	43129	hg19	N/A	N/A	N/A	Enhatls73680	enhancer	E_385				CATTTTTAGCCATTTACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					NCOR1	chr17	16029064	16218185	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1930
enhrx-lit727	chr17	16116924	16121560	16213610	16218246	43130	hg19					enhancer	E_386				TAATGGCGAAGGCTGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit728	chr17	16116924	16121560	16213610	16218246	43131	hg19					enhancer	E_386				AAGTGTAGAAGGGGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit729	chr17	16116924	16121560	16213610	16218246	43132	hg19					enhancer	E_386				GGAGCCTACAGGGCCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit730	chr17	16116924	16121560	16213610	16218246	43133	hg19					enhancer	E_386				AATGGGCTGTGGCCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit731	chr17	16116924	16121560	16213610	16218246	43134	hg19					enhancer	E_386				CCTGGGCTGCCGAGTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit732	chr17	16116924	16121560	16213610	16218246	43135	hg19					enhancer	E_386				CCGGACTAGCAGGAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit733	chr17	16116924	16121560	16213610	16218246	43136	hg19					enhancer	E_386				GTGGGAGCCGACGTGCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit734	chr17	16116924	16121560	16213610	16218246	43137	hg19					enhancer	E_386				CACCGGGACCTCGTTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit735	chr17	16116924	16121560	16213610	16218246	43138	hg19					enhancer	E_386				CGGCTGCTGCTTCGCCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit736	chr17	16116924	16121560	16213610	16218246	43139	hg19					enhancer	E_386				AGAGGCGCCCGGCCAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit737	chr17	16116924	16121560	16213610	16218246	43140	hg19					enhancer	E_386				GCAGCGGCGGTCCTCTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit738	chr17	16116924	16121560	16213610	16218246	43141	hg19					enhancer	E_386				GCGGGGGGCGCACAAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit739	chr17	16116924	16121560	16213610	16218246	43142	hg19					enhancer	E_386				GCCGCCGCCCCACCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit740	chr17	16116924	16121560	16213610	16218246	43143	hg19					enhancer	E_386				GTCCCCTCGTGGCTGGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43144	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				TATGACAGAAGATCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	indirect	Non Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43145	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				GATCACAAAGACCATGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43146	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				GCTTTGAAGTACGTCAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43147	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				CTTGGTGCAGTGGAACCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43148	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				TCTAAGGCTTGATGACCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43149	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				ACAGATGAATCATTTAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43150	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				ATATCACTCTGCCTAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43151	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				TTTTAGGGCAGAAATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43152	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				GGTTCTCCTGGCTAGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43153	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				CGATGGCCGTGATACTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43154	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				TTCCCAACTGACCAGTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43155	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				ATAGTGTCAGGTGTCAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43156	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				TCAGACCTGAGGCCAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68701	chr17	16176812	16179035	16273498	16275721	43157	hg19	N/A	enh32123	N/A	Enhatls73721	enhancer	E_387				GAAGTAAAGGAGGCCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1970
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43158	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43159	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43160	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43161	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43162	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43163	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				ATGAAGTCTAAGCTGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43164	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43165	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43166	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43167	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43168	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43169	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGAGCAGCGACGCTAGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43170	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43171	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43172	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43173	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43174	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43175	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTTAAGGCTAGCCAAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43176	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43177	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43178	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43179	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43180	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43181	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GTGGCTTGTACAGCGCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43182	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43183	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43184	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43185	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43186	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43187	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGTCTGGGGGAGAAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43188	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43189	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43190	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43191	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43192	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43193	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TCCGTTCAGTCACCAGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43194	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43195	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43196	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43197	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43198	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43199	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CTCTCCCGACTAAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43200	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43201	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43202	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43203	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43204	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43205	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGTTCATTAAAATAACGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43206	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43207	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43208	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43209	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43210	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43211	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGAACATTAAGGTCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43212	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43213	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43214	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43215	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43216	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43217	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TGTTTGCTAAATACACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43218	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43219	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43220	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43221	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43222	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43223	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTCGGGGTACCATCAGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43224	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43225	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43226	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43227	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43228	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43229	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				TTGCTGCGGGAAGGAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43230	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43231	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43232	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43233	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43234	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43235	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCCTAAGCTTCCTAAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43236	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43237	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43238	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43239	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43240	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43241	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CACACTATGTGCCAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43242	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43243	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43244	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43245	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43246	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43247	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				GGACCCACACCACCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43248	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43249	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43250	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43251	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43252	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43253	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CGCAGGCACCGAGAAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43254	hg19	N/A	enh4271	N/A	N/A	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43255	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43256	hg19	N/A	enh4271	fant52028	Enhatls73722	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43257	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43258	hg19	N/A	enh4271	fant52029	Enhatls73722	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68702	chr17	16185079	16192890	16281765	16289576	43259	hg19	N/A	enh4271	N/A	Enhatls73722	enhancer	E_388				CCGGGCAATCGCAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					PIGL	chr17	16217208	16348801	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1971
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43260	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				CCCTCATGGGCCCAGTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43261	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				CCCTCATGGGCCCAGTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43262	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				CCCTCATGGGCCCAGTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43263	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				CCCTCATGGGCCCAGTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43264	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				CCCTCATGGGCCCAGTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43265	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GCCCCACCCTTGCCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43266	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GCCCCACCCTTGCCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43267	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GCCCCACCCTTGCCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43268	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GCCCCACCCTTGCCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43269	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GCCCCACCCTTGCCAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43270	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAGCTTCCTAGGCCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43271	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GAGCTTCCTAGGCCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43272	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAGCTTCCTAGGCCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43273	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GAGCTTCCTAGGCCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43274	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GAGCTTCCTAGGCCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43275	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCCCTTCGTGAAGCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43276	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TCCCTTCGTGAAGCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43277	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCCCTTCGTGAAGCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43278	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TCCCTTCGTGAAGCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43279	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TCCCTTCGTGAAGCCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43280	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GATCCGGCTCTGCCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43281	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GATCCGGCTCTGCCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43282	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GATCCGGCTCTGCCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43283	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GATCCGGCTCTGCCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43284	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GATCCGGCTCTGCCAACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43285	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AGTCTTGGCAGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43286	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				AGTCTTGGCAGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43287	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AGTCTTGGCAGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43288	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				AGTCTTGGCAGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43289	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				AGTCTTGGCAGCAAAATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43290	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGCCAGCCAGACTGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43291	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TGCCAGCCAGACTGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43292	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGCCAGCCAGACTGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43293	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TGCCAGCCAGACTGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43294	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TGCCAGCCAGACTGTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43295	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTAATTACAGTCATAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43296	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GTAATTACAGTCATAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43297	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTAATTACAGTCATAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43298	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GTAATTACAGTCATAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43299	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GTAATTACAGTCATAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43300	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AATCCCCACCTGATTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43301	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				AATCCCCACCTGATTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43302	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AATCCCCACCTGATTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43303	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				AATCCCCACCTGATTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43304	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				AATCCCCACCTGATTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43305	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGAATGGGTCAACCAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43306	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GGAATGGGTCAACCAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43307	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGAATGGGTCAACCAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43308	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GGAATGGGTCAACCAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43309	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GGAATGGGTCAACCAAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43310	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				ATGCGAAGACAAAGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43311	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				ATGCGAAGACAAAGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43312	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				ATGCGAAGACAAAGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43313	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				ATGCGAAGACAAAGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43314	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				ATGCGAAGACAAAGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43315	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGCTGTGTTACTAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43316	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GGCTGTGTTACTAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43317	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGCTGTGTTACTAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43318	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GGCTGTGTTACTAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43319	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GGCTGTGTTACTAATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43320	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAAATCTCTCCCACAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43321	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GAAATCTCTCCCACAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43322	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAAATCTCTCCCACAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43323	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GAAATCTCTCCCACAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43324	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GAAATCTCTCCCACAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43325	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				CTCTCTGGGGATTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43326	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				CTCTCTGGGGATTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43327	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				CTCTCTGGGGATTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43328	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				CTCTCTGGGGATTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43329	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				CTCTCTGGGGATTCAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43330	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCTCCATTAGATAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43331	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TCTCCATTAGATAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43332	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCTCCATTAGATAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43333	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TCTCCATTAGATAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43334	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TCTCCATTAGATAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43335	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTTAATAGATGGTTTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43336	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GTTAATAGATGGTTTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43337	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTTAATAGATGGTTTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43338	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GTTAATAGATGGTTTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43339	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GTTAATAGATGGTTTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43340	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AGGTCCCCGCAGACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43341	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				AGGTCCCCGCAGACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43342	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AGGTCCCCGCAGACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43343	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				AGGTCCCCGCAGACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43344	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				AGGTCCCCGCAGACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43345	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AACAGCCTCGATATCCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43346	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				AACAGCCTCGATATCCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43347	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				AACAGCCTCGATATCCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43348	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				AACAGCCTCGATATCCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43349	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				AACAGCCTCGATATCCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43350	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGAAAAGTGTCTGTGATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43351	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TGAAAAGTGTCTGTGATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43352	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGAAAAGTGTCTGTGATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43353	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TGAAAAGTGTCTGTGATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43354	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TGAAAAGTGTCTGTGATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43355	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAGGATAGAGGCCCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43356	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GAGGATAGAGGCCCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43357	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GAGGATAGAGGCCCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43358	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GAGGATAGAGGCCCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43359	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GAGGATAGAGGCCCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43360	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCATGCTGGAGAAGAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43361	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TCATGCTGGAGAAGAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43362	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TCATGCTGGAGAAGAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43363	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TCATGCTGGAGAAGAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43364	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TCATGCTGGAGAAGAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43365	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGTCTCCCGGGGTGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43366	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GGTCTCCCGGGGTGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43367	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GGTCTCCCGGGGTGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43368	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GGTCTCCCGGGGTGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43369	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GGTCTCCCGGGGTGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43370	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGCCCTGTGGATCCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43371	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TGCCCTGTGGATCCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43372	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGCCCTGTGGATCCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43373	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TGCCCTGTGGATCCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43374	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TGCCCTGTGGATCCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43375	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTTCTCAGCAGCCCTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43376	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				GTTCTCAGCAGCCCTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43377	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				GTTCTCAGCAGCCCTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43378	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				GTTCTCAGCAGCCCTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43379	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				GTTCTCAGCAGCCCTCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43380	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGGACAGAGTTAATCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43381	hg19	N/A	N/A	fant52035	Enhatls73735	enhancer	E_389				TGGACAGAGTTAATCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68716	chr17	16317577	16324678	16414263	16421364	43382	hg19	N/A	N/A	N/A	Enhatls73735	enhancer	E_389				TGGACAGAGTTAATCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1985
enhrx-68717	chr17	16317577	16324678	16414263	16421364	43383	hg19	N/A	N/A	N/A	Enhatls73736	enhancer	E_389				TGGACAGAGTTAATCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1986
enhrx-68718	chr17	16317577	16324678	16414263	16421364	43384	hg19	N/A	N/A	N/A	Enhatls73737	enhancer	E_389				TGGACAGAGTTAATCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					TRPV2	chr17	16415570	16437003	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1987
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43385	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				CCCAGAACTTCGGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43386	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				CCCAGAACTTCGGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43387	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				CCCAGAACTTCGGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43388	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				CCCAGAACTTCGGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43389	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				CCCAGAACTTCGGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43390	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				TCAGATGTGATTAACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43391	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				TCAGATGTGATTAACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43392	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				TCAGATGTGATTAACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43393	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				TCAGATGTGATTAACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43394	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				TCAGATGTGATTAACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43395	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				AGGTTGTGGTGCCCAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43396	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				AGGTTGTGGTGCCCAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43397	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				AGGTTGTGGTGCCCAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43398	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				AGGTTGTGGTGCCCAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43399	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				AGGTTGTGGTGCCCAATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43400	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				TGAAGACGCTTAGCTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43401	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				TGAAGACGCTTAGCTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43402	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				TGAAGACGCTTAGCTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43403	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				TGAAGACGCTTAGCTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43404	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				TGAAGACGCTTAGCTTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43405	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GTCTGAATCCAGATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43406	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				GTCTGAATCCAGATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43407	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GTCTGAATCCAGATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43408	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				GTCTGAATCCAGATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43409	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				GTCTGAATCCAGATTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43410	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GGGGAGACCAGGCGGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43411	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				GGGGAGACCAGGCGGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43412	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GGGGAGACCAGGCGGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43413	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				GGGGAGACCAGGCGGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43414	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				GGGGAGACCAGGCGGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43415	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GAAAGTGGCCAAGCGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43416	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				GAAAGTGGCCAAGCGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43417	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GAAAGTGGCCAAGCGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43418	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				GAAAGTGGCCAAGCGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43419	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				GAAAGTGGCCAAGCGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43420	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GAGCCAGGAGGAACACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43421	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				GAGCCAGGAGGAACACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43422	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GAGCCAGGAGGAACACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43423	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				GAGCCAGGAGGAACACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43424	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				GAGCCAGGAGGAACACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43425	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				CTGCAGAAGAGGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43426	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				CTGCAGAAGAGGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43427	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				CTGCAGAAGAGGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43428	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				CTGCAGAAGAGGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43429	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				CTGCAGAAGAGGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43430	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GCCTATACCTGGTTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43431	hg19	N/A	enh17038	fant52039	Enhatls73753	enhancer	E_390				GCCTATACCTGGTTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43432	hg19	N/A	enh17038	N/A	Enhatls73753	enhancer	E_390				GCCTATACCTGGTTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43433	hg19	N/A	N/A	N/A	Enhatls73753	enhancer	E_390				GCCTATACCTGGTTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68730	chr17	16380347	16384493	16477033	16481179	43434	hg19	N/A	enh32124	N/A	Enhatls73753	enhancer	E_390				GCCTATACCTGGTTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					LRRC75A	chr17	16441576	16492193	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1999
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43435	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				GCTGTCGCATCACCTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43436	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				AGGGTCGAGGTCGAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43437	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				CTTGCGGGAGGGCAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43438	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				TCGGGCTGTCACTGATCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43439	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				TGTCGCTGGGACCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43440	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				AAGGGAAGTGGCGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43441	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				GCGAGGTCGCGGCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43442	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				GCGGCAGCTTGGGCTCCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43443	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				GGGAACTTCAAAGTTTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43444	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				TGGCGCGGGGCTTCAACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43445	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				CTGGGCGCCAGATTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68736	chr17	16471621	16472704	16568307	16569390	43446	hg19	N/A	N/A	N/A	Enhatls73759	enhancer	E_391				AAAGACTTAATGTGCGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF287	chr17	16546953	16569204	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2005
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43447	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				TGAGATTCTCAGCAAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43448	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				GTCACTCCCTGACATGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43449	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				CCTGCGCTACTCAGTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43450	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				GCAGTTAGGGAAAGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43451	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				CTTCGGGTATGCCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43452	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				CGCAGGGAGTCGAGTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43453	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				GCCGCCAGGCCCGCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43454	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				GTGTGGGTTCAGTCTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43455	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				CCTTGGCGCTTGGCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43456	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				GCCGAACTGAGGACAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43457	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				ACTAACGCAGACAAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68742	chr17	16555917	16557259	16652603	16653945	43458	hg19	N/A	N/A	N/A	Enhatls73765	enhancer	E_392				ACCTAAATGTTCCAAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					ZNF624	chr17	16620733	16653856	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2011
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43459	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				GATGCAGATTGAGAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43460	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				TCGTCCAGCACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43461	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				CACCCATCCTGACCACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43462	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				GGCTCCTTAAACCACCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43463	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				AGATGAACTGCCTCATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43464	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				AGGACTTATGCATTATTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43465	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				CTATACTTCAAGGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43466	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				TAGCTGAATCAAAACTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43467	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				CGCACCAAGCGAGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68768	chr17	16722778	16724814	16819464	16821500	43468	hg19	N/A	N/A	N/A	Enhatls73791	enhancer	E_393				GTCAATCTGCAGAAGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					CCDC144A	chr17	16690231	16777881	26631				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2037
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43469	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGGCTCCAGCTTGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43470	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GGGGCTCCAGCTTGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43471	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGGCTCCAGCTTGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43472	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GGGGCTCCAGCTTGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43473	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGGCTCCAGCTTGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43474	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCGGAAGCCAAGCCCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43475	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CCGGAAGCCAAGCCCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43476	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCGGAAGCCAAGCCCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43477	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CCGGAAGCCAAGCCCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43478	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCGGAAGCCAAGCCCATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43479	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCATGTCCTGGCGCCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43480	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CCCATGTCCTGGCGCCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43481	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCATGTCCTGGCGCCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43482	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CCCATGTCCTGGCGCCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43483	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCATGTCCTGGCGCCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43484	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATAGAGGCTCTCTAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43485	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CATAGAGGCTCTCTAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43486	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATAGAGGCTCTCTAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43487	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CATAGAGGCTCTCTAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43488	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATAGAGGCTCTCTAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43489	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCACGTTTGCAGAGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43490	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GCACGTTTGCAGAGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43491	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCACGTTTGCAGAGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43492	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GCACGTTTGCAGAGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43493	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCACGTTTGCAGAGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43494	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAAATCCTAGAGCTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43495	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CAAATCCTAGAGCTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43496	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAAATCCTAGAGCTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43497	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CAAATCCTAGAGCTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43498	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAAATCCTAGAGCTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43499	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AGGCTCCTTTGACAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43500	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				AGGCTCCTTTGACAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43501	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AGGCTCCTTTGACAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43502	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				AGGCTCCTTTGACAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43503	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AGGCTCCTTTGACAATGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43504	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCAGGGTAGGGACTTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43505	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GCAGGGTAGGGACTTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43506	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCAGGGTAGGGACTTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43507	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GCAGGGTAGGGACTTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43508	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCAGGGTAGGGACTTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43509	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCAAATCGCCAGTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43510	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CCCAAATCGCCAGTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43511	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCAAATCGCCAGTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43512	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CCCAAATCGCCAGTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43513	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCCAAATCGCCAGTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43514	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGTGTTTTCAGGACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43515	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GGGTGTTTTCAGGACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43516	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGTGTTTTCAGGACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43517	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GGGTGTTTTCAGGACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43518	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGGTGTTTTCAGGACTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43519	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGCCACACTGATAAAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43520	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GGCCACACTGATAAAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43521	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGCCACACTGATAAAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43522	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GGCCACACTGATAAAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43523	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGCCACACTGATAAAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43524	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCTATGAGGAGCTAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43525	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GCTATGAGGAGCTAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43526	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCTATGAGGAGCTAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43527	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GCTATGAGGAGCTAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43528	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GCTATGAGGAGCTAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43529	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATCATCGAAATGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43530	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CATCATCGAAATGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43531	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATCATCGAAATGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43532	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CATCATCGAAATGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43533	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CATCATCGAAATGCCAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43534	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGTCTCCCCTCCTACCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43535	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GGTCTCCCCTCCTACCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43536	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGTCTCCCCTCCTACCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43537	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GGTCTCCCCTCCTACCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43538	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GGTCTCCCCTCCTACCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43539	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTAAGTCCATAGTACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43540	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GTAAGTCCATAGTACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43541	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTAAGTCCATAGTACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43542	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GTAAGTCCATAGTACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43543	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTAAGTCCATAGTACAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43544	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ATTCCCCTGTGAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43545	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				ATTCCCCTGTGAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43546	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ATTCCCCTGTGAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43547	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				ATTCCCCTGTGAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43548	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ATTCCCCTGTGAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43549	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAGCGCCTATAAACCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43550	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CAGCGCCTATAAACCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43551	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAGCGCCTATAAACCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43552	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CAGCGCCTATAAACCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43553	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CAGCGCCTATAAACCCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43554	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTTGGAACGTCCAGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43555	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CTTGGAACGTCCAGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43556	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTTGGAACGTCCAGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43557	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CTTGGAACGTCCAGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43558	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTTGGAACGTCCAGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43559	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTTCTGTCACCCAAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43560	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				GTTCTGTCACCCAAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43561	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTTCTGTCACCCAAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43562	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				GTTCTGTCACCCAAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43563	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				GTTCTGTCACCCAAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43564	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGTATGACTTGCCCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43565	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				TGTATGACTTGCCCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43566	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGTATGACTTGCCCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43567	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				TGTATGACTTGCCCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43568	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGTATGACTTGCCCAATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43569	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCAAGGTCAGGTGGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43570	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				TTGCAAGGTCAGGTGGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43571	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCAAGGTCAGGTGGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43572	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				TTGCAAGGTCAGGTGGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43573	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCAAGGTCAGGTGGCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43574	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AAGTCTGTCCAGGCGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43575	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				AAGTCTGTCCAGGCGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43576	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AAGTCTGTCCAGGCGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43577	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				AAGTCTGTCCAGGCGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43578	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				AAGTCTGTCCAGGCGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43579	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCAGGGCTTACGTCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43580	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CCAGGGCTTACGTCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43581	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCAGGGCTTACGTCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43582	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CCAGGGCTTACGTCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43583	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCAGGGCTTACGTCAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43584	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGGCCTCAGTCCACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43585	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				TGGCCTCAGTCCACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43586	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGGCCTCAGTCCACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43587	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				TGGCCTCAGTCCACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43588	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TGGCCTCAGTCCACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43589	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TCAGGTACAATTGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43590	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				TCAGGTACAATTGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43591	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TCAGGTACAATTGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43592	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				TCAGGTACAATTGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43593	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TCAGGTACAATTGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43594	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ACGGATGGAGAGCTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43595	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				ACGGATGGAGAGCTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43596	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ACGGATGGAGAGCTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43597	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				ACGGATGGAGAGCTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43598	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				ACGGATGGAGAGCTGTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43599	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCACAGGCAGTATGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43600	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				TTGCACAGGCAGTATGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43601	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCACAGGCAGTATGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43602	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				TTGCACAGGCAGTATGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43603	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				TTGCACAGGCAGTATGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43604	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTCAAAGTCCTGATCCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43605	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CTCAAAGTCCTGATCCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43606	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTCAAAGTCCTGATCCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43607	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CTCAAAGTCCTGATCCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43608	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CTCAAAGTCCTGATCCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43609	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCTGGCAGGCTCTGTATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23697				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43610	hg19	N/A	enh4276	fant52045	Enhatls73797	enhancer	E_394				CCTGGCAGGCTCTGTATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	23531				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43611	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCTGGCAGGCTCTGTATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	21197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43612	hg19	N/A	enh4276	fant52046	Enhatls73797	enhancer	E_394				CCTGGCAGGCTCTGTATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	20801				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16915886	16936707	17012572	17033393	43613	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_394				CCTGGCAGGCTCTGTATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43614	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43615	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43616	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43617	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43618	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43619	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43620	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				CCATTAGGGGAGATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43621	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43622	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43623	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43624	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43625	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43626	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43627	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				AGGAGCAGAGAAGTAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43628	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43629	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43630	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43631	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43632	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43633	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43634	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				GCTAACTGACTCCTACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43635	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43636	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43637	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43638	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43639	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43640	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43641	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				TTGGGTGTACAGCGTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43642	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43643	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43644	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43645	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43646	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43647	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43648	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				GGGAAGGCGGAGCCGACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43649	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43650	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43651	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43652	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43653	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43654	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43655	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				GGTTTGGTGGACTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43656	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43657	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43658	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43659	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43660	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43661	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43662	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				TCTGGGCCAATGGCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43663	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43664	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43665	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43666	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43667	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43668	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43669	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				AGGTGCCGGGGCGTACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43670	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43671	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43672	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43673	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43674	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43675	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43676	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				GAGCGCCTCACGCACTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43677	hg19	N/A	enh4276	N/A	Enhatls73797	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4916				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68776	chr17	16938495	16960394	17035181	17057080	43678	hg19	N/A	N/A	N/A	Enhatls73797	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	4701				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2045
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43679	hg19	N/A	enh52436	N/A	N/A	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43680	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43681	hg19	N/A	enh52436	fant52047	Enhatls73798	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43682	hg19	N/A	enh52436	N/A	Enhatls73798	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68777	chr17	16938495	16960394	17035181	17057080	43683	hg19	N/A	N/A	N/A	Enhatls73798	enhancer	E_395				GCGCGGACGAGCCGGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2046
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43684	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43685	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43686	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43687	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43688	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43689	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43690	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43691	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43692	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43693	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43694	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43695	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43696	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43697	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AAGTGGATCGCTGGAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43698	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43699	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43700	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43701	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43702	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43703	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43704	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43705	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43706	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43707	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43708	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43709	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43710	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43711	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				GACACCAGTTGTGAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43712	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43713	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43714	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43715	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43716	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43717	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43718	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43719	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43720	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43721	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43722	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43723	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43724	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43725	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AATTCACTAGAATGACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43726	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43727	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43728	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43729	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43730	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43731	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43732	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43733	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43734	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43735	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43736	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43737	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43738	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43739	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				ATGTAAGTCAGAACCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43740	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43741	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43742	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43743	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43744	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43745	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43746	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43747	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43748	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43749	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43750	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43751	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43752	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43753	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				CCTCCTAAAACTCAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43754	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43755	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43756	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43757	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43758	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43759	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43760	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43761	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43762	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43763	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43764	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43765	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43766	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43767	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				TTAGGTGGAGTTCAACTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43768	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43769	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43770	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43771	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43772	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43773	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43774	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43775	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43776	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43777	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43778	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43779	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43780	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43781	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AGACAACTCAGGGTAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43782	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43783	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43784	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43785	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43786	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43787	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43788	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43789	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43790	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43791	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43792	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43793	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43794	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43795	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				GGGAGGTAACTTCCAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43796	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43797	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43798	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43799	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43800	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43801	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43802	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43803	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43804	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43805	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43806	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43807	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43808	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43809	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AGTTAGTTCGTCACTCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43810	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43811	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43812	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43813	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43814	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43815	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43816	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43817	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43818	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43819	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43820	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43821	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43822	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43823	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AGTAGAGAGCTGCCCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43824	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43825	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43826	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43827	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43828	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43829	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43830	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43831	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43832	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43833	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43834	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43835	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43836	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43837	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				CTGGTGGGCTCACCTGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43838	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43839	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43840	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43841	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43842	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43843	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43844	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43845	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43846	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43847	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43848	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43849	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43850	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43851	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				GAGAGTTGATCCAGTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43852	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43853	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43854	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43855	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43856	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43857	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43858	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43859	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43860	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43861	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43862	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43863	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43864	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43865	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AGACTGAAGTATAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43866	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43867	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43868	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43869	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43870	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43871	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43872	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43873	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43874	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43875	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43876	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43877	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43878	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43879	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				TCTCGCAGATGCCTGCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43880	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43881	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43882	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43883	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43884	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43885	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43886	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43887	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43888	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43889	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43890	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43891	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43892	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43893	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AGACAACTCACACCCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43894	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43895	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43896	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43897	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43898	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43899	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43900	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43901	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43902	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43903	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43904	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43905	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43906	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43907	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				AAGCTGCTCATGAAGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43908	hg19	N/A	N/A	N/A	Enhatls73806	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43909	hg19	N/A	enh81190	N/A	Enhatls73806	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43910	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43911	hg19	N/A	enh81190	N/A	Enhatls73807	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43912	hg19	N/A	enh81190	N/A	N/A	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43913	hg19	N/A	enh81190	N/A	Enhatls73808	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43914	hg19	N/A	N/A	N/A	Enhatls73808	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43915	hg19	N/A	enh65023	N/A	Enhatls73808	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43916	hg19	N/A	enh65023	N/A	N/A	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43917	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43918	hg19	N/A	enh65023	fant52049	Enhatls73809	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43919	hg19	N/A	enh65023	N/A	Enhatls73809	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68784	chr17	17047553	17060161	17144239	17156847	43920	hg19	N/A	N/A	N/A	Enhatls73809	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2053
enhrx-68785	chr17	17047553	17060161	17144239	17156847	43921	hg19	N/A	N/A	N/A	Enhatls73810	enhancer	E_396				GGTTGATCAGTGGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TNFRSF13B	direct	Highly Significant	NA					MPRIP	chr17	17042456	17217679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2054
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43922	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				CAGTAATGAGTGTGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43923	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				CAGTAATGAGTGTGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43924	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CAGTAATGAGTGTGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43925	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				CAGTAATGAGTGTGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43926	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CAGTAATGAGTGTGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43927	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GCACGCAGTGCTGTTAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43928	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GCACGCAGTGCTGTTAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43929	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCACGCAGTGCTGTTAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43930	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GCACGCAGTGCTGTTAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43931	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCACGCAGTGCTGTTAACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43932	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				CCCAAACTTGAGCCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43933	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				CCCAAACTTGAGCCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43934	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CCCAAACTTGAGCCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43935	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				CCCAAACTTGAGCCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43936	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CCCAAACTTGAGCCACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43937	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				CAGTGTTTCAGACACTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43938	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				CAGTGTTTCAGACACTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43939	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CAGTGTTTCAGACACTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43940	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				CAGTGTTTCAGACACTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43941	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CAGTGTTTCAGACACTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43942	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GGGACTATGCACACGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43943	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GGGACTATGCACACGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43944	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GGGACTATGCACACGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43945	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GGGACTATGCACACGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43946	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GGGACTATGCACACGCATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43947	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GCAGTGGGTTAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43948	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GCAGTGGGTTAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43949	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCAGTGGGTTAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43950	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GCAGTGGGTTAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43951	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCAGTGGGTTAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43952	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				AGGGGTGAGTCAAGGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43953	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				AGGGGTGAGTCAAGGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43954	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AGGGGTGAGTCAAGGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43955	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				AGGGGTGAGTCAAGGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43956	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AGGGGTGAGTCAAGGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43957	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				AAGGCAGCTCACCTTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43958	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				AAGGCAGCTCACCTTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43959	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AAGGCAGCTCACCTTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43960	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				AAGGCAGCTCACCTTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43961	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AAGGCAGCTCACCTTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43962	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				TGGGGCATGTGTGTATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43963	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				TGGGGCATGTGTGTATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43964	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGGGCATGTGTGTATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43965	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				TGGGGCATGTGTGTATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43966	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGGGCATGTGTGTATAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43967	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				TGGAAGAAAACAGTGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43968	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				TGGAAGAAAACAGTGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43969	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGAAGAAAACAGTGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43970	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				TGGAAGAAAACAGTGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43971	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGAAGAAAACAGTGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43972	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				TGGGGTTGCATCCACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43973	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				TGGGGTTGCATCCACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43974	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGGGTTGCATCCACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43975	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				TGGGGTTGCATCCACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43976	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TGGGGTTGCATCCACCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43977	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GAAGCCTCAAAACCCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43978	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GAAGCCTCAAAACCCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43979	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GAAGCCTCAAAACCCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43980	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GAAGCCTCAAAACCCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43981	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GAAGCCTCAAAACCCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43982	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				TCTTACCAAGAAGCTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43983	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				TCTTACCAAGAAGCTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43984	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TCTTACCAAGAAGCTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43985	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				TCTTACCAAGAAGCTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43986	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TCTTACCAAGAAGCTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43987	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				ACCTACTTCAGCCACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43988	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				ACCTACTTCAGCCACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43989	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				ACCTACTTCAGCCACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43990	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				ACCTACTTCAGCCACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43991	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				ACCTACTTCAGCCACATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43992	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GGAAATAGCATGAGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43993	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GGAAATAGCATGAGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43994	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GGAAATAGCATGAGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43995	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GGAAATAGCATGAGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43996	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GGAAATAGCATGAGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43997	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GCTCGGGACGGGAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43998	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GCTCGGGACGGGAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	43999	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCTCGGGACGGGAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44000	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GCTCGGGACGGGAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44001	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GCTCGGGACGGGAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44002	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				ATACAGCAGTGTGTGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44003	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				ATACAGCAGTGTGTGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44004	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				ATACAGCAGTGTGTGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44005	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				ATACAGCAGTGTGTGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44006	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				ATACAGCAGTGTGTGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44007	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				AGGGGGTTAGGGCAAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44008	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				AGGGGGTTAGGGCAAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44009	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AGGGGGTTAGGGCAAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44010	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				AGGGGGTTAGGGCAAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44011	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				AGGGGGTTAGGGCAAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44012	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				TCAAGCTTGGCCTGTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44013	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				TCAAGCTTGGCCTGTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44014	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TCAAGCTTGGCCTGTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44015	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				TCAAGCTTGGCCTGTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44016	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				TCAAGCTTGGCCTGTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44017	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				GATTGAATGTTCGTGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44018	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				GATTGAATGTTCGTGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44019	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GATTGAATGTTCGTGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44020	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				GATTGAATGTTCGTGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44021	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				GATTGAATGTTCGTGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44022	hg19	N/A	enh81196	N/A	Enhatls74791	enhancer	E_397				CCTCTGCCGCAGTAATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44023	hg19	N/A	N/A	N/A	Enhatls74791	enhancer	E_397				CCTCTGCCGCAGTAATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44024	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CCTCTGCCGCAGTAATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44025	hg19	N/A	enh4319	fant52246	Enhatls74791	enhancer	E_397				CCTCTGCCGCAGTAATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-69677	chr17	27458456	27470203	29131438	29143185	44026	hg19	N/A	enh4319	N/A	Enhatls74791	enhancer	E_397				CCTCTGCCGCAGTAATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TAOK1	direct	Highly Significant	NA					MYO18A	chr17	29071121	29180398	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2946
enhrx-lit741	chr17	28703271	28707491	30376253	30380473	44027	hg19					enhancer	E_401				TTAATGCTTAGAACCGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit742	chr17	28703271	28707491	30376253	30380473	44028	hg19					enhancer	E_401				AGGAGTTCTCAGAGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit743	chr17	28703271	28707491	30376253	30380473	44029	hg19					enhancer	E_401				ACGCAGAAGACGAAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit744	chr17	28703271	28707491	30376253	30380473	44030	hg19					enhancer	E_401				ACTCGTCCCGGACGGGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit745	chr17	28703271	28707491	30376253	30380473	44031	hg19					enhancer	E_401				GGAGCGTCACCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit746	chr17	28703271	28707491	30376253	30380473	44032	hg19					enhancer	E_401				GATTGGCTGCGGCCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit747	chr17	28703271	28707491	30376253	30380473	44033	hg19					enhancer	E_401				TTAGCGGCGCTGCTGGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit748	chr17	28703271	28707491	30376253	30380473	44034	hg19					enhancer	E_401				GTAGCGGTCGAACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit749	chr17	28703271	28707491	30376253	30380473	44035	hg19					enhancer	E_401				TAAAGAGGCGGGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit750	chr17	28703271	28707491	30376253	30380473	44036	hg19					enhancer	E_401				GTGAGGCGAAGCACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit751	chr17	28703271	28707491	30376253	30380473	44037	hg19					enhancer	E_401				TAATCCCTGAGGGCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit752	chr17	28703271	28707491	30376253	30380473	44038	hg19					enhancer	E_401				CTACTTGGCCCGCGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit753	chr17	28703271	28707491	30376253	30380473	44039	hg19					enhancer	E_401				GGGCACGCTCGAAGCCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"NF1,TAOK1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44040	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				AGGACTAAGGGGCGAGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44041	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				AAGAGGTGGGACAGTGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44042	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GGAGACTGGTAAAAAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44043	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GGGACCAGAGCAGAATCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44044	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GAGGAGCGTTCACTAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44045	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				AGTCTGGGAACGGGGAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44046	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GTGGGACTGTCCGAAAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44047	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				TCGGAGGGCCACACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44048	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GCCGGTGACCCAGCTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44049	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GCGGTGCTTCCGCCTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44050	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				CTTGATTGACGGGCGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44051	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				TGCGGGTTATCAACCTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44052	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				GGAAATTGAGGGATAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69855	chr17	29150753	29152702	30823735	30825684	44053	hg19	N/A	N/A	N/A	Enhatls74990	enhancer	E_404				TGGAGTTCGAGACCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					CRLF3	chr17	30772362	30824692	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3124
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44054	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GGAGAAGGAGGTCCAAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44055	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GTGGCAGGCGCTGAGGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44056	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				ACTAACCACTTTCTTCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44057	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GTGGAGTTACCAAGATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44058	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GTGGTCCGGCCAGTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44059	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				CTGACTCATGCTGGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44060	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GTACAAAGTACGAAGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44061	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				TGAATCACTCCCAACCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44062	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GGTGTCTTCAAATCCAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44063	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GGTGGGCTGTGATACTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44064	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				TTCTCCCTGACGGGGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44065	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				GTGAAACCTTGTTCTAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44066	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				ACGCAAGTCACTCTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29377884	29381436	31050866	31054418	44067	hg19	N/A	enh17093	N/A	Enhatls75030	enhancer	E_405				AAGCCGATAATGGGAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	40062				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44068	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				AGGTGAGCGAAGTGAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44069	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				AACTGGCTTCCAGGAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44070	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				ATAATCATAGATTGAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44071	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				TGATAGAGGAGATCTAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44072	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				CTGAATTCAACTCAGTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44073	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				TTCTAGGTCAAAGGTCTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44074	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				AAAGCAAAGGCTTGTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44075	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				TTTGAAACTGGGATGCTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44076	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				CTTTGTCTCTGAAAGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44077	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				TCAGCTTCAGCCAGGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44078	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				GCTGCTGTCTAACCTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69893	chr17	29393818	29399474	31066800	31072456	44079	hg19	N/A	enh17094	N/A	Enhatls75030	enhancer	E_406				GAATCATCAGTCAGACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	17408				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3162
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44080	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				ATACATCTCTTGATTTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44081	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				ATACATCTCTTGATTTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44082	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				ATACATCTCTTGATTTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44083	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TGCAGAACATCTGTCTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44084	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				TGCAGAACATCTGTCTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44085	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TGCAGAACATCTGTCTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44086	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				ACCATTACCAGCCACAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44087	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				ACCATTACCAGCCACAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44088	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				ACCATTACCAGCCACAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44089	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				GTGGTTTCAGCAAAAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44090	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				GTGGTTTCAGCAAAAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44091	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				GTGGTTTCAGCAAAAGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44092	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TAAGGCAGTCACTATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44093	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				TAAGGCAGTCACTATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44094	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TAAGGCAGTCACTATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44095	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TAGTTCATGCAATTTGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44096	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				TAGTTCATGCAATTTGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44097	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				TAGTTCATGCAATTTGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44098	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				GTTACTAGAATGAGGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44099	hg19	N/A	enh32163	fant52293	Enhatls75060	enhancer	E_407				GTTACTAGAATGAGGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69922	chr17	29595173	29597211	31268155	31270193	44100	hg19	N/A	enh32163	N/A	Enhatls75060	enhancer	E_407				GTTACTAGAATGAGGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3191
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44101	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				GAACATGTAATTTTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44102	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				GAACATGTAATTTTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44103	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				GAACATGTAATTTTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44104	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				GAACATGTAATTTTCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44105	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				ACTGTAAGTGATAACCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44106	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				ACTGTAAGTGATAACCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44107	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				ACTGTAAGTGATAACCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44108	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				ACTGTAAGTGATAACCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44109	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				CCTCTAAAGGAATATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44110	hg19	N/A	enh4359	N/A	Enhatls75063	enhancer	E_408				CCTCTAAAGGAATATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44111	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				CCTCTAAAGGAATATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2B	chr17	31303769	31314105	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69925	chr17	29638743	29641442	31311725	31314424	44112	hg19	N/A	N/A	N/A	Enhatls75063	enhancer	E_408				CCTCTAAAGGAATATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3194
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44113	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				CTGCTTGATTCTAAATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44114	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				CTGCTTGATTCTAAATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44115	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AGATAATCAGAACAACACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44116	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AGATAATCAGAACAACACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44117	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AGTAGCAATGAGAAGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44118	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AGTAGCAATGAGAAGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44119	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				TGGAGTGCTCACAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44120	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				TGGAGTGCTCACAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44121	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AAGCGTCAGCCTAGAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44122	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				AAGCGTCAGCCTAGAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44123	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				CTTTCTATTTCTATCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44124	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				CTTTCTATTTCTATCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44125	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				TTTCAAAAAGGATGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44126	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				TTTCAAAAAGGATGTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44127	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				GGACTGTTGCTGACGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69926	chr17	29643355	29646218	31316337	31319200	44128	hg19	N/A	N/A	N/A	Enhatls75064	enhancer	E_409				GGACTGTTGCTGACGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3195
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44129	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				AAAGAAGACAAGAAAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44130	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				AAAGAAGACAAGAAAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44131	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				TTTACTGCAGATTTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44132	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				TTTACTGCAGATTTACTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44133	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				GACATGTGCTTTAGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44134	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				GACATGTGCTTTAGTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44135	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				TTGGCCACTGGCATGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44136	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				TTGGCCACTGGCATGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44137	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				ATGACACTAAAGCATGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					NF1	chr17	31094926	31377687	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69927	chr17	29647562	29649267	31320544	31322249	44138	hg19	N/A	N/A	N/A	Enhatls75065	enhancer	E_410				ATGACACTAAAGCATGTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					EVI2A	chr17	31316409	31321749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3196
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44139	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GTAGAGGGGGTATGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44140	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				GTAGAGGGGGTATGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44141	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GTAGAGGGGGTATGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44142	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				GTAGAGGGGGTATGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44143	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GTAAGTCTGACTGATTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44144	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				GTAAGTCTGACTGATTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44145	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GTAAGTCTGACTGATTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44146	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				GTAAGTCTGACTGATTCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44147	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				ACAGTGGGATGTTTTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44148	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				ACAGTGGGATGTTTTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44149	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				ACAGTGGGATGTTTTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44150	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				ACAGTGGGATGTTTTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44151	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GCAACACCGGCCTGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44152	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				GCAACACCGGCCTGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44153	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GCAACACCGGCCTGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44154	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				GCAACACCGGCCTGAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44155	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				TTAATGGAGAGGGCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44156	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				TTAATGGAGAGGGCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44157	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				TTAATGGAGAGGGCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44158	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				TTAATGGAGAGGGCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44159	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GGTGGCGGCTCCAGAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44160	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				GGTGGCGGCTCCAGAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44161	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GGTGGCGGCTCCAGAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44162	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				GGTGGCGGCTCCAGAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44163	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				AGCATCTCGCCTGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44164	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				AGCATCTCGCCTGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44165	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				AGCATCTCGCCTGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44166	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				AGCATCTCGCCTGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44167	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				TGTAAGAGGGGAATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44168	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				TGTAAGAGGGGAATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44169	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				TGTAAGAGGGGAATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44170	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				TGTAAGAGGGGAATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44171	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GATGCACTTGAGTGCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44172	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				GATGCACTTGAGTGCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44173	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				GATGCACTTGAGTGCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44174	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				GATGCACTTGAGTGCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44175	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				ATATGGGCGATAGGAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44176	hg19	N/A	enh44407	fant52296	Enhatls75085	enhancer	E_411				ATATGGGCGATAGGAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44177	hg19	N/A	enh44407	N/A	Enhatls75085	enhancer	E_411				ATATGGGCGATAGGAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69948	chr17	29738824	29746267	31411806	31419249	44178	hg19	N/A	N/A	N/A	Enhatls75085	enhancer	E_411				ATATGGGCGATAGGAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3217
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44179	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				ACCTGGGCTGGTGGGGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44180	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				ATGTGGCCTTGTGATCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44181	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				TTCTGTGTTCACGTAGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44182	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				AACAGTGGCTCCGTGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44183	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				TTATCCCCTGAATAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44184	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				GCCCCACCACCTTCTCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44185	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				AATTTAGGAGACAATTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69950	chr17	29802941	29804297	31475923	31477279	44186	hg19	N/A	enh44409	N/A	Enhatls75087	enhancer	E_412				ACGACTCTGAGTCTGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					RAB11FIP4	chr17	31391674	31538211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3219
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44187	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GCTCCTGTGTACAGTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44188	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				GCTCCTGTGTACAGTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44189	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GCTCCTGTGTACAGTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44190	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TGGAGCCTACTTTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44191	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				TGGAGCCTACTTTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44192	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TGGAGCCTACTTTTAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44193	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TCACAGGGGAATGAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44194	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				TCACAGGGGAATGAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44195	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TCACAGGGGAATGAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44196	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				ACAACAACTGAGGTGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44197	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				ACAACAACTGAGGTGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44198	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				ACAACAACTGAGGTGCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44199	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TGTTTCCAACAGCAAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44200	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				TGTTTCCAACAGCAAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44201	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				TGTTTCCAACAGCAAGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44202	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				CCACTTTCTGAGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44203	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				CCACTTTCTGAGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44204	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				CCACTTTCTGAGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44205	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				CCTCGCCCTGGAATCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44206	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				CCTCGCCCTGGAATCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44207	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				CCTCGCCCTGGAATCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44208	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GAAAGCCACCTGATAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44209	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				GAAAGCCACCTGATAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44210	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GAAAGCCACCTGATAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44211	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GTATCCATCGAGATGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63661				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44212	hg19	N/A	enh32168	fant52321	Enhatls75097	enhancer	E_413				GTATCCATCGAGATGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	63283				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-69959	chr17	30114478	30115889	31787459	31788870	44213	hg19	N/A	enh32168	N/A	Enhatls75097	enhancer	E_413				GTATCCATCGAGATGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF1	direct	Highly Significant	NA					COPRS	chr17	31851870	31859244	60655				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3228
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44214	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44215	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44216	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44217	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44218	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44219	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TAAAGCGTACAGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44220	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44221	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44222	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44223	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44224	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44225	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGTTGAGGCTGGAAGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44226	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44227	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44228	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44229	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44230	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44231	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCAGTCTCCCACCGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44232	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44233	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44234	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44235	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44236	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44237	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CTCTGAACCGGAGCCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44238	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44239	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44240	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44241	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44242	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44243	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGAGGCGGCCGTTAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44244	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44245	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44246	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44247	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44248	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44249	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GGGACCGGTATAAAGTCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44250	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44251	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44252	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44253	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44254	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44255	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TCGCCGCCCGCCGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44256	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44257	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44258	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44259	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44260	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44261	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAAGTTAGCAGGCGTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44262	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44263	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44264	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44265	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44266	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44267	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GAGCGGCGGAGGGCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44268	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44269	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44270	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44271	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44272	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44273	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				AGGGCGGCCACGAGGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44274	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44275	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44276	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44277	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44278	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44279	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCTCCTCGCAGCCCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44280	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44281	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44282	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44283	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44284	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44285	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				CGGGGGGTGTACACCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44286	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44287	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44288	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44289	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44290	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44291	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCGCTGCTACCCGCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44292	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44293	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44294	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44295	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44296	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44297	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				GCCAGGGGTACCTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44298	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44299	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44300	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44301	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44302	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44303	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGAGTGCGCTCCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44304	hg19	N/A	N/A	N/A	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44305	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44306	hg19	N/A	enh52499	fant52612	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44307	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44308	hg19	N/A	enh52499	fant52613	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38598575	38606475	40442323	40450223	44309	hg19	N/A	enh52499	N/A	Enhatls76172	enhancer	E_419				TGGCAGGGCCCGACTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					IGFBP4	chr17	40443449	40457725	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44310	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44311	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44312	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44313	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44314	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44315	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44316	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44317	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44318	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44319	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44320	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44321	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44322	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44323	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44324	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44325	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44326	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44327	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44328	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44329	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44330	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44331	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44332	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				CCACTCACGAAGCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44333	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44334	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44335	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44336	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44337	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44338	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44339	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44340	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44341	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44342	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44343	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44344	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44345	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44346	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44347	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44348	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44349	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44350	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44351	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44352	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44353	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44354	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44355	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				CATCAAGGCGACTCCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44356	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44357	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44358	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44359	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44360	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44361	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44362	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44363	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44364	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44365	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44366	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44367	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44368	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44369	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44370	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44371	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44372	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44373	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44374	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44375	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44376	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44377	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44378	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				GGGGCTGAGAAGCCCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44379	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44380	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44381	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44382	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44383	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44384	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44385	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44386	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44387	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44388	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44389	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44390	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44391	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44392	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44393	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44394	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44395	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44396	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44397	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44398	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44399	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44400	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44401	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TCATGGGAGAGGCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44402	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44403	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44404	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44405	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44406	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44407	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44408	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44409	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44410	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44411	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44412	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44413	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44414	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44415	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44416	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44417	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44418	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44419	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44420	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44421	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44422	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44423	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44424	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGGTTTTCGGCTGTCTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44425	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44426	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44427	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44428	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44429	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44430	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44431	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44432	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44433	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44434	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44435	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44436	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44437	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44438	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44439	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44440	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44441	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44442	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44443	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44444	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44445	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44446	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44447	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TAGTCATCAAGCACATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44448	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44449	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44450	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44451	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44452	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44453	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44454	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44455	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44456	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44457	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44458	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44459	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44460	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44461	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44462	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44463	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44464	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44465	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44466	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44467	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44468	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44469	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44470	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGGCAGCTCAACGGATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44471	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44472	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44473	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44474	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44475	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44476	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44477	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44478	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44479	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44480	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44481	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44482	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44483	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44484	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44485	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44486	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44487	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44488	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44489	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44490	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44491	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44492	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44493	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGTGTGAGGAGGCTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44494	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44495	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44496	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44497	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44498	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44499	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44500	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44501	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44502	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44503	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44504	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44505	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44506	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44507	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44508	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44509	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44510	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44511	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44512	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44513	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44514	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44515	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44516	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				ATTTGAAACCAGATTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44517	hg19	N/A	enh17140	N/A	Enhatls76178	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44518	hg19	N/A	enh17140	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44519	hg19	N/A	enh17140	N/A	Enhatls76179	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44520	hg19	N/A	N/A	N/A	Enhatls76179	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44521	hg19	N/A	enh62615	N/A	Enhatls76179	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44522	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44523	hg19	N/A	enh62615	N/A	Enhatls76180	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44524	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44525	hg19	N/A	enh62615	N/A	Enhatls76181	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44526	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44527	hg19	N/A	enh62615	N/A	Enhatls76182	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44528	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44529	hg19	N/A	enh62615	N/A	Enhatls76183	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44530	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44531	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44532	hg19	N/A	enh62615	fant52615	Enhatls76184	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44533	hg19	N/A	enh62615	N/A	Enhatls76184	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44534	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44535	hg19	N/A	enh62615	N/A	Enhatls76185	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44536	hg19	N/A	enh62615	N/A	N/A	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44537	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44538	hg19	N/A	enh62615	fant52616	Enhatls76186	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-70993	chr17	38635167	38647921	40478915	40491669	44539	hg19	N/A	enh62615	N/A	Enhatls76186	enhancer	E_420				TGAACCTGCACCCAACATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1,MED24"	direct	Highly Significant	NA					TNS4	chr17	40475833	40501623	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4262
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44540	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				ATCCAGCTAGGATATATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44541	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				CAACGGGCAGCTACAACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44542	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				TGACCAGGTATTCCGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44543	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				TTGCACCTTCTCACATGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44544	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				TCCCATGCTTAAGTCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44545	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				TCACAGGCTGGGTTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44546	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				GCACTGTGTCATTAAACACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-71090	chr17	39214709	39218418	41058457	41062166	44547	hg19	N/A	N/A	fant52659	N/A	enhancer	E_423				GGTACTGTACTATTTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA					KRTAP2-3	chr17	41059239	41060114	1803				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4359
enhrx-lit754	chr17	39238261	39241347	41082009	41085095	44548	hg19					enhancer	E_424				GGTGACACCACCCTCATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit755	chr17	39238261	39241347	41082009	41085095	44549	hg19					enhancer	E_424				AATACCATGTTATCCCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit756	chr17	39238261	39241347	41082009	41085095	44550	hg19					enhancer	E_424				ATAGCATATGTGGAACCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit757	chr17	39238261	39241347	41082009	41085095	44551	hg19					enhancer	E_424				GAAAACTACAATTATTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit758	chr17	39238261	39241347	41082009	41085095	44552	hg19					enhancer	E_424				TTGACTTCTGGATAAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit759	chr17	39238261	39241347	41082009	41085095	44553	hg19					enhancer	E_424				GTTCTCTGTGCTGAGTATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit760	chr17	39238261	39241347	41082009	41085095	44554	hg19					enhancer	E_424				GCTATTTGCATTGCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit761	chr17	39238261	39241347	41082009	41085095	44555	hg19					enhancer	E_424				AATGAATGGGGTAGTTTATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit762	chr17	39238261	39241347	41082009	41085095	44556	hg19					enhancer	E_424				CTGAAACTGCTTCATCTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TOP2A,SMARCE1"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44557	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44558	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44559	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44560	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44561	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44562	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44563	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44564	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44565	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44566	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44567	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44568	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				AGCGGTTTGGACTGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44569	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44570	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44571	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44572	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44573	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44574	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44575	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44576	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44577	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44578	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44579	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44580	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GCCTCCTCATTAGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44581	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44582	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44583	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44584	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44585	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44586	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44587	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44588	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44589	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44590	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44591	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44592	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGCTGCACTGCCTCATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44593	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44594	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44595	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44596	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44597	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44598	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44599	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44600	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44601	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44602	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44603	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44604	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				AATGCTCACTATGGCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44605	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44606	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44607	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44608	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44609	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44610	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44611	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44612	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44613	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44614	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44615	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44616	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGGGTTTAAAGGTAAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44617	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44618	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44619	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44620	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44621	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44622	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44623	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44624	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44625	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44626	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44627	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44628	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				TAAGGCTCAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44629	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44630	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44631	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44632	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44633	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44634	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44635	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44636	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44637	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44638	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44639	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44640	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				AGCTCAGCCTGACTCTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44641	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44642	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44643	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44644	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44645	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44646	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44647	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44648	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44649	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44650	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44651	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44652	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				TTACATCCTGCTGGTCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44653	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44654	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44655	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44656	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44657	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44658	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44659	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44660	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44661	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44662	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44663	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44664	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GCCTGGAGACCTGGGATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44665	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44666	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44667	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44668	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44669	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44670	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44671	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44672	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44673	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44674	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44675	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44676	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				AGGTCTCAGGCCTGAGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44677	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44678	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44679	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44680	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44681	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44682	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44683	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44684	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44685	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44686	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44687	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44688	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				CCTGGAATGTGGCTGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44689	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44690	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44691	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44692	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44693	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44694	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44695	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44696	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44697	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44698	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44699	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44700	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				TGGGCAGGGACAAGCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44701	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44702	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44703	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44704	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44705	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44706	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44707	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44708	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44709	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44710	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44711	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44712	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGCTTCCTGAGAAGTTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44713	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44714	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44715	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44716	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44717	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44718	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44719	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44720	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44721	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44722	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44723	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44724	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGCTACAGCAGCGGGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44725	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44726	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44727	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44728	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44729	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44730	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44731	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44732	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44733	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44734	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44735	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44736	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGATTGCCATGGCCGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44737	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44738	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44739	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44740	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44741	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44742	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44743	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44744	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44745	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44746	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44747	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44748	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GAAGTCCCACTTCTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44749	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44750	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44751	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44752	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44753	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44754	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44755	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44756	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44757	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44758	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44759	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44760	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GTACAACTCTGCCCTTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44761	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44762	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44763	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44764	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44765	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44766	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44767	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44768	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44769	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44770	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44771	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44772	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				TTATGGCAAAGCATTCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44773	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44774	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44775	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44776	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44777	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44778	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44779	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44780	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44781	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44782	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44783	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44784	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GAAAACTGAGACCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44785	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44786	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44787	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44788	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44789	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44790	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44791	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44792	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44793	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44794	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44795	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44796	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GGTGATAATACACAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44797	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44798	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44799	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44800	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44801	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44802	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44803	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44804	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44805	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44806	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44807	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44808	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GCTGGGAACTTAGGTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44809	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44810	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44811	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44812	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44813	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44814	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44815	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44816	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44817	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44818	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44819	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44820	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				CCTCAGACTGGCCTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44821	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44822	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44823	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44824	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44825	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44826	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44827	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44828	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44829	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44830	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44831	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44832	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				TCCTCATCAGTGCCTGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44833	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44834	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44835	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44836	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44837	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44838	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44839	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44840	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44841	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44842	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44843	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44844	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				CATGCACACAAAGCCCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44845	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44846	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44847	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44848	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44849	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44850	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44851	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44852	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44853	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44854	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44855	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44856	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GAACACCTTAATCTTACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44857	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44858	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44859	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44860	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44861	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44862	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44863	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44864	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44865	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44866	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44867	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44868	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				GTTTATGGTCTTAGAGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44869	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44870	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44871	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44872	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44873	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44874	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44875	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44876	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44877	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44878	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44879	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44880	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				AGAGCCTTTTCAGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71169	chr17	39675373	39689360	41519121	41533108	44881	hg19	N/A	N/A	N/A	Enhatls76365	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4438
enhrx-71170	chr17	39675373	39689360	41519121	41533108	44882	hg19	N/A	N/A	N/A	Enhatls76366	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4439
enhrx-71171	chr17	39675373	39689360	41519121	41533108	44883	hg19	N/A	N/A	N/A	Enhatls76367	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4440
enhrx-71172	chr17	39675373	39689360	41519121	41533108	44884	hg19	N/A	N/A	N/A	Enhatls76368	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4441
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44885	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44886	hg19	N/A	N/A	fant52670	Enhatls76369	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44887	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44888	hg19	N/A	N/A	fant52671	Enhatls76369	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71173	chr17	39675373	39689360	41519121	41533108	44889	hg19	N/A	N/A	N/A	Enhatls76369	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4442
enhrx-71174	chr17	39675373	39689360	41519121	41533108	44890	hg19	N/A	N/A	fant52672	N/A	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	832				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4443
enhrx-71175	chr17	39675373	39689360	41519121	41533108	44891	hg19	N/A	N/A	fant52673	N/A	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	1899				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4444
enhrx-71176	chr17	39675373	39689360	41519121	41533108	44892	hg19	N/A	enh17150	N/A	N/A	enhancer	E_425				CCATCAGCCAAGAGTAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCE1	direct	Highly Significant	NA					KRT19	chr17	41523616	41528308	4346				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4445
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44893	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44894	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44895	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44896	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44897	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44898	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44899	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44900	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44901	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44902	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44903	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44904	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44905	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44906	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44907	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44908	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CGGTCACTATGGGGTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44909	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44910	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44911	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44912	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44913	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44914	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44915	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44916	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44917	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44918	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44919	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44920	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44921	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44922	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44923	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44924	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GAAAGGGGATGTATCCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44925	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44926	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44927	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44928	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44929	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44930	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44931	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44932	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44933	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44934	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44935	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44936	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44937	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44938	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44939	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44940	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CCTTAATTCCCACAATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44941	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44942	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44943	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44944	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44945	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44946	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44947	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44948	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44949	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44950	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44951	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44952	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44953	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44954	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44955	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44956	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GAGGCAATTGGGATGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44957	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44958	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44959	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44960	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44961	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44962	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44963	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44964	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44965	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44966	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44967	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44968	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44969	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44970	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44971	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44972	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CCCCAGCTGTGGGTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44973	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44974	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44975	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44976	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44977	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44978	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44979	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44980	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44981	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44982	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44983	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	44984	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	44985	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	44986	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	44987	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	44988	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GATCTGTTGTGTACGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44989	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44990	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44991	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44992	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44993	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44994	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44995	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44996	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44997	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44998	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	44999	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45000	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45001	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45002	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45003	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45004	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				TTTCTCTCTCGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45005	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45006	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45007	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45008	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45009	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45010	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45011	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45012	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45013	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45014	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45015	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45016	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45017	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45018	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45019	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45020	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				AATATTTAACATTAAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45021	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45022	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45023	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45024	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45025	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45026	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45027	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45028	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45029	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45030	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45031	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45032	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45033	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45034	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45035	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45036	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				TCAGTGCTGACTCAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45037	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45038	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45039	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45040	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45041	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45042	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45043	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45044	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45045	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45046	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45047	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45048	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45049	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45050	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45051	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45052	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CCAGGCACAGCGAGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45053	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45054	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45055	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45056	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45057	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45058	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45059	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45060	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45061	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45062	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45063	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45064	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45065	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45066	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45067	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45068	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GGTAAAGGTGGTGAGTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45069	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45070	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45071	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45072	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45073	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45074	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45075	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45076	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45077	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45078	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45079	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45080	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45081	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45082	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45083	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45084	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GTTACTCTGTACCACGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45085	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45086	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45087	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45088	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45089	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45090	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45091	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45092	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45093	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45094	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45095	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45096	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45097	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45098	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45099	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45100	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GATTGTAAATGGAACGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45101	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45102	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45103	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45104	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45105	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45106	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45107	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45108	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45109	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45110	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45111	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45112	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45113	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45114	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45115	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45116	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				AAGAACCTCTGGGGATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45117	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45118	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45119	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45120	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45121	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45122	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45123	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45124	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45125	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45126	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45127	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45128	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45129	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45130	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45131	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45132	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GACAACAGGGCCCAGGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45133	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45134	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45135	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45136	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45137	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45138	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45139	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45140	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45141	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45142	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45143	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45144	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45145	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45146	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45147	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45148	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				AGAAGTCCAAGGACACAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45149	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45150	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45151	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45152	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45153	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45154	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45155	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45156	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45157	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45158	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45159	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45160	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45161	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45162	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45163	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45164	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				TGCCCAGGAAAGGGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45165	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45166	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45167	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45168	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45169	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45170	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45171	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45172	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45173	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45174	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45175	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45176	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45177	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45178	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45179	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45180	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CCGGTGGCGCCACACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45181	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45182	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45183	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45184	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45185	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45186	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45187	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45188	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45189	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45190	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45191	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45192	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45193	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45194	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45195	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45196	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				TCTCGGAAGGCATTTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45197	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45198	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45199	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45200	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45201	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45202	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45203	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45204	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45205	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45206	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45207	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45208	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45209	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45210	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45211	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45212	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				ATTGGGCTGGCCGCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45213	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45214	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45215	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45216	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45217	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45218	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45219	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45220	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45221	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45222	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45223	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45224	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45225	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45226	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45227	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45228	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				GTCTGCTTGCAGACAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45229	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45230	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45231	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45232	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45233	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					FAM187A	chr17	44903432	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45234	hg19	N/A	enh32205	N/A	Enhatls77147	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					CCDC103	chr17	44899141	44905390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45235	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45236	hg19	N/A	enh32205	N/A	Enhatls77148	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45237	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45238	hg19	N/A	enh32205	N/A	Enhatls77149	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71887	chr17	42975202	43001013	44897834	44923645	45239	hg19	N/A	enh32205	N/A	N/A	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5156
enhrx-71888	chr17	42975202	43001013	44897834	44923645	45240	hg19	N/A	N/A	N/A	Enhatls77150	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5157
enhrx-71889	chr17	42975202	43001013	44897834	44923645	45241	hg19	N/A	N/A	N/A	Enhatls77151	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5158
enhrx-71890	chr17	42975202	43001013	44897834	44923645	45242	hg19	N/A	N/A	N/A	Enhatls77152	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5159
enhrx-71891	chr17	42975202	43001013	44897834	44923645	45243	hg19	N/A	N/A	N/A	Enhatls77153	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					GFAP	chr17	44903158	44916937	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5160
enhrx-71892	chr17	42975202	43001013	44897834	44923645	45244	hg19	N/A	N/A	N/A	Enhatls77154	enhancer	E_426				CTGCTCTGACAGAGGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KIF18B	chr17	44924708	44947773	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5161
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45245	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45246	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45247	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45248	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45249	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45250	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45251	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45252	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45253	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45254	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				AGAGCAGCAACTGCACCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45255	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45256	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45257	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45258	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45259	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45260	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45261	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45262	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45263	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45264	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				GGGCCATGCCAGGCGGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45265	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45266	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45267	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45268	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45269	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45270	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45271	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45272	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45273	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45274	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				TGAGCTAGAACTCCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45275	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45276	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45277	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45278	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45279	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45280	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45281	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45282	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45283	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45284	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				GAGCCTGGTGTGCTCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45285	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45286	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45287	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45288	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45289	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45290	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45291	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45292	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45293	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45294	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				CGATGACTCATCCAACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45295	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45296	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45297	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45298	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45299	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45300	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45301	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45302	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45303	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45304	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				TTTGTGCCCCTGAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45305	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45306	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45307	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45308	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45309	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45310	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45311	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45312	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45313	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45314	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				GGGACACTTTGGCCTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45315	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45316	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45317	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45318	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45319	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45320	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45321	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45322	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45323	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45324	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				CCAGATAGAATTAGGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45325	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45326	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45327	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45328	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45329	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45330	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45331	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45332	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45333	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45334	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				AAAGTGTTAGGGCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45335	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45336	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45337	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45338	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45339	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45340	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45341	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45342	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45343	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45344	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				AGCGTGTGGGGAGGACGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45345	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45346	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45347	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45348	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45349	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45350	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45351	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45352	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45353	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45354	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				TCAGCTTATTCACGCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45355	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45356	hg19	N/A	enh4428	fant52801	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45357	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45358	hg19	N/A	enh4428	fant52802	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45359	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45360	hg19	N/A	enh4428	fant52803	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45361	hg19	N/A	enh4428	N/A	Enhatls77222	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45362	hg19	N/A	enh4428	N/A	N/A	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45363	hg19	N/A	enh4428	N/A	Enhatls77223	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	5036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71948	chr17	43368172	43400900	45290806	45323534	45364	hg19	N/A	N/A	N/A	Enhatls77223	enhancer	E_427				GGCTTATGGGTGAGCCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					MAP3K14	chr17	45263118	45317029	6484				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5217
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45365	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CACCGGGCAAGATTGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45366	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CACCGGGCAAGATTGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45367	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CTACACTGGTACAAATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45368	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CTACACTGGTACAAATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45369	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CCAGATTTATAGGAGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45370	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CCAGATTTATAGGAGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45371	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CACGAGTGAGCAAAGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45372	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CACGAGTGAGCAAAGGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45373	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGTACCTGGAGTGCTGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45374	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGTACCTGGAGTGCTGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45375	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGGCAGCCACCTGGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45376	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGGCAGCCACCTGGCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45377	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				TGCCCATCCTGGGCGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45378	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				TGCCCATCCTGGGCGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45379	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				AGCGGAACCCCGGATGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45380	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				AGCGGAACCCCGGATGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45381	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CAGGCCGACCAAGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45382	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CAGGCCGACCAAGCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45383	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CCGGGAAGGGGCGGGCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45384	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CCGGGAAGGGGCGGGCGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45385	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGGAGAAGGCTCAATCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45386	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGGAGAAGGCTCAATCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45387	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				CATCTCGTTTCTTCCGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45388	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				CATCTCGTTTCTTCCGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45389	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGTGGCGCAGCGGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45390	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGTGGCGCAGCGGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45391	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGTTGAGAGAGACGCGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45392	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGTTGAGAGAGACGCGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45393	hg19	N/A	enh4433	fant52806	Enhatls77253	enhancer	E_428				GGCTGGAGCCCAAAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	36537				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-71977	chr17	43660946	43664199	45583580	45586833	45394	hg19	N/A	enh4433	N/A	Enhatls77253	enhancer	E_428				GGCTGGAGCCCAAAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					LINC02210-CRHR1	chr17	45620343	45835826	31670				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5246
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45395	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				AAATTTATGTTAATACATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45396	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				ACATGCCAGAAAAACCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45397	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				TTAAAAGGAAAGAATCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45398	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				AACAGTCATTTTACTTTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45399	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				ACTGGTAGATAAATTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45400	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				TAAAAGTTATCTAAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45401	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				GGTAAGAGTTAGGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45402	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				TTTCACACTGCTTTTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45403	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				GATGTTGTTCTTATTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45404	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				GAATAACAATTTAGTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72027	chr17	44176790	44181274	46099424	46103908	45405	hg19	N/A	enh4434	N/A	Enhatls77302	enhancer	E_429				CAGGCGCGTGCTACTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5296
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45406	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CTGGGAGTCGCCCCAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45407	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTGGGAGTCGCCCCAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45408	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CTGGGAGTCGCCCCAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45409	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTGGGAGTCGCCCCAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45410	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				TAGTTGTAACTAGAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45411	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				TAGTTGTAACTAGAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45412	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				TAGTTGTAACTAGAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45413	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				TAGTTGTAACTAGAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45414	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				AGAGAGAAATGGGAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45415	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AGAGAGAAATGGGAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45416	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				AGAGAGAAATGGGAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45417	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AGAGAGAAATGGGAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45418	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GGCTACGCTCCTCCATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45419	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGCTACGCTCCTCCATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45420	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GGCTACGCTCCTCCATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45421	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGCTACGCTCCTCCATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45422	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GCCGAGGGCCAGCGGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45423	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCCGAGGGCCAGCGGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45424	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GCCGAGGGCCAGCGGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45425	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCCGAGGGCCAGCGGCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45426	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CGCCCTGACTTTCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45427	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CGCCCTGACTTTCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45428	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CGCCCTGACTTTCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45429	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CGCCCTGACTTTCCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45430	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GGCCTTGCTCCGCACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45431	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGCCTTGCTCCGCACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45432	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GGCCTTGCTCCGCACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45433	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGCCTTGCTCCGCACCGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	direct	Highly Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45434	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GTGCGGGTTCGGGCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45435	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GTGCGGGTTCGGGCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45436	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GTGCGGGTTCGGGCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45437	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GTGCGGGTTCGGGCTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45438	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GAAGCCGACTCGTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45439	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GAAGCCGACTCGTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45440	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GAAGCCGACTCGTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45441	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GAAGCCGACTCGTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45442	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CTCCGCTTCAGATTAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45443	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTCCGCTTCAGATTAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45444	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CTCCGCTTCAGATTAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45445	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTCCGCTTCAGATTAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45446	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GGGCGAGCGCCGGGGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45447	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGGCGAGCGCCGGGGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45448	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GGGCGAGCGCCGGGGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45449	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GGGCGAGCGCCGGGGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45450	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CGCCCCCGCGGGCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45451	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CGCCCCCGCGGGCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45452	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CGCCCCCGCGGGCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45453	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CGCCCCCGCGGGCCGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45454	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GTGCCGTCGCCGCACGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45455	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GTGCCGTCGCCGCACGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45456	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GTGCCGTCGCCGCACGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45457	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GTGCCGTCGCCGCACGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45458	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				ACCGCCGGCCCCAGCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45459	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				ACCGCCGGCCCCAGCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45460	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				ACCGCCGGCCCCAGCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45461	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				ACCGCCGGCCCCAGCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45462	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GCTCACGTCCTCTCGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45463	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCTCACGTCCTCTCGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45464	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GCTCACGTCCTCTCGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45465	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCTCACGTCCTCTCGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45466	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GCTTTCTGCAGGGTTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45467	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCTTTCTGCAGGGTTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45468	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GCTTTCTGCAGGGTTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45469	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GCTTTCTGCAGGGTTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45470	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				AGCCGTGCTGCAGTATACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45471	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AGCCGTGCTGCAGTATACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45472	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				AGCCGTGCTGCAGTATACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45473	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AGCCGTGCTGCAGTATACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45474	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CACCAGAGTTGGGCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45475	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CACCAGAGTTGGGCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45476	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CACCAGAGTTGGGCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45477	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CACCAGAGTTGGGCGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45478	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				AAGGGACAGCCGGGAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45479	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AAGGGACAGCCGGGAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45480	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				AAGGGACAGCCGGGAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45481	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				AAGGGACAGCCGGGAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45482	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				GATCCGCCAAAACAGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45483	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GATCCGCCAAAACAGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45484	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				GATCCGCCAAAACAGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45485	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				GATCCGCCAAAACAGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72028	chr17	44267316	44272473	46189950	46195107	45486	hg19	N/A	enh4436	N/A	N/A	enhancer	E_430				CTGGTAACGAGGTGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5297
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45487	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTGGTAACGAGGTGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45488	hg19	N/A	enh4437	fant52827	N/A	enhancer	E_430				CTGGTAACGAGGTGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72029	chr17	44267316	44272473	46189950	46195107	45489	hg19	N/A	enh4437	N/A	N/A	enhancer	E_430				CTGGTAACGAGGTGGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP3K14	indirect	Non Significant	NA					KANSL1	chr17	46029915	46225389	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5298
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45490	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				AGGCCTGTGTGGCTATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45491	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				GGGCGCAGATGGATGATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45492	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				ATAAATGCAGAGAAGCACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45493	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				CAGGTTAAGTGATAGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45494	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				CAGAAGGACTCATGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45495	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				GTTACTGTGAGGCCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45496	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				TGGCAGCAAATGACGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45497	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				CGGTTAGGTCAGGTGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72090	chr17	44818742	44821649	46741376	46744283	45498	hg19	N/A	enh4438	N/A	Enhatls77365	enhancer	E_431				AAGCAAGCATCTGAACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					NSF	chr17	46590668	46757679	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5359
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45499	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				GATCTTTGAACCCCAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45500	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				ACAGCAGGCCCAAAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45501	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				AGAATTTCGATCCCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45502	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				CCTTGGGCAACAGGAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45503	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				CATTATCAAGCTATTTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45504	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				TACGAACAATTCCTTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45505	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				CAGCCCCCTAGAAGAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72094	chr17	44840474	44844604	46763108	46767238	45506	hg19	N/A	N/A	N/A	Enhatls77369	enhancer	E_432				GCCTGGCTGCGCCCAAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5363
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45507	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45508	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45509	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45510	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45511	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45512	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45513	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45514	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGACCCTGGGACAGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45515	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45516	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45517	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45518	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45519	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45520	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45521	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45522	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGACGATGACCGTTGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45523	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45524	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45525	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45526	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45527	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45528	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45529	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45530	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGACATTGACGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	indirect	Non Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45531	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45532	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45533	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45534	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45535	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45536	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45537	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45538	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GGTGACTCGCCACCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45539	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45540	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45541	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45542	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45543	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45544	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45545	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45546	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ACTCGGCCCACAGCCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45547	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45548	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45549	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45550	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45551	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45552	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45553	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45554	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCGTCCCACTTCCAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45555	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45556	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45557	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45558	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45559	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45560	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45561	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45562	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				ATTGGGGCGAGTGAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45563	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45564	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45565	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45566	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45567	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45568	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45569	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45570	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGCCTGCGGCCTCTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45571	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45572	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45573	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45574	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45575	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45576	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45577	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45578	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TTCCCAGCCCCGGGAACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45579	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45580	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45581	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45582	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45583	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45584	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45585	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45586	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				TGTGCCTTCCCCGTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45587	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45588	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45589	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45590	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45591	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45592	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45593	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45594	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGCCACCGCGTAGCAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45595	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45596	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45597	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45598	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45599	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45600	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45601	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45602	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CGGGGGGCGCCGCTTCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45603	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45604	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45605	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45606	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45607	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45608	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45609	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45610	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				AGGGCGTGTGAATGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45611	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45612	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45613	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45614	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45615	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45616	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45617	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45618	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				CCCCGCCTGGGGAAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45619	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45620	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45621	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45622	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45623	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45624	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45625	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45626	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTCTTCCGCGAGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45627	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45628	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45629	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45630	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45631	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45632	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45633	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45634	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GCCCCGCGCTTTGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45635	hg19	N/A	enh91164	N/A	N/A	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45636	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45637	hg19	N/A	enh91164	fant52831	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45638	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45639	hg19	N/A	enh91164	fant52832	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45640	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45641	hg19	N/A	enh91164	fant52833	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72095	chr17	44847198	44849753	46769832	46772387	45642	hg19	N/A	enh91164	N/A	Enhatls77371	enhancer	E_433				GTGGTGTGGGGACTCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5364
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45643	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				GGGAGTGAGACATGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45644	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				GGGGAGCCCCAGAAGTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45645	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				CTGGTCTTCTCAGACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45646	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				GCCTGGTTAAAAGCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45647	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				TCACCCACTGCCCCTTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45648	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				CTCAAAGCCAGCCCCACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45649	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				GTGTGTGTGTGAGAGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45650	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				GGAAATCCATGGTACTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72096	chr17	44871176	44874147	46793810	46796781	45651	hg19	N/A	enh86252	N/A	Enhatls77372	enhancer	E_434				AAAAGAACTGATCAGGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB3	direct	Highly Significant	NA					WNT3	chr17	46762505	46833084	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5365
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45652	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				TACAGATGGGAAAATCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45653	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				TACAGATGGGAAAATCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45654	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				GTAGCTCTACAGTTCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45655	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				GTAGCTCTACAGTTCCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45656	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				TGATGACACTCTGCTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45657	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				TGATGACACTCTGCTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45658	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				ACGGTGTTGGAGATGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45659	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				ACGGTGTTGGAGATGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45660	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				GTCAAACGTGGGCGTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45661	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				GTCAAACGTGGGCGTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45662	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				CAAAAACTCCATTTGTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45663	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				CAAAAACTCCATTTGTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45664	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				TCATTGCAAAACCTTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45665	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				TCATTGCAAAACCTTTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45666	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				CCCACTCAACCTCAGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45667	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				CCCACTCAACCTCAGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45668	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				CTAAGGCTGACTGTAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45669	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				CTAAGGCTGACTGTAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45670	hg19	N/A	enh4443	N/A	Enhatls77415	enhancer	E_435				GTGTTTAGAACCTCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	2131				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45306730	45311255	47229364	47233889	45671	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_435				GTGTTTAGAACCTCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45672	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				GTGCAGGCAAAGAGTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45673	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTGCAGGCAAAGAGTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45674	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				GTGCAGGCAAAGAGTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45675	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTGCAGGCAAAGAGTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45676	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				AGAGTAACTGCCCAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45677	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				AGAGTAACTGCCCAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45678	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				AGAGTAACTGCCCAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45679	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				AGAGTAACTGCCCAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45680	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				GTATCTGAGTCCCTGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45681	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTATCTGAGTCCCTGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45682	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				GTATCTGAGTCCCTGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45683	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTATCTGAGTCCCTGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45684	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				CAGAGGAGCGCTCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45685	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CAGAGGAGCGCTCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45686	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				CAGAGGAGCGCTCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45687	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CAGAGGAGCGCTCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45688	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				GTTGGAAACACATAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45689	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTTGGAAACACATAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45690	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				GTTGGAAACACATAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45691	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GTTGGAAACACATAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45692	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				CAAGGTCTGAGCTAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45693	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CAAGGTCTGAGCTAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45694	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				CAAGGTCTGAGCTAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45695	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CAAGGTCTGAGCTAAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45696	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				GGAAATAGAGCAGCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45697	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GGAAATAGAGCAGCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45698	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				GGAAATAGAGCAGCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45699	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GGAAATAGAGCAGCCCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45700	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				TGGGTGCCTCCTCAGGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45701	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				TGGGTGCCTCCTCAGGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45702	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				TGGGTGCCTCCTCAGGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45703	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				TGGGTGCCTCCTCAGGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45704	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				CCAATTTTATCTCAGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45705	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CCAATTTTATCTCAGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45706	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				CCAATTTTATCTCAGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45707	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CCAATTTTATCTCAGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45708	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				CTTACAGTAAGGGAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45709	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CTTACAGTAAGGGAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45710	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				CTTACAGTAAGGGAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45711	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				CTTACAGTAAGGGAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45712	hg19	N/A	N/A	N/A	Enhatls77415	enhancer	E_436				GGGAGTTAGTGGCAAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					MYL4	chr17	47209034	47223679	9911				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45713	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GGGAGTTAGTGGCAAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13805				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45714	hg19	N/A	enh4444	fant52847	Enhatls77415	enhancer	E_436				GGGAGTTAGTGGCAAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	13301				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72136	chr17	45314870	45320352	47237504	47242986	45715	hg19	N/A	enh4444	N/A	Enhatls77415	enhancer	E_436				GGGAGTTAGTGGCAAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	5438				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5405
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45716	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45717	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45718	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45719	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45720	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45721	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45722	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45723	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45724	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45725	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45726	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				AGCGAGACTTGACTGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45727	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45728	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45729	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45730	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45731	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45732	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45733	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45734	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45735	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45736	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45737	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				TGTCTGACAGATCTCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45738	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45739	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45740	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45741	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45742	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45743	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45744	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45745	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45746	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45747	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45748	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				GCACCCTTCCAGCAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45749	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45750	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45751	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45752	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45753	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45754	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45755	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45756	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45757	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45758	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45759	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				TTTAAGGGCTAACCCTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45760	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45761	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45762	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45763	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45764	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45765	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45766	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45767	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45768	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45769	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45770	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				CACTTTGTTTAGCCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45771	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45772	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45773	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45774	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45775	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45776	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45777	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45778	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45779	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45780	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45781	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				TGGGAAAGACCGACACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45782	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45783	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45784	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45785	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45786	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45787	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45788	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45789	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45790	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45791	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45792	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				AGGGTGTAGTGAAAGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45793	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45794	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45795	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45796	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45797	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45798	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45799	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45800	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45801	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45802	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45803	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				TCGGCCAACCTCACAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45804	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45805	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45806	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45807	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45808	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45809	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45810	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45811	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45812	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45813	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45814	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				AGACAGCTCCTGTCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45815	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45816	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45817	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45818	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45819	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45820	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45821	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45822	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45823	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45824	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45825	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				CTTTGTGGTGCCATTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45826	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45827	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45828	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45829	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45830	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45831	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45832	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45833	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45834	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45835	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45836	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				GGGAAACAGGACATGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72139	chr17	45363093	45377479	47285727	47300113	45837	hg19	N/A	N/A	N/A	Enhatls77419	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5408
enhrx-72140	chr17	45363093	45377479	47285727	47300113	45838	hg19	N/A	N/A	N/A	Enhatls77420	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5409
enhrx-72141	chr17	45363093	45377479	47285727	47300113	45839	hg19	N/A	N/A	N/A	Enhatls77421	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5410
enhrx-72142	chr17	45363093	45377479	47285727	47300113	45840	hg19	N/A	N/A	N/A	Enhatls77422	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5411
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45841	hg19	N/A	N/A	N/A	Enhatls77423	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45842	hg19	hs2033	N/A	N/A	Enhatls77423	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72143	chr17	45363093	45377479	47285727	47300113	45843	hg19	hs2033	N/A	N/A	N/A	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45844	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45845	hg19	N/A	enh99423	N/A	Enhatls77424	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72144	chr17	45363093	45377479	47285727	47300113	45846	hg19	N/A	N/A	N/A	Enhatls77424	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5413
enhrx-72145	chr17	45363093	45377479	47285727	47300113	45847	hg19	N/A	N/A	N/A	Enhatls77425	enhancer	E_437				GGTTCCCTAGAAGTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					ITGB3	chr17	47253826	47313743	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5414
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45848	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45849	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45850	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45851	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45852	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45853	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45854	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45855	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				ACATGACTAAGCCTGGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45856	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45857	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45858	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45859	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45860	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45861	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45862	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45863	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				ACACAATTAGCCTAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45864	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45865	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45866	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45867	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45868	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45869	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45870	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45871	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GTTTTCTTTTAGCCTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45872	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45873	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45874	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45875	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45876	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45877	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45878	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45879	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GGTTATGAAAAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45880	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45881	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45882	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45883	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45884	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45885	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45886	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45887	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				TGGATGGTACGCTCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45888	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45889	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45890	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45891	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45892	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45893	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45894	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45895	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GTGAGGCCTTCCGCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45896	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45897	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45898	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45899	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45900	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45901	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45902	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45903	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GCTTCGCTGCAGGGATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45904	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45905	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45906	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45907	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45908	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45909	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45910	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45911	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GTCTTCTTTCAAACCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45912	hg19	N/A	enh86253	N/A	Enhatls77475	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45913	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45914	hg19	N/A	enh86253	N/A	Enhatls77476	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45915	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45916	hg19	N/A	enh86253	N/A	Enhatls77477	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45917	hg19	N/A	enh86253	N/A	N/A	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45918	hg19	N/A	enh86253	N/A	Enhatls77478	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72187	chr17	45695502	45700338	47618136	47622972	45919	hg19	N/A	N/A	N/A	Enhatls77478	enhancer	E_438				GAATTAAATTCTATTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					NPEPPS	chr17	47522941	47624665	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5456
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45920	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				GCTTCCCATGAGGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45921	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				GCTTCCCATGAGGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45922	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				TCACTTGCAACCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45923	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				TCACTTGCAACCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45924	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				AGTCTGTTCCAGCTCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45925	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				AGTCTGTTCCAGCTCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45926	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				TATTCCCACCACCTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45927	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				TATTCCCACCACCTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45928	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				CAGTGAGTGCCAGTCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45929	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				CAGTGAGTGCCAGTCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45930	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				GGTGGAGTTGTACAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45931	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				GGTGGAGTTGTACAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45932	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				GGCAGCTTTGAGGTCGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45933	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				GGCAGCTTTGAGGTCGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45934	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				GATGGTTTCCTGGCTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45935	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				GATGGTTTCCTGGCTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45936	hg19	N/A	enh91167	N/A	Enhatls77506	enhancer	E_439				TATAATCTGTGTACTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72209	chr17	45783250	45785625	47705884	47708259	45937	hg19	N/A	N/A	N/A	Enhatls77506	enhancer	E_439				TATAATCTGTGTACTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					TBKBP1	chr17	47694160	47712052	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5478
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45938	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				TGAAAGTTCTCAAACTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45939	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				TCCCGGCCCTGTGGGGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45940	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				GAGGGGGAGGCTCTATCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45941	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				ACTGGCGTCCATGGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45942	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				CACTGCTCAGCGCGGTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45943	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				CCCGGAGCTTGGCGGGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45944	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				GTGGGGGCACAGTCCCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45945	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				AACTGTTGGCTGTACGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45946	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				AGATGTAAAATGAGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45947	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				GCACTCTCTTATGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45948	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				GTGGGGCATCACCCCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72226	chr17	45897897	45901893	47820531	47824527	45949	hg19	N/A	N/A	N/A	Enhatls77525	enhancer	E_440				ATCAGAGACTGCAGGCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					OSBPL7	chr17	47807371	47821794	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5495
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45950	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45951	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45952	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45953	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45954	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45955	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45956	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45957	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	45958	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	45959	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				TCTTGGCAAAGATCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45960	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45961	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45962	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45963	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45964	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45965	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45966	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45967	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	45968	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	45969	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				CACGGAGACAAAGCAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45970	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45971	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45972	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45973	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45974	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45975	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45976	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45977	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	45978	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	45979	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				TCGGGGCTGAGCCGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45980	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45981	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45982	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45983	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45984	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45985	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45986	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45987	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	45988	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	45989	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GCGCAAGGAAGACACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45990	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45991	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45992	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45993	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45994	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45995	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45996	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	45997	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	45998	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	45999	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GGACGGGTGTGCGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46000	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46001	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46002	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46003	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46004	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46005	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46006	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46007	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46008	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46009	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				CGAAGGGCCGGGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46010	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46011	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46012	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46013	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46014	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46015	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46016	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46017	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46018	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46019	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				CGGGTATCTGGGCATGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46020	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46021	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46022	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46023	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46024	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46025	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46026	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46027	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46028	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46029	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GCCAGGGCCGCCCCATTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46030	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46031	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46032	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46033	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46034	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46035	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46036	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46037	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46038	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46039	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				CACCACTTCCCGGAGCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46040	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46041	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46042	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46043	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46044	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46045	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46046	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46047	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46048	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46049	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GCCCATTTGAGGCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46050	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46051	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46052	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46053	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46054	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46055	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46056	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46057	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46058	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46059	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GAAAGGATCCCGCGTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46060	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					LRRC46	chr17	47831669	47837719	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46061	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46062	hg19	N/A	enh102569	N/A	Enhatls77527	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46063	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46064	hg19	N/A	enh102569	N/A	Enhatls77528	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46065	hg19	N/A	enh102569	N/A	N/A	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46066	hg19	N/A	enh102569	N/A	Enhatls77529	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72227	chr17	45914947	45919703	47837581	47842337	46067	hg19	N/A	N/A	N/A	Enhatls77529	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-72228	chr17	45914947	45919703	47837581	47842337	46068	hg19	N/A	N/A	N/A	Enhatls77530	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-72229	chr17	45914947	45919703	47837581	47842337	46069	hg19	N/A	N/A	N/A	Enhatls77531	enhancer	E_441				GAGGCGCAATCCCAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SCRN2	chr17	47837691	47841289	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46070	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				AATGCTCCAGGCACTACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46071	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				GCCTAGAACCCTGGCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46072	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				ATGCAAAGGGCCAGAACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46073	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				GGGCGCCCAGCGCCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46074	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				GGATGGGATGGAGCATGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46075	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				AAATGCCCAGAATGAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46076	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				GGCTGTACCAAGCACATGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72232	chr17	45940086	45940728	47862720	47863362	46077	hg19	N/A	enh17194	N/A	Enhatls77534	enhancer	E_442				GTAAGCTTCATGGAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP6	chr17	47844907	47855874	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5501
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46078	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CTCTGATTCTGATGCTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46079	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				TGACTAGGACCCTGAGATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46080	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GAGGTGGTGCAAGTGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46081	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GCAGCATCTCATCCTGAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46082	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				AACTGCGGTAATAGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46083	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GCAAGGATGGAATAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46084	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				TCATAGGGACCTTGGGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46085	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				AAGGAAACTAGGAAGCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46086	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CTTCCCAAATACATTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46087	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GGTTAGCCACAAGCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46088	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GTTTATCAGAGGCCCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46089	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GCTGAGTTCACTTCAAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46090	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CCAGCTTTCTAAGAGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46091	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GGGAAAAGAAAAATGGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46092	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CACTAGTCTCCCTTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46093	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GATCTCTTGCAGCTCAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46094	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CTCCACGTGCGTGTTAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46095	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				GCGAGAACAGAGGAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46096	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CACCCTGGACTTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46097	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CGGGCCACAGCCGGGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46098	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CGTTCGGGCGACCTGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46099	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CATGCGCAAGAGTTACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72240	chr17	46009122	46021545	47931756	47944179	46100	hg19	N/A	N/A	N/A	Enhatls77543	enhancer	E_443				CCCCGGAGTCATCTACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SP2	chr17	47896149	47928957	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5509
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46101	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				CGTGTTGGGCGATTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46102	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				CGTGTTGGGCGATTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46103	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				ATTAGAGAAACTGAATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46104	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				ATTAGAGAAACTGAATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46105	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				ATGGTAAAGCGACGCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46106	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				ATGGTAAAGCGACGCAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46107	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				GAAGACCCAGTGCCCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46108	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				GAAGACCCAGTGCCCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46109	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				CGGGAGGGGGTGCGCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46110	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				CGGGAGGGGGTGCGCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46111	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				CGAATGGCTGAGCTCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46112	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				CGAATGGCTGAGCTCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46113	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				AGTGGAGCGTAAACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46114	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				AGTGGAGCGTAAACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46115	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				GCCCGTTTGTGTCTAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46116	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				GCCCGTTTGTGTCTAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46117	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				CCAGCCTGAAGCGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46118	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				CCAGCCTGAAGCGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46119	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				GGTGTGCTGGGGACTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46120	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				GGTGTGCTGGGGACTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72246	chr17	46043470	46050819	47966104	47973453	46121	hg19	N/A	N/A	N/A	Enhatls77550	enhancer	E_444				TTGCTGGTCTGGATGTCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5515
enhrx-72247	chr17	46043470	46050819	47966104	47973453	46122	hg19	N/A	N/A	N/A	Enhatls77551	enhancer	E_444				TTGCTGGTCTGGATGTCGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5516
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46123	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46124	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46125	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46126	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46127	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46128	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46129	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46130	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46131	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46132	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46133	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46134	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				TGCTACATGCTGGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46135	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46136	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46137	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46138	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46139	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46140	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46141	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46142	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46143	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46144	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46145	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46146	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				GTTAGTCCAAGGATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46147	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46148	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46149	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46150	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46151	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46152	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46153	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46154	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46155	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46156	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46157	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46158	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				ACCAGCATATGTGGGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46159	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46160	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46161	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46162	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46163	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46164	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46165	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46166	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46167	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46168	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46169	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46170	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				TGAGTGAAAATTCATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46171	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46172	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46173	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46174	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46175	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46176	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46177	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46178	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46179	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46180	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46181	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46182	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				CAGGGAGCCTAGAGAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46183	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46184	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46185	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46186	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46187	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46188	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46189	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46190	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46191	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46192	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46193	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46194	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				ATATAATGAGAATGACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46195	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46196	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46197	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46198	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46199	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46200	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46201	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46202	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46203	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46204	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46205	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46206	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				TGGGATTATTGTAAAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46207	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46208	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46209	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46210	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46211	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46212	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46213	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46214	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46215	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46216	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46217	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46218	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				AGAAGGCTGAACAGGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46219	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46220	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46221	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46222	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46223	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46224	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46225	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46226	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46227	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46228	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46229	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46230	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				TTCATTGGAGAAGGACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46231	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46232	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46233	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46234	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46235	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46236	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46237	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46238	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46239	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46240	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46241	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46242	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				GGTTAGATGCTCTAAGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46243	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46244	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46245	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46246	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46247	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46248	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46249	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46250	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46251	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46252	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46253	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46254	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				GCAGCAAATAAGACAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46255	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46256	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46257	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46258	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46259	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46260	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46261	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46262	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46263	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46264	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46265	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46266	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				GTTGGTTTAGTCAGGGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	indirect	Non Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46267	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46268	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46269	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46270	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46271	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46272	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46273	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46274	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46275	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46276	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46277	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46278	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				TTGACCGATGAATTCCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46279	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46280	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46281	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46282	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46283	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46284	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46285	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46286	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46287	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46288	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46289	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46290	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				GTGTGCTTGGATTCGCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46291	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46292	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46293	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46294	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46295	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46296	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46297	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46298	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46299	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46300	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46301	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46302	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				CGGCGAGGCCTGGTAACTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46303	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	13794				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46304	hg19	N/A	enh4448	fant52874	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	17869				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46305	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	18073				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46306	hg19	N/A	enh4448	fant52875	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19467				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46307	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	19793				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46308	hg19	N/A	enh4448	fant52876	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46309	hg19	hs2777	enh4448	fant52876	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	20893				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46310	hg19	hs2777	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					CDK5RAP3	chr17	47967809	47981781	21135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46311	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19829				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46312	hg19	N/A	enh4448	fant52877	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	19591				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46313	hg19	N/A	enh4448	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	18837				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46074827	46085499	47997461	48008133	46314	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_445				CCCCAAAGAGCCCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	16814				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46315	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46316	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46317	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46318	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46319	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46320	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46321	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				TATTGGCTGGCAGGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46322	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46323	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46324	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46325	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46326	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46327	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46328	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				CAACAAGCAGAGCCAACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46329	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46330	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46331	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46332	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46333	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46334	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46335	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				TCTGGGTTTCAGACGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46336	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46337	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46338	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46339	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46340	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46341	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46342	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				AGGGTCGCCCACGAGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46343	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46344	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46345	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46346	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46347	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46348	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46349	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				TTTTCGGGAAGGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46350	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46351	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46352	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46353	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46354	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46355	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46356	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GCGCTAATGAGGCAGTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46357	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46358	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46359	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46360	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46361	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46362	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46363	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				CGGCGGCCCTCCACCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46364	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46365	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46366	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46367	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46368	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46369	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46370	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				AAGGGCGCTGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46371	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46372	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46373	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46374	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46375	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46376	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46377	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				CGCGGCTGCGAAGCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46378	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46379	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46380	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46381	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46382	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46383	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46384	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GGGGGCATGGCAATGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46385	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46386	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46387	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46388	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46389	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46390	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46391	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GGTTCGGATGGGCCTAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46392	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46393	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46394	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46395	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46396	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46397	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46398	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GGTGTAGTTTTCGCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46399	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46400	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46401	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46402	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46403	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46404	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46405	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GCGATGCTCTCCCCATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46406	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46407	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46408	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46409	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46410	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46411	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46412	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				AATGTAAAGGGACAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46413	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46414	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46415	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46416	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46417	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46418	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46419	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				ACATTGGAATAGCAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46420	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46421	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46422	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46423	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46424	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46425	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46426	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				GCAAATATGCGGCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46427	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	2182				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46428	hg19	N/A	enh4450	fant52880	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1953				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46429	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	1129				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46430	hg19	N/A	enh4450	fant52881	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	703				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46431	hg19	N/A	enh4450	N/A	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	98				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72254	chr17	46099695	46105058	48022329	48027692	46432	hg19	N/A	N/A	N/A	Enhatls77560	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5523
enhrx-72255	chr17	46099695	46105058	48022329	48027692	46433	hg19	N/A	N/A	N/A	Enhatls77561	enhancer	E_446				TTAAATTCCGTGGAGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5524
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46434	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				TCCTAGATAATGACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46435	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				TCCTAGATAATGACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46436	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GCTGTGGACCTTGAGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46437	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GCTGTGGACCTTGAGGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46438	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				TGTGCCACATGGGCCAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46439	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				TGTGCCACATGGGCCAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46440	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GAAGGACCTTCTGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46441	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GAAGGACCTTCTGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46442	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GACTGCTCCAGAGCCCGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46443	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GACTGCTCCAGAGCCCGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46444	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				TCTGGAGTCTACCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46445	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				TCTGGAGTCTACCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46446	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GGGTGAGTTGCGATTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46447	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GGGTGAGTTGCGATTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46448	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GTCCTGAGTCCGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46449	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GTCCTGAGTCCGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46450	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				CTCAGAACTCGCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46451	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				CTCAGAACTCGCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46452	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GCGGGCGCGGGGATCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46453	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GCGGGCGCGGGGATCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46454	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GGCGCCGCCTGCTCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46455	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GGCGCCGCCTGCTCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46456	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				TGTCAGTGCGAGGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46457	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				TGTCAGTGCGAGGCGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46458	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GCGTGGCCTCCCTTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46459	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GCGTGGCCTCCCTTTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46460	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				ATGCAGAGTTCGGGGATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46461	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				ATGCAGAGTTCGGGGATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46462	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				TGGTGTGCGCCAGTGTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46463	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				TGGTGTGCGCCAGTGTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72259	chr17	46114179	46116214	48036813	48038852	46464	hg19	N/A	N/A	N/A	Enhatls77565	enhancer	E_447				GTCCTCATGGTACCTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5528
enhrx-72260	chr17	46114179	46116214	48036813	48038852	46465	hg19	N/A	N/A	N/A	Enhatls77566	enhancer	E_447				GTCCTCATGGTACCTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					COPZ2	chr17	48026166	48038030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5529
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46466	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46467	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46468	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46469	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46470	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46471	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46472	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46473	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GGTTCTTCTCATACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46474	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46475	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46476	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46477	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46478	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46479	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46480	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46481	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				CCCATGTGTGAAGGGTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46482	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46483	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46484	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46485	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46486	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46487	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46488	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46489	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GATTGTGAACGAGTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46490	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46491	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46492	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46493	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46494	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46495	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46496	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46497	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				TTCCTTTGAAGACTTGGGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46498	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46499	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46500	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46501	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46502	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46503	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46504	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46505	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				TTTAGTCTCAGAGTACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46506	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46507	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46508	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46509	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46510	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46511	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46512	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46513	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				CAGCAAAGTGCTATTTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46514	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46515	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46516	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46517	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46518	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46519	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46520	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46521	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				ATCTTGGACCCAGAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46522	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46523	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46524	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46525	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46526	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46527	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46528	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46529	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				AATGCTGGAACACCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46530	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46531	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46532	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46533	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46534	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46535	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46536	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46537	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				AAGAGGCCTGATGAATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46538	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46539	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46540	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46541	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46542	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46543	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46544	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46545	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GGTGGTACTGAAGGGAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46546	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46547	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46548	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46549	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46550	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46551	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46552	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46553	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GCAGGCTTCAAGCTCAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46554	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46555	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46556	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46557	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46558	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46559	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46560	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46561	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				TTATCTGCATGATCCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46562	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46563	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46564	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46565	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46566	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46567	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46568	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46569	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				ATGTGGTTCTGCTTTCAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46570	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46571	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46572	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46573	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46574	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46575	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46576	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46577	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				TGGAGTTGACTGTATAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46578	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46579	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46580	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46581	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46582	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46583	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46584	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46585	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				AGGACTTTGTTACTGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46586	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46587	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46588	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46589	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46590	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46591	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46592	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46593	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				CCTCCTTTGCCCCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46594	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46595	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46596	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46597	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46598	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46599	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46600	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46601	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GATAACACTCCCCAAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46602	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46603	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46604	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46605	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46606	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46607	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46608	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46609	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GACTTGGTGGCTGTTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46610	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46611	hg19	N/A	enh17196	fant52889	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46612	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46613	hg19	N/A	enh17196	fant52890	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46614	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46615	hg19	N/A	enh17196	fant52891	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46616	hg19	N/A	enh17196	N/A	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46311725	46327384	48234363	48250022	46617	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_448				GCAAGTTTACTTCCTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46618	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				TTTCACAGAGATCTCATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46619	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				AATCGGATAGTACCAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46620	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				CGGAGTTTCACCCGATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46621	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				TTCTGTCGTTTGCAGTGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46622	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				GGAACACTCAGCTCAGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46623	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				ATGAAAAGTCTTCAGTGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-72288	chr17	46388155	46388994	48310793	48311632	46624	hg19	N/A	N/A	N/A	Enhatls77594	enhancer	E_449				GGGATGCCCAATGTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ITGB3,NFE2L1"	direct	Highly Significant	NA					SKAP1	chr17	48133441	48430219	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5557
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46625	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CTTCTCTTTCCACGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46626	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CTTCTCTTTCCACGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46627	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GCGGCGCAGCAGCAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46628	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GCGGCGCAGCAGCAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46629	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				ATACTGGGAACTGACGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46630	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				ATACTGGGAACTGACGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46631	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GGGGAAGCGTGGGAACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46632	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GGGGAAGCGTGGGAACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46633	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GCGGGGCGAAGGACGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46634	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GCGGGGCGAAGGACGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46635	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GAAGCGAGAAGGGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46636	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GAAGCGAGAAGGGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46637	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				AGGCGGGCGGTGAATGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46638	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				AGGCGGGCGGTGAATGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46639	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GGCGCGAGGCGAACGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46640	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GGCGCGAGGCGAACGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46641	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CAAAGACTGGACGCAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46642	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CAAAGACTGGACGCAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46643	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CGGAGGGGCGAAGGCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46644	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CGGAGGGGCGAAGGCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46645	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CGATGATGCAGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46646	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CGATGATGCAGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46647	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GCGGGAGGAAGACTCACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46648	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GCGGGAGGAAGACTCACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46649	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GCGGAGCGACAACTGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46650	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GCGGAGCGACAACTGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46651	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CCGCCGCAGCCCACATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46652	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CCGCCGCAGCCCACATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46653	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				CTGGAAATAGCGCAGCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46654	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				CTGGAAATAGCGCAGCATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46655	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				TCGAAAACCAAGTAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46656	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				TCGAAAACCAAGTAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46657	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				TGAGCGGACACCGCAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46658	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				TGAGCGGACACCGCAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79009	chr18	77793072	77794839	80033072	80034839	46659	hg19	N/A	N/A	fant55698	N/A	enhancer	E_453				GAACTGCTGCAGACCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					TXNL4A	chr18	79970812	80033949	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3027
enhrx-79010	chr18	77793072	77794839	80033072	80034839	46660	hg19	N/A	N/A	N/A	Enhatls84756	enhancer	E_453				GAACTGCTGCAGACCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HSBP1L1	direct	Highly Significant	NA					RBFA	chr18	80034433	80050651	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3028
enhrx-79068	chr19	382788	384368	382788	384368	46661	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				TAGGAGGTGGGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79068	chr19	382788	384368	382788	384368	46662	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				TAGGAGGTGGAGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79068	chr19	382788	384368	382788	384368	46663	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				TCACATTCCTATTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79068	chr19	382788	384368	382788	384368	46664	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				GTCCTTGCAAAAGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79068	chr19	382788	384368	382788	384368	46665	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				ACTCCAGATTAAGCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79068	chr19	382788	384368	382788	384368	46666	hg19	N/A	enh94982	N/A	Enhatls84818	enhancer	E_454				AGCTGTTGTGGACCGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SPMAP2	chr19	361746	376026	5917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	38
enhrx-79094	chr19	520990	525577	520990	525577	46667	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				TGTGGGCTTCGGGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46668	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				TGTGGGCTTCGGGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46669	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				GCGTCCCTGTCCGGGTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46670	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				GCGTCCCTGTCCGGGTGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46671	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				GTGCACCTCACACTCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46672	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				GTGCACCTCACACTCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46673	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				CGGCACAGGGTCAGGGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46674	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				CGGCACAGGGTCAGGGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46675	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				TGCCGGGATTAGGACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46676	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				TGCCGGGATTAGGACAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46677	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				AGGGAGGACGCGTCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46678	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				AGGGAGGACGCGTCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46679	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				TAGAGCGCGGCAATCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46680	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				TAGAGCGCGGCAATCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46681	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				GCCCTGGATGAAGCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46682	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				GCCCTGGATGAAGCCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46683	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				TCCAAGACGGAGCTTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46684	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				TCCAAGACGGAGCTTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46685	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				GTCTCAGTGCTCAGTGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46686	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				GTCTCAGTGCTCAGTGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46687	hg19	N/A	N/A	N/A	Enhatls84842	enhancer	E_455				AGGCAGGGTGCCTCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79094	chr19	520990	525577	520990	525577	46688	hg19	N/A	enh17833	N/A	Enhatls84842	enhancer	E_455				AGGCAGGGTGCCTCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					TPGS1	chr19	507496	519654	2392				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	64
enhrx-79101	chr19	555425	557400	555425	557400	46689	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTTTTTTGCTCTTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46690	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				GTTTTTTGCTCTTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46691	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTTTTTTGCTCTTGTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46692	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				CGGTGCCCTGTGACCTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46693	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				CGGTGCCCTGTGACCTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46694	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				CGGTGCCCTGTGACCTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46695	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				TTAGCTCTCTCCCCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46696	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				TTAGCTCTCTCCCCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46697	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				TTAGCTCTCTCCCCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46698	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GCCCGGACGTGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46699	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				GCCCGGACGTGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46700	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GCCCGGACGTGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46701	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTGTGGGACACGCAGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46702	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				GTGTGGGACACGCAGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46703	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTGTGGGACACGCAGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46704	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTTTGAGGCTGCAGTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46705	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				GTTTGAGGCTGCAGTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46706	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GTTTGAGGCTGCAGTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46707	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				CCATCTCCTCAGGAGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46708	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				CCATCTCCTCAGGAGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46709	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				CCATCTCCTCAGGAGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46710	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GGTCTCAGTATGTTGCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	2842				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46711	hg19	N/A	enh17834	fant55720	Enhatls84849	enhancer	E_456				GGTCTCAGTATGTTGCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6053				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79101	chr19	555425	557400	555425	557400	46712	hg19	N/A	enh17834	N/A	Enhatls84849	enhancer	E_456				GGTCTCAGTATGTTGCTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					GZMM	chr19	544033	549924	6399				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	71
enhrx-79114	chr19	609216	613047	609216	613047	46713	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GCCGGTCCCTGAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46714	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GCCGGTCCCTGAGGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46715	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GTGCAGAGGCTCACGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46716	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GTGCAGAGGCTCACGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46717	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GGTCTGTGCCTGACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46718	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GGTCTGTGCCTGACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46719	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				CCAGGACCTGGTGCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46720	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				CCAGGACCTGGTGCTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46721	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				TTGCGGGAACAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46722	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				TTGCGGGAACAAATACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46723	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				TCCGGGGGGGTAGCACGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46724	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				TCCGGGGGGGTAGCACGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46725	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				ATCTGCAAGCCAAGGGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46726	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				ATCTGCAAGCCAAGGGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46727	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GAGGCCACGAGGAACCGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46728	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GAGGCCACGAGGAACCGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46729	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				ATAGGACCTTATGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46730	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				ATAGGACCTTATGTGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46731	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GGACCTTCAAGCACACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46732	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GGACCTTCAAGCACACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46733	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				GATGGCGGCCGTGATCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46734	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				GATGGCGGCCGTGATCACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46735	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				CCGAGCCAGGTGCTACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46736	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				CCGAGCCAGGTGCTACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46737	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				CCCCCCCAGAGGCATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46738	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				CCCCCCCAGAGGCATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46739	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				TTAATTGCATTTGATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46740	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				TTAATTGCATTTGATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46741	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				ACAAAATGCATAAAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46742	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				ACAAAATGCATAAAATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46743	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				TCACTCCAGAACATTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46744	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				TCACTCCAGAACATTCTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46745	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				TAGCGTGGGTTGCCAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46746	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				TAGCGTGGGTTGCCAGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79114	chr19	609216	613047	609216	613047	46747	hg19	N/A	N/A	N/A	Enhatls84862	enhancer	E_457				CTTTAAACCCACATATGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	84
enhrx-79115	chr19	609216	613047	609216	613047	46748	hg19	N/A	N/A	N/A	Enhatls84863	enhancer	E_457				CTTTAAACCCACATATGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					HCN2	chr19	589880	617159	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	85
enhrx-79158	chr19	749705	755597	749705	755597	46749	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46750	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46751	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46752	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46753	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46754	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46755	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46756	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46757	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				GGCCCCAGAGTACCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46758	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46759	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46760	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46761	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46762	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46763	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46764	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46765	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46766	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				CTTGTCCCTGAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46767	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46768	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46769	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46770	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46771	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46772	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46773	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46774	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46775	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				CTCTGGAATTCCCAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46776	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46777	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46778	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46779	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46780	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46781	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46782	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46783	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46784	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				CTGGGCAGTAAACACCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46785	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46786	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46787	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46788	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46789	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46790	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46791	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46792	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46793	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				GTACAGGCGGAAGGAGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46794	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46795	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46796	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46797	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46798	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46799	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46800	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46801	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46802	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				CTCGGCCCAGCGTCTGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46803	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46804	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46805	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46806	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46807	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46808	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46809	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46810	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46811	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				GTGACTGCAACCCTGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46812	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46813	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46814	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46815	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46816	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46817	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46818	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46819	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46820	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				TCTGAGTCTCGGCCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46821	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46822	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46823	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46824	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46825	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46826	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46827	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46828	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46829	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				GTTGATACCAGAATGAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46830	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46831	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46832	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46833	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46834	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46835	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46836	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46837	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46838	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				TCCAAATCACCCCCTCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46839	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46840	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46841	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46842	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46843	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46844	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46845	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46846	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46847	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				TCGAAAACCGGAGTCGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46848	hg19	N/A	enh44618	N/A	N/A	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46849	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46850	hg19	N/A	enh44618	fant55727	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46851	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46852	hg19	N/A	enh44618	fant55728	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46853	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46854	hg19	N/A	enh44618	fant55729	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46855	hg19	N/A	enh44618	N/A	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79158	chr19	749705	755597	749705	755597	46856	hg19	N/A	N/A	N/A	Enhatls84912	enhancer	E_458				CGAGGTCCTTAGCCACCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	128
enhrx-79162	chr19	778973	785834	778973	785834	46857	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				GGGGCAGTGAGACGCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46858	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				GGGGCAGTGAGACGCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46859	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				CACTGCCGCTGACAGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46860	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				CACTGCCGCTGACAGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46861	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				CTTCTAAGACAAAACCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46862	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				CTTCTAAGACAAAACCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46863	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				TGACGTCTAGACCTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46864	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				TGACGTCTAGACCTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46865	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				TTCATCTCCAGGGTTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46866	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				TTCATCTCCAGGGTTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46867	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				AGGCGGTGTGTGAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46868	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				AGGCGGTGTGTGAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46869	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				GGGGTCCTCGAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46870	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				GGGGTCCTCGAGGAGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46871	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				TTAGCATATCACAGAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46872	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				TTAGCATATCACAGAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46873	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				ACTTTAAATTGGACTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46874	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				ACTTTAAATTGGACTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46875	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				GCGAGGTCCTCCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46876	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				GCGAGGTCCTCCTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46877	hg19	N/A	enh17836	N/A	Enhatls84916	enhancer	E_459				AACTGTGCTTGAAGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MISP	chr19	751111	764318	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79162	chr19	778973	785834	778973	785834	46878	hg19	N/A	N/A	N/A	Enhatls84916	enhancer	E_459				AACTGTGCTTGAAGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	10267				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	132
enhrx-79163	chr19	795191	801323	795191	801323	46879	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46880	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46881	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46882	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46883	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46884	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				AGTCGGGATTCGCTGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46885	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46886	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46887	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46888	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46889	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46890	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTCGCGTCCCGGACACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46891	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46892	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46893	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46894	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46895	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46896	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				TTTCCTGCCCGACTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46897	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46898	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46899	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46900	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46901	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46902	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTACGTGGCGAGTCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46903	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46904	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46905	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46906	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46907	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46908	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GAGAAAATGGGATCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46909	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46910	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46911	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46912	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46913	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46914	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGACCCAGAGAAATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46915	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46916	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46917	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46918	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46919	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46920	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GTTATAGACTCACAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46921	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46922	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46923	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46924	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46925	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46926	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				ACGTGCGACTCACCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46927	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46928	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46929	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46930	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46931	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46932	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GGGCGAGATCGGCCCCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46933	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46934	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46935	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46936	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46937	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46938	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCCCGCCACGCGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46939	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46940	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46941	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46942	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46943	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46944	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGGGTCAGGGGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46945	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46946	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46947	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46948	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46949	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46950	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCGAAGTGCGGGGACGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46951	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46952	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46953	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46954	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46955	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46956	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				GCACGAGGGGAGCGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46957	hg19	N/A	enh99530	fant55732	N/A	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	1852				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46958	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46959	hg19	N/A	enh99530	N/A	Enhatls84917	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46960	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46961	hg19	N/A	enh99530	fant55733	N/A	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79163	chr19	795191	801323	795191	801323	46962	hg19	N/A	enh99530	N/A	N/A	enhancer	E_460				CGCGCGTGCGCGGCCGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					PTBP1	chr19	797074	812327	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	133
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46963	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46964	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46965	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46966	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46967	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46968	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46969	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46970	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46971	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46972	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46973	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46974	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				TTACTGCCCGCCAGGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46975	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46976	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46977	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46978	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46979	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46980	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46981	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46982	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46983	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46984	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46985	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46986	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GATGTGCGCCAGGTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46987	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46988	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46989	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46990	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46991	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46992	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46993	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46994	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46995	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46996	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46997	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46998	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				CCAAGTGAAACCGAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	46999	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47000	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47001	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47002	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47003	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47004	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47005	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47006	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47007	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47008	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47009	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47010	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GAGGTCAATCACAAGGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47011	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47012	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47013	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47014	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47015	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47016	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47017	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47018	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47019	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47020	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47021	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47022	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				CGATCTGCTGACCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47023	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47024	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47025	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47026	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47027	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47028	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47029	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47030	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47031	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47032	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47033	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47034	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				CTGGACAACCCCATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47035	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47036	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47037	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47038	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47039	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47040	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47041	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47042	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47043	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47044	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47045	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47046	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GGGAATCCGCAGGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47047	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47048	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47049	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47050	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47051	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47052	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47053	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47054	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47055	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47056	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47057	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47058	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GCTCTCACGGGGCCTCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47059	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47060	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47061	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47062	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47063	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47064	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47065	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47066	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47067	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47068	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47069	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47070	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				AACCACTCACTGCTTCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47071	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47072	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47073	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47074	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47075	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47076	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47077	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47078	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47079	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47080	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47081	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47082	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				CTGGGCGAGGGGCCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47083	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47084	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47085	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47086	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47087	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47088	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47089	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47090	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47091	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47092	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47093	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47094	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				AGATTGCTCTGCCAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47095	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47096	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47097	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47098	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47099	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47100	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47101	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47102	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47103	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47104	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47105	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47106	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GGGGCGTTGGATCGTTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47107	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47108	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47109	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47110	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47111	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47112	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47113	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47114	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47115	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47116	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47117	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47118	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GTGGCCCTGGCACCTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47119	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47120	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47121	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47122	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47123	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47124	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47125	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47126	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47127	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47128	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47129	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47130	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GCCACGAAGAAGCCGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47131	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47132	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47133	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47134	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47135	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47136	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47137	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47138	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47139	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47140	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47141	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47142	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				ACCCTTGCCCTGCACTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47143	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47144	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47145	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47146	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47147	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47148	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47149	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47150	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47151	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47152	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47153	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47154	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GCTGCCCTGAGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47155	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47156	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47157	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47158	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47159	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47160	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47161	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47162	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47163	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47164	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47165	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47166	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				GGCTTCTCTGGAATTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47167	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47168	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47169	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47170	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47171	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47172	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47173	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47174	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47175	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47176	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47177	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47178	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				ACAGTTCTCCAAATGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47179	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47180	hg19	N/A	enh17838	fant55765	Enhatls85106	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47181	hg19	N/A	enh17838	N/A	Enhatls85106	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47182	hg19	N/A	N/A	N/A	Enhatls85106	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47183	hg19	N/A	enh17839	N/A	Enhatls85106	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47184	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47185	hg19	N/A	enh17839	fant55766	N/A	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					SBNO2	chr19	1107636	1174268	1166				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47186	hg19	N/A	enh17839	N/A	N/A	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47187	hg19	N/A	enh17839	N/A	Enhatls85107	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47188	hg19	N/A	enh17839	fant55767	Enhatls85107	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47189	hg19	N/A	N/A	fant55767	Enhatls85107	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79317	chr19	1165197	1185934	1165198	1185935	47190	hg19	N/A	N/A	N/A	Enhatls85107	enhancer	E_462				AAGTTTTCCCCAAGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					STK11	chr19	1177557	1228431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	287
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47191	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47192	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47193	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47194	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47195	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47196	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47197	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47198	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47199	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47200	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47201	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47202	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47203	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47204	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47205	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GCTGGGATCTCAGGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47206	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47207	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47208	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47209	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47210	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47211	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47212	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47213	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47214	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47215	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47216	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47217	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47218	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47219	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47220	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CAGCACGCGTGCCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47221	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47222	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47223	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47224	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47225	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47226	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47227	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47228	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47229	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47230	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47231	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47232	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47233	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47234	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47235	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CACATATGCTCTGTGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47236	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47237	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47238	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47239	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47240	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47241	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47242	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47243	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47244	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47245	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47246	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47247	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47248	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47249	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47250	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GGCGCTGTGTGTGCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47251	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47252	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47253	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47254	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47255	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47256	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47257	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47258	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47259	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47260	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47261	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47262	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47263	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47264	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47265	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TCGGTGCGCAGGGCATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47266	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47267	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47268	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47269	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47270	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47271	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47272	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47273	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47274	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47275	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47276	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47277	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47278	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47279	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47280	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GTGGCGCACATGTGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47281	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47282	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47283	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47284	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47285	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47286	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47287	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47288	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47289	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47290	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47291	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47292	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47293	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47294	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47295	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CCAGCTGGCCCCACTACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47296	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47297	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47298	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47299	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47300	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47301	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47302	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47303	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47304	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47305	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47306	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47307	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47308	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47309	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47310	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				ATTTCTGCGCCCCCGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47311	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47312	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47313	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47314	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47315	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47316	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47317	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47318	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47319	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47320	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47321	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47322	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47323	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47324	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47325	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GCCTGCGACGGGCGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47326	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47327	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47328	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47329	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47330	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47331	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47332	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47333	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47334	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47335	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47336	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47337	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47338	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47339	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47340	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				AGGACCTGGCGTCCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47341	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47342	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47343	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47344	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47345	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47346	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47347	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47348	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47349	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47350	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47351	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47352	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47353	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47354	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47355	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TCCCCTGCGGGGCGTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47356	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47357	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47358	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47359	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47360	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47361	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47362	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47363	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47364	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47365	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47366	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47367	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47368	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47369	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47370	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GGTGCGCGCCCCTTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47371	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47372	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47373	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47374	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47375	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47376	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47377	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47378	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47379	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47380	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47381	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47382	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47383	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47384	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47385	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CGGGGCCCAAGACAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47386	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47387	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47388	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47389	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47390	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47391	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47392	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47393	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47394	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47395	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47396	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47397	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47398	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47399	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47400	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GCTATTCCGGGCCCGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47401	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47402	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47403	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47404	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47405	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47406	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47407	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47408	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47409	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47410	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47411	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47412	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47413	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47414	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47415	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CCGCGCCTCGGCCCCAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47416	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47417	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47418	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47419	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47420	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47421	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47422	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47423	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47424	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47425	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47426	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47427	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47428	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47429	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47430	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GGCCTGAGGCCTGGGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47431	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47432	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47433	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47434	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47435	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47436	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47437	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47438	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47439	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47440	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47441	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47442	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47443	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47444	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47445	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TGGTCACGCCCCCTCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47446	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47447	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47448	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47449	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47450	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47451	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47452	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47453	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47454	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47455	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47456	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47457	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47458	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47459	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47460	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TCGAGCCCGACACCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47461	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47462	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47463	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47464	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47465	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47466	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47467	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47468	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47469	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47470	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47471	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47472	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47473	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47474	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47475	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GATTGGCCCAGGATGTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47476	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47477	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47478	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47479	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47480	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47481	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47482	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47483	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47484	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47485	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47486	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47487	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47488	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47489	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47490	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TTAGGAGGCTCGGGTCGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47491	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47492	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47493	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47494	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47495	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47496	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47497	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47498	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47499	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47500	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47501	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47502	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47503	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47504	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47505	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				TCCTCGGAGCCGGTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47506	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47507	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47508	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47509	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47510	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47511	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47512	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47513	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47514	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47515	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47516	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47517	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47518	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47519	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47520	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GGTGGAGTCCGCCCCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47521	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47522	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47523	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47524	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47525	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47526	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47527	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47528	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47529	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47530	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47531	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47532	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47533	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47534	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47535	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				CGGTTGCCGCCGCAAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79337	chr19	1251408	1271239	1251409	1271240	47536	hg19	N/A	N/A	N/A	Enhatls85128	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	307
enhrx-79338	chr19	1251408	1271239	1251409	1271240	47537	hg19	N/A	N/A	N/A	Enhatls85129	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	308
enhrx-79339	chr19	1251408	1271239	1251409	1271240	47538	hg19	N/A	N/A	N/A	Enhatls85130	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	309
enhrx-79340	chr19	1251408	1271239	1251409	1271240	47539	hg19	N/A	N/A	N/A	Enhatls85131	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	310
enhrx-79341	chr19	1251408	1271239	1251409	1271240	47540	hg19	N/A	N/A	N/A	Enhatls85132	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	311
enhrx-79342	chr19	1251408	1271239	1251409	1271240	47541	hg19	N/A	N/A	N/A	Enhatls85133	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	312
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47542	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47543	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					MIDN	chr19	1248552	1259143	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47544	hg19	N/A	enh4952	N/A	Enhatls85134	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47545	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47546	hg19	N/A	enh4952	fant55774	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47547	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47548	hg19	N/A	enh4952	fant55775	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79343	chr19	1251408	1271239	1251409	1271240	47549	hg19	N/A	enh4952	N/A	N/A	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	313
enhrx-79344	chr19	1251408	1271239	1251409	1271240	47550	hg19	N/A	N/A	N/A	Enhatls85135	enhancer	E_463				GTTCCCGGATGGAGTGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"WDR18,MED16"	direct	Highly Significant	NA					CIRBP	chr19	1259383	1274810	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	314
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47551	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGTTTCTCTGACAATCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47552	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				GGTTTCTCTGACAATCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47553	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGTTTCTCTGACAATCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47554	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				GGTTTCTCTGACAATCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47555	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TACATTGCAGCAGTGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47556	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				TACATTGCAGCAGTGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47557	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TACATTGCAGCAGTGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47558	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				TACATTGCAGCAGTGATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47559	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TGGGACACGTGGGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47560	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				TGGGACACGTGGGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47561	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TGGGACACGTGGGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47562	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				TGGGACACGTGGGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47563	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				AACTGGGAGCCTTTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47564	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				AACTGGGAGCCTTTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47565	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				AACTGGGAGCCTTTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47566	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				AACTGGGAGCCTTTCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47567	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TCCAGTCTCTTCTTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47568	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				TCCAGTCTCTTCTTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47569	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TCCAGTCTCTTCTTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47570	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				TCCAGTCTCTTCTTGTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47571	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TGTTCCTGGCAGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47572	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				TGTTCCTGGCAGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47573	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				TGTTCCTGGCAGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47574	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				TGTTCCTGGCAGGCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47575	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				CACCCGGGAGGGAAGTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47576	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				CACCCGGGAGGGAAGTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47577	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				CACCCGGGAGGGAAGTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47578	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				CACCCGGGAGGGAAGTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47579	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGGCAAGGGACAAGGGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47580	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				GGGCAAGGGACAAGGGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47581	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGGCAAGGGACAAGGGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47582	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				GGGCAAGGGACAAGGGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47583	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				CATCTGCCACCCTTGAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47584	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				CATCTGCCACCCTTGAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47585	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				CATCTGCCACCCTTGAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47586	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				CATCTGCCACCCTTGAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47587	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGGCGAGGAACATTCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47588	hg19	N/A	enh62716	fant55824	Enhatls85319	enhancer	E_464				GGGCGAGGAACATTCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47589	hg19	N/A	enh62716	N/A	Enhatls85319	enhancer	E_464				GGGCGAGGAACATTCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79526	chr19	2027837	2034863	2027838	2034864	47590	hg19	N/A	N/A	N/A	Enhatls85319	enhancer	E_464				GGGCGAGGAACATTCACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	LINGO3	direct	Highly Significant	NA					BTBD2	chr19	1985447	2034881	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	496
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47591	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47592	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47593	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47594	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47595	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47596	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47597	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47598	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47599	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				AGAGACAGGCCAGGCAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47600	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47601	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47602	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47603	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47604	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47605	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47606	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47607	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47608	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CGGCAGGTCTCCCCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47609	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47610	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47611	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47612	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47613	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47614	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47615	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47616	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47617	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTTTTAGGTCTGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47618	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47619	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47620	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47621	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47622	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47623	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47624	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47625	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47626	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGCCACCGCCAGCCTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47627	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47628	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47629	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47630	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47631	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47632	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47633	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47634	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47635	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCGGTTTATCGAGCCGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47636	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47637	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47638	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47639	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47640	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47641	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47642	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47643	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47644	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGACAGGGACTTTACCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47645	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47646	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47647	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47648	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47649	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47650	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47651	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47652	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47653	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GAGGGAGCGGGAGCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47654	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47655	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47656	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47657	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47658	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47659	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47660	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47661	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47662	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				ATTAAAACCCGTGCAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47663	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47664	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47665	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47666	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47667	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47668	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47669	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47670	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47671	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				GGTTTACAGGAAGCAGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47672	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47673	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47674	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47675	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47676	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47677	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47678	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47679	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47680	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCAGGAGAGCAAACGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47681	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47682	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47683	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47684	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47685	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47686	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47687	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47688	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47689	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				CAGCGAATTCCAGCTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47690	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47691	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47692	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47693	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47694	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47695	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47696	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47697	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47698	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TTCAAGGCCACCTTCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47699	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47700	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47701	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47702	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47703	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47704	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47705	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47706	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47707	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCTGCGAGCTATAAAGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47708	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47709	hg19	N/A	enh4959	fant55860	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47710	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47711	hg19	N/A	enh4959	fant55861	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47712	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47713	hg19	N/A	enh4959	fant55862	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47714	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47715	hg19	N/A	enh4959	fant55863	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79662	chr19	2540075	2548129	2540077	2548131	47716	hg19	N/A	enh4959	N/A	Enhatls85465	enhancer	E_465				TCCTTTTTCGAGGCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47717	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				GGCATGGAAAACCACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47718	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				GTCTGTCGCTTGTCTGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47719	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				ACCGGCGGGGCGGGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47720	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				CCGGGCAGGTCCAGACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47721	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				CTGGACTCTGGGTTACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47722	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				GCAGGACACAGAGACCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47723	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				CCCGGTCGCCCGGCTTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47724	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				AGGGCTTCAGAGGCTCGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47725	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				GCGGAGCTGCTGCCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47726	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				ATGCAAGGACAAGCTGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79663	chr19	2577927	2579643	2577929	2579645	47727	hg19	N/A	enh17850	N/A	Enhatls85466	enhancer	E_466				GGACGCACCCCCACGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47728	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				GCTACTCTGGGAGGCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47729	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				AGCCAGGCTGAGAAAATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47730	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				CCTCTGTGTACCCACCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47731	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				GTGATAAGAAGTCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47732	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				GAGATGGCAGTCTGGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47733	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				CTGGGAGCACCACGTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47734	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				TTTGTCGGATAGAGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47735	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				AGCAGCGTCCAGGAAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47736	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				GTGCTGACTTGATAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79665	chr19	2694510	2697096	2694512	2697098	47737	hg19	N/A	enh60738	N/A	Enhatls85468	enhancer	E_467				GAGAGCCTCATCATCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,LINGO3"	direct	Highly Significant	NA					GNG7	chr19	2511218	2702694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47738	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47739	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47740	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47741	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47742	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47743	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47744	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				GAACAGGGCAGTCAGGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47745	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47746	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47747	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47748	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47749	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47750	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47751	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				ACAGAACCCCAGTGCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47752	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47753	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47754	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47755	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47756	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47757	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47758	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				GCAGCTAGTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47759	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47760	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47761	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47762	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47763	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47764	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47765	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				AGCAGCTGCGTTTCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47766	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47767	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47768	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47769	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47770	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47771	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47772	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				GCCAAGCCCCAGTCATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47773	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47774	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47775	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47776	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47777	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47778	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47779	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				GGATACCCCCAAAGGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47780	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47781	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47782	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47783	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47784	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47785	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47786	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				AGCAATGGATTGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47787	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47788	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47789	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47790	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47791	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47792	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47793	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				CATCAAATCTGTGTCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47794	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47795	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47796	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47797	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47798	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47799	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47800	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				TGAGAGTTGGAAGACAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47801	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47802	hg19	N/A	enh17859	fant55907	Enhatls85566	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47803	hg19	N/A	enh17859	N/A	Enhatls85566	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47804	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47805	hg19	N/A	enh17859	N/A	Enhatls85567	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47806	hg19	N/A	enh17859	N/A	N/A	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79763	chr19	3140139	3144064	3140141	3144066	47807	hg19	N/A	enh17859	N/A	Enhatls85568	enhancer	E_468				GAGGAGGGGTGGATCACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	733
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47808	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47809	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47810	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47811	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47812	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47813	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47814	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47815	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47816	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				ACACTGAGACCCGAGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47817	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47818	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47819	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47820	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47821	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47822	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47823	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47824	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47825	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				CAGGGTAAGCAGCCGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47826	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47827	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47828	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47829	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47830	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47831	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47832	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47833	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47834	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				AGGAGTGGGTCTCAGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47835	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47836	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47837	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47838	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47839	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47840	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47841	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47842	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47843	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				CTTTGGACGGGCCCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47844	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47845	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47846	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47847	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47848	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47849	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47850	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47851	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47852	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				ATCTGTGCGTCATTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47853	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47854	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47855	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47856	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47857	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47858	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47859	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47860	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47861	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				CAGGGTTCAGGCTTTTGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47862	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47863	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47864	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47865	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47866	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47867	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47868	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47869	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47870	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GTGGCCACTGGACATGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47871	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47872	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47873	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47874	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47875	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47876	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47877	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47878	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47879	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GGGTCGCCCAGCCAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47880	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47881	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47882	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47883	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47884	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47885	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47886	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47887	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47888	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				CCTGCTCCCCTCTAATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47889	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47890	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47891	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47892	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47893	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47894	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47895	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47896	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47897	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				CGGTGCCGCCTGCCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47898	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47899	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47900	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47901	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47902	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47903	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47904	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47905	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47906	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				ACTCCCTTGCGTGTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47907	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47908	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47909	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47910	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47911	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47912	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47913	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47914	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47915	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GCAAGGGCAGGAGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47916	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47917	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47918	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47919	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47920	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47921	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47922	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47923	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47924	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GAAGGAGCAAAACGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47925	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47926	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47927	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47928	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47929	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47930	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47931	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47932	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47933	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GGGTGTGCGTCACCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47934	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47935	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47936	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47937	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47938	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47939	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47940	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47941	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47942	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				GGTCTGTTACCCCTTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47943	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47944	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47945	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47946	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47947	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47948	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47949	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47950	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47951	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				TTTCTCTCGTCCGCAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47952	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47953	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47954	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47955	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47956	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47957	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47958	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47959	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47960	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				AGCATCCCCCCATCCCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79764	chr19	3148900	3165978	3148902	3165980	47961	hg19	N/A	N/A	N/A	Enhatls85569	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	734
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47962	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47963	hg19	N/A	N/A	fant55908	Enhatls85570	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47964	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47965	hg19	N/A	N/A	fant55909	Enhatls85570	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79765	chr19	3148900	3165978	3148902	3165980	47966	hg19	N/A	N/A	N/A	Enhatls85570	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	735
enhrx-79766	chr19	3148900	3165978	3148902	3165980	47967	hg19	N/A	N/A	N/A	Enhatls85571	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	736
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47968	hg19	N/A	N/A	N/A	Enhatls85572	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	24				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3148900	3165978	3148902	3165980	47969	hg19	N/A	N/A	fant55910	Enhatls85572	enhancer	E_469				ATCTTTAATTTCAGCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					GNA15	chr19	3136032	3163749	2070				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47970	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				GAGAGCTCAGTCCAGGGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47971	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				GCAGGCTCAGTACAGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47972	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				AGTGTTCAGTGCAGAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47973	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				TCAGGGCTTAGTCCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47974	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				GTAGGTGCCTGAGTCATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47975	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				CACCAAGCAGAAAGGGGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47976	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				ACTGAACCGTAAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3170302	3173046	3170304	3173048	47977	hg19	N/A	enh17860	N/A	Enhatls85572	enhancer	E_470				GTATCGGCCCTGAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	5077				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47978	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				CCTGCCCTGAGGTTTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47979	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				CCTGCCCTGAGGTTTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47980	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				CCTGCCCTGAGGTTTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47981	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				AGGGGAGACACACCCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47982	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				AGGGGAGACACACCCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47983	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				AGGGGAGACACACCCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47984	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GGAGGCATGACCTTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47985	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				GGAGGCATGACCTTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47986	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GGAGGCATGACCTTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47987	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GTGGGAGACACACCCTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47988	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				GTGGGAGACACACCCTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47989	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GTGGGAGACACACCCTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47990	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				CTATGCACCTCAATCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47991	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				CTATGCACCTCAATCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47992	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				CTATGCACCTCAATCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47993	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GACAAGCTGGTAGGGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47994	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				GACAAGCTGGTAGGGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47995	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GACAAGCTGGTAGGGTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47996	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GGACCTGTGTGTCCTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1445				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47997	hg19	N/A	enh17860	fant55911	N/A	enhancer	E_471				GGACCTGTGTGTCCTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	1401				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79767	chr19	3175823	3177697	3175825	3177699	47998	hg19	N/A	enh17860	N/A	N/A	enhancer	E_471				GGACCTGTGTGTCCTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"GNA11,MAP2K2,LINGO3"	direct	Highly Significant	NA					S1PR4	chr19	3178768	3180332	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	737
enhrx-79792	chr19	3342913	3344340	3342915	3344342	47999	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				CTGCAGAAATCTAGCAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48000	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				CTGCAGAAATCTAGCAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48001	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				ACACACATGCCGATCTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48002	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				ACACACATGCCGATCTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48003	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				TGCTAGCATGCAGTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48004	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				TGCTAGCATGCAGTAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48005	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				GTAACCGCGATGCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48006	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				GTAACCGCGATGCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48007	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				GAGAGGGGCAGGTCTAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48008	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				GAGAGGGGCAGGTCTAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48009	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				CTCCGGGCACAGCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48010	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				CTCCGGGCACAGCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48011	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				GCAAGCCTGAGCAGTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48012	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				GCAAGCCTGAGCAGTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48013	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				CTGGGCACCGGGACAACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48014	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				CTGGGCACCGGGACAACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48015	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				CTGTGTGGCCTATCAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48016	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				CTGTGTGGCCTATCAGAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48017	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				GGGCTTGAGGTGGGTCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48018	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				GGGCTTGAGGTGGGTCCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48019	hg19	N/A	enh17861	N/A	Enhatls85597	enhancer	E_472				TGGGAGAGCAACCTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79792	chr19	3342913	3344340	3342915	3344342	48020	hg19	N/A	enh17861	fant55919	Enhatls85597	enhancer	E_472				TGGGAGAGCAACCTTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	762
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48021	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48022	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48023	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48024	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48025	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48026	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48027	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48028	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48029	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48030	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48031	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48032	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48033	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48034	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCTCGGGGTGCCAGCCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48035	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48036	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48037	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48038	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48039	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48040	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48041	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48042	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48043	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48044	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48045	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48046	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48047	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48048	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGAAGCCGGTGGGGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48049	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48050	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48051	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48052	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48053	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48054	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48055	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48056	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48057	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48058	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48059	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48060	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48061	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48062	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCGGCGCCTACAGCGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48063	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48064	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48065	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48066	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48067	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48068	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48069	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48070	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48071	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48072	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48073	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48074	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48075	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48076	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGCCTCCTCGACTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48077	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48078	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48079	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48080	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48081	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48082	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48083	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48084	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48085	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48086	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48087	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48088	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48089	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48090	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCCGCAGCGAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48091	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48092	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48093	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48094	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48095	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48096	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48097	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48098	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48099	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48100	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48101	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48102	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48103	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48104	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCTCAGGCTGCTCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48105	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48106	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48107	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48108	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48109	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48110	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48111	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48112	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48113	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48114	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48115	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48116	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48117	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48118	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GGGAGGGAGCGAGCGCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48119	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48120	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48121	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48122	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48123	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48124	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48125	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48126	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48127	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48128	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48129	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48130	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48131	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48132	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTCGGTCCCCGGCGAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48133	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48134	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48135	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48136	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48137	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48138	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48139	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48140	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48141	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48142	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48143	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48144	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48145	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48146	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCCGGGCGAAAACGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48147	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48148	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48149	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48150	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48151	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48152	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48153	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48154	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48155	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48156	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48157	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48158	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48159	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48160	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AAGGGTTCTCCCCTATAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48161	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48162	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48163	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48164	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48165	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48166	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48167	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48168	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48169	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48170	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48171	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48172	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48173	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48174	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGTGAACCGGGGGAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48175	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48176	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48177	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48178	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48179	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48180	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48181	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48182	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48183	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48184	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48185	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48186	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48187	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48188	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATGTGGGCTCCAGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48189	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48190	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48191	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48192	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48193	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48194	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48195	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48196	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48197	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48198	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48199	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48200	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48201	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48202	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				ATTATTGGATACCCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48203	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48204	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48205	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48206	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48207	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48208	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48209	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48210	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48211	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48212	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48213	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48214	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48215	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48216	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCTGGAGAGACACACAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48217	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48218	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48219	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48220	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48221	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48222	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48223	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48224	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48225	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48226	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48227	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48228	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48229	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48230	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CTGCGGGTCCCCAGCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48231	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48232	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48233	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48234	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48235	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48236	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48237	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48238	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48239	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48240	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48241	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48242	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48243	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48244	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GACCAGCTCACCGTGCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48245	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48246	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48247	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48248	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48249	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48250	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48251	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48252	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48253	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48254	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48255	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48256	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48257	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48258	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGAAGAAGTGACGTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48259	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48260	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48261	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48262	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48263	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48264	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48265	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48266	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48267	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48268	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48269	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48270	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48271	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48272	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCAGCTCGGGGGTGATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48273	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48274	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48275	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48276	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48277	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48278	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48279	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48280	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48281	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48282	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48283	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48284	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48285	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48286	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TCAAGCGGAGAGGGGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48287	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48288	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48289	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48290	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48291	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48292	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48293	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48294	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48295	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48296	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48297	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48298	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48299	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48300	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GTAAATACGGGAGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48301	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48302	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48303	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48304	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48305	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48306	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48307	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48308	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48309	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48310	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48311	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48312	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48313	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48314	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CCCAACTTTCAAAGAAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48315	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48316	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48317	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48318	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48319	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48320	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48321	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48322	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48323	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48324	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48325	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48326	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48327	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48328	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GAGGCGGGCGGCGCGAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48329	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48330	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48331	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48332	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48333	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48334	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48335	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48336	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48337	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48338	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48339	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48340	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48341	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48342	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				AGGCGGCGAGGAGAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48343	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48344	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48345	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48346	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48347	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48348	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48349	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48350	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48351	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48352	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48353	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48354	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48355	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48356	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				GCCGGGCGAGGACCGTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48357	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48358	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48359	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48360	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48361	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48362	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48363	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48364	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48365	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48366	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48367	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48368	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48369	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48370	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				TGCTTCAAAACTCCGGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79793	chr19	3358794	3372512	3358796	3372514	48371	hg19	N/A	N/A	fant55921	N/A	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	763
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48372	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48373	hg19	N/A	N/A	fant55922	Enhatls85598	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79794	chr19	3358794	3372512	3358796	3372514	48374	hg19	N/A	N/A	N/A	Enhatls85598	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	764
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48375	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48376	hg19	N/A	enh17862	N/A	Enhatls85599	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48377	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48378	hg19	N/A	enh17862	fant55923	N/A	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48379	hg19	N/A	enh17862	N/A	N/A	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48380	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48381	hg19	N/A	enh17862	fant55924	Enhatls85600	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48382	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48383	hg19	N/A	enh17862	fant55925	Enhatls85600	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3358794	3372512	3358796	3372514	48384	hg19	N/A	enh17862	N/A	Enhatls85600	enhancer	E_473				CGGGATGCCCCCCGCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48385	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48386	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48387	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48388	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48389	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48390	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48391	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48392	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48393	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTCATCTAGTGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48394	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48395	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48396	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48397	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48398	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48399	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48400	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48401	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48402	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGCGTGTCTGGGGTGCATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48403	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48404	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48405	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48406	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48407	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48408	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48409	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48410	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48411	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ATCATTCCAACCTCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48412	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48413	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48414	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48415	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48416	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48417	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48418	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48419	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48420	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGTGGGTCCTGGGATCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48421	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48422	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48423	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48424	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48425	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48426	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48427	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48428	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48429	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GCAGGATCCGGAACGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48430	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48431	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48432	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48433	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48434	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48435	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48436	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48437	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48438	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TGAACCTGCGGCCTGCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48439	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48440	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48441	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48442	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48443	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48444	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48445	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48446	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48447	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				TCACACCTCCCTGATTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48448	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48449	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48450	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48451	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48452	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48453	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48454	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48455	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48456	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGGCTGGGAGGAGACTCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48457	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48458	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48459	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48460	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48461	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48462	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48463	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48464	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48465	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				GGTCACCCTGGGACATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48466	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48467	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48468	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48469	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48470	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48471	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48472	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48473	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48474	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				AGAAAGAATGTGAGCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48475	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48476	hg19	N/A	enh17863	fant55927	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48477	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48478	hg19	N/A	enh17863	fant55928	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48479	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48480	hg19	N/A	enh17863	fant55929	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48481	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48482	hg19	N/A	enh17863	fant55930	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79795	chr19	3395525	3405531	3395527	3405533	48483	hg19	N/A	enh17863	N/A	Enhatls85601	enhancer	E_474				ACCACTCATGTGTCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	765
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48484	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				TGGGGCTGGCTGGGTTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48485	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				TGGGGCTGGCTGGGTTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48486	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				TGGGGCTGGCTGGGTTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48487	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				TGGGGCTGGCTGGGTTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48488	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				TGGGGCTGGCTGGGTTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48489	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				CTAGCCCTGACAGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48490	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				CTAGCCCTGACAGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48491	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				CTAGCCCTGACAGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48492	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				CTAGCCCTGACAGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48493	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				CTAGCCCTGACAGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48494	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				TATGCTTTGTGACCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48495	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				TATGCTTTGTGACCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48496	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				TATGCTTTGTGACCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48497	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				TATGCTTTGTGACCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48498	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				TATGCTTTGTGACCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48499	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				CATGGTGGAGACCAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48500	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				CATGGTGGAGACCAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48501	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				CATGGTGGAGACCAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48502	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				CATGGTGGAGACCAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48503	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				CATGGTGGAGACCAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48504	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				GGATGGGACACCCGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48505	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				GGATGGGACACCCGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48506	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				GGATGGGACACCCGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48507	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				GGATGGGACACCCGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48508	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				GGATGGGACACCCGGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48509	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				TCCGGTCCTTAAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48510	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				TCCGGTCCTTAAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48511	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				TCCGGTCCTTAAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48512	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				TCCGGTCCTTAAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48513	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				TCCGGTCCTTAAGTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48514	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				CGCTTGCTCCTTATGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48515	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				CGCTTGCTCCTTATGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48516	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				CGCTTGCTCCTTATGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48517	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				CGCTTGCTCCTTATGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48518	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				CGCTTGCTCCTTATGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48519	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				GAGTAGCAGCCGCAACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48520	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				GAGTAGCAGCCGCAACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48521	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				GAGTAGCAGCCGCAACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48522	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				GAGTAGCAGCCGCAACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48523	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				GAGTAGCAGCCGCAACTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48524	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				CCACGGTGACTCAGACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48525	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				CCACGGTGACTCAGACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48526	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				CCACGGTGACTCAGACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48527	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				CCACGGTGACTCAGACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48528	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				CCACGGTGACTCAGACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48529	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				GGACGACTACAATTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48530	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				GGACGACTACAATTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48531	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				GGACGACTACAATTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48532	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				GGACGACTACAATTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48533	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				GGACGACTACAATTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48534	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				GGATCTCTTTGGTTCCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48535	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				GGATCTCTTTGGTTCCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48536	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				GGATCTCTTTGGTTCCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48537	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				GGATCTCTTTGGTTCCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48538	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				GGATCTCTTTGGTTCCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48539	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				GATGTGGCATTCACGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48540	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				GATGTGGCATTCACGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48541	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				GATGTGGCATTCACGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48542	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				GATGTGGCATTCACGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48543	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				GATGTGGCATTCACGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48544	hg19	N/A	enh17864	N/A	Enhatls85602	enhancer	E_475				AACAGGGTCCCTACAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79796	chr19	3432275	3436039	3432277	3436041	48545	hg19	N/A	N/A	N/A	Enhatls85602	enhancer	E_475				AACAGGGTCCCTACAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	766
enhrx-79797	chr19	3432275	3436039	3432277	3436041	48546	hg19	N/A	N/A	N/A	Enhatls85603	enhancer	E_475				AACAGGGTCCCTACAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-79798	chr19	3432275	3436039	3432277	3436041	48547	hg19	N/A	N/A	N/A	Enhatls85604	enhancer	E_475				AACAGGGTCCCTACAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-79799	chr19	3432275	3436039	3432277	3436041	48548	hg19	N/A	N/A	N/A	Enhatls85605	enhancer	E_475				AACAGGGTCCCTACAGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					NFIC	chr19	3314402	3469217	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48549	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGTCGATCTTCCACATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48550	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGTCGATCTTCCACATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48551	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGTCGATCTTCCACATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48552	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGTCGATCTTCCACATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48553	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGTCGATCTTCCACATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48554	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGGATTTCCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48555	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGGATTTCCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48556	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGGATTTCCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48557	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GTGTGGATTTCCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48558	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GTGTGGATTTCCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48559	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGGGCATGGGCGAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48560	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGGGCATGGGCGAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48561	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGGGCATGGGCGAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48562	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCGGGCATGGGCGAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48563	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCGGGCATGGGCGAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48564	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				CGGCGGTTCCCAGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48565	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				CGGCGGTTCCCAGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48566	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				CGGCGGTTCCCAGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48567	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				CGGCGGTTCCCAGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48568	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				CGGCGGTTCCCAGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48569	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCTGGTTCTGCCCATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48570	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCTGGTTCTGCCCATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48571	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCTGGTTCTGCCCATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48572	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCTGGTTCTGCCCATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48573	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCTGGTTCTGCCCATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48574	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGACCCCACCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48575	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGACCCCACCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48576	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GTGTGACCCCACCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48577	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GTGTGACCCCACCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48578	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GTGTGACCCCACCCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48579	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGTCTCTGCGGCCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48580	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGTCTCTGCGGCCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48581	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GGCGTCTCTGCGGCCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48582	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCGTCTCTGCGGCCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48583	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GGCGTCTCTGCGGCCTTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48584	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCGCCGGCCACAATCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48585	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCGCCGGCCACAATCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48586	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCGCCGGCCACAATCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48587	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCGCCGGCCACAATCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48588	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCGCCGGCCACAATCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48589	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ACGGCCCTGTTCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48590	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ACGGCCCTGTTCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48591	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ACGGCCCTGTTCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48592	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				ACGGCCCTGTTCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48593	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				ACGGCCCTGTTCCAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48594	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCTGGGCTGAGTTCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48595	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCTGGGCTGAGTTCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48596	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCTGGGCTGAGTTCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48597	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCTGGGCTGAGTTCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48598	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCTGGGCTGAGTTCACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48599	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCCAGGGCTCGTGTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48600	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCCAGGGCTCGTGTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48601	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				GCCAGGGCTCGTGTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48602	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCCAGGGCTCGTGTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48603	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				GCCAGGGCTCGTGTAGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48604	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGTGTACGTCAGGCTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48605	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGTGTACGTCAGGCTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48606	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGTGTACGTCAGGCTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48607	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				AGTGTACGTCAGGCTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48608	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				AGTGTACGTCAGGCTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48609	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGGGTCGCCCCAGGAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48610	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGGGTCGCCCCAGGAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48611	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				AGGGTCGCCCCAGGAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48612	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				AGGGTCGCCCCAGGAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48613	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				AGGGTCGCCCCAGGAAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48614	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ATGTAGCTGGTGCAGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48615	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ATGTAGCTGGTGCAGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48616	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				ATGTAGCTGGTGCAGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48617	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				ATGTAGCTGGTGCAGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48618	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				ATGTAGCTGGTGCAGTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48619	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				TCTGCGATGAGAGGTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					FZR1	chr19	3506310	3538334	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48620	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				TCTGCGATGAGAGGTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48621	hg19	N/A	enh109821	N/A	N/A	enhancer	E_476				TCTGCGATGAGAGGTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48622	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				TCTGCGATGAGAGGTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TEKTIP1	chr19	3539170	3544030	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79821	chr19	3535036	3539990	3535038	3539992	48623	hg19	N/A	enh109821	N/A	Enhatls85628	enhancer	E_476				TCTGCGATGAGAGGTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	791
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48624	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48625	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48626	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48627	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48628	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48629	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48630	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48631	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48632	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48633	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48634	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48635	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48636	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48637	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48638	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48639	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48640	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48641	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48642	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48643	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48644	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48645	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GAGTGCAATGGCGCGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48646	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48647	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48648	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48649	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48650	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48651	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48652	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48653	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48654	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48655	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48656	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48657	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48658	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48659	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48660	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48661	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48662	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48663	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48664	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48665	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48666	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48667	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GATGGGGAGGGAGGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48668	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48669	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48670	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48671	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48672	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48673	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48674	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48675	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48676	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48677	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48678	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48679	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48680	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48681	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48682	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48683	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48684	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48685	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48686	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48687	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48688	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48689	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				AGACGGGGGTTTCTCCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48690	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48691	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48692	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48693	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48694	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48695	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48696	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48697	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48698	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48699	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48700	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48701	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48702	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48703	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48704	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48705	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48706	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48707	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48708	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48709	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48710	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48711	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CCTCATGATCTGCCCGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48712	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48713	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48714	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48715	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48716	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48717	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48718	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48719	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48720	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48721	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48722	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48723	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48724	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48725	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48726	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48727	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48728	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48729	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48730	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48731	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48732	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48733	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CAAAGACTGACTGAAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48734	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48735	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48736	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48737	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48738	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48739	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48740	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48741	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48742	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48743	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48744	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48745	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48746	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48747	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48748	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48749	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48750	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48751	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48752	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48753	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48754	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48755	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGCGTGACTCAGTCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48756	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48757	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48758	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48759	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48760	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48761	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48762	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48763	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48764	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48765	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48766	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48767	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48768	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48769	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48770	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48771	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48772	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48773	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48774	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48775	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48776	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48777	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TCTGGTCTACCATTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48778	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48779	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48780	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48781	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48782	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48783	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48784	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48785	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48786	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48787	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48788	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48789	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48790	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48791	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48792	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48793	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48794	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48795	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48796	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48797	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48798	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48799	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CTTGCGCTGAGAGCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48800	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48801	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48802	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48803	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48804	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48805	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48806	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48807	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48808	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48809	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48810	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48811	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48812	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48813	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48814	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48815	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48816	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48817	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48818	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48819	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48820	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48821	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GGAGGAGCTGTAACGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48822	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48823	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48824	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48825	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48826	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48827	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48828	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48829	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48830	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48831	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48832	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48833	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48834	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48835	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48836	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48837	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48838	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48839	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48840	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48841	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48842	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48843	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGTTGTGTTGTGTTTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48844	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48845	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48846	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48847	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48848	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48849	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48850	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48851	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48852	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48853	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48854	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48855	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48856	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48857	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48858	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48859	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48860	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48861	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48862	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48863	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48864	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48865	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GCAGTGAGCTGAGATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48866	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48867	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48868	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48869	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48870	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48871	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48872	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48873	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48874	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48875	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48876	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48877	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48878	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48879	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48880	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48881	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48882	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48883	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48884	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48885	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48886	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48887	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				ACATAGGAAACTTCTCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48888	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48889	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48890	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48891	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48892	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48893	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48894	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48895	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48896	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48897	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48898	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48899	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48900	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48901	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48902	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48903	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48904	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48905	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48906	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48907	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48908	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48909	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GCTAGGGTTAAGGTCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48910	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48911	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48912	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48913	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48914	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48915	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48916	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48917	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48918	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48919	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48920	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48921	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48922	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48923	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48924	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48925	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48926	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48927	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48928	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48929	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48930	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48931	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CCGGTCGCCCCATCCGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48932	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48933	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48934	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48935	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48936	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48937	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48938	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48939	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48940	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48941	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48942	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48943	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48944	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48945	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48946	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48947	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48948	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48949	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48950	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48951	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48952	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48953	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				CGAGTGGCGGACTTGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48954	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48955	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48956	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48957	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48958	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48959	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48960	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48961	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48962	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48963	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48964	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48965	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48966	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48967	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48968	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48969	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48970	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48971	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48972	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48973	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48974	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48975	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				GGGAGGTTGCTGAGTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48976	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48977	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48978	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48979	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48980	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48981	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48982	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48983	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48984	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48985	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48986	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48987	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48988	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48989	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48990	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48991	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48992	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	48993	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48994	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	48995	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48996	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	48997	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				AGGCCTTCATTAGCATGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48998	hg19	N/A	N/A	N/A	Enhatls85639	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	48999	hg19	N/A	enh4966	N/A	Enhatls85639	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49000	hg19	N/A	enh4966	N/A	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49001	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49002	hg19	N/A	enh4966	fant55941	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49003	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49004	hg19	N/A	enh4966	fant55942	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49005	hg19	N/A	enh4966	N/A	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79832	chr19	3550710	3573745	3550712	3573747	49006	hg19	N/A	N/A	N/A	Enhatls85640	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	802
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49007	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49008	hg19	N/A	enh17866	fant55943	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49009	hg19	N/A	enh17866	N/A	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49010	hg19	N/A	enh17866	N/A	Enhatls85641	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49011	hg19	N/A	N/A	N/A	Enhatls85641	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49012	hg19	N/A	enh110934	N/A	Enhatls85641	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49013	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49014	hg19	N/A	enh110934	fant55944	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79833	chr19	3550710	3573745	3550712	3573747	49015	hg19	N/A	enh110934	N/A	N/A	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	803
enhrx-79834	chr19	3550710	3573745	3550712	3573747	49016	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79834	chr19	3550710	3573745	3550712	3573747	49017	hg19	N/A	N/A	N/A	Enhatls85642	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	804
enhrx-79835	chr19	3550710	3573745	3550712	3573747	49018	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MFSD12	chr19	3538260	3573629	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79835	chr19	3550710	3573745	3550712	3573747	49019	hg19	N/A	N/A	N/A	Enhatls85643	enhancer	E_477				TGGAGCGTCGCGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					HMG20B	chr19	3572776	3579083	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49020	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				TTTGCGACACACCCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49021	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				TTTGCGACACACCCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49022	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				TGGCTGGATCCCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49023	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				TGGCTGGATCCCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49024	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				AGGGGAAGGACGGGCTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49025	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				AGGGGAAGGACGGGCTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49026	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				TGGCGGCACAGGACGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49027	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				TGGCGGCACAGGACGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49028	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				GGACGGAGAGAGCGAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49029	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				GGACGGAGAGAGCGAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49030	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				AGGGTGTCCCGGCGTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49031	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				AGGGTGTCCCGGCGTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49032	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CGGTGGCCTGGGGGTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49033	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CGGTGGCCTGGGGGTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49034	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				GAATAATGCGGGCCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49035	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				GAATAATGCGGGCCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49036	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CCAGGCGGATCGGCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49037	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CCAGGCGGATCGGCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49038	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				TCACTGGGTGCGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49039	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				TCACTGGGTGCGCTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49040	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				ATATTTGAGGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49041	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				ATATTTGAGGCCCCTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49042	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				GGTGATGGCATCGCATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49043	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				GGTGATGGCATCGCATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49044	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				AGGAACAGTCTGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49045	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				AGGAACAGTCTGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49046	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CCACCCCCCAGCTCGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49047	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CCACCCCCCAGCTCGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49048	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CGGGTGTACAAACAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49049	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CGGGTGTACAAACAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49050	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CTAGCAGCCCTCCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49051	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CTAGCAGCCCTCCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49052	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				GATAGTGGGCGGGGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49053	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				GATAGTGGGCGGGGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49054	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				GACTTAATGGGATAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49055	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				GACTTAATGGGATAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49056	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				AGTTGGATAGCCTCCTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49057	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				AGTTGGATAGCCTCCTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49058	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				TGTATAAGCTGAACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49059	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				TGTATAAGCTGAACACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49060	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				CCTAGGGCATCCTGAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49061	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				CCTAGGGCATCCTGAAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49062	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				ACAGGCTGTTCCAGCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49063	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				ACAGGCTGTTCCAGCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79850	chr19	3606282	3610626	3606284	3610628	49064	hg19	N/A	N/A	fant55947	N/A	enhancer	E_478				AATAGGAGCTCCCCAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	876				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	820
enhrx-79851	chr19	3606282	3610626	3606284	3610628	49065	hg19	N/A	N/A	fant55948	N/A	enhancer	E_478				AATAGGAGCTCCCCAGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					TBXA2R	chr19	3594506	3606875	1506				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	821
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49066	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GGCGCTCCTGAGGTAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49067	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GCCATGGGCGGCGAAACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49068	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GAGCGTGTGTCCCGACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49069	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GCGAGGAAGGCCCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49070	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				TCCCACTGGAGTCAATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49071	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GAGGCGTGGGGACCCGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49072	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GCAAACTAGGAACCTTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49073	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				GAAGTAGCGCTTCATTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49074	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				AGCGAGGTCCCCGAAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79858	chr19	3625746	3627262	3625748	3627264	49075	hg19	N/A	N/A	N/A	Enhatls85664	enhancer	E_479				CATAGGTGTTCATTGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					CACTIN	chr19	3610644	3626815	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	828
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49076	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GTGACCACATGAGAATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49077	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				GTGACCACATGAGAATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49078	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GTGACCACATGAGAATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49079	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				GTGACCACATGAGAATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49080	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				GTGACCACATGAGAATGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49081	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ATCCAGGCAGAGCTCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49082	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				ATCCAGGCAGAGCTCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49083	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ATCCAGGCAGAGCTCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49084	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				ATCCAGGCAGAGCTCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49085	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				ATCCAGGCAGAGCTCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49086	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				TCTCTGTGATGCTTAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49087	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				TCTCTGTGATGCTTAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49088	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				TCTCTGTGATGCTTAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49089	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				TCTCTGTGATGCTTAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49090	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				TCTCTGTGATGCTTAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49091	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				TGGGCGAGTACCGGAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49092	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				TGGGCGAGTACCGGAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49093	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				TGGGCGAGTACCGGAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49094	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				TGGGCGAGTACCGGAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49095	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				TGGGCGAGTACCGGAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49096	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ACTCCTACTCCCCCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49097	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				ACTCCTACTCCCCCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49098	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ACTCCTACTCCCCCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49099	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				ACTCCTACTCCCCCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49100	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				ACTCCTACTCCCCCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49101	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				AGGCGTGAGGCAGCTCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49102	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				AGGCGTGAGGCAGCTCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49103	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				AGGCGTGAGGCAGCTCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49104	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				AGGCGTGAGGCAGCTCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49105	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				AGGCGTGAGGCAGCTCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49106	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CCAACACCCCCTATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49107	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				CCAACACCCCCTATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49108	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CCAACACCCCCTATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49109	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				CCAACACCCCCTATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49110	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				CCAACACCCCCTATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49111	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GGGACGGCCCCCAAGGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49112	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				GGGACGGCCCCCAAGGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49113	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GGGACGGCCCCCAAGGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49114	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				GGGACGGCCCCCAAGGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49115	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				GGGACGGCCCCCAAGGCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49116	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GTGCTGGTGAAGCCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49117	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				GTGCTGGTGAAGCCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49118	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				GTGCTGGTGAAGCCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49119	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				GTGCTGGTGAAGCCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49120	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				GTGCTGGTGAAGCCTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49121	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ATGCCTCTCACCACGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49122	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				ATGCCTCTCACCACGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49123	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				ATGCCTCTCACCACGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49124	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				ATGCCTCTCACCACGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49125	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				ATGCCTCTCACCACGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49126	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CGGGAGAAGGGGGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49127	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				CGGGAGAAGGGGGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49128	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CGGGAGAAGGGGGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49129	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				CGGGAGAAGGGGGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49130	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				CGGGAGAAGGGGGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49131	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CACGCACCATGTAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49132	hg19	N/A	enh44619	fant55950	Enhatls85677	enhancer	E_480				CACGCACCATGTAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49133	hg19	N/A	enh44619	N/A	Enhatls85677	enhancer	E_480				CACGCACCATGTAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49134	hg19	N/A	enh44619	N/A	N/A	enhancer	E_480				CACGCACCATGTAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79870	chr19	3655147	3657155	3655149	3657157	49135	hg19	N/A	enh44619	N/A	Enhatls85678	enhancer	E_480				CACGCACCATGTAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	840
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49136	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				CGACTCGGCGTGGGCGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49137	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				CGACTCGGCGTGGGCGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49138	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GACGGGGCTGAAGCCGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49139	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GACGGGGCTGAAGCCGCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49140	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GGGCTGCACGGTCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49141	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GGGCTGCACGGTCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49142	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GGTAACGGCCCGGCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49143	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GGTAACGGCCCGGCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49144	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GCTGGAGGTACCGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49145	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GCTGGAGGTACCGGACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49146	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GCGCGCCCTCCCTTGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49147	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GCGCGCCCTCCCTTGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49148	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				CCTGCGTGCGTGCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49149	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				CCTGCGTGCGTGCGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49150	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				ATCTTACTGACCTAATACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49151	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				ATCTTACTGACCTAATACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49152	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				TACAGCACGTGCCAATAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49153	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				TACAGCACGTGCCAATAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49154	hg19	N/A	enh99536	N/A	Enhatls85682	enhancer	E_481				GCTGTGCAGGTCCCTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79872	chr19	3697799	3700681	3697801	3700683	49155	hg19	N/A	N/A	N/A	Enhatls85682	enhancer	E_481				GCTGTGCAGGTCCCTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					PIP5K1C	chr19	3630182	3700468	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	842
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49156	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49157	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49158	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49159	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49160	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49161	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49162	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49163	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TAACAGACCTGGTTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49164	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49165	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49166	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49167	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49168	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49169	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49170	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49171	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GAAGGTGATCAGTAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49172	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49173	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49174	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49175	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49176	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49177	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49178	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49179	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CCAGATCTGGCACAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49180	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49181	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49182	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49183	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49184	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49185	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49186	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49187	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGGCCTCCCAGGCTCATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49188	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49189	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49190	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49191	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49192	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49193	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49194	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49195	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGCCTGGGTAATTATAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49196	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49197	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49198	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49199	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49200	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49201	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49202	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49203	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CGGGCTCCCAGGCTTTTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49204	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49205	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49206	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49207	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49208	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49209	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49210	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49211	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGGTGGGTCTAAATTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49212	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49213	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49214	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49215	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49216	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49217	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49218	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49219	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TGGCTATCCCACCCGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49220	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49221	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49222	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49223	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49224	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49225	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49226	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49227	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GTGGGTTCGTCTCTGAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49228	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49229	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49230	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49231	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49232	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49233	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49234	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49235	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GTACCCCAACCTCACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49236	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49237	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49238	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49239	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49240	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49241	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49242	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49243	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ACTCCTGGGCGCCGGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49244	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49245	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49246	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49247	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49248	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49249	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49250	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49251	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				TCCCCCAGCCACGCCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49252	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49253	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49254	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49255	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49256	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49257	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49258	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49259	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ATTCGGTCTCAGGAGTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49260	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49261	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49262	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49263	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49264	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49265	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49266	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49267	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGACTTGGTCCCTAAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49268	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49269	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49270	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49271	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49272	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49273	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49274	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49275	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGTGATCTCTCAAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49276	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49277	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49278	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49279	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49280	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49281	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49282	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49283	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				CAGGCCTTGCCGGAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49284	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49285	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49286	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49287	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49288	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49289	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49290	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49291	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				AGCAGACGCTTCATAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49292	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49293	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49294	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49295	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49296	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49297	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49298	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49299	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GAAACTCAGAAGCCGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49300	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49301	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49302	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49303	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49304	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49305	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49306	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49307	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				GGACAGGGTTGAGCTGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49308	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49309	hg19	N/A	enh102594	fant55967	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49310	hg19	N/A	enh102594	N/A	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49311	hg19	N/A	enh102594	fant55968	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49312	hg19	N/A	N/A	fant55968	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49313	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49314	hg19	N/A	N/A	fant55969	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79958	chr19	4050371	4055085	4050373	4055087	49315	hg19	N/A	N/A	N/A	Enhatls85783	enhancer	E_483				ATCCCGGTGGGTGACAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	928
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49316	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49317	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49318	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49319	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49320	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49321	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49322	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49323	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49324	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49325	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49326	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49327	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				ATGGTGGGGCCTCGGGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49328	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49329	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49330	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49331	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49332	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49333	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49334	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49335	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49336	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49337	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49338	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49339	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GTCGGCTCTTAGGTCCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49340	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49341	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49342	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49343	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49344	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49345	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49346	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49347	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49348	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49349	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49350	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49351	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GAGCCCCCCTGAAAAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49352	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49353	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49354	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49355	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49356	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49357	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49358	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49359	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49360	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49361	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49362	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49363	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GGGTGTGCCCCGTCCGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49364	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49365	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49366	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49367	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49368	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49369	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49370	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49371	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49372	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49373	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49374	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49375	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				CAGGGCTGAGCCCTATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49376	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49377	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49378	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49379	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49380	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49381	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49382	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49383	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49384	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49385	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49386	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49387	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				AGACCGGGCTACAGCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	indirect	Non Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49388	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49389	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49390	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49391	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49392	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49393	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49394	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49395	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49396	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49397	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49398	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49399	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GAGCTGTTCAGCCCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49400	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49401	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49402	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49403	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49404	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49405	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49406	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49407	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49408	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49409	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49410	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49411	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				TTTCGGGCAGCGCCGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49412	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49413	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49414	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49415	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49416	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49417	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49418	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49419	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49420	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49421	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49422	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49423	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GTGGATGAGTCACAGCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49424	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49425	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49426	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49427	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49428	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49429	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49430	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49431	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49432	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49433	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49434	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49435	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GAGCTGTGCTGGGTGACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49436	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49437	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49438	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49439	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49440	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49441	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49442	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49443	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49444	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49445	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49446	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49447	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				GGCCCGGAGGAGGCCATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49448	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49449	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49450	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49451	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49452	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49453	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49454	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49455	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49456	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49457	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49458	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49459	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				AGGCAGGCTCTGACGCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49460	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49461	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49462	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49463	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49464	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49465	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49466	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49467	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49468	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49469	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49470	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49471	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				TGAGCTGCCAGGCGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49472	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49473	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49474	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49475	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49476	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49477	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49478	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49479	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49480	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49481	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49482	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49483	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				ACAGGCCTTAGAGTAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49484	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49485	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49486	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49487	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49488	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49489	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49490	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49491	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49492	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49493	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49494	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49495	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				CAGGGGGTGGACACCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49496	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49497	hg19	N/A	enh4967	fant55970	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49498	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49499	hg19	N/A	enh4967	fant55971	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49500	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49501	hg19	N/A	enh4967	fant55972	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49502	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49503	hg19	N/A	enh4967	fant55973	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49504	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49505	hg19	N/A	enh4967	fant55974	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49506	hg19	N/A	enh4967	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79959	chr19	4056510	4067628	4056512	4067630	49507	hg19	N/A	N/A	N/A	Enhatls85784	enhancer	E_484				AGATGGAGCTCCGGATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					ZBTB7A	chr19	4043302	4066899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	929
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49508	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49509	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49510	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49511	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49512	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49513	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49514	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49515	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				GTACTCAGAAAAAGTGTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49516	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49517	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49518	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49519	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49520	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49521	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49522	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49523	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				TTAGAAATTTATTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49524	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49525	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49526	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49527	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49528	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49529	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49530	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49531	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				TTCTTGATAGATTCAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49532	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49533	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49534	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49535	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49536	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49537	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49538	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49539	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				GTTCACAGGACATTGCTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49540	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49541	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49542	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49543	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49544	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49545	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49546	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49547	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				GTCACAGCGCGCTCACGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49548	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49549	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49550	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49551	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49552	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49553	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49554	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49555	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				GACTCTTGCCTGTGTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49556	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49557	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49558	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49559	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49560	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49561	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49562	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49563	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				AAGTACACAGAGTCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49564	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49565	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49566	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49567	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49568	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49569	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49570	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49571	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				CTTTTATGCTGTTGTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49572	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49573	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49574	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49575	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49576	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49577	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49578	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49579	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				CAGGGGTTCCAGGAAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49580	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49581	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49582	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49583	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49584	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49585	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49586	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49587	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				AGAAAAGAAAAAGGCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49588	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49589	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49590	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49591	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49592	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49593	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49594	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49595	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				ATGGTCTCAATCTCCTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49596	hg19	N/A	enh102595	N/A	Enhatls85795	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49597	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49598	hg19	N/A	N/A	fant55984	Enhatls85795	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79971	chr19	4122593	4134896	4122595	4134899	49599	hg19	N/A	N/A	N/A	Enhatls85795	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	941
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49600	hg19	N/A	enh62718	N/A	N/A	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	4987				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49601	hg19	N/A	enh62718	N/A	Enhatls85796	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	5012				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49602	hg19	N/A	N/A	N/A	Enhatls85796	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					MAP2K2	chr19	4090320	4124122	9881				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4122593	4134896	4122595	4134899	49603	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_485				AATTAGTCGTGGGTGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAP2K2,GNA11"	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49604	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GGAACTCCTGGGATCCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49605	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				AATCAATGTCATCGCCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49606	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GCCTGGCTGTATTACAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49607	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GAGACGGGAGAGGAGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49608	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GAGAGGAATGGGGAAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49609	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GGAAGGAAGCACGGAGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49610	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GGAGGGTGAGAGAGAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49611	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GGGAGGATGAGAGAGAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49612	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GAGGAGGGAAAAGGCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49613	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				CAAGAGGAACAGAATGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49614	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				GGGTGGTGCTCAAGGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49615	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				CTCCTGCCTGACTCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49616	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				TCTGTCCTCCTGTGCAGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49617	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				AGGGACAGCCGGGCATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49618	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				TTTGCCGCTGCACTCCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79972	chr19	4141834	4147236	4141837	4147239	49619	hg19	N/A	enh52837	N/A	Enhatls85796	enhancer	E_486				TACTCAGGAGGCTTGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					CREB3L3	chr19	4153630	4173054	5522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	942
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49620	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				CCTGAAGCGGGGGAAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49621	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				CCTGAAGCGGGGGAAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49622	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				CCCTGCTCGGAAGGCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49623	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				CCCTGCTCGGAAGGCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49624	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				GTCAGACCTGAAGGAAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49625	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				GTCAGACCTGAAGGAAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49626	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				ACGTCGTGGGAGACTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49627	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				ACGTCGTGGGAGACTTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49628	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				CAGGAGAAGCTGCGGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49629	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				CAGGAGAAGCTGCGGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49630	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				ATACCTTTCCTTCCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49631	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				ATACCTTTCCTTCCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49632	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				AGGCAGACGGACATGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49633	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				AGGCAGACGGACATGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49634	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				TCACATCCTCCCGTGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49635	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				TCACATCCTCCCGTGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49636	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				GCAGAGTGCCACATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49637	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				GCAGAGTGCCACATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49638	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				TTGAGTCACACTCATTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49639	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				TTGAGTCACACTCATTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-79998	chr19	4227099	4231584	4227102	4231587	49640	hg19	N/A	N/A	N/A	Enhatls85823	enhancer	E_487				TCTCGCTTGAACCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	968
enhrx-79999	chr19	4227099	4231584	4227102	4231587	49641	hg19	N/A	N/A	N/A	Enhatls85824	enhancer	E_487				TCTCGCTTGAACCCAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					EBI3	chr19	4229522	4237528	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	969
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49642	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				TGTTGTTTATTTTTAGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49643	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				AGTTGAGGTTGCAGTGAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49644	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				CTGTGCCCCAGCTACTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49645	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				AGGCTGGTGTCAAAACTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49646	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				TGGTAATGCTTACCCCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49647	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				GAGTTCAAGATCTAGAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49648	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				TCAGCAGTGACACACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80097	chr19	4517184	4523070	4517172	4523058	49649	hg19	N/A	N/A	N/A	Enhatls85927	enhancer	E_489				GTATGGCAGGCTGAGCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN4	chr19	4502191	4518486	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1067
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49650	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				CAGGGGTGCCTGGACACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49651	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				CAGGGGTGCCTGGACACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49652	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				ACGCCCCCTCAACGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49653	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				ACGCCCCCTCAACGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49654	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GGCGCGGGACCGTGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49655	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GGCGCGGGACCGTGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49656	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GGGGCGCGGACCGCGGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49657	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GGGGCGCGGACCGCGGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49658	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				TCAAATATCCGGGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49659	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				TCAAATATCCGGGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49660	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				CGTGGCGCTGAGGCCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49661	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				CGTGGCGCTGAGGCCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49662	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GACTAGGGTCCTCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49663	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GACTAGGGTCCTCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49664	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GCCGGAGGCCACGTCGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49665	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GCCGGAGGCCACGTCGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49666	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GGACTTTTGCCGAGGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49667	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GGACTTTTGCCGAGGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49668	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GGGGGCGGCCTCGTACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49669	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GGGGGCGGCCTCGTACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49670	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GCTGCAGTCAGTCACACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49671	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GCTGCAGTCAGTCACACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49672	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				ATTATGAGAAGTTCGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49673	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				ATTATGAGAAGTTCGCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49674	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				TCGATATTCAAAATTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49675	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				TCGATATTCAAAATTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49676	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				CCGAGGCAGGCGGATCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49677	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				CCGAGGCAGGCGGATCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49678	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				CAGTCTGTGTATTTGTTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49679	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				CAGTCTGTGTATTTGTTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80124	chr19	4668483	4671894	4668471	4671882	49680	hg19	N/A	N/A	N/A	Enhatls85954	enhancer	E_490				GAACATCGTCTGTAACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1094
enhrx-80125	chr19	4668483	4671894	4668471	4671882	49681	hg19	N/A	N/A	N/A	Enhatls85955	enhancer	E_490				GAACATCGTCTGTAACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					MYDGF	chr19	4641373	4670362	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1095
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49682	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				GACCTCCCTACTAAAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49683	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				GACCTCCCTACTAAAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49684	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				GACCTCCCTACTAAAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49685	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				GACCTCCCTACTAAAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49686	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				AGGGAACCATGTCCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49687	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				AGGGAACCATGTCCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49688	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				AGGGAACCATGTCCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49689	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				AGGGAACCATGTCCAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49690	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				GGCCTCCTCACTGTTCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49691	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				GGCCTCCTCACTGTTCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49692	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				GGCCTCCTCACTGTTCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49693	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				GGCCTCCTCACTGTTCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49694	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				GGGCTGGGATGGCTCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49695	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				GGGCTGGGATGGCTCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49696	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				GGGCTGGGATGGCTCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49697	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				GGGCTGGGATGGCTCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49698	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				GTTAACCCTTAACTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49699	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				GTTAACCCTTAACTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49700	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				GTTAACCCTTAACTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49701	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				GTTAACCCTTAACTTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49702	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				GGTGTGGGGCAAAATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49703	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				GGTGTGGGGCAAAATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49704	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				GGTGTGGGGCAAAATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49705	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				GGTGTGGGGCAAAATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49706	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				TCTCACCCTAGGGCTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49707	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				TCTCACCCTAGGGCTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49708	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				TCTCACCCTAGGGCTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49709	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				TCTCACCCTAGGGCTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49710	hg19	N/A	enh4973	N/A	Enhatls85986	enhancer	E_492				AGGTAAGAAATAGCTACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80149	chr19	4864744	4872752	4864732	4872740	49711	hg19	N/A	N/A	N/A	Enhatls85986	enhancer	E_492				AGGTAAGAAATAGCTACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1119
enhrx-80150	chr19	4864744	4872752	4864732	4872740	49712	hg19	N/A	N/A	fant56014	N/A	enhancer	E_492				AGGTAAGAAATAGCTACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2589				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1120
enhrx-80151	chr19	4864744	4872752	4864732	4872740	49713	hg19	N/A	enh48155	N/A	N/A	enhancer	E_492				AGGTAAGAAATAGCTACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					PLIN3	chr19	4838340	4867694	2804				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49714	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				GTTTTGTGTTGTTTCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49715	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				AGGTGGACAGAGAAGGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49716	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				GCAATCCATCAATAAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49717	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				GGCATTGATCCTAAGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49718	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				GGAGACACAGGATCTGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49719	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				CACAATATCACAGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49720	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				ATGATCGTGCTACTGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80151	chr19	4887203	4891176	4887191	4891164	49721	hg19	N/A	N/A	N/A	Enhatls85987	enhancer	E_493				CACTTGAGTCTGGGAGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					ARRDC5	chr19	4890436	4902896	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1121
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49722	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				GGCAGTAGGAATGTCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49723	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				GAGACGCAAATCCAGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49724	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				TCTGGGAAAATCCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49725	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				CAGCCCAGGCAGGTGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49726	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				TGTGCGGCGCAGACACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49727	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				CAGATGAGCAATGTAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49728	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				CGCCTCTTCAGTGCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49729	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				TTGGAGCCGGGCCAGGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49730	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				TGTTACTACAGAGAACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49731	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				TCCCCTGAAATCTAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49732	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				GAGACTCTCCATGTCCACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49733	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				ATGAGGCCGGTCCCAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80166	chr19	5036505	5039080	5036494	5039069	49734	hg19	N/A	enh4975	N/A	Enhatls86003	enhancer	E_494				CATGAGGTAGATGGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1136
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49735	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GCTGGGCGCAAATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49736	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GCTGGGCGCAAATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49737	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCTGGGCGCAAATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49738	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GCTGGGCGCAAATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49739	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCTGGGCGCAAATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49740	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GGCAGTGATGAGACCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49741	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GGCAGTGATGAGACCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49742	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GGCAGTGATGAGACCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49743	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GGCAGTGATGAGACCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49744	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GGCAGTGATGAGACCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49745	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CTCAGACTTGGCAAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49746	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CTCAGACTTGGCAAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49747	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCAGACTTGGCAAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49748	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CTCAGACTTGGCAAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49749	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCAGACTTGGCAAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49750	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				AGCTCACGTTCATGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49751	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				AGCTCACGTTCATGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49752	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				AGCTCACGTTCATGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49753	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				AGCTCACGTTCATGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49754	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				AGCTCACGTTCATGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49755	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GCAGGCCATGAGCCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49756	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GCAGGCCATGAGCCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49757	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCAGGCCATGAGCCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49758	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GCAGGCCATGAGCCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49759	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCAGGCCATGAGCCTCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49760	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				TTAAGAATAGATGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49761	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				TTAAGAATAGATGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49762	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TTAAGAATAGATGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49763	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				TTAAGAATAGATGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49764	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TTAAGAATAGATGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49765	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CCTTCCACAGCTTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49766	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CCTTCCACAGCTTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49767	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CCTTCCACAGCTTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49768	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CCTTCCACAGCTTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49769	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CCTTCCACAGCTTCTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49770	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				ACTTGGGGCTAACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49771	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				ACTTGGGGCTAACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49772	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				ACTTGGGGCTAACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49773	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				ACTTGGGGCTAACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49774	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				ACTTGGGGCTAACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49775	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CAGCGTGCACCAGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49776	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CAGCGTGCACCAGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49777	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CAGCGTGCACCAGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49778	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CAGCGTGCACCAGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49779	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CAGCGTGCACCAGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49780	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				TGTGCTGCCTCACAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49781	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				TGTGCTGCCTCACAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49782	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TGTGCTGCCTCACAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49783	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				TGTGCTGCCTCACAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49784	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TGTGCTGCCTCACAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49785	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GCCAGGCCCTACAGTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49786	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GCCAGGCCCTACAGTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49787	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCCAGGCCCTACAGTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49788	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GCCAGGCCCTACAGTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49789	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCCAGGCCCTACAGTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49790	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				ACCCGGCACCTCCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49791	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				ACCCGGCACCTCCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49792	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				ACCCGGCACCTCCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49793	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				ACCCGGCACCTCCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49794	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				ACCCGGCACCTCCCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49795	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GCCTCGCTGCGACGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49796	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GCCTCGCTGCGACGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49797	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCCTCGCTGCGACGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49798	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GCCTCGCTGCGACGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49799	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCCTCGCTGCGACGTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49800	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				AACCTGCTGGGTGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49801	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				AACCTGCTGGGTGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49802	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				AACCTGCTGGGTGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49803	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				AACCTGCTGGGTGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49804	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				AACCTGCTGGGTGCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49805	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CTCCGTCCTCCTCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49806	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CTCCGTCCTCCTCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49807	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCCGTCCTCCTCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49808	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CTCCGTCCTCCTCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49809	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCCGTCCTCCTCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49810	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CCGCTTACAACTCCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49811	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CCGCTTACAACTCCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49812	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CCGCTTACAACTCCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49813	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CCGCTTACAACTCCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49814	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CCGCTTACAACTCCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49815	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				TAAAAAAAAGCACAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49816	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				TAAAAAAAAGCACAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49817	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TAAAAAAAAGCACAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49818	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				TAAAAAAAAGCACAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49819	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				TAAAAAAAAGCACAATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49820	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GTGTGACTTGGGGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49821	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GTGTGACTTGGGGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49822	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GTGTGACTTGGGGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49823	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GTGTGACTTGGGGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49824	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GTGTGACTTGGGGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49825	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GCACAAACCCGGTCACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49826	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GCACAAACCCGGTCACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49827	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCACAAACCCGGTCACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49828	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GCACAAACCCGGTCACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49829	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GCACAAACCCGGTCACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49830	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				GAAGTGGCGAGCAGCCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49831	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				GAAGTGGCGAGCAGCCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49832	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GAAGTGGCGAGCAGCCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49833	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				GAAGTGGCGAGCAGCCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49834	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				GAAGTGGCGAGCAGCCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49835	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CTCACGTCTGACTCACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49836	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CTCACGTCTGACTCACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49837	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCACGTCTGACTCACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49838	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CTCACGTCTGACTCACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49839	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCACGTCTGACTCACTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49840	hg19	N/A	enh4976	N/A	Enhatls86005	enhancer	E_495				CTCACAGGAGACCGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49841	hg19	N/A	enh4976	N/A	N/A	enhancer	E_495				CTCACAGGAGACCGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49842	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCACAGGAGACCGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49843	hg19	N/A	enh4976	fant56021	Enhatls86006	enhancer	E_495				CTCACAGGAGACCGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80168	chr19	5046212	5050252	5046201	5050241	49844	hg19	N/A	enh4976	N/A	Enhatls86006	enhancer	E_495				CTCACAGGAGACCGAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP2K2	direct	Highly Significant	NA					KDM4B	chr19	4969112	5153598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1138
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49845	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				GCAAGGGTCTTCGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49846	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				GCAAGGGTCTTCGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49847	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GCAAGGGTCTTCGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49848	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				GCAAGGGTCTTCGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49849	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GCAAGGGTCTTCGTTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49850	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				CAGGAGTGCACGGTCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49851	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				CAGGAGTGCACGGTCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49852	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CAGGAGTGCACGGTCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49853	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				CAGGAGTGCACGGTCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49854	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CAGGAGTGCACGGTCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49855	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				CGCGCCGTCGGGCGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49856	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				CGCGCCGTCGGGCGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49857	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CGCGCCGTCGGGCGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49858	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				CGCGCCGTCGGGCGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49859	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CGCGCCGTCGGGCGGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49860	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				GTGCTGTTCCGCTACTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49861	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				GTGCTGTTCCGCTACTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49862	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GTGCTGTTCCGCTACTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49863	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				GTGCTGTTCCGCTACTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49864	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GTGCTGTTCCGCTACTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49865	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				TGCGACGACTGCGCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49866	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				TGCGACGACTGCGCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49867	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				TGCGACGACTGCGCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49868	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				TGCGACGACTGCGCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49869	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				TGCGACGACTGCGCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49870	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				CGTCCTCGTAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49871	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				CGTCCTCGTAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49872	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CGTCCTCGTAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49873	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				CGTCCTCGTAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49874	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CGTCCTCGTAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49875	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				AGTGAGGTAGGGTCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49876	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				AGTGAGGTAGGGTCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49877	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AGTGAGGTAGGGTCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49878	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				AGTGAGGTAGGGTCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49879	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AGTGAGGTAGGGTCACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49880	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				CAGTTATCGCGAGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49881	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				CAGTTATCGCGAGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49882	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CAGTTATCGCGAGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49883	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				CAGTTATCGCGAGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49884	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				CAGTTATCGCGAGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49885	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				GCCACGTCGCCGTCTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49886	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				GCCACGTCGCCGTCTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49887	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GCCACGTCGCCGTCTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49888	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				GCCACGTCGCCGTCTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49889	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				GCCACGTCGCCGTCTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49890	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				AAAGTGGGTCCAGTTTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49891	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				AAAGTGGGTCCAGTTTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49892	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AAAGTGGGTCCAGTTTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49893	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				AAAGTGGGTCCAGTTTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49894	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AAAGTGGGTCCAGTTTATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49895	hg19	N/A	N/A	fant56051	Enhatls86145	enhancer	E_496				AACACGCTCGGGACGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80297	chr19	5826937	5830424	5826926	5830413	49896	hg19	N/A	N/A	N/A	Enhatls86145	enhancer	E_496				AACACGCTCGGGACGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49897	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AACACGCTCGGGACGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49898	hg19	N/A	N/A	fant56052	Enhatls86146	enhancer	E_496				AACACGCTCGGGACGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					NRTN	chr19	5805066	5828324	761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80298	chr19	5826937	5830424	5826926	5830413	49899	hg19	N/A	N/A	N/A	Enhatls86146	enhancer	E_496				AACACGCTCGGGACGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					FUT6	chr19	5830407	5839717	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49900	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				GAGATAACTGCGCATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49901	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				GAGATAACTGCGCATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49902	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				GAGATAACTGCGCATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49903	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				AGCGCATGTGCAAGTTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49904	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				AGCGCATGTGCAAGTTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49905	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				AGCGCATGTGCAAGTTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49906	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				GTTGGAACAATATGGCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49907	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				GTTGGAACAATATGGCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49908	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				GTTGGAACAATATGGCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49909	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				TTTTCTTATCCAGCAAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49910	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				TTTTCTTATCCAGCAAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49911	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				TTTTCTTATCCAGCAAACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49912	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				TGGGTACTCAACCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49913	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				TGGGTACTCAACCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49914	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				TGGGTACTCAACCTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49915	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				CCCCGTTCTCCCTCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3357				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49916	hg19	N/A	enh32880	fant56063	Enhatls86178	enhancer	E_497				CCCCGTTCTCCCTCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	3260				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80327	chr19	5984526	5990493	5984515	5990482	49917	hg19	N/A	enh32880	N/A	Enhatls86178	enhancer	E_497				CCCCGTTCTCCCTCAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					RFX2	chr19	5993163	6199529	473				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1297
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49918	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				GCTACTAACCCACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49919	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				GCTACTAACCCACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49920	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				GCTACTAACCCACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49921	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				GCTACTAACCCACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49922	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				GCTACTAACCCACCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49923	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CATGGTGCTGGGACAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49924	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CATGGTGCTGGGACAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49925	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CATGGTGCTGGGACAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49926	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CATGGTGCTGGGACAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49927	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CATGGTGCTGGGACAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49928	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CCCAAAAGGGGAGAGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49929	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CCCAAAAGGGGAGAGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49930	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CCCAAAAGGGGAGAGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49931	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CCCAAAAGGGGAGAGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49932	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CCCAAAAGGGGAGAGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49933	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CCATGGGGTGAGTAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49934	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CCATGGGGTGAGTAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49935	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CCATGGGGTGAGTAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49936	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CCATGGGGTGAGTAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49937	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CCATGGGGTGAGTAACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49938	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CACCAGGTGGCCCTGACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49939	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CACCAGGTGGCCCTGACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49940	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CACCAGGTGGCCCTGACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49941	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CACCAGGTGGCCCTGACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49942	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CACCAGGTGGCCCTGACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49943	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CTGTTGGACCCACTTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49944	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CTGTTGGACCCACTTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49945	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CTGTTGGACCCACTTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49946	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CTGTTGGACCCACTTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49947	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CTGTTGGACCCACTTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49948	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				GCATGGCCAAAAGTGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49949	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				GCATGGCCAAAAGTGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49950	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				GCATGGCCAAAAGTGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49951	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				GCATGGCCAAAAGTGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49952	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				GCATGGCCAAAAGTGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	direct	Highly Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49953	hg19	N/A	enh57725	N/A	Enhatls86325	enhancer	E_500				CTAGGAATCTCTCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	indirect	Non Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49954	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CTAGGAATCTCTCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	indirect	Non Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49955	hg19	N/A	enh57725	N/A	Enhatls86326	enhancer	E_500				CTAGGAATCTCTCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	indirect	Non Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80467	chr19	6719208	6724667	6719197	6724656	49956	hg19	N/A	enh57725	N/A	N/A	enhancer	E_500				CTAGGAATCTCTCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	indirect	Non Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1437
enhrx-80468	chr19	6719208	6724667	6719197	6724656	49957	hg19	N/A	enh92820	N/A	N/A	enhancer	E_500				CTAGGAATCTCTCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VAV1	indirect	Non Significant	NA					C3	chr19	6677703	6730562	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1438
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49958	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				GGGACCGGATCCGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49959	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				GGGACCGGATCCGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49960	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				GGGACCGGATCCGCATCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49961	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				GGTAAGAGAAGATCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49962	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				GGTAAGAGAAGATCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49963	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				GGTAAGAGAAGATCTCGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49964	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				TTCCGGTTAAAGAGACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49965	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				TTCCGGTTAAAGAGACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49966	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				TTCCGGTTAAAGAGACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49967	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				TCCCAGGGCCGGACCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49968	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				TCCCAGGGCCGGACCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49969	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				TCCCAGGGCCGGACCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49970	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				AGTGAGAGGCTTGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49971	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				AGTGAGAGGCTTGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49972	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				AGTGAGAGGCTTGCGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49973	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				GTGAGGCGAAGCTCGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49974	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				GTGAGGCGAAGCTCGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49975	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				GTGAGGCGAAGCTCGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49976	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				ACGCCTTCCGGACTTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49977	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				ACGCCTTCCGGACTTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49978	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				ACGCCTTCCGGACTTGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49979	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				CTGGGGAGGGGCGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49980	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				CTGGGGAGGGGCGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49981	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				CTGGGGAGGGGCGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49982	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				AGAACGGAACCAAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49983	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				AGAACGGAACCAAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49984	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				AGAACGGAACCAAGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49985	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				AGCGGGGCGAGGCCTAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49986	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				AGCGGGGCGAGGCCTAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49987	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				AGCGGGGCGAGGCCTAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49988	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				GTAGAGGCTCGGACAACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49989	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				GTAGAGGCTCGGACAACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49990	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				GTAGAGGCTCGGACAACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	indirect	Non Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49991	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				AGGACCAGGCGCCAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49992	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				AGGACCAGGCGCCAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49993	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				AGGACCAGGCGCCAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49994	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				AAGACTACGCCATGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49995	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				AAGACTACGCCATGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49996	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				AAGACTACGCCATGAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	49997	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				TTTGTATTACTGGAATATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	49998	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				TTTGTATTACTGGAATATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	49999	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				TTTGTATTACTGGAATATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	50000	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				CACACATTTTTATAGTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	50001	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				CACACATTTTTATAGTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	50002	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				CACACATTTTTATAGTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81093	chr19	9928657	9931172	9817981	9820496	50003	hg19	N/A	N/A	N/A	Enhatls86965	enhancer	E_501				ACGCAGCCTGTTGGTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2063
enhrx-81094	chr19	9928657	9931172	9817981	9820496	50004	hg19	N/A	N/A	N/A	Enhatls86966	enhancer	E_501				ACGCAGCCTGTTGGTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2064
enhrx-81095	chr19	9928657	9931172	9817981	9820496	50005	hg19	N/A	enh104514	N/A	N/A	enhancer	E_501				ACGCAGCCTGTTGGTTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,ICAM3"	direct	Highly Significant	NA					FBXL12	chr19	9810266	9827816	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2065
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50006	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50007	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50008	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50009	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50010	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50011	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				ACTTTGGGAGACCAAGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50012	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50013	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50014	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50015	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50016	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50017	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				TTTTTCTTTTTTAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50018	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50019	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50020	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50021	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50022	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50023	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				TGGGATCGGGAAAGAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50024	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50025	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50026	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50027	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50028	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50029	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				GGACGGTTGTGCTTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50030	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50031	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50032	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50033	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50034	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50035	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				GATTCATGATGACTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81188	chr19	10226852	10233990	10116176	10123314	50036	hg19	N/A	N/A	N/A	Enhatls87059	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-81189	chr19	10226852	10233990	10116176	10123314	50037	hg19	N/A	N/A	N/A	Enhatls87060	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2159
enhrx-81190	chr19	10226852	10233990	10116176	10123314	50038	hg19	N/A	N/A	N/A	Enhatls87061	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2160
enhrx-81191	chr19	10226852	10233990	10116176	10123314	50039	hg19	N/A	N/A	N/A	Enhatls87062	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2161
enhrx-81192	chr19	10226852	10233990	10116176	10123314	50040	hg19	N/A	N/A	N/A	Enhatls87063	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2162
enhrx-81193	chr19	10226852	10233990	10116176	10123314	50041	hg19	N/A	N/A	N/A	Enhatls87064	enhancer	E_502				AGGCAGAAACTAAATACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					EIF3G	chr19	10115013	10119899	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2163
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50042	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				CACTTCAGCCTGGGCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50043	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				CACTTCAGCCTGGGCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50044	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				CACTTCAGCCTGGGCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50045	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				CACTTCAGCCTGGGCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50046	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				ATTCCTAGTCACATCTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50047	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				ATTCCTAGTCACATCTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50048	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				ATTCCTAGTCACATCTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50049	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				ATTCCTAGTCACATCTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50050	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				TAGGGCATCTTTCTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50051	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				TAGGGCATCTTTCTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50052	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				TAGGGCATCTTTCTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50053	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				TAGGGCATCTTTCTCCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50054	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				ATACCAGCCCTAAGTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50055	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				ATACCAGCCCTAAGTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50056	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				ATACCAGCCCTAAGTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50057	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				ATACCAGCCCTAAGTCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50058	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				GTGTCTTTCACCCTGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50059	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				GTGTCTTTCACCCTGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50060	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				GTGTCTTTCACCCTGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50061	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				GTGTCTTTCACCCTGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50062	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				GATGGCACTTCCCCACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50063	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				GATGGCACTTCCCCACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50064	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				GATGGCACTTCCCCACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50065	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				GATGGCACTTCCCCACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50066	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				CCAATGGGGGCCTCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50067	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				CCAATGGGGGCCTCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50068	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				CCAATGGGGGCCTCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50069	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				CCAATGGGGGCCTCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50070	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				AGGCCTATTACCCGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50071	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				AGGCCTATTACCCGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50072	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				AGGCCTATTACCCGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50073	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				AGGCCTATTACCCGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50074	hg19	N/A	enh86301	N/A	Enhatls87177	enhancer	E_503				GGCTGTCTTGGACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81309	chr19	10594381	10600242	10483705	10489566	50075	hg19	N/A	N/A	N/A	Enhatls87177	enhancer	E_503				GGCTGTCTTGGACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	11				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2279
enhrx-81310	chr19	10594381	10600242	10483705	10489566	50076	hg19	N/A	N/A	N/A	Enhatls87178	enhancer	E_503				GGCTGTCTTGGACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2280
enhrx-81311	chr19	10594381	10600242	10483705	10489566	50077	hg19	N/A	N/A	N/A	Enhatls87179	enhancer	E_503				GGCTGTCTTGGACACTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KEAP1	chr19	10486124	10503356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2281
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50078	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCAGTATGAGAGGCCGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50079	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCAGTATGAGAGGCCGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50080	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCAGTATGAGAGGCCGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50081	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				CCTCCTTCCCCACTAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50082	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				CCTCCTTCCCCACTAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50083	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				CCTCCTTCCCCACTAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50084	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				CTAAGCTAATTAATGGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50085	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				CTAAGCTAATTAATGGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50086	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				CTAAGCTAATTAATGGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50087	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCGGCGAGGCCTATTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50088	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCGGCGAGGCCTATTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50089	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCGGCGAGGCCTATTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50090	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GACCGGGCAGTGGTTTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50091	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GACCGGGCAGTGGTTTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50092	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GACCGGGCAGTGGTTTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50093	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCCGTGGGGTCCGTGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50094	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCCGTGGGGTCCGTGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50095	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCCGTGGGGTCCGTGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50096	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCGCAGAGCGGACGCCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50097	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCGCAGAGCGGACGCCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50098	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCGCAGAGCGGACGCCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50099	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCGAAGCGTGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50100	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCGAAGCGTGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50101	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCGAAGCGTGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50102	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				CGTGCGCGCCCGTCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50103	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				CGTGCGCGCCCGTCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50104	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				CGTGCGCGCCCGTCCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50105	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				CCTCCCCCTCAGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50106	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				CCTCCCCCTCAGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50107	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				CCTCCCCCTCAGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50108	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GGCTTCCCCTCGTTTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50109	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GGCTTCCCCTCGTTTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50110	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GGCTTCCCCTCGTTTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50111	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GGGAGGCGCCGGGAAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50112	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GGGAGGCGCCGGGAAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50113	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GGGAGGCGCCGGGAAGTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50114	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GAGGGCGGTTTGAATGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50115	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GAGGGCGGTTTGAATGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50116	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GAGGGCGGTTTGAATGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50117	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				GCCACAGTGTCGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50118	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				GCCACAGTGTCGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50119	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				GCCACAGTGTCGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50120	hg19	N/A	enh5004	N/A	N/A	enhancer	E_504				CTCCGCGCGCGCTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50121	hg19	N/A	enh5004	N/A	Enhatls87308	enhancer	E_504				CTCCGCGCGCGCTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81434	chr19	11070435	11076378	10959759	10965702	50122	hg19	N/A	N/A	N/A	Enhatls87308	enhancer	E_504				CTCCGCGCGCGCTCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SMARCA4	chr19	10960931	11079426	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2404
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50123	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GAGGGTCGGAGCGTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50124	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GAGGGTCGGAGCGTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50125	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GCTGGGCGCCAACCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50126	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GCTGGGCGCCAACCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50127	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GCGGACAGTCAAATTTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50128	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GCGGACAGTCAAATTTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50129	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GATACGTCAGTCATAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50130	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GATACGTCAGTCATAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50131	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GCACCAGGCCAGACCAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50132	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GCACCAGGCCAGACCAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50133	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				AGGCGCATCGGGAAGGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50134	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				AGGCGCATCGGGAAGGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50135	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				CGCTTGCTCTGTGCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50136	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				CGCTTGCTCTGTGCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50137	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				GAATAAGTAGATTCTATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50138	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				GAATAAGTAGATTCTATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50139	hg19	N/A	enh81487	N/A	Enhatls87356	enhancer	E_506				AGAGAGGTGAAGTCTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81478	chr19	11261863	11270152	11151187	11159476	50140	hg19	N/A	N/A	N/A	Enhatls87356	enhancer	E_506				AGAGAGGTGAAGTCTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					SPC24	chr19	11131519	11155782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2448
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50141	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				GTAAGAGACACAATCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50142	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				CAGTTCTAGGTAGTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50143	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				TGGTGACTAAGACACGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50144	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				TGTGACTAATTTCCTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50145	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				TCATAAACATCCGTCTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11278869	11279656	11168193	11168980	50146	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_507				AGGAAGCATGGCTTAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50147	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				GTAAGAGACACAATCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50148	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				GTAAGAGACACAATCAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50149	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				CAGTTCTAGGTAGTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50150	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				CAGTTCTAGGTAGTCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50151	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				TGGTGACTAAGACACGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50152	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				TGGTGACTAAGACACGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50153	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				TGTGACTAATTTCCTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50154	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				TGTGACTAATTTCCTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50155	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				TCATAAACATCCGTCTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50156	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				TCATAAACATCCGTCTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50157	hg19	N/A	enh94985	N/A	Enhatls87358	enhancer	E_508				AGGAAGCATGGCTTAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81480	chr19	11279668	11280658	11168992	11169982	50158	hg19	N/A	N/A	N/A	Enhatls87358	enhancer	E_508				AGGAAGCATGGCTTAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2450
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50159	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50160	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50161	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50162	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50163	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50164	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50165	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CTGGAAAGTTTGGGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50166	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50167	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50168	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50169	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50170	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50171	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50172	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				GCGGCTCGTTGAGACCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50173	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50174	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50175	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50176	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50177	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50178	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50179	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				GCGCGAAGACGCTCGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50180	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50181	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50182	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50183	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50184	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50185	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50186	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				GCTGGTCCCGCCCCCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50187	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50188	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50189	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50190	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50191	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50192	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50193	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CCCCGGCCGCGGTGGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50194	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50195	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50196	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50197	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50198	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50199	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50200	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				AAGGACGAGGCCGGACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50201	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50202	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50203	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50204	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50205	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50206	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50207	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				AGCCGTTCCGCCCCCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50208	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50209	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50210	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50211	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50212	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50213	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50214	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CGGGAGGTCACCCCTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50215	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50216	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50217	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50218	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50219	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50220	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50221	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				TGACCGCCGCGCGAGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50222	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50223	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50224	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50225	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50226	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50227	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50228	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				AGCAAAAGTTTGGTGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50229	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50230	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50231	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50232	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50233	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50234	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50235	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				ATTCACTGACCATTAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50236	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50237	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50238	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50239	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50240	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50241	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50242	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				AGAAAGATCTCTGCAAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50243	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50244	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50245	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50246	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50247	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50248	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50249	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				TTCGGGGGGGCTGGAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50250	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50251	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50252	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50253	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50254	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50255	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50256	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				GGCTGGAAGCTGGGTACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50257	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50258	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50259	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50260	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50261	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50262	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50263	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				TCTCTCCCCAGTCTATCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50264	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50265	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50266	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50267	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50268	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50269	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50270	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CACAAGCTGCCCTCGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50271	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50272	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50273	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50274	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50275	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50276	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50277	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CACCAGAGGAGCATGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50278	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50279	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50280	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50281	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50282	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50283	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50284	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				AGTCATCACGGGGGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50285	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50286	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50287	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50288	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50289	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50290	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50291	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				GTCAAGGTCAGCAGATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50292	hg19	N/A	enh17923	N/A	Enhatls87364	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81486	chr19	11300864	11315871	11190188	11205195	50293	hg19	N/A	enh17923	N/A	N/A	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2456
enhrx-81487	chr19	11300864	11315871	11190188	11205195	50294	hg19	N/A	N/A	N/A	Enhatls87365	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2457
enhrx-81488	chr19	11300864	11315871	11190188	11205195	50295	hg19	N/A	N/A	fant56265	N/A	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					KANK2	chr19	11164269	11197548	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2458
enhrx-81489	chr19	11300864	11315871	11190188	11205195	50296	hg19	N/A	N/A	N/A	Enhatls87366	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2459
enhrx-81490	chr19	11300864	11315871	11190188	11205195	50297	hg19	N/A	N/A	N/A	Enhatls87367	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2460
enhrx-81491	chr19	11300864	11315871	11190188	11205195	50298	hg19	N/A	N/A	N/A	Enhatls87368	enhancer	E_509				CACCAAGATCATGCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"KEAP1,SMARCA4,ICAM3"	direct	Highly Significant	NA					DOCK6	chr19	11199294	11262524	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2461
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50299	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				CTGTAATTCAGCTACTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50300	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				ACTCGGCCTGAGAGGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50301	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				CGTAGGAAGCCATGGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50302	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				GGCCCATCTGAATGGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50303	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				GCAGGGCCTGCGCCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50304	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				GCCGTGACCTGTACAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50305	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				TCAGGCGTCCCCAGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50306	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				GAGGGACCTAGGCCTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50307	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				ACACGAACCACATCCGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50308	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				CGGGAGAAAGGCGGGACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50309	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				AGCAAACAGCGGCTCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81604	chr19	11706795	11710460	11595980	11599645	50310	hg19	N/A	N/A	N/A	Enhatls87483	enhancer	E_510				GATCCGTTGGAGGGAATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2574
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50311	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				CCCCTTCTGCTCCGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50312	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				TTGTGACCCCCCAGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50313	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				ACACAGCTCTTGGCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50314	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				GGGTGACAGAGAAGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50315	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				GAACCTGTACTGGCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50316	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				GTACCCTGTCTCGGGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50317	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				CCCCAGAGACAACAGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50318	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				GGCAACTGCGGCCCAGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50319	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				GGGGAATCCTCCTCGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50320	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				CAGTAAAAACTCGAGCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50321	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				AAATCCGCAACTGTGATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50322	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				AGGAGGCCAGCTCTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81607	chr19	11750175	11751313	11639360	11640498	50323	hg19	N/A	enh116196	N/A	Enhatls87486	enhancer	E_511				ATGTCAACTCTTCGTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF627	chr19	11559447	11619161	18380				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2577
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50324	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCAAAACTCCTGATTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50325	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				CCAAAACTCCTGATTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50326	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCAAAACTCCTGATTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	indirect	Non Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50327	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCTTCCTGCTCTCAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50328	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				CCTTCCTGCTCTCAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50329	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCTTCCTGCTCTCAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50330	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TGTGACCTGACCCCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50331	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				TGTGACCTGACCCCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50332	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TGTGACCTGACCCCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50333	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TTCCGTTACTCAGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50334	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				TTCCGTTACTCAGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50335	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TTCCGTTACTCAGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50336	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CAGAACCCGGAGCCCAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50337	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				CAGAACCCGGAGCCCAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50338	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CAGAACCCGGAGCCCAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50339	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GTGGCAGCTTCTGTCTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50340	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				GTGGCAGCTTCTGTCTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50341	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GTGGCAGCTTCTGTCTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50342	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CAGTCTCTCCTCTCACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50343	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				CAGTCTCTCCTCTCACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50344	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CAGTCTCTCCTCTCACGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50345	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TCGTGCGGCCGAGGGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50346	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				TCGTGCGGCCGAGGGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50347	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				TCGTGCGGCCGAGGGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50348	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GCTGCCCAGACAGGCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50349	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				GCTGCCCAGACAGGCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50350	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GCTGCCCAGACAGGCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50351	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCAGATTGTGCGGCTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50352	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				CCAGATTGTGCGGCTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50353	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				CCAGATTGTGCGGCTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50354	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				AACAGTTTAATAGGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50355	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				AACAGTTTAATAGGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50356	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				AACAGTTTAATAGGGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50357	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GACAGGGGCGGCTGGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50358	hg19	N/A	N/A	fant56283	Enhatls87494	enhancer	E_512				GACAGGGGCGGCTGGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81614	chr19	11877111	11879450	11766296	11768635	50359	hg19	N/A	N/A	N/A	Enhatls87494	enhancer	E_512				GACAGGGGCGGCTGGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCA4	direct	Highly Significant	NA					ZNF441	chr19	11766999	11784078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2584
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50360	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				TAGAAGCTTAAACTGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50361	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				GGAAGCGGTTCCATATTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50362	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				TCATTCCTTTGCCTCATAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50363	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				GATCTTTCAGAAATGTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50364	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				GAGTGAGCTTAGCCTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50365	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				TGCTTCCCCGGATTGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50366	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				TGACAGCGTCACAGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50367	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				CGGCCTAGCGTCCAGATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50368	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				GACGCGGGTCCCAATCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50369	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				GGGGCCGCAGTCGCCGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81618	chr19	11909192	11910168	11798377	11799353	50370	hg19	N/A	N/A	N/A	Enhatls87498	enhancer	E_513				TCTGGGAAGACGCCGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF491	chr19	11798522	11808503	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2588
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50371	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				GCTTGGTTAGCTCCCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50372	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				GCTTGGTTAGCTCCCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50373	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				AGCGTGCGGGAAATGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50374	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				AGCGTGCGGGAAATGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50375	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				ACGCTTGCCTCAGAGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50376	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				ACGCTTGCCTCAGAGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50377	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				CACTTGTGATCCCGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50378	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				CACTTGTGATCCCGTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50379	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				ATGCAAATATCTGATGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50380	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				ATGCAAATATCTGATGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50381	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				CTGCTCGCTCAGAGACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50382	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				CTGCTCGCTCAGAGACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50383	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				TCTGCTGTCACTCAGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50384	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				TCTGCTGTCACTCAGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50385	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				CTTTAGTGCTGCGCCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50386	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				CTTTAGTGCTGCGCCGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50387	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				TAGTCGCGGGAGCCACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50388	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				TAGTCGCGGGAGCCACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50389	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				CGTCCGGGCGACTGGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50390	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				CGTCCGGGCGACTGGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50391	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				ACGCGAGTCCCCTCGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50392	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				ACGCGAGTCCCCTCGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50393	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				GAGCTGCCCAGATTAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50394	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				GAGCTGCCCAGATTAGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50395	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				AACAAACCCCATATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50396	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				AACAAACCCCATATCCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50397	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				CAGCGAGCGGGGTAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50398	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				CAGCGAGCGGGGTAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50399	hg19	N/A	N/A	N/A	Enhatls87501	enhancer	E_514				TGTCCTTTCCTCATTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81621	chr19	11924263	11926056	11813448	11815241	50400	hg19	N/A	N/A	fant56284	Enhatls87501	enhancer	E_514				TGTCCTTTCCTCATTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF440	chr19	11814272	11835216	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2591
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50401	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				GGGATGGGGGTGTGTGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50402	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				AGGGGAACCGAGACCAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50403	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				CCCCGTGCAGAACGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50404	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				TCTTATATCTGTAGCAAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50405	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				CCGCTGTCACTCAGAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50406	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				ATACAGCGGATATCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50407	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				CTGTGCCCTTCTGTAGTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50408	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				TAGCCGGTTGTCCCGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50409	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				GCGGGACCCGGGCCTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50410	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				GCCAGCCCAGCCCCATCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50411	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				CGGTGACTGCGGCCCCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81633	chr19	12075084	12076705	11964269	11965890	50412	hg19	N/A	N/A	N/A	Enhatls87513	enhancer	E_515				GATTATGCGGAAGCCACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF763	chr19	11965036	11980617	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2603
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50413	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GATCCCCCATGACCCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50414	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GCTGCTCAGAGAGGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50415	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GCCGGCCCAGCTCCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50416	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GAGAGGAACCCGCTGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50417	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				TGTTCACGGGACCTTTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50418	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GGGGCTTTCTTGCTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50419	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				TAGCGCCCCTGATTGGATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50420	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GTGGCCAGAACCAGTCGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50421	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				CAAATATTCGAAGTAAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81640	chr19	12162779	12163944	12051964	12053129	50422	hg19	N/A	N/A	N/A	Enhatls87520	enhancer	E_516				GTGTCCCGTGTAGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,SMARCA4"	direct	Highly Significant	NA					ZNF878	chr19	12043804	12052961	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2610
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50423	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				ATGCTTCCAAAGGAAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50424	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				ATGCTTCCAAAGGAAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50425	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				CAAAAATATTAGCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50426	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				CAAAAATATTAGCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50427	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				GGGACAATCCCCTCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50428	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				GGGACAATCCCCTCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50429	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				AACAAAAAAACAGAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50430	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				AACAAAAAAACAGAAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50431	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				GAGGGTGTGTCAAAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50432	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				GAGGGTGTGTCAAAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50433	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				ATGGGATGAGTCATGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50434	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				ATGGGATGAGTCATGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50435	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				AAGAGCAACCAACATTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50436	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				AAGAGCAACCAACATTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50437	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				AAAGCGTCTTAAAGCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50438	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				AAAGCGTCTTAAAGCTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50439	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				TCTAAAACAGCGCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50440	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				TCTAAAACAGCGCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50441	hg19	N/A	enh86302	N/A	Enhatls87539	enhancer	E_517				GGGTGCTACTCGGGAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81659	chr19	12399015	12402216	12288200	12291401	50442	hg19	N/A	N/A	N/A	Enhatls87539	enhancer	E_517				GGGTGCTACTCGGGAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF44	chr19	12243143	12294883	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2629
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50443	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				GGAGGGTCACGGAAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50444	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				GGAGGGTCACGGAAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50445	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				GGAGGGTCACGGAAGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50446	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				GGCAACTGCGGTCCCGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50447	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				GGCAACTGCGGTCCCGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50448	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				GGCAACTGCGGTCCCGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50449	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				TCTGTGGCTGAGGGGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50450	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				TCTGTGGCTGAGGGGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50451	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				TCTGTGGCTGAGGGGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50452	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				GGGGAGGCCCACGTTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50453	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				GGGGAGGCCCACGTTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50454	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				GGGGAGGCCCACGTTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50455	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				GAGACGCCCTGGAACGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50456	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				GAGACGCCCTGGAACGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50457	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				GAGACGCCCTGGAACGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50458	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				CTGAGTCTAGAGCTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50459	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				CTGAGTCTAGAGCTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50460	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				CTGAGTCTAGAGCTGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50461	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				CCAATCAGAGCTATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50462	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				CCAATCAGAGCTATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50463	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				CCAATCAGAGCTATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50464	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				TCACACAGTGCTGAGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50465	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				TCACACAGTGCTGAGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50466	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				TCACACAGTGCTGAGTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50467	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				GTGCTGTCCTGATCCCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50468	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				GTGCTGTCCTGATCCCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50469	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				GTGCTGTCCTGATCCCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50470	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				CTTGTGACTCCTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50471	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				CTTGTGACTCCTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50472	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				CTTGTGACTCCTTCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50473	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				CTGCTCTGAGGCCAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50474	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				CTGCTCTGAGGCCAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50475	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				CTGCTCTGAGGCCAGGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50476	hg19	N/A	enh52849	N/A	Enhatls87544	enhancer	E_518				TTTGAGGATGAGACTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81664	chr19	12443250	12445041	12332436	12334227	50477	hg19	N/A	N/A	N/A	Enhatls87544	enhancer	E_518				TTTGAGGATGAGACTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2634
enhrx-81665	chr19	12443250	12445041	12332436	12334227	50478	hg19	N/A	N/A	N/A	Enhatls87545	enhancer	E_518				TTTGAGGATGAGACTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JUNB	direct	Highly Significant	NA					ZNF563	chr19	12317476	12333720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2635
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50479	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				CCAACAGTCTCACACCTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50480	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				AGGCCTGGCCCCTCACTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50481	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				AGGTGGAGGATCCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50482	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				CCAGCACTGTTCTTGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50483	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				GGAGGCGCGGCCCAACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50484	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				CTCCGCGTAGGTCCCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50485	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				GAAACCGGGCCGCCGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50486	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				CCCCGGAGGAAACCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50487	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				CCCGGGTCCCCAGAGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81833	chr19	13212223	13215784	13101409	13104970	50488	hg19	N/A	N/A	N/A	Enhatls87736	enhancer	E_526				TGCACGCAGGGGGTAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					LYL1	chr19	13099032	13103161	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2803
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50489	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				AATAAATCAAACACATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50490	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				AATAAATCAAACACATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50491	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				AATAAATCAAACACATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50492	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				AATAAATCAAACACATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50493	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				ACGTACTAGGTGCCTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50494	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				ACGTACTAGGTGCCTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50495	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				ACGTACTAGGTGCCTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50496	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				ACGTACTAGGTGCCTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50497	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				CCTGGAGGCCACATACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50498	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				CCTGGAGGCCACATACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50499	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				CCTGGAGGCCACATACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50500	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				CCTGGAGGCCACATACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50501	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				GGGGAGGATTTCTTCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50502	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				GGGGAGGATTTCTTCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50503	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				GGGGAGGATTTCTTCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50504	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				GGGGAGGATTTCTTCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50505	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				GACAGACAGACGAACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50506	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				GACAGACAGACGAACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50507	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				GACAGACAGACGAACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50508	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				GACAGACAGACGAACGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50509	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				TCTGGGCCCAGGGCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50510	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				TCTGGGCCCAGGGCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50511	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				TCTGGGCCCAGGGCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50512	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				TCTGGGCCCAGGGCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50513	hg19	N/A	enh112595	N/A	Enhatls87791	enhancer	E_528				ACATCAAAAGCTCTGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50514	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				ACATCAAAAGCTCTGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50515	hg19	N/A	N/A	fant56349	Enhatls87791	enhancer	E_528				ACATCAAAAGCTCTGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13731345	13735990	13620531	13625176	50516	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_528				ACATCAAAAGCTCTGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50517	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TCCTAGTATAACATAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50518	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				TCCTAGTATAACATAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50519	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TCCTAGTATAACATAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50520	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				TCCTAGTATAACATAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50521	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ATAAGCTGTCATTATTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50522	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				ATAAGCTGTCATTATTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50523	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ATAAGCTGTCATTATTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50524	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				ATAAGCTGTCATTATTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50525	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ATCAACATAAATAGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50526	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				ATCAACATAAATAGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50527	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ATCAACATAAATAGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50528	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				ATCAACATAAATAGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50529	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GTTTAAAAGATGGTTGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50530	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				GTTTAAAAGATGGTTGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50531	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GTTTAAAAGATGGTTGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50532	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				GTTTAAAAGATGGTTGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50533	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				CTGTGTGCCTATCTTTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50534	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				CTGTGTGCCTATCTTTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50535	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				CTGTGTGCCTATCTTTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50536	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				CTGTGTGCCTATCTTTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50537	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GACTTGCTTCAGTCAATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50538	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				GACTTGCTTCAGTCAATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50539	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GACTTGCTTCAGTCAATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50540	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				GACTTGCTTCAGTCAATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50541	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ACGGAAACAACTGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50542	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				ACGGAAACAACTGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50543	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ACGGAAACAACTGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50544	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				ACGGAAACAACTGTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50545	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ACATGTGTACCAGCTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50546	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				ACATGTGTACCAGCTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50547	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				ACATGTGTACCAGCTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50548	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				ACATGTGTACCAGCTGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50549	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TTTCCTTTGGTAGCCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50550	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				TTTCCTTTGGTAGCCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50551	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TTTCCTTTGGTAGCCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50552	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				TTTCCTTTGGTAGCCAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50553	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GCTCAAAACCAGATGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50554	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				GCTCAAAACCAGATGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50555	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				GCTCAAAACCAGATGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50556	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				GCTCAAAACCAGATGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50557	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TTGGCCAGCTGCCTGCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50558	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				TTGGCCAGCTGCCTGCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50559	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TTGGCCAGCTGCCTGCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50560	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				TTGGCCAGCTGCCTGCTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50561	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TGTGTGCGGGGCTCAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50562	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				TGTGTGCGGGGCTCAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50563	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TGTGTGCGGGGCTCAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50564	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				TGTGTGCGGGGCTCAGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50565	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				CTTGCCTGGGCCAATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50566	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				CTTGCCTGGGCCAATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50567	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				CTTGCCTGGGCCAATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50568	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				CTTGCCTGGGCCAATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50569	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TATGCATTAACAGTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50570	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				TATGCATTAACAGTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50571	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				TATGCATTAACAGTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50572	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				TATGCATTAACAGTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50573	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				AGTTGGGGTCTGAGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50574	hg19	N/A	N/A	fant56350	Enhatls87791	enhancer	E_529				AGTTGGGGTCTGAGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8535				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50575	hg19	N/A	N/A	N/A	Enhatls87791	enhancer	E_529				AGTTGGGGTCTGAGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	8942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81889	chr19	13738570	13746524	13627756	13635710	50576	hg19	N/A	enh81488	N/A	Enhatls87791	enhancer	E_529				AGTTGGGGTCTGAGCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"JUNB,PRKACA"	direct	Highly Significant	NA					CACNA1A	chr19	13206441	13624489	11143				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2859
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50577	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50578	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50579	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50580	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50581	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50582	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50583	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50584	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50585	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50586	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50587	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50588	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50589	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50590	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50591	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50592	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50593	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50594	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50595	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGATACCTAGAGGGCCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50596	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50597	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50598	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50599	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50600	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50601	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50602	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50603	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50604	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50605	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50606	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50607	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50608	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50609	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50610	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50611	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50612	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50613	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50614	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGGCCAAATGGGGCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50615	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50616	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50617	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50618	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50619	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50620	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50621	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50622	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50623	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50624	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50625	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50626	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50627	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50628	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50629	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50630	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50631	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50632	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50633	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGGAAGTGGCGCCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50634	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50635	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50636	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50637	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50638	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50639	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50640	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50641	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50642	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50643	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50644	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50645	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50646	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50647	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50648	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50649	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50650	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50651	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50652	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGGTCTCCTCAGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50653	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50654	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50655	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50656	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50657	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50658	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50659	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50660	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50661	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50662	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50663	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50664	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50665	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50666	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50667	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50668	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50669	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50670	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50671	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTCTCCACCCAAACAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50672	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50673	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50674	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50675	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50676	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50677	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50678	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50679	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50680	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50681	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50682	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50683	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50684	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50685	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50686	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50687	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50688	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50689	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50690	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTATGCAAAAGAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50691	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50692	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50693	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50694	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50695	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50696	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50697	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50698	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50699	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50700	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50701	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50702	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50703	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50704	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50705	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50706	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50707	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50708	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50709	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AAGAGGGTAAGTGATACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50710	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50711	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50712	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50713	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50714	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50715	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50716	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50717	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50718	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50719	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50720	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50721	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50722	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50723	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50724	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50725	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50726	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50727	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50728	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTCACCCCAGCTCACATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50729	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50730	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50731	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50732	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50733	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50734	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50735	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50736	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50737	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50738	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50739	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50740	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50741	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50742	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50743	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50744	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50745	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50746	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50747	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACGTGGGACTTCCTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50748	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50749	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50750	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50751	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50752	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50753	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50754	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50755	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50756	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50757	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50758	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50759	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50760	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50761	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50762	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50763	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50764	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50765	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50766	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TCGCCAGGGCAACAGGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50767	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50768	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50769	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50770	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50771	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50772	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50773	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50774	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50775	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50776	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50777	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50778	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50779	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50780	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50781	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50782	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50783	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50784	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50785	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GAGTTTGTCACGGTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50786	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50787	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50788	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50789	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50790	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50791	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50792	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50793	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50794	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50795	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50796	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50797	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50798	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50799	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50800	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50801	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50802	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50803	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50804	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTTGTCTACCTACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50805	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50806	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50807	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50808	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50809	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50810	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50811	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50812	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50813	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50814	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50815	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50816	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50817	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50818	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50819	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50820	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50821	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50822	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50823	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCAGGTGCCTGAAATCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50824	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50825	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50826	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50827	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50828	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50829	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50830	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50831	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50832	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50833	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50834	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50835	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50836	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50837	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50838	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50839	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50840	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50841	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50842	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTGGTGAGTCATTCCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50843	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50844	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50845	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50846	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50847	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50848	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50849	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50850	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50851	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50852	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50853	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50854	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50855	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50856	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50857	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50858	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50859	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50860	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50861	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GTTAAGGAGAGCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50862	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50863	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50864	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50865	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50866	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50867	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50868	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50869	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50870	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50871	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50872	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50873	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50874	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50875	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50876	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50877	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50878	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50879	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50880	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AACCCCCAGTGACGTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50881	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50882	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50883	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50884	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50885	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50886	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50887	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50888	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50889	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50890	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50891	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50892	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50893	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50894	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50895	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50896	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50897	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50898	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50899	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCAGCCGACGGGTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50900	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50901	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50902	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50903	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50904	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50905	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50906	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50907	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50908	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50909	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50910	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50911	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50912	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50913	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50914	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50915	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50916	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50917	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50918	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCGACTCTGCTGGGACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50919	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50920	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50921	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50922	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50923	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50924	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50925	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50926	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50927	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50928	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50929	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50930	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50931	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50932	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50933	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50934	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50935	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50936	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50937	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				AGAGCCCTCGAGCCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50938	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50939	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50940	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50941	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50942	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50943	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50944	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50945	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50946	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50947	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50948	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50949	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50950	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50951	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50952	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50953	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50954	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50955	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50956	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGGGGCGGCGGGGAACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50957	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50958	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50959	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50960	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50961	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50962	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50963	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50964	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50965	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50966	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50967	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50968	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50969	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50970	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50971	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50972	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50973	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50974	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50975	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCCGCCAGATGTGGGGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50976	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50977	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50978	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50979	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50980	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50981	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50982	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50983	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50984	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50985	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50986	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50987	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50988	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50989	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50990	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50991	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50992	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50993	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50994	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CCTGCCGGCGGCGCAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50995	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50996	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50997	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50998	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	50999	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51000	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51001	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51002	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51003	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51004	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51005	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51006	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51007	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51008	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51009	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51010	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51011	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51012	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51013	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GCGGAAATTGATTCTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51014	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51015	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51016	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51017	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51018	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51019	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51020	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51021	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51022	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51023	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51024	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51025	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51026	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51027	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51028	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51029	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51030	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51031	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51032	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGATTCTCAAACCACCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51033	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51034	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51035	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51036	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51037	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51038	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51039	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51040	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51041	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51042	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51043	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51044	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51045	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51046	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51047	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51048	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51049	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51050	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51051	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACTTGCCACCCACTTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51052	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51053	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51054	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51055	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51056	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51057	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51058	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51059	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51060	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51061	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51062	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51063	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51064	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51065	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51066	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51067	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51068	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51069	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51070	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				TGTGAGCCAGCTTCGGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51071	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51072	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51073	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51074	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51075	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51076	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51077	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51078	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51079	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51080	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51081	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51082	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51083	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51084	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51085	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51086	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51087	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51088	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51089	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GGCTTGAGTCACACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51090	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51091	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51092	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51093	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51094	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51095	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51096	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51097	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51098	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51099	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51100	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51101	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51102	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51103	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51104	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51105	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51106	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51107	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51108	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CTAGAGAGGGCCTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51109	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51110	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51111	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51112	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51113	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51114	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51115	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51116	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51117	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51118	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51119	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51120	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51121	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51122	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51123	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51124	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51125	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51126	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51127	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				GACCCAGGCCGGGCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51128	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51129	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51130	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51131	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51132	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51133	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51134	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51135	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51136	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51137	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51138	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51139	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51140	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51141	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51142	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51143	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51144	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51145	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51146	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				ATAGGAAGCTGGGTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51147	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51148	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51149	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51150	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51151	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51152	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51153	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51154	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51155	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51156	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51157	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51158	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51159	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51160	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51161	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51162	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51163	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51164	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51165	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCAGGGCCCACGCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51166	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51167	hg19	N/A	enh5016	fant56354	Enhatls87815	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51168	hg19	N/A	enh5016	N/A	Enhatls87815	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	1616				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51169	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	2253				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51170	hg19	N/A	enh5016	fant56355	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51171	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	3816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51172	hg19	N/A	enh5016	fant56356	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4477				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51173	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	4963				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51174	hg19	N/A	enh5016	fant56357	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	6431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51175	hg19	N/A	enh5016	N/A	N/A	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	8562				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51176	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	9403				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51177	hg19	N/A	enh5016	fant56358	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11290				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51178	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	11740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51179	hg19	N/A	enh5016	fant56359	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12050				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51180	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	12522				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51181	hg19	N/A	enh5016	fant56360	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51182	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					ZSWIM4	chr19	13795442	13832254	16968				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51183	hg19	N/A	enh5016	fant56361	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	22102				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81913	chr19	13943380	13967098	13832566	13856284	51184	hg19	N/A	enh5016	N/A	Enhatls87816	enhancer	E_530				CGCTTCGAGTCAGGCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					NANOS3	chr19	13877133	13880757	20333				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2883
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51185	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GGGTCCCTCTTGGATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51186	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GGGTCCCTCTTGGATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51187	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GGGTCCCTCTTGGATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51188	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GGGTCCCTCTTGGATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51189	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GGGTCCCTCTTGGATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51190	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				ACTTGTGGCCCGTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51191	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				ACTTGTGGCCCGTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51192	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				ACTTGTGGCCCGTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51193	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				ACTTGTGGCCCGTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51194	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				ACTTGTGGCCCGTTGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51195	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				AAGCTCCTGCGAGCAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51196	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				AAGCTCCTGCGAGCAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51197	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				AAGCTCCTGCGAGCAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51198	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				AAGCTCCTGCGAGCAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51199	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				AAGCTCCTGCGAGCAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51200	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				TCCAGTCCGAGATTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51201	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				TCCAGTCCGAGATTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51202	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				TCCAGTCCGAGATTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51203	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				TCCAGTCCGAGATTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51204	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				TCCAGTCCGAGATTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51205	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				ACAGGTCGTCGTCTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51206	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				ACAGGTCGTCGTCTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51207	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				ACAGGTCGTCGTCTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51208	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				ACAGGTCGTCGTCTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51209	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				ACAGGTCGTCGTCTTTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51210	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCCCTTAGGAAACTGATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51211	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GCCCTTAGGAAACTGATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51212	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCCCTTAGGAAACTGATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51213	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GCCCTTAGGAAACTGATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51214	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GCCCTTAGGAAACTGATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51215	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GGAAATTCAACGTCCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51216	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GGAAATTCAACGTCCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51217	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GGAAATTCAACGTCCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51218	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GGAAATTCAACGTCCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51219	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GGAAATTCAACGTCCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51220	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GAAGTGGTGCCCGTCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51221	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GAAGTGGTGCCCGTCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51222	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GAAGTGGTGCCCGTCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51223	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GAAGTGGTGCCCGTCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51224	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GAAGTGGTGCCCGTCAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51225	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCCTGGAATTCGCCAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51226	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GCCTGGAATTCGCCAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51227	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCCTGGAATTCGCCAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51228	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GCCTGGAATTCGCCAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51229	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GCCTGGAATTCGCCAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51230	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GAGGGGCGCGGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51231	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GAGGGGCGCGGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51232	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GAGGGGCGCGGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51233	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GAGGGGCGCGGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51234	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GAGGGGCGCGGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51235	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				CACCGAGTCCGGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51236	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				CACCGAGTCCGGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51237	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				CACCGAGTCCGGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51238	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				CACCGAGTCCGGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51239	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				CACCGAGTCCGGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51240	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GTTCCAAACTCCAGAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51241	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GTTCCAAACTCCAGAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51242	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GTTCCAAACTCCAGAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51243	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GTTCCAAACTCCAGAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51244	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GTTCCAAACTCCAGAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51245	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				CCGTGAGGATCTGCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51246	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				CCGTGAGGATCTGCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51247	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				CCGTGAGGATCTGCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51248	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				CCGTGAGGATCTGCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51249	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				CCGTGAGGATCTGCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51250	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCTGCGGGCACAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51251	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GCTGCGGGCACAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51252	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GCTGCGGGCACAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51253	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GCTGCGGGCACAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51254	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GCTGCGGGCACAAAATCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51255	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GTGAGAGGCTCAGGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51256	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GTGAGAGGCTCAGGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51257	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GTGAGAGGCTCAGGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51258	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GTGAGAGGCTCAGGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51259	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GTGAGAGGCTCAGGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51260	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GACTTAGTAATGGCTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51261	hg19	N/A	N/A	fant56372	Enhatls87889	enhancer	E_532				GACTTAGTAATGGCTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	1218				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81973	chr19	14190775	14193479	14079963	14082667	51262	hg19	N/A	N/A	N/A	Enhatls87889	enhancer	E_532				GACTTAGTAATGGCTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2943
enhrx-81974	chr19	14190775	14193479	14079963	14082667	51263	hg19	N/A	N/A	N/A	Enhatls87890	enhancer	E_532				GACTTAGTAATGGCTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2944
enhrx-81975	chr19	14190775	14193479	14079963	14082667	51264	hg19	N/A	N/A	N/A	Enhatls87891	enhancer	E_532				GACTTAGTAATGGCTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					C19orf67	chr19	14081623	14085789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2945
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51265	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51266	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51267	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51268	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51269	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51270	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGAGGGATGAGACTTGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51271	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51272	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51273	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51274	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51275	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51276	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCCGTGGCCCACAAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51277	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51278	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51279	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51280	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51281	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51282	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				AGGCTGGACCATACCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51283	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51284	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51285	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51286	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51287	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51288	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				ACAAAGGCCAGTAGACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51289	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51290	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51291	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51292	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51293	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51294	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAAATGGCCATCCTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51295	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51296	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51297	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51298	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51299	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51300	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TTGTGGGGGAGGTCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51301	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51302	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51303	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51304	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51305	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51306	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGGTGACAAAACATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51307	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51308	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51309	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51310	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51311	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51312	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCAGGTCCCATGAACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51313	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51314	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51315	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51316	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51317	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51318	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				GGTATGGGAAGGAGGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51319	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51320	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51321	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51322	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51323	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51324	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CCCAAAGCCGATGTCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51325	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51326	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51327	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51328	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51329	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51330	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTTGCAGCCAGTCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51331	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51332	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51333	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51334	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51335	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51336	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				TCACTGTGACCAGCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51337	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51338	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51339	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51340	hg19	N/A	enh5022	fant56402	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51341	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					DNAJB1	chr19	14514768	14560262	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82052	chr19	14663892	14667766	14553080	14556954	51342	hg19	N/A	enh5022	N/A	Enhatls87989	enhancer	E_537				CTGTGGATCCTGCCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKACA	direct	Highly Significant	NA					TECR	chr19	14529593	14565980	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3022
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51343	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CCTCGAGACATGGGGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51344	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CCTCGAGACATGGGGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51345	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CCTCGAGACATGGGGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51346	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CCTCGAGACATGGGGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51347	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CGCAGACATGTTGATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51348	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CGCAGACATGTTGATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51349	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CGCAGACATGTTGATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51350	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CGCAGACATGTTGATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51351	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				TGAAGAGACGCATTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51352	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				TGAAGAGACGCATTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51353	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				TGAAGAGACGCATTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51354	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				TGAAGAGACGCATTCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51355	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CGTCCCAGGTCACACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51356	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CGTCCCAGGTCACACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51357	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CGTCCCAGGTCACACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51358	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CGTCCCAGGTCACACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51359	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CCCGGTGGCTGAGTGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51360	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				CCCGGTGGCTGAGTGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51361	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CCCGGTGGCTGAGTGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51362	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				CCCGGTGGCTGAGTGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51363	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				GCTGGACTGGTACCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82569	chr19	17412318	17424871	17301509	17314062	51364	hg19	N/A	enh5040	N/A	N/A	enhancer	E_538				GCTGGACTGGTACCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MRPL34	chr19	17292608	17306843	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3539
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51365	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				GCTGGACTGGTACCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					ABHD8	chr19	17292130	17310236	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82570	chr19	17412318	17424871	17301509	17314062	51366	hg19	N/A	N/A	N/A	Enhatls88543	enhancer	E_538				GCTGGACTGGTACCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					DDA1	chr19	17309562	17323298	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3540
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51367	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				GCTATTATCTCAGCGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51368	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				GCTATTATCTCAGCGCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51369	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				CATTTTCTCATCCAAGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51370	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				CATTTTCTCATCCAAGCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51371	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				TCTTCTGGGATGGTTAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51372	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				TCTTCTGGGATGGTTAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51373	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				TCTGCCAAGACAGAGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51374	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				TCTGCCAAGACAGAGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51375	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				TTTCCGGGATACGGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51376	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				TTTCCGGGATACGGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51377	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				ACGGATGAGTCACAAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51378	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				ACGGATGAGTCACAAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51379	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				GATGGGCTGGGAGGGAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51380	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				GATGGGCTGGGAGGGAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51381	hg19	N/A	enh44631	N/A	Enhatls88556	enhancer	E_539				GAAAGAAAGAAAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	331				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82583	chr19	17457269	17462985	17346460	17352176	51382	hg19	N/A	N/A	N/A	Enhatls88556	enhancer	E_539				GAAAGAAAGAAAGAAATCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					PLVAP	chr19	17351449	17377342	94				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3553
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51383	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				TGACTATTGCAGAGTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51384	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				CAGACTCTAAAGGGGAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51385	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				TTCCTATGCTAATAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51386	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				CATGAGGCACCTACAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51387	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				GCCCAAGGGCTTTTAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51388	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				ACTATGACCTGAAGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51389	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				ACAGTTGCGTGGTGGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51390	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				AGTGCCTCTGTCCCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51391	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				GTGTGAGCAACAGGTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51392	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				GTCTCTGTCTTGGCACCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51393	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				CCATGTGGCCAAGAGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51394	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				GCTGGGCATGACCGCTGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51395	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				ATGGCAGACCTAACAGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51396	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				TTTCAGCAGGGCCAGACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82591	chr19	17515810	17518202	17405001	17407393	51397	hg19	N/A	N/A	N/A	Enhatls88564	enhancer	E_540				CATTAAAGCCACTTAGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					BST2	chr19	17402938	17405630	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3561
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51398	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CGTGCAGGATCTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51399	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CGTGCAGGATCTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51400	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CGTGCAGGATCTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51401	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CGTGCAGGATCTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51402	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CGTGCAGGATCTCTACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51403	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				TGTGTTTCCTAAAAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51404	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				TGTGTTTCCTAAAAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51405	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				TGTGTTTCCTAAAAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51406	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				TGTGTTTCCTAAAAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51407	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				TGTGTTTCCTAAAAGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51408	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GGTGCTAGAACGGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51409	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GGTGCTAGAACGGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51410	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GGTGCTAGAACGGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51411	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GGTGCTAGAACGGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51412	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GGTGCTAGAACGGCCCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51413	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CAGAAGCCACGACCATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51414	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CAGAAGCCACGACCATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51415	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CAGAAGCCACGACCATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51416	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CAGAAGCCACGACCATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51417	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CAGAAGCCACGACCATAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51418	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CTCAGGTTCTATCCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51419	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CTCAGGTTCTATCCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51420	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CTCAGGTTCTATCCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51421	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CTCAGGTTCTATCCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51422	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CTCAGGTTCTATCCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51423	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GGAGGGCTCTAGTTTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51424	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GGAGGGCTCTAGTTTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51425	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GGAGGGCTCTAGTTTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51426	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GGAGGGCTCTAGTTTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51427	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GGAGGGCTCTAGTTTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51428	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GGAGGCATATGTCTAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51429	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GGAGGCATATGTCTAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51430	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GGAGGCATATGTCTAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51431	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GGAGGCATATGTCTAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51432	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GGAGGCATATGTCTAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51433	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				AGAAGCATAACCTAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51434	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				AGAAGCATAACCTAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51435	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				AGAAGCATAACCTAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51436	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				AGAAGCATAACCTAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51437	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				AGAAGCATAACCTAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51438	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CAGGACGTGAAGGGTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51439	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CAGGACGTGAAGGGTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51440	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CAGGACGTGAAGGGTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51441	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CAGGACGTGAAGGGTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51442	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CAGGACGTGAAGGGTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51443	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GGACTGTTGTAAGATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51444	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GGACTGTTGTAAGATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51445	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GGACTGTTGTAAGATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51446	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GGACTGTTGTAAGATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51447	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GGACTGTTGTAAGATTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51448	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				ATAGAGCGGACCCAGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51449	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				ATAGAGCGGACCCAGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51450	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				ATAGAGCGGACCCAGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51451	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				ATAGAGCGGACCCAGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51452	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				ATAGAGCGGACCCAGGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51453	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GCTAACTAGGAACCAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51454	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GCTAACTAGGAACCAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51455	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GCTAACTAGGAACCAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51456	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GCTAACTAGGAACCAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51457	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GCTAACTAGGAACCAGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51458	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				AGTTGACCAATCCCAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51459	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				AGTTGACCAATCCCAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51460	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				AGTTGACCAATCCCAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51461	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				AGTTGACCAATCCCAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51462	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				AGTTGACCAATCCCAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51463	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GGCGCGGCTCGCTGTAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51464	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GGCGCGGCTCGCTGTAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51465	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GGCGCGGCTCGCTGTAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51466	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GGCGCGGCTCGCTGTAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51467	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GGCGCGGCTCGCTGTAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51468	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CAGCGCCAGCGAGACCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51469	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CAGCGCCAGCGAGACCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51470	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CAGCGCCAGCGAGACCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51471	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CAGCGCCAGCGAGACCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51472	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CAGCGCCAGCGAGACCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51473	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GCGGCGCTCGGCGTGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51474	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GCGGCGCTCGGCGTGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51475	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GCGGCGCTCGGCGTGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51476	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GCGGCGCTCGGCGTGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51477	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GCGGCGCTCGGCGTGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51478	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GTGTTGCCGGGATCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51479	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GTGTTGCCGGGATCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51480	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GTGTTGCCGGGATCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51481	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GTGTTGCCGGGATCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51482	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GTGTTGCCGGGATCCGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51483	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				ACTGCACTCCAGCCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51484	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				ACTGCACTCCAGCCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51485	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				ACTGCACTCCAGCCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51486	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				ACTGCACTCCAGCCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51487	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				ACTGCACTCCAGCCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51488	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				TGTTCTCTCACGTGTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51489	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				TGTTCTCTCACGTGTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51490	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				TGTTCTCTCACGTGTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51491	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				TGTTCTCTCACGTGTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51492	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				TGTTCTCTCACGTGTTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51493	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				TGCCCAGAAACACACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51494	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				TGCCCAGAAACACACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51495	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				TGCCCAGAAACACACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51496	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				TGCCCAGAAACACACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51497	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				TGCCCAGAAACACACAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51498	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CATGTTAGGAGAGTCAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51499	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CATGTTAGGAGAGTCAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51500	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CATGTTAGGAGAGTCAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51501	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CATGTTAGGAGAGTCAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51502	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CATGTTAGGAGAGTCAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51503	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				CAGGGCGGAAGAAATCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51504	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				CAGGGCGGAAGAAATCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51505	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				CAGGGCGGAAGAAATCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51506	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				CAGGGCGGAAGAAATCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51507	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				CAGGGCGGAAGAAATCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51508	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				ACAGTGGGCTCATTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51509	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				ACAGTGGGCTCATTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51510	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				ACAGTGGGCTCATTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51511	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				ACAGTGGGCTCATTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51512	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				ACAGTGGGCTCATTGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51513	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				TACAGGAATCCACTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51514	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				TACAGGAATCCACTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51515	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				TACAGGAATCCACTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51516	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				TACAGGAATCCACTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51517	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				TACAGGAATCCACTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51518	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GAGCTAGATGTGGGAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51519	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GAGCTAGATGTGGGAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51520	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GAGCTAGATGTGGGAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51521	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GAGCTAGATGTGGGAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51522	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GAGCTAGATGTGGGAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82604	chr19	17576501	17591322	17465692	17480513	51523	hg19	N/A	N/A	fant56503	N/A	enhancer	E_541				GACGGGCACCCTACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	2385				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3574
enhrx-82605	chr19	17576501	17591322	17465692	17480513	51524	hg19	N/A	N/A	fant56504	N/A	enhancer	E_541				GACGGGCACCCTACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3575
enhrx-82606	chr19	17576501	17591322	17465692	17480513	51525	hg19	N/A	N/A	fant56505	N/A	enhancer	E_541				GACGGGCACCCTACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	428				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3576
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51526	hg19	N/A	N/A	N/A	Enhatls88577	enhancer	E_541				GACGGGCACCCTACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82607	chr19	17576501	17591322	17465692	17480513	51527	hg19	N/A	enh17968	N/A	Enhatls88577	enhancer	E_541				GACGGGCACCCTACTGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					SLC27A1	chr19	17470488	17506168	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3577
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51528	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				AGAAATCTATCTTGTAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51529	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				AGAAATCTATCTTGTAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51530	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				AGAAATCTATCTTGTAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51531	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				AGAAATCTATCTTGTAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51532	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				AGAGAGCTGGGAGCATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51533	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				AGAGAGCTGGGAGCATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51534	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				AGAGAGCTGGGAGCATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51535	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				AGAGAGCTGGGAGCATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51536	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				CATGTGATGTGAGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51537	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CATGTGATGTGAGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51538	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				CATGTGATGTGAGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51539	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CATGTGATGTGAGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51540	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				GATGCGGGCGTTAAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51541	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GATGCGGGCGTTAAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51542	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				GATGCGGGCGTTAAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51543	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GATGCGGGCGTTAAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51544	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				GTGGTCGACAAAAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51545	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GTGGTCGACAAAAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51546	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				GTGGTCGACAAAAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51547	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GTGGTCGACAAAAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51548	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				CCGGGGCGGCCCGAAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51549	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CCGGGGCGGCCCGAAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51550	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				CCGGGGCGGCCCGAAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51551	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CCGGGGCGGCCCGAAGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51552	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				GCAGCGAGTTCGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51553	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GCAGCGAGTTCGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51554	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				GCAGCGAGTTCGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51555	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				GCAGCGAGTTCGGGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82673	chr19	17828502	17833480	17717693	17722671	51556	hg19	N/A	N/A	N/A	Enhatls88650	enhancer	E_542				CCCGGGCCCAGACGCGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3643
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51557	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CCCGGGCCCAGACGCGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51558	hg19	N/A	N/A	fant56511	Enhatls88651	enhancer	E_542				CCCGGGCCCAGACGCGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82674	chr19	17828502	17833480	17717693	17722671	51559	hg19	N/A	N/A	N/A	Enhatls88651	enhancer	E_542				CCCGGGCCCAGACGCGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					MAP1S	chr19	17719241	17734513	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3644
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51560	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51561	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51562	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51563	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51564	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51565	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				AATGTATTTTCTTTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51566	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51567	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51568	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51569	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51570	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51571	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				CTATGGCCAGGTGTGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51572	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51573	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51574	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51575	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51576	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51577	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				TAATGTTACTTGGTAAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51578	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51579	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51580	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51581	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51582	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51583	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				TTTGGTCTCGTCTTGTTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51584	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51585	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51586	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51587	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51588	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51589	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				ATCATGTCCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51590	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51591	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51592	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51593	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51594	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51595	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				GACGGGGGCAGCACTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51596	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51597	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51598	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51599	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51600	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51601	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				CAGGGACTTCCAGGCAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51602	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51603	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51604	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51605	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51606	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51607	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				TCACCGCCCTCACTTTATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51608	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51609	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51610	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51611	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51612	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51613	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				TGGAGATGAGGGTATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51614	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51615	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51616	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51617	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51618	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51619	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				GTTCCCAGGCTGCTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51620	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51621	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51622	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51623	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51624	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51625	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				AGGCCAATCCCATTATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51626	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51627	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51628	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51629	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51630	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51631	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				CTGCACCTATTCACCTACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51632	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51633	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51634	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51635	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51636	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51637	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				CAGGGGGTGGGGGAATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51638	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51639	hg19	N/A	enh108720	N/A	Enhatls88706	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51640	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51641	hg19	N/A	enh108720	N/A	Enhatls88707	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51642	hg19	N/A	enh108720	N/A	N/A	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82721	chr19	17968987	17976966	17858178	17866157	51643	hg19	N/A	enh108720	N/A	Enhatls88708	enhancer	E_545				GGGTGGATTGAGTGGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					RPL18A	chr19	17859909	17864153	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3691
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51644	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51645	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51646	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51647	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51648	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51649	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51650	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51651	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51652	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51653	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51654	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51655	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51656	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51657	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51658	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51659	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CCACCCCCTAAGAGCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51660	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51661	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51662	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51663	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51664	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51665	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51666	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51667	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51668	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51669	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51670	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51671	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51672	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51673	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51674	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51675	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GAGGTTGGGGAACAGGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51676	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51677	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51678	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51679	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51680	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51681	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51682	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51683	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51684	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51685	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51686	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51687	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51688	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51689	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51690	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51691	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CTCCCCCTCCATGTACCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51692	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51693	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51694	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51695	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51696	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51697	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51698	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51699	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51700	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51701	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51702	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51703	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51704	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51705	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51706	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51707	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				TTGTTTGTATCCCCAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51708	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51709	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51710	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51711	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51712	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51713	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51714	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51715	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51716	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51717	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51718	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51719	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51720	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51721	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51722	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51723	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GACCAAAAAGGGGGTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51724	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51725	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51726	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51727	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51728	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51729	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51730	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51731	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51732	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51733	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51734	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51735	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51736	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51737	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51738	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51739	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				ACTGCGGGCTCCTTGGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51740	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51741	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51742	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51743	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51744	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51745	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51746	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51747	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51748	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51749	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51750	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51751	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51752	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51753	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51754	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51755	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GACTTCCCCTTATAGCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51756	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51757	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51758	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51759	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51760	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51761	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51762	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51763	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51764	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51765	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51766	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51767	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51768	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51769	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51770	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51771	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GTCAGCCTTGGCCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51772	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51773	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51774	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51775	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51776	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51777	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51778	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51779	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51780	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51781	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51782	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51783	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51784	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51785	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51786	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51787	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CTTCTGGGCCAGGCTGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51788	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51789	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51790	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51791	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51792	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51793	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51794	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51795	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51796	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51797	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51798	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51799	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51800	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51801	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51802	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51803	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GCCGGGACAAGAACCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51804	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51805	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51806	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51807	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51808	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51809	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51810	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51811	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51812	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51813	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51814	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51815	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51816	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51817	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51818	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51819	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CATGGCAGATGGCAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51820	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51821	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51822	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51823	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51824	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51825	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51826	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51827	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51828	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51829	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51830	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51831	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51832	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51833	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51834	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51835	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GCTTGAACCCGGGGAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51836	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51837	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51838	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51839	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51840	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51841	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51842	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51843	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51844	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51845	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51846	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51847	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51848	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51849	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51850	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51851	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CACAAGTGATCCGCCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51852	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51853	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51854	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51855	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51856	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51857	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51858	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51859	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51860	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51861	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51862	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51863	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51864	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51865	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51866	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51867	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				TGTTCTGATGAAACATCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51868	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51869	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51870	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51871	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51872	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51873	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51874	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51875	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51876	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51877	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51878	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51879	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51880	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51881	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51882	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51883	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				AAGGTGCTGGCCTAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51884	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51885	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51886	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51887	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51888	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51889	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51890	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51891	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51892	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51893	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51894	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51895	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51896	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51897	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51898	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51899	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GCGCTCAGCTGCATGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51900	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51901	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51902	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51903	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51904	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51905	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51906	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51907	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51908	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51909	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51910	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51911	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51912	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51913	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51914	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51915	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GTCCTGACTGCACCAGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51916	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51917	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51918	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51919	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51920	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51921	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51922	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51923	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51924	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51925	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51926	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51927	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51928	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51929	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51930	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51931	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GAGGCGAGCAGGCCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51932	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51933	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51934	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51935	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51936	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51937	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51938	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51939	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51940	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51941	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51942	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51943	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51944	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51945	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51946	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51947	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GGGGCGCCCCGGGGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51948	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51949	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51950	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51951	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51952	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51953	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51954	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51955	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51956	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51957	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51958	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51959	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51960	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51961	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51962	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51963	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				TACGGCGATGAGGCGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51964	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51965	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51966	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51967	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51968	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51969	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51970	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51971	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51972	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51973	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51974	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51975	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51976	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51977	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51978	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51979	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GAGTGGCCGCGGCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51980	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51981	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51982	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51983	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51984	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51985	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51986	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51987	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51988	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51989	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51990	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51991	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51992	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51993	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51994	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51995	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GCGACGTCACCCGCACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	51996	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	51997	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	51998	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	51999	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52000	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52001	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52002	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52003	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52004	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52005	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52006	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52007	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52008	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52009	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52010	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52011	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GCGTTTACCGCGCGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52012	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52013	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52014	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52015	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52016	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52017	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52018	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52019	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52020	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52021	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52022	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52023	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52024	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52025	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52026	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52027	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CTTGTGGGTTGACGTCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52028	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52029	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52030	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52031	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52032	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52033	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52034	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52035	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52036	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52037	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52038	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52039	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52040	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52041	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52042	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52043	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CCGGGTGGCGTGATGGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52044	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52045	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52046	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52047	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52048	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52049	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52050	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52051	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52052	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52053	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52054	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52055	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52056	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52057	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52058	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52059	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CGGTGCCGGCCTCCGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52060	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52061	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52062	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52063	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52064	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52065	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52066	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52067	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52068	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52069	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52070	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52071	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52072	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52073	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52074	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52075	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CCCTGGCGGCACAGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52076	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52077	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52078	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52079	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52080	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52081	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52082	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52083	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52084	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52085	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52086	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52087	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52088	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52089	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52090	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52091	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				CTGTGTCCGGGGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52092	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52093	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52094	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52095	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52096	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52097	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52098	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52099	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52100	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52101	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52102	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52103	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52104	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52105	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52106	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52107	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				ATTGCTCAGGAAGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52108	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52109	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52110	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52111	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52112	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52113	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52114	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52115	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52116	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52117	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52118	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52119	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52120	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52121	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52122	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52123	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				ACTGAGTGCGTTCTAGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52124	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52125	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52126	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52127	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52128	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52129	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52130	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52131	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52132	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52133	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52134	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52135	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52136	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52137	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52138	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52139	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				GTTAGCTAGGAGTCACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82833	chr19	18384132	18405402	18273322	18294592	52140	hg19	N/A	N/A	N/A	Enhatls88827	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3803
enhrx-82834	chr19	18384132	18405402	18273322	18294592	52141	hg19	N/A	N/A	N/A	Enhatls88828	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					IQCN	chr19	18257097	18274500	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3804
enhrx-82835	chr19	18384132	18405402	18273322	18294592	52142	hg19	N/A	enh5047	N/A	N/A	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	29				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3805
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52143	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	1534				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52144	hg19	N/A	enh5048	fant56539	N/A	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3271				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52145	hg19	N/A	enh5048	N/A	N/A	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	3419				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52146	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	5039				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52147	hg19	N/A	enh5048	fant56540	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6371				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52148	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	6546				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52149	hg19	N/A	enh5048	fant56541	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	8578				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52150	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52151	hg19	N/A	enh5048	fant56542	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	9917				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52152	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11133				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52153	hg19	N/A	enh5048	fant56543	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					JUND	chr19	18279693	18281622	11668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52154	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11720				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18384132	18405402	18273322	18294592	52155	hg19	N/A	enh5048	fant56544	Enhatls88829	enhancer	E_546				AACGTGGGCGGCGGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					LSM4	chr19	18306235	18323112	11194				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52156	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GATGGGGGAGGAGAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52157	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				GATGGGGGAGGAGAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52158	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GATGGGGGAGGAGAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52159	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				GATGGGGGAGGAGAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52160	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				GATGGGGGAGGAGAAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52161	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				CTTGGGCAGTGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52162	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				CTTGGGCAGTGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52163	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				CTTGGGCAGTGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52164	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				CTTGGGCAGTGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52165	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				CTTGGGCAGTGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52166	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GGGTGTTTGGCTCCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52167	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				GGGTGTTTGGCTCCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52168	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GGGTGTTTGGCTCCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52169	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				GGGTGTTTGGCTCCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52170	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				GGGTGTTTGGCTCCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52171	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				CTGTGCTGTGACTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52172	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				CTGTGCTGTGACTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52173	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				CTGTGCTGTGACTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52174	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				CTGTGCTGTGACTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52175	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				CTGTGCTGTGACTCAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52176	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GGAGGGCACAGACCATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52177	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				GGAGGGCACAGACCATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52178	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				GGAGGGCACAGACCATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52179	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				GGAGGGCACAGACCATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52180	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				GGAGGGCACAGACCATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52181	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				TTGGTTTCTTTTCTTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52182	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				TTGGTTTCTTTTCTTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52183	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				TTGGTTTCTTTTCTTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52184	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				TTGGTTTCTTTTCTTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52185	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				TTGGTTTCTTTTCTTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52186	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				AGTTGGCTGCCCCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52187	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				AGTTGGCTGCCCCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52188	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				AGTTGGCTGCCCCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52189	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				AGTTGGCTGCCCCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52190	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				AGTTGGCTGCCCCTAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52191	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				AGGTGCTGGGGCTAATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	2015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52192	hg19	N/A	enh5048	fant56545	Enhatls88829	enhancer	E_547				AGGTGCTGGGGCTAATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	930				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52193	hg19	N/A	enh5048	N/A	Enhatls88829	enhancer	E_547				AGGTGCTGGGGCTAATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	337				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82836	chr19	18406782	18420656	18295972	18309846	52194	hg19	N/A	N/A	N/A	Enhatls88829	enhancer	E_547				AGGTGCTGGGGCTAATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3806
enhrx-82837	chr19	18406782	18420656	18295972	18309846	52195	hg19	N/A	N/A	N/A	Enhatls88830	enhancer	E_547				AGGTGCTGGGGCTAATCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					LSM4	chr19	18306235	18323112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3807
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52196	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52197	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52198	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52199	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52200	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52201	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				AGTGGCATGGTCATAGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52202	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52203	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52204	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52205	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52206	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52207	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CAAGAGTGTTAAGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52208	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52209	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52210	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52211	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52212	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52213	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CGGTGTTGAGATACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52214	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52215	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52216	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52217	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52218	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52219	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				TCAAGGAAAAACACGATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52220	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52221	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52222	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52223	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52224	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52225	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				TCCACGGACCCCCTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52226	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52227	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52228	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52229	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52230	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52231	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CATGATCACCGAGACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52232	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52233	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52234	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52235	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52236	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52237	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CTTGGGCCTGGGCTCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52238	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52239	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52240	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52241	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52242	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52243	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				GCGTCTTTCTGCGGGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52244	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52245	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52246	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52247	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52248	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52249	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CCACTCACTCCTCCAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52250	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52251	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52252	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52253	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52254	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52255	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				GTGTTCTCGGCGGGCGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52256	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52257	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52258	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52259	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52260	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52261	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CGGGTAGTGGGGACGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52262	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52263	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52264	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52265	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52266	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52267	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				GGACGCTTCCTGACTCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52268	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52269	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52270	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52271	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52272	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52273	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				AGGTGGTTGGCGCCGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52274	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52275	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52276	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52277	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52278	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52279	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CACCGCCAGTACCTGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52280	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52281	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52282	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52283	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52284	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52285	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				CAGCACCTCCCGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52286	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52287	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52288	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52289	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52290	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52291	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				GCTCCTGCAGGCTGCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52292	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52293	hg19	N/A	enh5053	N/A	Enhatls88897	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52294	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52295	hg19	N/A	enh5053	N/A	Enhatls88898	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52296	hg19	N/A	enh5053	N/A	N/A	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82878	chr19	18697684	18700959	18586874	18590149	52297	hg19	N/A	enh5053	N/A	Enhatls88899	enhancer	E_548				AGGGTCCTAGAGACACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					REX1BD	chr19	18588795	18592337	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3848
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52298	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GTGGGGTAAACTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52299	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GTGGGGTAAACTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52300	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GTGGGGTAAACTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52301	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				TGGTGTTGCCAGGGCAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52302	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				TGGTGTTGCCAGGGCAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52303	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				TGGTGTTGCCAGGGCAGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52304	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CCGGGCCAGGCCTGTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52305	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				CCGGGCCAGGCCTGTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52306	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CCGGGCCAGGCCTGTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52307	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				TCTTGAGACGGCCCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52308	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				TCTTGAGACGGCCCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52309	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				TCTTGAGACGGCCCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52310	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGCCGTCTGGAGACTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52311	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GGCCGTCTGGAGACTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52312	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGCCGTCTGGAGACTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52313	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGTCCTTCCCCTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52314	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GGTCCTTCCCCTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52315	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGTCCTTCCCCTCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52316	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CGGAGAAGCGAGACGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52317	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				CGGAGAAGCGAGACGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52318	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CGGAGAAGCGAGACGCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52319	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				AGCCCCTCCTGGGGAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52320	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				AGCCCCTCCTGGGGAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52321	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				AGCCCCTCCTGGGGAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52322	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GCGGCAGTGAGGGTGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52323	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GCGGCAGTGAGGGTGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52324	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GCGGCAGTGAGGGTGACGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52325	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GAACGCGTCAGGCATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52326	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GAACGCGTCAGGCATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52327	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GAACGCGTCAGGCATCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	indirect	Non Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52328	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CACGCTGGACCAAAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52329	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				CACGCTGGACCAAAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52330	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				CACGCTGGACCAAAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52331	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGGTGTCCTAAATTCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52332	hg19	N/A	enh48176	fant56578	Enhatls88919	enhancer	E_549				GGGTGTCCTAAATTCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82898	chr19	18769806	18774395	18658996	18663585	52333	hg19	N/A	enh48176	N/A	Enhatls88919	enhancer	E_549				GGGTGTCCTAAATTCCAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					KLHL26	chr19	18637024	18671721	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3868
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52334	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GGCACCCTCCATTTTACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52335	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				CCAACTGGAGAGACTGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52336	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GCTAATTGGGGACGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52337	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GCTTTCAACCGCCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52338	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				CGCGTGCGCGAGCCCGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52339	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				AGGGGAGCTGAGGCGCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52340	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				TCTCGGTCCGGCTGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52341	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				CCTAGGCCTCAGCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52342	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				ACCATGAGCGTGGAGGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52343	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GGGGGCGTCTGCGTCTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52344	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GGCGGCGCGGGAGGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52345	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GGCGGGACAGCTCGACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52346	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GGGGGACTCCGGCCAAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52347	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GAAGGAACTCAGCCAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52348	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				CTCGGTCCCGAACGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-82934	chr19	18941919	18945101	18831110	18834292	52349	hg19	N/A	N/A	N/A	Enhatls88956	enhancer	E_553				GTCAGGGGGCAGGTTACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R2	direct	Highly Significant	NA					UPF1	chr19	18831958	18868230	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3904
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52350	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GTAGGGCGCTCCCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52351	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GTAGGGCGCTCCCCCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52352	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				ACACGGCACTCTGCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52353	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				ACACGGCACTCTGCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52354	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GAGCGAGCTTCATCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52355	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GAGCGAGCTTCATCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52356	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				CTTGGAAATGGACCACTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52357	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				CTTGGAAATGGACCACTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52358	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GGAACATGCCGGGAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52359	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GGAACATGCCGGGAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52360	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				AATCCATCCTCTTTCTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52361	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				AATCCATCCTCTTTCTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52362	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				ACGTCAGACCAATGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52363	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				ACGTCAGACCAATGGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52364	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				TGGTTTCTAGATTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52365	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				TGGTTTCTAGATTAGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52366	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				CGGCAGATGACACCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52367	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				CGGCAGATGACACCCATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52368	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GACATTGGCAAGGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52369	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GACATTGGCAAGGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52370	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GCTGCCATATACTGTTCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52371	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GCTGCCATATACTGTTCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52372	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				GCATGTTATAACTTCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52373	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				GCATGTTATAACTTCCCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84376	chr19	39034267	39036823	38543627	38546183	52374	hg19	N/A	N/A	N/A	Enhatls90437	enhancer	E_555				AGTCAGATGACAACGAATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5346
enhrx-84377	chr19	39034267	39036823	38543627	38546183	52375	hg19	N/A	N/A	N/A	Enhatls90438	enhancer	E_555				AGTCAGATGACAACGAATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					RYR1	chr19	38433690	38595273	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5347
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52376	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52377	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52378	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52379	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52380	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52381	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52382	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52383	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				AAGGCAAGTCAAGTATAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52384	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52385	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52386	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52387	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52388	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52389	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52390	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52391	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GCGAGACCTGCCATGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52392	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52393	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52394	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52395	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52396	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52397	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52398	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52399	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				AGGGAAACGAGTATACCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52400	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52401	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52402	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52403	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52404	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52405	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52406	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52407	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GGAACACCCCAGCCCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52408	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52409	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52410	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52411	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52412	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52413	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52414	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52415	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GCACATGACTCACCACCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52416	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52417	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52418	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52419	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52420	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52421	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52422	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52423	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				TCTGGTGTGATCTTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52424	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52425	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52426	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52427	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52428	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52429	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52430	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52431	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GATGAGCCTTGCTCTCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52432	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52433	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52434	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52435	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52436	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52437	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52438	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52439	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				TGAGCCTGGGAGGGAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52440	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52441	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52442	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52443	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52444	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52445	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52446	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52447	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GTAAGAAGAATAGCTAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52448	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52449	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52450	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52451	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52452	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52453	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52454	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52455	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GTGAACCGTGTATGATTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52456	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52457	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52458	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52459	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52460	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52461	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52462	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52463	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				TTATGAGGTGAAGTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52464	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52465	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52466	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52467	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52468	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52469	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52470	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52471	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GGAAGCCTCCACATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52472	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52473	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52474	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52475	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52476	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52477	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52478	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52479	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CGGAGGTGAGCAGCATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52480	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52481	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52482	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52483	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52484	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52485	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52486	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52487	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CATATGATGTCACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52488	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52489	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52490	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52491	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52492	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52493	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52494	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52495	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				AATCATGGAGCTCAAAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52496	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52497	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52498	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52499	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52500	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52501	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52502	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52503	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				TTTTGCAGATGTGGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52504	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52505	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52506	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52507	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52508	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52509	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52510	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52511	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GGCTCACAGCTACTCAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52512	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52513	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52514	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52515	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52516	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52517	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52518	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52519	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GGGTAAAGTAAACCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52520	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52521	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52522	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52523	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52524	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52525	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52526	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52527	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				GTAAAAATAACGTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52528	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52529	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52530	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52531	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52532	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52533	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52534	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52535	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				AATGCTCCAAGCATTCTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52536	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52537	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52538	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52539	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52540	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52541	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52542	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52543	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CAAGTAAAACGTGTAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52544	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52545	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52546	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52547	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52548	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52549	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52550	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52551	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				TTTTAGATATTAGGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52552	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52553	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52554	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52555	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52556	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52557	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52558	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52559	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CTTTGTGACTGGGTAACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52560	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52561	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52562	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52563	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52564	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52565	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52566	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52567	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CTGTGCATAGCCACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52568	hg19	N/A	enh86323	N/A	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17622				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52569	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	17123				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52570	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10664				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52571	hg19	N/A	enh32939	fant56957	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	10440				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52572	hg19	N/A	enh32939	N/A	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	7686				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84526	chr19	39551927	39576748	39061287	39086108	52573	hg19	N/A	N/A	N/A	Enhatls90609	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	5068				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5496
enhrx-84527	chr19	39551927	39576748	39061287	39086108	52574	hg19	N/A	N/A	N/A	Enhatls90610	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5497
enhrx-84528	chr19	39551927	39576748	39061287	39086108	52575	hg19	N/A	N/A	N/A	Enhatls90611	enhancer	E_561				CTCAAGGAACTAACAAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RASGRP4,SAMD4B,ACTN4"	direct	Highly Significant	NA					ACP7	chr19	39084367	39111493	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5498
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52576	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				CATCTGGAGTCTTGGATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52577	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CATCTGGAGTCTTGGATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52578	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				CATCTGGAGTCTTGGATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52579	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CATCTGGAGTCTTGGATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52580	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				TATCCAAAATCCCTATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52581	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TATCCAAAATCCCTATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52582	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				TATCCAAAATCCCTATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52583	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TATCCAAAATCCCTATTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52584	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				TCGTGAGTCGAAGAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52585	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TCGTGAGTCGAAGAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52586	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				TCGTGAGTCGAAGAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52587	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TCGTGAGTCGAAGAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52588	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				CACGGGTTCCAGTCTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52589	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CACGGGTTCCAGTCTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52590	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				CACGGGTTCCAGTCTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52591	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CACGGGTTCCAGTCTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52592	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				GGTGCCAGGCCAGAATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52593	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GGTGCCAGGCCAGAATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52594	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				GGTGCCAGGCCAGAATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52595	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GGTGCCAGGCCAGAATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52596	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				CATGAAGCCAGGTCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52597	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CATGAAGCCAGGTCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52598	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				CATGAAGCCAGGTCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52599	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				CATGAAGCCAGGTCAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52600	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				TGGAAAAGAGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52601	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TGGAAAAGAGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52602	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				TGGAAAAGAGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52603	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				TGGAAAAGAGCGCAGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52604	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				GCAGCGGGTTGCGTGTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52605	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GCAGCGGGTTGCGTGTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52606	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				GCAGCGGGTTGCGTGTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52607	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GCAGCGGGTTGCGTGTCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52608	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				GCTATGAGCCCTGATTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52609	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GCTATGAGCCCTGATTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52610	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				GCTATGAGCCCTGATTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52611	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				GCTATGAGCCCTGATTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52612	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				AAGCCTTTTTGGGTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52613	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				AAGCCTTTTTGGGTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52614	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				AAGCCTTTTTGGGTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52615	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				AAGCCTTTTTGGGTGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52616	hg19	N/A	enh87107	N/A	Enhatls90785	enhancer	E_563				AACAGCACCTGGTACACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52617	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				AACAGCACCTGGTACACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52618	hg19	N/A	N/A	fant56983	Enhatls90785	enhancer	E_563				AACAGCACCTGGTACACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84687	chr19	40332335	40337638	39841695	39846998	52619	hg19	N/A	N/A	N/A	Enhatls90785	enhancer	E_563				AACAGCACCTGGTACACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					FBL	chr19	39834457	39846379	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5657
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52620	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				TCCTATTTCGTGTGAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52621	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				TCCTATTTCGTGTGAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52622	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				ACAGAGCTCTGAGGACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52623	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				ACAGAGCTCTGAGGACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52624	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				GAGGAATGGCCCCAGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52625	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				GAGGAATGGCCCCAGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52626	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				GCTGTGAAGCGGAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52627	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				GCTGTGAAGCGGAAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52628	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				TGTGAGATCATGAGTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52629	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				TGTGAGATCATGAGTGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52630	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				CGCTCAGAGTAGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52631	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				CGCTCAGAGTAGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52632	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				CGGGAGATCTCTGCGGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52633	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				CGGGAGATCTCTGCGGATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52634	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				CCGGGGTCGACGACATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52635	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				CCGGGGTCGACGACATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52636	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				ATCACAGCTCAAGGCTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52637	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				ATCACAGCTCAAGGCTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52638	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				ACTAGGCTCGGCTCCCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52639	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				ACTAGGCTCGGCTCCCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52640	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				GCAACAACCTGTGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52641	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				GCAACAACCTGTGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52642	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				ATTATACTGACGCTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52643	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				ATTATACTGACGCTCCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84747	chr19	40595222	40597598	40089315	40091691	52644	hg19	N/A	N/A	N/A	Enhatls90851	enhancer	E_564				GTAAAATTATGTCAACATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5717
enhrx-84748	chr19	40595222	40597598	40089315	40091691	52645	hg19	N/A	N/A	N/A	Enhatls90852	enhancer	E_564				GTAAAATTATGTCAACATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"SAMD4B,AKT2"	direct	Highly Significant	NA					ZNF780A	chr19	40069151	40090943	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5718
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52646	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				ATCCAAAGATGTTTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52647	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				ATCCAAAGATGTTTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52648	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				ATCCAAAGATGTTTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52649	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				TGCACTATGTTTATTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52650	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				TGCACTATGTTTATTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52651	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				TGCACTATGTTTATTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52652	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				AGGAGGGATTCTTGGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52653	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				AGGAGGGATTCTTGGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52654	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				AGGAGGGATTCTTGGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52655	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GTATGAGGTCATCTTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52656	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				GTATGAGGTCATCTTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52657	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GTATGAGGTCATCTTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52658	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				TCATGACTCAGGCTTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52659	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				TCATGACTCAGGCTTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52660	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				TCATGACTCAGGCTTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52661	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				CACACTAGCTCACGTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52662	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				CACACTAGCTCACGTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52663	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				CACACTAGCTCACGTCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52664	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				CAGCTTGGACTAGCTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52665	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				CAGCTTGGACTAGCTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52666	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				CAGCTTGGACTAGCTGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52667	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GCCTTGGTGGAGGACGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52668	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				GCCTTGGTGGAGGACGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52669	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GCCTTGGTGGAGGACGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52670	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GGTCTGGGAAGTCCTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52671	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				GGTCTGGGAAGTCCTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52672	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GGTCTGGGAAGTCCTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52673	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GGAAGTAAAGGGTCAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	8332				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52674	hg19	N/A	enh5139	fant57011	Enhatls90981	enhancer	E_565				GGAAGTAAAGGGTCAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					LTBP4	chr19	40593165	40629818	16379				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84868	chr19	41151069	41153270	40645164	40647365	52675	hg19	N/A	enh5139	N/A	Enhatls90981	enhancer	E_565				GGAAGTAAAGGGTCAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					NUMBL	chr19	40665904	40690972	11915				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5838
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52676	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				ATCACTTTAGTTGGGAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52677	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				ATCACTTTAGTTGGGAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52678	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				ATCACTTTAGTTGGGAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52679	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				ATCACTTTAGTTGGGAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52680	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				CAGGGTTCATGGCCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52681	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				CAGGGTTCATGGCCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52682	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				CAGGGTTCATGGCCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52683	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				CAGGGTTCATGGCCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52684	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GGCGGTTCGCGTGAGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52685	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GGCGGTTCGCGTGAGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52686	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GGCGGTTCGCGTGAGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52687	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GGCGGTTCGCGTGAGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52688	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				AGGGGACTGGTGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52689	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				AGGGGACTGGTGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52690	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				AGGGGACTGGTGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52691	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				AGGGGACTGGTGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52692	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				CCAGCTCTCCAGAGCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52693	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				CCAGCTCTCCAGAGCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52694	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				CCAGCTCTCCAGAGCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52695	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				CCAGCTCTCCAGAGCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52696	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				CTTCTCTGTGTAGCGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52697	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				CTTCTCTGTGTAGCGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52698	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				CTTCTCTGTGTAGCGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52699	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				CTTCTCTGTGTAGCGTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52700	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				TGATTCCCACAATCGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52701	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				TGATTCCCACAATCGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52702	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				TGATTCCCACAATCGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52703	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				TGATTCCCACAATCGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52704	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				ATAAGTATCTTTTATAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52705	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				ATAAGTATCTTTTATAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52706	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				ATAAGTATCTTTTATAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52707	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				ATAAGTATCTTTTATAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52708	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				TTCTCGCCGTCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52709	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				TTCTCGCCGTCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52710	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				TTCTCGCCGTCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52711	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				TTCTCGCCGTCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52712	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				CAAGTGGCGTCGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52713	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				CAAGTGGCGTCGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52714	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				CAAGTGGCGTCGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52715	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				CAAGTGGCGTCGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52716	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GGAGGGGGAACGCAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52717	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GGAGGGGGAACGCAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52718	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GGAGGGGGAACGCAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52719	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GGAGGGGGAACGCAGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52720	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				AATGAACCTCGTGTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52721	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				AATGAACCTCGTGTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52722	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				AATGAACCTCGTGTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52723	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				AATGAACCTCGTGTAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52724	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GGTCACGTGCCCACCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52725	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GGTCACGTGCCCACCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52726	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GGTCACGTGCCCACCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52727	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GGTCACGTGCCCACCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	direct	Highly Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52728	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				AGGGCGGCTGGCACAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52729	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				AGGGCGGCTGGCACAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52730	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				AGGGCGGCTGGCACAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52731	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				AGGGCGGCTGGCACAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52732	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				AGGAGACTAAGCCGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52733	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				AGGAGACTAAGCCGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52734	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				AGGAGACTAAGCCGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52735	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				AGGAGACTAAGCCGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52736	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GCCGGGGCGACCCCGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52737	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GCCGGGGCGACCCCGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52738	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GCCGGGGCGACCCCGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52739	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GCCGGGGCGACCCCGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52740	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GGACGCGCGCCGGTTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52741	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GGACGCGCGCCGGTTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52742	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GGACGCGCGCCGGTTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52743	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GGACGCGCGCCGGTTACGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52744	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GGCAGGGCCTAAGGGCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52745	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GGCAGGGCCTAAGGGCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52746	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GGCAGGGCCTAAGGGCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52747	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GGCAGGGCCTAAGGGCCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52748	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				CGTTGGGGTGCCCTGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52749	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				CGTTGGGGTGCCCTGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52750	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				CGTTGGGGTGCCCTGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52751	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				CGTTGGGGTGCCCTGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84905	chr19	41301753	41310963	40795848	40805058	52752	hg19	N/A	N/A	fant57018	N/A	enhancer	E_566				GAGGTCCCGAGACTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5875
enhrx-84906	chr19	41301753	41310963	40795848	40805058	52753	hg19	N/A	N/A	N/A	Enhatls91017	enhancer	E_566				GAGGTCCCGAGACTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5876
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52754	hg19	N/A	enh18075	N/A	N/A	enhancer	E_566				GAGGTCCCGAGACTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84907	chr19	41301753	41310963	40795848	40805058	52755	hg19	N/A	enh18075	N/A	Enhatls91018	enhancer	E_566				GAGGTCCCGAGACTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AKT2	indirect	Non Significant	NA					EGLN2	chr19	40798995	40808434	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5877
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52756	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52757	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52758	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52759	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52760	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52761	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52762	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52763	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52764	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52765	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52766	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52767	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TACACACCAGGACACAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	indirect	Non Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52768	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52769	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52770	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52771	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52772	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52773	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52774	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52775	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52776	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52777	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52778	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52779	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				ACTCCATGTACGCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52780	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52781	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52782	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52783	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52784	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52785	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52786	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52787	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52788	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52789	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52790	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52791	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TAGATGTACATTGCGTCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52792	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52793	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52794	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52795	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52796	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52797	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52798	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52799	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52800	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52801	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52802	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52803	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GTATGCATACAAGCCAACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52804	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52805	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52806	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52807	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52808	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52809	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52810	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52811	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52812	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52813	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52814	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52815	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				AACGGCACACAGATATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52816	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52817	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52818	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52819	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52820	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52821	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52822	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52823	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52824	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52825	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52826	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52827	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TGAATCACACTTAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52828	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52829	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52830	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52831	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52832	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52833	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52834	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52835	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52836	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52837	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52838	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52839	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GAGGGACAGACGCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52840	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52841	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52842	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52843	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52844	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52845	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52846	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52847	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52848	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52849	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52850	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52851	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				CTCTCATTCTCTGGAAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52852	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52853	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52854	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52855	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52856	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52857	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52858	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52859	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52860	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52861	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52862	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52863	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GGCCTGCTCCTGTCGTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52864	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52865	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52866	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52867	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52868	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52869	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52870	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52871	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52872	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52873	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52874	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52875	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TGTCCCCTTCACTCAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52876	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52877	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52878	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52879	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52880	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52881	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52882	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52883	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52884	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52885	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52886	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52887	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GCCCCCGGTGACTCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52888	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52889	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52890	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52891	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52892	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52893	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52894	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52895	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52896	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52897	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52898	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52899	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GCCCCGCCAGGGTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52900	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52901	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52902	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52903	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52904	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52905	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52906	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52907	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52908	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52909	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52910	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52911	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				AGAAACAGTACAGTCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52912	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52913	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52914	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52915	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52916	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52917	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52918	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52919	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52920	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52921	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52922	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52923	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				GTAGGGGAGCTCCTCAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52924	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52925	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52926	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52927	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52928	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52929	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52930	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52931	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52932	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52933	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52934	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52935	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				TTCCTTTTCTCCGTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84960	chr19	41722516	41736933	41216611	41231028	52936	hg19	N/A	N/A	N/A	Enhatls91080	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5930
enhrx-84961	chr19	41722516	41736933	41216611	41231028	52937	hg19	N/A	N/A	N/A	Enhatls91081	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5931
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52938	hg19	N/A	N/A	N/A	Enhatls91082	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52939	hg19	N/A	enh32942	N/A	Enhatls91082	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52940	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52941	hg19	N/A	enh32942	fant57025	N/A	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52942	hg19	N/A	enh32942	N/A	N/A	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52943	hg19	N/A	enh32942	fant57026	N/A	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84962	chr19	41722516	41736933	41216611	41231028	52944	hg19	N/A	N/A	fant57026	N/A	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5932
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52945	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52946	hg19	N/A	N/A	fant57027	Enhatls91083	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84963	chr19	41722516	41736933	41216611	41231028	52947	hg19	N/A	N/A	N/A	Enhatls91083	enhancer	E_567				ACCATCCACAGATACACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"ARHGEF1,AKT2"	direct	Highly Significant	NA					AXL	chr19	41219222	41261766	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5933
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52948	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52949	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52950	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52951	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52952	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52953	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52954	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52955	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52956	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GATCCCCCACTCCAGGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52957	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52958	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52959	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52960	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52961	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52962	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52963	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52964	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52965	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GCTGTATTACTCAGTGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52966	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52967	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52968	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52969	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52970	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52971	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52972	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52973	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52974	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCCCCGTGATCCACAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52975	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52976	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52977	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52978	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52979	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52980	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52981	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52982	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52983	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AAATTGTGGTTGGGCAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52984	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52985	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52986	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52987	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52988	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52989	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52990	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52991	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52992	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TACACTCCCCAAATGCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52993	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52994	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52995	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52996	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52997	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52998	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	52999	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53000	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53001	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCGGTGGCTGAGTCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53002	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53003	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53004	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53005	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53006	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53007	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53008	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53009	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53010	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CCCGTGGGGCAGGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53011	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53012	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53013	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53014	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53015	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53016	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53017	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53018	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53019	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AGGCGGCCCGGGGCCACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53020	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53021	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53022	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53023	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53024	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53025	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53026	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53027	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53028	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				CTGCGGTCGGCCACAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53029	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53030	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53031	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53032	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53033	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53034	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53035	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53036	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53037	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGGCACAGCCCCACAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53038	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53039	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53040	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53041	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53042	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53043	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53044	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53045	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53046	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GTCATGAGGGCGTGTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53047	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53048	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53049	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53050	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53051	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53052	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53053	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53054	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53055	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				GACGGAGCAGACACACCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53056	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53057	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53058	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53059	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53060	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53061	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53062	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53063	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53064	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				TGTCTGGGCGTGACGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53065	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53066	hg19	N/A	enh5145	fant57032	Enhatls91110	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53067	hg19	N/A	enh5145	N/A	Enhatls91110	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53068	hg19	N/A	enh5145	N/A	N/A	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53069	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	13				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53070	hg19	N/A	enh5145	fant57033	Enhatls91111	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	867				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53071	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CCDC97	chr19	41310171	41324873	1750				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53072	hg19	N/A	enh5145	fant57034	Enhatls91111	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	1037				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-84989	chr19	41826915	41835193	41321010	41329288	53073	hg19	N/A	enh5145	N/A	Enhatls91111	enhancer	E_568				AATTGTGCGTGTGTGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					TGFB1	chr19	41330322	41353922	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5959
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53074	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53075	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53076	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53077	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53078	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53079	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53080	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53081	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53082	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53083	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53084	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53085	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53086	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53087	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GAAGCATGTGTGACAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53088	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53089	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53090	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53091	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53092	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53093	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53094	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53095	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53096	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53097	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53098	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53099	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53100	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53101	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGTACAACCTCACACGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53102	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53103	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53104	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53105	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53106	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53107	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53108	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53109	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53110	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53111	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53112	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53113	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53114	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53115	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTATGTGAGGTGTGACAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53116	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53117	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53118	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53119	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53120	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53121	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53122	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53123	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53124	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53125	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53126	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53127	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53128	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53129	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TGGGGTGTGTAGGAGATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53130	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53131	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53132	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53133	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53134	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53135	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53136	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53137	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53138	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53139	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53140	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53141	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53142	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53143	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				CGCGCAGTTTGTCTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53144	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53145	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53146	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53147	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53148	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53149	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53150	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53151	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53152	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53153	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53154	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53155	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53156	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53157	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCGAGGAACACGCTCACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53158	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53159	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53160	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53161	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53162	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53163	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53164	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53165	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53166	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53167	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53168	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53169	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53170	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53171	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TTCGGGGCGCCGCGCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53172	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53173	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53174	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53175	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53176	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53177	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53178	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53179	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53180	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53181	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53182	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53183	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53184	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53185	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTGGCCCCGAGCCGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53186	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53187	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53188	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53189	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53190	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53191	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53192	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53193	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53194	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53195	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53196	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53197	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53198	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53199	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGCGGGGCCTGACCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53200	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53201	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53202	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53203	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53204	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53205	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53206	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53207	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53208	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53209	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53210	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53211	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53212	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53213	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GCTTGCGCGGAAGGCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53214	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53215	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53216	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53217	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53218	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53219	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53220	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53221	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53222	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53223	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53224	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53225	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53226	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53227	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGGAGCGCGTAGTAGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53228	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53229	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53230	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53231	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53232	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53233	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53234	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53235	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53236	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53237	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53238	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53239	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53240	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53241	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GGTCGACCTCCGGCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53242	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53243	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53244	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53245	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53246	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53247	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53248	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53249	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53250	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53251	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53252	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53253	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53254	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53255	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				GTTACCCGCCGGAGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53256	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53257	hg19	N/A	N/A	fant57080	Enhatls91293	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53258	hg19	N/A	N/A	N/A	Enhatls91293	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53259	hg19	N/A	enh5156	N/A	Enhatls91293	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53260	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53261	hg19	N/A	enh5156	fant57081	N/A	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53262	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53263	hg19	N/A	enh5156	fant57082	N/A	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85163	chr19	42769881	42790461	42265729	42286309	53264	hg19	N/A	enh5156	N/A	N/A	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6133
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53265	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53266	hg19	N/A	N/A	fant57083	Enhatls91294	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53267	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53268	hg19	N/A	N/A	fant57084	Enhatls91294	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85164	chr19	42769881	42790461	42265729	42286309	53269	hg19	N/A	N/A	N/A	Enhatls91294	enhancer	E_569				TCACGGGGCGCGCGGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					CIC	chr19	42268536	42295797	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6134
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53270	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CTGTGCCCAGCCATCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53271	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				CTGTGCCCAGCCATCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53272	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CTGTGCCCAGCCATCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53273	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CAAGCTTGAAATTTGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53274	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				CAAGCTTGAAATTTGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53275	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CAAGCTTGAAATTTGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53276	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GTGAGCTCCACAGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53277	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				GTGAGCTCCACAGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53278	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GTGAGCTCCACAGCAGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53279	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCAAAGATTACAACAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53280	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				GCAAAGATTACAACAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53281	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCAAAGATTACAACAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53282	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCATAGGCCAGGCTAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53283	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				GCATAGGCCAGGCTAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53284	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCATAGGCCAGGCTAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53285	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				AACACCCTTACTTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53286	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				AACACCCTTACTTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53287	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				AACACCCTTACTTTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53288	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CAAATGACATTTGATCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53289	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				CAAATGACATTTGATCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53290	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CAAATGACATTTGATCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53291	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCTGGCTGAGCCATTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53292	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				GCTGGCTGAGCCATTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53293	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GCTGGCTGAGCCATTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53294	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GATGGAATCATGCGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53295	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				GATGGAATCATGCGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53296	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				GATGGAATCATGCGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53297	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CATTTCCAAGGATGATTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53298	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				CATTTCCAAGGATGATTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53299	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CATTTCCAAGGATGATTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53300	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CTCCAAGTCTGCCAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53301	hg19	N/A	enh18084	fant57094	Enhatls91401	enhancer	E_570				CTCCAAGTCTGCCAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	15130				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85265	chr19	43354599	43356583	42850447	42852431	53302	hg19	N/A	enh18084	N/A	Enhatls91401	enhancer	E_570				CTCCAAGTCTGCCAAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF1	direct	Highly Significant	NA					PSG1	chr19	42866463	42879719	13782				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6235
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53303	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				TCTGGTTTATCACACACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53304	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				TCTGGTTTATCACACACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53305	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TCTGGTTTATCACACACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53306	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TCTGGTTTATCACACACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53307	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GGAGGCTGTGAGATATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53308	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GGAGGCTGTGAGATATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53309	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GGAGGCTGTGAGATATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53310	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GGAGGCTGTGAGATATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53311	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				TTTTAACCCAAAAGTAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53312	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				TTTTAACCCAAAAGTAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53313	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TTTTAACCCAAAAGTAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53314	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TTTTAACCCAAAAGTAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53315	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				AGATCTTTGCCTCCCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53316	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				AGATCTTTGCCTCCCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53317	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				AGATCTTTGCCTCCCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53318	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				AGATCTTTGCCTCCCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53319	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GCATGTACTGTTCTTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53320	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GCATGTACTGTTCTTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53321	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCATGTACTGTTCTTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53322	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCATGTACTGTTCTTTCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53323	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GTCAAAAGTATCTCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53324	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GTCAAAAGTATCTCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53325	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GTCAAAAGTATCTCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53326	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GTCAAAAGTATCTCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53327	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				ATGGTGATTGGAATTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53328	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				ATGGTGATTGGAATTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53329	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				ATGGTGATTGGAATTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53330	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				ATGGTGATTGGAATTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53331	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				CCTGGAGCTCAGTTAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53332	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				CCTGGAGCTCAGTTAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53333	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				CCTGGAGCTCAGTTAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53334	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				CCTGGAGCTCAGTTAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53335	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GGTGTGAGACAGCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53336	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GGTGTGAGACAGCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53337	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GGTGTGAGACAGCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53338	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GGTGTGAGACAGCCGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53339	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				TGAAGGGTGAGGACAACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53340	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				TGAAGGGTGAGGACAACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53341	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGAAGGGTGAGGACAACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53342	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGAAGGGTGAGGACAACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53343	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				TGCCATGTCAGGTGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53344	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				TGCCATGTCAGGTGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53345	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGCCATGTCAGGTGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53346	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGCCATGTCAGGTGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53347	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				AGGAATTCCTAGTCCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53348	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				AGGAATTCCTAGTCCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53349	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				AGGAATTCCTAGTCCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53350	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				AGGAATTCCTAGTCCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53351	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GCAATGCTGGCGAAACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53352	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GCAATGCTGGCGAAACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53353	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCAATGCTGGCGAAACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53354	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCAATGCTGGCGAAACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53355	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GCTCACAAAATACCAGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53356	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GCTCACAAAATACCAGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53357	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCTCACAAAATACCAGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53358	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCTCACAAAATACCAGCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53359	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				GCAGAGTTGGCTGTGCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53360	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				GCAGAGTTGGCTGTGCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53361	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCAGAGTTGGCTGTGCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53362	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				GCAGAGTTGGCTGTGCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53363	hg19	N/A	enh18106	N/A	Enhatls91891	enhancer	E_573				TGCTCTGTTGCCCAGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85743	chr19	46076946	46096119	45573688	45592861	53364	hg19	N/A	N/A	N/A	Enhatls91891	enhancer	E_573				TGCTCTGTTGCCCAGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6713
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53365	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGCTCTGTTGCCCAGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					OPA3	chr19	45527766	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85744	chr19	46076946	46096119	45573688	45592861	53366	hg19	N/A	N/A	N/A	Enhatls91892	enhancer	E_573				TGCTCTGTTGCCCAGACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					GPR4	chr19	45589763	45602212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6714
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53367	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GTATAAAGCAGAGAGCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53368	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GCAGCAGGTCACCCCTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53369	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GAATGTGGCTCCCCGGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53370	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GCGGGAAGACACACTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53371	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GTTCTCCAGAGTGGAAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53372	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GCCAGGCCTGAGAAACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53373	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				ACACCGAGGACTTTGATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53374	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				GGATGCTCTTCTCCCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85785	chr19	46284254	46289502	45780996	45786244	53375	hg19	N/A	enh110943	N/A	N/A	enhancer	E_574				TTCCTGCTATGAAAAGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					DMPK	chr19	45769716	45782496	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6755
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53376	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				TTCAAAAGCCGTGTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53377	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GAAATCATAATAACTTTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53378	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GGTTGAGATTTGTCATCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53379	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GCATGGGGAGATAGTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53380	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GCGCGGCCTACCCTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53381	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GGTTGTTCCCCAGAGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53382	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				CCAATTGGCTAACTAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53383	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				CCAATCAGAAGCGAGAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53384	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				AGTGGCGGTTGCGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53385	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				GGGAGGGTGCCCTTTAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85823	chr19	46498703	46500482	45995445	45997224	53386	hg19	N/A	N/A	N/A	Enhatls91974	enhancer	E_575				CTGAGCGCAGCATGTGAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					CCDC61	chr19	45995460	46018616	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6793
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53387	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				TAACTCTATGAGTCACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53388	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				AGTCCACTATAGGAAAACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53389	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				AATGTGAACAGGAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53390	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				GCCAACCCAGAATCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53391	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				CCCTGGCAGTGTTCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53392	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				TTAGGAGTCAGAGTTGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53393	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				CCCAGCCTTGAGCAGTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53394	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				GGGTATGACTCACATCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53395	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				TCAGAACTGGGTTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53396	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				TCATAGGCCTTGGGATACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53397	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				ACTCATAGGTGGAGCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85849	chr19	46790782	46793336	46287525	46290079	53398	hg19	N/A	enh32962	N/A	Enhatls92005	enhancer	E_576				AGCTAGGTCCCAGGGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR4	direct	Highly Significant	NA					HIF3A	chr19	46297041	46343433	5464				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6819
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53399	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				AGAAGAAGAAGAAGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53400	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				AGAAGAAGAAGAAGAAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53401	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GTGGGGGAGGATTTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53402	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GTGGGGGAGGATTTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53403	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GTCAGGTAAGTAACTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53404	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GTCAGGTAAGTAACTTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53405	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GCGGGGGCAGAAACACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53406	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GCGGGGGCAGAAACACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53407	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				CTGCTAGGAGAGAGATTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53408	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				CTGCTAGGAGAGAGATTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53409	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				TGAGATTCAAGATACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53410	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				TGAGATTCAAGATACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53411	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GTAGTGAGTAAGCAGGAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53412	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GTAGTGAGTAAGCAGGAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53413	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				TCCCCGCCCACTCTATTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53414	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				TCCCCGCCCACTCTATTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53415	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GTTTGTATCTTCCGTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53416	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GTTTGTATCTTCCGTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53417	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GCGTGCAGGCAAATGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53418	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GCGTGCAGGCAAATGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53419	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				CTTCGACTACATTCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53420	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				CTTCGACTACATTCACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53421	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				GAGACGGAGGGCGGGGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53422	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				GAGACGGAGGGCGGGGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-85932	chr19	47538428	47541273	47035170	47038015	53423	hg19	N/A	N/A	N/A	Enhatls92105	enhancer	E_578				CTTAGAATTACCGATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6902
enhrx-85933	chr19	47538428	47541273	47035170	47038015	53424	hg19	N/A	N/A	N/A	Enhatls92106	enhancer	E_578				CTTAGAATTACCGATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NPAS1	chr19	47019836	47045775	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6903
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53425	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53426	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53427	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53428	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53429	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53430	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53431	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53432	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TGACTCTTCACAACAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53433	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53434	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53435	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53436	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53437	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53438	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53439	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53440	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CTGAGTGAGCTCTAGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53441	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53442	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53443	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53444	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53445	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53446	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53447	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53448	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				AAGGCAGAGTGGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53449	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53450	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53451	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53452	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53453	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53454	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53455	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53456	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TTGGGTCAGGCACTGGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53457	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53458	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53459	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53460	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53461	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53462	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53463	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53464	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGGCTGACCACTCAGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53465	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53466	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53467	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53468	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53469	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53470	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53471	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53472	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTCATGGTGATGTCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53473	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53474	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53475	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53476	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53477	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53478	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53479	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53480	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CCATAAAAACTCAACCATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53481	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53482	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53483	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53484	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53485	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53486	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53487	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53488	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TTCAAAGAGCCCTGATTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53489	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53490	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53491	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53492	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53493	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53494	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53495	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53496	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				ACCAATTCTGTTCCGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53497	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53498	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53499	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53500	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53501	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53502	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53503	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53504	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TCTATGCCTGGCCTGGTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53505	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53506	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53507	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53508	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53509	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53510	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53511	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53512	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTGTGGTCAGAGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53513	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53514	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53515	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53516	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53517	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53518	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53519	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53520	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CAGTGTGCTAACTCAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53521	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53522	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53523	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53524	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53525	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53526	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53527	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53528	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGAATCTGTGCTTTGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53529	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53530	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53531	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53532	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53533	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53534	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53535	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53536	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				CCTTGAATCCACCCTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53537	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53538	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53539	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53540	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53541	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53542	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53543	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53544	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GGAGGTTCCTGGATCAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53545	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53546	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53547	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53548	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53549	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53550	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53551	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53552	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				TCAGATGGAACTTTCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53553	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53554	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53555	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53556	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53557	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53558	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53559	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53560	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GTTTAAGGAGCAGCGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53561	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53562	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53563	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53564	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53565	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53566	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53567	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53568	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GAGCGCAAGGTGAATTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53569	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53570	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53571	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53572	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53573	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53574	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53575	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53576	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GAAGAAAGAGACTGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53577	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53578	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53579	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53580	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53581	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53582	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53583	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53584	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				AGAGATGGAGAGACAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53585	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53586	hg19	N/A	enh18128	fant57300	Enhatls92219	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53587	hg19	N/A	enh18128	N/A	Enhatls92219	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53588	hg19	N/A	enh18128	N/A	N/A	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53589	hg19	N/A	enh18128	N/A	Enhatls92220	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53590	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53591	hg19	N/A	N/A	fant57301	Enhatls92220	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86043	chr19	48223135	48234246	47719878	47730989	53592	hg19	N/A	N/A	N/A	Enhatls92220	enhancer	E_582				GACCCGCGGGAACGAACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EHD2	chr19	47713421	47743134	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7013
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53593	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				GGAGTGCAGTGGAAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53594	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				GGAGTGCAGTGGAAGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53595	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				CCGGGAAAGGTGTTCGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53596	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				CCGGGAAAGGTGTTCGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53597	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				AGATTCCTAACGGCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53598	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				AGATTCCTAACGGCGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53599	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				AAGTACGTCACGGAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53600	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				AAGTACGTCACGGAAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53601	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				CAGCCCCAGGAAACCAGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53602	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				CAGCCCCAGGAAACCAGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53603	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				ACCCAGCGCTGAGGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53604	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				ACCCAGCGCTGAGGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53605	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				GGGCTGGCGGCGGCTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53606	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				GGGCTGGCGGCGGCTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53607	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				CGTTGGGCGGGACTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53608	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				CGTTGGGCGGGACTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86045	chr19	48243808	48250511	47740551	47747254	53609	hg19	N/A	N/A	N/A	Enhatls92222	enhancer	E_583				TGCTTGCGTGGACTCGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7015
enhrx-86046	chr19	48243808	48250511	47740551	47747254	53610	hg19	N/A	N/A	N/A	Enhatls92223	enhancer	E_583				TGCTTGCGTGGACTCGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					NOP53	chr19	47745545	47757058	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7016
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53611	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				ATTGGGTGCAATTAAATAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53612	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				GGAGGGCTGTTTCATCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53613	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				GGGCGTGTGCGCATGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53614	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				CCGCGACCTCCTCCCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53615	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				GGAGGGCTGTTTAAAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53616	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				TCATCCGTGGGATCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86109	chr19	48613366	48614782	48110109	48111525	53617	hg19	N/A	N/A	N/A	Enhatls92284	enhancer	E_584				TTGTCGTTATATAACTATAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					PLA2G4C	chr19	48047842	48110817	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7079
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53618	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53619	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53620	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53621	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53622	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53623	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GGGCGGCGAGGTCCTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53624	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53625	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53626	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53627	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53628	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53629	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				CCGCCCATCACAGCTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53630	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53631	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53632	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53633	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53634	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53635	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				AACTTCGAGGGGCGGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53636	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53637	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53638	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53639	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53640	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53641	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GCTTCGCAGACAGCGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53642	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53643	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53644	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53645	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53646	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53647	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				TGAAGGGCGGGCTAATCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53648	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53649	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53650	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53651	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53652	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53653	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				TGAGGTCTCACTAGTACCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53654	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53655	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53656	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53657	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53658	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53659	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				AAGCCCTCGAAGCCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53660	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53661	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53662	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53663	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53664	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53665	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				ACGTTAAATTAAGGATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53666	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53667	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53668	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53669	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53670	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53671	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GCTTGCGTAGTGAACCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53672	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53673	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53674	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53675	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53676	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53677	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GGGCGTGGCCAGAAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53678	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53679	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53680	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53681	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53682	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53683	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GCACGCCCCCTCCGCGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53684	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53685	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53686	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53687	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53688	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53689	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				AGCTCAGCTCATAATCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53690	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53691	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53692	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53693	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53694	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53695	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				CGCCAGGCTTGGGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53696	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53697	hg19	N/A	enh5191	N/A	Enhatls92336	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53698	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53699	hg19	N/A	enh5191	N/A	Enhatls92337	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53700	hg19	N/A	enh5191	N/A	N/A	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48823562	48831090	48320305	48327833	53701	hg19	N/A	enh5191	N/A	Enhatls92338	enhancer	E_585				GAAGATGGAAACTTGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53702	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				CTCAGGTGCCTTCCTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53703	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				CTCAGGTGCCTTCCTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53704	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				CTCAGGTGCCTTCCTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53705	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				CTCAGGTGCCTTCCTCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53706	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCCAGGTTGGGAGCGAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53707	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCCAGGTTGGGAGCGAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53708	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCCAGGTTGGGAGCGAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53709	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCCAGGTTGGGAGCGAGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53710	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				ATTGCTGCTGCTTAAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53711	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				ATTGCTGCTGCTTAAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53712	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				ATTGCTGCTGCTTAAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53713	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				ATTGCTGCTGCTTAAATGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53714	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCCGGTTGTCGCTGCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53715	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCCGGTTGTCGCTGCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53716	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCCGGTTGTCGCTGCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53717	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCCGGTTGTCGCTGCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53718	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GTCACTGGACGTTTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53719	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GTCACTGGACGTTTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53720	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GTCACTGGACGTTTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53721	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GTCACTGGACGTTTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53722	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				AATGATATATAGTCTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53723	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				AATGATATATAGTCTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53724	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				AATGATATATAGTCTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53725	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				AATGATATATAGTCTCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53726	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GTGAGGGTGGGACTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53727	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GTGAGGGTGGGACTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53728	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GTGAGGGTGGGACTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53729	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GTGAGGGTGGGACTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53730	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GGCTGTTCATCGAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53731	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GGCTGTTCATCGAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53732	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GGCTGTTCATCGAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53733	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GGCTGTTCATCGAAGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53734	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				TCCAACTTCCAATAACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53735	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				TCCAACTTCCAATAACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53736	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				TCCAACTTCCAATAACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53737	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				TCCAACTTCCAATAACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53738	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				ACAGCCTGTCGTGAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53739	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				ACAGCCTGTCGTGAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53740	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				ACAGCCTGTCGTGAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53741	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				ACAGCCTGTCGTGAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53742	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				TCTAGTTTGGGGAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53743	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				TCTAGTTTGGGGAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53744	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				TCTAGTTTGGGGAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53745	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				TCTAGTTTGGGGAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53746	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				AGGTGACCTTCAACGGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53747	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				AGGTGACCTTCAACGGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53748	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				AGGTGACCTTCAACGGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53749	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				AGGTGACCTTCAACGGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53750	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCCAGTTCTCCACCTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53751	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCCAGTTCTCCACCTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53752	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCCAGTTCTCCACCTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53753	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCCAGTTCTCCACCTCCGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53754	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				AGGGGCGTAGGGCAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53755	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				AGGGGCGTAGGGCAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53756	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				AGGGGCGTAGGGCAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53757	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				AGGGGCGTAGGGCAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53758	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				AGGGGAGCGGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53759	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				AGGGGAGCGGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53760	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				AGGGGAGCGGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53761	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				AGGGGAGCGGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53762	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GTGGGGGCTCCTGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53763	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GTGGGGGCTCCTGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53764	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GTGGGGGCTCCTGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53765	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GTGGGGGCTCCTGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53766	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GAGAGTGTCAGCTCAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53767	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GAGAGTGTCAGCTCAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53768	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GAGAGTGTCAGCTCAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53769	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GAGAGTGTCAGCTCAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53770	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				ACCAGGCTGAGGTTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53771	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				ACCAGGCTGAGGTTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53772	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				ACCAGGCTGAGGTTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53773	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				ACCAGGCTGAGGTTAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53774	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GGACGCATCTCGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53775	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GGACGCATCTCGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53776	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GGACGCATCTCGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53777	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GGACGCATCTCGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53778	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCAGGACGAGCACACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53779	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCAGGACGAGCACACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53780	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCAGGACGAGCACACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53781	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCAGGACGAGCACACCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53782	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCTGCCCGAACATCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53783	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCTGCCCGAACATCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53784	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCTGCCCGAACATCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53785	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCTGCCCGAACATCTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53786	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				CCACCCATACACAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53787	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				CCACCCATACACAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53788	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				CCACCCATACACAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53789	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				CCACCCATACACAGCCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53790	hg19	N/A	enh5191	N/A	Enhatls92339	enhancer	E_586				GCTCAGTCGAGGGATCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					EMP3	chr19	48321508	48330553	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86164	chr19	48834748	48837674	48331491	48334417	53791	hg19	N/A	N/A	N/A	Enhatls92339	enhancer	E_586				GCTCAGTCGAGGGATCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	3				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7134
enhrx-86165	chr19	48834748	48837674	48331491	48334417	53792	hg19	N/A	N/A	N/A	Enhatls92340	enhancer	E_586				GCTCAGTCGAGGGATCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7135
enhrx-86166	chr19	48834748	48837674	48331491	48334417	53793	hg19	N/A	N/A	N/A	Enhatls92341	enhancer	E_586				GCTCAGTCGAGGGATCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA					TMEM143	chr19	48332355	48364059	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7136
enhrx-lit763	chr19	48866327	48867936	48363070	48364679	53794	hg19					enhancer	E_587				CTTGTTCTGAGGGCTTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit764	chr19	48866327	48867936	48363070	48364679	53795	hg19					enhancer	E_587				CTTCGTGTTTCCCTAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit765	chr19	48866327	48867936	48363070	48364679	53796	hg19					enhancer	E_587				GCAGCTCTCTGCAGCAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit766	chr19	48866327	48867936	48363070	48364679	53797	hg19					enhancer	E_587				CAGGCGGTACCTGTATTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit767	chr19	48866327	48867936	48363070	48364679	53798	hg19					enhancer	E_587				TACTGCTGGGCCCAGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit768	chr19	48866327	48867936	48363070	48364679	53799	hg19					enhancer	E_587				CCAGCGATGAGAGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit769	chr19	48866327	48867936	48363070	48364679	53800	hg19					enhancer	E_587				GCCATGCTGCATGTGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit770	chr19	48866327	48867936	48363070	48364679	53801	hg19					enhancer	E_587				AACAGGGGCTTTGAGGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit771	chr19	48866327	48867936	48363070	48364679	53802	hg19					enhancer	E_587				AGAAACGTTGTACCACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit772	chr19	48866327	48867936	48363070	48364679	53803	hg19					enhancer	E_587				ATCGGGGGATTGCATGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit773	chr19	48866327	48867936	48363070	48364679	53804	hg19					enhancer	E_587				TGCTGGGTGAAGCCGAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit774	chr19	48866327	48867936	48363070	48364679	53805	hg19					enhancer	E_587				AGGGAGTCGGCGGTGAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit775	chr19	48866327	48867936	48363070	48364679	53806	hg19					enhancer	E_587				GCATGCGTCGCGCCCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit776	chr19	48866327	48867936	48363070	48364679	53807	hg19					enhancer	E_587				CCTTGTCAGCTTGCTACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit777	chr19	48866327	48867936	48363070	48364679	53808	hg19					enhancer	E_587				TCAGGAGCTGACACGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit778	chr19	48866327	48867936	48363070	48364679	53809	hg19					enhancer	E_587				AGCGAAAAGGCGGGAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit779	chr19	48866327	48867936	48363070	48364679	53810	hg19					enhancer	E_587				GGCCAATCTGCGTCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit780	chr19	48866327	48867936	48363070	48364679	53811	hg19					enhancer	E_587				GCCATTCCAGGTCCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CRX	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53812	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53813	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53814	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53815	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53816	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53817	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53818	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53819	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53820	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53821	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GTGAAAATTGAGGTCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53822	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53823	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53824	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53825	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53826	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53827	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53828	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53829	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53830	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53831	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				ACAAGGGAGAATGAACTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53832	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53833	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53834	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53835	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53836	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53837	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53838	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53839	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53840	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53841	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCCTGGCTCCTGTTCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53842	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53843	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53844	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53845	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53846	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53847	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53848	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53849	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53850	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53851	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GAGGCTGGCCTCAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53852	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53853	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53854	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53855	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53856	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53857	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53858	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53859	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53860	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53861	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCGGACCGCCAGCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53862	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53863	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53864	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53865	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53866	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53867	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53868	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53869	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53870	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53871	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCGCCTCCGAACAGCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53872	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53873	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53874	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53875	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53876	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53877	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53878	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53879	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53880	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53881	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GTCCGCCCCCTCGTCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53882	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53883	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53884	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53885	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53886	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53887	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53888	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53889	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53890	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53891	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				TGAGACGCAGCTCCTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53892	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53893	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53894	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53895	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53896	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53897	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53898	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53899	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53900	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53901	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCAGCCAAGGAGAAGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53902	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53903	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53904	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53905	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53906	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53907	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53908	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53909	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53910	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53911	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GACTCATCCCGCCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53912	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53913	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53914	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53915	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53916	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53917	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53918	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53919	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53920	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53921	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTAGCAGCTCCAGAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53922	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53923	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53924	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53925	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53926	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53927	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53928	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53929	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53930	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53931	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GCCGCCAGCTACCCTCCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53932	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53933	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53934	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53935	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53936	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53937	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53938	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53939	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53940	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53941	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTCCGCTCCCACATGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53942	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53943	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53944	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53945	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53946	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53947	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53948	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53949	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53950	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53951	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				GGTCAAGGGAGCCCTAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53952	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53953	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53954	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53955	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53956	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53957	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53958	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53959	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53960	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53961	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				TCTGTGTCTGGCTGGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53962	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53963	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53964	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53965	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53966	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53967	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53968	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53969	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53970	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53971	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				AGAACTGCAATCCCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89337	chr2	27291915	27310087	27069047	27087219	53972	hg19	N/A	N/A	N/A	Enhatls95693	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1263
enhrx-89338	chr2	27291915	27310087	27069047	27087219	53973	hg19	N/A	N/A	N/A	Enhatls95694	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					AGBL5	chr2	27042363	27070618	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1264
enhrx-89339	chr2	27291915	27310087	27069047	27087219	53974	hg19	N/A	N/A	N/A	Enhatls95695	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1265
enhrx-89340	chr2	27291915	27310087	27069047	27087219	53975	hg19	N/A	N/A	N/A	Enhatls95696	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1266
enhrx-89341	chr2	27291915	27310087	27069047	27087219	53976	hg19	N/A	N/A	fant6328	N/A	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					OST4	chr2	27070471	27071654	584				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1267
enhrx-89342	chr2	27291915	27310087	27069047	27087219	53977	hg19	N/A	N/A	N/A	Enhatls95697	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1268
enhrx-89343	chr2	27291915	27310087	27069047	27087219	53978	hg19	N/A	N/A	N/A	Enhatls95698	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1269
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53979	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53980	hg19	N/A	N/A	fant6329	Enhatls95699	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89344	chr2	27291915	27310087	27069047	27087219	53981	hg19	N/A	N/A	N/A	Enhatls95699	enhancer	E_589				CCAGTGTTCAGATCACCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					EMILIN1	chr2	27078614	27086403	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1270
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53982	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53983	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53984	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53985	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53986	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53987	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				ACTCCCTGGGAGAAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53988	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53989	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53990	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53991	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53992	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53993	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				CCAGAGGCATGGCTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53994	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53995	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53996	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53997	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53998	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	53999	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				AGAGTTCCACTGCAGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54000	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54001	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54002	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54003	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54004	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54005	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				GGCCCCTGAGAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54006	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54007	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54008	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54009	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54010	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54011	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				TGTGACTCATTTGTAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54012	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54013	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54014	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54015	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54016	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54017	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				TGATGATGTCATCACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54018	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54019	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54020	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54021	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54022	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54023	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				TTAGAAGCAGGTAGAGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54024	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	11139				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54025	hg19	N/A	enh18388	fant6393	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10924				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54026	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	10216				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54027	hg19	N/A	enh18388	fant6394	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	9822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54028	hg19	N/A	enh18388	N/A	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	5017				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89543	chr2	28668418	28675367	28445551	28452500	54029	hg19	N/A	N/A	N/A	Enhatls95905	enhancer	E_590				GATGTGCTGCCCCCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1469
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54030	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54031	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54032	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54033	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54034	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54035	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54036	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTATATGCCCAGGTTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54037	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54038	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54039	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54040	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54041	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54042	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54043	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTAGGGGCGAGGCCCCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54044	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54045	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54046	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54047	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54048	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54049	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54050	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGCGGCGTTTAGTACATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54051	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54052	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54053	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54054	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54055	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54056	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54057	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CGGACTTCAGGATCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54058	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54059	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54060	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54061	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54062	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54063	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54064	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				AGGCTGGCGAAGGCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54065	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54066	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54067	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54068	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54069	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54070	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54071	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CACGGCGCTGCTGAAAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54072	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54073	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54074	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54075	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54076	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54077	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54078	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CTTATCCCAACTCTTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54079	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54080	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54081	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54082	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54083	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54084	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54085	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGAGACCCAGAGATGAGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54086	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54087	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54088	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54089	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54090	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54091	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54092	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TGTCACAACAGAGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54093	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54094	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54095	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54096	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54097	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54098	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54099	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				CAGTCTATAGGAAAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54100	hg19	N/A	enh18394	N/A	Enhatls95958	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54101	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54102	hg19	N/A	enh18394	N/A	Enhatls95959	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54103	hg19	N/A	enh18394	N/A	N/A	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54104	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54105	hg19	N/A	enh18394	fant6409	Enhatls95960	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28862751	28868596	28639885	28645730	54106	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_591				TTAAGCCGGGAGCATAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54107	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				TGACCCAGACCGAGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54108	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				TGTGACCCATGAGTCACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54109	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				CTTTTTCTGCCCACAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54110	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				GAGGTCTCAACCACCTAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54111	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				AAAAAACCAAGTTGCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54112	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				GATAACGTCATTATATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54113	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				GCAACTCATTTTACACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54114	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				AATTGTGTTTGTCTCCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54115	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				TGTGGTGCATTCTGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28869685	28878742	28646819	28655876	54116	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_592				GCTGGTGCGAGAATTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	direct	Highly Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54117	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				AAAACCCAGCTCAAACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54118	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				AGGAGAGCAAGCAGGAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54119	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				AAATGAAATTAAAGATATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54120	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				CAAATGACATCAGCCTTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54121	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				AGGAGTCCACTTACTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-89578	chr2	28881355	28882033	28658489	28659167	54122	hg19	N/A	enh18394	N/A	Enhatls95960	enhancer	E_593				AAAAATGAGCAAAGTCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SUPT7L	indirect	Non Significant	NA					PLB1	chr2	28457144	28644142	73				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1504
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54123	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				CAAAAGTGAACATCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54124	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				ACGGGTCCGATGTTGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54125	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				GACCAAATCTCCTTCCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54126	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				GCAGTCTGAACTGAATGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54127	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				GTTCTGCTGGTCAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54128	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				GAACAGTCTTCAGTTGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54129	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				TCTCCGTGGCAGATCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54130	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				CTGATGATACGTGCATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54131	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				ACGTGTCATCTCTTAGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90588	chr2	46298701	46304533	46071562	46077394	54132	hg19	N/A	enh18511	N/A	Enhatls97047	enhancer	E_595				GCTCACACTACACAAAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					PRKCE	chr2	45651344	46187990	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2514
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54133	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54134	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54135	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54136	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54137	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54138	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TGAACAACTAATAATAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54139	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54140	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54141	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54142	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54143	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54144	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				CTCAAATCTGCAGTACAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54145	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54146	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54147	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54148	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54149	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54150	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				AAATGCTCCTTTAAGTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54151	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54152	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54153	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54154	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54155	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54156	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				GAAACACTGCAATACAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54157	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54158	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54159	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54160	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54161	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54162	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				CCCACTCTATCCCATCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54163	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54164	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54165	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54166	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54167	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54168	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TGTGGTCTGAAAACATTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54169	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54170	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54171	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54172	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54173	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54174	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				TAAAATGTGAATGTATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54175	hg19	N/A	enh33290	N/A	Enhatls97082	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5796				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90615	chr2	46915743	46929456	46688604	46702317	54176	hg19	N/A	N/A	N/A	Enhatls97082	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	5001				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2541
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54177	hg19	N/A	N/A	N/A	Enhatls97083	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54178	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54179	hg19	N/A	enh33291	fant6957	Enhatls97083	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90616	chr2	46915743	46929456	46688604	46702317	54180	hg19	N/A	enh33291	N/A	Enhatls97083	enhancer	E_596				AAGTCATTAAAGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					SOCS5	chr2	46698951	46780244	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2542
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54181	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCAGACTCCTAAGAGTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54182	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCAGACTCCTAAGAGTTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54183	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				ATGTGTCACTTAAATGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54184	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				ATGTGTCACTTAAATGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54185	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TACGGGGCGGGGCCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54186	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TACGGGGCGGGGCCTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54187	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCTTAGCAGGGTTTAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54188	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCTTAGCAGGGTTTAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54189	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TAAAGCCTTTAAGAAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54190	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TAAAGCCTTTAAGAAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54191	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGGGGCGTCCAGAGAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54192	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGGGGCGTCCAGAGAGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54193	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CAACAGGGCGGGGCGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54194	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CAACAGGGCGGGGCGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54195	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CCATTTTTGTGACGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54196	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CCATTTTTGTGACGTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54197	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GGCTAAGAGCCCCGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54198	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GGCTAAGAGCCCCGATGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54199	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGTGAGCTCCGACTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54200	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGTGAGCTCCGACTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54201	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CCAGCGAGCCCGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54202	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CCAGCGAGCCCGGCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54203	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GTCCGCAGCTGGCGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54204	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GTCCGCAGCTGGCGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54205	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCCTCTGCTGTAGCAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54206	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCCTCTGCTGTAGCAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	direct	Highly Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54207	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GAGCCGCAGCCCGGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54208	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GAGCCGCAGCCCGGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54209	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCTGCCCACCCTCCGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54210	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GCTGCCCACCCTCCGCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54211	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TGGAAGGTGCGGCCAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54212	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TGGAAGGTGCGGCCAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54213	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GGTCCCAGTGGCCCTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54214	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GGTCCCAGTGGCCCTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54215	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CAGACGCTGAGCATGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54216	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				CAGACGCTGAGCATGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54217	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TTCCGGACACCGGTGAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54218	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				TTCCGGACACCGGTGAGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54219	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AAGCGCGCCCAGACAGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54220	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AAGCGCGCCCAGACAGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54221	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGTTAGCCACATTATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54222	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AGTTAGCCACATTATCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54223	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GACACCCCACCCTCGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54224	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				GACACCCCACCCTCGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54225	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AACGTCACTTGCGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					MCFD2	chr2	46901869	46941855	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-90627	chr2	47166326	47170918	46939187	46943779	54226	hg19	N/A	enh60806	N/A	N/A	enhancer	E_598				AACGTCACTTGCGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PRKCE	indirect	Non Significant	NA					TTC7A	chr2	46916156	47076123	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2553
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54227	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ACCTTTGCATCAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54228	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				ACCTTTGCATCAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54229	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ACCTTTGCATCAGAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54230	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				AAATGCATAAGCCTATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54231	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				AAATGCATAAGCCTATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54232	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				AAATGCATAAGCCTATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54233	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ATATCTATTTCTCAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54234	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				ATATCTATTTCTCAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54235	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ATATCTATTTCTCAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54236	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				TCTCCCACTGATCTCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54237	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				TCTCCCACTGATCTCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54238	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				TCTCCCACTGATCTCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	indirect	Non Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54239	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				GCAAGTCTCCCCACCCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54240	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				GCAAGTCTCCCCACCCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54241	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				GCAAGTCTCCCCACCCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54242	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				GTGGAAATAGTCTTCCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54243	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				GTGGAAATAGTCTTCCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54244	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				GTGGAAATAGTCTTCCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54245	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ACTCAGTGTAGTGCAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54246	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				ACTCAGTGTAGTGCAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54247	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ACTCAGTGTAGTGCAAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54248	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				AAATTGTTGAAGAATCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54249	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				AAATTGTTGAAGAATCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54250	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				AAATTGTTGAAGAATCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54251	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ATTACATAGGTAGGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	15014				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54252	hg19	N/A	enh18760	fant7957	Enhatls100117	enhancer	E_601				ATTACATAGGTAGGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	14841				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93486	chr2	101945315	101948127	101328853	101331665	54253	hg19	N/A	enh18760	N/A	Enhatls100117	enhancer	E_601				ATTACATAGGTAGGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					CREG2	chr2	101345549	101387503	9877				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5412
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54254	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TGGAGAGCCCTGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54255	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				TGGAGAGCCCTGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54256	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TGGAGAGCCCTGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54257	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				ACTGACTGCTAGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54258	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				ACTGACTGCTAGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54259	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				ACTGACTGCTAGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54260	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GAGAGAACAAATTCGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54261	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				GAGAGAACAAATTCGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54262	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GAGAGAACAAATTCGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54263	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TTATTCATCTCTTAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54264	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				TTATTCATCTCTTAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54265	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TTATTCATCTCTTAGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54266	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GAGCACAGTGACTTTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54267	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				GAGCACAGTGACTTTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54268	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GAGCACAGTGACTTTATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54269	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				AGGTCTGAGAGACCTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54270	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				AGGTCTGAGAGACCTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54271	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				AGGTCTGAGAGACCTCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54272	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TCCAGTGCAAATCTGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54273	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				TCCAGTGCAAATCTGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54274	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TCCAGTGCAAATCTGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54275	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				CCAACTATTCTTAAACCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54276	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				CCAACTATTCTTAAACCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54277	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				CCAACTATTCTTAAACCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54278	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TTGTTACAGCTGCAGGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54279	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				TTGTTACAGCTGCAGGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54280	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				TTGTTACAGCTGCAGGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54281	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GTGCGGGCAGATTTGGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54282	hg19	N/A	enh33523	fant7964	Enhatls100131	enhancer	E_602				GTGCGGGCAGATTTGGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93498	chr2	102059564	102065280	101443102	101448818	54283	hg19	N/A	enh33523	N/A	Enhatls100131	enhancer	E_602				GTGCGGGCAGATTTGGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					RFX8	chr2	101397358	101475112	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5424
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54284	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GACACGGCCAGTAAAACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54285	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GACACGGCCAGTAAAACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54286	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GACACGGCCAGTAAAACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54287	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCATACACAGACGTGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54288	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TCATACACAGACGTGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54289	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCATACACAGACGTGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54290	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CTGCCAATGCTCCCTACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54291	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				CTGCCAATGCTCCCTACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54292	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CTGCCAATGCTCCCTACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54293	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTTATTCACTCCAGGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54294	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TTTATTCACTCCAGGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54295	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTTATTCACTCCAGGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54296	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCAAATTAATGCTATAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54297	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TCAAATTAATGCTATAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54298	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCAAATTAATGCTATAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54299	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TAGCTCTGTACCTATACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54300	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TAGCTCTGTACCTATACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54301	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TAGCTCTGTACCTATACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54302	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTAAATCAAAGGCAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54303	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TTAAATCAAAGGCAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54304	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTAAATCAAAGGCAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54305	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GCATGTTATGGGGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54306	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GCATGTTATGGGGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54307	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GCATGTTATGGGGTAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54308	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTTTATGTTCAAAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54309	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GTTTATGTTCAAAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54310	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTTTATGTTCAAAATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54311	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGTGGAAATGCATTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54312	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TGTGGAAATGCATTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54313	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGTGGAAATGCATTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54314	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCTTCCAGACATTTTAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54315	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TCTTCCAGACATTTTAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54316	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCTTCCAGACATTTTAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54317	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCTGGCAAATTGCCACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54318	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TCTGGCAAATTGCCACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54319	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCTGGCAAATTGCCACACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54320	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GAAAAATCTTCACTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54321	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GAAAAATCTTCACTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54322	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GAAAAATCTTCACTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54323	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CCTGGGATTTGGAACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54324	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				CCTGGGATTTGGAACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54325	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CCTGGGATTTGGAACACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54326	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGAGTTGTCAGCTCTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54327	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TGAGTTGTCAGCTCTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54328	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGAGTTGTCAGCTCTTGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54329	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTCTCACTGGGGCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54330	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GTCTCACTGGGGCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54331	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTCTCACTGGGGCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54332	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTGCTTGGCTCTCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54333	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				GTGCTTGGCTCTCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54334	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				GTGCTTGGCTCTCCCTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54335	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TAGTTTCCAGCAGCTGTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54336	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TAGTTTCCAGCAGCTGTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54337	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TAGTTTCCAGCAGCTGTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54338	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGTCACATTTCCACAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54339	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TGTCACATTTCCACAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54340	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TGTCACATTTCCACAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54341	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CAGAAGATTCTAGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54342	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				CAGAAGATTCTAGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54343	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CAGAAGATTCTAGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54344	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCGGGCAATGCACCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54345	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TCGGGCAATGCACCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54346	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TCGGGCAATGCACCTGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54347	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CTTGTGTCTCTCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54348	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				CTTGTGTCTCTCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54349	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				CTTGTGTCTCTCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54350	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTACCTACCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54351	hg19	N/A	enh5746	fant7983	Enhatls100135	enhancer	E_603				TTACCTACCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-93502	chr2	102367260	102382067	101750798	101765605	54352	hg19	N/A	enh5746	N/A	Enhatls100135	enhancer	E_603				TTACCTACCACACCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MAP4K4	direct	Highly Significant	NA					MAP4K4	chr2	101696849	101894690	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5428
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54353	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				ATGACAGCTTAAGCACGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54354	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				ATGACAGCTTAAGCACGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54355	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				ATGACAGCTTAAGCACGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54356	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				ATGACAGCTTAAGCACGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54357	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GCTGCGCCGACGACGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54358	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GCTGCGCCGACGACGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54359	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GCTGCGCCGACGACGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54360	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GCTGCGCCGACGACGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54361	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TTAGAGTCTATCTACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54362	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TTAGAGTCTATCTACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54363	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TTAGAGTCTATCTACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54364	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TTAGAGTCTATCTACCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	direct	Highly Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54365	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TGTAATGCACTTTCGCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54366	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TGTAATGCACTTTCGCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54367	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TGTAATGCACTTTCGCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54368	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TGTAATGCACTTTCGCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54369	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TGGAGCGTCTCGCACGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54370	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TGGAGCGTCTCGCACGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54371	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TGGAGCGTCTCGCACGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54372	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TGGAGCGTCTCGCACGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54373	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				AGGGGCTGGCGCGGATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54374	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				AGGGGCTGGCGCGGATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54375	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				AGGGGCTGGCGCGGATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54376	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				AGGGGCTGGCGCGGATTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54377	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GCTGGTCCGCAGCCTTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54378	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GCTGGTCCGCAGCCTTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54379	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GCTGGTCCGCAGCCTTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54380	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GCTGGTCCGCAGCCTTCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54381	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TCTGCGTGACTGACTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54382	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TCTGCGTGACTGACTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54383	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TCTGCGTGACTGACTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54384	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TCTGCGTGACTGACTAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54385	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				ACAGGGGTGGGTGTGAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54386	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				ACAGGGGTGGGTGTGAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54387	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				ACAGGGGTGGGTGTGAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54388	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				ACAGGGGTGGGTGTGAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54389	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TATCCTGGACCTAGAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54390	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TATCCTGGACCTAGAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54391	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TATCCTGGACCTAGAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54392	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TATCCTGGACCTAGAGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54393	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GTACCAGGCGCGCCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54394	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GTACCAGGCGCGCCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54395	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GTACCAGGCGCGCCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54396	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GTACCAGGCGCGCCCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54397	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				AACGCGGGAAGTGAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54398	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				AACGCGGGAAGTGAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54399	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				AACGCGGGAAGTGAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54400	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				AACGCGGGAAGTGAAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54401	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GTCGGCCGCGACCCCCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54402	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GTCGGCCGCGACCCCCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54403	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GTCGGCCGCGACCCCCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54404	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GTCGGCCGCGACCCCCCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54405	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GCGCCGGACGCCGGCGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54406	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GCGCCGGACGCCGGCGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54407	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GCGCCGGACGCCGGCGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54408	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GCGCCGGACGCCGGCGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54409	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GCCGCTGACGCGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54410	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GCCGCTGACGCGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54411	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GCCGCTGACGCGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54412	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GCCGCTGACGCGCTTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54413	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GCGGCAGGTTATTTATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54414	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GCGGCAGGTTATTTATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54415	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GCGGCAGGTTATTTATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54416	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GCGGCAGGTTATTTATAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54417	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GTGACGCTGGGGCGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54418	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GTGACGCTGGGGCGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54419	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GTGACGCTGGGGCGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54420	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GTGACGCTGGGGCGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54421	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				AGCTCGACGCGAAGGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54422	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				AGCTCGACGCGAAGGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54423	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				AGCTCGACGCGAAGGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54424	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				AGCTCGACGCGAAGGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54425	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				GTTCCCTCCTCGCCATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54426	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				GTTCCCTCCTCGCCATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54427	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				GTTCCCTCCTCGCCATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54428	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				GTTCCCTCCTCGCCATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54429	hg19	N/A	enh69950	N/A	Enhatls102733	enhancer	E_604				TCACACACCTATTCTAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54430	hg19	N/A	enh69950	fant9000	Enhatls102733	enhancer	E_604				TCACACACCTATTCTAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54431	hg19	N/A	N/A	fant9000	Enhatls102733	enhancer	E_604				TCACACACCTATTCTAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-95965	chr2	157195270	157200088	156338758	156343576	54432	hg19	N/A	N/A	N/A	Enhatls102733	enhancer	E_604				TCACACACCTATTCTAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NR4A2	indirect	Non Significant	NA					NR4A2	chr2	156324436	156342348	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7891
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54433	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				GAAACAACCAGCATGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54434	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				GAAACAACCAGCATGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54435	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				ATACCAGTGGTTTGCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54436	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				ATACCAGTGGTTTGCCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54437	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TGAGATTTTGGGGCTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54438	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TGAGATTTTGGGGCTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54439	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TATTGACTCACAGGATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54440	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TATTGACTCACAGGATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54441	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TAAGCAGACTGTATTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54442	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TAAGCAGACTGTATTAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54443	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TTTCTATTGGACAACTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54444	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TTTCTATTGGACAACTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54445	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TTTCGAGTTTCAAGACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54446	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TTTCGAGTTTCAAGACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54447	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				GGAAGCTGACTCACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54448	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				GGAAGCTGACTCACAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54449	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				AAGAAATTAGGGAGGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54450	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				AAGAAATTAGGGAGGGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54451	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TTATTCGGGTGATGTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54452	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TTATTCGGGTGATGTCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54453	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				CTTCCTGTGCCAGTAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54454	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				CTTCCTGTGCCAGTAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54455	hg19	N/A	enh34216	N/A	Enhatls106289	enhancer	E_605				TCTCCAACAGTATACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-99354	chr2	212916452	212919807	212051727	212055082	54456	hg19	N/A	N/A	N/A	Enhatls106289	enhancer	E_605				TCTCCAACAGTATACAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ERBB4	direct	Highly Significant	NA					ERBB4	chr2	211375716	212538841	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	11280
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54457	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				AGGCGCTCACCCCACTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54458	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				AGGCGCTCACCCCACTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54459	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				AGGCGCTCACCCCACTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54460	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TTAAGTACCTGAATATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54461	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				TTAAGTACCTGAATATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54462	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TTAAGTACCTGAATATGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54463	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TCTGAGATATACTCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54464	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				TCTGAGATATACTCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54465	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TCTGAGATATACTCTCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54466	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCCACAGAAGATGACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54467	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				GCCACAGAAGATGACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54468	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCCACAGAAGATGACAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54469	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCTTTTGGCTGTGCTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54470	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				GCTTTTGGCTGTGCTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54471	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCTTTTGGCTGTGCTATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54472	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCAATTCCTTCAGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54473	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				GCAATTCCTTCAGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54474	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GCAATTCCTTCAGGCTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54475	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				AATGGCTATAAATCGCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54476	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				AATGGCTATAAATCGCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54477	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				AATGGCTATAAATCGCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54478	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TTCTGCGGATGCTTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54479	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				TTCTGCGGATGCTTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54480	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TTCTGCGGATGCTTCTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54481	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TCTGAAAGCCCAACACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54482	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				TCTGAAAGCCCAACACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54483	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				TCTGAAAGCCCAACACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54484	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GGGTAGGTGTGGGGTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54485	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				GGGTAGGTGTGGGGTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54486	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GGGTAGGTGTGGGGTCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54487	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				CCGGGTTACCAGTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54488	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				CCGGGTTACCAGTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54489	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				CCGGGTTACCAGTAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54490	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GAAGCCGCAGTGGCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54491	hg19	N/A	enh19325	fant10550	Enhatls107632	enhancer	E_606				GAAGCCGCAGTGGCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100606	chr2	233179650	233182446	232314940	232317736	54492	hg19	N/A	enh19325	N/A	Enhatls107632	enhancer	E_606				GAAGCCGCAGTGGCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					DIS3L2	chr2	231961244	232344350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12532
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54493	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54494	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54495	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54496	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54497	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54498	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				CGATAAAGAATTGTATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54499	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54500	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54501	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54502	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54503	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54504	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TCGAGGTATTGAGAATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54505	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54506	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54507	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54508	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54509	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54510	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTTTCCAGTTATGAAACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54511	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54512	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54513	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54514	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54515	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54516	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTCAAGCTTCATCTGTGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54517	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54518	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54519	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54520	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54521	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54522	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				ATGTGGTTCTTTCAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	direct	Highly Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54523	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54524	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54525	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54526	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54527	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54528	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				GTGATGAACATTCATATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54529	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54530	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54531	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54532	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54533	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54534	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				CATTTAAGTCTAACACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54535	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54536	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54537	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54538	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54539	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54540	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TGGTAGGGAAGTGGAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54541	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54542	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54543	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54544	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54545	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54546	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				TGTGAAGTGATGTCTTATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54547	hg19	N/A	N/A	N/A	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54548	hg19	N/A	N/A	fant10570	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54549	hg19	N/A	enh6210	fant10570	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54550	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54551	hg19	N/A	enh6210	fant10571	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-100714	chr2	233923627	233934170	233058917	233069460	54552	hg19	N/A	enh6210	N/A	Enhatls107741	enhancer	E_608				ATGCCAAACGTCTTTTCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NGEF	indirect	Non Significant	NA					INPP5D	chr2	233059966	233207903	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12640
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54553	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				ATGCTGCGTTCGTCCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54554	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				AGATTCCCATACTCTGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54555	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				TCCTAGAGCAAGCAAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54556	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				TTGGAGAATACATCATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54557	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				AAGCAGCCTCCACCCTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54558	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				ACAAACTGACTTGACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54559	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				GCAAAGGTGGAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54560	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				ACTTGACCTATAAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54561	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				GTGTGGACATCGGTGTCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238367403	238370331	237458760	237461688	54562	hg19	N/A	enh19393	N/A	Enhatls108066	enhancer	E_610				GAGTCAGTGTAGCTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					COL6A3	chr2	237324017	237414207	13356				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54563	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CCCCAAAGCAAGAGTAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54564	hg19	N/A	enh19394	fant10769	Enhatls108066	enhancer	E_611				CCCCAAAGCAAGAGTAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54565	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CCCCAAAGCAAGAGTAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	16612				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54566	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CTACCAACTGAGTCACGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54567	hg19	N/A	enh19394	fant10769	Enhatls108066	enhancer	E_611				CTACCAACTGAGTCACGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54568	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CTACCAACTGAGTCACGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	16612				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54569	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				ATGGCGAGCAATTATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54570	hg19	N/A	enh19394	fant10769	Enhatls108066	enhancer	E_611				ATGGCGAGCAATTATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54571	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				ATGGCGAGCAATTATTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	16612				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54572	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CCCACTCCCGTGGCCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54573	hg19	N/A	enh19394	fant10769	Enhatls108066	enhancer	E_611				CCCACTCCCGTGGCCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54574	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CCCACTCCCGTGGCCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	16612				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54575	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CAGGGTTGCTGCTGATCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54576	hg19	N/A	enh19394	fant10769	Enhatls108066	enhancer	E_611				CAGGGTTGCTGCTGATCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	19550				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238373654	238376680	237465011	237468037	54577	hg19	N/A	enh19394	N/A	Enhatls108066	enhancer	E_611				CAGGGTTGCTGCTGATCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	16612				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54578	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54579	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54580	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54581	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54582	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54583	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54584	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TTGATACTAAACACACAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54585	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54586	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54587	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54588	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54589	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54590	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54591	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				TGGATGGAGGGGCCCAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54592	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54593	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54594	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54595	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54596	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54597	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54598	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CTTTGAATCCCACAAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54599	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54600	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54601	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54602	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54603	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54604	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54605	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTTCGGGGTAAAGGTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54606	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54607	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54608	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54609	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54610	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54611	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54612	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GCTCCCGGCAACATGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54613	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54614	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54615	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54616	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54617	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54618	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54619	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTCCGGGGACGGCAGACGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54620	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54621	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54622	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54623	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54624	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54625	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54626	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				ACCCTCCCGAAGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54627	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54628	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54629	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54630	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54631	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54632	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54633	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CCTGCTTGTAGGGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54634	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54635	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54636	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54637	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54638	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54639	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54640	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				CGTGACTCCTCCGCTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54641	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54642	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54643	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54644	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54645	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54646	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54647	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GAGGCCGTACGTCAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54648	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54649	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54650	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54651	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54652	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54653	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54654	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AAGGTAGTAGACCCAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54655	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54656	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54657	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54658	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54659	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54660	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54661	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTGTGTCAACACCTCTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54662	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54663	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54664	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54665	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54666	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54667	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54668	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				AGTGCCGGCGTATTCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54669	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11405				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54670	hg19	N/A	enh19395	fant10770	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	11060				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54671	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10932				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54672	hg19	N/A	enh19395	fant10771	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	10715				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54673	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9624				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54674	hg19	N/A	enh19395	fant10772	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	9061				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101029	chr2	238378358	238385792	237469715	237477149	54675	hg19	N/A	enh19395	N/A	Enhatls108066	enhancer	E_612				GTACGGTCCCCACTTCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					MLPH	chr2	237485427	237555322	6774				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12955
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54676	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				GTGGCCTGTTAGGACAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54677	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				CAGAACGGACGGGAGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54678	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				CACGTTGGCTTTCCAGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54679	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				GCAGGACATGACACAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54680	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				ACCTGAGTCAATCCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54681	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				TGGTGACCTTAAGCCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54682	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				AGGGAAAAAATCCAGACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54683	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				CTTGGCTGCAGGATCCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54684	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				TCCAGGGGAGAGGGTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54685	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				CCACACGTGACAAAAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101050	chr2	238490601	238491724	237581958	237583081	54686	hg19	N/A	enh53634	N/A	Enhatls108088	enhancer	E_613				ATATTGCCACTTTTAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12976
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54687	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54688	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54689	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54690	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54691	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54692	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54693	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54694	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GCTAGCGCTGCCTGCACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54695	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54696	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54697	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54698	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54699	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54700	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54701	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54702	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TGACCGGCTCCTGCACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54703	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54704	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54705	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54706	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54707	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54708	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54709	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54710	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				CAGACAGTCTCAGCAACGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54711	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54712	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54713	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54714	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54715	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54716	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54717	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54718	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGAAGCATCTAGAACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54719	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54720	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54721	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54722	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54723	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54724	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54725	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54726	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				TTCATTGTGTGTGTTGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54727	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54728	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54729	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54730	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54731	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54732	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54733	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54734	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GTGGGGGTTGGAATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54735	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54736	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54737	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54738	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54739	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54740	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54741	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54742	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AAGGAAGTTGAAATAGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54743	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54744	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54745	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54746	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54747	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54748	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54749	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54750	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGTTCTTAGTGGGCCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54751	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54752	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54753	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54754	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54755	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54756	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54757	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54758	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				GGGAGCCTGAGGCGAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101051	chr2	238498314	238514275	237589671	237605632	54759	hg19	N/A	N/A	N/A	Enhatls108089	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12977
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54760	hg19	N/A	enh19398	N/A	N/A	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	1276				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54761	hg19	N/A	enh19398	N/A	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	5348				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54762	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	8293				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54763	hg19	N/A	N/A	fant10782	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9400				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54764	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	9700				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54765	hg19	N/A	N/A	fant10783	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	12816				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101052	chr2	238498314	238514275	237589671	237605632	54766	hg19	N/A	N/A	N/A	Enhatls108090	enhancer	E_614				AGCTAATTAAAAAAAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAB17	chr2	237574325	237590780	13516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12978
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54767	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				AGTTAGGCTAATCCGTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54768	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				AGTTAGGCTAATCCGTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54769	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				AGTTAGGCTAATCCGTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54770	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				AGTTAGGCTAATCCGTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54771	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				AGTTAGGCTAATCCGTGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54772	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGCTCTAAGTCACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54773	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GGCTCTAAGTCACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54774	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGCTCTAAGTCACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54775	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GGCTCTAAGTCACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54776	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGCTCTAAGTCACCACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54777	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				ACAGCGCTGGGAGGGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54778	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				ACAGCGCTGGGAGGGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54779	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				ACAGCGCTGGGAGGGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54780	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				ACAGCGCTGGGAGGGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54781	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				ACAGCGCTGGGAGGGCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54782	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGTGACGTCCAGACTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54783	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GGTGACGTCCAGACTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54784	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGTGACGTCCAGACTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54785	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GGTGACGTCCAGACTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54786	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGTGACGTCCAGACTCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54787	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGGTCTCGCCAAGAGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54788	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GGGTCTCGCCAAGAGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54789	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGGTCTCGCCAAGAGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54790	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GGGTCTCGCCAAGAGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54791	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGGTCTCGCCAAGAGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54792	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GCGGCACTGGATGTACAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54793	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GCGGCACTGGATGTACAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54794	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GCGGCACTGGATGTACAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54795	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GCGGCACTGGATGTACAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54796	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GCGGCACTGGATGTACAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54797	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GACAACCGCACACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54798	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GACAACCGCACACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54799	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GACAACCGCACACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54800	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GACAACCGCACACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54801	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GACAACCGCACACCCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54802	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CAGACAGAACGACCGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54803	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				CAGACAGAACGACCGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54804	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CAGACAGAACGACCGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54805	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				CAGACAGAACGACCGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54806	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CAGACAGAACGACCGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54807	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGACAATTCAGATCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54808	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GGACAATTCAGATCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54809	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGACAATTCAGATCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54810	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GGACAATTCAGATCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54811	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GGACAATTCAGATCATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54812	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GAAGCTGACTCGATGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54813	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GAAGCTGACTCGATGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54814	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GAAGCTGACTCGATGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54815	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GAAGCTGACTCGATGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54816	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GAAGCTGACTCGATGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54817	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGGGCGTTTCCTGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54818	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GTGGGCGTTTCCTGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54819	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGGGCGTTTCCTGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54820	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GTGGGCGTTTCCTGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54821	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGGGCGTTTCCTGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54822	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGCCCAGACTCATGTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54823	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				GTGCCCAGACTCATGTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54824	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGCCCAGACTCATGTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54825	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				GTGCCCAGACTCATGTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54826	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				GTGCCCAGACTCATGTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54827	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CCTGCATTTCCTTCCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54828	hg19	N/A	enh19400	fant10788	Enhatls108091	enhancer	E_615				CCTGCATTTCCTTCCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54829	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CCTGCATTTCCTTCCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54830	hg19	N/A	enh19400	fant10789	Enhatls108091	enhancer	E_615				CCTGCATTTCCTTCCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238581885	238582905	237673242	237674262	54831	hg19	N/A	enh19400	N/A	Enhatls108091	enhancer	E_615				CCTGCATTTCCTTCCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54832	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GGTGTACCCAGGCTGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54833	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				GGTGTACCCAGGCTGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54834	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GGTGTACCCAGGCTGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54835	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GAAGAATCGCACAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54836	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				GAAGAATCGCACAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54837	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GAAGAATCGCACAAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54838	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				TTCACTCACGTGAATGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54839	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				TTCACTCACGTGAATGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54840	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				TTCACTCACGTGAATGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54841	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				TAGACTGGTGATGTATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54842	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				TAGACTGGTGATGTATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54843	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				TAGACTGGTGATGTATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54844	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CTCTGCTTGACGCTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54845	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				CTCTGCTTGACGCTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54846	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CTCTGCTTGACGCTAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54847	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GATGGAAATGACGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54848	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				GATGGAAATGACGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54849	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GATGGAAATGACGCCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54850	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				AACAGGCTCCTGGCAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54851	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				AACAGGCTCCTGGCAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54852	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				AACAGGCTCCTGGCAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54853	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GTATGCCCTGGGTCTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54854	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				GTATGCCCTGGGTCTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54855	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GTATGCCCTGGGTCTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54856	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GCCTTCTCAGCCTGGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54857	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				GCCTTCTCAGCCTGGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54858	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				GCCTTCTCAGCCTGGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54859	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				AACTGCCTGCCCTAAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54860	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				AACTGCCTGCCCTAAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54861	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				AACTGCCTGCCCTAAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54862	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CAGGATCCCCTGAAGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54863	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				CAGGATCCCCTGAAGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54864	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CAGGATCCCCTGAAGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54865	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				ACTGCTGGCAAAGGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54866	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				ACTGCTGGCAAAGGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54867	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				ACTGCTGGCAAAGGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54868	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CCTACCAGAAGATCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54869	hg19	N/A	enh19401	fant10797	Enhatls108092	enhancer	E_616				CCTACCAGAAGATCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101053	chr2	238608500	238610985	237699857	237702342	54870	hg19	N/A	enh19401	N/A	Enhatls108092	enhancer	E_616				CCTACCAGAAGATCATCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					LRRFIP1	chr2	237627586	237781643	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	12979
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54871	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				ACAGGAGTCTATGCAAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54872	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				ACAGGAGTCTATGCAAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54873	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				ACAGGAGTCTATGCAAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54874	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				ACAGGAGTCTATGCAAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54875	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GAGGTGTTTCTGGCGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54876	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GAGGTGTTTCTGGCGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54877	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GAGGTGTTTCTGGCGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54878	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GAGGTGTTTCTGGCGGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54879	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GGAGGGGTGACCGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54880	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GGAGGGGTGACCGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54881	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GGAGGGGTGACCGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54882	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GGAGGGGTGACCGGTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54883	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				AATCATGTCAAGGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54884	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				AATCATGTCAAGGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54885	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				AATCATGTCAAGGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54886	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				AATCATGTCAAGGTGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54887	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TTAGAACCATAAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54888	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TTAGAACCATAAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54889	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TTAGAACCATAAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54890	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TTAGAACCATAAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54891	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				ATCAATGGCTCAATATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54892	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				ATCAATGGCTCAATATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54893	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				ATCAATGGCTCAATATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54894	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				ATCAATGGCTCAATATTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54895	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				CCTGGATGCAGACGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54896	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				CCTGGATGCAGACGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54897	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				CCTGGATGCAGACGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54898	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				CCTGGATGCAGACGTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54899	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TTTTCTAGCTGGTCATCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54900	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TTTTCTAGCTGGTCATCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54901	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TTTTCTAGCTGGTCATCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54902	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TTTTCTAGCTGGTCATCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54903	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TAAAATAAAAAACAGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54904	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TAAAATAAAAAACAGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54905	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TAAAATAAAAAACAGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54906	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TAAAATAAAAAACAGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54907	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				CATAAGGTCACCCGTAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54908	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				CATAAGGTCACCCGTAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54909	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				CATAAGGTCACCCGTAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54910	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				CATAAGGTCACCCGTAACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54911	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				CCATCGCCAGCAGCAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54912	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				CCATCGCCAGCAGCAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54913	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				CCATCGCCAGCAGCAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54914	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				CCATCGCCAGCAGCAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54915	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TGGGGCGCCGAACCCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54916	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TGGGGCGCCGAACCCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54917	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TGGGGCGCCGAACCCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54918	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TGGGGCGCCGAACCCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54919	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				CACAGATAATGTTATCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54920	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				CACAGATAATGTTATCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54921	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				CACAGATAATGTTATCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54922	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				CACAGATAATGTTATCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54923	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TACTACAGCCTGGGCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54924	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TACTACAGCCTGGGCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54925	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TACTACAGCCTGGGCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54926	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TACTACAGCCTGGGCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54927	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				CAGAATGGCTCTAAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54928	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				CAGAATGGCTCTAAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54929	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				CAGAATGGCTCTAAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54930	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				CAGAATGGCTCTAAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54931	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TGGTCCGGTGGCCTTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54932	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TGGTCCGGTGGCCTTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54933	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TGGTCCGGTGGCCTTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54934	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TGGTCCGGTGGCCTTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54935	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				ACAGGGGATTGCATGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54936	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				ACAGGGGATTGCATGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54937	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				ACAGGGGATTGCATGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54938	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				ACAGGGGATTGCATGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54939	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GGGGCCAGAAACAATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54940	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GGGGCCAGAAACAATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54941	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GGGGCCAGAAACAATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54942	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GGGGCCAGAAACAATGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54943	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GGCCGAGCTGCTCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54944	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GGCCGAGCTGCTCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54945	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GGCCGAGCTGCTCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54946	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GGCCGAGCTGCTCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54947	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GCAGTGGAGGATCTGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54948	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GCAGTGGAGGATCTGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54949	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GCAGTGGAGGATCTGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54950	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GCAGTGGAGGATCTGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54951	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GCAGCCAAGGATCCCGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54952	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GCAGCCAAGGATCCCGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54953	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GCAGCCAAGGATCCCGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54954	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GCAGCCAAGGATCCCGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54955	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TGCAGACTCCCCTCCTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54956	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TGCAGACTCCCCTCCTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54957	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TGCAGACTCCCCTCCTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54958	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TGCAGACTCCCCTCCTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54959	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				ACTCCAGGCAGGATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54960	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				ACTCCAGGCAGGATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54961	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				ACTCCAGGCAGGATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54962	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				ACTCCAGGCAGGATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54963	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GGTGCCAGCGTGAGTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54964	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GGTGCCAGCGTGAGTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54965	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GGTGCCAGCGTGAGTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54966	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GGTGCCAGCGTGAGTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54967	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				TAAGGGGGCAGGCTTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54968	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				TAAGGGGGCAGGCTTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54969	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				TAAGGGGGCAGGCTTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54970	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				TAAGGGGGCAGGCTTCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54971	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GAGCAGTGAGGGATAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54972	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GAGCAGTGAGGGATAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54973	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GAGCAGTGAGGGATAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54974	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GAGCAGTGAGGGATAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54975	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				GACACTGACTTGTCAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54976	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				GACACTGACTTGTCAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54977	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				GACACTGACTTGTCAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54978	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				GACACTGACTTGTCAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54979	hg19	N/A	enh34438	N/A	N/A	enhancer	E_617				AGTAGGTGGGCTTTCCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54980	hg19	N/A	enh34438	N/A	Enhatls108127	enhancer	E_617				AGTAGGTGGGCTTTCCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101083	chr2	238767540	238787711	237858897	237879069	54981	hg19	N/A	N/A	N/A	Enhatls108127	enhancer	E_617				AGTAGGTGGGCTTTCCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13009
enhrx-101084	chr2	238767540	238787711	237858897	237879069	54982	hg19	N/A	N/A	N/A	Enhatls108128	enhancer	E_617				AGTAGGTGGGCTTTCCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54983	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54984	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54985	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54986	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54987	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54988	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54989	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TGCAAATGAATATGTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54990	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54991	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54992	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54993	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54994	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54995	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54996	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAAATGTGTAGGCATCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54997	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54998	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	54999	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55000	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55001	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55002	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55003	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGAGAGTACAATCAAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55004	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55005	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55006	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55007	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55008	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55009	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55010	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GGGACTGGCAGCACGCGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55011	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55012	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55013	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55014	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55015	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55016	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55017	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GTGCACACCTGGAACTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55018	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55019	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55020	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55021	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55022	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55023	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55024	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TGACACTGGGGAAATGTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55025	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55026	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55027	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55028	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55029	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55030	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55031	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GAGCTCACACACGCAGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55032	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55033	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55034	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55035	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55036	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55037	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55038	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				TCAGGTGTGGAGCAAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55039	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55040	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55041	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55042	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55043	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55044	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55045	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GCGTGGCTCTCTGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55046	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55047	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55048	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55049	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55050	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55051	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55052	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				GGTGTGAGCCCTGACACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55053	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55054	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55055	hg19	hs1968	enh19403	fant10799	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55056	hg19	hs1968	enh19403	N/A	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55057	hg19	hs1968	enh19403	fant10800	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55058	hg19	N/A	enh19403	fant10800	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101084	chr2	238801636	238808633	237892994	237899991	55059	hg19	N/A	enh19403	N/A	Enhatls108128	enhancer	E_618				CATTTAGGACTGGAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					RAMP1	chr2	237858892	237912106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13010
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55060	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				AGGTTAGTTCAAGTTTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55061	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				AATGGGAGACAGTGTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55062	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				AAAAAGCCCCCAGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55063	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				ATAGGGACATGGTAGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55064	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				CATGCACAGACCTTATTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55065	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				TGTGATGGCTTTGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101085	chr2	238866181	238870396	237957539	237961754	55066	hg19	N/A	N/A	N/A	Enhatls108129	enhancer	E_619				AAACAAGCTGTATTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	5142				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13011
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55067	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				AATGGGCGCGGGATGAATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55068	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				ACACGGTTTGGGGTTGGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55069	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GCTATCCTTCCCTGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55070	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GGTTCACTTCGTGGTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55071	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				TCTGGAGCCCGAGCGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55072	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				CGCTACTCGCCAATCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55073	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GGAACCAGACACGCGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55074	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				ACAGCCGCACCGGCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55075	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GCGACCGTGCGGCTCTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55076	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				CCCCGGCGTGAGGAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55077	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GCGTGAATGGGAAGGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55078	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				CGCCCGGCAGTGAGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101086	chr2	238874882	238877317	237966240	237968675	55079	hg19	N/A	N/A	fant10804	N/A	enhancer	E_620				GTCTGTGCCACGCTCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					UBE2F	chr2	237966954	238042782	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13012
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55080	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55081	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55082	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55083	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55084	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55085	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				GCTCTGGAGGCCCCCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55086	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55087	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55088	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55089	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55090	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55091	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				GCTGACGCCAAGGAGATGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55092	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55093	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55094	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55095	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55096	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55097	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				GGGGGTTTGGGGCTGACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55098	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55099	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55100	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55101	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55102	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55103	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				GGGGTTGCCCAGCCGTCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55104	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55105	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55106	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55107	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55108	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55109	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				AGTAAACAGAGTCTTCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55110	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55111	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55112	hg19	N/A	enh86403	fant10807	Enhatls108162	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55113	hg19	N/A	enh86403	N/A	Enhatls108162	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55114	hg19	N/A	enh86403	N/A	N/A	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101118	chr2	239049682	239052950	238141041	238144309	55115	hg19	N/A	enh86403	N/A	Enhatls108163	enhancer	E_621				TCCAAAATATGTCCATTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					KLHL30	chr2	238138667	238152947	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13044
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55116	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TTTAAAGATAAGACATAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55117	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TTTAAAGATAAGACATAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55118	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TCACAAGTAAGGTTTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55119	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TCACAAGTAAGGTTTGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55120	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TCATTAGGGGATGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55121	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TCATTAGGGGATGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55122	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				CCAGTCCTGGGACCCGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55123	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				CCAGTCCTGGGACCCGGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55124	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				AGGTTGGCCACTTAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55125	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				AGGTTGGCCACTTAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55126	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				CAGCCACAGTCCTCGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55127	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				CAGCCACAGTCCTCGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55128	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				GGTCCATTCACTGTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55129	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				GGTCCATTCACTGTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55130	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TCCTTCTTGCCCCCAAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55131	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TCCTTCTTGCCCCCAAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55132	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				GGAAGCACTCGCATGAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55133	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				GGAAGCACTCGCATGAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55134	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TTGTGCGACTGCACATACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55135	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TTGTGCGACTGCACATACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55136	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				CTTCATGAAATAATACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55137	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				CTTCATGAAATAATACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55138	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				GCCAGGTAGTGTGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55139	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				GCCAGGTAGTGTGTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	indirect	Non Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55140	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				GAACACCTGGCAGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55141	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				GAACACCTGGCAGTGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55142	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				AAGGGGCCTGAGAACCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55143	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				AAGGGGCCTGAGAACCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55144	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				GAAGGCCACATTGCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55145	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				GAAGGCCACATTGCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55146	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				ATCCTTCCGGGGGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55147	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				ATCCTTCCGGGGGCTCTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55148	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				CAGACGCCTTCCTTCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55149	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				CAGACGCCTTCCTTCATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55150	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TTGCCACGTCACCGACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55151	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TTGCCACGTCACCGACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55152	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				AGTCCAGTGGTGTCCAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55153	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				AGTCCAGTGGTGTCCAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55154	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				CTGTTCCACTTCAGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55155	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				CTGTTCCACTTCAGATCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55156	hg19	N/A	N/A	N/A	Enhatls108232	enhancer	E_622				TCAGAATCTAATGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	44205				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101191	chr2	239406211	239415155	238497570	238506514	55157	hg19	N/A	enh34442	N/A	Enhatls108232	enhancer	E_622				TCAGAATCTAATGATCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					ASB1	chr2	238426926	238452250	46015				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13117
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55158	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GCTTTCATCGATGTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55159	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				GCTTTCATCGATGTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55160	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GCTTTCATCGATGTCTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55161	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GTGTGGTTAACCTCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55162	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				GTGTGGTTAACCTCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55163	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GTGTGGTTAACCTCACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55164	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CTAGAAATCCTCAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55165	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				CTAGAAATCCTCAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55166	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CTAGAAATCCTCAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55167	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GGAGACCAACACTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55168	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				GGAGACCAACACTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55169	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GGAGACCAACACTTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55170	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TTCTATCTCTGACTCATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55171	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				TTCTATCTCTGACTCATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55172	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TTCTATCTCTGACTCATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55173	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TCACACCATGACCACATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55174	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				TCACACCATGACCACATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55175	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TCACACCATGACCACATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55176	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CATCCTTTACCACAGCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55177	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				CATCCTTTACCACAGCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55178	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CATCCTTTACCACAGCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55179	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TTTGTTGAGTTTTAAAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55180	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				TTTGTTGAGTTTTAAAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55181	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				TTTGTTGAGTTTTAAAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55182	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GACATTCTGATCCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55183	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				GACATTCTGATCCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55184	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				GACATTCTGATCCCTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55185	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CTAGCCTTATCCACACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55186	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				CTAGCCTTATCCACACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55187	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CTAGCCTTATCCACACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55188	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CAGTGAGCTAGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	25516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55189	hg19	N/A	enh34445	fant10833	Enhatls108246	enhancer	E_623				CAGTGAGCTAGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38221				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239868344	239871825	238946648	238950129	55190	hg19	N/A	enh34445	N/A	Enhatls108246	enhancer	E_623				CAGTGAGCTAGCCTCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	38518				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55191	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				GGTTGGGCTAGGGCAAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55192	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				GCAGTAACCCCAGAAGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55193	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				ATGAGTAATGGCAGTTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55194	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				TTTATTATGATAGCAGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55195	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				GGAAAGAAATATCCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55196	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				TGGGGCCTGAGGCATCGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55197	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				GAAGCATTGCCCCCTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101202	chr2	239892997	239897148	238971301	238975452	55198	hg19	N/A	enh34446	N/A	Enhatls108246	enhancer	E_624				ATCCCGAGTACAAACCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	UBE2F	direct	Highly Significant	NA					TWIST2	chr2	238848031	238910534	58036				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13128
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55199	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55200	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55201	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55202	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55203	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55204	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55205	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55206	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGGCACAGTGTTGGTAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55207	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55208	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55209	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55210	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55211	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55212	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55213	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55214	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCAGGGCCTGGACACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55215	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55216	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55217	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55218	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55219	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55220	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55221	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55222	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				ACGTACACTGGGCAGGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55223	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55224	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55225	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55226	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55227	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55228	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55229	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55230	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				AGTCCCCGACCAACAACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55231	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55232	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55233	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55234	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55235	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55236	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55237	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55238	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CCCAAGATCACTTATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55239	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55240	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55241	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55242	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55243	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55244	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55245	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55246	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CCAGCTTTGCCGTGATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55247	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55248	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55249	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55250	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55251	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55252	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55253	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55254	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACCAGCTGTGTCTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55255	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55256	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55257	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55258	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55259	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55260	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55261	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55262	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGATCCAAAAATAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55263	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55264	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55265	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55266	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55267	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55268	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55269	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55270	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				ACAGACAGCTGAGCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55271	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55272	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55273	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55274	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55275	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55276	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55277	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55278	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				TTACAGGCCCATCCCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55279	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55280	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55281	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55282	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55283	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55284	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55285	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55286	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				CAGGCACCCGAGGGTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55287	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65575				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55288	hg19	hs1937	enh19420	fant10896	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	65135				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55289	hg19	hs1937	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55290	hg19	hs1937	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	62086				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55291	hg19	N/A	enh19420	fant10897	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61926				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55292	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	61465				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55293	hg19	N/A	enh19420	fant10898	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	60898				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101247	chr2	241308956	241315777	240369539	240376360	55294	hg19	N/A	enh19420	N/A	Enhatls108295	enhancer	E_625				GGACAGCCACGGCCCTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					GPC1	chr2	240435662	240468076	56005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13173
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55295	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				ACAGGGCGGGCGCCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55296	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				ACAGGGCGGGCGCCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55297	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				ACAGGGCGGGCGCCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55298	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				ACAGGGCGGGCGCCACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55299	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				GGACTGTGTGAGGAACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55300	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				GGACTGTGTGAGGAACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55301	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				GGACTGTGTGAGGAACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55302	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				GGACTGTGTGAGGAACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55303	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				GAGCAGCCGTAGGCGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55304	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				GAGCAGCCGTAGGCGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55305	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				GAGCAGCCGTAGGCGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55306	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				GAGCAGCCGTAGGCGTGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55307	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				CAGCCCTCTCCATGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55308	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				CAGCCCTCTCCATGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55309	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				CAGCCCTCTCCATGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55310	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				CAGCCCTCTCCATGTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55311	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				TCCGGGGCGGCCTCACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55312	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				TCCGGGGCGGCCTCACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55313	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				TCCGGGGCGGCCTCACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55314	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				TCCGGGGCGGCCTCACGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55315	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				CGTGGGGGTGGATCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55316	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				CGTGGGGGTGGATCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55317	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				CGTGGGGGTGGATCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55318	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				CGTGGGGGTGGATCCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55319	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				CCGCCCCGCCCCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55320	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				CCGCCCCGCCCCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55321	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				CCGCCCCGCCCCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55322	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				CCGCCCCGCCCCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55323	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				GCGAAGCTGGCGCGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55324	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				GCGAAGCTGGCGCGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55325	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				GCGAAGCTGGCGCGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55326	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				GCGAAGCTGGCGCGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55327	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				ACTCAGGCTCTACCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55328	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				ACTCAGGCTCTACCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55329	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				ACTCAGGCTCTACCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55330	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				ACTCAGGCTCTACCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55331	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				CTGCTGCACGGGGCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55332	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				CTGCTGCACGGGGCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55333	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				CTGCTGCACGGGGCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55334	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				CTGCTGCACGGGGCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55335	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				GAGGGTCCCGGGAGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55336	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				GAGGGTCCCGGGAGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55337	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				GAGGGTCCCGGGAGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55338	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				GAGGGTCCCGGGAGAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101339	chr2	241720996	241724475	240781579	240785058	55339	hg19	N/A	N/A	N/A	Enhatls108385	enhancer	E_626				CCCGGAAACGAGGGTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13265
enhrx-101340	chr2	241720996	241724475	240781579	240785058	55340	hg19	N/A	N/A	N/A	Enhatls108386	enhancer	E_626				CCCGGAAACGAGGGTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13266
enhrx-101341	chr2	241720996	241724475	240781579	240785058	55341	hg19	N/A	N/A	N/A	Enhatls108387	enhancer	E_626				CCCGGAAACGAGGGTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13267
enhrx-101342	chr2	241720996	241724475	240781579	240785058	55342	hg19	N/A	N/A	N/A	Enhatls108388	enhancer	E_626				CCCGGAAACGAGGGTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					KIF1A	chr2	240713760	240824293	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13268
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55343	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55344	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55345	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55346	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55347	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55348	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55349	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55350	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCATCTGATCCACTTAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55351	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55352	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55353	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55354	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55355	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55356	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55357	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55358	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTAATGTTCTACTCATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55359	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55360	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55361	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55362	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55363	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55364	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55365	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55366	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTGGGTAGCTTCTGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55367	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55368	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55369	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55370	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55371	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55372	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55373	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55374	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGTGGATGGCTGGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55375	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55376	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55377	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55378	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55379	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55380	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55381	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55382	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTAAGACGGTGCGGTTACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55383	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55384	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55385	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55386	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55387	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55388	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55389	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55390	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ACAGATAAACCTTGCCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55391	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55392	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55393	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55394	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55395	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55396	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55397	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55398	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACACATTTGGTGTTAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55399	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55400	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55401	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55402	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55403	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55404	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55405	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55406	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCCCGCTCTGGATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55407	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55408	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55409	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55410	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55411	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55412	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55413	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55414	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAGTCAGACAGAATACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55415	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55416	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55417	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55418	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55419	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55420	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55421	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55422	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGGCACTGTGTCCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55423	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55424	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55425	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55426	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55427	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55428	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55429	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55430	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GCGTGGGCGCCAGGGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55431	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55432	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55433	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55434	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55435	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55436	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55437	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55438	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCTCAGGTCCGAATCACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55439	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55440	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55441	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55442	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55443	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55444	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55445	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55446	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				ATTGTGTTGGTGGCATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55447	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55448	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55449	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55450	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55451	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55452	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55453	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55454	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TAAATCTAGGCCACCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55455	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55456	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55457	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55458	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55459	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55460	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55461	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55462	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGAGGCATGTTCCCGCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55463	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55464	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55465	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55466	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55467	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55468	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55469	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55470	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTGCCAGGCTCCATTTCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55471	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55472	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55473	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55474	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55475	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55476	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55477	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55478	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CTCCGGCCAAGTCCAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55479	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55480	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55481	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55482	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55483	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55484	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55485	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55486	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AGTCTGGCCTTGCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55487	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55488	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55489	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55490	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55491	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55492	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55493	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55494	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CAAGCAGCTTCCGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55495	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55496	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55497	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55498	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55499	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55500	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55501	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55502	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TCACTGATGAGCCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55503	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55504	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55505	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55506	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55507	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55508	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55509	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55510	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TGCTCTTGAGCAAGTCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55511	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55512	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55513	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55514	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55515	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55516	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55517	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55518	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GGTCAGGGCGTGATAGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55519	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55520	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55521	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55522	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55523	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55524	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55525	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55526	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTGCTGGGGCCCCCATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55527	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55528	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55529	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55530	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55531	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55532	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55533	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55534	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GAGCCCCTACAGCTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55535	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55536	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55537	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55538	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55539	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55540	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55541	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55542	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CACGCAGCTTACTAATCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55543	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55544	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55545	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55546	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55547	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55548	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55549	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55550	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CGGCTCAGCAGGCAAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55551	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55552	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55553	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55554	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55555	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55556	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55557	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55558	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AAGACCCTGGAGGAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55559	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55560	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55561	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55562	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55563	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55564	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55565	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55566	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				TATGCCTGGGCCAAATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55567	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55568	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55569	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55570	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55571	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55572	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55573	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55574	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				CCAAGGATGGCCTAGGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55575	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55576	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55577	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55578	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55579	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55580	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55581	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55582	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				GTTCGGTCTTGGCCCAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55583	hg19	N/A	enh102663	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55584	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55585	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55586	hg19	N/A	enh102664	fant10917	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55587	hg19	N/A	enh102664	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55588	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55589	hg19	N/A	N/A	fant10918	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101366	chr2	241851095	241862802	240911678	240923385	55590	hg19	N/A	N/A	N/A	Enhatls108411	enhancer	E_627				AACCACACTCAATCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13292
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55591	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				AACTGGACCAGGAAGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55592	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				AACTGGACCAGGAAGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55593	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				AACTGGACCAGGAAGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55594	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GCTGAAGGCAGCTAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55595	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GCTGAAGGCAGCTAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55596	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GCTGAAGGCAGCTAGGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55597	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GTGGTTCCCCCAGCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55598	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GTGGTTCCCCCAGCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55599	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GTGGTTCCCCCAGCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55600	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				AGAGGGACAAAGCTCAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55601	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				AGAGGGACAAAGCTCAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55602	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				AGAGGGACAAAGCTCAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55603	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GGACCCTGAAGAGTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55604	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GGACCCTGAAGAGTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55605	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GGACCCTGAAGAGTGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55606	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GCTCTCTGCCGGAGGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55607	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GCTCTCTGCCGGAGGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55608	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GCTCTCTGCCGGAGGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	indirect	Non Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55609	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				AGAAACGGAGTGCCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55610	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				AGAAACGGAGTGCCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55611	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				AGAAACGGAGTGCCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55612	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GAGGGCACGGAATGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55613	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GAGGGCACGGAATGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55614	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GAGGGCACGGAATGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55615	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GGCTCACAGCCGCTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55616	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GGCTCACAGCCGCTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55617	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GGCTCACAGCCGCTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55618	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GCGGCCGTCACGGTGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55619	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GCGGCCGTCACGGTGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55620	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GCGGCCGTCACGGTGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55621	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GGTTGCTATGGAGACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55622	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GGTTGCTATGGAGACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55623	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GGTTGCTATGGAGACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55624	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GTCACTCTGAGCAACGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55625	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GTCACTCTGAGCAACGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55626	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GTCACTCTGAGCAACGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55627	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				ACTGGGACGGGAGGCCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55628	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				ACTGGGACGGGAGGCCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55629	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				ACTGGGACGGGAGGCCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55630	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CCGCATCAGGAGAAATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55631	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CCGCATCAGGAGAAATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55632	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CCGCATCAGGAGAAATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55633	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				AAGAGCCCGGGCCGGAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55634	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				AAGAGCCCGGGCCGGAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55635	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				AAGAGCCCGGGCCGGAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55636	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GAAGGCGTGTCATCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55637	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GAAGGCGTGTCATCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55638	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GAAGGCGTGTCATCACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55639	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CCAGGCGCCTCCACCAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55640	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CCAGGCGCCTCCACCAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55641	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CCAGGCGCCTCCACCAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55642	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CGTGGGCACAGGCAAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55643	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CGTGGGCACAGGCAAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55644	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CGTGGGCACAGGCAAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55645	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GGCGGGGCTGGCCCCGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55646	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GGCGGGGCTGGCCCCGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55647	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GGCGGGGCTGGCCCCGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55648	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				ACGCGGAGCCCCCGACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55649	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				ACGCGGAGCCCCCGACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55650	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				ACGCGGAGCCCCCGACGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55651	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GGGGGACTAGGCTGCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55652	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GGGGGACTAGGCTGCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55653	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GGGGGACTAGGCTGCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55654	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GACGCCGTGCCGCATCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55655	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GACGCCGTGCCGCATCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55656	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GACGCCGTGCCGCATCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55657	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GAACGGGTAGAAGTCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55658	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GAACGGGTAGAAGTCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55659	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GAACGGGTAGAAGTCGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55660	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GTCACCCCCAAGCAGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55661	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GTCACCCCCAAGCAGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55662	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GTCACCCCCAAGCAGGACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55663	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CCGGGCGCCCCGCGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55664	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CCGGGCGCCCCGCGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55665	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CCGGGCGCCCCGCGAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55666	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CGGCGGGAGTCCGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55667	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CGGCGGGAGTCCGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55668	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CGGCGGGAGTCCGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55669	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				CGGCGGCCAAGGCCGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55670	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				CGGCGGCCAAGGCCGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55671	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				CGGCGGCCAAGGCCGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55672	hg19	N/A	enh102665	N/A	Enhatls108420	enhancer	E_628				GCCCCCGCCTCGGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101371	chr2	241925215	241939934	240985798	241000517	55673	hg19	N/A	N/A	N/A	Enhatls108420	enhancer	E_628				GCCCCCGCCTCGGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					CROCC2	chr2	240906329	240993311	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13297
enhrx-101372	chr2	241925215	241939934	240985798	241000517	55674	hg19	N/A	N/A	N/A	Enhatls108421	enhancer	E_628				GCCCCCGCCTCGGTGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55675	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				AGGTGCTCCACCAGTCCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55676	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				CAGGAGCTGCTGTCAACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55677	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				TGAGGGCAGCAAGAGGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55678	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				GGGCATGGCCCCATGGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55679	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				TGCATTCAGCGCCCCCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55680	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				AAGGGGTTGTTCCAGTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55681	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				GCCCCTGGCCCAGCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55682	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				GAGACCATCCCCTTCAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55683	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				CAAGCTTCTAAAACACCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55684	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				AAACGTTAGATCACAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55685	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				ATATCGGCACTTTCAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55686	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				CCTGCCTTTCCTGCAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55687	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				GCCCCGCCCCCAATGGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55688	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				TGGTCAGCTGCTAACTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55689	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				TCCATGGCAAGGCCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55690	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				GGGGCGTGGGGCACTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-101372	chr2	241948038	241950522	241008621	241011105	55691	hg19	N/A	enh6227	N/A	Enhatls108421	enhancer	E_629				TGGATGTTACAGTCCCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GPR35	direct	Highly Significant	NA					SNED1	chr2	240998617	241095568	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	13298
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55692	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				GTAAATTAGTTCAATGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55693	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				TGCTGAGAATGCAGAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55694	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				TTGGACTTTTTAATAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55695	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				GTCAGTTCTGTTTCGTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55696	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				GCTATTGTTAAAGAAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55697	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				CGAGTGAGTCATCTCTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55698	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				AGCTTTTCAGTGATACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102914	chr20	23602846	23606178	23622209	23625541	55699	hg19	N/A	enh53735	N/A	Enhatls110039	enhancer	E_632				GAGAGGAAAACCAGCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	148				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1342
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55700	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				TTTTGTTGCTTCCCATAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55701	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				GTGAAGATAAAAAAGACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55702	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				GGTCCTGGGCAGCCACACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55703	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				GGGAAGCTGACTCTACCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55704	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				AGCTCATGCTGTATGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55705	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				TACCAGGCAGGGAATGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55706	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				TTCATCAGGGTCCTGGATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55707	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				AGAAGGTGGTCCTGTTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-102915	chr20	23608977	23610173	23628340	23629536	55708	hg19	N/A	N/A	N/A	Enhatls110040	enhancer	E_633				TGAGTGGTTCTACCCCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CST3	direct	Highly Significant	NA					CST3	chr20	23626705	23638473	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1343
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55709	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55710	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55711	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55712	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55713	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55714	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55715	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55716	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55717	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55718	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55719	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55720	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55721	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55722	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55723	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55724	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55725	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55726	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55727	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CCTGAACTCAAAGCCTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55728	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55729	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55730	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55731	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55732	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55733	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55734	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55735	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55736	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55737	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55738	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55739	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55740	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55741	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55742	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55743	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55744	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55745	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55746	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				GCAACGATGTGCTGTTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55747	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55748	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55749	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55750	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55751	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55752	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55753	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55754	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55755	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55756	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55757	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55758	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55759	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55760	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55761	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55762	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55763	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55764	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55765	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AGTACCCAGTCACCAGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55766	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55767	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55768	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55769	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55770	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55771	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55772	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55773	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55774	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55775	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55776	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55777	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55778	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55779	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55780	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55781	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55782	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55783	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55784	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TCAGGCTCTGTGAGGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55785	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55786	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55787	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55788	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55789	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55790	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55791	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55792	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55793	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55794	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55795	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55796	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55797	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55798	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55799	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55800	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55801	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55802	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55803	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TCCGGGCCCTGGAGCAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55804	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55805	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55806	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55807	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55808	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55809	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55810	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55811	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55812	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55813	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55814	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55815	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55816	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55817	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55818	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55819	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55820	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55821	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55822	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CCTTCCGTCCATCACCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55823	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55824	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55825	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55826	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55827	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55828	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55829	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55830	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55831	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55832	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55833	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55834	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55835	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55836	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55837	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55838	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55839	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55840	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55841	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TCAGAGGTCCTTGCAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55842	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55843	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55844	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55845	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55846	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55847	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55848	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55849	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55850	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55851	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55852	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55853	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55854	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55855	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55856	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55857	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55858	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55859	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55860	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CGTGGGAGCTGACCTGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55861	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55862	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55863	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55864	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55865	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55866	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55867	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55868	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55869	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55870	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55871	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55872	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55873	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55874	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55875	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55876	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55877	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55878	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55879	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CCTGCATTCATGGGTGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55880	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55881	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55882	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55883	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55884	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55885	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55886	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55887	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55888	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55889	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55890	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55891	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55892	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55893	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55894	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55895	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55896	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55897	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55898	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TGTGTCCTTGGGGCTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55899	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55900	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55901	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55902	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55903	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55904	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55905	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55906	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55907	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55908	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55909	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55910	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55911	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55912	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55913	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55914	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55915	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55916	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55917	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TGTGTCCCAGAGCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55918	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55919	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55920	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55921	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55922	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55923	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55924	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55925	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55926	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55927	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55928	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55929	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55930	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55931	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55932	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55933	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55934	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55935	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55936	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TCTCTTAGAGCCCATAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55937	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55938	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55939	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55940	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55941	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55942	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55943	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55944	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55945	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55946	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55947	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55948	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55949	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55950	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55951	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55952	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55953	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55954	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55955	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AAAACAAAGATCATTTCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55956	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55957	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55958	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55959	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55960	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55961	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55962	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55963	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55964	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55965	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55966	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55967	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55968	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55969	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55970	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55971	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55972	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55973	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55974	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TAGCCTAGGGGGATCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55975	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55976	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55977	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55978	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55979	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55980	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55981	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55982	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55983	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55984	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55985	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55986	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55987	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55988	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55989	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55990	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55991	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55992	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55993	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CTAGGAACAAGTAACAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55994	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55995	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55996	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	55997	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55998	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	55999	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56000	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56001	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56002	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56003	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56004	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56005	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56006	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56007	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56008	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56009	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56010	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56011	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56012	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CCCAGTTGGGTAGTGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56013	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56014	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56015	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56016	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56017	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56018	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56019	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56020	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56021	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56022	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56023	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56024	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56025	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56026	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56027	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56028	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56029	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56030	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56031	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CCTGTAGTCTCCTGTTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56032	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56033	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56034	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56035	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56036	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56037	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56038	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56039	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56040	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56041	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56042	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56043	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56044	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56045	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56046	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56047	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56048	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56049	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56050	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				CAGTCCCAGCCCAGAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56051	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56052	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56053	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56054	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56055	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56056	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56057	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56058	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56059	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56060	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56061	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56062	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56063	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56064	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56065	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56066	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56067	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56068	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56069	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AGAGTGGGTCACGTGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56070	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56071	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56072	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56073	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56074	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56075	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56076	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56077	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56078	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56079	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56080	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56081	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56082	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56083	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56084	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56085	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56086	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56087	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56088	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AGAACAGTGCGTCAACGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56089	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56090	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56091	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56092	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56093	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56094	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56095	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56096	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56097	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56098	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56099	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56100	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56101	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56102	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56103	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56104	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56105	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56106	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56107	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AACCCAGGCACTCTGTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56108	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56109	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56110	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56111	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56112	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56113	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56114	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56115	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56116	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56117	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56118	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56119	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56120	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56121	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56122	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56123	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56124	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56125	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56126	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				ATTCTGTACTACATTCCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56127	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56128	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56129	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56130	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56131	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56132	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56133	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56134	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56135	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56136	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56137	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56138	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56139	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56140	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56141	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56142	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56143	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56144	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56145	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				AAAACGTTTAGCACAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56146	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56147	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56148	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56149	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56150	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56151	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56152	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56153	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56154	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56155	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56156	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56157	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56158	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56159	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56160	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56161	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56162	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56163	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56164	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				ACGCACGCACTCTCACGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56165	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56166	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56167	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56168	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56169	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56170	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56171	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56172	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56173	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56174	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56175	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56176	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56177	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56178	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56179	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56180	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56181	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56182	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56183	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				GCCTTTTTCCAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56184	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56185	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56186	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56187	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56188	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56189	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56190	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56191	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56192	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56193	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56194	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56195	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56196	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56197	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56198	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56199	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56200	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56201	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56202	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TCTGGAGGCCGGCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56203	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56204	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56205	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56206	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56207	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56208	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56209	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56210	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56211	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56212	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56213	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56214	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56215	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56216	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56217	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56218	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56219	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56220	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56221	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				GAGCATCCCCAGGTGTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56222	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56223	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56224	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56225	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56226	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56227	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56228	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56229	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56230	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56231	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56232	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56233	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56234	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56235	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56236	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56237	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56238	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56239	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56240	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TGGGAACCGGCGGGCGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56241	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56242	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56243	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56244	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56245	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56246	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56247	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56248	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56249	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56250	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56251	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56252	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56253	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56254	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56255	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56256	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56257	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56258	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56259	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				GTTACATGCACACACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56260	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56261	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56262	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56263	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56264	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56265	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56266	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56267	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56268	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56269	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56270	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56271	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56272	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56273	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56274	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56275	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56276	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56277	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56278	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				GGAAGATGCCGAGAAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56279	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56280	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56281	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56282	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56283	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56284	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56285	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56286	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56287	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56288	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56289	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56290	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56291	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56292	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56293	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56294	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56295	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56296	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56297	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				TTAACAGTACAGCCCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56298	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					HM13	chr20	31514427	31577923	7681				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56299	hg19	N/A	enh19571	fant58349	Enhatls110289	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	8866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56300	hg19	N/A	enh19571	N/A	Enhatls110289	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5551				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103156	chr20	30176104	30200723	31588301	31612920	56301	hg19	N/A	N/A	N/A	Enhatls110289	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	5006				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1584
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56302	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2343				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56303	hg19	N/A	enh19572	fant58350	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2092				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56304	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56305	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1236				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56306	hg19	hs480	enh19572	fant58351	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	740				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56307	hg19	hs480	enh19572	N/A	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	532				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56308	hg19	N/A	enh19572	N/A	N/A	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56309	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	524				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56310	hg19	N/A	enh19572	fant58352	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	650				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56311	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1027				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56312	hg19	N/A	enh19572	fant58353	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	1684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56313	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	2423				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56314	hg19	N/A	enh19572	fant58354	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4175				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56315	hg19	N/A	enh19572	N/A	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	4528				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103157	chr20	30176104	30200723	31588301	31612920	56316	hg19	N/A	enh19572	fant58355	Enhatls110290	enhancer	E_634				ATATTGTAAAGAGTTTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					ID1	chr20	31605282	31606515	6395				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1585
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56317	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56318	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56319	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56320	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56321	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56322	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56323	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56324	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56325	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56326	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTTTGCTGCCAAACATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56327	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56328	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56329	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56330	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56331	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56332	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56333	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56334	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56335	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56336	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				TACCCTCCTTGACAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56337	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56338	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56339	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56340	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56341	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56342	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56343	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56344	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56345	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56346	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CTGAGGGGAACTGGTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56347	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56348	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56349	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56350	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56351	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56352	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56353	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56354	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56355	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56356	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				AGGAAGGGTTCGTCTGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56357	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56358	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56359	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56360	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56361	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56362	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56363	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56364	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56365	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56366	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CTTTCCTGAAATAACCAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56367	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56368	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56369	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56370	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56371	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56372	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56373	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56374	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56375	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56376	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				AGCAGCCAGGAAAAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56377	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56378	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56379	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56380	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56381	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56382	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56383	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56384	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56385	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56386	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GCTAGAAGATCGCTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56387	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56388	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56389	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56390	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56391	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56392	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56393	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56394	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56395	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56396	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GCGGAGACTCGGAAGAAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56397	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56398	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56399	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56400	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56401	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56402	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56403	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56404	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56405	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56406	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				CCAGGCCTATGTTTCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56407	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56408	hg19	hs2050	enh6337	fant58360	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56409	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56410	hg19	hs2050	enh6337	fant58361	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56411	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56412	hg19	hs2050	enh6337	fant58362	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56413	hg19	hs2050	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56414	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56415	hg19	N/A	enh6337	fant58363	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103162	chr20	30261842	30269179	31674039	31681376	56416	hg19	N/A	enh6337	N/A	Enhatls110296	enhancer	E_635				GGTCAACACCTCAGTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					BCL2L1	chr20	31664451	31723989	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1590
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56417	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				CGAACAATCCATTTTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56418	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				CGAACAATCCATTTTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56419	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				GGAAACAGACCAGATATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56420	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				GGAAACAGACCAGATATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56421	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				GACTCAATACGAACACCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56422	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				GACTCAATACGAACACCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	direct	Highly Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56423	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				CTTTTAGAAAGGTTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56424	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				CTTTTAGAAAGGTTGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56425	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				GGGGAGAGTGGCGCACAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56426	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				GGGGAGAGTGGCGCACAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56427	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				TCGGTGCTGGTGTTTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56428	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				TCGGTGCTGGTGTTTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56429	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				CAGGTTGCTAAGGAAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56430	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				CAGGTTGCTAAGGAAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56431	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				AGGCCCGAGCCGAAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56432	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				AGGCCCGAGCCGAAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56433	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				AGGCAGGGCAGAGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56434	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				AGGCAGGGCAGAGGATGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56435	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				TCGGGCCGCGACCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56436	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				TCGGGCCGCGACCCTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56437	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				TTGGGTCGCAGCCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56438	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				TTGGGTCGCAGCCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56439	hg19	N/A	enh6343	N/A	N/A	enhancer	E_636				TCCGAACCTCGGCGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103265	chr20	30864718	30866659	32276915	32278856	56440	hg19	N/A	enh6343	N/A	Enhatls110399	enhancer	E_636				TCCGAACCTCGGCGCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	HCK	indirect	Non Significant	NA					KIF3B	chr20	32277650	32335011	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1693
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56441	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				GTGAGTGGTTCCGGTGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56442	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				GGACAGTGGACAGGCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56443	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				AAATGGGCCCTTTATTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56444	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				GCCTGGCCAGGATCTCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56445	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				ATTTAGCTGCTCTTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56446	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				AGGATTACACAGACAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56447	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				TTTTCTCCTTGAAATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103869	chr20	35107156	35119151	36478753	36490748	56448	hg19	N/A	enh34625	N/A	Enhatls111087	enhancer	E_637				ATGACATCTCCCACTGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					DLGAP4	chr20	36306335	36528637	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2297
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56449	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GACTCTTGCCCTTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56450	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				GACTCTTGCCCTTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56451	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GACTCTTGCCCTTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56452	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				TCTGTGTCAGGCCCTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56453	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				TCTGTGTCAGGCCCTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56454	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				TCTGTGTCAGGCCCTGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56455	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CATGAGCAGCTGTCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56456	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				CATGAGCAGCTGTCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56457	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CATGAGCAGCTGTCTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56458	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				AGGGGGCTAGTCCCAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56459	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				AGGGGGCTAGTCCCAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56460	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				AGGGGGCTAGTCCCAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56461	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CGGGAGAGGCTGGCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56462	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				CGGGAGAGGCTGGCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56463	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CGGGAGAGGCTGGCGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56464	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GCTTGGGGAGGGGACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56465	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				GCTTGGGGAGGGGACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56466	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GCTTGGGGAGGGGACCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56467	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GGGAGCCTAAGAATGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56468	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				GGGAGCCTAAGAATGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56469	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				GGGAGCCTAAGAATGTTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56470	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CCAGTGACAGATCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56471	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				CCAGTGACAGATCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56472	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CCAGTGACAGATCCAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56473	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CCCACTTCCACACAGTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56474	hg19	N/A	enh6389	fant58527	Enhatls111156	enhancer	E_639				CCCACTTCCACACAGTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35469852	35476808	36841449	36848405	56475	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_639				CCCACTTCCACACAGTTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56476	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				AGCTCCAAGGTGTCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56477	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				AGCTCCAAGGTGTCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56478	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				AGCTCCAAGGTGTCTGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56479	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				TGGGGCTGAGCGCTCAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56480	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				TGGGGCTGAGCGCTCAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56481	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				TGGGGCTGAGCGCTCAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56482	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				TGCAAGCACAAAGGCCGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56483	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				TGCAAGCACAAAGGCCGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56484	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				TGCAAGCACAAAGGCCGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56485	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				CTCTCCTTGACCCTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56486	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				CTCTCCTTGACCCTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56487	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				CTCTCCTTGACCCTACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56488	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				CAGCTGATCCAGCCTAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56489	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				CAGCTGATCCAGCCTAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56490	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				CAGCTGATCCAGCCTAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	indirect	Non Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56491	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GGCCCCTCATTCTCAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56492	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GGCCCCTCATTCTCAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56493	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GGCCCCTCATTCTCAAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56494	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GGAAGAGTGACACGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56495	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GGAAGAGTGACACGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56496	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GGAAGAGTGACACGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56497	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				TGCAGACACATAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56498	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				TGCAGACACATAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56499	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				TGCAGACACATAAAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56500	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GCGTTGGGCTGGCTTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56501	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GCGTTGGGCTGGCTTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56502	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GCGTTGGGCTGGCTTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56503	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GCTTGAAACGGAAAAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56504	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GCTTGAAACGGAAAAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56505	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GCTTGAAACGGAAAAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56506	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				ACAATTAAGTGAAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56507	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				ACAATTAAGTGAAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56508	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				ACAATTAAGTGAAAGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56509	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				AGGCTAACTCCCCAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56510	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				AGGCTAACTCCCCAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56511	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				AGGCTAACTCCCCAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56512	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				AGAGGTGGCTAGAGGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56513	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				AGAGGTGGCTAGAGGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56514	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				AGAGGTGGCTAGAGGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56515	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GCCCCCAGCAAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56516	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GCCCCCAGCAAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56517	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GCCCCCAGCAAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56518	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				TCTGTGGGCAGCTCGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56519	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				TCTGTGGGCAGCTCGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56520	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				TCTGTGGGCAGCTCGACAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56521	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GTCCTGGGTGGTGGGTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56522	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GTCCTGGGTGGTGGGTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56523	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GTCCTGGGTGGTGGGTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56524	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GTTTGTACACATTAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56525	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GTTTGTACACATTAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56526	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GTTTGTACACATTAGCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56527	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				GTGCGTGTGTCTAGGTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56528	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				GTGCGTGTGTCTAGGTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56529	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				GTGCGTGTGTCTAGGTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56530	hg19	N/A	enh6389	N/A	Enhatls111156	enhancer	E_640				CAGTCTGGCATGCAAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103930	chr20	35480151	35494632	36851748	36866229	56531	hg19	N/A	enh6389	N/A	N/A	enhancer	E_640				CAGTCTGGCATGCAAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2358
enhrx-103931	chr20	35480151	35494632	36851748	36866229	56532	hg19	N/A	N/A	fant58528	N/A	enhancer	E_640				CAGTCTGGCATGCAAACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					MTCL2	chr20	36777446	36863538	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2359
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56533	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56534	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56535	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56536	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56537	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56538	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GGTGACTTGGTGGGTGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56539	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56540	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56541	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56542	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56543	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56544	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CCTCAAAGGACCTTTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56545	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56546	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56547	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56548	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56549	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56550	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				TTAGAAGTATAGGCTGTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56551	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56552	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56553	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56554	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56555	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56556	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AAGGCACTGTTTTCAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56557	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56558	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56559	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56560	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56561	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56562	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GCCGACAGCACATTCTCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56563	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56564	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56565	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56566	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56567	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56568	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GGAGTTTTTGTGTCTGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56569	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56570	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56571	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56572	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56573	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56574	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GTACAATGAGGGTAAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56575	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56576	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56577	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56578	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56579	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56580	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AGTTTTAATCTGTCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56581	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56582	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56583	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56584	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56585	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56586	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CGTCTTTTTACTGTTCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56587	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56588	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56589	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56590	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56591	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56592	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CACAAAAAATACTAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56593	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56594	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56595	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56596	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56597	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56598	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GAAGCAGCTGAGGTCCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56599	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56600	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56601	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56602	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56603	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56604	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				ATCTATGGAGTACATTATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56605	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56606	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56607	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56608	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56609	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56610	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				GTAAAAAGGGCCTAGTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56611	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56612	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56613	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56614	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56615	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56616	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				CTATGTTAAATAATGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56617	hg19	N/A	N/A	N/A	Enhatls111298	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56618	hg19	N/A	enh6408	N/A	Enhatls111298	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56619	hg19	N/A	enh6408	N/A	N/A	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56620	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56621	hg19	N/A	enh6408	fant58589	Enhatls111299	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36717009	36724500	38088607	38096098	56622	hg19	N/A	enh6408	N/A	Enhatls111299	enhancer	E_641				AAGGAGTAATAGAGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56623	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				TCTGGACCATTGGATCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56624	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				GGACTGCTGATAAGTGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56625	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				CTGAGCACTTCATCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56626	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				ACTTTCCCATGACTCAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56627	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				CTTAAGAACCCAAAGTAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56628	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				CTAGTTTACCCGGAATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56629	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				GAGATAAGAAATCTACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56630	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				GGCCGGGTAGATGATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56631	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				AGTGAACTCCTGGTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56632	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				ATGGGGCACCGCAGGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56633	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				ACCCATCCTCCCAAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56634	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				ACAAAATGATTAAATGATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56635	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				TAAGTTCTAGGCTGTTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56636	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				CATGGAGGACCTGTTTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56637	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				TGGCATTCAAAGAAGGTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56638	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				CTGGGTTCTGAGTAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56639	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				GAATGAACGGTGAATTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36738448	36751668	38110046	38123266	56640	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_642				TTTTGGACATCCAAAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56641	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56642	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56643	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56644	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56645	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56646	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56647	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56648	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56649	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56650	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56651	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56652	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56653	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56654	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56655	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56656	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56657	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56658	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56659	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56660	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56661	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56662	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56663	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GAAGCCACACTGTGAGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56664	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56665	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56666	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56667	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56668	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56669	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56670	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56671	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56672	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56673	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56674	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56675	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56676	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56677	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56678	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56679	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56680	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56681	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56682	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56683	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56684	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56685	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56686	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CCAAGCTATGAGCAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56687	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56688	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56689	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56690	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56691	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56692	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56693	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56694	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56695	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56696	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56697	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56698	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56699	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56700	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56701	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56702	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56703	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56704	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56705	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56706	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56707	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56708	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56709	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AGCCCTCACATGGGGTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56710	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56711	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56712	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56713	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56714	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56715	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56716	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56717	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56718	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56719	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56720	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56721	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56722	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56723	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56724	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56725	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56726	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56727	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56728	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56729	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56730	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56731	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56732	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GGAAGGATACTGACTCTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56733	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56734	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56735	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56736	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56737	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56738	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56739	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56740	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56741	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56742	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56743	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56744	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56745	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56746	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56747	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56748	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56749	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56750	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56751	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56752	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56753	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56754	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56755	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CCCCGGAGTGGGGCAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56756	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56757	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56758	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56759	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56760	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56761	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56762	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56763	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56764	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56765	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56766	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56767	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56768	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56769	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56770	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56771	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56772	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56773	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56774	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56775	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56776	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56777	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56778	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TCAGGGCACAGCCCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56779	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56780	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56781	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56782	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56783	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56784	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56785	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56786	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56787	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56788	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56789	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56790	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56791	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56792	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56793	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56794	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56795	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56796	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56797	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56798	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56799	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56800	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56801	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AGTATCGTAAAGGTCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56802	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56803	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56804	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56805	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56806	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56807	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56808	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56809	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56810	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56811	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56812	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56813	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56814	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56815	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56816	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56817	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56818	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56819	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56820	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56821	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56822	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56823	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56824	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TCCTTGGGGCAGGGTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56825	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56826	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56827	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56828	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56829	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56830	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56831	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56832	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56833	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56834	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56835	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56836	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56837	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56838	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56839	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56840	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56841	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56842	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56843	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56844	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56845	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56846	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56847	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AATACAGAGAGGGTAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56848	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56849	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56850	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56851	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56852	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56853	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56854	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56855	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56856	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56857	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56858	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56859	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56860	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56861	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56862	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56863	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56864	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56865	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56866	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56867	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56868	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56869	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56870	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GAGCCTGCGGAAGCCACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56871	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56872	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56873	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56874	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56875	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56876	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56877	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56878	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56879	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56880	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56881	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56882	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56883	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56884	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56885	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56886	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56887	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56888	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56889	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56890	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56891	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56892	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56893	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TATGTTGGTTCTAGGGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56894	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56895	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56896	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56897	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56898	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56899	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56900	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56901	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56902	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56903	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56904	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56905	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56906	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56907	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56908	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56909	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56910	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56911	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56912	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56913	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56914	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56915	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56916	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TCATTCCAGAAGTATCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56917	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56918	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56919	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56920	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56921	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56922	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56923	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56924	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56925	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56926	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56927	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56928	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56929	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56930	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56931	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56932	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56933	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56934	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56935	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56936	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56937	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56938	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56939	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TGTAGCGTCCAAGGAACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56940	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56941	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56942	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56943	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56944	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56945	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56946	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56947	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56948	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56949	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56950	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56951	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56952	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56953	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56954	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56955	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56956	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56957	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56958	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56959	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56960	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56961	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56962	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CTTTCTACATGACTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56963	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56964	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56965	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56966	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56967	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56968	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56969	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56970	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56971	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56972	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56973	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56974	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56975	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56976	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56977	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56978	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56979	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56980	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56981	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56982	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56983	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	56984	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	56985	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AGGTCTAGACTGCGATTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56986	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56987	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	56988	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	56989	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56990	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56991	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	56992	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56993	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56994	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	56995	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56996	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56997	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56998	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	56999	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57000	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57001	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57002	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57003	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57004	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57005	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57006	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57007	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57008	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CAACTGTCGACTATTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57009	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57010	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57011	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57012	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57013	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57014	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57015	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57016	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57017	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57018	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57019	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57020	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57021	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57022	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57023	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57024	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57025	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57026	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57027	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57028	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57029	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57030	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57031	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CTTGGTCTTGGGCCAGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57032	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57033	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57034	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57035	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57036	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57037	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57038	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57039	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57040	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57041	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57042	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57043	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57044	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57045	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57046	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57047	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57048	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57049	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57050	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57051	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57052	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57053	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57054	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CAGAGTAACCTTCTAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57055	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57056	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57057	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57058	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57059	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57060	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57061	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57062	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57063	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57064	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57065	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57066	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57067	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57068	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57069	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57070	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57071	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57072	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57073	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57074	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57075	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57076	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57077	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				ATTCCTGTGACCCACCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57078	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57079	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57080	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57081	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57082	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57083	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57084	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57085	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57086	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57087	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57088	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57089	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57090	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57091	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57092	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57093	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57094	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57095	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57096	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57097	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57098	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57099	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57100	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GGATTCCTTTCAGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57101	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57102	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57103	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57104	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57105	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57106	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57107	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57108	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57109	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57110	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57111	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57112	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57113	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57114	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57115	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57116	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57117	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57118	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57119	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57120	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57121	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57122	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57123	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TTGGCATTGGAGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57124	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57125	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57126	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57127	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57128	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57129	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57130	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57131	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57132	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57133	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57134	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57135	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57136	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57137	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57138	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57139	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57140	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57141	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57142	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57143	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57144	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57145	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57146	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CCAGTGGATCCCCAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57147	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57148	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57149	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57150	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57151	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57152	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57153	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57154	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57155	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57156	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57157	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57158	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57159	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57160	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57161	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57162	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57163	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57164	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57165	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57166	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57167	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57168	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57169	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CGATGGTGACTTAGAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57170	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57171	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57172	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57173	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57174	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57175	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57176	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57177	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57178	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57179	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57180	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57181	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57182	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57183	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57184	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57185	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57186	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57187	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57188	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57189	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57190	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57191	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57192	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GGAAGTGATTTTGGTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57193	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57194	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57195	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57196	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57197	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57198	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57199	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57200	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57201	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57202	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57203	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57204	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57205	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57206	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57207	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57208	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57209	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57210	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57211	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57212	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57213	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57214	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57215	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AATCTCCTGGCAGGAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57216	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57217	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57218	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57219	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57220	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57221	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57222	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57223	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57224	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57225	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57226	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57227	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57228	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57229	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57230	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57231	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57232	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57233	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57234	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57235	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57236	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57237	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57238	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TGTAGGAGCTTCGAGGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57239	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57240	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57241	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57242	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57243	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57244	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57245	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57246	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57247	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57248	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57249	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57250	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57251	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57252	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57253	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57254	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57255	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57256	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57257	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57258	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57259	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57260	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57261	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GGTCTTATCCCACCATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57262	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57263	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57264	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57265	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57266	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57267	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57268	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57269	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57270	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57271	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57272	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57273	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57274	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57275	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57276	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57277	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57278	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57279	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57280	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57281	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57282	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57283	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57284	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				CTCCTCATCAGTCTAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57285	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57286	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57287	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57288	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57289	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57290	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57291	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57292	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57293	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57294	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57295	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57296	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57297	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57298	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57299	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57300	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57301	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57302	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57303	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57304	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57305	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57306	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57307	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				TCATACAGCTGGTGAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57308	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57309	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57310	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57311	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57312	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57313	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57314	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57315	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57316	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57317	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57318	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57319	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57320	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57321	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57322	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57323	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57324	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57325	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57326	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57327	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57328	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57329	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57330	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				ATTAGCTTGTCTTACTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57331	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57332	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57333	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57334	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57335	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57336	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57337	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57338	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57339	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57340	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57341	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57342	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57343	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57344	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57345	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57346	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57347	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57348	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57349	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57350	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57351	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57352	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57353	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				GGTGATTCAGAGAGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57354	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57355	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57356	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57357	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57358	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57359	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57360	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57361	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57362	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57363	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57364	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57365	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57366	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57367	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57368	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57369	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57370	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57371	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57372	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57373	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57374	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57375	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57376	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AGGGATCCGGCTAAGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57377	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57378	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57379	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57380	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57381	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57382	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57383	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57384	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57385	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57386	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57387	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57388	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57389	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57390	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57391	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57392	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57393	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57394	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57395	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57396	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57397	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57398	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57399	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				ATAGGAAGCTCTTAATACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57400	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57401	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57402	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57403	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57404	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57405	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57406	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57407	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57408	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57409	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57410	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57411	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57412	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57413	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57414	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57415	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57416	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57417	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57418	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57419	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57420	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57421	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57422	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				ACTAACCCCTGGGTGGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57423	hg19	N/A	enh19620	N/A	Enhatls111299	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57424	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104066	chr20	36753106	36776824	38124704	38148422	57425	hg19	N/A	N/A	N/A	Enhatls111299	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					RPRD1B	chr20	38033745	38127780	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2494
enhrx-104067	chr20	36753106	36776824	38124704	38148422	57426	hg19	N/A	N/A	N/A	Enhatls111300	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2495
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57427	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57428	hg19	N/A	N/A	fant58590	Enhatls111301	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104068	chr20	36753106	36776824	38124704	38148422	57429	hg19	N/A	N/A	N/A	Enhatls111301	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2496
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57430	hg19	N/A	N/A	N/A	Enhatls111302	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57431	hg19	N/A	enh19621	N/A	Enhatls111302	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104069	chr20	36753106	36776824	38124704	38148422	57432	hg19	N/A	enh19621	N/A	N/A	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2497
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57433	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57434	hg19	N/A	enh19622	N/A	Enhatls111303	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57435	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57436	hg19	N/A	enh19622	N/A	Enhatls111304	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57437	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57438	hg19	N/A	enh19622	N/A	Enhatls111305	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57439	hg19	N/A	enh19622	N/A	N/A	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57440	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57441	hg19	N/A	enh19622	fant58591	Enhatls111306	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57442	hg19	N/A	enh19622	N/A	Enhatls111306	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104070	chr20	36753106	36776824	38124704	38148422	57443	hg19	N/A	N/A	N/A	Enhatls111306	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2498
enhrx-104071	chr20	36753106	36776824	38124704	38148422	57444	hg19	N/A	N/A	N/A	Enhatls111307	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2499
enhrx-104072	chr20	36753106	36776824	38124704	38148422	57445	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_643				AGTCCAGCTCCAGAGTTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57446	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57447	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57448	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57449	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57450	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57451	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57452	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57453	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57454	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57455	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57456	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57457	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57458	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ACGGGCATGACAAAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57459	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57460	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57461	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57462	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57463	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57464	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57465	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57466	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57467	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57468	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57469	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57470	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57471	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TCATCGTAGTGAGGAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57472	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57473	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57474	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57475	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57476	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57477	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57478	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57479	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57480	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57481	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57482	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57483	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57484	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ATGGCTCTGCAGCAGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57485	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57486	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57487	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57488	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57489	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57490	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57491	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57492	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57493	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57494	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57495	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57496	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57497	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GTGCCCCCACCTTTACCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57498	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57499	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57500	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57501	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57502	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57503	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57504	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57505	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57506	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57507	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57508	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57509	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57510	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CTTGGAACTGACATACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57511	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57512	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57513	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57514	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57515	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57516	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57517	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57518	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57519	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57520	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57521	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57522	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57523	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CTAAAGTGACCCACATCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57524	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57525	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57526	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57527	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57528	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57529	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57530	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57531	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57532	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57533	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57534	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57535	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57536	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GGAATGGGAAGCGTGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57537	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57538	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57539	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57540	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57541	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57542	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57543	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57544	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57545	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57546	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57547	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57548	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57549	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CCAACAGGACAGGAACACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57550	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57551	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57552	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57553	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57554	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57555	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57556	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57557	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57558	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57559	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57560	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57561	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57562	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GAATTTTAGTCAATCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57563	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57564	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57565	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57566	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57567	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57568	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57569	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57570	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57571	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57572	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57573	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57574	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57575	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GTCCCGAGAAATCATTCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57576	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57577	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57578	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57579	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57580	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57581	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57582	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57583	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57584	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57585	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57586	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57587	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57588	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CTGGAGGCTCATGGCACGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57589	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57590	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57591	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57592	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57593	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57594	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57595	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57596	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57597	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57598	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57599	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57600	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57601	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TGGGGGCTGGACCATCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57602	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57603	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57604	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57605	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57606	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57607	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57608	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57609	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57610	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57611	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57612	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57613	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57614	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TTATAGGGAGGTACTGCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57615	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57616	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57617	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57618	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57619	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57620	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57621	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57622	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57623	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57624	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57625	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57626	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57627	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ACTATACACCAGGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57628	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57629	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57630	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57631	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57632	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57633	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57634	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57635	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57636	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57637	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57638	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57639	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57640	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ACCCTCTAAACAGAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57641	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57642	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57643	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57644	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57645	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57646	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57647	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57648	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57649	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57650	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57651	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57652	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57653	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TATCGTCAGTGTTATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57654	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57655	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57656	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57657	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57658	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57659	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57660	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57661	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57662	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57663	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57664	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57665	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57666	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AGTCCTCACGATCTGCTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57667	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57668	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57669	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57670	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57671	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57672	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57673	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57674	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57675	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57676	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57677	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57678	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57679	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ATTGAAGAACTTCACAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57680	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57681	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57682	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57683	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57684	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57685	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57686	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57687	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57688	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57689	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57690	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57691	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57692	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AGCAACAGGCAGACCGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57693	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57694	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57695	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57696	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57697	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57698	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57699	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57700	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57701	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57702	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57703	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57704	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57705	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TCCTGACCCCCAATGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57706	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57707	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57708	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57709	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57710	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57711	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57712	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57713	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57714	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57715	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57716	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57717	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57718	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CCCCGCCCGACCATGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57719	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57720	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57721	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57722	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57723	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57724	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57725	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57726	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57727	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57728	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57729	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57730	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57731	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ACTGGCGGCTGGCACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57732	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57733	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57734	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57735	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57736	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57737	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57738	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57739	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57740	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57741	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57742	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57743	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57744	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AGGGGACCGGAGCCCGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57745	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57746	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57747	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57748	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57749	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57750	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57751	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57752	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57753	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57754	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57755	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57756	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57757	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GACCTTGGAGAACAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57758	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57759	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57760	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57761	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57762	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57763	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57764	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57765	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57766	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57767	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57768	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57769	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57770	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TCACAGCCAGCATCCATTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57771	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57772	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57773	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57774	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57775	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57776	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57777	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57778	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57779	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57780	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57781	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57782	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57783	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AGTTCTGTGGAATGTGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57784	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57785	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57786	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57787	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57788	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57789	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57790	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57791	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57792	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57793	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57794	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57795	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57796	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GCATGGCGTTGAGCAACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57797	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57798	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57799	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57800	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57801	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57802	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57803	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57804	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57805	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57806	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57807	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57808	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57809	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GGGTGCCTGGTCACTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57810	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57811	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57812	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57813	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57814	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57815	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57816	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57817	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57818	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57819	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57820	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57821	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57822	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CCCATTTGTTCAAAGGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57823	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57824	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57825	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57826	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57827	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57828	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57829	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57830	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57831	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57832	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57833	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57834	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57835	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TCCCCTGAATAGATGACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57836	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57837	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57838	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57839	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57840	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57841	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57842	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57843	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57844	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57845	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57846	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57847	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57848	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GTGACTCTGGATAAGTTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57849	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57850	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57851	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57852	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57853	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57854	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57855	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57856	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57857	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57858	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57859	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57860	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57861	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				ATCTCTAATCCCCAGTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57862	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57863	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57864	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57865	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57866	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57867	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57868	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57869	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57870	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57871	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57872	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57873	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57874	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TGATGATGTCATCAAGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57875	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57876	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57877	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57878	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57879	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57880	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57881	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57882	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57883	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57884	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57885	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57886	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57887	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GAGGTGCAGTGTATTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57888	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57889	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57890	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57891	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57892	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57893	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57894	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57895	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57896	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57897	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57898	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57899	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57900	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CTTGCTGGAATATCATGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57901	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57902	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57903	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57904	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57905	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57906	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57907	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57908	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57909	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57910	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57911	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57912	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57913	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AGGGGAATGCTGTAGTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57914	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57915	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57916	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57917	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57918	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57919	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57920	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57921	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57922	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57923	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57924	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57925	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57926	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				TGACTCTTATTGACTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57927	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57928	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57929	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57930	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57931	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57932	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57933	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57934	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57935	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57936	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57937	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57938	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57939	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AAATGACCCTTTGGGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57940	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57941	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57942	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57943	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57944	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57945	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57946	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57947	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57948	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57949	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57950	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57951	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57952	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				AAGCAGCTCATCAGACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57953	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57954	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57955	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57956	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57957	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57958	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57959	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57960	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57961	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57962	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57963	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57964	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57965	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				CCAGCATCACAGGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57966	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57967	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57968	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57969	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57970	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57971	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57972	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57973	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57974	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57975	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57976	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57977	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57978	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GACTCGCTGTGCCTACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57979	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57980	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57981	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57982	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57983	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57984	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57985	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57986	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	57987	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	57988	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57989	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57990	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	57991	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GACCTGTCCTTAACTAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104072	chr20	36778016	36804587	38149614	38176185	57992	hg19	N/A	N/A	N/A	Enhatls111308	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2500
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57993	hg19	N/A	N/A	N/A	Enhatls111309	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57994	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57995	hg19	N/A	enh34630	fant58592	Enhatls111309	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57996	hg19	N/A	enh34630	N/A	Enhatls111309	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57997	hg19	N/A	enh34630	N/A	N/A	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57998	hg19	N/A	enh34630	N/A	Enhatls111310	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104073	chr20	36778016	36804587	38149614	38176185	57999	hg19	N/A	N/A	N/A	Enhatls111310	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2501
enhrx-104074	chr20	36778016	36804587	38149614	38176185	58000	hg19	N/A	N/A	N/A	Enhatls111311	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2502
enhrx-104075	chr20	36778016	36804587	38149614	38176185	58001	hg19	N/A	N/A	fant58593	N/A	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	1729				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2503
enhrx-104076	chr20	36778016	36804587	38149614	38176185	58002	hg19	N/A	enh19623	N/A	N/A	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	2826				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	58003	hg19	N/A	enh19623	N/A	Enhatls111312	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	3721				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-104076	chr20	36778016	36804587	38149614	38176185	58004	hg19	N/A	N/A	N/A	Enhatls111312	enhancer	E_644				GTCCCAGAAGAGCTTCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SRC	direct	Highly Significant	NA					TGM2	chr20	38127384	38166578	9476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2504
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58005	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				AGATTTCACCCATTTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58006	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				AGATTTCACCCATTTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58007	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				AGATTTCACCCATTTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58008	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				AGATTTCACCCATTTCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58009	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GCGGGCACAAAGGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58010	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GCGGGCACAAAGGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58011	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GCGGGCACAAAGGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58012	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GCGGGCACAAAGGTGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58013	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGTGGGTGCAGGTCTTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58014	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GGTGGGTGCAGGTCTTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58015	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGTGGGTGCAGGTCTTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58016	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GGTGGGTGCAGGTCTTTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58017	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGTGGGCGGAGAGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58018	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TGGTGGGCGGAGAGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58019	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGTGGGCGGAGAGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58020	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TGGTGGGCGGAGAGGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58021	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAGCTAGCGGGTGAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58022	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GAGCTAGCGGGTGAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58023	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAGCTAGCGGGTGAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58024	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GAGCTAGCGGGTGAGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58025	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGGCGGAGCTGACCCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58026	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GGGCGGAGCTGACCCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58027	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGGCGGAGCTGACCCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58028	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GGGCGGAGCTGACCCGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58029	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GTTGCTGGGTCCGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58030	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GTTGCTGGGTCCGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58031	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GTTGCTGGGTCCGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58032	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GTTGCTGGGTCCGGCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58033	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACGGCGCGCGGGGACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58034	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				ACGGCGCGCGGGGACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58035	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACGGCGCGCGGGGACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58036	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				ACGGCGCGCGGGGACTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58037	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACGTCCGCAGGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58038	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				ACGTCCGCAGGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58039	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACGTCCGCAGGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58040	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				ACGTCCGCAGGGCCGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58041	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTCTCTGGCTGTCAACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58042	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TTCTCTGGCTGTCAACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58043	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTCTCTGGCTGTCAACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58044	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TTCTCTGGCTGTCAACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58045	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACAACTCCGCAGGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58046	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				ACAACTCCGCAGGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58047	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACAACTCCGCAGGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58048	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				ACAACTCCGCAGGCAACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58049	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAGGAGCAGCGAGCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58050	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GAGGAGCAGCGAGCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58051	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAGGAGCAGCGAGCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58052	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GAGGAGCAGCGAGCGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58053	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGAAGAGCAGGCGTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58054	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TGGAAGAGCAGGCGTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58055	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGAAGAGCAGGCGTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58056	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TGGAAGAGCAGGCGTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58057	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTAGCACCAATGGAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58058	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TTAGCACCAATGGAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58059	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTAGCACCAATGGAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58060	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TTAGCACCAATGGAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58061	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTTATTTAAAAAGACTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58062	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TTTATTTAAAAAGACTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58063	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TTTATTTAAAAAGACTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58064	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TTTATTTAAAAAGACTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58065	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAATGGCAAGCCCAGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58066	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GAATGGCAAGCCCAGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58067	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GAATGGCAAGCCCAGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58068	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GAATGGCAAGCCCAGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58069	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TCACCGGGCGATGAATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58070	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TCACCGGGCGATGAATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58071	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TCACCGGGCGATGAATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58072	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TCACCGGGCGATGAATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58073	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGGAGACAACTCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58074	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				TGGGAGACAACTCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58075	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				TGGGAGACAACTCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58076	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				TGGGAGACAACTCCATGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58077	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				AGGAGGCATGATGAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58078	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				AGGAGGCATGATGAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58079	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				AGGAGGCATGATGAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58080	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				AGGAGGCATGATGAAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58081	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GCCTTCTCCAGTCCGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58082	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GCCTTCTCCAGTCCGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58083	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GCCTTCTCCAGTCCGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58084	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GCCTTCTCCAGTCCGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58085	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGAGGCATCCGAGACCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58086	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				GGAGGCATCCGAGACCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58087	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				GGAGGCATCCGAGACCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58088	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				GGAGGCATCCGAGACCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58089	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACAAGGTCAATGTGGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58090	hg19	N/A	N/A	fant59277	Enhatls112572	enhancer	E_645				ACAAGGTCAATGTGGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58091	hg19	N/A	N/A	N/A	Enhatls112572	enhancer	E_645				ACAAGGTCAATGTGGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105255	chr20	54933875	54937499	56358819	56362443	58092	hg19	N/A	enh91376	N/A	Enhatls112572	enhancer	E_645				ACAAGGTCAATGTGGCTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					FAM210B	chr20	56358973	56368663	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3683
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58093	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				GCATTTGTGGCATTGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58094	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				CCTCCAGTGAGTAGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58095	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				CTTCAGGGGACATTTTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58096	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				CTGGGCTTCAGGTCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58097	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				TGAGCCGATGTAGAACGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58098	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				CGCTGGTTTCTGCTTGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58099	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				TTGGTATACCCAGGAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58100	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				GGCAACCTCAACGTACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58101	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				GTTCCCTCTGAGGTTTAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58102	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				AGCAGGTCGCTGGAAAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55574857	55584501	56999801	57009445	58103	hg19	N/A	enh19791	N/A	Enhatls112614	enhancer	E_647				CCAGATAAAACAAAATGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	158354				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58104	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58105	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58106	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58107	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58108	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58109	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				AGAAACGGAGCCACAGGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58110	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58111	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58112	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58113	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58114	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58115	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				TGCAAAATAATGTTAATACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58116	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58117	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58118	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58119	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58120	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58121	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				TCAAGGAAGGCAGTTAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58122	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58123	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58124	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58125	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58126	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58127	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GCCAGCACAGACATGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58128	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58129	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58130	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58131	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58132	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58133	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GGTAGGGATCATGAAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58134	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58135	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58136	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58137	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58138	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58139	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GAGCCATCCAACATGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58140	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58141	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58142	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58143	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58144	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58145	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GCAGGAGAGAGGGGGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58146	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58147	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58148	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58149	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58150	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58151	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				TAAAAATGGCCCCAAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58152	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58153	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58154	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58155	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58156	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58157	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GATTCCTTGAACACAAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58158	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58159	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58160	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58161	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58162	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58163	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CCACGGAGTGACTAACGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58164	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58165	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58166	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58167	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58168	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58169	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CCCCGGCAGGATGAAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58170	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58171	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58172	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58173	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58174	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58175	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				TCTGAGATGTCAATTACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58176	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58177	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58178	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58179	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58180	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58181	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CATGTGTTACTATTACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58182	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58183	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58184	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58185	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58186	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58187	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				AAGGAGGGTTTGCACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58188	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58189	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58190	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58191	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58192	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58193	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CCCTCAGTAGAACTGTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58194	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58195	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58196	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58197	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58198	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58199	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CAAAGCAGTACAGCTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58200	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58201	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58202	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58203	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58204	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58205	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				ATCAGCCTGTGCGTGTGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58206	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58207	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58208	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58209	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58210	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58211	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				AACCAGAAATTTACATTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58212	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58213	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58214	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58215	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58216	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58217	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				TTACAGGTTAAGGCCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58218	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58219	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58220	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58221	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58222	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58223	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CTGTGGGGGCCGCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58224	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58225	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58226	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58227	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58228	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58229	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				AGGTAAACCCCACATCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58230	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58231	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58232	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58233	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58234	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58235	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				CAGGTTGGGGAATGGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58236	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58237	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58238	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58239	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58240	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58241	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				ATTAGTTTCAAGAAGAAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58242	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58243	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58244	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58245	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58246	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58247	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				AGAGCTCTCTCTATAGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58248	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58249	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58250	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58251	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58252	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58253	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GTGTGTGTGTGTTTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58254	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58255	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58256	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58257	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58258	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58259	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GCTGTCTATTAGATCTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58260	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	145404				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58261	hg19	N/A	enh97151	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	141254				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58262	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	140084				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58263	hg19	N/A	enh34711	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	134594				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58264	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	132124				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55593774	55616934	57018718	57041878	58265	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_648				GCCCTCAAACTAAGCCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	indirect	Non Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58266	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				CCGACTCAGCCAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58267	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				CCGACTCAGCCAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58268	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GAGACCCAGAACCACTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58269	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GAGACCCAGAACCACTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58270	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GCAAGTGAAACACCCGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58271	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GCAAGTGAAACACCCGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58272	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GCAACTGGTTTTGCTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58273	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GCAACTGGTTTTGCTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58274	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				ACAGTACCTGGCCCCTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58275	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				ACAGTACCTGGCCCCTAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58276	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GCCGGGATGTAATATCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58277	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GCCGGGATGTAATATCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58278	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				AAAGCCTGATAAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58279	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				AAAGCCTGATAAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58280	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				TTTGAGTCACGACATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58281	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				TTTGAGTCACGACATTAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58282	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				AGCCCTCAGCAGCTTTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58283	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				AGCCCTCAGCAGCTTTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58284	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GGCCACAGCGAAGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58285	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GGCCACAGCGAAGTGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58286	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GAGTACTACTTGCCATCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58287	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GAGTACTACTTGCCATCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58288	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				CTGGGCCGTTCTCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58289	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				CTGGGCCGTTCTCTGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58290	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				ACCTTGCTGTCACCCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58291	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				ACCTTGCTGTCACCCTGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58292	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GTTGAGAATGGGCAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58293	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GTTGAGAATGGGCAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58294	hg19	N/A	enh19792	N/A	Enhatls112614	enhancer	E_649				GTGAAGATGAAATCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	118294				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105299	chr20	55618004	55626744	57042948	57051688	58295	hg19	N/A	N/A	N/A	Enhatls112614	enhancer	E_649				GTGAAGATGAAATCACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					BMP7	chr20	57168752	57266641	116904				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3727
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58296	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				TTGTGCTTAGTGCCTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58297	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				TTGTGCTTAGTGCCTGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58298	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				CTGAGGGCGGATCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58299	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				CTGAGGGCGGATCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58300	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GTTAGAACTACGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58301	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GTTAGAACTACGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58302	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GCGGCAGGCTACAAAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58303	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GCGGCAGGCTACAAAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58304	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GCGCACGTCGGCGCGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58305	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GCGCACGTCGGCGCGCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58306	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GGAGCGCGCGGGGCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58307	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GGAGCGCGCGGGGCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58308	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GCGAGCCGTGCATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58309	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GCGAGCCGTGCATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58310	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				CTCGAAGTACTTCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58311	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				CTCGAAGTACTTCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58312	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				GGCCGCGATAAGGTGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58313	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				GGCCGCGATAAGGTGTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58314	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				CTCCGGGGCACACGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58315	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				CTCCGGGGCACACGCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58316	hg19	N/A	enh6555	N/A	N/A	enhancer	E_650				CCCGGGAGAGGCGGCAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105329	chr20	55965286	55967076	57390230	57392020	58317	hg19	N/A	enh6555	N/A	Enhatls112643	enhancer	E_650				CCCGGGAGAGGCGGCAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					RBM38	chr20	57391395	57409333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3757
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58318	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				ATTTTGATTCCTCATTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58319	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				ATTTTGATTCCTCATTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58320	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				ATTTTGATTCCTCATTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58321	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				ATTTTGATTCCTCATTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58322	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GATTTGCAGCTCCATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58323	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GATTTGCAGCTCCATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58324	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GATTTGCAGCTCCATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58325	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GATTTGCAGCTCCATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58326	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTTTGCAAACATGAGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58327	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GTTTGCAAACATGAGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58328	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTTTGCAAACATGAGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58329	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GTTTGCAAACATGAGTCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58330	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GAGCTGCTCAGCCATACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58331	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GAGCTGCTCAGCCATACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58332	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GAGCTGCTCAGCCATACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58333	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GAGCTGCTCAGCCATACTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58334	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTACAAGCCAGCCCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58335	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GTACAAGCCAGCCCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58336	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTACAAGCCAGCCCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58337	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GTACAAGCCAGCCCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58338	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CGGCAATACCCAAACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58339	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				CGGCAATACCCAAACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58340	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CGGCAATACCCAAACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58341	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				CGGCAATACCCAAACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58342	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTGGAAATGGTGCTCTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58343	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GTGGAAATGGTGCTCTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58344	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTGGAAATGGTGCTCTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58345	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GTGGAAATGGTGCTCTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58346	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTCAGGAGGGGAACGTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58347	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GTCAGGAGGGGAACGTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58348	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GTCAGGAGGGGAACGTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58349	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GTCAGGAGGGGAACGTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58350	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TCCCACTCTCAGTAGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58351	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				TCCCACTCTCAGTAGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58352	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TCCCACTCTCAGTAGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58353	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				TCCCACTCTCAGTAGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58354	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GGGCCTTGTCCAGCATACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58355	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				GGGCCTTGTCCAGCATACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58356	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				GGGCCTTGTCCAGCATACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58357	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				GGGCCTTGTCCAGCATACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58358	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				ACACTCCCCAGCTTTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58359	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				ACACTCCCCAGCTTTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58360	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				ACACTCCCCAGCTTTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58361	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				ACACTCCCCAGCTTTGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58362	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TTTCTAAATTTACCAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58363	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				TTTCTAAATTTACCAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58364	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TTTCTAAATTTACCAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58365	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				TTTCTAAATTTACCAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58366	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TTATCTCTGGAACCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58367	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				TTATCTCTGGAACCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58368	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				TTATCTCTGGAACCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58369	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				TTATCTCTGGAACCAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58370	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CTATTGCTCTGGCCAATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58371	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				CTATTGCTCTGGCCAATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58372	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CTATTGCTCTGGCCAATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58373	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				CTATTGCTCTGGCCAATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58374	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CCACTAGCTTAGCTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	5197				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58375	hg19	N/A	enh82281	N/A	Enhatls112673	enhancer	E_651				CCACTAGCTTAGCTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	427				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105353	chr20	56170860	56179946	57595804	57604890	58376	hg19	N/A	N/A	N/A	Enhatls112673	enhancer	E_651				CCACTAGCTTAGCTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3781
enhrx-105354	chr20	56170860	56179946	57595804	57604890	58377	hg19	N/A	N/A	N/A	Enhatls112674	enhancer	E_651				CCACTAGCTTAGCTACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2C	direct	Highly Significant	NA					ZBP1	chr20	57603845	57620576	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3782
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58378	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				GCCTTCCTGAAGTGCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58379	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				ATTGGAGGTCGAGCTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58380	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				TCACTCAGAACTAACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58381	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				CAGCCCCTGCCATCCAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58382	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				GTCTTACTGCCAAAACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58383	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				TTTGATGCTGCGGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58384	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				TTAGGCCTGGGAACAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107428	chr21	43033041	43037393	41612881	41617233	58385	hg19	N/A	enh34958	N/A	N/A	enhancer	E_652				CGGGAGGCCAGGATGGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TMPRSS2	chr21	41464299	41531116	77350				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1311
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58386	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58387	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58388	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58389	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58390	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58391	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GAGGGGCCGTAGGGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58392	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58393	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58394	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58395	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58396	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58397	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAACCGTTGAGGTGGTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58398	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58399	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58400	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58401	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58402	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58403	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CGATTTCTGTCACTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58404	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58405	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58406	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58407	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58408	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58409	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCTACGTGTTTAAGTCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58410	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58411	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58412	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58413	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58414	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58415	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GCCAGGATGTCAGCAGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58416	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58417	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58418	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58419	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58420	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58421	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GTGTTTAGCTCTCCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58422	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58423	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58424	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58425	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58426	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58427	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCATGCTCAGGGTGGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58428	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58429	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58430	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58431	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58432	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58433	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCGTGGTCCCGAGCCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58434	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58435	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58436	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58437	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58438	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58439	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GACAGGTTACAACAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58440	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58441	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58442	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58443	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58444	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58445	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GGTTCATAAATAATTCAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58446	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58447	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58448	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58449	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58450	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58451	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAGCTTAGCACACAGCGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58452	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58453	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58454	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58455	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58456	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58457	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GACTTCTCCAGGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58458	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58459	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58460	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58461	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58462	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58463	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GCTCTCGTTCCTACCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58464	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58465	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58466	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58467	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58468	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58469	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GGCCCCATCAGGAATTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58470	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58471	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58472	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58473	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58474	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58475	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AACAATCTACCACACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58476	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58477	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58478	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58479	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58480	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58481	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGAAGCTGCAAGGCTCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58482	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58483	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58484	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58485	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58486	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58487	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				TAACGGGCCCAGCTAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58488	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58489	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58490	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58491	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58492	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58493	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCATACACTCCGTCTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58494	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58495	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58496	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58497	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58498	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58499	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CAGGGGTGTCCGTAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58500	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58501	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58502	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58503	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58504	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58505	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGGGGGTTGATATGAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58506	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58507	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58508	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58509	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58510	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58511	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCTCCACTGTGAGTAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58512	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58513	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58514	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58515	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58516	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58517	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAACACAAAATCTCTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58518	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58519	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58520	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58521	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58522	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58523	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				GAAGAAAATCCAAACAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58524	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58525	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58526	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58527	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58528	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58529	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AGCCGCTCCTGCAGTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58530	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58531	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58532	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58533	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58534	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58535	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				AAGACTCATTTCAGAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58536	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58537	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58538	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58539	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58540	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58541	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CGAGTTGTAGGCAGCACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58542	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60935				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58543	hg19	N/A	enh19994	fant60357	N/A	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	60751				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58544	hg19	N/A	enh19994	N/A	N/A	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	59859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58545	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	58031				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58546	hg19	N/A	enh19994	fant60358	Enhatls114871	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	57759				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43097800	43106863	41677640	41686703	58547	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_653				CCCAGCTTGCGGCAGCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58548	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_654				GTGTGACGATCAGGTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58549	hg19	N/A	enh19994	N/A	N/A	enhancer	E_654				GTGTGACGATCAGGTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	50849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58550	hg19	N/A	enh19994	N/A	Enhatls114872	enhancer	E_654				GTGTGACGATCAGGTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	49474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58551	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_654				CTCTGACCCTAAGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58552	hg19	N/A	enh19994	N/A	N/A	enhancer	E_654				CTCTGACCCTAAGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	50849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58553	hg19	N/A	enh19994	N/A	Enhatls114872	enhancer	E_654				CTCTGACCCTAAGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	49474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58554	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_654				CGAACAATCCCCAAACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58555	hg19	N/A	enh19994	N/A	N/A	enhancer	E_654				CGAACAATCCCCAAACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	50849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58556	hg19	N/A	enh19994	N/A	Enhatls114872	enhancer	E_654				CGAACAATCCCCAAACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	49474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58557	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_654				TAATGATCCTGCTCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58558	hg19	N/A	enh19994	N/A	N/A	enhancer	E_654				TAATGATCCTGCTCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	50849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58559	hg19	N/A	enh19994	N/A	Enhatls114872	enhancer	E_654				TAATGATCCTGCTCAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	49474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58560	hg19	N/A	enh19994	N/A	Enhatls114871	enhancer	E_654				CATCAAATGAATTACAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	51049				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58561	hg19	N/A	enh19994	N/A	N/A	enhancer	E_654				CATCAAATGAATTACAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	50849				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107431	chr21	43107894	43108684	41687734	41688524	58562	hg19	N/A	enh19994	N/A	Enhatls114872	enhancer	E_654				CATCAAATGAATTACAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	49474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1314
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58563	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58564	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58565	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58566	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58567	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58568	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				TGGGTGGCCGGTGCTCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58569	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58570	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58571	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58572	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58573	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58574	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				TCAACGTCCGCATTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58575	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58576	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58577	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58578	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58579	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58580	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				GGGGAGACTTCACAGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58581	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58582	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58583	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58584	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58585	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58586	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				GGACTGAGTTACACTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58587	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58588	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58589	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58590	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58591	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58592	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				TTAATGGGACTCTTGATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58593	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58594	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58595	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58596	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58597	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58598	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				AGCCCTATTGGCTCACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58599	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58600	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58601	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58602	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58603	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58604	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				GGGGGGAAGGCCTGCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58605	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58606	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58607	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58608	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58609	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58610	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				GCCCTGGGAGAAATGGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58611	hg19	N/A	enh45228	N/A	N/A	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58612	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58613	hg19	N/A	enh45228	fant60360	Enhatls114878	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58614	hg19	N/A	enh45228	N/A	Enhatls114878	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107437	chr21	43170272	43177057	41750112	41756897	58615	hg19	N/A	N/A	N/A	Enhatls114878	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1320
enhrx-107438	chr21	43170272	43177057	41750112	41756897	58616	hg19	N/A	N/A	N/A	Enhatls114879	enhancer	E_657				CCCGACCCTGCAAACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					RIPK4	chr21	41739368	41767089	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1321
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58617	hg19	N/A	enh53879	N/A	N/A	enhancer	E_659				TTAGCTTGACCTAAACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	1908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58618	hg19	N/A	enh53879	N/A	Enhatls114925	enhancer	E_659				TTAGCTTGACCTAAACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	4874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58619	hg19	N/A	enh53879	N/A	N/A	enhancer	E_659				GCTTCCTCCTTCCCGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	1908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58620	hg19	N/A	enh53879	N/A	Enhatls114925	enhancer	E_659				GCTTCCTCCTTCCCGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	4874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58621	hg19	N/A	enh53879	N/A	N/A	enhancer	E_659				TGGAGATGAGAATTGTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	1908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58622	hg19	N/A	enh53879	N/A	Enhatls114925	enhancer	E_659				TGGAGATGAGAATTGTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	4874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58623	hg19	N/A	enh53879	N/A	N/A	enhancer	E_659				ACAGCTTTGAGGCAGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	1908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58624	hg19	N/A	enh53879	N/A	Enhatls114925	enhancer	E_659				ACAGCTTTGAGGCAGGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	4874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58625	hg19	N/A	enh53879	N/A	N/A	enhancer	E_659				ACAGCATCCCAGAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	1908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107481	chr21	43375209	43379540	41955100	41959431	58626	hg19	N/A	enh53879	N/A	Enhatls114925	enhancer	E_659				ACAGCATCCCAGAACCTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					C2CD2	chr21	41885111	41954018	4874				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1364
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58627	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GCCTTCACAACTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58628	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				GCCTTCACAACTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58629	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GCCTTCACAACTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58630	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				AAACCCAGCAATGAGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58631	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				AAACCCAGCAATGAGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58632	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				AAACCCAGCAATGAGGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58633	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GTCTGTTCAGCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58634	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				GTCTGTTCAGCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58635	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GTCTGTTCAGCAGCTGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58636	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				ACATCAACTCAGAACATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58637	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				ACATCAACTCAGAACATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58638	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				ACATCAACTCAGAACATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58639	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GGTCGTGAGTGACAGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58640	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				GGTCGTGAGTGACAGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58641	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				GGTCGTGAGTGACAGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58642	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CAAGTCCCTGTTTTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58643	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				CAAGTCCCTGTTTTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58644	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CAAGTCCCTGTTTTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58645	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CCGACCCTAATGATGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58646	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				CCGACCCTAATGATGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58647	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CCGACCCTAATGATGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58648	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				TGCGTGGTTGAGTCCTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58649	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				TGCGTGGTTGAGTCCTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58650	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				TGCGTGGTTGAGTCCTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58651	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CATCATACCCCTCATCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58652	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				CATCATACCCCTCATCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58653	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CATCATACCCCTCATCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58654	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CTAAACATCACACTCATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58655	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				CTAAACATCACACTCATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58656	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CTAAACATCACACTCATGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58657	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				ATGTGCTTTTGCTTACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58658	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				ATGTGCTTTTGCTTACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58659	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				ATGTGCTTTTGCTTACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58660	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				AAGCAGTGTGGACTGAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58661	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				AAGCAGTGTGGACTGAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58662	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				AAGCAGTGTGGACTGAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58663	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CTTGGGCAAGAGCGATGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	22455				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58664	hg19	N/A	enh20001	fant60370	Enhatls114931	enhancer	E_660				CTTGGGCAAGAGCGATGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	21980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107488	chr21	43459403	43461869	42039294	42041760	58665	hg19	N/A	enh20001	N/A	Enhatls114931	enhancer	E_660				CTTGGGCAAGAGCGATGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	14643				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1371
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58666	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				TTTTTCCGGATGACTGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58667	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				GTTCACTGTGCCAAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58668	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				CGACCGCCAAACACAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58669	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				GTTCAGCAGGGAAGGTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58670	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				TGTCAGACGTGGAGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107496	chr21	43513366	43514865	42093256	42094755	58671	hg19	N/A	enh82371	N/A	Enhatls114938	enhancer	E_661				GTTTGTATGACCCAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					UMODL1	chr21	42062958	42143453	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1379
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58672	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				CAAACAACGGTGCATAAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58673	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				TTGGGGAAGGCTCTCCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58674	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				ACCGCTTGCTGCCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58675	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				GCTCTCTTGTCATGGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58676	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				CTGAGTGAGTCAGGACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58677	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				ATGTAGTTACTAATTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-107521	chr21	43734965	43738042	42314855	42317932	58678	hg19	N/A	N/A	N/A	Enhatls114967	enhancer	E_662				AAAATATGTTAGTAAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFF3	direct	Highly Significant	NA					TFF3	chr21	42311666	42315409	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1404
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58679	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				CCAGTGAGGCAGCGATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58680	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				CCAGTGAGGCAGCGATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58681	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				CCAGTGAGGCAGCGATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58682	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				CCAGTGAGGCAGCGATGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58683	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				TCACTGGAAGAGCCCCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58684	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				TCACTGGAAGAGCCCCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58685	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				TCACTGGAAGAGCCCCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58686	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				TCACTGGAAGAGCCCCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58687	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				AGCCCCGATGCTAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58688	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				AGCCCCGATGCTAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58689	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				AGCCCCGATGCTAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58690	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				AGCCCCGATGCTAGCTACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58691	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				CTTAACTTATGACTCAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58692	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				CTTAACTTATGACTCAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58693	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				CTTAACTTATGACTCAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58694	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				CTTAACTTATGACTCAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58695	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				TTCCGCCTTGAGCAGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58696	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				TTCCGCCTTGAGCAGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58697	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				TTCCGCCTTGAGCAGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58698	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				TTCCGCCTTGAGCAGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58699	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				TCAGGAGGTCAAAACCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58700	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				TCAGGAGGTCAAAACCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58701	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				TCAGGAGGTCAAAACCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58702	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				TCAGGAGGTCAAAACCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58703	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				CGGGGCTCCAGCCGTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58704	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				CGGGGCTCCAGCCGTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58705	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				CGGGGCTCCAGCCGTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58706	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				CGGGGCTCCAGCCGTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58707	hg19	N/A	enh91395	N/A	Enhatls116111	enhancer	E_669				AGAGCGCAATGGTACGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108569	chr22	20048161	20052124	20060638	20064601	58708	hg19	N/A	N/A	N/A	Enhatls116111	enhancer	E_669				AGAGCGCAATGGTACGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	400
enhrx-108570	chr22	20048161	20052124	20060638	20064601	58709	hg19	N/A	N/A	N/A	Enhatls116112	enhancer	E_669				AGAGCGCAATGGTACGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	401
enhrx-108571	chr22	20048161	20052124	20060638	20064601	58710	hg19	N/A	N/A	N/A	Enhatls116113	enhancer	E_669				AGAGCGCAATGGTACGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					TANGO2	chr22	20017013	20067164	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	402
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58711	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				AGGCCTCCTGGAATGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58712	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				AGGCCTCCTGGAATGGACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58713	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				GCATTGCAGGAGTCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58714	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				GCATTGCAGGAGTCCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58715	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				GCCTAGGAAACACTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58716	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				GCCTAGGAAACACTGCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58717	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				ACGGGCGCCTGGATGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58718	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				ACGGGCGCCTGGATGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58719	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				GTCGCGTCCCACAACCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58720	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				GTCGCGTCCCACAACCACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58721	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				GGAGGAGTGAACTCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58722	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				GGAGGAGTGAACTCCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58723	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				CAGCAGGGATAGCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58724	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				CAGCAGGGATAGCCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58725	hg19	N/A	enh6722	N/A	N/A	enhancer	E_672				GAGGGACTACTGCCCATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108597	chr22	20229342	20231228	20241819	20243705	58726	hg19	N/A	enh6722	N/A	Enhatls116141	enhancer	E_672				GAGGGACTACTGCCCATGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED15	direct	Highly Significant	NA					RTN4R	chr22	20241414	20268318	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	428
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58727	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GATGGGTGACCCCTCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58728	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GATGGGTGACCCCTCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58729	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GATGGGTGACCCCTCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58730	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GATGGGTGACCCCTCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58731	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GGTCTCACGCTGGCAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58732	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GGTCTCACGCTGGCAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58733	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GGTCTCACGCTGGCAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58734	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GGTCTCACGCTGGCAACTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58735	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				TCAGAAGATCCTGGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58736	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				TCAGAAGATCCTGGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58737	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				TCAGAAGATCCTGGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58738	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				TCAGAAGATCCTGGCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58739	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GAGAACAAGAAGAGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58740	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GAGAACAAGAAGAGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58741	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GAGAACAAGAAGAGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58742	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GAGAACAAGAAGAGGCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58743	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				TGAGGGTCTGCGGCTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58744	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				TGAGGGTCTGCGGCTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58745	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				TGAGGGTCTGCGGCTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58746	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				TGAGGGTCTGCGGCTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58747	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GCCGGGTCTGGCTTGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58748	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GCCGGGTCTGGCTTGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58749	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GCCGGGTCTGGCTTGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58750	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GCCGGGTCTGGCTTGGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58751	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				ACCTTCCGCAGTAGCAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58752	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				ACCTTCCGCAGTAGCAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58753	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				ACCTTCCGCAGTAGCAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58754	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				ACCTTCCGCAGTAGCAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58755	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				ACCCGTTGAGGCAGACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58756	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				ACCCGTTGAGGCAGACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58757	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				ACCCGTTGAGGCAGACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58758	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				ACCCGTTGAGGCAGACAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58759	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				AGTAAGCGCCCGCGGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58760	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				AGTAAGCGCCCGCGGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58761	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				AGTAAGCGCCCGCGGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58762	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				AGTAAGCGCCCGCGGCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58763	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GGGGAAAAGGCCGGGATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58764	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GGGGAAAAGGCCGGGATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58765	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GGGGAAAAGGCCGGGATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58766	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GGGGAAAAGGCCGGGATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58767	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				ATTCTGGACTGGTCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58768	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				ATTCTGGACTGGTCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58769	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				ATTCTGGACTGGTCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58770	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				ATTCTGGACTGGTCACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58771	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				GTCCCGGGAGACCCACGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58772	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				GTCCCGGGAGACCCACGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58773	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				GTCCCGGGAGACCCACGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58774	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				GTCCCGGGAGACCCACGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58775	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				CACATAAAGTTACTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58776	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				CACATAAAGTTACTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58777	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				CACATAAAGTTACTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58778	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				CACATAAAGTTACTTCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58779	hg19	"hs1620,hs2815"	enh34990	N/A	Enhatls116186	enhancer	E_673				AGGGCTGCTCCCCCCTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58780	hg19	hs1620	enh34990	N/A	N/A	enhancer	E_673				AGGGCTGCTCCCCCCTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108612	chr22	20775763	20780942	20421473	20426655	58781	hg19	N/A	enh34990	N/A	N/A	enhancer	E_673				AGGGCTGCTCCCCCCTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	443
enhrx-108613	chr22	20775763	20780942	20421473	20426655	58782	hg19	N/A	N/A	N/A	Enhatls116187	enhancer	E_673				AGGGCTGCTCCCCCCTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					SCARF2	chr22	20424583	20437826	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58783	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58784	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58785	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58786	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58787	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58788	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58789	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58790	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58791	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58792	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58793	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58794	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58795	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58796	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58797	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58798	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58799	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58800	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58801	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58802	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58803	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58804	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58805	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58806	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58807	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58808	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58809	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58810	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58811	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58812	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58813	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58814	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58815	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58816	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58817	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58818	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58819	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58820	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58821	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58822	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58823	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58824	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58825	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58826	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58827	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58828	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58829	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58830	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58831	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58832	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58833	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58834	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58835	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58836	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58837	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58838	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58839	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58840	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58841	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58842	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58843	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58844	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58845	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58846	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58847	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58848	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58849	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58850	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58851	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58852	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58853	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58854	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58855	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58856	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58857	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58858	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58859	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58860	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58861	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58862	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58863	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58864	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58865	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58866	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58867	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58868	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58869	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58870	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58871	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58872	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58873	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58874	hg19	N/A	N/A	fant60724	Enhatls116202	enhancer	E_674				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58875	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58876	hg19	N/A	N/A	fant60725	Enhatls116202	enhancer	E_674				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-108628	chr22	20848531	20850391	20494244	20496104	58877	hg19	N/A	N/A	N/A	Enhatls116202	enhancer	E_674				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					KLHL22	chr22	20441518	20495823	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	459
enhrx-lit781	chr22	20850857	20851309	20496570	20497022	58878	hg19					enhancer	E_675				GCGGGCGGCCTTGCAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit782	chr22	20850857	20851309	20496570	20497022	58879	hg19					enhancer	E_675				GGGCCCGCCCGGGTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit783	chr22	20850857	20851309	20496570	20497022	58880	hg19					enhancer	E_675				GTCCCCGCCACGTCAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit784	chr22	20850857	20851309	20496570	20497022	58881	hg19					enhancer	E_675				CCGGGGACAAGCTAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit785	chr22	20850857	20851309	20496570	20497022	58882	hg19					enhancer	E_675				CCGGGCGGCAGCGAACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit786	chr22	20850857	20851309	20496570	20497022	58883	hg19					enhancer	E_675				CCTGGTGCCGCCGCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit787	chr22	20850857	20851309	20496570	20497022	58884	hg19					enhancer	E_675				TGGGTGCGCCGCGCAGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit788	chr22	20850857	20851309	20496570	20497022	58885	hg19					enhancer	E_675				TGCTGTCCTCCGCAGAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit789	chr22	20850857	20851309	20496570	20497022	58886	hg19					enhancer	E_675				GCGGCACCTGGCACTTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit790	chr22	20850857	20851309	20496570	20497022	58887	hg19					enhancer	E_675				GAGGGAGGATATGAGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit791	chr22	20850857	20851309	20496570	20497022	58888	hg19					enhancer	E_675				AATGGTGGGTAAGATAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit792	chr22	20850857	20851309	20496570	20497022	58889	hg19					enhancer	E_675				GAGAGAACGAGAGTTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit793	chr22	20850857	20851309	20496570	20497022	58890	hg19					enhancer	E_675				AATGGGAGAAGAGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit794	chr22	20850857	20851309	20496570	20497022	58891	hg19					enhancer	E_675				GGGAATGAGCGCGTGACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit795	chr22	20850857	20851309	20496570	20497022	58892	hg19					enhancer	E_675				AGGGGGCGCGCTACGGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit796	chr22	20850857	20851309	20496570	20497022	58893	hg19					enhancer	E_675				CTAGCACCTGTTCACTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit797	chr22	20850857	20851309	20496570	20497022	58894	hg19					enhancer	E_675				TGAATGCCAAGACCCGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit798	chr22	20850857	20851309	20496570	20497022	58895	hg19					enhancer	E_675				CGAGCAGGTCCCATCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit799	chr22	20850857	20851309	20496570	20497022	58896	hg19					enhancer	E_675				GCCTCCTGATGGGATAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58897	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CAAGGACAGTAAAAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58898	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CAAGGACAGTAAAAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58899	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CAAGGACAGTAAAAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58900	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CAAGGACAGTAAAAGCACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58901	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CATCTTCCCATACTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58902	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CATCTTCCCATACTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58903	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CATCTTCCCATACTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58904	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CATCTTCCCATACTCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58905	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AACTAGCCCTTCTCTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58906	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AACTAGCCCTTCTCTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58907	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AACTAGCCCTTCTCTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58908	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AACTAGCCCTTCTCTTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58909	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AGCTCTGCCTATGAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58910	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGCTCTGCCTATGAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58911	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AGCTCTGCCTATGAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58912	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGCTCTGCCTATGAATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58913	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AAGGGGAATGAGGGACATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58914	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AAGGGGAATGAGGGACATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58915	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AAGGGGAATGAGGGACATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58916	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AAGGGGAATGAGGGACATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58917	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AGAAGAAGCAAGGGGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58918	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGAAGAAGCAAGGGGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58919	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AGAAGAAGCAAGGGGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58920	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGAAGAAGCAAGGGGTACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58921	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				TGGGTGAAAGCAGTGCTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58922	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TGGGTGAAAGCAGTGCTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58923	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				TGGGTGAAAGCAGTGCTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58924	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TGGGTGAAAGCAGTGCTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58925	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				TGAGTTCTACTTCACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58926	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TGAGTTCTACTTCACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58927	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				TGAGTTCTACTTCACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58928	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TGAGTTCTACTTCACAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58929	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CTACTACAGAGCACTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58930	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTACTACAGAGCACTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58931	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CTACTACAGAGCACTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58932	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTACTACAGAGCACTTGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58933	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GCGTGTCGTTCACTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58934	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCGTGTCGTTCACTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58935	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GCGTGTCGTTCACTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58936	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCGTGTCGTTCACTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58937	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GGGGAGTATCAACAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58938	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GGGGAGTATCAACAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58939	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GGGGAGTATCAACAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58940	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GGGGAGTATCAACAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58941	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CATGTTGATGAGGCATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58942	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CATGTTGATGAGGCATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58943	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CATGTTGATGAGGCATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58944	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CATGTTGATGAGGCATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58945	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GTCACCTGCAGTGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58946	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTCACCTGCAGTGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58947	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GTCACCTGCAGTGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58948	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTCACCTGCAGTGTACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58949	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				ATAACCTCAACACATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58950	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				ATAACCTCAACACATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58951	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				ATAACCTCAACACATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58952	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				ATAACCTCAACACATGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58953	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CTGGACATACAGGAAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58954	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGACATACAGGAAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58955	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CTGGACATACAGGAAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58956	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGACATACAGGAAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58957	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CGACCTCACGGGTAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58958	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CGACCTCACGGGTAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58959	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CGACCTCACGGGTAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58960	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CGACCTCACGGGTAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58961	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AGACCGGGGCAGCTTGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58962	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGACCGGGGCAGCTTGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58963	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AGACCGGGGCAGCTTGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58964	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AGACCGGGGCAGCTTGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58965	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CTGGCAAACTGAGCTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58966	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGCAAACTGAGCTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58967	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CTGGCAAACTGAGCTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58968	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGCAAACTGAGCTTCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58969	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CTCATTCAGATTACAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58970	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTCATTCAGATTACAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58971	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CTCATTCAGATTACAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58972	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTCATTCAGATTACAAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58973	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GCAGGGCTTCTGCCCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58974	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCAGGGCTTCTGCCCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58975	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GCAGGGCTTCTGCCCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58976	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCAGGGCTTCTGCCCAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58977	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				AAGAGGTTACGCTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58978	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AAGAGGTTACGCTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58979	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				AAGAGGTTACGCTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58980	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				AAGAGGTTACGCTTTAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58981	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				CTGGGAGAAGGCGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58982	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGGAGAAGGCGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58983	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				CTGGGAGAAGGCGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58984	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				CTGGGAGAAGGCGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58985	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GGGGAATCCAGGCCTCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58986	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GGGGAATCCAGGCCTCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58987	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GGGGAATCCAGGCCTCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58988	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GGGGAATCCAGGCCTCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58989	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GTACTGTCATGCATTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58990	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTACTGTCATGCATTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58991	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GTACTGTCATGCATTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58992	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTACTGTCATGCATTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58993	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GCGTCCACTTTTGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58994	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCGTCCACTTTTGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58995	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GCGTCCACTTTTGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58996	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GCGTCCACTTTTGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	direct	Highly Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58997	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				ATGTCTGTGGCACTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58998	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				ATGTCTGTGGCACTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	58999	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				ATGTCTGTGGCACTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59000	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				ATGTCTGTGGCACTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59001	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				GTAGTAGGTCATCATCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59002	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTAGTAGGTCATCATCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59003	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				GTAGTAGGTCATCATCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59004	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				GTAGTAGGTCATCATCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59005	hg19	N/A	N/A	N/A	Enhatls116204	enhancer	E_676				TCCTCAGTGGGCTCCTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59006	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TCCTCAGTGGGCTCCTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59007	hg19	N/A	enh20070	fant60727	Enhatls116204	enhancer	E_676				TCCTCAGTGGGCTCCTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108630	chr22	20871811	20888166	20517524	20533879	59008	hg19	N/A	enh20070	N/A	Enhatls116204	enhancer	E_676				TCCTCAGTGGGCTCCTGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"CRKL,MED15"	indirect	Non Significant	NA					MED15	chr22	20495912	20587632	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	461
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59009	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59010	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59011	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59012	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59013	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59014	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59015	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59016	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59017	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59018	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59019	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59020	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59021	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59022	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59023	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59024	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59025	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59026	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TCTCCCAGTGTTGGGATTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59027	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59028	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59029	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59030	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59031	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59032	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59033	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59034	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59035	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59036	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59037	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59038	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59039	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59040	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59041	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59042	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59043	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59044	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TGACTCAGACAGGTAATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59045	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59046	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59047	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59048	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59049	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59050	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59051	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59052	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59053	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59054	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59055	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59056	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59057	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59058	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59059	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59060	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59061	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59062	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CCAGAGTGCAGTTAATAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59063	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59064	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59065	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59066	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59067	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59068	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59069	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59070	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59071	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59072	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59073	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59074	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59075	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59076	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59077	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59078	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59079	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59080	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TGTTCCTCTGACTCGTTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59081	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59082	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59083	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59084	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59085	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59086	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59087	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59088	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59089	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59090	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59091	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59092	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59093	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59094	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59095	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59096	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59097	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59098	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AAATAAAGGGAGTGCCCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59099	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59100	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59101	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59102	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59103	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59104	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59105	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59106	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59107	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59108	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59109	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59110	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59111	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59112	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59113	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59114	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59115	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59116	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TTAGTTGCTCCTGACAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59117	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59118	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59119	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59120	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59121	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59122	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59123	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59124	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59125	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59126	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59127	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59128	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59129	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59130	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59131	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59132	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59133	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59134	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGCGTAGTGAGGTGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59135	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59136	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59137	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59138	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59139	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59140	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59141	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59142	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59143	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59144	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59145	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59146	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59147	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59148	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59149	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59150	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59151	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59152	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GCGAGTTAGGTGCCTTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59153	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59154	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59155	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59156	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59157	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59158	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59159	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59160	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59161	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59162	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59163	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59164	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59165	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59166	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59167	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59168	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59169	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59170	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TAACAAGAGAGGTTAACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59171	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59172	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59173	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59174	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59175	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59176	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59177	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59178	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59179	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59180	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59181	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59182	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59183	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59184	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59185	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59186	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59187	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59188	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGGTGAGACGATTTCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59189	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59190	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59191	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59192	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59193	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59194	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59195	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59196	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59197	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59198	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59199	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59200	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59201	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59202	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59203	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59204	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59205	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59206	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CTGGGTGAATAAATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	indirect	Non Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59207	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59208	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59209	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59210	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59211	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59212	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59213	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59214	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59215	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59216	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59217	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59218	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59219	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59220	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59221	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59222	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59223	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59224	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CTTCCGGCTGAATGAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59225	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59226	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59227	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59228	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59229	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59230	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59231	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59232	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59233	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59234	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59235	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59236	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59237	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59238	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59239	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59240	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59241	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59242	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				CCTCCAGCTGGAATACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59243	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59244	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59245	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59246	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59247	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59248	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59249	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59250	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59251	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59252	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59253	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59254	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59255	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59256	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59257	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59258	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59259	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59260	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AGCGCAACTGACACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59261	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59262	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59263	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59264	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59265	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59266	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59267	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59268	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59269	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59270	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59271	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59272	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59273	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59274	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59275	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59276	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59277	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59278	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				TTTGAGCTCCCAGATGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59279	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59280	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59281	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59282	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59283	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59284	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59285	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59286	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59287	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59288	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59289	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59290	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59291	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59292	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59293	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59294	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59295	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59296	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGCCCTGTATGGAAGTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59297	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59298	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59299	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59300	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59301	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59302	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59303	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59304	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59305	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59306	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59307	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59308	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59309	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59310	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59311	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59312	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59313	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59314	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				GGGCCAGTTTCAGAAGTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59315	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59316	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59317	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59318	hg19	N/A	enh76787	fant60735	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59319	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59320	hg19	N/A	enh76787	N/A	Enhatls116257	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59321	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59322	hg19	N/A	enh76787	N/A	N/A	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59323	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59324	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59325	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59326	hg19	N/A	enh76787	fant60736	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59327	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59328	hg19	N/A	enh76787	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59329	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108670	chr22	21131599	21139031	20777311	20784743	59330	hg19	N/A	N/A	N/A	Enhatls116258	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59331	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					PI4KA	chr22	20707690	20859417	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108671	chr22	21131599	21139031	20777311	20784743	59332	hg19	N/A	N/A	N/A	Enhatls116259	enhancer	E_677				AATGGAATTATACCCATTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"MAPK1,CRKL,MED15"	direct	Highly Significant	NA					SERPIND1	chr22	20774112	20787720	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	502
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59333	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AAGTGGAGGCGACCTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59334	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				AAGTGGAGGCGACCTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59335	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AAGTGGAGGCGACCTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59336	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				AAGTGGAGGCGACCTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59337	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AAGTGGAGGCGACCTCGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59338	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				ACGTTTCTCTCAACTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59339	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				ACGTTTCTCTCAACTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59340	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				ACGTTTCTCTCAACTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59341	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				ACGTTTCTCTCAACTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59342	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				ACGTTTCTCTCAACTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59343	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				TCTGCTAGATGGGGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59344	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				TCTGCTAGATGGGGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59345	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				TCTGCTAGATGGGGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59346	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				TCTGCTAGATGGGGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59347	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				TCTGCTAGATGGGGGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59348	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTCTTTGCCGGTTCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59349	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GCTCTTTGCCGGTTCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59350	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTCTTTGCCGGTTCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59351	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GCTCTTTGCCGGTTCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59352	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTCTTTGCCGGTTCAATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59353	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGGAGGTCAGGCTCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59354	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GGGGAGGTCAGGCTCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59355	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGGAGGTCAGGCTCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59356	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GGGGAGGTCAGGCTCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59357	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGGAGGTCAGGCTCCGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59358	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTGGTGGCCCGCGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59359	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GCTGGTGGCCCGCGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59360	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTGGTGGCCCGCGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59361	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GCTGGTGGCCCGCGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59362	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GCTGGTGGCCCGCGTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59363	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGTAGGGATCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59364	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GGGTAGGGATCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59365	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGTAGGGATCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59366	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GGGTAGGGATCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59367	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGGTAGGGATCCCGGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59368	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AATAGGCCTAGGGGTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59369	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				AATAGGCCTAGGGGTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59370	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AATAGGCCTAGGGGTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59371	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				AATAGGCCTAGGGGTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59372	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AATAGGCCTAGGGGTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59373	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCCGACCTGCGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59374	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				CCCGACCTGCGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59375	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCCGACCTGCGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59376	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				CCCGACCTGCGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59377	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCCGACCTGCGCATTCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59378	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCACGGAGACCGGGCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59379	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				CCACGGAGACCGGGCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59380	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCACGGAGACCGGGCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59381	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				CCACGGAGACCGGGCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59382	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CCACGGAGACCGGGCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59383	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GACGTGCCCGCGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59384	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GACGTGCCCGCGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59385	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GACGTGCCCGCGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59386	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GACGTGCCCGCGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59387	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GACGTGCCCGCGAGGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59388	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GAGCTAGCGGAGCCGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59389	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GAGCTAGCGGAGCCGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59390	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GAGCTAGCGGAGCCGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59391	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GAGCTAGCGGAGCCGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59392	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GAGCTAGCGGAGCCGGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59393	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGAGGACGCCCGGGAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59394	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				GGAGGACGCCCGGGAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59395	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGAGGACGCCCGGGAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59396	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				GGAGGACGCCCGGGAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59397	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				GGAGGACGCCCGGGAAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59398	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AACATTGTAACCGCCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59399	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				AACATTGTAACCGCCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59400	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AACATTGTAACCGCCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59401	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				AACATTGTAACCGCCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59402	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				AACATTGTAACCGCCGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59403	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CTGGCTAACACAGTGAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	52063				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59404	hg19	N/A	enh20086	fant60794	Enhatls116539	enhancer	E_678				CTGGCTAACACAGTGAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51761				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59405	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CTGGCTAACACAGTGAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	51390				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59406	hg19	N/A	enh20086	fant60795	Enhatls116539	enhancer	E_678				CTGGCTAACACAGTGAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	50980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108927	chr22	23860515	23867199	23518328	23525012	59407	hg19	N/A	enh20086	N/A	Enhatls116539	enhancer	E_678				CTGGCTAACACAGTGAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					IGLL1	chr22	23573124	23580302	46281				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	758
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59408	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				TGGTCACAGAAACATAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59409	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GCATGGAGGAATCCAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59410	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				TCACGCAATGGATCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59411	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				AGAGCGCTCCGAAGACTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59412	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				ACACACACACACTTTGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59413	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GCATAGATGTGCACAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59414	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				CAGGGAATCGCGCAGGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59415	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GGCCAGAGCCGGAATTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59416	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				ACTTGCGAGGGCGAATGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59417	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				TTAGCCGAGTAAGGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59418	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				TGCGTCCGAGGCCGTAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59419	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GACTCCCCCCCAACACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59420	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GAGCCGCTAGAGTGTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59421	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				AGAGCGGCCGCACCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59422	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				CTAGCGCCTCTTTCACCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59423	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				GCGTGGAGCATTCGAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59424	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				TCATCTGAAACGCCTGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-108984	chr22	24198571	24201841	23856384	23859654	59425	hg19	N/A	N/A	N/A	Enhatls116602	enhancer	E_679				ACTTAGTTAAGCCTCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					SLC2A11	chr22	23856702	23886312	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	815
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59426	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_680				CAAACTATCTTAAACTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59427	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_680				CAAACTATCTTAAACTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59428	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_680				GCATTGATCAAGTACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59429	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_680				GCATTGATCAAGTACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59430	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_680				ATGAATTTGTAAAAACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59431	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_680				ATGAATTTGTAAAAACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59432	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_680				GAGACATGTGTGCTAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878150	24878643	24482182	24482675	59433	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_680				GAGACATGTGTGCTAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59434	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_681				CAAACTATCTTAAACTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59435	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_681				CAAACTATCTTAAACTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	8726				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59436	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_681				GCATTGATCAAGTACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59437	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_681				GCATTGATCAAGTACTTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	8726				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59438	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_681				ATGAATTTGTAAAAACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59439	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_681				ATGAATTTGTAAAAACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	8726				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59440	hg19	N/A	enh6791	fant60828	Enhatls116716	enhancer	E_681				GAGACATGTGTGCTAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	12145				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109073	chr22	24878656	24879092	24482688	24483124	59441	hg19	N/A	enh6791	N/A	Enhatls116716	enhancer	E_681				GAGACATGTGTGCTAACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	8726				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	904
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59442	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCTGGTGCGGCCACACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59443	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				CCTGGTGCGGCCACACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59444	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCTGGTGCGGCCACACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59445	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				CCTGGTGCGGCCACACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59446	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCTGGTGCGGCCACACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59447	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TCTAGGCTGGCAGTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59448	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				TCTAGGCTGGCAGTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59449	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TCTAGGCTGGCAGTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59450	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				TCTAGGCTGGCAGTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59451	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TCTAGGCTGGCAGTTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59452	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACTACAGTTCTTCAACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59453	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				ACTACAGTTCTTCAACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59454	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACTACAGTTCTTCAACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59455	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				ACTACAGTTCTTCAACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59456	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACTACAGTTCTTCAACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59457	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACACTTTCAAAAGAAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59458	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				ACACTTTCAAAAGAAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59459	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACACTTTCAAAAGAAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59460	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				ACACTTTCAAAAGAAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59461	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				ACACTTTCAAAAGAAGGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59462	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				AAAGAAGCTGCTTATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59463	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				AAAGAAGCTGCTTATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59464	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				AAAGAAGCTGCTTATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59465	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				AAAGAAGCTGCTTATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59466	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				AAAGAAGCTGCTTATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59467	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCACCATCTTGCCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59468	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				CCACCATCTTGCCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59469	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCACCATCTTGCCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59470	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				CCACCATCTTGCCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59471	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				CCACCATCTTGCCAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59472	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TGGGACCGGAAGGAATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59473	hg19	N/A	enh6792	fant60830	Enhatls116719	enhancer	E_682				TGGGACCGGAAGGAATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59474	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TGGGACCGGAAGGAATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59475	hg19	N/A	enh6792	fant60831	Enhatls116719	enhancer	E_682				TGGGACCGGAAGGAATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109074	chr22	24902622	24903831	24506654	24507863	59476	hg19	N/A	enh6792	N/A	Enhatls116719	enhancer	E_682				TGGGACCGGAAGGAATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					UPB1	chr22	24495241	24528390	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	905
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59477	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				TTTTTGTTTTCTTCTGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59478	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				TCAGAGGATCCCTTGAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59479	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				CCAGAGCCTAGCAAACAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59480	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				GCAGTGGGAGAGCTCTATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59481	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				ATTGGACACTCCTAGACTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59482	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				GTGATAGTGTAGTTTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109084	chr22	24945432	24953069	24549464	24557101	59483	hg19	N/A	N/A	N/A	Enhatls116731	enhancer	E_683				GAGTGAGAGGGATTAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SMARCB1	direct	Highly Significant	NA					GUCD1	chr22	24540422	24555935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	915
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59484	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				AGCAATTTGGAAGGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59485	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				AGCAATTTGGAAGGTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59486	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				AAACATCTAGAGCCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59487	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				AAACATCTAGAGCCAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59488	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				GCTGGCCAAGAGTATGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59489	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				GCTGGCCAAGAGTATGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59490	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				CTCCACCTCAGGCCGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59491	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				CTCCACCTCAGGCCGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59492	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				AGAGCGGGATCCGAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59493	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				AGAGCGGGATCCGAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59494	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				GCGAGACGAGGAGGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59495	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				GCGAGACGAGGAGGCTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59496	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				AGCGGCCTCCCTCTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59497	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				AGCGGCCTCCCTCTGAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59498	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				ACTGCGCGAGGTCCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59499	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				ACTGCGCGAGGTCCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59500	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				GCGGACGGTGAGGAGCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59501	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				GCGGACGGTGAGGAGCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59502	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				CCTGCCCGCGCCCGCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59503	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				CCTGCCCGCGCCCGCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59504	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				ACTGGGCTGCGAAGCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59505	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				ACTGGGCTGCGAAGCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59506	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				AGTCGAGCTGAGGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59507	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				AGTCGAGCTGAGGTTCGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59508	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				GTCTGGGTGCCCCCTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59509	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				GTCTGGGTGCCCCCTCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59510	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				TAATGGAAGACAGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59511	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				TAATGGAAGACAGATTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109372	chr22	29167569	29170003	28771581	28774015	59512	hg19	N/A	N/A	N/A	Enhatls117044	enhancer	E_684				GTACAAATCACAGGTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1203
enhrx-109373	chr22	29167569	29170003	28771581	28774015	59513	hg19	N/A	N/A	N/A	Enhatls117045	enhancer	E_684				GTACAAATCACAGGTCAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					CCDC117	chr22	28772673	28789301	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1204
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59514	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				GTTCTCCCATGGTTTAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59515	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				CAGGGGGAATAAAAAACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59516	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				CCCTGCATCCAATAAATATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59517	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				CCAGCCTCTCCAGAGAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59518	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				ACTCATCGCACCTCCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59519	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				ATGAGAGAAAGAGGGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59520	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				TTGTTTTATGAGCCCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59521	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				GCAGGGACTAAGCTGCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59522	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				GGAAAACAGCCAAGCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59523	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				TGTTGAAAACCCACGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59524	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				AGGCATTCGGAAAAGCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109385	chr22	29383631	29386632	28987643	28990644	59525	hg19	N/A	enh20117	N/A	Enhatls117057	enhancer	E_685				GTACTTACAGACAATGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1216
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59526	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				GGGTAATTTGTACTAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59527	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GGGTAATTTGTACTAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59528	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				GGGTAATTTGTACTAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59529	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GGGTAATTTGTACTAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59530	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				AACACTCACGAACCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59531	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AACACTCACGAACCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59532	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				AACACTCACGAACCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59533	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AACACTCACGAACCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59534	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				AATCCTGGTGCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59535	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AATCCTGGTGCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59536	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				AATCCTGGTGCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59537	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AATCCTGGTGCCAGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59538	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				AGGACATTCTCGCTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59539	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AGGACATTCTCGCTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59540	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				AGGACATTCTCGCTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59541	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				AGGACATTCTCGCTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59542	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				ACTAAGTGAAGAACTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59543	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				ACTAAGTGAAGAACTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59544	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				ACTAAGTGAAGAACTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59545	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				ACTAAGTGAAGAACTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59546	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				CTCTTGGCGGGTCCTACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59547	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				CTCTTGGCGGGTCCTACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59548	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				CTCTTGGCGGGTCCTACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59549	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				CTCTTGGCGGGTCCTACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59550	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				GAAAAGGGCGGTTAACACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59551	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GAAAAGGGCGGTTAACACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59552	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				GAAAAGGGCGGTTAACACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59553	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GAAAAGGGCGGTTAACACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59554	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				GTCACTGCTGAAATGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59555	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GTCACTGCTGAAATGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59556	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				GTCACTGCTGAAATGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59557	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GTCACTGCTGAAATGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59558	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				ATTAGGGCACCATTGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59559	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				ATTAGGGCACCATTGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59560	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				ATTAGGGCACCATTGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59561	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				ATTAGGGCACCATTGAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59562	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				GCCAAACCTGCACTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59563	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GCCAAACCTGCACTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59564	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				GCCAAACCTGCACTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59565	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				GCCAAACCTGCACTTTCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59566	hg19	N/A	enh20119	N/A	Enhatls117058	enhancer	E_686				CCATCAGTCTTTTAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59567	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				CCATCAGTCTTTTAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59568	hg19	N/A	enh20119	fant60962	N/A	enhancer	E_686				CCATCAGTCTTTTAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109386	chr22	29425942	29429320	29029954	29033332	59569	hg19	N/A	enh20119	N/A	N/A	enhancer	E_686				CCATCAGTCTTTTAGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ZNRF3	chr22	28883571	29057488	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1217
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59570	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GCTGGTGGCTGAATGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59571	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				GCTGGTGGCTGAATGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59572	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GCTGGTGGCTGAATGGGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59573	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GATCCAGGCTTCCTGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59574	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				GATCCAGGCTTCCTGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59575	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GATCCAGGCTTCCTGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59576	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GTCCAGTGTCATTTACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59577	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				GTCCAGTGTCATTTACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59578	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				GTCCAGTGTCATTTACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59579	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TTTCTAAACTCAAGGGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59580	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				TTTCTAAACTCAAGGGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59581	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TTTCTAAACTCAAGGGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59582	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				ATTAAGTCCAAGATGCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59583	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				ATTAAGTCCAAGATGCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59584	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				ATTAAGTCCAAGATGCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59585	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				CAAACGAGCTTTTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59586	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				CAAACGAGCTTTTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59587	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				CAAACGAGCTTTTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59588	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TGTTGGCGCTTAAGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59589	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				TGTTGGCGCTTAAGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59590	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TGTTGGCGCTTAAGTCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59591	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TCGACTGAGTTTCAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59592	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				TCGACTGAGTTTCAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59593	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TCGACTGAGTTTCAGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59594	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TGAGGTGCCTGCATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59595	hg19	N/A	enh20121	fant60965	Enhatls117071	enhancer	E_687				TGAGGTGCCTGCATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109398	chr22	29503427	29506533	29107439	29110545	59596	hg19	N/A	enh20121	N/A	Enhatls117071	enhancer	E_687				TGAGGTGCCTGCATTCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					KREMEN1	chr22	29073034	29168333	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1229
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59597	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				GAAGGCCCAGATTCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59598	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				GAAGGCCCAGATTCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59599	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				GAAGGCCCAGATTCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59600	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				GAAGGCCCAGATTCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59601	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				GAAGGCCCAGATTCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59602	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				GCAGAAGGCCTGCCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59603	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				GCAGAAGGCCTGCCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59604	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				GCAGAAGGCCTGCCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59605	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				GCAGAAGGCCTGCCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59606	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				GCAGAAGGCCTGCCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59607	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				TATCTGCCATAACATCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59608	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				TATCTGCCATAACATCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59609	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				TATCTGCCATAACATCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59610	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				TATCTGCCATAACATCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59611	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				TATCTGCCATAACATCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59612	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				GTACTCAGAGAGCTCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59613	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				GTACTCAGAGAGCTCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59614	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				GTACTCAGAGAGCTCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59615	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				GTACTCAGAGAGCTCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59616	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				GTACTCAGAGAGCTCGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59617	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				CTGGTGTGAAACCAGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59618	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				CTGGTGTGAAACCAGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59619	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				CTGGTGTGAAACCAGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59620	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				CTGGTGTGAAACCAGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59621	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				CTGGTGTGAAACCAGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59622	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				CCGCTGGTGGATGTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59623	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				CCGCTGGTGGATGTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59624	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				CCGCTGGTGGATGTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59625	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				CCGCTGGTGGATGTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59626	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				CCGCTGGTGGATGTCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59627	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				AGCGCACTCAGTGCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59628	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				AGCGCACTCAGTGCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59629	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				AGCGCACTCAGTGCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59630	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				AGCGCACTCAGTGCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59631	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				AGCGCACTCAGTGCCAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59632	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				GGTTGCGTGACTGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59633	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				GGTTGCGTGACTGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59634	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				GGTTGCGTGACTGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59635	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				GGTTGCGTGACTGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59636	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				GGTTGCGTGACTGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109450	chr22	29726957	29732695	29330968	29336706	59637	hg19	N/A	N/A	N/A	Enhatls117124	enhancer	E_688				TTAGATGCTGGTGGCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1281
enhrx-109451	chr22	29726957	29732695	29330968	29336706	59638	hg19	N/A	N/A	N/A	Enhatls117125	enhancer	E_688				TTAGATGCTGGTGGCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1282
enhrx-109452	chr22	29726957	29732695	29330968	29336706	59639	hg19	N/A	N/A	N/A	Enhatls117126	enhancer	E_688				TTAGATGCTGGTGGCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1283
enhrx-109453	chr22	29726957	29732695	29330968	29336706	59640	hg19	N/A	N/A	fant60978	N/A	enhancer	E_688				TTAGATGCTGGTGGCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1284
enhrx-109454	chr22	29726957	29732695	29330968	29336706	59641	hg19	N/A	enh20122	N/A	N/A	enhancer	E_688				TTAGATGCTGGTGGCACCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1285
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59642	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				GATTACAGGTACCTGCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59643	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				GATTACAGGTACCTGCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59644	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				GATTACAGGTACCTGCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59645	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				GATTACAGGTACCTGCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59646	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CACTCCAGCATGGGGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59647	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				CACTCCAGCATGGGGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59648	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CACTCCAGCATGGGGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59649	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				CACTCCAGCATGGGGGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59650	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TTTCAAGAGTCCCTGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59651	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				TTTCAAGAGTCCCTGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59652	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TTTCAAGAGTCCCTGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59653	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				TTTCAAGAGTCCCTGTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59654	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TTCTTCCCAGTCCAGTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59655	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				TTCTTCCCAGTCCAGTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59656	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TTCTTCCCAGTCCAGTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59657	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				TTCTTCCCAGTCCAGTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59658	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CATCACTGTCAGATCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59659	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				CATCACTGTCAGATCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59660	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CATCACTGTCAGATCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59661	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				CATCACTGTCAGATCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59662	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TGGAACGGATTGTTGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59663	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				TGGAACGGATTGTTGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59664	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TGGAACGGATTGTTGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59665	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				TGGAACGGATTGTTGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59666	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				GCCGTTAGCCTGCATATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59667	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				GCCGTTAGCCTGCATATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59668	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				GCCGTTAGCCTGCATATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59669	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				GCCGTTAGCCTGCATATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59670	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TGGTATATCAGCCCAGCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59671	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				TGGTATATCAGCCCAGCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59672	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				TGGTATATCAGCCCAGCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59673	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				TGGTATATCAGCCCAGCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59674	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CACTGCACTCCAGCTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59675	hg19	N/A	enh35037	N/A	Enhatls117131	enhancer	E_689				CACTGCACTCCAGCTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59676	hg19	N/A	enh35037	N/A	N/A	enhancer	E_689				CACTGCACTCCAGCTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109455	chr22	29737639	29742666	29341650	29346677	59677	hg19	N/A	enh35037	N/A	Enhatls117132	enhancer	E_689				CACTGCACTCCAGCTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1286
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59678	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				GGTACCAGGCCTGAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59679	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				TACCGGATGATCCACCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59680	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				CATGTGTGCCCGGGGGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59681	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				TAGTCATCTCCACAGTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59682	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				GCCTGAGGCCCTCTTAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59683	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				TTTGAAGGTCGGAATCCAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59684	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				AGCTTTGTTAGCACTCTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59685	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				GTTGGAAGACGTTGAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109465	chr22	29776020	29777150	29380031	29381161	59686	hg19	N/A	enh6813	N/A	Enhatls117142	enhancer	E_690				ACCATGGCCTCATAGCCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					AP1B1	chr22	29327679	29388583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1296
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59687	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				AAAGGGAGCAAGCTAACGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59688	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				AAAGGGAGCAAGCTAACGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59689	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				AAAGGGAGCAAGCTAACGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59690	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ACACTGCCACATCTTTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59691	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				ACACTGCCACATCTTTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59692	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ACACTGCCACATCTTTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59693	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				TAGAAGCTATGTGGTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59694	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				TAGAAGCTATGTGGTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59695	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				TAGAAGCTATGTGGTGACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59696	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ATTTGGGTAGCATAGGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59697	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				ATTTGGGTAGCATAGGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59698	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ATTTGGGTAGCATAGGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59699	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				CTGGAGAGAACTTAGGTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59700	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				CTGGAGAGAACTTAGGTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59701	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				CTGGAGAGAACTTAGGTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59702	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				GGCAAATAGTTGTTAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59703	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				GGCAAATAGTTGTTAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59704	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				GGCAAATAGTTGTTAAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59705	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				GCATTTTGTAAACTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59706	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				GCATTTTGTAAACTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59707	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				GCATTTTGTAAACTTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59708	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				TAAGCCTCATTTTAAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59709	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				TAAGCCTCATTTTAAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59710	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				TAAGCCTCATTTTAAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59711	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ACACCAGGCTGAATACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59712	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				ACACCAGGCTGAATACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59713	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				ACACCAGGCTGAATACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59714	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				AAAACTGAACTGTCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59715	hg19	N/A	enh20123	fant60984	Enhatls117175	enhancer	E_691				AAAACTGAACTGTCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109497	chr22	30013331	30021405	29617342	29625416	59716	hg19	N/A	enh20123	N/A	Enhatls117175	enhancer	E_691				AAAACTGAACTGTCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					NF2	chr22	29603555	29698598	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1328
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59717	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				CTACTGATAATCCTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59718	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				CTACTGATAATCCTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59719	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				CTACTGATAATCCTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59720	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TACTGCTTTTGTACTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59721	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				TACTGCTTTTGTACTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59722	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TACTGCTTTTGTACTAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59723	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAAGGGCTGACTGAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59724	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GGAAGGGCTGACTGAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59725	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAAGGGCTGACTGAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59726	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AATGAGTTTGAAGTCCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59727	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				AATGAGTTTGAAGTCCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59728	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AATGAGTTTGAAGTCCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59729	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AAATTCCTTGCACAAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59730	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				AAATTCCTTGCACAAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59731	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AAATTCCTTGCACAAGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59732	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				ACGAACACTCTGTACTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59733	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				ACGAACACTCTGTACTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59734	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				ACGAACACTCTGTACTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59735	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GCATGTGCGGCACCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59736	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GCATGTGCGGCACCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59737	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GCATGTGCGGCACCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59738	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GATGCTGACATGTCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59739	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GATGCTGACATGTCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59740	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GATGCTGACATGTCACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59741	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GTGCTTAGCACAGGTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59742	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GTGCTTAGCACAGGTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59743	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GTGCTTAGCACAGGTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59744	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TATTTGATCCACAAAAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59745	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				TATTTGATCCACAAAAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59746	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TATTTGATCCACAAAAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59747	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AAAGCAGCTGGGACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59748	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				AAAGCAGCTGGGACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59749	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				AAAGCAGCTGGGACAATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59750	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAAAGCGATCAGGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59751	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GGAAAGCGATCAGGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59752	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAAAGCGATCAGGCCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59753	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAGAGATAAGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59754	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GGAGAGATAAGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59755	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GGAGAGATAAGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59756	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GTGCAGGCCCCAAACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59757	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				GTGCAGGCCCCAAACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59758	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				GTGCAGGCCCCAAACAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59759	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TAGCCTCTCCTGACTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59760	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				TAGCCTCTCCTGACTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59761	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				TAGCCTCTCCTGACTGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59762	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				CAGGGGAAAGGGAAGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					UQCR10	chr22	29767368	29770413	5704				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59763	hg19	N/A	enh35041	fant60989	Enhatls117201	enhancer	E_692				CAGGGGAAAGGGAAGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	6312				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109524	chr22	30173621	30179211	29777632	29783222	59764	hg19	N/A	enh35041	N/A	Enhatls117201	enhancer	E_692				CAGGGGAAAGGGAAGAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	1306				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1355
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59765	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				AGGGGCTGCAGATTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59766	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				AGGGGCTGCAGATTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59767	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				AGGGGCTGCAGATTGCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59768	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				CATTGAGGTGGCCAGGTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59769	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				CATTGAGGTGGCCAGGTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59770	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				CATTGAGGTGGCCAGGTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59771	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				ACCTACGAGCATTTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59772	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				ACCTACGAGCATTTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59773	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				ACCTACGAGCATTTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59774	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				TTGATCTGTGGTTTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59775	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				TTGATCTGTGGTTTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59776	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				TTGATCTGTGGTTTTGTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59777	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				AGAGATGGCTAATCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59778	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				AGAGATGGCTAATCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59779	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				AGAGATGGCTAATCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59780	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				GTAGCTCCAGCGGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59781	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				GTAGCTCCAGCGGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59782	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				GTAGCTCCAGCGGTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59783	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				ACATCTTTGGCCTGGGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59784	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				ACATCTTTGGCCTGGGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59785	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				ACATCTTTGGCCTGGGATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59786	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				AGGGCAACTACAAAGCCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59787	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				AGGGCAACTACAAAGCCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59788	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				AGGGCAACTACAAAGCCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59789	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				GCCAGCCAAGCTTTTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59790	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				GCCAGCCAAGCTTTTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59791	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				GCCAGCCAAGCTTTTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59792	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				GCCCTAACTGAAGAAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59793	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				GCCCTAACTGAAGAAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59794	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				GCCCTAACTGAAGAAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59795	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				GGGGACTTCTTTACAAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59796	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				GGGGACTTCTTTACAAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59797	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				GGGGACTTCTTTACAAGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59798	hg19	N/A	enh110004	N/A	Enhatls117205	enhancer	E_693				TGGAATGATGACCCATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109528	chr22	30192744	30197984	29796755	29801995	59799	hg19	N/A	N/A	N/A	Enhatls117205	enhancer	E_693				TGGAATGATGACCCATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1359
enhrx-109529	chr22	30192744	30197984	29796755	29801995	59800	hg19	N/A	N/A	N/A	Enhatls117206	enhancer	E_693				TGGAATGATGACCCATCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					ASCC2	chr22	29788608	29838304	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1360
enhrx-lit800	chr22	30727808	30730420	30331819	30334431	59801	hg19					enhancer	E_696				GTTTAGGACCTGCAGCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit801	chr22	30727808	30730420	30331819	30334431	59802	hg19					enhancer	E_696				CTGATGTTCACAAGGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit802	chr22	30727808	30730420	30331819	30334431	59803	hg19					enhancer	E_696				AACTGGATTTGCTCTCTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit803	chr22	30727808	30730420	30331819	30334431	59804	hg19					enhancer	E_696				TCCGGTCACAGCCTCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit804	chr22	30727808	30730420	30331819	30334431	59805	hg19					enhancer	E_696				CCAAGTTCTTCTTTCTTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit805	chr22	30727808	30730420	30331819	30334431	59806	hg19					enhancer	E_696				ACCTGGGTCTCATTCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59807	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				ACGCTGGCTGGCAGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59808	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				ACGCTGGCTGGCAGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59809	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				ACGCTGGCTGGCAGAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59810	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				CAGCTTGGCCTGCTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59811	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				CAGCTTGGCCTGCTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59812	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				CAGCTTGGCCTGCTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59813	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				AAATGCCTGGGAGGAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59814	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				AAATGCCTGGGAGGAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59815	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				AAATGCCTGGGAGGAGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59816	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				CGGGGGGGGACAGTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59817	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				CGGGGGGGGACAGTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59818	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				CGGGGGGGGACAGTGCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59819	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GTGCACAGCCTGAGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59820	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GTGCACAGCCTGAGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59821	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GTGCACAGCCTGAGAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59822	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GGATGCCTGAAAGGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59823	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GGATGCCTGAAAGGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59824	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GGATGCCTGAAAGGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59825	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				TGAGAGCTCAAAACAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59826	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				TGAGAGCTCAAAACAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59827	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				TGAGAGCTCAAAACAGAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59828	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GAGAGCAGGCTGTCCGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59829	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GAGAGCAGGCTGTCCGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59830	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GAGAGCAGGCTGTCCGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59831	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GGCAACAAAGATTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59832	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GGCAACAAAGATTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59833	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GGCAACAAAGATTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59834	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GCAGCTGTATGGCCTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59835	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GCAGCTGTATGGCCTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59836	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GCAGCTGTATGGCCTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59837	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				TATGGATGAGGTAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59838	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				TATGGATGAGGTAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59839	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				TATGGATGAGGTAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109591	chr22	30736215	30738128	30340226	30342139	59840	hg19	N/A	N/A	N/A	Enhatls117270	enhancer	E_697				GGAGCGCTATGAAAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1422
enhrx-109592	chr22	30736215	30738128	30340226	30342139	59841	hg19	N/A	N/A	N/A	Enhatls117271	enhancer	E_697				GGAGCGCTATGAAAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1423
enhrx-109593	chr22	30736215	30738128	30340226	30342139	59842	hg19	N/A	N/A	N/A	Enhatls117272	enhancer	E_697				GGAGCGCTATGAAAAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SF3A1	chr22	30331987	30356894	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1424
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59843	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCTCCTAGTCCTCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59844	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				GCTCCTAGTCCTCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59845	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCTCCTAGTCCTCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59846	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCTCCTAGTCCTCACACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59847	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				TCAGTAACCAGAATTCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59848	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				TCAGTAACCAGAATTCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59849	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				TCAGTAACCAGAATTCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59850	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				TCAGTAACCAGAATTCGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59851	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTAAAGGGCCAGCCCACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59852	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				GTAAAGGGCCAGCCCACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59853	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTAAAGGGCCAGCCCACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59854	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTAAAGGGCCAGCCCACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59855	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCCCAGGCTGCCTTACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59856	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				GCCCAGGCTGCCTTACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59857	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCCCAGGCTGCCTTACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59858	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GCCCAGGCTGCCTTACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59859	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CTATGACTCAGAGATGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59860	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				CTATGACTCAGAGATGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59861	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CTATGACTCAGAGATGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59862	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CTATGACTCAGAGATGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59863	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GGCTTTGCCAGGCAGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59864	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				GGCTTTGCCAGGCAGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59865	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GGCTTTGCCAGGCAGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59866	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GGCTTTGCCAGGCAGGATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59867	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTACAGGGAGGTCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59868	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				GTACAGGGAGGTCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59869	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTACAGGGAGGTCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59870	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				GTACAGGGAGGTCCCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59871	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CCTGTCCCCACAACCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59872	hg19	N/A	N/A	fant61049	Enhatls117348	enhancer	E_698				CCTGTCCCCACAACCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59873	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CCTGTCCCCACAACCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					SLC35E4	chr22	30635780	30669016	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-109671	chr22	31042838	31046206	30646851	30650219	59874	hg19	N/A	N/A	N/A	Enhatls117348	enhancer	E_698				CCTGTCCCCACAACCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	NF2	direct	Highly Significant	NA					DUSP18	chr22	30652050	30667885	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1502
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59875	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59876	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59877	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59878	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59879	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59880	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59881	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				TCTGGGTCTGTGTGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59882	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59883	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59884	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59885	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59886	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59887	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59888	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				TGGATATTCTCCTCAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59889	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59890	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59891	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59892	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59893	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59894	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59895	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				GCGTGGGAGGAATCATGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59896	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59897	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59898	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59899	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59900	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59901	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59902	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				GCGCCTTCAGGAAACAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59903	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59904	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59905	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59906	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59907	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59908	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59909	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				GGGGGACTCGCGGAAACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59910	hg19	N/A	enh20168	N/A	Enhatls117745	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5459				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59911	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5181				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59912	hg19	N/A	N/A	fant61158	Enhatls117745	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	5034				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110030	chr22	35768853	35778019	35372860	35382026	59913	hg19	N/A	N/A	N/A	Enhatls117745	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	4304				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1861
enhrx-110031	chr22	35768853	35778019	35372860	35382026	59914	hg19	N/A	N/A	fant61159	N/A	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2980				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1862
enhrx-110032	chr22	35768853	35778019	35372860	35382026	59915	hg19	N/A	N/A	fant61160	N/A	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	2370				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1863
enhrx-110033	chr22	35768853	35778019	35372860	35382026	59916	hg19	N/A	N/A	N/A	Enhatls117746	enhancer	E_699				TCAGCTTCTCTTTAGGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					HMOX1	chr22	35380360	35394212	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1864
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59917	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				TGCTGCTGCCCCGATCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59918	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				TGCTGCTGCCCCGATCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59919	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				TGCTGCTGCCCCGATCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59920	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				TGCTGCTGCCCCGATCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59921	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GGCTGAGGAGAGAGCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59922	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GGCTGAGGAGAGAGCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59923	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GGCTGAGGAGAGAGCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59924	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GGCTGAGGAGAGAGCCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59925	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				CAGTGACACCTAGAGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59926	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				CAGTGACACCTAGAGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59927	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				CAGTGACACCTAGAGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59928	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				CAGTGACACCTAGAGAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59929	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GCTGGTGCTGCCACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59930	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GCTGGTGCTGCCACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59931	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GCTGGTGCTGCCACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59932	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GCTGGTGCTGCCACTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59933	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				TCGCGGCCTGTAGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59934	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				TCGCGGCCTGTAGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59935	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				TCGCGGCCTGTAGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59936	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				TCGCGGCCTGTAGCTGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59937	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GTAGCCCTTTCACCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59938	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GTAGCCCTTTCACCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59939	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GTAGCCCTTTCACCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59940	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GTAGCCCTTTCACCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59941	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				TGTGAGGCAGGGAAAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59942	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				TGTGAGGCAGGGAAAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59943	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				TGTGAGGCAGGGAAAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59944	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				TGTGAGGCAGGGAAAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59945	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GGAACACAGCAGCAGAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59946	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GGAACACAGCAGCAGAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59947	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GGAACACAGCAGCAGAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59948	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GGAACACAGCAGCAGAGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59949	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GGGTGGAGCGGCTCTCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59950	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GGGTGGAGCGGCTCTCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59951	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GGGTGGAGCGGCTCTCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59952	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GGGTGGAGCGGCTCTCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59953	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GCAGACAAGCTTGCTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59954	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GCAGACAAGCTTGCTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59955	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GCAGACAAGCTTGCTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59956	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GCAGACAAGCTTGCTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110048	chr22	35818633	35824852	35422640	35428859	59957	hg19	N/A	N/A	N/A	Enhatls117763	enhancer	E_700				GTGACTAAGGACAAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1879
enhrx-110049	chr22	35818633	35824852	35422640	35428859	59958	hg19	N/A	N/A	N/A	Enhatls117764	enhancer	E_700				GTGACTAAGGACAAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1880
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59959	hg19	N/A	N/A	N/A	Enhatls117765	enhancer	E_700				GTGACTAAGGACAAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35818633	35824852	35422640	35428859	59960	hg19	N/A	enh35073	N/A	Enhatls117765	enhancer	E_700				GTGACTAAGGACAAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	3362				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59961	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				AGCAAGTGCTTCTCTGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59962	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				AGCAAGTGCTTCTCTGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59963	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				AGCAAGTGCTTCTCTGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59964	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				AATTCGGATATGCCTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59965	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				AATTCGGATATGCCTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59966	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				AATTCGGATATGCCTACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59967	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GCCCTAATAAGGGTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59968	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				GCCCTAATAAGGGTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59969	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GCCCTAATAAGGGTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59970	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GGGTCATTAGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59971	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				GGGTCATTAGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59972	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GGGTCATTAGAACAAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59973	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GCTTCCCTTTCATTTACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59974	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				GCTTCCCTTTCATTTACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59975	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GCTTCCCTTTCATTTACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59976	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				CCTGGAAGTGAATGAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59977	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				CCTGGAAGTGAATGAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59978	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				CCTGGAAGTGAATGAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59979	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GTGAGCACTACGGCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59980	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				GTGAGCACTACGGCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59981	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				GTGAGCACTACGGCATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59982	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				TGCGGTGAGTCCAGGACTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59983	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				TGCGGTGAGTCCAGGACTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59984	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				TGCGGTGAGTCCAGGACTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59985	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				TTGGGTGATGAAGATGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	16581				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59986	hg19	N/A	enh20169	fant61162	Enhatls117765	enhancer	E_701				TTGGGTGATGAAGATGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21072				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35840386	35843382	35444393	35447389	59987	hg19	N/A	enh20169	N/A	Enhatls117765	enhancer	E_701				TTGGGTGATGAAGATGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	21167				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59988	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				TGGATGCCAGGCTTAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59989	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				CAGGGTCGGGCTCCGCGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59990	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				GGAGCCTGCAGGCTGAGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59991	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				GAGCTGGCTGTCCAAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59992	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				CATTGTGGCCCAGCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59993	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				GAGTTCGCTGGGCCGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59994	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				AGTGTTCAGGCTCCAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35863680	35864578	35467687	35468585	59995	hg19	N/A	enh35074	N/A	Enhatls117765	enhancer	E_702				GGGGAAATGTACTAGTGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					MCM5	chr22	35400136	35425431	40402				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	59996	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CACATACATGTAATCATACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	59997	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				GATGGACGCATGCAGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	59998	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CTGCGGTCGTTTTCAGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	59999	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CTGACAAACTGGAATTACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60000	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				TGTGGCTCACAGGTTTATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60001	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CAATTCTATGACTTGAAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60002	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CCTATGAGCTAGCAGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60003	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				GTACGTGTGCCTGCAACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60004	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				TCCAGGATTCTGCCAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60005	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				GACCTGAGCAAAAATGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110050	chr22	35901334	35904469	35505287	35508422	60006	hg19	N/A	enh70433	N/A	Enhatls117765	enhancer	E_703				CGTTGGATGAAAGGTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	26863				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1881
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60007	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				ATTGCCATGTGCGAAGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60008	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				AGGAGAGAGTGCACATCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	direct	Highly Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60009	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				GTCAGGCAATTGCACTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	indirect	Non Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60010	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				CTGACCAGAGTGAAAATCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	indirect	Non Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60011	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				CTAGGCCATACAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	indirect	Non Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110054	chr22	35956039	35959200	35559992	35563153	60012	hg19	N/A	enh35075	N/A	Enhatls117768	enhancer	E_704				GGTGGGGTCATGGAAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ISX	indirect	Non Significant	NA					RASD2	chr22	35540830	35553999	2140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1885
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60013	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60014	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60015	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60016	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60017	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60018	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60019	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60020	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60021	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60022	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60023	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60024	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60025	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60026	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60027	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60028	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60029	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				GAGCTGCCACAGTGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60030	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60031	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60032	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60033	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60034	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60035	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60036	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60037	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60038	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60039	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60040	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60041	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60042	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60043	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60044	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60045	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60046	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				CTGGTGATTGGTTAGGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60047	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60048	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60049	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60050	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60051	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60052	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60053	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60054	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60055	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60056	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60057	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60058	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60059	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60060	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60061	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60062	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60063	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				TGTGGTGTGACCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60064	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60065	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60066	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60067	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60068	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60069	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60070	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60071	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60072	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60073	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60074	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60075	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60076	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60077	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60078	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60079	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60080	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				GACCCCACATGCGTCACGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60081	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60082	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60083	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60084	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60085	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60086	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60087	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60088	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60089	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60090	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60091	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60092	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60093	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60094	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60095	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60096	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60097	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				ATGAAGTCATTGTTGGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60098	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60099	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60100	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60101	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60102	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60103	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60104	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60105	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60106	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60107	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60108	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60109	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60110	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60111	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60112	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60113	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60114	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				GCTAGTTCCCCAGCCTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60115	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60116	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60117	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60118	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60119	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60120	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60121	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60122	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60123	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60124	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60125	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60126	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60127	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60128	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60129	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60130	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60131	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				TCTTTCTGAGTCTCTTGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60132	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60133	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60134	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60135	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60136	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60137	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60138	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60139	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60140	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60141	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60142	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60143	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60144	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60145	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60146	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60147	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60148	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				CAAACCGCAGCCACACACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60149	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60150	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60151	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60152	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60153	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60154	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60155	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60156	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60157	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60158	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60159	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60160	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60161	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60162	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60163	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60164	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60165	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				GGCTTCCCTGATGAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60166	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60167	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60168	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60169	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60170	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60171	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60172	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60173	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60174	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60175	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60176	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60177	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60178	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60179	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60180	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60181	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60182	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				TTCTAAGCAACATAAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60183	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60184	hg19	N/A	enh82387	fant61272	Enhatls118008	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60185	hg19	N/A	enh82387	N/A	Enhatls118008	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110271	chr22	37895630	37912139	37499623	37516132	60186	hg19	N/A	N/A	N/A	Enhatls118008	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2102
enhrx-110272	chr22	37895630	37912139	37499623	37516132	60187	hg19	N/A	N/A	N/A	Enhatls118009	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2103
enhrx-110273	chr22	37895630	37912139	37499623	37516132	60188	hg19	N/A	N/A	N/A	Enhatls118010	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2104
enhrx-110274	chr22	37895630	37912139	37499623	37516132	60189	hg19	N/A	N/A	N/A	Enhatls118011	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2105
enhrx-110275	chr22	37895630	37912139	37499623	37516132	60190	hg19	N/A	N/A	N/A	Enhatls118012	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2106
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60191	hg19	N/A	N/A	N/A	Enhatls118013	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60192	hg19	N/A	enh63071	N/A	Enhatls118013	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60193	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60194	hg19	N/A	enh63071	N/A	Enhatls118014	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60195	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60196	hg19	N/A	enh63071	N/A	Enhatls118015	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60197	hg19	N/A	enh63071	N/A	N/A	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60198	hg19	N/A	enh63071	N/A	Enhatls118016	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110276	chr22	37895630	37912139	37499623	37516132	60199	hg19	N/A	N/A	N/A	Enhatls118016	enhancer	E_706				GCCGCCACACACCTGCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					CARD10	chr22	37490361	37519542	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2107
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60200	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				TGCCTGGCACACACTCAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60201	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				TGCCTGGCACACACTCAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60202	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				TGCCTGGCACACACTCAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60203	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				TGCCTGGCACACACTCAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60204	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				ATTGAAGCGAGGCTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60205	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				ATTGAAGCGAGGCTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60206	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				ATTGAAGCGAGGCTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60207	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				ATTGAAGCGAGGCTGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60208	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				GGGACCAGCGCGTCATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60209	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				GGGACCAGCGCGTCATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60210	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				GGGACCAGCGCGTCATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60211	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				GGGACCAGCGCGTCATGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60212	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				CGCTAAAGTGTGCGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60213	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				CGCTAAAGTGTGCGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60214	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				CGCTAAAGTGTGCGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60215	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				CGCTAAAGTGTGCGCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60216	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				AGCGAGATGGTGACGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60217	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				AGCGAGATGGTGACGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60218	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				AGCGAGATGGTGACGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60219	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				AGCGAGATGGTGACGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60220	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				GGGGTTCTCTAGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60221	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				GGGGTTCTCTAGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60222	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				GGGGTTCTCTAGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60223	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				GGGGTTCTCTAGCCACGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60224	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				CCGAGCTTCCGGCTATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60225	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				CCGAGCTTCCGGCTATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60226	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				CCGAGCTTCCGGCTATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60227	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				CCGAGCTTCCGGCTATCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60228	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				CCGGACCGATGGACTGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60229	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				CCGGACCGATGGACTGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60230	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				CCGGACCGATGGACTGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60231	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				CCGGACCGATGGACTGGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110324	chr22	38079863	38085101	37683856	37689094	60232	hg19	N/A	N/A	N/A	Enhatls118065	enhancer	E_710				ACACAGCAGGCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2155
enhrx-110325	chr22	38079863	38085101	37683856	37689094	60233	hg19	N/A	N/A	N/A	Enhatls118066	enhancer	E_710				ACACAGCAGGCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2156
enhrx-110326	chr22	38079863	38085101	37683856	37689094	60234	hg19	N/A	N/A	N/A	Enhatls118067	enhancer	E_710				ACACAGCAGGCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2157
enhrx-110327	chr22	38079863	38085101	37683856	37689094	60235	hg19	N/A	N/A	N/A	Enhatls118068	enhancer	E_710				ACACAGCAGGCGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					NOL12	chr22	37686342	37693474	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2158
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60236	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60237	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60238	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60239	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60240	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60241	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60242	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60243	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60244	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60245	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60246	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60247	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60248	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60249	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60250	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60251	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				GGAGGCTTTGACTCAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60252	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60253	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60254	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60255	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60256	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60257	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60258	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60259	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60260	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60261	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60262	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60263	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60264	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60265	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60266	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60267	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				TCTTTCTAGAGTGGATAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60268	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60269	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60270	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60271	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60272	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60273	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60274	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60275	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60276	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60277	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60278	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60279	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60280	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60281	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60282	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60283	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				TCCAAGGACACATATGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60284	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60285	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60286	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60287	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60288	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60289	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60290	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60291	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60292	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60293	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60294	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60295	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60296	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60297	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60298	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60299	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				GCTCTGTTCTTTCGGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60300	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60301	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60302	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60303	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60304	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60305	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60306	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60307	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60308	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60309	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60310	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60311	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60312	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60313	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60314	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60315	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				AGCAGGCGCATGCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60316	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60317	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60318	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60319	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60320	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60321	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60322	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60323	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60324	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60325	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60326	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60327	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60328	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60329	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60330	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60331	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				GAGAGGGCTTTGAGCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60332	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60333	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60334	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60335	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60336	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60337	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60338	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60339	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60340	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60341	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60342	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60343	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60344	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60345	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60346	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60347	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				CAGCGGGCAGGCAGCGGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60348	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60349	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60350	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60351	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60352	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60353	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60354	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60355	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60356	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60357	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60358	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60359	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60360	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60361	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60362	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60363	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				GGGGTCACTGGCGGGGTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60364	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60365	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60366	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60367	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60368	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60369	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60370	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60371	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60372	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60373	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60374	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60375	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60376	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60377	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60378	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60379	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				ATTAGTCATCCTCTATCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60380	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60381	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60382	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60383	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60384	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60385	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60386	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60387	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60388	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60389	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60390	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60391	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60392	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60393	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60394	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60395	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				GACAGGAGACGGGCCCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60396	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60397	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60398	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60399	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60400	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60401	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60402	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60403	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60404	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60405	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60406	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60407	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60408	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60409	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60410	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60411	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				CTTCCATCTCAGACAGTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60412	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60413	hg19	N/A	enh6852	fant61285	N/A	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60414	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60415	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60416	hg19	N/A	enh6852	fant61286	Enhatls118082	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60417	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60418	hg19	N/A	enh6852	fant61287	Enhatls118082	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60419	hg19	N/A	enh6852	N/A	Enhatls118082	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60420	hg19	N/A	enh6852	N/A	N/A	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60421	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60422	hg19	N/A	enh6852	fant61288	Enhatls118083	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60423	hg19	N/A	enh6852	N/A	Enhatls118083	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110338	chr22	38137690	38153371	37741683	37757364	60424	hg19	N/A	N/A	N/A	Enhatls118083	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2169
enhrx-110339	chr22	38137690	38153371	37741683	37757364	60425	hg19	N/A	N/A	N/A	Enhatls118084	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2170
enhrx-110340	chr22	38137690	38153371	37741683	37757364	60426	hg19	N/A	N/A	N/A	Enhatls118085	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2171
enhrx-110341	chr22	38137690	38153371	37741683	37757364	60427	hg19	N/A	N/A	N/A	Enhatls118086	enhancer	E_711				CCCTGTCCTACTTTACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2172
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60428	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CTAGGGCAGCTACAAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60429	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CTAGGGCAGCTACAAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60430	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CTAGGGCAGCTACAAAAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60431	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CCACTATCAGAATAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60432	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CCACTATCAGAATAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60433	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CCACTATCAGAATAGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60434	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CATTTGCACCAGCAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60435	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CATTTGCACCAGCAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60436	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CATTTGCACCAGCAGCGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60437	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				ATGTAAGGACTCATTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60438	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				ATGTAAGGACTCATTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60439	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				ATGTAAGGACTCATTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60440	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GTAGTAGAATGAATAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60441	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GTAGTAGAATGAATAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60442	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GTAGTAGAATGAATAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60443	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				ACTGCTACACACAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60444	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				ACTGCTACACACAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60445	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				ACTGCTACACACAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60446	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AAGGCTGTACGATTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60447	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AAGGCTGTACGATTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60448	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AAGGCTGTACGATTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60449	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GTGATAGTGGTCAGAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60450	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GTGATAGTGGTCAGAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60451	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GTGATAGTGGTCAGAAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60452	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GGTCTGGGTTGTGGTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60453	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GGTCTGGGTTGTGGTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60454	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GGTCTGGGTTGTGGTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60455	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AAAGTCTCGCTGTGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60456	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AAAGTCTCGCTGTGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60457	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AAAGTCTCGCTGTGTCATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60458	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CAAATCGTAAGTGCAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60459	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CAAATCGTAAGTGCAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60460	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CAAATCGTAAGTGCAAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60461	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GTCTCAATGGTGCAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60462	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GTCTCAATGGTGCAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60463	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GTCTCAATGGTGCAGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60464	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GCCCTGTCACCGCGGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60465	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GCCCTGTCACCGCGGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60466	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GCCCTGTCACCGCGGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60467	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AAGTTCTGGTCAACTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60468	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AAGTTCTGGTCAACTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60469	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AAGTTCTGGTCAACTGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60470	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GTAAGGCTCACCTAGCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60471	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GTAAGGCTCACCTAGCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60472	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GTAAGGCTCACCTAGCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60473	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AACAATAACGTCTACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60474	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AACAATAACGTCTACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60475	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AACAATAACGTCTACCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60476	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AGCGATTCAGAGCTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60477	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AGCGATTCAGAGCTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60478	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AGCGATTCAGAGCTGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60479	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GCACTGGTGTCTGTCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60480	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GCACTGGTGTCTGTCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60481	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GCACTGGTGTCTGTCTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60482	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CTTGAGGGTGACTGACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60483	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CTTGAGGGTGACTGACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60484	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CTTGAGGGTGACTGACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60485	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GAGGTTTCCGGTACACGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60486	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GAGGTTTCCGGTACACGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60487	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GAGGTTTCCGGTACACGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60488	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				CGTCCCACAGTACTTTACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60489	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				CGTCCCACAGTACTTTACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60490	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				CGTCCCACAGTACTTTACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60491	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				TGCTCTCCCCTTGTTATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60492	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				TGCTCTCCCCTTGTTATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60493	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				TGCTCTCCCCTTGTTATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60494	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AGGCTTCGTGACTTTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60495	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AGGCTTCGTGACTTTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60496	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AGGCTTCGTGACTTTTAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60497	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				TGAGTGAAAATGTTTGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60498	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				TGAGTGAAAATGTTTGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60499	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				TGAGTGAAAATGTTTGTTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60500	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				GCACAGTTGTCCCCGGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60501	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				GCACAGTTGTCCCCGGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60502	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				GCACAGTTGTCCCCGGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110348	chr22	38169486	38181584	37773479	37785577	60503	hg19	N/A	N/A	N/A	Enhatls118093	enhancer	E_712				AACCAAGGCACCTGGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2179
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60504	hg19	N/A	enh20200	N/A	N/A	enhancer	E_712				AACCAAGGCACCTGGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110349	chr22	38169486	38181584	37773479	37785577	60505	hg19	N/A	enh20200	N/A	Enhatls118094	enhancer	E_712				AACCAAGGCACCTGGTCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TRIOBP	chr22	37697047	37776556	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2180
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60506	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60507	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60508	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60509	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60510	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60511	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60512	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60513	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60514	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60515	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60516	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CCAGGTGATACAATACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60517	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60518	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60519	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60520	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60521	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60522	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60523	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60524	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60525	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60526	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60527	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CTAACCCCTGCTCTATTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60528	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60529	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60530	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60531	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60532	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60533	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60534	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60535	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60536	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60537	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60538	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGGCTGTCAGACACCGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60539	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60540	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60541	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60542	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60543	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60544	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60545	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60546	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60547	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60548	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60549	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				TGAGCCTTCCTGACACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60550	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60551	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60552	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60553	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60554	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60555	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60556	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60557	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60558	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60559	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60560	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				ATTTCAAGAGCAGTCAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60561	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60562	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60563	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60564	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60565	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60566	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60567	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60568	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60569	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60570	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60571	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GTTGTAGAGACTCTTAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60572	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60573	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60574	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60575	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60576	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60577	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60578	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60579	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60580	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60581	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60582	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				AGCCCTCTCAGTACACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60583	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60584	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60585	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60586	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60587	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60588	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60589	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60590	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60591	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60592	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60593	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				ACTTGTCTGGGGCTCCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60594	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60595	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60596	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60597	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60598	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60599	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60600	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60601	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60602	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60603	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60604	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				TGGAGGATAGTTCAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60605	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60606	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60607	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60608	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60609	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60610	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60611	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60612	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60613	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60614	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60615	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GCAGGATGGTCTATGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60616	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60617	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60618	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60619	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60620	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60621	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60622	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60623	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60624	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60625	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60626	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CGGGGCTCAGGGTACCGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60627	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60628	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60629	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60630	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60631	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60632	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60633	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60634	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60635	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60636	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60637	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CAGTGGAAGGCGCTGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60638	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60639	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60640	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60641	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60642	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60643	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60644	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60645	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60646	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60647	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60648	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CCATTGTCCACTGCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60649	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60650	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60651	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60652	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60653	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60654	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60655	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60656	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60657	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60658	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60659	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CAGTCTGTGCCCCAGGAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60660	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60661	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60662	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60663	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60664	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60665	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60666	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60667	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60668	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60669	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60670	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CTAAGAATCCTAGAATCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60671	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60672	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60673	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60674	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60675	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60676	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60677	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60678	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60679	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60680	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60681	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				TTCTATTGACTCCTGGTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60682	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60683	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60684	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60685	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60686	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60687	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60688	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60689	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60690	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60691	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60692	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				TGCTTTACAAGGTGGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60693	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60694	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60695	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60696	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60697	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60698	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60699	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60700	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60701	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60702	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60703	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGCACAAGATCACATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60704	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60705	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60706	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60707	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60708	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60709	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60710	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60711	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60712	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60713	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60714	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CATCACCCCTGAGCACTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60715	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60716	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60717	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60718	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60719	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60720	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60721	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60722	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60723	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60724	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60725	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				ACTCCAGCTAACTATTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60726	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60727	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60728	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60729	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60730	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60731	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60732	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60733	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60734	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60735	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60736	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				AGGGGCCTCTGCGGAAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60737	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60738	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60739	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60740	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60741	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60742	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60743	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60744	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60745	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60746	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60747	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				ATAGAGAATGAGCCTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60748	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60749	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60750	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60751	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60752	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60753	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60754	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60755	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60756	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60757	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60758	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				AACCACCACCACACTAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60759	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60760	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60761	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60762	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60763	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60764	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60765	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60766	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60767	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60768	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60769	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				AGATCCCTGAGCTTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60770	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60771	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60772	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60773	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60774	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60775	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60776	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60777	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60778	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60779	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60780	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GACACCTGGACCAAAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60781	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60782	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60783	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60784	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60785	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60786	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60787	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60788	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60789	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60790	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60791	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CCTAGCTTGAAACTTTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60792	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60793	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60794	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60795	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60796	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60797	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60798	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60799	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60800	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60801	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60802	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGTGTCCCGCCTCCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60803	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60804	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60805	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60806	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60807	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60808	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60809	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60810	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60811	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60812	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60813	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGGGCTTCGCGGGCACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60814	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60815	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60816	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60817	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60818	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60819	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60820	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60821	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60822	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60823	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60824	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CGCGCCTCCGGCGCGGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60825	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60826	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60827	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60828	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60829	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60830	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60831	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60832	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60833	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60834	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60835	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				AATGAGGCGAGCGGGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60836	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60837	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60838	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60839	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60840	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60841	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60842	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60843	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60844	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60845	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60846	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				TGCTCGGGCAGGTTAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60847	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60848	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60849	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60850	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60851	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60852	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60853	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60854	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60855	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60856	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60857	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGGCGCCGACCGGCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60858	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60859	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60860	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60861	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60862	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60863	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60864	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60865	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60866	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60867	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60868	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				CCGCCGTCCCGGCCAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60869	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60870	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60871	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60872	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60873	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60874	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60875	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60876	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60877	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60878	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60879	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGTAGCCCTCGCACTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60880	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60881	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60882	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60883	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60884	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60885	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60886	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60887	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60888	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60889	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60890	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GCCCGACCTGCTGTGAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60891	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60892	hg19	N/A	enh20202	fant61292	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					EIF3L	chr22	37848867	37889407	6824				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60893	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6822				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60894	hg19	N/A	enh20202	fant61293	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	6641				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60895	hg19	N/A	enh20202	N/A	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	5029				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110373	chr22	38288312	38308546	37892305	37912539	60896	hg19	N/A	N/A	N/A	Enhatls118120	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	4514				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2204
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60897	hg19	N/A	enh20203	N/A	N/A	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60898	hg19	N/A	enh20203	N/A	Enhatls118121	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110374	chr22	38288312	38308546	37892305	37912539	60899	hg19	N/A	N/A	N/A	Enhatls118121	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2205
enhrx-110375	chr22	38288312	38308546	37892305	37912539	60900	hg19	N/A	N/A	N/A	Enhatls118122	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2206
enhrx-110376	chr22	38288312	38308546	37892305	37912539	60901	hg19	N/A	N/A	N/A	Enhatls118123	enhancer	E_713				GGCGGCGCCTGTCACCGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2207
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60902	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60903	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60904	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60905	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60906	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60907	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60908	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60909	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCTGGTCCCAAGAACACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60910	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60911	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60912	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60913	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60914	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60915	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60916	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60917	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CTGCGGTTCACTGCATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60918	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60919	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60920	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60921	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60922	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60923	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60924	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60925	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				ATGCCTGAGCCATAAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60926	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60927	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60928	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60929	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60930	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60931	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60932	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60933	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GCAAGGGCCATCTTGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60934	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60935	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60936	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60937	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60938	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60939	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60940	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60941	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GGGGAACTGTCTACTGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60942	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60943	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60944	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60945	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60946	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60947	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60948	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60949	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GAGTGACTCACACAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60950	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60951	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60952	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60953	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60954	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60955	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60956	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60957	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CAGAGGAGCCGTGCCCGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60958	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60959	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60960	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60961	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60962	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60963	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60964	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60965	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				GACGCACAGCCACCACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60966	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60967	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60968	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60969	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60970	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60971	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60972	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60973	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCGAGTACAGTACACCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60974	hg19	N/A	enh88687	N/A	Enhatls118129	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110382	chr22	38326278	38330518	37930271	37934511	60975	hg19	N/A	N/A	N/A	Enhatls118129	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2213
enhrx-110383	chr22	38326278	38330518	37930271	37934511	60976	hg19	N/A	N/A	N/A	Enhatls118130	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2214
enhrx-110384	chr22	38326278	38330518	37930271	37934511	60977	hg19	N/A	N/A	N/A	Enhatls118131	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2215
enhrx-110385	chr22	38326278	38330518	37930271	37934511	60978	hg19	N/A	N/A	N/A	Enhatls118132	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2216
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60979	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60980	hg19	N/A	N/A	fant61294	Enhatls118133	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110386	chr22	38326278	38330518	37930271	37934511	60981	hg19	N/A	N/A	N/A	Enhatls118133	enhancer	E_714				CCAGTGTCACACAGTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2217
enhrx-110387	chr22	38334969	38340647	37938962	37944640	60982	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				AGTGACACAGGCCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	60983	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				AGTGACACAGGCCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	60984	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				AGTGACACAGGCCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	60985	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				AGTGACACAGGCCTGGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	60986	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				TCTGTGCTGCAGAGTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	60987	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				TCTGTGCTGCAGAGTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	60988	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				TCTGTGCTGCAGAGTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	60989	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				TCTGTGCTGCAGAGTTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	60990	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				ATGAAGATGTTGAAACTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	60991	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				ATGAAGATGTTGAAACTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	60992	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				ATGAAGATGTTGAAACTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	60993	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				ATGAAGATGTTGAAACTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	60994	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				ACAGCACGAGAAGCCAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	60995	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				ACAGCACGAGAAGCCAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	60996	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				ACAGCACGAGAAGCCAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	60997	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				ACAGCACGAGAAGCCAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	60998	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				GGCTGTGCTCTGTTTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	60999	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				GGCTGTGCTCTGTTTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61000	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				GGCTGTGCTCTGTTTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61001	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				GGCTGTGCTCTGTTTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	61002	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				AGAGCAGTCAGAGGTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	61003	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				AGAGCAGTCAGAGGTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61004	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				AGAGCAGTCAGAGGTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61005	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				AGAGCAGTCAGAGGTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	61006	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				GGCTGAATCACCGCTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	61007	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				GGCTGAATCACCGCTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61008	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				GGCTGAATCACCGCTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61009	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				GGCTGAATCACCGCTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	61010	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				GGATGCTGTGACGGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	61011	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				GGATGCTGTGACGGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61012	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				GGATGCTGTGACGGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61013	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				GGATGCTGTGACGGACCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	61014	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				GCAGGCCAGCAAGTGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	61015	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				GCAGGCCAGCAAGTGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61016	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				GCAGGCCAGCAAGTGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61017	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				GCAGGCCAGCAAGTGGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110387	chr22	38334969	38340647	37938962	37944640	61018	hg19	N/A	N/A	N/A	Enhatls118134	enhancer	E_715				CTGTCCTGTGCAGGCGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2218
enhrx-110388	chr22	38334969	38340647	37938962	37944640	61019	hg19	N/A	N/A	N/A	Enhatls118135	enhancer	E_715				CTGTCCTGTGCAGGCGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MICALL1	chr22	37905656	37942822	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2219
enhrx-110389	chr22	38334969	38340647	37938962	37944640	61020	hg19	N/A	N/A	N/A	Enhatls118136	enhancer	E_715				CTGTCCTGTGCAGGCGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2220
enhrx-110390	chr22	38334969	38340647	37938962	37944640	61021	hg19	N/A	N/A	N/A	Enhatls118137	enhancer	E_715				CTGTCCTGTGCAGGCGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					C22orf23	chr22	37943049	37953669	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2221
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61022	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				TGCTTCTGTGAAGCCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61023	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				TTCCAGACTTCTGGGGGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61024	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				GTGTGTCTGGATGGGAGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61025	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				AGGGAGTGTTAACACAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61026	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				TCCCCTCTCCACATAGAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61027	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CAGAGGAAATCACTTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61028	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CAGCGACACTACGACTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61029	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CCTTTGCGGCAACCTTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61030	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CTGAGGAGCCTGGCGTCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61031	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				TGAGGGGGCCGGCGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61032	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CCCAGGCTCGAGGGTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110393	chr22	38348643	38351724	37952636	37955717	61033	hg19	N/A	N/A	fant61295	N/A	enhancer	E_716				CGGGCTCTGTATCATGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2224
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61034	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61035	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61036	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61037	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61038	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61039	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61040	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61041	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61042	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61043	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61044	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61045	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61046	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61047	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61048	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61049	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61050	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61051	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGAGCATGCACCTATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61052	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61053	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61054	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61055	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61056	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61057	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61058	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61059	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61060	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61061	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61062	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61063	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61064	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61065	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61066	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61067	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61068	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61069	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGGGGGATCCAAAGGGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61070	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61071	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61072	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61073	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61074	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61075	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61076	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61077	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61078	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61079	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61080	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61081	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61082	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61083	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61084	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61085	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61086	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61087	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTCTGCTTGGAAGGCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61088	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61089	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61090	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61091	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61092	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61093	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61094	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61095	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61096	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61097	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61098	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61099	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61100	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61101	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61102	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61103	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61104	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61105	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTCCCCACTGGAAAGGAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61106	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61107	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61108	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61109	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61110	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61111	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61112	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61113	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61114	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61115	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61116	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61117	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61118	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61119	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61120	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61121	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61122	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61123	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTCCTTAGGAAACAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61124	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61125	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61126	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61127	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61128	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61129	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61130	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61131	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61132	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61133	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61134	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61135	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61136	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61137	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61138	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61139	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61140	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61141	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGCTGCTGACTTGCCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61142	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61143	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61144	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61145	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61146	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61147	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61148	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61149	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61150	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61151	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61152	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61153	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61154	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61155	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61156	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61157	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61158	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61159	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTGTGGCACACCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61160	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61161	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61162	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61163	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61164	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61165	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61166	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61167	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61168	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61169	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61170	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61171	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61172	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61173	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61174	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61175	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61176	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61177	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GATCACCAGCCCCAAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61178	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61179	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61180	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61181	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61182	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61183	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61184	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61185	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61186	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61187	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61188	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61189	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61190	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61191	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61192	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61193	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61194	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61195	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TTAGAACCTCAGGCAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61196	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61197	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61198	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61199	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61200	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61201	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61202	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61203	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61204	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61205	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61206	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61207	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61208	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61209	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61210	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61211	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61212	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61213	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGGTAAGACCAGTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61214	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61215	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61216	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61217	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61218	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61219	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61220	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61221	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61222	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61223	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61224	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61225	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61226	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61227	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61228	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61229	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61230	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61231	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTTAAGGCTGGCATATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61232	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61233	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61234	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61235	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61236	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61237	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61238	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61239	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61240	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61241	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61242	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61243	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61244	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61245	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61246	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61247	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61248	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61249	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGCCAGGCTGCACCTAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61250	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61251	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61252	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61253	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61254	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61255	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61256	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61257	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61258	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61259	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61260	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61261	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61262	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61263	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61264	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61265	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61266	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61267	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACTTGATTAAAGGATTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61268	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61269	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61270	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61271	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61272	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61273	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61274	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61275	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61276	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61277	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61278	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61279	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61280	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61281	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61282	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61283	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61284	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61285	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GAAAGTGACCCCCGCACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61286	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61287	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61288	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61289	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61290	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61291	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61292	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61293	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61294	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61295	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61296	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61297	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61298	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61299	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61300	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61301	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61302	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61303	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTTGCACTCTATCCCCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61304	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61305	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61306	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61307	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61308	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61309	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61310	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61311	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61312	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61313	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61314	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61315	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61316	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61317	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61318	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61319	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61320	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61321	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCCCAGACAGCTGAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61322	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61323	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61324	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61325	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61326	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61327	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61328	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61329	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61330	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61331	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61332	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61333	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61334	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61335	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61336	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61337	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61338	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61339	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACAGAACCAATAGTGGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61340	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61341	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61342	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61343	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61344	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61345	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61346	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61347	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61348	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61349	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61350	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61351	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61352	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61353	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61354	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61355	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61356	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61357	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTGACCCTTTTTTAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61358	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61359	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61360	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61361	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61362	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61363	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61364	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61365	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61366	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61367	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61368	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61369	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61370	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61371	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61372	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61373	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61374	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61375	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTAAGGGATGCACACAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61376	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61377	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61378	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61379	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61380	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61381	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61382	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61383	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61384	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61385	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61386	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61387	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61388	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61389	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61390	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61391	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61392	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61393	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGAAGTGAGTCATGATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61394	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61395	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61396	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61397	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61398	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61399	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61400	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61401	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61402	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61403	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61404	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61405	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61406	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61407	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61408	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61409	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61410	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61411	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CGACCACCTCCATCAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61412	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61413	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61414	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61415	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61416	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61417	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61418	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61419	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61420	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61421	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61422	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61423	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61424	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61425	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61426	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61427	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61428	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61429	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAACCCAGCCTGGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61430	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61431	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61432	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61433	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61434	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61435	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61436	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61437	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61438	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61439	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61440	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61441	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61442	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61443	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61444	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61445	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61446	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61447	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTTCAGATACCACTGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61448	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61449	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61450	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61451	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61452	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61453	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61454	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61455	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61456	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61457	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61458	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61459	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61460	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61461	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61462	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61463	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61464	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61465	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGAGCTCTCTCGCCAGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61466	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61467	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61468	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61469	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61470	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61471	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61472	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61473	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61474	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61475	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61476	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61477	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61478	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61479	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61480	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61481	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61482	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61483	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCACTAGGGGGACAAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61484	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61485	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61486	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61487	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61488	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61489	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61490	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61491	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61492	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61493	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61494	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61495	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61496	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61497	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61498	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61499	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61500	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61501	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TCAGGCCAGAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61502	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61503	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61504	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61505	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61506	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61507	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61508	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61509	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61510	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61511	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61512	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61513	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61514	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61515	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61516	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61517	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61518	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61519	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCTCCATCCCTCCTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61520	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61521	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61522	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61523	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61524	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61525	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61526	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61527	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61528	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61529	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61530	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61531	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61532	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61533	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61534	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61535	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61536	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61537	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACTGCAGCTAGGTCTGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61538	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61539	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61540	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61541	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61542	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61543	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61544	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61545	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61546	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61547	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61548	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61549	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61550	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61551	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61552	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61553	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61554	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61555	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACCTGGGAGGCCTCACTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61556	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61557	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61558	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61559	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61560	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61561	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61562	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61563	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61564	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61565	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61566	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61567	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61568	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61569	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61570	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61571	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61572	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61573	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGATGTAAGTGTGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61574	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61575	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61576	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61577	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61578	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61579	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61580	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61581	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61582	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61583	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61584	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61585	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61586	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61587	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61588	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61589	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61590	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61591	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CTGAGGTTCTCACCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61592	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61593	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61594	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61595	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61596	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61597	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61598	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61599	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61600	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61601	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61602	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61603	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61604	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61605	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61606	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61607	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61608	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61609	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TTATTCCAGGGGCTGTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61610	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61611	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61612	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61613	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61614	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61615	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61616	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61617	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61618	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61619	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61620	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61621	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61622	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61623	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61624	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61625	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61626	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61627	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGGGTTAAGTCAGGGACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61628	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61629	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61630	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61631	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61632	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61633	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61634	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61635	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61636	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61637	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61638	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61639	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61640	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61641	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61642	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61643	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61644	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61645	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CCTCCGAGAGAAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61646	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61647	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61648	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61649	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61650	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61651	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61652	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61653	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61654	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61655	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61656	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61657	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61658	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61659	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61660	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61661	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61662	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61663	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAGCACTGATCGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61664	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61665	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61666	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61667	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61668	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61669	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61670	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61671	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61672	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61673	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61674	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61675	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61676	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61677	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61678	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61679	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61680	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61681	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGACGGAGATGTCAAAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61682	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61683	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61684	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61685	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61686	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61687	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61688	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61689	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61690	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61691	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61692	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61693	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61694	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61695	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61696	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61697	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61698	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61699	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AGCTTGTCGGCCATCACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61700	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61701	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61702	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61703	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61704	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61705	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61706	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61707	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61708	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61709	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61710	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61711	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61712	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61713	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61714	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61715	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61716	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61717	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CATCCGAATGTCATACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61718	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61719	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61720	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61721	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61722	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61723	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61724	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61725	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61726	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61727	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61728	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61729	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61730	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61731	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61732	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61733	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61734	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61735	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GCTCTCCTGCTCCAGTTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61736	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61737	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61738	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61739	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61740	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61741	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61742	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61743	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61744	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61745	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61746	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61747	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61748	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61749	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61750	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61751	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61752	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61753	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TCGGCTCGGTGGCCAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61754	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61755	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61756	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61757	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61758	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61759	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61760	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61761	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61762	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61763	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61764	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61765	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61766	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61767	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61768	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61769	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61770	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61771	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GGTGCGGAGGATGAGGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61772	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61773	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61774	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61775	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61776	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61777	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61778	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61779	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61780	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61781	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61782	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61783	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61784	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61785	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61786	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61787	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61788	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61789	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ATTTTCAAGAGGAAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61790	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61791	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61792	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61793	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61794	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61795	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61796	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61797	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61798	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61799	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61800	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61801	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61802	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61803	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61804	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61805	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61806	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61807	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				CAGTGGTTGGCTATTGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61808	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61809	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61810	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61811	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61812	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61813	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61814	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61815	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61816	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61817	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61818	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61819	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61820	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61821	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61822	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61823	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61824	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61825	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				ACAGTGTGCCTTCCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61826	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61827	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61828	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61829	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61830	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61831	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61832	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61833	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61834	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61835	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61836	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61837	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61838	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61839	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61840	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61841	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61842	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61843	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				TGCCCGCTAGGCGAATCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61844	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61845	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61846	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61847	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61848	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61849	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61850	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61851	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61852	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61853	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61854	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61855	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61856	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61857	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61858	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61859	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61860	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61861	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				AAATGACGCTGGCACACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61862	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61863	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61864	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61865	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61866	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61867	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61868	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61869	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61870	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61871	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61872	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61873	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61874	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61875	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61876	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61877	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61878	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61879	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GTTGGCCACCTGCGCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110395	chr22	38359078	38398663	37963071	38002656	61880	hg19	N/A	enh86447	N/A	N/A	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2226
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61881	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110396	chr22	38359078	38398663	37963071	38002656	61882	hg19	N/A	N/A	N/A	Enhatls118142	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2227
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61883	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110397	chr22	38359078	38398663	37963071	38002656	61884	hg19	N/A	N/A	N/A	Enhatls118143	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2228
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61885	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110398	chr22	38359078	38398663	37963071	38002656	61886	hg19	N/A	N/A	N/A	Enhatls118144	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2229
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61887	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110399	chr22	38359078	38398663	37963071	38002656	61888	hg19	hs517	N/A	N/A	N/A	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2230
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61889	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110400	chr22	38359078	38398663	37963071	38002656	61890	hg19	hs564	N/A	N/A	N/A	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					SOX10	chr22	37970685	37987422	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2231
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61891	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61892	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61893	hg19	hs496	enh59139	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61894	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61895	hg19	hs486	enh59139	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61896	hg19	N/A	enh59139	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38359078	38398663	37963071	38002656	61897	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_717				GACCTTCTTATTGTACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61898	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61899	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61900	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61901	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61902	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61903	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61904	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61905	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61906	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61907	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61908	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61909	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61910	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TAGAGAGTAGGGAAGACCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61911	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61912	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61913	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61914	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61915	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61916	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61917	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61918	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61919	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61920	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61921	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61922	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61923	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGTGTCAGGCCCACTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61924	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61925	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61926	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61927	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61928	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61929	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61930	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61931	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61932	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61933	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61934	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61935	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61936	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CTGAGTCCCTGGCCAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61937	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61938	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61939	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61940	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61941	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61942	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61943	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61944	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61945	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61946	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61947	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61948	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61949	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GTCTACATGATGATGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61950	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61951	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61952	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61953	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61954	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61955	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61956	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61957	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61958	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61959	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61960	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61961	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61962	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CATTACTCTGGACAAAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61963	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61964	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61965	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61966	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61967	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61968	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61969	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61970	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61971	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61972	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61973	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61974	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61975	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TGTGTCCGAAGGGTTAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61976	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61977	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61978	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61979	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61980	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61981	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61982	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61983	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61984	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61985	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61986	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61987	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	61988	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TCTGACCTTTCATAAATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61989	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61990	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61991	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61992	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61993	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61994	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61995	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61996	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61997	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61998	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	61999	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62000	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62001	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GGGATTTGTTGCACTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62002	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62003	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62004	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62005	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62006	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62007	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62008	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62009	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62010	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62011	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62012	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62013	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62014	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GAGCCCTGCTCATAAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62015	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62016	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62017	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62018	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62019	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62020	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62021	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62022	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62023	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62024	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62025	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62026	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62027	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGTGCTGGCACGCACCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62028	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62029	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62030	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62031	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62032	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62033	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62034	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62035	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62036	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62037	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62038	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62039	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62040	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				ACAGTAGAAACAAAAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62041	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62042	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62043	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62044	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62045	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62046	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62047	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62048	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62049	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62050	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62051	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62052	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62053	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GTGGATTGATGTCTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62054	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62055	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62056	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62057	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62058	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62059	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62060	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62061	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62062	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62063	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62064	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62065	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62066	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GTGCCGGGGGGCAGCGCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62067	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62068	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62069	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62070	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62071	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62072	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62073	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62074	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62075	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62076	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62077	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62078	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62079	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TGTGGGGCCGTGCCTGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62080	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62081	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62082	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62083	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62084	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62085	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62086	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62087	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62088	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62089	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62090	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62091	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62092	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AAAGGCTCCTCTGGGGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62093	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62094	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62095	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62096	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62097	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62098	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62099	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62100	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62101	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62102	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62103	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62104	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62105	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GAGCCCTTGGCAGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62106	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62107	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62108	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62109	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62110	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62111	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62112	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62113	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62114	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62115	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62116	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62117	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62118	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GTGTCTCCCTCTTCAGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62119	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62120	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62121	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62122	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62123	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62124	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62125	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62126	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62127	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62128	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62129	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62130	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62131	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CTGTATCTAGGGCTATGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62132	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62133	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62134	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62135	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62136	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62137	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62138	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62139	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62140	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62141	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62142	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62143	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62144	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCAGTCCCGTCAGCATCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62145	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62146	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62147	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62148	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62149	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62150	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62151	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62152	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62153	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62154	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62155	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62156	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62157	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CATGGAGCTCACTCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62158	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62159	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62160	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62161	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62162	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62163	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62164	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62165	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62166	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62167	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62168	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62169	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62170	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AACCAAAGGGTAGAAGCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62171	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62172	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62173	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62174	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62175	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62176	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62177	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62178	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62179	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62180	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62181	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62182	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62183	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GTGGGTAGGAGAAGTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62184	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62185	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62186	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62187	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62188	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62189	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62190	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62191	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62192	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62193	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62194	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62195	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62196	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AATTACTACCTGGGCTAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62197	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62198	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62199	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62200	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62201	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62202	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62203	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62204	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62205	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62206	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62207	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62208	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62209	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AACAGTGAGCCCCTAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62210	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62211	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62212	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62213	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62214	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62215	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62216	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62217	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62218	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62219	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62220	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62221	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62222	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GGGACCTGGACAGCGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62223	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62224	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62225	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62226	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62227	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62228	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62229	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62230	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62231	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62232	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62233	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62234	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62235	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCAACCTTCGGAGGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62236	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62237	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62238	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62239	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62240	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62241	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62242	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62243	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62244	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62245	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62246	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62247	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62248	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CCGTTGATGGGGCAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62249	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62250	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62251	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62252	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62253	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62254	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62255	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62256	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62257	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62258	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62259	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62260	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62261	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				ACTAGCCATAGGGGATGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62262	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62263	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62264	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62265	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62266	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62267	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62268	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62269	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62270	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62271	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62272	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62273	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62274	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CAGACTTCAGACCAAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62275	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62276	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62277	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62278	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62279	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62280	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62281	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62282	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62283	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62284	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62285	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62286	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62287	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				ACTGGGCTCTCACTGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62288	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62289	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62290	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62291	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62292	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62293	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62294	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62295	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62296	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62297	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62298	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62299	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62300	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TGACCCCACTCCTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62301	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62302	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62303	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62304	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62305	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62306	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62307	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62308	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62309	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62310	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62311	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62312	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62313	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CTTCCTGGCCACGTGGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62314	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62315	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62316	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62317	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62318	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62319	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62320	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62321	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62322	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62323	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62324	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62325	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62326	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CTTCCTCCTCCAAGAAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62327	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62328	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62329	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62330	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62331	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62332	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62333	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62334	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62335	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62336	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62337	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62338	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62339	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GATTTCAACTCCAAGTGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62340	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62341	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62342	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62343	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62344	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62345	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62346	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62347	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62348	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62349	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62350	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62351	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62352	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GACAGAATGAACTAATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62353	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62354	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62355	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62356	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62357	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62358	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62359	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62360	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62361	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62362	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62363	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62364	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62365	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GACACAGAGCGCACTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62366	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62367	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62368	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62369	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62370	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62371	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62372	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62373	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62374	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62375	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62376	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62377	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62378	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGTTGGGAGCTTTCGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62379	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62380	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62381	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62382	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62383	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62384	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62385	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62386	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62387	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62388	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62389	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62390	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62391	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCACTCCATGAACAAAGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62392	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62393	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62394	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62395	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62396	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62397	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62398	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62399	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62400	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62401	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62402	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62403	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62404	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGGTTGGCCGGAGGTAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62405	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62406	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62407	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62408	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62409	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62410	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62411	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62412	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62413	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62414	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62415	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62416	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62417	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCCTGAGAGCCAGTGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62418	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62419	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62420	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62421	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62422	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62423	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62424	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62425	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62426	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62427	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62428	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62429	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62430	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGCTCCCTGTCAGTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62431	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62432	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62433	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62434	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62435	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62436	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62437	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62438	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62439	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62440	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62441	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62442	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62443	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				TGGCCCACCCTAACCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62444	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62445	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62446	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62447	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62448	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62449	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62450	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62451	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62452	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62453	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62454	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62455	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62456	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCTTGGAGCAAGCAGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62457	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62458	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62459	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62460	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62461	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62462	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62463	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62464	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62465	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62466	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62467	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62468	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62469	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				AGGGCGGCTGGGGTTTGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62470	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62471	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62472	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62473	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62474	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62475	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62476	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62477	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62478	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62479	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62480	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62481	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62482	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCGAGGGCACACTCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62483	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62484	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62485	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62486	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62487	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62488	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62489	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62490	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62491	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62492	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62493	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62494	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62495	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CAAGGGGCTCAAGGCCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62496	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62497	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62498	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62499	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62500	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62501	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62502	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62503	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62504	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62505	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62506	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62507	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62508	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCCTCACTTGGAAAACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62509	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62510	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62511	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62512	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62513	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62514	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62515	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62516	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62517	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62518	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62519	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62520	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62521	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCCGGGAAGAGCCAGCGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62522	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62523	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62524	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62525	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62526	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62527	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62528	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62529	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62530	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62531	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62532	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62533	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62534	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				ACGGTCAGCGCGCAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62535	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62536	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62537	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62538	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62539	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62540	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62541	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62542	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62543	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62544	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62545	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62546	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62547	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				CTTGCGAGCGGCCCTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62548	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62549	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62550	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62551	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62552	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62553	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62554	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62555	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62556	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62557	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62558	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62559	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62560	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCAGTCGTAGGGGGCGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62561	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62562	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62563	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62564	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62565	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62566	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62567	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62568	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62569	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62570	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62571	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62572	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62573	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				ACCTTGCGCCCCCCAGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62574	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62575	hg19	N/A	enh35081	fant61296	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62576	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62577	hg19	N/A	enh35081	fant61297	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62578	hg19	N/A	enh35081	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62579	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62580	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62581	hg19	hs491	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62582	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62583	hg19	N/A	enh6853	fant61298	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62584	hg19	N/A	enh6853	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110401	chr22	38407591	38440260	38011584	38044253	62585	hg19	N/A	N/A	N/A	Enhatls118145	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2232
enhrx-110402	chr22	38407591	38440260	38011584	38044253	62586	hg19	N/A	N/A	N/A	Enhatls118146	enhancer	E_718				GCCAGGCCTCGTCCCTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					POLR2F	chr22	37953696	38041106	808				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2233
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62587	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62588	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62589	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62590	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62591	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62592	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				AGGGGGTTAGTTGTGCCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62593	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62594	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62595	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62596	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62597	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62598	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				TCTAAAGCCAGTACCAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62599	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62600	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62601	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62602	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62603	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62604	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				CCATGTTGCTCAGCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62605	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62606	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62607	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62608	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62609	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62610	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				TACTGCTTCCTATAGCATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62611	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62612	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62613	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62614	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62615	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62616	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				TGCTTTCTACTCGGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62617	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62618	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62619	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62620	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62621	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62622	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				TAATGAGGCTTGTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110437	chr22	38528614	38534799	38132607	38138792	62623	hg19	N/A	N/A	N/A	Enhatls118180	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2268
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62624	hg19	N/A	N/A	N/A	Enhatls118181	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62625	hg19	N/A	enh90152	N/A	Enhatls118181	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62626	hg19	N/A	enh90152	N/A	N/A	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62627	hg19	N/A	enh90152	N/A	Enhatls118182	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110438	chr22	38528614	38534799	38132607	38138792	62628	hg19	N/A	N/A	N/A	Enhatls118182	enhancer	E_719				GTGCTCCATCATTGTATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2269
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62629	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				AGGACGGGCCCACAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62630	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				AGGACGGGCCCACAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62631	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				AGGACGGGCCCACAGGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62632	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				TTGAGGGAGAAAGTCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62633	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				TTGAGGGAGAAAGTCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62634	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				TTGAGGGAGAAAGTCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62635	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				CTGGTGGGGGGTACACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62636	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				CTGGTGGGGGGTACACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62637	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				CTGGTGGGGGGTACACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62638	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				AGGAGGACGAGATGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62639	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				AGGAGGACGAGATGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62640	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				AGGAGGACGAGATGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62641	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				TGGCCATTGTTATCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62642	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				TGGCCATTGTTATCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62643	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				TGGCCATTGTTATCACTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62644	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				CTAGGCTCCAGGGTCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62645	hg19	N/A	enh6854	fant61304	Enhatls118186	enhancer	E_720				CTAGGCTCCAGGGTCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110439	chr22	38567837	38569501	38171830	38173494	62646	hg19	N/A	enh6854	N/A	Enhatls118186	enhancer	E_720				CTAGGCTCCAGGGTCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					PLA2G6	chr22	38111494	38214778	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2270
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62647	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				ATTTACAGTGGCACAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62648	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				ATTTACAGTGGCACAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62649	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				ATTTACAGTGGCACAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62650	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				ATTTACAGTGGCACAGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62651	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				GTATGGGGCCCGCGGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62652	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				GTATGGGGCCCGCGGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62653	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				GTATGGGGCCCGCGGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62654	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				GTATGGGGCCCGCGGGGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62655	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				ACCGAGCCCCAACCTGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62656	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				ACCGAGCCCCAACCTGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62657	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				ACCGAGCCCCAACCTGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62658	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				ACCGAGCCCCAACCTGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62659	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				GGCTATTTACCCGCCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62660	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				GGCTATTTACCCGCCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62661	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				GGCTATTTACCCGCCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62662	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				GGCTATTTACCCGCCTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62663	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				CATGCGGTACCAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62664	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				CATGCGGTACCAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62665	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				CATGCGGTACCAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62666	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				CATGCGGTACCAGAGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62667	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				GAGGACAGTCCCAGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62668	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				GAGGACAGTCCCAGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62669	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				GAGGACAGTCCCAGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62670	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				GAGGACAGTCCCAGAGACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62671	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				TTTGGTCAACCAGGTCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62672	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				TTTGGTCAACCAGGTCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62673	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				TTTGGTCAACCAGGTCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62674	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				TTTGGTCAACCAGGTCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62675	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				AGCCAGTTCCCAACCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62676	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				AGCCAGTTCCCAACCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62677	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				AGCCAGTTCCCAACCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62678	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				AGCCAGTTCCCAACCCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62679	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				GATGGGGGTTCGGATTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62680	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				GATGGGGGTTCGGATTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62681	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				GATGGGGGTTCGGATTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62682	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				GATGGGGGTTCGGATTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62683	hg19	N/A	enh20204	N/A	Enhatls118190	enhancer	E_721				CTGCCCCCTGCTCTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					MAFF	chr22	38201931	38216507	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62684	hg19	N/A	enh20204	fant61308	Enhatls118190	enhancer	E_721				CTGCCCCCTGCTCTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	516				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62685	hg19	N/A	N/A	fant61308	Enhatls118190	enhancer	E_721				CTGCCCCCTGCTCTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	431				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110440	chr22	38613570	38617422	38217563	38221415	62686	hg19	N/A	N/A	N/A	Enhatls118190	enhancer	E_721				CTGCCCCCTGCTCTGGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	5				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2271
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62687	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACAGGCCTTTGACTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62688	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				GACAGGCCTTTGACTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62689	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACAGGCCTTTGACTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62690	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				TCTCTCGCCCTGGTAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62691	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				TCTCTCGCCCTGGTAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62692	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				TCTCTCGCCCTGGTAAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62693	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				TGTTCTGTTCTTGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62694	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				TGTTCTGTTCTTGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62695	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				TGTTCTGTTCTTGTTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62696	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACAATATAATCATCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62697	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				GACAATATAATCATCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62698	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACAATATAATCATCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62699	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GAGAGCCATTGTTTACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62700	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				GAGAGCCATTGTTTACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62701	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GAGAGCCATTGTTTACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62702	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				ATCTCACCACTGGACCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62703	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				ATCTCACCACTGGACCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62704	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				ATCTCACCACTGGACCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62705	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACTTGGCATGTTCAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62706	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				GACTTGGCATGTTCAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62707	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GACTTGGCATGTTCAGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62708	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GTCACGATGGCCCTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62709	hg19	N/A	enh110011	fant61309	Enhatls118193	enhancer	E_722				GTCACGATGGCCCTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110442	chr22	38623191	38625660	38227184	38229654	62710	hg19	N/A	enh110011	N/A	Enhatls118193	enhancer	E_722				GTCACGATGGCCCTGGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	direct	Highly Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2273
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62711	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				AGCAGGTCACACACACATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62712	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				AGGGAAATACAATCCTAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62713	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				TGAGAAAGAGAGTGCATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62714	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				AGAGCAAACCATGAACAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62715	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				AGAAGCGGTTTCCAGGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62716	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				GCACCAGGAGAAGCGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62717	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				TTTAGGAATAAACTAGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-110444	chr22	38636305	38637701	38240299	38241695	62718	hg19	N/A	enh20205	N/A	Enhatls118195	enhancer	E_723				AAAAGAAGGCAAGTAGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDXP	indirect	Non Significant	NA					TMEM184B	chr22	38219290	38273010	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2275
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62719	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				ACATGGGTATTTGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62720	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				ACATGGGTATTTGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62721	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				ACATGGGTATTTGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62722	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				TCTTCCTTAAAGATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62723	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				TCTTCCTTAAAGATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62724	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				TCTTCCTTAAAGATGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	indirect	Non Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62725	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				TTTCAAAAAAACTAAACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62726	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				TTTCAAAAAAACTAAACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62727	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				TTTCAAAAAAACTAAACGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62728	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				AGTAGGCTGACAGCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62729	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				AGTAGGCTGACAGCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62730	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				AGTAGGCTGACAGCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62731	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				ACAATTTCCTAAGAAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62732	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				ACAATTTCCTAAGAAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62733	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				ACAATTTCCTAAGAAGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62734	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				GCAACTTAGTAATTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62735	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				GCAACTTAGTAATTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62736	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				GCAACTTAGTAATTAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62737	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				TACTGCCCAACAGTGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62738	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				TACTGCCCAACAGTGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62739	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				TACTGCCCAACAGTGAATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62740	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				TGAGGACTCTGCTTCGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62741	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				TGAGGACTCTGCTTCGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62742	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				TGAGGACTCTGCTTCGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112309	chr3	10017629	10021579	9975945	9979895	62743	hg19	N/A	N/A	N/A	Enhatls120173	enhancer	E_724				GTGAAACACTAGAAGAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	438
enhrx-112310	chr3	10017629	10021579	9975945	9979895	62744	hg19	N/A	N/A	N/A	Enhatls120174	enhancer	E_724				GTGAAACACTAGAAGAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	439
enhrx-112311	chr3	10017629	10021579	9975945	9979895	62745	hg19	N/A	N/A	N/A	Enhatls120175	enhancer	E_724				GTGAAACACTAGAAGAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	440
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62746	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				ACAGGACGCCTTTCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62747	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				ACAGGACGCCTTTCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62748	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				AACAGATGAAAAGGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62749	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				AACAGATGAAAAGGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62750	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				ATTCTCCCACTAGGATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62751	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				ATTCTCCCACTAGGATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62752	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				CTCCATTAGCCTCGAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62753	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				CTCCATTAGCCTCGAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62754	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				GAATCTTGAGCAACTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62755	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				GAATCTTGAGCAACTGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62756	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				TCAGTAACAGAGTTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62757	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				TCAGTAACAGAGTTGGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62758	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				GCCCCGCCACAGCTTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62759	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				GCCCCGCCACAGCTTCGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62760	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				CATCAGGCCTCCCTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62761	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				CATCAGGCCTCCCTGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112315	chr3	10056272	10060683	10014588	10018999	62762	hg19	N/A	N/A	N/A	Enhatls120180	enhancer	E_725				CAGCTTCACCCACAGGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					EMC3	chr3	9962681	10011183	4914				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	444
enhrx-112316	chr3	10056272	10060683	10014588	10018999	62763	hg19	N/A	N/A	N/A	Enhatls120181	enhancer	E_725				CAGCTTCACCCACAGGTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					FANCD2	chr3	10026413	10101932	5118				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	445
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62764	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				GTAGGTCCATTAAGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62765	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				GTAGGTCCATTAAGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62766	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				GTAGGTCCATTAAGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62767	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				GGCCAATCTGGACCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62768	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				GGCCAATCTGGACCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62769	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				GGCCAATCTGGACCCAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62770	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				CTCACACTGTGAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62771	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				CTCACACTGTGAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62772	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				CTCACACTGTGAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62773	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				GCTGTCCTGAATCTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62774	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				GCTGTCCTGAATCTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62775	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				GCTGTCCTGAATCTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62776	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				TGTGGTCTGTGGTGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62777	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				TGTGGTCTGTGGTGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62778	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				TGTGGTCTGTGGTGCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62779	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				GCTGAATCTGCACCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62780	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				GCTGAATCTGCACCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62781	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				GCTGAATCTGCACCTGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62782	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				CACTTCACAAGGATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62783	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				CACTTCACAAGGATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62784	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				CACTTCACAAGGATCAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62785	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				TACTTTTATCAGATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62786	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				TACTTTTATCAGATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62787	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				TACTTTTATCAGATTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62788	hg19	N/A	enh35178	N/A	Enhatls120258	enhancer	E_726				AAAGGACACACCCAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112390	chr3	10396107	10401721	10354423	10360037	62789	hg19	N/A	N/A	N/A	Enhatls120258	enhancer	E_726				AAAGGACACACCCAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	519
enhrx-112391	chr3	10396107	10401721	10354423	10360037	62790	hg19	N/A	N/A	N/A	Enhatls120259	enhancer	E_726				AAAGGACACACCCAATAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	520
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62791	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				AAATGGTGCACTGTTCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62792	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				ACTGTGCTCCTACCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62793	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CTCAGGGCAGAGCTAGTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62794	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GCACTTCTGGGGACACACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62795	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GACTCTGTCCAGCCAGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62796	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				AATTAAATATGCAGCTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62797	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CTGCTTACAGGCATTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62798	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				TGCTCTGGTTCCTAATCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62799	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CCTGCCTGCAACTGTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62800	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				TGACCGCCATGTGTTTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62801	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GGCAAGACTAAGAAGTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62802	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CTCCGAGAATGTCCAGGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62803	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GTAGGCTCACAGACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62804	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				TCAAGAATCTCTGAGGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62805	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				AGCGTGAGCCAGGACACTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62806	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GTCCTGGGCCCATAATAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62807	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				AGTGGAGGAATAACACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62808	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				TGTGAGAGTCTCCCCTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62809	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CAGAGAATGCTAGGTTGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62810	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				CTTAATGAGGAGGTGCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112403	chr3	10641026	10644545	10599341	10602860	62811	hg19	N/A	enh6996	N/A	Enhatls120273	enhancer	E_728				GAGCTGCTGTGTGTACATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA3	direct	Highly Significant	NA					ATP2B2	chr3	10324022	10708007	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	532
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62812	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62813	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62814	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62815	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62816	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62817	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62818	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TACACTTGCATCATGTTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62819	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62820	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62821	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62822	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62823	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62824	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62825	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CAAAGAGGAACGCCTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62826	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62827	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62828	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62829	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62830	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62831	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62832	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GGCACAGATCAGAACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62833	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62834	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62835	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62836	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62837	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62838	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62839	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GCTCTCTGCGAAGACTCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62840	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62841	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62842	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62843	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62844	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62845	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62846	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				AAGGCCTCCTTATCCGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62847	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62848	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62849	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62850	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62851	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62852	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62853	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				ACAAGAAACCCACACAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62854	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62855	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62856	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62857	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62858	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62859	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62860	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GGAATCTGCAGATCCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62861	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62862	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62863	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62864	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62865	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62866	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62867	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				ATTAGGGAGGATCGTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62868	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62869	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62870	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62871	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62872	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62873	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62874	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TGCAATATTGTTGTTACATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62875	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62876	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62877	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62878	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62879	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62880	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62881	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CATTTTAGCACACACAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62882	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62883	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62884	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62885	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62886	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62887	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62888	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				TCTCAAACCACACACTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62889	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62890	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62891	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62892	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62893	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62894	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62895	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				CTATTAGCATAAATATCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112452	chr3	11621814	11636155	11580340	11594681	62896	hg19	N/A	N/A	N/A	Enhatls120330	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	581
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62897	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62898	hg19	N/A	enh7002	fant11172	N/A	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62899	hg19	N/A	enh7002	N/A	N/A	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62900	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62901	hg19	N/A	enh7002	fant11173	Enhatls120331	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112453	chr3	11621814	11636155	11580340	11594681	62902	hg19	N/A	enh7002	N/A	Enhatls120331	enhancer	E_729				GAGAGTTCTGTAACTTGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAF1	direct	Highly Significant	NA					VGLL4	chr3	11556068	11771350	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	582
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62903	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62904	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62905	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62906	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62907	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62908	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GAACTGAACTCAGCTACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62909	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62910	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62911	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62912	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62913	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62914	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GATATTGACAAAGCTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62915	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62916	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62917	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62918	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62919	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62920	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GAGCTTTCAACACCAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62921	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62922	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62923	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62924	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62925	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62926	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				AGGGAGGTCAAGTCTAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62927	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62928	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62929	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62930	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62931	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62932	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GCAGCGGGCTAGACACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62933	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62934	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62935	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62936	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62937	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62938	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GGGCCTGGTCTGCTAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62939	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62940	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62941	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62942	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62943	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62944	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				TGATGAGTCATAGGCACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62945	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62946	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62947	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62948	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62949	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62950	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				ACTTAGTCACTGCCATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62951	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62952	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62953	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62954	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62955	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62956	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				TGTGTAGGTGGGATCTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62957	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112474	chr3	12196761	12199677	12155261	12158177	62958	hg19	N/A	N/A	N/A	Enhatls120354	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	603
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62959	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112475	chr3	12196761	12199677	12155261	12158177	62960	hg19	N/A	N/A	N/A	Enhatls120355	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	604
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62961	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112476	chr3	12196761	12199677	12155261	12158177	62962	hg19	N/A	N/A	N/A	Enhatls120356	enhancer	E_733				GTTCAGAGAACGGAACTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TIMP4	chr3	12153067	12158912	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	605
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62963	hg19	N/A	enh20332	N/A	N/A	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62964	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62965	hg19	N/A	enh20332	fant11189	Enhatls120363	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	1420				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62966	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	1866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62967	hg19	N/A	enh20332	fant11190	Enhatls120363	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	2251				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62968	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				GCAACAGCATATGCTGCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	2481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62969	hg19	N/A	enh20332	N/A	N/A	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62970	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62971	hg19	N/A	enh20332	fant11189	Enhatls120363	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	1420				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62972	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	1866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62973	hg19	N/A	enh20332	fant11190	Enhatls120363	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	2251				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62974	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				CAGAGAAGACCGCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					SYN2	chr3	12004387	12192032	2481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62975	hg19	N/A	enh20332	N/A	N/A	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62976	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62977	hg19	N/A	enh20332	fant11189	Enhatls120363	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	1420				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62978	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	1866				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62979	hg19	N/A	enh20332	fant11190	Enhatls120363	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	2251				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112483	chr3	12232330	12239926	12190830	12198426	62980	hg19	N/A	enh20332	N/A	Enhatls120363	enhancer	E_734				AGTTGCATCTAGTTGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					SYN2	chr3	12004387	12192032	2481				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	612
enhrx-112484	chr3	12347990	12349926	12306491	12308427	62981	hg19	N/A	enh35192	N/A	Enhatls120364	enhancer	E_735				AGAACAATTCAACACCTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	613
enhrx-112484	chr3	12347990	12349926	12306491	12308427	62982	hg19	N/A	enh35192	N/A	Enhatls120364	enhancer	E_735				TTGTGTTTAGAGATAGATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	613
enhrx-112484	chr3	12347990	12349926	12306491	12308427	62983	hg19	N/A	enh35192	N/A	Enhatls120364	enhancer	E_735				GTTATGAGTCACAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	613
enhrx-112484	chr3	12347990	12349926	12306491	12308427	62984	hg19	N/A	enh35192	N/A	Enhatls120364	enhancer	E_735				TCATAAGGTAGGATAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	613
enhrx-112484	chr3	12347990	12349926	12306491	12308427	62985	hg19	N/A	enh35192	N/A	Enhatls120364	enhancer	E_735				AGGCGGGTTAGAGATCAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	613
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62986	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AGCTGAAAAAATACTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62987	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				AGCTGAAAAAATACTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62988	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AGCTGAAAAAATACTTTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62989	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TCACTGACTGTACTTGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62990	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				TCACTGACTGTACTTGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62991	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TCACTGACTGTACTTGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62992	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TGTTAGTTTAAATGTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62993	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				TGTTAGTTTAAATGTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62994	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TGTTAGTTTAAATGTTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62995	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AGGGAGGGGGAATCATTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62996	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				AGGGAGGGGGAATCATTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62997	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AGGGAGGGGGAATCATTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62998	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				GCTTCCTGACCTTACTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	62999	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				GCTTCCTGACCTTACTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63000	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				GCTTCCTGACCTTACTGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63001	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				ATCACTCATTAATCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63002	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				ATCACTCATTAATCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63003	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				ATCACTCATTAATCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63004	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				GCAGTACATGGAAGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63005	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				GCAGTACATGGAAGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63006	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				GCAGTACATGGAAGAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63007	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TGTTACTTGGGAATTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63008	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				TGTTACTTGGGAATTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63009	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				TGTTACTTGGGAATTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63010	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AACTTGCCCAGAGTTGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63011	hg19	N/A	enh82428	N/A	Enhatls120365	enhancer	E_736				AACTTGCCCAGAGTTGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112485	chr3	12377422	12386536	12335923	12345037	63012	hg19	N/A	N/A	N/A	Enhatls120365	enhancer	E_736				AACTTGCCCAGAGTTGCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	614
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63013	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TAAACATCAGACTAACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63014	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				CTTCACATTGGTCAAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63015	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TGCGCATACTGAAAACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63016	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				GCTGTGAGTGCATGGCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63017	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				GAACTGGTAGGGAACCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63018	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				GACCAGAGCACTGTAAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63019	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TTTATCGTACCAAAACATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63020	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				GCTCAGCAATTTCGGGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63021	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TTATACTTTCTCTAGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63022	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TAGGGTTACAGCTCTTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63023	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TGAGAAACTATGTTTCTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63024	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				ATTGGGTAGAAAAAGTACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63025	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				CAATCGGTGGAATTAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63026	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				CATTTTGAGCTTTCCTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63027	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				TAGTTGATGCAATGATCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12435146	12437498	12393647	12395999	63028	hg19	N/A	enh20340	N/A	Enhatls120369	enhancer	E_737				AATCTTGATAAAAAGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63029	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				CCTGACCTTAGGTCAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63030	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				CCTGACCTTAGGTCAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63031	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				CCTGACCTTAGGTCAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63032	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				CCTGACCTTAGGTCAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63033	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				CTTGAGGGATGAGTAGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63034	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				CTTGAGGGATGAGTAGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63035	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				CTTGAGGGATGAGTAGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63036	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				CTTGAGGGATGAGTAGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63037	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				AATTCGAGTTTAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63038	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				AATTCGAGTTTAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63039	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				AATTCGAGTTTAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63040	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				AATTCGAGTTTAGCAAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63041	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				AACGGTTTAATTTTTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63042	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				AACGGTTTAATTTTTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63043	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				AACGGTTTAATTTTTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63044	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				AACGGTTTAATTTTTACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63045	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				CTTCTACTGTGTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63046	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				CTTCTACTGTGTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63047	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				CTTCTACTGTGTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63048	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				CTTCTACTGTGTGGGAACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63049	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				CGAGAAGGAGAAGCTGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63050	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				CGAGAAGGAGAAGCTGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63051	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				CGAGAAGGAGAAGCTGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63052	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				CGAGAAGGAGAAGCTGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63053	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				AATGTTTTGCCAGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63054	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				AATGTTTTGCCAGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63055	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				AATGTTTTGCCAGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63056	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				AATGTTTTGCCAGGGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63057	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				GCTGACCAAAGCAAAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63058	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				GCTGACCAAAGCAAAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63059	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				GCTGACCAAAGCAAAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63060	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				GCTGACCAAAGCAAAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63061	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				TCTGCTGTCTTCATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63062	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				TCTGCTGTCTTCATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63063	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				TCTGCTGTCTTCATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63064	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				TCTGCTGTCTTCATTGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63065	hg19	N/A	N/A	N/A	Enhatls120369	enhancer	E_738				GCAGGCTGAGTCTGAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63066	hg19	N/A	enh54008	N/A	Enhatls120369	enhancer	E_738				GCAGGCTGAGTCTGAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63067	hg19	N/A	enh54008	N/A	N/A	enhancer	E_738				GCAGGCTGAGTCTGAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112488	chr3	12440277	12449313	12398778	12407814	63068	hg19	N/A	enh54008	N/A	Enhatls120370	enhancer	E_738				GCAGGCTGAGTCTGAAACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	617
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63069	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TGGACAGAGTGGTCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63070	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TGGACAGAGTGGTCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63071	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TGGACAGAGTGGTCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63072	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				CTAACTATCCGCATCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63073	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				CTAACTATCCGCATCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63074	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				CTAACTATCCGCATCATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63075	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GTAGCCAATGCAAGTGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63076	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GTAGCCAATGCAAGTGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63077	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GTAGCCAATGCAAGTGAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63078	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GGCCCAGTCAGAAACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63079	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GGCCCAGTCAGAAACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63080	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GGCCCAGTCAGAAACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63081	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TTTTTAATTTCTGTCCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63082	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TTTTTAATTTCTGTCCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63083	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TTTTTAATTTCTGTCCCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63084	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TGTTGTTGTTTGGTTTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63085	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TGTTGTTGTTTGGTTTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63086	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TGTTGTTGTTTGGTTTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63087	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GACCCCAGCCCTAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63088	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GACCCCAGCCCTAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63089	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GACCCCAGCCCTAAAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63090	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				CTAAAGGTTTGAGCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63091	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				CTAAAGGTTTGAGCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63092	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				CTAAAGGTTTGAGCTCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63093	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TTTTGGTGTTACTTAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63094	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TTTTGGTGTTACTTAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63095	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TTTTGGTGTTACTTAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63096	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				AAGACTCTAGCCAGTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63097	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				AAGACTCTAGCCAGTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63098	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				AAGACTCTAGCCAGTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63099	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GCTGATGGTCAGGGATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63100	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GCTGATGGTCAGGGATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63101	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GCTGATGGTCAGGGATCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63102	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TCAAGAAAGCTTGTAAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63103	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TCAAGAAAGCTTGTAAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63104	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TCAAGAAAGCTTGTAAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63105	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				ACAGCTCCGATAATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63106	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				ACAGCTCCGATAATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63107	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				ACAGCTCCGATAATGTGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63108	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				CTGACTTTTTCCCTGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63109	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				CTGACTTTTTCCCTGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63110	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				CTGACTTTTTCCCTGTGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63111	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GTTAACTTATGATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63112	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GTTAACTTATGATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63113	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GTTAACTTATGATTCATCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63114	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TGGGCTCCACACACAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63115	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TGGGCTCCACACACAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63116	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TGGGCTCCACACACAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63117	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TGTTTATGCTGCCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63118	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TGTTTATGCTGCCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63119	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TGTTTATGCTGCCCCAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63120	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				AGACGCGCACACCGTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63121	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				AGACGCGCACACCGTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63122	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				AGACGCGCACACCGTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63123	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				AATAAAACTCTCTCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63124	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				AATAAAACTCTCTCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63125	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				AATAAAACTCTCTCTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63126	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GGGTCCAGGGATGCAGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63127	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GGGTCCAGGGATGCAGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63128	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GGGTCCAGGGATGCAGATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63129	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TCTGATTGATGCGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63130	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TCTGATTGATGCGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63131	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TCTGATTGATGCGAAAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63132	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GACCTAACAGGGCCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63133	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GACCTAACAGGGCCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63134	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GACCTAACAGGGCCATATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63135	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TAACAGTACTAATAACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63136	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TAACAGTACTAATAACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63137	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TAACAGTACTAATAACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63138	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GGGGGACCTCCAATAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63139	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GGGGGACCTCCAATAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63140	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GGGGGACCTCCAATAGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63141	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GTCACCACTACCTGCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63142	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GTCACCACTACCTGCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63143	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GTCACCACTACCTGCTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63144	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GTAAAGAGACGTGATTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63145	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GTAAAGAGACGTGATTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63146	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GTAAAGAGACGTGATTGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63147	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GCACCGGGAGATCACTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63148	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GCACCGGGAGATCACTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63149	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GCACCGGGAGATCACTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63150	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GGGAGGCTCCCCAGGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63151	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GGGAGGCTCCCCAGGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63152	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GGGAGGCTCCCCAGGCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63153	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TTTGAGGCTGGCTGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63154	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TTTGAGGCTGGCTGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63155	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TTTGAGGCTGGCTGGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63156	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				GAGAGAGAGTGCACAGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63157	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				GAGAGAGAGTGCACAGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63158	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				GAGAGAGAGTGCACAGAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112489	chr3	12475087	12498973	12433588	12457474	63159	hg19	N/A	N/A	N/A	Enhatls120371	enhancer	E_739				TGCCTGGCAGGAGAAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	618
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63160	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_739				TGCCTGGCAGGAGAAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	6				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12475087	12498973	12433588	12457474	63161	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_739				TGCCTGGCAGGAGAAATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63162	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63163	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63164	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63165	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63166	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63167	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63168	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63169	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63170	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				ACTTGTTGAATGGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63171	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63172	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63173	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63174	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63175	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63176	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63177	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63178	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63179	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGACTCTCGGGAGAAAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63180	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63181	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63182	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63183	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63184	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63185	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63186	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63187	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63188	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GGATGTCATCCAGTGGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63189	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63190	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63191	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63192	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63193	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63194	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63195	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63196	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63197	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GCCTTGTCTGATAAGAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63198	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63199	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63200	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63201	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63202	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63203	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63204	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63205	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63206	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				CTCACCTGATTCCCTTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63207	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63208	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63209	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63210	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63211	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63212	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63213	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63214	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63215	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TATCAGCCACAACGATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63216	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63217	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63218	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63219	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63220	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63221	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63222	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63223	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63224	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				AGCGATGTGGATACAGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63225	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63226	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63227	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63228	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63229	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63230	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63231	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63232	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63233	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				CCTAGGTGCGTTCCAGAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63234	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63235	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63236	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63237	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63238	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63239	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63240	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63241	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63242	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				CATAGAGAAACCCCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63243	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63244	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63245	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63246	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63247	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63248	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63249	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63250	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63251	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				AGGAGATCACAGACACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63252	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63253	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63254	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63255	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63256	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63257	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63258	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63259	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63260	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TTCAAGTTCACTGCCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63261	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63262	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63263	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63264	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63265	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63266	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63267	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63268	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63269	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GCTCACGCAGCCAGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63270	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63271	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63272	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63273	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63274	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63275	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63276	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63277	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63278	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGCAGTTAAGGGACAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63279	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63280	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63281	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63282	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63283	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63284	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63285	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63286	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63287	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGTGTACGCTGCAGCATGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63288	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63289	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63290	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63291	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63292	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63293	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63294	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63295	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63296	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				AGATGAGATCAGTTTCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63297	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63298	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63299	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63300	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63301	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63302	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63303	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63304	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63305	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TCAAACATCCCATCCACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63306	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63307	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63308	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63309	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63310	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63311	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63312	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63313	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63314	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGCGTCTTGCAGGATCGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63315	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63316	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63317	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63318	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63319	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63320	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63321	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63322	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63323	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGGCGGAGTGCGCCTGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63324	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63325	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63326	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63327	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63328	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63329	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63330	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63331	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63332	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GCCGCACTGCTTGACGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63333	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63334	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63335	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63336	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63337	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63338	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63339	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63340	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63341	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GCGTGGGGCCAAGAAAGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63342	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63343	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63344	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63345	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63346	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63347	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63348	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63349	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63350	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GTTTGGTGTTTTGCAGCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63351	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63352	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63353	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63354	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63355	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63356	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63357	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63358	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63359	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				GGCGCACGAGGAAAGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63360	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63361	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63362	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63363	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63364	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63365	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63366	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63367	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63368	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TGGTGGAGTTCGGTCGGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63369	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					PPARG	chr3	12287367	12434356	171				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63370	hg19	N/A	enh20341	fant11195	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	21474				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63371	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	13080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63372	hg19	N/A	enh20341	fant11196	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	12795				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63373	hg19	N/A	enh20341	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10772				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63374	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	10247				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63375	hg19	N/A	enh35193	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	5685				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112490	chr3	12500141	12527262	12458642	12485763	63376	hg19	N/A	N/A	N/A	Enhatls120372	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	4990				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	619
enhrx-112491	chr3	12500141	12527262	12458642	12485763	63377	hg19	N/A	N/A	N/A	Enhatls120373	enhancer	E_740				TAAGACAGGGAGTTAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					TSEN2	chr3	12484420	12539644	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	620
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63378	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				CAGATGCATAACACCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63379	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				GCATTTTGTGAGCCTGATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63380	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				TAGGTAGCGCCCTGTAATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63381	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				TGAACTCTCACCTAGTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63382	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				TGCAAAATGGTATAGTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63383	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				GACGTAGGTTTTCATTCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63384	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				CATTCATAATTGCTAATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63385	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				CAGCAGGCGAATGGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63386	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				CTTGGTATCTTGCTTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	indirect	Non Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63387	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				CTCCCAACTATATGAAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63388	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				ATCAGTGGTTGACGGAAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112506	chr3	12590474	12592073	12548975	12550574	63389	hg19	N/A	N/A	N/A	Enhatls120388	enhancer	E_741				TTTTGCCCAGGCTTACTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2OS	chr3	12539775	12545499	5041				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	635
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63390	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				TAGCTTACTAAGATCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63391	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				TAGCTTACTAAGATCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63392	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				TAGCTTACTAAGATCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63393	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				TAGCTTACTAAGATCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63394	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				TAGCTTACTAAGATCTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63395	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				AAAACAGCTGAGCTAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63396	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				AAAACAGCTGAGCTAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63397	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				AAAACAGCTGAGCTAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63398	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				AAAACAGCTGAGCTAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63399	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				AAAACAGCTGAGCTAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63400	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CTAGCTGCTTAGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63401	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CTAGCTGCTTAGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63402	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CTAGCTGCTTAGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63403	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CTAGCTGCTTAGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63404	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				CTAGCTGCTTAGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63405	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				ATTGTATGAACTGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63406	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				ATTGTATGAACTGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63407	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				ATTGTATGAACTGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63408	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				ATTGTATGAACTGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63409	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				ATTGTATGAACTGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63410	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				GTGATACATGTAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63411	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				GTGATACATGTAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63412	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				GTGATACATGTAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63413	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				GTGATACATGTAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63414	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				GTGATACATGTAGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63415	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				TGCCTGAGTTGGAGTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63416	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				TGCCTGAGTTGGAGTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63417	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				TGCCTGAGTTGGAGTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63418	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				TGCCTGAGTTGGAGTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63419	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				TGCCTGAGTTGGAGTCCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63420	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				AGCTGGGTGACAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63421	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				AGCTGGGTGACAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63422	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				AGCTGGGTGACAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63423	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				AGCTGGGTGACAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63424	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				AGCTGGGTGACAGAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63425	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CTCCACACTAAGCTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63426	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CTCCACACTAAGCTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63427	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CTCCACACTAAGCTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63428	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CTCCACACTAAGCTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63429	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				CTCCACACTAAGCTTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63430	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				ATAGGGCAAAAGGAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63431	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				ATAGGGCAAAAGGAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63432	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				ATAGGGCAAAAGGAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63433	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				ATAGGGCAAAAGGAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63434	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				ATAGGGCAAAAGGAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63435	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CAGCAGGTTGAACAACCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112513	chr3	12625140	12628829	12583641	12587330	63436	hg19	N/A	N/A	N/A	Enhatls120395	enhancer	E_742				CAGCAGGTTGAACAACCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	642
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63437	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CAGCAGGTTGAACAACCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					MKRN2	chr3	12557086	12585792	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112514	chr3	12625140	12628829	12583641	12587330	63438	hg19	N/A	N/A	N/A	Enhatls120396	enhancer	E_742				CAGCAGGTTGAACAACCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	643
enhrx-112515	chr3	12625140	12628829	12583641	12587330	63439	hg19	N/A	N/A	N/A	Enhatls120397	enhancer	E_742				CAGCAGGTTGAACAACCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"RAF1,IQSEC1"	direct	Highly Significant	NA					RAF1	chr3	12582100	12664187	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	644
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63440	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				ACTATGCATCGGGATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63441	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				TTTCTCATCGGAAAATGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63442	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				CCAGAAACGATTTATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63443	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				GGGTTGTTATGAACCCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63444	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				CTTGGTTTGTCACTGCTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63445	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				TGTCCGGTAGGAATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63446	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				ATCTGCTTTTGAACTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63447	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				TGTTGACCACTCTTTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63448	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				TAGACACCCATTCCAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37976362	37979087	37934871	37937596	63449	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_745				GGAACTCTTTCTGAAGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63450	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				TCAGATGGAAATTCTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63451	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				TCAGATGGAAATTCTGAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63452	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				ACCCCCAAAACATTCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63453	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				ACCCCCAAAACATTCAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63454	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				ACTCGTAAGTGCACAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63455	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				ACTCGTAAGTGCACAAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63456	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				GCAGGCAAGGGACCATGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63457	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				GCAGGCAAGGGACCATGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63458	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				ACCACTGATCCGCCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63459	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				ACCACTGATCCGCCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63460	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				TGAAAAACACCCCTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63461	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				TGAAAAACACCCCTCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63462	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				CCTGCTCTGAACTAAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63463	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				CCTGCTCTGAACTAAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63464	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				CTGGCTGGCCCTACTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63465	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				CTGGCTGGCCCTACTTGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	direct	Highly Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63466	hg19	N/A	enh20502	N/A	Enhatls121565	enhancer	E_746				TCTTGGCGAGTTTAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	indirect	Non Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-113611	chr3	37986134	37988527	37944643	37947036	63467	hg19	N/A	N/A	N/A	Enhatls121565	enhancer	E_746				TCTTGGCGAGTTTAAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGA9	indirect	Non Significant	NA					CTDSPL	chr3	37861879	37984469	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1740
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63468	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GCAGTGAACACACAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63469	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GCAGTGAACACACAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63470	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GCAGTGAACACACAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63471	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GCAGTGAACACACAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63472	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				TTGACCTTCTAGGTCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63473	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				TTGACCTTCTAGGTCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63474	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				TTGACCTTCTAGGTCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63475	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				TTGACCTTCTAGGTCCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63476	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GGCGAAATGCGGCTTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63477	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GGCGAAATGCGGCTTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63478	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GGCGAAATGCGGCTTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63479	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GGCGAAATGCGGCTTGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63480	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GGGTGAAGTGCGTCACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63481	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GGGTGAAGTGCGTCACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63482	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GGGTGAAGTGCGTCACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63483	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GGGTGAAGTGCGTCACCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63484	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				CTGGCGCCGCCAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63485	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				CTGGCGCCGCCAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63486	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				CTGGCGCCGCCAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63487	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				CTGGCGCCGCCAGTGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63488	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				ACGCACGCACGAAGCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63489	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				ACGCACGCACGAAGCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63490	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				ACGCACGCACGAAGCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63491	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				ACGCACGCACGAAGCAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63492	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				CCTGCGGCTGGAGCACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63493	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				CCTGCGGCTGGAGCACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63494	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				CCTGCGGCTGGAGCACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63495	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				CCTGCGGCTGGAGCACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	indirect	Non Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63496	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GGCGCTGACTACCCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63497	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GGCGCTGACTACCCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63498	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GGCGCTGACTACCCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63499	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GGCGCTGACTACCCCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63500	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				CTGCCGGAGTGCACAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63501	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				CTGCCGGAGTGCACAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63502	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				CTGCCGGAGTGCACAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63503	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				CTGCCGGAGTGCACAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63504	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GATCTTAATTAAATGTAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63505	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GATCTTAATTAAATGTAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63506	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GATCTTAATTAAATGTAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63507	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GATCTTAATTAAATGTAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63508	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GTAAAAATGTAATAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63509	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GTAAAAATGTAATAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63510	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GTAAAAATGTAATAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63511	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GTAAAAATGTAATAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63512	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				GTCAGCTGAGAAGGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63513	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				GTCAGCTGAGAAGGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63514	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				GTCAGCTGAGAAGGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63515	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				GTCAGCTGAGAAGGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63516	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				TATCTAGGCTTCTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63517	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				TATCTAGGCTTCTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63518	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				TATCTAGGCTTCTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63519	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				TATCTAGGCTTCTCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63520	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				CTGGCTCATTTCTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63521	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				CTGGCTCATTTCTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63522	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				CTGGCTCATTTCTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63523	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				CTGGCTCATTTCTCAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63524	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				CTTGTGTTAGCCATTGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63525	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				CTTGTGTTAGCCATTGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63526	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				CTTGTGTTAGCCATTGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63527	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				CTTGTGTTAGCCATTGTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63528	hg19	N/A	enh7197	N/A	N/A	enhancer	E_747				TTTAGGATCTTAATAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63529	hg19	N/A	enh7197	N/A	Enhatls122672	enhancer	E_747				TTTAGGATCTTAATAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114637	chr3	48281208	48290406	48239718	48248916	63530	hg19	N/A	N/A	N/A	Enhatls122672	enhancer	E_747				TTTAGGATCTTAATAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2766
enhrx-114638	chr3	48281208	48290406	48239718	48248916	63531	hg19	N/A	N/A	N/A	Enhatls122673	enhancer	E_747				TTTAGGATCTTAATAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					ZNF589	chr3	48241099	48299253	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2767
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63532	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CTAGCCAGACAAAAACGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63533	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				TGGAACCATCTTGAGTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63534	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				TGGAGAACAACCCCTCGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63535	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CGGCTGCACAGTTCTGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63536	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CCTTTGGGACGGGTAAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63537	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CATTCTGAAACTGCTGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63538	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				GATGTTATACTCTAAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63539	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CCAACTCCCGGAAGGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63540	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				TGCAGAACTGCACTGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63541	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				CATGGCCAAGAAGGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63542	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				ACCAGTCAGTCTATGCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-114805	chr3	48775156	48778756	48737723	48741323	63543	hg19	N/A	N/A	N/A	Enhatls122845	enhancer	E_748				AGGCTACAGTATGAGACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					PRKAR2A	chr3	48744596	48847874	2302				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2934
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63544	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				CAAACGTACACATATTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63545	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GGAGGGCGAGATCCGGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63546	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GCTGGGGACTAGCCGGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63547	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GAGTTGACTGCCAGCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63548	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GGCCATGTCTGTGTACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63549	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				CGAAAGCTATCTTCCTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63550	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				TTTCCCACAATGCACCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63551	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				AGGCCCCTAGAAGGCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63552	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				ACTTGAAATGAACTGCTAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63553	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GACTGGATAAATGTCATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63554	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				TATACTGATACATTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115036	chr3	49964664	49968923	49927231	49931490	63555	hg19	N/A	N/A	N/A	Enhatls123082	enhancer	E_752				GACGGCACATAGAATAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARIH2	direct	Highly Significant	NA					MON1A	chr3	49907159	49930173	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3165
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63556	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				AAATATATTTGCTGAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63557	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				AAATATATTTGCTGAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63558	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				ACTTCTTACTCAGCCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63559	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				ACTTCTTACTCAGCCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63560	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				TGTAATTTCACATTACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63561	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				TGTAATTTCACATTACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63562	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				GGTTCTTGTTATCACACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63563	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				GGTTCTTGTTATCACACTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63564	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				GGTTGGATGAATACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63565	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				GGTTGGATGAATACCCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63566	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				ACTTAACACAGCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63567	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				ACTTAACACAGCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63568	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				TATGCCCTCACCACCCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63569	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				TATGCCCTCACCACCCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63570	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				GGGAAGTTAAGTAAATGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63571	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				GGGAAGTTAAGTAAATGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63572	hg19	N/A	enh7237	fant12209	Enhatls123952	enhancer	E_754				TCACAAGAACTTTTTGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115851	chr3	56957719	56963704	56923691	56929676	63573	hg19	N/A	enh7237	N/A	Enhatls123952	enhancer	E_754				TCACAAGAACTTTTTGCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3980
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63574	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GTATGGTGTGGGAGACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63575	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GTATGGTGTGGGAGACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63576	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				AATTTTAGTTTCTTTAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63577	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				AATTTTAGTTTCTTTAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63578	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				ATTCTCATCTGCATCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63579	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				ATTCTCATCTGCATCATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63580	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				TTGAAGGGATGTTTTGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63581	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				TTGAAGGGATGTTTTGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63582	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GCGGGTCAGCACTTTGAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63583	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GCGGGTCAGCACTTTGAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63584	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GATGATTCAGATGGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63585	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GATGATTCAGATGGATGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63586	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				AACTAATTATCCTTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63587	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				AACTAATTATCCTTTCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63588	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				ATACACTCTCGGGAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63589	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				ATACACTCTCGGGAAAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63590	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GGCCCTCAGTGTCGGTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63591	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GGCCCTCAGTGTCGGTGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63592	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GCAGTGGTGCTGATGAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63593	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GCAGTGGTGCTGATGAGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63594	hg19	N/A	enh7239	N/A	Enhatls123956	enhancer	E_755				GTCATAGAGAACGTTGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115853	chr3	57007924	57011476	56973896	56977448	63595	hg19	N/A	N/A	N/A	Enhatls123956	enhancer	E_755				GTCATAGAGAACGTTGTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					ARHGEF3	chr3	56727417	57079308	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3982
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63596	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				CACAGAGGGTCTGGAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63597	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CACAGAGGGTCTGGAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63598	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				CACAGAGGGTCTGGAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63599	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CACAGAGGGTCTGGAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63600	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				CACAGAGGGTCTGGAGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63601	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				AGTATTACCCCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63602	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				AGTATTACCCCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63603	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				AGTATTACCCCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63604	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				AGTATTACCCCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63605	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				AGTATTACCCCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63606	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				GGGGACACCACATTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63607	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				GGGGACACCACATTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63608	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				GGGGACACCACATTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63609	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				GGGGACACCACATTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63610	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				GGGGACACCACATTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63611	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				CTCGGCCCAGGGCGGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63612	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CTCGGCCCAGGGCGGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63613	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				CTCGGCCCAGGGCGGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63614	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CTCGGCCCAGGGCGGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63615	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				CTCGGCCCAGGGCGGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63616	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				TTCGGAGCAGCACAGACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63617	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TTCGGAGCAGCACAGACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63618	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				TTCGGAGCAGCACAGACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63619	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TTCGGAGCAGCACAGACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63620	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				TTCGGAGCAGCACAGACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63621	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				AAGGAGCAGTTAGAGCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63622	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				AAGGAGCAGTTAGAGCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63623	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				AAGGAGCAGTTAGAGCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63624	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				AAGGAGCAGTTAGAGCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63625	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				AAGGAGCAGTTAGAGCAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63626	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				CTTTGTTCATGAATGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63627	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CTTTGTTCATGAATGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63628	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				CTTTGTTCATGAATGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63629	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				CTTTGTTCATGAATGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63630	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				CTTTGTTCATGAATGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63631	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				GTGTTTTCCAGCTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63632	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				GTGTTTTCCAGCTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63633	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				GTGTTTTCCAGCTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63634	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				GTGTTTTCCAGCTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63635	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				GTGTTTTCCAGCTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63636	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				TTTTTAAGCCTCCCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63637	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TTTTTAAGCCTCCCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63638	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				TTTTTAAGCCTCCCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63639	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TTTTTAAGCCTCCCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63640	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				TTTTTAAGCCTCCCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63641	hg19	N/A	enh20649	N/A	Enhatls124094	enhancer	E_758				TGGCTTGAGTGCCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63642	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TGGCTTGAGTGCCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63643	hg19	N/A	enh20649	N/A	Enhatls124095	enhancer	E_758				TGGCTTGAGTGCCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63644	hg19	N/A	enh20649	N/A	N/A	enhancer	E_758				TGGCTTGAGTGCCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-115985	chr3	58088620	58091111	58102893	58105384	63645	hg19	N/A	enh20649	N/A	Enhatls124096	enhancer	E_758				TGGCTTGAGTGCCAACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ARHGEF3	direct	Highly Significant	NA					FLNB	chr3	58008399	58172251	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4114
enhrx-lit806	chr3	69099652	69102713	69050501	69053562	63646	hg19					enhancer	E_759				GCGCTTGGTAGCGCGTAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit807	chr3	69099652	69102713	69050501	69053562	63647	hg19					enhancer	E_759				GTACGTAAATCATCAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit808	chr3	69099652	69102713	69050501	69053562	63648	hg19					enhancer	E_759				CCGAGACGCGAAGCAATTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit809	chr3	69099652	69102713	69050501	69053562	63649	hg19					enhancer	E_759				GGGTGCGAGGCTTGTGGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit810	chr3	69099652	69102713	69050501	69053562	63650	hg19					enhancer	E_759				AGGTTAAGTGGTGTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit811	chr3	69099652	69102713	69050501	69053562	63651	hg19					enhancer	E_759				ACCCGGCTCTCCATACGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit812	chr3	69099652	69102713	69050501	69053562	63652	hg19					enhancer	E_759				GGCCCAGAAGTCTATTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit813	chr3	69099652	69102713	69050501	69053562	63653	hg19					enhancer	E_759				GTGGCGGCGGCAGCACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit814	chr3	69099652	69102713	69050501	69053562	63654	hg19					enhancer	E_759				GAACCAGCCGAGTGGAAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit815	chr3	69099652	69102713	69050501	69053562	63655	hg19					enhancer	E_759				CAGCTGTGCGGGAACGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit816	chr3	69099652	69102713	69050501	69053562	63656	hg19					enhancer	E_759				CCCAGAGTTCGGTCGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit817	chr3	69099652	69102713	69050501	69053562	63657	hg19					enhancer	E_759				CCGTTAGTTACCGAGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit818	chr3	69099652	69102713	69050501	69053562	63658	hg19					enhancer	E_759				TACAGCAGTTCTTAGCGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit819	chr3	69099652	69102713	69050501	69053562	63659	hg19					enhancer	E_759				TTGCCAGCAATAATTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit820	chr3	69099652	69102713	69050501	69053562	63660	hg19					enhancer	E_759				GTAAGGAGAAACACTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit821	chr3	69099652	69102713	69050501	69053562	63661	hg19					enhancer	E_759				TGTCCAACTCGTGGAACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit822	chr3	69099652	69102713	69050501	69053562	63662	hg19					enhancer	E_759				CCGACAGACCACAGTATTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63663	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				CTTGTTACTTTGCTCCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63664	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				GTAACTGAGGTGAGTGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63665	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				GTTTAGCCAAGCTGAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63666	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				GCACCCAGTCTCCCTTCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63667	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				AGGCTGACTCAGAGGCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63668	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				CACTATCTCCAGAATAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63669	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				TCATCGAGACAATTCGACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116427	chr3	69412756	69414457	69363605	69365306	63670	hg19	N/A	enh20682	N/A	Enhatls124592	enhancer	E_761				CAGGGGTTTTTGAGCTTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FRMD4B	chr3	69168781	69542583	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4556
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63671	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTAAGTGTGGCCAATAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63672	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TTAAGTGTGGCCAATAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63673	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTAAGTGTGGCCAATAAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63674	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				AGTGCATGTGATGAAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63675	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				AGTGCATGTGATGAAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63676	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				AGTGCATGTGATGAAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63677	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TCCACTCCTGAATTCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63678	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TCCACTCCTGAATTCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63679	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TCCACTCCTGAATTCTAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63680	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTAGCAGTTATGTGTGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63681	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TTAGCAGTTATGTGTGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63682	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTAGCAGTTATGTGTGAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63683	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TGTACTACTAAGAAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63684	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TGTACTACTAAGAAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63685	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TGTACTACTAAGAAACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63686	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GTTGAATCTGTATCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63687	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				GTTGAATCTGTATCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63688	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GTTGAATCTGTATCTGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63689	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GAAAAAAAGAAAAAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63690	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				GAAAAAAAGAAAAAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63691	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GAAAAAAAGAAAAAAAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63692	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TAGGAGATCCATGTGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63693	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TAGGAGATCCATGTGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63694	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TAGGAGATCCATGTGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63695	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				ATCAGTGGTGTAATTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63696	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				ATCAGTGGTGTAATTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63697	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				ATCAGTGGTGTAATTTTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63698	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				ATAAATAACAAGAATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63699	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				ATAAATAACAAGAATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63700	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				ATAAATAACAAGAATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63701	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TCATCACAGCAACCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63702	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TCATCACAGCAACCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63703	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TCATCACAGCAACCCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63704	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GAGAAAACTGAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63705	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				GAGAAAACTGAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63706	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GAGAAAACTGAGGTTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63707	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				CTCTAAAAAGAAGTTAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63708	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				CTCTAAAAAGAAGTTAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63709	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				CTCTAAAAAGAAGTTAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63710	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TAGGTTTCTGCTTCTGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63711	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TAGGTTTCTGCTTCTGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63712	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TAGGTTTCTGCTTCTGTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63713	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GACATTTGCTGTACGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63714	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				GACATTTGCTGTACGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63715	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GACATTTGCTGTACGCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63716	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				CAAATGTGAAAGTTTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63717	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				CAAATGTGAAAGTTTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63718	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				CAAATGTGAAAGTTTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63719	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GGATTTCACAATCCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63720	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				GGATTTCACAATCCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63721	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				GGATTTCACAATCCCCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63722	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTTTCTTCTTAACAGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63723	hg19	N/A	enh35520	fant12453	Enhatls124595	enhancer	E_763				TTTTCTTCTTAACAGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116431	chr3	69831415	69841071	69782264	69791920	63724	hg19	N/A	enh35520	N/A	Enhatls124595	enhancer	E_763				TTTTCTTCTTAACAGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					MITF	chr3	69739455	69968336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4560
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63725	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				GAAGGAGTGAACAGGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63726	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				GGAGATGGTTGGCTCCAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63727	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				CATTAGCCCTGCATAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63728	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				CATATAGAGGAATTACACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63729	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				ACTTGCAATAATGACAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63730	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				AGCCTGATAATGAGCAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63731	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				CACCTGAGCCAGAAAAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63732	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				GAGACTCGGGCAAAAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	indirect	Non Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63733	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				ATTGGCAGCCTCGAACCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-116446	chr3	70981567	70983349	70932416	70934198	63734	hg19	N/A	enh35531	N/A	Enhatls124611	enhancer	E_766				GTCTGATACTAAGCATTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MITF	direct	Highly Significant	NA					FOXP1	chr3	70954692	71583978	19329				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4575
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63735	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				TTCCCATTTAGAAACATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63736	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				ATGAGTTATAGCTATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63737	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				ACATTGATGTGTGATGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63738	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				ATGCAGTGAATCATGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63739	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				ATGCAAGTGCCCAAAGTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63740	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				ACAGTCCACCAGTGACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63741	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				TCATAAATCCCACTGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63742	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				TCTCGTGCTCTAGAACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63743	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				CATCTGTCACCTCATGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118300	chr3	124146182	124149338	124427335	124430491	63744	hg19	N/A	enh97342	N/A	Enhatls126580	enhancer	E_767				TGTTCTGGTGACCAGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6429
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63745	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				CAGTGAAGCAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63746	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				CAGTGAAGCAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63747	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				CAGTGAAGCAAACCAAATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63748	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				ATGTTGAATGAGATGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63749	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				ATGTTGAATGAGATGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63750	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				ATGTTGAATGAGATGGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63751	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GCCCAAGAAATGGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63752	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GCCCAAGAAATGGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63753	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GCCCAAGAAATGGTCAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63754	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GAAGAATCATATAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63755	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GAAGAATCATATAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63756	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GAAGAATCATATAGTCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63757	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GTGTTGGACAGAGATAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63758	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GTGTTGGACAGAGATAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63759	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GTGTTGGACAGAGATAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63760	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				ATGTAATGGCAGTCATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63761	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				ATGTAATGGCAGTCATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63762	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				ATGTAATGGCAGTCATCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63763	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GCTGAGGATTACTTGAAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63764	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GCTGAGGATTACTTGAAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63765	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GCTGAGGATTACTTGAAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63766	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TAGCAGTTCTTAAAACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63767	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				TAGCAGTTCTTAAAACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63768	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TAGCAGTTCTTAAAACAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63769	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TGCAATTATAGCCGACTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63770	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				TGCAATTATAGCCGACTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63771	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TGCAATTATAGCCGACTTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63772	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GAAAGGGAGAGAGTTATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63773	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GAAAGGGAGAGAGTTATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63774	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GAAAGGGAGAGAGTTATAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63775	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TCTTAGGGATGAGTATTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63776	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				TCTTAGGGATGAGTATTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63777	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TCTTAGGGATGAGTATTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63778	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GGATAAGCCAAGTTTTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63779	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GGATAAGCCAAGTTTTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63780	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GGATAAGCCAAGTTTTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63781	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GTAGTTTTATCCATAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63782	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GTAGTTTTATCCATAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63783	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GTAGTTTTATCCATAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63784	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				CAGTTTGGAGCATTTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63785	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				CAGTTTGGAGCATTTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63786	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				CAGTTTGGAGCATTTAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63787	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TACTCAATCACAAAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63788	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				TACTCAATCACAAAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63789	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TACTCAATCACAAAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63790	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TGATTTGTTGTTAACTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63791	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				TGATTTGTTGTTAACTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63792	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				TGATTTGTTGTTAACTGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63793	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GGACTCTAATATTTATATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63794	hg19	N/A	enh70835	N/A	Enhatls126598	enhancer	E_768				GGACTCTAATATTTATATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124246742	124251456	124527895	124532609	63795	hg19	N/A	N/A	N/A	Enhatls126598	enhancer	E_768				GGACTCTAATATTTATATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63796	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				ATGGACCGCTACATACATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63797	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				CCCTCCGCAATGCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63798	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				GGATTGGTCAGCAGGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63799	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				TTGGATGGTGACTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63800	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				AGGCCTTAGGCAGGGTTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63801	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				CAGGGACTCGCTGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63802	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				TTCCTACTCAGGGAGATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63803	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				TTACCCTACAGCATCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63804	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				TTGGAATTCGCTTCTTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63805	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				CCATTGAGGTGAAGTGAACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63806	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				CTGTATCTAAAGCTTGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63807	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				AGCCTAGATACGCCACTAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118317	chr3	124276406	124280764	124557559	124561917	63808	hg19	N/A	enh20873	N/A	Enhatls126598	enhancer	E_769				TGGGTTACAATCAGACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6446
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63809	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CCTCCCTGCATCGTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63810	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CCTCCCTGCATCGTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63811	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CCTCCCTGCATCGTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63812	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CCTCCCTGCATCGTTCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63813	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				AATCTAAGCATGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63814	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				AATCTAAGCATGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63815	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				AATCTAAGCATGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63816	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				AATCTAAGCATGGTTCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63817	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CCTGGAAGAAACACACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63818	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CCTGGAAGAAACACACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63819	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CCTGGAAGAAACACACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63820	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CCTGGAAGAAACACACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63821	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				GAGTGTTGTGTGTTTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63822	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				GAGTGTTGTGTGTTTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63823	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				GAGTGTTGTGTGTTTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63824	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				GAGTGTTGTGTGTTTCCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63825	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				ACACCCTGTGAGTAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63826	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				ACACCCTGTGAGTAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63827	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				ACACCCTGTGAGTAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63828	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				ACACCCTGTGAGTAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63829	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CTACTGGGCATATTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63830	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CTACTGGGCATATTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63831	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CTACTGGGCATATTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63832	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CTACTGGGCATATTGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63833	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				GATGTTCGAAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63834	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				GATGTTCGAAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63835	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				GATGTTCGAAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63836	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				GATGTTCGAAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63837	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CTTAGATGCTCCAAGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63838	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CTTAGATGCTCCAAGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63839	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CTTAGATGCTCCAAGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63840	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CTTAGATGCTCCAAGACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63841	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CCATTGTGGTGGCCTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63842	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CCATTGTGGTGGCCTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63843	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CCATTGTGGTGGCCTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63844	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CCATTGTGGTGGCCTTTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63845	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				TGCCTGTGGCACCAACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63846	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				TGCCTGTGGCACCAACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63847	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				TGCCTGTGGCACCAACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63848	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				TGCCTGTGGCACCAACGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63849	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				TTAGGCCCTCCCTCCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63850	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				TTAGGCCCTCCCTCCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63851	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				TTAGGCCCTCCCTCCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63852	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				TTAGGCCCTCCCTCCCCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63853	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				GCTGTGCTCTCCCCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63854	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				GCTGTGCTCTCCCCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63855	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				GCTGTGCTCTCCCCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63856	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				GCTGTGCTCTCCCCGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63857	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				GGCTGGCGCCCCGTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63858	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				GGCTGGCGCCCCGTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63859	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				GGCTGGCGCCCCGTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63860	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				GGCTGGCGCCCCGTGCCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63861	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				ACAGCCACTCACCTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63862	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				ACAGCCACTCACCTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63863	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				ACAGCCACTCACCTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63864	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				ACAGCCACTCACCTCTACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63865	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				GACTGGTCGCGCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63866	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				GACTGGTCGCGCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63867	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				GACTGGTCGCGCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63868	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				GACTGGTCGCGCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63869	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				AGGCCTCTGGGGTAGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63870	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				AGGCCTCTGGGGTAGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63871	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				AGGCCTCTGGGGTAGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63872	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				AGGCCTCTGGGGTAGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118318	chr3	124299317	124304858	124580470	124586011	63873	hg19	N/A	enh20874	N/A	N/A	enhancer	E_770				CGAGCGCGCGCGTTCTGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6447
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63874	hg19	N/A	N/A	N/A	Enhatls126600	enhancer	E_770				CGAGCGCGCGCGTTCTGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63875	hg19	N/A	enh20875	N/A	Enhatls126600	enhancer	E_770				CGAGCGCGCGCGTTCTGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-118319	chr3	124299317	124304858	124580470	124586011	63876	hg19	hs2031	enh20875	N/A	Enhatls126600	enhancer	E_770				CGAGCGCGCGCGTTCTGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ITGB5	direct	Highly Significant	NA					KALRN	chr3	124033368	124726325	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6448
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63877	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63878	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63879	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63880	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63881	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63882	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GGAAGTACAGAAGCGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63883	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63884	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63885	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63886	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63887	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63888	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				ATCCTGCGCATGCGTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63889	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63890	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63891	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63892	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63893	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63894	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				CCGGTTTCCCGATTGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63895	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63896	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63897	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63898	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63899	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63900	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				ACGGGGCGGAGTCCAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63901	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63902	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63903	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63904	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63905	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63906	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GCTTCGTCCTGGCACCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63907	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63908	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63909	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63910	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63911	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63912	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GCAGGCAGAGCAAAATACGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63913	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63914	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63915	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63916	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63917	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63918	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				CGAGAGTGCTCGGCTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63919	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63920	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63921	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63922	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63923	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63924	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GCAGCCTCGGGCGACAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63925	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63926	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63927	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63928	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63929	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63930	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GGCGTGCGCGGCGAGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63931	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63932	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63933	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63934	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63935	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63936	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				CGGCAGCGTGAGCGCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63937	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63938	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63939	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63940	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63941	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63942	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				CATCCGGGTCGAGGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63943	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63944	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63945	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63946	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63947	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63948	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				CGGCGGAAGCAGTGGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63949	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63950	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63951	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63952	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63953	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63954	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				ACGGCGGGACCGCCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63955	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63956	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63957	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63958	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63959	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63960	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GACGCTTCCCCGGCAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63961	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63962	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63963	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63964	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63965	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63966	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GGAGAGCCTGCGTCACGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63967	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63968	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63969	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63970	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63971	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63972	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GCGTCGCTCGGCGTTAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63973	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63974	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63975	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63976	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63977	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63978	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GATAAACGCTGCTCTGTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119124	chr3	133287320	133297008	133568476	133578164	63979	hg19	N/A	N/A	N/A	Enhatls127481	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	5100				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7253
enhrx-119125	chr3	133287320	133297008	133568476	133578164	63980	hg19	N/A	N/A	fant13547	N/A	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	3279				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7254
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63981	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63982	hg19	N/A	enh7553	N/A	Enhatls127482	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63983	hg19	N/A	enh7553	N/A	N/A	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119126	chr3	133287320	133297008	133568476	133578164	63984	hg19	N/A	enh7553	N/A	Enhatls127483	enhancer	E_771				GAAAATTCAGCTCAAACTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CDV3	chr3	133573685	133590261	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7255
enhrx-119219	chr3	134199424	134207401	134480582	134488559	63985	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				GGAGAGCAACACGTTAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	63986	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				GGAGAGCAACACGTTAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63987	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GGAGAGCAACACGTTAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63988	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GGAGAGCAACACGTTAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	63989	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				GGAGAGCAACACGTTAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	63990	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				GTTTGAGCCAGGGGCTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	63991	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				GTTTGAGCCAGGGGCTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63992	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GTTTGAGCCAGGGGCTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63993	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GTTTGAGCCAGGGGCTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	63994	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				GTTTGAGCCAGGGGCTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	63995	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				CGAACATACTGTAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	63996	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				CGAACATACTGTAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63997	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				CGAACATACTGTAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	63998	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				CGAACATACTGTAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	63999	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				CGAACATACTGTAAAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	64000	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				GCAGTATGAGGTTCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	64001	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				GCAGTATGAGGTTCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64002	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GCAGTATGAGGTTCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64003	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				GCAGTATGAGGTTCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	64004	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				GCAGTATGAGGTTCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	64005	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				ATTAGAGGAAGGAACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	64006	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				ATTAGAGGAAGGAACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64007	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				ATTAGAGGAAGGAACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64008	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				ATTAGAGGAAGGAACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	64009	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				ATTAGAGGAAGGAACCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	64010	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				TATAATCTAATCCAAAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	64011	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				TATAATCTAATCCAAAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64012	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				TATAATCTAATCCAAAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64013	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				TATAATCTAATCCAAAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	64014	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				TATAATCTAATCCAAAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	64015	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				ATGATGCCTATGATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	64016	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				ATGATGCCTATGATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64017	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				ATGATGCCTATGATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64018	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				ATGATGCCTATGATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	64019	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				ATGATGCCTATGATGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119219	chr3	134199424	134207401	134480582	134488559	64020	hg19	N/A	N/A	N/A	Enhatls127578	enhancer	E_772				CCAAAAAGCCCGGAAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7348
enhrx-119220	chr3	134199424	134207401	134480582	134488559	64021	hg19	N/A	N/A	fant13573	N/A	enhancer	E_772				CCAAAAAGCCCGGAAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7349
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64022	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				CCAAAAAGCCCGGAAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					ANAPC13	chr3	134477705	134486716	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119221	chr3	134199424	134207401	134480582	134488559	64023	hg19	N/A	N/A	N/A	Enhatls127579	enhancer	E_772				CCAAAAAGCCCGGAAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7350
enhrx-119222	chr3	134199424	134207401	134480582	134488559	64024	hg19	N/A	N/A	fant13574	N/A	enhancer	E_772				CCAAAAAGCCCGGAAGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7351
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64025	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				ATTTTTTTTTTTTTTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64026	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				ATTTTTTTTTTTTTTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64027	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				ATTTTTTTTTTTTTTGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64028	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				CCTAGAACTTGGGAGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64029	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				CCTAGAACTTGGGAGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64030	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				CCTAGAACTTGGGAGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64031	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				TATAAACAGCAAGATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64032	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				TATAAACAGCAAGATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64033	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				TATAAACAGCAAGATACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64034	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				GCTGTGACCAGTTTGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64035	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				GCTGTGACCAGTTTGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64036	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				GCTGTGACCAGTTTGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64037	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				CTCAACGCAGCATTTCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64038	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				CTCAACGCAGCATTTCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64039	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				CTCAACGCAGCATTTCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64040	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				CTAGACTATTCATCCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64041	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				CTAGACTATTCATCCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64042	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				CTAGACTATTCATCCCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64043	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				TCCACCGAAAGGCAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64044	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				TCCACCGAAAGGCAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64045	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				TCCACCGAAAGGCAGCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64046	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				AATGGGTTCACACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64047	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				AATGGGTTCACACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64048	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				AATGGGTTCACACATGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64049	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				GGTGGGATCTCTCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64050	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				GGTGGGATCTCTCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64051	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				GGTGGGATCTCTCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64052	hg19	N/A	enh113288	N/A	Enhatls127580	enhancer	E_773				ATACTAGGAACAAACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119223	chr3	134212453	134214538	134493611	134495696	64053	hg19	N/A	N/A	N/A	Enhatls127580	enhancer	E_773				ATACTAGGAACAAACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7352
enhrx-119224	chr3	134212453	134214538	134493611	134495696	64054	hg19	N/A	N/A	N/A	Enhatls127581	enhancer	E_773				ATACTAGGAACAAACTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	AMOTL2	direct	Highly Significant	NA					CEP63	chr3	134485698	134587789	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7353
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64055	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				GAACTCTCACAATAGGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64056	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				TGCAGGTTTCTTCTCGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64057	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				AGACCCAAACTACTTAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64058	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				AGACTCATAAAGAGGTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64059	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				ATAGCTGCAGAGCAGGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64060	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				GTCTTCCTGCCAGCAAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64061	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				GCGGCCTTCGGCTAAGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64062	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				TGAGAGGCGCGACAAACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64063	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				CGGCCCACAGAGCACAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64064	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				CGGGCCCGAGGCGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64065	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				CGGCGGCCATCTCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64066	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				GGTGATCCCAGACCTCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64067	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				GGAGGGTGCGGCAGGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64068	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				ACTTCTCACTGTCGAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119451	chr3	138326053	138328898	138607211	138610056	64069	hg19	N/A	N/A	N/A	Enhatls127820	enhancer	E_775				TTTTCCTTGTAACATGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SOX14	direct	Highly Significant	NA					FAIM	chr3	138608608	138633376	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7580
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64070	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				GTGGGAAGGGCGACTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64071	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				GTGGGAAGGGCGACTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64072	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				GTGGGAAGGGCGACTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64073	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				GTGGGAAGGGCGACTGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64074	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				TCTCTGCAGACCGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64075	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				TCTCTGCAGACCGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64076	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				TCTCTGCAGACCGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64077	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				TCTCTGCAGACCGTTGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64078	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				GTGGGATAGGCCGAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64079	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				GTGGGATAGGCCGAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64080	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				GTGGGATAGGCCGAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64081	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				GTGGGATAGGCCGAAAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64082	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				ACTAGGGCCCGGGCCGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64083	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				ACTAGGGCCCGGGCCGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64084	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				ACTAGGGCCCGGGCCGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64085	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				ACTAGGGCCCGGGCCGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64086	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				ACCACGACCACAGACGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64087	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				ACCACGACCACAGACGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64088	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				ACCACGACCACAGACGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64089	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				ACCACGACCACAGACGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64090	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				GCCCGTGGCTTTGCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64091	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				GCCCGTGGCTTTGCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64092	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				GCCCGTGGCTTTGCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64093	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				GCCCGTGGCTTTGCACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64094	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				GTTGCGGTGCGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64095	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				GTTGCGGTGCGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64096	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				GTTGCGGTGCGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64097	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				GTTGCGGTGCGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64098	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				GCGGCGCGCACCCGCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64099	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				GCGGCGCGCACCCGCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64100	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				GCGGCGCGCACCCGCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64101	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				GCGGCGCGCACCCGCCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64102	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				CGGGCGCGCAGCGACGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64103	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				CGGGCGCGCAGCGACGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64104	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				CGGGCGCGCAGCGACGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64105	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				CGGGCGCGCAGCGACGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64106	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				AGCAGCGCAGAGGTTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64107	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				AGCAGCGCAGAGGTTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64108	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				AGCAGCGCAGAGGTTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64109	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				AGCAGCGCAGAGGTTCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64110	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				CTGGGGGCGCTTCGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64111	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				CTGGGGGCGCTTCGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64112	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				CTGGGGGCGCTTCGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64113	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				CTGGGGGCGCTTCGAAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64114	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				TGGGACACCGGGCGCACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64115	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				TGGGACACCGGGCGCACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64116	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				TGGGACACCGGGCGCACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64117	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				TGGGACACCGGGCGCACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119565	chr3	140947834	140954338	141228992	141235496	64118	hg19	N/A	N/A	fant13660	N/A	enhancer	E_776				CGTGAGACGGCGCCAGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7694
enhrx-119566	chr3	140947834	140954338	141228992	141235496	64119	hg19	N/A	N/A	N/A	Enhatls127937	enhancer	E_776				CGTGAGACGGCGCCAGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7695
enhrx-119567	chr3	140947834	140954338	141228992	141235496	64120	hg19	N/A	N/A	N/A	Enhatls127938	enhancer	E_776				CGTGAGACGGCGCCAGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7696
enhrx-119568	chr3	140947834	140954338	141228992	141235496	64121	hg19	N/A	N/A	N/A	Enhatls127939	enhancer	E_776				CGTGAGACGGCGCCAGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64122	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				TGCTCACACACAGTCCAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64123	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				TCTTCAGCTGAGTGAGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64124	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				GTGTGAGCATACCTTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64125	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				AGAGAATCCTGATTTTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64126	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				TGGATATTGAGGGGCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64127	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				CTGGGGATGAAGACGACTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64128	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				TCATCTGGCCCAGTTCCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64129	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				CATGTCCTGTGTCAAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64130	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				AAGTGGTCTTTAGTCCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64131	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				ACCCCAACCCACATCTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119568	chr3	140955818	140962729	141236976	141243887	64132	hg19	N/A	enh20989	N/A	Enhatls127939	enhancer	E_777				CCACTCATCAATTATTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7697
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64133	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64134	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64135	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64136	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64137	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64138	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64139	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64140	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTCACTTTAAATGAAATTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64141	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64142	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64143	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64144	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64145	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64146	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64147	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64148	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTGCTATTAAGCCTATTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64149	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64150	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64151	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64152	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64153	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64154	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64155	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64156	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTTAAAGACTGTCTAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64157	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64158	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64159	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64160	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64161	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64162	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64163	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64164	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CGAGTAGCAGAAAATAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64165	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64166	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64167	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64168	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64169	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64170	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64171	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64172	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGGGCAGGCACAAATACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64173	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64174	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64175	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64176	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64177	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64178	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64179	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64180	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GACTGGCCTTGATGAGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64181	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64182	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64183	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64184	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64185	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64186	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64187	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64188	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCTACAGAGCCCCTCAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64189	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64190	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64191	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64192	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64193	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64194	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64195	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64196	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GCCATGTAGTGCCAACTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64197	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64198	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64199	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64200	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64201	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64202	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64203	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64204	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GAATGAGGAAAACAGGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64205	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64206	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64207	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64208	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64209	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64210	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64211	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64212	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				ATAAGTGCTCTTCAGTTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64213	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64214	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64215	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64216	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64217	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64218	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64219	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64220	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GTGGGATACGAGCCGACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64221	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64222	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64223	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64224	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64225	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64226	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64227	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64228	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCCATGATGGGGACGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64229	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64230	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64231	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64232	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64233	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64234	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64235	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64236	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				GGAACGTGAGAGACAGGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64237	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64238	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64239	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64240	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64241	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64242	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64243	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64244	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGCGATAGAACCCGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64245	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64246	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64247	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64248	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64249	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64250	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64251	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64252	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CCTTCCGCTTTCGAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64253	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64254	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64255	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64256	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64257	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64258	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64259	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64260	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TTTCTGAAGGGATAGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64261	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64262	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64263	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64264	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64265	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64266	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64267	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64268	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				AGAGAAACCCGGACTTAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64269	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64270	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64271	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64272	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64273	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64274	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64275	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64276	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TGTCGTTGAGTCGAGCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64277	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64278	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64279	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64280	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64281	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64282	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64283	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64284	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				TAGCTCCTGGCTTTTATGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64285	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	5434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64286	hg19	N/A	enh35922	fant13662	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	7835				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64287	hg19	N/A	enh35922	N/A	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	8137				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64288	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	10813				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64289	hg19	N/A	N/A	fant13663	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12226				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64290	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					PXYLP1	chr3	141228725	141294924	12314				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64291	hg19	N/A	N/A	fant13664	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	12173				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119574	chr3	141020050	141032615	141301208	141313773	64292	hg19	N/A	N/A	N/A	Enhatls127945	enhancer	E_779				CTACGGAGTGAGCGAGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ZBTB38	chr3	141324212	141449792	5005				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7703
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64293	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GAGTGTTCATATTTTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64294	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				GAGTGTTCATATTTTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64295	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GAGTGTTCATATTTTCACTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64296	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				TATGGGAATGACTCAGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64297	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				TATGGGAATGACTCAGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64298	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				TATGGGAATGACTCAGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64299	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGGCGAATCTAGTTACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64300	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				AGGCGAATCTAGTTACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64301	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGGCGAATCTAGTTACCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64302	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GGGGTCAGCCAGGAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64303	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				GGGGTCAGCCAGGAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64304	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GGGGTCAGCCAGGAACAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64305	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				ACTCTATCCTGCCACTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64306	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				ACTCTATCCTGCCACTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64307	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				ACTCTATCCTGCCACTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64308	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGCATTGACCCCAGTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64309	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				AGCATTGACCCCAGTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64310	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGCATTGACCCCAGTGTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64311	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				TGGCAGGAATTGAGATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64312	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				TGGCAGGAATTGAGATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64313	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				TGGCAGGAATTGAGATTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64314	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGAAGACCCCTTTATTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64315	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				AGAAGACCCCTTTATTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64316	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGAAGACCCCTTTATTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64317	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GATTTCTGGGGTTAACTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64318	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				GATTTCTGGGGTTAACTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64319	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GATTTCTGGGGTTAACTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64320	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				CTTGCCAAGTCTTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64321	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				CTTGCCAAGTCTTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64322	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				CTTGCCAAGTCTTTGTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64323	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GTAAATCTGGGAACCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64324	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				GTAAATCTGGGAACCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64325	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GTAAATCTGGGAACCACAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64326	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GCTCAGAAGCCATACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64327	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				GCTCAGAAGCCATACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64328	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				GCTCAGAAGCCATACTCTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64329	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGTCTTATACATAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	15500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64330	hg19	hs2041	enh54374	N/A	Enhatls127982	enhancer	E_781				AGTCTTATACATAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	14156				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119611	chr3	141576982	141581032	141858140	141862190	64331	hg19	N/A	enh54374	N/A	Enhatls127982	enhancer	E_781				AGTCTTATACATAGTGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					ATP1B3	chr3	141876123	141926549	9667				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64332	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				GGTGCACACCACGGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64333	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				GGTCTTGCTCTGTCACAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64334	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				TTTTTGTTGTACTCAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64335	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				CGAAAAGGTCCCATCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64336	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				TTTTGAGAGCCATGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64337	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				TTTAGGCCCCTTAGCCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64338	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				CTTCAGGACATTTTTGCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64339	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				TGAAGGAAGTCCTGTAGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64340	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				AGCTCAGCCTTCTCTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64341	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				GACGGCTGCCAAATGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64342	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				GGGAAGCTGGCGGTGTCGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119618	chr3	141658571	141660793	141939729	141941951	64343	hg19	N/A	enh35927	N/A	Enhatls127989	enhancer	E_782				GAAGGAATGGAGGCCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	95				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7747
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64344	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				TTGGATTCAACATTTAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64345	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				TTGGATTCAACATTTAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64346	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				TTGGATTCAACATTTAATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64347	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				TCTGAAACTTGCGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64348	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				TCTGAAACTTGCGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64349	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				TCTGAAACTTGCGAAATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64350	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				AAGATACTCAAACCTGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64351	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				AAGATACTCAAACCTGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64352	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				AAGATACTCAAACCTGCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64353	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				CTATAGTTTAAGTAACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64354	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				CTATAGTTTAAGTAACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64355	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				CTATAGTTTAAGTAACAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64356	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				GAGTCATTCTGCTCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64357	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				GAGTCATTCTGCTCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64358	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				GAGTCATTCTGCTCTGTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64359	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				CCTAACTCTGTTACAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64360	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				CCTAACTCTGTTACAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64361	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				CCTAACTCTGTTACAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64362	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				TCAAAGCTAACAGGCCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64363	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				TCAAAGCTAACAGGCCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64364	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				TCAAAGCTAACAGGCCAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64365	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				AATCCTGTCCTGAGAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64366	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				AATCCTGTCCTGAGAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64367	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				AATCCTGTCCTGAGAGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64368	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				CCCAACACACGTTAATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64369	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				CCCAACACACGTTAATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64370	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				CCCAACACACGTTAATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64371	hg19	N/A	enh95122	N/A	Enhatls127991	enhancer	E_783				ATCATGGGCCTCAGCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64372	hg19	N/A	enh95122	N/A	N/A	enhancer	E_783				ATCATGGGCCTCAGCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119619	chr3	141677428	141680513	141958586	141961671	64373	hg19	N/A	enh95122	N/A	Enhatls127992	enhancer	E_783				ATCATGGGCCTCAGCCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					TFDP2	chr3	141944427	142149544	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7748
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64374	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				AAGGTCTCACTATGTTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64375	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TCCCAAGTATCTGACACTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	direct	Highly Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64376	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				CTCACTATACCTCCACCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64377	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				GTTTATTTATTTACCAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64378	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				GATTCTCATCTGTCATTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64379	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TAGGTATTCACCCAAGATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64380	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				ATTTCCGGTTTGCCACTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64381	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TAGCTGTATTCTCCACACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64382	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				CAGTATGTATTGTTTGCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64383	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TGATATAAAGTTCTACAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64384	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				CTTAAGTGTACTAATTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64385	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TTCTTAGAATATGGGGTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64386	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				AGAAGCTTTGTTGTTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64387	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TGACAGCTGGGCCAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-119645	chr3	141989399	141992762	142270557	142273920	64388	hg19	N/A	enh35931	N/A	Enhatls128019	enhancer	E_784				TCATCTGCTCACACTGTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RNF7	indirect	Non Significant	NA					XRN1	chr3	142306606	142448062	30684				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7774
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64389	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				AAGTGAGGTTTAGGGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64390	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				AAGTGAGGTTTAGGGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64391	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				AAGTGAGGTTTAGGGGCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64392	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TGGACATGTAGAGAGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64393	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				TGGACATGTAGAGAGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64394	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TGGACATGTAGAGAGAAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64395	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GCTGCATGTACAAAGGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64396	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				GCTGCATGTACAAAGGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64397	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GCTGCATGTACAAAGGTTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64398	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GTATTCAGGGCCTATCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64399	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				GTATTCAGGGCCTATCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64400	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GTATTCAGGGCCTATCAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64401	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				AGCAAAGATGAGTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64402	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				AGCAAAGATGAGTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64403	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				AGCAAAGATGAGTCATTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	indirect	Non Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64404	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TCTGAGCTAAAGTATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64405	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				TCTGAGCTAAAGTATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64406	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TCTGAGCTAAAGTATTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64407	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GGGTTAGGTTACTGGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64408	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				GGGTTAGGTTACTGGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64409	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				GGGTTAGGTTACTGGGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64410	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				CCAAAGAAAAGAAGATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64411	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				CCAAAGAAAAGAAGATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64412	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				CCAAAGAAAAGAAGATTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64413	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TTATTCTGTATGTGTTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	174515				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64414	hg19	N/A	enh70946	fant14104	Enhatls129108	enhancer	E_785				TTATTCTGTATGTGTTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176693				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-120667	chr3	167989524	167991150	168271736	168273362	64415	hg19	N/A	enh70946	N/A	Enhatls129108	enhancer	E_785				TTATTCTGTATGTGTTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PDCD10	direct	Highly Significant	NA					GOLIM4	chr3	168008688	168095924	176773				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8796
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64416	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				TATACCAATCGACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64417	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				TATACCAATCGACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64418	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				TATACCAATCGACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64419	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CCGAGTGGTCTGTTTTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64420	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CCGAGTGGTCTGTTTTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64421	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CCGAGTGGTCTGTTTTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64422	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				ACAAAGCTTCCACAATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64423	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				ACAAAGCTTCCACAATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64424	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				ACAAAGCTTCCACAATAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64425	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CTGCCTTTATGAGCCGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64426	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CTGCCTTTATGAGCCGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64427	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CTGCCTTTATGAGCCGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64428	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				GAGTGTTACAGCTCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64429	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				GAGTGTTACAGCTCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64430	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				GAGTGTTACAGCTCTTAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64431	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CTCTAAGTTCCCAATGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64432	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CTCTAAGTTCCCAATGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64433	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CTCTAAGTTCCCAATGTGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64434	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				GTCGACTTCACGCTAGTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64435	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				GTCGACTTCACGCTAGTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64436	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				GTCGACTTCACGCTAGTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64437	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				AAAGAGCTGTGGCGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64438	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				AAAGAGCTGTGGCGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64439	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				AAAGAGCTGTGGCGCTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64440	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				GGTTCTCGCTTGCTGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64441	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				GGTTCTCGCTTGCTGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64442	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				GGTTCTCGCTTGCTGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64443	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				TTTGGATACCGTCCTCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64444	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				TTTGGATACCGTCCTCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64445	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				TTTGGATACCGTCCTCGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64446	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CTGCTCACCAGCAGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64447	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CTGCTCACCAGCAGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64448	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CTGCTCACCAGCAGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64449	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CCGTGGACGCGGACGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64450	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CCGTGGACGCGGACGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64451	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CCGTGGACGCGGACGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64452	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				CAGGTTCTCGCGGCCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64453	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				CAGGTTCTCGCGGCCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64454	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				CAGGTTCTCGCGGCCGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64455	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				GCTCGACGCCATCAAGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64456	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				GCTCGACGCCATCAAGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64457	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				GCTCGACGCCATCAAGAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123223	chr4	6674987	6679508	6673260	6677781	64458	hg19	N/A	N/A	N/A	Enhatls131856	enhancer	E_786				ACTCGCAGCCGGCGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	767
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64459	hg19	N/A	N/A	N/A	Enhatls131857	enhancer	E_786				ACTCGCAGCCGGCGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	7				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6674987	6679508	6673260	6677781	64460	hg19	N/A	enh86512	N/A	Enhatls131857	enhancer	E_786				ACTCGCAGCCGGCGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					MRFAP1L2	chr4	6674074	6676047	1305				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64461	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				GGAGGAAGGCCGCCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64462	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GGAGGAAGGCCGCCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64463	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				GGAGGAAGGCCGCCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64464	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GGAGGAAGGCCGCCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64465	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				GGAGGAAGGCCGCCAACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64466	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TCCTGCTCTGAGGCCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64467	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TCCTGCTCTGAGGCCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64468	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TCCTGCTCTGAGGCCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64469	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TCCTGCTCTGAGGCCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64470	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TCCTGCTCTGAGGCCCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64471	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TTCTCGGCTCCAGAACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64472	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TTCTCGGCTCCAGAACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64473	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TTCTCGGCTCCAGAACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64474	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TTCTCGGCTCCAGAACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64475	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TTCTCGGCTCCAGAACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64476	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				GGTGACTGAGTATTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64477	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GGTGACTGAGTATTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64478	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				GGTGACTGAGTATTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64479	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GGTGACTGAGTATTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64480	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				GGTGACTGAGTATTCCCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64481	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CACGTGGCTGCACGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64482	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CACGTGGCTGCACGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64483	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CACGTGGCTGCACGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64484	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CACGTGGCTGCACGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64485	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CACGTGGCTGCACGTAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64486	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TGGTCTTGCCGAATACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64487	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TGGTCTTGCCGAATACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64488	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TGGTCTTGCCGAATACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64489	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TGGTCTTGCCGAATACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64490	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TGGTCTTGCCGAATACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64491	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TCAGGCTCTCTAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64492	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TCAGGCTCTCTAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64493	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TCAGGCTCTCTAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64494	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TCAGGCTCTCTAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64495	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TCAGGCTCTCTAGCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64496	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TGGACACAGGGGTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64497	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TGGACACAGGGGTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64498	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TGGACACAGGGGTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64499	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TGGACACAGGGGTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64500	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TGGACACAGGGGTCATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64501	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CCTCATCAAATATTTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64502	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CCTCATCAAATATTTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64503	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CCTCATCAAATATTTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64504	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CCTCATCAAATATTTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64505	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CCTCATCAAATATTTGTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64506	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				TATGTTGAGCCACAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64507	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TATGTTGAGCCACAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64508	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				TATGTTGAGCCACAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64509	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				TATGTTGAGCCACAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64510	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				TATGTTGAGCCACAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64511	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				GTGTGGGCCTACTTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64512	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GTGTGGGCCTACTTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64513	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				GTGTGGGCCTACTTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64514	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GTGTGGGCCTACTTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64515	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				GTGTGGGCCTACTTTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64516	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CCTCCCCGTCTCTATAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64517	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CCTCCCCGTCTCTATAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64518	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CCTCCCCGTCTCTATAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64519	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CCTCCCCGTCTCTATAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64520	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CCTCCCCGTCTCTATAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64521	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				ACAGGGCTTAGACGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64522	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				ACAGGGCTTAGACGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64523	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				ACAGGGCTTAGACGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64524	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				ACAGGGCTTAGACGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64525	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				ACAGGGCTTAGACGGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64526	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CAAAAAACAACACCCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64527	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CAAAAAACAACACCCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64528	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CAAAAAACAACACCCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64529	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CAAAAAACAACACCCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64530	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CAAAAAACAACACCCCAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64531	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CTGGGTTTTATGGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64532	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CTGGGTTTTATGGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64533	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CTGGGTTTTATGGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64534	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CTGGGTTTTATGGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64535	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CTGGGTTTTATGGCAGGGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64536	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				GTCAAATAAAGCAGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64537	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GTCAAATAAAGCAGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64538	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				GTCAAATAAAGCAGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64539	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GTCAAATAAAGCAGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64540	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				GTCAAATAAAGCAGGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64541	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				CTGGATGCTCACAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64542	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CTGGATGCTCACAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64543	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				CTGGATGCTCACAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64544	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				CTGGATGCTCACAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64545	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				CTGGATGCTCACAGACCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64546	hg19	N/A	enh21337	N/A	Enhatls131857	enhancer	E_787				GATAGTTTCCACCAGATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	5045				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64547	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GATAGTTTCCACCAGATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	4202				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64548	hg19	N/A	enh21337	fant15052	N/A	enhancer	E_787				GATAGTTTCCACCAGATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	3859				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123224	chr4	6689591	6698402	6687864	6696675	64549	hg19	N/A	enh21337	N/A	N/A	enhancer	E_787				GATAGTTTCCACCAGATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	2476				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	768
enhrx-123225	chr4	6689591	6698402	6687864	6696675	64550	hg19	N/A	N/A	N/A	Enhatls131858	enhancer	E_787				GATAGTTTCCACCAGATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					S100P	chr4	6693877	6697170	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	769
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64551	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				TGTCCAAGGCCACATCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64552	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				TGAAACACCAGGCTAGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64553	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				GCAGAAAGCATTCTTCCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64554	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				AGATTCTAATTTCAGATCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64555	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				TGTCTGGCCAGGAGTAGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64556	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				TTAGGGCTAAACTTGGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64557	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				TGTGATCCAGAGCTCTAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64558	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				ACATTGGCACCACCTTTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64559	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				AGATGACGTGGACCAGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64560	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				AGTCACCGCTGGCTCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64561	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				AGATGGGATGCAGGTCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64562	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				GTCTGCCTGAAGCCGAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64563	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				AGATGCCCCAGAGGGACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123261	chr4	7631631	7633503	7629904	7631776	64564	hg19	N/A	enh36333	N/A	Enhatls131902	enhancer	E_789				CATCACCGAGTAGGTCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	805
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64565	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64566	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64567	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64568	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64569	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64570	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64571	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64572	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64573	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64574	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64575	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64576	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64577	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64578	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64579	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64580	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GCACACCTGCCTGTGCTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64581	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64582	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64583	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64584	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64585	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64586	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64587	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64588	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64589	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64590	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64591	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64592	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64593	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64594	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64595	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64596	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CCACTGCTGTTCACCAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64597	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64598	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64599	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64600	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64601	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64602	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64603	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64604	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64605	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64606	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64607	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64608	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64609	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64610	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64611	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64612	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				TGCCCGTGACAAGGACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64613	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64614	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64615	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64616	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64617	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64618	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64619	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64620	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64621	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64622	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64623	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64624	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64625	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64626	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64627	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64628	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CTAATAGCCGCCAGGATCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64629	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64630	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64631	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64632	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64633	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64634	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64635	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64636	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64637	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64638	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64639	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64640	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64641	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64642	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64643	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64644	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GCCAGTGACGGAAATTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64645	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64646	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64647	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64648	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64649	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64650	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64651	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64652	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64653	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64654	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64655	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64656	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64657	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64658	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64659	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64660	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				TCAAGTGCAGGTCTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64661	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64662	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64663	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64664	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64665	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64666	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64667	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64668	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64669	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64670	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64671	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64672	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64673	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64674	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64675	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64676	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GGTGCCCCCACAACATCGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64677	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64678	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64679	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64680	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64681	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64682	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64683	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64684	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64685	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64686	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64687	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64688	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64689	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64690	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64691	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64692	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CTATTACGGGTGTTATCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64693	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64694	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64695	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64696	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64697	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64698	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64699	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64700	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64701	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64702	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64703	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64704	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64705	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64706	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64707	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64708	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				AATCTGGCCTCCCGCTTTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64709	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64710	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64711	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64712	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64713	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64714	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64715	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64716	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64717	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64718	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64719	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64720	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64721	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64722	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64723	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64724	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				TAGGGTTCTTGGGCTCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64725	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64726	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64727	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64728	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64729	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64730	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64731	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64732	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64733	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64734	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64735	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64736	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64737	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64738	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64739	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64740	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CTGGGGCATCATTTTATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64741	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64742	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64743	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64744	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64745	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64746	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64747	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64748	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64749	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64750	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64751	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64752	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64753	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64754	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64755	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64756	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GACGCCAGCTCCGCAGACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64757	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64758	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64759	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64760	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64761	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64762	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64763	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64764	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64765	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64766	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64767	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64768	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64769	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64770	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64771	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64772	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CGCCTCACAGGTGCAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64773	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64774	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64775	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64776	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64777	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64778	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64779	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64780	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64781	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64782	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64783	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64784	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64785	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64786	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64787	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64788	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				TGAGTGAGTGAGTCTGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64789	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64790	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64791	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64792	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64793	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64794	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64795	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64796	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64797	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64798	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64799	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64800	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64801	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64802	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64803	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64804	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CATCCATCATCTGTGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64805	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64806	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64807	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64808	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64809	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64810	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64811	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64812	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64813	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64814	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64815	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64816	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64817	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64818	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64819	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64820	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GCATTGTTCCCTTCAGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	indirect	Non Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64821	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64822	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64823	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64824	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64825	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64826	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64827	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64828	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64829	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64830	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64831	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64832	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64833	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64834	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64835	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64836	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GGCCTGAGACCTCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64837	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64838	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64839	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64840	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64841	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64842	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64843	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64844	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64845	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64846	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64847	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64848	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64849	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64850	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64851	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64852	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				AAGGGAGAGCTCTTTAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64853	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64854	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64855	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64856	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64857	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64858	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64859	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64860	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64861	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64862	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64863	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64864	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64865	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64866	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64867	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64868	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				TGAAATCTCAATAGACTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64869	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64870	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64871	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64872	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64873	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64874	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64875	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64876	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64877	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64878	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64879	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64880	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64881	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64882	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64883	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64884	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				CATTTGCCTCACCTTCTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64885	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64886	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64887	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64888	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64889	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64890	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64891	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64892	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64893	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64894	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64895	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64896	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64897	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64898	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64899	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64900	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GAGGAAGGTTGGGAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64901	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64902	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64903	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64904	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64905	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64906	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64907	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64908	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64909	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64910	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64911	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64912	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64913	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64914	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64915	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64916	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GCAAGTGGTTGAGATGTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64917	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64918	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64919	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64920	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64921	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64922	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64923	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64924	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64925	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64926	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64927	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64928	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64929	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64930	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64931	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64932	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				ATCAGTGGCCACTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64933	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64934	hg19	N/A	enh36334	fant15083	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64935	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64936	hg19	N/A	enh36334	fant15084	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64937	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64938	hg19	N/A	enh36334	fant15085	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64939	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64940	hg19	N/A	enh36334	fant15086	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64941	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64942	hg19	N/A	enh36334	fant15087	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64943	hg19	N/A	enh36334	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123262	chr4	7647494	7663514	7645767	7661787	64944	hg19	N/A	N/A	N/A	Enhatls131903	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	806
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64945	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64946	hg19	N/A	N/A	fant15088	Enhatls131904	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123263	chr4	7647494	7663514	7645767	7661787	64947	hg19	N/A	N/A	N/A	Enhatls131904	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	807
enhrx-123264	chr4	7647494	7663514	7645767	7661787	64948	hg19	N/A	N/A	N/A	Enhatls131905	enhancer	E_790				GCAAACTGAGCCTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TADA2B	direct	Highly Significant	NA					SORCS2	chr4	7192537	7742836	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	808
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64949	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GCTTGAAAATATATCTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64950	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				CACAATTCAGCATTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64951	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GCTATAGCTGCTAGGACCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64952	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GGTCATTGAATTTTACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64953	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GCAAATTTTTATGGACTCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64954	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				TTAAATATTGTCAGAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64955	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GTTACAAAAAATCATAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64956	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				GATAAGGCTATGGAGAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64957	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				CTGCTCTTTCCACTTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64958	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				AAATGCAAGTGATATTTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-123975	chr4	30930634	30933106	30929012	30931484	64959	hg19	N/A	enh54644	N/A	Enhatls132671	enhancer	E_792				TCGTAGTCTGATCTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PCDH7	direct	Highly Significant	NA					PCDH7	chr4	30720368	31146805	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1519
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64960	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GTAAGTGAACAAAAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64961	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				GTAAGTGAACAAAAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64962	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GTAAGTGAACAAAAAACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64963	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TTCAGGGCGTGCATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64964	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TTCAGGGCGTGCATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64965	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TTCAGGGCGTGCATGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64966	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCGCCTAGTCCGTCACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64967	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TCGCCTAGTCCGTCACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64968	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCGCCTAGTCCGTCACCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64969	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCAGGGAGGAGGATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64970	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TCCAGGGAGGAGGATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64971	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCAGGGAGGAGGATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64972	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCTGAAGCACGGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64973	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TCTGAAGCACGGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64974	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCTGAAGCACGGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64975	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TGGCGGGAGGCGTAATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64976	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TGGCGGGAGGCGTAATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64977	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TGGCGGGAGGCGTAATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64978	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				CCTTGGGATAGATTCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64979	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				CCTTGGGATAGATTCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64980	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				CCTTGGGATAGATTCTGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64981	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				ACTCGGCGTGAACCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64982	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				ACTCGGCGTGAACCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64983	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				ACTCGGCGTGAACCGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64984	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GGGCGCCCGGAGCGACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64985	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				GGGCGCCCGGAGCGACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64986	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GGGCGCCCGGAGCGACAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64987	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TAAGCATTCAAATCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64988	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TAAGCATTCAAATCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64989	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TAAGCATTCAAATCAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64990	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GGTTGCTTACTCTTACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64991	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				GGTTGCTTACTCTTACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64992	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GGTTGCTTACTCTTACACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64993	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				CGCCAATCTCATGAAATAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64994	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				CGCCAATCTCATGAAATAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64995	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				CGCCAATCTCATGAAATAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64996	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCCAAATCCCCAACACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64997	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TCCCAAATCCCCAACACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64998	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCCAAATCCCCAACACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	64999	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TGCGTGATGCAGGCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65000	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TGCGTGATGCAGGCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65001	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TGCGTGATGCAGGCTCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65002	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GTTGGGATTTAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65003	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				GTTGGGATTTAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65004	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				GTTGGGATTTAGGGAAGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65005	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCTCCAGGATTTCAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65006	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				TCCTCCAGGATTTCAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65007	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				TCCTCCAGGATTTCAAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65008	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				ATTTCTTCTGCATTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65009	hg19	N/A	N/A	fant16241	Enhatls135112	enhancer	E_793				ATTTCTTCTGCATTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-126297	chr4	84029867	84032499	83108714	83111346	65010	hg19	N/A	N/A	N/A	Enhatls135112	enhancer	E_793				ATTTCTTCTGCATTTCATCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	COQ2	direct	Highly Significant	NA					PLAC8	chr4	83090047	83137075	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3841
enhrx-130253	chr5	307630	317852	307515	317737	65011	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65012	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65013	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65014	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65015	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65016	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				AGGATATGCCACAGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65017	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65018	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65019	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65020	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65021	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65022	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				GTGTGTTCGGGCACCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65023	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65024	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65025	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65026	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65027	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65028	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				CCCTGTGGGAGGCCTTTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65029	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65030	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65031	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65032	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65033	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65034	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				CAGTGACTTGGACCTTTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65035	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65036	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65037	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65038	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65039	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65040	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				TCTGAATGATTCGCTGCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65041	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65042	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65043	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65044	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65045	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65046	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				ACTTTGAAAGTAACTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65047	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65048	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65049	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65050	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65051	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65052	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				GTTTGGTGAGTGCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65053	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65054	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65055	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65056	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65057	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65058	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				TCCGGGGTCATGGTCTCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65059	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65060	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65061	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65062	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65063	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65064	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				CCTCTAACACACACAATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65065	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65066	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65067	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65068	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65069	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65070	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				AGAGCCGGTAGCCTTCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65071	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65072	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65073	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65074	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65075	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65076	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				GCCTTCGACGACTTCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130253	chr5	307630	317852	307515	317737	65077	hg19	N/A	enh37523	N/A	Enhatls139232	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130253	chr5	307630	317852	307515	317737	65078	hg19	N/A	N/A	N/A	Enhatls139232	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	44
enhrx-130254	chr5	307630	317852	307515	317737	65079	hg19	N/A	N/A	N/A	Enhatls139233	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65080	hg19	N/A	enh37524	N/A	Enhatls139233	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65081	hg19	N/A	enh37524	N/A	N/A	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	307630	317852	307515	317737	65082	hg19	N/A	enh37524	N/A	Enhatls139234	enhancer	E_794				GTGACGGAATGGCTTCACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					PDCD6	chr5	271620	314974	2				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130254	chr5	342600	344498	342485	344383	65083	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				CACCCCCGAGAAGGTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65084	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				CACCCCCGAGAAGGTATGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65085	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GCCTCCAAACACTCGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65086	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GCCTCCAAACACTCGTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65087	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				TCGAGGAAGCCAGGAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65088	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				TCGAGGAAGCCAGGAACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65089	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GTCACGCCTGGGCCTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65090	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GTCACGCCTGGGCCTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65091	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GGACCGCGCTGAGGGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65092	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GGACCGCGCTGAGGGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65093	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GCGTACGTGCACTCCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65094	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GCGTACGTGCACTCCCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65095	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GGGTTGTTGCACCCATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65096	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GGGTTGTTGCACCCATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65097	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				GCCGGGGCTGAGCTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65098	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				GCCGGGGCTGAGCTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65099	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				CGCAGGGACGAGCCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65100	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				CGCAGGGACGAGCCTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65101	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				TGAGCGGTGGAGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65102	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				TGAGCGGTGGAGCGAGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65103	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				CAGGCGAGACCGCCACCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65104	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				CAGGCGAGACCGCCACCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130254	chr5	342600	344498	342485	344383	65105	hg19	N/A	N/A	N/A	Enhatls139234	enhancer	E_795				TCTGCGGGTGGGGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	45
enhrx-130255	chr5	342600	344498	342485	344383	65106	hg19	N/A	N/A	N/A	Enhatls139235	enhancer	E_795				TCTGCGGGTGGGGAGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	46
enhrx-130256	chr5	368063	380289	367948	380174	65107	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65108	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65109	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65110	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65111	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65112	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65113	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65114	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65115	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65116	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65117	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65118	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65119	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65120	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65121	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65122	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCTTCGTTTCTGGGCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65123	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65124	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65125	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65126	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65127	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65128	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65129	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65130	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65131	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65132	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65133	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65134	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65135	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65136	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65137	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65138	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CTGGTGGAGGAGGAGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65139	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65140	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65141	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65142	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65143	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65144	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65145	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65146	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65147	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65148	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65149	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65150	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65151	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65152	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65153	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65154	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AAGGTGTCACCGGGAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65155	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65156	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65157	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65158	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65159	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65160	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65161	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65162	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65163	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65164	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65165	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65166	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65167	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65168	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65169	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65170	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGCCCTTAGCAGGACCCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65171	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65172	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65173	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65174	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65175	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65176	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65177	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65178	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65179	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65180	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65181	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65182	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65183	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65184	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65185	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65186	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GAAGTCAGCACCAAGGCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65187	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65188	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65189	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65190	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65191	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65192	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65193	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65194	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65195	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65196	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65197	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65198	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65199	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65200	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65201	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65202	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACTCTGCAGCCGTGGGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65203	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65204	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65205	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65206	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65207	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65208	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65209	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65210	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65211	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65212	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65213	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65214	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65215	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65216	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65217	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65218	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TCCGGGTTCAGGCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65219	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65220	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65221	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65222	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65223	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65224	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65225	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65226	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65227	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65228	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65229	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65230	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65231	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65232	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65233	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65234	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GATGAGACCCAGCCGGGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65235	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65236	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65237	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65238	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65239	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65240	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65241	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65242	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65243	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65244	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65245	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65246	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65247	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65248	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65249	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65250	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				TGCGGGACCAGCAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65251	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65252	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65253	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65254	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65255	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65256	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65257	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65258	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65259	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65260	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65261	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65262	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65263	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65264	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65265	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65266	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTGTGCCTTGTAAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65267	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65268	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65269	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65270	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65271	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65272	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65273	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65274	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65275	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65276	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65277	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65278	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65279	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65280	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65281	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65282	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				CAACTGCGGTGGCTGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65283	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65284	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65285	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65286	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65287	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65288	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65289	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65290	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65291	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65292	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65293	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65294	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65295	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65296	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65297	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65298	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGCCTGGGGGTCCCACCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65299	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65300	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65301	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65302	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65303	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65304	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65305	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65306	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65307	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65308	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65309	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65310	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65311	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65312	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65313	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65314	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GGGGAGCGCCAGGCGCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65315	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65316	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65317	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65318	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65319	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65320	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65321	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65322	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65323	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65324	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65325	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65326	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65327	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65328	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65329	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65330	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				AGTGGGCGGGCGCCCGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65331	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65332	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65333	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65334	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65335	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65336	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65337	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65338	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65339	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65340	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65341	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65342	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65343	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65344	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65345	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65346	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCTTCTCGGGGAAAAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65347	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65348	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65349	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65350	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65351	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65352	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65353	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65354	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65355	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65356	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65357	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65358	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65359	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65360	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65361	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65362	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				ACACAGACCGACCACCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130256	chr5	368063	380289	367948	380174	65363	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65364	hg19	N/A	enh37525	fant17709	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65365	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65366	hg19	N/A	enh37525	fant17710	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65367	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65368	hg19	N/A	enh37525	fant17711	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65369	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65370	hg19	N/A	enh37525	fant17712	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65371	hg19	N/A	enh37525	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130256	chr5	368063	380289	367948	380174	65372	hg19	N/A	N/A	N/A	Enhatls139236	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	47
enhrx-130257	chr5	368063	380289	367948	380174	65373	hg19	N/A	enh37526	N/A	N/A	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65374	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65375	hg19	N/A	enh37526	fant17713	Enhatls139237	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65376	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65377	hg19	N/A	enh37526	fant17714	Enhatls139237	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	368063	380289	367948	380174	65378	hg19	N/A	enh37526	N/A	Enhatls139237	enhancer	E_796				GCCAGCACGGGGGTCTCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65379	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGTGGAGCCGCAGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65380	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GTGTGGAGCCGCAGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65381	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGTGGAGCCGCAGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65382	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GTGTGGAGCCGCAGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65383	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGTGGAGCCGCAGGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65384	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCAGGACACACCCAGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65385	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GCAGGACACACCCAGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65386	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCAGGACACACCCAGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65387	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GCAGGACACACCCAGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65388	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCAGGACACACCCAGGGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65389	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCATCCTGCCGGGGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65390	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				CCATCCTGCCGGGGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65391	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCATCCTGCCGGGGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65392	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				CCATCCTGCCGGGGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65393	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCATCCTGCCGGGGTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65394	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GACTTACAACTCATAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65395	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GACTTACAACTCATAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65396	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GACTTACAACTCATAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65397	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GACTTACAACTCATAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65398	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GACTTACAACTCATAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65399	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GGGTGTTTGCACTCAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65400	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GGGTGTTTGCACTCAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65401	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GGGTGTTTGCACTCAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65402	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GGGTGTTTGCACTCAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65403	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GGGTGTTTGCACTCAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65404	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCCTCCAGTCACAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65405	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				CCCTCCAGTCACAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65406	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCCTCCAGTCACAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65407	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				CCCTCCAGTCACAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65408	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCCTCCAGTCACAGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65409	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGAGCGTCTGTGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65410	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GTGAGCGTCTGTGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65411	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGAGCGTCTGTGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65412	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GTGAGCGTCTGTGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65413	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GTGAGCGTCTGTGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65414	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCTGGTCTCTCAGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65415	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				GCTGGTCTCTCAGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65416	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCTGGTCTCTCAGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65417	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				GCTGGTCTCTCAGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65418	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				GCTGGTCTCTCAGCCAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65419	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCTGCTCTTCTAGGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65420	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				CCTGCTCTTCTAGGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65421	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCTGCTCTTCTAGGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65422	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				CCTGCTCTTCTAGGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65423	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CCTGCTCTTCTAGGGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65424	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CAAATGTCGGAGCTGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65425	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				CAAATGTCGGAGCTGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65426	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CAAATGTCGGAGCTGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65427	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				CAAATGTCGGAGCTGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65428	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				CAAATGTCGGAGCTGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65429	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				TGGAGGCAGATCACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65430	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				TGGAGGCAGATCACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65431	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				TGGAGGCAGATCACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65432	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				TGGAGGCAGATCACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65433	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				TGGAGGCAGATCACTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65434	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGTTACGGAGCCACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65435	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				ACGGTTACGGAGCCACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65436	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGTTACGGAGCCACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65437	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				ACGGTTACGGAGCCACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65438	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGTTACGGAGCCACAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65439	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACAACCCTCCACATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65440	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				AACAACCCTCCACATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65441	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACAACCCTCCACATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65442	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				AACAACCCTCCACATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65443	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACAACCCTCCACATCCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65444	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ATAATCTTTGAAGTACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65445	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				ATAATCTTTGAAGTACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65446	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ATAATCTTTGAAGTACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65447	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				ATAATCTTTGAAGTACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65448	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ATAATCTTTGAAGTACTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65449	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACGTTTGCCCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65450	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				AACGTTTGCCCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65451	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACGTTTGCCCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65452	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				AACGTTTGCCCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65453	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				AACGTTTGCCCCATTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65454	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGAGGTCGGGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65455	hg19	N/A	enh22020	fant17719	Enhatls139237	enhancer	E_797				ACGGAGGTCGGGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65456	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGAGGTCGGGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65457	hg19	N/A	enh22020	fant17720	Enhatls139237	enhancer	E_797				ACGGAGGTCGGGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130257	chr5	398405	402446	398290	402331	65458	hg19	N/A	enh22020	N/A	Enhatls139237	enhancer	E_797				ACGGAGGTCGGGGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	48
enhrx-130258	chr5	422928	425528	422813	425413	65459	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				TGTCTCTGGTGGGTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65460	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				TGTCTCTGGTGGGTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65461	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				TGTCTCTGGTGGGTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65462	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				TGTCTCTGGTGGGTGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65463	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GACTCATCACGCATGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65464	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GACTCATCACGCATGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65465	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GACTCATCACGCATGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65466	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GACTCATCACGCATGCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65467	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GTTTTACATTCTCATCGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65468	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTTTTACATTCTCATCGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65469	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GTTTTACATTCTCATCGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65470	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTTTTACATTCTCATCGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65471	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				ATGTGCCCCACATCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65472	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				ATGTGCCCCACATCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65473	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				ATGTGCCCCACATCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65474	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				ATGTGCCCCACATCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65475	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GTATCTGTTTGCAAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65476	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTATCTGTTTGCAAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65477	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GTATCTGTTTGCAAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65478	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTATCTGTTTGCAAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65479	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				CTTTGCCCTGACATGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65480	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				CTTTGCCCTGACATGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65481	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				CTTTGCCCTGACATGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65482	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				CTTTGCCCTGACATGTCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65483	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GGCTGACTGTGCTGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65484	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GGCTGACTGTGCTGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65485	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GGCTGACTGTGCTGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65486	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GGCTGACTGTGCTGTGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65487	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GCTACAGTGCTGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65488	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GCTACAGTGCTGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65489	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GCTACAGTGCTGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65490	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GCTACAGTGCTGGAGTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130258	chr5	422928	425528	422813	425413	65491	hg19	N/A	N/A	N/A	Enhatls139239	enhancer	E_798				GTCATGGGTCCACAAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	49
enhrx-130259	chr5	422928	425528	422813	425413	65492	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTCATGGGTCCACAAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65493	hg19	N/A	N/A	fant17725	Enhatls139240	enhancer	E_798				GTCATGGGTCCACAAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	422928	425528	422813	425413	65494	hg19	N/A	N/A	N/A	Enhatls139240	enhancer	E_798				GTCATGGGTCCACAAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65495	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				ACAGTGTTCCAGGGTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65496	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				ACAGTGTTCCAGGGTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65497	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				ACAGTGTTCCAGGGTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65498	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				ACAGTGTTCCAGGGTTTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65499	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				ACCGGGCTTGCCATGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65500	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				ACCGGGCTTGCCATGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65501	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				ACCGGGCTTGCCATGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65502	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				ACCGGGCTTGCCATGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65503	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				AGCCCCCTGGTGTCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65504	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				AGCCCCCTGGTGTCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65505	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				AGCCCCCTGGTGTCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65506	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				AGCCCCCTGGTGTCAGAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65507	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				CACACCTACGCTCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65508	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				CACACCTACGCTCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65509	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				CACACCTACGCTCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65510	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				CACACCTACGCTCCACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65511	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				CCTGGACGAGACCCCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65512	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				CCTGGACGAGACCCCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65513	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				CCTGGACGAGACCCCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65514	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				CCTGGACGAGACCCCCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65515	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				ACAAGGTGTATCCTGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65516	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				ACAAGGTGTATCCTGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65517	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				ACAAGGTGTATCCTGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65518	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				ACAAGGTGTATCCTGAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65519	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				AGGCTGCTGCCACTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65520	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				AGGCTGCTGCCACTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65521	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				AGGCTGCTGCCACTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65522	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				AGGCTGCTGCCACTGCCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65523	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				AAAAGCTGTGGAAGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65524	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				AAAAGCTGTGGAAGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65525	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				AAAAGCTGTGGAAGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65526	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				AAAAGCTGTGGAAGACTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65527	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				CAGTGAATTATGGCGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65528	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				CAGTGAATTATGGCGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65529	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				CAGTGAATTATGGCGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65530	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				CAGTGAATTATGGCGAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65531	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				GTTAGTCATGGGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65532	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				GTTAGTCATGGGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65533	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				GTTAGTCATGGGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65534	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				GTTAGTCATGGGCCTCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65535	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				AGTAGCGCTGCCCCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65536	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				AGTAGCGCTGCCCCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65537	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				AGTAGCGCTGCCCCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65538	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				AGTAGCGCTGCCCCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65539	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				AATCTACCAGGGTGAGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65540	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				AATCTACCAGGGTGAGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65541	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				AATCTACCAGGGTGAGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65542	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				AATCTACCAGGGTGAGTTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-130259	chr5	429949	435300	429834	435185	65543	hg19	N/A	enh45805	N/A	Enhatls139242	enhancer	E_799				GATCAGTGTGATGCGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130259	chr5	429949	435300	429834	435185	65544	hg19	N/A	N/A	N/A	Enhatls139242	enhancer	E_799				GATCAGTGTGATGCGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	50
enhrx-130260	chr5	429949	435300	429834	435185	65545	hg19	N/A	N/A	N/A	Enhatls139243	enhancer	E_799				GATCAGTGTGATGCGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	51
enhrx-130261	chr5	429949	435300	429834	435185	65546	hg19	N/A	N/A	N/A	Enhatls139244	enhancer	E_799				GATCAGTGTGATGCGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	indirect	Non Significant	NA					AHRR	chr5	321713	438291	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	52
enhrx-lit823	chr5	441776	444724	441661	444609	65547	hg19					enhancer	E_800				AGACAAACCCTGAACGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit824	chr5	441776	444724	441661	444609	65548	hg19					enhancer	E_800				AGGACCGGCCCTCTGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit825	chr5	441776	444724	441661	444609	65549	hg19					enhancer	E_800				GGGGCCCCGGAAACATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit826	chr5	441776	444724	441661	444609	65550	hg19					enhancer	E_800				ACCTGCCACCAGCAGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit827	chr5	441776	444724	441661	444609	65551	hg19					enhancer	E_800				CCGGCGCCCACCTCAGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit828	chr5	441776	444724	441661	444609	65552	hg19					enhancer	E_800				ATGCACGCAGTCACGCTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit829	chr5	441776	444724	441661	444609	65553	hg19					enhancer	E_800				GCGCACGCGGTGGTCGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit830	chr5	441776	444724	441661	444609	65554	hg19					enhancer	E_800				GCAGGACAGGGAAACCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit831	chr5	441776	444724	441661	444609	65555	hg19					enhancer	E_800				GGAGACGAGTACCCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit832	chr5	441776	444724	441661	444609	65556	hg19					enhancer	E_800				GCCGGAAGTGGACAGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit833	chr5	441776	444724	441661	444609	65557	hg19					enhancer	E_800				GAGTCGGTGGCAGGTCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit834	chr5	441776	444724	441661	444609	65558	hg19					enhancer	E_800				CCTGTCTCTGGCTTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit835	chr5	441776	444724	441661	444609	65559	hg19					enhancer	E_800				GGAGGCCGTTCCGGACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit836	chr5	441776	444724	441661	444609	65560	hg19					enhancer	E_800				CAAGGGGACACCTACGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit837	chr5	441776	444724	441661	444609	65561	hg19					enhancer	E_800				GTGGGGGAAGACACTGTTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-130329	chr5	910591	913584	910476	913469	65562	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				TGAGCTGATAGTTGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65563	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				TGAGCTGATAGTTGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65564	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TGAGCTGATAGTTGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65565	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				TGAGCTGATAGTTGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65566	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TGAGCTGATAGTTGAAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65567	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				TTTGAGGTACCAGTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65568	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				TTTGAGGTACCAGTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65569	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TTTGAGGTACCAGTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65570	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				TTTGAGGTACCAGTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65571	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TTTGAGGTACCAGTCAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65572	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				CCGGGGTAAGCTGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65573	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				CCGGGGTAAGCTGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65574	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CCGGGGTAAGCTGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65575	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				CCGGGGTAAGCTGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65576	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CCGGGGTAAGCTGAGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65577	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				TAAGGATACAGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65578	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				TAAGGATACAGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65579	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TAAGGATACAGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65580	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				TAAGGATACAGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65581	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TAAGGATACAGGCCCCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65582	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				GCGTAGTATGGGCCTGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65583	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				GCGTAGTATGGGCCTGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65584	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GCGTAGTATGGGCCTGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65585	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				GCGTAGTATGGGCCTGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65586	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GCGTAGTATGGGCCTGGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65587	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				GGCAGGAACACTGTTGCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65588	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				GGCAGGAACACTGTTGCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65589	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GGCAGGAACACTGTTGCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65590	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				GGCAGGAACACTGTTGCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65591	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GGCAGGAACACTGTTGCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65592	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				GGAGCGTGTGTGAGTCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65593	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				GGAGCGTGTGTGAGTCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65594	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GGAGCGTGTGTGAGTCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65595	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				GGAGCGTGTGTGAGTCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65596	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				GGAGCGTGTGTGAGTCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65597	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				ACGTGCGGTGAGTGTGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65598	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				ACGTGCGGTGAGTGTGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65599	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				ACGTGCGGTGAGTGTGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65600	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				ACGTGCGGTGAGTGTGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65601	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				ACGTGCGGTGAGTGTGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65602	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				AGCGTCACTGCCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65603	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				AGCGTCACTGCCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65604	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				AGCGTCACTGCCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65605	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				AGCGTCACTGCCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65606	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				AGCGTCACTGCCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65607	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				CTTTGTTTAGGGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65608	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				CTTTGTTTAGGGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65609	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CTTTGTTTAGGGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65610	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				CTTTGTTTAGGGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65611	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CTTTGTTTAGGGTAGTTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65612	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				CTGCTGGTACCACAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65613	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				CTGCTGGTACCACAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65614	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CTGCTGGTACCACAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65615	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				CTGCTGGTACCACAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65616	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				CTGCTGGTACCACAGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130329	chr5	910591	913584	910476	913469	65617	hg19	N/A	enh63382	N/A	Enhatls139314	enhancer	E_801				TCCAGGCATGGTTTTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130329	chr5	910591	913584	910476	913469	65618	hg19	N/A	N/A	N/A	Enhatls139314	enhancer	E_801				TCCAGGCATGGTTTTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	120
enhrx-130330	chr5	910591	913584	910476	913469	65619	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TCCAGGCATGGTTTTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65620	hg19	N/A	N/A	fant17744	Enhatls139315	enhancer	E_801				TCCAGGCATGGTTTTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130330	chr5	910591	913584	910476	913469	65621	hg19	N/A	N/A	N/A	Enhatls139315	enhancer	E_801				TCCAGGCATGGTTTTCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					TRIP13	chr5	892883	918120	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	121
enhrx-130333	chr5	979830	981840	979715	981725	65622	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				AGTTCCTGCTGTAAATGATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65623	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				GCCCACTGTATACCAGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65624	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				GAGTGAATGGTCACTGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65625	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				CACACCACAATCCCTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65626	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				CAGAGAAGCCAACTCTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65627	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				GTTGCACTGCCAGGGACGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65628	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				ACACAGACACAACATGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65629	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				TCTTCCCGCCGGAGAAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65630	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				AAGAGGCTGGGAGGCGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65631	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				GCCAGAGACCGCTAAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130333	chr5	979830	981840	979715	981725	65632	hg19	N/A	enh48907	N/A	Enhatls139318	enhancer	E_802				AGTAGCCAGTCACAAAACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					NKD2	chr5	1008801	1038943	23908				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	124
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65633	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GCCCTTCTGGGCCGTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65634	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCCCTTCTGGGCCGTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65635	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GCCCTTCTGGGCCGTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65636	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCCCTTCTGGGCCGTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65637	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GCCCTTCTGGGCCGTGCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65638	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TGTCCTGCACCCCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65639	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGTCCTGCACCCCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65640	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TGTCCTGCACCCCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65641	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGTCCTGCACCCCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65642	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TGTCCTGCACCCCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65643	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TTGAGCCCGTCCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65644	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TTGAGCCCGTCCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65645	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TTGAGCCCGTCCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65646	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TTGAGCCCGTCCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65647	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TTGAGCCCGTCCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65648	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TGACTTCCAGGACCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65649	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGACTTCCAGGACCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65650	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TGACTTCCAGGACCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65651	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGACTTCCAGGACCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65652	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TGACTTCCAGGACCAGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65653	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GGGCCCAGCCCACAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65654	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GGGCCCAGCCCACAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65655	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GGGCCCAGCCCACAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65656	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GGGCCCAGCCCACAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65657	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GGGCCCAGCCCACAGAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65658	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GCTTTGTAACTCCAGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65659	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCTTTGTAACTCCAGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65660	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GCTTTGTAACTCCAGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65661	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCTTTGTAACTCCAGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65662	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GCTTTGTAACTCCAGCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65663	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TCGTGGACCAACAGACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65664	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TCGTGGACCAACAGACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65665	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TCGTGGACCAACAGACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65666	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TCGTGGACCAACAGACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65667	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TCGTGGACCAACAGACCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65668	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TTCCTGGAGACAAAGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65669	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TTCCTGGAGACAAAGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65670	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TTCCTGGAGACAAAGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65671	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TTCCTGGAGACAAAGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65672	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TTCCTGGAGACAAAGGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65673	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GTCTGGGATCACCCTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65674	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GTCTGGGATCACCCTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65675	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GTCTGGGATCACCCTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65676	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GTCTGGGATCACCCTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65677	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GTCTGGGATCACCCTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65678	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				TGACCTCCGTGGACGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65679	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGACCTCCGTGGACGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65680	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				TGACCTCCGTGGACGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65681	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				TGACCTCCGTGGACGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65682	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				TGACCTCCGTGGACGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65683	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GTGTTGCTGGCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65684	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GTGTTGCTGGCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65685	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GTGTTGCTGGCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65686	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GTGTTGCTGGCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65687	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GTGTTGCTGGCCCCCAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65688	hg19	N/A	N/A	fant17778	Enhatls139353	enhancer	E_803				GCTGGGGCGCCCTCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC12A7	chr5	1050383	1112063	44106				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65689	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCTGGGGCGCCCTCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	42345				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65690	hg19	N/A	enh63383	N/A	Enhatls139353	enhancer	E_803				GCTGGGGCGCCCTCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36815				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65691	hg19	N/A	N/A	N/A	Enhatls139353	enhancer	E_803				GCTGGGGCGCCCTCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	36125				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130372	chr5	1156569	1165995	1156454	1165880	65692	hg19	N/A	enh55150	N/A	Enhatls139353	enhancer	E_803				GCTGGGGCGCCCTCACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					SLC6A19	chr5	1201594	1225111	28500				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	163
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65693	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				GCCGTGTGTGCAGAGATTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65694	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				GTGCAGCTGTGTGTGAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65695	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				TGAATGTCCTAGAATAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65696	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				GCAATGACTCAACTCTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65697	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				CAGGATGCATAAATGAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65698	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				CGTGGTAATGAGGCAGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-130451	chr5	1788853	1795725	1788739	1795611	65699	hg19	N/A	enh8371	N/A	Enhatls139455	enhancer	E_804				TTAAAGACATGCTCAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TERT	direct	Highly Significant	NA					MRPL36	chr5	1798384	1801366	2009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	242
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65700	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TTTGCATTACCCATTAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65701	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				TTTGCATTACCCATTAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65702	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TTTGCATTACCCATTAAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65703	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCTCAGCCCGAGATTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65704	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				GCTCAGCCCGAGATTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65705	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCTCAGCCCGAGATTCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65706	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TTTCAGATGCAGAGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65707	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				TTTCAGATGCAGAGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65708	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TTTCAGATGCAGAGGACGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65709	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				AGGTAATTCCCCTCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65710	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				AGGTAATTCCCCTCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65711	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				AGGTAATTCCCCTCGGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65712	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				CAGGAGCCTGGCGTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65713	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				CAGGAGCCTGGCGTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65714	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				CAGGAGCCTGGCGTGCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65715	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GAAGCAAGTCGTCTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65716	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				GAAGCAAGTCGTCTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65717	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GAAGCAAGTCGTCTATGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65718	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCTGGTTTCAAGCTCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65719	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				GCTGGTTTCAAGCTCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65720	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCTGGTTTCAAGCTCAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65721	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				AGTCAGCTACCTCCTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65722	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				AGTCAGCTACCTCCTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65723	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				AGTCAGCTACCTCCTCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65724	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				ATAGCAAACATGTACGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65725	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				ATAGCAAACATGTACGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65726	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				ATAGCAAACATGTACGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65727	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCCAAAGGGTGGCCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65728	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				GCCAAAGGGTGGCCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65729	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				GCCAAAGGGTGGCCAGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65730	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TGGAAAAGGGTGTGCTCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	121671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65731	hg19	N/A	enh22317	fant18820	Enhatls141794	enhancer	E_805				TGGAAAAGGGTGTGCTCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	133938				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-132682	chr5	67729558	67731755	68433731	68435928	65732	hg19	N/A	enh22317	N/A	Enhatls141794	enhancer	E_805				TGGAAAAGGGTGTGCTCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	PIK3R1	direct	Highly Significant	NA					PIK3R1	chr5	68215740	68301821	134065				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2473
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65733	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65734	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65735	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65736	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65737	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65738	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65739	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65740	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGGTGCGTCAGGTTATGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65741	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65742	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65743	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65744	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65745	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65746	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65747	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65748	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				ATAAATATGTACTCCCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65749	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65750	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65751	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65752	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65753	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65754	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65755	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65756	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGAGGGAATGAGTCATCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65757	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65758	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65759	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65760	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65761	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65762	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65763	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65764	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GAGAAGAAACCAAAACCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65765	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65766	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65767	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65768	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65769	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65770	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65771	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65772	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCCCTGTAAGGAATGCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65773	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65774	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65775	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65776	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65777	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65778	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65779	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65780	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AAGAGAGCTGAACTTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65781	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65782	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65783	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65784	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65785	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65786	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65787	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65788	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				AGAGGAAAGGGCTTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65789	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65790	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65791	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65792	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65793	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65794	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65795	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65796	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				GCTTATTTATTACTCTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65797	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127561				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65798	hg19	N/A	enh38568	N/A	Enhatls146602	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	127941				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65799	hg19	N/A	enh38568	N/A	N/A	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128671				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65800	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	128791				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65801	hg19	N/A	enh38568	fant20580	Enhatls146603	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65802	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129286				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65803	hg19	N/A	enh38568	fant20581	Enhatls146603	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129441				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-137185	chr5	158885623	158890279	159458615	159463271	65804	hg19	N/A	enh38568	N/A	Enhatls146603	enhancer	E_809				TGGTGTACATACTGTAGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EBF1	direct	Highly Significant	NA					IL12B	chr5	159314779	159330862	129668				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6976
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65805	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GCTGTGCTGCTCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65806	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GCTGTGCTGCTCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65807	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GCTGTGCTGCTCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65808	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GCTGTGCTGCTCGCGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65809	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GGCTGGGGCGGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65810	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GGCTGGGGCGGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65811	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GGCTGGGGCGGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65812	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GGCTGGGGCGGGGCGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65813	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GGTGAGTTAGAACTAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65814	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GGTGAGTTAGAACTAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65815	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GGTGAGTTAGAACTAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65816	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GGTGAGTTAGAACTAGGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65817	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				TCGAAACAAACTGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65818	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				TCGAAACAAACTGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65819	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				TCGAAACAAACTGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65820	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				TCGAAACAAACTGCAAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65821	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				AGGAGGTGTTGGAGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65822	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				AGGAGGTGTTGGAGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65823	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				AGGAGGTGTTGGAGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65824	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				AGGAGGTGTTGGAGTCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65825	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				TGTCGGCGCCCCGAACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65826	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				TGTCGGCGCCCCGAACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65827	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				TGTCGGCGCCCCGAACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65828	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				TGTCGGCGCCCCGAACCGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65829	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CGGCCTGCAGGCCTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65830	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CGGCCTGCAGGCCTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65831	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CGGCCTGCAGGCCTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65832	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CGGCCTGCAGGCCTCAGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65833	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GCAGCTCGCCAAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65834	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GCAGCTCGCCAAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65835	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GCAGCTCGCCAAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65836	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GCAGCTCGCCAAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65837	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				TTGCAGTTCAGCGACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65838	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				TTGCAGTTCAGCGACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65839	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				TTGCAGTTCAGCGACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65840	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				TTGCAGTTCAGCGACCACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65841	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GCGCCTGCGCAACCTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65842	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GCGCCTGCGCAACCTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65843	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GCGCCTGCGCAACCTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65844	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GCGCCTGCGCAACCTAAATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65845	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CTCTTTGTGACGCAACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65846	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CTCTTTGTGACGCAACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65847	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CTCTTTGTGACGCAACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65848	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CTCTTTGTGACGCAACGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65849	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CCAAGCGTGTAATAATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65850	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CCAAGCGTGTAATAATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65851	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CCAAGCGTGTAATAATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65852	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CCAAGCGTGTAATAATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65853	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				AGGCGCAACAAAAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65854	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				AGGCGCAACAAAAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65855	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				AGGCGCAACAAAAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65856	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				AGGCGCAACAAAAAGCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65857	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				ACAGTCCCATAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65858	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				ACAGTCCCATAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65859	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				ACAGTCCCATAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65860	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				ACAGTCCCATAGGGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65861	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CCTGGCCGACCTGAAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65862	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CCTGGCCGACCTGAAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65863	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CCTGGCCGACCTGAAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65864	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CCTGGCCGACCTGAAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65865	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				TGCAGCTGACCAGCTTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65866	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				TGCAGCTGACCAGCTTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65867	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				TGCAGCTGACCAGCTTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65868	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				TGCAGCTGACCAGCTTCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65869	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GACGTGCCCCAGGCACCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65870	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GACGTGCCCCAGGCACCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65871	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GACGTGCCCCAGGCACCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65872	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GACGTGCCCCAGGCACCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65873	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CTAGGGCCCCGGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65874	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CTAGGGCCCCGGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65875	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CTAGGGCCCCGGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65876	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CTAGGGCCCCGGTCGGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65877	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GGCGGGTCAAGGGGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65878	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GGCGGGTCAAGGGGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65879	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GGCGGGTCAAGGGGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65880	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GGCGGGTCAAGGGGTACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65881	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CGGTAACCTACCGAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65882	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CGGTAACCTACCGAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65883	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CGGTAACCTACCGAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65884	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CGGTAACCTACCGAGCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65885	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CGTAGACGCTGCATTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65886	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CGTAGACGCTGCATTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65887	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CGTAGACGCTGCATTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65888	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CGTAGACGCTGCATTCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65889	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				CTGGGAGGCTACGGCATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65890	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				CTGGGAGGCTACGGCATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65891	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				CTGGGAGGCTACGGCATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65892	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				CTGGGAGGCTACGGCATCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138192	chr5	179047997	179052206	179620996	179625205	65893	hg19	N/A	N/A	N/A	Enhatls147737	enhancer	E_810				GTCTGTGTCCACTAAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7983
enhrx-138193	chr5	179047997	179052206	179620996	179625205	65894	hg19	N/A	N/A	N/A	Enhatls147738	enhancer	E_810				GTCTGTGTCCACTAAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7984
enhrx-138194	chr5	179047997	179052206	179620996	179625205	65895	hg19	N/A	N/A	N/A	Enhatls147739	enhancer	E_810				GTCTGTGTCCACTAAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7985
enhrx-138195	chr5	179047997	179052206	179620996	179625205	65896	hg19	N/A	N/A	N/A	Enhatls147740	enhancer	E_810				GTCTGTGTCCACTAAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					HNRNPH1	chr5	179614177	179634784	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7986
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65897	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65898	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65899	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65900	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65901	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65902	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65903	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65904	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65905	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65906	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65907	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GCTGAGGTGGAAGAGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65908	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65909	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65910	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65911	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65912	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65913	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65914	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65915	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65916	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65917	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65918	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AAACAACTCGCACACCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65919	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65920	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65921	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65922	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65923	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65924	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65925	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65926	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65927	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65928	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65929	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				TCAGGTGCCGAGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65930	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65931	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65932	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65933	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65934	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65935	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65936	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65937	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65938	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65939	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65940	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GACTGCATCGGGAAAGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65941	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65942	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65943	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65944	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65945	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65946	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65947	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65948	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65949	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65950	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65951	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				TGCACGCTCTTCCTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65952	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65953	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65954	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65955	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65956	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65957	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65958	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65959	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65960	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65961	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65962	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AGACCACCTGACCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65963	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65964	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65965	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65966	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65967	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65968	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65969	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65970	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65971	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65972	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65973	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CCTGCCCCCACGCGAGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65974	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65975	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65976	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65977	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65978	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65979	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65980	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65981	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65982	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65983	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65984	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CTGGGGTGGACACCCGGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65985	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65986	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65987	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65988	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65989	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65990	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65991	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65992	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65993	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65994	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65995	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GATCGCGGGAAGTTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65996	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65997	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65998	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	65999	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66000	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66001	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66002	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66003	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66004	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66005	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66006	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AGCTCCTTCTTGGGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66007	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66008	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66009	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66010	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66011	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66012	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66013	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66014	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66015	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66016	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66017	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GCCCGGTCTGAGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66018	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66019	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66020	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66021	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66022	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66023	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66024	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66025	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66026	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66027	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66028	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GGGGACACAGAGGGGCGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66029	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66030	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66031	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66032	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66033	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66034	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66035	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66036	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66037	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66038	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66039	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AGGCCTCTCCCTGCATCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66040	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66041	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66042	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66043	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66044	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66045	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66046	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66047	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66048	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66049	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66050	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GTGTGAATGATCCTTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66051	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66052	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66053	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66054	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66055	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66056	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66057	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66058	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66059	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66060	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66061	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				ATGGGGCCAGTCAGGTGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66062	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66063	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66064	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66065	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66066	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66067	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66068	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66069	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66070	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66071	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66072	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				ACTCATGCCATTTCAGCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66073	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66074	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66075	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66076	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66077	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66078	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66079	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66080	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66081	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66082	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66083	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CAGGACGAGTGGTCACCCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66084	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66085	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66086	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66087	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66088	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66089	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66090	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66091	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66092	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66093	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66094	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				TTCTGGCGGACAGGTTACTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66095	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66096	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66097	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66098	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66099	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66100	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66101	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66102	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66103	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66104	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66105	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CGCATGGCATCCTCGGTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66106	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66107	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66108	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66109	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66110	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66111	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66112	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66113	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66114	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66115	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66116	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				TTGCTGTTCCGACCCTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66117	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66118	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66119	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66120	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66121	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66122	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66123	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66124	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66125	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66126	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66127	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AGGCTGCTAGGTCGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66128	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66129	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66130	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66131	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66132	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66133	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66134	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66135	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66136	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66137	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66138	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GCACTGGGTACCCCCAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66139	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66140	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66141	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66142	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66143	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66144	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66145	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66146	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66147	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66148	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66149	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CCAGGCCTGTATGAGTGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66150	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66151	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66152	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66153	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66154	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66155	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66156	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66157	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66158	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66159	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66160	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GGGCCGGGAGACCTGGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66161	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66162	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66163	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66164	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66165	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66166	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66167	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66168	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66169	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66170	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66171	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CCGCCCCGCCTCGAGAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66172	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66173	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66174	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66175	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66176	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66177	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66178	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66179	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66180	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66181	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66182	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				TCGCTACAAAAGCCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66183	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66184	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66185	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66186	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66187	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66188	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66189	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66190	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66191	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66192	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66193	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CGAGCCTGAGGCGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66194	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66195	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66196	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66197	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66198	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66199	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66200	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66201	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66202	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66203	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66204	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				AGCCGCCAGGCCGCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66205	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66206	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66207	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66208	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66209	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66210	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66211	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66212	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66213	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66214	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66215	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				GGCGTCGCCGAGAAGGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66216	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66217	hg19	N/A	enh22874	fant21064	Enhatls147772	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66218	hg19	N/A	enh22874	N/A	Enhatls147772	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66219	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66220	hg19	N/A	enh22874	N/A	Enhatls147773	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66221	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66222	hg19	N/A	enh22874	N/A	Enhatls147774	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66223	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66224	hg19	N/A	enh22874	N/A	Enhatls147775	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66225	hg19	N/A	enh22874	N/A	N/A	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138227	chr5	179243438	179251967	179816438	179824967	66226	hg19	N/A	enh22874	N/A	Enhatls147776	enhancer	E_811				CTGGAGTGGTGACCAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					SQSTM1	chr5	179806407	179838078	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8018
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66227	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				CCCCGGACACCACCTGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66228	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				CACAGGCCGCACGACTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66229	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GTGTTCCTGCAAGCTCGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66230	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				TTAGCAAGATCAGAGGTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66231	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GTGAGATGGGCACGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66232	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GCGGTCTCGCCAACTTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66233	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				ACCTGAGGAGAGCCCGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66234	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				ACACGCACGCCAGCGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66235	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GCTGGCGGCGGGGCTGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66236	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GCGGCGGCCTTACGGGTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66237	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GTCGCTGCAGCACGAAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66238	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GTGCGAGCGGCTCCGCGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66239	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GGAGCGTGCGGAGCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66240	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GCGTGTGGCGCTCCCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66241	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				GTGGGCTGCACCGCTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138256	chr5	179333293	179337156	179906293	179910156	66242	hg19	N/A	N/A	N/A	Enhatls147806	enhancer	E_812				CTGGTTGCGCGTGCAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					TBC1D9B	chr5	179862065	179907897	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8047
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66243	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66244	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66245	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66246	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66247	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66248	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GTGCAGCCGCGAGCAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66249	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66250	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66251	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66252	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66253	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66254	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGTCCCCTCCCGCATCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66255	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66256	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66257	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66258	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66259	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66260	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGAGGGGCCGAGAGCTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66261	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66262	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66263	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66264	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66265	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66266	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				CCATAGGGCCGCCAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66267	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66268	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66269	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66270	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66271	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66272	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GAGCCCGATATTCATTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66273	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66274	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66275	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66276	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66277	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66278	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGTACCCCTCGGCTGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66279	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66280	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66281	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66282	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66283	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66284	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGAAACGTCCAGCCGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66285	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66286	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66287	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66288	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66289	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66290	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				CGGAAAGGGAAAGCAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66291	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66292	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66293	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66294	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66295	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66296	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GTGTCTTTGGGGAAGCTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66297	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66298	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66299	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66300	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66301	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66302	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				TCACCGAAGAGCTTTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66303	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66304	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66305	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66306	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66307	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66308	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GCCTTGGCAGGGGTCCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66309	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66310	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66311	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66312	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66313	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66314	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AACGCAACTCCTTCCCCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66315	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66316	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66317	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66318	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66319	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66320	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				GGCCTCTGGGATAAATCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66321	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66322	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66323	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66324	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66325	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66326	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				AGAGCCTCTCTCTCTGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66327	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66328	hg19	N/A	enh38702	fant21083	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66329	hg19	N/A	enh38702	N/A	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66330	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66331	hg19	N/A	N/A	fant21084	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138279	chr5	179595656	179604914	180168656	180177914	66332	hg19	N/A	N/A	N/A	Enhatls147829	enhancer	E_813				TCTTGTGAAAGGGGCCCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					RASGEF1C	chr5	180100794	180209211	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8070
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66333	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GGAGCACGAGATTTTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66334	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CAGAAGGGAACGACCTACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66335	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GGTGCGCCCGCGGTGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66336	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				AGAGAGCCGGGAACTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66337	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CAGATGTGCGCTCCGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66338	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GGCCGGGCGTCCGATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66339	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CTCTTCCCCGCGCAAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66340	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GGGTCGCGAGGAGGACGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66341	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GCCGGCGCATCCCGAGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	direct	Highly Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66342	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GTGGGGACCCCTCTGTTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66343	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CCTGGTCTCGGACACAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66344	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				TGGGGGCGCCGATCTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66345	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				TTGCGGGCGGAGGCGCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66346	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GCGGCACTCACCGCACATCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66347	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CGGAGGGCTCCGGGTTATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66348	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GTCGTTGTCACGACAACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66349	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GGGTCGGGCGTGTAAGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66350	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GCGGGGCTTAGGGCAACCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66351	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				TCTGACTTCTCAGCACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66352	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				CCGGAGCGCGCGAGTGATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66353	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				GTTCTCTCCACGCAGGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138303	chr5	179776915	179780954	180349915	180353954	66354	hg19	N/A	N/A	N/A	Enhatls147858	enhancer	E_814				TTCGACCCTGGGATTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					GFPT2	chr5	180300697	180353336	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8094
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66355	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GTGGCTGGCCGGCTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66356	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GTGGCTGGCCGGCTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66357	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GTGGCTGGCCGGCTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66358	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GTGTGTGGAGTAGAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66359	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GTGTGTGGAGTAGAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66360	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GTGTGTGGAGTAGAGAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66361	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GAAATATATATATAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66362	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GAAATATATATATAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66363	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GAAATATATATATAATAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66364	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				TCCTTTCCCCAAGTTAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66365	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				TCCTTTCCCCAAGTTAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66366	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				TCCTTTCCCCAAGTTAATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66367	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GATGTTGTGAAACTCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66368	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GATGTTGTGAAACTCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66369	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GATGTTGTGAAACTCGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66370	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GGGATTCCGAAAGCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66371	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GGGATTCCGAAAGCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66372	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GGGATTCCGAAAGCAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66373	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				CCATGAGTGCTAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66374	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				CCATGAGTGCTAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66375	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				CCATGAGTGCTAGCGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66376	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GACGGAGGTCAGACCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66377	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GACGGAGGTCAGACCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66378	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GACGGAGGTCAGACCGGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66379	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				CTTGGCCTGCTCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66380	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				CTTGGCCTGCTCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66381	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				CTTGGCCTGCTCCGGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66382	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				TGGCGAGTCGAAAGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66383	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				TGGCGAGTCGAAAGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66384	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				TGGCGAGTCGAAAGGCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66385	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				CGTGGCCCTTCCCCGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66386	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				CGTGGCCCTTCCCCGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66387	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				CGTGGCCCTTCCCCGGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66388	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GGGTTGACTGAGAAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66389	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GGGTTGACTGAGAAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66390	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GGGTTGACTGAGAAGCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66391	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				GCAGCTGCGCTGGAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66392	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				GCAGCTGCGCTGGAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66393	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				GCAGCTGCGCTGGAGGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66394	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				CTGAAGTGGGCCCGCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66395	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				CTGAAGTGGGCCCGCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66396	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				CTGAAGTGGGCCCGCAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66397	hg19	N/A	enh22884	N/A	Enhatls147901	enhancer	E_815				ACAGGAACCAGGGTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138347	chr5	180227289	180238568	180800289	180811568	66398	hg19	N/A	N/A	N/A	Enhatls147901	enhancer	E_815				ACAGGAACCAGGGTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8138
enhrx-138348	chr5	180227289	180238568	180800289	180811568	66399	hg19	N/A	N/A	N/A	Enhatls147902	enhancer	E_815				ACAGGAACCAGGGTGCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	SQSTM1	indirect	Non Significant	NA					MGAT1	chr5	180784779	180815580	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	8139
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66400	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CTAGTCCCAGTTCTGTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	indirect	Non Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66401	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CAGAAATGTAAATAATCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66402	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				TAAATAAATGATAAGATGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66403	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				AGCTACAAACGACCATTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66404	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CTATCCCTAAAACTTCCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66405	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CATGATTTGTCCTAGTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66406	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				GCTGAATATCTCTCTATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66407	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				GCCAAGTATTTAGAGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66408	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				TTAGGTGGAGTAAGTAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66409	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				GACTCTTGAGAGGAAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66410	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				GATAATTATGCCTGTAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66411	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				TCAGTGCAGATATTATGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66412	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CTTTGCTGTATCCTGTAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66413	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				TCTATGCAAAGACTTCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66414	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				CAACTTTAAAGGGAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66415	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				GTCAGTTGCAACTGACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	9481233	9483878	9481000	9483645	66416	hg19	N/A	enh22989	N/A	Enhatls148384	enhancer	E_817				ATCAAGCATTAATAGGTGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	904940				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66417	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				CAGGCCGTGGCCAATTTGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66418	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				GAAGATTGCACGGTATGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66419	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				CCAGGTGAGAAAAGTCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66420	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				GACCTCATGTGATTAAGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66421	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				GAGTAACAGTAAATCACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66422	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				CTTAGTCATCTGCTTGCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66423	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				GTTCAGACAAGAAGCTTTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66424	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				AGTATGTGGTCACACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66425	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				AGGCAACATGTATAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	direct	Highly Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66426	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				CTAGTCCAGGACATCAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	indirect	Non Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66427	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				TCACCACACTACTAGACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	indirect	Non Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-138797	chr6	10303497	10304901	10303264	10304668	66428	hg19	N/A	enh22999	N/A	Enhatls148385	enhancer	E_818				GAATGATCTGATGCCTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TFAP2A	indirect	Non Significant	NA					TFAP2A	chr6	10393185	10419638	78140				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	385
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66429	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				GTTTGACATAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66430	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				GTTTGACATAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66431	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				GTTTGACATAGTTTCTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66432	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ACAACTGCGGCACAAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66433	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				ACAACTGCGGCACAAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66434	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ACAACTGCGGCACAAATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66435	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				GGATTCATCGCCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66436	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				GGATTCATCGCCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66437	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				GGATTCATCGCCACCAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66438	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				CTGGTACCTAAAAATAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66439	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				CTGGTACCTAAAAATAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66440	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				CTGGTACCTAAAAATAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66441	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ACTTACTGGCTGTCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66442	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				ACTTACTGGCTGTCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66443	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ACTTACTGGCTGTCTACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66444	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				CCCACGCCAGGACAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66445	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				CCCACGCCAGGACAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66446	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				CCCACGCCAGGACAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66447	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				TCGCTTCCCAGCGCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66448	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				TCGCTTCCCAGCGCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66449	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				TCGCTTCCCAGCGCCTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66450	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				AGTACACAGCATTTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66451	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				AGTACACAGCATTTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66452	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				AGTACACAGCATTTGCTCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66453	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				TAATATAGAACGCCGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66454	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				TAATATAGAACGCCGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66455	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				TAATATAGAACGCCGCCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66456	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ATGCAGAAACAAGGGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66457	hg19	N/A	enh8974	fant21788	Enhatls148655	enhancer	E_823				ATGCAGAAACAAGGGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139044	chr6	16317213	16321781	16316982	16321550	66458	hg19	N/A	enh8974	N/A	Enhatls148655	enhancer	E_823				ATGCAGAAACAAGGGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	indirect	Non Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	632
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66459	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ATGCACACCAACAAGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66460	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				ATGCACACCAACAAGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66461	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ATGCACACCAACAAGAAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66462	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				CATTGCACTTAACCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66463	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				CATTGCACTTAACCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66464	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				CATTGCACTTAACCCTTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66465	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ACAGCTGGCAGCCTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66466	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				ACAGCTGGCAGCCTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66467	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ACAGCTGGCAGCCTTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66468	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				GCAACTGCTCCAGGAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66469	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				GCAACTGCTCCAGGAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66470	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				GCAACTGCTCCAGGAGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66471	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ATGTTCTCTGTTGTAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66472	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				ATGTTCTCTGTTGTAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66473	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				ATGTTCTCTGTTGTAGACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66474	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				AGTCAGGAAAAAGGTCTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66475	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				AGTCAGGAAAAAGGTCTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66476	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				AGTCAGGAAAAAGGTCTCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66477	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				TTAAAACTATTCACTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66478	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				TTAAAACTATTCACTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66479	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				TTAAAACTATTCACTGTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66480	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				GTAAGCCAGTGTGTGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66481	hg19	N/A	enh8975	fant21791	Enhatls148656	enhancer	E_824				GTAAGCCAGTGTGTGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16338246	16340389	16338015	16340158	66482	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_824				GTAAGCCAGTGTGTGACACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66483	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				TGTTAAAGACACTTGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66484	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				TGTTAAAGACACTTGCTATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66485	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				AGTAAATCCAGAGACTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66486	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				AGTAAATCCAGAGACTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66487	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				AACCAGCCTAAATCAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66488	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				AACCAGCCTAAATCAATCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66489	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				ACTCACACTCGGTGAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66490	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				ACTCACACTCGGTGAATGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66491	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				AAGTAGGCTTCCCACTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66492	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				AAGTAGGCTTCCCACTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66493	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				TAGTGACTGGAAACAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66494	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				TAGTGACTGGAAACAACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66495	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				GCGGCCCAGCACAAAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66496	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				GCGGCCCAGCACAAAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66497	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				AAGTTAATGACGCTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66498	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				AAGTTAATGACGCTGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66499	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				ACCGCCCTCACACTTCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66500	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				ACCGCCCTCACACTTCCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66501	hg19	N/A	enh8975	N/A	Enhatls148656	enhancer	E_825				TTTGAGACAGTAGCCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-139045	chr6	16343713	16348664	16343482	16348433	66502	hg19	N/A	N/A	N/A	Enhatls148656	enhancer	E_825				TTTGAGACAGTAGCCAGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	JARID2	direct	Highly Significant	NA					ATXN1	chr6	16299111	16761460	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	633
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66503	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				ATCTCTCAGACAGTCTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66504	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				ATCTCTCAGACAGTCTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66505	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				ATCTCTCAGACAGTCTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66506	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				ATCTCTCAGACAGTCTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66507	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				ATCTCTCAGACAGTCTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66508	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				GGGAGAGTGGAGGAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66509	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GGGAGAGTGGAGGAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66510	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				GGGAGAGTGGAGGAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66511	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GGGAGAGTGGAGGAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66512	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				GGGAGAGTGGAGGAGCCGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66513	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				TGGGAAGTGTGCGTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66514	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				TGGGAAGTGTGCGTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66515	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				TGGGAAGTGTGCGTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66516	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				TGGGAAGTGTGCGTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66517	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				TGGGAAGTGTGCGTTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66518	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				GTGGAGAGACGCGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66519	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GTGGAGAGACGCGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66520	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				GTGGAGAGACGCGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66521	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GTGGAGAGACGCGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66522	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				GTGGAGAGACGCGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66523	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				TAGGAAAACACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66524	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				TAGGAAAACACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66525	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				TAGGAAAACACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66526	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				TAGGAAAACACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66527	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				TAGGAAAACACCCCAGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66528	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				CGGGAGGCCGCGGGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66529	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				CGGGAGGCCGCGGGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66530	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				CGGGAGGCCGCGGGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66531	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				CGGGAGGCCGCGGGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66532	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				CGGGAGGCCGCGGGACACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66533	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				AAGACAGGAAGATTTAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66534	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				AAGACAGGAAGATTTAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66535	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				AAGACAGGAAGATTTAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66536	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				AAGACAGGAAGATTTAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66537	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				AAGACAGGAAGATTTAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66538	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				GAGGCCTGAAGGGTACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66539	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGCCTGAAGGGTACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66540	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				GAGGCCTGAAGGGTACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66541	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGCCTGAAGGGTACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66542	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGCCTGAAGGGTACGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66543	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				GAGGGTTCTGACCATCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66544	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGGTTCTGACCATCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66545	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				GAGGGTTCTGACCATCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66546	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGGTTCTGACCATCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66547	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				GAGGGTTCTGACCATCCCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66548	hg19	N/A	N/A	N/A	Enhatls150950	enhancer	E_826				AGGGGTCGGCTGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	86457				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66549	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				AGGGGTCGGCTGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	87074				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66550	hg19	N/A	enh23240	fant22563	Enhatls150950	enhancer	E_826				AGGGGTCGGCTGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93542				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66551	hg19	N/A	enh23240	N/A	Enhatls150950	enhancer	E_826				AGGGGTCGGCTGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					NCR2	chr6	41335607	41350889	93608				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-141201	chr6	41405579	41418026	41437841	41450288	66552	hg19	hs2104	enh23240	N/A	Enhatls150950	enhancer	E_826				AGGGGTCGGCTGGCTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"TFEB,FRS3"	direct	Highly Significant	NA					FOXP4	chr6	41546380	41602384	95193				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66553	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				ACTTAAGCTCATCTTTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66554	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				CATTTGCAAATGCAGTCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66555	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				TTTTTTTCAGAAAGAATTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66556	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				CATGCATCTTTCCTTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66557	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				GCTCAGCCACAAGAGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66558	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				AGTCCCGTTGGCGGACGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66559	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				GTTGTCTCTGGACCTCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66560	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				TCGCAATTGACTGCATGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66561	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				CCGTAAGCTGGGCTCCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66562	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				GTTGGGGATCTTTTTTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-143766	chr6	99840008	99842949	99392132	99395073	66563	hg19	N/A	N/A	N/A	Enhatls153644	enhancer	E_828				CAGAGTCTGTTCTGTTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	CCNC	direct	Highly Significant	NA					COQ3	chr6	99369400	99394195	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5354
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66564	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				GACATGATGATTGATTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66565	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				GACATGATGATTGATTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66566	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				GACATGATGATTGATTGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66567	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TCTGGAATGATGCCCCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66568	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				TCTGGAATGATGCCCCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66569	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TCTGGAATGATGCCCCGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66570	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AGACAGCCCATTCTGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66571	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				AGACAGCCCATTCTGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66572	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AGACAGCCCATTCTGGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66573	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TAGCTTTCCCTTTAGTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66574	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				TAGCTTTCCCTTTAGTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66575	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TAGCTTTCCCTTTAGTCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66576	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TACCATGATTCATCGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66577	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				TACCATGATTCATCGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66578	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TACCATGATTCATCGTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66579	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				CACACGCTACAGCATGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66580	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				CACACGCTACAGCATGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66581	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				CACACGCTACAGCATGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66582	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TGATTATCAGGCATGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66583	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				TGATTATCAGGCATGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66584	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				TGATTATCAGGCATGTGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66585	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				ATGAACGCCCTTTCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66586	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				ATGAACGCCCTTTCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66587	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				ATGAACGCCCTTTCATCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66588	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AACATGCTTCACGTGATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66589	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				AACATGCTTCACGTGATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66590	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AACATGCTTCACGTGATTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66591	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AAAATACAGCATATCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	153214				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66592	hg19	N/A	enh39481	fant24067	Enhatls155062	enhancer	E_829				AAAATACAGCATATCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159224				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-145107	chr6	130921158	130925757	130600013	130604612	66593	hg19	N/A	enh39481	N/A	Enhatls155062	enhancer	E_829				AAAATACAGCATATCTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MED23	direct	Highly Significant	NA					TMEM200A	chr6	130366016	130443067	159611				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6695
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66594	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GTGAGTCTGTCAGAGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66595	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GCAGCGCGGTCACCAGCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66596	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				TCAGCAGCCACGACACCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66597	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GTGAGCCGCACAACAGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66598	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				CCTGCTTTGCGCCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66599	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GGGTCTGACCGGCCTTCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66600	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GGGCCACACTGCCGTGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66601	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GATACCACCCCAAAGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66602	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				AAAGGCTTTCAGCAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66603	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GGACTGTGCAGGGCCATCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66604	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				GCTGCCCTGAGCAATGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147671	chr7	5526241	5527030	5486610	5487399	66605	hg19	N/A	enh9578	N/A	Enhatls157810	enhancer	E_831				TTCTGTGAGGCTTGAACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	483
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66606	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				CCTCAGGGGACGGAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66607	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				CCTCAGGGGACGGAGAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66608	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				GATGCGGGAAGGACGGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66609	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				GATGCGGGAAGGACGGGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66610	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				GTCGGGATAGAAAGGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66611	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				GTCGGGATAGAAAGGATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66612	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				AAGCAGAGCGGAGACAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66613	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				AAGCAGAGCGGAGACAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66614	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				GCGGGTCCGAACCGCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66615	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				GCGGGTCCGAACCGCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66616	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				CGAGAGCCCGCTCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66617	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				CGAGAGCCCGCTCCTTGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66618	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				CGGAGCCACATTCAACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66619	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				CGGAGCCACATTCAACATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66620	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				GGAACGTGCTAGGCCGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66621	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				GGAACGTGCTAGGCCGGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66622	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				CGTGTGTGAAGGTAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66623	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				CGTGTGTGAAGGTAGAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66624	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				TTTTTGCACCATCTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66625	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				TTTTTGCACCATCTGACCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66626	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				TCAGTGTCTATCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66627	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				TCAGTGTCTATCACATTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66628	hg19	N/A	enh39853	N/A	Enhatls157813	enhancer	E_832				AACGCAAACGCTTAAGTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147674	chr7	5547612	5554849	5507981	5515218	66629	hg19	N/A	N/A	N/A	Enhatls157813	enhancer	E_832				AACGCAAACGCTTAAGTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FBXL18	chr7	5475796	5513809	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	486
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66630	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66631	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66632	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66633	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66634	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66635	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66636	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66637	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66638	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66639	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAAGAAGGAGAGGGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66640	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66641	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66642	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66643	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66644	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66645	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66646	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66647	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66648	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66649	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GACAGAAGTAACATCCGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66650	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66651	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66652	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66653	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66654	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66655	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66656	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66657	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66658	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66659	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CGGGACACCATTCCTGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66660	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66661	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66662	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66663	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66664	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66665	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66666	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66667	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66668	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66669	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAATAGCGCTAGGGAGGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66670	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66671	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66672	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66673	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66674	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66675	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66676	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66677	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66678	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66679	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CAGGAAGTGCCTGGGTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66680	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66681	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66682	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66683	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66684	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66685	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66686	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66687	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66688	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66689	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				AGTCATTGATTCATTCCCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66690	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66691	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66692	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66693	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66694	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66695	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66696	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66697	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66698	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66699	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GTTAGAGGCTGACCTGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66700	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66701	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66702	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66703	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66704	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66705	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66706	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66707	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66708	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66709	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTCCTGAGGAAGGGTCTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66710	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66711	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66712	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66713	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66714	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66715	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66716	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66717	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66718	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66719	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTTAGGGAGGGGTTGACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66720	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66721	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66722	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66723	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66724	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66725	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66726	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66727	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66728	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66729	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGAGACTCTAGCCCTGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66730	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66731	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66732	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66733	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66734	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66735	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66736	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66737	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66738	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66739	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGCGGGGGCCGACTCTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66740	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66741	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66742	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66743	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66744	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66745	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66746	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66747	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66748	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66749	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GTCCGCGCTGGACTCGCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66750	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66751	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66752	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66753	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66754	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66755	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66756	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66757	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66758	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66759	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				AAGTGGGCCGGGCCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66760	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66761	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66762	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66763	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66764	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66765	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66766	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66767	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66768	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66769	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGAGGGGGCGTTGGGTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66770	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66771	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66772	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66773	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66774	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66775	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66776	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66777	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66778	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66779	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGCGAGCCCTCGCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66780	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66781	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66782	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66783	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66784	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66785	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66786	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66787	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66788	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66789	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGGGACTCGCGGGGACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66790	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66791	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66792	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66793	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66794	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66795	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66796	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66797	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66798	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66799	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGTTCAGTCCCCAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66800	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66801	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66802	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66803	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66804	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66805	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66806	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66807	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66808	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66809	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				ACACGAACCCTTCTGCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66810	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66811	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66812	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66813	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66814	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66815	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66816	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66817	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66818	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66819	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TTAGCATTTGATGACGCTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66820	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66821	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66822	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66823	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66824	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66825	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66826	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66827	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66828	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66829	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGACCAATAGGAAGTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66830	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66831	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66832	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66833	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66834	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66835	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66836	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66837	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66838	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66839	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TCCGAGCCCACCCATCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66840	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66841	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66842	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66843	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66844	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66845	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66846	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66847	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66848	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66849	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGCCGACATCCAGCTCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66850	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66851	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66852	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66853	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66854	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66855	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66856	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66857	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66858	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66859	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGCACGGCCACACAGACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66860	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66861	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66862	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66863	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66864	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66865	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66866	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66867	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66868	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66869	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CGTCTGCGAGCCTGATCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66870	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66871	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66872	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66873	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66874	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66875	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66876	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66877	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66878	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66879	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CTGATACCTCCTTCCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66880	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66881	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66882	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66883	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66884	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66885	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66886	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66887	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66888	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66889	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAGACGATAGGGGTGAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66890	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66891	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66892	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66893	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66894	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66895	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66896	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66897	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66898	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66899	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				ATTCTGCTGAGTCACTTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66900	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66901	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66902	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66903	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66904	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66905	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66906	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66907	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66908	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66909	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGGAGGAGGGGCTAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66910	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66911	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66912	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66913	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66914	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66915	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66916	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66917	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66918	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66919	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CAGACATCTACAGGCACCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66920	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66921	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66922	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66923	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66924	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66925	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66926	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66927	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66928	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66929	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCAGGGACGGAGGTTCCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66930	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66931	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66932	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66933	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66934	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66935	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66936	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66937	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66938	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66939	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CTGAGTCTGCCCTCAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66940	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66941	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66942	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66943	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66944	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66945	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66946	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66947	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66948	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66949	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GAGGGCCTGTTTTATCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66950	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66951	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66952	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66953	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66954	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66955	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66956	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66957	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66958	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66959	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				TGGAGTGAAGGTCCAAGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66960	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66961	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66962	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66963	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66964	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66965	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66966	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66967	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66968	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66969	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCATAACTGTCCCAAGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66970	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66971	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66972	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66973	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66974	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66975	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66976	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66977	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66978	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66979	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGCCTAATTCACCTAATTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66980	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66981	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66982	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66983	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66984	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66985	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66986	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66987	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66988	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66989	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				CCGGAACAAACGATGCAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66990	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66991	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66992	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66993	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66994	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66995	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66996	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66997	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66998	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	66999	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGAGGGCGCGCGGGTTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67000	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67001	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67002	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67003	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67004	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67005	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67006	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67007	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67008	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67009	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GCGTCGGTTGCGCCACCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67010	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67011	hg19	N/A	enh9580	fant25488	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67012	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67013	hg19	N/A	enh9580	fant25489	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67014	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67015	hg19	N/A	enh9580	fant25490	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67016	hg19	N/A	enh9580	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67017	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67018	hg19	N/A	N/A	fant25491	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5585817	5604752	5546186	5565121	67019	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_833				GGGCTGGACTCGTCCGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67020	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AAGTCACAGGGATATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67021	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				AAGTCACAGGGATATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67022	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AAGTCACAGGGATATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67023	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				AAGTCACAGGGATATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67024	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AAGTCACAGGGATATGCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67025	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCTTTGTCTGTATTCATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67026	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GCTTTGTCTGTATTCATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67027	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCTTTGTCTGTATTCATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67028	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GCTTTGTCTGTATTCATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67029	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCTTTGTCTGTATTCATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67030	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCGATCTCAGGGCTGTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67031	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GCGATCTCAGGGCTGTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67032	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCGATCTCAGGGCTGTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67033	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GCGATCTCAGGGCTGTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67034	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCGATCTCAGGGCTGTTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67035	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCAGTCATCGCTCTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67036	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GCAGTCATCGCTCTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67037	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCAGTCATCGCTCTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67038	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GCAGTCATCGCTCTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67039	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GCAGTCATCGCTCTAGGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67040	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGTGCACTGCCACACATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67041	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				TGTGCACTGCCACACATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67042	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGTGCACTGCCACACATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67043	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				TGTGCACTGCCACACATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67044	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGTGCACTGCCACACATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67045	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TTGGTAGAGGATGTGGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67046	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				TTGGTAGAGGATGTGGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67047	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TTGGTAGAGGATGTGGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67048	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				TTGGTAGAGGATGTGGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67049	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TTGGTAGAGGATGTGGCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67050	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTTTCTGGCCTAGATCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67051	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GTTTCTGGCCTAGATCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67052	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTTTCTGGCCTAGATCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67053	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GTTTCTGGCCTAGATCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67054	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTTTCTGGCCTAGATCCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67055	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GGGCTGTGATCCAGATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67056	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GGGCTGTGATCCAGATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67057	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GGGCTGTGATCCAGATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67058	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GGGCTGTGATCCAGATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67059	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GGGCTGTGATCCAGATTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67060	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCTTGAAGAGCGCACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67061	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				CCTTGAAGAGCGCACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67062	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCTTGAAGAGCGCACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67063	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				CCTTGAAGAGCGCACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67064	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCTTGAAGAGCGCACACCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67065	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCAGCTGCGCCCACAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67066	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				CCAGCTGCGCCCACAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67067	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCAGCTGCGCCCACAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67068	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				CCAGCTGCGCCCACAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67069	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CCAGCTGCGCCCACAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67070	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGCGGTGGGACACCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67071	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				TGCGGTGGGACACCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67072	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGCGGTGGGACACCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67073	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				TGCGGTGGGACACCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67074	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGCGGTGGGACACCCGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67075	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				ATGATTGGTCCATTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67076	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				ATGATTGGTCCATTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67077	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				ATGATTGGTCCATTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67078	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				ATGATTGGTCCATTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67079	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				ATGATTGGTCCATTTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67080	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CTACTACGACCCCCCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67081	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				CTACTACGACCCCCCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67082	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CTACTACGACCCCCCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67083	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				CTACTACGACCCCCCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67084	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CTACTACGACCCCCCCGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67085	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAATTTTCCCCTCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67086	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				CGAATTTTCCCCTCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67087	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAATTTTCCCCTCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67088	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				CGAATTTTCCCCTCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67089	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAATTTTCCCCTCTCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67090	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTCTGGGAACAAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67091	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				GTCTGGGAACAAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67092	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTCTGGGAACAAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67093	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				GTCTGGGAACAAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67094	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				GTCTGGGAACAAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67095	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AGGGGGATGGTGGACTTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67096	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				AGGGGGATGGTGGACTTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67097	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AGGGGGATGGTGGACTTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67098	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				AGGGGGATGGTGGACTTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67099	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				AGGGGGATGGTGGACTTATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67100	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAGTCATACAGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67101	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				CGAGTCATACAGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67102	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAGTCATACAGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67103	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				CGAGTCATACAGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67104	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				CGAGTCATACAGCAGTCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67105	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGGGGAGGAGTGGGATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67106	hg19	N/A	N/A	fant25492	Enhatls157820	enhancer	E_834				TGGGGAGGAGTGGGATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5689				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67107	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGGGGAGGAGTGGGATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	5892				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67108	hg19	N/A	N/A	fant25493	Enhatls157820	enhancer	E_834				TGGGGAGGAGTGGGATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6009				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147681	chr7	5606272	5610448	5566641	5570817	67109	hg19	N/A	N/A	N/A	Enhatls157820	enhancer	E_834				TGGGGAGGAGTGGGATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					ACTB	chr7	5526408	5563902	6633				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	493
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67110	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67111	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67112	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67113	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67114	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67115	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67116	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67117	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67118	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AGAAAGTCCTGGGGACCTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67119	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67120	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67121	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67122	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67123	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67124	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67125	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67126	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67127	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TTTGTCCTCGGAGTATTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67128	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67129	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67130	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67131	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67132	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67133	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67134	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67135	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67136	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AGTTCTGTAGCAGTGCTCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67137	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67138	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67139	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67140	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67141	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67142	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67143	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67144	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67145	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				ACAATTATCGCCTAGCCATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67146	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67147	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67148	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67149	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67150	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67151	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67152	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67153	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67154	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CCAGTTCAAATAAAACCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67155	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67156	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67157	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67158	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67159	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67160	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67161	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67162	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67163	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GCCAAAACCCAAGACAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67164	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67165	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67166	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67167	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67168	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67169	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67170	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67171	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67172	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GAGCAAATTGTGAGAGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67173	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67174	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67175	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67176	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67177	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67178	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67179	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67180	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67181	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CTGAACGTGAATATACTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67182	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67183	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67184	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67185	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67186	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67187	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67188	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67189	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67190	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				ACAGACGTTATTTTGCAGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67191	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67192	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67193	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67194	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67195	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67196	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67197	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67198	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67199	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AACTAAGAGTCTTATAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67200	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67201	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67202	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67203	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67204	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67205	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67206	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67207	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67208	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CTTGAGCTCTTACTGTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67209	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67210	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67211	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67212	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67213	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67214	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67215	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67216	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67217	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AATCTCTTATTTGTCAGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67218	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67219	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67220	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67221	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67222	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67223	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67224	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67225	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67226	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GGTTAATTAAGCCAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67227	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67228	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67229	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67230	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67231	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67232	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67233	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67234	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67235	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GGGCTGATCGCTGTTTTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67236	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67237	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67238	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67239	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67240	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67241	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67242	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67243	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67244	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TGGCTATCAGAGGAAATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67245	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67246	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67247	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67248	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67249	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67250	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67251	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67252	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67253	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GCAAATCTAGAAACTTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67254	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67255	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67256	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67257	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67258	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67259	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67260	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67261	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67262	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CATGCTATGGCACCCAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67263	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67264	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67265	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67266	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67267	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67268	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67269	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67270	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67271	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GTGGGAGTTAGCGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67272	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67273	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67274	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67275	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67276	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67277	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67278	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67279	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67280	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GGAGCTATGAAGAGCTCCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67281	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67282	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67283	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67284	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67285	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67286	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67287	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67288	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67289	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CCACTGTGCTAGCTGCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67290	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67291	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67292	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67293	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67294	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67295	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67296	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67297	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67298	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TGGGAATGTCTGTCACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67299	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67300	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67301	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67302	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67303	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67304	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67305	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67306	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67307	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CACATCTCCTTAGTGACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67308	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67309	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67310	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67311	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67312	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67313	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67314	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67315	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67316	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AGGCTTAAAATGGAGAGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67317	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67318	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67319	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67320	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67321	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67322	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67323	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67324	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67325	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TAGAGACAGTTTCACCATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67326	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67327	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67328	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67329	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67330	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67331	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67332	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67333	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67334	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TAGGCTGGGGTGCAGTGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67335	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67336	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67337	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67338	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67339	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67340	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67341	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67342	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67343	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AAAACATTGTCAAGGAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67344	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67345	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67346	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67347	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67348	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67349	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67350	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67351	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67352	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CATAAACGGATGTACTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67353	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67354	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67355	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67356	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67357	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67358	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67359	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67360	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67361	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TGAGTAACTAAAATCATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67362	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67363	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67364	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67365	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67366	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67367	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67368	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67369	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67370	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				ACTCAACGTTCTACAACTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67371	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67372	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67373	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67374	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67375	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67376	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67377	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67378	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67379	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CTTGCTCTGTCACCTAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67380	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67381	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67382	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67383	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67384	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67385	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67386	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67387	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67388	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GGGAGAATCTCTTGAACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67389	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67390	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67391	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67392	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67393	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67394	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67395	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67396	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67397	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CAGTGAGTCTCAAAAAAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67398	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67399	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67400	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67401	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67402	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67403	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67404	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67405	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67406	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CATGTGAACCGTTTGAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67407	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67408	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67409	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67410	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67411	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67412	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67413	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67414	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67415	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TTAGAACCTTGAGTCTAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67416	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67417	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67418	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67419	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67420	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67421	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67422	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67423	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67424	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AGAAAATTGCAGTTGTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67425	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67426	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67427	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67428	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67429	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67430	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67431	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67432	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67433	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TGAGGTGCGGCTTTAAGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67434	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67435	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67436	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67437	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67438	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67439	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67440	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67441	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67442	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AAGCTGCTCAAGGAGAGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67443	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67444	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67445	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67446	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67447	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67448	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67449	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67450	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67451	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				AGGTTACAGTCTTTTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67452	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67453	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67454	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67455	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67456	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67457	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67458	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67459	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67460	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GCACTGACATGAAATAATAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67461	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67462	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67463	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67464	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67465	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67466	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67467	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67468	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67469	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GCAGAAGCAAAGGACTTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67470	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67471	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67472	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67473	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67474	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67475	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67476	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67477	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67478	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				GCCAGAATGGAGTTTTATTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67479	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67480	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67481	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67482	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67483	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67484	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67485	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67486	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67487	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CCCCGGGAGCACATCCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67488	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67489	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67490	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67491	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67492	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67493	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67494	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67495	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67496	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				CGCTCACACAGGAAGGCTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67497	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67498	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67499	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67500	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67501	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67502	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67503	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67504	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67505	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				TCAGAATATGGCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147687	chr7	5662442	5686933	5622811	5647302	67506	hg19	N/A	N/A	N/A	Enhatls157826	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	499
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67507	hg19	N/A	enh23947	N/A	N/A	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67508	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67509	hg19	hs1623	enh23947	N/A	Enhatls157827	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67510	hg19	N/A	enh23947	N/A	Enhatls157827	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67511	hg19	N/A	N/A	N/A	Enhatls157827	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67512	hg19	N/A	enh46317	N/A	Enhatls157827	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67513	hg19	N/A	enh46317	N/A	N/A	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147688	chr7	5662442	5686933	5622811	5647302	67514	hg19	N/A	enh46317	N/A	Enhatls157828	enhancer	E_835				ATGCATCTTCACGCTCACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	500
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67515	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GGAACAAGTAAAAGGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67516	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				GGAACAAGTAAAAGGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67517	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GGAACAAGTAAAAGGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67518	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				GGAACAAGTAAAAGGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67519	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GGAACAAGTAAAAGGCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67520	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAGCGGTCATAGCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67521	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				AAAGCGGTCATAGCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67522	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAGCGGTCATAGCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67523	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				AAAGCGGTCATAGCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67524	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAGCGGTCATAGCAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67525	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAAGCCATACTAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67526	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				AAAAGCCATACTAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67527	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAAGCCATACTAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67528	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				AAAAGCCATACTAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67529	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AAAAGCCATACTAATTCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67530	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				TCTGCTTGCAGCACAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67531	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				TCTGCTTGCAGCACAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67532	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				TCTGCTTGCAGCACAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67533	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				TCTGCTTGCAGCACAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67534	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				TCTGCTTGCAGCACAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67535	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GCCCGTGCAGAAGGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67536	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				GCCCGTGCAGAAGGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67537	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GCCCGTGCAGAAGGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67538	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				GCCCGTGCAGAAGGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67539	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				GCCCGTGCAGAAGGCGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67540	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AGTGCCTTGCCTCGGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67541	hg19	N/A	enh9582	fant25499	Enhatls157832	enhancer	E_836				AGTGCCTTGCCTCGGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67542	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AGTGCCTTGCCTCGGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67543	hg19	N/A	enh9582	fant25500	Enhatls157832	enhancer	E_836				AGTGCCTTGCCTCGGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5730421	5733130	5690790	5693499	67544	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_836				AGTGCCTTGCCTCGGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67545	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GTAAAAAGCCCCTAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67546	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				GTAAAAAGCCCCTAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67547	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GTAAAAAGCCCCTAAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67548	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TCAATTCTGTCAGATCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67549	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				TCAATTCTGTCAGATCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67550	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TCAATTCTGTCAGATCATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67551	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				AATCCAATCTGCTGAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67552	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				AATCCAATCTGCTGAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67553	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				AATCCAATCTGCTGAGGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67554	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				ATTCACAGTCCATCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67555	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				ATTCACAGTCCATCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67556	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				ATTCACAGTCCATCTTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67557	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				CCCTTCATGTCCAGTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67558	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				CCCTTCATGTCCAGTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67559	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				CCCTTCATGTCCAGTGTAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67560	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TTCCACTTGCAGTGATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67561	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				TTCCACTTGCAGTGATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67562	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TTCCACTTGCAGTGATGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67563	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GTGGTAGCTGAGAACGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67564	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				GTGGTAGCTGAGAACGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67565	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GTGGTAGCTGAGAACGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67566	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				CCTAAGCTGAAGCTGCTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67567	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				CCTAAGCTGAAGCTGCTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67568	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				CCTAAGCTGAAGCTGCTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67569	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TGGGTGTCTGTGTCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67570	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				TGGGTGTCTGTGTCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67571	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TGGGTGTCTGTGTCAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67572	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TCTCAGCACAGAGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67573	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				TCTCAGCACAGAGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67574	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				TCTCAGCACAGAGCACTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67575	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GCGGCTTGTGGTGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67576	hg19	N/A	enh9582	fant25503	Enhatls157832	enhancer	E_837				GCGGCTTGTGGTGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147689	chr7	5738995	5740566	5699364	5700935	67577	hg19	N/A	enh9582	N/A	Enhatls157832	enhancer	E_837				GCGGCTTGTGGTGTGTGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	501
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67578	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				GGTGACTCGCCTGTTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67579	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				GGTGACTCGCCTGTTATCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67580	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				ATTTTTTCTTTGACCACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67581	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				ATTTTTTCTTTGACCACAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67582	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				GCTAATTTAGTTGAAATGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67583	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				GCTAATTTAGTTGAAATGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67584	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				CCACTGGTGTGCCACTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67585	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				CCACTGGTGTGCCACTCATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67586	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				TAAATGTAAGTCTCTGTATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67587	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				TAAATGTAAGTCTCTGTATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67588	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				TTTCCCATTTAGTCAATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67589	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				TTTCCCATTTAGTCAATCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67590	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				TCAGCAACCACAGTAAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67591	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				TCAGCAACCACAGTAAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67592	hg19	N/A	enh86659	N/A	Enhatls157842	enhancer	E_838				CCGCCTATGCTGGAGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147699	chr7	5811593	5816934	5771962	5777303	67593	hg19	N/A	N/A	N/A	Enhatls157842	enhancer	E_838				CCGCCTATGCTGGAGTGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	511
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67594	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				AAAAAATTAGCTCGGTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67595	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				AAAAAATTAGCTCGGTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67596	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				AAAAAATTAGCTCGGTGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67597	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				TGGCTAACACGGTGAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67598	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				TGGCTAACACGGTGAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67599	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				TGGCTAACACGGTGAAACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67600	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				TAGAGTGAATTATAAACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67601	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				TAGAGTGAATTATAAACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67602	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				TAGAGTGAATTATAAACAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67603	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CCACAGGTAGAATCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67604	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CCACAGGTAGAATCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67605	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CCACAGGTAGAATCTACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67606	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CAGGTTTGCACATCAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67607	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CAGGTTTGCACATCAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67608	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CAGGTTTGCACATCAGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67609	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CTCTGTGTCAACCAGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67610	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CTCTGTGTCAACCAGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67611	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CTCTGTGTCAACCAGAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67612	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CATGGCGTCGTGGGGGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67613	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CATGGCGTCGTGGGGGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67614	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CATGGCGTCGTGGGGGGTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67615	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				AGTCTGGGGTCCGGAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67616	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				AGTCTGGGGTCCGGAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67617	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				AGTCTGGGGTCCGGAAGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67618	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CCTCAGACACGCGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67619	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CCTCAGACACGCGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67620	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CCTCAGACACGCGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67621	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				GCAGAGCCGGCACTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67622	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				GCAGAGCCGGCACTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67623	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				GCAGAGCCGGCACTGCACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67624	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				GGACGGTGGGGTCCGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67625	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				GGACGGTGGGGTCCGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67626	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				GGACGGTGGGGTCCGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67627	hg19	N/A	enh9583	N/A	N/A	enhancer	E_839				CTAGCTCACCTGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	38779				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67628	hg19	N/A	enh9583	N/A	Enhatls157844	enhancer	E_839				CTAGCTCACCTGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	41834				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147701	chr7	5862133	5864862	5822502	5825231	67629	hg19	N/A	N/A	N/A	Enhatls157844	enhancer	E_839				CTAGCTCACCTGCGTCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					RNF216	chr7	5620046	5781696	43469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	513
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67630	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67631	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67632	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67633	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67634	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67635	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67636	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67637	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67638	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TCTCTTCGCACTCTATGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67639	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67640	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67641	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67642	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67643	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67644	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67645	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67646	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67647	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				TACTGGCTGTAGCAGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67648	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67649	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67650	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67651	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67652	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67653	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67654	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67655	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67656	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				GTGGAGGTAGGGAGGTTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67657	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67658	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67659	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67660	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67661	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67662	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67663	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67664	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67665	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				ATTTCCAAGCCCACACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67666	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67667	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67668	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67669	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67670	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67671	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67672	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67673	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67674	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				CTAGCATAAGAAATGCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67675	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67676	hg19	N/A	enh23950	fant25510	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67677	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67678	hg19	N/A	enh23950	fant25511	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67679	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67680	hg19	N/A	enh23950	fant25512	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67681	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67682	hg19	N/A	enh23950	fant25513	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6291095	6300253	6251464	6260622	67683	hg19	N/A	enh23950	N/A	Enhatls157942	enhancer	E_840				AAGATCTTGCTACGTTGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67684	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67685	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67686	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67687	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67688	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67689	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				TTTGGGTCAGAAACGGTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67690	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67691	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67692	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67693	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67694	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67695	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				CTCGAGTGTACAGGACGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67696	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67697	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67698	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67699	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67700	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67701	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				AAGGGGGCGTCCGAAACGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67702	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67703	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67704	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67705	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67706	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67707	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GTGTCGCTCCTCTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67708	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67709	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67710	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67711	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67712	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67713	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				TCGCCGTTCGGCGCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67714	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67715	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67716	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67717	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67718	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67719	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GCCTGAGGCACGCCGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67720	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67721	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67722	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67723	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67724	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67725	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				AAGATGGATGAAGACGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67726	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67727	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67728	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67729	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67730	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67731	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				CCGGGCGGCTCCTCAGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67732	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67733	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67734	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67735	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67736	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67737	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GCGGGGCATGGGTCACGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67738	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67739	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67740	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67741	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67742	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67743	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				TCGGGAACCGGCCGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67744	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67745	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67746	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67747	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67748	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67749	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GCAGGCCGATCCGGTGTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67750	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67751	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67752	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67753	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67754	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67755	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GTGTGGCGTTCCAGTGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67756	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67757	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67758	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67759	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67760	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67761	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				GTGCAACTTGCACGTGCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67762	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67763	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67764	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67765	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67766	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67767	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				ATAACATAGCGACCCAGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67768	hg19	N/A	enh23951	fant25514	Enhatls157942	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67769	hg19	N/A	enh23951	N/A	Enhatls157942	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67770	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67771	hg19	N/A	N/A	fant25515	Enhatls157942	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147796	chr7	6310856	6313217	6271225	6273586	67772	hg19	N/A	N/A	N/A	Enhatls157942	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	608
enhrx-147797	chr7	6310856	6313217	6271225	6273586	67773	hg19	N/A	N/A	fant25516	N/A	enhancer	E_841				TCACGTCACTTGAGCCCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					CYTH3	chr7	6161778	6272624	669				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	609
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67774	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				AAGCACGCTGCGCTTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67775	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				AAGCACGCTGCGCTTCCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67776	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TTACAGTCATGGGCAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67777	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TTACAGTCATGGGCAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67778	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				GTAACGTTGGAGGCAGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67779	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				GTAACGTTGGAGGCAGTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67780	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				GTCTGTCTCCCTGGAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67781	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				GTCTGTCTCCCTGGAACGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67782	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				CGGGACAGTTCATCGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67783	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				CGGGACAGTTCATCGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67784	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TACCCTTTAGCACACTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67785	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TACCCTTTAGCACACTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67786	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TTGTTCTGTTTTTTTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67787	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TTGTTCTGTTTTTTTGAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67788	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				CACTACAGCATCAGCTTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67789	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				CACTACAGCATCAGCTTCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67790	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TCACTTTTGGCTGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					FAM220A	chr7	6329410	6348975	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147798	chr7	6356359	6359223	6316728	6319592	67791	hg19	N/A	enh39855	N/A	Enhatls157943	enhancer	E_842				TCACTTTTGGCTGGGCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					SMIM10L3	chr7	6329410	6348967	9104				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	610
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67792	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67793	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67794	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67795	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67796	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67797	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TTTGGGATGACCAGCAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67798	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67799	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67800	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67801	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67802	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67803	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				AGCTCATAGGAGCAATGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67804	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67805	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67806	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67807	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67808	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67809	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATAAAGGACTGAAATGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	indirect	Non Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67810	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67811	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67812	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67813	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67814	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67815	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				GCTGGTGATACAGTGAGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67816	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67817	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67818	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67819	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67820	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67821	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATGCTGGTGGTGAGGTGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67822	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67823	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67824	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67825	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67826	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67827	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				AGTGACAAAGGACTAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67828	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67829	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67830	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67831	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67832	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67833	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				ATGATTCATTGGTCAGAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67834	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67835	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67836	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67837	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67838	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67839	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				CACATCATCCTATGAAGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67840	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67841	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67842	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67843	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67844	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67845	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TGGAGACATTCTCAGATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67846	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67847	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67848	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67849	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67850	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67851	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				GAATAGGTGATCAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67852	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67853	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67854	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67855	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67856	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67857	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TTTTGGGAGACCGAGACGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67858	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67859	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67860	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67861	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67862	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67863	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				TACTTGGGGGTTGAGAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67864	hg19	N/A	enh23957	N/A	Enhatls157965	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67865	hg19	N/A	N/A	N/A	Enhatls157965	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67866	hg19	N/A	enh39856	N/A	Enhatls157965	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67867	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67868	hg19	N/A	enh39856	N/A	Enhatls157966	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-147817	chr7	6481573	6492165	6441942	6452534	67869	hg19	N/A	enh39856	N/A	N/A	enhancer	E_843				CCTCACAATGTAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	RAC1	direct	Highly Significant	NA					DAGLB	chr7	6409128	6484190	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	629
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67870	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67871	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67872	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67873	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67874	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67875	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67876	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				TCCAGCTGGGAATCAGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67877	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67878	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67879	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67880	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67881	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67882	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67883	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				GATTCAATGCTTGAAGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67884	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67885	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67886	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67887	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67888	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67889	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67890	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				GTGTGCTCTCAGTGGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67891	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67892	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67893	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67894	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67895	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67896	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67897	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				GTACAGAGTTCAGTGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67898	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67899	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67900	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67901	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67902	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67903	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67904	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				CAGTGCAGTTTGACTGTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67905	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67906	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67907	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67908	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67909	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67910	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67911	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				ATATGTTCACTCTGAAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67912	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67913	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67914	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67915	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67916	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67917	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67918	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				TTCCTACAGAGACTGTGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67919	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67920	hg19	N/A	enh39903	fant25627	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67921	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67922	hg19	N/A	enh39903	fant25628	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67923	hg19	N/A	enh39903	N/A	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148139	chr7	15593039	15603129	15553414	15563504	67924	hg19	N/A	N/A	N/A	Enhatls158310	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	951
enhrx-148140	chr7	15593039	15603129	15553414	15563504	67925	hg19	N/A	N/A	N/A	Enhatls158311	enhancer	E_846				GTCAGTAAGCACTGAATATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MEOX2	direct	Highly Significant	NA					AGMO	chr7	15200316	15562015	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	952
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67926	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAAAAGGTTCTGGTTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67927	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				TAAAAGGTTCTGGTTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67928	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAAAAGGTTCTGGTTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67929	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				TAAAAGGTTCTGGTTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67930	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAAAAGGTTCTGGTTGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67931	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGGACGCTTGAACTCATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67932	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				GGGACGCTTGAACTCATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67933	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGGACGCTTGAACTCATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67934	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				GGGACGCTTGAACTCATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67935	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGGACGCTTGAACTCATCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67936	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				AAAATGGCCACTTTTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67937	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				AAAATGGCCACTTTTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67938	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				AAAATGGCCACTTTTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67939	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				AAAATGGCCACTTTTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67940	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				AAAATGGCCACTTTTCTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67941	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CATTCCAAAACTATTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67942	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				CATTCCAAAACTATTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67943	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CATTCCAAAACTATTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67944	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				CATTCCAAAACTATTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67945	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CATTCCAAAACTATTCTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67946	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAATAGGGCCAGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67947	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				TAATAGGGCCAGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67948	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAATAGGGCCAGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67949	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				TAATAGGGCCAGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67950	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TAATAGGGCCAGGCTTCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67951	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TTCATCACGTAGTCACTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67952	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				TTCATCACGTAGTCACTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67953	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TTCATCACGTAGTCACTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67954	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				TTCATCACGTAGTCACTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67955	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				TTCATCACGTAGTCACTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67956	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGAGTGCGGCTGTCCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67957	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				GGAGTGCGGCTGTCCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67958	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGAGTGCGGCTGTCCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67959	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				GGAGTGCGGCTGTCCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67960	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				GGAGTGCGGCTGTCCTGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67961	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CCTCTTTCCCTGTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67962	hg19	N/A	enh9809	fant26578	Enhatls160351	enhancer	E_849				CCTCTTTCCCTGTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67963	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CCTCTTTCCCTGTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67964	hg19	N/A	enh9809	fant26579	Enhatls160351	enhancer	E_849				CCTCTTTCCCTGTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55130910	55134927	55063217	55067234	67965	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_849				CCTCTTTCCCTGTCAGCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67966	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				GATCATTCTTTAAATTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67967	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				CCCCTAGTCTGGAGAGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67968	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				CACATGGCTTAGCCTTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67969	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				TTCCTGCTCACTCTGAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67970	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				GGTCCAGGAGGAAATTCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67971	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				ATTAATGCTGCTCAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67972	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				ATGTAATCAAAATAGAATGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150009	chr7	55140122	55142213	55072429	55074520	67973	hg19	N/A	enh9809	N/A	Enhatls160351	enhancer	E_850				ATTCTCTCATTCAATGTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2821
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67974	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				GCATCATCTGCTTCATCAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67975	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				TTCCCAAAACCCAGCATCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67976	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				CAGAGCCACCAGGAGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67977	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				GCGCCTTTCCCTCCACCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67978	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				GTTGTCTATGCACAAACATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67979	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				CCGGATTTTCTCATTGTTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67980	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				GGGTGCGGCGGGTTCCGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67981	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				GCTCCTGAGCCTCCACACCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150032	chr7	55279867	55282528	55212174	55214835	67982	hg19	N/A	enh63681	N/A	Enhatls160378	enhancer	E_851				TCTGCAGATGAGACAAGCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					EGFR	chr7	55019016	55211628	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2844
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67983	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				GATCCTCTTGCCTCAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67984	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				GATCCTCTTGCCTCAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67985	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				GATCCTCTTGCCTCAGCCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67986	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				TGTACTATGGCCTGAACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67987	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				TGTACTATGGCCTGAACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67988	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				TGTACTATGGCCTGAACTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67989	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				GTGGCTGCTTCCACATTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67990	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				GTGGCTGCTTCCACATTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67991	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				GTGGCTGCTTCCACATTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67992	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				ATTGTGGTCCCCCCTCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67993	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				ATTGTGGTCCCCCCTCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67994	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				ATTGTGGTCCCCCCTCACCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67995	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				GCACGTTTGACACGTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67996	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				GCACGTTTGACACGTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67997	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				GCACGTTTGACACGTACATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67998	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				AAGAAAGAGGTCATTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	67999	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				AAGAAAGAGGTCATTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68000	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				AAGAAAGAGGTCATTCATGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68001	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				GTTTACGCTGTTCCGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68002	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				GTTTACGCTGTTCCGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68003	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				GTTTACGCTGTTCCGGAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68004	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				GCTCCCCTGGAAGGGTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68005	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				GCTCCCCTGGAAGGGTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68006	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				GCTCCCCTGGAAGGGTAAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68007	hg19	N/A	enh59773	N/A	Enhatls160401	enhancer	E_852				TGAGAAGCACCACACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94543				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68008	hg19	N/A	enh59773	N/A	N/A	enhancer	E_852				TGAGAAGCACCACACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	94393				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55763790	55767762	55696097	55700069	68009	hg19	N/A	enh59773	N/A	Enhatls160402	enhancer	E_852				TGAGAAGCACCACACAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	91975				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68010	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				TTTTGAGCAGAGCCAAGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68011	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				GTATCCACTTCCTAACCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68012	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				AAAACTTACTTAACCAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68013	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				CTCTCCTTCAGAAACTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68014	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				GGAACAACGGCCTCATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68015	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				TTTTCAGTAGTGCCAAGCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68016	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				ATGCACACCGGGCAGCATAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68017	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				GCCCCACTAGTTCTTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68018	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				TCGTGCAGAACCGGCCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68019	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				GGGCGGGGTTAGTTAGGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68020	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				ATCTTGGCCTCCCAAATGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150055	chr7	55841000	55843312	55773307	55775619	68021	hg19	N/A	enh59775	N/A	Enhatls160403	enhancer	E_853				TAAAAATACAAAATGTGGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					SEPTIN14	chr7	55793539	55862752	16225				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2867
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68022	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				TGCAGAACCAGCCGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68023	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				TGCAGAACCAGCCGAACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68024	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				GTCAGACAGTGAAAACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68025	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				GTCAGACAGTGAAAACCAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68026	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				ACCTTGAAAAGTGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68027	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				ACCTTGAAAAGTGCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68028	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				GGAACAACGGCCTCATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68029	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				GGAACAACGGCCTCATTGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68030	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				CTCTCCTTCAGAAACTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68031	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				CTCTCCTTCAGAAACTGATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68032	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				ATGTATCATTTAACCAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68033	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				ATGTATCATTTAACCAAATT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68034	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				TGGGGGGAGGGAAAGCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68035	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				TGGGGGGAGGGAAAGCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68036	hg19	N/A	enh56306	N/A	Enhatls160428	enhancer	E_854				GTTTTGAGCAGAGCCAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	942				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-150081	chr7	56072354	56078612	56004661	56010919	68037	hg19	N/A	N/A	N/A	Enhatls160428	enhancer	E_854				GTTTTGAGCAGAGCCAAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	EGFR	direct	Highly Significant	NA					PSPH	chr7	56011063	56051604	17				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2893
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68038	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				AAAATACAGCTATAAATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68039	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				ATCAGAAGAGCGCCATGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68040	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CTCTAACTCCATATCAAATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68041	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				ACTTGAGTTCTGTCATGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68042	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				ATCCTATTCATTCACCCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68043	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CATAGGTGCCATGAGCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68044	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				TGCCATCCCTGCATGTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68045	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CTTGTGCTCTCTGAAGTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68046	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GTCAGCTGTCCCAGAATGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68047	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GGGGGCAGGCCAAATTAGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68048	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CATCTGCTAGGACTACTGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68049	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				TGCTGGTGATACAAGCAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68050	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GGCATTCATCAGATGCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68051	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GCAGAGGTGGAGCAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68052	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GGTGCTCTGTCCTAGGGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68053	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GCAGGGCATCTCTGAAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68054	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				GCCGCCAGGAAATGTGAACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68055	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CTGGGGTCGACCTGGGACGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68056	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				TGGCTTCAGCCCCCTTTCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-151363	chr7	86946320	86949193	87317004	87319877	68057	hg19	N/A	enh24303	N/A	Enhatls161821	enhancer	E_856				CTGGTGTTCTAGGTGCCACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GRM3	direct	Highly Significant	NA					CROT	chr7	87345663	87399794	20325				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	4175
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68058	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68059	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68060	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68061	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68062	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68063	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68064	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68065	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68066	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				ATCATGTGGCCCAACTCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68067	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68068	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68069	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68070	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68071	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68072	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68073	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68074	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68075	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				CATGGGTTATTTTGGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68076	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68077	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68078	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68079	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68080	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68081	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68082	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68083	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68084	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				TCTATTCCTATAAAAATAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68085	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68086	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68087	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68088	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68089	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68090	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68091	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68092	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68093	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				CCTCCCCACCAAGAGATTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68094	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68095	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68096	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68097	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68098	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68099	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68100	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68101	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68102	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				CTAACAAGCACTCAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68103	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68104	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68105	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68106	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68107	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68108	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68109	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68110	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68111	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				GTCACGCTGGATGTCCGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68112	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68113	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68114	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68115	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68116	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68117	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68118	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68119	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68120	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				GGATCAAAAGGACGGAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68121	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68122	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68123	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68124	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68125	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68126	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68127	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68128	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68129	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				ATTGAAGTGAGTCACCAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68130	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68131	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68132	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68133	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68134	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68135	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68136	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68137	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68138	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				GAGCAGTGGACACGTGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68139	hg19	N/A	enh40436	N/A	Enhatls163114	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68140	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68141	hg19	N/A	enh40436	N/A	Enhatls163115	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68142	hg19	N/A	enh40436	N/A	N/A	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68143	hg19	N/A	enh40436	N/A	Enhatls163116	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152627	chr7	100778645	100786569	101135364	101143288	68144	hg19	N/A	N/A	N/A	Enhatls163116	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5439
enhrx-152628	chr7	100778645	100786569	101135364	101143288	68145	hg19	N/A	N/A	N/A	Enhatls163117	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5440
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68146	hg19	N/A	enh86684	N/A	N/A	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152629	chr7	100778645	100786569	101135364	101143288	68147	hg19	N/A	enh86684	N/A	Enhatls163118	enhancer	E_858				CAGAGGGTAGGGCACAAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					SERPINE1	chr7	101127103	101139247	23				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5441
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68148	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68149	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68150	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68151	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68152	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68153	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				CAATTCACAGCGACTTGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68154	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68155	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68156	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68157	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68158	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68159	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				GTGCGAGTTCCCTTGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68160	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68161	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68162	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68163	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68164	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68165	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				GTTCGGGCTCAGGACCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68166	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68167	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68168	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68169	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68170	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68171	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				CGGGGCGCATGCAAACACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68172	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68173	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68174	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68175	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68176	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68177	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				GGAAGGGCAGTCACGGGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68178	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68179	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68180	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68181	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68182	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68183	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				CCGGGATAGTGGCGCGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68184	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68185	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68186	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68187	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68188	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68189	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				TCCCCAACTACATCCGGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68190	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68191	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68192	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68193	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68194	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68195	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				CGAGCTGCCGGACTGGAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68196	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68197	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68198	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68199	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68200	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68201	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				TGCGGGGAGCGGACGTGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68202	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68203	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68204	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68205	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68206	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68207	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				CGTGGTCAGCATCATCGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68208	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68209	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68210	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68211	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68212	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68213	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				ATGAGGCTGTCGATCGTCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68214	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68215	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68216	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68217	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68218	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68219	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				AGGAGACGCCGGGCCACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68220	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68221	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68222	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68223	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68224	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68225	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				GAACGCGCTCCTGTTCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68226	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68227	hg19	N/A	enh116011	N/A	Enhatls163119	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68228	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68229	hg19	N/A	enh116011	N/A	Enhatls163120	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					AP1S1	chr7	101154475	101161276	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152630	chr7	100797710	100809613	101154429	101166332	68230	hg19	N/A	enh116011	N/A	N/A	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5442
enhrx-152631	chr7	100797710	100809613	101154429	101166332	68231	hg19	N/A	N/A	N/A	Enhatls163121	enhancer	E_859				GCGGAGCAGGAGAGACGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	STAG3	direct	Highly Significant	NA					VGF	chr7	101162508	101165569	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5443
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68232	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				TTGGTGAATTTTTAACTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68233	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				ATAGGTATTGGGAGAAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68234	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				CCATGGACGGCAGAATACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68235	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				GTGGCCTGTAGGGTGAGTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68236	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				TCCAGCAGTGTGTGCCTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68237	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				GAAAGATGAAAGCTAAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68238	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				ATTCTTGATTTAAGGTAGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115926532	115929230	116286478	116289176	68239	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_860				TCTGAGGTAGCTGGGACCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	17359				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68240	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68241	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68242	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68243	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68244	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68245	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68246	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GAAGAATCTGGTGGACGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68247	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68248	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68249	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68250	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68251	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68252	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68253	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AAGTTCTTGGGCTCACTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68254	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68255	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68256	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68257	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68258	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68259	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68260	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGAGAAACTGGACCGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68261	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68262	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68263	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68264	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68265	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68266	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68267	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TTGATGTGCTTTCTTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68268	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68269	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68270	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68271	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68272	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68273	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68274	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGACTGCAAGTCTTAATAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68275	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68276	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68277	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68278	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68279	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68280	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68281	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATATAAGCAGAATAGATTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68282	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68283	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68284	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68285	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68286	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68287	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68288	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				AGAATGCTCTGATTGCCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68289	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68290	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68291	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68292	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68293	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68294	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68295	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TGTCTGTCTTGTGACCTTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68296	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68297	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68298	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68299	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68300	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68301	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68302	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				TACACGTCTGATTCAGAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68303	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68304	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68305	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68306	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68307	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68308	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68309	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GATGTGGTGATTCATCAGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68310	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68311	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68312	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68313	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68314	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68315	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68316	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				ATAGAGCCTGTTTTTTAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68317	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	49599				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68318	hg19	N/A	N/A	fant27463	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56469				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68319	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	56788				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68320	hg19	N/A	N/A	fant27464	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58080				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68321	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58309				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68322	hg19	N/A	N/A	fant27465	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58434				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115953867	115958690	116313813	116318636	68323	hg19	N/A	N/A	N/A	Enhatls164040	enhancer	E_861				GTGACTACACAGATGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	58943				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68324	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				AGGTTCTAAATAATTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68325	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				GATATACTGAGGCCATTATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68326	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				AGTCTATAATTATTTACTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68327	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				TTGAAAGCATCCCGCATGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68328	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				TCAGCAATTCTCTCTGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68329	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				GGAAGTTGAGTCATTACAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68330	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				GCGGTCGTGTACTATGACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68331	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				CTTTTCATACATAAAGACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153513	chr7	115965941	115969365	116325887	116329311	68332	hg19	N/A	enh78290	N/A	Enhatls164040	enhancer	E_862				ACTGTGCATTTGGAAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					TES	chr7	116210538	116258783	64764				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6325
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68333	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				CTGCTGTGCTAGCAATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68334	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				CTGCTGTGCTAGCAATCAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68335	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				TTTCGGACCGGCTTAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68336	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				TTTCGGACCGGCTTAAAAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68337	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				GGGGTCAGGGATCAAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68338	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				GGGGTCAGGGATCAAAGAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68339	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				GCTTATCCACGGAGCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68340	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				GCTTATCCACGGAGCCAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68341	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				AGATAGATTCTGGATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68342	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				AGATAGATTCTGGATTTTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68343	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				GAGCAGCCTGTAGTGGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68344	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				GAGCAGCCTGTAGTGGTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68345	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				TGTCAGAACAAATCATTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68346	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				TGTCAGAACAAATCATTGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68347	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				TTTTTTTTACTCCTTGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68348	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				TTTTTTTTACTCCTTGGAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68349	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				TCTCTTCCAGCTCTACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68350	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				TCTCTTCCAGCTCTACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68351	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				GCACATTTTCTGCCTGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68352	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				GCACATTTTCTGCCTGTAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68353	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				TTCACATTACCTTCAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68354	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				TTCACATTACCTTCAGTGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68355	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				ATTTTACAAATATTAATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68356	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				ATTTTACAAATATTAATTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68357	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				AACACTAGGAACAAATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68358	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				AACACTAGGAACAAATGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68359	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				ATGAGCATGCCCATGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68360	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				ATGAGCATGCCCATGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68361	hg19	N/A	N/A	N/A	Enhatls164051	enhancer	E_864				CTTAGGCATCCCTAGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-153520	chr7	116364016	116365761	116723962	116725707	68362	hg19	N/A	enh84798	N/A	Enhatls164051	enhancer	E_864				CTTAGGCATCCCTAGAGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MET	direct	Highly Significant	NA					MET	chr7	116672195	116798377	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6332
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68363	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				TGGAGTCCTTCCCAGCATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68364	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				TGGAGTCCTTCCCAGCATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68365	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				TGGAGTCCTTCCCAGCATAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68366	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				TTAACCCCAGTCAGTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68367	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				TTAACCCCAGTCAGTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68368	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				TTAACCCCAGTCAGTAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68369	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				TCAATCTACATAAAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68370	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				TCAATCTACATAAAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68371	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				TCAATCTACATAAAGACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68372	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				ATTATCTTATGATCTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68373	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				ATTATCTTATGATCTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68374	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				ATTATCTTATGATCTTTTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68375	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				CAAGACAATGTGTGTCTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68376	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				CAAGACAATGTGTGTCTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68377	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				CAAGACAATGTGTGTCTTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68378	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				AAAACAGTAGTTCTGTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68379	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				AAAACAGTAGTTCTGTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68380	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				AAAACAGTAGTTCTGTTAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68381	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				TATTAACATGCACGGGGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68382	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				TATTAACATGCACGGGGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68383	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				TATTAACATGCACGGGGTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68384	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				AGGAATAACGAGGCGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68385	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				AGGAATAACGAGGCGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68386	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				AGGAATAACGAGGCGGTGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68387	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				AGTGTTCAATAGAACTAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68388	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				AGTGTTCAATAGAACTAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68389	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				AGTGTTCAATAGAACTAGTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68390	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				TGAGCTATATAGGAGTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68391	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				TGAGCTATATAGGAGTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68392	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				TGAGCTATATAGGAGTCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68393	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				GAAATAAAGCCAAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68394	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				GAAATAAAGCCAAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68395	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				GAAATAAAGCCAAAACACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68396	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				GCCAGTCGTGTAACCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68397	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				GCCAGTCGTGTAACCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68398	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				GCCAGTCGTGTAACCACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68399	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				ACTCTGGTCTTCCGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68400	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				ACTCTGGTCTTCCGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68401	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				ACTCTGGTCTTCCGGACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68402	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				AGGATAACCTGGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68403	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				AGGATAACCTGGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68404	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				AGGATAACCTGGTGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154914	chr7	140176936	140189923	140477136	140490123	68405	hg19	N/A	N/A	N/A	Enhatls165542	enhancer	E_866				AGAAGACAGCTCTGATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7726
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68406	hg19	N/A	N/A	N/A	Enhatls165543	enhancer	E_866				AGAAGACAGCTCTGATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	5066				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154915	chr7	140176936	140189923	140477136	140490123	68407	hg19	N/A	enh91828	N/A	Enhatls165543	enhancer	E_866				AGAAGACAGCTCTGATTCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					MKRN1	chr7	140453032	140479505	6901				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7727
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68408	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				TGGCAGAGCTGTGTGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68409	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				TGGCAGAGCTGTGTGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68410	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				TGGCAGAGCTGTGTGACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68411	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				CCAGCCTTGGAAAGGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68412	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				CCAGCCTTGGAAAGGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68413	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				CCAGCCTTGGAAAGGCTCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68414	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				TGGTTGACCTCGTCAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68415	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				TGGTTGACCTCGTCAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68416	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				TGGTTGACCTCGTCAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68417	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				GTTACTGTCACCAGGGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68418	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				GTTACTGTCACCAGGGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68419	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				GTTACTGTCACCAGGGCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68420	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				TTCATTACCTGTGGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68421	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				TTCATTACCTGTGGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68422	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				TTCATTACCTGTGGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68423	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				TCACCGCCTGGCTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68424	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				TCACCGCCTGGCTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68425	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				TCACCGCCTGGCTTTCACAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68426	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				TTTTAGGGTGTGGGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68427	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				TTTTAGGGTGTGGGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68428	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				TTTTAGGGTGTGGGCTACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68429	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				GCCTAACCGAGTCTGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68430	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				GCCTAACCGAGTCTGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68431	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				GCCTAACCGAGTCTGCAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68432	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				ATGAGACCTGGGACAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68433	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				ATGAGACCTGGGACAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68434	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				ATGAGACCTGGGACAGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68435	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				ATGGTCACCATAACAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68436	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				ATGGTCACCATAACAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68437	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				ATGGTCACCATAACAACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154919	chr7	140225413	140227519	140525613	140527719	68438	hg19	N/A	N/A	N/A	Enhatls165547	enhancer	E_867				GAGACCTGCCCAGGAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7731
enhrx-154920	chr7	140225413	140227519	140525613	140527719	68439	hg19	N/A	N/A	N/A	Enhatls165548	enhancer	E_867				GAGACCTGCCCAGGAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7732
enhrx-154921	chr7	140225413	140227519	140525613	140527719	68440	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_867				GAGACCTGCCCAGGAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68441	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CAGTGAGACACCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68442	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				CAGTGAGACACCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68443	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CAGTGAGACACCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68444	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				CAGTGAGACACCAGTCTCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68445	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CTCCCCCAGACTCCCTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68446	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				CTCCCCCAGACTCCCTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68447	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CTCCCCCAGACTCCCTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68448	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				CTCCCCCAGACTCCCTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68449	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CCTGAGAAGATGTCTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68450	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				CCTGAGAAGATGTCTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68451	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CCTGAGAAGATGTCTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68452	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				CCTGAGAAGATGTCTGGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68453	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GTCCCCCGGGAACGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68454	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GTCCCCCGGGAACGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68455	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GTCCCCCGGGAACGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68456	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GTCCCCCGGGAACGTGCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68457	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TGGCTTTCCACTTCTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68458	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				TGGCTTTCCACTTCTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68459	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TGGCTTTCCACTTCTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68460	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				TGGCTTTCCACTTCTAGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68461	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				AGAATTCCACCTCTAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68462	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				AGAATTCCACCTCTAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68463	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				AGAATTCCACCTCTAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68464	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				AGAATTCCACCTCTAGCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	indirect	Non Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68465	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GTGCTGATGAAATCCGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68466	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GTGCTGATGAAATCCGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68467	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GTGCTGATGAAATCCGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68468	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GTGCTGATGAAATCCGATCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68469	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GAGGAGCTCTCCAAGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68470	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GAGGAGCTCTCCAAGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68471	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GAGGAGCTCTCCAAGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68472	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GAGGAGCTCTCCAAGCTCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68473	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TAGCGAACTAAAACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68474	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				TAGCGAACTAAAACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68475	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TAGCGAACTAAAACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68476	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				TAGCGAACTAAAACACAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68477	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CGGCGCATGAGGGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68478	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				CGGCGCATGAGGGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68479	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CGGCGCATGAGGGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68480	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				CGGCGCATGAGGGGAGAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68481	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GGAAATCTGACTCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68482	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GGAAATCTGACTCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68483	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GGAAATCTGACTCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68484	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GGAAATCTGACTCTGAACTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68485	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TGCGGGGCCAGCCAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68486	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				TGCGGGGCCAGCCAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68487	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				TGCGGGGCCAGCCAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68488	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				TGCGGGGCCAGCCAACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68489	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				AATCAGAGCCTTCTTTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68490	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				AATCAGAGCCTTCTTTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68491	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				AATCAGAGCCTTCTTTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68492	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				AATCAGAGCCTTCTTTGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68493	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CAAAACAAAGAAGATCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68494	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				CAAAACAAAGAAGATCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68495	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				CAAAACAAAGAAGATCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68496	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				CAAAACAAAGAAGATCCGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68497	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GGACGGGGGTGGCCTCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68498	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GGACGGGGGTGGCCTCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68499	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GGACGGGGGTGGCCTCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68500	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GGACGGGGGTGGCCTCCTAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68501	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GAGGAGGGATGCCCTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68502	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				GAGGAGGGATGCCCTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68503	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				GAGGAGGGATGCCCTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68504	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				GAGGAGGGATGCCCTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68505	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				ACTAGGGCTGGCCCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68506	hg19	N/A	enh40673	fant27979	Enhatls165549	enhancer	E_868				ACTAGGGCTGGCCCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68507	hg19	N/A	enh40673	N/A	Enhatls165549	enhancer	E_868				ACTAGGGCTGGCCCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154921	chr7	140236832	140245750	140537032	140545950	68508	hg19	N/A	N/A	N/A	Enhatls165549	enhancer	E_868				ACTAGGGCTGGCCCAGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7733
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68509	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68510	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68511	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68512	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68513	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68514	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TTTCTTCCAGTCTTTTCTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68515	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68516	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68517	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68518	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68519	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68520	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TAACAGTGACGGTCTCTGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68521	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68522	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68523	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68524	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68525	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68526	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				AATGATTATTGTTTCCAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68527	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68528	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68529	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68530	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68531	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68532	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TAGGCCCCAAGGCAATGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68533	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68534	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68535	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68536	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68537	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68538	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				GTCAGTGTGAGCATACCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68539	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68540	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68541	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68542	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68543	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68544	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				GAGGTGTGATAGCTAGAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68545	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68546	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68547	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68548	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68549	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68550	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				ATTGTGGTGTTAGAGCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68551	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68552	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68553	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68554	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68555	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68556	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TAGATGCTGGGGTTATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68557	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68558	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68559	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68560	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68561	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68562	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				CCAGGCTCCTGCACCCTGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68563	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68564	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68565	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68566	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68567	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68568	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				GAGTCCAGACAGCAAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68569	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68570	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68571	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68572	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68573	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68574	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				ATCACACCAACCAAAAGACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68575	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68576	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68577	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68578	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68579	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68580	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TTGCAGAGTTAGTGGCAGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68581	hg19	N/A	enh40674	N/A	Enhatls165554	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154926	chr7	140262484	140268860	140562684	140569060	68582	hg19	N/A	N/A	N/A	Enhatls165554	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7738
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68583	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68584	hg19	N/A	N/A	fant27980	Enhatls165555	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154927	chr7	140262484	140268860	140562684	140569060	68585	hg19	N/A	N/A	N/A	Enhatls165555	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7739
enhrx-154928	chr7	140262484	140268860	140562684	140569060	68586	hg19	N/A	N/A	N/A	Enhatls165556	enhancer	E_869				TTCATTCTAGAGGTGAGTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7740
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68587	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TGGGTAACAAATGAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68588	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TGGGTAACAAATGAACAAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68589	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TCTGCCAACTGTGTGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68590	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TCTGCCAACTGTGTGTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68591	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				CTGGTGCTGAGTTGCTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68592	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				CTGGTGCTGAGTTGCTGGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68593	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				CTTGCCCATCCCGTCATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68594	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				CTTGCCCATCCCGTCATGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68595	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				CATCTGGCAGAGGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68596	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				CATCTGGCAGAGGGCCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68597	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TGGCTCATATGGAACAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68598	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TGGCTCATATGGAACAAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68599	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TGTCCTAGTGCCAGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68600	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TGTCCTAGTGCCAGTGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68601	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TGCCGTCATCGAGAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68602	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TGCCGTCATCGAGAGCACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68603	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				ACAGTTTCCCTATAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68604	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				ACAGTTTCCCTATAGTTCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68605	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				CTGTGTCGAATGCACAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68606	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				CTGTGTCGAATGCACAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68607	hg19	N/A	enh24588	N/A	N/A	enhancer	E_870				TGGAAGTTATTACTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140303959	140313060	140604159	140613260	68608	hg19	N/A	enh24588	N/A	Enhatls165561	enhancer	E_870				TGGAAGTTATTACTCCCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68609	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				ACAGCATGCATGGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68610	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				ACAGCATGCATGGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68611	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				ACAGCATGCATGGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68612	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				ACAGCATGCATGGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68613	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				ACAGCATGCATGGTGTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68614	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				AGGGCTGCCTCTGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68615	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				AGGGCTGCCTCTGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68616	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				AGGGCTGCCTCTGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68617	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				AGGGCTGCCTCTGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68618	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				AGGGCTGCCTCTGGAAGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68619	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CCAGGACAGATCACACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68620	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				CCAGGACAGATCACACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68621	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CCAGGACAGATCACACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68622	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				CCAGGACAGATCACACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68623	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CCAGGACAGATCACACCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68624	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CGGGTGCATTCCATTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68625	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				CGGGTGCATTCCATTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68626	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CGGGTGCATTCCATTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68627	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				CGGGTGCATTCCATTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68628	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				CGGGTGCATTCCATTCAAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68629	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GATTCTGCGGGTAGCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68630	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				GATTCTGCGGGTAGCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68631	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GATTCTGCGGGTAGCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68632	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				GATTCTGCGGGTAGCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68633	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GATTCTGCGGGTAGCACAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68634	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GAAGAGTCTGAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68635	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				GAAGAGTCTGAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68636	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GAAGAGTCTGAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68637	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				GAAGAGTCTGAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68638	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				GAAGAGTCTGAGGGGAGGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68639	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TGCCTTTTGTCCAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68640	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				TGCCTTTTGTCCAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68641	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TGCCTTTTGTCCAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68642	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				TGCCTTTTGTCCAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68643	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TGCCTTTTGTCCAAATGTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68644	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGGGGCCAGCACAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68645	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				TTGGGGCCAGCACAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68646	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGGGGCCAGCACAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68647	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				TTGGGGCCAGCACAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68648	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGGGGCCAGCACAAGAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68649	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGAGAGAGGGTTTATCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68650	hg19	N/A	enh24589	fant27981	Enhatls165561	enhancer	E_871				TTGAGAGAGGGTTTATCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68651	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGAGAGAGGGTTTATCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68652	hg19	N/A	enh24589	fant27982	Enhatls165561	enhancer	E_871				TTGAGAGAGGGTTTATCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140320400	140328199	140620600	140628399	68653	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_871				TTGAGAGAGGGTTTATCATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68654	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				TCAGGAATGTGACTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68655	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				TCAGGAATGTGACTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68656	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				TCAGGAATGTGACTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68657	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				TCAGGAATGTGACTTCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68658	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				CAGGGGCGTAAATTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68659	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				CAGGGGCGTAAATTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68660	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				CAGGGGCGTAAATTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68661	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				CAGGGGCGTAAATTGGGCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68662	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				TGAGGTCTGGCTCTACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68663	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				TGAGGTCTGGCTCTACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68664	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				TGAGGTCTGGCTCTACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68665	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				TGAGGTCTGGCTCTACTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68666	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				TTTGTCCCCAAGGGTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68667	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				TTTGTCCCCAAGGGTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68668	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				TTTGTCCCCAAGGGTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68669	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				TTTGTCCCCAAGGGTGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68670	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				TGACCGCTGTGAGGGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68671	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				TGACCGCTGTGAGGGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68672	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				TGACCGCTGTGAGGGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68673	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				TGACCGCTGTGAGGGGGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68674	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				CGGCTTTCTGCAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68675	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				CGGCTTTCTGCAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68676	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				CGGCTTTCTGCAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68677	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				CGGCTTTCTGCAGGTCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68678	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				TGCACAGTCCCGGGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68679	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				TGCACAGTCCCGGGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68680	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				TGCACAGTCCCGGGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68681	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				TGCACAGTCCCGGGACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68682	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GAGGGAGGAAACGGCTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68683	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GAGGGAGGAAACGGCTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68684	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GAGGGAGGAAACGGCTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68685	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GAGGGAGGAAACGGCTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68686	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GGGGGTGCAGGGTCGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68687	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GGGGGTGCAGGGTCGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68688	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GGGGGTGCAGGGTCGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68689	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GGGGGTGCAGGGTCGAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68690	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GGCGCATCTTGGGGGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68691	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GGCGCATCTTGGGGGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68692	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GGCGCATCTTGGGGGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68693	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GGCGCATCTTGGGGGCTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68694	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GGGAGGCTCGGCGGACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68695	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GGGAGGCTCGGCGGACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68696	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GGGAGGCTCGGCGGACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68697	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GGGAGGCTCGGCGGACAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68698	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				AAGCGCGCCGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68699	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				AAGCGCGCCGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68700	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				AAGCGCGCCGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68701	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				AAGCGCGCCGCTGGGGCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68702	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				CGCAGATCGTCGCGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68703	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				CGCAGATCGTCGCGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68704	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				CGCAGATCGTCGCGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68705	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				CGCAGATCGTCGCGGAGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68706	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GATTAGCTCACTGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68707	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GATTAGCTCACTGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68708	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GATTAGCTCACTGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68709	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GATTAGCTCACTGGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68710	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GTTTACCGCAGCTCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68711	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GTTTACCGCAGCTCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68712	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GTTTACCGCAGCTCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68713	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GTTTACCGCAGCTCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68714	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				GGTGGAATGGAGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68715	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				GGTGGAATGGAGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68716	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				GGTGGAATGGAGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68717	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				GGTGGAATGGAGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68718	hg19	N/A	enh24589	N/A	Enhatls165561	enhancer	E_872				CGTCCAAGCCTGGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68719	hg19	N/A	enh24589	fant27986	Enhatls165561	enhancer	E_872				CGTCCAAGCCTGGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68720	hg19	N/A	N/A	fant27986	Enhatls165561	enhancer	E_872				CGTCCAAGCCTGGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-154933	chr7	140339248	140341439	140639448	140641639	68721	hg19	N/A	N/A	N/A	Enhatls165561	enhancer	E_872				CGTCCAAGCCTGGGGAACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	BRAF	direct	Highly Significant	NA					DENND2A	chr7	140518419	140673993	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	7745
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68722	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GTGTAGGGTTGGGTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68723	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				GTGTAGGGTTGGGTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68724	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GTGTAGGGTTGGGTCCTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68725	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GGGCCATATGATCTTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68726	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				GGGCCATATGATCTTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68727	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GGGCCATATGATCTTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68728	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GATTGAATCCAGGCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68729	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				GATTGAATCCAGGCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68730	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GATTGAATCCAGGCTTTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68731	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACTCATTGTAGGCTTTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68732	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				ACTCATTGTAGGCTTTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68733	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACTCATTGTAGGCTTTTATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68734	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				TAGTGGTGACTAACATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68735	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				TAGTGGTGACTAACATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68736	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				TAGTGGTGACTAACATGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68737	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GTATGTACTGGGCAGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68738	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				GTATGTACTGGGCAGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68739	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GTATGTACTGGGCAGACAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68740	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				CTGCGGTTCAACACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68741	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				CTGCGGTTCAACACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68742	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				CTGCGGTTCAACACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68743	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACACAGGAATTGATGTTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68744	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				ACACAGGAATTGATGTTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68745	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACACAGGAATTGATGTTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68746	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ATTTCAGGAAAAACAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68747	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				ATTTCAGGAAAAACAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68748	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ATTTCAGGAAAAACAAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68749	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACAAAAAACTTTTGCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68750	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				ACAAAAAACTTTTGCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68751	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				ACAAAAAACTTTTGCTCTTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68752	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				TTCGGGAGCTCCACTGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68753	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				TTCGGGAGCTCCACTGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68754	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				TTCGGGAGCTCCACTGAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68755	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GGAGTTTTCAACTCTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	371120				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68756	hg19	N/A	enh25306	fant30930	Enhatls172621	enhancer	E_873				GGAGTTTTCAACTCTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	370748				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-161625	chr8	127963240	127964687	126950995	126952442	68757	hg19	N/A	enh25306	N/A	Enhatls172621	enhancer	E_873				GGAGTTTTCAACTCTTAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	MYC	direct	Highly Significant	NA					POU5F1B	chr8	127322182	127420066	366673				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	5416
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68758	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GCTGCGACGAGGGAGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68759	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GCTGCGACGAGGGAGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68760	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GCTGCGACGAGGGAGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68761	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GCTGCGACGAGGGAGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68762	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GCTGCGACGAGGGAGTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68763	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				CTCAGCCTACAGCGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68764	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				CTCAGCCTACAGCGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68765	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				CTCAGCCTACAGCGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68766	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				CTCAGCCTACAGCGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68767	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				CTCAGCCTACAGCGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68768	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				TACCTTTTCTCGGCCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68769	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				TACCTTTTCTCGGCCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68770	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				TACCTTTTCTCGGCCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68771	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				TACCTTTTCTCGGCCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68772	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				TACCTTTTCTCGGCCTAGTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68773	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GGAGGCAGACAACCTTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68774	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GGAGGCAGACAACCTTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68775	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GGAGGCAGACAACCTTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68776	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GGAGGCAGACAACCTTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68777	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GGAGGCAGACAACCTTGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68778	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GTGCAGCCCACGCCCACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68779	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GTGCAGCCCACGCCCACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68780	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GTGCAGCCCACGCCCACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68781	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GTGCAGCCCACGCCCACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68782	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GTGCAGCCCACGCCCACTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68783	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				TTGAGGGTGGCTGCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68784	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				TTGAGGGTGGCTGCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68785	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				TTGAGGGTGGCTGCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68786	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				TTGAGGGTGGCTGCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68787	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				TTGAGGGTGGCTGCGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68788	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GGCCCTGCGCAGGCGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68789	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GGCCCTGCGCAGGCGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68790	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GGCCCTGCGCAGGCGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68791	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GGCCCTGCGCAGGCGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68792	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GGCCCTGCGCAGGCGTCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68793	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				TCTGGGATCGAGGGGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68794	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				TCTGGGATCGAGGGGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68795	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				TCTGGGATCGAGGGGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68796	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				TCTGGGATCGAGGGGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68797	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				TCTGGGATCGAGGGGCATGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68798	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GGGTGCGCTCCGGCTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68799	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GGGTGCGCTCCGGCTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68800	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GGGTGCGCTCCGGCTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68801	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GGGTGCGCTCCGGCTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68802	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GGGTGCGCTCCGGCTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68803	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				GCAGCGTCCCGGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68804	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				GCAGCGTCCCGGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68805	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				GCAGCGTCCCGGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68806	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				GCAGCGTCCCGGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68807	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				GCAGCGTCCCGGGCACAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68808	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				TCCGGGGACCCGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68809	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				TCCGGGGACCCGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68810	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				TCCGGGGACCCGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68811	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				TCCGGGGACCCGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68812	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				TCCGGGGACCCGCCCGCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68813	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				AGCGCCGCGCGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68814	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				AGCGCCGCGCGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68815	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				AGCGCCGCGCGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68816	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				AGCGCCGCGCGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68817	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				AGCGCCGCGCGGGATGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68818	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				CGCGAGGTCTGCGTATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68819	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				CGCGAGGTCTGCGTATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68820	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				CGCGAGGTCTGCGTATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68821	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				CGCGAGGTCTGCGTATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68822	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				CGCGAGGTCTGCGTATTCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68823	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				CCGAGCCTGGGCGTACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68824	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				CCGAGCCTGGGCGTACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68825	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				CCGAGCCTGGGCGTACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68826	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				CCGAGCCTGGGCGTACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68827	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				CCGAGCCTGGGCGTACCCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68828	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				CGGGTTAAGAAGGATCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68829	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				CGGGTTAAGAAGGATCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68830	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				CGGGTTAAGAAGGATCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68831	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				CGGGTTAAGAAGGATCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68832	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				CGGGTTAAGAAGGATCACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68833	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				CTGGGCTCTGAGCTGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68834	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				CTGGGCTCTGAGCTGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68835	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				CTGGGCTCTGAGCTGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68836	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				CTGGGCTCTGAGCTGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68837	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				CTGGGCTCTGAGCTGAGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162389	chr8	144692655	144700753	143610485	143618583	68838	hg19	N/A	N/A	N/A	Enhatls173433	enhancer	E_876				TCGATGGAAGACGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6180
enhrx-162390	chr8	144692655	144700753	143610485	143618583	68839	hg19	N/A	N/A	N/A	Enhatls173434	enhancer	E_876				TCGATGGAAGACGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6181
enhrx-162391	chr8	144692655	144700753	143610485	143618583	68840	hg19	N/A	N/A	N/A	Enhatls173435	enhancer	E_876				TCGATGGAAGACGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6182
enhrx-162392	chr8	144692655	144700753	143610485	143618583	68841	hg19	N/A	N/A	N/A	Enhatls173436	enhancer	E_876				TCGATGGAAGACGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6183
enhrx-162393	chr8	144692655	144700753	143610485	143618583	68842	hg19	N/A	N/A	N/A	Enhatls173437	enhancer	E_876				TCGATGGAAGACGATGACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					GFUS	chr8	143612617	143618048	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6184
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68843	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GTGAGCCGGACTGGGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68844	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GTGAGCCGGACTGGGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68845	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GTGAGCCGGACTGGGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68846	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GTGAGCCGGACTGGGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68847	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GTGAGCCGGACTGGGGCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68848	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GGGGTTGGCATTGATTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68849	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GGGGTTGGCATTGATTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68850	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GGGGTTGGCATTGATTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68851	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GGGGTTGGCATTGATTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68852	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GGGGTTGGCATTGATTACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68853	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GCCGGCTGGGCGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68854	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GCCGGCTGGGCGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68855	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GCCGGCTGGGCGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68856	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GCCGGCTGGGCGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68857	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GCCGGCTGGGCGCCAGCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68858	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GTGCCTGGGGGACCAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68859	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GTGCCTGGGGGACCAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68860	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GTGCCTGGGGGACCAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68861	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GTGCCTGGGGGACCAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68862	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GTGCCTGGGGGACCAAGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68863	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				CCGCCTCCAGAGCATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68864	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				CCGCCTCCAGAGCATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68865	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				CCGCCTCCAGAGCATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68866	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				CCGCCTCCAGAGCATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68867	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				CCGCCTCCAGAGCATTCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68868	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				TCTGTTCGATGGCCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68869	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				TCTGTTCGATGGCCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68870	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				TCTGTTCGATGGCCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68871	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				TCTGTTCGATGGCCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68872	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				TCTGTTCGATGGCCCAGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68873	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GCCTGGGGCCGAAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68874	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GCCTGGGGCCGAAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68875	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GCCTGGGGCCGAAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68876	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GCCTGGGGCCGAAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68877	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GCCTGGGGCCGAAAAAAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68878	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				TTATTTAAATGAAAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68879	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				TTATTTAAATGAAAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68880	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				TTATTTAAATGAAAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68881	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				TTATTTAAATGAAAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68882	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				TTATTTAAATGAAAACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68883	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				ACTGCGAGTTCTGGGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68884	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				ACTGCGAGTTCTGGGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68885	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				ACTGCGAGTTCTGGGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68886	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				ACTGCGAGTTCTGGGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68887	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				ACTGCGAGTTCTGGGAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68888	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				AACGCGCGAGCTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68889	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				AACGCGCGAGCTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68890	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				AACGCGCGAGCTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68891	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				AACGCGCGAGCTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68892	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				AACGCGCGAGCTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68893	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GACAACTGCCCGCAGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68894	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GACAACTGCCCGCAGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68895	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GACAACTGCCCGCAGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68896	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GACAACTGCCCGCAGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68897	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GACAACTGCCCGCAGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68898	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GGGACGGGACCTGTAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68899	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GGGACGGGACCTGTAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68900	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GGGACGGGACCTGTAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68901	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GGGACGGGACCTGTAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68902	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GGGACGGGACCTGTAGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68903	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GGTGTGCGCCGTGGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68904	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GGTGTGCGCCGTGGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68905	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GGTGTGCGCCGTGGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68906	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GGTGTGCGCCGTGGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68907	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GGTGTGCGCCGTGGTCACGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68908	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GCGGACCCCAGCTTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68909	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GCGGACCCCAGCTTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68910	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GCGGACCCCAGCTTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68911	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GCGGACCCCAGCTTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68912	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GCGGACCCCAGCTTCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68913	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				TGAGGCCGCGAGCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68914	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				TGAGGCCGCGAGCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68915	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				TGAGGCCGCGAGCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68916	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				TGAGGCCGCGAGCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68917	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				TGAGGCCGCGAGCCGGCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68918	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				TCGTCGACCCAGCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68919	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				TCGTCGACCCAGCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68920	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				TCGTCGACCCAGCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68921	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				TCGTCGACCCAGCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68922	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				TCGTCGACCCAGCCTGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68923	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				CGACGGACGCAAGATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68924	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				CGACGGACGCAAGATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68925	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				CGACGGACGCAAGATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68926	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				CGACGGACGCAAGATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68927	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				CGACGGACGCAAGATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68928	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				ACCCAGATCGCGCGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68929	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				ACCCAGATCGCGCGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68930	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				ACCCAGATCGCGCGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68931	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				ACCCAGATCGCGCGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68932	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				ACCCAGATCGCGCGAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68933	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				CCTTCCGTCGCCCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68934	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				CCTTCCGTCGCCCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68935	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				CCTTCCGTCGCCCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68936	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				CCTTCCGTCGCCCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68937	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				CCTTCCGTCGCCCCTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68938	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GTCGGGCGTATCTCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68939	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GTCGGGCGTATCTCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68940	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GTCGGGCGTATCTCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68941	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GTCGGGCGTATCTCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68942	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GTCGGGCGTATCTCTCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68943	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				TCCAGAGGCTCTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68944	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				TCCAGAGGCTCTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68945	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				TCCAGAGGCTCTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68946	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				TCCAGAGGCTCTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68947	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				TCCAGAGGCTCTCCCCCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68948	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				CGACGTCAGCCTGAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68949	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				CGACGTCAGCCTGAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68950	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				CGACGTCAGCCTGAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68951	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				CGACGTCAGCCTGAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68952	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				CGACGTCAGCCTGAAACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68953	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				AACGGGGCCTCCCGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68954	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				AACGGGGCCTCCCGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68955	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				AACGGGGCCTCCCGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68956	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				AACGGGGCCTCCCGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68957	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				AACGGGGCCTCCCGGTCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-162455	chr8	144902500	144913169	143820330	143830999	68958	hg19	N/A	N/A	N/A	Enhatls173499	enhancer	E_877				GACTGATGTCAGCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6246
enhrx-162456	chr8	144902500	144913169	143820330	143830999	68959	hg19	N/A	N/A	N/A	Enhatls173500	enhancer	E_877				GACTGATGTCAGCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6247
enhrx-162457	chr8	144902500	144913169	143820330	143830999	68960	hg19	N/A	N/A	N/A	Enhatls173501	enhancer	E_877				GACTGATGTCAGCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6248
enhrx-162458	chr8	144902500	144913169	143820330	143830999	68961	hg19	N/A	N/A	N/A	Enhatls173502	enhancer	E_877				GACTGATGTCAGCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6249
enhrx-162459	chr8	144902500	144913169	143820330	143830999	68962	hg19	N/A	N/A	N/A	Enhatls173503	enhancer	E_877				GACTGATGTCAGCCAACCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PUF60	chr8	143816343	143830709	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6250
enhrx-lit838	chr8	144921919	144923354	143839747	143841182	68963	hg19					enhancer	E_878				GCTCGCCCTGGGACTCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit839	chr8	144921919	144923354	143839747	143841182	68964	hg19					enhancer	E_878				GGCTGATTCGCGGGCCGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit840	chr8	144921919	144923354	143839747	143841182	68965	hg19					enhancer	E_878				GTGACACCGCCCTCCCAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit841	chr8	144921919	144923354	143839747	143841182	68966	hg19					enhancer	E_878				CGCTTTTGCCAGCGACCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit842	chr8	144921919	144923354	143839747	143841182	68967	hg19					enhancer	E_878				GCGGATCGCGCAGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit843	chr8	144921919	144923354	143839747	143841182	68968	hg19					enhancer	E_878				AGCCCAGCCTAGAGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit844	chr8	144921919	144923354	143839747	143841182	68969	hg19					enhancer	E_878				TCCGGCAGGCACAGGCGGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit845	chr8	144921919	144923354	143839747	143841182	68970	hg19					enhancer	E_878				GACGAGGAGGAAACAGGGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit846	chr8	144921919	144923354	143839747	143841182	68971	hg19					enhancer	E_878				GCTTCGCGAAGGAGGCTTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit847	chr8	144921919	144923354	143839747	143841182	68972	hg19					enhancer	E_878				CGGGGGCGGGGACTAAAACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit848	chr8	144921919	144923354	143839747	143841182	68973	hg19					enhancer	E_878				GGCTTCGAGGAGGTGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit849	chr8	144921919	144923354	143839747	143841182	68974	hg19					enhancer	E_878				CGGAGCGCCCACTTCTCTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit850	chr8	144921919	144923354	143839747	143841182	68975	hg19					enhancer	E_878				CCAGCTGCAGAAGACCCCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-lit851	chr8	144921919	144923354	143839747	143841182	68976	hg19					enhancer	E_878				CGAAGGGGCACCGAGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA													CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	
enhrx-162483	chr8	145005248	145029385	143931080	143955217	68977	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	68978	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	68979	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	68980	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	68981	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	68982	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	68983	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	68984	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	68985	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	68986	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	68987	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	68988	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	68989	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	68990	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68991	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68992	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68993	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68994	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68995	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68996	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68997	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68998	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	68999	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69000	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69001	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69002	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69003	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69004	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69005	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69006	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69007	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69008	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69009	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69010	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69011	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69012	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TGGGGGTCGAGCTCCATCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69013	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69014	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69015	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69016	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69017	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69018	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69019	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69020	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69021	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69022	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69023	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69024	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69025	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69026	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69027	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69028	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69029	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69030	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69031	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69032	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69033	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69034	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69035	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69036	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69037	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69038	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69039	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69040	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69041	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69042	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69043	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69044	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69045	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69046	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69047	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69048	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				ATGCCACTGAGTGTAAAGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69049	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69050	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69051	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69052	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69053	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69054	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69055	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69056	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69057	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69058	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69059	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69060	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69061	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69062	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69063	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69064	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69065	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69066	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69067	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69068	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69069	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69070	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69071	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69072	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69073	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69074	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69075	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69076	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69077	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69078	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69079	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69080	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69081	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69082	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69083	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69084	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CACAAATCTGAGAGCTGAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69085	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69086	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69087	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69088	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69089	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69090	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69091	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69092	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69093	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69094	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69095	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69096	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69097	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69098	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69099	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69100	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69101	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69102	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69103	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69104	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69105	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69106	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69107	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69108	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69109	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69110	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69111	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69112	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69113	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69114	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69115	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69116	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69117	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69118	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69119	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69120	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCCTCCCTGTGGAGGAATGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69121	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69122	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69123	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69124	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69125	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69126	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69127	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69128	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69129	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69130	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69131	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69132	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69133	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69134	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69135	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69136	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69137	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69138	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69139	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69140	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69141	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69142	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69143	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69144	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69145	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69146	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69147	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69148	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69149	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69150	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69151	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69152	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69153	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69154	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69155	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69156	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				ATCCAGTCCAGGGTTGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69157	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69158	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69159	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69160	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69161	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69162	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69163	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69164	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69165	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69166	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69167	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69168	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69169	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69170	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69171	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69172	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69173	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69174	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69175	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69176	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69177	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69178	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69179	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69180	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69181	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69182	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69183	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69184	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69185	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69186	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69187	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69188	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69189	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69190	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69191	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69192	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GTTGATCCGCTTTCTGGCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69193	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69194	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69195	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69196	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69197	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69198	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69199	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69200	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69201	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69202	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69203	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69204	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69205	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69206	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69207	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69208	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69209	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69210	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69211	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69212	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69213	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69214	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69215	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69216	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69217	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69218	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69219	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69220	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69221	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69222	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69223	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69224	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69225	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69226	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69227	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69228	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGCTGCCTGTGTGCCACACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69229	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69230	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69231	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69232	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69233	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69234	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69235	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69236	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69237	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69238	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69239	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69240	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69241	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69242	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69243	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69244	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69245	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69246	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69247	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69248	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69249	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69250	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69251	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69252	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69253	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69254	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69255	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69256	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69257	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69258	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69259	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69260	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69261	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69262	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69263	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69264	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCCTGCTGTACTCCCCGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69265	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69266	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69267	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69268	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69269	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69270	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69271	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69272	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69273	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69274	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69275	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69276	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69277	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69278	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69279	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69280	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69281	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69282	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69283	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69284	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69285	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69286	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69287	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69288	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69289	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69290	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69291	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69292	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69293	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69294	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69295	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69296	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69297	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69298	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69299	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69300	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGGGAGGGGAGTGTCCCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69301	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69302	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69303	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69304	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69305	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69306	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69307	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69308	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69309	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69310	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69311	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69312	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69313	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69314	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69315	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69316	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69317	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69318	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69319	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69320	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69321	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69322	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69323	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69324	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69325	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69326	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69327	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69328	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69329	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69330	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69331	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69332	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69333	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69334	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69335	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69336	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCGCCAGAAACAGGAAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69337	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69338	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69339	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69340	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69341	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69342	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69343	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69344	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69345	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69346	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69347	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69348	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69349	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69350	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69351	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69352	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69353	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69354	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69355	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69356	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69357	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69358	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69359	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69360	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69361	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69362	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69363	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69364	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69365	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69366	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69367	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69368	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69369	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69370	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69371	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69372	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCACTTCACTGCACACCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69373	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69374	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69375	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69376	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69377	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69378	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69379	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69380	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69381	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69382	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69383	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69384	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69385	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69386	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69387	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69388	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69389	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69390	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69391	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69392	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69393	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69394	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69395	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69396	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69397	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69398	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69399	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69400	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69401	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69402	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69403	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69404	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69405	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69406	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69407	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69408	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGAGCTCCAAAGAGAGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69409	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69410	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69411	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69412	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69413	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69414	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69415	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69416	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69417	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69418	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69419	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69420	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69421	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69422	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69423	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69424	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69425	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69426	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69427	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69428	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69429	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69430	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69431	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69432	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69433	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69434	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69435	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69436	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69437	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69438	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69439	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69440	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69441	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69442	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69443	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69444	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AAGCCGCTGATACCTGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69445	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69446	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69447	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69448	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69449	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69450	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69451	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69452	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69453	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69454	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69455	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69456	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69457	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69458	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69459	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69460	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69461	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69462	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69463	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69464	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69465	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69466	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69467	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69468	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69469	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69470	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69471	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69472	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69473	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69474	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69475	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69476	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69477	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69478	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69479	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69480	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TCACAGACCTGCATGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69481	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69482	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69483	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69484	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69485	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69486	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69487	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69488	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69489	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69490	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69491	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69492	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69493	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69494	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69495	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69496	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69497	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69498	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69499	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69500	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69501	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69502	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69503	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69504	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69505	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69506	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69507	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69508	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69509	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69510	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69511	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69512	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69513	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69514	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69515	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69516	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGCCAGTGGGGTCCCACCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69517	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69518	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69519	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69520	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69521	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69522	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69523	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69524	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69525	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69526	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69527	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69528	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69529	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69530	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69531	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69532	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69533	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69534	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69535	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69536	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69537	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69538	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69539	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69540	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69541	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69542	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69543	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69544	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69545	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69546	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69547	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69548	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69549	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69550	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69551	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69552	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CGTCGGAGGCGCGTAGCTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69553	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69554	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69555	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69556	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69557	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69558	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69559	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69560	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69561	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69562	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69563	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69564	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69565	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69566	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69567	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69568	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69569	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69570	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69571	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69572	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69573	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69574	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69575	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69576	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69577	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69578	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69579	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69580	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69581	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69582	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69583	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69584	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69585	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69586	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69587	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69588	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				ATGGAGCATCGGGAAGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69589	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69590	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69591	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69592	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69593	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69594	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69595	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69596	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69597	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69598	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69599	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69600	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69601	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69602	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69603	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69604	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69605	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69606	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69607	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69608	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69609	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69610	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69611	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69612	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69613	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69614	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69615	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69616	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69617	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69618	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69619	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69620	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69621	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69622	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69623	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69624	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GACCTGGGCGACCCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69625	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69626	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69627	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69628	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69629	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69630	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69631	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69632	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69633	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69634	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69635	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69636	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69637	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69638	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69639	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69640	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69641	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69642	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69643	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69644	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69645	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69646	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69647	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69648	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69649	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69650	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69651	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69652	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69653	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69654	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69655	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69656	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69657	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69658	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69659	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69660	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGCTCCGCCCCGGACCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69661	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69662	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69663	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69664	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69665	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69666	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69667	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69668	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69669	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69670	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69671	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69672	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69673	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69674	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69675	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69676	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69677	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69678	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69679	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69680	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69681	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69682	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69683	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69684	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69685	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69686	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69687	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69688	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69689	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69690	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69691	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69692	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69693	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69694	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69695	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69696	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CTGGAACATTCTTGTGGTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69697	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69698	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69699	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69700	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69701	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69702	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69703	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69704	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69705	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69706	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69707	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69708	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69709	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69710	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69711	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69712	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69713	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69714	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69715	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69716	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69717	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69718	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69719	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69720	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69721	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69722	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69723	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69724	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69725	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69726	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69727	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69728	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69729	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69730	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69731	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69732	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCTCAGGGGCAGTAGGAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69733	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69734	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69735	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69736	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69737	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69738	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69739	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69740	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69741	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69742	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69743	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69744	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69745	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69746	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69747	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69748	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69749	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69750	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69751	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69752	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69753	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69754	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69755	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69756	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69757	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69758	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69759	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69760	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69761	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69762	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69763	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69764	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69765	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69766	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69767	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69768	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGCAAGTCCACAGAAGGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69769	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69770	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69771	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69772	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69773	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69774	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69775	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69776	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69777	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69778	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69779	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69780	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69781	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69782	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69783	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69784	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69785	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69786	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69787	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69788	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69789	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69790	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69791	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69792	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69793	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69794	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69795	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69796	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69797	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69798	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69799	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69800	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69801	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69802	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69803	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69804	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCTGGGTTTCCAGGACACGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69805	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69806	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69807	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69808	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69809	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69810	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69811	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69812	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69813	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69814	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69815	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69816	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69817	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69818	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69819	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69820	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69821	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69822	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69823	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69824	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69825	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69826	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69827	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69828	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69829	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69830	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69831	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69832	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69833	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69834	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69835	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69836	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69837	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69838	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69839	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69840	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCGAGCTCCGGAAACACCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69841	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69842	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69843	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69844	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69845	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69846	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69847	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69848	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69849	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69850	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69851	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69852	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69853	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69854	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69855	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69856	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69857	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69858	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69859	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69860	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69861	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69862	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69863	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69864	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69865	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69866	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69867	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69868	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69869	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69870	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69871	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69872	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69873	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69874	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69875	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69876	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TGGAAGCAGAGGCGCCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69877	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69878	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69879	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69880	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69881	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69882	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69883	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69884	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69885	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69886	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69887	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69888	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69889	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69890	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69891	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69892	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69893	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69894	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69895	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69896	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69897	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69898	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69899	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69900	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69901	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69902	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69903	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69904	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69905	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69906	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69907	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69908	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69909	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69910	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69911	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69912	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCAGTGGGCGGATTGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69913	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69914	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69915	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69916	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69917	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69918	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69919	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69920	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69921	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69922	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69923	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69924	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69925	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69926	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69927	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69928	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69929	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69930	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69931	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69932	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69933	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69934	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69935	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69936	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69937	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69938	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69939	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69940	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69941	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69942	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69943	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69944	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69945	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69946	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69947	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69948	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CGCGGCTTCCTGGCTGCGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69949	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69950	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69951	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69952	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69953	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69954	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69955	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69956	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69957	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69958	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69959	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69960	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69961	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69962	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69963	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69964	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69965	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69966	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69967	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69968	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69969	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69970	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69971	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69972	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69973	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69974	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69975	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	69976	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69977	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69978	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69979	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69980	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69981	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69982	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69983	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	69984	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGGCTGCCCTGGGACTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	69985	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	69986	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	69987	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	69988	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	69989	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	69990	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	69991	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	69992	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	69993	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	69994	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	69995	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	69996	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	69997	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	69998	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	69999	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70000	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70001	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70002	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70003	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70004	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70005	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70006	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70007	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70008	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70009	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70010	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70011	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70012	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70013	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70014	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70015	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70016	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70017	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70018	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70019	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70020	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAACGCTGGAGGCAGAACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70021	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70022	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70023	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70024	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70025	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70026	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70027	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70028	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70029	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70030	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70031	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70032	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70033	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70034	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70035	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70036	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70037	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70038	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70039	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70040	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70041	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70042	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70043	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70044	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70045	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70046	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70047	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70048	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70049	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70050	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70051	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70052	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70053	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70054	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70055	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70056	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CATCCTGTGAGCCAGGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70057	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70058	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70059	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70060	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70061	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70062	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70063	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70064	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70065	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70066	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70067	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70068	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70069	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70070	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70071	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70072	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70073	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70074	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70075	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70076	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70077	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70078	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70079	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70080	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70081	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70082	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70083	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70084	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70085	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70086	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70087	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70088	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70089	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70090	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70091	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70092	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCAGGATGGGACTTGGGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70093	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70094	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70095	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70096	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70097	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70098	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70099	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70100	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70101	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70102	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70103	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70104	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70105	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70106	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70107	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70108	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70109	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70110	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70111	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70112	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70113	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70114	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70115	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70116	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70117	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70118	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70119	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70120	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70121	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70122	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70123	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70124	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70125	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70126	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70127	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70128	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				ACTTGAGATGAGTCAAGATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70129	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70130	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70131	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70132	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70133	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70134	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70135	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70136	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70137	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70138	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70139	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70140	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70141	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70142	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70143	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70144	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70145	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70146	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70147	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70148	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70149	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70150	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70151	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70152	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70153	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70154	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70155	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70156	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70157	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70158	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70159	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70160	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70161	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70162	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70163	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70164	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGACTGCCTATCGGGGACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70165	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70166	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70167	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70168	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70169	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70170	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70171	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70172	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70173	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70174	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70175	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70176	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70177	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70178	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70179	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70180	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70181	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70182	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70183	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70184	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70185	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70186	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70187	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70188	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70189	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70190	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70191	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70192	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70193	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70194	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70195	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70196	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70197	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70198	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70199	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70200	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TTGAGGCTGCCCAATCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70201	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70202	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70203	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70204	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70205	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70206	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70207	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70208	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70209	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70210	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70211	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70212	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70213	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70214	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70215	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70216	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70217	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70218	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70219	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70220	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70221	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70222	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70223	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70224	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70225	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70226	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70227	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70228	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70229	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70230	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70231	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70232	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70233	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70234	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70235	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70236	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TCGGGCCGCACAGGGGGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70237	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70238	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70239	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70240	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70241	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70242	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70243	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70244	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70245	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70246	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70247	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70248	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70249	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70250	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70251	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70252	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70253	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70254	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70255	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70256	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70257	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70258	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70259	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70260	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70261	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70262	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70263	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70264	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70265	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70266	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70267	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70268	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70269	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70270	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70271	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70272	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGGAGCGTCCCCCACACGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70273	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70274	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70275	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70276	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70277	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70278	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70279	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70280	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70281	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70282	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70283	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70284	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70285	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70286	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70287	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70288	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70289	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70290	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70291	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70292	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70293	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70294	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70295	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70296	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70297	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70298	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70299	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70300	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70301	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70302	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70303	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70304	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70305	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70306	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70307	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70308	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCAGCCTGTGCGGGACAGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70309	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70310	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70311	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70312	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70313	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70314	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70315	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70316	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70317	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70318	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70319	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70320	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70321	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70322	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70323	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70324	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70325	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70326	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70327	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70328	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70329	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70330	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70331	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70332	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70333	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70334	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70335	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70336	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70337	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70338	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70339	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70340	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70341	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70342	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70343	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70344	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCTTTCACTGACATTCAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70345	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70346	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70347	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70348	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70349	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70350	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70351	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70352	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70353	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70354	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70355	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70356	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70357	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70358	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70359	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70360	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70361	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70362	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70363	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70364	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70365	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70366	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70367	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70368	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70369	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70370	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70371	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70372	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70373	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70374	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70375	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70376	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70377	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70378	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70379	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70380	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGACTCGAGGCGGGGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70381	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70382	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70383	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70384	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70385	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70386	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70387	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70388	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70389	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70390	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70391	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70392	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70393	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70394	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70395	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70396	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70397	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70398	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70399	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70400	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70401	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70402	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70403	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70404	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70405	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70406	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70407	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70408	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70409	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70410	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70411	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70412	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70413	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70414	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70415	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70416	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GAGGGGCAGCCCATCCAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70417	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70418	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70419	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70420	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70421	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70422	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70423	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70424	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70425	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70426	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70427	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70428	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70429	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70430	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70431	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70432	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70433	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70434	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70435	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70436	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70437	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70438	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70439	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70440	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70441	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70442	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70443	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70444	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70445	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70446	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70447	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70448	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70449	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70450	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70451	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70452	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CGTGGGTTGGCAGAAGGGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70453	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70454	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70455	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70456	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70457	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70458	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70459	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70460	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70461	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70462	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70463	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70464	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70465	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70466	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70467	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70468	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70469	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70470	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70471	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70472	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70473	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70474	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70475	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70476	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70477	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70478	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70479	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70480	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70481	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70482	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70483	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70484	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70485	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70486	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70487	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70488	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGTATCATCAGAACTGCCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70489	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70490	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70491	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70492	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70493	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70494	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70495	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70496	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70497	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70498	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70499	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70500	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70501	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70502	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70503	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70504	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70505	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70506	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70507	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70508	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70509	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70510	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70511	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70512	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70513	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70514	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70515	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70516	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70517	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70518	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70519	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70520	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70521	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70522	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70523	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70524	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGCTTGGGATGGGAAGCTAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70525	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70526	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70527	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70528	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70529	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70530	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70531	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70532	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70533	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70534	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70535	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70536	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70537	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70538	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70539	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70540	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70541	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70542	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70543	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70544	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70545	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70546	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70547	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70548	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70549	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70550	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70551	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70552	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70553	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70554	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70555	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70556	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70557	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70558	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70559	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70560	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGCTGTGGCTCGCTTCCTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70561	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70562	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70563	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70564	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70565	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70566	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70567	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70568	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70569	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70570	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70571	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70572	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70573	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70574	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70575	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70576	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70577	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70578	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70579	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70580	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70581	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70582	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70583	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70584	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70585	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70586	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70587	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70588	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70589	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70590	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70591	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70592	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70593	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70594	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70595	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70596	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GAGTCACCTCCATCGGGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70597	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70598	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70599	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70600	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70601	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70602	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70603	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70604	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70605	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70606	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70607	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70608	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70609	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70610	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70611	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70612	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70613	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70614	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70615	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70616	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70617	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70618	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70619	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70620	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70621	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70622	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70623	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70624	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70625	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70626	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70627	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70628	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70629	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70630	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70631	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70632	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CTGGCGGCAGGGCCAAGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70633	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70634	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70635	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70636	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70637	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70638	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70639	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70640	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70641	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70642	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70643	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70644	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70645	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70646	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70647	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70648	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70649	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70650	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70651	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70652	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70653	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70654	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70655	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70656	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70657	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70658	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70659	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70660	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70661	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70662	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70663	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70664	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70665	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70666	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70667	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70668	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCATGCTCAACTCCTAGCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70669	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70670	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70671	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70672	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70673	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70674	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70675	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70676	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70677	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70678	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70679	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70680	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70681	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70682	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70683	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70684	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70685	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70686	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70687	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70688	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70689	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70690	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70691	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70692	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70693	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70694	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70695	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70696	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70697	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70698	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70699	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70700	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70701	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70702	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70703	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70704	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGGCATGTAGTCCAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70705	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70706	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70707	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70708	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70709	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70710	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70711	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70712	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70713	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70714	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70715	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70716	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70717	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70718	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70719	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70720	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70721	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70722	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70723	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70724	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70725	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70726	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70727	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70728	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70729	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70730	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70731	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70732	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70733	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70734	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70735	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70736	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70737	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70738	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70739	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70740	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCACCCTGCAGCCATCCATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70741	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70742	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70743	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70744	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70745	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70746	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70747	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70748	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70749	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70750	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70751	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70752	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70753	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70754	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70755	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70756	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70757	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70758	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70759	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70760	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70761	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70762	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70763	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70764	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70765	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70766	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70767	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70768	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70769	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70770	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70771	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70772	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70773	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70774	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70775	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70776	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GACGGCCAGGGCCCAAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70777	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70778	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70779	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70780	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70781	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70782	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70783	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70784	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70785	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70786	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70787	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70788	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70789	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70790	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70791	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70792	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70793	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70794	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70795	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70796	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70797	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70798	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70799	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70800	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70801	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70802	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70803	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70804	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70805	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70806	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70807	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70808	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70809	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70810	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70811	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70812	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGTCCATGGAGCACAGCGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70813	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70814	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70815	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70816	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70817	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70818	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70819	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70820	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70821	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70822	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70823	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70824	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70825	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70826	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70827	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70828	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70829	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70830	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70831	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70832	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70833	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70834	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70835	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70836	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70837	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70838	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70839	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70840	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70841	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70842	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70843	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70844	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70845	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70846	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70847	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70848	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TTATAAATAGGGCGGTGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70849	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70850	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70851	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70852	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70853	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70854	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70855	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70856	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70857	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70858	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70859	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70860	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70861	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70862	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70863	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70864	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70865	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70866	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70867	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70868	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70869	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70870	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70871	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70872	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70873	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70874	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70875	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70876	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70877	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70878	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70879	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70880	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70881	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70882	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70883	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70884	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCACCGTGGCGCCATGGCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70885	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70886	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70887	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70888	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70889	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70890	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70891	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70892	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70893	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70894	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70895	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70896	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70897	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70898	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70899	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70900	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70901	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70902	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70903	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70904	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70905	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70906	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70907	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70908	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70909	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70910	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70911	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70912	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70913	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70914	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70915	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70916	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70917	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70918	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70919	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70920	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GCGCACGCCTGCGTACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70921	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70922	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70923	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70924	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70925	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70926	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70927	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70928	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70929	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70930	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70931	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70932	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70933	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70934	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70935	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70936	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70937	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70938	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70939	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70940	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70941	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70942	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70943	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70944	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70945	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70946	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70947	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70948	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70949	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70950	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70951	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70952	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70953	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70954	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70955	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70956	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TGGGGCTGGCTTCAGAGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70957	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70958	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70959	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70960	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70961	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70962	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70963	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	70964	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	70965	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	70966	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	70967	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	70968	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	70969	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	70970	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70971	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70972	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70973	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70974	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70975	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70976	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70977	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70978	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70979	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70980	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70981	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70982	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	70983	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	70984	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70985	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70986	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70987	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70988	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70989	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70990	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70991	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	70992	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGAAGATGTAGGGACCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	70993	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	70994	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	70995	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	70996	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	70997	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	70998	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	70999	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71000	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71001	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71002	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71003	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71004	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71005	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71006	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71007	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71008	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71009	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71010	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71011	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71012	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71013	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71014	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71015	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71016	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71017	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71018	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71019	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71020	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71021	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71022	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71023	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71024	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71025	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71026	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71027	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71028	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GTAGGGCCTTCTTTGGGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71029	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71030	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71031	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71032	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71033	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71034	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71035	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71036	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71037	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71038	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71039	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71040	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71041	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71042	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71043	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71044	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71045	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71046	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71047	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71048	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71049	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71050	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71051	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71052	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71053	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71054	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71055	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71056	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71057	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71058	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71059	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71060	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71061	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71062	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71063	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71064	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AATCCCCCCCAGATCTCCAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71065	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71066	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71067	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71068	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71069	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71070	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71071	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71072	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71073	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71074	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71075	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71076	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71077	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71078	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71079	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71080	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71081	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71082	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71083	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71084	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71085	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71086	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71087	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71088	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71089	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71090	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71091	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71092	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71093	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71094	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71095	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71096	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71097	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71098	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71099	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71100	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				TCTCCTACACAGGCCTGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71101	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71102	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71103	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71104	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71105	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71106	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71107	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71108	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71109	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71110	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71111	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71112	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71113	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71114	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71115	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71116	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71117	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71118	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71119	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71120	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71121	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71122	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71123	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71124	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71125	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71126	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71127	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71128	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71129	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71130	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71131	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71132	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71133	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71134	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71135	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71136	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCTCCAGCAGAGATGGGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71137	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71138	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71139	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71140	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71141	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71142	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71143	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71144	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71145	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71146	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71147	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71148	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71149	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71150	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71151	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71152	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71153	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71154	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71155	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71156	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71157	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71158	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71159	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71160	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71161	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71162	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71163	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71164	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71165	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71166	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71167	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71168	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71169	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71170	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71171	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71172	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CGGGAAGGGAAGCCGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71173	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71174	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71175	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71176	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71177	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71178	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71179	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71180	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71181	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71182	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71183	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71184	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71185	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71186	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71187	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71188	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71189	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71190	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71191	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71192	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71193	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71194	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71195	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71196	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71197	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71198	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71199	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71200	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71201	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71202	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71203	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71204	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71205	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71206	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71207	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71208	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGGGTGGCGCATGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71209	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71210	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71211	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71212	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71213	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71214	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71215	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71216	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71217	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71218	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71219	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71220	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71221	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71222	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71223	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71224	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71225	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71226	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71227	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71228	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71229	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71230	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71231	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71232	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71233	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71234	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71235	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71236	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71237	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71238	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71239	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71240	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71241	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71242	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71243	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71244	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GACGCCTGGACCCTGGCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71245	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71246	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71247	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71248	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71249	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71250	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71251	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71252	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71253	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71254	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71255	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71256	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71257	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71258	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71259	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71260	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71261	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71262	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71263	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71264	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71265	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71266	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71267	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71268	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71269	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71270	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71271	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71272	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71273	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71274	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71275	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71276	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71277	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71278	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71279	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71280	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CTTCGGTTCCCACAGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71281	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71282	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71283	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71284	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71285	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71286	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71287	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71288	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71289	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71290	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71291	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71292	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71293	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71294	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71295	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71296	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71297	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71298	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71299	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71300	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71301	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71302	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71303	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71304	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71305	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71306	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71307	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71308	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71309	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71310	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71311	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71312	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71313	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71314	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71315	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71316	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GTTTCCAGAGCAACCAGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71317	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71318	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71319	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71320	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71321	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71322	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71323	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71324	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71325	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71326	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71327	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71328	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71329	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71330	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71331	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71332	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71333	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71334	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71335	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71336	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71337	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71338	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71339	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71340	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71341	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71342	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71343	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71344	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71345	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71346	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71347	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71348	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71349	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71350	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71351	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71352	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCCTGAGCAAGTCCACACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71353	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71354	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71355	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71356	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71357	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71358	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71359	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71360	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71361	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71362	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71363	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71364	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71365	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71366	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71367	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71368	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71369	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71370	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71371	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71372	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71373	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71374	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71375	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71376	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71377	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71378	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71379	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71380	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71381	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71382	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71383	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71384	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71385	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71386	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71387	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71388	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CTTGGACGCCAGGTTGTGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71389	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71390	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71391	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71392	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71393	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71394	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71395	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71396	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71397	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71398	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71399	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71400	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71401	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71402	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71403	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71404	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71405	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71406	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71407	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71408	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71409	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71410	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71411	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71412	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71413	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71414	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71415	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71416	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71417	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71418	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71419	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71420	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71421	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71422	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71423	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71424	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				GGGCGGGGACAGGGACACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71425	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71426	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71427	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71428	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71429	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71430	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71431	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71432	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71433	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71434	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71435	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71436	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71437	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71438	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71439	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71440	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71441	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71442	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71443	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71444	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71445	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71446	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71447	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71448	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71449	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71450	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71451	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71452	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71453	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71454	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71455	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71456	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71457	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71458	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71459	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71460	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGTAGGACCCCGAACCAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71461	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71462	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71463	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71464	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71465	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71466	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71467	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71468	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71469	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71470	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71471	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71472	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71473	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71474	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71475	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71476	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71477	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71478	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71479	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71480	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71481	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71482	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71483	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71484	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71485	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71486	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71487	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71488	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71489	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71490	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71491	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71492	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71493	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71494	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71495	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71496	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CGTGGACTGCACCCAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71497	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71498	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71499	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71500	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71501	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71502	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71503	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71504	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71505	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71506	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71507	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71508	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71509	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71510	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71511	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71512	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71513	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71514	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71515	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71516	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71517	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71518	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71519	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71520	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71521	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71522	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71523	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71524	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71525	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71526	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71527	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71528	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71529	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71530	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71531	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71532	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				AGGGGTCCATGTCTGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71533	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71534	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71535	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71536	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71537	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71538	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71539	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71540	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71541	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71542	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71543	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71544	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71545	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71546	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71547	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71548	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71549	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71550	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71551	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71552	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71553	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71554	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71555	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71556	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71557	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71558	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71559	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71560	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71561	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71562	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71563	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71564	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71565	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71566	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71567	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71568	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCCGGCTGCGGCGCTGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71569	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71570	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71571	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71572	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71573	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71574	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71575	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71576	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71577	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71578	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71579	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71580	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71581	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71582	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71583	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71584	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71585	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71586	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71587	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71588	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71589	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71590	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71591	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71592	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71593	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71594	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71595	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71596	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71597	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71598	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71599	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71600	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71601	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71602	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71603	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71604	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CAGGGCTTGCCGGCCAGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162483	chr8	145005248	145029385	143931080	143955217	71605	hg19	N/A	N/A	N/A	Enhatls173526	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6274
enhrx-162484	chr8	145005248	145029385	143931080	143955217	71606	hg19	N/A	N/A	N/A	Enhatls173527	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6275
enhrx-162485	chr8	145005248	145029385	143931080	143955217	71607	hg19	N/A	N/A	N/A	Enhatls173528	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6276
enhrx-162486	chr8	145005248	145029385	143931080	143955217	71608	hg19	N/A	N/A	N/A	Enhatls173529	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6277
enhrx-162487	chr8	145005248	145029385	143931080	143955217	71609	hg19	N/A	N/A	N/A	Enhatls173530	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6278
enhrx-162488	chr8	145005248	145029385	143931080	143955217	71610	hg19	N/A	N/A	N/A	Enhatls173531	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6279
enhrx-162489	chr8	145005248	145029385	143931080	143955217	71611	hg19	N/A	N/A	N/A	Enhatls173532	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6280
enhrx-162490	chr8	145005248	145029385	143931080	143955217	71612	hg19	N/A	N/A	N/A	Enhatls173533	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6281
enhrx-162491	chr8	145005248	145029385	143931080	143955217	71613	hg19	N/A	N/A	N/A	Enhatls173534	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6282
enhrx-162492	chr8	145005248	145029385	143931080	143955217	71614	hg19	N/A	N/A	N/A	Enhatls173535	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6283
enhrx-162493	chr8	145005248	145029385	143931080	143955217	71615	hg19	N/A	N/A	N/A	Enhatls173536	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6284
enhrx-162494	chr8	145005248	145029385	143931080	143955217	71616	hg19	N/A	N/A	N/A	Enhatls173537	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6285
enhrx-162495	chr8	145005248	145029385	143931080	143955217	71617	hg19	N/A	N/A	N/A	Enhatls173538	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6286
enhrx-162496	chr8	145005248	145029385	143931080	143955217	71618	hg19	N/A	N/A	N/A	Enhatls173539	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6287
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71619	hg19	N/A	N/A	N/A	Enhatls173540	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71620	hg19	N/A	enh25403	N/A	Enhatls173540	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71621	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71622	hg19	N/A	enh25403	N/A	Enhatls173541	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71623	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71624	hg19	N/A	enh25403	N/A	Enhatls173542	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71625	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71626	hg19	N/A	enh25403	N/A	Enhatls173543	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71627	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71628	hg19	N/A	enh25403	N/A	Enhatls173544	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71629	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71630	hg19	N/A	enh25403	fant31592	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162497	chr8	145005248	145029385	143931080	143955217	71631	hg19	N/A	enh25403	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6288
enhrx-162498	chr8	145005248	145029385	143931080	143955217	71632	hg19	N/A	N/A	fant31593	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6289
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71633	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71634	hg19	N/A	enh10610	fant31594	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71635	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71636	hg19	N/A	enh10610	fant31595	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71637	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71638	hg19	N/A	enh10610	fant31596	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71639	hg19	N/A	enh10610	N/A	N/A	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162499	chr8	145005248	145029385	143931080	143955217	71640	hg19	N/A	enh10610	N/A	Enhatls173545	enhancer	E_879				CCGCCCCGGGCGCATGCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6290
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71641	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				ATAAATAGCTGCAGCCGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71642	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				TCTGCTGCAGCGAGGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71643	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GGGCGCGTACACCGGCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71644	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GCCCCCGTCCCCAAGAGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71645	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GCTGGCGCGGGGGCACAATG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71646	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GGGAGGCGCGGCTGACCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71647	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				TCTCGAGCGAGGGCAGGAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71648	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				CCACCAGGCATGTATGACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71649	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				CGCAGCCAGACTGCTCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71650	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				CCACCCAGAGCTGCGCCGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71651	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GGGCGATTCGGCCAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71652	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GCGGGGCCCGGAGCTCACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71653	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GATCCCCACTCCCCAAACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71654	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				GGGCGGGCGGTGTCGCCTCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71655	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				TGGCGGTCAGCAGCGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71656	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				CAGCTCAGGCGGCCACAGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162500	chr8	145048163	145052401	143973995	143978233	71657	hg19	N/A	N/A	fant31599	N/A	enhancer	E_880				TCCCCAGACACTTAACCGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					PLEC	chr8	143915152	143976734	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6291
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71658	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				GGCTTTGTGGAATAGAAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71659	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				GAGGCCAGAGTGCCTCTGCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71660	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				GGTGATTGTAGGGTTTTAAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71661	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				AGCAGGGAGACCCTAGCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71662	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				TGATGTTACTATAATTGTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71663	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				TGTCACATTTTGCTCATTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71664	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				CCTGTGTCCAGTGAGTCTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162581	chr8	145284485	145288047	144229582	144233144	71665	hg19	N/A	N/A	N/A	Enhatls173630	enhancer	E_881				CGCTTTACTGTACGTCACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MROH1	chr8	144148015	144261927	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6372
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71666	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				TGCATGGCATGCCCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71667	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GAGTGAGTAGCAGCAGCCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71668	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GGGAGACCTTCCCAGGGCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71669	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				TGACGCCCCTGACTGGGAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71670	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				TAGCACGGAGTGTTAAAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71671	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GCACGTGGATAATCCGGGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71672	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GCACTGCGCATTCCCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71673	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				AGTCGTGCCGGCCTCCGCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71674	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				AGCCTCGCCCACCGCCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71675	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				AGACGCTAAGCGGCGCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71676	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GTGAGGACTCTCCCGGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71677	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GGGTCTCTAGGGCGGGGTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71678	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GAGGATCGCCTGAGTCCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71679	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GACTCTGTTTAGCAGAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71680	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				TCCCGGTGCAGGCGGCGTCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71681	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				GCGCGATCTCCAGAGGGCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162618	chr8	145595607	145600020	144371940	144376331	71682	hg19	N/A	N/A	N/A	Enhatls173678	enhancer	E_882				AGGCGAGCGAAGGAGGTCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					ADCK5	chr8	144374046	144393242	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6409
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71683	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71684	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71685	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71686	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71687	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71688	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71689	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71690	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71691	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GGCAGTAAGATAAACTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71692	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71693	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71694	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71695	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71696	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71697	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71698	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71699	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71700	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GGGAGTGGACGGTGCTACCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71701	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71702	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71703	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71704	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71705	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71706	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71707	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71708	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71709	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CCGCCCGCGCCGAAGCCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71710	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71711	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71712	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71713	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71714	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71715	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71716	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71717	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71718	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				ACGTTCCCTACCTACATGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71719	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71720	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71721	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71722	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71723	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71724	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71725	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71726	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71727	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GTCGAGGCCATTGCGAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71728	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71729	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71730	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71731	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71732	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71733	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71734	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71735	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71736	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CTTCTGCCTAACAGCGAAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71737	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71738	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71739	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71740	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71741	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71742	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71743	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71744	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71745	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				TGCTCGTTGTCCACTCTGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71746	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71747	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71748	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71749	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71750	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71751	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71752	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71753	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71754	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CCGAAGCTGTGCCGGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71755	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71756	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71757	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71758	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71759	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71760	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71761	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71762	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71763	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CGGTCGGGAAGATGGCGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71764	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71765	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71766	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71767	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71768	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71769	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71770	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71771	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71772	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GGGGTCGCCCCGACGCGCGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71773	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71774	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71775	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71776	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71777	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71778	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71779	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71780	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71781	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GAATGTCCCGAAGTCCGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71782	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71783	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71784	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71785	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71786	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71787	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71788	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71789	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71790	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CCGCCTGCCAGGCAGCCACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71791	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71792	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71793	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71794	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71795	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71796	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71797	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71798	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71799	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				TTAGGGGCTTCGGTGAGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71800	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71801	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71802	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71803	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71804	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71805	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71806	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71807	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71808	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GGCGAGTGCACGCTGGACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71809	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71810	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71811	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71812	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71813	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71814	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71815	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71816	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71817	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				ACGCCTCTGCGCTGAGGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71818	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71819	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71820	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71821	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71822	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71823	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71824	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71825	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71826	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CTATCTTGTCCCACAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71827	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71828	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71829	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71830	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71831	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71832	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71833	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71834	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71835	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CGGCGGCGTCCTGGTGCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71836	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71837	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71838	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71839	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71840	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71841	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71842	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71843	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71844	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				CGCTTTCGCTGAGGGCCCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71845	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71846	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71847	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71848	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71849	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71850	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71851	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71852	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71853	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GGGATCATCTGCACAGCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162641	chr8	145647857	145656949	144422474	144431566	71854	hg19	N/A	N/A	N/A	Enhatls173703	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	4				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6432
enhrx-162642	chr8	145647857	145656949	144422474	144431566	71855	hg19	N/A	N/A	N/A	Enhatls173704	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6433
enhrx-162643	chr8	145647857	145656949	144422474	144431566	71856	hg19	N/A	N/A	N/A	Enhatls173705	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6434
enhrx-162644	chr8	145647857	145656949	144422474	144431566	71857	hg19	N/A	N/A	N/A	Enhatls173706	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6435
enhrx-162645	chr8	145647857	145656949	144422474	144431566	71858	hg19	N/A	N/A	N/A	Enhatls173707	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6436
enhrx-162646	chr8	145647857	145656949	144422474	144431566	71859	hg19	N/A	N/A	N/A	Enhatls173708	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6437
enhrx-162647	chr8	145647857	145656949	144422474	144431566	71860	hg19	N/A	N/A	N/A	Enhatls173709	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6438
enhrx-162648	chr8	145647857	145656949	144422474	144431566	71861	hg19	N/A	N/A	N/A	Enhatls173710	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6439
enhrx-162649	chr8	145647857	145656949	144422474	144431566	71862	hg19	N/A	N/A	N/A	Enhatls173711	enhancer	E_883				GTAGGCATGGACTTTGAGAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					VPS28	chr8	144423600	144428563	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6440
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71863	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71864	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71865	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71866	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71867	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71868	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71869	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71870	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71871	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71872	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71873	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				TCCTGGTGTCAGCCGAAGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71874	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71875	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71876	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71877	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71878	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71879	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71880	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71881	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71882	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71883	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71884	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GGATCCGAAACTACTGAGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71885	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71886	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71887	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71888	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71889	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71890	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71891	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71892	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71893	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71894	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71895	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GTGGGAGCGCGCACGTGGCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71896	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71897	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71898	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71899	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71900	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71901	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71902	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71903	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71904	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71905	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71906	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				ACGGCGTCGCTGGAGCCCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71907	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71908	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71909	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71910	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71911	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71912	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71913	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71914	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71915	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71916	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71917	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CAGTGCTGGGCGCGGGCCGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71918	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71919	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71920	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71921	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71922	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71923	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71924	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71925	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71926	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71927	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71928	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CTCTGCGATACCGCAGGTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71929	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71930	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71931	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71932	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71933	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71934	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71935	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71936	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71937	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71938	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71939	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GCGAGCGGTCCGGACACCGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71940	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71941	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71942	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71943	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71944	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71945	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71946	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71947	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71948	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71949	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71950	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GGGCAGAGTCAGCGTCGTAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	indirect	Non Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71951	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71952	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71953	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71954	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71955	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71956	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71957	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71958	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71959	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71960	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71961	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GTTCCAGGTGGGGTCCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71962	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71963	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71964	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71965	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71966	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71967	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71968	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71969	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71970	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71971	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71972	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				AGGCCGGACTGGAGCCCGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71973	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71974	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71975	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71976	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71977	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71978	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71979	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71980	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71981	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71982	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71983	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GCCCCACGCGCGTCAGCGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71984	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71985	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71986	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71987	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71988	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	71989	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	71990	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	71991	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	71992	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	71993	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	71994	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GCTGGCTTGGGCCCCGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	71995	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	71996	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	71997	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	71998	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	71999	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72000	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72001	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72002	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72003	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72004	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72005	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				ACGCGCAGCACGGCGGGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72006	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72007	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72008	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72009	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72010	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72011	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72012	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72013	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72014	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72015	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72016	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				AGCAACCCCGCCACAGCGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72017	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72018	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72019	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72020	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72021	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72022	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72023	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72024	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72025	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72026	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72027	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				TGCTGGAGCCGGCCGAACTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72028	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72029	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72030	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72031	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72032	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72033	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72034	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72035	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72036	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72037	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72038	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CTGGGGGCCGCGCTAGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72039	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72040	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72041	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72042	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72043	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72044	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72045	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72046	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72047	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72048	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72049	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CTGCTGTGGGAGCCGCCGCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72050	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72051	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72052	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72053	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72054	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72055	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72056	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72057	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72058	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72059	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72060	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CCACACCGCGCACCTTCTGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72061	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72062	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72063	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72064	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72065	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72066	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72067	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72068	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72069	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72070	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72071	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				TTTGTGCTCACCTACAAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72072	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72073	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72074	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72075	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72076	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72077	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72078	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72079	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72080	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72081	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72082	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GGGGCTTGCAACCCATTACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72083	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72084	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72085	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72086	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72087	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72088	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72089	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72090	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72091	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72092	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72093	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				CTGGGGGCGGACAAGACACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-162674	chr8	145732562	145738179	144507179	144512796	72094	hg19	N/A	N/A	N/A	Enhatls173736	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6465
enhrx-162675	chr8	145732562	145738179	144507179	144512796	72095	hg19	N/A	N/A	N/A	Enhatls173737	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6466
enhrx-162676	chr8	145732562	145738179	144507179	144512796	72096	hg19	N/A	N/A	N/A	Enhatls173738	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6467
enhrx-162677	chr8	145732562	145738179	144507179	144512796	72097	hg19	N/A	N/A	N/A	Enhatls173739	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6468
enhrx-162678	chr8	145732562	145738179	144507179	144512796	72098	hg19	N/A	N/A	N/A	Enhatls173740	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					MFSD3	chr8	144509069	144511213	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6469
enhrx-162679	chr8	145732562	145738179	144507179	144512796	72099	hg19	N/A	N/A	N/A	Enhatls173741	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6470
enhrx-162680	chr8	145732562	145738179	144507179	144512796	72100	hg19	N/A	N/A	N/A	Enhatls173742	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6471
enhrx-162681	chr8	145732562	145738179	144507179	144512796	72101	hg19	N/A	N/A	N/A	Enhatls173743	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6472
enhrx-162682	chr8	145732562	145738179	144507179	144512796	72102	hg19	N/A	N/A	N/A	Enhatls173744	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6473
enhrx-162683	chr8	145732562	145738179	144507179	144512796	72103	hg19	N/A	N/A	N/A	Enhatls173745	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6474
enhrx-162684	chr8	145732562	145738179	144507179	144512796	72104	hg19	N/A	N/A	N/A	Enhatls173746	enhancer	E_884				GTTCCAGAGCTGCAGATACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	VPS28	direct	Highly Significant	NA					RECQL4	chr8	144511287	144517845	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	6475
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72105	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AAGGACAGAGTACTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72106	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				AAGGACAGAGTACTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72107	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AAGGACAGAGTACTGGCTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72108	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AGTCAAGTCCAGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72109	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				AGTCAAGTCCAGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72110	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AGTCAAGTCCAGACTCCCAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72111	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AGTAAAGGGAGATCTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72112	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				AGTAAAGGGAGATCTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72113	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				AGTAAAGGGAGATCTCTGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72114	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				GAAATAATTTATACATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72115	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				GAAATAATTTATACATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72116	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				GAAATAATTTATACATAGCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72117	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TAAAGCTATTAAATAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72118	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				TAAAGCTATTAAATAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72119	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TAAAGCTATTAAATAAACCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72120	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TTCCAGAAAGAGTCATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72121	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				TTCCAGAAAGAGTCATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72122	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TTCCAGAAAGAGTCATCAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72123	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				GTCAGGCCTGGGTATGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72124	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				GTCAGGCCTGGGTATGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72125	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				GTCAGGCCTGGGTATGTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72126	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TTGGTAACTTTTAAGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72127	hg19	N/A	enh25513	fant32071	Enhatls174889	enhancer	E_887				TTGGTAACTTTTAAGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-163779	chr9	27154140	27155859	27154142	27155861	72128	hg19	N/A	enh25513	N/A	Enhatls174889	enhancer	E_887				TTGGTAACTTTTAAGATCTC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	"C9orf72,MOB3B,IFNK"	direct	Highly Significant	NA					TEK	chr9	27109140	27230174	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	1046
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72129	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				TTATAAGGCTATATACATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72130	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				GTGCATGCTTTTTCTTTAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72131	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				AGACAACTACAAGTATGCAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72132	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				AAAGATTCTGATACAACTGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72133	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				ACTCATAACAAGATACCCTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72134	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				AATGGTGTCATCAAGGTATC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72135	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				AGTCAGTTTGCAGTCAGGAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72136	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				GGGTGTCTCCATTTTTATTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165492	chr9	81589205	81590243	78974289	78975327	72137	hg19	N/A	enh25624	N/A	Enhatls177100	enhancer	E_889				CCTTATCCAATTCCTGACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	GNAQ	direct	Highly Significant	NA					TLE4	chr9	79571772	79726882	595134				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2759
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72138	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				CCCTTTTCTCTATCTCTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72139	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				CCCTTTTCTCTATCTCTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72140	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				CCCTTTTCTCTATCTCTTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72141	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				AGACCTGGACAGAACTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72142	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				AGACCTGGACAGAACTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72143	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				AGACCTGGACAGAACTGTAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72144	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGAATCTTGCTAAGAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72145	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				TGAATCTTGCTAAGAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72146	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGAATCTTGCTAAGAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72147	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TCTGATGTGGATGGGATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72148	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				TCTGATGTGGATGGGATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72149	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TCTGATGTGGATGGGATCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72150	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGGAGGCTACGGGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72151	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				TGGAGGCTACGGGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72152	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGGAGGCTACGGGACACAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72153	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				GGTGGATGACTACGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72154	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				GGTGGATGACTACGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72155	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				GGTGGATGACTACGTAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72156	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGGTGAGTAGGTCATTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72157	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				TGGTGAGTAGGTCATTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72158	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TGGTGAGTAGGTCATTGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72159	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TTGACTTGCACAATAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72160	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				TTGACTTGCACAATAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72161	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				TTGACTTGCACAATAATAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72162	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				GACATCAGTCCATTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	194199				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72163	hg19	N/A	enh25639	fant32549	Enhatls177133	enhancer	E_890				GACATCAGTCCATTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	193831				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84003865	84006348	81388950	81391433	72164	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_890				GACATCAGTCCATTGTGATA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	189082				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72165	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GTAGCTTGTAGAAATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72166	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GTAGCTTGTAGAAATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72167	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GTAGCTTGTAGAAATGGTTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72168	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GTGCTTAAAGAGCATTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72169	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GTGCTTAAAGAGCATTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72170	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GTGCTTAAAGAGCATTCACC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72171	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				CAATTGACTCCATTGTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72172	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				CAATTGACTCCATTGTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72173	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				CAATTGACTCCATTGTTTTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72174	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GGCTTAGATCTTCTAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72175	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GGCTTAGATCTTCTAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72176	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GGCTTAGATCTTCTAACCCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72177	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GCTAGGCCTTTCTATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72178	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GCTAGGCCTTTCTATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72179	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GCTAGGCCTTTCTATCAGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72180	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TGGGTGGAGGGGATGCGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72181	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TGGGTGGAGGGGATGCGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72182	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TGGGTGGAGGGGATGCGGTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72183	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TCTTGCATCTGATTTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72184	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TCTTGCATCTGATTTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72185	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TCTTGCATCTGATTTAAAGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72186	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GATCTATTTAGAATGAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72187	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GATCTATTTAGAATGAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72188	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GATCTATTTAGAATGAAACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72189	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TGATGAATGCCGCATTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72190	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TGATGAATGCCGCATTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72191	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TGATGAATGCCGCATTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72192	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TTTATTTTAAGTCTCTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72193	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TTTATTTTAAGTCTCTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72194	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TTTATTTTAAGTCTCTGACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72195	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TGCTACGGAACCACGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72196	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TGCTACGGAACCACGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72197	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TGCTACGGAACCACGTACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72198	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TGGGTGAAGCCAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72199	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TGGGTGAAGCCAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72200	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TGGGTGAAGCCAATAGAAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72201	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				GGAACATGTCTATGGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72202	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				GGAACATGTCTATGGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72203	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				GGAACATGTCTATGGAAAAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72204	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				CCTCTTGCTCAAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72205	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				CCTCTTGCTCAAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72206	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				CCTCTTGCTCAAGGAAGCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72207	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				AAAGAAGGCAAGCTATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72208	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				AAAGAAGGCAAGCTATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72209	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				AAAGAAGGCAAGCTATTCTA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72210	hg19	hs722	enh25639	N/A	Enhatls177133	enhancer	E_891				TCGTCCCATGTAGATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	187732				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72211	hg19	N/A	enh25639	N/A	Enhatls177133	enhancer	E_891				TCGTCCCATGTAGATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	184883				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-165522	chr9	84009636	84016015	81394721	81401100	72212	hg19	N/A	N/A	N/A	Enhatls177133	enhancer	E_891				TCGTCCCATGTAGATAGACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	TLE1	direct	Highly Significant	NA					TLE1	chr9	81583682	81689547	175509				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	2789
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72213	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				CATTAACACTGGACTCTACT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72214	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				GTGAAACAAGTGGATGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72215	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				GCAAAAGCCTCTTCAGCGTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72216	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				TCTGTTTCTCAGCCCCTAGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72217	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				GTTTGGATACCCACAGACAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72218	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				GTAAAGTTCATACACAGAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72219	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				CTTTCAGATCCATTACTCAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72220	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				GGAGAGACCACTTCATACAT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166561	chr9	101302234	101303250	98539952	98540968	72221	hg19	N/A	enh25811	N/A	Enhatls178273	enhancer	E_893				CAGGGGGCAAGAACCTCAGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3828
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72222	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TTGCTGTGTTTGAGAGGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72223	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TTTAACCAGCAGCATGGGGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72224	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				AACGCTCATGAAACATATCA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72225	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GGTGAGCTCATGCAGCTACG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72226	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				CCCTGTGACTGAGAGAACAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72227	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TCGCGAAGCATAGATTTTTG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72228	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GGAGTTTCTTGGTCTTGTGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72229	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TCTGGGTTCGTATCTGCAAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72230	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GCAAGAATTCGTCAATGCCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72231	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GCAGGTATAACCGGGCAGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72232	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				AGAAACAGTCAGCAAAGTCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72233	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TTCCTTTCAGCTGAGATGAA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72234	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GACCTGGCGCAGACCTGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72235	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				GAGATTAATGTGATGCGGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101312214	101316274	98549932	98553992	72236	hg19	N/A	N/A	N/A	Enhatls178274	enhancer	E_894				TCTTTAGTCAGAGAGAGCTT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72237	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				GGGGACTCAACTTGGGGAGT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72238	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				TCATTGGTTTGTTGTGTGGA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72239	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				AGGCTCAGGGAGGCAGCACA	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72240	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				ACCAGTCACTTAGATTCTCT	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72241	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				CTCATGCCCTCAGGGTGCCC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72242	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				TGGGTGGATGCAACAGGAAG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72243	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				ACTGGGCGTGCAAAAGCGGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72244	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				CCTGGGGCTTCCTTGACCCG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72245	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				CTTGCAGCCACGAGGGGTGG	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72246	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				GGGTGAAGAGAGTGAGTGAC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-166562	chr9	101337415	101338583	98575133	98576301	72247	hg19	N/A	enh85477	N/A	Enhatls178274	enhancer	E_895				AGAAAACAGGGAAATGGGGC	"The knockout of enhancer leads to the downregulation of their respective target gene, resulting in disrupted gene expression, leading to impaired tumor-suppressive functions and enhanced melanoma cell proliferation."	Skin	"A375(other cell line SK-MEL-28, SK-MEL-2, 293T)"	ANP32B	direct	Highly Significant	NA					GABBR2	chr9	98288108	98708935	0				CRISPR-Cas9	Landscape of enhancer disruption and functional screen in melanoma cells	https://doi.org/10.1186/s13059-023-03087-5	37904237	3829
enhrx-lit852	chr1	895889	895910	960509	960530	72248	hg19					enhancer	enh				GAGGCTTCGGGGACTAGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.750007052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit853	chr1	895922	895943	960542	960563	72249	hg19					enhancer	enh				GCGGGCGGCGCCGAGAAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.034621479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit854	chr1	895928	895949	960548	960569	72250	hg19					enhancer	enh				GGCGCCGAGAAACAGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				0.157041245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit855	chr1	895929	895949	960549	960569	72251	hg19					enhancer	enh				GCGCCGAGAAACAGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.507881548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit856	chr1	895934	895954	960554	960574	72252	hg19					enhancer	enh				GAGAAACAGCGGCTGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.39518244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit857	chr1	895961	895982	960581	960602	72253	hg19					enhancer	enh				GCGGGAGTGAGCGACACAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.218082274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit858	chr1	895988	896008	960608	960628	72254	hg19					enhancer	enh				GCCACCGCCGAGCAGCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.541017811									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit859	chr1	895995	896016	960615	960636	72255	hg19					enhancer	enh				GACTGCCGGAGGGCTGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-1.295412752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit860	chr1	896010	896032	960630	960652	72256	hg19					enhancer	enh				GCTTAACGGACGCGGAGACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.415739583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit861	chr1	896013	896035	960633	960655	72257	hg19					enhancer	enh				GTCTCCGCGTCCGTTAAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.390006279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit862	chr1	896020	896042	960640	960662	72258	hg19					enhancer	enh				GGACCCGCGGGCTTAACGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.011511347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit863	chr1	896020	896041	960640	960661	72259	hg19					enhancer	enh				GACCCGCGGGCTTAACGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.374064955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit864	chr1	896030	896051	960650	960671	72260	hg19					enhancer	enh				GCCCGCGGGTCCTCCGCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.189256844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit865	chr1	896034	896054	960654	960674	72261	hg19					enhancer	enh				GCGGGTCCTCCGCGAATCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				0.075393429									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit866	chr1	896037	896057	960657	960677	72262	hg19					enhancer	enh				GGTCCTCCGCGAATCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.369109059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit867	chr1	896043	896064	960663	960684	72263	hg19					enhancer	enh				GGACCCACCGCCGATTCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	indirect	Non Significant	NA				-0.002783034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit868	chr1	896043	896063	960663	960683	72264	hg19					enhancer	enh				GACCCACCGCCGATTCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.21335007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit869	chr1	896065	896085	960685	960705	72265	hg19					enhancer	enh				GCGGGGCTGCATTCGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLHL17	direct	Highly Significant	NA				0.753655966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-243	chr1	1293828	1293848	1358448	1358468	72266	hg19	N/A	enh11412	N/A	Enhatls255	enhancer	enh				GTGCTTCTGCAGAGTGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.106626909	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293828	1293848	1358448	1358468	72267	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTGCTTCTGCAGAGTGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.106626909	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293841	1293861	1358461	1358481	72268	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GAAGCACAAGTTTCCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.109483301	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293850	1293872	1358470	1358492	72269	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTTTCCAAAGCAGGATTCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.032199293	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293862	1293883	1358482	1358503	72270	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GGATTCGGGATGGCAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.267594488	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293863	1293883	1358483	1358503	72271	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GATTCGGGATGGCAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.288004353	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293895	1293915	1358515	1358535	72272	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTGGGACAAAGCCTGGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.93922997	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293896	1293916	1358516	1358536	72273	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GCCCCAGGCTTTGTCCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.328050408	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293900	1293920	1358520	1358540	72274	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GCCGAGTGGGACAAAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.069953862	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293901	1293922	1358521	1358542	72275	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GAGCCGAGTGGGACAAAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.173532346	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293913	1293935	1358533	1358555	72276	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GGAGAGAGACTTAGAGCCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.618298192	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293913	1293934	1358533	1358554	72277	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GAGAGAGACTTAGAGCCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.341344485	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293960	1293981	1358580	1358601	72278	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTCACCGCGGGTGCTAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.547836889	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293961	1293981	1358581	1358601	72279	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTCACCGCGGGTGCTAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.444145097	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293965	1293986	1358585	1358606	72280	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GTGATGTCACCGCGGGTGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.754518398	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293973	1293993	1358593	1358613	72281	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GGCCTCCGTGATGTCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.271737095	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1293990	1294010	1358610	1358630	72282	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GCCTGGGCCTGTCTACGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				-0.190225612	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1294000	1294020	1358620	1358640	72283	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GCGGTCCCCAGACCGTAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	direct	Highly Significant	NA				0.398404096	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-243	chr1	1294097	1294117	1358717	1358737	72284	hg19	N/A	enh11412	N/A	N/A	enhancer	enh				GGCCCAGCCCCTCACCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MXRA8	indirect	Non Significant	NA				0.097117672	MXRA8	chr1	1352688	1361777	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	242
enhrx-lit870	chr1	1334588	1334608	1399208	1399228	72285	hg19					enhancer	enh				GGCGCACCCTCAGGGTCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.288367368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit871	chr1	1334609	1334629	1399229	1399249	72286	hg19					enhancer	enh				GCCGGCGCCCCGGGATCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.988453684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit872	chr1	1334631	1334652	1399251	1399272	72287	hg19					enhancer	enh				GGTCGGCAGCTCCCGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.465312683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit873	chr1	1334631	1334651	1399251	1399271	72288	hg19					enhancer	enh				GTCGGCAGCTCCCGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.357377755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit874	chr1	1334637	1334659	1399257	1399279	72289	hg19					enhancer	enh				GCTGCAGGGTCGGCAGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				0.086308746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit875	chr1	1334676	1334697	1399296	1399317	72290	hg19					enhancer	enh				GGCGGCACAAAATGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.732663167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit876	chr1	1334676	1334696	1399296	1399316	72291	hg19					enhancer	enh				GCGGCACAAAATGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	direct	Highly Significant	NA				0.282224248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit877	chr1	1334682	1334702	1399302	1399322	72292	hg19					enhancer	enh				GAGTCGGCGGCACAAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.973238639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit878	chr1	1334685	1334705	1399305	1399325	72293	hg19					enhancer	enh				GGGGAGTCGGCGGCACAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-1.030153138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit879	chr1	1334704	1334726	1399324	1399346	72294	hg19					enhancer	enh				GCCCTGAGGGAAGAAGCCGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.755745059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit880	chr1	1334705	1334726	1399325	1399346	72295	hg19					enhancer	enh				GCCCTGAGGGAAGAAGCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.441431562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit881	chr1	1334719	1334741	1399339	1399361	72296	hg19					enhancer	enh				GCTTCGCGAGGAGCCGCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-1.194840571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit882	chr1	1334724	1334745	1399344	1399365	72297	hg19					enhancer	enh				GCGGCTCCTCGCGAAGCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNL2	indirect	Non Significant	NA				-0.588856744									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit883	chr1	1370871	1370892	1435491	1435512	72298	hg19					enhancer	enh				GTGCCTCGGTCGTATCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				0.072763548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit884	chr1	1370877	1370898	1435497	1435518	72299	hg19					enhancer	enh				GCACCAGCCGAGATACGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				0.072383069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit885	chr1	1370909	1370931	1435529	1435551	72300	hg19					enhancer	enh				GCACGAGCGGACCCCGACACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	direct	Highly Significant	NA				0.500946791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit886	chr1	1370933	1370955	1435553	1435575	72301	hg19					enhancer	enh				GCCTCTCCGGGGTCTGTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.169090141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit887	chr1	1370952	1370972	1435572	1435592	72302	hg19					enhancer	enh				GCGTGGCCCTCCGCTCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				0.131151982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit888	chr1	1370965	1370986	1435585	1435606	72303	hg19					enhancer	enh				GCCCACGCCCTCCGGCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.157687926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit889	chr1	1370993	1371013	1435613	1435633	72304	hg19					enhancer	enh				GAGCGGCCACACCCACGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.429499454									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit890	chr1	1371045	1371065	1435665	1435685	72305	hg19					enhancer	enh				GGCGCGTCACCGCGCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.118450658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit891	chr1	1371045	1371066	1435665	1435686	72306	hg19					enhancer	enh				GGGCGCGTCACCGCGCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				0.114277493									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit892	chr1	1371051	1371072	1435671	1435692	72307	hg19					enhancer	enh				GCTGCAGGGCGCGTCACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	direct	Highly Significant	NA				0.275090219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit893	chr1	1371051	1371073	1435671	1435693	72308	hg19					enhancer	enh				GGCTGCAGGGCGCGTCACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.296660193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit894	chr1	1371113	1371134	1435733	1435754	72309	hg19					enhancer	enh				GAGCATCGCGCGCGAGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.268795698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit895	chr1	1371114	1371135	1435734	1435755	72310	hg19					enhancer	enh				GGAGCATCGCGCGCGAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	direct	Highly Significant	NA				0.635388219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit896	chr1	1371114	1371134	1435734	1435754	72311	hg19					enhancer	enh				GAGCATCGCGCGCGAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.361633558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit897	chr1	1371120	1371142	1435740	1435762	72312	hg19					enhancer	enh				GTCCAGGGGAGCATCGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	direct	Highly Significant	NA				0.361225893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit898	chr1	1371127	1371148	1435747	1435768	72313	hg19					enhancer	enh				GATGCTCCCCTGGACGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.317704478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit899	chr1	1371137	1371158	1435757	1435778	72314	hg19					enhancer	enh				GGCCAGGCCGAGCGCCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.366650566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit900	chr1	1371137	1371157	1435757	1435777	72315	hg19					enhancer	enh				GCCAGGCCGAGCGCCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.954189698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit901	chr1	1371150	1371171	1435770	1435791	72316	hg19					enhancer	enh				GCCTGGCCCTGAGCTTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				-0.092309336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit902	chr1	1371159	1371181	1435779	1435801	72317	hg19					enhancer	enh				GCCAGCGCCAGCCGCAAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VWA1	indirect	Non Significant	NA				0.151652378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-275	chr1	1395239	1395261	1459859	1459881	72318	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GCCCCAGTCACGTGTCACATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.572998882	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395245	1395267	1459865	1459887	72319	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GATCCTCCATGTGACACGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.212364019	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395316	1395338	1459936	1459958	72320	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GTCTACCGGCAGCAGCTGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.253073207	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395322	1395344	1459942	1459964	72321	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GCTGCTGCCGGTAGACGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				0.196062901	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395332	1395352	1459952	1459972	72322	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GGGCTCCAGGGAGCGTCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.024856826	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395417	1395438	1460037	1460058	72323	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GAGCCAGGAGCAGGACCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.126671254	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395419	1395441	1460039	1460061	72324	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GAGGTCCTGCTCCTGGCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				-0.654096212	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-275	chr1	1395421	1395441	1460041	1460061	72325	hg19	N/A	N/A	N/A	Enhatls285	enhancer	enh				GGTCCTGCTCCTGGCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATAD3C	indirect	Non Significant	NA				0.158374629	ATAD3C	chr1	1449688	1470163	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	274
enhrx-lit903	chr1	1534845	1534865	1599465	1599485	72326	hg19					enhancer	enh				GGCCGGCATGCAGGACATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	direct	Highly Significant	NA				0.469437923									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit904	chr1	1534862	1534882	1599482	1599502	72327	hg19					enhancer	enh				GAGTTCACCGCCGAGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.073323708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit905	chr1	1534866	1534887	1599486	1599507	72328	hg19					enhancer	enh				GCGTGGAGTTCACCGCCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.395307804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit906	chr1	1534874	1534894	1599494	1599514	72329	hg19					enhancer	enh				GTGAACTCCACGCACTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.126843426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit907	chr1	1534904	1534924	1599524	1599544	72330	hg19					enhancer	enh				GTCTCTGGCGCGGCGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				0.167202151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit908	chr1	1534924	1534945	1599544	1599565	72331	hg19					enhancer	enh				GGGCCCAGCGCGCAGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.197290599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit909	chr1	1534925	1534945	1599545	1599565	72332	hg19					enhancer	enh				GGCCCAGCGCGCAGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-1.059140093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit910	chr1	1534930	1534952	1599550	1599572	72333	hg19					enhancer	enh				GCAGCCGCTGCCGCTGCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.21003383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit911	chr1	1534931	1534952	1599551	1599572	72334	hg19					enhancer	enh				GCAGCCGCTGCCGCTGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.075764154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit912	chr1	1534946	1534967	1599566	1599587	72335	hg19					enhancer	enh				GGCTGCAGGCACAGGCGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.590851387									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit913	chr1	1534947	1534967	1599567	1599587	72336	hg19					enhancer	enh				GCTGCAGGCACAGGCGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.248857379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit914	chr1	1534966	1534987	1599586	1599607	72337	hg19					enhancer	enh				GAGGACGCTGTCGTGCACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	direct	Highly Significant	NA				0.580661636									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit915	chr1	1534966	1534986	1599586	1599606	72338	hg19					enhancer	enh				GAGGACGCTGTCGTGCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				0.091067624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit916	chr1	1534972	1534994	1599592	1599614	72339	hg19					enhancer	enh				GCTGTCGTGCACGTCGGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.132919478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit917	chr1	1534987	1535007	1599607	1599627	72340	hg19					enhancer	enh				GGGCAGCAGGTAGTCGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				-0.237338325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit918	chr1	1535016	1535036	1599636	1599656	72341	hg19					enhancer	enh				GTGCGAGCGCGTGCTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	indirect	Non Significant	NA				0.08230198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit919	chr1	1535057	1535077	1599677	1599697	72342	hg19					enhancer	enh				GCGCTCAACTGCTCGTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf233	direct	Highly Significant	NA				0.219321732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-458	chr1	2126040	2126061	2194601	2194622	72343	hg19	N/A	enh11422	N/A	Enhatls476	enhancer	enh				GAATAGAGCGGGAGGCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				-1.738210787	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126074	2126094	2194635	2194655	72344	hg19	N/A	enh11422	N/A	Enhatls476	enhancer	enh				GCACGTGGGAGCGGGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.23797784	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126112	2126134	2194673	2194695	72345	hg19	N/A	enh11422	N/A	Enhatls476	enhancer	enh				GCTCCCGGCCTCACCCGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.295120628	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126112	2126134	2194673	2194695	72346	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GCTCCCGGCCTCACCCGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.295120628	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126180	2126201	2194741	2194762	72347	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GCCTCCATCCAAGCCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				0.130210307	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126180	2126200	2194741	2194761	72348	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GCCTCCATCCAAGCCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				0.015361966	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126196	2126217	2194757	2194778	72349	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GCGCTCACTTCCGCCCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				-0.217971725	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126197	2126217	2194758	2194778	72350	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GCGCTCACTTCCGCCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.353082854	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126202	2126222	2194763	2194783	72351	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GGCTTGCGCTCACTTCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				0.074074295	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126202	2126223	2194763	2194784	72352	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GGGCTTGCGCTCACTTCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				-0.074779369	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126202	2126224	2194763	2194785	72353	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GGGGCTTGCGCTCACTTCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.42121257	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126293	2126313	2194854	2194874	72354	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GGGTTCCGACTGTCTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	indirect	Non Significant	NA				-0.494345271	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-458	chr1	2126354	2126376	2194915	2194937	72355	hg19	N/A	enh11422	N/A	N/A	enhancer	enh				GTTCCTTCGTCCTGCACCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf86	direct	Highly Significant	NA				0.216622472	FAAP20	chr1	2184460	2194775	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	457
enhrx-661	chr1	3689177	3689198	3772613	3772634	72356	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAAGGTCTGGGGCCAGTAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.163955599	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689177	3689198	3772613	3772634	72357	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAAGGTCTGGGGCCAGTAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.163955599	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689319	3689340	3772755	3772776	72358	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GTCTCTGGGCTCCGCAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.322115967	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689319	3689340	3772755	3772776	72359	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GTCTCTGGGCTCCGCAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.322115967	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689319	3689341	3772755	3772777	72360	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCCCCTGCGGAGCCCAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-1.096118287	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689319	3689341	3772755	3772777	72361	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCCCCTGCGGAGCCCAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-1.096118287	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689328	3689350	3772764	3772786	72362	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAGCCCAGAGACGCGGGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.301933756	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689328	3689350	3772764	3772786	72363	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAGCCCAGAGACGCGGGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.301933756	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689330	3689350	3772766	3772786	72364	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCCCAGAGACGCGGGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				0.057890715	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689330	3689350	3772766	3772786	72365	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCCCAGAGACGCGGGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				0.057890715	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689335	3689355	3772771	3772791	72366	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAGACGCGGGGACACAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.217058825	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689335	3689355	3772771	3772791	72367	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GAGACGCGGGGACACAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.217058825	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689344	3689364	3772780	3772800	72368	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GGACACAGGTGAGGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.189441063	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689344	3689364	3772780	3772800	72369	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GGACACAGGTGAGGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.189441063	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689377	3689399	3772813	3772835	72370	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GGCTTCCCGGTGCGGCCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.050754138	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689377	3689399	3772813	3772835	72371	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GGCTTCCCGGTGCGGCCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	indirect	Non Significant	NA				-0.050754138	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689378	3689399	3772814	3772835	72372	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCTTCCCGGTGCGGCCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.207046011	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689378	3689399	3772814	3772835	72373	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCTTCCCGGTGCGGCCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.207046011	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689407	3689427	3772843	3772863	72374	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCGACTGTGCGCGGCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.430503837	CCDC27	chr1	3752449	3771645	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689407	3689427	3772843	3772863	72375	hg19	N/A	enh98421	N/A	N/A	enhancer	enh				GCGACTGTGCGCGGCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.430503837	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-661	chr1	3689407	3689427	3772843	3772863	72376	hg19	N/A	enh98421	N/A	Enhatls696	enhancer	enh				GCGACTGTGCGCGGCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMIM1	direct	Highly Significant	NA				0.430503837	SMIM1	chr1	3772748	3775982	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	660
enhrx-lit920	chr1	3773968	3773988	3857404	3857424	72377	hg19					enhancer	enh				GCCTGCGCACAAGACCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.138539555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit921	chr1	3773985	3774005	3857421	3857441	72378	hg19					enhancer	enh				GGGAAAAGTGAGGCCCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.478091701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit922	chr1	3774014	3774035	3857450	3857471	72379	hg19					enhancer	enh				GGGTAATGTAGTTTCCGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	direct	Highly Significant	NA				0.305632436									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit923	chr1	3774015	3774035	3857451	3857471	72380	hg19					enhancer	enh				GGTAATGTAGTTTCCGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.413153151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit924	chr1	3774021	3774042	3857457	3857478	72381	hg19					enhancer	enh				GTAGTTTCCGGGATCGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	direct	Highly Significant	NA				0.285016652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit925	chr1	3774031	3774053	3857467	3857489	72382	hg19					enhancer	enh				GGCACAGGCCGGGTGCCGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.15651558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit926	chr1	3774031	3774052	3857467	3857488	72383	hg19					enhancer	enh				GCACAGGCCGGGTGCCGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.324200488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit927	chr1	3774043	3774065	3857479	3857501	72384	hg19					enhancer	enh				GCTCTGCAAGCTGGCACAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.340331952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit928	chr1	3774044	3774065	3857480	3857501	72385	hg19					enhancer	enh				GCTCTGCAAGCTGGCACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	direct	Highly Significant	NA				0.604176471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit929	chr1	3774048	3774069	3857484	3857505	72386	hg19					enhancer	enh				GTGAGCTCTGCAAGCTGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.068422428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit930	chr1	3774050	3774070	3857486	3857506	72387	hg19					enhancer	enh				GCCAGCTTGCAGAGCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	direct	Highly Significant	NA				0.501601604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit931	chr1	3774054	3774076	3857490	3857512	72388	hg19					enhancer	enh				GCACCTGGTGAGCTCTGCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.147220961									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit932	chr1	3774063	3774085	3857499	3857521	72389	hg19					enhancer	enh				GCTCACCAGGTGCAGACCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.116997591									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit933	chr1	3774071	3774091	3857507	3857527	72390	hg19					enhancer	enh				GGTGCAGACCCCTGCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.077363415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit934	chr1	3774074	3774096	3857510	3857532	72391	hg19					enhancer	enh				GCAGACCCCTGCGGCCAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.977245102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit935	chr1	3774084	3774106	3857520	3857542	72392	hg19					enhancer	enh				GATCCGTCCTCGCCCTGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				-0.113651407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit936	chr1	3774091	3774111	3857527	3857547	72393	hg19					enhancer	enh				GCTCAGATCCGTCCTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	direct	Highly Significant	NA				0.413609774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit937	chr1	3774093	3774114	3857529	3857550	72394	hg19					enhancer	enh				GCGAGGACGGATCTGAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.16316178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit938	chr1	3774102	3774122	3857538	3857558	72395	hg19					enhancer	enh				GATCTGAGCAGCTGGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.018253818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit939	chr1	3774117	3774137	3857553	3857573	72396	hg19					enhancer	enh				GCAGCAGGTGCCACCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DFFB	indirect	Non Significant	NA				0.066746075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit940	chr1	6484792	6484812	6424732	6424752	72397	hg19					enhancer	enh				GGCGGGCCCGAGTCTTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	direct	Highly Significant	NA				0.292151113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit941	chr1	6484801	6484822	6424741	6424762	72398	hg19					enhancer	enh				GAGTCTTAAGCCGGCGTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.06448499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit942	chr1	6484801	6484821	6424741	6424761	72399	hg19					enhancer	enh				GAGTCTTAAGCCGGCGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				0.121295729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit943	chr1	6484823	6484844	6424763	6424784	72400	hg19					enhancer	enh				GGCTCCGGCCCCAGAGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-1.320026252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit944	chr1	6484824	6484844	6424764	6424784	72401	hg19					enhancer	enh				GCTCCGGCCCCAGAGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				0.080709268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit945	chr1	6484829	6484849	6424769	6424789	72402	hg19					enhancer	enh				GGCCCCAGAGCGCGGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.798459425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit946	chr1	6484830	6484850	6424770	6424790	72403	hg19					enhancer	enh				GCTCCGCCGCGCTCTGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	direct	Highly Significant	NA				0.442512522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit947	chr1	6484836	6484857	6424776	6424797	72404	hg19					enhancer	enh				GCGCTCCGCTCCGCCGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.204442403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit948	chr1	6484846	6484866	6424786	6424806	72405	hg19					enhancer	enh				GAGCGGAGCGCCAGGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	direct	Highly Significant	NA				0.381797311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit949	chr1	6484851	6484871	6424791	6424811	72406	hg19					enhancer	enh				GAGCGCCAGGCAGCGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.671312296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit950	chr1	6484859	6484879	6424799	6424819	72407	hg19					enhancer	enh				GGCCTCCGCTCCGCGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.57421285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit951	chr1	6484903	6484924	6424843	6424864	72408	hg19					enhancer	enh				GCCGTCGGGGATCTGCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	direct	Highly Significant	NA				0.373880622									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit952	chr1	6484918	6484938	6424858	6424878	72409	hg19					enhancer	enh				GAGCCCGCGGTGCGGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ESPN	indirect	Non Significant	NA				-0.175754702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit953	chr1	6614465	6614485	6554405	6554425	72410	hg19					enhancer	enh				GCCGGCGGCTGAGGATGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.007692042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit954	chr1	6614494	6614516	6554434	6554456	72411	hg19					enhancer	enh				GCCTTGCGGACCCGCAGCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-1.820371208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit955	chr1	6614499	6614521	6554439	6554461	72412	hg19					enhancer	enh				GCGGACCCGCAGCCAAGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-2.087738643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit956	chr1	6614501	6614521	6554441	6554461	72413	hg19					enhancer	enh				GGACCCGCAGCCAAGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-2.102177301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit957	chr1	6614514	6614534	6554454	6554474	72414	hg19					enhancer	enh				GGGGTTCCTGCCGTTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-2.119759458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit958	chr1	6614514	6614536	6554454	6554476	72415	hg19					enhancer	enh				GCGGGGTTCCTGCCGTTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-1.190231479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit959	chr1	6614534	6614556	6554474	6554496	72416	hg19					enhancer	enh				GACTCGGGACTGCTGCTAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.132896928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit960	chr1	6614535	6614556	6554475	6554496	72417	hg19					enhancer	enh				GACTCGGGACTGCTGCTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-1.466550583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit961	chr1	6614543	6614564	6554483	6554504	72418	hg19					enhancer	enh				GCAGTCCCGAGTCCGCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.4939646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit962	chr1	6614551	6614571	6554491	6554511	72419	hg19					enhancer	enh				GGACCCAGCATGGCGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				0.042815817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit963	chr1	6614552	6614573	6554492	6554513	72420	hg19					enhancer	enh				GAGGACCCAGCATGGCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	direct	Highly Significant	NA				0.4283509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit964	chr1	6614558	6614578	6554498	6554518	72421	hg19					enhancer	enh				GCCCTGAGGACCCAGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.87510265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit965	chr1	6614561	6614582	6554501	6554522	72422	hg19					enhancer	enh				GTAGGCCCTGAGGACCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-1.232198926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit966	chr1	6614572	6614594	6554512	6554534	72423	hg19					enhancer	enh				GATTCTCGCGCGGTAGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.31162934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit967	chr1	6614584	6614605	6554524	6554545	72424	hg19					enhancer	enh				GGATCTCGCGAGATTCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				0.057936459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit968	chr1	6614584	6614604	6554524	6554544	72425	hg19					enhancer	enh				GATCTCGCGAGATTCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				0.038438529									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit969	chr1	6614587	6614608	6554527	6554548	72426	hg19					enhancer	enh				GAGAATCTCGCGAGATCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				-0.977384816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit970	chr1	6614700	6614720	6554640	6554660	72427	hg19					enhancer	enh				GTTCCAGCCGATCTGGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				0.012653553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit971	chr1	6614741	6614761	6554681	6554701	72428	hg19					enhancer	enh				GGGAATTTGCGTAACGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOL9	indirect	Non Significant	NA				0.13303021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit972	chr1	6845329	6845349	6785269	6785289	72429	hg19					enhancer	enh				GACCAATCCTTTCAGTCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.410888334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit973	chr1	6845366	6845386	6785306	6785326	72430	hg19					enhancer	enh				GTCCTATCCATCCGGCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.16639553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit974	chr1	6845374	6845394	6785314	6785334	72431	hg19					enhancer	enh				GGAGGAGCGTCCTATCCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.299379925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit975	chr1	6845412	6845434	6785352	6785374	72432	hg19					enhancer	enh				GCCGCCAATCGCCCCGCACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.269963416									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit976	chr1	6845459	6845479	6785399	6785419	72433	hg19					enhancer	enh				GCCCAACGGGAGCTGTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	direct	Highly Significant	NA				0.431219503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit977	chr1	6845543	6845564	6785483	6785504	72434	hg19					enhancer	enh				GCGGTACGAGGCGCGCGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.146213502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit978	chr1	6845543	6845563	6785483	6785503	72435	hg19					enhancer	enh				GCGGTACGAGGCGCGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.299084678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit979	chr1	6845550	6845570	6785490	6785510	72436	hg19					enhancer	enh				GAGGCGCGCGCTCGGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.01759889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit980	chr1	6845557	6845578	6785497	6785518	72437	hg19					enhancer	enh				GCGCTCGGGGTCCCGGTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				-0.137619425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit981	chr1	6845607	6845629	6785547	6785569	72438	hg19					enhancer	enh				GAAATGGCTGCCGAAAACAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.136151492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit982	chr1	6845612	6845633	6785552	6785573	72439	hg19					enhancer	enh				GGCTGCCGAAAACAAGCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.03153888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit983	chr1	6845613	6845633	6785553	6785573	72440	hg19					enhancer	enh				GCTGCCGAAAACAAGCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.053284302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-891	chr1	6845693	6845713	6785633	6785653	72441	hg19	N/A	N/A	N/A	Enhatls945	enhancer	enh				GATGCCCGGGATGTCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMTA1	indirect	Non Significant	NA				0.047726254	CAMTA1	chr1	6785453	7769706	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	890
enhrx-1074	chr1	9970146	9970167	9910088	9910109	72442	hg19	N/A	N/A	N/A	Enhatls1171	enhancer	enh				GCTTACCTGGGCCGCCCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-0.139638789	CTNNBIP1	chr1	9848275	9910336	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1073
enhrx-lit984	chr1	9970203	9970223	9910145	9910165	72443	hg19					enhancer	enh				GCGCGCGGCGGCCTGTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	direct	Highly Significant	NA				0.205340206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit985	chr1	9970217	9970237	9910159	9910179	72444	hg19					enhancer	enh				GGCTGAGCACGCCCCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				0.055018283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit986	chr1	9970217	9970238	9910159	9910180	72445	hg19					enhancer	enh				GGGCTGAGCACGCCCCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-0.517936717									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit987	chr1	9970223	9970245	9910165	9910187	72446	hg19					enhancer	enh				GCTGCTCGGGCTGAGCACGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-0.107579318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit988	chr1	9970229	9970250	9910171	9910192	72447	hg19					enhancer	enh				GCTCAGCCCGAGCAGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-0.346795018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit989	chr1	9970247	9970269	9910189	9910211	72448	hg19					enhancer	enh				GCTGCTACTGCCGCCGCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				0.031672181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit990	chr1	9970295	9970315	9910237	9910257	72449	hg19					enhancer	enh				GTGACTCTCGGAGCGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-2.343024232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit991	chr1	9970301	9970322	9910243	9910264	72450	hg19					enhancer	enh				GCTCCGAGAGTCACCGCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-0.101876218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit992	chr1	9970301	9970321	9910243	9910263	72451	hg19					enhancer	enh				GCTCCGAGAGTCACCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	direct	Highly Significant	NA				0.914463407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit993	chr1	9970306	9970326	9910248	9910268	72452	hg19					enhancer	enh				GAGAGTCACCGCGGTGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	indirect	Non Significant	NA				-1.100377177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit994	chr1	9970328	9970348	9910270	9910290	72453	hg19					enhancer	enh				GAGGGAGGCGCCAGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	direct	Highly Significant	NA				0.667322725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit995	chr1	9970482	9970502	9910424	9910444	72454	hg19					enhancer	enh				GTTAACCAATTCGCGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CTNNBIP1	direct	Highly Significant	NA				0.453310164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-1256	chr1	11159719	11159739	11099662	11099682	72455	hg19	N/A	N/A	N/A	Enhatls1360	enhancer	enh				GCGGCCGCCGGAAGCCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	direct	Highly Significant	NA				0.349124333	EXOSC10	chr1	11066617	11099869	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1255
enhrx-1256	chr1	11159738	11159758	11099681	11099701	72456	hg19	N/A	N/A	N/A	Enhatls1360	enhancer	enh				GGGGTACCAGGAGTCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.097422162	EXOSC10	chr1	11066617	11099869	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1255
enhrx-1256	chr1	11159766	11159788	11099709	11099731	72457	hg19	N/A	N/A	N/A	Enhatls1360	enhancer	enh				GCTTTGTGAAGGTGAGTTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.374445918	EXOSC10	chr1	11066617	11099869	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1255
enhrx-lit996	chr1	11159808	11159828	11099751	11099771	72458	hg19					enhancer	enh				GACGGAGAGATGGTGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.151445422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit997	chr1	11159818	11159840	11099761	11099783	72459	hg19					enhancer	enh				GCAACCAAATCCGACGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				0.127889061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit998	chr1	11159826	11159847	11099769	11099790	72460	hg19					enhancer	enh				GACCAGCGCAACCAAATCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.919031258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit999	chr1	11159840	11159860	11099783	11099803	72461	hg19					enhancer	enh				GCTGGTCGCCGACAGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-1.566978118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1000	chr1	11159840	11159861	11099783	11099804	72462	hg19					enhancer	enh				GCTGGTCGCCGACAGGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-1.891028192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1001	chr1	11159847	11159869	11099790	11099812	72463	hg19					enhancer	enh				GCCGACAGGACCCTGGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-6.078000499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1002	chr1	11159847	11159868	11099790	11099811	72464	hg19					enhancer	enh				GCCGACAGGACCCTGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-1.131770677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1003	chr1	11159854	11159875	11099797	11099818	72465	hg19					enhancer	enh				GGACCCTGGGCTCCCGGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.246636414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1004	chr1	11159855	11159875	11099798	11099818	72466	hg19					enhancer	enh				GACCCTGGGCTCCCGGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-1.963312774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1005	chr1	11159861	11159883	11099804	11099826	72467	hg19					enhancer	enh				GCCACCCAGTACCCGGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				0.017145745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1006	chr1	11159899	11159921	11099842	11099864	72468	hg19					enhancer	enh				GCTCTCGCGAGACGAGCCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.361930621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1007	chr1	11159917	11159938	11099860	11099881	72469	hg19					enhancer	enh				GAGCTTGTCGGCCGAGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.088791494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1008	chr1	11159917	11159937	11099860	11099880	72470	hg19					enhancer	enh				GAGCTTGTCGGCCGAGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.566079755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1009	chr1	11159945	11159965	11099888	11099908	72471	hg19					enhancer	enh				GTGCGCACCACGCATGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	direct	Highly Significant	NA				0.553709552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1010	chr1	11159955	11159975	11099898	11099918	72472	hg19					enhancer	enh				GCTTCGACCTGGCGCATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				-0.115205589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1011	chr1	11159980	11160001	11099923	11099944	72473	hg19					enhancer	enh				GCGGGGCGTCTGATTATAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	indirect	Non Significant	NA				0.032350039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1012	chr1	11160051	11160073	11099994	11100016	72474	hg19					enhancer	enh				GCAGGTGCCCCACCCTAAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXOSC10	direct	Highly Significant	NA				0.391292532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-1393	chr1	11907004	11907024	11846947	11846967	72475	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GACTAGCTAAGGACAATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.510479887	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907076	11907096	11847019	11847039	72476	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GAGGGAATGAGCTTCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.828272751	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907092	11907114	11847035	11847057	72477	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GCATTGGTCCCTTTCCTGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	direct	Highly Significant	NA				0.213658759	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907104	11907124	11847047	11847067	72478	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GGAGACACCTTCAGCAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.010418157	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907140	11907162	11847083	11847105	72479	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GAACTGGGGATGGAAATGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.356548195	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907140	11907162	11847083	11847105	72480	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GAACTGGGGATGGAAATGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.356548195	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907145	11907165	11847088	11847108	72481	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GAGGAACTGGGGATGGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.472511958	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907145	11907165	11847088	11847108	72482	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GAGGAACTGGGGATGGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.472511958	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907156	11907177	11847099	11847120	72483	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GCTTCCGGGTAAGAGGAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.111757051	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907156	11907177	11847099	11847120	72484	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GCTTCCGGGTAAGAGGAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.111757051	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907157	11907177	11847100	11847120	72485	hg19	hs2123	N/A	N/A	Enhatls1500	enhancer	enh				GCTTCCGGGTAAGAGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.032867656	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907157	11907177	11847100	11847120	72486	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GCTTCCGGGTAAGAGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.032867656	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907164	11907186	11847107	11847129	72487	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GCTGTAACAGCTTCCGGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.360460723	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907175	11907197	11847118	11847140	72488	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GCTGTTACAGCCCAGTCCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.232404807	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907188	11907210	11847131	11847153	72489	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GGATTGGAGCCCAGAGCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	direct	Highly Significant	NA				0.360655683	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907188	11907209	11847131	11847152	72490	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GATTGGAGCCCAGAGCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	direct	Highly Significant	NA				0.311338423	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907189	11907209	11847132	11847152	72491	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GATTGGAGCCCAGAGCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				0.153419732	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907194	11907215	11847137	11847158	72492	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GGACAGGATTGGAGCCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				0.127160492	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907194	11907214	11847137	11847157	72493	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GACAGGATTGGAGCCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				0.165461145	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907232	11907254	11847175	11847197	72494	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GCTGGATCTCCGCAGGCTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				-0.396280809	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907323	11907343	11847266	11847286	72495	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GATGGAGGTGCCCTCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	indirect	Non Significant	NA				0.014633236	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-1393	chr1	11907353	11907373	11847296	11847316	72496	hg19	hs2123	N/A	N/A	N/A	enhancer	enh				GGGCTGACTTCCCCGGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPPA	direct	Highly Significant	NA				0.446491065	NPPA	chr1	11845708	11848345	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1392
enhrx-lit1013	chr1	15943912	15943933	15617417	15617438	72497	hg19					enhancer	enh				GGCGCGCTTGGCGGCAGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				0.023503324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1014	chr1	15943913	15943933	15617418	15617438	72498	hg19					enhancer	enh				GCGCGCTTGGCGGCAGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.406364014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1015	chr1	15943942	15943964	15617447	15617469	72499	hg19					enhancer	enh				GCCGGCAGGCAGACGGACTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.344619755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1016	chr1	15943949	15943971	15617454	15617476	72500	hg19					enhancer	enh				GGCAGACGGACTCGCAGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.007492556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1017	chr1	15943950	15943971	15617455	15617476	72501	hg19					enhancer	enh				GCAGACGGACTCGCAGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.565638904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1018	chr1	15943953	15943974	15617458	15617479	72502	hg19					enhancer	enh				GACGGACTCGCAGGCGTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.241825795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1019	chr1	15943957	15943977	15617462	15617482	72503	hg19					enhancer	enh				GACTCGCAGGCGTGTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.381908521									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1020	chr1	15943973	15943995	15617478	15617500	72504	hg19					enhancer	enh				GCGGCGGCCGTGCTTGCTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.331315826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1021	chr1	15943975	15943995	15617480	15617500	72505	hg19					enhancer	enh				GGCGGCCGTGCTTGCTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.430247554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1022	chr1	15943976	15943996	15617481	15617501	72506	hg19					enhancer	enh				GCGGCCGTGCTTGCTAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.048359993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1023	chr1	15943979	15943999	15617484	15617504	72507	hg19					enhancer	enh				GCCGTGCTTGCTAGTGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.603414067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1024	chr1	15943984	15944004	15617489	15617509	72508	hg19					enhancer	enh				GCTTGCTAGTGAGGGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	indirect	Non Significant	NA				-0.239461007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1025	chr1	15944010	15944030	15617515	15617535	72509	hg19					enhancer	enh				GACTCACTGAGCGTGTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DDI2	direct	Highly Significant	NA				0.86036843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1026	chr1	16067600	16067620	15741105	15741125	72510	hg19					enhancer	enh				GCCTCAGTCCCGGGAACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.073806081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1027	chr1	16067618	16067639	15741123	15741144	72511	hg19					enhancer	enh				GCCCGGGAAAGGGAAGCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.480545253									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1028	chr1	16067661	16067683	15741166	15741188	72512	hg19					enhancer	enh				GCTCAGTCTAGAGAAAGGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.02674101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1029	chr1	16067662	16067683	15741167	15741188	72513	hg19					enhancer	enh				GCTCAGTCTAGAGAAAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.019046496									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1030	chr1	16067668	16067690	15741173	15741195	72514	hg19					enhancer	enh				GAATGGTGCTCAGTCTAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	direct	Highly Significant	NA				0.558619751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1031	chr1	16067675	16067695	15741180	15741200	72515	hg19					enhancer	enh				GACTGAGCACCATTCCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.40444789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1032	chr1	16067687	16067707	15741192	15741212	72516	hg19					enhancer	enh				GAGAGCACACCCACGGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.087408401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1033	chr1	16067692	16067713	15741197	15741218	72517	hg19					enhancer	enh				GGCGCTGAGAGCACACCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.012923022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1034	chr1	16067692	16067712	15741197	15741217	72518	hg19					enhancer	enh				GCGCTGAGAGCACACCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	direct	Highly Significant	NA				0.279377752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1035	chr1	16067723	16067745	15741228	15741250	72519	hg19					enhancer	enh				GGCATCCATCTCTGCAGTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.07873409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1036	chr1	16067723	16067744	15741228	15741249	72520	hg19					enhancer	enh				GCATCCATCTCTGCAGTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	direct	Highly Significant	NA				0.235604343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1037	chr1	16067730	16067752	15741235	15741257	72521	hg19					enhancer	enh				GCAGAGATGGATGCCAACTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.294812199									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1038	chr1	16067735	16067756	15741240	15741261	72522	hg19					enhancer	enh				GATGGATGCCAACTCCCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.11379612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1039	chr1	16067738	16067758	15741243	15741263	72523	hg19					enhancer	enh				GGATGCCAACTCCCTGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.001227351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1040	chr1	16067746	16067767	15741251	15741272	72524	hg19					enhancer	enh				GTCCTGCCCCTGCCAGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-1.363276548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1041	chr1	16067752	16067774	15741257	15741279	72525	hg19					enhancer	enh				GGCAGCAGTCCTGCCCCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				-0.012046088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1042	chr1	16067752	16067773	15741257	15741278	72526	hg19					enhancer	enh				GCAGCAGTCCTGCCCCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.14113665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1043	chr1	16067797	16067817	15741302	15741322	72527	hg19					enhancer	enh				GCCACACCCCAAGTCTGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC25A34	indirect	Non Significant	NA				0.146382046									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1044	chr1	16347695	16347717	16021200	16021222	72528	hg19					enhancer	enh				GCTTCTCAAAGCACACGTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	direct	Highly Significant	NA				0.291680799									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1045	chr1	16347758	16347778	16021263	16021283	72529	hg19					enhancer	enh				GTGAATTGGGGTCAGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				-0.376856422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1046	chr1	16347883	16347905	16021388	16021410	72530	hg19					enhancer	enh				GCTGGGAATCCTGGCTCTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				-0.054664933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1047	chr1	16347911	16347932	16021416	16021437	72531	hg19					enhancer	enh				GCTGCCTGTCTAAGATCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				-0.069607847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1048	chr1	16347911	16347933	16021416	16021438	72532	hg19					enhancer	enh				GGCTGCCTGTCTAAGATCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				0.176031368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1049	chr1	16347934	16347956	16021439	16021461	72533	hg19					enhancer	enh				GAAATGGTGTCTCAGGGAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				-0.992179445									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1050	chr1	16347936	16347956	16021441	16021461	72534	hg19					enhancer	enh				GAAATGGTGTCTCAGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				0.077646113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1051	chr1	16347998	16348018	16021503	16021523	72535	hg19					enhancer	enh				GGCACTCAGGGTAATTAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	indirect	Non Significant	NA				-0.21621669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1052	chr1	16348030	16348050	16021535	16021555	72536	hg19					enhancer	enh				GACTCTCTACCTGACACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKA	direct	Highly Significant	NA				0.360776919									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1053	chr1	16375301	16375323	16048806	16048828	72537	hg19					enhancer	enh				GTTTGAAATCCACGTATGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	direct	Highly Significant	NA				0.30411802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1054	chr1	16375313	16375335	16048818	16048840	72538	hg19					enhancer	enh				GCCAACGGGCCAGGGTCATACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.669494216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1055	chr1	16375323	16375345	16048828	16048850	72539	hg19					enhancer	enh				GCTCAGAGAGGCCAACGGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.288985036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1056	chr1	16375324	16375345	16048829	16048850	72540	hg19					enhancer	enh				GCTCAGAGAGGCCAACGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.647082969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1057	chr1	16375329	16375350	16048834	16048855	72541	hg19					enhancer	enh				GCCGGGCTCAGAGAGGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-1.334694551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1058	chr1	16375330	16375350	16048835	16048855	72542	hg19					enhancer	enh				GCCGGGCTCAGAGAGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	direct	Highly Significant	NA				0.216402257									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1059	chr1	16375380	16375400	16048885	16048905	72543	hg19					enhancer	enh				GTCCCCACCCGATAGCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				0.020078809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1060	chr1	16375385	16375406	16048890	16048911	72544	hg19					enhancer	enh				GCGCCCTCTCGCTATCGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.189957529									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1061	chr1	16375438	16375460	16048943	16048965	72545	hg19					enhancer	enh				GCAGCGGGCTCCTCCCCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				0.139193285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1062	chr1	16375454	16375475	16048959	16048980	72546	hg19					enhancer	enh				GCAGGGCATGCGCCCTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.122822175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1063	chr1	16375459	16375480	16048964	16048985	72547	hg19					enhancer	enh				GGAGGGCAGGGCATGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.150175638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1064	chr1	16375459	16375479	16048964	16048984	72548	hg19					enhancer	enh				GAGGGCAGGGCATGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.117065248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1065	chr1	16375483	16375504	16048988	16049009	72549	hg19					enhancer	enh				GCCCGGACAGGGACAGACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	direct	Highly Significant	NA				0.260222524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1066	chr1	16375486	16375507	16048991	16049012	72550	hg19					enhancer	enh				GCAGCCCGGACAGGGACAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLCNKB	indirect	Non Significant	NA				-0.407209577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1067	chr1	17766042	17766062	17439546	17439566	72551	hg19					enhancer	enh				GGTTTCTCATCACTCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.887503215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1068	chr1	17766121	17766141	17439625	17439645	72552	hg19					enhancer	enh				GCTGGAGCCCTCGTCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.514070272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1069	chr1	17766121	17766142	17439625	17439646	72553	hg19					enhancer	enh				GGCTGGAGCCCTCGTCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.241498306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1070	chr1	17766121	17766143	17439625	17439647	72554	hg19					enhancer	enh				GGGCTGGAGCCCTCGTCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-1.156207909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1071	chr1	17766206	17766226	17439710	17439730	72555	hg19					enhancer	enh				GAAACACATGTGCGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.11671176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1072	chr1	17766224	17766245	17439728	17439749	72556	hg19					enhancer	enh				GCCGCGCGCTCGCTTGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.010137333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1073	chr1	17766283	17766305	17439787	17439809	72557	hg19					enhancer	enh				GCAACGGGTCCGCCGGCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	indirect	Non Significant	NA				-0.34530582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1074	chr1	17766288	17766309	17439792	17439813	72558	hg19					enhancer	enh				GCCGGCAACGGGTCCGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RCC2	direct	Highly Significant	NA				0.280007444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1075	chr1	20208731	20208752	19882238	19882259	72559	hg19					enhancer	enh				GTGGATGGTACTCAACGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.404339017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1076	chr1	20208812	20208833	19882319	19882340	72560	hg19					enhancer	enh				GCTCGCCGAGCCCCGCAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.407946062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1077	chr1	20208835	20208856	19882342	19882363	72561	hg19					enhancer	enh				GCGGGGATTCCATCATGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.738094006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1078	chr1	20208847	20208869	19882354	19882376	72562	hg19					enhancer	enh				GCCCAGCACCCCGGTCACATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				0.169610703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1079	chr1	20208883	20208904	19882390	19882411	72563	hg19					enhancer	enh				GGTTGCTGCGTAGTCGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.28597474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1080	chr1	20208883	20208903	19882390	19882410	72564	hg19					enhancer	enh				GGTTGCTGCGTAGTCGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.205449425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1081	chr1	20208884	20208904	19882391	19882411	72565	hg19					enhancer	enh				GTTGCTGCGTAGTCGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				0.023468008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1082	chr1	20208912	20208934	19882419	19882441	72566	hg19					enhancer	enh				GAAGGTAAAACAGCGCGGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				0.04576562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1083	chr1	20208918	20208939	19882425	19882446	72567	hg19					enhancer	enh				GTTGGGAAGGTAAAACAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.07109985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1084	chr1	20208919	20208939	19882426	19882446	72568	hg19					enhancer	enh				GTTGGGAAGGTAAAACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.487559674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1085	chr1	20208932	20208952	19882439	19882459	72569	hg19					enhancer	enh				GTCCGCCTCAAGCGTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.440811532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1086	chr1	20208932	20208954	19882439	19882461	72570	hg19					enhancer	enh				GCGTCCGCCTCAAGCGTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.222356603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1087	chr1	20208965	20208986	19882472	19882493	72571	hg19					enhancer	enh				GCGCCTTTCCCTCCTGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.426044052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1088	chr1	20208971	20208992	19882478	19882499	72572	hg19					enhancer	enh				GTCCCCAGCGGCAGGAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.563232268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1089	chr1	20208980	20209001	19882487	19882508	72573	hg19					enhancer	enh				GCCGCTGGGGACTGCAGGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.092705627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1090	chr1	20208997	20209019	19882504	19882526	72574	hg19					enhancer	enh				GCTAAGGCCATGTCCCGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.35981368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1091	chr1	20209053	20209075	19882560	19882582	72575	hg19					enhancer	enh				GAAAGCCGAGGCCGAGCGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.120778376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1092	chr1	20209061	20209081	19882568	19882588	72576	hg19					enhancer	enh				GTCCCGCTTGCGCTCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	indirect	Non Significant	NA				-0.02805361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1093	chr1	20209067	20209089	19882574	19882596	72577	hg19					enhancer	enh				GCCCGCTCGTCCCGCTTGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OTUD3	direct	Highly Significant	NA				0.404592879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1094	chr1	20512564	20512585	20186071	20186092	72578	hg19					enhancer	enh				GGTCTCCCGGGCAACGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	direct	Highly Significant	NA				0.823635108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1095	chr1	20512564	20512584	20186071	20186091	72579	hg19					enhancer	enh				GTCTCCCGGGCAACGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.037722197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1096	chr1	20512579	20512601	20186086	20186108	72580	hg19					enhancer	enh				GAGACCAGGGTTGTTTACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				0.137374763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1097	chr1	20512581	20512601	20186088	20186108	72581	hg19					enhancer	enh				GACCAGGGTTGTTTACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.360686027									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1098	chr1	20512586	20512606	20186093	20186113	72582	hg19					enhancer	enh				GTCCTGCTGGTAAACAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.104994452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1099	chr1	20512591	20512613	20186098	20186120	72583	hg19					enhancer	enh				GTTTACCAGCAGGACAGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.077935939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1100	chr1	20512591	20512612	20186098	20186119	72584	hg19					enhancer	enh				GTTTACCAGCAGGACAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.291963638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1101	chr1	20512599	20512619	20186106	20186126	72585	hg19					enhancer	enh				GCAGGACAGAGCCCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	direct	Highly Significant	NA				1.711077398									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1102	chr1	20512599	20512619	20186106	20186126	72586	hg19					enhancer	enh				GCGCCCGGGCTCTGTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				0.13683835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1103	chr1	20512614	20512635	20186121	20186142	72587	hg19					enhancer	enh				GCTCCATCCGCCGCCTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.137458352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1104	chr1	20512624	20512644	20186131	20186151	72588	hg19					enhancer	enh				GCGGATGGAGCGGAACGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				0.118863191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-2343	chr1	20512633	20512653	20186140	20186160	72589	hg19	N/A	N/A	N/A	Enhatls2601	enhancer	enh				GCGGAACGGCTAGGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.171360994	PLA2G2C	chr1	20161252	20186518	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2342
enhrx-2343	chr1	20512633	20512653	20186140	20186160	72590	hg19	N/A	N/A	N/A	Enhatls2601	enhancer	enh				GCGGAACGGCTAGGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-0.171360994	UBXN10	chr1	20186095	20196050	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2342
enhrx-2343	chr1	20512662	20512684	20186169	20186191	72591	hg19	N/A	N/A	N/A	Enhatls2601	enhancer	enh				GCCAAGGGCAGGCCGCGGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-1.400647137	PLA2G2C	chr1	20161252	20186518	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2342
enhrx-2343	chr1	20512662	20512684	20186169	20186191	72592	hg19	N/A	N/A	N/A	Enhatls2601	enhancer	enh				GCCAAGGGCAGGCCGCGGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UBXN10	indirect	Non Significant	NA				-1.400647137	UBXN10	chr1	20186095	20196050	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2342
enhrx-lit1105	chr1	20812684	20812705	20486191	20486212	72593	hg19					enhancer	enh				GCGAGCTGCGAGGAGAAATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	direct	Highly Significant	NA				0.521347647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1106	chr1	20812691	20812711	20486198	20486218	72594	hg19					enhancer	enh				GCGAGGAGAAATGCCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				0.050527093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1107	chr1	20812698	20812719	20486205	20486226	72595	hg19					enhancer	enh				GAAATGCCGGCCGCGGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				-0.086100761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1108	chr1	20812768	20812788	20486275	20486295	72596	hg19					enhancer	enh				GATCTCTCCCCGAGGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				-0.081053551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1109	chr1	20812769	20812789	20486276	20486296	72597	hg19					enhancer	enh				GGATCTCTCCCCGAGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				-0.168703849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1110	chr1	20812790	20812810	20486297	20486317	72598	hg19					enhancer	enh				GTGACGTCGCTCCGCTCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				0.176530526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1111	chr1	20812800	20812820	20486307	20486327	72599	hg19					enhancer	enh				GCGACGTCACGGGGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	direct	Highly Significant	NA				0.345744589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1112	chr1	20812871	20812893	20486378	20486400	72600	hg19					enhancer	enh				GTCCCGCTCACGGGTGTTTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	direct	Highly Significant	NA				0.358440575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1113	chr1	20812876	20812897	20486383	20486404	72601	hg19					enhancer	enh				GCCCCGTAAACACCCGTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				-0.440073599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1114	chr1	20812884	20812904	20486391	20486411	72602	hg19					enhancer	enh				GTGTTTACGGGGCCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAMK2N1	indirect	Non Significant	NA				-1.319885997									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1115	chr1	23695413	23695434	23368920	23368941	72603	hg19					enhancer	enh				GTACGCAATACAACTCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.029709999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1116	chr1	23695452	23695474	23368959	23368981	72604	hg19					enhancer	enh				GCACTCCCGAGTCGCCCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.155588892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1117	chr1	23695457	23695478	23368964	23368985	72605	hg19					enhancer	enh				GACCGCACTCCCGAGTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.276716715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1118	chr1	23695468	23695490	23368975	23368997	72606	hg19					enhancer	enh				GAGTGCGGTCGGCAGTAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.29709482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1119	chr1	23695470	23695490	23368977	23368997	72607	hg19					enhancer	enh				GTGCGGTCGGCAGTAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-1.554836326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1120	chr1	23695472	23695493	23368979	23369000	72608	hg19					enhancer	enh				GCGGTCGGCAGTAGAGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.019496864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1121	chr1	23695491	23695511	23368998	23369018	72609	hg19					enhancer	enh				GCCGAAGCCAAGACACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.270928429									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1122	chr1	23695491	23695513	23368998	23369020	72610	hg19					enhancer	enh				GCGCCGAAGCCAAGACACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.413933732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1123	chr1	23695521	23695543	23369028	23369050	72611	hg19					enhancer	enh				GACGCAGTCGCACGCCCCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.333887308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1124	chr1	23695522	23695543	23369029	23369050	72612	hg19					enhancer	enh				GACGCAGTCGCACGCCCCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.690722333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1125	chr1	23695530	23695552	23369037	23369059	72613	hg19					enhancer	enh				GTGCGACTGCGTCCTTCTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.161114362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1126	chr1	23695532	23695552	23369039	23369059	72614	hg19					enhancer	enh				GCGACTGCGTCCTTCTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.151307552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1127	chr1	23695557	23695579	23369064	23369086	72615	hg19					enhancer	enh				GCCCCTCGAGCGGCGGGCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-1.079366045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1128	chr1	23695561	23695583	23369068	23369090	72616	hg19					enhancer	enh				GCCACTCAGCCCGCCGCTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.015359965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1129	chr1	23695573	23695594	23369080	23369101	72617	hg19					enhancer	enh				GCTGAGTGGCGTCCAGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.272831973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1130	chr1	23695588	23695609	23369095	23369116	72618	hg19					enhancer	enh				GCGGCGGGGAGGCGAAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-1.494024013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1131	chr1	23695639	23695661	23369146	23369168	72619	hg19					enhancer	enh				GGCGTGTAAGGAGGAGATAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.053007742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1132	chr1	23695640	23695661	23369147	23369168	72620	hg19					enhancer	enh				GCGTGTAAGGAGGAGATAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.079564362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1133	chr1	23695651	23695673	23369158	23369180	72621	hg19					enhancer	enh				GGAGATAGCCAGGCCCCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.186580296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1134	chr1	23695652	23695673	23369159	23369180	72622	hg19					enhancer	enh				GAGATAGCCAGGCCCCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.266416266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1135	chr1	23695652	23695672	23369159	23369179	72623	hg19					enhancer	enh				GAGATAGCCAGGCCCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-1.068047703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1136	chr1	23695680	23695701	23369187	23369208	72624	hg19					enhancer	enh				GGGCCCTCCTTAGCGTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.635848707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1137	chr1	23695681	23695701	23369188	23369208	72625	hg19					enhancer	enh				GGCCCTCCTTAGCGTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.23737709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1138	chr1	23695690	23695711	23369197	23369218	72626	hg19					enhancer	enh				GACAAGCCCTCTGGGACGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.271389988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1139	chr1	23695708	23695729	23369215	23369236	72627	hg19					enhancer	enh				GTCTGCTACAGGGGCTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.246266297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1140	chr1	23695731	23695753	23369238	23369260	72628	hg19					enhancer	enh				GCCTCCCGCACCGAAGGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.508952278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1141	chr1	23695738	23695758	23369245	23369265	72629	hg19					enhancer	enh				GCCCAGGGTCCCTTCGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.192064766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1142	chr1	23695739	23695761	23369246	23369268	72630	hg19					enhancer	enh				GACGCCCAGGGTCCCTTCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.354922992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1143	chr1	23695753	23695774	23369260	23369281	72631	hg19					enhancer	enh				GATCAGGGCCTCAGACGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	direct	Highly Significant	NA				0.27707763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1144	chr1	23695758	23695778	23369265	23369285	72632	hg19					enhancer	enh				GTCTGAGGCCCTGATCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				0.128439922									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1145	chr1	23695776	23695798	23369283	23369305	72633	hg19					enhancer	enh				GCTAACATCCTGAAGGCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf213	indirect	Non Significant	NA				-0.143890463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1146	chr1	24194602	24194622	23868112	23868132	72634	hg19					enhancer	enh				GAACTTGGCTTCGTCGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				0.098662854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1147	chr1	24194679	24194700	23868189	23868210	72635	hg19					enhancer	enh				GCTGGGCCCGACGCACCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.24419341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1148	chr1	24194688	24194709	23868198	23868219	72636	hg19					enhancer	enh				GAGCGGCCGAGTCGGTGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.563027637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1149	chr1	24194706	24194726	23868216	23868236	72637	hg19					enhancer	enh				GCTGCTGCTCTTCCTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.201222987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1150	chr1	24194724	24194746	23868234	23868256	72638	hg19					enhancer	enh				GCAGCAACAGCGCGGGACCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.36073555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1151	chr1	24194744	24194764	23868254	23868274	72639	hg19					enhancer	enh				GCCGGCCGCGACCTCATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.237726237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1152	chr1	24194764	24194784	23868274	23868294	72640	hg19					enhancer	enh				GGGTAGCGATGCGGGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.422837017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1153	chr1	24194772	24194793	23868282	23868303	72641	hg19					enhancer	enh				GTCGCTGAGGGGTAGCGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.249916855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1154	chr1	24194772	24194794	23868282	23868304	72642	hg19					enhancer	enh				GCATCGCTACCCCTCAGCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				0.08391665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1155	chr1	24194784	24194804	23868294	23868314	72643	hg19					enhancer	enh				GAGTGGGCCGCGTCGCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.02492859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1156	chr1	24194793	24194813	23868303	23868323	72644	hg19					enhancer	enh				GCGGCCCACTCTTAACGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.353544017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1157	chr1	24194800	24194820	23868310	23868330	72645	hg19					enhancer	enh				GGCACCTGCGCGTTAAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.004704641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1158	chr1	24194800	24194821	23868310	23868331	72646	hg19					enhancer	enh				GGGCACCTGCGCGTTAAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				-0.318161761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1159	chr1	24194801	24194821	23868311	23868331	72647	hg19					enhancer	enh				GGGCACCTGCGCGTTAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	direct	Highly Significant	NA				0.291628606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1160	chr1	24194838	24194858	23868348	23868368	72648	hg19					enhancer	enh				GGGCCAATCGTTAGTCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FUCA1	indirect	Non Significant	NA				0.091268148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1161	chr1	25664790	25664812	25338299	25338321	72649	hg19					enhancer	enh				GTGTCCGCATGCGCGACTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				0.037619798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1162	chr1	25664792	25664813	25338301	25338322	72650	hg19					enhancer	enh				GTCCGCATGCGCGACTGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				0.046692656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1163	chr1	25664792	25664812	25338301	25338321	72651	hg19					enhancer	enh				GTCCGCATGCGCGACTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	direct	Highly Significant	NA				0.609911789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1164	chr1	25664796	25664816	25338305	25338325	72652	hg19					enhancer	enh				GCATGCGCGACTGAGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.06283152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1165	chr1	25664800	25664820	25338309	25338329	72653	hg19					enhancer	enh				GCGCGACTGAGCCGGGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.790717973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1166	chr1	25664814	25664836	25338323	25338345	72654	hg19					enhancer	enh				GGATGCAGCAGTACCATCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				0.010470101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1167	chr1	25664814	25664835	25338323	25338344	72655	hg19					enhancer	enh				GATGCAGCAGTACCATCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.20963295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1168	chr1	25664815	25664835	25338324	25338344	72656	hg19					enhancer	enh				GTGGATGGTACTGCTGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	direct	Highly Significant	NA				0.313920123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1169	chr1	25664830	25664852	25338339	25338361	72657	hg19					enhancer	enh				GCATCCGGGTGTCTGGAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.403891879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1170	chr1	25664837	25664857	25338346	25338366	72658	hg19					enhancer	enh				GGCCACAGCCTCCAGACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	direct	Highly Significant	NA				0.297044828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1171	chr1	25664899	25664920	25338408	25338429	72659	hg19					enhancer	enh				GAGCCCGGTGTCGCGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	direct	Highly Significant	NA				0.200574631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1172	chr1	25664899	25664920	25338408	25338429	72660	hg19					enhancer	enh				GCGCGGCGCGACACCGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.09367011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1173	chr1	25664916	25664938	25338425	25338447	72661	hg19					enhancer	enh				GCTCCGGAACCACTGCACGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.281272317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1174	chr1	25664916	25664936	25338425	25338445	72662	hg19					enhancer	enh				GCTCCGGAACCACTGCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.26190666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1175	chr1	25664922	25664942	25338431	25338451	72663	hg19					enhancer	enh				GAACCACTGCACGACGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				0.108710329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-2937	chr1	25664939	25664959	25338448	25338468	72664	hg19	N/A	N/A	N/A	Enhatls3268	enhancer	enh				GGCTGGACGTAAGTGTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.136292901	TMEM50A	chr1	25338333	25362361	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2936
enhrx-2937	chr1	25664970	25664990	25338479	25338499	72665	hg19	N/A	N/A	N/A	Enhatls3268	enhancer	enh				GGTAAGAGAGTAGCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.175601363	TMEM50A	chr1	25338333	25362361	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2936
enhrx-2937	chr1	25664992	25665013	25338501	25338522	72666	hg19	N/A	N/A	N/A	Enhatls3268	enhancer	enh				GCTGGAGAGGCCTCGGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM50A	indirect	Non Significant	NA				-0.324004002	TMEM50A	chr1	25338333	25362361	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2936
enhrx-lit1176	chr1	26126514	26126535	25800023	25800044	72667	hg19					enhancer	enh				GCTGATCGCGTCTATGCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.211134389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1177	chr1	26126537	26126558	25800046	25800067	72668	hg19					enhancer	enh				GCTACACCGGAACGCCAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.077731727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1178	chr1	26126572	26126593	25800081	25800102	72669	hg19					enhancer	enh				GCTCTGGCCGGGCTGCGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.582099058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1179	chr1	26126582	26126604	25800091	25800113	72670	hg19					enhancer	enh				GCTGGTTCCCGGCTTCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.727054734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1180	chr1	26126670	26126690	25800179	25800199	72671	hg19					enhancer	enh				GCCCCGCTCTTTCGCTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.147029523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1181	chr1	26126674	26126695	25800183	25800204	72672	hg19					enhancer	enh				GGCCCGGGAAGCGAAAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				1.128730209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1182	chr1	26126674	26126694	25800183	25800203	72673	hg19					enhancer	enh				GCCCGGGAAGCGAAAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.883651346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1183	chr1	26126676	26126697	25800185	25800206	72674	hg19					enhancer	enh				GCGGCCCGGGAAGCGAAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.462725208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1184	chr1	26126702	26126723	25800211	25800232	72675	hg19					enhancer	enh				GCCGCCGCCAGCCGCAGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				0.287617683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1185	chr1	26126706	26126727	25800215	25800236	72676	hg19					enhancer	enh				GCCCATGGCTGCGGCTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				0.204082433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1186	chr1	26126712	26126733	25800221	25800242	72677	hg19					enhancer	enh				GGCCCGGCCCATGGCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				0.401945278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1187	chr1	26126712	26126732	25800221	25800241	72678	hg19					enhancer	enh				GCCCGGCCCATGGCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				0.236486451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1188	chr1	26126739	26126760	25800248	25800269	72679	hg19					enhancer	enh				GCTGGGCGGCCCGCGTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	direct	Highly Significant	NA				0.203063168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1189	chr1	26126854	26126874	25800363	25800383	72680	hg19					enhancer	enh				GCGGGCGCAGACCCGGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEPN1	indirect	Non Significant	NA				-0.552927332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1190	chr1	26188540	26188560	25862049	25862069	72681	hg19					enhancer	enh				GTCATCTTGCATTGATCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	direct	Highly Significant	NA				0.623463905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1191	chr1	26188548	26188569	25862057	25862078	72682	hg19					enhancer	enh				GCATTGATCCACAGGGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.269145465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1192	chr1	26188559	26188580	25862068	25862089	72683	hg19					enhancer	enh				GCAGGTCACCACTGGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				0.121154544									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1193	chr1	26188567	26188588	25862076	25862097	72684	hg19					enhancer	enh				GCTCAGAGGCAGGTCACCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	direct	Highly Significant	NA				0.389845831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1194	chr1	26188582	26188603	25862091	25862112	72685	hg19					enhancer	enh				GTTTCCTGGGCCTCTGCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.198816242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1195	chr1	26188589	26188609	25862098	25862118	72686	hg19					enhancer	enh				GAGGCCCAGGAAACACTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.074470898									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1196	chr1	26188610	26188630	25862119	25862139	72687	hg19					enhancer	enh				GGATAAATGAATCCGTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-1.121298977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1197	chr1	26188618	26188638	25862127	25862147	72688	hg19					enhancer	enh				GAATCCGTAACAAGGGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.009612955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1198	chr1	26188644	26188664	25862153	25862173	72689	hg19					enhancer	enh				GAAGCTGGGAACAGGCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.041951696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1199	chr1	26188662	26188684	25862171	25862193	72690	hg19					enhancer	enh				GCTCTGGCTTCTGTGTCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				-0.343469893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1200	chr1	26188673	26188693	25862182	25862202	72691	hg19					enhancer	enh				GAAGCCAGAGCTAGGAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				0.161116234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1201	chr1	26188680	26188701	25862189	25862210	72692	hg19					enhancer	enh				GAGCCCCAGATCTCCTAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PAQR7	indirect	Non Significant	NA				0.073747937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1202	chr1	26438204	26438224	26111713	26111733	72693	hg19					enhancer	enh				GTCGGTGGCGCGGAACGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.861787957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1203	chr1	26438216	26438236	26111725	26111745	72694	hg19					enhancer	enh				GAACGTCCCGGCTCGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.508329346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1204	chr1	26438225	26438245	26111734	26111754	72695	hg19					enhancer	enh				GGCTTTCCGTAGCGCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.417104845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1205	chr1	26438274	26438294	26111783	26111803	72696	hg19					enhancer	enh				GGTGTGTCCGCGCGCACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.255434292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1206	chr1	26438296	26438317	26111805	26111826	72697	hg19					enhancer	enh				GGGCGCGCGCCGGCTGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.942667846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1207	chr1	26438297	26438317	26111806	26111826	72698	hg19					enhancer	enh				GGCGCGCGCCGGCTGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.902197455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1208	chr1	26438302	26438323	26111811	26111832	72699	hg19					enhancer	enh				GCGCCGGCTGCTGACTGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-2.685878195									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1209	chr1	26438308	26438330	26111817	26111839	72700	hg19					enhancer	enh				GCCGCCGCCTCCAGTCAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.400779979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1210	chr1	26438333	26438355	26111842	26111864	72701	hg19					enhancer	enh				GGAGGCGCGAGCTGCCCGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-1.264152818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1211	chr1	26438334	26438355	26111843	26111864	72702	hg19					enhancer	enh				GAGGCGCGAGCTGCCCGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-1.4751215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1212	chr1	26438357	26438378	26111866	26111887	72703	hg19					enhancer	enh				GCGGCCTGCAGAGCCCATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-1.222530118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1213	chr1	26438359	26438379	26111868	26111888	72704	hg19					enhancer	enh				GGCCTGCAGAGCCCATGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.753495639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1214	chr1	26438374	26438394	26111883	26111903	72705	hg19					enhancer	enh				GCTGCCGCTTCTCCCTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-1.274961893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1215	chr1	26438383	26438404	26111892	26111913	72706	hg19					enhancer	enh				GAAGCGGCAGCGTCTACCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.684711981									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3041	chr1	26438392	26438413	26111901	26111922	72707	hg19	N/A	N/A	N/A	Enhatls3379	enhancer	enh				GCGTCTACCCTGAGGTAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.698027133	PDIK1L	chr1	26111164	26125555	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3040
enhrx-3041	chr1	26438406	26438426	26111915	26111935	72708	hg19	N/A	N/A	N/A	Enhatls3379	enhancer	enh				GTAAATCTGGCCTTTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIK1L	indirect	Non Significant	NA				-0.483512402	PDIK1L	chr1	26111164	26125555	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3040
enhrx-lit1216	chr1	27216576	27216597	26890085	26890106	72709	hg19					enhancer	enh				GCCCCTGCCATTGGCGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.126452755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1217	chr1	27216581	27216601	26890090	26890110	72710	hg19					enhancer	enh				GCCGCGGGCCGCCAATGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.876933544									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1218	chr1	27216599	27216621	26890108	26890130	72711	hg19					enhancer	enh				GCCCGGAGCAGGTCAACTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.656666502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1219	chr1	27216610	27216630	26890119	26890139	72712	hg19					enhancer	enh				GTCAACTCACAGGGAAAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-1.366713957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1220	chr1	27216643	27216665	26890152	26890174	72713	hg19					enhancer	enh				GCCCTCAGTCTCGTCTCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-1.489114498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1221	chr1	27216675	27216697	26890184	26890206	72714	hg19					enhancer	enh				GCCGCCAACGAGGTATACGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-1.314111357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1222	chr1	27216687	27216708	26890196	26890217	72715	hg19					enhancer	enh				GAGTGACGCTGGCCGCCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				0.040721426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1223	chr1	27216691	27216713	26890200	26890222	72716	hg19					enhancer	enh				GGCGGCCAGCGTCACTCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-1.390957871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1224	chr1	27216692	27216713	26890201	26890222	72717	hg19					enhancer	enh				GCGGCCAGCGTCACTCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-4.012330442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1225	chr1	27216695	27216716	26890204	26890225	72718	hg19					enhancer	enh				GCCAGCGTCACTCGCCTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-2.92711127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1226	chr1	27216712	27216732	26890221	26890241	72719	hg19					enhancer	enh				GGTCTCAGCTGTTCCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-5.376618419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1227	chr1	27216723	27216744	26890232	26890253	72720	hg19					enhancer	enh				GCTGAGACCGTGTCGCGCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.325185082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1228	chr1	27216732	27216754	26890241	26890263	72721	hg19					enhancer	enh				GTGTCGCGCAAAAGGAGATAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-5.015519584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1229	chr1	27216734	27216754	26890243	26890263	72722	hg19					enhancer	enh				GTCGCGCAAAAGGAGATAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-3.81482763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1230	chr1	27216779	27216801	26890288	26890310	72723	hg19					enhancer	enh				GACTTCCGGACAGCGTCGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.74571961									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1231	chr1	27216796	27216816	26890305	26890325	72724	hg19					enhancer	enh				GGAAACGGCGAGCCAACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-1.080386513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1232	chr1	27216838	27216858	26890347	26890367	72725	hg19					enhancer	enh				GGGACGAAGCTAGACGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				0.13101756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1233	chr1	27216873	27216895	26890382	26890404	72726	hg19					enhancer	enh				GCCGCATTTCTCTCGCGGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPN2	indirect	Non Significant	NA				-0.054899394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1234	chr1	27719024	27719045	27392520	27392541	72727	hg19					enhancer	enh				GCGTTGCGCGGCATAGTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.245060781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1235	chr1	27719066	27719086	27392562	27392582	72728	hg19					enhancer	enh				GTCCGATCAGCCAATGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.540059934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1236	chr1	27719071	27719093	27392567	27392589	72729	hg19					enhancer	enh				GTCAGCGGTCCGATCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	direct	Highly Significant	NA				0.220355306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1237	chr1	27719083	27719103	27392579	27392599	72730	hg19					enhancer	enh				GACCGCTGACGTCACCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.003488842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1238	chr1	27719090	27719110	27392586	27392606	72731	hg19					enhancer	enh				GACGTCACCGAACCGGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.217055096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1239	chr1	27719125	27719147	27392621	27392643	72732	hg19					enhancer	enh				GTGACTCACGCCGCTTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				0.013551093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1240	chr1	27719127	27719147	27392623	27392643	72733	hg19					enhancer	enh				GACTCACGCCGCTTCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				0.001197917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1241	chr1	27719134	27719155	27392630	27392651	72734	hg19					enhancer	enh				GCCGCTTCTCCCGCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	direct	Highly Significant	NA				0.267094292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1242	chr1	27719182	27719202	27392678	27392698	72735	hg19					enhancer	enh				GCTCGGGTCCTGGCGGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	direct	Highly Significant	NA				0.204726238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1243	chr1	27719192	27719212	27392688	27392708	72736	hg19					enhancer	enh				GGGAGGCTCCGCTCGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				0.007195109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1244	chr1	27719192	27719213	27392688	27392709	72737	hg19					enhancer	enh				GGGGAGGCTCCGCTCGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.156868598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1245	chr1	27719198	27719218	27392694	27392714	72738	hg19					enhancer	enh				GCCGCGGGGAGGCTCCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.553608534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1246	chr1	27719199	27719219	27392695	27392715	72739	hg19					enhancer	enh				GGCCGCGGGGAGGCTCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.418203533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1247	chr1	27719220	27719240	27392716	27392736	72740	hg19					enhancer	enh				GCTCAGGACCAGGCGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	direct	Highly Significant	NA				0.443465384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3272	chr1	27719230	27719250	27392726	27392746	72741	hg19	N/A	N/A	N/A	Enhatls3630	enhancer	enh				GCTACTCACCGCTCAGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.283728761	GPR3	chr1	27392621	27395814	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3271
enhrx-3272	chr1	27719236	27719256	27392732	27392752	72742	hg19	N/A	N/A	N/A	Enhatls3630	enhancer	enh				GGGCCCGCTACTCACCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-0.136283094	GPR3	chr1	27392621	27395814	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3271
enhrx-3272	chr1	27719241	27719261	27392737	27392757	72743	hg19	N/A	N/A	N/A	Enhatls3630	enhancer	enh				GTGAGTAGCGGGCCCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	indirect	Non Significant	NA				-1.215692438	GPR3	chr1	27392621	27395814	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3271
enhrx-3272	chr1	27719332	27719352	27392828	27392848	72744	hg19	N/A	N/A	N/A	Enhatls3630	enhancer	enh				GCCGGGGTTCGAGTTCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR3	direct	Highly Significant	NA				0.236307281	GPR3	chr1	27392621	27395814	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3271
enhrx-lit1248	chr1	27816506	27816528	27489995	27490017	72745	hg19					enhancer	enh				GCAGTCGCCGTCAGCGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.038189219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1249	chr1	27816573	27816595	27490062	27490084	72746	hg19					enhancer	enh				GACCGCCTCGCGGGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				0.008617575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1250	chr1	27816578	27816599	27490067	27490088	72747	hg19					enhancer	enh				GCCGTTTGGCAGCCCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.769029469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1251	chr1	27816631	27816651	27490120	27490140	72748	hg19					enhancer	enh				GGACACAGGCAGGGCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	direct	Highly Significant	NA				0.569399452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1252	chr1	27816631	27816653	27490120	27490142	72749	hg19					enhancer	enh				GCGGACACAGGCAGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.466475662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1253	chr1	27816640	27816661	27490129	27490150	72750	hg19					enhancer	enh				GCGTAATGGCGGACACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				0.017668168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1254	chr1	27816645	27816667	27490134	27490156	72751	hg19					enhancer	enh				GGAATCGCGTAATGGCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.590663217									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1255	chr1	27816645	27816666	27490134	27490155	72752	hg19					enhancer	enh				GAATCGCGTAATGGCGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.083067393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1256	chr1	27816651	27816673	27490140	27490162	72753	hg19					enhancer	enh				GCCATTACGCGATTCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				0.036593017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1257	chr1	27816652	27816672	27490141	27490161	72754	hg19					enhancer	enh				GGCGGGGAATCGCGTAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	direct	Highly Significant	NA				0.583593568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1258	chr1	27816652	27816673	27490141	27490162	72755	hg19					enhancer	enh				GGGCGGGGAATCGCGTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	direct	Highly Significant	NA				0.253115662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1259	chr1	27816668	27816690	27490157	27490179	72756	hg19					enhancer	enh				GGTGTGGCTGCCGCCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	direct	Highly Significant	NA				0.259293351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1260	chr1	27816668	27816689	27490157	27490178	72757	hg19					enhancer	enh				GTGTGGCTGCCGCCCAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	direct	Highly Significant	NA				1.262589655									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1261	chr1	27816675	27816697	27490164	27490186	72758	hg19					enhancer	enh				GGCGGCAGCCACACCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				0.050958837									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1262	chr1	27816676	27816697	27490165	27490186	72759	hg19					enhancer	enh				GCGGCAGCCACACCCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.61753527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1263	chr1	27816691	27816713	27490180	27490202	72760	hg19					enhancer	enh				GAGCCAATCAGGGCCATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-1.139287394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1264	chr1	27816691	27816711	27490180	27490200	72761	hg19					enhancer	enh				GCCAATCAGGGCCATTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.64100115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1265	chr1	27816696	27816718	27490185	27490207	72762	hg19					enhancer	enh				GCAGTGAGCCAATCAGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				0.029020946									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1266	chr1	27816820	27816840	27490309	27490329	72763	hg19					enhancer	enh				GATTGCGGAAGTCGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WASF2	indirect	Non Significant	NA				-0.247111049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3280	chr1	27902540	27902560	27576029	27576049	72764	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GGGGTTATTAATAGCGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.109384898	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902557	27902579	27576046	27576068	72765	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCTGGCTCGGGCAGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.005819934	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902580	27902601	27576069	27576090	72766	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCGTGCAGGTAGCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.503259778	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902595	27902617	27576084	27576106	72767	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCTCTCTGCAGGAGGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.803168269	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902599	27902619	27576088	27576108	72768	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCCCTCCTGCAGAGAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				0.017967011	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902603	27902623	27576092	27576112	72769	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCAGTGCTCTCTGCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				0.137211621	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902605	27902626	27576094	27576115	72770	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCGCCAGTGCTCTCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.138092788	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902608	27902628	27576097	27576117	72771	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GGGCCGCCAGTGCTCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.093202786	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902623	27902644	27576112	27576133	72772	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GGCCCGGCGCTCCCTCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.061456188	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902624	27902644	27576113	27576133	72773	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCCGGCGCTCCCTCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.018766258	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902638	27902658	27576127	27576147	72774	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCCTCAGTCCGCCGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	direct	Highly Significant	NA				0.206080856	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902641	27902663	27576130	27576152	72775	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GTTAGGCCTCAGTCCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.369457055	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902643	27902663	27576132	27576152	72776	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GCGGCGGACTGAGGCCTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.112638503	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902664	27902686	27576153	27576175	72777	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GGATAGCGCCACCGTGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	direct	Highly Significant	NA				0.275934399	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902665	27902686	27576154	27576175	72778	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GATAGCGCCACCGTGAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	indirect	Non Significant	NA				-0.084496978	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902675	27902697	27576164	27576186	72779	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GTGATTGGCCGCCGGTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	direct	Highly Significant	NA				0.210094228	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-3280	chr1	27902675	27902695	27576164	27576184	72780	hg19	N/A	enh11668	N/A	Enhatls3645	enhancer	enh				GATTGGCCGCCGGTTCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHDC1	direct	Highly Significant	NA				0.360691437	AHDC1	chr1	27534034	27604177	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3279
enhrx-lit1267	chr1	28879547	28879567	28553035	28553055	72781	hg19					enhancer	enh				GCCCGCGCGGGCGCCAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				0.086213604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1268	chr1	28879559	28879580	28553047	28553068	72782	hg19					enhancer	enh				GCGGGGCTCGAAGGCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-0.129617622									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1269	chr1	28879569	28879589	28553057	28553077	72783	hg19					enhancer	enh				GCTCTGCGGGCGGGGCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				0.158687653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1270	chr1	28879582	28879603	28553070	28553091	72784	hg19					enhancer	enh				GCTTTGCGGGCGGGGCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-2.738385977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1271	chr1	28879596	28879617	28553084	28553105	72785	hg19					enhancer	enh				GCAAAGCCCCACCCCGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-0.020549966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1272	chr1	28879605	28879627	28553093	28553115	72786	hg19					enhancer	enh				GCCATACCCGCGCACCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-1.538591785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1273	chr1	28879611	28879631	28553099	28553119	72787	hg19					enhancer	enh				GGCCGCCATACCCGCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-0.464333606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1274	chr1	28879612	28879634	28553100	28553122	72788	hg19					enhancer	enh				GCTGGCCGCCATACCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-0.078262185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1275	chr1	28879620	28879642	28553108	28553130	72789	hg19					enhancer	enh				GTATGGCGGCCAGCCTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				0.085525742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3412	chr1	28879646	28879668	28553134	28553156	72790	hg19	N/A	N/A	N/A	Enhatls3784	enhancer	enh				GACGTGAGTGAGGGCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				0.069128019	TRNAU1AP	chr1	28553084	28578545	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3411
enhrx-3412	chr1	28879649	28879670	28553137	28553158	72791	hg19	N/A	N/A	N/A	Enhatls3784	enhancer	enh				GTGAGTGAGGGCAGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-3.105076419	TRNAU1AP	chr1	28553084	28578545	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3411
enhrx-3412	chr1	28879662	28879683	28553150	28553171	72792	hg19	N/A	N/A	N/A	Enhatls3784	enhancer	enh				GCCGTCCGGGGTCTGAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				0.193247205	TRNAU1AP	chr1	28553084	28578545	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3411
enhrx-3412	chr1	28879688	28879708	28553176	28553196	72793	hg19	N/A	N/A	N/A	Enhatls3784	enhancer	enh				GCATCTCGGTTTCGCGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRNAU1AP	indirect	Non Significant	NA				-0.763201883	TRNAU1AP	chr1	28553084	28578545	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3411
enhrx-lit1276	chr1	28918976	28918996	28592464	28592484	72794	hg19					enhancer	enh				GGGCGCGGACAAAACCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.215699111									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1277	chr1	28918983	28919005	28592471	28592493	72795	hg19					enhancer	enh				GACAAAACCGCCGCGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.006024183									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1278	chr1	28919103	28919124	28592591	28592612	72796	hg19					enhancer	enh				GAGCTACGTGGCAGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				0.139765412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1279	chr1	28919142	28919163	28592630	28592651	72797	hg19					enhancer	enh				GCCCGAGCCCGAGCCCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.217914104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1280	chr1	28919146	28919167	28592634	28592655	72798	hg19					enhancer	enh				GCCCACCGTGGGCTCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.48761273									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1281	chr1	28919187	28919209	28592675	28592697	72799	hg19					enhancer	enh				GCTGCAGCTGCGGGCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-1.280531924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1282	chr1	28919204	28919225	28592692	28592713	72800	hg19					enhancer	enh				GTTGCAGCTTGACCCGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.29882397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1283	chr1	28919205	28919227	28592693	28592715	72801	hg19					enhancer	enh				GCCGCGGGTCAAGCTGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.452071483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1284	chr1	28919217	28919238	28592705	28592726	72802	hg19					enhancer	enh				GCTGCAACTCTGGGACACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.299903967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1285	chr1	28919239	28919260	28592727	28592748	72803	hg19					enhancer	enh				GGCCACGAGCGCTTCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.292160705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1286	chr1	28919240	28919260	28592728	28592748	72804	hg19					enhancer	enh				GCCACGAGCGCTTCAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				0.082359666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3422	chr1	28919247	28919267	28592735	28592755	72805	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCGCTTCAGGTGCGGGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				0.078468163	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919247	28919267	28592735	28592755	72806	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCGCTTCAGGTGCGGGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				0.078468163	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919249	28919269	28592737	28592757	72807	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCTTCAGGTGCGGGTAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.204489222	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919249	28919269	28592737	28592757	72808	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCTTCAGGTGCGGGTAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	direct	Highly Significant	NA				0.204489222	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919271	28919292	28592759	28592780	72809	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCGCGGGAGGGACTTCTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.05545218	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919271	28919292	28592759	28592780	72810	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCGCGGGAGGGACTTCTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.05545218	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919300	28919320	28592788	28592808	72811	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GGTGAGCGTGCTTTAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.411870695	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919300	28919320	28592788	28592808	72812	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GGTGAGCGTGCTTTAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.411870695	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919320	28919342	28592808	28592830	72813	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GTTGGCCTCTCGGGAGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.148774787	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919320	28919342	28592808	28592830	72814	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GTTGGCCTCTCGGGAGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.148774787	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919336	28919357	28592824	28592845	72815	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCCAACTCAGAGGTCAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.105755773	TAF12	chr1	28587828	28648291	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-3422	chr1	28919336	28919357	28592824	28592845	72816	hg19	N/A	N/A	N/A	Enhatls3795	enhancer	enh				GCCAACTCAGAGGTCAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB42	indirect	Non Significant	NA				-0.105755773	RAB42	chr1	28592199	28595449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3421
enhrx-lit1287	chr1	28995120	28995140	28668608	28668628	72817	hg19					enhancer	enh				GAAAGAATTCTGCTTAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	direct	Highly Significant	NA				0.595211631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1288	chr1	28995155	28995175	28668643	28668663	72818	hg19					enhancer	enh				GGCTAAGGTTAATCCTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	direct	Highly Significant	NA				0.953811813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1289	chr1	28995171	28995193	28668659	28668681	72819	hg19					enhancer	enh				GTCCCTATTGCCGGTCCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				0.012743204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1290	chr1	28995201	28995223	28668689	28668711	72820	hg19					enhancer	enh				GCCGGAGAGCTGGCGCCTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.41262907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1291	chr1	28995207	28995228	28668695	28668716	72821	hg19					enhancer	enh				GCGCCAGCTCTCCGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	direct	Highly Significant	NA				0.230582699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1292	chr1	28995227	28995248	28668715	28668736	72822	hg19					enhancer	enh				GCGGCCGGAAGTGTTGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.630166474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1293	chr1	28995233	28995253	28668721	28668741	72823	hg19					enhancer	enh				GGAAGTGTTGAAGCCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.019720078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1294	chr1	28995239	28995259	28668727	28668747	72824	hg19					enhancer	enh				GTTGAAGCCCGGCCTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	direct	Highly Significant	NA				0.254276643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1295	chr1	28995280	28995302	28668768	28668790	72825	hg19					enhancer	enh				GGAGCATGCGCAGAGGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.14056206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1296	chr1	28995280	28995301	28668768	28668789	72826	hg19					enhancer	enh				GAGCATGCGCAGAGGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.704242876									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1297	chr1	28995289	28995311	28668777	28668799	72827	hg19					enhancer	enh				GCAGGCGACGGAGCATGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				0.133368173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1298	chr1	28995297	28995317	28668785	28668805	72828	hg19					enhancer	enh				GCTCCGTCGCCTGCCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	direct	Highly Significant	NA				0.450530701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-3432	chr1	28995333	28995354	28668821	28668842	72829	hg19	N/A	N/A	N/A	Enhatls3804	enhancer	enh				GCCCGCCCGACGGAGACGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				0.027468894	GMEB1	chr1	28668777	28719353	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3431
enhrx-3432	chr1	28995337	28995358	28668825	28668846	72830	hg19	N/A	N/A	N/A	Enhatls3804	enhancer	enh				GCCCGACGGAGACGGTGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.333419769	GMEB1	chr1	28668777	28719353	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3431
enhrx-3432	chr1	28995337	28995357	28668825	28668845	72831	hg19	N/A	N/A	N/A	Enhatls3804	enhancer	enh				GCCCGACGGAGACGGTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMEB1	indirect	Non Significant	NA				-0.691671421	GMEB1	chr1	28668777	28719353	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3431
enhrx-lit1299	chr1	29448042	29448062	29121530	29121550	72832	hg19					enhancer	enh				GATGAGCGAGCTGCGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.134692662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1300	chr1	29448051	29448072	29121539	29121560	72833	hg19					enhancer	enh				GCTCGCTCATCTGGGGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	direct	Highly Significant	NA				0.226608746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1301	chr1	29448102	29448123	29121590	29121611	72834	hg19					enhancer	enh				GCTACTGGCCGCACCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				0.113130963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1302	chr1	29448108	29448128	29121596	29121616	72835	hg19					enhancer	enh				GGCCGGCTACTGGCCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				0.117605015									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1303	chr1	29448118	29448139	29121606	29121627	72836	hg19					enhancer	enh				GGCATTGCAGTGGCCGGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.750851792									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1304	chr1	29448118	29448138	29121606	29121626	72837	hg19					enhancer	enh				GCATTGCAGTGGCCGGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.271160741									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1305	chr1	29448129	29448149	29121617	29121637	72838	hg19					enhancer	enh				GGTGGGTATGGGCATTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				0.135563674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1306	chr1	29448141	29448161	29121629	29121649	72839	hg19					enhancer	enh				GCTCGTGGTACTGGTGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.028005085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1307	chr1	29448141	29448163	29121629	29121651	72840	hg19					enhancer	enh				GCGCTCGTGGTACTGGTGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				0.026521487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1308	chr1	29448183	29448203	29121671	29121691	72841	hg19					enhancer	enh				GCGGCTGCGCTCGCCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.055948195									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1309	chr1	29448186	29448206	29121674	29121694	72842	hg19					enhancer	enh				GCTGCGGCTGCGCTCGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.425952062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1310	chr1	29448207	29448228	29121695	29121716	72843	hg19					enhancer	enh				GCGCCCGCACCCGCAGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.664773168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1311	chr1	29448213	29448234	29121701	29121722	72844	hg19					enhancer	enh				GCACCCGCAGAGGCTCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				0.101552795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1312	chr1	29448213	29448233	29121701	29121721	72845	hg19					enhancer	enh				GCCCGAGCCTCTGCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.192006932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1313	chr1	29448219	29448240	29121707	29121728	72846	hg19					enhancer	enh				GCTCCCCGCCCGAGCCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	direct	Highly Significant	NA				0.697395296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1314	chr1	29448264	29448284	29121752	29121772	72847	hg19					enhancer	enh				GGCGGCCCAAGCGAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.571968275									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1315	chr1	29448309	29448329	29121797	29121817	72848	hg19					enhancer	enh				GAGCCCCGAAGAATGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.133931089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1316	chr1	29448332	29448352	29121820	29121840	72849	hg19					enhancer	enh				GCCGTCATCTCGCCGTCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM200B	indirect	Non Significant	NA				-0.060671248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1317	chr1	31885863	31885883	31413016	31413036	72850	hg19					enhancer	enh				GTCAGGTTGCGCCGCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-1.49921908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1318	chr1	31885868	31885889	31413021	31413042	72851	hg19					enhancer	enh				GTTGCGCCGCTCGCGTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.051133941									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1319	chr1	31885877	31885897	31413030	31413050	72852	hg19					enhancer	enh				GATTCCCGCGGCCACGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	direct	Highly Significant	NA				0.201272634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1320	chr1	31885882	31885903	31413035	31413056	72853	hg19					enhancer	enh				GTGGCCGCGGGAATCCCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-0.376279814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1321	chr1	31885965	31885986	31413118	31413139	72854	hg19					enhancer	enh				GCGCCGCCGGAAAGCGTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-0.194731953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1322	chr1	31885971	31885993	31413124	31413146	72855	hg19					enhancer	enh				GAAGCCGCTCGACGCTTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	direct	Highly Significant	NA				0.351631458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1323	chr1	31885980	31886000	31413133	31413153	72856	hg19					enhancer	enh				GTCGAGCGGCTTCGGTAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	direct	Highly Significant	NA				0.395674611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1324	chr1	31886030	31886051	31413183	31413204	72857	hg19					enhancer	enh				GGAGGGGCCAGGCCCGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-0.260917075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1325	chr1	31886031	31886051	31413184	31413204	72858	hg19					enhancer	enh				GAGGGGCCAGGCCCGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-0.760688339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1326	chr1	31886040	31886060	31413193	31413213	72859	hg19					enhancer	enh				GGCCCGGCACCCGGATCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-1.612953174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1327	chr1	31886046	31886066	31413199	31413219	72860	hg19					enhancer	enh				GGACCTCGGGATCCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	direct	Highly Significant	NA				0.235915873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1328	chr1	31886046	31886068	31413199	31413221	72861	hg19					enhancer	enh				GCGGACCTCGGGATCCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.046274187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1329	chr1	31886053	31886073	31413206	31413226	72862	hg19					enhancer	enh				GGGGCGCGGACCTCGGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-1.153825548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1330	chr1	31886086	31886106	31413239	31413259	72863	hg19					enhancer	enh				GGCTCCCGGCTTCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				-0.628139295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1331	chr1	31886086	31886108	31413239	31413261	72864	hg19					enhancer	enh				GCGGCTCCCGGCTTCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.033898283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1332	chr1	31886093	31886115	31413246	31413268	72865	hg19					enhancer	enh				GAAGCCGGGAGCCGCCGCCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.024417452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1333	chr1	31886093	31886114	31413246	31413267	72866	hg19					enhancer	enh				GAAGCCGGGAGCCGCCGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.112684089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1334	chr1	31886126	31886148	31413279	31413301	72867	hg19					enhancer	enh				GCTGAGCAGGGAGCAGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	indirect	Non Significant	NA				0.000927574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1335	chr1	31886141	31886163	31413294	31413316	72868	hg19					enhancer	enh				GTCGGGACTCACGCAGCTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SERINC2	direct	Highly Significant	NA				0.387247393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1336	chr1	32671124	32671145	32205523	32205544	72869	hg19					enhancer	enh				GACGCAGGTACGCCTGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	direct	Highly Significant	NA				0.335319397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1337	chr1	32671228	32671250	32205627	32205649	72870	hg19					enhancer	enh				GCCGACCAATGACGTACTTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	direct	Highly Significant	NA				0.355446171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1338	chr1	32671238	32671258	32205637	32205657	72871	hg19					enhancer	enh				GACGTACTTCGCAGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				0.025507292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1339	chr1	32671241	32671261	32205640	32205660	72872	hg19					enhancer	enh				GTACTTCGCAGGCGCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				0.015462991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1340	chr1	32671262	32671283	32205661	32205682	72873	hg19					enhancer	enh				GGGCCTGGCAGTTGGCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.030638069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1341	chr1	32671263	32671283	32205662	32205682	72874	hg19					enhancer	enh				GGCCTGGCAGTTGGCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.188999377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1342	chr1	32671268	32671289	32205667	32205688	72875	hg19					enhancer	enh				GCTCCATGGGCGCCAACTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.206971333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1343	chr1	32671268	32671290	32205667	32205689	72876	hg19					enhancer	enh				GGCTCCATGGGCGCCAACTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.203875973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1344	chr1	32671276	32671298	32205675	32205697	72877	hg19					enhancer	enh				GCGCCCATGGAGCCAGAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.507111956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1345	chr1	32671278	32671298	32205677	32205697	72878	hg19					enhancer	enh				GCCCATGGAGCCAGAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.923457072									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1346	chr1	32671282	32671304	32205681	32205703	72879	hg19					enhancer	enh				GAACCAGCAGCTCTGGCTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.263406435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1347	chr1	32671285	32671307	32205684	32205706	72880	hg19					enhancer	enh				GAGCCAGAGCTGCTGGTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.231445772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1348	chr1	32671287	32671307	32205686	32205706	72881	hg19					enhancer	enh				GCCAGAGCTGCTGGTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.14540488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1349	chr1	32671308	32671330	32205707	32205729	72882	hg19					enhancer	enh				GGTGTCTGCATTGCAGGTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.033922533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1350	chr1	32671309	32671330	32205708	32205729	72883	hg19					enhancer	enh				GTGTCTGCATTGCAGGTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				0.101851415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1351	chr1	32671365	32671387	32205764	32205786	72884	hg19					enhancer	enh				GGAAATCATGGGGTCTCGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.714215334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1352	chr1	32671366	32671387	32205765	32205786	72885	hg19					enhancer	enh				GAAATCATGGGGTCTCGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.233214908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1353	chr1	32671397	32671417	32205796	32205816	72886	hg19					enhancer	enh				GAACGTGGTAGCATCTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IQCC	indirect	Non Significant	NA				-0.06465674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-4022	chr1	35497122	35497144	35031521	35031543	72887	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCACTCGCCACAAAATATCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.266893186	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497161	35497181	35031560	35031580	72888	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GGAAAGCGTGCGGTTCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.440141116	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497171	35497191	35031570	35031590	72889	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GGAGAATTTCGGAAAGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				0.021040192	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497192	35497213	35031591	35031612	72890	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GAGTGGGAATTCTTGGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-1.659773194	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497210	35497231	35031609	35031630	72891	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GTTAGTCCTCAATGATGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.542143053	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497216	35497236	35031615	35031635	72892	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCCTCGTTAGTCCTCAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.154095807	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497239	35497260	35031638	35031659	72893	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GTGGTCTCCGACTGAGAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.829453208	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497249	35497270	35031648	35031669	72894	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GGCTAGTCCACCGCTCTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				0.023329752	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497249	35497269	35031648	35031668	72895	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCTAGTCCACCGCTCTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.522202833	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497271	35497292	35031670	35031691	72896	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GTGAATGTCAACGCGTCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.527537965	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497309	35497330	35031708	35031729	72897	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCCCCAGCCGCGTAGCCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.050579302	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497314	35497334	35031713	35031733	72898	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCCAGGTGGGCTACGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.287447001	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497315	35497336	35031714	35031735	72899	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GTGCCAGGTGGGCTACGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				0.033200688	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497346	35497367	35031745	35031766	72900	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GCAACGCCTCGTCACGTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.030778738	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-4022	chr1	35497355	35497375	35031754	35031774	72901	hg19	N/A	N/A	N/A	Enhatls4454	enhancer	enh				GGAGGCCACACCACGTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				0.131656766	ZMYM6	chr1	34986164	35031945	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4021
enhrx-lit1354	chr1	35497427	35497447	35031826	35031846	72902	hg19					enhancer	enh				GTGCTCCTCCGGTAGCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZMYM6	indirect	Non Significant	NA				-0.51590471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1355	chr1	36863397	36863417	36397796	36397816	72903	hg19					enhancer	enh				GGGTCGCCGCCGAAGCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.117329013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1356	chr1	36863402	36863424	36397801	36397823	72904	hg19					enhancer	enh				GCCGCCGAAGCTAGCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.330340957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1357	chr1	36863408	36863429	36397807	36397828	72905	hg19					enhancer	enh				GAAGCTAGCGGGCGCCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.880703757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1358	chr1	36863421	36863443	36397820	36397842	72906	hg19					enhancer	enh				GCCTGGACTGGCTGCCTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.028346725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1359	chr1	36863431	36863453	36397830	36397852	72907	hg19					enhancer	enh				GCTGCCTCCCGCCGGCTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.408770363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1360	chr1	36863438	36863458	36397837	36397857	72908	hg19					enhancer	enh				GTCCTGCTGCAGCCGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.493978417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1361	chr1	36863445	36863467	36397844	36397866	72909	hg19					enhancer	enh				GGTTTCTCCGTCCTGCTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				0.068384146									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1362	chr1	36863445	36863466	36397844	36397865	72910	hg19					enhancer	enh				GTTTCTCCGTCCTGCTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.44685485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1363	chr1	36863451	36863471	36397850	36397870	72911	hg19					enhancer	enh				GCAGGACGGAGAAACCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.410965724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1364	chr1	36863458	36863478	36397857	36397877	72912	hg19					enhancer	enh				GGAGAAACCATGCCGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-1.856448129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1365	chr1	36863459	36863479	36397858	36397878	72913	hg19					enhancer	enh				GAGAAACCATGCCGGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-3.457455897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1366	chr1	36863468	36863488	36397867	36397887	72914	hg19					enhancer	enh				GAGCGGCCCGGTCGCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.503998365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1367	chr1	36863473	36863493	36397872	36397892	72915	hg19					enhancer	enh				GGACAGAGCGGCCCGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-1.755572992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1368	chr1	36863473	36863495	36397872	36397894	72916	hg19					enhancer	enh				GAGGACAGAGCGGCCCGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-0.510585027									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1369	chr1	36863480	36863500	36397879	36397899	72917	hg19					enhancer	enh				GCCCGGAGGACAGAGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-1.915261401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1370	chr1	36863480	36863502	36397879	36397901	72918	hg19					enhancer	enh				GCGCCCGGAGGACAGAGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.087581536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1371	chr1	36863497	36863519	36397896	36397918	72919	hg19					enhancer	enh				GAGCACTGACGCACTCTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-1.360263397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1372	chr1	36863497	36863517	36397896	36397916	72920	hg19					enhancer	enh				GCACTGACGCACTCTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				-2.19660751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1373	chr1	36863515	36863536	36397914	36397935	72921	hg19					enhancer	enh				GCTCTGCAAGTCACCGCGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	direct	Highly Significant	NA				0.264330258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1374	chr1	36863531	36863552	36397930	36397951	72922	hg19					enhancer	enh				GATTGTAGTTTCTCCGTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LSM10	indirect	Non Significant	NA				0.151277367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-4390	chr1	38471019	38471039	38005347	38005367	72923	hg19	N/A	N/A	N/A	Enhatls4836	enhancer	enh				GGCGCTCACCTCGAAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				0.387758027	FHL3	chr1	37996769	38005514	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4389
enhrx-lit1375	chr1	38471077	38471097	38005405	38005425	72924	hg19					enhancer	enh				GAACCGGGCGCCGCGTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.854984313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1376	chr1	38471090	38471110	38005418	38005438	72925	hg19					enhancer	enh				GTAGGAGCCGCCGAGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.412603502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1377	chr1	38471096	38471118	38005424	38005446	72926	hg19					enhancer	enh				GCCCGCAGGTAGGAGCCGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.048919553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1378	chr1	38471108	38471128	38005436	38005456	72927	hg19					enhancer	enh				GCTTGGCCCGGCCCGCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.180594076									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1379	chr1	38471131	38471151	38005459	38005479	72928	hg19					enhancer	enh				GGCCGAGCGAGCTGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.011327976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1380	chr1	38471136	38471158	38005464	38005486	72929	hg19					enhancer	enh				GCAGCCTCGCCGGCAGCTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				0.296192127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1381	chr1	38471148	38471169	38005476	38005497	72930	hg19					enhancer	enh				GTCTGCAGTCGGCAGCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.102300629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1382	chr1	38471148	38471168	38005476	38005496	72931	hg19					enhancer	enh				GCGAGGCTGCCGACTGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.132374663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1383	chr1	38471156	38471177	38005484	38005505	72932	hg19					enhancer	enh				GCCGACTGCAGACGGACCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.082207202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1384	chr1	38471160	38471182	38005488	38005510	72933	hg19					enhancer	enh				GCCCACACGGTCCGTCTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				0.253057374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1385	chr1	38471166	38471186	38005494	38005514	72934	hg19					enhancer	enh				GACGGACCGTGTGGGCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.158250158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1386	chr1	38471175	38471197	38005503	38005525	72935	hg19					enhancer	enh				GCCGCGCTCCCACTCGCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				0.32307642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1387	chr1	38471190	38471212	38005518	38005540	72936	hg19					enhancer	enh				GCGCGGCCCCAACCCCTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.022841228									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1388	chr1	38471192	38471212	38005520	38005540	72937	hg19					enhancer	enh				GCGGCCCCAACCCCTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.979582263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1389	chr1	38471201	38471223	38005529	38005551	72938	hg19					enhancer	enh				GCTCACTTCCTCGGGGAGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				1.036940485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1390	chr1	38471205	38471225	38005533	38005553	72939	hg19					enhancer	enh				GCGCTCACTTCCTCGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				0.18909941									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1391	chr1	38471210	38471230	38005538	38005558	72940	hg19					enhancer	enh				GGCCCGCGCTCACTTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	indirect	Non Significant	NA				-0.174474552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1392	chr1	38471298	38471318	38005626	38005646	72941	hg19					enhancer	enh				GGGCCGACTGGCGGCCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FHL3	direct	Highly Significant	NA				0.414874336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1393	chr1	41327282	41327302	40861610	40861630	72942	hg19					enhancer	enh				GTTCGACTGCTTCTCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.215934798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1394	chr1	41327287	41327308	40861615	40861636	72943	hg19					enhancer	enh				GAGAAGCAGTCGAACTCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.233888251									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1395	chr1	41327321	41327341	40861649	40861669	72944	hg19					enhancer	enh				GCTCGGGCAGCTCGCGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.367262903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1396	chr1	41327352	41327374	40861680	40861702	72945	hg19					enhancer	enh				GACGTCGCTGGAGCTGGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.408902195									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1397	chr1	41327360	41327380	40861688	40861708	72946	hg19					enhancer	enh				GGCGCTGACGTCGCTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.586057542									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1398	chr1	41327366	41327388	40861694	40861716	72947	hg19					enhancer	enh				GACGAGGAGGCGCTGACGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.152410114									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1399	chr1	41327381	41327403	40861709	40861731	72948	hg19					enhancer	enh				GACGCCGAACTCATCGACGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				0.115959992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1400	chr1	41327384	41327404	40861712	40861732	72949	hg19					enhancer	enh				GGACGCCGAACTCATCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.127933733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1401	chr1	41327391	41327413	40861719	40861741	72950	hg19					enhancer	enh				GAGTTCGGCGTCCATGCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.654690216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1402	chr1	41327393	41327414	40861721	40861742	72951	hg19					enhancer	enh				GTTCGGCGTCCATGCCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.006051597									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1403	chr1	41327393	41327413	40861721	40861741	72952	hg19					enhancer	enh				GTTCGGCGTCCATGCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.202623254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1404	chr1	41327440	41327461	40861768	40861789	72953	hg19					enhancer	enh				GCGGCGCTTGGCGCCGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.211769149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1405	chr1	41327440	41327460	40861768	40861788	72954	hg19					enhancer	enh				GCGGCGCTTGGCGCCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	direct	Highly Significant	NA				0.210352085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1406	chr1	41327445	41327467	40861773	40861795	72955	hg19					enhancer	enh				GCTTGGCGCCGGCTGCGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.031868794									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1407	chr1	41327445	41327466	40861773	40861794	72956	hg19					enhancer	enh				GCTTGGCGCCGGCTGCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				0.109472569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1408	chr1	41327470	41327490	40861798	40861818	72957	hg19					enhancer	enh				GGGCCTCCCGGAGCGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				-0.273548168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1409	chr1	41327594	41327614	40861922	40861942	72958	hg19					enhancer	enh				GCCCGAAGGCCCCGTACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CITED4	indirect	Non Significant	NA				0.067836129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1410	chr1	41481648	41481668	41015976	41015996	72959	hg19					enhancer	enh				GGACAGGGACTCCTTCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.467844377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1411	chr1	41481683	41481704	41016011	41016032	72960	hg19					enhancer	enh				GCCAACCAGTAAAGCCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.195942315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1412	chr1	41481697	41481717	41016025	41016045	72961	hg19					enhancer	enh				GGTTGGCCTTACACTCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.296483104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1413	chr1	41481728	41481748	41016056	41016076	72962	hg19					enhancer	enh				GCACTCTCCACCTGAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.085089319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1414	chr1	41481759	41481781	41016087	41016109	72963	hg19					enhancer	enh				GCCTGCTCCCCAGGGCCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.193199586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1415	chr1	41481771	41481791	41016099	41016119	72964	hg19					enhancer	enh				GCTGTGTCCTGTGAGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.313399474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1416	chr1	41481771	41481791	41016099	41016119	72965	hg19					enhancer	enh				GGGCCCTCACAGGACACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.982204267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1417	chr1	41481777	41481797	41016105	41016125	72966	hg19					enhancer	enh				GCACCTGCTGTGTCCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.109422656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1418	chr1	41481848	41481868	41016176	41016196	72967	hg19					enhancer	enh				GAAGATGAAGGCGCTGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.75735411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1419	chr1	41481848	41481870	41016176	41016198	72968	hg19					enhancer	enh				GAGAAGATGAAGGCGCTGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.602128688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1420	chr1	41481860	41481882	41016188	41016210	72969	hg19					enhancer	enh				GGCAAGCTGGAAGAGAAGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.683647354									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1421	chr1	41481860	41481881	41016188	41016209	72970	hg19					enhancer	enh				GCAAGCTGGAAGAGAAGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.309276002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1422	chr1	41481939	41481959	41016267	41016287	72971	hg19					enhancer	enh				GGACGGACAGGCCCGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.069473095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1423	chr1	41481945	41481965	41016273	41016293	72972	hg19					enhancer	enh				GGGCCTGTCCGTCCTCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.199738212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1424	chr1	41481951	41481971	41016279	41016299	72973	hg19					enhancer	enh				GCCCCAGGTGGAGGACGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.577375969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1425	chr1	41482001	41482023	41016329	41016351	72974	hg19					enhancer	enh				GCCTGAGAGCTTTCTCAGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.282974817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1426	chr1	41487505	41487526	41021833	41021854	72975	hg19					enhancer	enh				GCTGGGTGCGGGAAATCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.056291868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1427	chr1	41487554	41487574	41021882	41021902	72976	hg19					enhancer	enh				GGTCTGCTTCCAGTGTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.142084533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1428	chr1	41487588	41487610	41021916	41021938	72977	hg19					enhancer	enh				GTCCCACAGCCAAGCTGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.077310698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1429	chr1	41487620	41487642	41021948	41021970	72978	hg19					enhancer	enh				GCCTGAAGAGACATCACTAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.052425178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1430	chr1	41487621	41487643	41021949	41021971	72979	hg19					enhancer	enh				GGCCTGAAGAGACATCACTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-1.24043999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1431	chr1	41487621	41487642	41021949	41021970	72980	hg19					enhancer	enh				GCCTGAAGAGACATCACTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.492324878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1432	chr1	41487645	41487666	41021973	41021994	72981	hg19					enhancer	enh				GAGGTGACCTGCATGGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.010545567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1433	chr1	41487646	41487666	41021974	41021994	72982	hg19					enhancer	enh				GAGGTGACCTGCATGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.407030465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1434	chr1	41487652	41487674	41021980	41022002	72983	hg19					enhancer	enh				GGTGGCAAGAGGTGACCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.33021752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1435	chr1	41487652	41487673	41021980	41022001	72984	hg19					enhancer	enh				GTGGCAAGAGGTGACCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.177572011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1436	chr1	41487653	41487673	41021981	41022001	72985	hg19					enhancer	enh				GTGGCAAGAGGTGACCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.500597952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1437	chr1	41487665	41487685	41021993	41022013	72986	hg19					enhancer	enh				GCGCTGAAAGAGGTGGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.433357391									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1438	chr1	41487672	41487692	41022000	41022020	72987	hg19					enhancer	enh				GGCAGCAGCGCTGAAAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.478643772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1439	chr1	41487703	41487725	41022031	41022053	72988	hg19					enhancer	enh				GGTGACTGACTAAAGAGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-2.953237229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1440	chr1	41487703	41487724	41022031	41022052	72989	hg19					enhancer	enh				GTGACTGACTAAAGAGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.827994505									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1441	chr1	41487710	41487730	41022038	41022058	72990	hg19					enhancer	enh				GGATTGGTGACTGACTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				-0.213162023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1442	chr1	41487710	41487731	41022038	41022059	72991	hg19					enhancer	enh				GGGATTGGTGACTGACTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				1.267017411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1443	chr1	41487726	41487747	41022054	41022075	72992	hg19					enhancer	enh				GTACTCAGTAGAGCCTGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	direct	Highly Significant	NA				0.8008654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1444	chr1	41487731	41487751	41022059	41022079	72993	hg19					enhancer	enh				GTCAGTACTCAGTAGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLFNL1	indirect	Non Significant	NA				0.1371463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1445	chr1	43855360	43855380	43389689	43389709	72994	hg19					enhancer	enh				GACCGAGAGTGGGCTGGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				0.134203899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1446	chr1	43855366	43855387	43389695	43389716	72995	hg19					enhancer	enh				GTACAGGGACCGAGAGTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-1.154559649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1447	chr1	43855383	43855403	43389712	43389732	72996	hg19					enhancer	enh				GGCTGGCAAGCTTCGGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-2.148834185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1448	chr1	43855400	43855420	43389729	43389749	72997	hg19					enhancer	enh				GCGTTGGGCGTACTAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-1.157078614									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1449	chr1	43855404	43855425	43389733	43389754	72998	hg19					enhancer	enh				GAGTTGCGTTGGGCGTACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-2.358508663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1450	chr1	43855416	43855438	43389745	43389767	72999	hg19					enhancer	enh				GCAATGCAGGTGAGAGTTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-1.988093498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1451	chr1	43855418	43855440	43389747	43389769	73000	hg19					enhancer	enh				GCAACTCTCACCTGCATTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-1.23817733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1452	chr1	43855431	43855453	43389760	43389782	73001	hg19					enhancer	enh				GCCGCCTCGGCCGCCGCAATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-0.27966846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1453	chr1	43855446	43855467	43389775	43389796	73002	hg19					enhancer	enh				GTGAAATCGTGGCAGCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.286462598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1454	chr1	43855458	43855479	43389787	43389808	73003	hg19					enhancer	enh				GGAAAACCGGAAGTGAAATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				0.199581785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1455	chr1	43855458	43855478	43389787	43389807	73004	hg19					enhancer	enh				GAAAACCGGAAGTGAAATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.212918748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1456	chr1	43855472	43855492	43389801	43389821	73005	hg19					enhancer	enh				GCGTTTGCTGACTGGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				0.025566063									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1457	chr1	43855472	43855493	43389801	43389822	73006	hg19					enhancer	enh				GGCGTTTGCTGACTGGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				0.024974504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1458	chr1	43855480	43855500	43389809	43389829	73007	hg19					enhancer	enh				GTCAGCAAACGCCTACGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	direct	Highly Significant	NA				0.433769188									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1459	chr1	43855546	43855568	43389875	43389897	73008	hg19					enhancer	enh				GCACCCAGCAGGAACCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.506689581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1460	chr1	43855563	43855583	43389892	43389912	73009	hg19					enhancer	enh				GGTGCCGAGGTAGCGAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-0.488315558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1461	chr1	43855570	43855590	43389899	43389919	73010	hg19					enhancer	enh				GACCCCTGACCTCGCTACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-0.068482697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1462	chr1	43855575	43855595	43389904	43389924	73011	hg19					enhancer	enh				GCGAGGTCAGGGGTCAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.174696766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1463	chr1	43855587	43855609	43389916	43389938	73012	hg19					enhancer	enh				GTCAAGAGTGGAACACCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-1.657195874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1464	chr1	43855592	43855614	43389921	43389943	73013	hg19					enhancer	enh				GAGTGGAACACCCTCACTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	direct	Highly Significant	NA				0.604138119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1465	chr1	43855594	43855615	43389923	43389944	73014	hg19					enhancer	enh				GTGGAACACCCTCACTGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-1.450856184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1466	chr1	43855594	43855614	43389923	43389943	73015	hg19					enhancer	enh				GTGGAACACCCTCACTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				0.196253264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1467	chr1	43855597	43855619	43389926	43389948	73016	hg19					enhancer	enh				GAACACCCTCACTGGCCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-1.029557718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1468	chr1	43855605	43855625	43389934	43389954	73017	hg19					enhancer	enh				GCGCCGGCCCGGGCCAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-0.506591307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1469	chr1	43855626	43855646	43389955	43389975	73018	hg19					enhancer	enh				GGAGGGCTGTGTGATGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				0.044033934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1470	chr1	43855634	43855655	43389963	43389984	73019	hg19					enhancer	enh				GTGTGATGGCCTCGGAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				0.173347082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1471	chr1	43855641	43855661	43389970	43389990	73020	hg19					enhancer	enh				GGCCTCGGAGCGCCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MED8	indirect	Non Significant	NA				-3.183078219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1472	chr1	43855642	43855664	43389971	43389993	73021	hg19					enhancer	enh				GCCTCGGAGCGCCCGGAGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-1.895684094									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1473	chr1	43855657	43855679	43389986	43390008	73022	hg19					enhancer	enh				GCCCGCCCCTCACCTCCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.417713946									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1474	chr1	43855686	43855708	43390015	43390037	73023	hg19					enhancer	enh				GCACTGGGCCCCGAGATCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-0.76480733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1475	chr1	43855686	43855707	43390015	43390036	73024	hg19					enhancer	enh				GCACTGGGCCCCGAGATCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	direct	Highly Significant	NA				0.491825006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1476	chr1	43855720	43855741	43390049	43390070	73025	hg19					enhancer	enh				GCCAACGCCACGCCTGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				0.114948693									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1477	chr1	43855733	43855753	43390062	43390082	73026	hg19					enhancer	enh				GCGTTGGCCTCCTCTAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				-1.097814367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1478	chr1	43855758	43855778	43390087	43390107	73027	hg19					enhancer	enh				GTGGCCGGGCTGCGTAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SZT2	indirect	Non Significant	NA				0.055514911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1479	chr1	44678938	44678958	44213266	44213286	73028	hg19					enhancer	enh				GACGCAACGGAGCATCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	direct	Highly Significant	NA				0.222070375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1480	chr1	44679064	44679085	44213392	44213413	73029	hg19					enhancer	enh				GTTGTAGGAAACGAAGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.497461414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1481	chr1	44679089	44679110	44213417	44213438	73030	hg19					enhancer	enh				GCCGACAGAAACACTTCCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.133761101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1482	chr1	44679111	44679131	44213439	44213459	73031	hg19					enhancer	enh				GCGTTCCGAATGAGCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	direct	Highly Significant	NA				0.273232577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1483	chr1	44679112	44679132	44213440	44213460	73032	hg19					enhancer	enh				GGCGGTGCTCATTCGGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.574453874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1484	chr1	44679124	44679146	44213452	44213474	73033	hg19					enhancer	enh				GCACCGCCGGAAGTTTCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.199972931									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1485	chr1	44679130	44679150	44213458	44213478	73034	hg19					enhancer	enh				GCCGCGGCAGAAACTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.154531509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1486	chr1	44679136	44679156	44213464	44213484	73035	hg19					enhancer	enh				GTTTCTGCCGCGGCTTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.170796953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1487	chr1	44679142	44679162	44213470	44213490	73036	hg19					enhancer	enh				GCCGCGGCTTTGCGGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-2.0945208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1488	chr1	44679176	44679197	44213504	44213525	73037	hg19					enhancer	enh				GGGGCTGCAGCTGCCGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.125811802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1489	chr1	44679177	44679197	44213505	44213525	73038	hg19					enhancer	enh				GGGCTGCAGCTGCCGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.278892073									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1490	chr1	44679182	44679202	44213510	44213530	73039	hg19					enhancer	enh				GCAGCTGCCGGACCCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-1.642293953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1491	chr1	44679191	44679213	44213519	44213541	73040	hg19					enhancer	enh				GGACCCAGGTGCGGAAGTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.157600209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1492	chr1	44679192	44679213	44213520	44213541	73041	hg19					enhancer	enh				GACCCAGGTGCGGAAGTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.339553643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1493	chr1	44679197	44679218	44213525	44213546	73042	hg19					enhancer	enh				GGCCCTCGCACTTCCGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				0.100491023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1494	chr1	44679197	44679217	44213525	44213545	73043	hg19					enhancer	enh				GCCCTCGCACTTCCGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	direct	Highly Significant	NA				0.270381657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1495	chr1	44679209	44679230	44213537	44213558	73044	hg19					enhancer	enh				GCGAGGGCCCAGGTGGCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-1.800807359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1496	chr1	44679233	44679255	44213561	44213583	73045	hg19					enhancer	enh				GCCGTTAGGAACATCCAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.973232666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1497	chr1	44679236	44679256	44213564	44213584	73046	hg19					enhancer	enh				GTTAGGAACATCCAAGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMAP1	indirect	Non Significant	NA				-0.645622206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1498	chr1	45274046	45274066	44808374	44808394	73047	hg19					enhancer	enh				GGGCATTAAGCGCCATACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.206338003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1499	chr1	45274052	45274072	44808380	44808400	73048	hg19					enhancer	enh				GGCGCTTAATGCCCCTCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				0.107672632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1500	chr1	45274155	45274177	44808483	44808505	73049	hg19					enhancer	enh				GCTTCCCACCCCGTCGGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.082836628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1501	chr1	45274162	45274182	44808490	44808510	73050	hg19					enhancer	enh				GCCCAGGCAGCCGACGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	direct	Highly Significant	NA				0.245574845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1502	chr1	45274166	45274186	44808494	44808514	73051	hg19					enhancer	enh				GTCTGCCCAGGCAGCCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.078740253									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1503	chr1	45274166	45274188	44808494	44808516	73052	hg19					enhancer	enh				GAGTCTGCCCAGGCAGCCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.898452321									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1504	chr1	45274174	45274195	44808502	44808523	73053	hg19					enhancer	enh				GCCTGGGCAGACTCCCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	direct	Highly Significant	NA				0.264660575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1505	chr1	45274174	45274194	44808502	44808522	73054	hg19					enhancer	enh				GCCTGGGCAGACTCCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	direct	Highly Significant	NA				0.337566335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1506	chr1	45274190	45274212	44808518	44808540	73055	hg19					enhancer	enh				GGCGGCGAAAGAGGCCCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				0.106552041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1507	chr1	45274190	45274211	44808518	44808539	73056	hg19					enhancer	enh				GCGGCGAAAGAGGCCCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				0.044675453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1508	chr1	45274195	45274215	44808523	44808543	73057	hg19					enhancer	enh				GGCGGCGGCGAAAGAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.371171689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1509	chr1	45274229	45274251	44808557	44808579	73058	hg19					enhancer	enh				GCCAGCTTCTTCCCAGGACCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.006909996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1510	chr1	45274233	45274255	44808561	44808583	73059	hg19					enhancer	enh				GCCTATGGTCCTGGGAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.965017239									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1511	chr1	45274244	45274264	44808572	44808592	73060	hg19					enhancer	enh				GCTGGAGTGGCCTATGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				0.044108055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1512	chr1	45274244	45274265	44808572	44808593	73061	hg19					enhancer	enh				GGCTGGAGTGGCCTATGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.135053325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1513	chr1	45274250	45274270	44808578	44808598	73062	hg19					enhancer	enh				GCTGAGGCTGGAGTGGCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	indirect	Non Significant	NA				-0.352028191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1514	chr1	45274289	45274311	44808617	44808639	73063	hg19					enhancer	enh				GCTCGGGGACAGGAACAGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BTBD19	direct	Highly Significant	NA				0.610224573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1515	chr1	46152634	46152654	45686962	45686982	73064	hg19					enhancer	enh				GACGCGCACTGGCCAAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.141927462									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1516	chr1	46152639	46152661	45686967	45686989	73065	hg19					enhancer	enh				GTTTCGGGACGCGCACTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.09337352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1517	chr1	46152645	46152665	45686973	45686993	73066	hg19					enhancer	enh				GGTAGTTTCGGGACGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.389603306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1518	chr1	46152645	46152667	45686973	45686995	73067	hg19					enhancer	enh				GAGGTAGTTTCGGGACGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				0.189807095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1519	chr1	46152651	46152671	45686979	45686999	73068	hg19					enhancer	enh				GTCCCGAAACTACCTCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.361235636									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1520	chr1	46152672	46152693	45687000	45687021	73069	hg19					enhancer	enh				GGACTTGCAAACCGGTTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.293305315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1521	chr1	46152673	46152693	45687001	45687021	73070	hg19					enhancer	enh				GACTTGCAAACCGGTTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.258769091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1522	chr1	46152721	46152742	45687049	45687070	73071	hg19					enhancer	enh				GAGAAGTAAGGAGCGGAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.565955612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1523	chr1	46152722	46152742	45687050	45687070	73072	hg19					enhancer	enh				GAGAAGTAAGGAGCGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.286911857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1524	chr1	46152729	46152750	45687057	45687078	73073	hg19					enhancer	enh				GCGCACACGAGAAGTAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				0.164310889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1525	chr1	46152753	46152774	45687081	45687102	73074	hg19					enhancer	enh				GTTGAGACTCCAGTCCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.495165521									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1526	chr1	46152753	46152773	45687081	45687101	73075	hg19					enhancer	enh				GTTGAGACTCCAGTCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.544149728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1527	chr1	46152765	46152786	45687093	45687114	73076	hg19					enhancer	enh				GCCGTGTGGCCCGCTGGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	direct	Highly Significant	NA				0.795386662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1528	chr1	46152771	46152791	45687099	45687119	73077	hg19					enhancer	enh				GCCAGGCCGTGTGGCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.032573066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1529	chr1	46152809	46152830	45687137	45687158	73078	hg19					enhancer	enh				GCGTCGGCCGCGCTACCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.387898323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1530	chr1	46152875	46152896	45687203	45687224	73079	hg19					enhancer	enh				GCCGGAATCCCGCCCTTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.069302697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1531	chr1	46152904	46152926	45687232	45687254	73080	hg19					enhancer	enh				GAAACGGCACTGTCGCAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPBP1L1	indirect	Non Significant	NA				-0.987573806									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1532	chr1	46153691	46153712	45688019	45688040	73081	hg19					enhancer	enh				GGTCCTTGAAGTTCTATTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	direct	Highly Significant	NA				0.30112938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1533	chr1	46153767	46153787	45688095	45688115	73082	hg19					enhancer	enh				GCCTAGGAACCAATTAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.132262495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1534	chr1	46153783	46153803	45688111	45688131	73083	hg19					enhancer	enh				GCGCAGGTCAAGTCCCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.449523282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1535	chr1	46153825	46153845	45688153	45688173	73084	hg19					enhancer	enh				GAGAGGCCCCTACTTCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.161940568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1536	chr1	46153853	46153873	45688181	45688201	73085	hg19					enhancer	enh				GGAAAGGCACTTCCGGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	direct	Highly Significant	NA				0.414713203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1537	chr1	46153859	46153881	45688187	45688209	73086	hg19					enhancer	enh				GGAAGTGCCTTTCCAGTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.13481896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1538	chr1	46153860	46153881	45688188	45688209	73087	hg19					enhancer	enh				GAAGTGCCTTTCCAGTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.095262024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1539	chr1	46153860	46153882	45688188	45688210	73088	hg19					enhancer	enh				GAAGTGCCTTTCCAGTGGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.219777282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1540	chr1	46153874	46153895	45688202	45688223	73089	hg19					enhancer	enh				GCAACAACAGCCCAGGTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.122736818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1541	chr1	46153907	46153927	45688235	45688255	73090	hg19					enhancer	enh				GCCAGCGTTGCACGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	direct	Highly Significant	NA				0.459578405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1542	chr1	46153924	46153945	45688252	45688273	73091	hg19					enhancer	enh				GGCAAGTCTCAAAGTCGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	direct	Highly Significant	NA				0.534162649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1543	chr1	46153925	46153945	45688253	45688273	73092	hg19					enhancer	enh				GCAAGTCTCAAAGTCGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.004048925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1544	chr1	46153952	46153973	45688280	45688301	73093	hg19					enhancer	enh				GGTTGGGATGGGAGGCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.278820099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1545	chr1	46153953	46153973	45688281	45688301	73094	hg19					enhancer	enh				GTTGGGATGGGAGGCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.023875576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1546	chr1	46153975	46153997	45688303	45688325	73095	hg19					enhancer	enh				GTTGGTAGTAAATTTGCGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				0.103680593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1547	chr1	46153982	46154002	45688310	45688330	73096	hg19					enhancer	enh				GTAAATTTGCGACGTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.533491807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1548	chr1	46153995	46154016	45688323	45688344	73097	hg19					enhancer	enh				GTTGGGATGGGAGGGCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.015383866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1549	chr1	46154009	46154031	45688337	45688359	73098	hg19					enhancer	enh				GCACCAAGGGTTGGTAGTAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.16143966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1550	chr1	46154018	46154040	45688346	45688368	73099	hg19					enhancer	enh				GTTGGTAGTAAATTGGAGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.334407376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1551	chr1	46154033	46154054	45688361	45688382	73100	hg19					enhancer	enh				GAGACGCGGGCACTCTCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM69	indirect	Non Significant	NA				-0.162217379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1552	chr1	46769209	46769230	46303537	46303558	73101	hg19					enhancer	enh				GTTTCTTAGCAAAGCCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	direct	Highly Significant	NA				0.602353828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1553	chr1	46769226	46769246	46303554	46303574	73102	hg19					enhancer	enh				GCTGATGTTTGCACCCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	direct	Highly Significant	NA				0.277155525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1554	chr1	46769244	46769265	46303572	46303593	73103	hg19					enhancer	enh				GCTACCCCTAACCTCTGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.302350984									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1555	chr1	46769258	46769278	46303586	46303606	73104	hg19					enhancer	enh				GTACTACCAGCCGCAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.633514123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1556	chr1	46769307	46769327	46303635	46303655	73105	hg19					enhancer	enh				GAAGTGCGGCACACTCATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	direct	Highly Significant	NA				0.459541065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1557	chr1	46769317	46769339	46303645	46303667	73106	hg19					enhancer	enh				GCCGCACTTCCGGCCAGATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				0.014740032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1558	chr1	46769329	46769350	46303657	46303678	73107	hg19					enhancer	enh				GCGGAAATCCGGCGATCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	direct	Highly Significant	NA				0.245522271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1559	chr1	46769349	46769370	46303677	46303698	73108	hg19					enhancer	enh				GGACTTGTAAGGGTCACTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.077936478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1560	chr1	46769349	46769369	46303677	46303697	73109	hg19					enhancer	enh				GACTTGTAAGGGTCACTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.131994744									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1561	chr1	46769360	46769380	46303688	46303708	73110	hg19					enhancer	enh				GGATCAAGAAGGACTTGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.336066101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1562	chr1	46769399	46769421	46303727	46303749	73111	hg19					enhancer	enh				GATTCAACACGAGCAGCAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.229277597									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1563	chr1	46769480	46769500	46303808	46303828	73112	hg19					enhancer	enh				GATCCTGAGGAGGTAAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	direct	Highly Significant	NA				0.316765824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1564	chr1	46769486	46769508	46303814	46303836	73113	hg19					enhancer	enh				GATCGCCTTGCCTTACCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.003682526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1565	chr1	46769492	46769512	46303820	46303840	73114	hg19					enhancer	enh				GTAAGGCAAGGCGATCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UQCRH	indirect	Non Significant	NA				-0.09480396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1566	chr1	46977859	46977881	46512187	46512209	73115	hg19					enhancer	enh				GCACTACTCGTCCTTCGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-0.184905457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1567	chr1	46977859	46977880	46512187	46512208	73116	hg19					enhancer	enh				GCACTACTCGTCCTTCGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	direct	Highly Significant	NA				0.810618204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1568	chr1	46977889	46977909	46512217	46512237	73117	hg19					enhancer	enh				GGCCCCTGCTGCTGCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-0.332490851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1569	chr1	46977910	46977930	46512238	46512258	73118	hg19					enhancer	enh				GGCTGCTGCTGTGCCCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				0.106974371									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1570	chr1	46977911	46977931	46512239	46512259	73119	hg19					enhancer	enh				GCTGCTGCTGTGCCCTACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	direct	Highly Significant	NA				0.316112166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1571	chr1	46977920	46977942	46512248	46512270	73120	hg19					enhancer	enh				GTGCCCTACCTGGGCGTCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				0.061705925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1572	chr1	46977922	46977942	46512250	46512270	73121	hg19					enhancer	enh				GCCCTACCTGGGCGTCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				0.157946241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1573	chr1	46977926	46977946	46512254	46512274	73122	hg19					enhancer	enh				GCCATGTTGACGCCCAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	direct	Highly Significant	NA				0.292838738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1574	chr1	46977931	46977952	46512259	46512280	73123	hg19					enhancer	enh				GGGCGTCAACATGGCCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-2.624973522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1575	chr1	46977931	46977951	46512259	46512279	73124	hg19					enhancer	enh				GCGGGGCCATGTTGACGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-0.145403902									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1576	chr1	46977932	46977952	46512260	46512280	73125	hg19					enhancer	enh				GGCGTCAACATGGCCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-0.334168049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1577	chr1	46977948	46977968	46512276	46512296	73126	hg19					enhancer	enh				GCAGTGCAGTGAGCCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				0.02028048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1578	chr1	46977970	46977991	46512298	46512319	73127	hg19					enhancer	enh				GACAGGGACTGGTAGTAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				0.162140377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1579	chr1	46977982	46978003	46512310	46512331	73128	hg19					enhancer	enh				GCAGCGGCTGCTGACAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-1.686705728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1580	chr1	46977987	46978007	46512315	46512335	73129	hg19					enhancer	enh				GGCAGCAGCGGCTGCTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DMBX1	indirect	Non Significant	NA				-0.234297492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1581	chr1	47133842	47133863	46668170	46668191	73130	hg19					enhancer	enh				GCGCGTCTTCCCAGTGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.173103579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1582	chr1	47133867	47133887	46668195	46668215	73131	hg19					enhancer	enh				GCGCGGGTGACACGAGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.146194999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1583	chr1	47133913	47133933	46668241	46668261	73132	hg19					enhancer	enh				GCACAGGCCCCGGTAGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	direct	Highly Significant	NA				0.286663406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1584	chr1	47133924	47133944	46668252	46668272	73133	hg19					enhancer	enh				GCAGGTGGCCGGTCTCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.670946776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1585	chr1	47133930	47133952	46668258	46668280	73134	hg19					enhancer	enh				GACCGGCCACCTGCAGGACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.248661081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1586	chr1	47133971	47133993	46668299	46668321	73135	hg19					enhancer	enh				GCCGCCACCACCACAGCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.075729974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1587	chr1	47134017	47134039	46668345	46668367	73136	hg19					enhancer	enh				GCCGAGGCCGACGCGCCTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.005054718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1588	chr1	47134087	47134107	46668415	46668435	73137	hg19					enhancer	enh				GGAACCTCGGTGCCGGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.264158162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1589	chr1	47134094	47134114	46668422	46668442	73138	hg19					enhancer	enh				GGCGCGCGGAACCTCGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.147518575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1590	chr1	47134179	47134199	46668507	46668527	73139	hg19					enhancer	enh				GGCGAGAGCGCGCAGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.326345897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1591	chr1	47134204	47134225	46668532	46668553	73140	hg19					enhancer	enh				GAGGCGGGCCGTGGCATACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.062199033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1592	chr1	47184589	47184609	46718917	46718937	73141	hg19					enhancer	enh				GAGTTTGAGGTCTCCGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	direct	Highly Significant	NA				0.230499015									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1593	chr1	47184735	47184756	46719063	46719084	73142	hg19					enhancer	enh				GGCGGCCGCGAGCTCCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.070753129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1594	chr1	47184736	47184756	46719064	46719084	73143	hg19					enhancer	enh				GCGGCCGCGAGCTCCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.092215399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1595	chr1	47184763	47184783	46719091	46719111	73144	hg19					enhancer	enh				GTGATCTGGGGCTGGAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.236325807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1596	chr1	47184777	47184798	46719105	46719126	73145	hg19					enhancer	enh				GCTGCCAAAGGGGAAGTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.418404728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1597	chr1	47184777	47184797	46719105	46719125	73146	hg19					enhancer	enh				GATCACTTCCCCTTTGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.088247383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1598	chr1	47184789	47184811	46719117	46719139	73147	hg19					enhancer	enh				GGCGCAGGCGGCCGCTGCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	direct	Highly Significant	NA				0.48053681									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1599	chr1	47184789	47184810	46719117	46719138	73148	hg19					enhancer	enh				GCGCAGGCGGCCGCTGCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.138099199									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1600	chr1	47184803	47184825	46719131	46719153	73149	hg19					enhancer	enh				GCTTACTGGCAGGCGGCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.040827041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1601	chr1	47184806	47184826	46719134	46719154	73150	hg19					enhancer	enh				GGCTTACTGGCAGGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.048968585									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1602	chr1	47184815	47184836	46719143	46719164	73151	hg19					enhancer	enh				GCCAGTAAGCCGCACTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.231410797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1603	chr1	47184826	47184847	46719154	46719175	73152	hg19					enhancer	enh				GCACTCCCATTGGTCGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.081737718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1604	chr1	47184856	47184877	46719184	46719205	73153	hg19					enhancer	enh				GTCACGCCGGGGCGAAAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.472717863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1605	chr1	47184925	47184945	46719253	46719273	73154	hg19					enhancer	enh				GTCCCACCTGCCGATTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				-0.206601703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1606	chr1	47184934	47184954	46719262	46719282	73155	hg19					enhancer	enh				GCGGGGCCACCCTAATCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFCAB14	indirect	Non Significant	NA				0.09810879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1607	chr1	47606254	47606274	47140582	47140602	73156	hg19					enhancer	enh				GAGTGAGGGCTCATAGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	indirect	Non Significant	NA				-0.859949463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1608	chr1	47606441	47606463	47140769	47140791	73157	hg19					enhancer	enh				GTCGTGTTGGAACTGTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	direct	Highly Significant	NA				0.514552329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1609	chr1	47606443	47606464	47140771	47140792	73158	hg19					enhancer	enh				GTTGACAGTTCCAACACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	indirect	Non Significant	NA				0.023225271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1610	chr1	47606466	47606488	47140794	47140816	73159	hg19					enhancer	enh				GAGCTACAACGGATTCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	direct	Highly Significant	NA				0.289008884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1611	chr1	47606468	47606488	47140796	47140816	73160	hg19					enhancer	enh				GCTACAACGGATTCAGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	direct	Highly Significant	NA				0.542994587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1612	chr1	47606608	47606628	47140936	47140956	73161	hg19					enhancer	enh				GAGAAATTGCAGTTGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	indirect	Non Significant	NA				-0.131228655									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1613	chr1	47606615	47606635	47140943	47140963	73162	hg19					enhancer	enh				GAGGGAAGAGAAATTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP4A22	direct	Highly Significant	NA				0.719341123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-5451	chr1	47651399	47651419	47185727	47185747	73163	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GGCATCTAAGTTTCTCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	direct	Highly Significant	NA				0.38506718	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651402	47651423	47185730	47185751	73164	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GAATGGCATCTAAGTTTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	direct	Highly Significant	NA				0.849254996	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651433	47651454	47185761	47185782	73165	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GACAGCAGCGGACTCGAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.363336089	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651438	47651460	47185766	47185788	73166	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCACAGACAGCAGCGGACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.084154868	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651446	47651467	47185774	47185795	73167	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTTGGTCGTCACAGACAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				0.043614485	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651451	47651472	47185779	47185800	73168	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCTGTGACGACCAACTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				0.124063423	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651451	47651471	47185779	47185799	73169	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCTGTGACGACCAACTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	direct	Highly Significant	NA				0.275174049	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651465	47651485	47185793	47185813	73170	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GAGGTGGGCACCCTGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-1.202709076	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651471	47651491	47185799	47185819	73171	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCTAGGAGGTGGGCACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				0.162911545	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651472	47651494	47185800	47185822	73172	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GCTGTCTAGGAGGTGGGCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.491581503	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651480	47651502	47185808	47185830	73173	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCTGAGCGCTGTCTAGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.463167786	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651481	47651502	47185809	47185830	73174	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GTCTGAGCGCTGTCTAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	direct	Highly Significant	NA				0.628341645	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651484	47651504	47185812	47185832	73175	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GAGTCTGAGCGCTGTCTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.273966903	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651522	47651542	47185850	47185870	73176	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GGACTGTAGCGGTGGCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.271091459	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651612	47651632	47185940	47185960	73177	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GCTGCCGTGCATCTGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				-0.174659455	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651619	47651639	47185947	47185967	73178	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GCTGCCTCGTGGCAGATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				0.04369663	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651630	47651650	47185958	47185978	73179	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GAATGACTCTGGCTGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	indirect	Non Significant	NA				0.021620272	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-5451	chr1	47651657	47651677	47185985	47186005	73180	hg19	N/A	N/A	N/A	Enhatls5968	enhancer	enh				GCCGTGTCTCATCCCGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDZK1IP1	direct	Highly Significant	NA				0.238232953	PDZK1IP1	chr1	47183581	47191044	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5450
enhrx-lit1614	chr1	47697698	47697718	47232026	47232046	73181	hg19					enhancer	enh				GTTCCTTTCGATGGCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.066088702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1615	chr1	47697720	47697742	47232048	47232070	73182	hg19					enhancer	enh				GAGGTCTTCGCTCCCTTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.101083017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1616	chr1	47697769	47697789	47232097	47232117	73183	hg19					enhancer	enh				GAAATTGATGAAGAATTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				0.171894421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1617	chr1	47697778	47697800	47232106	47232128	73184	hg19					enhancer	enh				GAAGAATTCGGTGGGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	direct	Highly Significant	NA				0.527326943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1618	chr1	47697870	47697891	47232198	47232219	73185	hg19					enhancer	enh				GCTCAGGACCGGGCCTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				0.198378903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1619	chr1	47697874	47697896	47232202	47232224	73186	hg19					enhancer	enh				GAGGCCCGGTCCTGAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.248081764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1620	chr1	47697876	47697896	47232204	47232224	73187	hg19					enhancer	enh				GGCCCGGTCCTGAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.488387834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1621	chr1	47697881	47697901	47232209	47232229	73188	hg19					enhancer	enh				GGCCGCCGCCGCTCAGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.663754307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1622	chr1	47697882	47697902	47232210	47232230	73189	hg19					enhancer	enh				GGGCCGCCGCCGCTCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.424785759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1623	chr1	47697953	47697974	47232281	47232302	73190	hg19					enhancer	enh				GATTACAGCGCGTCGGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.354338639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1624	chr1	47697958	47697978	47232286	47232306	73191	hg19					enhancer	enh				GTGGGATTACAGCGCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.396577274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1625	chr1	47697982	47698002	47232310	47232330	73192	hg19					enhancer	enh				GTTCCAGGCCTCGTTAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.399585229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1626	chr1	47697988	47698008	47232316	47232336	73193	hg19					enhancer	enh				GGCCTCGTTAGCATGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.493077028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1627	chr1	47697993	47698014	47232321	47232342	73194	hg19					enhancer	enh				GCGCCTCGGCCCATGCTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				0.124371605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1628	chr1	47697998	47698018	47232326	47232346	73195	hg19					enhancer	enh				GCATGGGCCGAGGCGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.76412403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1629	chr1	47698020	47698041	47232348	47232369	73196	hg19					enhancer	enh				GCCGTGTGCGCCGCAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				0.07527512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1630	chr1	47698032	47698052	47232360	47232380	73197	hg19					enhancer	enh				GCAGAGATAAGGCACTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAL1	indirect	Non Significant	NA				-0.09826736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-5476	chr1	47779696	47779718	47314024	47314046	73198	hg19	N/A	N/A	N/A	Enhatls5993	enhancer	enh				GCTCCACTTACCGCAACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.363334731	STIL	chr1	47250138	47314892	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5475
enhrx-lit1631	chr1	47779702	47779724	47314030	47314052	73199	hg19					enhancer	enh				GCTCCGCGGAAGTTGCGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.85230263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1632	chr1	47779718	47779738	47314046	47314066	73200	hg19					enhancer	enh				GCAAACAGACCTCAGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.241761236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1633	chr1	47779728	47779749	47314056	47314077	73201	hg19					enhancer	enh				GTCTGTTTGCAGGGTAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.195088517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1634	chr1	47779741	47779763	47314069	47314091	73202	hg19					enhancer	enh				GTAGGAGCGGGAGCCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.537548839									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1635	chr1	47779757	47779778	47314085	47314106	73203	hg19					enhancer	enh				GGCGGTGGCGCTCCTTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.108563032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1636	chr1	47779757	47779777	47314085	47314105	73204	hg19					enhancer	enh				GCGGTGGCGCTCCTTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-1.161563644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1637	chr1	47779775	47779795	47314103	47314123	73205	hg19					enhancer	enh				GCCGACTCCGGCCCCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.36071781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1638	chr1	47779779	47779801	47314107	47314129	73206	hg19					enhancer	enh				GTCCCAGAGGCGGGGCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.318561484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1639	chr1	47779789	47779810	47314117	47314138	73207	hg19					enhancer	enh				GACCCCAACGTCCCAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.842804631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1640	chr1	47779790	47779811	47314118	47314139	73208	hg19					enhancer	enh				GCCTCTGGGACGTTGGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.600822881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1641	chr1	47779798	47779820	47314126	47314148	73209	hg19					enhancer	enh				GACGTTGGGGTCGCGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.242323422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1642	chr1	47779801	47779823	47314129	47314151	73210	hg19					enhancer	enh				GTTGGGGTCGCGGGAACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.355192808									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1643	chr1	47779855	47779876	47314183	47314204	73211	hg19					enhancer	enh				GACCAGTCAGCAGGCGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.257596538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1644	chr1	47779872	47779892	47314200	47314220	73212	hg19					enhancer	enh				GGTCAGAAACCTCGCCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.017186585									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1645	chr1	47779903	47779924	47314231	47314252	73213	hg19					enhancer	enh				GTGGTGCTAGAGAGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				-0.085455385									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1646	chr1	47779933	47779953	47314261	47314281	73214	hg19					enhancer	enh				GTCGGCACACCAATACGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.218562914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1647	chr1	47779950	47779970	47314278	47314298	73215	hg19					enhancer	enh				GACCAATCAGCGCCCCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	direct	Highly Significant	NA				0.342871797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1648	chr1	47779965	47779986	47314293	47314314	73216	hg19					enhancer	enh				GTCGAGCGCGGAACCAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				0.104582336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1649	chr1	47779978	47779998	47314306	47314326	73217	hg19					enhancer	enh				GACTTGGGATTGGTCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STIL	indirect	Non Significant	NA				0.028417434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1650	chr1	47799420	47799440	47333748	47333768	73218	hg19					enhancer	enh				GCGTCTCGGCGACACTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				0.013876482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1651	chr1	47799464	47799485	47333792	47333813	73219	hg19					enhancer	enh				GCGTCCGCGGCCCTGTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				0.145131277									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1652	chr1	47799566	47799588	47333894	47333916	73220	hg19					enhancer	enh				GCTGACAGCGGCCGGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.170651715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1653	chr1	47799571	47799591	47333899	47333919	73221	hg19					enhancer	enh				GGAGCTGACAGCGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.688578495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1654	chr1	47799571	47799592	47333899	47333920	73222	hg19					enhancer	enh				GGGAGCTGACAGCGGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	direct	Highly Significant	NA				0.295713987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1655	chr1	47799580	47799601	47333908	47333929	73223	hg19					enhancer	enh				GGACGCTGAGGGAGCTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.636079659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1656	chr1	47799580	47799600	47333908	47333928	73224	hg19					enhancer	enh				GACGCTGAGGGAGCTGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-1.994654007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1657	chr1	47799586	47799606	47333914	47333934	73225	hg19					enhancer	enh				GCTCCCTCAGCGTCCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	direct	Highly Significant	NA				0.346657624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1658	chr1	47799592	47799612	47333920	47333940	73226	hg19					enhancer	enh				GCGCCTCGGCCGGACGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-1.544145281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1659	chr1	47799606	47799626	47333934	47333954	73227	hg19					enhancer	enh				GCTCAGCATACACCGCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.361088485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1660	chr1	47799606	47799627	47333934	47333955	73228	hg19					enhancer	enh				GGCTCAGCATACACCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.284022339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1661	chr1	47799615	47799637	47333943	47333965	73229	hg19					enhancer	enh				GTATGCTGAGCCGCTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.484183229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1662	chr1	47799628	47799648	47333956	47333976	73230	hg19					enhancer	enh				GGAGCAGCCCGCTGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				0.12339294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1663	chr1	47799628	47799650	47333956	47333978	73231	hg19					enhancer	enh				GTGGAGCAGCCCGCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	direct	Highly Significant	NA				0.281808639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1664	chr1	47799633	47799654	47333961	47333982	73232	hg19					enhancer	enh				GCAGCGGGCTGCTCCACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.16707208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1665	chr1	47799634	47799654	47333962	47333982	73233	hg19					enhancer	enh				GGACGTGGAGCAGCCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-0.126827267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1666	chr1	47799655	47799675	47333983	47334003	73234	hg19					enhancer	enh				GCAGCAGGAAGCTAAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				-1.740931599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1667	chr1	47799663	47799683	47333991	47334011	73235	hg19					enhancer	enh				GCTTCCTGCTGCAGACCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK1	indirect	Non Significant	NA				0.080343463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1668	chr1	52499275	52499295	52033603	52033623	73236	hg19					enhancer	enh				GCAGAATCGCCGTACACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.060296733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1669	chr1	52499312	52499332	52033640	52033660	73237	hg19					enhancer	enh				GGTGGACGACGCAGCTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.223325392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1670	chr1	52499322	52499344	52033650	52033672	73238	hg19					enhancer	enh				GTCGTCCACCACGTACACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-1.286002322									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1671	chr1	52499350	52499371	52033678	52033699	73239	hg19					enhancer	enh				GCGCGTGGCGCTGGCTGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	direct	Highly Significant	NA				0.259072625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1672	chr1	52499351	52499371	52033679	52033699	73240	hg19					enhancer	enh				GCGCGTGGCGCTGGCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	direct	Highly Significant	NA				0.679375606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1673	chr1	52499360	52499382	52033688	52033710	73241	hg19					enhancer	enh				GCTGAAGAGTTGCGCGTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				0.081484942									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1674	chr1	52499366	52499387	52033694	52033715	73242	hg19					enhancer	enh				GGCGTGCTGAAGAGTTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	direct	Highly Significant	NA				0.427463471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1675	chr1	52499366	52499386	52033694	52033714	73243	hg19					enhancer	enh				GCGTGCTGAAGAGTTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-1.005082584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1676	chr1	52499388	52499410	52033716	52033738	73244	hg19					enhancer	enh				GCTGCCGTACAGCGGCAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.237277067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1677	chr1	52499405	52499427	52033733	52033755	73245	hg19					enhancer	enh				GCAGCCCGCAAAACACCACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.928889221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1678	chr1	52499436	52499456	52033764	52033784	73246	hg19					enhancer	enh				GCCAATGGTCGCTCCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-1.244641346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1679	chr1	52499451	52499473	52033779	52033801	73247	hg19					enhancer	enh				GTTGGCGCAGCGCGGTTGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-1.437325963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1680	chr1	52499471	52499491	52033799	52033819	73248	hg19					enhancer	enh				GACGCGTACAACCCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.35889219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1681	chr1	52499471	52499493	52033799	52033821	73249	hg19					enhancer	enh				GAGACGCGTACAACCCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.256016215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1682	chr1	52499482	52499503	52033810	52033831	73250	hg19					enhancer	enh				GTACGCGTCTCCGACGTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				0.026206588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1683	chr1	52499495	52499516	52033823	52033844	73251	hg19					enhancer	enh				GTTTGCACTTCCGGCTTACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				0.036237934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1684	chr1	52499526	52499548	52033854	52033876	73252	hg19					enhancer	enh				GTCTGTAAAAGTCAAGGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-1.502399849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1685	chr1	52499572	52499592	52033900	52033920	73253	hg19					enhancer	enh				GTTCTACGCCAGCTAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	direct	Highly Significant	NA				0.224777534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1686	chr1	52499583	52499605	52033911	52033933	73254	hg19					enhancer	enh				GAAAGCTGAACCTGGGCCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KTI12	indirect	Non Significant	NA				-0.374638996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1687	chr1	54665524	54665545	54199851	54199872	73255	hg19					enhancer	enh				GAGGGACACTGGGCCTCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.455777361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1688	chr1	54665562	54665582	54199889	54199909	73256	hg19					enhancer	enh				GCTTATGAGCAGTTGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				0.172717375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1689	chr1	54665569	54665590	54199896	54199917	73257	hg19					enhancer	enh				GGTTGACTGCTTATGAGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.705618556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1690	chr1	54665569	54665589	54199896	54199916	73258	hg19					enhancer	enh				GTTGACTGCTTATGAGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.37567699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1691	chr1	54665580	54665602	54199907	54199929	73259	hg19					enhancer	enh				GCAGTCAACCTTGTCTAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.320963613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1692	chr1	54665616	54665636	54199943	54199963	73260	hg19					enhancer	enh				GGTGGGTGGAGAATCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.349498674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1693	chr1	54665616	54665638	54199943	54199965	73261	hg19					enhancer	enh				GTGGTGGGTGGAGAATCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	direct	Highly Significant	NA				0.215171881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1694	chr1	54665650	54665670	54199977	54199997	73262	hg19					enhancer	enh				GAGGTGAAGCGCAGGCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.465544363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1695	chr1	54665654	54665675	54199981	54200002	73263	hg19					enhancer	enh				GCCTGCGCTTCACCTCACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.025532714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1696	chr1	54665669	54665691	54199996	54200018	73264	hg19					enhancer	enh				GAACCTGGAAAATCCTCACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.260370381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1697	chr1	54665686	54665707	54200013	54200034	73265	hg19					enhancer	enh				GGTTCCTCCCAGTCTCTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.343160647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1698	chr1	54665687	54665707	54200014	54200034	73266	hg19					enhancer	enh				GTTCCTCCCAGTCTCTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.434633527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1699	chr1	54665696	54665718	54200023	54200045	73267	hg19					enhancer	enh				GCTCCCCGCCTACCCAGAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYB5RL	indirect	Non Significant	NA				-0.470485643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-6031	chr1	55230087	55230109	54764414	54764436	73268	hg19	N/A	N/A	N/A	Enhatls6574	enhancer	enh				GCCCGCGCCCGTCCCTCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-0.150919675	PARS2	chr1	54756897	54764523	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6030
enhrx-6031	chr1	55230097	55230117	54764424	54764444	73269	hg19	N/A	N/A	N/A	Enhatls6574	enhancer	enh				GACTCCCAGACCTGAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-1.120886366	PARS2	chr1	54756897	54764523	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6030
enhrx-6031	chr1	55230102	55230123	54764429	54764450	73270	hg19	N/A	N/A	N/A	Enhatls6574	enhancer	enh				GTGGGTGACTCCCAGACCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-2.53009737	PARS2	chr1	54756897	54764523	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6030
enhrx-6031	chr1	55230121	55230141	54764448	54764468	73271	hg19	N/A	N/A	N/A	Enhatls6574	enhancer	enh				GGATTGCGGTAGGTGAACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-1.982916533	PARS2	chr1	54756897	54764523	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6030
enhrx-lit1700	chr1	55230171	55230191	54764498	54764518	73272	hg19					enhancer	enh				GCAAGCGCGCTGGCCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-2.849600699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1701	chr1	55230171	55230193	54764498	54764520	73273	hg19					enhancer	enh				GCGCAAGCGCGCTGGCCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-1.440488705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1702	chr1	55230176	55230196	54764503	54764523	73274	hg19					enhancer	enh				GAGGCGCAAGCGCGCTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				0.190228064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1703	chr1	55230195	55230216	54764522	54764543	73275	hg19					enhancer	enh				GCTTAGGAGCGGGCTTGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-1.537274958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1704	chr1	55230195	55230217	54764522	54764544	73276	hg19					enhancer	enh				GGCTTAGGAGCGGGCTTGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-1.021554434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1705	chr1	55230223	55230244	54764550	54764571	73277	hg19					enhancer	enh				GCAATTGGCGAAAAGGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PARS2	indirect	Non Significant	NA				-0.981697107									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1706	chr1	55680934	55680955	55215261	55215282	73278	hg19					enhancer	enh				GACCCAAGCCCGCACCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.236571247									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1707	chr1	55680951	55680973	55215278	55215300	73279	hg19					enhancer	enh				GGTCCTGCGAGCCGAGCTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.694424328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1708	chr1	55680952	55680973	55215279	55215300	73280	hg19					enhancer	enh				GTCCTGCGAGCCGAGCTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.636496263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1709	chr1	55680957	55680978	55215284	55215305	73281	hg19					enhancer	enh				GCGAGCCGAGCTAGTGCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.418693202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1710	chr1	55680964	55680986	55215291	55215313	73282	hg19					enhancer	enh				GAGCTAGTGCGGTGAGGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.792325642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1711	chr1	55680965	55680986	55215292	55215313	73283	hg19					enhancer	enh				GAGCGCCTCACCGCACTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	indirect	Non Significant	NA				-0.144020423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1712	chr1	55680966	55680986	55215293	55215313	73284	hg19					enhancer	enh				GCTAGTGCGGTGAGGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.733306142									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1713	chr1	55680977	55680997	55215304	55215324	73285	hg19					enhancer	enh				GAGGCGCTCAGGCGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	indirect	Non Significant	NA				-0.422449062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1714	chr1	55680980	55681002	55215307	55215329	73286	hg19					enhancer	enh				GCGCTCAGGCGCGGCTGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	indirect	Non Significant	NA				0.078172105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1715	chr1	55680982	55681002	55215309	55215329	73287	hg19					enhancer	enh				GCTCAGGCGCGGCTGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.218223564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1716	chr1	55681013	55681033	55215340	55215360	73288	hg19					enhancer	enh				GGCCAACATGGCGGCGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.381603792									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1717	chr1	55681013	55681035	55215340	55215362	73289	hg19					enhancer	enh				GAGGCCAACATGGCGGCGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	indirect	Non Significant	NA				-0.505190396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1718	chr1	55681045	55681066	55215372	55215393	73290	hg19					enhancer	enh				GCCTCCTCCTCCCCGGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	indirect	Non Significant	NA				0.061065647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1719	chr1	55681045	55681065	55215372	55215392	73291	hg19					enhancer	enh				GCCTCCTCCTCCCCGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.222223441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1720	chr1	55681099	55681119	55215426	55215446	73292	hg19					enhancer	enh				GAGGCGACCGTGCTCGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.29064683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1721	chr1	55681189	55681210	55215516	55215537	73293	hg19					enhancer	enh				GCGGAGCGTGCCTAAGGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	USP24	direct	Highly Significant	NA				0.579353995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-6206	chr1	59012316	59012337	58546644	58546665	73294	hg19	N/A	N/A	N/A	Enhatls6757	enhancer	enh				GAGTAGGATCGTGCCCAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-1.392050459	OMA1	chr1	58467926	58546802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6205
enhrx-6206	chr1	59012323	59012345	58546651	58546673	73295	hg19	N/A	N/A	N/A	Enhatls6757	enhancer	enh				GCACGATCCTACTCGGAAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.395880524	OMA1	chr1	58467926	58546802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6205
enhrx-6206	chr1	59012327	59012347	58546655	58546675	73296	hg19	N/A	N/A	N/A	Enhatls6757	enhancer	enh				GATCCTACTCGGAAAAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.281908771	OMA1	chr1	58467926	58546802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6205
enhrx-6206	chr1	59012343	59012365	58546671	58546693	73297	hg19	N/A	N/A	N/A	Enhatls6757	enhancer	enh				GCTGGGGAAAAGCGTCACCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.801430963	OMA1	chr1	58467926	58546802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6205
enhrx-6206	chr1	59012371	59012391	58546699	58546719	73298	hg19	N/A	N/A	N/A	Enhatls6757	enhancer	enh				GACTCAAGCAGAAGCGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.408594722	OMA1	chr1	58467926	58546802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6205
enhrx-lit1722	chr1	59012409	59012431	58546737	58546759	73299	hg19					enhancer	enh				GGTGCGCGCCTGCGCATAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				0.192726564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1723	chr1	59012409	59012430	58546737	58546758	73300	hg19					enhancer	enh				GTGCGCGCCTGCGCATAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				0.109863575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1724	chr1	59012410	59012430	58546738	58546758	73301	hg19					enhancer	enh				GTGCGCGCCTGCGCATAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.083251766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1725	chr1	59012414	59012434	58546742	58546762	73302	hg19					enhancer	enh				GCGGGTGCGCGCCTGCGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.205583867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1726	chr1	59012432	59012452	58546760	58546780	73303	hg19					enhancer	enh				GCACTTCCTGCCCGCCATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.385735809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1727	chr1	59012445	59012465	58546773	58546793	73304	hg19					enhancer	enh				GGCGCCCCGGCCGGTATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	direct	Highly Significant	NA				0.241919452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1728	chr1	59012505	59012525	58546833	58546853	73305	hg19					enhancer	enh				GGCAGCTGGGAGAACGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.062668389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1729	chr1	59012534	59012556	58546862	58546884	73306	hg19					enhancer	enh				GCTAGAGCGCCACAGTCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.135011379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1730	chr1	59012545	59012565	58546873	58546893	73307	hg19					enhancer	enh				GGCGCTCTAGCGCCTCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.271098682									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1731	chr1	59012554	59012575	58546882	58546903	73308	hg19					enhancer	enh				GCGCCTCCGTGTGGCTTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.091592171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1732	chr1	59012562	59012582	58546890	58546910	73309	hg19					enhancer	enh				GTGTGGCTTAAGGCGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OMA1	indirect	Non Significant	NA				-0.886776056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1733	chr1	62190696	62190717	61725024	61725045	73310	hg19					enhancer	enh				GTCTCAGTCACTACAGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.613170949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1734	chr1	62190703	62190724	61725031	61725052	73311	hg19					enhancer	enh				GTAGTGACTGAGACGAACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-2.41579616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1735	chr1	62190723	62190744	61725051	61725072	73312	hg19					enhancer	enh				GCCAGACTCGTTGGTGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.854601088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1736	chr1	62190735	62190756	61725063	61725084	73313	hg19					enhancer	enh				GAGTCTGGCCGTCACGGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				0.192218895									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1737	chr1	62190746	62190766	61725074	61725094	73314	hg19					enhancer	enh				GTCTGCTCCGGAGGCCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.726001736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1738	chr1	62190755	62190775	61725083	61725103	73315	hg19					enhancer	enh				GTCTGGTCCGTCTGCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.962889047									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1739	chr1	62190758	62190778	61725086	61725106	73316	hg19					enhancer	enh				GCCGTCTGGTCCGTCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.635387355									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1740	chr1	62190760	62190782	61725088	61725110	73317	hg19					enhancer	enh				GCAGACGGACCAGACGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	direct	Highly Significant	NA				0.213142593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1741	chr1	62190772	62190793	61725100	61725121	73318	hg19					enhancer	enh				GATGGCGGCCGCCTGGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				0.090026715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1742	chr1	62190780	62190802	61725108	61725130	73319	hg19					enhancer	enh				GGTCTCCAAGATGGCGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				0.109967578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1743	chr1	62190780	62190801	61725108	61725129	73320	hg19					enhancer	enh				GTCTCCAAGATGGCGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				0.137421935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1744	chr1	62190791	62190813	61725119	61725141	73321	hg19					enhancer	enh				GAGAAAGTGTCGGTCTCCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.405362223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1745	chr1	62190791	62190811	61725119	61725139	73322	hg19					enhancer	enh				GAAAGTGTCGGTCTCCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				0.105678055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1746	chr1	62190822	62190844	61725150	61725172	73323	hg19					enhancer	enh				GCTTCCGCCTCCGCCCAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.078800146									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1747	chr1	62190822	62190843	61725150	61725171	73324	hg19					enhancer	enh				GCTTCCGCCTCCGCCCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.34014955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1748	chr1	62190828	62190848	61725156	61725176	73325	hg19					enhancer	enh				GCCTCCGCCCAGGAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.633392004									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1749	chr1	62190839	62190859	61725167	61725187	73326	hg19					enhancer	enh				GCCCTTCTCCCTCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TM2D1	indirect	Non Significant	NA				-0.29319902									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1750	chr1	75198841	75198861	74733157	74733177	73327	hg19					enhancer	enh				GGCCACCGCTCGCTTCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				0.124400277									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1751	chr1	75198846	75198868	74733162	74733184	73328	hg19					enhancer	enh				GCAGCCATATTGAAGCGAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	direct	Highly Significant	NA				0.586801561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1752	chr1	75198849	75198869	74733165	74733185	73329	hg19					enhancer	enh				GGCAGCCATATTGAAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.050608248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1753	chr1	75198849	75198870	74733165	74733186	73330	hg19					enhancer	enh				GGGCAGCCATATTGAAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-1.277195987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1754	chr1	75198870	75198890	74733186	74733206	73331	hg19					enhancer	enh				GTAGCCTCGTCTCTCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.248110538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1755	chr1	75198874	75198895	74733190	74733211	73332	hg19					enhancer	enh				GGAGAGACGAGGCTACCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	direct	Highly Significant	NA				0.337444735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1756	chr1	75198915	75198935	74733231	74733251	73333	hg19					enhancer	enh				GATCCATGGGTGACGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.709863159									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1757	chr1	75198915	75198937	74733231	74733253	73334	hg19					enhancer	enh				GCGATCCATGGGTGACGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.002164052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1758	chr1	75198921	75198941	74733237	74733257	73335	hg19					enhancer	enh				GTCACCCATGGATCGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				0.000138507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1759	chr1	75198928	75198949	74733244	74733265	73336	hg19					enhancer	enh				GAACTCCGCGCTGCGATCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.17707509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1760	chr1	75198929	75198949	74733245	74733265	73337	hg19					enhancer	enh				GAACTCCGCGCTGCGATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	direct	Highly Significant	NA				0.288753135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1761	chr1	75198960	75198980	74733276	74733296	73338	hg19					enhancer	enh				GGCGCAATGTTTGAGCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				0.195016101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1762	chr1	75198974	75198995	74733290	74733311	73339	hg19					enhancer	enh				GCAAAGCGGACCTCAGCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				0.102597955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1763	chr1	75198989	75199010	74733305	74733326	73340	hg19					enhancer	enh				GCCGGAAGGGCAGTGTTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TYW3	indirect	Non Significant	NA				-0.007119498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1764	chr1	78354021	78354041	77888336	77888356	73341	hg19					enhancer	enh				GAGGCAGGCCCAAAGTTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.305922675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1765	chr1	78354040	78354060	77888355	77888375	73342	hg19					enhancer	enh				GGGGTCAGCTCGCGCACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				0.111864283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1766	chr1	78354073	78354093	77888388	77888408	73343	hg19					enhancer	enh				GACAAATTCTGGCGGAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.461459005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1767	chr1	78354141	78354161	77888456	77888476	73344	hg19					enhancer	enh				GCCGTTATCACCCGGAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-3.071948163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1768	chr1	78354189	78354211	77888504	77888526	73345	hg19					enhancer	enh				GCTGCAGCTGTTCCAAAACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				0.069303384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1769	chr1	78354197	78354218	77888512	77888533	73346	hg19					enhancer	enh				GGAACAGCTGCAGCCGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.173397567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1770	chr1	78354198	78354218	77888513	77888533	73347	hg19					enhancer	enh				GAACAGCTGCAGCCGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.1029724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1771	chr1	78354213	78354235	77888528	77888550	73348	hg19					enhancer	enh				GCATTCCAGGCGGGCCCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-1.056904967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1772	chr1	78354213	78354234	77888528	77888549	73349	hg19					enhancer	enh				GCGCTGGGCCCGCCTGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.081265441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1773	chr1	78354219	78354241	77888534	77888556	73350	hg19					enhancer	enh				GGCCCGCCTGGAATGCGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	direct	Highly Significant	NA				0.58286241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1774	chr1	78354220	78354241	77888535	77888556	73351	hg19					enhancer	enh				GCCCGCCTGGAATGCGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.318520709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1775	chr1	78354224	78354245	77888539	77888560	73352	hg19					enhancer	enh				GCCTGTTCCCGCATTCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				0.020430408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1776	chr1	78354225	78354245	77888540	77888560	73353	hg19					enhancer	enh				GCCTGTTCCCGCATTCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				0.123446809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1777	chr1	78354233	78354253	77888548	77888568	73354	hg19					enhancer	enh				GCGGGAACAGGCTGCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				0.091353854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1778	chr1	78354254	78354274	77888569	77888589	73355	hg19					enhancer	enh				GCAAGTTTCCATAAAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	indirect	Non Significant	NA				-0.546322043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1779	chr1	78354265	78354286	77888580	77888601	73356	hg19					enhancer	enh				GAAACTTGCTGCTGGAGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	direct	Highly Significant	NA				0.41277595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1780	chr1	78354313	78354335	77888628	77888650	73357	hg19					enhancer	enh				GCTCCAGCCGCTGGGAGTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	direct	Highly Significant	NA				0.451196874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1781	chr1	78354373	78354393	77888688	77888708	73358	hg19					enhancer	enh				GTGCGCGTCCCGCCTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEXN	direct	Highly Significant	NA				0.207857873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1782	chr1	89458262	89458284	88992579	88992601	73359	hg19					enhancer	enh				GTTCCCGCACCGGATAGGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.128197093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1783	chr1	89458269	89458289	88992586	88992606	73360	hg19					enhancer	enh				GCGAGGTTCCCGCACCGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.094103043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1784	chr1	89458274	89458294	88992591	88992611	73361	hg19					enhancer	enh				GGGAGGCGAGGTTCCCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.27009111									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1785	chr1	89458309	89458329	88992626	88992646	73362	hg19					enhancer	enh				GCCGGGCCCTCAAGCCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	direct	Highly Significant	NA				0.665419119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1786	chr1	89458357	89458377	88992674	88992694	73363	hg19					enhancer	enh				GCCGGGACAGGGATTGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	direct	Highly Significant	NA				0.297207448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1787	chr1	89458410	89458432	88992727	88992749	73364	hg19					enhancer	enh				GGGTAGGCCAGGATCTCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.032792935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1788	chr1	89458411	89458432	88992728	88992749	73365	hg19					enhancer	enh				GGTAGGCCAGGATCTCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.123614056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1789	chr1	89458412	89458432	88992729	88992749	73366	hg19					enhancer	enh				GTAGGCCAGGATCTCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.349796566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1790	chr1	89458420	89458442	88992737	88992759	73367	hg19					enhancer	enh				GGATCTCTAGGCTGGAAGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.061859479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1791	chr1	89458420	89458442	88992737	88992759	73368	hg19					enhancer	enh				GTCTCTTCCAGCCTAGAGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.20449275									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1792	chr1	89458488	89458508	88992805	88992825	73369	hg19					enhancer	enh				GTTCCGGGCTTGCGGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	direct	Highly Significant	NA				0.384283932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1793	chr1	89458523	89458543	88992840	88992860	73370	hg19					enhancer	enh				GGCGAGCCCGGATGTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				0.0924196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1794	chr1	89458560	89458581	88992877	88992898	73371	hg19					enhancer	enh				GTGACTCACGGCGCGCGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				0.11729997									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1795	chr1	89458582	89458602	88992899	88992919	73372	hg19					enhancer	enh				GGTGGGGTCCGCCGCGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				-0.18425538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1796	chr1	89458587	89458607	88992904	88992924	73373	hg19					enhancer	enh				GGTCCGCCGCGATCGCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	indirect	Non Significant	NA				0.134754187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1797	chr1	89458597	89458617	88992914	88992934	73374	hg19					enhancer	enh				GATCGCGGAATGGATGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBMXL1	direct	Highly Significant	NA				0.362256446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1798	chr1	91183013	91183035	90717456	90717478	73375	hg19					enhancer	enh				GAAAACTCGGAACTTGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.036669428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1799	chr1	91183037	91183057	90717480	90717500	73376	hg19					enhancer	enh				GAACGACTGCGCACGTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.570909405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1800	chr1	91183073	91183093	90717516	90717536	73377	hg19					enhancer	enh				GAGGACCCAGGCGAAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.442541653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1801	chr1	91183097	91183117	90717540	90717560	73378	hg19					enhancer	enh				GAAGGCGAAGGCGCAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	direct	Highly Significant	NA				0.214950379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1802	chr1	91183109	91183129	90717552	90717572	73379	hg19					enhancer	enh				GCAGGCGAAGGCGAAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	direct	Highly Significant	NA				0.658336973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1803	chr1	91183162	91183182	90717605	90717625	73380	hg19					enhancer	enh				GCAGACCCCGGCAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-1.183888857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1804	chr1	91183165	91183186	90717608	90717629	73381	hg19					enhancer	enh				GTGGGCAGACCCCGGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.557074589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1805	chr1	91183168	91183189	90717611	90717632	73382	hg19					enhancer	enh				GCTGTGGGCAGACCCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	direct	Highly Significant	NA				0.303862604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1806	chr1	91183174	91183194	90717617	90717637	73383	hg19					enhancer	enh				GCCAGGCTGTGGGCAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.469686936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1807	chr1	91183176	91183196	90717619	90717639	73384	hg19					enhancer	enh				GTCTGCCCACAGCCTGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.04232521									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1808	chr1	91183180	91183200	90717623	90717643	73385	hg19					enhancer	enh				GCCCACAGCCTGGCACCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.333126872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1809	chr1	91183185	91183207	90717628	90717650	73386	hg19					enhancer	enh				GCTGCCGCCCGGTGCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.233527513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1810	chr1	91183187	91183209	90717630	90717652	73387	hg19					enhancer	enh				GCCTGGCACCGGGCGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	direct	Highly Significant	NA				0.227694632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1811	chr1	91183191	91183213	90717634	90717656	73388	hg19					enhancer	enh				GCCACCGCTGCCGCCCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.328191993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1812	chr1	91183229	91183249	90717672	90717692	73389	hg19					enhancer	enh				GGTGCAGCGACCGCGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BARHL2	indirect	Non Significant	NA				-0.181811877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1813	chr1	91487402	91487422	91021845	91021865	73390	hg19					enhancer	enh				GGCCCGGGGAGCTACGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.208176899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1814	chr1	91487483	91487505	91021926	91021948	73391	hg19					enhancer	enh				GCCCAGAGGCCCGAAACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.346970547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1815	chr1	91487514	91487535	91021957	91021978	73392	hg19					enhancer	enh				GGGTTATTTGGTCAGATTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.047389194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1816	chr1	91487535	91487557	91021978	91022000	73393	hg19					enhancer	enh				GGCACCAAACTGTGAGTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.213539562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1817	chr1	91487535	91487556	91021978	91021999	73394	hg19					enhancer	enh				GCACCAAACTGTGAGTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.131130549									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1818	chr1	91487551	91487572	91021994	91022015	73395	hg19					enhancer	enh				GGTGCCGTGTGCGTCAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.072624765									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1819	chr1	91487552	91487572	91021995	91022015	73396	hg19					enhancer	enh				GTGCCGTGTGCGTCAAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				0.130890622									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1820	chr1	91487558	91487579	91022001	91022022	73397	hg19					enhancer	enh				GTCGCCCCGGTTTGACGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.479725939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1821	chr1	91487559	91487581	91022002	91022024	73398	hg19					enhancer	enh				GTGCGTCAAACCGGGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.011758216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1822	chr1	91487561	91487581	91022004	91022024	73399	hg19					enhancer	enh				GCGTCAAACCGGGGCGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	direct	Highly Significant	NA				0.245895974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1823	chr1	91487572	91487592	91022015	91022035	73400	hg19					enhancer	enh				GCGTGCTCCCAACGTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.342428386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1824	chr1	91487600	91487622	91022043	91022065	73401	hg19					enhancer	enh				GTACAGAGCGGCGTGTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.389937264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1825	chr1	91487614	91487635	91022057	91022078	73402	hg19					enhancer	enh				GGAGCCGAGTAGCGTACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.238665949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1826	chr1	91487614	91487634	91022057	91022077	73403	hg19					enhancer	enh				GAGCCGAGTAGCGTACAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	direct	Highly Significant	NA				0.485138983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1827	chr1	91487747	91487767	91022190	91022210	73404	hg19					enhancer	enh				GCTCCCGGGAAGCTTCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF644	indirect	Non Significant	NA				-0.252936583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1828	chr1	92764476	92764497	92298919	92298940	73405	hg19					enhancer	enh				GCGAGGGTTCTGGCCGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLMN	indirect	Non Significant	NA				-2.324116029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1829	chr1	92764554	92764574	92298997	92299017	73406	hg19					enhancer	enh				GCCTCCCTACGCGTAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLMN	indirect	Non Significant	NA				-0.641612859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1830	chr1	92941413	92941435	92475856	92475878	73407	hg19					enhancer	enh				GCAGCTCCAGGAGGTAAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.576997706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1831	chr1	92941449	92941470	92475892	92475913	73408	hg19					enhancer	enh				GTCCAGTCTGCAGATCCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.081187013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1832	chr1	92941509	92941529	92475952	92475972	73409	hg19					enhancer	enh				GGAGCAGAGTGGTGGCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.900300292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1833	chr1	92941542	92941563	92475985	92476006	73410	hg19					enhancer	enh				GCAGCTACACAACACTACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	direct	Highly Significant	NA				0.208163504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1834	chr1	92941543	92941563	92475986	92476006	73411	hg19					enhancer	enh				GCAGCTACACAACACTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	direct	Highly Significant	NA				0.885665346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1835	chr1	92941558	92941579	92476001	92476022	73412	hg19					enhancer	enh				GCTGCTGCTTGCAGCCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.121382068									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1836	chr1	92941558	92941578	92476001	92476021	73413	hg19					enhancer	enh				GCTGCTGCTTGCAGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	direct	Highly Significant	NA				0.261455131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1837	chr1	92941575	92941595	92476018	92476038	73414	hg19					enhancer	enh				GCTCAAATGAGCACCCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.255196087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1838	chr1	92941575	92941596	92476018	92476039	73415	hg19					enhancer	enh				GGCTCAAATGAGCACCCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				0.189131919									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1839	chr1	92941579	92941601	92476022	92476044	73416	hg19					enhancer	enh				GCATGGGCTCAAATGAGCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				0.066683944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1840	chr1	92941597	92941617	92476040	92476060	73417	hg19					enhancer	enh				GGCACCGGGAGACGCAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.248264873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1841	chr1	92941598	92941620	92476041	92476063	73418	hg19					enhancer	enh				GAAGGCACCGGGAGACGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.517554433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1842	chr1	92941602	92941622	92476045	92476065	73419	hg19					enhancer	enh				GCGTCTCCCGGTGCCTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				0.016284994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1843	chr1	92941611	92941631	92476054	92476074	73420	hg19					enhancer	enh				GGTGGACCTCCGAAGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	indirect	Non Significant	NA				-0.387012955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1844	chr1	92941720	92941742	92476163	92476185	73421	hg19					enhancer	enh				GCTGAATGCCTTGCCGCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GFI1	direct	Highly Significant	NA				0.232532368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1845	chr1	101360191	101360211	100894635	100894655	73422	hg19					enhancer	enh				GAGTGCAGTAGATTGCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.114734657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1846	chr1	101360217	101360238	100894661	100894682	73423	hg19					enhancer	enh				GCTGCAGGGAAATAAATCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				0.132689944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1847	chr1	101360236	101360257	100894680	100894701	73424	hg19					enhancer	enh				GCTTAGTTATCATAAAACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				0.002348157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1848	chr1	101360308	101360330	100894752	100894774	73425	hg19					enhancer	enh				GCATCTATCCTTCTCCATTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				0.072157892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1849	chr1	101360319	101360339	100894763	100894783	73426	hg19					enhancer	enh				GTTAATCCAGCTAATGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.015970335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1850	chr1	101360353	101360374	100894797	100894818	73427	hg19					enhancer	enh				GCCGCCCGCAAAGTGAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.274635676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1851	chr1	101360360	101360382	100894804	100894826	73428	hg19					enhancer	enh				GCAAAGTGAGCGCCTGGAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.317512913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1852	chr1	101360360	101360381	100894804	100894825	73429	hg19					enhancer	enh				GCAAAGTGAGCGCCTGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.637125193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1853	chr1	101360375	101360397	100894819	100894841	73430	hg19					enhancer	enh				GGAGCAAGGGACAGTCCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	direct	Highly Significant	NA				0.487290051									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1854	chr1	101360376	101360397	100894820	100894841	73431	hg19					enhancer	enh				GAGCAAGGGACAGTCCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.57252645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1855	chr1	101360394	101360415	100894838	100894859	73432	hg19					enhancer	enh				GAAAGGGAGGGGCGGCCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.797383356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1856	chr1	101360395	101360415	100894839	100894859	73433	hg19					enhancer	enh				GAAAGGGAGGGGCGGCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.018121018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1857	chr1	101360403	101360423	100894847	100894867	73434	hg19					enhancer	enh				GCGTCACCGAAAGGGAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	direct	Highly Significant	NA				1.679774735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1858	chr1	101360406	101360426	100894850	100894870	73435	hg19					enhancer	enh				GGAGCGTCACCGAAAGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	direct	Highly Significant	NA				0.378576761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1859	chr1	101360406	101360428	100894850	100894872	73436	hg19					enhancer	enh				GTGGAGCGTCACCGAAAGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.157333564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1860	chr1	101360408	101360428	100894852	100894872	73437	hg19					enhancer	enh				GTGGAGCGTCACCGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	direct	Highly Significant	NA				0.835894444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1861	chr1	101360411	101360431	100894855	100894875	73438	hg19					enhancer	enh				GAAGTGGAGCGTCACCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				-0.327638559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1862	chr1	101360433	101360454	100894877	100894898	73439	hg19					enhancer	enh				GTCGGCCTAAAAGGCATTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				0.007496399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1863	chr1	101360483	101360505	100894927	100894949	73440	hg19					enhancer	enh				GAAAGGATTGGCTTTCGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EXTL2	indirect	Non Significant	NA				0.073104245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-8530	chr1	108011868	108011890	107469246	107469268	73441	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GTTTGATAATGGAAGCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-0.451145129	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011892	108011912	107469270	107469290	73442	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GTCAAAGATTCCCATACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-0.186019272	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011926	108011948	107469304	107469326	73443	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GCTTTGACTTGCCAACTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-0.020774434	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011966	108011988	107469344	107469366	73444	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GGAGAGGGAGCTAACTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	direct	Highly Significant	NA				0.39013427	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011966	108011987	107469344	107469365	73445	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GAGAGGGAGCTAACTAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-0.411909797	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011989	108012011	107469367	107469389	73446	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GGAAAATTATTTGGCAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-1.266014265	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011989	108012010	107469367	107469388	73447	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GAAAATTATTTGGCAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				0.139808851	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108011996	108012016	107469374	107469394	73448	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GAAAGGGAAAATTATTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	direct	Highly Significant	NA				0.41347762	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108012042	108012062	107469420	107469440	73449	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GACATCCACCATTCGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				0.123259325	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-8530	chr1	108012050	108012070	107469428	107469448	73450	hg19	N/A	N/A	N/A	Enhatls9212	enhancer	enh				GTATGCCTGTTTCCGAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NTNG1	indirect	Non Significant	NA				-0.602903836	NTNG1	chr1	107140006	107484923	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8529
enhrx-lit1864	chr1	109102541	109102561	108559919	108559939	73451	hg19					enhancer	enh				GACGTGCTAACTGCCGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	direct	Highly Significant	NA				0.37591225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1865	chr1	109102557	109102578	108559935	108559956	73452	hg19					enhancer	enh				GCCGCGGACTCTAACCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.024886264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1866	chr1	109102675	109102696	108560053	108560074	73453	hg19					enhancer	enh				GGAACCGCCGCCTCAGCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	direct	Highly Significant	NA				0.237931395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1867	chr1	109102675	109102695	108560053	108560073	73454	hg19					enhancer	enh				GAACCGCCGCCTCAGCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.259110991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1868	chr1	109102705	109102725	108560083	108560103	73455	hg19					enhancer	enh				GCCTCTCCCGACTCCCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.080567796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1869	chr1	109102709	109102729	108560087	108560107	73456	hg19					enhancer	enh				GCCCGTCTGGGAGTCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	direct	Highly Significant	NA				0.286562809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1870	chr1	109102714	109102734	108560092	108560112	73457	hg19					enhancer	enh				GACTCCCAGACGGGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				0.115306379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1871	chr1	109102715	109102735	108560093	108560113	73458	hg19					enhancer	enh				GCTGCCGCCCGTCTGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				0.055712575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1872	chr1	109102759	109102781	108560137	108560159	73459	hg19					enhancer	enh				GGCGGCGAGCTGAGCACCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.003801349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1873	chr1	109102760	109102781	108560138	108560159	73460	hg19					enhancer	enh				GCGGCGAGCTGAGCACCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	direct	Highly Significant	NA				0.330232358									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1874	chr1	109102760	109102780	108560138	108560158	73461	hg19					enhancer	enh				GCGGCGAGCTGAGCACCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				0.007182733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1875	chr1	109102796	109102817	108560174	108560195	73462	hg19					enhancer	enh				GGTCGTGCTGCAGCTCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	direct	Highly Significant	NA				0.254077105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1876	chr1	109102796	109102816	108560174	108560194	73463	hg19					enhancer	enh				GTCGTGCTGCAGCTCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.468626805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1877	chr1	109102803	109102825	108560181	108560203	73464	hg19					enhancer	enh				GCTGCAGCACGACCGCTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.202043785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1878	chr1	109102809	109102829	108560187	108560207	73465	hg19					enhancer	enh				GCACGACCGCTCCCCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.367033669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1879	chr1	109102813	109102833	108560191	108560211	73466	hg19					enhancer	enh				GACCGCTCCCCGCGGGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				-0.14590692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1880	chr1	109102856	109102877	108560234	108560255	73467	hg19					enhancer	enh				GCAGCCTGGGCCGGAACGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM102B	indirect	Non Significant	NA				0.165816176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1881	chr1	110453402	110453423	109910780	109910801	73468	hg19					enhancer	enh				GTGGTTTATGGGAAATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-2.202220234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1882	chr1	110453451	110453471	109910829	109910849	73469	hg19					enhancer	enh				GTGCCGAGGGCTGGCCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				0.02463763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1883	chr1	110453456	110453476	109910834	109910854	73470	hg19					enhancer	enh				GAGGGCTGGCCAGTGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.27376681									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1884	chr1	110453460	110453481	109910838	109910859	73471	hg19					enhancer	enh				GCTGGCCAGTGAGGCTCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.09634151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1885	chr1	110453463	110453483	109910841	109910861	73472	hg19					enhancer	enh				GGCCAGTGAGGCTCGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				0.448227457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1886	chr1	110453482	110453502	109910860	109910880	73473	hg19					enhancer	enh				GGCAAACTTTCACTTTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				0.11973098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1887	chr1	110453482	110453502	109910860	109910880	73474	hg19					enhancer	enh				GGGGAAAGTGAAAGTTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.648540033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1888	chr1	110453503	110453524	109910881	109910902	73475	hg19					enhancer	enh				GCTCTGGCGCCGAGAGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.060491894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1889	chr1	110453503	110453525	109910881	109910903	73476	hg19					enhancer	enh				GGCTCTGGCGCCGAGAGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.683194513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1890	chr1	110453510	110453531	109910888	109910909	73477	hg19					enhancer	enh				GAGAGCGGCTCTGGCGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				0.309392245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1891	chr1	110453525	110453546	109910903	109910924	73478	hg19					enhancer	enh				GCTCTCCGCATCCCAGGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.092630588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1892	chr1	110453533	110453555	109910911	109910933	73479	hg19					enhancer	enh				GCCGCACCGCTGTCCTGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				0.285295086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1893	chr1	110453540	110453562	109910918	109910940	73480	hg19					enhancer	enh				GCCGAGGGCCGCACCGCTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				0.17370453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1894	chr1	110453541	110453562	109910919	109910940	73481	hg19					enhancer	enh				GACAGCGGTGCGGCCCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.280148784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1895	chr1	110453557	110453577	109910935	109910955	73482	hg19					enhancer	enh				GGAGTGGGCGCCCCGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				0.459417412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1896	chr1	110453572	110453593	109910950	109910971	73483	hg19					enhancer	enh				GCTCGCTGGCTGCTGCGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.42753208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1897	chr1	110453629	110453650	109911007	109911028	73484	hg19					enhancer	enh				GTCATACGGGCAGCTGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				0.497549378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1898	chr1	110453636	110453656	109911014	109911034	73485	hg19					enhancer	enh				GCTGCCCGTATGACCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	direct	Highly Significant	NA				1.022267726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1899	chr1	110453643	110453663	109911021	109911041	73486	hg19					enhancer	enh				GGCGCCCGGCGCGGTCATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CSF1	indirect	Non Significant	NA				-0.203749084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1900	chr1	110527353	110527373	109984731	109984751	73487	hg19					enhancer	enh				GGTGACGCCACGTCAAGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-2.16915126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1901	chr1	110527377	110527397	109984755	109984775	73488	hg19					enhancer	enh				GCACGCAAAGCGAGGGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-3.339391654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1902	chr1	110527384	110527405	109984762	109984783	73489	hg19					enhancer	enh				GCAAACACGCACGCAAAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.378770845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1903	chr1	110527385	110527405	109984763	109984783	73490	hg19					enhancer	enh				GCAAACACGCACGCAAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.172145573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1904	chr1	110527391	110527411	109984769	109984789	73491	hg19					enhancer	enh				GCGTGCGTGTTTGCGTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.7854372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1905	chr1	110527393	110527414	109984771	109984792	73492	hg19					enhancer	enh				GTGCGTGTTTGCGTACAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-3.261716737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1906	chr1	110527397	110527417	109984775	109984795	73493	hg19					enhancer	enh				GTGTTTGCGTACAGCGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.849381297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1907	chr1	110527475	110527497	109984853	109984875	73494	hg19					enhancer	enh				GCCCAAGGCAGCCGGACAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.565952671									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1908	chr1	110527488	110527510	109984866	109984888	73495	hg19					enhancer	enh				GCCTTGGGCTGCCGAACAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.405044752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1909	chr1	110527495	110527516	109984873	109984894	73496	hg19					enhancer	enh				GCTGCCGAACAGACAAGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.260449148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1910	chr1	110527532	110527553	109984910	109984931	73497	hg19					enhancer	enh				GAAGCCGACGCAGCTCGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-0.170376096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1911	chr1	110527539	110527559	109984917	109984937	73498	hg19					enhancer	enh				GCCCCTGCGTCGAGCTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-0.282667149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1912	chr1	110527569	110527589	109984947	109984967	73499	hg19					enhancer	enh				GTGGGCGATCGCGTGTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AHCYL1	indirect	Non Significant	NA				-1.186665316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1913	chr1	110882010	110882030	110339388	110339408	73500	hg19					enhancer	enh				GAGAGAGCAATTGGCCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	direct	Highly Significant	NA				0.218457213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1914	chr1	110882016	110882038	110339394	110339416	73501	hg19					enhancer	enh				GCAATTGGCCAATGAGGACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.273661404									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1915	chr1	110882016	110882037	110339394	110339415	73502	hg19					enhancer	enh				GCAATTGGCCAATGAGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	direct	Highly Significant	NA				0.206409205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1916	chr1	110882022	110882042	110339400	110339420	73503	hg19					enhancer	enh				GGCCAATGAGGACTGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.833836062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1917	chr1	110882023	110882043	110339401	110339421	73504	hg19					enhancer	enh				GCCAATGAGGACTGCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	direct	Highly Significant	NA				0.276020293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1918	chr1	110882040	110882060	110339418	110339438	73505	hg19					enhancer	enh				GGCGGGACCCTGTGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.444093028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1919	chr1	110882051	110882072	110339429	110339450	73506	hg19					enhancer	enh				GTGCCGCGGCGGAGTCCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.047240414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1920	chr1	110882053	110882075	110339431	110339453	73507	hg19					enhancer	enh				GCCGCGGCGGAGTCCAAGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.145082175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1921	chr1	110882057	110882079	110339435	110339457	73508	hg19					enhancer	enh				GCCGCCATCTTGGACTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	direct	Highly Significant	NA				0.929049398									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1922	chr1	110882061	110882082	110339439	110339460	73509	hg19					enhancer	enh				GGAGTCCAAGATGGCGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.286835723									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1923	chr1	110882062	110882082	110339440	110339460	73510	hg19					enhancer	enh				GAGTCCAAGATGGCGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.1811658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1924	chr1	110882084	110882106	110339462	110339484	73511	hg19					enhancer	enh				GTTCCGCTGTGTGAAACGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-1.567647146									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1925	chr1	110882090	110882112	110339468	110339490	73512	hg19					enhancer	enh				GCCCCGCGCTCGTTTCACACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				0.152294489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1926	chr1	110882109	110882131	110339487	110339509	73513	hg19					enhancer	enh				GGCGGCGGGTTACTCAGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.682583081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1927	chr1	110882110	110882131	110339488	110339509	73514	hg19					enhancer	enh				GCGGCGGGTTACTCAGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-1.197588421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1928	chr1	110882131	110882152	110339509	110339530	73515	hg19					enhancer	enh				GGTCGTCGGAGGTCGTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	direct	Highly Significant	NA				0.277443305									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1929	chr1	110882131	110882151	110339509	110339529	73516	hg19					enhancer	enh				GTCGTCGGAGGTCGTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM15	indirect	Non Significant	NA				-0.552128822									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1930	chr1	113615786	113615806	113073164	113073184	73517	hg19					enhancer	enh				GCGCAACGTCCTCACGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				0.176426869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1931	chr1	113615789	113615809	113073167	113073187	73518	hg19					enhancer	enh				GCGTGAGGACGTTGCGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				-0.169593265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1932	chr1	113615816	113615837	113073194	113073215	73519	hg19					enhancer	enh				GGCGGACGAGAGGTGTCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				-0.099336431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1933	chr1	113615817	113615837	113073195	113073215	73520	hg19					enhancer	enh				GCGGACGAGAGGTGTCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.898181108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1934	chr1	113615830	113615851	113073208	113073229	73521	hg19					enhancer	enh				GTCCGTCAGGCCGTGTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.272423443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1935	chr1	113615835	113615856	113073213	113073234	73522	hg19					enhancer	enh				GGCCTGGGACACACGGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.346217254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1936	chr1	113615835	113615855	113073213	113073233	73523	hg19					enhancer	enh				GCCTGGGACACACGGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.458369384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1937	chr1	113615843	113615863	113073221	113073241	73524	hg19					enhancer	enh				GGTCGACGGCCTGGGACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.618063398									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1938	chr1	113615851	113615871	113073229	113073249	73525	hg19					enhancer	enh				GACAGCGGGGTCGACGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				-0.252744082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1939	chr1	113615851	113615873	113073229	113073251	73526	hg19					enhancer	enh				GCGACAGCGGGGTCGACGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.735194013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1940	chr1	113615857	113615878	113073235	113073256	73527	hg19					enhancer	enh				GCAGCGCGACAGCGGGGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.414237431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1941	chr1	113615864	113615884	113073242	113073262	73528	hg19					enhancer	enh				GCAGACGCAGCGCGACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				-0.317984877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1942	chr1	113615866	113615886	113073244	113073264	73529	hg19					enhancer	enh				GAGCAGACGCAGCGCGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.783041503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1943	chr1	113615882	113615902	113073260	113073280	73530	hg19					enhancer	enh				GCTCCTTGCATGCCTTTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	indirect	Non Significant	NA				0.005352039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1944	chr1	113615888	113615908	113073266	113073286	73531	hg19					enhancer	enh				GTACCATCTAAAGGCATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.497647869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1945	chr1	113615900	113615920	113073278	113073298	73532	hg19					enhancer	enh				GATGGTACAGCCTTCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.351010899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1946	chr1	113615913	113615934	113073291	113073312	73533	hg19					enhancer	enh				GTCTCCCGAAGCCCCGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LRIG2	direct	Highly Significant	NA				0.790783399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1947	chr1	114472239	114472259	113929617	113929637	73534	hg19					enhancer	enh				GTCGGGTCTGGCGACAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-1.786514106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1948	chr1	114472244	114472265	113929622	113929643	73535	hg19					enhancer	enh				GTCTGGCGACAACGGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-0.190516407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1949	chr1	114472251	114472273	113929629	113929651	73536	hg19					enhancer	enh				GACAACGGCGGCTGCGGAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-0.630715335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1950	chr1	114472251	114472272	113929629	113929650	73537	hg19					enhancer	enh				GACAACGGCGGCTGCGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-1.165150523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1951	chr1	114472269	114472291	113929647	113929669	73538	hg19					enhancer	enh				GCAAGGGGCCCGGCGGTAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-1.440441131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1952	chr1	114472275	114472295	113929653	113929673	73539	hg19					enhancer	enh				GGCCCGGCGGTAGCCCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-0.586628734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1953	chr1	114472280	114472302	113929658	113929680	73540	hg19					enhancer	enh				GCTGCCGTCCGGGGCTACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-0.250561133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1954	chr1	114472293	114472315	113929671	113929693	73541	hg19					enhancer	enh				GCCTCGGCCTCCTGCTGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HIPK1	indirect	Non Significant	NA				-0.126417237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1955	chr1	117909905	117909925	117367283	117367303	73542	hg19					enhancer	enh				GGCGCCGGGGTTCACTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.361888435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1956	chr1	117909911	117909931	117367289	117367309	73543	hg19					enhancer	enh				GGGGTTCACTGAACCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.081975386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1957	chr1	117910014	117910035	117367392	117367413	73544	hg19					enhancer	enh				GAGAAGCCCCGGCGTGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.455018422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1958	chr1	117910027	117910047	117367405	117367425	73545	hg19					enhancer	enh				GGCTTCTCAGTGGCCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.144078729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1959	chr1	117910028	117910050	117367406	117367428	73546	hg19					enhancer	enh				GCTTCTCAGTGGCCGCCGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.644996695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1960	chr1	117910043	117910065	117367421	117367443	73547	hg19					enhancer	enh				GGAGCGGAACTTCCTCCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.095755281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1961	chr1	117910043	117910064	117367421	117367442	73548	hg19					enhancer	enh				GAGCGGAACTTCCTCCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.175767344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1962	chr1	117910066	117910086	117367444	117367464	73549	hg19					enhancer	enh				GCTACCGCACGGGTCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.00577877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1963	chr1	117910071	117910091	117367449	117367469	73550	hg19					enhancer	enh				GACCCGTGCGGTAGCAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-1.398655386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1964	chr1	117910076	117910098	117367454	117367476	73551	hg19					enhancer	enh				GCCGCCGCTGTTGCTACCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.0961143									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1965	chr1	117910077	117910098	117367455	117367476	73552	hg19					enhancer	enh				GCCGCCGCTGTTGCTACCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				0.178125749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1966	chr1	117910116	117910136	117367494	117367514	73553	hg19					enhancer	enh				GCGTCCGAAACACCTGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.610847494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1967	chr1	117910140	117910162	117367518	117367540	73554	hg19					enhancer	enh				GCCCTTCGCGCCAGCCGTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.062148253									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1968	chr1	117910145	117910167	117367523	117367545	73555	hg19					enhancer	enh				GCCCACTCGACGGCTGGCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.120098908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1969	chr1	117910153	117910173	117367531	117367551	73556	hg19					enhancer	enh				GCTGCTGCCCACTCGACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	direct	Highly Significant	NA				0.209181934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1970	chr1	117910163	117910183	117367541	117367561	73557	hg19					enhancer	enh				GGGCAGCAGCGGGACTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.015876388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1971	chr1	117910171	117910191	117367549	117367569	73558	hg19					enhancer	enh				GCGGGACTCAGCCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	indirect	Non Significant	NA				-0.43032134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1972	chr1	117910243	117910263	117367621	117367641	73559	hg19					enhancer	enh				GCGGCGCTGGGCGAAGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	direct	Highly Significant	NA				0.912946182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1973	chr1	117910255	117910275	117367633	117367653	73560	hg19					enhancer	enh				GAAGCCGAAGCAGCGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAN1A2	direct	Highly Significant	NA				0.357121256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1974	chr1	144994826	144994848	148889636	148889658	73561	hg19					enhancer	enh				GCTGCTGAGGCTGCGGACCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.370548994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1975	chr1	144994847	144994868	148889616	148889637	73562	hg19					enhancer	enh				GAGGCTGGGGCTACGGCGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.477452629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1976	chr1	144994874	144994894	148889590	148889610	73563	hg19					enhancer	enh				GGAGAGAGCTCCAGCAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.056157983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1977	chr1	144994879	144994901	148889583	148889605	73564	hg19					enhancer	enh				GCTGGAGCTCTCTCCGGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.491191491									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1978	chr1	144994885	144994906	148889578	148889599	73565	hg19					enhancer	enh				GCTCTCTCCGGGACTCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.548132241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1979	chr1	144994895	144994915	148889569	148889589	73566	hg19					enhancer	enh				GTGAGCCCAGTCCCGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				0.173350819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1980	chr1	144994907	144994927	148889557	148889577	73567	hg19					enhancer	enh				GGGCTCACTGCTCTGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	direct	Highly Significant	NA				0.259306982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1981	chr1	144994957	144994979	148889505	148889527	73568	hg19					enhancer	enh				GGATTCCGCAAATATCTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.624413044									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1982	chr1	144994957	144994978	148889506	148889527	73569	hg19					enhancer	enh				GATTCCGCAAATATCTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.342008857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1983	chr1	144994994	144995016	148889468	148889490	73570	hg19					enhancer	enh				GCTGCGTGAACTCAGACACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				0.104612555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1984	chr1	144995017	144995038	148889446	148889467	73571	hg19					enhancer	enh				GGTGTAACCCGACTCCAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.134310161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1985	chr1	144995018	144995038	148889446	148889466	73572	hg19					enhancer	enh				GTGTAACCCGACTCCAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				0.153597178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1986	chr1	144995027	144995048	148889436	148889457	73573	hg19					enhancer	enh				GCAGAGTCCTGGCTTGGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	direct	Highly Significant	NA				1.123658397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1987	chr1	144995028	144995048	148889436	148889456	73574	hg19					enhancer	enh				GCAGAGTCCTGGCTTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				0.022763627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1988	chr1	144995034	144995055	148889429	148889450	73575	hg19					enhancer	enh				GGTGACAGCAGAGTCCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.129932308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1989	chr1	144995034	144995054	148889430	148889450	73576	hg19					enhancer	enh				GTGACAGCAGAGTCCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.363409019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1990	chr1	144995039	144995059	148889425	148889445	73577	hg19					enhancer	enh				GGACTCTGCTGTCACCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.148880871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1991	chr1	144995039	144995059	148889425	148889445	73578	hg19					enhancer	enh				GGAGGGTGACAGCAGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	direct	Highly Significant	NA				0.677017513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1992	chr1	144995049	144995070	148889414	148889435	73579	hg19					enhancer	enh				GTCACCCTCCTGGAGCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				-0.302353055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1993	chr1	144995077	144995099	148889385	148889407	73580	hg19					enhancer	enh				GAAGCTGTTAACTGCCTACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDE4DIP	indirect	Non Significant	NA				0.069026868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1994	chr1	145413095	145413116	146021896	146021917	73581	hg19					enhancer	enh				GTTAGAGGATTAGAAAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.46497916									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1995	chr1	145413155	145413175	146021837	146021857	73582	hg19					enhancer	enh				GTCCAAAATTCCAGGAACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.109809627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1996	chr1	145413219	145413239	146021773	146021793	73583	hg19					enhancer	enh				GAGTACTGGACAGCTGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.072821124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1997	chr1	145413233	145413254	146021758	146021779	73584	hg19					enhancer	enh				GTATATGGCTGGCCAGAGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-1.681671196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1998	chr1	145413269	145413290	146021722	146021743	73585	hg19					enhancer	enh				GGAACCAGAGAAGGTTTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.384924754									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit1999	chr1	145413269	145413291	146021721	146021743	73586	hg19					enhancer	enh				GGGAACCAGAGAAGGTTTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.03555404									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2000	chr1	145413269	145413289	146021723	146021743	73587	hg19					enhancer	enh				GAACCAGAGAAGGTTTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-1.130073363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2001	chr1	145413291	145413312	146021700	146021721	73588	hg19					enhancer	enh				GCTGCTGTCTCACTGAGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.302289128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2002	chr1	145413291	145413313	146021699	146021721	73589	hg19					enhancer	enh				GGCTGCTGTCTCACTGAGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.158800092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2003	chr1	145413292	145413312	146021700	146021720	73590	hg19					enhancer	enh				GACCTCAGTGAGACAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.115174056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2004	chr1	145413297	145413317	146021695	146021715	73591	hg19					enhancer	enh				GGCCGGCTGCTGTCTCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.000725989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2005	chr1	145413299	145413319	146021693	146021713	73592	hg19					enhancer	enh				GTGAGACAGCAGCCGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.33882127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2006	chr1	145413303	145413325	146021687	146021709	73593	hg19					enhancer	enh				GACAGCAGCCGGCCTGGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.442972081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2007	chr1	145413307	145413328	146021684	146021705	73594	hg19					enhancer	enh				GCAGCCGGCCTGGGGACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	direct	Highly Significant	NA				0.466983251									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2008	chr1	145413307	145413327	146021685	146021705	73595	hg19					enhancer	enh				GCAGCCGGCCTGGGGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	direct	Highly Significant	NA				0.477433948									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2009	chr1	145413350	145413372	146021640	146021662	73596	hg19					enhancer	enh				GCTGGAGCTGACCCACAGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.000147686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2010	chr1	145413350	145413371	146021641	146021662	73597	hg19					enhancer	enh				GCTGGAGCTGACCCACAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.158928655									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2011	chr1	145413359	145413380	146021632	146021653	73598	hg19					enhancer	enh				GACCCACAGAGTAGGGAATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				0.080786603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2012	chr1	145413372	145413392	146021620	146021640	73599	hg19					enhancer	enh				GGGAATCATGGCTGGAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	direct	Highly Significant	NA				0.438286505									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2013	chr1	145413398	145413418	146021594	146021614	73600	hg19					enhancer	enh				GCAGAGTAATGTTTGACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HFE2	indirect	Non Significant	NA				-0.144727448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2014	chr1	145589328	145589350	145845717	145845739	73601	hg19					enhancer	enh				GAGCCCTGGTCCGGCTCCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-1.566604009									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2015	chr1	145589334	145589354	145845713	145845733	73602	hg19					enhancer	enh				GCCTCCTGGGAGCCGGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.290056684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2016	chr1	145589341	145589361	145845706	145845726	73603	hg19					enhancer	enh				GTGTGTGGCCTCCTGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	direct	Highly Significant	NA				0.508914966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2017	chr1	145589348	145589370	145845697	145845719	73604	hg19					enhancer	enh				GCACGGAGTGTGTGTGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.001085204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2018	chr1	145589370	145589392	145845675	145845697	73605	hg19					enhancer	enh				GAAGCTCACCGACTCCGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.20403593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2019	chr1	145589373	145589393	145845674	145845694	73606	hg19					enhancer	enh				GCTCACCGACTCCGGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.300485872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2020	chr1	145589387	145589407	145845660	145845680	73607	hg19					enhancer	enh				GCTGCTCCTGTCCCGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.184093366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2021	chr1	145589394	145589414	145845653	145845673	73608	hg19					enhancer	enh				GGGTGCAGCTGCTCCTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.149366012									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2022	chr1	145589394	145589416	145845651	145845673	73609	hg19					enhancer	enh				GCGGGTGCAGCTGCTCCTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.192254785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2023	chr1	145589399	145589420	145845647	145845668	73610	hg19					enhancer	enh				GGAGCAGCTGCACCCGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.010298762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2024	chr1	145589400	145589420	145845647	145845667	73611	hg19					enhancer	enh				GAGCAGCTGCACCCGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	direct	Highly Significant	NA				0.434154753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2025	chr1	145589415	145589435	145845632	145845652	73612	hg19					enhancer	enh				GTCGCGTTATGGCCGAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	direct	Highly Significant	NA				0.64101392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2026	chr1	145589415	145589437	145845630	145845652	73613	hg19					enhancer	enh				GAGTCGCGTTATGGCCGAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	direct	Highly Significant	NA				0.495569731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2027	chr1	145589449	145589470	145845597	145845618	73614	hg19					enhancer	enh				GGCCCGCCTGGCGCCCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.194038133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2028	chr1	145589450	145589470	145845597	145845617	73615	hg19					enhancer	enh				GCCCGCCTGGCGCCCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.028843095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2029	chr1	145589454	145589474	145845593	145845613	73616	hg19					enhancer	enh				GCCACCAGAGGGCGCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				0.119179987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2030	chr1	145589455	145589475	145845592	145845612	73617	hg19					enhancer	enh				GGCCACCAGAGGGCGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.415151448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2031	chr1	145589466	145589487	145845580	145845601	73618	hg19					enhancer	enh				GAAGCTTCTCTAGGCCACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	indirect	Non Significant	NA				-0.926945575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2032	chr1	145589503	145589523	145845544	145845564	73619	hg19					enhancer	enh				GAAACCCCGCTACGACCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NUDT17	direct	Highly Significant	NA				0.667367875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-9925	chr1	147400404	147400425	147928291	147928312	73620	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCGCGGAAGCCCCAGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.059354845	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400404	147400425	147928291	147928312	73621	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCGCGGAAGCCCCAGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.059354845	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400404	147400425	147928291	147928312	73622	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCGCGGAAGCCCCAGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.059354845	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400410	147400431	147928297	147928318	73623	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCTTCCGCCGCGGAAGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.299341795	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400410	147400431	147928297	147928318	73624	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCTTCCGCCGCGGAAGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.299341795	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400410	147400431	147928297	147928318	73625	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCTTCCGCCGCGGAAGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.299341795	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400421	147400442	147928308	147928329	73626	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGGACGCTAGGCTTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.036117158	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400421	147400442	147928308	147928329	73627	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGGACGCTAGGCTTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.036117158	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400421	147400442	147928308	147928329	73628	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGGACGCTAGGCTTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.036117158	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400477	147400497	147928364	147928384	73629	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTAGCCGCTGATTGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.635451466	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400477	147400497	147928364	147928384	73630	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTAGCCGCTGATTGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.635451466	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400477	147400497	147928364	147928384	73631	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTAGCCGCTGATTGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.635451466	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400484	147400505	147928371	147928392	73632	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGCCCCAGTCAGCCAATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.109099933	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400484	147400505	147928371	147928392	73633	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGCCCCAGTCAGCCAATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.109099933	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400484	147400505	147928371	147928392	73634	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGCCCCAGTCAGCCAATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.109099933	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400519	147928385	147928406	73635	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.46459754	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400519	147928385	147928406	73636	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.46459754	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400519	147928385	147928406	73637	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.46459754	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400518	147928385	147928405	73638	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.027748223	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400518	147928385	147928405	73639	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.027748223	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400498	147400518	147928385	147928405	73640	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGGCGCAGCTTGACGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.027748223	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400499	147400519	147928386	147928406	73641	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.115076467	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400499	147400519	147928386	147928406	73642	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.115076467	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400499	147400519	147928386	147928406	73643	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGGCGCAGCTTGACGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.115076467	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400503	147400523	147928390	147928410	73644	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCAGCTTGACGGCGTCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.185383174	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400503	147400523	147928390	147928410	73645	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCAGCTTGACGGCGTCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.185383174	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400503	147400523	147928390	147928410	73646	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCAGCTTGACGGCGTCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.185383174	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400585	147400607	147928472	147928494	73647	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCCCAGCGTGCTGTGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.281822823	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400585	147400607	147928472	147928494	73648	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCCCAGCGTGCTGTGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.281822823	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400585	147400607	147928472	147928494	73649	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCCCAGCGTGCTGTGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.281822823	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400591	147400613	147928478	147928500	73650	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.434948839	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400591	147400613	147928478	147928500	73651	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.434948839	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400591	147400613	147928478	147928500	73652	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCGTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.434948839	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400593	147400613	147928480	147928500	73653	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.070747002	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400593	147400613	147928480	147928500	73654	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.070747002	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400593	147400613	147928480	147928500	73655	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GTGCTGTGGCCTCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				0.070747002	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400605	147400626	147928492	147928513	73656	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCTCCACTTCCCACTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	direct	Highly Significant	NA				0.391113505	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400605	147400626	147928492	147928513	73657	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCTCCACTTCCCACTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	direct	Highly Significant	NA				0.391113505	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400605	147400626	147928492	147928513	73658	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GCCTCCACTTCCCACTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	direct	Highly Significant	NA				0.391113505	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400650	147400670	147928537	147928557	73659	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGAGTCGATCAGGAAACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.365941105	NBPF11	chr1	148102046	148152322	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400650	147400670	147928537	147928557	73660	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGAGTCGATCAGGAAACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.365941105	GPR89B	chr1	147928419	147993592	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-9925	chr1	147400650	147400670	147928537	147928557	73661	hg19	N/A	N/A	N/A	"Enhatls11015,Enhatls11018,Enhatls11019,Enhatls11022,Enhatls11024,Enhatls11025,Enhatls10836,Enhatls11026,Enhatls10837,Enhatls10838,Enhatls11027,Enhatls11028,Enhatls10839,Enhatls11029,Enhatls11030,Enhatls10840,Enhatls11031,Enhatls10841,Enhatls10842,Enhatls11032,Enhatls10843,Enhatls10844,Enhatls11037,Enhatls11039,Enhatls10848,Enhatls11040,Enhatls11041,Enhatls11042,Enhatls11043,Enhatls11044,Enhatls11045,Enhatls11046,Enhatls11048,Enhatls11049,Enhatls11050,Enhatls10859,Enhatls11051,Enhatls10860,Enhatls10861,Enhatls11052,Enhatls10862,Enhatls11053,Enhatls11054,Enhatls11055,Enhatls11056,Enhatls11058,Enhatls10868,Enhatls10871,Enhatls10872,Enhatls10873,Enhatls11062,Enhatls11063,Enhatls11064,Enhatls11016,Enhatls11017,Enhatls11020,Enhatls11021,Enhatls11033,Enhatls11034,Enhatls11035,Enhatls11036,Enhatls11038,Enhatls11057,Enhatls10867,Enhatls10869,Enhatls11059,Enhatls11060,Enhatls10870,Enhatls10874,Enhatls10875,Enhatls11061,Enhatls10876,Enhatls11023,Enhatls11047,Enhatls11065,Enhatls10656,Enhatls11014"	enhancer	enh				GGAGTCGATCAGGAAACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPR89B	indirect	Non Significant	NA				-0.365941105	GJA8	chr1	147902794	147909269	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9924
enhrx-lit2033	chr1	148555921	148555941	144461711	144461731	73662	hg19					enhancer	enh				GCGAACCCGCTGTGCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				-0.017960602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2034	chr1	148555929	148555949	144461703	144461723	73663	hg19					enhancer	enh				GGCCGCCTCTGCGGCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	direct	Highly Significant	NA				0.451528714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2035	chr1	148555978	148556000	144461652	144461674	73664	hg19					enhancer	enh				GCCTTGGGCTCTCCTGACGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	direct	Highly Significant	NA				0.769074038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2036	chr1	148555983	148556004	144461648	144461669	73665	hg19					enhancer	enh				GGGCTCTCCTGACGCGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	direct	Highly Significant	NA				0.450965664									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2037	chr1	148555984	148556004	144461648	144461668	73666	hg19					enhancer	enh				GGCTCTCCTGACGCGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				-0.06828535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2038	chr1	148555985	148556005	144461647	144461667	73667	hg19					enhancer	enh				GCTCTCCTGACGCGCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				0.003631536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2039	chr1	148555993	148556014	144461638	144461659	73668	hg19					enhancer	enh				GACGCGCCGGGCGGGACCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				-1.113842897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2040	chr1	148556002	148556024	144461628	144461650	73669	hg19					enhancer	enh				GCTGGCTCCTCAGGGTCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				0.167358022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2041	chr1	148556053	148556074	144461578	144461599	73670	hg19					enhancer	enh				GAGACAGCGGCGGTATCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				-0.275175486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2042	chr1	148556055	148556075	144461577	144461597	73671	hg19					enhancer	enh				GACAGCGGCGGTATCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	direct	Highly Significant	NA				0.387124037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2043	chr1	148556171	148556191	144461461	144461481	73672	hg19					enhancer	enh				GGCATCCGTGCGCCACGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NBPF15	indirect	Non Significant	NA				-0.1948251									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2044	chr1	151138545	151138566	151166069	151166090	73673	hg19					enhancer	enh				GCTGTCCCGCTCTTGCTACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	direct	Highly Significant	NA				0.252565713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2045	chr1	151138553	151138574	151166077	151166098	73674	hg19					enhancer	enh				GCTCTTGCTACGGTGGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				0.074897001									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2046	chr1	151138559	151138579	151166083	151166103	73675	hg19					enhancer	enh				GCTACGGTGGCCTGGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				-1.279185663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2047	chr1	151138567	151138588	151166091	151166112	73676	hg19					enhancer	enh				GGCCTGGAGGAGTGGCGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				-0.295379603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2048	chr1	151138568	151138588	151166092	151166112	73677	hg19					enhancer	enh				GCCTGGAGGAGTGGCGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				-0.470277198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2049	chr1	151138572	151138594	151166096	151166118	73678	hg19					enhancer	enh				GTTCCGGTTTCGCCACTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	direct	Highly Significant	NA				0.32045995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2050	chr1	151138625	151138645	151166149	151166169	73679	hg19					enhancer	enh				GTGATGTCTTTCAAGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				0.058134877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2051	chr1	151138670	151138690	151166194	151166214	73680	hg19					enhancer	enh				GTGCTCAAAGTAAGCGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				0.018765661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2052	chr1	151138679	151138701	151166203	151166225	73681	hg19					enhancer	enh				GTAAGCGTGAGCGGAGAGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	indirect	Non Significant	NA				-0.349035215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2053	chr1	151138705	151138726	151166229	151166250	73682	hg19					enhancer	enh				GCCGCTTCAGTCGCTCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	direct	Highly Significant	NA				0.362629279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2054	chr1	151138708	151138730	151166232	151166254	73683	hg19					enhancer	enh				GCTTCAGTCGCTCCCTGAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	direct	Highly Significant	NA				0.684768678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2055	chr1	151138714	151138735	151166238	151166259	73684	hg19					enhancer	enh				GTCGCTCCCTGAAGGTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCNM1	direct	Highly Significant	NA				0.258922276									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2056	chr1	151162493	151162514	151190017	151190038	73685	hg19					enhancer	enh				GTTCTACCAGACGACTTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-1.238224931									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2057	chr1	151162539	151162560	151190063	151190084	73686	hg19					enhancer	enh				GCCCAGAAAGCCGGTTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.503819418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2058	chr1	151162548	151162570	151190072	151190094	73687	hg19					enhancer	enh				GCCGGTTCCCAGCGGTCTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.636549338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2059	chr1	151162559	151162581	151190083	151190105	73688	hg19					enhancer	enh				GCCGGGCACCCCGGAAGACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.164004185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2060	chr1	151162586	151162607	151190110	151190131	73689	hg19					enhancer	enh				GGTAGGCGGTATGAGTTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				0.14144225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2061	chr1	151162586	151162606	151190110	151190130	73690	hg19					enhancer	enh				GTAGGCGGTATGAGTTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	direct	Highly Significant	NA				0.937855817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2062	chr1	151162601	151162621	151190125	151190145	73691	hg19					enhancer	enh				GGCGGCGCAGTCTCGGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-2.376286547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2063	chr1	151162604	151162624	151190128	151190148	73692	hg19					enhancer	enh				GGTGGCGGCGCAGTCTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-2.62123719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2064	chr1	151162633	151162655	151190157	151190179	73693	hg19					enhancer	enh				GCTCCCAAAACCGAGCTGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	direct	Highly Significant	NA				0.338591231									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2065	chr1	151162634	151162655	151190158	151190179	73694	hg19					enhancer	enh				GCTCCCAAAACCGAGCTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.359140363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2066	chr1	151162639	151162660	151190163	151190184	73695	hg19					enhancer	enh				GTCGAGCTCCCAAAACCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.550387809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2067	chr1	151162657	151162679	151190181	151190203	73696	hg19					enhancer	enh				GACGCTCGACATCACTACCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-1.014537657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2068	chr1	151162657	151162678	151190181	151190202	73697	hg19					enhancer	enh				GACGCTCGACATCACTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-1.164452617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2069	chr1	151162660	151162682	151190184	151190206	73698	hg19					enhancer	enh				GCTCGACATCACTACCTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	direct	Highly Significant	NA				0.202283473									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2070	chr1	151162681	151162703	151190205	151190227	73699	hg19					enhancer	enh				GTGGCCACCAGCGGCGGAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.09167422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2071	chr1	151162683	151162703	151190207	151190227	73700	hg19					enhancer	enh				GGCCACCAGCGGCGGAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.687125726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2072	chr1	151162691	151162713	151190215	151190237	73701	hg19					enhancer	enh				GTAAACGCCCGACTTCCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.17397772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2073	chr1	151162792	151162812	151190316	151190336	73702	hg19					enhancer	enh				GCGGCCTAGAGCATCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VPS72	indirect	Non Significant	NA				-0.405144024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2074	chr1	151227178	151227199	151254702	151254723	73703	hg19					enhancer	enh				GGTGAAGAGCGACGGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-0.568034863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2075	chr1	151227179	151227199	151254703	151254723	73704	hg19					enhancer	enh				GTGAAGAGCGACGGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	direct	Highly Significant	NA				0.21154087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2076	chr1	151227197	151227219	151254721	151254743	73705	hg19					enhancer	enh				GCCTAACAACAACTCCTCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-0.076125934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2077	chr1	151227203	151227224	151254727	151254748	73706	hg19					enhancer	enh				GGAGTTGTTGTTAGGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-0.564729327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2078	chr1	151227204	151227224	151254728	151254748	73707	hg19					enhancer	enh				GAGTTGTTGTTAGGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-0.695460578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2079	chr1	151227212	151227232	151254736	151254756	73708	hg19					enhancer	enh				GTTAGGCCGTCCCGGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-1.746185297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2080	chr1	151227216	151227236	151254740	151254760	73709	hg19					enhancer	enh				GGCCGTCCCGGAGACCCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-2.290617879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2081	chr1	151227220	151227241	151254744	151254765	73710	hg19					enhancer	enh				GTCCCGGAGACCCGGTCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-4.222873204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2082	chr1	151227233	151227255	151254757	151254779	73711	hg19					enhancer	enh				GCCACCTTCCTCCCTCCCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-1.302015006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2083	chr1	151227234	151227255	151254758	151254779	73712	hg19					enhancer	enh				GCCACCTTCCTCCCTCCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-1.579574855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-10301	chr1	151227260	151227282	151254784	151254806	73713	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GGTGTTGGAAAGCACTATGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-2.83812821	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227261	151227282	151254785	151254806	73714	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GTGTTGGAAAGCACTATGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-2.823619537	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227266	151227287	151254790	151254811	73715	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GGAAAGCACTATGGTGTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-3.287447215	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227267	151227287	151254791	151254811	73716	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GAAAGCACTATGGTGTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-2.473308628	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227284	151227304	151254808	151254828	73717	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GTGAGGAGCTACTTCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-1.458802639	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227289	151227309	151254813	151254833	73718	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GAGCTACTTCGGGGCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				-1.680101578	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227321	151227343	151254845	151254867	73719	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GTTCCGGGCGCGTGTAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	indirect	Non Significant	NA				0.037516236	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-10301	chr1	151227327	151227347	151254851	151254871	73720	hg19	N/A	N/A	N/A	Enhatls11501	enhancer	enh				GCCTTGGCGCTACACGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSMD4	direct	Highly Significant	NA				0.274408103	PSMD4	chr1	151254708	151267479	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10300
enhrx-lit2084	chr1	151881837	151881858	151909361	151909382	73721	hg19					enhancer	enh				GAAGCGAGCCGCGACCCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.64932899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2085	chr1	151881875	151881895	151909399	151909419	73722	hg19					enhancer	enh				GCTCTGTGCCTGCCGCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.190275885									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2086	chr1	151881897	151881919	151909421	151909443	73723	hg19					enhancer	enh				GCCGCGCGCCTCCGCACGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.332365885									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2087	chr1	151881912	151881933	151909436	151909457	73724	hg19					enhancer	enh				GCGCGGCGCAGCTCCTCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.332554643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2088	chr1	151881919	151881940	151909443	151909464	73725	hg19					enhancer	enh				GCAGCTCCTCAGCATGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				0.081462834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2089	chr1	151881946	151881968	151909470	151909492	73726	hg19					enhancer	enh				GGCTAGAGCAAGCGCGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.126572039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2090	chr1	151881946	151881967	151909470	151909491	73727	hg19					enhancer	enh				GCTAGAGCAAGCGCGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.794504165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2091	chr1	151881953	151881973	151909477	151909497	73728	hg19					enhancer	enh				GCGCTTGCTCTAGCCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.334681052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2092	chr1	151881954	151881974	151909478	151909498	73729	hg19					enhancer	enh				GTCCAGGGCTAGAGCAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-1.052589319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2093	chr1	151881969	151881990	151909493	151909514	73730	hg19					enhancer	enh				GGAGGTAGAGTGCGCCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				0.149336554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2094	chr1	151881969	151881989	151909493	151909513	73731	hg19					enhancer	enh				GAGGTAGAGTGCGCCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.592159196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2095	chr1	151881970	151881990	151909494	151909514	73732	hg19					enhancer	enh				GGAGGTAGAGTGCGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.858626717									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2096	chr1	151881988	151882009	151909512	151909533	73733	hg19					enhancer	enh				GCACGCGCGCTCTTGTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				0.103133007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2097	chr1	151881999	151882020	151909523	151909544	73734	hg19					enhancer	enh				GCGCGCGTGCGAGTTAACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.503893302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2098	chr1	151882001	151882022	151909525	151909546	73735	hg19					enhancer	enh				GCGCGTGCGAGTTAACCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.08916645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2099	chr1	151882001	151882021	151909525	151909545	73736	hg19					enhancer	enh				GCGCGTGCGAGTTAACCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.217389449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2100	chr1	151882005	151882025	151909529	151909549	73737	hg19					enhancer	enh				GTGCGAGTTAACCCCTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.072147568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2101	chr1	151882011	151882032	151909535	151909556	73738	hg19					enhancer	enh				GTTAACCCCTGGGGTGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.413283726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2102	chr1	151882047	151882067	151909571	151909591	73739	hg19					enhancer	enh				GAGGAGGCGGTGCGCACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	direct	Highly Significant	NA				0.241372686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2103	chr1	151882053	151882074	151909577	151909598	73740	hg19					enhancer	enh				GCGGTGCGCACTACTGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	THEM4	indirect	Non Significant	NA				-0.173123406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2104	chr1	153599825	153599845	153627349	153627369	73741	hg19					enhancer	enh				GATCGAGCAACAGCGCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				0.185867705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2105	chr1	153599934	153599954	153627458	153627478	73742	hg19					enhancer	enh				GTCTCATGGCTGACCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				0.144169861									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2106	chr1	153599938	153599959	153627462	153627483	73743	hg19					enhancer	enh				GGGTCAGCCATGAGACTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	direct	Highly Significant	NA				0.303998688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2107	chr1	153599939	153599959	153627463	153627483	73744	hg19					enhancer	enh				GGTCAGCCATGAGACTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.234284628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2108	chr1	153599944	153599964	153627468	153627488	73745	hg19					enhancer	enh				GCCATGAGACTCACCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				0.107570899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2109	chr1	153599949	153599971	153627473	153627495	73746	hg19					enhancer	enh				GAGACTCACCCGGCAAGGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				0.007930781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2110	chr1	153599951	153599971	153627475	153627495	73747	hg19					enhancer	enh				GACTCACCCGGCAAGGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	direct	Highly Significant	NA				0.379389821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2111	chr1	153599973	153599995	153627497	153627519	73748	hg19					enhancer	enh				GGTAGAGTGAGCTGGAGCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				0.177413419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2112	chr1	153599974	153599995	153627498	153627519	73749	hg19					enhancer	enh				GTAGAGTGAGCTGGAGCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.095350793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2113	chr1	153599995	153600017	153627519	153627541	73750	hg19					enhancer	enh				GGGCTGAGGTTTATAAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.887540503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2114	chr1	153599996	153600017	153627520	153627541	73751	hg19					enhancer	enh				GGCTGAGGTTTATAAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	direct	Highly Significant	NA				1.273324527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2115	chr1	153599997	153600017	153627521	153627541	73752	hg19					enhancer	enh				GCTGAGGTTTATAAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.293237768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2116	chr1	153600003	153600024	153627527	153627548	73753	hg19					enhancer	enh				GTTTATAAGCAGCGGGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-1.294568013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2117	chr1	153600028	153600049	153627552	153627573	73754	hg19					enhancer	enh				GAGAGCTGCTTCCAAGCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.158491948									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2118	chr1	153600043	153600065	153627567	153627589	73755	hg19					enhancer	enh				GCCCGGAGGTGTCAAATTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A13	indirect	Non Significant	NA				-0.281640082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2119	chr1	153600724	153600744	153628248	153628268	73756	hg19					enhancer	enh				GGAACGGGGCAAGCAAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	direct	Highly Significant	NA				0.227640596									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2120	chr1	153600800	153600822	153628324	153628346	73757	hg19					enhancer	enh				GCTCCTGGCCCCTTGCCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.077899846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2121	chr1	153600811	153600833	153628335	153628357	73758	hg19					enhancer	enh				GACGAACACCCTGTGGGGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				0.105865825									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2122	chr1	153600823	153600843	153628347	153628367	73759	hg19					enhancer	enh				GGTGTTCGTCTGTGAAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				0.120271417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2123	chr1	153600866	153600886	153628390	153628410	73760	hg19					enhancer	enh				GGGGAGGGACTGTTGAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.316425048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2124	chr1	153600914	153600934	153628438	153628458	73761	hg19					enhancer	enh				GATGGCCAAGGTTGCAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.115309029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2125	chr1	153600926	153600948	153628450	153628472	73762	hg19					enhancer	enh				GCAGGTTCTGGACAGATGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	direct	Highly Significant	NA				0.572058446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2126	chr1	153600932	153600952	153628456	153628476	73763	hg19					enhancer	enh				GGGAGCAGGTTCTGGACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.092514374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2127	chr1	153600932	153600954	153628456	153628478	73764	hg19					enhancer	enh				GTGGGAGCAGGTTCTGGACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	direct	Highly Significant	NA				0.470908651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2128	chr1	153600952	153600972	153628476	153628496	73765	hg19					enhancer	enh				GGTTGGCCTGGGCCTGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.275377391									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2129	chr1	153600964	153600986	153628488	153628510	73766	hg19					enhancer	enh				GGCAGGGTACTCACGGTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.009135793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2130	chr1	153600964	153600985	153628488	153628509	73767	hg19					enhancer	enh				GCAGGGTACTCACGGTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	direct	Highly Significant	NA				0.297912319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2131	chr1	153600969	153600990	153628493	153628514	73768	hg19					enhancer	enh				GTGGGGCAGGGTACTCACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	direct	Highly Significant	NA				0.668934166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2132	chr1	153600973	153600995	153628497	153628519	73769	hg19					enhancer	enh				GCCCAGTGGGGCAGGGTACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.154005486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2133	chr1	153600988	153601010	153628512	153628534	73770	hg19					enhancer	enh				GCAGGCCAGGGACTAGCCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.182374647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2134	chr1	153601027	153601047	153628551	153628571	73771	hg19					enhancer	enh				GTCTTCAGAAGGGCTCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.531107949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2135	chr1	153601048	153601068	153628572	153628592	73772	hg19					enhancer	enh				GGCTGGGGACCATAGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	S100A1	indirect	Non Significant	NA				-0.078001721									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2136	chr1	153606467	153606489	153633991	153634013	73773	hg19					enhancer	enh				GTCAGATCCGCGCACGACTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	direct	Highly Significant	NA				1.136520753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2137	chr1	153606493	153606513	153634017	153634037	73774	hg19					enhancer	enh				GGCGTCTACGCAATTACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.193629372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2138	chr1	153606514	153606534	153634038	153634058	73775	hg19					enhancer	enh				GCTTGTCTGACCGGCTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.200270758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2139	chr1	153606514	153606536	153634038	153634060	73776	hg19					enhancer	enh				GTGCTTGTCTGACCGGCTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				0.111582194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2140	chr1	153606522	153606542	153634046	153634066	73777	hg19					enhancer	enh				GGTCAGACAAGCACTGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.770777435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2141	chr1	153606523	153606545	153634047	153634069	73778	hg19					enhancer	enh				GTCAGACAAGCACTGGACGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				0.137753137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2142	chr1	153606551	153606571	153634075	153634095	73779	hg19					enhancer	enh				GCTCGGTGTCCAAAACAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	direct	Highly Significant	NA				0.349540954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2143	chr1	153606575	153606597	153634099	153634121	73780	hg19					enhancer	enh				GCTGGCGGCCGCTGCAGACGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.655642427									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2144	chr1	153606579	153606601	153634103	153634125	73781	hg19					enhancer	enh				GCGGCCGCTGCAGACGAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-1.827383475									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2145	chr1	153606581	153606601	153634105	153634125	73782	hg19					enhancer	enh				GGCCGCTGCAGACGAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.948575483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2146	chr1	153606585	153606606	153634109	153634130	73783	hg19					enhancer	enh				GCTGCAGACGAAAGGCAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.780616081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2147	chr1	153606612	153606632	153634136	153634156	73784	hg19					enhancer	enh				GGCCGGGTGAGCAGACGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.127838885									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2148	chr1	153606617	153606637	153634141	153634161	73785	hg19					enhancer	enh				GGCCGATCCGTCTGCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.758742467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2149	chr1	153606684	153606705	153634208	153634229	73786	hg19					enhancer	enh				GCGGTTGGTTAGATGCGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.237722365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2150	chr1	153606707	153606727	153634231	153634251	73787	hg19					enhancer	enh				GGGGCTCGGGTTAGCTAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	direct	Highly Significant	NA				0.380798988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2151	chr1	153606731	153606751	153634255	153634275	73788	hg19					enhancer	enh				GGCCGAACCTGAGTTGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CHTOP	indirect	Non Significant	NA				-0.795734378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-10615	chr1	153700383	153700403	153727907	153727927	73789	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAGAAAAGGCCAGTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.557490855	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700395	153700415	153727919	153727939	73790	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GTAGGAAGACCTCGGCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.067545653	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700435	153700455	153727959	153727979	73791	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCCAATAGCTGCTTCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-4.297791044	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700463	153700484	153727987	153728008	73792	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAAGTGAGCAGTCGCGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-0.764322186	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700469	153700489	153727993	153728013	73793	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCGACTGCTCACTTCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	direct	Highly Significant	NA				0.223977839	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700486	153700506	153728010	153728030	73794	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAAATCGTCTAGGCCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.905830319	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700539	153700559	153728063	153728083	73795	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCGGCCATAGTGGAAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-2.150833875	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700558	153700580	153728082	153728104	73796	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GTCTCCCCACACCACACAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-3.762304661	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700593	153700615	153728117	153728139	73797	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCAATAAGCGCTATGGGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-2.742856392	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700594	153700615	153728118	153728139	73798	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCAATAAGCGCTATGGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-0.848116989	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700598	153700618	153728122	153728142	73799	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAGGCAATAAGCGCTATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-3.800672174	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700602	153700622	153728126	153728146	73800	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GGGTGAGGCAATAAGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-2.066416143	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700602	153700624	153728126	153728148	73801	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAGGGTGAGGCAATAAGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-3.008160428	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700629	153700650	153728153	153728174	73802	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCCTTTGGATCCGGCCCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.992909533	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700630	153700650	153728154	153728174	73803	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GCCTTTGGATCCGGCCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.637886971	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700639	153700660	153728163	153728184	73804	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GGAGTGCAGCGCCTTTGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-1.274701467	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-10615	chr1	153700639	153700659	153728163	153728183	73805	hg19	N/A	enh61908	N/A	N/A	enhancer	enh				GAGTGCAGCGCCTTTGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INTS3	indirect	Non Significant	NA				-2.156174366	INTS3	chr1	153728049	153774808	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10614
enhrx-lit2152	chr1	153930960	153930981	153958484	153958505	73806	hg19					enhancer	enh				GAAGGAAGATGGCGACGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-2.45494293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2153	chr1	153930994	153931016	153958518	153958540	73807	hg19					enhancer	enh				GCCACCCTCCCAGTACCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-0.169690171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2154	chr1	153931001	153931021	153958525	153958545	73808	hg19					enhancer	enh				GGCCGCGGCTGGTACTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-0.532580334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2155	chr1	153931006	153931026	153958530	153958550	73809	hg19					enhancer	enh				GCGGAGGCCGCGGCTGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-0.041924162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2156	chr1	153931065	153931087	153958589	153958611	73810	hg19					enhancer	enh				GCCTCAGCGAGCACCGCGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-0.825911428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2157	chr1	153931066	153931086	153958590	153958610	73811	hg19					enhancer	enh				GTTCGCGGTGCTCGCTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				-0.124083978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2158	chr1	153931093	153931115	153958617	153958639	73812	hg19					enhancer	enh				GCAACAGGTCAGGGCTAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				0.135811421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2159	chr1	153931095	153931115	153958619	153958639	73813	hg19					enhancer	enh				GCAACAGGTCAGGGCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				0.192123071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2160	chr1	153931100	153931120	153958624	153958644	73814	hg19					enhancer	enh				GCCCTGACCTGTTGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRTC2	indirect	Non Significant	NA				0.164309071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2161	chr1	154934151	154934173	154961675	154961697	73815	hg19					enhancer	enh				GCACTTTGTGGTTGCTGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	direct	Highly Significant	NA				0.225887009									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2162	chr1	154934158	154934180	154961682	154961704	73816	hg19					enhancer	enh				GCAACCACAAAGTGCGACGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.467293077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2163	chr1	154934158	154934179	154961682	154961703	73817	hg19					enhancer	enh				GCAACCACAAAGTGCGACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.140050965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2164	chr1	154934191	154934211	154961715	154961735	73818	hg19					enhancer	enh				GCGCAGTTTGCGCGGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	direct	Highly Significant	NA				0.553276953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2165	chr1	154934191	154934213	154961715	154961737	73819	hg19					enhancer	enh				GCGCGCAGTTTGCGCGGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				0.196860862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2166	chr1	154934196	154934217	154961720	154961741	73820	hg19					enhancer	enh				GAGAGCGCGCAGTTTGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.813743323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2167	chr1	154934199	154934220	154961723	154961744	73821	hg19					enhancer	enh				GGAGAGAGCGCGCAGTTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.856086612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2168	chr1	154934199	154934219	154961723	154961743	73822	hg19					enhancer	enh				GAGAGAGCGCGCAGTTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.400481163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2169	chr1	154934221	154934241	154961745	154961765	73823	hg19					enhancer	enh				GACTCGCCGCCCGCCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-1.283364523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2170	chr1	154934230	154934251	154961754	154961775	73824	hg19					enhancer	enh				GTTGCTGCCGCCGCTGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				0.012725704									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2171	chr1	154934237	154934257	154961761	154961781	73825	hg19					enhancer	enh				GTTCCGGTTGCTGCCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.216216338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2172	chr1	154934237	154934257	154961761	154961781	73826	hg19					enhancer	enh				GCGGCGGCAGCAACCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.328025213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2173	chr1	154934271	154934293	154961795	154961817	73827	hg19					enhancer	enh				GCCACCACCACTGAGCGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.947642187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2174	chr1	154934271	154934292	154961795	154961816	73828	hg19					enhancer	enh				GCCACCACCACTGAGCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.724063481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2175	chr1	154934316	154934336	154961840	154961860	73829	hg19					enhancer	enh				GAGACGCTACGCCTGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.566150958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2176	chr1	154934357	154934379	154961881	154961903	73830	hg19					enhancer	enh				GCTTACCACGGCACCACGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.087326957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2177	chr1	154934373	154934393	154961897	154961917	73831	hg19					enhancer	enh				GACGACCCTTTCCACTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	direct	Highly Significant	NA				0.512378174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2178	chr1	154934381	154934401	154961905	154961925	73832	hg19					enhancer	enh				GAAAGGGTCGTCTCCGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PYGO2	indirect	Non Significant	NA				-0.942189465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-10845	chr1	154947008	154947028	154974532	154974552	73833	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GTGAGAACTGCCCTCCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.440881827	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947040	154947062	154974564	154974586	73834	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GAAGTAAATCTAAGCCAATCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.558623056	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947078	154947098	154974602	154974622	73835	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GTGTCCCGCCTCGAGCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.362771492	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947085	154947107	154974609	154974631	73836	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GCCTCGAGCCAAACGGACCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.68166077	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947099	154947119	154974623	154974643	73837	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GGACCAATAGGAAGTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.732845613	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947116	154947136	154974640	154974660	73838	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GGGCGGCGTGTTTGAAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				-0.098899254	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947123	154947145	154974647	154974669	73839	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GTGTTTGAAAGCGAGGCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				-0.191096412	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947125	154947145	154974649	154974669	73840	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GTTTGAAAGCGAGGCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.201558818	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947125	154947146	154974649	154974670	73841	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GTTTGAAAGCGAGGCCAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.255344393	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947129	154947150	154974653	154974674	73842	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GAAAGCGAGGCCAAAGTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.411842038	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947266	154947288	154974790	154974812	73843	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GAGTTTGAGTATCGGTTAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				-0.463033424	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-10845	chr1	154947272	154947293	154974796	154974817	73844	hg19	N/A	N/A	N/A	Enhatls12060	enhancer	enh				GAGTATCGGTTAGTGCTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				0.040822767	CKS1B	chr1	154974652	154979251	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10844
enhrx-lit2179	chr1	154947286	154947307	154974810	154974831	73845	hg19					enhancer	enh				GCTGGCGCGGGAGCAATAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	direct	Highly Significant	NA				0.489131828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2180	chr1	154947310	154947331	154974834	154974855	73846	hg19					enhancer	enh				GTCGTGAGCTTTGGCCGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				-0.847317741									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2181	chr1	154947317	154947338	154974841	154974862	73847	hg19					enhancer	enh				GCTTTGGCCGCTGAGGGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				0.071955627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2182	chr1	154947331	154947351	154974855	154974875	73848	hg19					enhancer	enh				GGGCACAAGGAATTAGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CKS1B	indirect	Non Significant	NA				-0.640677552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2183	chr1	154955654	154955674	154983178	154983198	73849	hg19					enhancer	enh				GGTTGTCGCCTATAACAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	direct	Highly Significant	NA				0.486319538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2184	chr1	154955692	154955714	154983216	154983238	73850	hg19					enhancer	enh				GTCGCTCTCAGGCTTTAGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.432491559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2185	chr1	154955709	154955730	154983233	154983254	73851	hg19					enhancer	enh				GCGACAGTTGAATACACCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	direct	Highly Significant	NA				0.213791759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2186	chr1	154955737	154955758	154983261	154983282	73852	hg19					enhancer	enh				GCTGTCGCTTAGACTCTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				0.089809629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2187	chr1	154955784	154955806	154983308	154983330	73853	hg19					enhancer	enh				GTGCAAGGCGGGACTTTAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.028376581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2188	chr1	154955786	154955806	154983310	154983330	73854	hg19					enhancer	enh				GCAAGGCGGGACTTTAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.331203503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2189	chr1	154955807	154955827	154983331	154983351	73855	hg19					enhancer	enh				GGAAGCTGCCCCGGGACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.034269724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2190	chr1	154955811	154955832	154983335	154983356	73856	hg19					enhancer	enh				GCTGCCCCGGGACATGAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.410165652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2191	chr1	154955819	154955839	154983343	154983363	73857	hg19					enhancer	enh				GGGACATGAGGAAAGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.802423286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2192	chr1	154955834	154955856	154983358	154983380	73858	hg19					enhancer	enh				GAACAAGGGAAAGAGCCGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.656709851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2193	chr1	154955846	154955867	154983370	154983391	73859	hg19					enhancer	enh				GAGCCGGTGAAGGGGCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-1.141002165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2194	chr1	154955851	154955871	154983375	154983395	73860	hg19					enhancer	enh				GGTGAAGGGGCAGAACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-2.083329674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2195	chr1	154955885	154955907	154983409	154983431	73861	hg19					enhancer	enh				GAGGGCTCAGTAATCTGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				0.024166754									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2196	chr1	154955887	154955907	154983411	154983431	73862	hg19					enhancer	enh				GGGCTCAGTAATCTGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.282277835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2197	chr1	154955916	154955937	154983440	154983461	73863	hg19					enhancer	enh				GAAGGGATTCTGGGCTAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				0.005659905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2198	chr1	154955916	154955936	154983440	154983460	73864	hg19					enhancer	enh				GAAGGGATTCTGGGCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	direct	Highly Significant	NA				0.207939633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2199	chr1	154955985	154956005	154983509	154983529	73865	hg19					enhancer	enh				GAGAGCGAATGCATTGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FLAD1	indirect	Non Significant	NA				-0.080880684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2200	chr1	155145562	155145582	155173086	155173106	73866	hg19					enhancer	enh				GGGCATTTCCACCGGACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.636296269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2201	chr1	155145659	155145679	155173183	155173203	73867	hg19					enhancer	enh				GTCCCCAGGAAGTCCTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.772265455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2202	chr1	155145664	155145684	155173188	155173208	73868	hg19					enhancer	enh				GGACTTCCTGGGGACCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.245329559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2203	chr1	155145681	155145701	155173205	155173225	73869	hg19					enhancer	enh				GATGGGTAACAGGACCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.648623328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2204	chr1	155145683	155145705	155173207	155173229	73870	hg19					enhancer	enh				GCATGATGGGTAACAGGACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.71629635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2205	chr1	155145686	155145706	155173210	155173230	73871	hg19					enhancer	enh				GGCATGATGGGTAACAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.649476643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2206	chr1	155145691	155145711	155173215	155173235	73872	hg19					enhancer	enh				GGCGGGGCATGATGGGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-1.373100646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2207	chr1	155145699	155145719	155173223	155173243	73873	hg19					enhancer	enh				GACTCACGGGCGGGGCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.065990746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2208	chr1	155145703	155145723	155173227	155173247	73874	hg19					enhancer	enh				GCCCCGCCCGTGAGTCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.32260254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2209	chr1	155145707	155145727	155173231	155173251	73875	hg19					enhancer	enh				GCCGGTTGGACTCACGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.571725221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2210	chr1	155145708	155145729	155173232	155173253	73876	hg19					enhancer	enh				GCGCCGGTTGGACTCACGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	direct	Highly Significant	NA				0.23854045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2211	chr1	155145712	155145732	155173236	155173256	73877	hg19					enhancer	enh				GTGAGTCCAACCGGCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				0.028672257									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2212	chr1	155145725	155145746	155173249	155173270	73878	hg19					enhancer	enh				GCCTTTCTTGGCCAGAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.882495134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2213	chr1	155145733	155145755	155173257	155173279	73879	hg19					enhancer	enh				GGCCAAGAAAGGCGAGCTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				0.101189207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2214	chr1	155145734	155145755	155173258	155173279	73880	hg19					enhancer	enh				GCCAAGAAAGGCGAGCTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.35335774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2215	chr1	155145739	155145761	155173263	155173285	73881	hg19					enhancer	enh				GAAAGGCGAGCTGAACCGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.793066476									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2216	chr1	155145772	155145794	155173296	155173318	73882	hg19					enhancer	enh				GCGCATGCGTCAGCGCTTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.090367185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2217	chr1	155145774	155145794	155173298	155173318	73883	hg19					enhancer	enh				GCATGCGTCAGCGCTTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				0.13802175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2218	chr1	155145864	155145884	155173388	155173408	73884	hg19					enhancer	enh				GGGAGGAAATAATGCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRTCAP2	indirect	Non Significant	NA				-0.763323551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2219	chr1	155225149	155225171	155255358	155255380	73885	hg19					enhancer	enh				GCCGCGGCCTCTCCCCACCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				-0.74083526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2220	chr1	155225167	155225189	155255376	155255398	73886	hg19					enhancer	enh				GACACAGGAGACAGCGGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				0.114862878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2221	chr1	155225184	155225204	155255393	155255413	73887	hg19					enhancer	enh				GGGAGCGGGACAGGCGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				-0.22464424									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2222	chr1	155225227	155225247	155255436	155255456	73888	hg19					enhancer	enh				GAGCTCCGGCTGCCGCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				-0.254828942									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2223	chr1	155225229	155225249	155255438	155255458	73889	hg19					enhancer	enh				GCTCCGGCTGCCGCAGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				0.017768192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2224	chr1	155225238	155225260	155255447	155255469	73890	hg19					enhancer	enh				GCCGCAGGTCGGGGACTAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	indirect	Non Significant	NA				-0.049981367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2225	chr1	155225241	155225262	155255450	155255471	73891	hg19					enhancer	enh				GCAGGTCGGGGACTAGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM189B	direct	Highly Significant	NA				0.221709204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2226	chr1	155278476	155278496	155308685	155308705	73892	hg19					enhancer	enh				GTGACGGACGACCAATGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-1.355391128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2227	chr1	155278481	155278501	155308690	155308710	73893	hg19					enhancer	enh				GCACTGTGACGGACGACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-1.927481344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2228	chr1	155278492	155278512	155308701	155308721	73894	hg19					enhancer	enh				GGCGCACTGTGGCACTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.671383683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2229	chr1	155278503	155278525	155308712	155308734	73895	hg19					enhancer	enh				GTCGTGTGAGCATGGCGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-2.228402355									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2230	chr1	155278513	155278535	155308722	155308744	73896	hg19					enhancer	enh				GCTGCTGGCCGTCGTGTGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				0.100883801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2231	chr1	155278522	155278544	155308731	155308753	73897	hg19					enhancer	enh				GACGGCCAGCAGCCAATCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.028729395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2232	chr1	155278530	155278550	155308739	155308759	73898	hg19					enhancer	enh				GAGCCGCGCTGATTGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	direct	Highly Significant	NA				0.334934742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2233	chr1	155278543	155278564	155308752	155308773	73899	hg19					enhancer	enh				GCGGCTCATCTTCGCCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				0.137525526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2234	chr1	155278560	155278581	155308769	155308790	73900	hg19					enhancer	enh				GCGATCCTGCGTGTCCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.066137993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2235	chr1	155278565	155278587	155308774	155308796	73901	hg19					enhancer	enh				GATAACGCGATCCTGCGTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.965869319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2236	chr1	155278579	155278599	155308788	155308808	73902	hg19					enhancer	enh				GCGTTATCTGTCCCTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.415920152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2237	chr1	155278636	155278656	155308845	155308865	73903	hg19					enhancer	enh				GCCCTTAGTGTGGGGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-2.989013375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2238	chr1	155278640	155278662	155308849	155308871	73904	hg19					enhancer	enh				GTTCCCGCTCTCCCCACACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-1.704613851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2239	chr1	155278641	155278662	155308850	155308871	73905	hg19					enhancer	enh				GTTCCCGCTCTCCCCACACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-2.084550843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2240	chr1	155278714	155278734	155308923	155308943	73906	hg19					enhancer	enh				GCTCGGTCCCGCTTGTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-2.242695325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2241	chr1	155278714	155278734	155308923	155308943	73907	hg19					enhancer	enh				GCCAACAAGCGGGACCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.822100103									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2242	chr1	155278732	155278754	155308941	155308963	73908	hg19					enhancer	enh				GCAGGAATCCGTATCTGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-1.130668535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2243	chr1	155278742	155278763	155308951	155308972	73909	hg19					enhancer	enh				GTATCTGGGAACAGGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-0.900902751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2244	chr1	155278803	155278825	155309012	155309034	73910	hg19					enhancer	enh				GTATCGTTACAGAAGTAAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-1.558990089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2245	chr1	155278815	155278835	155309024	155309044	73911	hg19					enhancer	enh				GTAACGATACTGTGAGGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FDPS	indirect	Non Significant	NA				-2.196880175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2246	chr1	155294256	155294277	155324465	155324486	73912	hg19					enhancer	enh				GTGTAGCCCAGCGCACCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.066689492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2247	chr1	155294289	155294311	155324498	155324520	73913	hg19					enhancer	enh				GCCCCGTCCTCTCCCGCCCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	direct	Highly Significant	NA				0.267001354									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2248	chr1	155294304	155294326	155324513	155324535	73914	hg19					enhancer	enh				GCCCTACAGGCCCTAGCAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.197903892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2249	chr1	155294305	155294326	155324514	155324535	73915	hg19					enhancer	enh				GCCCTGCTAGGGCCTGTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.086233461									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2250	chr1	155294313	155294333	155324522	155324542	73916	hg19					enhancer	enh				GCCCTAGCAGGGCAGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				-3.336596085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2251	chr1	155294335	155294357	155324544	155324566	73917	hg19					enhancer	enh				GTGAGCGCGGCCATCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	direct	Highly Significant	NA				0.459226078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2252	chr1	155294337	155294357	155324546	155324566	73918	hg19					enhancer	enh				GAGCGCGGCCATCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.182637638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2253	chr1	155294352	155294372	155324561	155324581	73919	hg19					enhancer	enh				GATCCCGGAACTCCGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				-0.006713602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2254	chr1	155294353	155294373	155324562	155324582	73920	hg19					enhancer	enh				GGATCCCGGAACTCCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.099840657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2255	chr1	155294359	155294380	155324568	155324589	73921	hg19					enhancer	enh				GAGTTCCGGGATCCTGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				0.160066188									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2256	chr1	155294387	155294407	155324596	155324616	73922	hg19					enhancer	enh				GTGCCCTGAGGGAGGGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				-0.611945265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2257	chr1	155294393	155294413	155324602	155324622	73923	hg19					enhancer	enh				GTTCCCTGTGCCCTCCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RUSC1	indirect	Non Significant	NA				-0.991474139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2258	chr1	155658330	155658351	155688539	155688560	73924	hg19					enhancer	enh				GCTGGCTCGCAGGACGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	direct	Highly Significant	NA				0.505237917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2259	chr1	155658349	155658369	155688558	155688578	73925	hg19					enhancer	enh				GTGAGCGCGTACGGGATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.218752697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2260	chr1	155658372	155658394	155688581	155688603	73926	hg19					enhancer	enh				GAACTGGGCGAGGAGGTTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.57779437									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2261	chr1	155658404	155658425	155688613	155688634	73927	hg19					enhancer	enh				GCCGGCTTGACAGGGTCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.067107103									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2262	chr1	155658405	155658425	155688614	155688634	73928	hg19					enhancer	enh				GCCGGCTTGACAGGGTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.11918725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2263	chr1	155658413	155658433	155688622	155688642	73929	hg19					enhancer	enh				GCGCTGGAGCCGGCTTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.452305152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2264	chr1	155658423	155658443	155688632	155688652	73930	hg19					enhancer	enh				GTGAGGGCCTGCGCTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.123900411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2265	chr1	155658434	155658455	155688643	155688664	73931	hg19					enhancer	enh				GGCCCTCACGCGTACCTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.471093168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2266	chr1	155658435	155658455	155688644	155688664	73932	hg19					enhancer	enh				GCCCTCACGCGTACCTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.770628052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2267	chr1	155658439	155658459	155688648	155688668	73933	hg19					enhancer	enh				GCCGCTGAAGGTACGCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.776697856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2268	chr1	155658440	155658461	155688649	155688670	73934	hg19					enhancer	enh				GCGCCGCTGAAGGTACGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.366007761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2269	chr1	155658451	155658471	155688660	155688680	73935	hg19					enhancer	enh				GCTTGGGCTCGCGCCGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-0.341134256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2270	chr1	155658451	155658472	155688660	155688681	73936	hg19					enhancer	enh				GGCTTGGGCTCGCGCCGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				0.021941851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2271	chr1	155658640	155658662	155688849	155688871	73937	hg19					enhancer	enh				GAAGGGACCGGCAAAGCGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YY1AP1	indirect	Non Significant	NA				-2.731234986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-11051	chr1	155990532	155990552	156020741	156020761	73938	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GTAACCTTGCAAGAGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.63985972	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990539	155990560	156020748	156020769	73939	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAGGACGTGTAACCTTGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				0.182696922	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990607	155990629	156020816	156020838	73940	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GTCCGCGCATCACCCCGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				0.170652015	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990608	155990629	156020817	156020838	73941	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GTCCGCGCATCACCCCGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				0.173005286	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990644	155990666	156020853	156020875	73942	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GCTTAGGGCGTCCGAACGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-1.161739492	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990649	155990670	156020858	156020879	73943	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGAGGCTTAGGGCGTCCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.231011843	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990649	155990669	156020858	156020878	73944	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAGGCTTAGGGCGTCCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.083370335	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990650	155990670	156020859	156020879	73945	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGAGGCTTAGGGCGTCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.772784061	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990668	155990689	156020877	156020898	73946	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGATGCCAACGGTAAGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.262237095	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990668	155990690	156020877	156020899	73947	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGGATGCCAACGGTAAGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.496582427	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990668	155990688	156020877	156020897	73948	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GATGCCAACGGTAAGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.170311839	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990680	155990702	156020889	156020911	73949	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGAAAGGCGTTTGGGATGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.717491286	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990680	155990701	156020889	156020910	73950	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAAAGGCGTTTGGGATGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.831756059	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990694	155990716	156020903	156020925	73951	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GCCTTTCCGGAGCCACAAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	direct	Highly Significant	NA				0.748445933	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990723	155990744	156020932	156020953	73952	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAGCGTCAGCATCCGAAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	direct	Highly Significant	NA				0.270265651	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990737	155990757	156020946	156020966	73953	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAAAGACCGGAAATAAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				-0.469447614	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990741	155990761	156020950	156020970	73954	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GACCGGAAATAAGCACTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	direct	Highly Significant	NA				0.591085852	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990824	155990844	156021033	156021053	73955	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GGCGGGCACTACAAAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	direct	Highly Significant	NA				0.2358231	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990832	155990852	156021041	156021061	73956	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GTAGTGCCCGCCTGCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	direct	Highly Significant	NA				0.434200956	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11051	chr1	155990851	155990872	156021060	156021081	73957	hg19	N/A	N/A	N/A	Enhatls12294	enhancer	enh				GAGGCTGTGAGCGCTCCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSR2	indirect	Non Significant	NA				0.01466699	SSR2	chr1	156009047	156020951	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11050
enhrx-11079	chr1	156127382	156127403	156157591	156157612	73958	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GTGGTCAGCAGACTACACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	indirect	Non Significant	NA				-0.711161622	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127434	156127454	156157643	156157663	73959	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GATTCTCTAAGGCGTGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	indirect	Non Significant	NA				0.129851859	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127462	156127482	156157671	156157691	73960	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GGGGAAATTGTTTAACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	indirect	Non Significant	NA				-0.524035246	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127481	156127501	156157690	156157710	73961	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GTCAAACCGCACATTTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	indirect	Non Significant	NA				0.11426018	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127551	156127573	156157760	156157782	73962	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GCTACTGGCAGATACAACCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	direct	Highly Significant	NA				0.232483985	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127554	156127574	156157763	156157783	73963	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GGCTACTGGCAGATACAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	direct	Highly Significant	NA				0.314679428	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127609	156127629	156157818	156157838	73964	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GCCAAGTCTAGATTTAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	direct	Highly Significant	NA				0.37680251	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127613	156127635	156157822	156157844	73965	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GACCCAAGTTTAAATCTAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	indirect	Non Significant	NA				-0.163617405	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11079	chr1	156127684	156127704	156157893	156157913	73966	hg19	N/A	N/A	N/A	Enhatls12324	enhancer	enh				GGCTATTACTTGAATAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4A	direct	Highly Significant	NA				0.407152956	SEMA4A	chr1	156147365	156177752	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11078
enhrx-11135	chr1	156307869	156307891	156338078	156338100	73967	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GCTGGGGCAACACTGAAAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.216059046	CCT3	chr1	156308967	156367873	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307869	156307891	156338078	156338100	73968	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GCTGGGGCAACACTGAAAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.216059046	TSACC	chr1	156337313	156346995	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307892	156307912	156338101	156338121	73969	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GGACAGAAGAGGGCGAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-3.105990019	CCT3	chr1	156308967	156367873	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307892	156307912	156338101	156338121	73970	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GGACAGAAGAGGGCGAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-3.105990019	TSACC	chr1	156337313	156346995	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307920	156307940	156338129	156338149	73971	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GTTCTGGGGATGCCAGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.854216263	CCT3	chr1	156308967	156367873	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307920	156307940	156338129	156338149	73972	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GTTCTGGGGATGCCAGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.854216263	TSACC	chr1	156337313	156346995	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307936	156307957	156338145	156338166	73973	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GAACTCACTGAGCACGAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.328086925	CCT3	chr1	156308967	156367873	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-11135	chr1	156307936	156307957	156338145	156338166	73974	hg19	N/A	N/A	N/A	Enhatls12383	enhancer	enh				GAACTCACTGAGCACGAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.328086925	TSACC	chr1	156337313	156346995	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11134
enhrx-lit2272	chr1	156307953	156307974	156338162	156338183	73975	hg19					enhancer	enh				GCACTGGACGATGGCCCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.268433165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2273	chr1	156307971	156307993	156338180	156338202	73976	hg19					enhancer	enh				GCTCTGCATCGCGTCGCCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.207603309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2274	chr1	156307986	156308007	156338195	156338216	73977	hg19					enhancer	enh				GCAGAGCCGGGTACCCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.87123545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2275	chr1	156307986	156308008	156338195	156338217	73978	hg19					enhancer	enh				GCAGAGCCGGGTACCCAGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.990244565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2276	chr1	156307989	156308009	156338198	156338218	73979	hg19					enhancer	enh				GAGCCGGGTACCCAGAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.922267089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2277	chr1	156308052	156308074	156338261	156338283	73980	hg19					enhancer	enh				GCCCAGAAAACGCTGCCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				0.098373952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2278	chr1	156308070	156308092	156338279	156338301	73981	hg19					enhancer	enh				GGTTGAGGTGTAAGCCCTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-2.675771444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2279	chr1	156308070	156308091	156338279	156338300	73982	hg19					enhancer	enh				GTTGAGGTGTAAGCCCTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-2.635527536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2280	chr1	156308073	156308093	156338282	156338302	73983	hg19					enhancer	enh				GGGTTGAGGTGTAAGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.81722331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2281	chr1	156308094	156308114	156338303	156338323	73984	hg19					enhancer	enh				GGCGACTACCTTGAGAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-2.238623631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2282	chr1	156308122	156308142	156338331	156338351	73985	hg19					enhancer	enh				GCCGATCAATGAGATGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.159613716									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2283	chr1	156308156	156308176	156338365	156338385	73986	hg19					enhancer	enh				GCGGGACTAAGGCTGTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.059362795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2284	chr1	156308179	156308199	156338388	156338408	73987	hg19					enhancer	enh				GTCTGGCCGTTCTTGCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-0.411965852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2285	chr1	156308219	156308241	156338428	156338450	73988	hg19					enhancer	enh				GACGAAGGCACTGGGAGGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCT3	indirect	Non Significant	NA				-1.393507742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-11725	chr1	160457057	160457079	160487267	160487289	73989	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GAATATGTCAAAGTTCTTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	direct	Highly Significant	NA				0.465612053	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457063	160457083	160487273	160487293	73990	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GTCAAAGTTCTTCCAGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				-0.023524187	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457069	160457089	160487279	160487299	73991	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GTTCTTCCAGAGGAAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				-1.790659877	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457081	160457101	160487291	160487311	73992	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GAAGGCTGGGGAATGTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	direct	Highly Significant	NA				0.263922709	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457173	160457193	160487383	160487403	73993	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GCAACACTGCAGCAAACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	direct	Highly Significant	NA				0.38452473	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457173	160457194	160487383	160487404	73994	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GCAACACTGCAGCAAACCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				0.143419828	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457210	160457232	160487420	160487442	73995	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GAAAGGCAGCCTTGCTGTATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				-0.080745515	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457215	160457237	160487425	160487447	73996	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GCAGCCTTGCTGTATGAAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				-0.925063046	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457255	160457277	160487465	160487487	73997	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GAAGGAAAGTAGAGCTGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				-0.982751655	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457364	160457386	160487574	160487596	73998	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GCAAAAGATGGAGCAGGCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	direct	Highly Significant	NA				0.310301657	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457372	160457394	160487582	160487604	73999	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GAATTATAGCAAAAGATGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				0.036438791	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-11725	chr1	160457378	160457398	160487588	160487608	74000	hg19	N/A	N/A	N/A	Enhatls13003	enhancer	enh				GTTAGAATTATAGCAAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLAMF6	indirect	Non Significant	NA				0.175890009	SLAMF6	chr1	160485029	160523262	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11724
enhrx-lit2286	chr1	161087705	161087725	161117915	161117935	74001	hg19					enhancer	enh				GCGAAGCAGGGTACCCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-1.391691431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2287	chr1	161087780	161087800	161117990	161118010	74002	hg19					enhancer	enh				GTCGCGCCGGCAAGAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-4.128622847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2288	chr1	161087815	161087837	161118025	161118047	74003	hg19					enhancer	enh				GAAACCCAGCAGGCGGCGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-1.755198344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2289	chr1	161087820	161087841	161118030	161118051	74004	hg19					enhancer	enh				GCCGCCTGCTGGGTTTCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-0.165291506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2290	chr1	161087876	161087896	161118086	161118106	74005	hg19					enhancer	enh				GTGGGCGGTAACTCGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	direct	Highly Significant	NA				0.467167131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2291	chr1	161087880	161087902	161118090	161118112	74006	hg19					enhancer	enh				GCGAGTTACCGCCCACTCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-0.04191818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2292	chr1	161087891	161087911	161118101	161118121	74007	hg19					enhancer	enh				GAAGCGCCGCAGCGAGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-0.380003954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2293	chr1	161087984	161088006	161118194	161118216	74008	hg19					enhancer	enh				GATTCACCGCGGCCGACGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-0.657163506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2294	chr1	161088012	161088034	161118222	161118244	74009	hg19					enhancer	enh				GTTACACAAGTTAAAGCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	direct	Highly Significant	NA				0.333934446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2295	chr1	161088027	161088048	161118237	161118258	74010	hg19					enhancer	enh				GTGTAACAGAGATGCTGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	direct	Highly Significant	NA				0.337451145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2296	chr1	161088065	161088085	161118275	161118295	74011	hg19					enhancer	enh				GACGGGCCAACTGGAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIT1	indirect	Non Significant	NA				-1.910335912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2297	chr1	161494139	161494159	161524349	161524369	74012	hg19					enhancer	enh				GAGAAGGTTCGGGCAGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	direct	Highly Significant	NA				0.617092099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2298	chr1	161494179	161494199	161524389	161524409	74013	hg19					enhancer	enh				GCTGACTCAGCCGGGTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				0.161462938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2299	chr1	161494184	161494205	161524394	161524415	74014	hg19					enhancer	enh				GCCCGGGCTGACTCAGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				-0.42907909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2300	chr1	161494202	161494223	161524412	161524433	74015	hg19					enhancer	enh				GTTGAGAGCCTCTCGCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				0.198348075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2301	chr1	161494207	161494227	161524417	161524437	74016	hg19					enhancer	enh				GCGAGAGGCTCTCAACTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				-0.554755101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2302	chr1	161494254	161494275	161524464	161524485	74017	hg19					enhancer	enh				GTTCGCGAAAGTTCGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				-0.018670978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2303	chr1	161494341	161494362	161524551	161524572	74018	hg19					enhancer	enh				GGCTGGCTGCAGAGAAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				-0.195128346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2304	chr1	161494342	161494363	161524552	161524573	74019	hg19					enhancer	enh				GCTGGCTGCAGAGAAACCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	direct	Highly Significant	NA				0.457391224									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2305	chr1	161494342	161494362	161524552	161524572	74020	hg19					enhancer	enh				GCTGGCTGCAGAGAAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPA6	indirect	Non Significant	NA				0.001006644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2306	chr1	162348093	162348113	162378303	162378323	74021	hg19					enhancer	enh				GCTATCTGGGAGGAACACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-0.16502757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2307	chr1	162348103	162348125	162378313	162378335	74022	hg19					enhancer	enh				GTTCCAAACCAGGCTATCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-0.085396224									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2308	chr1	162348202	162348222	162378412	162378432	74023	hg19					enhancer	enh				GAGCTTTCTCTACACCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	direct	Highly Significant	NA				0.435934724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2309	chr1	162348207	162348229	162378417	162378439	74024	hg19					enhancer	enh				GTGTAGAGAAAGCTCATGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-0.299917804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2310	chr1	162348209	162348229	162378419	162378439	74025	hg19					enhancer	enh				GTAGAGAAAGCTCATGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	direct	Highly Significant	NA				0.639441737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2311	chr1	162348278	162348299	162378488	162378509	74026	hg19					enhancer	enh				GAGATTTGCCCAATATCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-0.565410096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2312	chr1	162348327	162348347	162378537	162378557	74027	hg19					enhancer	enh				GTTTAGACTCTAAACTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-2.012555007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2313	chr1	162348409	162348429	162378619	162378639	74028	hg19					enhancer	enh				GTGATGCACACAGGACCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	direct	Highly Significant	NA				0.535771875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2314	chr1	162348414	162348435	162378624	162378645	74029	hg19					enhancer	enh				GCACACAGGACCCCGAGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	direct	Highly Significant	NA				0.28954078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2315	chr1	162348427	162348448	162378637	162378658	74030	hg19					enhancer	enh				GAATGCAATTCCAAGTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf226	indirect	Non Significant	NA				-0.440485426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2316	chr1	167095550	167095571	167126313	167126334	74031	hg19					enhancer	enh				GAGTGGCAGAGCCGAAACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.392709557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2317	chr1	167095573	167095595	167126336	167126358	74032	hg19					enhancer	enh				GTACCAAGCAGAAGGGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.086049009									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2318	chr1	167095627	167095648	167126390	167126411	74033	hg19					enhancer	enh				GAGCGACGCTGGCTCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				0.097240368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2319	chr1	167095629	167095649	167126392	167126412	74034	hg19					enhancer	enh				GCGACGCTGGCTCCTCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.037550837									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2320	chr1	167095686	167095706	167126449	167126469	74035	hg19					enhancer	enh				GTGGCTGCTCACGCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.315882797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2321	chr1	167095690	167095712	167126453	167126475	74036	hg19					enhancer	enh				GAGCGTGAGCAGCCACGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.257792898									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2322	chr1	167095692	167095712	167126455	167126475	74037	hg19					enhancer	enh				GCGTGAGCAGCCACGACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.289132665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2323	chr1	167095705	167095725	167126468	167126488	74038	hg19					enhancer	enh				GCTTCAGGACCCAGATGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.43670718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2324	chr1	167095726	167095746	167126489	167126509	74039	hg19					enhancer	enh				GCAGCTGGAGCTGAACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-1.125404435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2325	chr1	167095732	167095753	167126495	167126516	74040	hg19					enhancer	enh				GGAGCTGAACCGCCCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.171469102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2326	chr1	167095733	167095753	167126496	167126516	74041	hg19					enhancer	enh				GAGCTGAACCGCCCGGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.216864946									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2327	chr1	167095738	167095760	167126501	167126523	74042	hg19					enhancer	enh				GAACCGCCCGGACCACGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				0.030150574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2328	chr1	167095744	167095764	167126507	167126527	74043	hg19					enhancer	enh				GCCTCCTGCCGTGGTCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	direct	Highly Significant	NA				0.214568139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2329	chr1	167095753	167095775	167126516	167126538	74044	hg19					enhancer	enh				GTCTGCGCGGCGCCTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.029151229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2330	chr1	167095797	167095818	167126560	167126581	74045	hg19					enhancer	enh				GCCTCTCGTTCCATGCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.016697363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2331	chr1	167095845	167095865	167126608	167126628	74046	hg19					enhancer	enh				GCTCTTGGCGTGGTACCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DUSP27	indirect	Non Significant	NA				-0.641963078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2332	chr1	171810523	171810543	171841383	171841403	74047	hg19					enhancer	enh				GGGCTTCCCATCGGACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				0.106516376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2333	chr1	171810658	171810680	171841518	171841540	74048	hg19					enhancer	enh				GGCGGGCTCCGACGTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				0.111280511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2334	chr1	171810659	171810680	171841519	171841540	74049	hg19					enhancer	enh				GCGGGCTCCGACGTCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.294733652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2335	chr1	171810668	171810690	171841528	171841550	74050	hg19					enhancer	enh				GACGTCTGCGCCAGGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	direct	Highly Significant	NA				0.33163538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2336	chr1	171810669	171810690	171841529	171841550	74051	hg19					enhancer	enh				GCCAGGTCCTGGCGCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	direct	Highly Significant	NA				0.32019041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2337	chr1	171810681	171810701	171841541	171841561	74052	hg19					enhancer	enh				GGGCTCAGCCAGCCAGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.528770145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2338	chr1	171810687	171810709	171841547	171841569	74053	hg19					enhancer	enh				GCTGCGCCGGGCTCAGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.112968012									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2339	chr1	171810720	171810741	171841580	171841601	74054	hg19					enhancer	enh				GGAGTAGGGGCCGCGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.424627802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2340	chr1	171810720	171810740	171841580	171841600	74055	hg19					enhancer	enh				GAGTAGGGGCCGCGCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				0.004882115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2341	chr1	171810743	171810763	171841603	171841623	74056	hg19					enhancer	enh				GCTCGCCTCTACGACCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				0.087374038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2342	chr1	171810743	171810763	171841603	171841623	74057	hg19					enhancer	enh				GTCAGGTCGTAGAGGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-1.328836999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2343	chr1	171810751	171810773	171841611	171841633	74058	hg19					enhancer	enh				GTAGAGGCGAGCAGGGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.184219098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2344	chr1	171810759	171810780	171841619	171841640	74059	hg19					enhancer	enh				GAGCAGGGACCAGCTGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	direct	Highly Significant	NA				0.30753269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2345	chr1	171810766	171810788	171841626	171841648	74060	hg19					enhancer	enh				GACCAGCTGGTCGCCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.153943026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2346	chr1	171810771	171810793	171841631	171841653	74061	hg19					enhancer	enh				GCCCGAGGGGCCGGCGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.351224339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2347	chr1	171810778	171810798	171841638	171841658	74062	hg19					enhancer	enh				GCCGGCCCCTCGGGCAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-0.132541886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2348	chr1	171810786	171810806	171841646	171841666	74063	hg19					enhancer	enh				GGTTCCCCATCTTGCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				0.130731066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2349	chr1	171810791	171810812	171841651	171841672	74064	hg19					enhancer	enh				GCAAGATGGGGAACCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNM3	indirect	Non Significant	NA				-1.550160826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2350	chr1	182026144	182026165	182057009	182057030	74065	hg19					enhancer	enh				GGTTTCTCGCCTGTGTGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.597392406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2351	chr1	182026160	182026180	182057025	182057045	74066	hg19					enhancer	enh				GGGTGCGGATGTGCTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.67450063									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2352	chr1	182026167	182026187	182057032	182057052	74067	hg19					enhancer	enh				GATGTGCTTCCGGTGGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.319312446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2353	chr1	182026172	182026193	182057037	182057058	74068	hg19					enhancer	enh				GCTTCCGGTGGTCGGAGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	direct	Highly Significant	NA				0.625679126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2354	chr1	182026233	182026253	182057098	182057118	74069	hg19					enhancer	enh				GGCGCCTGCACACGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				0.129105062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2355	chr1	182026241	182026261	182057106	182057126	74070	hg19					enhancer	enh				GCAGCACAGGCGCCTGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				0.10713356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2356	chr1	182026256	182026277	182057121	182057142	74071	hg19					enhancer	enh				GCTGCTGGAGTGTGCCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				0.079809804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2357	chr1	182026273	182026293	182057138	182057158	74072	hg19					enhancer	enh				GGGAAGGCCTACTCCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				0.018053865									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2358	chr1	182026273	182026295	182057138	182057160	74073	hg19					enhancer	enh				GCGGGAAGGCCTACTCCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.522049866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2359	chr1	182026293	182026315	182057158	182057180	74074	hg19					enhancer	enh				GCGCTACGCGTGCGAGCTATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				0.033860455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2360	chr1	182026293	182026313	182057158	182057178	74075	hg19					enhancer	enh				GCTACGCGTGCGAGCTATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	direct	Highly Significant	NA				1.210933508									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2361	chr1	182026327	182026348	182057192	182057213	74076	hg19					enhancer	enh				GAGCCCCGCGGAGACGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.236665581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2362	chr1	182026330	182026351	182057195	182057216	74077	hg19					enhancer	enh				GCTGAGCCCCGCGGAGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.410114224									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2363	chr1	182026349	182026370	182057214	182057235	74078	hg19					enhancer	enh				GCGGCTTGCTGGGCTTCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF648	indirect	Non Significant	NA				-0.541913681									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2364	chr1	202777348	202777368	202808220	202808240	74079	hg19					enhancer	enh				GAGGCAGGAACTCGCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	direct	Highly Significant	NA				0.231884733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2365	chr1	202777419	202777439	202808291	202808311	74080	hg19					enhancer	enh				GTGGCCGCCTCCATCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.136742155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2366	chr1	202777432	202777454	202808304	202808326	74081	hg19					enhancer	enh				GCCCTTGCCCAGCCTGCGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.300555237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2367	chr1	202777452	202777472	202808324	202808344	74082	hg19					enhancer	enh				GCGAGGCGAAGGTGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				0.099087812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2368	chr1	202777459	202777479	202808331	202808351	74083	hg19					enhancer	enh				GAAGGTGGGCTCCGGGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.624910269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2369	chr1	202777473	202777493	202808345	202808365	74084	hg19					enhancer	enh				GGAGCTCGCAGCCTCGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	direct	Highly Significant	NA				0.235149742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2370	chr1	202777473	202777495	202808345	202808367	74085	hg19					enhancer	enh				GCGGAGCTCGCAGCCTCGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.298809297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2371	chr1	202777474	202777496	202808346	202808368	74086	hg19					enhancer	enh				GACCGAGGCTGCGAGCTCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				0.081917771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2372	chr1	202777479	202777501	202808351	202808373	74087	hg19					enhancer	enh				GACCGAGCGGAGCTCGCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				0.173628909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2373	chr1	202777497	202777518	202808369	202808390	74088	hg19					enhancer	enh				GGTCCGAGACCCGTGCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.782570627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2374	chr1	202777498	202777518	202808370	202808390	74089	hg19					enhancer	enh				GTCCGAGACCCGTGCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	direct	Highly Significant	NA				0.406230442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2375	chr1	202777509	202777531	202808381	202808403	74090	hg19					enhancer	enh				GTTGCTCGAGCCGCGTCTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	indirect	Non Significant	NA				-0.234545385									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2376	chr1	202777510	202777531	202808382	202808403	74091	hg19					enhancer	enh				GTTGCTCGAGCCGCGTCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM5B	direct	Highly Significant	NA				0.428230075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2377	chr1	202778143	202778163	202809015	202809035	74092	hg19					enhancer	enh				GCAATTTGCCATAATTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.457335525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2378	chr1	202778167	202778187	202809039	202809059	74093	hg19					enhancer	enh				GTAATAAGTGATGGAGACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091406503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2379	chr1	202778168	202778188	202809040	202809060	74094	hg19					enhancer	enh				GAATAAGTGATGGAGACTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217585688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2380	chr1	202778171	202778191	202809043	202809063	74095	hg19					enhancer	enh				GAAGTGATGGAGACTATTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207321073									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2381	chr1	202778174	202778194	202809046	202809066	74096	hg19					enhancer	enh				GTGATGGAGACTATTGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.430155887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2382	chr1	202778220	202778240	202809092	202809112	74097	hg19					enhancer	enh				GTCCACAAACAGTCTATGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.369443775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2383	chr1	202778224	202778244	202809096	202809116	74098	hg19					enhancer	enh				GACCTCGTCATAGACTGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.03228821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2384	chr1	202778234	202778254	202809106	202809126	74099	hg19					enhancer	enh				GATGACGAGGTCAGACTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101314765									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2385	chr1	202778235	202778255	202809107	202809127	74100	hg19					enhancer	enh				GTGACGAGGTCAGACTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.188216527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2386	chr1	202778236	202778256	202809108	202809128	74101	hg19					enhancer	enh				GACGAGGTCAGACTTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.071184502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2387	chr1	202778264	202778284	202809136	202809156	74102	hg19					enhancer	enh				GACTTGAAATAATCCAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.604373574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2388	chr1	202778273	202778293	202809145	202809165	74103	hg19					enhancer	enh				GTAATCCAGACAAGGAATGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.228922703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2389	chr1	202778286	202778306	202809158	202809178	74104	hg19					enhancer	enh				GAATGATAGGATCTAAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280120847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2390	chr1	202778292	202778312	202809164	202809184	74105	hg19					enhancer	enh				GTAGGATCTAAATTAAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.699415306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2391	chr1	202778309	202778329	202809181	202809201	74106	hg19					enhancer	enh				GCAGTGGTGCTGATAATTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.501331823									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2392	chr1	202778313	202778333	202809185	202809205	74107	hg19					enhancer	enh				GGTGCTGATAATTATGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108630888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2393	chr1	202778314	202778334	202809186	202809206	74108	hg19					enhancer	enh				GTGCTGATAATTATGAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.291740064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2394	chr1	202778327	202778347	202809199	202809219	74109	hg19					enhancer	enh				GTGAGGAAGGGATGCAAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.666827623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2395	chr1	202778359	202778379	202809231	202809251	74110	hg19					enhancer	enh				GTAGGACATAGTGACAGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.343151269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2396	chr1	202778360	202778380	202809232	202809252	74111	hg19					enhancer	enh				GAGGACATAGTGACAGATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.51328627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2397	chr1	202778361	202778381	202809233	202809253	74112	hg19					enhancer	enh				GGACATAGTGACAGATTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.314604553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2398	chr1	202778362	202778382	202809234	202809254	74113	hg19					enhancer	enh				GACATAGTGACAGATTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.645172421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2399	chr1	202778363	202778383	202809235	202809255	74114	hg19					enhancer	enh				GACATAGTGACAGATTGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.514772575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2400	chr1	202778393	202778413	202809265	202809285	74115	hg19					enhancer	enh				GGTATTAAGATTCAGATGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.411817738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2401	chr1	202778423	202778443	202809295	202809315	74116	hg19					enhancer	enh				GGGCTAGCATCTACTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217915055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2402	chr1	202778425	202778445	202809297	202809317	74117	hg19					enhancer	enh				GCTGAGTAGATGCTAGCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.499158434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2403	chr1	202778427	202778447	202809299	202809319	74118	hg19					enhancer	enh				GCAACGGGCTAGCATCTACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116713309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2404	chr1	202778434	202778454	202809306	202809326	74119	hg19					enhancer	enh				GTGCTAGCCCGTTGGCATTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.276671327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2405	chr1	202778443	202778463	202809315	202809335	74120	hg19					enhancer	enh				GAATGTTCCAGCAATGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.654861098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2406	chr1	202778444	202778464	202809316	202809336	74121	hg19					enhancer	enh				GAATGTTCCAGCAATGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.819277703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2407	chr1	202778462	202778482	202809334	202809354	74122	hg19					enhancer	enh				GTCACCCCAATTATATACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.371114172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2408	chr1	202778476	202778496	202809348	202809368	74123	hg19					enhancer	enh				GTACAGAAGGCGAGTTACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158990279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2409	chr1	202778538	202778558	202809410	202809430	74124	hg19					enhancer	enh				GAGGTGTCTCTGGTACATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.335460137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2410	chr1	202778554	202778574	202809426	202809446	74125	hg19					enhancer	enh				GATACAGGTAGAAATACACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075570421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2411	chr1	202778555	202778575	202809427	202809447	74126	hg19					enhancer	enh				GTACAGGTAGAAATACACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.780812136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2412	chr1	202778577	202778597	202809449	202809469	74127	hg19					enhancer	enh				GGTATCCTTCAACAGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.676906217									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2413	chr1	202778578	202778598	202809450	202809470	74128	hg19					enhancer	enh				GTATCCTTCAACAGACTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238964501									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2414	chr1	202778592	202778612	202809464	202809484	74129	hg19					enhancer	enh				GACTGAAGGGTATAAATCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.425535678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2415	chr1	202778593	202778613	202809465	202809485	74130	hg19					enhancer	enh				GCTGAAGGGTATAAATCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.446283042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2416	chr1	202778594	202778614	202809466	202809486	74131	hg19					enhancer	enh				GTGAAGGGTATAAATCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032985599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2417	chr1	202778609	202778629	202809481	202809501	74132	hg19					enhancer	enh				GTGAAGGGGCGAGATCAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.418313079									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2418	chr1	202778623	202778643	202809495	202809515	74133	hg19					enhancer	enh				GCAGAATTGGAGATATAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.475856457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2419	chr1	202778624	202778644	202809496	202809516	74134	hg19					enhancer	enh				GAGAATTGGAGATATAAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.697959084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2420	chr1	202778673	202778693	202809545	202809565	74135	hg19					enhancer	enh				GCACACAGTAGCATTAAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175945767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2421	chr1	202778739	202778759	202809611	202809631	74136	hg19					enhancer	enh				GTCACAACCACCATATTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.109306855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2422	chr1	202778748	202778768	202809620	202809640	74137	hg19					enhancer	enh				GATCGTACCTACTCAATATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145767089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2423	chr1	202778751	202778771	202809623	202809643	74138	hg19					enhancer	enh				GAATATCGTACCTACTCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.474066265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2424	chr1	202778786	202778806	202809658	202809678	74139	hg19					enhancer	enh				GAGCAGGCAACGGAGGCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.367953481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2425	chr1	202778849	202778869	202809721	202809741	74140	hg19					enhancer	enh				GTCTCCCGCCAAAAGAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142495422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2426	chr1	202778893	202778913	202809765	202809785	74141	hg19					enhancer	enh				GTCCAGCAGCCTCAGAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.774105641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2427	chr1	202778896	202778916	202809768	202809788	74142	hg19					enhancer	enh				GCAGCAGCCTCAGAAAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.590465326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2428	chr1	202778956	202778976	202809828	202809848	74143	hg19					enhancer	enh				GGCAGCTTTCTGGATGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225252591									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2429	chr1	202778966	202778986	202809838	202809858	74144	hg19					enhancer	enh				GCATACGTTTGGCAGCTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.541797567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2430	chr1	202778967	202778987	202809839	202809859	74145	hg19					enhancer	enh				GAAAGCTGCCAAACGTATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.027739355									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2431	chr1	202778977	202778997	202809849	202809869	74146	hg19					enhancer	enh				GAAACATTCCTTGCATACGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.567100768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2432	chr1	202779011	202779031	202809883	202809903	74147	hg19					enhancer	enh				GTCGCTTTCAGATTCACCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.59365452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2433	chr1	202779015	202779035	202809887	202809907	74148	hg19					enhancer	enh				GTTTCAGATTCACCTAGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.698924919									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2434	chr1	202779029	202779049	202809901	202809921	74149	hg19					enhancer	enh				GATAAGAGATTTCCTTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.514138133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2435	chr1	202779051	202779071	202809923	202809943	74150	hg19					enhancer	enh				GTTAAGAAGTCTTCAATTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.148537769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2436	chr1	202779052	202779072	202809924	202809944	74151	hg19					enhancer	enh				GTAAGAAGTCTTCAATTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.196988723									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2437	chr1	202779053	202779073	202809925	202809945	74152	hg19					enhancer	enh				GAAGAAGTCTTCAATTAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.280108366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2438	chr1	202779054	202779074	202809926	202809946	74153	hg19					enhancer	enh				GAGAAGTCTTCAATTAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104798774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2439	chr1	202779055	202779075	202809927	202809947	74154	hg19					enhancer	enh				GAAGTCTTCAATTAAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228709658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2440	chr1	202779059	202779079	202809931	202809951	74155	hg19					enhancer	enh				GTCTTCAATTAAAAGGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295674604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2441	chr1	202779060	202779080	202809932	202809952	74156	hg19					enhancer	enh				GCTTCAATTAAAAGGGGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.297312509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2442	chr1	202779107	202779127	202809979	202809999	74157	hg19					enhancer	enh				GGAAAAATTTGTTGAAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.533393598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2443	chr1	202779111	202779131	202809983	202810003	74158	hg19					enhancer	enh				GTCTGGGAAAAATTTGTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.420147409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2444	chr1	202779112	202779132	202809984	202810004	74159	hg19					enhancer	enh				GCTCTGGGAAAAATTTGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.486903699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2445	chr1	202779123	202779143	202809995	202810015	74160	hg19					enhancer	enh				GTTCCCAGAGGTACCGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.99713076									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2446	chr1	202779128	202779148	202810000	202810020	74161	hg19					enhancer	enh				GTTCCTGGGCCCGGTACCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.4831029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2447	chr1	202779129	202779149	202810001	202810021	74162	hg19					enhancer	enh				GTTTCCTGGGCCCGGTACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099630944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2448	chr1	202779138	202779158	202810010	202810030	74163	hg19					enhancer	enh				GTGTGAACTCTTTCCTGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248847965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2449	chr1	202779139	202779159	202810011	202810031	74164	hg19					enhancer	enh				GCCCAGGAAAGAGTTCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025708786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2450	chr1	202779143	202779163	202810015	202810035	74165	hg19					enhancer	enh				GACCACTGTGAACTCTTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.372924674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2451	chr1	202779144	202779164	202810016	202810036	74166	hg19					enhancer	enh				GACCACTGTGAACTCTTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.24543005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2452	chr1	202779145	202779165	202810017	202810037	74167	hg19					enhancer	enh				GAAAGAGTTCACAGTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057478724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2453	chr1	202779146	202779166	202810018	202810038	74168	hg19					enhancer	enh				GAAAGAGTTCACAGTGGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.743783821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2454	chr1	202779166	202779186	202810038	202810058	74169	hg19					enhancer	enh				GAAAAGGAATACGTTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051559185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2455	chr1	202779182	202779202	202810054	202810074	74170	hg19					enhancer	enh				GAGCCCTGGAGAGCTAAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.031615922									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2456	chr1	202779190	202779210	202810062	202810082	74171	hg19					enhancer	enh				GCTCTCCAGGGCTTTGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130259128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2457	chr1	202779197	202779217	202810069	202810089	74172	hg19					enhancer	enh				GACTCCAGGTCCCAAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086018011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2458	chr1	202779211	202779231	202810083	202810103	74173	hg19					enhancer	enh				GAGGGAGCAGGAAAAGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.25165274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2459	chr1	202779218	202779238	202810090	202810110	74174	hg19					enhancer	enh				GTTTCCTGCTCCCTACTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336206883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2460	chr1	202779224	202779244	202810096	202810116	74175	hg19					enhancer	enh				GTCTCCATTGCAGTAGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016201856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2461	chr1	202779230	202779250	202810102	202810122	74176	hg19					enhancer	enh				GCTTGACTCTCCATTGCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.732416374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2462	chr1	202779231	202779251	202810103	202810123	74177	hg19					enhancer	enh				GCTTGACTCTCCATTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.268962293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2463	chr1	202779233	202779253	202810105	202810125	74178	hg19					enhancer	enh				GTGCAATGGAGAGTCAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.245469916									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2464	chr1	202779234	202779254	202810106	202810126	74179	hg19					enhancer	enh				GCAATGGAGAGTCAAGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.506233513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2465	chr1	202779235	202779255	202810107	202810127	74180	hg19					enhancer	enh				GCAATGGAGAGTCAAGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373230254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2466	chr1	202779254	202779274	202810126	202810146	74181	hg19					enhancer	enh				GATAGTGTATTAGCTGTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.076258573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2467	chr1	202779289	202779309	202810161	202810181	74182	hg19					enhancer	enh				GTGCAAGATAGATATGCGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265627339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2468	chr1	202779310	202779330	202810182	202810202	74183	hg19					enhancer	enh				GGCAAGTTATAATAGAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092668823									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2469	chr1	202779316	202779336	202810188	202810208	74184	hg19					enhancer	enh				GTTATAATAGAATCTAGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.218019161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2470	chr1	202779317	202779337	202810189	202810209	74185	hg19					enhancer	enh				GTATAATAGAATCTAGGTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101678367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2471	chr1	202779325	202779345	202810197	202810217	74186	hg19					enhancer	enh				GAATCTAGGTAGTGGGTATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.063474914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2472	chr1	202779407	202779427	202810279	202810299	74187	hg19					enhancer	enh				GGTAGAAGAATTATCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.062285915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2473	chr1	202779437	202779457	202810309	202810329	74188	hg19					enhancer	enh				GTGCGCATTCTGGGCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.306289609									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2474	chr1	202779438	202779458	202810310	202810330	74189	hg19					enhancer	enh				GTGCGCATTCTGGGCCTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.022539397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2475	chr1	202779454	202779474	202810326	202810346	74190	hg19					enhancer	enh				GAGCTTCATCAAGACCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.788347308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2476	chr1	202779457	202779477	202810329	202810349	74191	hg19					enhancer	enh				GATGAGCTTCATCAAGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39611464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2477	chr1	202779524	202779544	202810396	202810416	74192	hg19					enhancer	enh				GCTCGTAGGATGCCAACGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.063192824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2478	chr1	202779525	202779545	202810397	202810417	74193	hg19					enhancer	enh				GACGTTGGCATCCTACGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.510466493									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2479	chr1	202779529	202779549	202810401	202810421	74194	hg19					enhancer	enh				GTGGCATCCTACGAGCCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.37669178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2480	chr1	202779538	202779558	202810410	202810430	74195	hg19					enhancer	enh				GTTATGCCTACCTGGCTCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052669606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2481	chr1	202779546	202779566	202810418	202810438	74196	hg19					enhancer	enh				GTCTCAAAGTTATGCCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.137132043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2482	chr1	202779594	202779614	202810466	202810486	74197	hg19					enhancer	enh				GATTATTTAACTGAGATGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265742344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2483	chr1	202779644	202779664	202810516	202810536	74198	hg19					enhancer	enh				GTAGGACGCAGCTGAGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.010765988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2484	chr1	202779645	202779665	202810517	202810537	74199	hg19					enhancer	enh				GCGTAGGACGCAGCTGAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.27170117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2485	chr1	202779669	202779689	202810541	202810561	74200	hg19					enhancer	enh				GCCTCTCGCTCCCAACTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083975173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2486	chr1	202779671	202779691	202810543	202810563	74201	hg19					enhancer	enh				GCTTGAGAGTTGGGAGCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.226175185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2487	chr1	202779672	202779692	202810544	202810564	74202	hg19					enhancer	enh				GCCTTGAGAGTTGGGAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23722334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2488	chr1	202779681	202779701	202810553	202810573	74203	hg19					enhancer	enh				GACTGGGAGACCTTGAGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.120948187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2489	chr1	202779682	202779702	202810554	202810574	74204	hg19					enhancer	enh				GACTCTCAAGGTCTCCCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.879668922									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2490	chr1	202779682	202779702	202810554	202810574	74205	hg19					enhancer	enh				GACTGGGAGACCTTGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13413646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2491	chr1	202779698	202779718	202810570	202810590	74206	hg19					enhancer	enh				GAGTCCGGCTTCCTCCATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.159889994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2492	chr1	202779698	202779718	202810570	202810590	74207	hg19					enhancer	enh				GAAATGGAGGAAGCCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.419154318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2493	chr1	202779699	202779719	202810571	202810591	74208	hg19					enhancer	enh				GGAAATGGAGGAAGCCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099960479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2494	chr1	202779704	202779724	202810576	202810596	74209	hg19					enhancer	enh				GCTACCGGAAATGGAGGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207249169									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2495	chr1	202779711	202779731	202810583	202810603	74210	hg19					enhancer	enh				GAGGGTCACTACCGGAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.437196784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2496	chr1	202779714	202779734	202810586	202810606	74211	hg19					enhancer	enh				GCTTAGGGTCACTACCGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.498893294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2497	chr1	202779720	202779740	202810592	202810612	74212	hg19					enhancer	enh				GTCATCACTTAGGGTCACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135146422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2498	chr1	202779730	202779750	202810602	202810622	74213	hg19					enhancer	enh				GCGATAGAATCTCATCACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257242014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2499	chr1	202779731	202779751	202810603	202810623	74214	hg19					enhancer	enh				GCGATAGAATCTCATCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.035362928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2500	chr1	202779740	202779760	202810612	202810632	74215	hg19					enhancer	enh				GATTCTATCGCTCCCAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.506614145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2501	chr1	202779754	202779774	202810626	202810646	74216	hg19					enhancer	enh				GCAGATCAGGCCGCAGCTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119082324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2502	chr1	202779755	202779775	202810627	202810647	74217	hg19					enhancer	enh				GAAACAGCTGCGGCCTGATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.333641731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2503	chr1	202779756	202779776	202810628	202810648	74218	hg19					enhancer	enh				GCAAACAGCTGCGGCCTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09032967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2504	chr1	202779766	202779786	202810638	202810658	74219	hg19					enhancer	enh				GTGCTGGGAGCCAAACAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153703648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2505	chr1	202779770	202779790	202810642	202810662	74220	hg19					enhancer	enh				GTGTTTGGCTCCCAGCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.68863772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2506	chr1	202779782	202779802	202810654	202810674	74221	hg19					enhancer	enh				GAACGTCACACCGGGTCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.025828604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2507	chr1	202779783	202779803	202810655	202810675	74222	hg19					enhancer	enh				GTAACGTCACACCGGGTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.626449258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2508	chr1	202779783	202779803	202810655	202810675	74223	hg19					enhancer	enh				GCAGACCCGGTGTGACGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.948389112									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2509	chr1	202779784	202779804	202810656	202810676	74224	hg19					enhancer	enh				GCAGACCCGGTGTGACGTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.181990512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2510	chr1	202779788	202779808	202810660	202810680	74225	hg19					enhancer	enh				GCCCGGTGTGACGTTAAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.458466261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2511	chr1	202779789	202779809	202810661	202810681	74226	hg19					enhancer	enh				GCCGGTGTGACGTTAAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.954171773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2512	chr1	202779790	202779810	202810662	202810682	74227	hg19					enhancer	enh				GCGGTGTGACGTTAAGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.089615834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2513	chr1	202779791	202779811	202810663	202810683	74228	hg19					enhancer	enh				GCCGTCCCTTAACGTCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.272906716									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2514	chr1	202779792	202779812	202810664	202810684	74229	hg19					enhancer	enh				GCCCGTCCCTTAACGTCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.129276603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2515	chr1	202779810	202779830	202810682	202810702	74230	hg19					enhancer	enh				GGGCGGTTGCCGGCGTCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.408924325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2516	chr1	202779811	202779831	202810683	202810703	74231	hg19					enhancer	enh				GGCGGTTGCCGGCGTCTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062412405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2517	chr1	202779812	202779832	202810684	202810704	74232	hg19					enhancer	enh				GCGGTTGCCGGCGTCTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096247803									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2518	chr1	202779820	202779840	202810692	202810712	74233	hg19					enhancer	enh				GCGGCGTCTTGAGGGGAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.989157409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2519	chr1	202779821	202779841	202810693	202810713	74234	hg19					enhancer	enh				GGCGTCTTGAGGGGAACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124914348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2520	chr1	202779822	202779842	202810694	202810714	74235	hg19					enhancer	enh				GCTAGGTTCCCCTCAAGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.500806971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2521	chr1	202779830	202779850	202810702	202810722	74236	hg19					enhancer	enh				GAGGGGAACCTAGGGACCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.462708755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2522	chr1	202779839	202779859	202810711	202810731	74237	hg19					enhancer	enh				GTAGGGACCGAGAGGACTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.332440007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2523	chr1	202779840	202779860	202810712	202810732	74238	hg19					enhancer	enh				GGAGAGTCCTCTCGGTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084566661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2524	chr1	202779840	202779860	202810712	202810732	74239	hg19					enhancer	enh				GAGGGACCGAGAGGACTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.54340121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2525	chr1	202779844	202779864	202810716	202810736	74240	hg19					enhancer	enh				GACCGAGAGGACTCTCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.35369753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2526	chr1	202779848	202779868	202810720	202810740	74241	hg19					enhancer	enh				GCCTTCCCGGAGAGTCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099538463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2527	chr1	202779861	202779881	202810733	202810753	74242	hg19					enhancer	enh				GCGGGGGAGCGGCTGCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.380772177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2528	chr1	202779884	202779904	202810756	202810776	74243	hg19					enhancer	enh				GCAAGGGGAGCGTCTGTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.103103691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2529	chr1	202779885	202779905	202810757	202810777	74244	hg19					enhancer	enh				GGCAAGGGGAGCGTCTGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.526693422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2530	chr1	202779899	202779919	202810771	202810791	74245	hg19					enhancer	enh				GTAAACATCATAAAGGGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.293919503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2531	chr1	202779900	202779920	202810772	202810792	74246	hg19					enhancer	enh				GTAAACATCATAAAGGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.434662712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2532	chr1	202779901	202779921	202810773	202810793	74247	hg19					enhancer	enh				GTGTAAACATCATAAAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220751678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2533	chr1	202779906	202779926	202810778	202810798	74248	hg19					enhancer	enh				GCCCATGTAAACATCATAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.041812224									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2534	chr1	202779907	202779927	202810779	202810799	74249	hg19					enhancer	enh				GCGCCCATGTAAACATCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177198005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2535	chr1	202779908	202779928	202810780	202810800	74250	hg19					enhancer	enh				GTATGATGTTTACATGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200423066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2536	chr1	202779909	202779929	202810781	202810801	74251	hg19					enhancer	enh				GATGATGTTTACATGGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.234073921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2537	chr1	202779937	202779957	202810809	202810829	74252	hg19					enhancer	enh				GGTGTGGCTGTCAGCTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.616690117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2538	chr1	202779941	202779961	202810813	202810833	74253	hg19					enhancer	enh				GAGCTGACAGCCACACCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217585879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2539	chr1	202779941	202779961	202810813	202810833	74254	hg19					enhancer	enh				GCGCGGTGTGGCTGTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.316733722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2540	chr1	202779942	202779962	202810814	202810834	74255	hg19					enhancer	enh				GGCGCGGTGTGGCTGTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.097065715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2541	chr1	202779958	202779978	202810830	202810850	74256	hg19					enhancer	enh				GTAAAAAAAGAAGGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.842914327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2542	chr1	202779968	202779988	202810840	202810860	74257	hg19					enhancer	enh				GCTAGGCTCTTTAAAAAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.399082638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2543	chr1	202779982	202780002	202810854	202810874	74258	hg19					enhancer	enh				GCCTAGCCACGGGCGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195937238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2544	chr1	202779986	202780006	202810858	202810878	74259	hg19					enhancer	enh				GAGCCACGGGCGCTGACTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.459601329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2545	chr1	202779986	202780006	202810858	202810878	74260	hg19					enhancer	enh				GCCAGTCAGCGCCCGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.098778055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2546	chr1	202779991	202780011	202810863	202810883	74261	hg19					enhancer	enh				GTGCCGGCCAGTCAGCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.295842881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2547	chr1	202779993	202780013	202810865	202810885	74262	hg19					enhancer	enh				GGCGCTGACTGGCCGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.235097428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2548	chr1	202779994	202780014	202810866	202810886	74263	hg19					enhancer	enh				GCGCTGACTGGCCGGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178891991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2549	chr1	202780008	202780028	202810880	202810900	74264	hg19					enhancer	enh				GAGGATGACGCGCCCGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.410320383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2550	chr1	202780009	202780029	202810881	202810901	74265	hg19					enhancer	enh				GCAGCCGGGCGCGTCATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.400227171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2551	chr1	202780010	202780030	202810882	202810902	74266	hg19					enhancer	enh				GAGCCGGGCGCGTCATCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225139623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2552	chr1	202780011	202780031	202810883	202810903	74267	hg19					enhancer	enh				GCCGGGCGCGTCATCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.077680375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2553	chr1	202780012	202780032	202810884	202810904	74268	hg19					enhancer	enh				GCCGGGCGCGTCATCCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.163169511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2554	chr1	202780015	202780035	202810887	202810907	74269	hg19					enhancer	enh				GGCGCGTCATCCTCCGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.48373992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2555	chr1	202780015	202780035	202810887	202810907	74270	hg19					enhancer	enh				GCCCCCGGAGGATGACGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.285867983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2556	chr1	202780016	202780036	202810888	202810908	74271	hg19					enhancer	enh				GCGCGTCATCCTCCGGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.277192487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2557	chr1	202780017	202780037	202810889	202810909	74272	hg19					enhancer	enh				GCGCGTCATCCTCCGGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.191882175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2558	chr1	202780022	202780042	202810894	202810914	74273	hg19					enhancer	enh				GCATCCTCCGGGGGCGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.168980285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2559	chr1	202780023	202780043	202810895	202810915	74274	hg19					enhancer	enh				GATCCTCCGGGGGCGGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.747623125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2560	chr1	202780042	202780062	202810914	202810934	74275	hg19					enhancer	enh				GCGGGCCGCATTGTCTCGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.002639497									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2561	chr1	202780043	202780063	202810915	202810935	74276	hg19					enhancer	enh				GGGCCGCATTGTCTCGTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.502701115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2562	chr1	202780043	202780063	202810915	202810935	74277	hg19					enhancer	enh				GTAGACGAGACAATGCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046999708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2563	chr1	202780044	202780064	202810916	202810936	74278	hg19					enhancer	enh				GCTAGACGAGACAATGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.493287908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2564	chr1	202780047	202780067	202810919	202810939	74279	hg19					enhancer	enh				GCGCATTGTCTCGTCTAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026520818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2565	chr1	202780049	202780069	202810921	202810941	74280	hg19					enhancer	enh				GCGGCCCTAGACGAGACAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.300044296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2566	chr1	202780051	202780071	202810923	202810943	74281	hg19					enhancer	enh				GTTGTCTCGTCTAGGGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.797284008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2567	chr1	202780063	202780083	202810935	202810955	74282	hg19					enhancer	enh				GGGCCGGCTGGACGCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.481455145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2568	chr1	202780067	202780087	202810939	202810959	74283	hg19					enhancer	enh				GCGGCTGGACGCCCCAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.304056846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2569	chr1	202780069	202780089	202810941	202810961	74284	hg19					enhancer	enh				GCGGCCTCTGGGGCGTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.42608148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2570	chr1	202780073	202780093	202810945	202810965	74285	hg19					enhancer	enh				GACGCCCCAGAGGCCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.376936699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2571	chr1	202780074	202780094	202810946	202810966	74286	hg19					enhancer	enh				GACGCCCCAGAGGCCGGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025705769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2572	chr1	202780080	202780100	202810952	202810972	74287	hg19					enhancer	enh				GTTGCCCAGGTCCGGCCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.678017006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2573	chr1	202780081	202780101	202810953	202810973	74288	hg19					enhancer	enh				GTTGCCCAGGTCCGGCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.189097513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2574	chr1	202780082	202780102	202810954	202810974	74289	hg19					enhancer	enh				GGTTGCCCAGGTCCGGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.142897035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2575	chr1	202780088	202780108	202810960	202810980	74290	hg19					enhancer	enh				GGACCTGGGCAACCCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107323282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2576	chr1	202780089	202780109	202810961	202810981	74291	hg19					enhancer	enh				GAGGCTGGGGTTGCCCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.095602486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2577	chr1	202780094	202780114	202810966	202810986	74292	hg19					enhancer	enh				GCCTCCAGGCTGGGGTTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.779472708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2578	chr1	202780097	202780117	202810969	202810989	74293	hg19					enhancer	enh				GCAACCCCAGCCTGGAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.579816728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2579	chr1	202780098	202780118	202810970	202810990	74294	hg19					enhancer	enh				GAACCCCAGCCTGGAGGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.068132553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2580	chr1	202780099	202780119	202810971	202810991	74295	hg19					enhancer	enh				GACCCCAGCCTGGAGGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092256677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2581	chr1	202780104	202780124	202810976	202810996	74296	hg19					enhancer	enh				GGCCCCGGCACCTCCAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.257113227									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2582	chr1	202780105	202780125	202810977	202810997	74297	hg19					enhancer	enh				GCGGCCCCGGCACCTCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.41039711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2583	chr1	202780109	202780129	202810981	202811001	74298	hg19					enhancer	enh				GCTCCGGCCCCGGCACCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305970486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2584	chr1	202780128	202780148	202811000	202811020	74299	hg19					enhancer	enh				GCTCCCAGAGGGCTGGGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.020651851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2585	chr1	202780133	202780153	202811005	202811025	74300	hg19					enhancer	enh				GGCCTCGCACCCAGCCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.138238467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2586	chr1	202780134	202780154	202811006	202811026	74301	hg19					enhancer	enh				GAGGCCTCGCACCCAGCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432770596									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2587	chr1	202780149	202780169	202811021	202811041	74302	hg19					enhancer	enh				GGCCTAGGCGGGGTCAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142442172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2588	chr1	202780150	202780170	202811022	202811042	74303	hg19					enhancer	enh				GCCTAGGCGGGGTCAGGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.228615925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2589	chr1	202780154	202780174	202811026	202811046	74304	hg19					enhancer	enh				GACCCGAACCTGACCCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.472611309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2590	chr1	202780158	202780178	202811030	202811050	74305	hg19					enhancer	enh				GGGGTCAGGTTCGGGTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.318255695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2591	chr1	202780167	202780187	202811039	202811059	74306	hg19					enhancer	enh				GTTCGGGTTCCTAGGCCATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.539270951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2592	chr1	202780178	202780198	202811050	202811070	74307	hg19					enhancer	enh				GCTGCAGCTCCGCTATGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.267148447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2593	chr1	202780181	202780201	202811053	202811073	74308	hg19					enhancer	enh				GCCATAGCGGAGCTGCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.343839487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2594	chr1	202780184	202780204	202811056	202811076	74309	hg19					enhancer	enh				GTAGCGGAGCTGCAGCCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.304997524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2595	chr1	202780184	202780204	202811056	202811076	74310	hg19					enhancer	enh				GCCTGGGCTGCAGCTCCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.116645989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2596	chr1	202780188	202780208	202811060	202811080	74311	hg19					enhancer	enh				GGAGCTGCAGCCCAGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027916226									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2597	chr1	202780193	202780213	202811065	202811085	74312	hg19					enhancer	enh				GTGCAGCCCAGGCGGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086405421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2598	chr1	202780201	202780221	202811073	202811093	74313	hg19					enhancer	enh				GGGTTCCGCTCCGGCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007138121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2599	chr1	202780202	202780222	202811074	202811094	74314	hg19					enhancer	enh				GTGGGTTCCGCTCCGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262127251									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2600	chr1	202780210	202780230	202811082	202811102	74315	hg19					enhancer	enh				GAGCGGGGCTGGGTTCCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227229481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2601	chr1	202780221	202780241	202811093	202811113	74316	hg19					enhancer	enh				GTGGCACTCGGAGCGGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.857866304									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2602	chr1	202780226	202780246	202811098	202811118	74317	hg19					enhancer	enh				GAGACGTGGCACTCGGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.968272601									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2603	chr1	202780227	202780247	202811099	202811119	74318	hg19					enhancer	enh				GCTCCGAGTGCCACGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233853095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2604	chr1	202780227	202780247	202811099	202811119	74319	hg19					enhancer	enh				GGAGACGTGGCACTCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.350963918									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2605	chr1	202780228	202780248	202811100	202811120	74320	hg19					enhancer	enh				GTGGAGACGTGGCACTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.52983873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2606	chr1	202780233	202780253	202811105	202811125	74321	hg19					enhancer	enh				GTTCCTGGAGACGTGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15899965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2607	chr1	202780247	202780267	202811119	202811139	74322	hg19					enhancer	enh				GAGGAACCCCCTCCTTACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.313020118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2608	chr1	202780248	202780268	202811120	202811140	74323	hg19					enhancer	enh				GAAGAGTAAGGAGGGGGTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.39830255									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2609	chr1	202780255	202780275	202811127	202811147	74324	hg19					enhancer	enh				GTTGTCCAAGAGTAAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.22589313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2610	chr1	202780256	202780276	202811128	202811148	74325	hg19					enhancer	enh				GTGTTGTCCAAGAGTAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.231716368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2611	chr1	202780257	202780277	202811129	202811149	74326	hg19					enhancer	enh				GTGTTGTCCAAGAGTAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012725807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2612	chr1	202780258	202780278	202811130	202811150	74327	hg19					enhancer	enh				GAGTGTTGTCCAAGAGTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.612413323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2613	chr1	202780261	202780281	202811133	202811153	74328	hg19					enhancer	enh				GCGGAGTGTTGTCCAAGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.160480087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2614	chr1	202780269	202780289	202811141	202811161	74329	hg19					enhancer	enh				GACAACACTCCGCCCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012288125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2615	chr1	202780270	202780290	202811142	202811162	74330	hg19					enhancer	enh				GACAACACTCCGCCCCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.283692289									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2616	chr1	202780303	202780323	202811175	202811195	74331	hg19					enhancer	enh				GCACAAATGAGGGCGGTTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.075961299									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2617	chr1	202780304	202780324	202811176	202811196	74332	hg19					enhancer	enh				GCACAAATGAGGGCGGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.085604697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2618	chr1	202780305	202780325	202811177	202811197	74333	hg19					enhancer	enh				GTGCACAAATGAGGGCGGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.047124789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2619	chr1	202780306	202780326	202811178	202811198	74334	hg19					enhancer	enh				GCTGCACAAATGAGGGCGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432268604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2620	chr1	202780311	202780331	202811183	202811203	74335	hg19					enhancer	enh				GTGGCGCTGCACAAATGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.616755242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2621	chr1	202780315	202780335	202811187	202811207	74336	hg19					enhancer	enh				GATCTGGCGCTGCACAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.755110467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2622	chr1	202780318	202780338	202811190	202811210	74337	hg19					enhancer	enh				GTTGTGCAGCGCCAGATCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.472601256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2623	chr1	202780331	202780351	202811203	202811223	74338	hg19					enhancer	enh				GAGGGATGTGTCCGAAGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.561894112									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2624	chr1	202780331	202780351	202811203	202811223	74339	hg19					enhancer	enh				GATCCTTCGGACACATCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.500246221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2625	chr1	202780337	202780357	202811209	202811229	74340	hg19					enhancer	enh				GACACCTAGGGATGTGTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.369259792									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2626	chr1	202780350	202780370	202811222	202811242	74341	hg19					enhancer	enh				GAATGAGGATGGAGACACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.013314364									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2627	chr1	202780351	202780371	202811223	202811243	74342	hg19					enhancer	enh				GAATGAGGATGGAGACACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.307573731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2628	chr1	202780362	202780382	202811234	202811254	74343	hg19					enhancer	enh				GTTGGATGGACCGAATGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050618854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2629	chr1	202780366	202780386	202811238	202811258	74344	hg19					enhancer	enh				GGAGTTGGATGGACCGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.194885573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2630	chr1	202780381	202780401	202811253	202811273	74345	hg19					enhancer	enh				GTTGACGTGAGGTCTGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.327972106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2631	chr1	202780382	202780402	202811254	202811274	74346	hg19					enhancer	enh				GCTCCCAGACCTCACGTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.697536725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2632	chr1	202780387	202780407	202811259	202811279	74347	hg19					enhancer	enh				GAGCCGGTTGACGTGAGGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.355200349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2633	chr1	202780393	202780413	202811265	202811285	74348	hg19					enhancer	enh				GGGTGCAGCCGGTTGACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167975163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2634	chr1	202780404	202780424	202811276	202811296	74349	hg19					enhancer	enh				GCTGGAAAGTGGGGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26025561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2635	chr1	202780422	202780442	202811294	202811314	74350	hg19					enhancer	enh				GTGCAGATCTGGGGCGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.916767627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2636	chr1	202780426	202780446	202811298	202811318	74351	hg19					enhancer	enh				GAGGCTGCAGATCTGGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.357068631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2637	chr1	202780432	202780452	202811304	202811324	74352	hg19					enhancer	enh				GGGCGAAGGCTGCAGATCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339297481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2638	chr1	202780433	202780453	202811305	202811325	74353	hg19					enhancer	enh				GGGGCGAAGGCTGCAGATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.017527854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2639	chr1	202780446	202780466	202811318	202811338	74354	hg19					enhancer	enh				GCGGGTGTATCTAGGGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238006082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2640	chr1	202780447	202780467	202811319	202811339	74355	hg19					enhancer	enh				GCGCCCCTAGATACACCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040658039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2641	chr1	202780452	202780472	202811324	202811344	74356	hg19					enhancer	enh				GCACCAGGCGGGTGTATCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.268276265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2642	chr1	202780453	202780473	202811325	202811345	74357	hg19					enhancer	enh				GTCACCAGGCGGGTGTATCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.546413565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2643	chr1	202780454	202780474	202811326	202811346	74358	hg19					enhancer	enh				GATCACCAGGCGGGTGTATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.170060607									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2644	chr1	202780455	202780475	202811327	202811347	74359	hg19					enhancer	enh				GATACACCCGCCTGGTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.44874261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2645	chr1	202780464	202780484	202811336	202811356	74360	hg19					enhancer	enh				GGAGCGCCTCATCACCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.079917617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2646	chr1	202780465	202780485	202811337	202811357	74361	hg19					enhancer	enh				GAGGAGCGCCTCATCACCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.482653164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2647	chr1	202780468	202780488	202811340	202811360	74362	hg19					enhancer	enh				GCGAGGAGCGCCTCATCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263370649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2648	chr1	202780476	202780496	202811348	202811368	74363	hg19					enhancer	enh				GGCGCTCCTCGCGTTCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084590337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2649	chr1	202780485	202780505	202811357	202811377	74364	hg19					enhancer	enh				GCGGTTACCGGAAGGAACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.720304489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2650	chr1	202780494	202780514	202811366	202811386	74365	hg19					enhancer	enh				GTTCGCAACGCGGTTACCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041835152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2651	chr1	202780498	202780518	202811370	202811390	74366	hg19					enhancer	enh				GGTCTTCGCAACGCGGTTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221013956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2652	chr1	202780505	202780525	202811377	202811397	74367	hg19					enhancer	enh				GCAGCGTGGTCTTCGCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072400413									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2653	chr1	202780505	202780525	202811377	202811397	74368	hg19					enhancer	enh				GCGTTGCGAAGACCACGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.096047032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2654	chr1	202780506	202780526	202811378	202811398	74369	hg19					enhancer	enh				GTTGCGAAGACCACGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.261944844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2655	chr1	202780518	202780538	202811390	202811410	74370	hg19					enhancer	enh				GACGCTGCCGGGTTGCAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397072128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2656	chr1	202780519	202780539	202811391	202811411	74371	hg19					enhancer	enh				GAAGTTTGCAACCCGGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320511762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2657	chr1	202780519	202780539	202811391	202811411	74372	hg19					enhancer	enh				GCGCTGCCGGGTTGCAAACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.303453914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2658	chr1	202780520	202780540	202811392	202811412	74373	hg19					enhancer	enh				GCTGCCGGGTTGCAAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.51688245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2659	chr1	202780521	202780541	202811393	202811413	74374	hg19					enhancer	enh				GCTGCCGGGTTGCAAACTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15384598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2660	chr1	202780522	202780542	202811394	202811414	74375	hg19					enhancer	enh				GTGCCGGGTTGCAAACTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375373855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2661	chr1	202780527	202780547	202811399	202811419	74376	hg19					enhancer	enh				GTCCCCCCAAGTTTGCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.799434113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2662	chr1	202780560	202780580	202811432	202811452	74377	hg19					enhancer	enh				GTTGCACGGCGCCCAGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284761356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2663	chr1	202780561	202780581	202811433	202811453	74378	hg19					enhancer	enh				GTTGCACGGCGCCCAGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.373913812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2664	chr1	202780564	202780584	202811436	202811456	74379	hg19					enhancer	enh				GCAGTTGCACGGCGCCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130672278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2665	chr1	202780565	202780585	202811437	202811457	74380	hg19					enhancer	enh				GGCAGTTGCACGGCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225392192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2666	chr1	202780566	202780586	202811438	202811458	74381	hg19					enhancer	enh				GGGCAGTTGCACGGCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.550708702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2667	chr1	202780566	202780586	202811438	202811458	74382	hg19					enhancer	enh				GTGGGCGCCGTGCAACTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.042393747									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2668	chr1	202780567	202780587	202811439	202811459	74383	hg19					enhancer	enh				GGGCGCCGTGCAACTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.147066417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2669	chr1	202780567	202780587	202811439	202811459	74384	hg19					enhancer	enh				GAGGGCAGTTGCACGGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102227402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2670	chr1	202780572	202780592	202811444	202811464	74385	hg19					enhancer	enh				GCCGTGCAACTGCCCTGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.32136776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2671	chr1	202780573	202780593	202811445	202811465	74386	hg19					enhancer	enh				GCGTGCAACTGCCCTGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378349346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2672	chr1	202780575	202780595	202811447	202811467	74387	hg19					enhancer	enh				GCCGGTCCCAGGGCAGTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050606666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2673	chr1	202780579	202780599	202811451	202811471	74388	hg19					enhancer	enh				GACTGCCCTGGGACCGGGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.723313605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2674	chr1	202780580	202780600	202811452	202811472	74389	hg19					enhancer	enh				GCTGCCCTGGGACCGGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107253662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2675	chr1	202780586	202780606	202811458	202811478	74390	hg19					enhancer	enh				GCATCCCAGAACCCGGTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.251104526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2676	chr1	202780587	202780607	202811459	202811479	74391	hg19					enhancer	enh				GGGACCGGGTTCTGGGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.204832936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2677	chr1	202780587	202780607	202811459	202811479	74392	hg19					enhancer	enh				GTCATCCCAGAACCCGGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378881684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2678	chr1	202780588	202780608	202811460	202811480	74393	hg19					enhancer	enh				GGACCGGGTTCTGGGATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.078668689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2679	chr1	202780589	202780609	202811461	202811481	74394	hg19					enhancer	enh				GACCGGGTTCTGGGATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.771776638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2680	chr1	202780594	202780614	202811466	202811486	74395	hg19					enhancer	enh				GCCCCCCTCATCCCAGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.535981448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2681	chr1	202780610	202780630	202811482	202811502	74396	hg19					enhancer	enh				GGGCAGACCGGGCTCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.130051003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2682	chr1	202780614	202780634	202811486	202811506	74397	hg19					enhancer	enh				GAGACCGGGCTCCCCAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.293408558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2683	chr1	202780620	202780640	202811492	202811512	74398	hg19					enhancer	enh				GCGCCGGCCGCTGGGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019021388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2684	chr1	202780627	202780647	202811499	202811519	74399	hg19					enhancer	enh				GACGTGCTGCGCCGGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.070234659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2685	chr1	202780628	202780648	202811500	202811520	74400	hg19					enhancer	enh				GTACGTGCTGCGCCGGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.576684046									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2686	chr1	202780629	202780649	202811501	202811521	74401	hg19					enhancer	enh				GCTACGTGCTGCGCCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.210065572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2687	chr1	202780636	202780656	202811508	202811528	74402	hg19					enhancer	enh				GACGTGCGCTACGTGCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.771950875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2688	chr1	202780638	202780658	202811510	202811530	74403	hg19					enhancer	enh				GCAGCACGTAGCGCACGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136035928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2689	chr1	202780639	202780659	202811511	202811531	74404	hg19					enhancer	enh				GCAGCACGTAGCGCACGTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024138365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2690	chr1	202780677	202780697	202811549	202811569	74405	hg19					enhancer	enh				GAAGTTGTCAGAGGCGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.220234189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2691	chr1	202780678	202780698	202811550	202811570	74406	hg19					enhancer	enh				GAAAGTTGTCAGAGGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.37729477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2692	chr1	202780679	202780699	202811551	202811571	74407	hg19					enhancer	enh				GAAAAGTTGTCAGAGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.430675161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2693	chr1	202780684	202780704	202811556	202811576	74408	hg19					enhancer	enh				GCCCTGAAAAGTTGTCAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.339184604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2694	chr1	202780687	202780707	202811559	202811579	74409	hg19					enhancer	enh				GAGCCCTGAAAAGTTGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.211506722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2695	chr1	202780709	202780729	202811581	202811601	74410	hg19					enhancer	enh				GAAGGGAGGCTCACGGACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.370621711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2696	chr1	202780715	202780735	202811587	202811607	74411	hg19					enhancer	enh				GCGTGAGCCTCCCTTCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13821001									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2697	chr1	202780727	202780747	202811599	202811619	74412	hg19					enhancer	enh				GACCGGAGGCCAGGGCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.903532748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2698	chr1	202780735	202780755	202811607	202811627	74413	hg19					enhancer	enh				GAAGGCAGAGACCGGAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.063549247									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2699	chr1	202780736	202780756	202811608	202811628	74414	hg19					enhancer	enh				GCAAGGCAGAGACCGGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.745164274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2700	chr1	202780744	202780764	202811616	202811636	74415	hg19					enhancer	enh				GAGCACGAGCAAGGCAGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.462563422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2701	chr1	202780754	202780774	202811626	202811646	74416	hg19					enhancer	enh				GTGGTGGTAGAAGCACGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.137647307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2702	chr1	202780771	202780791	202811643	202811663	74417	hg19					enhancer	enh				GCCACCCTTCCCCTCCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096726668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2703	chr1	202780774	202780794	202811646	202811666	74418	hg19					enhancer	enh				GCCCTTCCCCTCCCAACCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.09823354									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2704	chr1	202780782	202780802	202811654	202811674	74419	hg19					enhancer	enh				GAGGATCCACCGGGTTGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.508509658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2705	chr1	202780783	202780803	202811655	202811675	74420	hg19					enhancer	enh				GAGGATCCACCGGGTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.089090743									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2706	chr1	202780784	202780804	202811656	202811676	74421	hg19					enhancer	enh				GAGAGGATCCACCGGGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029820057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2707	chr1	202780787	202780807	202811659	202811679	74422	hg19					enhancer	enh				GACGAGAGGATCCACCGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.014604124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2708	chr1	202780788	202780808	202811660	202811680	74423	hg19					enhancer	enh				GACGAGAGGATCCACCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.107550222									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2709	chr1	202780792	202780812	202811664	202811684	74424	hg19					enhancer	enh				GGGAGACGAGAGGATCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0590692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2710	chr1	202780793	202780813	202811665	202811685	74425	hg19					enhancer	enh				GGGGAGACGAGAGGATCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.910021797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2711	chr1	202780812	202780832	202811684	202811704	74426	hg19					enhancer	enh				GCCGGTGCACTGGAGACTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.813517943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2712	chr1	202780813	202780833	202811685	202811705	74427	hg19					enhancer	enh				GAGCCGGTGCACTGGAGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.800829853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2713	chr1	202780814	202780834	202811686	202811706	74428	hg19					enhancer	enh				GAAGCCGGTGCACTGGAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020838752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2714	chr1	202780815	202780835	202811687	202811707	74429	hg19					enhancer	enh				GAAAGCCGGTGCACTGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167763099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2715	chr1	202780822	202780842	202811694	202811714	74430	hg19					enhancer	enh				GACGAGGGAAAGCCGGTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135726616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2716	chr1	202780830	202780850	202811702	202811722	74431	hg19					enhancer	enh				GCGCAGAGGACGAGGGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.556034655									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2717	chr1	202780838	202780858	202811710	202811730	74432	hg19					enhancer	enh				GATGGACTGCGCAGAGGACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.469306245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2718	chr1	202780839	202780859	202811711	202811731	74433	hg19					enhancer	enh				GATGGACTGCGCAGAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.241918223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2719	chr1	202780845	202780865	202811717	202811737	74434	hg19					enhancer	enh				GAGCTGAGATGGACTGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.240952138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2720	chr1	202780857	202780877	202811729	202811749	74435	hg19					enhancer	enh				GATTGGAGAGATGAGCTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.380260205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2721	chr1	202780875	202780895	202811747	202811767	74436	hg19					enhancer	enh				GAGAGATGATGGCATTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153947175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2722	chr1	202780887	202780907	202811759	202811779	74437	hg19					enhancer	enh				GCATCTCTCCTCACCATCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.328322691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2723	chr1	202780895	202780915	202811767	202811787	74438	hg19					enhancer	enh				GCTCACCATCTCTCGGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.031131311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2724	chr1	202780897	202780917	202811769	202811789	74439	hg19					enhancer	enh				GCAGGGCACCGAGAGATGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.039018689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2725	chr1	202780902	202780922	202811774	202811794	74440	hg19					enhancer	enh				GCATTCCAGGGCACCGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103171969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2726	chr1	202780915	202780935	202811787	202811807	74441	hg19					enhancer	enh				GATCTGACAGCAAACATTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.556453798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2727	chr1	202780916	202780936	202811788	202811808	74442	hg19					enhancer	enh				GCATCTGACAGCAAACATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.141373225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2728	chr1	202780940	202780960	202811812	202811832	74443	hg19					enhancer	enh				GAGCGTTTGTGGGTTTCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.468171252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2729	chr1	202780941	202780961	202811813	202811833	74444	hg19					enhancer	enh				GAAGCGTTTGTGGGTTTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.230074511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2730	chr1	202780942	202780962	202811814	202811834	74445	hg19					enhancer	enh				GCAAGCGTTTGTGGGTTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.089093028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2731	chr1	202780947	202780967	202811819	202811839	74446	hg19					enhancer	enh				GACCCACAAACGCTTGCGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.297190599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2732	chr1	202780951	202780971	202811823	202811843	74447	hg19					enhancer	enh				GCCAAATCGCAAGCGTTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.18711503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2733	chr1	202780952	202780972	202811824	202811844	74448	hg19					enhancer	enh				GGCCAAATCGCAAGCGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005994392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2734	chr1	202780973	202780993	202811845	202811865	74449	hg19					enhancer	enh				GCTACACAAAATAAAACAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046971573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2735	chr1	202780976	202780996	202811848	202811868	74450	hg19					enhancer	enh				GGACTACACAAAATAAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.269943705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2736	chr1	202780997	202781017	202811869	202811889	74451	hg19					enhancer	enh				GGGTAGTAACAAGACGTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.131740995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2737	chr1	202781058	202781078	202811930	202811950	74452	hg19					enhancer	enh				GGGAGAGTGCAGGGACACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.487802749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2738	chr1	202781067	202781087	202811939	202811959	74453	hg19					enhancer	enh				GATATGTATGGGGAGAGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.623617716									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2739	chr1	202781068	202781088	202811940	202811960	74454	hg19					enhancer	enh				GAATATGTATGGGGAGAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.032501417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2740	chr1	202781078	202781098	202811950	202811970	74455	hg19					enhancer	enh				GCAGGAGAGGAATATGTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121047077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2741	chr1	202781079	202781099	202811951	202811971	74456	hg19					enhancer	enh				GGCAGGAGAGGAATATGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.725916797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2742	chr1	202781080	202781100	202811952	202811972	74457	hg19					enhancer	enh				GTGGCAGGAGAGGAATATGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.312425724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2743	chr1	202781091	202781111	202811963	202811983	74458	hg19					enhancer	enh				GGCTTACAATCTGGCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.053753304									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2744	chr1	202781096	202781116	202811968	202811988	74459	hg19					enhancer	enh				GCCAGATTGTAAGCCTCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.33893392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2745	chr1	202781096	202781116	202811968	202811988	74460	hg19					enhancer	enh				GCTAGAGGCTTACAATCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087760558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2746	chr1	202781097	202781117	202811969	202811989	74461	hg19					enhancer	enh				GCCAGATTGTAAGCCTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201520371									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2747	chr1	202781100	202781120	202811972	202811992	74462	hg19					enhancer	enh				GCCCTCTAGAGGCTTACAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.258314323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2748	chr1	202781121	202781141	202811993	202812013	74463	hg19					enhancer	enh				GAGAAGTAATGTCTCTCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.392990237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2749	chr1	202781128	202781148	202812000	202812020	74464	hg19					enhancer	enh				GATGTCTCTCTCCTTGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217291283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2750	chr1	202781135	202781155	202812007	202812027	74465	hg19					enhancer	enh				GTCTCCTTGGCACCAGGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.013406489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2751	chr1	202781141	202781161	202812013	202812033	74466	hg19					enhancer	enh				GTGCCACGTGCCTGGTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.298791445									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2752	chr1	202781149	202781169	202812021	202812041	74467	hg19					enhancer	enh				GTGGAGCGTGTGCCACGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286922165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2753	chr1	202781168	202781188	202812040	202812060	74468	hg19					enhancer	enh				GACAAATATTTGTTGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257735786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2754	chr1	202781169	202781189	202812041	202812061	74469	hg19					enhancer	enh				GCAAATATTTGTTGAAAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.185100736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2755	chr1	202781176	202781196	202812048	202812068	74470	hg19					enhancer	enh				GTTGTTGAAAGGGAGGGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.522433912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2756	chr1	202781202	202781222	202812074	202812094	74471	hg19					enhancer	enh				GATGGTAGCCACAGAAACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.523775621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2757	chr1	202781208	202781228	202812080	202812100	74472	hg19					enhancer	enh				GTCTGTGGCTACCATTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136650559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2758	chr1	202781220	202781240	202812092	202812112	74473	hg19					enhancer	enh				GATTGGCTGAGGATGGAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186565952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2759	chr1	202781221	202781241	202812093	202812113	74474	hg19					enhancer	enh				GTTGGCTGAGGATGGAGCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.170314603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2760	chr1	202781221	202781241	202812093	202812113	74475	hg19					enhancer	enh				GAAAGCTCCATCCTCAGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07999807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2761	chr1	202781225	202781245	202812097	202812117	74476	hg19					enhancer	enh				GCTGAGGATGGAGCTTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06426735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2762	chr1	202781241	202781261	202812113	202812133	74477	hg19					enhancer	enh				GGGCTGGACAAAGAAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.524338458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2763	chr1	202781259	202781279	202812131	202812151	74478	hg19					enhancer	enh				GTCTGGTTGACCACATGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.567877298									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2764	chr1	202781263	202781283	202812135	202812155	74479	hg19					enhancer	enh				GTTGACCACATGAAGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.362311346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2765	chr1	202781271	202781291	202812143	202812163	74480	hg19					enhancer	enh				GAGCCTCCTTCCTGCTTCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.168030002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2766	chr1	202781284	202781304	202812156	202812176	74481	hg19					enhancer	enh				GGAGGCTCAGAACGGTGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24641302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2767	chr1	202781285	202781305	202812157	202812177	74482	hg19					enhancer	enh				GAGGCTCAGAACGGTGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.124574349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2768	chr1	202781299	202781319	202812171	202812191	74483	hg19					enhancer	enh				GTGTTGAGGGAGCCTCCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265623699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2769	chr1	202781300	202781320	202812172	202812192	74484	hg19					enhancer	enh				GTTGAGGGAGCCTCCACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.300826058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2770	chr1	202781303	202781323	202812175	202812195	74485	hg19					enhancer	enh				GAGGGAGCCTCCACAATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.481550895									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2771	chr1	202781304	202781324	202812176	202812196	74486	hg19					enhancer	enh				GAGGGAGCCTCCACAATGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.436607989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2772	chr1	202781313	202781333	202812185	202812205	74487	hg19					enhancer	enh				GTGGTGCCCACCCATTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.705941774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2773	chr1	202781313	202781333	202812185	202812205	74488	hg19					enhancer	enh				GCCACAATGGGTGGGCACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225536315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2774	chr1	202781316	202781336	202812188	202812208	74489	hg19					enhancer	enh				GCCTGTGGTGCCCACCCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.071966101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2775	chr1	202781332	202781352	202812204	202812224	74490	hg19					enhancer	enh				GGATGGGTTTATCTCACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261839072									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2776	chr1	202781356	202781376	202812228	202812248	74491	hg19					enhancer	enh				GTTAAGCAGGGCAGGGAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.227951968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2777	chr1	202781357	202781377	202812229	202812249	74492	hg19					enhancer	enh				GATTAAGCAGGGCAGGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.862429604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2778	chr1	202781358	202781378	202812230	202812250	74493	hg19					enhancer	enh				GAATTAAGCAGGGCAGGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.368629725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2779	chr1	202781360	202781380	202812232	202812252	74494	hg19					enhancer	enh				GTCCCTGCCCTGCTTAATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.57005329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2780	chr1	202781361	202781381	202812233	202812253	74495	hg19					enhancer	enh				GCCCTGCCCTGCTTAATTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.35117789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2781	chr1	202781364	202781384	202812236	202812256	74496	hg19					enhancer	enh				GCCCGGGAATTAAGCAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005147018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2782	chr1	202781365	202781385	202812237	202812257	74497	hg19					enhancer	enh				GTCCCGGGAATTAAGCAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.586655884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2783	chr1	202781369	202781389	202812241	202812261	74498	hg19					enhancer	enh				GTGGTTCCCGGGAATTAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.483290219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2784	chr1	202781370	202781390	202812242	202812262	74499	hg19					enhancer	enh				GCTGGTTCCCGGGAATTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.265403152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2785	chr1	202781381	202781401	202812253	202812273	74500	hg19					enhancer	enh				GAGGAGGGGTTGCTGGTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.032273896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2786	chr1	202781382	202781402	202812254	202812274	74501	hg19					enhancer	enh				GTAGGAGGGGTTGCTGGTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103163213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2787	chr1	202781389	202781409	202812261	202812281	74502	hg19					enhancer	enh				GATAGCATAGGAGGGGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107788421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2788	chr1	202781396	202781416	202812268	202812288	74503	hg19					enhancer	enh				GAGTAGACGATAGCATAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.340894846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2789	chr1	202781397	202781417	202812269	202812289	74504	hg19					enhancer	enh				GCAGTAGACGATAGCATAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.222155284									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2790	chr1	202781398	202781418	202812270	202812290	74505	hg19					enhancer	enh				GCAGTAGACGATAGCATAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264344854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2791	chr1	202781401	202781421	202812273	202812293	74506	hg19					enhancer	enh				GTCAGCAGTAGACGATAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051904729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2792	chr1	202781403	202781423	202812275	202812295	74507	hg19					enhancer	enh				GCTATCGTCTACTGCTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.226801489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2793	chr1	202781413	202781433	202812285	202812305	74508	hg19					enhancer	enh				GACTGCTGAGCTGGTCCCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195703303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2794	chr1	202781416	202781436	202812288	202812308	74509	hg19					enhancer	enh				GCTGAGCTGGTCCCTTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037636905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2795	chr1	202781430	202781450	202812302	202812322	74510	hg19					enhancer	enh				GAGCACAGAAGTCCACCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.066713717									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2796	chr1	202781431	202781451	202812303	202812323	74511	hg19					enhancer	enh				GAGCACAGAAGTCCACCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.845627299									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2797	chr1	202781456	202781476	202812328	202812348	74512	hg19					enhancer	enh				GTCTGCTTTAGCCCCAGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153399117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2798	chr1	202781457	202781477	202812329	202812349	74513	hg19					enhancer	enh				GCTGCTTTAGCCCCAGCTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.329937675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2799	chr1	202781458	202781478	202812330	202812350	74514	hg19					enhancer	enh				GTGCTTTAGCCCCAGCTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320086186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2800	chr1	202781468	202781488	202812340	202812360	74515	hg19					enhancer	enh				GCCAGCTGTCGGGGCTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.041159106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2801	chr1	202781469	202781489	202812341	202812361	74516	hg19					enhancer	enh				GAAGGGCAGCCCCGACAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.285045842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2802	chr1	202781469	202781489	202812341	202812361	74517	hg19					enhancer	enh				GCAGCTGTCGGGGCTGCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279326186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2803	chr1	202781470	202781490	202812342	202812362	74518	hg19					enhancer	enh				GAGCTGTCGGGGCTGCCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021140834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2804	chr1	202781470	202781490	202812342	202812362	74519	hg19					enhancer	enh				GCAAGGGCAGCCCCGACAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.766444441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2805	chr1	202781471	202781491	202812343	202812363	74520	hg19					enhancer	enh				GCCAAGGGCAGCCCCGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.655437186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2806	chr1	202781487	202781507	202812359	202812379	74521	hg19					enhancer	enh				GAGGTGTAAGCTGTTCCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195769332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2807	chr1	202781488	202781508	202812360	202812380	74522	hg19					enhancer	enh				GAAGGTGTAAGCTGTTCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.196259608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2808	chr1	202781492	202781512	202812364	202812384	74523	hg19					enhancer	enh				GAACAGCTTACACCTTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.630897976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2809	chr1	202781505	202781525	202812377	202812397	74524	hg19					enhancer	enh				GCTTGACCAGGCGCTCATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043099377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-14400	chr1	202781506	202781526	202812378	202812398	74525	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTGACCAGGCGCTCATTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.1717038	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781507	202781527	202812379	202812399	74526	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCAGAAATGAGCGCCTGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.027028298	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781513	202781533	202812385	202812405	74527	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAAACCCAGAAATGAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119415477	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781534	202781554	202812406	202812426	74528	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTCTTGGGAAGCTGGGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.652087335	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781540	202781560	202812412	202812432	74529	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGGAAGCTGGGTCTGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.001321742	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781541	202781561	202812413	202812433	74530	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGAAGCTGGGTCTGGGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371815743	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781551	202781571	202812423	202812443	74531	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCTGGGTCCTGGGAGCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.994892428	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781561	202781581	202812433	202812453	74532	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTAGTTACCAGGTGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197032985	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781615	202781635	202812487	202812507	74533	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGGGATTCCAGGACAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.188294781	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781620	202781640	202812492	202812512	74534	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCAGAGAGGGATTCCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.132394638	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781625	202781645	202812497	202812517	74535	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGTCATCAGAGAGGGATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.463552776	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781633	202781653	202812505	202812525	74536	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTGGGCTGAGTCATCAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26507427	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781634	202781654	202812506	202812526	74537	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTGGGCTGAGTCATCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.779329239	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781642	202781662	202812514	202812534	74538	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GACTCAGCCCAACTGAGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.635665366	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781643	202781663	202812515	202812535	74539	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCTCAGCCCAACTGAGATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.262154321	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781651	202781671	202812523	202812543	74540	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGTTACCCTGGATCTCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.171050795	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781652	202781672	202812524	202812544	74541	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCAGTTACCCTGGATCTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.080137707	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781663	202781683	202812535	202812555	74542	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GACTGAGGGTGCAGTTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.070715177	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781664	202781684	202812536	202812556	74543	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGTAACTGCACCCTCAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.146898338	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781665	202781685	202812537	202812557	74544	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTAACTGCACCCTCAGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322871537	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781671	202781691	202812543	202812563	74545	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCACCCTCAGTCCTGGGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.192748184	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781677	202781697	202812549	202812569	74546	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAAACCAAAGCCCAGGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.29407227	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781678	202781698	202812550	202812570	74547	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTAAACCAAAGCCCAGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.02207752	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781696	202781716	202812568	202812588	74548	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTACCTGGGTGTGGGGCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.358278799	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781697	202781717	202812569	202812589	74549	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GACCTGGGTGTGGGGCTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.597373789	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781701	202781721	202812573	202812593	74550	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCCTTTGAGCCCCACACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.621044372	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781711	202781731	202812583	202812603	74551	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCTCAAAGGGCTAGACCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.188192019	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781712	202781732	202812584	202812604	74552	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCAAAGGGCTAGACCCTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274512445	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781713	202781733	202812585	202812605	74553	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCAAAGGGCTAGACCCTTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.09974489	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781714	202781734	202812586	202812606	74554	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAAAGGGCTAGACCCTTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.420184598	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781719	202781739	202812591	202812611	74555	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCTAGACCCTTGTGGGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.008813709	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781728	202781748	202812600	202812620	74556	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCAGCGCCTGACCCCCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.068481901	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781729	202781749	202812601	202812621	74557	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCAGCGCCTGACCCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104420722	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781732	202781752	202812604	202812624	74558	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGGGGTCAGGCGCTGACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229427904	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781745	202781765	202812617	202812637	74559	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTGACAAGTGGAACATTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.323875601	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781764	202781784	202812636	202812656	74560	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGCAGGGCTGGCAGCACCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036373927	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781765	202781785	202812637	202812657	74561	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGGCAGGGCTGGCAGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.408355586	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781767	202781787	202812639	202812659	74562	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTGCTGCCAGCCCTGCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.056383899	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781768	202781788	202812640	202812660	74563	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTGCTGCCAGCCCTGCCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.144661055	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781773	202781793	202812645	202812665	74564	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCAGCCCTGCCCACGGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.462830567	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781774	202781794	202812646	202812666	74565	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCAGCCCTGCCCACGGGGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.294663602	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781776	202781796	202812648	202812668	74566	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCAATCCCCGTGGGCAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016816262	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781777	202781797	202812649	202812669	74567	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCCTGCCCACGGGGATTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.848073728	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781778	202781798	202812650	202812670	74568	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCTGCCCACGGGGATTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05522003	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781779	202781799	202812651	202812671	74569	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCTGCCCACGGGGATTGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19186775	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781780	202781800	202812652	202812672	74570	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCTCCCAATCCCCGTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077815447	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781781	202781801	202812653	202812673	74571	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCCCTCCCAATCCCCGTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.354583589	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781785	202781805	202812657	202812677	74572	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTGCCCCTCCCAATCCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.095665083	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781786	202781806	202812658	202812678	74573	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTTGCCCCTCCCAATCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021557325	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781798	202781818	202812670	202812690	74574	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGGGCAAAGTTAGCCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.558933559	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781799	202781819	202812671	202812691	74575	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGGCAAAGTTAGCCACACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.068736782	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781806	202781826	202812678	202812698	74576	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTAGCCACACCAGGGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087055201	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781807	202781827	202812679	202812699	74577	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTAGCCACACCAGGGCTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.657319919	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781819	202781839	202812691	202812711	74578	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGAAACACGCCCTGAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.356556873	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781843	202781863	202812715	202812735	74579	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTCAAGTTGCCCAACTGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002673327	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781844	202781864	202812716	202812736	74580	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCTCAAGTTGCCCAACTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060919435	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781849	202781869	202812721	202812741	74581	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGCTTCTCAAGTTGCCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.069858094	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781850	202781870	202812722	202812742	74582	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTTGGGCAACTTGAGAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.126971117	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781860	202781880	202812732	202812752	74583	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GTGAGAAGCCCTGGACTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275734855	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781870	202781890	202812742	202812762	74584	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GATTGCTCCTTGGGAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.72811392	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781871	202781891	202812743	202812763	74585	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GGATTGCTCCTTGGGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.283799508	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781879	202781899	202812751	202812771	74586	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGCTCACAGGATTGCTCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084495009	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781880	202781900	202812752	202812772	74587	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GCAGCTCACAGGATTGCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.645441694	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781895	202781915	202812767	202812787	74588	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGCTGCTTAGAGAAGCTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057419467	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781903	202781923	202812775	202812795	74589	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGAGAAGCTGTGAGGATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28448679	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-14400	chr1	202781904	202781924	202812776	202812796	74590	hg19	N/A	N/A	fant4353	N/A	enhancer	enh				GAGAAGCTGTGAGGATTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.12165874	KDM5B	chr1	202724494	202808487	3911				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14399
enhrx-lit2810	chr1	202781935	202781955	202812807	202812827	74591	hg19					enhancer	enh				GTTCCCTGTTCATCCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.231992621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2811	chr1	202781941	202781961	202812813	202812833	74592	hg19					enhancer	enh				GTGCCACTGCGGGATGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217098711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2812	chr1	202781942	202781962	202812814	202812834	74593	hg19					enhancer	enh				GGTGCCACTGCGGGATGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.75633181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2813	chr1	202781951	202781971	202812823	202812843	74594	hg19					enhancer	enh				GGTGCTGGTGGTGCCACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.44682632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2814	chr1	202781952	202781972	202812824	202812844	74595	hg19					enhancer	enh				GGGTGCTGGTGGTGCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.413022189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2815	chr1	202781958	202781978	202812830	202812850	74596	hg19					enhancer	enh				GCACCACCAGCACCCCTAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104544283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2816	chr1	202781959	202781979	202812831	202812851	74597	hg19					enhancer	enh				GACCACCAGCACCCCTAATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.631963913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2817	chr1	202781963	202781983	202812835	202812855	74598	hg19					enhancer	enh				GACCCAAATTAGGGGTGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.128912662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2818	chr1	202781966	202781986	202812838	202812858	74599	hg19					enhancer	enh				GAGACCCAAATTAGGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026675426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2819	chr1	202781966	202781986	202812838	202812858	74600	hg19					enhancer	enh				GCACCCCTAATTTGGGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01090951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2820	chr1	202781967	202781987	202812839	202812859	74601	hg19					enhancer	enh				GCACCCCTAATTTGGGTCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200743684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2821	chr1	202781972	202781992	202812844	202812864	74602	hg19					enhancer	enh				GAGCCCAGAGACCCAAATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.003875289									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2822	chr1	202781973	202781993	202812845	202812865	74603	hg19					enhancer	enh				GCAGCCCAGAGACCCAAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191665435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2823	chr1	202781974	202781994	202812846	202812866	74604	hg19					enhancer	enh				GTCAGCCCAGAGACCCAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124728761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2824	chr1	202781974	202781994	202812846	202812866	74605	hg19					enhancer	enh				GAATTTGGGTCTCTGGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.182704019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2825	chr1	202781975	202781995	202812847	202812867	74606	hg19					enhancer	enh				GATTTGGGTCTCTGGGCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.19635769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2826	chr1	202781982	202782002	202812854	202812874	74607	hg19					enhancer	enh				GTCTCTGGGCTGAGGGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.17191669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2827	chr1	202781997	202782017	202812869	202812889	74608	hg19					enhancer	enh				GCCCCTGGCAGCATGCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.35483099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2828	chr1	202782001	202782021	202812873	202812893	74609	hg19					enhancer	enh				GCCATTGAGCATGCTGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092095746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2829	chr1	202782002	202782022	202812874	202812894	74610	hg19					enhancer	enh				GGCCATTGAGCATGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.434710478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2830	chr1	202782003	202782023	202812875	202812895	74611	hg19					enhancer	enh				GGCAGCATGCTCAATGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078392135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2831	chr1	202782003	202782023	202812875	202812895	74612	hg19					enhancer	enh				GAGGCCATTGAGCATGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.630018659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2832	chr1	202782011	202782031	202812883	202812903	74613	hg19					enhancer	enh				GCTCAATGGCCTTGGATAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.065613491									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2833	chr1	202782020	202782040	202812892	202812912	74614	hg19					enhancer	enh				GCCTTGGATAGCTGGAATGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208323896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2834	chr1	202782023	202782043	202812895	202812915	74615	hg19					enhancer	enh				GCCAAACATTCCAGCTATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00830976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2835	chr1	202782051	202782071	202812923	202812943	74616	hg19					enhancer	enh				GAAGACTTTCATCCAAGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.164031359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2836	chr1	202782121	202782141	202812993	202813013	74617	hg19					enhancer	enh				GCAACTGGGAATTTACAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.771207383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2837	chr1	202782124	202782144	202812996	202813016	74618	hg19					enhancer	enh				GTTTCAACTGGGAATTTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.653415062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2838	chr1	202782125	202782145	202812997	202813017	74619	hg19					enhancer	enh				GTGTAAATTCCCAGTTGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416459034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2839	chr1	202782126	202782146	202812998	202813018	74620	hg19					enhancer	enh				GTAAATTCCCAGTTGAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.766909535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2840	chr1	202782133	202782153	202813005	202813025	74621	hg19					enhancer	enh				GCCCAGTTGAAACTGGGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.210290023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2841	chr1	202782136	202782156	202813008	202813028	74622	hg19					enhancer	enh				GCCAAATTCCCAGTTTCAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.071439838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2842	chr1	202782137	202782157	202813009	202813029	74623	hg19					enhancer	enh				GTCCAAATTCCCAGTTTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.017345314									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2843	chr1	202782163	202782183	202813035	202813055	74624	hg19					enhancer	enh				GCAGCATGATTTGGTTGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049329375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2844	chr1	202782173	202782193	202813045	202813065	74625	hg19					enhancer	enh				GCTGGGCACTCAGCATGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.272172851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2845	chr1	202782191	202782211	202813063	202813083	74626	hg19					enhancer	enh				GTAGTGTGTCAGACGCTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.405717345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2846	chr1	202782199	202782219	202813071	202813091	74627	hg19					enhancer	enh				GTCTGACACACTAAATGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136799337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2847	chr1	202782235	202782255	202813107	202813127	74628	hg19					enhancer	enh				GTCCTCTTTCCTGGCAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.234944892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2848	chr1	202782236	202782256	202813108	202813128	74629	hg19					enhancer	enh				GCCTCTTTCCTGGCAGGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.479250092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2849	chr1	202782237	202782257	202813109	202813129	74630	hg19					enhancer	enh				GCTCTTTCCTGGCAGGAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.103764893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2850	chr1	202782239	202782259	202813111	202813131	74631	hg19					enhancer	enh				GCCCGCTTCCTGCCAGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208509804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2851	chr1	202782242	202782262	202813114	202813134	74632	hg19					enhancer	enh				GTCCTGGCAGGAAGCGGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.897337882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2852	chr1	202782243	202782263	202813115	202813135	74633	hg19					enhancer	enh				GCCTGGCAGGAAGCGGGGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.077004033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2853	chr1	202782246	202782266	202813118	202813138	74634	hg19					enhancer	enh				GCCCTATCCCCGCTTCCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.363852179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2854	chr1	202782294	202782314	202813166	202813186	74635	hg19					enhancer	enh				GAATAAGACAAGGCCATTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.887094198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2855	chr1	202782295	202782315	202813167	202813187	74636	hg19					enhancer	enh				GATAAGACAAGGCCATTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.473982332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2856	chr1	202782309	202782329	202813181	202813201	74637	hg19					enhancer	enh				GTATGATTTGCTCCCGGCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.330356408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2857	chr1	202782332	202782352	202813204	202813224	74638	hg19					enhancer	enh				GCATCAGCCCTGTGAAATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286278346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2858	chr1	202782341	202782361	202813213	202813233	74639	hg19					enhancer	enh				GCTAATACCACTCATTTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.329431064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2859	chr1	202782342	202782362	202813214	202813234	74640	hg19					enhancer	enh				GACTAATACCACTCATTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.947722078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2860	chr1	202782422	202782442	202813294	202813314	74641	hg19					enhancer	enh				GCAGACAGTAATAGCAGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.069421565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2861	chr1	202782462	202782482	202813334	202813354	74642	hg19					enhancer	enh				GAAGATCAAAGTTAGGTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.065345352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-14401	chr1	202782550	202782570	202813422	202813442	74643	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GCAGATTAAGGGGCAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.347129694	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782553	202782573	202813425	202813445	74644	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTTGGCAGATTAAGGGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.113806305	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782560	202782580	202813432	202813452	74645	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTTCGATGTTGGCAGATTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.206947003	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782561	202782581	202813433	202813453	74646	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTTCGATGTTGGCAGATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.034031645	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782562	202782582	202813434	202813454	74647	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GGTTCGATGTTGGCAGATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.066658107	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782572	202782592	202813444	202813464	74648	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GGGAGAGAATGGTTCGATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.106099601	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782583	202782603	202813455	202813475	74649	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTAGTCTAGAGGGGAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.676722835	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782585	202782605	202813457	202813477	74650	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GCTCTCCCCTCTAGACTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034043157	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782592	202782612	202813464	202813484	74651	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GAAGCCACTGTAGTCTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.27001098	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782593	202782613	202813465	202813485	74652	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTGAAGCCACTGTAGTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.103874619	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782594	202782614	202813466	202813486	74653	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTTGAAGCCACTGTAGTCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.166024175	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782631	202782651	202813503	202813523	74654	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GTGCTATGTACAAAAAAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.076152364	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782670	202782690	202813542	202813562	74655	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GAAAACAATATTACCTTTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.001565459	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-14401	chr1	202782685	202782705	202813557	202813577	74656	hg19	N/A	N/A	N/A	Enhatls15851	enhancer	enh				GCACCGTGCCTGGCCATACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.190741851	KDM5B	chr1	202724494	202808487	4936				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14400
enhrx-lit2862	chr1	202858135	202858155	202889007	202889027	74657	hg19					enhancer	enh				GCACCCGGGAGCCGCAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.072294769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2863	chr1	202858142	202858164	202889014	202889036	74658	hg19					enhancer	enh				GCTGTGCCAGCGTTGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.078381953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2864	chr1	202858168	202858190	202889040	202889062	74659	hg19					enhancer	enh				GCCGAGGGCCGAAACCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.167038208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2865	chr1	202858175	202858196	202889047	202889068	74660	hg19					enhancer	enh				GTGTCAGCCGAGGGCCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				0.137376918									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2866	chr1	202858185	202858206	202889057	202889078	74661	hg19					enhancer	enh				GAGCGAGTTAGTGTCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	direct	Highly Significant	NA				0.265165621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2867	chr1	202858216	202858236	202889088	202889108	74662	hg19					enhancer	enh				GGCAGCGGCGATGGAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.067223227									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2868	chr1	202858216	202858238	202889088	202889110	74663	hg19					enhancer	enh				GCGGCAGCGGCGATGGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.98710336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2869	chr1	202858231	202858253	202889103	202889125	74664	hg19					enhancer	enh				GCTGAGGAGCCTGTGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.126788408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2870	chr1	202858233	202858255	202889105	202889127	74665	hg19					enhancer	enh				GCCGCCACAGGCTCCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.335841396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2871	chr1	202858237	202858259	202889109	202889131	74666	hg19					enhancer	enh				GCCGTGGCTGAGGAGCCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.668963333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2872	chr1	202858240	202858262	202889112	202889134	74667	hg19					enhancer	enh				GCAGCCGTGGCTGAGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.33227077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2873	chr1	202858249	202858270	202889121	202889142	74668	hg19					enhancer	enh				GCGTCTGCGCAGCCGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	direct	Highly Significant	NA				0.374862827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2874	chr1	202858255	202858276	202889127	202889148	74669	hg19					enhancer	enh				GAGACAGCGTCTGCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				0.087473147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2875	chr1	202858257	202858279	202889129	202889151	74670	hg19					enhancer	enh				GCTGCGCAGACGCTGTCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.276473901									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2876	chr1	202858277	202858299	202889149	202889171	74671	hg19					enhancer	enh				GCTGGCTCGTTATTCACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.149064079									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2877	chr1	202858332	202858354	202889204	202889226	74672	hg19					enhancer	enh				GACGGTCACTATGTCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.251431365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2878	chr1	202858369	202858389	202889241	202889261	74673	hg19					enhancer	enh				GCGCAGTAGAGTCCAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RABIF	indirect	Non Significant	NA				-0.029308688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2879	chr1	203830567	203830587	203861439	203861459	74674	hg19					enhancer	enh				GCCGGTCCTACAGCGCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				0.09689908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2880	chr1	203830589	203830609	203861461	203861481	74675	hg19					enhancer	enh				GCGTCTGCGCTGTGGAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.712212833									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2881	chr1	203830607	203830629	203861479	203861501	74676	hg19					enhancer	enh				GCCTCAGTTTGGCCTCCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-1.526617757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2882	chr1	203830635	203830657	203861507	203861529	74677	hg19					enhancer	enh				GAAGTCACGTTTCTTCGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.351877523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2883	chr1	203830644	203830665	203861516	203861537	74678	hg19					enhancer	enh				GAAACGTGACTTCATGGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.285491678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2884	chr1	203830689	203830710	203861561	203861582	74679	hg19					enhancer	enh				GTGAAGGTCACGCGGCGGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.330919469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2885	chr1	203830690	203830710	203861562	203861582	74680	hg19					enhancer	enh				GTGAAGGTCACGCGGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.413449307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2886	chr1	203830690	203830712	203861562	203861584	74681	hg19					enhancer	enh				GTGTGAAGGTCACGCGGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	direct	Highly Significant	NA				0.433181722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2887	chr1	203830695	203830716	203861567	203861588	74682	hg19					enhancer	enh				GGAAGTGTGAAGGTCACGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	direct	Highly Significant	NA				0.225184124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2888	chr1	203830695	203830715	203861567	203861587	74683	hg19					enhancer	enh				GAAGTGTGAAGGTCACGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.787216105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2889	chr1	203830706	203830727	203861578	203861599	74684	hg19					enhancer	enh				GAACCGGAAGCGGAAGTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				0.014617631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2890	chr1	203830723	203830744	203861595	203861616	74685	hg19					enhancer	enh				GCAACTTCCGGAATAAAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.008790957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2891	chr1	203830788	203830809	203861660	203861681	74686	hg19					enhancer	enh				GACCCTGGCCACGGTACGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-3.507122661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2892	chr1	203830798	203830818	203861670	203861690	74687	hg19					enhancer	enh				GCACTTTCTGACCCTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	direct	Highly Significant	NA				0.353459237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-14538	chr1	203830831	203830852	203861703	203861724	74688	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GCAGCCCATCGTATCCTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.256950295	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-14538	chr1	203830838	203830860	203861710	203861732	74689	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GACATCCTGCGTAGGATACGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.964928698	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-14538	chr1	203830868	203830888	203861740	203861760	74690	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GAGGTTCGGGTCAGAATACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-1.38225792	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-14538	chr1	203830876	203830896	203861748	203861768	74691	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GGTCAGAATACGGGGTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-0.327112637	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-14538	chr1	203830881	203830902	203861753	203861774	74692	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GAATACGGGGTGCGAAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-3.560591151	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-14538	chr1	203830889	203830909	203861761	203861781	74693	hg19	N/A	N/A	N/A	Enhatls16001	enhancer	enh				GGTGCGAAGGCGCAGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRPE	indirect	Non Significant	NA				-1.441683256	SNRPE	chr1	203861598	203871152	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	14537
enhrx-lit2893	chr1	205054158	205054179	205085030	205085051	74694	hg19					enhancer	enh				GATCCTAGTTTATAGAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				-0.248964633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2894	chr1	205054273	205054294	205085145	205085166	74695	hg19					enhancer	enh				GTTCCTAAACTTCCTATAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				-0.216128683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2895	chr1	205054295	205054317	205085167	205085189	74696	hg19					enhancer	enh				GGATTAAGAACTCTGGACTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				0.134365678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2896	chr1	205054296	205054317	205085168	205085189	74697	hg19					enhancer	enh				GATTAAGAACTCTGGACTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	direct	Highly Significant	NA				0.239753616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2897	chr1	205054354	205054375	205085226	205085247	74698	hg19					enhancer	enh				GGAGGTCTTAAGTTACAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				0.036562048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2898	chr1	205054354	205054374	205085226	205085246	74699	hg19					enhancer	enh				GAGGTCTTAAGTTACAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	direct	Highly Significant	NA				0.728678092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2899	chr1	205054368	205054390	205085240	205085262	74700	hg19					enhancer	enh				GACCTCCTTGCCTATCTGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				0.189165723									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2900	chr1	205054376	205054397	205085248	205085269	74701	hg19					enhancer	enh				GTGACCTTCCTCAGATAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				0.146710302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2901	chr1	205054479	205054501	205085351	205085373	74702	hg19					enhancer	enh				GAAATGGAAATTCATAAAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM81	indirect	Non Significant	NA				-0.225135376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-15125	chr1	209796897	209796917	209623552	209623572	74703	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GCCCCAAGCTTGTGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.030021739	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209796965	209796985	209623620	209623640	74704	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GCTCAGGGACAGCCGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-1.813831863	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209796972	209796994	209623627	209623649	74705	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GCTGTCCCTGAGCTGGTCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.524739497	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797005	209797027	209623660	209623682	74706	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GTCGGAGACCTGCTGAGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				0.046581343	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797008	209797028	209623663	209623683	74707	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GGAGACCTGCTGAGCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.312287807	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797016	209797036	209623671	209623691	74708	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GTCAGCCCAGGCTGCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.679005279	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797044	209797064	209623699	209623719	74709	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GGCTGTGCTCAGCATCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				0.03799472	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797136	209797156	209623791	209623811	74710	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GGGCATGGGCACTGCCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.269176141	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797144	209797166	209623799	209623821	74711	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GTGCCCATGCCCGGGGTTATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.036110535	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797150	209797172	209623805	209623827	74712	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GCACCCGGATAACCCCGGGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	direct	Highly Significant	NA				0.769711778	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797156	209797177	209623811	209623832	74713	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GAGGGGCACCCGGATAACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	direct	Highly Significant	NA				0.567227071	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-15125	chr1	209797181	209797202	209623836	209623857	74714	hg19	N/A	enh50168	N/A	N/A	enhancer	enh				GCAGTGCTGATCCTTCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAMB3	indirect	Non Significant	NA				-0.595914647	LAMB3	chr1	209614869	209652425	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	15124
enhrx-lit2902	chr1	212965065	212965085	212791723	212791743	74715	hg19					enhancer	enh				GGTGGTCCTTGACCCTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.159360065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2903	chr1	212965070	212965090	212791728	212791748	74716	hg19					enhancer	enh				GGGTCAAGGACCACCAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-1.788996956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2904	chr1	212965139	212965159	212791797	212791817	74717	hg19					enhancer	enh				GCGGAAAAGCGGGTTCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	direct	Highly Significant	NA				0.748086208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2905	chr1	212965163	212965183	212791821	212791841	74718	hg19					enhancer	enh				GTAACCAGCATGCATCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.500994788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2906	chr1	212965181	212965202	212791839	212791860	74719	hg19					enhancer	enh				GCAGCGTCCTGAGTTTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	direct	Highly Significant	NA				0.588937425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2907	chr1	212965200	212965221	212791858	212791879	74720	hg19					enhancer	enh				GCAGCTGAAACGTTCCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				0.131199944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2908	chr1	212965217	212965239	212791875	212791897	74721	hg19					enhancer	enh				GACCGGCCAGCAGAGCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				0.018156903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2909	chr1	212965222	212965244	212791880	212791902	74722	hg19					enhancer	enh				GGCTCTGCTGGCCGGTCTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.586803082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2910	chr1	212965307	212965327	212791965	212791985	74723	hg19					enhancer	enh				GGTCAAAGTCCGGGGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.977946029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2911	chr1	212965316	212965337	212791974	212791995	74724	hg19					enhancer	enh				GGACTTTGACCGCGTATGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	direct	Highly Significant	NA				0.305576431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2912	chr1	212965317	212965337	212791975	212791995	74725	hg19					enhancer	enh				GACTTTGACCGCGTATGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				0.13999463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2913	chr1	212965323	212965345	212791981	212792003	74726	hg19					enhancer	enh				GACCGCGTATGTGAGGGCGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				0.103931927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2914	chr1	212965333	212965354	212791991	212792012	74727	hg19					enhancer	enh				GTGAGGGCGATACGGGACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.254800489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2915	chr1	212965335	212965355	212791993	212792013	74728	hg19					enhancer	enh				GAGGGCGATACGGGACCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.025492385									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2916	chr1	212965341	212965362	212791999	212792020	74729	hg19					enhancer	enh				GATACGGGACCAGAGGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.209341212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2917	chr1	212965372	212965394	212792030	212792052	74730	hg19					enhancer	enh				GATAACACGAGGGGAAAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.337303351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2918	chr1	212965384	212965404	212792042	212792062	74731	hg19					enhancer	enh				GGAGAGCAAAGATAACACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.145724516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2919	chr1	212965409	212965429	212792067	212792087	74732	hg19					enhancer	enh				GGATATGGGGTTTCGTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.508464728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2920	chr1	212965433	212965453	212792091	212792111	74733	hg19					enhancer	enh				GCCATAAACAAGGGTCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TATDN3	indirect	Non Significant	NA				-0.968704579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2921	chr1	227751134	227751156	227563433	227563455	74734	hg19					enhancer	enh				GCCTCCTTTGGTTATGAGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	direct	Highly Significant	NA				0.853035539									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2922	chr1	227751158	227751179	227563457	227563478	74735	hg19					enhancer	enh				GTCCTGGAGCCCTGTCCAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.105265324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2923	chr1	227751171	227751192	227563470	227563491	74736	hg19					enhancer	enh				GTCCAATCAGGGACATTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				0.092971958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2924	chr1	227751210	227751231	227563509	227563530	74737	hg19					enhancer	enh				GAGCGCAGCTTGAGAGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.106275579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2925	chr1	227751232	227751252	227563531	227563551	74738	hg19					enhancer	enh				GGGGTTTCCGGGATCTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	direct	Highly Significant	NA				0.30350587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2926	chr1	227751242	227751263	227563541	227563562	74739	hg19					enhancer	enh				GACAAAGGCCCCGCCAGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.175131283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2927	chr1	227751253	227751275	227563552	227563574	74740	hg19					enhancer	enh				GGCCTTTGTCTTGTGCTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	direct	Highly Significant	NA				0.593781369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2928	chr1	227751254	227751275	227563553	227563574	74741	hg19					enhancer	enh				GCCTTTGTCTTGTGCTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	direct	Highly Significant	NA				0.331799978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2929	chr1	227751290	227751310	227563589	227563609	74742	hg19					enhancer	enh				GGATAAATAGCCGAGAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.533735831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2930	chr1	227751291	227751311	227563590	227563610	74743	hg19					enhancer	enh				GGGATAAATAGCCGAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.207009272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2931	chr1	227751291	227751312	227563590	227563611	74744	hg19					enhancer	enh				GGGGATAAATAGCCGAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.770947242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2932	chr1	227751298	227751318	227563597	227563617	74745	hg19					enhancer	enh				GGCTATTTATCCCCAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				0.142720082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2933	chr1	227751299	227751321	227563598	227563620	74746	hg19					enhancer	enh				GCTATTTATCCCCAGCTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.268146202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2934	chr1	227751312	227751334	227563611	227563633	74747	hg19					enhancer	enh				GTCACCAGGGCCTCCCGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				0.135391025									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2935	chr1	227751313	227751334	227563612	227563633	74748	hg19					enhancer	enh				GTCACCAGGGCCTCCCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.531297536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2936	chr1	227751348	227751370	227563647	227563669	74749	hg19					enhancer	enh				GTCTGGTTTCCCTGTGACCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.062074411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2937	chr1	227751394	227751416	227563693	227563715	74750	hg19					enhancer	enh				GATGCCAGGACACCCCGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.527715969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2938	chr1	227751402	227751423	227563701	227563722	74751	hg19					enhancer	enh				GACACCCCGAAAGCCGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				-0.055616422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-16182	chr1	227751418	227751440	227563717	227563739	74752	hg19	N/A	N/A	N/A	Enhatls17770	enhancer	enh				GAAAACGGTGAGAGTTCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	indirect	Non Significant	NA				0.072265565	ZNF678	chr1	227563542	227677443	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16181
enhrx-16182	chr1	227751438	227751458	227563737	227563757	74753	hg19	N/A	N/A	N/A	Enhatls17770	enhancer	enh				GCCATCTTGGAACACCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF678	direct	Highly Significant	NA				0.388465422	ZNF678	chr1	227563542	227677443	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16181
enhrx-lit2939	chr1	228353473	228353494	228165772	228165793	74754	hg19					enhancer	enh				GAAGGGCCCAAGGAAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.55280989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2940	chr1	228353474	228353494	228165773	228165793	74755	hg19					enhancer	enh				GAAGGGCCCAAGGAAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-1.713661392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2941	chr1	228353478	228353498	228165777	228165797	74756	hg19					enhancer	enh				GCGGGAAGGGCCCAAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-2.132032829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2942	chr1	228353496	228353518	228165795	228165817	74757	hg19					enhancer	enh				GCTGCCCCACTCTTGTCCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	direct	Highly Significant	NA				0.484389715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2943	chr1	228353505	228353526	228165804	228165825	74758	hg19					enhancer	enh				GGTCGCCATCTTGGACAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.212132001									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2944	chr1	228353505	228353525	228165804	228165824	74759	hg19					enhancer	enh				GTCGCCATCTTGGACAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.326684831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2945	chr1	228353531	228353553	228165830	228165852	74760	hg19					enhancer	enh				GCTGCTTCGAGGCGCCACTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	direct	Highly Significant	NA				0.347518412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2946	chr1	228353531	228353551	228165830	228165850	74761	hg19					enhancer	enh				GCTGCTTCGAGGCGCCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				0.016224316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2947	chr1	228353560	228353580	228165859	228165879	74762	hg19					enhancer	enh				GCGGCCCGGTCTGGCGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.11594011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2948	chr1	228353568	228353589	228165867	228165888	74763	hg19					enhancer	enh				GCGCAGCCGCCAGCGCCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.374662098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2949	chr1	228353587	228353608	228165886	228165907	74764	hg19					enhancer	enh				GCGCGGCCCCAAGGTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				-0.482890639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2950	chr1	228353598	228353619	228165897	228165918	74765	hg19					enhancer	enh				GCTGTGGGCCAGGCGGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IBA57	indirect	Non Significant	NA				0.040526646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-16328	chr1	228675066	228675088	228487365	228487387	74766	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GCCAACGCCGGGGACGCGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	direct	Highly Significant	NA				0.916974471	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675067	228675088	228487366	228487387	74767	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GCCAACGCCGGGGACGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.108731733	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675078	228675098	228487377	228487397	74768	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GGACGAAGACGCCAACGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.391905337	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675094	228675115	228487393	228487414	74769	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GTCCTGTTGCTGGTCTCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.170720558	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675099	228675120	228487398	228487419	74770	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GACCGGACGGAGACCAGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.35028418	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675102	228675122	228487401	228487421	74771	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GCTGGTCTCCGTCCGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.552536462	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675117	228675139	228487416	228487438	74772	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GGAGACCTAGACGGCCGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	direct	Highly Significant	NA				0.458715975	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675117	228675138	228487416	228487437	74773	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GAGACCTAGACGGCCGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				0.068553137	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675124	228675144	228487423	228487443	74774	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GGGCCGGAGACCTAGACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				0.048386619	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675124	228675146	228487423	228487445	74775	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GAGGGCCGGAGACCTAGACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	direct	Highly Significant	NA				0.386000228	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675149	228675169	228487448	228487468	74776	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GCAAGGGCGCAGGAGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.423540276	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-16328	chr1	228675183	228675203	228487482	228487502	74777	hg19	N/A	enh977	N/A	N/A	enhancer	enh				GCAGCCCTGGCGCTCCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF187	indirect	Non Significant	NA				-0.041921767	RNF187	chr1	228487381	228496188	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16327
enhrx-lit2951	chr1	229406837	229406858	229271090	229271111	74778	hg19					enhancer	enh				GGAGATGGGCTACGCGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	indirect	Non Significant	NA				0.037156916									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2952	chr1	229406837	229406857	229271090	229271110	74779	hg19					enhancer	enh				GAGATGGGCTACGCGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.454727153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2953	chr1	229406842	229406863	229271095	229271116	74780	hg19					enhancer	enh				GAAGAGGAGATGGGCTACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.889982486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2954	chr1	229406848	229406870	229271101	229271123	74781	hg19					enhancer	enh				GCCCATCTCCTCTTCCTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.336476382									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2955	chr1	229406859	229406880	229271112	229271133	74782	hg19					enhancer	enh				GCCGCGACCGCGAGGAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	indirect	Non Significant	NA				-1.206003511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2956	chr1	229406865	229406885	229271118	229271138	74783	hg19					enhancer	enh				GTCCGGCCGCGACCGCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	indirect	Non Significant	NA				0.018177737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2957	chr1	229406882	229406904	229271135	229271157	74784	hg19					enhancer	enh				GCAGGGCCCTCCACCCTCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.295139691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2958	chr1	229406890	229406911	229271143	229271164	74785	hg19					enhancer	enh				GTGGAGGGCCCTGCGCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.462983926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2959	chr1	229406897	229406917	229271150	229271170	74786	hg19					enhancer	enh				GCCCTGCGCCTGCGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	direct	Highly Significant	NA				0.857921452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2960	chr1	229406902	229406924	229271155	229271177	74787	hg19					enhancer	enh				GACTCCAGCTCCGCGCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	indirect	Non Significant	NA				-0.126452342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2961	chr1	229406908	229406928	229271161	229271181	74788	hg19					enhancer	enh				GCCGGACTCCAGCTCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB4A	indirect	Non Significant	NA				-0.054322144									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2962	chr1	234745790	234745810	234610044	234610064	74789	hg19					enhancer	enh				GAGAGCGGCGGAGCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-1.39459926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2963	chr1	234745821	234745842	234610075	234610096	74790	hg19					enhancer	enh				GCGCTGGAGAGCGGCGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.284828993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2964	chr1	234745830	234745851	234610084	234610105	74791	hg19					enhancer	enh				GCTCTCCAGCGCCAGCGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.950336266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2965	chr1	234745838	234745859	234610092	234610113	74792	hg19					enhancer	enh				GCTGGCCGCTGACGCTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.574347379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2966	chr1	234745844	234745864	234610098	234610118	74793	hg19					enhancer	enh				GGCGGGCTGGCCGCTGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.548142544									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2967	chr1	234745906	234745928	234610160	234610182	74794	hg19					enhancer	enh				GTCTGTAGAAGTGGAGCGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-2.204832648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2968	chr1	234745917	234745938	234610171	234610192	74795	hg19					enhancer	enh				GAAGAATCAAGTCTGTAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-1.64104495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2969	chr1	234745930	234745950	234610184	234610204	74796	hg19					enhancer	enh				GATTCTTCGACAGTCTCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.236435071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2970	chr1	234745942	234745962	234610196	234610216	74797	hg19					enhancer	enh				GTCTCGCACGGCGCCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				0.126637132									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2971	chr1	234745975	234745995	234610229	234610249	74798	hg19					enhancer	enh				GAGGGCGGGCACGCGCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.094419294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2972	chr1	234746020	234746040	234610274	234610294	74799	hg19					enhancer	enh				GCAGCGCTCCTTCGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	indirect	Non Significant	NA				-0.136759495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2973	chr1	234746035	234746057	234610289	234610311	74800	hg19					enhancer	enh				GCTGCCGGGAGAGCCGGCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	direct	Highly Significant	NA				0.352101983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-16677	chr1	234746100	234746121	234610354	234610375	74801	hg19	N/A	N/A	fant5282	N/A	enhancer	enh				GCGGTGTTCCGAAGGGAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IRF2BP2	direct	Highly Significant	NA				0.519534907	IRF2BP2	chr1	234604268	234610178	165				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	16676
enhrx-lit2974	chr1	236558564	236558586	236395264	236395286	74802	hg19					enhancer	enh				GTACCGGGCAGGACGCGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	direct	Highly Significant	NA				0.978238303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2975	chr1	236558594	236558614	236395294	236395314	74803	hg19					enhancer	enh				GGGGACGCCCGGGACACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				0.107493809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2976	chr1	236558638	236558659	236395338	236395359	74804	hg19					enhancer	enh				GAGCCGGGGTGCCGCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	direct	Highly Significant	NA				0.226499905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2977	chr1	236558668	236558689	236395368	236395389	74805	hg19					enhancer	enh				GCCTCTGGAGGGAGGTACCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	direct	Highly Significant	NA				1.17230048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2978	chr1	236558682	236558703	236395382	236395403	74806	hg19					enhancer	enh				GTACCGAGGGACGCGCAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.506781401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2979	chr1	236558688	236558709	236395388	236395409	74807	hg19					enhancer	enh				GCCCCTTCGCTGCGCGTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.011795088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2980	chr1	236558706	236558727	236395406	236395427	74808	hg19					enhancer	enh				GGCTTTGCTAATTGCCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	direct	Highly Significant	NA				0.407189288									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2981	chr1	236558707	236558727	236395407	236395427	74809	hg19					enhancer	enh				GCTTTGCTAATTGCCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.075547381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2982	chr1	236558719	236558741	236395419	236395441	74810	hg19					enhancer	enh				GCCAAAGCAGGAAGTGAGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				0.111230039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2983	chr1	236558732	236558753	236395432	236395453	74811	hg19					enhancer	enh				GTGAGCTCGTGGAAGAAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	direct	Highly Significant	NA				0.633108971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2984	chr1	236558736	236558756	236395436	236395456	74812	hg19					enhancer	enh				GCTCGTGGAAGAAGCGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-1.658354231									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2985	chr1	236558789	236558809	236395489	236395509	74813	hg19					enhancer	enh				GGCAGGGGCGCGCAGAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				0.170107154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2986	chr1	236558800	236558820	236395500	236395520	74814	hg19					enhancer	enh				GCAGAGCCACGGTTTGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.395045466									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2987	chr1	236558809	236558829	236395509	236395529	74815	hg19					enhancer	enh				GACGCGCCTGGAGCAAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.498332819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2988	chr1	236558815	236558837	236395515	236395537	74816	hg19					enhancer	enh				GCTCCAGGCGCGTCGGAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.121077519									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2989	chr1	236558821	236558842	236395521	236395542	74817	hg19					enhancer	enh				GTCCTGCGGTTCCGACGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				0.155096311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2990	chr1	236558896	236558916	236395596	236395616	74818	hg19					enhancer	enh				GGGCAAACGAGCGTCCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.457924742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2991	chr1	236558908	236558930	236395608	236395630	74819	hg19					enhancer	enh				GTTTGCCCCTAACCCGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EDARADD	indirect	Non Significant	NA				-0.109936125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2992	chr1	246729825	246729846	246566523	246566544	74820	hg19					enhancer	enh				GGCGAGAGGTGTCTCCTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.03913984									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2993	chr1	246729826	246729846	246566524	246566544	74821	hg19					enhancer	enh				GCGAGAGGTGTCTCCTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.080572845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2994	chr1	246729832	246729853	246566530	246566551	74822	hg19					enhancer	enh				GGTGTCTCCTCCACCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.0809533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2995	chr1	246729833	246729853	246566531	246566551	74823	hg19					enhancer	enh				GTGTCTCCTCCACCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				0.074114787									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2996	chr1	246729842	246729863	246566540	246566561	74824	hg19					enhancer	enh				GGTCTCCCCTGGCTCCGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				0.160862869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2997	chr1	246729842	246729862	246566540	246566560	74825	hg19					enhancer	enh				GTCTCCCCTGGCTCCGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.144065605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2998	chr1	246729848	246729868	246566546	246566566	74826	hg19					enhancer	enh				GCTCGGGTCTCCCCTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				0.087853118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit2999	chr1	246729854	246729875	246566552	246566573	74827	hg19					enhancer	enh				GGAGCTTGCTCGGGTCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.142058708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3000	chr1	246729854	246729874	246566552	246566572	74828	hg19					enhancer	enh				GAGCTTGCTCGGGTCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.379700124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3001	chr1	246729864	246729885	246566562	246566583	74829	hg19					enhancer	enh				GTGCTGTCACGGAGCTTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.345985514									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3002	chr1	246729866	246729887	246566564	246566585	74830	hg19					enhancer	enh				GCAAGCTCCGTGACAGCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.420680444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3003	chr1	246729885	246729906	246566583	246566604	74831	hg19					enhancer	enh				GTCGGCCGCCATGTCGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.159915899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3004	chr1	246729885	246729907	246566583	246566605	74832	hg19					enhancer	enh				GTCGGCCGCCATGTCGCCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.174298043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3005	chr1	246729892	246729912	246566590	246566610	74833	hg19					enhancer	enh				GCCATGTCGCCGAGTGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.054424919									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3006	chr1	246729904	246729925	246566602	246566623	74834	hg19					enhancer	enh				GGGTCTGTTTCCAGCCCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.053523002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3007	chr1	246729904	246729924	246566602	246566622	74835	hg19					enhancer	enh				GGTCTGTTTCCAGCCCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.517238082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3008	chr1	246729913	246729934	246566611	246566632	74836	hg19					enhancer	enh				GGAAACAGACCCGGCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.474487695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3009	chr1	246729914	246729934	246566612	246566632	74837	hg19					enhancer	enh				GAAACAGACCCGGCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.621026433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3010	chr1	246729925	246729945	246566623	246566643	74838	hg19					enhancer	enh				GAGGGCTACCGCTGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				0.035963612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3011	chr1	246729932	246729952	246566630	246566650	74839	hg19					enhancer	enh				GCGCAAGGAGGGCTACCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CNST	indirect	Non Significant	NA				-0.133901474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3012	chr1	247267469	247267491	247104167	247104189	74840	hg19					enhancer	enh				GACTGCGCCTGGCTTCCCGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.10898626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3013	chr1	247267482	247267503	247104180	247104201	74841	hg19					enhancer	enh				GAATGGTGAGTGGACTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				0.178319832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3014	chr1	247267514	247267534	247104212	247104232	74842	hg19					enhancer	enh				GGGTGTCCTGGCGTCAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	direct	Highly Significant	NA				0.269266297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3015	chr1	247267523	247267543	247104221	247104241	74843	hg19					enhancer	enh				GGACATCCCTAGCTGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.668897623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3016	chr1	247267569	247267590	247104267	247104288	74844	hg19					enhancer	enh				GAGGCTGCTGCAGAGCCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.046760455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3017	chr1	247267596	247267618	247104294	247104316	74845	hg19					enhancer	enh				GCTGCTAGTTCTTGGCTCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	direct	Highly Significant	NA				0.571003285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3018	chr1	247267607	247267628	247104305	247104326	74846	hg19					enhancer	enh				GAACTAGCAGCGGAGACTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				0.141703106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3019	chr1	247267616	247267637	247104314	247104335	74847	hg19					enhancer	enh				GCGGAGACTAACAGGAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.599429841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3020	chr1	247267621	247267643	247104319	247104341	74848	hg19					enhancer	enh				GACTAACAGGAAGAGCCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	direct	Highly Significant	NA				0.578891579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3021	chr1	247267629	247267649	247104327	247104347	74849	hg19					enhancer	enh				GGAAGAGCCGGCTCCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	direct	Highly Significant	NA				0.24650626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3022	chr1	247267650	247267670	247104348	247104368	74850	hg19					enhancer	enh				GGAGAGACAAAGCAACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.513842989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3023	chr1	247267671	247267691	247104369	247104389	74851	hg19					enhancer	enh				GGCGGCTTCCGGGATCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.358275249									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3024	chr1	247267671	247267692	247104369	247104390	74852	hg19					enhancer	enh				GGGCGGCTTCCGGGATCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.194357842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3025	chr1	247267682	247267704	247104380	247104402	74853	hg19					enhancer	enh				GAAGCCGCCCTCTCCTTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				0.029963973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3026	chr1	247267692	247267712	247104390	247104410	74854	hg19					enhancer	enh				GCGCGCCGCCGGAAAGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.446342517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3027	chr1	247267714	247267734	247104412	247104432	74855	hg19					enhancer	enh				GGGGTGGGGACCGTTCAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.853802418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3028	chr1	247267780	247267801	247104478	247104499	74856	hg19					enhancer	enh				GATCGCAATCTCCTGTCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.297552707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3029	chr1	247267788	247267808	247104486	247104506	74857	hg19					enhancer	enh				GGAGATTGCGATCTCACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF669	indirect	Non Significant	NA				-0.744461856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3030	chr1	247275060	247275081	247111758	247111779	74858	hg19					enhancer	enh				GCTCGCTGGGTCCCTCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-1.829508745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3031	chr1	247275068	247275088	247111766	247111786	74859	hg19					enhancer	enh				GGACCCAGCGAGCCCGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-2.267952281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3032	chr1	247275083	247275103	247111781	247111801	74860	hg19					enhancer	enh				GCAGGACCCCGGCCCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-1.520717555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3033	chr1	247275096	247275117	247111794	247111815	74861	hg19					enhancer	enh				GTCCTGCAGGCGGAGGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.252411828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3034	chr1	247275140	247275161	247111838	247111859	74862	hg19					enhancer	enh				GGAGCAGAAGCAGCGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.205983392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3035	chr1	247275140	247275160	247111838	247111858	74863	hg19					enhancer	enh				GAGCAGAAGCAGCGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				0.034166546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3036	chr1	247275150	247275170	247111848	247111868	74864	hg19					enhancer	enh				GCTTCTGCTCCCGAAGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.528568718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3037	chr1	247275172	247275192	247111870	247111890	74865	hg19					enhancer	enh				GTCGGAGCTGGCGCAGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.011956787									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3038	chr1	247275184	247275204	247111882	247111902	74866	hg19					enhancer	enh				GCAGCGGAGGGTGCGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.178836692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3039	chr1	247275193	247275213	247111891	247111911	74867	hg19					enhancer	enh				GGTGCGGCTCCCGGAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1orf229	indirect	Non Significant	NA				-0.359129706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3040	chr1	247495070	247495091	247331768	247331789	74868	hg19					enhancer	enh				GTGAGTGCACCCCGGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.626584212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3041	chr1	247495075	247495096	247331773	247331794	74869	hg19					enhancer	enh				GCCGGGGTGCACTCACCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.462950867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3042	chr1	247495093	247495114	247331791	247331812	74870	hg19					enhancer	enh				GCCAACAGGGACGCGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				1.157154392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3043	chr1	247495096	247495118	247331794	247331816	74871	hg19					enhancer	enh				GCCCGCCAACAGGGACGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.215128535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3044	chr1	247495097	247495117	247331795	247331815	74872	hg19					enhancer	enh				GGCGCGTCCCTGTTGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.461809834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3045	chr1	247495102	247495123	247331800	247331821	74873	hg19					enhancer	enh				GTCCCTGTTGGCGGGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.59734642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3046	chr1	247495107	247495128	247331805	247331826	74874	hg19					enhancer	enh				GGCCTGCGCCGCCCGCCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				0.051938082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3047	chr1	247495107	247495127	247331805	247331825	74875	hg19					enhancer	enh				GCCTGCGCCGCCCGCCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				0.009838907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3048	chr1	247495108	247495128	247331806	247331826	74876	hg19					enhancer	enh				GGCCTGCGCCGCCCGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.180723042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3049	chr1	247495140	247495162	247331838	247331860	74877	hg19					enhancer	enh				GAGCCCGCCGGACGCCGAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				1.190351003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3050	chr1	247495142	247495162	247331840	247331860	74878	hg19					enhancer	enh				GCCCGCCGGACGCCGAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.417213599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3051	chr1	247495150	247495172	247331848	247331870	74879	hg19					enhancer	enh				GGCCTTTCCTTTCCTCGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				0.116952223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3052	chr1	247495150	247495171	247331848	247331869	74880	hg19					enhancer	enh				GCCTTTCCTTTCCTCGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.744553524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3053	chr1	247495159	247495181	247331857	247331879	74881	hg19					enhancer	enh				GAAAGGAAAGGCCGGAGCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				1.415078722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3054	chr1	247495173	247495195	247331871	247331893	74882	hg19					enhancer	enh				GAGCCCTCCGGCTCCCTCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.003103148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3055	chr1	247495175	247495195	247331873	247331893	74883	hg19					enhancer	enh				GCCCTCCGGCTCCCTCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	direct	Highly Significant	NA				0.467004878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3056	chr1	247495189	247495209	247331887	247331907	74884	hg19					enhancer	enh				GCAGGAAGTGTCCCAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.6650113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3057	chr1	247495194	247495214	247331892	247331912	74885	hg19					enhancer	enh				GCGGAGCAGGAAGTGTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF496	indirect	Non Significant	NA				-0.510758116									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-17545	chr1	249132285	249132305	248838086	248838106	74886	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCCTCGTCCCGCCCAATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	direct	Highly Significant	NA				0.266842634	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132404	249132426	248838205	248838227	74887	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GGCTAAAAGAGAAAGCCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.1953022	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132404	249132425	248838205	248838226	74888	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCTAAAAGAGAAAGCCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.060220769	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132428	249132448	248838229	248838249	74889	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCCTGCTTCCCGGCTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.064749334	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132428	249132449	248838229	248838250	74890	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCCTGCTTCCCGGCTCCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.153224474	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132439	249132459	248838240	248838260	74891	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GGCTCCAGCTGGGGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.380958878	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132464	249132486	248838265	248838287	74892	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GAGTGGTTGGTACGCTGCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.335643969	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132466	249132486	248838267	248838287	74893	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GTGGTTGGTACGCTGCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.188276926	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132488	249132510	248838289	248838311	74894	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCCTCCCAGTCTTCCCAGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.128837616	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132495	249132517	248838296	248838318	74895	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GTCACCGGTTGCTGGGAAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.724969545	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132512	249132533	248838313	248838334	74896	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GTCTGGCGCGGGCAGTGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.068912004	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132524	249132544	248838325	248838345	74897	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCTAGTGGTCAGTCTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.19721218	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132525	249132545	248838326	248838346	74898	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GGCTAGTGGTCAGTCTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.087577848	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132530	249132550	248838331	248838351	74899	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GACTGACCACTAGCCGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.044765835	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132530	249132550	248838331	248838351	74900	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCGTCGGCTAGTGGTCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.352184163	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132567	249132587	248838368	248838388	74901	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCGTGACCTCCCCATCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				0.064921691	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132579	249132599	248838380	248838400	74902	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCGTCCGGCCCCTCGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.408097828	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-17545	chr1	249132620	249132641	248838421	248838442	74903	hg19	N/A	enh1038	N/A	N/A	enhancer	enh				GCGCGCGCGGCCTCCGAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF672	indirect	Non Significant	NA				-0.723501206	ZNF672	chr1	248838223	248849517	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	17544
enhrx-lit3058	chr10	70939881	70939901	69180125	69180145	74904	hg19					enhancer	enh				GAAAGAACACCCTCACGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.318314696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3059	chr10	70939935	70939955	69180179	69180199	74905	hg19					enhancer	enh				GCAGCTTACCTGCTCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.133713412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3060	chr10	70939957	70939978	69180201	69180222	74906	hg19					enhancer	enh				GTCTTTCTGGACAGCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.353552491									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3061	chr10	70940000	70940021	69180244	69180265	74907	hg19					enhancer	enh				GCGCAGCCGCGGACACGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				0.02541037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3062	chr10	70940006	70940026	69180250	69180270	74908	hg19					enhancer	enh				GTCTGGCGCAGCCGCGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.555868927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3063	chr10	70940017	70940039	69180261	69180283	74909	hg19					enhancer	enh				GCGCCAGACAGTGTAGAACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.932337702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3064	chr10	70940019	70940039	69180263	69180283	74910	hg19					enhancer	enh				GCCAGACAGTGTAGAACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-2.399519832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3065	chr10	70940038	70940059	69180282	69180303	74911	hg19					enhancer	enh				GGAGAAGGACATCGAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.358398394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3066	chr10	70940038	70940060	69180282	69180304	74912	hg19					enhancer	enh				GGGAGAAGGACATCGAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.463421985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3067	chr10	70940038	70940058	69180282	69180302	74913	hg19					enhancer	enh				GAGAAGGACATCGAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.002394485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3068	chr10	70940045	70940065	69180289	69180309	74914	hg19					enhancer	enh				GGCACGGGAGAAGGACATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-3.422812549									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3069	chr10	70940045	70940066	69180289	69180310	74915	hg19					enhancer	enh				GGGCACGGGAGAAGGACATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-2.747751759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3070	chr10	70940054	70940076	69180298	69180320	74916	hg19					enhancer	enh				GCCCACAATAGGGCACGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.996310707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3071	chr10	70940061	70940083	69180305	69180327	74917	hg19					enhancer	enh				GAGCCGAGCCCACAATAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.293437883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3072	chr10	70940061	70940081	69180305	69180325	74918	hg19					enhancer	enh				GCCGAGCCCACAATAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.372093689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3073	chr10	70940066	70940088	69180310	69180332	74919	hg19					enhancer	enh				GCCGGGAGCCGAGCCCACAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-3.156238106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3074	chr10	70940067	70940088	69180311	69180332	74920	hg19					enhancer	enh				GCCGGGAGCCGAGCCCACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-1.072950978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3075	chr10	70940086	70940107	69180330	69180351	74921	hg19					enhancer	enh				GTGGCCAGCCTGGCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.156386598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3076	chr10	70940097	70940119	69180341	69180363	74922	hg19					enhancer	enh				GATGGCTGCCCGGTGGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUPV3L1	indirect	Non Significant	NA				-0.354641761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-23055	chr10	102106829	102106850	100347072	100347093	74923	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GCCTCATTAGCATTTCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-1.666898154	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106833	102106854	100347076	100347097	74924	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GCCTCTGGGGAAATGCTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-2.029230878	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106958	102106979	100347201	100347222	74925	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GTCCCGCGTGGAGGTAAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-1.642281679	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106959	102106979	100347202	100347222	74926	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GTCCCGCGTGGAGGTAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-2.145530544	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106962	102106982	100347205	100347225	74927	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GCGGTCCCGCGTGGAGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-2.457743858	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106984	102107005	100347227	100347248	74928	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GTGCGAGGAGTTGACTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-1.554491499	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102106985	102107005	100347228	100347248	74929	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GTGCGAGGAGTTGACTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-0.211480855	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102107001	102107023	100347244	100347266	74930	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GCACTTTGCCCCTGCTTGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-0.198683688	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-23055	chr10	102107014	102107034	100347257	100347277	74931	hg19	N/A	N/A	N/A	Enhatls25309	enhancer	enh				GCTTGGCAGCGGATAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCD	indirect	Non Significant	NA				-2.159624114	SCD	chr10	100347232	100364826	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5490
enhrx-lit3077	chr10	102242322	102242342	100482565	100482585	74932	hg19					enhancer	enh				GCCGAGAGTGCCTAAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				0.296446216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3078	chr10	102242331	102242353	100482574	100482596	74933	hg19					enhancer	enh				GCCTAAGGCGCGGGCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.170647013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3079	chr10	102242352	102242372	100482595	100482615	74934	hg19					enhancer	enh				GCGGCGTTCCCAGCGACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				0.189275419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3080	chr10	102242361	102242381	100482604	100482624	74935	hg19					enhancer	enh				GGGAACGCCGCAGCTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.239890489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3081	chr10	102242383	102242403	100482626	100482646	74936	hg19					enhancer	enh				GCCCGCAGTCCCCGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.03577992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3082	chr10	102242422	102242444	100482665	100482687	74937	hg19					enhancer	enh				GCAGCTGGACACGGTCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				0.380411933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3083	chr10	102242439	102242459	100482682	100482702	74938	hg19					enhancer	enh				GTGGAACTTGCAGTTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				0.815633602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3084	chr10	102242458	102242480	100482701	100482723	74939	hg19					enhancer	enh				GCAGCGGACTGCGCAGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.289342639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3085	chr10	102242471	102242492	100482714	100482735	74940	hg19					enhancer	enh				GTCCGCTGCGAGCAGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.133238449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3086	chr10	102242475	102242496	100482718	100482739	74941	hg19					enhancer	enh				GCTGCGAGCAGTGCCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.082756943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3087	chr10	102242491	102242513	100482734	100482756	74942	hg19					enhancer	enh				GAAGTACTTGGTGACCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				0.122666831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3088	chr10	102242506	102242528	100482749	100482771	74943	hg19					enhancer	enh				GTACTTCTGTAGCCGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				0.152191189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3089	chr10	102242514	102242535	100482757	100482778	74944	hg19					enhancer	enh				GTAGCCGCGCAGAGCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.609927968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3090	chr10	102242538	102242558	100482781	100482801	74945	hg19					enhancer	enh				GGGGCGCTGCGCACAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				1.034566467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3091	chr10	102242591	102242613	100482834	100482856	74946	hg19					enhancer	enh				GCCAAGAACCAGTGGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				-0.712231026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3092	chr10	102242623	102242645	100482866	100482888	74947	hg19					enhancer	enh				GACCCCGGTAATTGTGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				0.290937197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3093	chr10	102242645	102242665	100482888	100482908	74948	hg19					enhancer	enh				GAGCGGGTTCCCCATTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	direct	Highly Significant	NA				0.529900347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3094	chr10	102242655	102242676	100482898	100482919	74949	hg19					enhancer	enh				GAACCCGCTCTCCCAGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WNT8B	indirect	Non Significant	NA				0.009874884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-23361	chr10	104591062	104591082	102831305	102831325	74950	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GTTGGTTGGAAGAAGAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	direct	Highly Significant	NA				0.226592451	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591100	104591121	102831343	102831364	74951	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GAGTTTGGGTAAGTCTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	direct	Highly Significant	NA				0.54444218	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591107	104591127	102831350	102831370	74952	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GGTAAGTCTATGGCAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.527771538	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591118	104591138	102831361	102831381	74953	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GGCAGGATGAGGGTGTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	direct	Highly Significant	NA				0.559309773	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591170	104591192	102831413	102831435	74954	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GCAGCAAGCTTGGCAGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	direct	Highly Significant	NA				0.552376892	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591181	104591202	102831424	102831445	74955	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GGCAGAGGTGAAGGGGTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				0.025047651	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591182	104591202	102831425	102831445	74956	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GCAGAGGTGAAGGGGTACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.78181283	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591222	104591244	102831465	102831487	74957	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GCCCTGGGCCACACAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-1.196706393	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591230	104591251	102831473	102831494	74958	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GTGTGGCCCAGGGCGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-1.685992308	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591239	104591260	102831482	102831503	74959	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GTCTGTCCTGTCCTGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.045601117	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591240	104591262	102831483	102831505	74960	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GAGTCTGTCCTGTCCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.009498531	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-23361	chr10	104591244	104591265	102831487	102831508	74961	hg19	N/A	N/A	N/A	Enhatls25649	enhancer	enh				GCAGGACAGGACAGACTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				0.111576563	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5796
enhrx-lit3095	chr10	104591292	104591314	102831535	102831557	74962	hg19					enhancer	enh				GCTGCATCACAATGAGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.589643978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3096	chr10	104591297	104591317	102831540	102831560	74963	hg19					enhancer	enh				GGCGCTGCATCACAATGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				0.063281764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-23362	chr10	104591351	104591372	102831594	102831615	74964	hg19	N/A	N/A	N/A	Enhatls25650	enhancer	enh				GCAGCATCGGTGAGTTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	direct	Highly Significant	NA				0.331513665	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5797
enhrx-23362	chr10	104591364	104591385	102831607	102831628	74965	hg19	N/A	N/A	N/A	Enhatls25650	enhancer	enh				GATGCTGCTCCAGAGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CYP17A1	indirect	Non Significant	NA				-0.942465247	CYP17A1	chr10	102830530	102837472	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5797
enhrx-lit3097	chr10	105156390	105156410	103396633	103396653	74966	hg19					enhancer	enh				GGAAGAATTGCACTGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	direct	Highly Significant	NA				0.233014705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3098	chr10	105156399	105156419	103396642	103396662	74967	hg19					enhancer	enh				GCACTGGACTGTGGGTATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.236840361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3099	chr10	105156420	105156441	103396663	103396684	74968	hg19					enhancer	enh				GTACTCACACACGCGGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-2.140808544									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3100	chr10	105156421	105156443	103396664	103396686	74969	hg19					enhancer	enh				GTCTCCGCGTGTGTGAGTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-2.665108321									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3101	chr10	105156428	105156449	103396671	103396692	74970	hg19					enhancer	enh				GCGCCGCGGTACTCACACACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-0.867420356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3102	chr10	105156429	105156450	103396672	103396693	74971	hg19					enhancer	enh				GTGTGTGAGTACCGCGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.920443466									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3103	chr10	105156443	105156464	103396686	103396707	74972	hg19					enhancer	enh				GCTACCACTAACCTCGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-0.495930525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3104	chr10	105156444	105156464	103396687	103396707	74973	hg19					enhancer	enh				GGCGCGAGGTTAGTGGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.363271707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3105	chr10	105156458	105156479	103396701	103396722	74974	hg19					enhancer	enh				GGTAGCTGGGTGCAGACGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-2.297711535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3106	chr10	105156459	105156479	103396702	103396722	74975	hg19					enhancer	enh				GTAGCTGGGTGCAGACGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-3.338036285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3107	chr10	105156465	105156485	103396708	103396728	74976	hg19					enhancer	enh				GGGTGCAGACGCCGTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.863447418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3108	chr10	105156475	105156495	103396718	103396738	74977	hg19					enhancer	enh				GCCGTGGCGCTGGTGAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-3.797530049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3109	chr10	105156479	105156499	103396722	103396742	74978	hg19					enhancer	enh				GCCTTTACTCACCAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.933838635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3110	chr10	105156481	105156501	103396724	103396744	74979	hg19					enhancer	enh				GCGCTGGTGAGTAAAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-3.305242551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3111	chr10	105156489	105156510	103396732	103396753	74980	hg19					enhancer	enh				GAGTAAAGGCAGAGGCGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-1.782637836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3112	chr10	105156522	105156542	103396765	103396785	74981	hg19					enhancer	enh				GGACAGACCTGACAGCCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD11	indirect	Non Significant	NA				-6.876686764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3113	chr10	112327372	112327393	110567614	110567635	74982	hg19					enhancer	enh				GACTCCTCCTACGCCCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-0.274503185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3114	chr10	112327379	112327400	110567621	110567642	74983	hg19					enhancer	enh				GCAGCCTTCACAGGGCGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-0.544499695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3115	chr10	112327395	112327416	110567637	110567658	74984	hg19					enhancer	enh				GCTGCAAGGTGGTTCCGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	direct	Highly Significant	NA				0.42043584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3116	chr10	112327412	112327432	110567654	110567674	74985	hg19					enhancer	enh				GGCGGAGTCCGCGCCTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	direct	Highly Significant	NA				0.200378179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3117	chr10	112327412	112327433	110567654	110567675	74986	hg19					enhancer	enh				GGGCGGAGTCCGCGCCTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				0.079389933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3118	chr10	112327448	112327469	110567690	110567711	74987	hg19					enhancer	enh				GCTCCCCTCAGCCAAACAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	direct	Highly Significant	NA				0.265420122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3119	chr10	112327495	112327517	110567737	110567759	74988	hg19					enhancer	enh				GTAGGCGCCTCACCTGACCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-1.394449909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3120	chr10	112327505	112327526	110567747	110567768	74989	hg19					enhancer	enh				GCACGGCCGCAGGGTCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-2.000424553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3121	chr10	112327510	112327532	110567752	110567774	74990	hg19					enhancer	enh				GCAACCGCACGGCCGCAGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-0.93633274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3122	chr10	112327515	112327535	110567757	110567777	74991	hg19					enhancer	enh				GCAGCAACCGCACGGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-1.596359616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3123	chr10	112327516	112327537	110567758	110567779	74992	hg19					enhancer	enh				GAGCAGCAACCGCACGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-0.736068967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3124	chr10	112327522	112327543	110567764	110567785	74993	hg19					enhancer	enh				GTGCGGTTGCTGCTCCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-1.95358578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3125	chr10	112327523	112327543	110567765	110567785	74994	hg19					enhancer	enh				GCCCCGGAGCAGCAACCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-2.638086862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3126	chr10	112327539	112327559	110567781	110567801	74995	hg19					enhancer	enh				GCCTGGAAGGAGACCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-1.764029128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3127	chr10	112327545	112327567	110567787	110567809	74996	hg19					enhancer	enh				GTCTCCTTCCAGGCCAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				0.146737106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-23740	chr10	112327602	112327624	110567844	110567866	74997	hg19	N/A	N/A	N/A	Enhatls26060	enhancer	enh				GTCCCTCCACCCCGTCATGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-0.217916181	SMC3	chr10	110567694	110606048	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6175
enhrx-23740	chr10	112327614	112327634	110567856	110567876	74998	hg19	N/A	N/A	N/A	Enhatls26060	enhancer	enh				GCCCTTACCGGCCCATGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-2.180206393	SMC3	chr10	110567694	110606048	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6175
enhrx-23740	chr10	112327626	112327646	110567868	110567888	74999	hg19	N/A	N/A	N/A	Enhatls26060	enhancer	enh				GTAAGGGCCGCTCCTTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC3	indirect	Non Significant	NA				-1.794406886	SMC3	chr10	110567694	110606048	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6175
enhrx-lit3128	chr11	60673866	60673887	60906394	60906415	75000	hg19					enhancer	enh				GTGCTCCGAGGCGCCACACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-2.066693374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3129	chr11	60673947	60673967	60906475	60906495	75001	hg19					enhancer	enh				GGACTGCTCCGCGGCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-1.159273993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3130	chr11	60673958	60673980	60906486	60906508	75002	hg19					enhancer	enh				GCTGGCGGCTCCCAGCTCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.0308883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3131	chr11	60673978	60673999	60906506	60906527	75003	hg19					enhancer	enh				GCTACGCTAGCATCGCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-1.026989447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3132	chr11	60673982	60674004	60906510	60906532	75004	hg19					enhancer	enh				GAAGCGCTACGCTAGCATCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-2.266848289									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3133	chr11	60673985	60674007	60906513	60906535	75005	hg19					enhancer	enh				GATGCTAGCGTAGCGCTTCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-1.285220153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3134	chr11	60673988	60674008	60906516	60906536	75006	hg19					enhancer	enh				GCTAGCGTAGCGCTTCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-5.332917771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3135	chr11	60673994	60674015	60906522	60906543	75007	hg19					enhancer	enh				GTAGCGCTTCACGTGGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-2.33230242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3136	chr11	60673994	60674014	60906522	60906542	75008	hg19					enhancer	enh				GTAGCGCTTCACGTGGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-2.537936582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3137	chr11	60674025	60674045	60906553	60906573	75009	hg19					enhancer	enh				GTGCTGAAGGCTGTGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-2.312010379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3138	chr11	60674038	60674060	60906566	60906588	75010	hg19					enhancer	enh				GGCAATTTCCGTTAGGTGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	direct	Highly Significant	NA				0.252102992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3139	chr11	60674038	60674059	60906566	60906587	75011	hg19					enhancer	enh				GCAATTTCCGTTAGGTGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				0.100678258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3140	chr11	60674057	60674078	60906585	60906606	75012	hg19					enhancer	enh				GCCCTTTCCCAGAATGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.356397631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3141	chr11	60674057	60674077	60906585	60906605	75013	hg19					enhancer	enh				GCCCTTTCCCAGAATGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	direct	Highly Significant	NA				0.557543081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3142	chr11	60674062	60674082	60906590	60906610	75014	hg19					enhancer	enh				GCCCGGCTGCATTCTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.78466081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3143	chr11	60674068	60674088	60906596	60906616	75015	hg19					enhancer	enh				GAATGCAGCCGGGCAGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.54216969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3144	chr11	60674079	60674099	60906607	60906627	75016	hg19					enhancer	enh				GTGGCGGGCCCTTTCCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.645926479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3145	chr11	60674084	60674106	60906612	60906634	75017	hg19					enhancer	enh				GAAAGGGCCCGCCACGAACACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	direct	Highly Significant	NA				0.252239487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3146	chr11	60674128	60674149	60906656	60906677	75018	hg19					enhancer	enh				GCTCGTTCCGTAAAGCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRPF19	indirect	Non Significant	NA				-0.439111316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3147	chr11	118023575	118023595	118152860	118152880	75019	hg19					enhancer	enh				GCTCGCCCGCTGCTGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				-1.005482929									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3148	chr11	118023593	118023613	118152878	118152898	75020	hg19					enhancer	enh				GCCGGCTGCTGGAGCAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				0.031145561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3149	chr11	118023651	118023673	118152936	118152958	75021	hg19					enhancer	enh				GAGGAAGACGGAGCGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	direct	Highly Significant	NA				0.465764926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3150	chr11	118023653	118023673	118152938	118152958	75022	hg19					enhancer	enh				GGAAGACGGAGCGAGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				-0.276069201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3151	chr11	118023661	118023682	118152946	118152967	75023	hg19					enhancer	enh				GAGCGAGCGCAGCGGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				0.058193023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3152	chr11	118023677	118023699	118152962	118152984	75024	hg19					enhancer	enh				GAGCGAGGCTGCGCCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				0.199159833									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3153	chr11	118023693	118023714	118152978	118152999	75025	hg19					enhancer	enh				GCTGGAGCGCTTCCAGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	direct	Highly Significant	NA				0.705275951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3154	chr11	118023695	118023717	118152980	118153002	75026	hg19					enhancer	enh				GCTCTGGAAGCGCTCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				0.094353174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3155	chr11	118023700	118023721	118152985	118153006	75027	hg19					enhancer	enh				GGAAGCGCTCCAGCCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				-0.269323459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3156	chr11	118023701	118023721	118152986	118153006	75028	hg19					enhancer	enh				GAAGCGCTCCAGCCGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				0.138932376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3157	chr11	118023706	118023728	118152991	118153013	75029	hg19					enhancer	enh				GCTCCAGCCGCAGGAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				-0.060439384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3158	chr11	118023712	118023732	118152997	118153017	75030	hg19					enhancer	enh				GCCACCGCCCCTCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCN4B	indirect	Non Significant	NA				-0.092977645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-33537	chr11	118179052	118179073	118308337	118308358	75031	hg19	N/A	N/A	N/A	Enhatls36393	enhancer	enh				GAGGGAAGAGTCCCAACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	indirect	Non Significant	NA				-0.01700538	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8206
enhrx-33537	chr11	118179059	118179079	118308344	118308364	75032	hg19	N/A	N/A	N/A	Enhatls36393	enhancer	enh				GAGTCCCAACCCACGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	direct	Highly Significant	NA				0.238239619	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8206
enhrx-33537	chr11	118179071	118179093	118308356	118308378	75033	hg19	N/A	N/A	N/A	Enhatls36393	enhancer	enh				GAAGATCAGACCCTGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	indirect	Non Significant	NA				0.135859478	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8206
enhrx-33537	chr11	118179096	118179116	118308381	118308401	75034	hg19	N/A	N/A	N/A	Enhatls36393	enhancer	enh				GCCGATAGAAACATTACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	indirect	Non Significant	NA				0.158466819	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8206
enhrx-33538	chr11	118179260	118179282	118308545	118308567	75035	hg19	N/A	N/A	N/A	Enhatls36394	enhancer	enh				GGAAAATACAAGTATCTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	direct	Highly Significant	NA				0.231616122	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8207
enhrx-33538	chr11	118179261	118179283	118308546	118308568	75036	hg19	N/A	N/A	N/A	Enhatls36394	enhancer	enh				GAAAATACAAGTATCTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	direct	Highly Significant	NA				0.352013161	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8207
enhrx-33538	chr11	118179350	118179371	118308635	118308656	75037	hg19	N/A	N/A	N/A	Enhatls36394	enhancer	enh				GTATCTCTGATCATACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CD3E	indirect	Non Significant	NA				-0.359662384	CD3E	chr11	118304729	118316173	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8207
enhrx-lit3159	chr11	123756468	123756489	123885761	123885782	75038	hg19					enhancer	enh				GTAGAAAGAGCTGTCACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.523788745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3160	chr11	123756515	123756536	123885808	123885829	75039	hg19					enhancer	enh				GTTAGACGTGCATGACTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.106698372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3161	chr11	123756543	123756564	123885836	123885857	75040	hg19					enhancer	enh				GTGTAATTCTAACTCCTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.071889651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3162	chr11	123756636	123756658	123885929	123885951	75041	hg19					enhancer	enh				GTTAGCTAGCTAGTATCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				0.091244877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3163	chr11	123756692	123756713	123885985	123886006	75042	hg19					enhancer	enh				GAAATGTGTGTTCCCATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.296227694									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3164	chr11	123756720	123756742	123886013	123886035	75043	hg19					enhancer	enh				GACTCCCTAACTAAATGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.716894784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3165	chr11	123756808	123756830	123886101	123886123	75044	hg19					enhancer	enh				GCCCAATCTCATTTATAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	indirect	Non Significant	NA				-0.238026627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3166	chr11	123756813	123756835	123886106	123886128	75045	hg19					enhancer	enh				GTCCATGCCTTATAAATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM225	direct	Highly Significant	NA				0.416860336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3167	chr12	6677371	6677391	6568205	6568225	75046	hg19					enhancer	enh				GACATTAACCCGCATTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-0.953581676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3168	chr12	6677388	6677408	6568222	6568242	75047	hg19					enhancer	enh				GTCCGAGAGTGCCCTTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.140798583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3169	chr12	6677402	6677423	6568236	6568257	75048	hg19					enhancer	enh				GCACGTGGAGGGCCGCCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.221570828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3170	chr12	6677403	6677423	6568237	6568257	75049	hg19					enhancer	enh				GCACGTGGAGGGCCGCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.302853243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3171	chr12	6677406	6677427	6568240	6568261	75050	hg19					enhancer	enh				GGCGGCCCTCCACGTGCAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-4.023323641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3172	chr12	6677407	6677427	6568241	6568261	75051	hg19					enhancer	enh				GCGGCCCTCCACGTGCAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-3.313716447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3173	chr12	6677415	6677437	6568249	6568271	75052	hg19					enhancer	enh				GCTAGGTCCGGATTGCACGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-3.69327975									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3174	chr12	6677429	6677450	6568263	6568284	75053	hg19					enhancer	enh				GTGCCGGCCGAAAGCTAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-3.086327867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3175	chr12	6677434	6677455	6568268	6568289	75054	hg19					enhancer	enh				GGCGAGTGCCGGCCGAAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-5.026838564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3176	chr12	6677434	6677454	6568268	6568288	75055	hg19					enhancer	enh				GCGAGTGCCGGCCGAAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-6.330262397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3177	chr12	6677446	6677468	6568280	6568302	75056	hg19					enhancer	enh				GGAACGATTCTGTGGCGAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-1.529381971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3178	chr12	6677446	6677467	6568280	6568301	75057	hg19					enhancer	enh				GAACGATTCTGTGGCGAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-1.999853861									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3179	chr12	6677452	6677472	6568286	6568306	75058	hg19					enhancer	enh				GCCACAGAATCGTTCCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.626136149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3180	chr12	6677458	6677480	6568292	6568314	75059	hg19					enhancer	enh				GAATCGTTCCACGCAGGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.615142379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3181	chr12	6677458	6677479	6568292	6568313	75060	hg19					enhancer	enh				GAATCGTTCCACGCAGGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-0.843477428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3182	chr12	6677469	6677489	6568303	6568323	75061	hg19					enhancer	enh				GCGCTACCCGTGCGCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.387373877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3183	chr12	6677476	6677497	6568310	6568331	75062	hg19					enhancer	enh				GCACGGGTAGCGCTAGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-0.033740274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3184	chr12	6677514	6677534	6568348	6568368	75063	hg19					enhancer	enh				GGCGGCCGACTAGGCGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-0.793852907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3185	chr12	6677519	6677539	6568353	6568373	75064	hg19					enhancer	enh				GCCTAGTCGGCCGCCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-1.550823804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3186	chr12	6677605	6677626	6568439	6568460	75065	hg19					enhancer	enh				GAGACGCGCAGCTTACACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP2	indirect	Non Significant	NA				-2.265231138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3187	chr12	8333020	8333042	8180424	8180446	75066	hg19					enhancer	enh				GCCTGAGGCCGGATACCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				0.001255418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3188	chr12	8333027	8333048	8180431	8180452	75067	hg19					enhancer	enh				GCCGGATACCCACTCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				0.026512132									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3189	chr12	8333038	8333059	8180442	8180463	75068	hg19					enhancer	enh				GCGGGTATCCGAGCCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-0.30591806									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3190	chr12	8333045	8333067	8180449	8180471	75069	hg19					enhancer	enh				GCTCGGATACCCGCGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				0.107980731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3191	chr12	8333057	8333077	8180461	8180481	75070	hg19					enhancer	enh				GGATGCTCCGGGCCCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-1.416837382									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3192	chr12	8333127	8333149	8180531	8180553	75071	hg19					enhancer	enh				GCCCCGGCTCCGCGAGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-0.242586174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3193	chr12	8333133	8333153	8180537	8180557	75072	hg19					enhancer	enh				GCCGCCTCTTCTCGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-0.012290968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3194	chr12	8333138	8333158	8180542	8180562	75073	hg19					enhancer	enh				GCGAGAAGAGGCGGCAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				0.088431347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3195	chr12	8333239	8333260	8180643	8180664	75074	hg19					enhancer	enh				GTTCTGGTGTAGGTGGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-0.242208343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3196	chr12	8333244	8333264	8180648	8180668	75075	hg19					enhancer	enh				GGTGTAGGTGGATCCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	indirect	Non Significant	NA				-0.232730024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3197	chr12	8333261	8333281	8180665	8180685	75076	hg19					enhancer	enh				GTCTTGGTCCTGAGCCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF705A	direct	Highly Significant	NA				0.32686021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3198	chr13	28196002	28196024	27621865	27621887	75077	hg19					enhancer	enh				GTCCTCCGCGCCTTCCGTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.109738562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3199	chr13	28196007	28196029	27621870	27621892	75078	hg19					enhancer	enh				GACCGACCGACGGAAGGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.611220668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3200	chr13	28196010	28196030	27621873	27621893	75079	hg19					enhancer	enh				GGACCGACCGACGGAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-1.788994957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3201	chr13	28196015	28196037	27621878	27621900	75080	hg19					enhancer	enh				GAAGCAAGGACCGACCGACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-6.205534793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3202	chr13	28196019	28196041	27621882	27621904	75081	hg19					enhancer	enh				GCAGGAAGCAAGGACCGACCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-1.915770633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3203	chr13	28196048	28196069	27621911	27621932	75082	hg19					enhancer	enh				GTCCCATAGCGCGAGGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.307444329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3204	chr13	28196056	28196076	27621919	27621939	75083	hg19					enhancer	enh				GGGCTCTGTCCCATAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.241924845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3205	chr13	28196056	28196077	27621919	27621940	75084	hg19					enhancer	enh				GGGGCTCTGTCCCATAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-1.774510804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3206	chr13	28196084	28196104	27621947	27621967	75085	hg19					enhancer	enh				GGATCCTCAGGTGGTGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.742176387									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3207	chr13	28196093	28196113	27621956	27621976	75086	hg19					enhancer	enh				GCGGTTTCTGGATCCTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.395644242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3208	chr13	28196099	28196121	27621962	27621984	75087	hg19					enhancer	enh				GATCCAGAAACCGCCCCAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-1.00380959									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3209	chr13	28196105	28196127	27621968	27621990	75088	hg19					enhancer	enh				GAAACCGCCCCAGCGATGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-2.216440008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3210	chr13	28196112	28196133	27621975	27621996	75089	hg19					enhancer	enh				GATCCTCTTCCATCGCTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-0.871140559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3211	chr13	28196117	28196139	27621980	27622002	75090	hg19					enhancer	enh				GCTCCTGATCCTCTTCCATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1D	indirect	Non Significant	NA				-0.216511639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-47532	chr13	103704885	103704905	103052535	103052555	75091	hg19	N/A	N/A	N/A	Enhatls51322	enhancer	enh				GAATGAAACCATTTCATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	direct	Highly Significant	NA				0.312374625	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3154
enhrx-47532	chr13	103704937	103704957	103052587	103052607	75092	hg19	N/A	N/A	N/A	Enhatls51322	enhancer	enh				GAATATTTAATGGTGTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-2.149470209	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3154
enhrx-lit3212	chr13	103704999	103705020	103052649	103052670	75093	hg19					enhancer	enh				GGAATGTTTGTTAATCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.288501423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3213	chr13	103704999	103705019	103052649	103052669	75094	hg19					enhancer	enh				GAATGTTTGTTAATCACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.007972915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3214	chr13	103705002	103705022	103052652	103052672	75095	hg19					enhancer	enh				GTGATTAACAAACATTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	direct	Highly Significant	NA				0.678430184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-47533	chr13	103705051	103705072	103052701	103052722	75096	hg19	N/A	N/A	N/A	Enhatls51323	enhancer	enh				GATGTACCTAAAGATGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.08974275	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3155
enhrx-47533	chr13	103705073	103705094	103052723	103052744	75097	hg19	N/A	N/A	N/A	Enhatls51323	enhancer	enh				GGGCAATGTGATCAGCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.244654346	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3155
enhrx-47533	chr13	103705074	103705094	103052724	103052744	75098	hg19	N/A	N/A	N/A	Enhatls51323	enhancer	enh				GGCAATGTGATCAGCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.195003171	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3155
enhrx-47533	chr13	103705082	103705103	103052732	103052753	75099	hg19	N/A	N/A	N/A	Enhatls51323	enhancer	enh				GATCAGCAGAACAGGTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	indirect	Non Significant	NA				-0.679295445	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3155
enhrx-47533	chr13	103705128	103705149	103052778	103052799	75100	hg19	N/A	N/A	N/A	Enhatls51323	enhancer	enh				GCAGCCTGAAGAAAGATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC10A2	direct	Highly Significant	NA				0.329532393	SLC10A2	chr13	103043997	103066417	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3155
enhrx-lit3215	chr13	115000410	115000432	114234935	114234957	75101	hg19					enhancer	enh				GGACCTGCGGCCTTCGAGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-0.426632317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3216	chr13	115000411	115000432	114234936	114234957	75102	hg19					enhancer	enh				GACCTGCGGCCTTCGAGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-2.14558967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3217	chr13	115000416	115000437	114234941	114234962	75103	hg19					enhancer	enh				GGCCGCGGACTCGAAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-0.84730826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3218	chr13	115000416	115000436	114234941	114234961	75104	hg19					enhancer	enh				GCCGCGGACTCGAAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-1.702282176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3219	chr13	115000423	115000445	114234948	114234970	75105	hg19					enhancer	enh				GACTCGAAGGCCGCGGACTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-4.611647426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3220	chr13	115000425	115000446	114234950	114234971	75106	hg19					enhancer	enh				GAGTCCGCGGCCTTCGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-6.834598399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3221	chr13	115000432	115000452	114234957	114234977	75107	hg19					enhancer	enh				GCCCCAGGACTCGAAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-2.181895661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3222	chr13	115000434	115000454	114234959	114234979	75108	hg19					enhancer	enh				GCCTTCGAGTCCTGGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-2.517023243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3223	chr13	115000438	115000458	114234963	114234983	75109	hg19					enhancer	enh				GCCGCCGCCCCAGGACTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-1.86575307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3224	chr13	115000462	115000484	114234987	114235009	75110	hg19					enhancer	enh				GCTGCAGGCACGGGCACGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-0.136784285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3225	chr13	115000502	115000523	114235027	114235048	75111	hg19					enhancer	enh				GTGCAGGAGGCGCGCGCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-3.034742156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3226	chr13	115000513	115000533	114235038	114235058	75112	hg19					enhancer	enh				GCGCGCCTAGCGGCGGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CDC16	indirect	Non Significant	NA				-1.050339773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3227	chr14	64854874	64854896	64388156	64388178	75113	hg19					enhancer	enh				GATGAAGAAAATCGGTGATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-0.158019501									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3228	chr14	64854918	64854939	64388200	64388221	75114	hg19					enhancer	enh				GAGCTAACAGGTCGGGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-0.409662168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3229	chr14	64854935	64854957	64388217	64388239	75115	hg19					enhancer	enh				GCTCTCGGTTAGTTAAGGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-0.535666707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3230	chr14	64854965	64854986	64388247	64388268	75116	hg19					enhancer	enh				GTGGCGCATGCGCAGTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				0.182312952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3231	chr14	64854975	64854997	64388257	64388279	75117	hg19					enhancer	enh				GCATGCGCCACCGCGTCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	direct	Highly Significant	NA				0.414060108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3232	chr14	64855020	64855040	64388302	64388322	75118	hg19					enhancer	enh				GGCGCAGTAGTGTGATCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.770179569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3233	chr14	64855042	64855064	64388324	64388346	75119	hg19					enhancer	enh				GCCAGTCCCTAAGCACGTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.576561597									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3234	chr14	64855065	64855087	64388347	64388369	75120	hg19					enhancer	enh				GGGTTGTCCTGCTTGGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-2.644690711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3235	chr14	64855066	64855087	64388348	64388369	75121	hg19					enhancer	enh				GGTTGTCCTGCTTGGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-2.649099834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3236	chr14	64855067	64855087	64388349	64388369	75122	hg19					enhancer	enh				GTTGTCCTGCTTGGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.334364554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3237	chr14	64855101	64855121	64388383	64388403	75123	hg19					enhancer	enh				GATGGACACCACCAATATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-3.172271014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3238	chr14	64855108	64855129	64388390	64388411	75124	hg19					enhancer	enh				GGTGGTGTCCATCGTGGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-4.293762052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3239	chr14	64855109	64855129	64388391	64388411	75125	hg19					enhancer	enh				GTGGTGTCCATCGTGGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-2.02577706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3240	chr14	64855124	64855146	64388406	64388428	75126	hg19					enhancer	enh				GGCAGCGGACTAATAAAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.478974056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3241	chr14	64855125	64855146	64388407	64388428	75127	hg19					enhancer	enh				GCAGCGGACTAATAAAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-2.17394897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3242	chr14	64855147	64855168	64388429	64388450	75128	hg19					enhancer	enh				GGCGCCAGCAGAAATCCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.260999726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3243	chr14	64855148	64855168	64388430	64388450	75129	hg19					enhancer	enh				GCGCCAGCAGAAATCCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.164066598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-50480	chr14	64855217	64855237	64388499	64388519	75130	hg19	N/A	N/A	N/A	Enhatls54452	enhancer	enh				GCTGTGGACGAGGGCTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTHFD1	indirect	Non Significant	NA				-1.835620094	MTHFD1	chr14	64388030	64463457	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2437
enhrx-55648	chr15	48574654	48574675	48282457	48282478	75131	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GTGGCTAATCATAGGGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				-0.012506223	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574696	48574718	48282499	48282521	75132	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GAAAAGAGAAGAATCCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				-0.227989086	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574718	48574738	48282521	48282541	75133	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GCAACTGTAAGGGCTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				0.189114963	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574724	48574746	48282527	48282549	75134	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GCCCTTACAGTTGCCACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	direct	Highly Significant	NA				0.365029634	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574740	48574761	48282543	48282564	75135	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GCTCTTTGCAGTCCTCTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				-0.492087395	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574822	48574842	48282625	48282645	75136	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GTTGTCACTGTCCTGGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				0.160701608	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574857	48574878	48282660	48282681	75137	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GCTGCACTAGAGCAGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				-0.017364545	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574857	48574879	48282660	48282682	75138	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GGCTGCACTAGAGCAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	indirect	Non Significant	NA				-0.290867058	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-55648	chr15	48574991	48575012	48282794	48282815	75139	hg19	N/A	N/A	N/A	Enhatls59872	enhancer	enh				GTTTATCTGATGATAAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC12A1	direct	Highly Significant	NA				0.84329111	SLC12A1	chr15	48178437	48304078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2350
enhrx-65020	chr16	68877301	68877321	68843398	68843418	75140	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCTTCTGAAATTGTGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	direct	Highly Significant	NA				0.532413137	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877402	68877422	68843499	68843519	75141	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GGGGCGGGGCCAAATCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-0.036730527	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877418	68877438	68843515	68843535	75142	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCTCTGGGCACACTATGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-0.964771858	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877418	68877439	68843515	68843536	75143	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GGCTCTGGGCACACTATGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.032084925	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877423	68877445	68843520	68843542	75144	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCAGAAGGCTCTGGGCACACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.308906859	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877434	68877456	68843531	68843553	75145	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GAGCCTTCTGCCACACTTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.050438578	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877436	68877456	68843533	68843553	75146	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCTTCTGCCACACTTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.087992136	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877440	68877460	68843537	68843557	75147	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCATGTTAAGTGTGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-0.319362316	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877443	68877465	68843540	68843562	75148	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCACACTTAACATGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-0.693407701	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877467	68877489	68843564	68843586	75149	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCGCCCTGCCGAGGCGCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-2.757352202	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877469	68877489	68843566	68843586	75150	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCCTGCCGAGGCGCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-2.844058983	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877473	68877495	68843570	68843592	75151	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GACCCGCTCAGGCGCCTCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.901109753	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877474	68877495	68843571	68843592	75152	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GACCCGCTCAGGCGCCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.548311612	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877482	68877502	68843579	68843599	75153	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCTGAGCGGGTCGCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.730636689	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877499	68877521	68843596	68843618	75154	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCGTGGTGTTACACTCCAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-3.536753855	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877504	68877524	68843601	68843621	75155	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GTGTTACACTCCAGTCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.923751692	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877517	68877537	68843614	68843634	75156	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCTGTCGGGCCGCCATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-1.009298136	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-65020	chr16	68877526	68877546	68843623	68843643	75157	hg19	N/A	enh102545	N/A	N/A	enhancer	enh				GCCCGACAGGCCGTGGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TANGO6	indirect	Non Significant	NA				-2.595069052	TANGO6	chr16	68843530	69085182	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5315
enhrx-68061	chr17	8113786	8113807	8210468	8210489	75158	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GCAGATGATCAGGTAGATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-2.532981997	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113797	8113818	8210479	8210500	75159	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GCCGGGAGTGGGCAGATGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-2.107431496	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113809	8113829	8210491	8210511	75160	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GCAGGCCTTGCGCCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-2.637049046	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113815	8113835	8210497	8210517	75161	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GGCGCAAGGCCTGCGACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.758733617	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113827	8113848	8210509	8210530	75162	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GGTGAGCTGGCCTCCTGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.439617402	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113827	8113847	8210509	8210529	75163	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GTGAGCTGGCCTCCTGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-2.105055682	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113836	8113857	8210518	8210539	75164	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GGCCAGCTCACCTGGGGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-3.054196752	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-68061	chr17	8113837	8113857	8210519	8210539	75165	hg19	N/A	N/A	N/A	Enhatls73055	enhancer	enh				GCCAGCTCACCTGGGGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-2.350129942	AURKB	chr17	8204732	8210584	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1330
enhrx-lit3244	chr17	8113841	8113861	8210523	8210543	75166	hg19					enhancer	enh				GCCTTGGACCCCAGGTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.24534214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3245	chr17	8113849	8113869	8210531	8210551	75167	hg19					enhancer	enh				GTAGCAGTGCCTTGGACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-3.918081314									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3246	chr17	8113852	8113874	8210534	8210556	75168	hg19					enhancer	enh				GTCCAAGGCACTGCTACTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-3.635021976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3247	chr17	8113857	8113879	8210539	8210561	75169	hg19					enhancer	enh				GGCCGGGAGAGTAGCAGTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-0.322680192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3248	chr17	8113857	8113878	8210539	8210560	75170	hg19					enhancer	enh				GCCGGGAGAGTAGCAGTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.661910075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3249	chr17	8113876	8113898	8210558	8210580	75171	hg19					enhancer	enh				GATTCAGTTGTTTGCGGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-0.417699066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3250	chr17	8113880	8113901	8210562	8210583	75172	hg19					enhancer	enh				GCAGATTCAGTTGTTTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.56218952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3251	chr17	8113893	8113913	8210575	8210595	75173	hg19					enhancer	enh				GAATCTGCCACGCCGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-3.813024545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3252	chr17	8113899	8113919	8210581	8210601	75174	hg19					enhancer	enh				GCCACGCCGCGCCCTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-0.032220014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3253	chr17	8113903	8113924	8210585	8210606	75175	hg19					enhancer	enh				GTCCTTGGCCAGGGCGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.261638019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3254	chr17	8113908	8113929	8210590	8210611	75176	hg19					enhancer	enh				GAAAAGTCCTTGGCCAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.916221286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3255	chr17	8113913	8113934	8210595	8210616	75177	hg19					enhancer	enh				GATTTGAAAAGTCCTTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AURKB	indirect	Non Significant	NA				-1.405413989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-68111	chr17	8286362	8286384	8383044	8383066	75178	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GTCGGCCGAGTAGCAGCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.533553053	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286388	8286409	8383070	8383091	75179	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GACTCTCGGGGTCCCCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.147216665	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286403	8286425	8383085	8383107	75180	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GGCATGGTGGCTTCCGACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-0.71567578	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286403	8286424	8383085	8383106	75181	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GCATGGTGGCTTCCGACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.43327807	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286411	8286431	8383093	8383113	75182	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GAAGCCACCATGCCCAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-3.260609185	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286414	8286435	8383096	8383117	75183	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GCCACCATGCCCAAGAACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.155873359	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286418	8286439	8383100	8383121	75184	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GCCATCCGTTCTTGGGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.318271612	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286421	8286442	8383103	8383124	75185	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GCAGCCATCCGTTCTTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.623758231	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286476	8286497	8383158	8383179	75186	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GGCCATCACCGAAGCGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-3.264873035	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286476	8286496	8383158	8383178	75187	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GCCATCACCGAAGCGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.846633235	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-68111	chr17	8286477	8286497	8383159	8383179	75188	hg19	N/A	N/A	N/A	Enhatls73107	enhancer	enh				GGCCATCACCGAAGCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-3.28939312	RPL26	chr17	8377515	8383213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1380
enhrx-lit3256	chr17	8286558	8286580	8383240	8383262	75189	hg19					enhancer	enh				GACCTATGTCTCTCGGAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-0.041178479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3257	chr17	8286591	8286613	8383273	8383295	75190	hg19					enhancer	enh				GTTTGAGCGAGGGGAGTAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.539063158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3258	chr17	8286628	8286649	8383310	8383331	75191	hg19					enhancer	enh				GGCTAGTGTCACCTAGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	direct	Highly Significant	NA				0.460075854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3259	chr17	8286633	8286654	8383315	8383336	75192	hg19					enhancer	enh				GTGTCACCTAGTGGCTAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	direct	Highly Significant	NA				0.2493895									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3260	chr17	8286645	8286665	8383327	8383347	75193	hg19					enhancer	enh				GGCTAGGAGGGGAACTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	direct	Highly Significant	NA				0.291415611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3261	chr17	8286667	8286689	8383349	8383371	75194	hg19					enhancer	enh				GATTGCAAAACTCCCCTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-2.260283528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3262	chr17	8286690	8286710	8383372	8383392	75195	hg19					enhancer	enh				GGAAGGGAGACACTAGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL26	indirect	Non Significant	NA				-1.863730654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3263	chr17	27046828	27046848	28719810	28719830	75196	hg19					enhancer	enh				GCTTTAGTGCCTTTGAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	direct	Highly Significant	NA				0.395852331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3264	chr17	27046917	27046939	28719899	28719921	75197	hg19					enhancer	enh				GCTGATTGGGTAATTTGCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-1.182715401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3265	chr17	27046969	27046991	28719951	28719973	75198	hg19					enhancer	enh				GCTCTTTGGCGCTATAAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-0.445745106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3266	chr17	27046991	27047013	28719973	28719995	75199	hg19					enhancer	enh				GGGTCTCCAATGCTCGTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.243569517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3267	chr17	27046991	27047012	28719973	28719994	75200	hg19					enhancer	enh				GGTCTCCAATGCTCGTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.391059268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3268	chr17	27046991	27047011	28719973	28719993	75201	hg19					enhancer	enh				GTCTCCAATGCTCGTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.119798297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3269	chr17	27047025	27047046	28720007	28720028	75202	hg19					enhancer	enh				GGCGCCGAAAGCGAAGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-4.080654748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3270	chr17	27047026	27047046	28720008	28720028	75203	hg19					enhancer	enh				GCGCCGAAAGCGAAGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.300579986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3271	chr17	27047044	27047064	28720026	28720046	75204	hg19					enhancer	enh				GAAGGTGTGTGTTGGTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.257797835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3272	chr17	27047054	27047074	28720036	28720056	75205	hg19					enhancer	enh				GTTGGTGATGGGGCCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-0.987656786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3273	chr17	27047063	27047084	28720045	28720066	75206	hg19					enhancer	enh				GGGGCCGCAGCTGGTTTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-2.579913243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3274	chr17	27047064	27047084	28720046	28720066	75207	hg19					enhancer	enh				GGGCCGCAGCTGGTTTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-4.416886369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3275	chr17	27047070	27047092	28720052	28720074	75208	hg19					enhancer	enh				GCAATCCCCGGTAAACCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-3.189718654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3276	chr17	27047084	27047105	28720066	28720087	75209	hg19					enhancer	enh				GCTCTGCGGCGCGGCAATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	indirect	Non Significant	NA				-3.282044362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3277	chr17	27047093	27047113	28720075	28720095	75210	hg19					enhancer	enh				GCGCCGCAGAGCGAACGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	direct	Highly Significant	NA				0.235599471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3278	chr17	27047101	27047121	28720083	28720103	75211	hg19					enhancer	enh				GAGCGAACGAATTGGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL23A	direct	Highly Significant	NA				0.595617494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3279	chr17	78120750	78120771	80146951	80146972	75212	hg19					enhancer	enh				GACTCTGAATCATGGCGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-1.293576538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3280	chr17	78120773	78120793	80146974	80146994	75213	hg19					enhancer	enh				GCGCGCGCTGTGCTCTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-2.386232754									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3281	chr17	78120921	78120942	80147122	80147143	75214	hg19					enhancer	enh				GTTCTCGGCAGCGGCACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-2.257964197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3282	chr17	78120988	78121008	80147189	80147209	75215	hg19					enhancer	enh				GTACGTGCGTACGCGCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.109725644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3283	chr17	78121000	78121020	80147201	80147221	75216	hg19					enhancer	enh				GCGCGACGCGGCCACGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.047755558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3284	chr17	78121030	78121050	80147231	80147251	75217	hg19					enhancer	enh				GGCACTCTTCGTCACGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.944234733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3285	chr17	78121051	78121071	80147252	80147272	75218	hg19					enhancer	enh				GGGAACTGGGCGTTTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.262179281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3286	chr17	78121062	78121082	80147263	80147283	75219	hg19					enhancer	enh				GTTTGCCGCAGGGAAAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.314082795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3287	chr17	78121098	78121118	80147299	80147319	75220	hg19					enhancer	enh				GCGCCATATGCAGTTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-0.523816261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3288	chr17	78121104	78121124	80147305	80147325	75221	hg19					enhancer	enh				GATCCCGCGGGAACTGCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EIF4A3	indirect	Non Significant	NA				-1.124444237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3289	chr18	2655719	2655741	2655720	2655742	75222	hg19					enhancer	enh				GCCGCCGCCGGGACTGTGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.924607952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3290	chr18	2655721	2655743	2655722	2655744	75223	hg19					enhancer	enh				GCCACAGTCCCGGCGGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.330389797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3291	chr18	2655741	2655763	2655742	2655764	75224	hg19					enhancer	enh				GCTGGTCGCGGGTCGCACCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	direct	Highly Significant	NA				0.626870473									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3292	chr18	2655751	2655773	2655752	2655774	75225	hg19					enhancer	enh				GGTCGCACCGTGAGGCTCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.206230965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3293	chr18	2655752	2655773	2655753	2655774	75226	hg19					enhancer	enh				GTCGCACCGTGAGGCTCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.283631137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3294	chr18	2655775	2655796	2655776	2655797	75227	hg19					enhancer	enh				GCGGCGATAGGCGCTGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.525474152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3295	chr18	2655780	2655801	2655781	2655802	75228	hg19					enhancer	enh				GATAGGCGCTGGGCCCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.714452125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3296	chr18	2655797	2655817	2655798	2655818	75229	hg19					enhancer	enh				GGCGCGCTCCTCACCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.219490554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3297	chr18	2655803	2655824	2655804	2655825	75230	hg19					enhancer	enh				GACGCGCGGCGCGCTCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.793366066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3298	chr18	2655814	2655835	2655815	2655836	75231	hg19					enhancer	enh				GCCGCGCGTCCCCTTCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.826940169									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3299	chr18	2655846	2655868	2655847	2655869	75232	hg19					enhancer	enh				GCCGCGGAAGTGACGTGGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.014050881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3300	chr18	2655849	2655869	2655850	2655870	75233	hg19					enhancer	enh				GCGGAAGTGACGTGGTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.001920813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3301	chr18	2655852	2655873	2655853	2655874	75234	hg19					enhancer	enh				GAAGTGACGTGGTGCACGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	direct	Highly Significant	NA				0.747216516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3302	chr18	2655869	2655889	2655870	2655890	75235	hg19					enhancer	enh				GGGCAGGAGCGCGTTTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.930162767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3303	chr18	2655875	2655897	2655876	2655898	75236	hg19					enhancer	enh				GAGCGCGTTTGAATCGGTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.072087528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3304	chr18	2655877	2655897	2655878	2655898	75237	hg19					enhancer	enh				GCGCGTTTGAATCGGTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.261020352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3305	chr18	2655897	2655917	2655898	2655918	75238	hg19					enhancer	enh				GGCAGGCGCGAGGATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-2.88052434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3306	chr18	2655897	2655919	2655898	2655920	75239	hg19					enhancer	enh				GCGGCAGGCGCGAGGATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-2.648773376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3307	chr18	2655907	2655927	2655908	2655928	75240	hg19					enhancer	enh				GCCGAGCAGCGGCAGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-2.547456127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3308	chr18	2655920	2655941	2655921	2655942	75241	hg19					enhancer	enh				GCTCGGCCGCCGCCGCTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.746704827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3309	chr18	2655929	2655950	2655930	2655951	75242	hg19					enhancer	enh				GCAGCTCCTCGTCAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-0.913097685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3310	chr18	2655935	2655957	2655936	2655958	75243	hg19					enhancer	enh				GCGCGCTGCAGCTCCTCGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.804918556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3311	chr18	2655935	2655955	2655936	2655956	75244	hg19					enhancer	enh				GCGCTGCAGCTCCTCGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.596926279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3312	chr18	2655943	2655964	2655944	2655965	75245	hg19					enhancer	enh				GAGCTGCAGCGCGCCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				0.089948267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3313	chr18	2655960	2655980	2655961	2655981	75246	hg19					enhancer	enh				GCCGAGGCCTCGAGCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.174231608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3314	chr18	2655966	2655987	2655967	2655988	75247	hg19					enhancer	enh				GCCTCGAGCCGCCCCGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.334603083									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3315	chr18	2655980	2656000	2655981	2656001	75248	hg19					enhancer	enh				GCCTTCAGCTCCAGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMCHD1	indirect	Non Significant	NA				-1.343481234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-76740	chr18	13913315	13913336	13913316	13913337	75249	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GAGTGGGTCACACTGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.465912356	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913323	13913345	13913324	13913346	75250	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GAAAGGTCCGAGTGGGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.480592838	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913332	13913353	13913333	13913354	75251	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTGGCAGGGAAAGGTCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.417165068	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913342	13913364	13913343	13913365	75252	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GCAGCACAGCCGTGGCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				0.114262663	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913348	13913368	13913349	13913369	75253	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTGAGCAGCACAGCCGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.287209216	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913385	13913405	13913386	13913406	75254	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTCCCAGCATCAAAACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				0.044798671	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913388	13913408	13913389	13913409	75255	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GGTGTCCCAGCATCAAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				0.191727147	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913456	13913478	13913457	13913479	75256	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GGGTAACGCACAGAGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.074595408	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913456	13913477	13913457	13913478	75257	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GGTAACGCACAGAGCCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.390392841	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913456	13913476	13913457	13913477	75258	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTAACGCACAGAGCCTGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.206313107	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913479	13913501	13913480	13913502	75259	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GCCAAGCGCTGTGCTAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.742246599	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913558	13913580	13913559	13913581	75260	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTTCTCTGACTATGAGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.20565009	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913622	13913643	13913623	13913644	75261	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GCTGGTGCAGACCCACCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.7313133	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913641	13913661	13913642	13913662	75262	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTGAACAGACAGGCAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.221193001	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913655	13913675	13913656	13913676	75263	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GTTCACACGTTCTCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	direct	Highly Significant	NA				0.251346299	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-76740	chr18	13913675	13913695	13913676	13913696	75264	hg19	N/A	N/A	N/A	Enhatls82347	enhancer	enh				GAAGGACGTGTCCAGGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MC2R	indirect	Non Significant	NA				-0.344679834	MC2R	chr18	13882043	13915707	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	758
enhrx-78299	chr18	55288839	55288859	57621607	57621627	75265	hg19	N/A	N/A	N/A	Enhatls84000	enhancer	enh				GCCCACTCTGGTAGGCACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.053816173	NARS1	chr18	57600655	57622213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2317
enhrx-78299	chr18	55288860	55288880	57621628	57621648	75266	hg19	N/A	N/A	N/A	Enhatls84000	enhancer	enh				GGAAAGCGCCGAAACCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	direct	Highly Significant	NA				0.462683506	NARS1	chr18	57600655	57622213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2317
enhrx-78299	chr18	55288915	55288935	57621683	57621703	75267	hg19	N/A	N/A	N/A	Enhatls84000	enhancer	enh				GTGAGACTCAGTGTATGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.651677237	NARS1	chr18	57600655	57622213	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2317
enhrx-lit3316	chr18	55288942	55288963	57621710	57621731	75268	hg19					enhancer	enh				GCACCATGCCTGCAGTGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-1.416656724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3317	chr18	55288948	55288968	57621716	57621736	75269	hg19					enhancer	enh				GACCAGGGCCACTGCAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-2.034533388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3318	chr18	55288953	55288975	57621721	57621743	75270	hg19					enhancer	enh				GCAGTGGCCCTGGTCACCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-1.415532862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3319	chr18	55288964	55288986	57621732	57621754	75271	hg19					enhancer	enh				GTCTGTGTCCTTGGAGGTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.76524018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3320	chr18	55288996	55289017	57621764	57621785	75272	hg19					enhancer	enh				GTTGGAGTCATAAGACGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-2.032071893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3321	chr18	55289001	55289023	57621769	57621791	75273	hg19					enhancer	enh				GTCTTATGACTCCAACGTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.018329282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3322	chr18	55289002	55289024	57621770	57621792	75274	hg19					enhancer	enh				GGTGCACGTTGGAGTCATAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-1.714621851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3323	chr18	55289002	55289023	57621770	57621791	75275	hg19					enhancer	enh				GTGCACGTTGGAGTCATAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-1.667068194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3324	chr18	55289015	55289036	57621783	57621804	75276	hg19					enhancer	enh				GCGGAAACCGCCGGTGCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	direct	Highly Significant	NA				0.505237917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3325	chr18	55289025	55289045	57621793	57621813	75277	hg19					enhancer	enh				GCCGGAATCGCGGAAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.858747274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3326	chr18	55289048	55289070	57621816	57621838	75278	hg19					enhancer	enh				GCATCAGAGAGCGTAGATCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-3.188925702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3327	chr18	55289078	55289098	57621846	57621866	75279	hg19					enhancer	enh				GGCGCTCGGCCGATTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.243237696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3328	chr18	55289088	55289108	57621856	57621876	75280	hg19					enhancer	enh				GCCGAGCGCCGCGGTTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.281123784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3329	chr18	55289098	55289118	57621866	57621886	75281	hg19					enhancer	enh				GCGGTTCCATTGGTTACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.639363786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3330	chr18	55289133	55289155	57621901	57621923	75282	hg19					enhancer	enh				GCCGGGGCCGCCATCTTTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				0.009678571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3331	chr18	55289174	55289194	57621942	57621962	75283	hg19					enhancer	enh				GGGCGGGGCGTCTCTGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.121382798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3332	chr18	55289191	55289212	57621959	57621980	75284	hg19					enhancer	enh				GAGCTGCACAAACGCGTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NARS	indirect	Non Significant	NA				-0.033484706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3333	chr19	3985264	3985284	3985266	3985286	75285	hg19					enhancer	enh				GCCAGGAGGAGACGTAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.457533438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3334	chr19	3985356	3985377	3985358	3985379	75286	hg19					enhancer	enh				GCGAGGCAGGGTTACTCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-1.553387654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3335	chr19	3985361	3985383	3985363	3985385	75287	hg19					enhancer	enh				GCAGGGTTACTCACCATGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-1.008616136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3336	chr19	3985366	3985387	3985368	3985389	75288	hg19					enhancer	enh				GTTACTCACCATGGTGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.385643634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3337	chr19	3985384	3985404	3985386	3985406	75289	hg19					enhancer	enh				GGATGGCGGTGGATTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-1.971068727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3338	chr19	3985414	3985434	3985416	3985436	75290	hg19					enhancer	enh				GAAAGAAGCGAGTCGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.155673507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3339	chr19	3985418	3985438	3985420	3985440	75291	hg19					enhancer	enh				GAAGCGAGTCGCGCCGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.176824853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3340	chr19	3985421	3985441	3985423	3985443	75292	hg19					enhancer	enh				GCGAGTCGCGCCGAGGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.195666519									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3341	chr19	3985430	3985450	3985432	3985452	75293	hg19					enhancer	enh				GCCGAGGATGGCGGCGACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-1.897760499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3342	chr19	3985502	3985524	3985504	3985526	75294	hg19					enhancer	enh				GCAGTCACATGACCCGCCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-0.088055786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3343	chr19	3985511	3985531	3985513	3985533	75295	hg19					enhancer	enh				GTCATGTGACTGCGCTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-0.737885985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3344	chr19	3985516	3985536	3985518	3985538	75296	hg19					enhancer	enh				GTGACTGCGCTGCGAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-0.063882229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3345	chr19	3985540	3985562	3985542	3985564	75297	hg19					enhancer	enh				GAAGGGACGCCGCGCAAGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-0.445073436									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3346	chr19	3985545	3985565	3985547	3985567	75298	hg19					enhancer	enh				GACGCCGCGCAAGCGCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-0.232044204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3347	chr19	3985552	3985574	3985554	3985576	75299	hg19					enhancer	enh				GACACGCCTCCGTGCGCTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				0.134745254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3348	chr19	3985580	3985600	3985582	3985602	75300	hg19					enhancer	enh				GCGCCGAATGGGTTAACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	direct	Highly Significant	NA				0.423613564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3349	chr19	3985591	3985611	3985593	3985613	75301	hg19					enhancer	enh				GCGCCGCGCCGGCGCCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				0.191367973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3350	chr19	3985604	3985625	3985606	3985627	75302	hg19					enhancer	enh				GCGGCGCTCTAGAATAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EEF2	indirect	Non Significant	NA				-2.34081992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3351	chr19	8386193	8386213	8321309	8321329	75303	hg19					enhancer	enh				GCTGCGGAACTGGGCGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.643399563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3352	chr19	8386278	8386298	8321394	8321414	75304	hg19					enhancer	enh				GTCTCCACCGCTGGGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	direct	Highly Significant	NA				0.513783059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3353	chr19	8386293	8386314	8321409	8321430	75305	hg19					enhancer	enh				GCTGCTGGGAAAGACGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.56538853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3354	chr19	8386336	8386358	8321452	8321474	75306	hg19					enhancer	enh				GCGGTGCTAGAACGTCCTATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.841593165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3355	chr19	8386434	8386456	8321550	8321572	75307	hg19					enhancer	enh				GCCTATCAAGCTGGCCAGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-3.371911627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3356	chr19	8386484	8386506	8321600	8321622	75308	hg19					enhancer	enh				GGAGGGATTAGAGGAGCCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-2.739881483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3357	chr19	8386489	8386510	8321605	8321626	75309	hg19					enhancer	enh				GATTAGAGGAGCCAAACGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.443318498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3358	chr19	8386512	8386533	8321628	8321649	75310	hg19					enhancer	enh				GAAAGAAGCTGGGTTCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.572734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3359	chr19	8386517	8386537	8321633	8321653	75311	hg19					enhancer	enh				GAACCCAGCTTCTTTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.498360963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3360	chr19	8386524	8386544	8321640	8321660	75312	hg19					enhancer	enh				GTGACCTGGAGGAAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-1.607609896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3361	chr19	8386535	8386557	8321651	8321673	75313	hg19					enhancer	enh				GCCCAGGACCTTGGTGACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS28	indirect	Non Significant	NA				-0.046761656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-82929	chr19	18900676	18900697	18789867	18789888	75314	hg19	N/A	N/A	N/A	Enhatls88951	enhancer	enh				GTCTCCCGGGCGGCGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				-0.350036722	COMP	chr19	18782772	18791305	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3899
enhrx-82929	chr19	18900739	18900761	18789930	18789952	75315	hg19	N/A	N/A	N/A	Enhatls88951	enhancer	enh				GGCTAGCGCACCTCGTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				-0.08347937	COMP	chr19	18782772	18791305	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3899
enhrx-82929	chr19	18900740	18900761	18789931	18789952	75316	hg19	N/A	N/A	N/A	Enhatls88951	enhancer	enh				GCTAGCGCACCTCGTTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	direct	Highly Significant	NA				0.33289562	COMP	chr19	18782772	18791305	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3899
enhrx-lit3362	chr19	18900752	18900772	18789943	18789963	75317	hg19					enhancer	enh				GCACTGCACCGACGTCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.033505119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3363	chr19	18900774	18900795	18789965	18789986	75318	hg19					enhancer	enh				GCCGTTGCCCGTGAAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				-0.091974904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3364	chr19	18900780	18900801	18789971	18789992	75319	hg19					enhancer	enh				GCCCGTGAAGCCCGCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.199955214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3365	chr19	18900807	18900829	18789998	18790020	75320	hg19					enhancer	enh				GCAGCGCGCGCCGCTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.178430744									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3366	chr19	18900808	18900829	18789999	18790020	75321	hg19					enhancer	enh				GACGGAGAGCGGCGCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	direct	Highly Significant	NA				0.227668338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3367	chr19	18900814	18900836	18790005	18790027	75322	hg19					enhancer	enh				GCGCCGCTCTCCGTCTGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.075424558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3368	chr19	18900816	18900836	18790007	18790027	75323	hg19					enhancer	enh				GCCGCTCTCCGTCTGGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				-0.060504646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3369	chr19	18900820	18900840	18790011	18790031	75324	hg19					enhancer	enh				GCCTGCATCCAGACGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	direct	Highly Significant	NA				0.745922387									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3370	chr19	18900826	18900847	18790017	18790038	75325	hg19					enhancer	enh				GTCTGGATGCAGGCCACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.054590413									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3371	chr19	18900849	18900871	18790040	18790062	75326	hg19					enhancer	enh				GAAGCAGAAGCCGGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	direct	Highly Significant	NA				0.754394074									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-82930	chr19	18900953	18900973	18790144	18790164	75327	hg19	N/A	N/A	N/A	Enhatls88952	enhancer	enh				GCTGATCGGTGGCTCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COMP	indirect	Non Significant	NA				0.02812833	COMP	chr19	18782772	18791305	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3900
enhrx-lit3372	chr19	36053393	36053415	35562491	35562513	75328	hg19					enhancer	enh				GATGGCGGCGGCAACCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.915095837									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3373	chr19	36053431	36053451	35562529	35562549	75329	hg19					enhancer	enh				GTTCGCGAGGCAGCTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.356732327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3374	chr19	36053440	36053462	35562538	35562560	75330	hg19					enhancer	enh				GCCTCGCGAACTTGACGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				0.083998484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3375	chr19	36053453	36053474	35562551	35562572	75331	hg19					enhancer	enh				GACGTACTCTGGGGTGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	direct	Highly Significant	NA				0.247076346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3376	chr19	36053474	36053496	35562572	35562594	75332	hg19					enhancer	enh				GCCCAACGCACTGCGGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				0.10064149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3377	chr19	36053483	36053503	35562581	35562601	75333	hg19					enhancer	enh				GGGATGGGCCCAACGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				0.009956764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3378	chr19	36053483	36053505	35562581	35562603	75334	hg19					enhancer	enh				GCGGGATGGGCCCAACGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.094108418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3379	chr19	36053498	36053519	35562596	35562617	75335	hg19					enhancer	enh				GCTGAGCTGCTGCTGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.422370834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-83833	chr19	36053520	36053542	35562618	35562640	75336	hg19	N/A	N/A	N/A	Enhatls89898	enhancer	enh				GCCAGGCTCGCAGAGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.592829131	ATP4A	chr19	35550030	35563658	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4803
enhrx-83833	chr19	36053529	36053550	35562627	35562648	75337	hg19	N/A	N/A	N/A	Enhatls89898	enhancer	enh				GCAGAGAGGCCCTGGGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP4A	indirect	Non Significant	NA				-0.139764348	ATP4A	chr19	35550030	35563658	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4803
enhrx-85072	chr19	42364199	42364219	41860129	41860149	75338	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GAAAGTTCGTCCCCGCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.833567571	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364288	42364308	41860218	41860238	75339	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GGGCGCACAAGTCGGGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.829926321	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364295	42364316	41860225	41860246	75340	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GGTTTCCCGGGCGCACAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.296731411	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364295	42364315	41860225	41860245	75341	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GTTTCCCGGGCGCACAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.770961994	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364296	42364316	41860226	41860246	75342	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GGTTTCCCGGGCGCACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.599376898	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364317	42364338	41860247	41860268	75343	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCCAGGGGAAAGGGAACGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-6.05976818	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364318	42364338	41860248	41860268	75344	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCCAGGGGAAAGGGAACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	direct	Highly Significant	NA				0.825953153	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364336	42364357	41860266	41860287	75345	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCTGGCAGCGCGGAGGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-3.277426036	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364343	42364364	41860273	41860294	75346	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCGCGGAGGCCGCACGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.990847419	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364343	42364364	41860273	41860294	75347	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCGCGGAGGCCGCACGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.990847419	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364345	42364366	41860275	41860296	75348	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCGGAGGCCGCACGGTAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.755021709	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364345	42364366	41860275	41860296	75349	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCGGAGGCCGCACGGTAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.755021709	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364345	42364365	41860275	41860295	75350	hg19	N/A	enh5148	N/A	N/A	enhancer	enh				GCGGAGGCCGCACGGTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.687993003	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364345	42364365	41860275	41860295	75351	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCGGAGGCCGCACGGTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-1.687993003	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364369	42364391	41860299	41860321	75352	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCTCCGAGCTGGACCGGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	direct	Highly Significant	NA				0.248633769	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364405	42364426	41860335	41860356	75353	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCGCTCTGAGGCTTCGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.28912254	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364414	42364434	41860344	41860364	75354	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCCTCAGAGCGCGTGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.021108732	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364420	42364442	41860350	41860372	75355	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GAGCGCGTGCCTGAGGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.402904371	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-85072	chr19	42364471	42364491	41860401	41860421	75356	hg19	N/A	enh5148	N/A	Enhatls91197	enhancer	enh				GCACGTGGCCGCGGCTCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPS19	indirect	Non Significant	NA				-0.82416389	RPS19	chr19	41860254	41872925	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6042
enhrx-lit3380	chr19	49122273	49122293	48619016	48619036	75357	hg19					enhancer	enh				GAGGGAGCAATTCCCGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-0.919331594									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3381	chr19	49122328	49122349	48619071	48619092	75358	hg19					enhancer	enh				GCCCCTAGCCCAAAACCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				0.087354139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3382	chr19	49122346	49122368	48619089	48619111	75359	hg19					enhancer	enh				GATAATCCGCTGCCATCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-0.609217401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3383	chr19	49122382	49122402	48619125	48619145	75360	hg19					enhancer	enh				GCAAAGCGAGCTCACCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-3.392081899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3384	chr19	49122400	49122421	48619143	48619164	75361	hg19					enhancer	enh				GATGGCGCCTCCTGCTCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-1.607053484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3385	chr19	49122404	49122426	48619147	48619169	75362	hg19					enhancer	enh				GCGCCTCCTGCTCGGCCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-1.974328151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3386	chr19	49122406	49122426	48619149	48619169	75363	hg19					enhancer	enh				GCCTCCTGCTCGGCCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-4.890754507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3387	chr19	49122417	49122439	48619160	48619182	75364	hg19					enhancer	enh				GGCCAGGTCCGGAAAGAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-5.707713246									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3388	chr19	49122418	49122440	48619161	48619183	75365	hg19					enhancer	enh				GCCAGGTCCGGAAAGAGAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-2.691032295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3389	chr19	49122422	49122444	48619165	48619187	75366	hg19					enhancer	enh				GCCCGTTCTCTCTTTCCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-2.301033516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3390	chr19	49122423	49122444	48619166	48619187	75367	hg19					enhancer	enh				GTCCGGAAAGAGAGAACGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-2.128457746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3391	chr19	49122451	49122473	48619194	48619216	75368	hg19					enhancer	enh				GGCGGGGAAAGCCTCAAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	direct	Highly Significant	NA				0.242677736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3392	chr19	49122452	49122473	48619195	48619216	75369	hg19					enhancer	enh				GCGGGGAAAGCCTCAAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-1.122784124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3393	chr19	49122475	49122495	48619218	48619238	75370	hg19					enhancer	enh				GCGCCGCCGTGACGTCACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				-0.286806254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3394	chr19	49122485	49122505	48619228	48619248	75371	hg19					enhancer	enh				GACGTCACATGGGTGCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	indirect	Non Significant	NA				0.13917449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3395	chr19	49122548	49122569	48619291	48619312	75372	hg19					enhancer	enh				GACTGACTAGCCGGGCGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RPL18	direct	Highly Significant	NA				0.613188965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3396	chr19	50432366	50432386	49929109	49929129	75373	hg19					enhancer	enh				GCCCTCGCGCGGCCCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.890432364									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3397	chr19	50432420	50432441	49929163	49929184	75374	hg19					enhancer	enh				GGACAGATATATACTGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.863270117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3398	chr19	50432420	50432440	49929163	49929183	75375	hg19					enhancer	enh				GACAGATATATACTGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-0.410580597									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3399	chr19	50432427	50432448	49929170	49929191	75376	hg19					enhancer	enh				GGACTGGGGACAGATATATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-6.295376122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3400	chr19	50432427	50432447	49929170	49929190	75377	hg19					enhancer	enh				GACTGGGGACAGATATATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-6.376550686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3401	chr19	50432444	50432465	49929187	49929208	75378	hg19					enhancer	enh				GAATGAGGCGGCCCCGGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-0.245020702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3402	chr19	50432449	50432471	49929192	49929214	75379	hg19					enhancer	enh				GACAGGGAATGAGGCGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-0.070021264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3403	chr19	50432450	50432471	49929193	49929214	75380	hg19					enhancer	enh				GACAGGGAATGAGGCGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.800526161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3404	chr19	50432457	50432479	49929200	49929222	75381	hg19					enhancer	enh				GATCCGAGGACAGGGAATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.909092052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3405	chr19	50432460	50432481	49929203	49929224	75382	hg19					enhancer	enh				GTGATCCGAGGACAGGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-2.999424793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3406	chr19	50432467	50432487	49929210	49929230	75383	hg19					enhancer	enh				GAGACTGTGATCCGAGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.365827096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3407	chr19	50432468	50432490	49929211	49929233	75384	hg19					enhancer	enh				GAAGAGACTGTGATCCGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	direct	Highly Significant	NA				0.206299048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3408	chr19	50432473	50432494	49929216	49929237	75385	hg19					enhancer	enh				GTGAGAAGAGACTGTGATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-2.416487541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3409	chr19	50432503	50432525	49929246	49929268	75386	hg19					enhancer	enh				GCCGCCTCTGCCTGCGTAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.913906677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3410	chr19	50432510	50432530	49929253	49929273	75387	hg19					enhancer	enh				GGCCGGGGCTACGCAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-2.775229587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3411	chr19	50432516	50432537	49929259	49929280	75388	hg19					enhancer	enh				GAGCCATGGCCGGGGCTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-2.386947722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3412	chr19	50432525	50432546	49929268	49929289	75389	hg19					enhancer	enh				GAGGCTACAGAGCCATGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-0.540118483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3413	chr19	50432531	50432551	49929274	49929294	75390	hg19					enhancer	enh				GGGTCGAGGCTACAGAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATF5	indirect	Non Significant	NA				-1.287721894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3414	chr2	264771	264792	264771	264792	75391	hg19					enhancer	enh				GTCCTATGACGGTAGTAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.647322896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3415	chr2	264783	264805	264783	264805	75392	hg19					enhancer	enh				GCCTGCGGAGGCGGTCCTATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-1.569731962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3416	chr2	264803	264824	264803	264824	75393	hg19					enhancer	enh				GCGCACTGGAGCCGATTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.460876136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3417	chr2	264843	264864	264843	264864	75394	hg19					enhancer	enh				GCTGCCCTGTTGGCGTTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.38959543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3418	chr2	264855	264875	264855	264875	75395	hg19					enhancer	enh				GCGTTGGTGCGGGACTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.570018178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3419	chr2	264896	264917	264896	264917	75396	hg19					enhancer	enh				GGCAGTGCGCCTGCGCCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.477670362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3420	chr2	264897	264917	264897	264917	75397	hg19					enhancer	enh				GCAGTGCGCCTGCGCCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.184703262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3421	chr2	264936	264957	264936	264957	75398	hg19					enhancer	enh				GTGTCTCGGCGCCTCTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				0.091038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3422	chr2	264938	264958	264938	264958	75399	hg19					enhancer	enh				GTCTCGGCGCCTCTGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.181768572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3423	chr2	264943	264965	264943	264965	75400	hg19					enhancer	enh				GGCGCCTCTGCGCGCGGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	direct	Highly Significant	NA				0.298537301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3424	chr2	264944	264965	264944	264965	75401	hg19					enhancer	enh				GCGCCTCTGCGCGCGGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	direct	Highly Significant	NA				0.323753283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3425	chr2	264954	264974	264954	264974	75402	hg19					enhancer	enh				GCGCGGGAAGATGGCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	direct	Highly Significant	NA				0.257205265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3426	chr2	264983	265004	264983	265004	75403	hg19					enhancer	enh				GACACACAAACAGCACGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				0.007272739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3427	chr2	265036	265058	265036	265058	75404	hg19					enhancer	enh				GACGTCCTCTGGAGAGTTGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	direct	Highly Significant	NA				0.764586948									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3428	chr2	265039	265059	265039	265059	75405	hg19					enhancer	enh				GTCCTCTGGAGAGTTGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.308723804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3429	chr2	265065	265086	265065	265086	75406	hg19					enhancer	enh				GTGCGCTGTAGGTTGTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACP1	indirect	Non Significant	NA				-0.130089478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88102	chr2	677256	677278	677256	677278	75407	hg19	N/A	N/A	N/A	Enhatls94329	enhancer	enh				GCCCGCGTAACCACCAGTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.788839263	TMEM18	chr2	663876	677406	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	28
enhrx-88102	chr2	677276	677296	677276	677296	75408	hg19	N/A	N/A	N/A	Enhatls94329	enhancer	enh				GCCGCGAGTTACCGTGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.854521059	TMEM18	chr2	663876	677406	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	28
enhrx-88102	chr2	677281	677301	677281	677301	75409	hg19	N/A	N/A	N/A	Enhatls94329	enhancer	enh				GAGTTACCGTGAGCACGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.531342623	TMEM18	chr2	663876	677406	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	28
enhrx-lit3430	chr2	677293	677313	677293	677313	75410	hg19					enhancer	enh				GCACGGCTGGGATGCTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.123208337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3431	chr2	677312	677332	677312	677332	75411	hg19					enhancer	enh				GGGGAAAGAGCTGACAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.459096417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3432	chr2	677319	677339	677319	677339	75412	hg19					enhancer	enh				GAGCTGACAGAGAAGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-2.772582563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3433	chr2	677324	677344	677324	677344	75413	hg19					enhancer	enh				GACAGAGAAGGCGGACGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.017305727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3434	chr2	677360	677382	677360	677382	75414	hg19					enhancer	enh				GTTCGGCGGTTGCTGTGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	direct	Highly Significant	NA				0.742686534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3435	chr2	677361	677382	677361	677382	75415	hg19					enhancer	enh				GTTCGGCGGTTGCTGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.53796376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3436	chr2	677384	677404	677384	677404	75416	hg19					enhancer	enh				GGCCTGGCCAGAATCCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.100162426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3437	chr2	677385	677407	677385	677407	75417	hg19					enhancer	enh				GCCTGGCCAGAATCCACAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.17253152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3438	chr2	677422	677443	677422	677443	75418	hg19					enhancer	enh				GAAGGGCAGATCTCACGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.111776295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3439	chr2	677440	677462	677440	677462	75419	hg19					enhancer	enh				GCAAGCGCAAGTTTCGTGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.77840728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3440	chr2	677441	677462	677441	677462	75420	hg19					enhancer	enh				GCAAGCGCAAGTTTCGTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-0.847723942									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3441	chr2	677499	677519	677499	677519	75421	hg19					enhancer	enh				GATATCGCGATATTTCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.049443725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3442	chr2	677535	677555	677535	677555	75422	hg19					enhancer	enh				GAAAACTTACTACGCTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.055268668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3443	chr2	677557	677577	677557	677577	75423	hg19					enhancer	enh				GGACTTGTGCTCGCTCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.119725173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3444	chr2	677565	677587	677565	677587	75424	hg19					enhancer	enh				GCTCGCTCCGCCAGGAGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				0.046841824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3445	chr2	677586	677608	677586	677608	75425	hg19					enhancer	enh				GTTAACGAACTAAAGACGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM18	indirect	Non Significant	NA				-1.373635038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3446	chr2	3383346	3383366	3379575	3379595	75426	hg19					enhancer	enh				GGTCCGCTCCCCTCAACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.22076264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3447	chr2	3383382	3383403	3379611	3379632	75427	hg19					enhancer	enh				GCCCTAGGTGTGAACGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.844904254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3448	chr2	3383408	3383430	3379637	3379659	75428	hg19					enhancer	enh				GCCCCGCCCACAGCAGACGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.383347818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3449	chr2	3383432	3383454	3379661	3379683	75429	hg19					enhancer	enh				GAAACGAACCCCATTTCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				0.121659296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3450	chr2	3383437	3383457	3379666	3379686	75430	hg19					enhancer	enh				GAACCCCATTTCCGGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.817090202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3451	chr2	3383459	3383481	3379688	3379710	75431	hg19					enhancer	enh				GCAGGGCCTCGGGTTCCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				0.072819662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3452	chr2	3383462	3383482	3379691	3379711	75432	hg19					enhancer	enh				GGGCCTCGGGTTCCTGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.133421361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3453	chr2	3383477	3383497	3379706	3379726	75433	hg19					enhancer	enh				GTTCTGCTCAGGCCCGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.131223233									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3454	chr2	3383477	3383498	3379706	3379727	75434	hg19					enhancer	enh				GCATCGGGCCTGAGCAGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.486722176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3455	chr2	3383488	3383508	3379717	3379737	75435	hg19					enhancer	enh				GAGCAGAACTAGGCGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.537466737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3456	chr2	3383488	3383509	3379717	3379738	75436	hg19					enhancer	enh				GCGGCGCGCCTAGTTCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.865708947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3457	chr2	3383493	3383513	3379722	3379742	75437	hg19					enhancer	enh				GAACTAGGCGCGCCGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.203634749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3458	chr2	3383514	3383536	3379743	3379765	75438	hg19					enhancer	enh				GCTCTGTACGCCTGCGCGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.591300795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3459	chr2	3383515	3383536	3379744	3379765	75439	hg19					enhancer	enh				GCTCTGTACGCCTGCGCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				0.103784406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3460	chr2	3383521	3383543	3379750	3379772	75440	hg19					enhancer	enh				GCAGGCGTACAGAGCTCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.249259493									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3461	chr2	3383521	3383542	3379750	3379771	75441	hg19					enhancer	enh				GCAGGCGTACAGAGCTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				-0.158667737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3462	chr2	3383551	3383571	3379780	3379800	75442	hg19					enhancer	enh				GCCGGGAATCGGAGAGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.441490988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3463	chr2	3383557	3383578	3379786	3379807	75443	hg19					enhancer	enh				GACAGAAGCCGGGAATCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	direct	Highly Significant	NA				0.466201843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3464	chr2	3383595	3383615	3379824	3379844	75444	hg19					enhancer	enh				GTCACCTGCGGCCGTGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAPPC12	indirect	Non Significant	NA				0.157661245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3465	chr2	3649205	3649225	3601615	3601635	75445	hg19					enhancer	enh				GATGTCCAAGAATGGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				0.174924862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3466	chr2	3649227	3649247	3601637	3601657	75446	hg19					enhancer	enh				GCTGAAGCCGTCTCTCATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	direct	Highly Significant	NA				0.215631907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3467	chr2	3649316	3649338	3601726	3601748	75447	hg19					enhancer	enh				GCCAGGGCTTGGGCACGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				0.102363037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3468	chr2	3649329	3649349	3601739	3601759	75448	hg19					enhancer	enh				GTTAGGGCGGAGCCAGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				0.004249463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3469	chr2	3649335	3649356	3601745	3601766	75449	hg19					enhancer	enh				GATTAGAGTTAGGGCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	direct	Highly Significant	NA				0.281241191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3470	chr2	3649342	3649363	3601752	3601773	75450	hg19					enhancer	enh				GAGAGAGGATTAGAGTTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				-0.608245019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3471	chr2	3649375	3649395	3601785	3601805	75451	hg19					enhancer	enh				GCAAGGGTTGATGAAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				0.066862632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3472	chr2	3649391	3649411	3601801	3601821	75452	hg19					enhancer	enh				GTCCGTTTCCACTGAGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				-0.559911768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3473	chr2	3649397	3649418	3601807	3601828	75453	hg19					enhancer	enh				GTTAAATGTCCGTTTCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				-0.217451977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3474	chr2	3649399	3649419	3601809	3601829	75454	hg19					enhancer	enh				GTGGAAACGGACATTTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				-0.064420962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3475	chr2	3649562	3649582	3601972	3601992	75455	hg19					enhancer	enh				GTTCTCCCAGAAATGTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	indirect	Non Significant	NA				-0.43393569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3476	chr2	3649574	3649594	3601984	3602004	75456	hg19					enhancer	enh				GGGAGAACTCCTCGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COLEC11	direct	Highly Significant	NA				0.486766151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3477	chr2	7005321	7005341	6865190	6865210	75457	hg19					enhancer	enh				GAGTTCGAGGCCGACCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.554920096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3478	chr2	7005330	7005350	6865199	6865219	75458	hg19					enhancer	enh				GCCTCGAACTCGCCCAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				0.12467252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3479	chr2	7005335	7005356	6865204	6865225	75459	hg19					enhancer	enh				GAACTCGCCCAAGTGCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	direct	Highly Significant	NA				0.529486314									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3480	chr2	7005346	7005366	6865215	6865235	75460	hg19					enhancer	enh				GGAGGCACCACGCCCGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	direct	Highly Significant	NA				0.272355774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3481	chr2	7005379	7005400	6865248	6865269	75461	hg19					enhancer	enh				GCAGCTCGAGCAGCGCTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.0787022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3482	chr2	7005397	7005417	6865266	6865286	75462	hg19					enhancer	enh				GCCGGGTGTCAGGGTCATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.003902521									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3483	chr2	7005433	7005454	6865302	6865323	75463	hg19					enhancer	enh				GGAAGCCTTGCTGTGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.101513561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3484	chr2	7005434	7005454	6865303	6865323	75464	hg19					enhancer	enh				GAAGCCTTGCTGTGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.067740405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3485	chr2	7005437	7005459	6865306	6865328	75465	hg19					enhancer	enh				GCCTTGCTGTGCGCCGCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.065168819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3486	chr2	7005456	7005478	6865325	6865347	75466	hg19					enhancer	enh				GCTACTGCCCGGGCGGCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.168345296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3487	chr2	7005465	7005486	6865334	6865355	75467	hg19					enhancer	enh				GCTGCTCTGCTACTGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.109379328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3488	chr2	7005488	7005509	6865357	6865378	75468	hg19					enhancer	enh				GAGCAGCTGGCACCGCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				0.166644018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3489	chr2	7005488	7005508	6865357	6865377	75469	hg19					enhancer	enh				GAGCAGCTGGCACCGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				0.189086257									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3490	chr2	7005496	7005516	6865365	6865385	75470	hg19					enhancer	enh				GGCACCGCTGGAAGGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.862652701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3491	chr2	7005503	7005525	6865372	6865394	75471	hg19					enhancer	enh				GCTGCGCCGCGGCCCCTTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	direct	Highly Significant	NA				0.221219733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3492	chr2	7005512	7005534	6865381	6865403	75472	hg19					enhancer	enh				GCCGCGGCGCAGCTGGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	direct	Highly Significant	NA				0.314126465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3493	chr2	7005579	7005599	6865448	6865468	75473	hg19					enhancer	enh				GTGCCCGTGACCCCGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CMPK2	indirect	Non Significant	NA				-0.270153649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88309	chr2	8822006	8822026	8681876	8681896	75474	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GTTCGCAGCCAATCCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				-0.022053166	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822056	8822076	8681926	8681946	75475	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCGCTTCCATTGGTGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				0.010119331	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822078	8822098	8681948	8681968	75476	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCACGTCTATCAAGACGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.283945299	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822091	8822112	8681961	8681982	75477	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GACGTGCCACCTTCCGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.420447718	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822110	8822130	8681980	8682000	75478	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GAGCTTCCCTTCGTCCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.334429089	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822115	8822137	8681985	8682007	75479	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GACGAAGGGAAGCTCCAGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				-1.373709981	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822132	8822153	8682002	8682023	75480	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCACTCGCCGGGGCCACACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.216388654	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822149	8822171	8682019	8682041	75481	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GTGCGGATAAAAGCCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.738096756	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822151	8822172	8682021	8682042	75482	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCGGATAAAAGCCGCCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.595079024	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822151	8822171	8682021	8682041	75483	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCGGATAAAAGCCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.43672396	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822168	8822189	8682038	8682059	75484	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GAATGAAGCCCGAGCCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.291965421	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822169	8822189	8682039	8682059	75485	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GAATGAAGCCCGAGCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				0.044884002	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822173	8822194	8682043	8682064	75486	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCTCAGAATGAAGCCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.544795063	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822179	8822200	8682049	8682070	75487	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GGCTTCATTCTGAGCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.67247172	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822180	8822200	8682050	8682070	75488	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCTTCATTCTGAGCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				-0.139362746	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822196	8822216	8682066	8682086	75489	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GCTGCGCTTGGCACCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				0.074105123	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822201	8822222	8682071	8682092	75490	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GAGCTAGCTGCGCTTGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.336570055	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822243	8822264	8682113	8682134	75491	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GAGCTGGCTGCCCTGAAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	indirect	Non Significant	NA				-0.259876135	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-88309	chr2	8822270	8822292	8682140	8682162	75492	hg19	N/A	enh99597	N/A	N/A	enhancer	enh				GACCGCGAGGGAAGGCGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ID2	direct	Highly Significant	NA				0.242332844	ID2	chr2	8678844	8684461	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	235
enhrx-lit3494	chr2	9983469	9983489	9843340	9843360	75493	hg19					enhancer	enh				GGAAAGTTAGGTAGTCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				0.035176801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3495	chr2	9983562	9983582	9843433	9843453	75494	hg19					enhancer	enh				GAAACGCGAGATCCGCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	direct	Highly Significant	NA				0.303503753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3496	chr2	9983566	9983586	9843437	9843457	75495	hg19					enhancer	enh				GCGGATCTCGCGTTTCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.314866648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3497	chr2	9983600	9983620	9843471	9843491	75496	hg19					enhancer	enh				GCGCAGCTTCCGGGAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.589226434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3498	chr2	9983604	9983624	9843475	9843495	75497	hg19					enhancer	enh				GCGAGCGCAGCTTCCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.239127333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3499	chr2	9983609	9983629	9843480	9843500	75498	hg19					enhancer	enh				GGAAGCTGCGCTCGCTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				0.010019464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3500	chr2	9983613	9983635	9843484	9843506	75499	hg19					enhancer	enh				GCTGCGCTCGCTACCCGGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.605805678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3501	chr2	9983616	9983636	9843487	9843507	75500	hg19					enhancer	enh				GCGCTCGCTACCCGGGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.758796947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3502	chr2	9983622	9983642	9843493	9843513	75501	hg19					enhancer	enh				GCTACCCGGGTAACGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.830290612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3503	chr2	9983638	9983660	9843509	9843531	75502	hg19					enhancer	enh				GTCCCGGCTGTGGAAGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.169462868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3504	chr2	9983644	9983664	9843515	9843535	75503	hg19					enhancer	enh				GCCGCGGGAGCTTCCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.104923841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3505	chr2	9983644	9983666	9843515	9843537	75504	hg19					enhancer	enh				GCGCCGCGGGAGCTTCCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.238524506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3506	chr2	9983649	9983671	9843520	9843542	75505	hg19					enhancer	enh				GGAAGCTCCCGCGGCGCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				0.058968633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3507	chr2	9983650	9983671	9843521	9843542	75506	hg19					enhancer	enh				GAAGCTCCCGCGGCGCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	direct	Highly Significant	NA				0.727018343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3508	chr2	9983661	9983683	9843532	9843554	75507	hg19					enhancer	enh				GGCGCCGCGATGGACCTCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.509344088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3509	chr2	9983662	9983683	9843533	9843554	75508	hg19					enhancer	enh				GCGCCGCGATGGACCTCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.250002534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88411	chr2	9983673	9983694	9843544	9843565	75509	hg19	N/A	N/A	N/A	Enhatls94710	enhancer	enh				GACCTCGAGGAGGCGGTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-1.74352867	TAF1B	chr2	9843442	9934416	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	337
enhrx-88411	chr2	9983678	9983698	9843549	9843569	75510	hg19	N/A	N/A	N/A	Enhatls94710	enhancer	enh				GCCTCCTTACCGCCTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				0.076911426	TAF1B	chr2	9843442	9934416	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	337
enhrx-88411	chr2	9983685	9983706	9843556	9843577	75511	hg19	N/A	N/A	N/A	Enhatls94710	enhancer	enh				GCGGTAAGGAGGCGGTGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.014396807	TAF1B	chr2	9843442	9934416	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	337
enhrx-88411	chr2	9983701	9983723	9843572	9843594	75512	hg19	N/A	N/A	N/A	Enhatls94710	enhancer	enh				GCACCTGGCGGGCCACGATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TAF1B	indirect	Non Significant	NA				-0.064690894	TAF1B	chr2	9843442	9934416	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	337
enhrx-lit3510	chr2	10091688	10091708	9951559	9951579	75513	hg19					enhancer	enh				GCTCTTCTCGCCGACCAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				0.065828242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3511	chr2	10091700	10091720	9951571	9951591	75514	hg19					enhancer	enh				GACCAATCAGGAGGCGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.086631397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3512	chr2	10091754	10091775	9951625	9951646	75515	hg19					enhancer	enh				GCTCATTGGCTGGCGATGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.195802255									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3513	chr2	10091786	10091806	9951657	9951677	75516	hg19					enhancer	enh				GGGCTGCGCGCACTGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.250171481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3514	chr2	10091806	10091826	9951677	9951697	75517	hg19					enhancer	enh				GCTCTGAGCCGGCTCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.041427852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3515	chr2	10091828	10091850	9951699	9951721	75518	hg19					enhancer	enh				GAAAAGCAAACCCAACCCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-1.864588882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3516	chr2	10091828	10091849	9951699	9951720	75519	hg19					enhancer	enh				GAAAAGCAAACCCAACCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	direct	Highly Significant	NA				0.94542472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3517	chr2	10091828	10091848	9951699	9951719	75520	hg19					enhancer	enh				GAAAAGCAAACCCAACCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.021315546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3518	chr2	10091842	10091862	9951713	9951733	75521	hg19					enhancer	enh				GAGCGGCGGCCCCGACGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.417611664									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3519	chr2	10091846	10091867	9951717	9951738	75522	hg19					enhancer	enh				GTCCGGAGCGGCGGCCCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	direct	Highly Significant	NA				0.214775425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3520	chr2	10091847	10091867	9951718	9951738	75523	hg19					enhancer	enh				GTCCGGAGCGGCGGCCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	direct	Highly Significant	NA				0.482679367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3521	chr2	10091894	10091914	9951765	9951785	75524	hg19					enhancer	enh				GACAGTACACCCGATCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.7042782									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3522	chr2	10091895	10091915	9951766	9951786	75525	hg19					enhancer	enh				GGACAGTACACCCGATCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				0.091234812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3523	chr2	10091917	10091937	9951788	9951808	75526	hg19					enhancer	enh				GCAGAACTGGACTTTCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				0.10550441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3524	chr2	10091921	10091941	9951792	9951812	75527	hg19					enhancer	enh				GAAAGTCCAGTTCTGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				-0.046967542									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3525	chr2	10091930	10091951	9951801	9951822	75528	hg19					enhancer	enh				GCCGCTGCCGGGCCGCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				0.097051372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3526	chr2	10091949	10091969	9951820	9951840	75529	hg19					enhancer	enh				GCGAGCGGGCGCGATGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GRHL1	indirect	Non Significant	NA				0.002215298									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3527	chr2	10183500	10183521	10043373	10043394	75530	hg19					enhancer	enh				GAGCCTGGCCGCGGCGTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.137225085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3528	chr2	10183509	10183529	10043382	10043402	75531	hg19					enhancer	enh				GCGGCCAGGCTCCGATCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.124822956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3529	chr2	10183516	10183536	10043389	10043409	75532	hg19					enhancer	enh				GGGGCCGCGTGATCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	direct	Highly Significant	NA				0.436064121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3530	chr2	10183538	10183558	10043411	10043431	75533	hg19					enhancer	enh				GGCCGGCCAATGAGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.029157123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3531	chr2	10183551	10183572	10043424	10043445	75534	hg19					enhancer	enh				GCCGGCCGGGCACGAATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.022954079									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3532	chr2	10183721	10183742	10043594	10043615	75535	hg19					enhancer	enh				GCGTGCCGGCCGCAGGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.07921453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3533	chr2	10183723	10183743	10043596	10043616	75536	hg19					enhancer	enh				GTGCCGGCCGCAGGAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.499964218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3534	chr2	10183729	10183751	10043602	10043624	75537	hg19					enhancer	enh				GGCAACCCGGAGCTCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.230346416									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3535	chr2	10183729	10183750	10043602	10043623	75538	hg19					enhancer	enh				GCAACCCGGAGCTCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	direct	Highly Significant	NA				0.341536192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3536	chr2	10183767	10183789	10043640	10043662	75539	hg19					enhancer	enh				GCAGCGGCCGCACGTGGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.462885788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3537	chr2	10183774	10183794	10043647	10043667	75540	hg19					enhancer	enh				GCGCAGCAGCGGCCGCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	direct	Highly Significant	NA				0.284565651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3538	chr2	10183785	10183806	10043658	10043679	75541	hg19					enhancer	enh				GCGTGAGCTCGGGCGCAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.495450123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3539	chr2	10183790	10183810	10043663	10043683	75542	hg19					enhancer	enh				GCGCCCGAGCTCACGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-1.069076118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3540	chr2	10183808	10183828	10043681	10043701	75543	hg19					enhancer	enh				GGAGCAACAAAGCGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.088042141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3541	chr2	10183816	10183836	10043689	10043709	75544	hg19					enhancer	enh				GCCGGCCGGGAGCAACAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	direct	Highly Significant	NA				0.224505959									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3542	chr2	10183833	10183853	10043706	10043726	75545	hg19					enhancer	enh				GGCCTGCACGATGCACACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.165621479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3543	chr2	10183838	10183858	10043711	10043731	75546	hg19					enhancer	enh				GTCCGGCGTGTGCATCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.012330677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3544	chr2	10183855	10183876	10043728	10043749	75547	hg19					enhancer	enh				GTCGTCTGGGCCTGCGAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				-0.448666169									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3545	chr2	10183870	10183890	10043743	10043763	75548	hg19					enhancer	enh				GACGACGCGCGCGCAGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KLF11	indirect	Non Significant	NA				0.068871211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88512	chr2	10952791	10952811	10812665	10812685	75549	hg19	N/A	N/A	N/A	Enhatls94820	enhancer	enh				GCCCGCACCTACCGAGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.052491887	PDIA6	chr2	10783390	10837977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	438
enhrx-lit3546	chr2	10952812	10952832	10812686	10812706	75550	hg19					enhancer	enh				GGAGAGCCATGCCGAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	direct	Highly Significant	NA				0.25852203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3547	chr2	10952812	10952832	10812686	10812706	75551	hg19					enhancer	enh				GGCGCTCGGCATGGCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.143820266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3548	chr2	10952821	10952843	10812695	10812717	75552	hg19					enhancer	enh				GCACGTAGCCCGGCGCTCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.415848184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3549	chr2	10952826	10952848	10812700	10812722	75553	hg19					enhancer	enh				GGACTGCACGTAGCCCGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.337273306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3550	chr2	10952826	10952847	10812700	10812721	75554	hg19					enhancer	enh				GACTGCACGTAGCCCGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				0.042870973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3551	chr2	10952833	10952853	10812707	10812727	75555	hg19					enhancer	enh				GGTGGGGACTGCACGTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.028808582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3552	chr2	10952833	10952855	10812707	10812729	75556	hg19					enhancer	enh				GCGGTGGGGACTGCACGTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.27185643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3553	chr2	10952860	10952882	10812734	10812756	75557	hg19					enhancer	enh				GCACGCTGCAGGGCTGAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.179779495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3554	chr2	10952863	10952883	10812737	10812757	75558	hg19					enhancer	enh				GGCACGCTGCAGGGCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.213829812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3555	chr2	10952872	10952894	10812746	10812768	75559	hg19					enhancer	enh				GCGCGGCGTGCGGCACGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.015767008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3556	chr2	10952872	10952892	10812746	10812766	75560	hg19					enhancer	enh				GCGGCGTGCGGCACGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDIA6	indirect	Non Significant	NA				-0.813517475									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88608	chr2	11886573	11886593	11746447	11746467	75561	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GAACGCTAAGATAGGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	direct	Highly Significant	NA				0.873253531	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886719	11886740	11746593	11746614	75562	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GTCAGCGCAGCTCGCCTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.186042028	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886724	11886746	11746598	11746620	75563	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GGCGAGCTGCGCTGACAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.728379247	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886725	11886746	11746599	11746620	75564	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCGAGCTGCGCTGACAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.358501383	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886729	11886749	11746603	11746623	75565	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCTGCGCTGACAGCCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.297353628	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886734	11886755	11746608	11746629	75566	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCTGACAGCCGGCGGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.038289498	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886745	11886765	11746619	11746639	75567	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCAAACACCCAGCCCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.102434382	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886751	11886772	11746625	11746646	75568	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GGCTGGGTGTTTGCAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.069336952	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886752	11886772	11746626	11746646	75569	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCTGGGTGTTTGCAATACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.164872827	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886763	11886785	11746637	11746659	75570	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GCAATACAAAGGCGGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.49005797	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886793	11886813	11746667	11746687	75571	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GGCGGCGGCTACTCACCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.610713416	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886793	11886813	11746667	11746687	75572	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GGCGGCGGCTACTCACCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.610713416	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886793	11886815	11746667	11746689	75573	hg19	N/A	enh5290	N/A	N/A	enhancer	enh				GAGGCGGCGGCTACTCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.064003462	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886793	11886815	11746667	11746689	75574	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GAGGCGGCGGCTACTCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.064003462	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886807	11886828	11746681	11746702	75575	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GCCGCCTCCAGCCTCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.161181315	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886814	11886834	11746688	11746708	75576	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GCTCCACAGCGGGAGGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-1.661149223	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886821	11886841	11746695	11746715	75577	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GGCCCCTGCTCCACAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				0.00777923	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886827	11886848	11746701	11746722	75578	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GTGGAGCAGGGGCCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.308339512	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886838	11886858	11746712	11746732	75579	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GCCGCAGCCTCGGGTTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.205135535	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886848	11886868	11746722	11746742	75580	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GCCCCGCCCCGCCTAACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.635618245	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-88608	chr2	11886930	11886950	11746804	11746824	75581	hg19	N/A	enh5290	N/A	Enhatls94924	enhancer	enh				GACGGCCGGGCTACGTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LPIN1	indirect	Non Significant	NA				-0.4898186	LPIN1	chr2	11677594	11827409	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	534
enhrx-lit3557	chr2	12856871	12856891	12716745	12716765	75582	hg19					enhancer	enh				GAGCTGCAATGGCAGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.242435959									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3558	chr2	12856890	12856910	12716764	12716784	75583	hg19					enhancer	enh				GCGGGGAGCCGCCCGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.530346951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3559	chr2	12856920	12856940	12716794	12716814	75584	hg19					enhancer	enh				GGGGCTGATTGATGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	direct	Highly Significant	NA				0.940878972									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3560	chr2	12856930	12856950	12716804	12716824	75585	hg19					enhancer	enh				GATGGGCGCCCGGCGCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.183897218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3561	chr2	12856982	12857004	12716856	12716878	75586	hg19					enhancer	enh				GCTCTGGGCTGAGCCAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.305906829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3562	chr2	12857035	12857057	12716909	12716931	75587	hg19					enhancer	enh				GAAATGTGTCGGTGACATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.126119189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3563	chr2	12857068	12857088	12716942	12716962	75588	hg19					enhancer	enh				GCGCGCGCCTCGCTCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.095522874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3564	chr2	12857084	12857105	12716958	12716979	75589	hg19					enhancer	enh				GCGCGCGCACACGCGCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.129268947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3565	chr2	12857107	12857129	12716981	12717003	75590	hg19					enhancer	enh				GCCCCGCTCGCTCCGAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				0.024972471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3566	chr2	12857112	12857134	12716986	12717008	75591	hg19					enhancer	enh				GGCCGGGGATCTCGGAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.16889351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3567	chr2	12857112	12857133	12716986	12717007	75592	hg19					enhancer	enh				GCCGGGGATCTCGGAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.062731843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3568	chr2	12857135	12857157	12717009	12717031	75593	hg19					enhancer	enh				GCGGTATTAATAGTTACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-1.536400708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3569	chr2	12857140	12857162	12717014	12717036	75594	hg19					enhancer	enh				GTAACTATTAATACCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.030499364									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3570	chr2	12857167	12857188	12717041	12717062	75595	hg19					enhancer	enh				GATGCGGGCGTGCTGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.000695343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3571	chr2	12857178	12857199	12717052	12717073	75596	hg19					enhancer	enh				GCTGAGCGCGGGGATTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	direct	Highly Significant	NA				0.202929059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3572	chr2	12857189	12857209	12717063	12717083	75597	hg19					enhancer	enh				GGATTGGCCTCGGGCACCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.015651084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3573	chr2	12857199	12857219	12717073	12717093	75598	hg19					enhancer	enh				GGGACGGCCGACGGTGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRIB2	indirect	Non Significant	NA				-0.052998126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3574	chr2	17934889	17934910	17753622	17753643	75599	hg19					enhancer	enh				GACTTCGACTTGTTGGCGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.613214739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3575	chr2	17934929	17934950	17753662	17753683	75600	hg19					enhancer	enh				GCGGGGCTGCCGTGGTACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.162879379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3576	chr2	17934937	17934959	17753670	17753692	75601	hg19					enhancer	enh				GCCGTGGTACGACCGGCCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				0.162789966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3577	chr2	17934969	17934989	17753702	17753722	75602	hg19					enhancer	enh				GCCGAGGTCGAGACGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.700562722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3578	chr2	17934985	17935005	17753718	17753738	75603	hg19					enhancer	enh				GGGCCAGCGGCGGTCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.579332685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3579	chr2	17935006	17935026	17753739	17753759	75604	hg19					enhancer	enh				GGCCGGCACGCGGTTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-1.062301503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3580	chr2	17935007	17935028	17753740	17753761	75605	hg19					enhancer	enh				GCGGCCGGCACGCGGTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.613040134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3581	chr2	17935023	17935045	17753756	17753778	75606	hg19					enhancer	enh				GGAATCTACCTTCTCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.712154708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3582	chr2	17935023	17935044	17753756	17753777	75607	hg19					enhancer	enh				GAATCTACCTTCTCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.738729373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3583	chr2	17935032	17935054	17753765	17753787	75608	hg19					enhancer	enh				GAAGGTAGATTCCCGGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	direct	Highly Significant	NA				0.230355892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3584	chr2	17935056	17935077	17753789	17753810	75609	hg19					enhancer	enh				GGTTAGTACCGCGGTGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-2.892997269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3585	chr2	17935056	17935076	17753789	17753809	75610	hg19					enhancer	enh				GTTAGTACCGCGGTGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-1.062564447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3586	chr2	17935062	17935082	17753795	17753815	75611	hg19					enhancer	enh				GGCGCGGTTAGTACCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	direct	Highly Significant	NA				0.212513084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3587	chr2	17935063	17935085	17753796	17753818	75612	hg19					enhancer	enh				GCAGGCGCGGTTAGTACCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	direct	Highly Significant	NA				0.519468853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3588	chr2	17935066	17935087	17753799	17753820	75613	hg19					enhancer	enh				GCGCAGGCGCGGTTAGTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				-0.725090352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3589	chr2	17935122	17935142	17753855	17753875	75614	hg19					enhancer	enh				GCGAAACCCCGCAACTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				0.086520868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3590	chr2	17935127	17935147	17753860	17753880	75615	hg19					enhancer	enh				GTTGCGGGGTTTCGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	indirect	Non Significant	NA				0.195959611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3591	chr2	17935206	17935226	17753939	17753959	75616	hg19					enhancer	enh				GGCTCCGCAGTGACCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMC6	direct	Highly Significant	NA				0.660276859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-88811	chr2	20101221	20101241	19901460	19901480	75617	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GAAATCTCTCCGCACCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.334700609	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101233	20101254	19901472	19901493	75618	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GAGCCAGCTGCCGCGACGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.060707697	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101256	20101277	19901495	19901516	75619	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCGGGGAGAAGCCCACCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.439738787	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101292	20101314	19901531	19901553	75620	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GGCCTAGGCGAGGCCTAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.526839595	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101298	20101318	19901537	19901557	75621	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GAAAGGCCTAGGCGAGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.431683659	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101309	20101331	19901548	19901570	75622	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GTTCGTCTTTCTAGAAAGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.002186179	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101315	20101335	19901554	19901574	75623	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GGACGTTCGTCTTTCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.518440821	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101315	20101337	19901554	19901576	75624	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCGGACGTTCGTCTTTCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.533021282	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101349	20101369	19901588	19901608	75625	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCTTGTCATAACCCAGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.338916005	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101349	20101371	19901588	19901610	75626	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCGCTTGTCATAACCCAGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.200579138	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101367	20101387	19901606	19901626	75627	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCGCCGACCGTGAGCTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				0.152056293	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101376	20101397	19901615	19901636	75628	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GTGAGCTCCAGAGGCAAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.303493152	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101416	20101437	19901655	19901676	75629	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GACCCCGGGTGGAGGCGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	direct	Highly Significant	NA				0.2698666	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101421	20101441	19901660	19901680	75630	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GCCTCCACCCGGGGTCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				0.193801891	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101432	20101453	19901671	19901692	75631	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GACCTGGGGCCGCGGCGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.138048289	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-88811	chr2	20101449	20101469	19901688	19901708	75632	hg19	N/A	N/A	N/A	Enhatls95147	enhancer	enh				GAGGTAACTATCGCGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-0.424426731	TTC32	chr2	19896630	19901983	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	737
enhrx-lit3592	chr2	20101472	20101492	19901711	19901731	75633	hg19					enhancer	enh				GCCTCCAGCGACGAGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				0.086828841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3593	chr2	20101513	20101533	19901752	19901772	75634	hg19					enhancer	enh				GTAAGCGGAGTACAGTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC32	indirect	Non Significant	NA				-1.105400472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3594	chr2	20189758	20189778	19989997	19990017	75635	hg19					enhancer	enh				GCTCAGGTAGAAGAACATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.0568812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3595	chr2	20189770	20189791	19990009	19990030	75636	hg19					enhancer	enh				GAACATCGTGGGATCCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.067664772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3596	chr2	20189788	20189810	19990027	19990049	75637	hg19					enhancer	enh				GAGAGGGTCACGGCGGCCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.02885207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3597	chr2	20189790	20189810	19990029	19990049	75638	hg19					enhancer	enh				GAGGGTCACGGCGGCCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	direct	Highly Significant	NA				0.392078686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3598	chr2	20189806	20189827	19990045	19990066	75639	hg19					enhancer	enh				GCTAAGGCCCTCGACAAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	direct	Highly Significant	NA				0.322117427									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3599	chr2	20189816	20189836	19990055	19990075	75640	hg19					enhancer	enh				GTAGAACCGTTACTTGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.383273342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3600	chr2	20189817	20189839	19990056	19990078	75641	hg19					enhancer	enh				GACGTAGAACCGTTACTTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.033518982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3601	chr2	20189823	20189845	19990062	19990084	75642	hg19					enhancer	enh				GTAACGGTTCTACGTCTCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.145676073									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3602	chr2	20189843	20189864	19990082	19990103	75643	hg19					enhancer	enh				GGAGCTGCTGGTACTCCCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.037921858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3603	chr2	20189843	20189863	19990082	19990102	75644	hg19					enhancer	enh				GAGCTGCTGGTACTCCCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	direct	Highly Significant	NA				0.284614665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3604	chr2	20189856	20189878	19990095	19990117	75645	hg19					enhancer	enh				GACGGGAGCTTTCCGGAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	direct	Highly Significant	NA				1.053136914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3605	chr2	20189876	20189898	19990115	19990137	75646	hg19					enhancer	enh				GCAACAGCGGTTGCCAGGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.1248744									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3606	chr2	20189878	20189899	19990117	19990138	75647	hg19					enhancer	enh				GCCCTGGCAACCGCTGTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.142927728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3607	chr2	20189882	20189904	19990121	19990143	75648	hg19					enhancer	enh				GACCGGGCAACAGCGGTTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.312219804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3608	chr2	20189883	20189904	19990122	19990143	75649	hg19					enhancer	enh				GACCGGGCAACAGCGGTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				0.155706725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3609	chr2	20189890	20189911	19990129	19990150	75650	hg19					enhancer	enh				GCTGTTGCCCGGTCGCATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	direct	Highly Significant	NA				0.213237874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3610	chr2	20189890	20189910	19990129	19990149	75651	hg19					enhancer	enh				GCTGTTGCCCGGTCGCATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.111421236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3611	chr2	20189956	20189977	19990195	19990216	75652	hg19					enhancer	enh				GTCCGCGCAGGCGCACTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.48853591									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3612	chr2	20189963	20189983	19990202	19990222	75653	hg19					enhancer	enh				GCGCCTGCGCGGACGTCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR35	indirect	Non Significant	NA				-0.118511778									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3613	chr2	20251230	20251250	20051469	20051489	75654	hg19					enhancer	enh				GTGACCGGTTCTACAGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	direct	Highly Significant	NA				0.291211201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3614	chr2	20251251	20251271	20051490	20051510	75655	hg19					enhancer	enh				GCGGTTCCGCTTGAAACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.036861397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3615	chr2	20251260	20251282	20051499	20051521	75656	hg19					enhancer	enh				GATGGTGTCCATGAGTTTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.128663175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3616	chr2	20251280	20251302	20051519	20051541	75657	hg19					enhancer	enh				GAAGGAGGCCCGCCTGTTACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	direct	Highly Significant	NA				0.333211404									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3617	chr2	20251309	20251330	20051548	20051569	75658	hg19					enhancer	enh				GGAGAACGTTTGTCAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.190718061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3618	chr2	20251309	20251329	20051548	20051568	75659	hg19					enhancer	enh				GAGAACGTTTGTCAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.795680875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3619	chr2	20251314	20251334	20051553	20051573	75660	hg19					enhancer	enh				GGGTGGAGAACGTTTGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.030513369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3620	chr2	20251315	20251336	20051554	20051575	75661	hg19					enhancer	enh				GCGGGTGGAGAACGTTTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	direct	Highly Significant	NA				0.599791453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3621	chr2	20251331	20251353	20051570	20051592	75662	hg19					enhancer	enh				GCCGTTTGAGTTTGGCTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.553192323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3622	chr2	20251378	20251400	20051617	20051639	75663	hg19					enhancer	enh				GACGCGTCTTCAAACCCGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.066746629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3623	chr2	20251400	20251420	20051639	20051659	75664	hg19					enhancer	enh				GCTGGCAGGGGCACGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.159436893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3624	chr2	20251402	20251423	20051641	20051662	75665	hg19					enhancer	enh				GAAGCTGGCAGGGGCACGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.954768373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3625	chr2	20251413	20251434	20051652	20051673	75666	hg19					enhancer	enh				GCAGGCGCGAAGAAGCTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	direct	Highly Significant	NA				1.38650699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3626	chr2	20251414	20251434	20051653	20051673	75667	hg19					enhancer	enh				GCAGGCGCGAAGAAGCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.031346499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3627	chr2	20251418	20251438	20051657	20051677	75668	hg19					enhancer	enh				GTGCGCAGGCGCGAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.642128448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3628	chr2	20251432	20251454	20051671	20051693	75669	hg19					enhancer	enh				GAAGTCGCTGCGCTCAGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				0.065745416									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3629	chr2	20251552	20251574	20051791	20051813	75670	hg19					enhancer	enh				GTTGCACTTCTAATTGGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	direct	Highly Significant	NA				0.276630478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3630	chr2	20251584	20251605	20051823	20051844	75671	hg19					enhancer	enh				GAGTCTCCGCCTGTTACGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.112434598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3631	chr2	20251593	20251615	20051832	20051854	75672	hg19					enhancer	enh				GCCCTTGCCTTCGCGTAACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LAPTM4A	indirect	Non Significant	NA				-0.56893418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3632	chr2	24307144	24307165	24084274	24084295	75673	hg19					enhancer	enh				GACCGGAAAACCTCTACGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				0.137330369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3633	chr2	24307167	24307187	24084297	24084317	75674	hg19					enhancer	enh				GTGCACTTTGACAAGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	direct	Highly Significant	NA				1.006046158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3634	chr2	24307283	24307305	24084413	24084435	75675	hg19					enhancer	enh				GGCAGGGGCCGCTGTATCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				0.148928975									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3635	chr2	24307284	24307305	24084414	24084435	75676	hg19					enhancer	enh				GCAGGGGCCGCTGTATCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.030282422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3636	chr2	24307294	24307314	24084424	24084444	75677	hg19					enhancer	enh				GCTGCTCCGCGAGGATACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.328407748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3637	chr2	24307294	24307315	24084424	24084445	75678	hg19					enhancer	enh				GGCTGCTCCGCGAGGATACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.164357579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3638	chr2	24307304	24307326	24084434	24084456	75679	hg19					enhancer	enh				GCGGAGCAGCCCAGCCTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	direct	Highly Significant	NA				0.465942081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3639	chr2	24307306	24307326	24084436	24084456	75680	hg19					enhancer	enh				GGAGCAGCCCAGCCTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.177072506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3640	chr2	24307316	24307338	24084446	24084468	75681	hg19					enhancer	enh				GCTGCGGTGCCAGCCTGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.189401369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3641	chr2	24307321	24307341	24084451	24084471	75682	hg19					enhancer	enh				GGCGCTGCGGTGCCAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.001846039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3642	chr2	24307321	24307342	24084451	24084472	75683	hg19					enhancer	enh				GGGCGCTGCGGTGCCAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.122219503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3643	chr2	24307344	24307365	24084474	24084495	75684	hg19					enhancer	enh				GCAGCGAGGCGCTGGCCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.077437283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3644	chr2	24307367	24307387	24084497	24084517	75685	hg19					enhancer	enh				GCCGGGTCCGCGGCAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				0.020462479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3645	chr2	24307418	24307438	24084548	24084568	75686	hg19					enhancer	enh				GATCGGTCTGGAGGCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				0.021629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3646	chr2	24307423	24307443	24084553	24084573	75687	hg19					enhancer	enh				GCCTCCAGACCGATCCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	direct	Highly Significant	NA				0.400050927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3647	chr2	24307430	24307451	24084560	24084581	75688	hg19					enhancer	enh				GTGTTCCGGGTGGGATCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	direct	Highly Significant	NA				0.783779838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3648	chr2	24307440	24307461	24084570	24084591	75689	hg19					enhancer	enh				GTTCCCATCTGTGTTCCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.117012776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3649	chr2	24307465	24307485	24084595	24084615	75690	hg19					enhancer	enh				GGAAGTGGGATGGCGGTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	indirect	Non Significant	NA				-0.069335803									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3650	chr2	24307497	24307519	24084627	24084649	75691	hg19					enhancer	enh				GCAGAGCAGGACAACGCCGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TP53I3	direct	Highly Significant	NA				0.495251229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-89044	chr2	24713964	24713984	24491095	24491115	75692	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GGGCGCACTGTCGGAGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.021740106	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24713977	24713998	24491108	24491129	75693	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GAGCTCGCGGGCACCGGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.095008274	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714134	24714154	24491265	24491285	75694	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GGCCGAGGAGGAGAACATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.20608608	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714140	24714160	24491271	24491291	75695	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GGAGGAGAACATGGCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.243704247	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714146	24714167	24491277	24491298	75696	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GAACATGGCGGCCGCGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.102204921	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714160	24714180	24491291	24491311	75697	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GGCATTTCAGCCGCTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.260555721	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714172	24714193	24491303	24491324	75698	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GAAATGCCTGTTCTTCAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.152775689	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714172	24714192	24491303	24491323	75699	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GAAATGCCTGTTCTTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.099168918	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714181	24714201	24491312	24491332	75700	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GCTCGCCCGGCCTGAAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.203340807	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714181	24714201	24491312	24491332	75701	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GTTCTTCAGGCCGGGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.052187582	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714194	24714214	24491325	24491345	75702	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GCGTCAGACTCCCGCTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.174599884	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714229	24714249	24491360	24491380	75703	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GTCCTCCGACGGCTGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.076022261	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714234	24714254	24491365	24491385	75704	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GGCCGCGAGGCAGCCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.151865303	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714247	24714268	24491378	24491399	75705	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GCGGAGGCCCTCAAGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	direct	Highly Significant	NA				0.347915269	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714267	24714287	24491398	24491418	75706	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GAGCAGCAGCGAACAGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				-0.410015019	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714273	24714295	24491404	24491426	75707	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GCTCGAGGGAGCAGCAGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	indirect	Non Significant	NA				0.036245527	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-89044	chr2	24714302	24714323	24491433	24491454	75708	hg19	N/A	N/A	N/A	Enhatls95391	enhancer	enh				GATGCAGAGGGAACCTGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCOA1	direct	Highly Significant	NA				0.336865682	NCOA1	chr2	24491253	24770702	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	970
enhrx-lit3651	chr2	25016218	25016238	24793349	24793369	75709	hg19					enhancer	enh				GAAAGGCCGGACCTACTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.654598905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3652	chr2	25016227	25016247	24793358	24793378	75710	hg19					enhancer	enh				GATGCACCGGGGAGTAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	direct	Highly Significant	NA				0.549450434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3653	chr2	25016238	25016260	24793369	24793391	75711	hg19					enhancer	enh				GCCCTGATCCCAAGATGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	direct	Highly Significant	NA				0.302070238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3654	chr2	25016268	25016290	24793399	24793421	75712	hg19					enhancer	enh				GTACAAAAGCATGGCGGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	direct	Highly Significant	NA				0.373546059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3655	chr2	25016294	25016316	24793425	24793447	75713	hg19					enhancer	enh				GGATCGCAAAGCACGCCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.377475952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3656	chr2	25016347	25016367	24793478	24793498	75714	hg19					enhancer	enh				GGGAATTCTCGCTTCTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.18404926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3657	chr2	25016370	25016391	24793501	24793522	75715	hg19					enhancer	enh				GTGAGCTAGAAGGGAGAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	direct	Highly Significant	NA				0.482830684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3658	chr2	25016405	25016426	24793536	24793557	75716	hg19					enhancer	enh				GGCCACGGTCCGGTCCGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.270174419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3659	chr2	25016405	25016425	24793536	24793556	75717	hg19					enhancer	enh				GCCACGGTCCGGTCCGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.373295667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3660	chr2	25016410	25016430	24793541	24793561	75718	hg19					enhancer	enh				GGACCGGACCGTGGCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	direct	Highly Significant	NA				0.953396706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3661	chr2	25016416	25016438	24793547	24793569	75719	hg19					enhancer	enh				GCCCGCCACCCTGGCCACGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				0.031605065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3662	chr2	25016427	25016447	24793558	24793578	75720	hg19					enhancer	enh				GGCCGTTCAGCCCGCCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-1.792815914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3663	chr2	25016461	25016481	24793592	24793612	75721	hg19					enhancer	enh				GCGGGCTTCCCGGCCACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.979192708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3664	chr2	25016475	25016497	24793606	24793628	75722	hg19					enhancer	enh				GCCCGCTGGACCAGAGTAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				0.07240121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3665	chr2	25016483	25016503	24793614	24793634	75723	hg19					enhancer	enh				GACCAGAGTAGCCGTGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.276734348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3666	chr2	25016488	25016510	24793619	24793641	75724	hg19					enhancer	enh				GCTCCCGAGGCCACGGCTACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				-0.512080904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3667	chr2	25016493	25016514	24793624	24793645	75725	hg19					enhancer	enh				GCCGTGGCCTCGGGAGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPO	indirect	Non Significant	NA				0.046021147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-89130	chr2	25475079	25475099	25252210	25252230	75726	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCCCTCTGCAGTCGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	direct	Highly Significant	NA				0.212124815	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475090	25475111	25252221	25252242	75727	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GTCGCGCTCAGGTGTGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.035563927	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475237	25475257	25252368	25252388	75728	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GTCTAGGACTCCAGGTCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				0.159966214	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475237	25475258	25252368	25252389	75729	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GTCTAGGACTCCAGGTCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				0.044149419	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475250	25475271	25252381	25252402	75730	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GGTCACGTGGGCCCCGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.444096383	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475250	25475270	25252381	25252401	75731	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GGTCACGTGGGCCCCGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	direct	Highly Significant	NA				0.2453086	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475251	25475271	25252382	25252402	75732	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GTCACGTGGGCCCCGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.132399477	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475256	25475276	25252387	25252407	75733	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GTGGGCCCCGCTGGAGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.036164134	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475264	25475284	25252395	25252415	75734	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCAACCAGGCCCTCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.043172946	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475273	25475295	25252404	25252426	75735	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCTGGTTGGCTGCGAGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.214683694	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475277	25475297	25252408	25252428	75736	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GGTTGGCTGCGAGCGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				0.145414933	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475308	25475328	25252439	25252459	75737	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GGCGCTCCGACGCTGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				0.068874174	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475334	25475354	25252465	25252485	75738	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCCCTCTTCTCCGGTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	direct	Highly Significant	NA				0.393434265	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475340	25475361	25252471	25252492	75739	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCGCCCCTCGGACCGGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				0.106285765	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475377	25475398	25252508	25252529	75740	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCGTTCCCCGCCCGTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	direct	Highly Significant	NA				0.53522581	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-89130	chr2	25475432	25475454	25252563	25252585	75741	hg19	N/A	enh18354	N/A	N/A	enhancer	enh				GCCAGGCGGTCTTCCCGAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNMT3A	indirect	Non Significant	NA				-0.285579647	DNMT3A	chr2	25227854	25342590	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1056
enhrx-lit3668	chr2	26256944	26256964	26034075	26034095	75742	hg19					enhancer	enh				GCTGCCTGAGACGCACGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.226750311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3669	chr2	26256944	26256966	26034075	26034097	75743	hg19					enhancer	enh				GCGCTGCCTGAGACGCACGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.005180801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3670	chr2	26256950	26256972	26034081	26034103	75744	hg19					enhancer	enh				GCGTCTCAGGCAGCGCGCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				0.035103325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3671	chr2	26256952	26256972	26034083	26034103	75745	hg19					enhancer	enh				GTCTCAGGCAGCGCGCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.644712124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3672	chr2	26256959	26256981	26034090	26034112	75746	hg19					enhancer	enh				GCAGCGCGCACGCCGGCGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.170238567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3673	chr2	26256962	26256982	26034093	26034113	75747	hg19					enhancer	enh				GCGCGCACGCCGGCGTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.418064671									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3674	chr2	26256966	26256988	26034097	26034119	75748	hg19					enhancer	enh				GCACGCCGGCGTGAGAGGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.454476863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3675	chr2	26256983	26257004	26034114	26034135	75749	hg19					enhancer	enh				GGCACGGGGAAAAGGTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				0.18022241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3676	chr2	26256984	26257004	26034115	26034135	75750	hg19					enhancer	enh				GCACGGGGAAAAGGTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.757501043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3677	chr2	26256990	26257010	26034121	26034141	75751	hg19					enhancer	enh				GGAAAAGGTGGCTCTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				0.066116206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3678	chr2	26257006	26257028	26034137	26034159	75752	hg19					enhancer	enh				GCCGGGGTGGCTCGGTTTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	direct	Highly Significant	NA				0.455721452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3679	chr2	26257010	26257032	26034141	26034163	75753	hg19					enhancer	enh				GCCCCAGGAAACCGAGCCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.297033087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3680	chr2	26257027	26257047	26034158	26034178	75754	hg19					enhancer	enh				GAGCTCAGTTACATAGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RAB10	indirect	Non Significant	NA				-0.079756077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3681	chr2	27008806	27008828	26785938	26785960	75755	hg19					enhancer	enh				GCCCCTTACGTAGAGCGACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.654870362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3682	chr2	27008834	27008855	26785966	26785987	75756	hg19					enhancer	enh				GAGTCAGCCACTGGGAGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.343632631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3683	chr2	27008895	27008917	26786027	26786049	75757	hg19					enhancer	enh				GAGCGAGCGATTTGAACGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.075018162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3684	chr2	27008897	27008917	26786029	26786049	75758	hg19					enhancer	enh				GCGAGCGATTTGAACGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.251504071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3685	chr2	27008901	27008922	26786033	26786054	75759	hg19					enhancer	enh				GCGATTTGAACGCGAGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.282247968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3686	chr2	27008918	27008940	26786050	26786072	75760	hg19					enhancer	enh				GGCGCGGACTTCTGCCAAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.596869286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3687	chr2	27008919	27008940	26786051	26786072	75761	hg19					enhancer	enh				GCGCGGACTTCTGCCAAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.35909587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3688	chr2	27008936	27008958	26786068	26786090	75762	hg19					enhancer	enh				GCACCGGCTCATGTGAGGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.857488902									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3689	chr2	27008942	27008964	26786074	26786096	75763	hg19					enhancer	enh				GTGCCGCGAGCCTCACATGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.477015211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3690	chr2	27008942	27008962	26786074	26786094	75764	hg19					enhancer	enh				GCCGCGAGCCTCACATGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.45185569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3691	chr2	27008987	27009009	26786119	26786141	75765	hg19					enhancer	enh				GCCAGCCTTTCGCTCCCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.877877859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3692	chr2	27008995	27009016	26786127	26786148	75766	hg19					enhancer	enh				GCTGCCGGGTCCGGGAGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.695315017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3693	chr2	27009011	27009031	26786143	26786163	75767	hg19					enhancer	enh				GCAGCCCGAGCAGGAGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-2.586844753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3694	chr2	27009030	27009050	26786162	26786182	75768	hg19					enhancer	enh				GGTGCTGGCGCCCGGTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-3.549480536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3695	chr2	27009045	27009065	26786177	26786197	75769	hg19					enhancer	enh				GCACCCTCTGCGGCGTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-0.577936467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3696	chr2	27009051	27009071	26786183	26786203	75770	hg19					enhancer	enh				GGCCCATGACACGCCGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.146108019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3697	chr2	27009059	27009079	26786191	26786211	75771	hg19					enhancer	enh				GTGTCATGGGCCCGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.58020429									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3698	chr2	27009074	27009095	26786206	26786227	75772	hg19					enhancer	enh				GCCGCCGGAGCCGAAAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.557741793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3699	chr2	27009081	27009101	26786213	26786233	75773	hg19					enhancer	enh				GGGCCTCGGGCTTTCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CENPA	indirect	Non Significant	NA				-1.854234355									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3700	chr2	27255791	27255812	27032923	27032944	75774	hg19					enhancer	enh				GCGCGGTCCTGCGAGGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-0.065394135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3701	chr2	27255801	27255823	27032933	27032955	75775	hg19					enhancer	enh				GCACTCTGCCACGTCTCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				0.1487762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3702	chr2	27255814	27255836	27032946	27032968	75776	hg19					enhancer	enh				GCAGAGTGCGGCGCGCTCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	direct	Highly Significant	NA				0.357537498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3703	chr2	27255828	27255850	27032960	27032982	75777	hg19					enhancer	enh				GCTCGCGCCGGACCGGAAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	direct	Highly Significant	NA				0.620811882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3704	chr2	27255828	27255849	27032960	27032981	75778	hg19					enhancer	enh				GCTCGCGCCGGACCGGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-0.217126795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3705	chr2	27255837	27255857	27032969	27032989	75779	hg19					enhancer	enh				GGACCGGAAAGCCGGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-2.692667761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3706	chr2	27255843	27255863	27032975	27032995	75780	hg19					enhancer	enh				GAAAGCCGGGGAAGTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-0.013150731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3707	chr2	27255876	27255896	27033008	27033028	75781	hg19					enhancer	enh				GCGAGCCATGGCGACCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	direct	Highly Significant	NA				0.361870437									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3708	chr2	27255878	27255899	27033010	27033031	75782	hg19					enhancer	enh				GAGCCATGGCGACCAAGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-0.146799647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3709	chr2	27255884	27255904	27033016	27033036	75783	hg19					enhancer	enh				GCCCGCCGTCTTGGTCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				0.025623762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3710	chr2	27255886	27255906	27033018	27033038	75784	hg19					enhancer	enh				GCGACCAAGACGGCGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	indirect	Non Significant	NA				-0.347127819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3711	chr2	27255922	27255943	27033054	27033075	75785	hg19					enhancer	enh				GTGAAGAAGGGTCGGCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM214	direct	Highly Significant	NA				0.423653383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3712	chr2	27274357	27274378	27051489	27051510	75786	hg19					enhancer	enh				GAAGACGCTGCTAGAACCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.052027652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3713	chr2	27274397	27274418	27051529	27051550	75787	hg19					enhancer	enh				GCGAGTGTCGTTCGGGGACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.777298767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3714	chr2	27274447	27274468	27051579	27051600	75788	hg19					enhancer	enh				GCTACCATTGGTCAGCTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.322189455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3715	chr2	27274460	27274482	27051592	27051614	75789	hg19					enhancer	enh				GCCCAGTAAAGCTCGCTACCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.245508556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3716	chr2	27274487	27274509	27051619	27051641	75790	hg19					enhancer	enh				GCCAGCTGCAGCCACGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				0.174886862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3717	chr2	27274501	27274523	27051633	27051655	75791	hg19					enhancer	enh				GAAGTCTCTCGCCTATTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				0.096235288									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3718	chr2	27274517	27274539	27051649	27051671	75792	hg19					enhancer	enh				GACTTCTTGTTTCCTGGCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	direct	Highly Significant	NA				0.262681988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3719	chr2	27274525	27274547	27051657	27051679	75793	hg19					enhancer	enh				GTTTCCTGGCAGAGCGGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.939304782									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3720	chr2	27274532	27274553	27051664	27051685	75794	hg19					enhancer	enh				GTGCCGGGACCCCGCTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	direct	Highly Significant	NA				0.260425639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3721	chr2	27274533	27274555	27051665	27051687	75795	hg19					enhancer	enh				GCAGAGCGGGGTCCCGGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				0.078146677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3722	chr2	27274542	27274563	27051674	27051695	75796	hg19					enhancer	enh				GGTCCCGGCACCGCGGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				0.167992136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3723	chr2	27274543	27274563	27051675	27051695	75797	hg19					enhancer	enh				GTCCCGGCACCGCGGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.025062456									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3724	chr2	27274595	27274615	27051727	27051747	75798	hg19					enhancer	enh				GCACCTTGGGCCCCGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.166840782									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3725	chr2	27274604	27274626	27051736	27051758	75799	hg19					enhancer	enh				GCCCAAGGTGCGGCCTCGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.584380874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3726	chr2	27274611	27274632	27051743	27051764	75800	hg19					enhancer	enh				GTGCGGCCTCGCTAGCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.365751672									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3727	chr2	27274613	27274633	27051745	27051765	75801	hg19					enhancer	enh				GCGGCCTCGCTAGCGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				0.041605791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3728	chr2	27274663	27274683	27051795	27051815	75802	hg19					enhancer	enh				GAGGGGCTCTGCGCGGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AGBL5	indirect	Non Significant	NA				-0.560516662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3729	chr2	27301355	27301375	27078487	27078507	75803	hg19					enhancer	enh				GAAGCAGATGTGGCGCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	direct	Highly Significant	NA				0.530076016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3730	chr2	27301364	27301384	27078496	27078516	75804	hg19					enhancer	enh				GTGGCGCACGATGGTTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.996676583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3731	chr2	27301483	27301503	27078615	27078635	75805	hg19					enhancer	enh				GCTGTTCGGAGGCGCGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	direct	Highly Significant	NA				0.544845527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3732	chr2	27301488	27301508	27078620	27078640	75806	hg19					enhancer	enh				GCGCCTCCGAACAGCCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	direct	Highly Significant	NA				0.292670943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3733	chr2	27301505	27301526	27078637	27078658	75807	hg19					enhancer	enh				GGTGACAGGGCTTTGCCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.058905663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3734	chr2	27301505	27301525	27078637	27078657	75808	hg19					enhancer	enh				GTGACAGGGCTTTGCCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.006464973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3735	chr2	27301530	27301551	27078662	27078683	75809	hg19					enhancer	enh				GGATCCGGTCATCAGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-4.210504337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3736	chr2	27301531	27301551	27078663	27078683	75810	hg19					enhancer	enh				GATCCGGTCATCAGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.162226732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3737	chr2	27301536	27301556	27078668	27078688	75811	hg19					enhancer	enh				GGTCATCAGGGAAAGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.76146463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3738	chr2	27301550	27301570	27078682	27078702	75812	hg19					enhancer	enh				GAGGACAGGGAGACCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	direct	Highly Significant	NA				0.370550061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3739	chr2	27301559	27301579	27078691	27078711	75813	hg19					enhancer	enh				GAGACCAGAAGAGGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.487666422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3740	chr2	27301566	27301587	27078698	27078719	75814	hg19					enhancer	enh				GAAGAGGGCCAGCTGGGACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EMILIN1	indirect	Non Significant	NA				-0.336057442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3741	chr2	27435200	27435220	27212332	27212352	75815	hg19					enhancer	enh				GCTCCGCTGCTCGCGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.388927365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3742	chr2	27435200	27435222	27212332	27212354	75816	hg19					enhancer	enh				GTGCTCCGCTGCTCGCGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				0.145368212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3743	chr2	27435208	27435230	27212340	27212362	75817	hg19					enhancer	enh				GAGCAGCGGAGCACCAAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.819113754									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3744	chr2	27435210	27435230	27212342	27212362	75818	hg19					enhancer	enh				GCAGCGGAGCACCAAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.491867378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3745	chr2	27435215	27435237	27212347	27212369	75819	hg19					enhancer	enh				GGAGCACCAAGGGAACGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	direct	Highly Significant	NA				1.335101964									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3746	chr2	27435216	27435237	27212348	27212369	75820	hg19					enhancer	enh				GAGCACCAAGGGAACGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				0.026923891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3747	chr2	27435232	27435253	27212364	27212385	75821	hg19					enhancer	enh				GAAAATGGCGCCTCACGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.243208308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3748	chr2	27435232	27435252	27212364	27212384	75822	hg19					enhancer	enh				GAAAATGGCGCCTCACGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				0.176163955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3749	chr2	27435245	27435265	27212377	27212397	75823	hg19					enhancer	enh				GTAAGACTACCCGGGTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.490932211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3750	chr2	27435248	27435270	27212380	27212402	75824	hg19					enhancer	enh				GACCCGGGTAGTCTTACGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.687927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3751	chr2	27435254	27435276	27212386	27212408	75825	hg19					enhancer	enh				GCACCAGGGTCGTAAGACTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	direct	Highly Significant	NA				1.06106011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3752	chr2	27435258	27435279	27212390	27212411	75826	hg19					enhancer	enh				GTCTTACGACCCTGGTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	direct	Highly Significant	NA				0.502069235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3753	chr2	27435278	27435299	27212410	27212431	75827	hg19					enhancer	enh				GAGGAGCAGGGCGGCAGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.040241945									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3754	chr2	27435281	27435303	27212413	27212435	75828	hg19					enhancer	enh				GCTGCCGCCCTGCTCCTCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				0.16827839									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3755	chr2	27435292	27435314	27212424	27212446	75829	hg19					enhancer	enh				GCTCCTCGCTCTGGGCGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	direct	Highly Significant	NA				0.409429897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3756	chr2	27435298	27435319	27212430	27212451	75830	hg19					enhancer	enh				GCCCTTTCCACGCCCAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.136360089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3757	chr2	27435311	27435333	27212443	27212465	75831	hg19					enhancer	enh				GAAAGGGCTCTGGCGCTACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATRAID	indirect	Non Significant	NA				-0.004617871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3758	chr2	27530640	27530662	27307772	27307794	75832	hg19					enhancer	enh				GCTCCAGCGCAGACTCGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.005975377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3759	chr2	27530646	27530667	27307778	27307799	75833	hg19					enhancer	enh				GTCCAGGACCCGAGTCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.179761181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3760	chr2	27530658	27530678	27307790	27307810	75834	hg19					enhancer	enh				GTCCTGGACCCCGGCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.05575181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3761	chr2	27530671	27530693	27307803	27307825	75835	hg19					enhancer	enh				GCCAGAGGAGCCCCGAGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	direct	Highly Significant	NA				0.8771909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3762	chr2	27530675	27530696	27307807	27307828	75836	hg19					enhancer	enh				GCAGCCAGAGGAGCCCCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.771321319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3763	chr2	27530681	27530701	27307813	27307833	75837	hg19					enhancer	enh				GGCTCCTCTGGCTGCTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.077896041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3764	chr2	27530688	27530710	27307820	27307842	75838	hg19					enhancer	enh				GCTGTGCCCTGGGAGCAGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.096947087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3765	chr2	27530694	27530716	27307826	27307848	75839	hg19					enhancer	enh				GCTCCCAGGGCACAGCTGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.236899856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3766	chr2	27530700	27530722	27307832	27307854	75840	hg19					enhancer	enh				GCTCCTGGTACAGCTGTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.64304397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3767	chr2	27530701	27530722	27307833	27307854	75841	hg19					enhancer	enh				GCTCCTGGTACAGCTGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.267502648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3768	chr2	27530708	27530729	27307840	27307861	75842	hg19					enhancer	enh				GCTGTACCAGGAGCAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.201313312									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3769	chr2	27530717	27530737	27307849	27307869	75843	hg19					enhancer	enh				GCTGGCCGCGCTGCTGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.095892494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3770	chr2	27530735	27530755	27307867	27307887	75844	hg19					enhancer	enh				GGCGGGACGCGCAGCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	direct	Highly Significant	NA				0.692046035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3771	chr2	27530740	27530762	27307872	27307894	75845	hg19					enhancer	enh				GCTGCGCGTCCCGCCTGCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.031730757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3772	chr2	27530753	27530775	27307885	27307907	75846	hg19					enhancer	enh				GCCGGCGGCACCATGAGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.637173602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3773	chr2	27530756	27530776	27307888	27307908	75847	hg19					enhancer	enh				GGCCGGCGGCACCATGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	direct	Highly Significant	NA				0.255460158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-89410	chr2	27530760	27530782	27307892	27307914	75848	hg19	N/A	N/A	N/A	Enhatls95762	enhancer	enh				GTCCAGGGCCGGCGGCACCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.02967397	UCN	chr2	27307399	27308445	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1336
enhrx-89410	chr2	27530766	27530787	27307898	27307919	75849	hg19	N/A	N/A	N/A	Enhatls95762	enhancer	enh				GCCGCCGGCCCTGGACACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.235401076	UCN	chr2	27307399	27308445	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1336
enhrx-89410	chr2	27530766	27530786	27307898	27307918	75850	hg19	N/A	N/A	N/A	Enhatls95762	enhancer	enh				GCCGCCGGCCCTGGACACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				0.160699241	UCN	chr2	27307399	27308445	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1336
enhrx-89410	chr2	27530777	27530797	27307909	27307929	75851	hg19	N/A	N/A	N/A	Enhatls95762	enhancer	enh				GCGCTGCCCCTGTGTGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UCN	indirect	Non Significant	NA				-0.06650553	UCN	chr2	27307399	27308445	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1336
enhrx-lit3774	chr2	27593290	27593310	27370423	27370443	75852	hg19					enhancer	enh				GCGAAGCGCGCAGCCCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.257128886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3775	chr2	27593433	27593454	27370566	27370587	75853	hg19					enhancer	enh				GACGCAATCGCCTGGGCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.217625747									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3776	chr2	27593441	27593461	27370574	27370594	75854	hg19					enhancer	enh				GTTCTGGGACGCAATCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.235326391									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3777	chr2	27593442	27593462	27370575	27370595	75855	hg19					enhancer	enh				GGTTCTGGGACGCAATCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	direct	Highly Significant	NA				0.966475024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3778	chr2	27593465	27593485	27370598	27370618	75856	hg19					enhancer	enh				GTCCCACCGCCTTCCCACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				0.00700442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3779	chr2	27593473	27593494	27370606	27370627	75857	hg19					enhancer	enh				GCCTTCCCACATCGGATCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				0.182782408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3780	chr2	27593473	27593493	27370606	27370626	75858	hg19					enhancer	enh				GCCTTCCCACATCGGATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				0.107617981									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3781	chr2	27593482	27593502	27370615	27370635	75859	hg19					enhancer	enh				GGGAGCCCTGCGATCCGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.071873714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3782	chr2	27593486	27593506	27370619	27370639	75860	hg19					enhancer	enh				GGATCGCAGGGCTCCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.20198209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3783	chr2	27593494	27593515	27370627	27370648	75861	hg19					enhancer	enh				GGGCTCCCAAAATGGCGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	direct	Highly Significant	NA				0.22151973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3784	chr2	27593495	27593515	27370628	27370648	75862	hg19					enhancer	enh				GGCTCCCAAAATGGCGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.003989006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3785	chr2	27593517	27593539	27370650	27370672	75863	hg19					enhancer	enh				GCTGCGGGGACTCGCTGAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.468072198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3786	chr2	27593523	27593544	27370656	27370677	75864	hg19					enhancer	enh				GGGACTCGCTGAGCAGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.5964489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3787	chr2	27593524	27593544	27370657	27370677	75865	hg19					enhancer	enh				GGACTCGCTGAGCAGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.450457015									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3788	chr2	27593545	27593565	27370678	27370698	75866	hg19					enhancer	enh				GGGAGCGTGCAGAGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.331842085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3789	chr2	27593558	27593579	27370691	27370712	75867	hg19					enhancer	enh				GCCGCTGCGGCCCTCACAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				0.060457091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3790	chr2	27593566	27593586	27370699	27370719	75868	hg19					enhancer	enh				GGCCCTCACAGTCCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				0.068590705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3791	chr2	27593571	27593591	27370704	27370724	75869	hg19					enhancer	enh				GGCCGGGCTCCGGACTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	indirect	Non Significant	NA				-0.544745158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3792	chr2	27593623	27593643	27370756	27370776	75870	hg19					enhancer	enh				GCGGGACTCGGTTTCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNX17	direct	Highly Significant	NA				0.618005533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3793	chr2	27603401	27603421	27380534	27380554	75871	hg19					enhancer	enh				GCTCCAGCCCGACGCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.160983458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3794	chr2	27603448	27603469	27380581	27380602	75872	hg19					enhancer	enh				GACAGGCGGGCCGAGATAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	direct	Highly Significant	NA				0.613728518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3795	chr2	27603500	27603520	27380633	27380653	75873	hg19					enhancer	enh				GGGCCCGCGCCGCTGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.16776175									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3796	chr2	27603544	27603565	27380677	27380698	75874	hg19					enhancer	enh				GAGCGGCCTGAGCTGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	direct	Highly Significant	NA				0.472163337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3797	chr2	27603545	27603565	27380678	27380698	75875	hg19					enhancer	enh				GAGCGGCCTGAGCTGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				0.157868163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3798	chr2	27603574	27603596	27380707	27380729	75876	hg19					enhancer	enh				GCTCCATGAATGGAAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				0.008541022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3799	chr2	27603577	27603597	27380710	27380730	75877	hg19					enhancer	enh				GGCTCCATGAATGGAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.132174633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3800	chr2	27603607	27603627	27380740	27380760	75878	hg19					enhancer	enh				GTACCAGCTGGTCTCCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.570478564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3801	chr2	27603608	27603628	27380741	27380761	75879	hg19					enhancer	enh				GGTACCAGCTGGTCTCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.236973085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3802	chr2	27603608	27603630	27380741	27380763	75880	hg19					enhancer	enh				GAGGTACCAGCTGGTCTCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.338557263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3803	chr2	27603619	27603639	27380752	27380772	75881	hg19					enhancer	enh				GCGAGTACGGAGGTACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.254420559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3804	chr2	27603629	27603649	27380762	27380782	75882	hg19					enhancer	enh				GGAAGCGGAAGCGAGTACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-1.158793165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3805	chr2	27603663	27603683	27380796	27380816	75883	hg19					enhancer	enh				GCACGGGACGCGTAGTCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.070557805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3806	chr2	27603669	27603689	27380802	27380822	75884	hg19					enhancer	enh				GACGCGTAGTCCGTGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	direct	Highly Significant	NA				0.3659511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3807	chr2	27603700	27603720	27380833	27380853	75885	hg19					enhancer	enh				GGAGCCTCAATGGCGTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				0.083775629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3808	chr2	27603716	27603737	27380849	27380870	75886	hg19					enhancer	enh				GACCGGGAAGTGATTGTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				0.070193464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3809	chr2	27603722	27603742	27380855	27380875	75887	hg19					enhancer	enh				GAAGTGATTGTGACGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF513	indirect	Non Significant	NA				-0.016332054									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3810	chr2	27651330	27651351	27428463	27428484	75888	hg19					enhancer	enh				GTCTCGGCCGGACCGGCGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.291306993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3811	chr2	27651447	27651467	27428580	27428600	75889	hg19					enhancer	enh				GGCACCGCCCATCGTTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.38002476									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3812	chr2	27651454	27651474	27428587	27428607	75890	hg19					enhancer	enh				GCGCCCGGACCAACGATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.518121242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3813	chr2	27651457	27651477	27428590	27428610	75891	hg19					enhancer	enh				GCGGCGCCCGGACCAACGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.837125637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3814	chr2	27651476	27651497	27428609	27428630	75892	hg19					enhancer	enh				GAACTGCGGGCCCCGCCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.069774912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3815	chr2	27651485	27651507	27428618	27428640	75893	hg19					enhancer	enh				GGCCCGCAGTTCGGTTGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.221705477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3816	chr2	27651486	27651507	27428619	27428640	75894	hg19					enhancer	enh				GCCCGCAGTTCGGTTGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.179984273									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3817	chr2	27651491	27651513	27428624	27428646	75895	hg19					enhancer	enh				GCTCCGCAGCGCAACCGAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-0.192620515									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3818	chr2	27651501	27651523	27428634	27428656	75896	hg19					enhancer	enh				GCGCTGCGGAGCGCAGCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-3.531053948									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3819	chr2	27651503	27651523	27428636	27428656	75897	hg19					enhancer	enh				GCTGCGGAGCGCAGCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-2.68862671									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3820	chr2	27651519	27651541	27428652	27428674	75898	hg19					enhancer	enh				GTGAGGGAGTCGCTGTGATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-4.547247053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3821	chr2	27651521	27651541	27428654	27428674	75899	hg19					enhancer	enh				GAGGGAGTCGCTGTGATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-2.414265342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3822	chr2	27651525	27651547	27428658	27428680	75900	hg19					enhancer	enh				GAGTCGCTGTGATCCGGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.004174077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3823	chr2	27651527	27651547	27428660	27428680	75901	hg19					enhancer	enh				GTCGCTGTGATCCGGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.231100407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3824	chr2	27651556	27651577	27428689	27428710	75902	hg19					enhancer	enh				GCCTGCGCTTCAGCTCCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.431055297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3825	chr2	27651561	27651581	27428694	27428714	75903	hg19					enhancer	enh				GAGCTGAAGCGCAGGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.358611118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-89437	chr2	27651588	27651609	27428721	27428742	75904	hg19	N/A	N/A	N/A	Enhatls95788	enhancer	enh				GAGTCGGGAGGTGAGCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NRBP1	indirect	Non Significant	NA				-1.764932523	NRBP1	chr2	27427789	27442259	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1363
enhrx-lit3826	chr2	27886670	27886690	27663803	27663823	75905	hg19					enhancer	enh				GTGGCGTCTGTAGGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.267911637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3827	chr2	27886714	27886735	27663847	27663868	75906	hg19					enhancer	enh				GGACAGGAACGTAAAGACCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.340083055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3828	chr2	27886715	27886735	27663848	27663868	75907	hg19					enhancer	enh				GACAGGAACGTAAAGACCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.104096652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3829	chr2	27886719	27886740	27663852	27663873	75908	hg19					enhancer	enh				GGAACGTAAAGACCGAAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-2.664406399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3830	chr2	27886720	27886740	27663853	27663873	75909	hg19					enhancer	enh				GAACGTAAAGACCGAAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.62178794									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3831	chr2	27886729	27886749	27663862	27663882	75910	hg19					enhancer	enh				GACCGAAGGGTGGGTTTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	direct	Highly Significant	NA				0.367144045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3832	chr2	27886750	27886772	27663883	27663905	75911	hg19					enhancer	enh				GGAGCGGATTTCGAAGTTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.031795199									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3833	chr2	27886751	27886772	27663884	27663905	75912	hg19					enhancer	enh				GAGCGGATTTCGAAGTTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				0.051924459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3834	chr2	27886762	27886782	27663895	27663915	75913	hg19					enhancer	enh				GAAGTTGCACCGGTTGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.719541499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3835	chr2	27886774	27886794	27663907	27663927	75914	hg19					enhancer	enh				GAATGTCAGCCATCCTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.251873406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3836	chr2	27886774	27886796	27663907	27663929	75915	hg19					enhancer	enh				GAGAATGTCAGCCATCCTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.068109522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3837	chr2	27886813	27886833	27663946	27663966	75916	hg19					enhancer	enh				GGCGTCGCAAGACCTCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.660252578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3838	chr2	27886828	27886848	27663961	27663981	75917	hg19					enhancer	enh				GCTTCTTGAAGTCCCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-1.166058874									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3839	chr2	27886835	27886857	27663968	27663990	75918	hg19					enhancer	enh				GACTTCAAGAAGCCAGCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.055052357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3840	chr2	27886850	27886870	27663983	27664003	75919	hg19					enhancer	enh				GCTGGGGACACCGGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	direct	Highly Significant	NA				0.2854417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3841	chr2	27886861	27886881	27663994	27664014	75920	hg19					enhancer	enh				GTCCCCAGCGGCGCGGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.331332047									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3842	chr2	27886866	27886886	27663999	27664019	75921	hg19					enhancer	enh				GGCCTTACTCCGCGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				0.117961787									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3843	chr2	27886887	27886907	27664020	27664040	75922	hg19					enhancer	enh				GTTTGAAGAACTGCTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				0.091657559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3844	chr2	27886935	27886957	27664068	27664090	75923	hg19					enhancer	enh				GAATTGGAGTCCTGCAACGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC4A1AP	indirect	Non Significant	NA				-0.060629729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-89541	chr2	28616595	28616617	28393728	28393750	75924	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GTCAAAGTTCCCGGGATAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.317703443	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616606	28616628	28393739	28393761	75925	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GGAACTTTGACACCTCGTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.165743699	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616607	28616628	28393740	28393761	75926	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GAACTTTGACACCTCGTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				0.082799707	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616621	28616643	28393754	28393776	75927	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GAGCCGCTGCTGCCCCGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.055164486	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616621	28616641	28393754	28393774	75928	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GCCGCTGCTGCCCCGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	direct	Highly Significant	NA				0.277660669	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616628	28616649	28393761	28393782	75929	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GCAGGAGAGCCGCTGCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.464125413	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616647	28616668	28393780	28393801	75930	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GGAGTAGGACTCGGCGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.334296074	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616647	28616667	28393780	28393800	75931	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GAGTAGGACTCGGCGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.324186517	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616653	28616673	28393786	28393806	75932	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GCCGAGTCCTACTCCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.307514545	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616656	28616676	28393789	28393809	75933	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GAGTCCTACTCCAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	direct	Highly Significant	NA				0.450599476	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616658	28616679	28393791	28393812	75934	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GTCCTACTCCAGCGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.775310277	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616677	28616697	28393810	28393830	75935	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GGCGGCCAGCAGGTAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	direct	Highly Significant	NA				0.41961883	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616677	28616697	28393810	28393830	75936	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GGCGGCCAGCAGGTAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	direct	Highly Significant	NA				0.41961883	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616681	28616703	28393814	28393836	75937	hg19	N/A	enh116199	N/A	N/A	enhancer	enh				GCCAGCAGGTAGGTGCGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.022713837	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616681	28616703	28393814	28393836	75938	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GCCAGCAGGTAGGTGCGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.022713837	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616692	28616712	28393825	28393845	75939	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GGTGCGGGCCCCGGTGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	direct	Highly Significant	NA				0.213048183	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616693	28616715	28393826	28393848	75940	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GTGCGGGCCCCGGTGCACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.19014033	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616699	28616720	28393832	28393853	75941	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GCCCCGGTGCACCTGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.276067113	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89541	chr2	28616705	28616725	28393838	28393858	75942	hg19	N/A	enh116199	N/A	Enhatls95900	enhancer	enh				GCCCGCGCCGCCAGGTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FOSL2	indirect	Non Significant	NA				-0.184514533	FOSL2	chr2	28392801	28417317	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1467
enhrx-89598	chr2	29117507	29117528	28894641	28894662	75943	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GTGCGCAGGCGCACCGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	direct	Highly Significant	NA				0.330596499	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117514	29117536	28894648	28894670	75944	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GTTCGTCCGTGCGCAGGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	direct	Highly Significant	NA				0.278269181	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117518	29117539	28894652	28894673	75945	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCCTGCGCACGGACGAACACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-0.5874335	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117522	29117543	28894656	28894677	75946	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCCACGTGTTCGTCCGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-0.101219949	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117528	29117550	28894662	28894684	75947	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GGACGAACACGTGGCTGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-1.842208213	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117529	29117550	28894663	28894684	75948	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GACGAACACGTGGCTGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-1.046554932	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117544	29117565	28894678	28894699	75949	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCAGCGGGGCCAGAGCAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-5.460652246	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117547	29117568	28894681	28894702	75950	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCGGGGCCAGAGCAGCAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-5.250174131	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117551	29117572	28894685	28894706	75951	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GGCCAGAGCAGCAATGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-1.631103363	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117552	29117572	28894686	28894706	75952	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCCAGAGCAGCAATGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-1.790404554	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117556	29117576	28894690	28894710	75953	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCCCGCCGCCATTGCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	direct	Highly Significant	NA				0.2491339	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117599	29117621	28894733	28894755	75954	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GCAAGGGACCCCAGCAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	direct	Highly Significant	NA				0.60649836	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117604	29117624	28894738	28894758	75955	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GGCGCAAGGGACCCCAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				-2.307931161	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117606	29117627	28894740	28894761	75956	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GAAGGCGCAAGGGACCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	indirect	Non Significant	NA				0.150920585	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-89598	chr2	29117641	29117662	28894775	28894796	75957	hg19	N/A	enh5380	N/A	N/A	enhancer	enh				GAGGCCAAAGCGAAGTAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR43	direct	Highly Significant	NA				0.392824465	WDR43	chr2	28894666	28948219	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	1524
enhrx-lit3845	chr2	32502873	32502894	32277804	32277825	75958	hg19					enhancer	enh				GTTGATTCCGGAAGTTTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.151104843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3846	chr2	32502902	32502923	32277833	32277854	75959	hg19					enhancer	enh				GACCCAATCAGAATCTTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.091262307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3847	chr2	32502912	32502934	32277843	32277865	75960	hg19					enhancer	enh				GAATCTTCCTCCGGGAGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.236407197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3848	chr2	32502922	32502942	32277853	32277873	75961	hg19					enhancer	enh				GCTCTCCCATTGGCTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.034472243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3849	chr2	32502970	32502992	32277901	32277923	75962	hg19					enhancer	enh				GACAGGACCATAACAGTGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.523589511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3850	chr2	32502972	32502993	32277903	32277924	75963	hg19					enhancer	enh				GTCACTGTTATGGTCCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.266444511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3851	chr2	32502978	32502999	32277909	32277930	75964	hg19					enhancer	enh				GTTATGGTCCTGTCAGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				-0.248805684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3852	chr2	32503001	32503023	32277932	32277954	75965	hg19					enhancer	enh				GACCACCCAAGCACCACGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.206227431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3853	chr2	32503023	32503044	32277954	32277975	75966	hg19					enhancer	enh				GCCACCAAGAAGACTTTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.067824049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3854	chr2	32503034	32503055	32277965	32277986	75967	hg19					enhancer	enh				GACTTTGGTGGGGTAGTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.072160164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3855	chr2	32503045	32503066	32277976	32277997	75968	hg19					enhancer	enh				GGTAGTCTCGGGGCAGCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				-0.12695693									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3856	chr2	32503046	32503066	32277977	32277997	75969	hg19					enhancer	enh				GTAGTCTCGGGGCAGCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				-0.551157011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3857	chr2	32503072	32503093	32278003	32278024	75970	hg19					enhancer	enh				GAGGCCAGAAACGGGCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.021220278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3858	chr2	32503082	32503102	32278013	32278033	75971	hg19					enhancer	enh				GCTGCGAGCGAGGCCAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.21520515									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3859	chr2	32503113	32503133	32278044	32278064	75972	hg19					enhancer	enh				GACTCGTAGGCCGCACCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				-0.211705186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3860	chr2	32503125	32503145	32278056	32278076	75973	hg19					enhancer	enh				GCACCGTAGGGCGAGCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				-1.135294297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3861	chr2	32503131	32503152	32278062	32278083	75974	hg19					enhancer	enh				GCGACCCGCACGCTCGCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	direct	Highly Significant	NA				0.296528207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3862	chr2	32503137	32503157	32278068	32278088	75975	hg19					enhancer	enh				GAGCGTGCGGGTCGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	YIPF4	indirect	Non Significant	NA				0.102296769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3863	chr2	32852988	32853008	32627921	32627941	75976	hg19					enhancer	enh				GCTTCCAAGAACTGTGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.221942631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3864	chr2	32852996	32853016	32627929	32627949	75977	hg19					enhancer	enh				GTTCTTGGAAGCGGTCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.361019821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3865	chr2	32853065	32853085	32627998	32628018	75978	hg19					enhancer	enh				GGTTATGCCCCACCCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	direct	Highly Significant	NA				0.24563912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3866	chr2	32853072	32853092	32628005	32628025	75979	hg19					enhancer	enh				GTGGGGCATAACCACCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.11399092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3867	chr2	32853100	32853120	32628033	32628053	75980	hg19					enhancer	enh				GAAGAACCCGAGCTTGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-1.111457796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3868	chr2	32853107	32853127	32628040	32628060	75981	hg19					enhancer	enh				GCTCGGGTTCTTCTCCTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.841265982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3869	chr2	32853171	32853192	32628104	32628125	75982	hg19					enhancer	enh				GGCGGCCATAACAGCAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-2.106050266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3870	chr2	32853171	32853191	32628104	32628124	75983	hg19					enhancer	enh				GCGGCCATAACAGCAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-1.599348737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3871	chr2	32853172	32853192	32628105	32628125	75984	hg19					enhancer	enh				GGCGGCCATAACAGCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.963907182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3872	chr2	32853190	32853211	32628123	32628144	75985	hg19					enhancer	enh				GCGGATACTACCTCAAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-1.141544931									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3873	chr2	32853193	32853213	32628126	32628146	75986	hg19					enhancer	enh				GTGCGGATACTACCTCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-2.623859666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3874	chr2	32853209	32853231	32628142	32628164	75987	hg19					enhancer	enh				GCACATGGAATTCTAGGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				0.1113931									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3875	chr2	32853257	32853279	32628190	32628212	75988	hg19					enhancer	enh				GTCCAAAGGCGCTGAAATCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-0.874647308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3876	chr2	32853273	32853293	32628206	32628226	75989	hg19					enhancer	enh				GTGAAAACAGGAGAGTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-5.113306036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3877	chr2	32853301	32853323	32628234	32628256	75990	hg19					enhancer	enh				GTTGACTCCCGTGTGGCCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-1.542755604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3878	chr2	32853311	32853331	32628244	32628264	75991	hg19					enhancer	enh				GGCTCCCACGAGGGCCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-2.330926676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3879	chr2	32853320	32853340	32628253	32628273	75992	hg19					enhancer	enh				GCCAAAACAGGCTCCCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-2.469915352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3880	chr2	32853332	32853352	32628265	32628285	75993	hg19					enhancer	enh				GACACCGCTGCAGCCAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-1.0227556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3881	chr2	32853349	32853369	32628282	32628302	75994	hg19					enhancer	enh				GTCTGGGGTGATGTGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTC27	indirect	Non Significant	NA				-3.012460981									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3882	chr2	36825132	36825152	36597989	36598009	75995	hg19					enhancer	enh				GGCCGGGGCCGGGAAACCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				0.048342985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3883	chr2	36825188	36825209	36598045	36598066	75996	hg19					enhancer	enh				GTAACGCGAGCCCCGAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	direct	Highly Significant	NA				0.448695998									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3884	chr2	36825189	36825209	36598046	36598066	75997	hg19					enhancer	enh				GTAACGCGAGCCCCGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.030485309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3885	chr2	36825197	36825217	36598054	36598074	75998	hg19					enhancer	enh				GGCTCGCGTTACAGTTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	direct	Highly Significant	NA				0.235541738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3886	chr2	36825202	36825223	36598059	36598080	75999	hg19					enhancer	enh				GCGTTACAGTTCTCCTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.177546553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3887	chr2	36825210	36825232	36598067	36598089	76000	hg19					enhancer	enh				GTTCTCCTGGTCCAGGAGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				0.132094436									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3888	chr2	36825218	36825238	36598075	36598095	76001	hg19					enhancer	enh				GGCCCGGAGCCTCCTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				0.148285033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3889	chr2	36825224	36825244	36598081	36598101	76002	hg19					enhancer	enh				GGAGGCTCCGGGCCGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.221606034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3890	chr2	36825239	36825261	36598096	36598118	76003	hg19					enhancer	enh				GATTTCTATGAGTTCCAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.019041642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3891	chr2	36825281	36825302	36598138	36598159	76004	hg19					enhancer	enh				GACTGCTCCGGGCGGCGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.348518513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3892	chr2	36825284	36825304	36598141	36598161	76005	hg19					enhancer	enh				GCGACTGCTCCGGGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	direct	Highly Significant	NA				0.390018368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3893	chr2	36825294	36825314	36598151	36598171	76006	hg19					enhancer	enh				GGCGGGGCGCGCGACTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-0.401767829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3894	chr2	36825367	36825387	36598224	36598244	76007	hg19					enhancer	enh				GTCAGCACGGTAGCGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	direct	Highly Significant	NA				0.214075441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3895	chr2	36825373	36825393	36598230	36598250	76008	hg19					enhancer	enh				GGATCTGTCAGCACGGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FEZ2	indirect	Non Significant	NA				-1.129480342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3896	chr2	37423486	37423507	37196343	37196364	76009	hg19					enhancer	enh				GTTCGCAATAACACATGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				0.041948252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3897	chr2	37423531	37423551	37196388	37196408	76010	hg19					enhancer	enh				GGGCAGTCAGGTTCGGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.224170662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3898	chr2	37423587	37423607	37196444	37196464	76011	hg19					enhancer	enh				GGGCGGAGCCGACAACGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.579602267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3899	chr2	37423591	37423611	37196448	37196468	76012	hg19					enhancer	enh				GGAGCCGACAACGGAAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.29635837									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3900	chr2	37423624	37423645	37196481	37196502	76013	hg19					enhancer	enh				GGACTGCGCATGCGCAACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.778794784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3901	chr2	37423624	37423646	37196481	37196503	76014	hg19					enhancer	enh				GGGACTGCGCATGCGCAACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.236181858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3902	chr2	37423624	37423644	37196481	37196501	76015	hg19					enhancer	enh				GACTGCGCATGCGCAACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.229734491									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-90103	chr2	37423648	37423670	37196505	37196527	76016	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTCTTACCTGAGGTGCGTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.125056249	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423648	37423670	37196505	37196527	76017	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTCTTACCTGAGGTGCGTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.125056249	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423650	37423672	37196507	37196529	76018	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAACGCACCTCAGGTAAGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				0.060170622	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423650	37423672	37196507	37196529	76019	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAACGCACCTCAGGTAAGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				0.060170622	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423667	37423689	37196524	37196546	76020	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GACTCTGGCGAGTGGCTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.309832436	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423667	37423689	37196524	37196546	76021	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GACTCTGGCGAGTGGCTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.309832436	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423673	37423693	37196530	37196550	76022	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GGCGAGTGGCTTCCCATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.587012276	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423673	37423693	37196530	37196550	76023	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GGCGAGTGGCTTCCCATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.587012276	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423676	37423697	37196533	37196554	76024	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGCTTCCCATGGGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.060534713	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423676	37423697	37196533	37196554	76025	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGCTTCCCATGGGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.060534713	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423689	37423711	37196546	37196568	76026	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GACCCCGAAATCCGACCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.219505137	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423689	37423711	37196546	37196568	76027	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GACCCCGAAATCCGACCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.219505137	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423707	37423728	37196564	37196585	76028	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GGTCCCTAGTGCGACGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.335819354	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423707	37423728	37196564	37196585	76029	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GGTCCCTAGTGCGACGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.335819354	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423708	37423728	37196565	37196585	76030	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTCCCTAGTGCGACGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.286040628	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423708	37423728	37196565	37196585	76031	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTCCCTAGTGCGACGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.286040628	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423713	37423733	37196570	37196590	76032	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GCCCCACTCTCGTCGCACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				0.043863761	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423713	37423733	37196570	37196590	76033	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GCCCCACTCTCGTCGCACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				0.043863761	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423724	37423744	37196581	37196601	76034	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGGGCGGTCTTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.297800214	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423724	37423744	37196581	37196601	76035	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGGGCGGTCTTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	indirect	Non Significant	NA				-0.297800214	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423724	37423745	37196581	37196602	76036	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGGGCGGTCTTCTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.444777626	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423724	37423745	37196581	37196602	76037	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GAGTGGGGCGGTCTTCTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.444777626	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423787	37423807	37196644	37196664	76038	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTGTCACTGCCTTAATTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.202225037	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423787	37423807	37196644	37196664	76039	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GTGTCACTGCCTTAATTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.202225037	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423812	37423832	37196669	37196689	76040	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GCGAGTGTTTCCGGGTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.241549433	SULT6B1	chr2	37167819	37196598	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-90103	chr2	37423812	37423832	37196669	37196689	76041	hg19	N/A	N/A	N/A	Enhatls96519	enhancer	enh				GCGAGTGTTTCCGGGTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CEBPZ-AS1	direct	Highly Significant	NA				0.241549433	CEBPZOS	chr2	37196487	37213725	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2029
enhrx-lit3903	chr2	38829890	38829910	38602748	38602768	76042	hg19					enhancer	enh				GCGCAGTCCCCGCGGACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.067072712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3904	chr2	38829926	38829948	38602784	38602806	76043	hg19					enhancer	enh				GCTGAGAAGCGCGGACGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-1.234063037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3905	chr2	38829953	38829973	38602811	38602831	76044	hg19					enhancer	enh				GGCGCCCCGGGAGGAAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.100249689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3906	chr2	38829960	38829982	38602818	38602840	76045	hg19					enhancer	enh				GCCGCTCCAGAGCTTCCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.461741229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-90188	chr2	38829984	38830004	38602842	38602862	76046	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGCTCGGTAATTGAGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.020646397	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38829989	38830011	38602847	38602869	76047	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GAATGTTGGCTCGGTAATTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.704996991	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830000	38830020	38602858	38602878	76048	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGAGAGGCTGAATGTTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.368933262	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830000	38830021	38602858	38602879	76049	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGGAGAGGCTGAATGTTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.038428887	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830050	38830070	38602908	38602928	76050	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGAGGAGCGAATCTAAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.385183568	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830051	38830071	38602909	38602929	76051	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GAGGAGCGAATCTAAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.383655924	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830083	38830103	38602941	38602961	76052	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGAGGGAAGACCGGAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.543548473	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830083	38830105	38602941	38602963	76053	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GAGGAGGGAAGACCGGAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.114329369	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830146	38830166	38603004	38603024	76054	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GCGCGACGGCCGCGAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.448595924	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830151	38830172	38603009	38603030	76055	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GATCCTGCGCGACGGCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				0.104897969	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830213	38830233	38603071	38603091	76056	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GGTTCTGCTCCCTATTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	direct	Highly Significant	NA				0.2031123	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830230	38830250	38603088	38603108	76057	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GCAGGGGCGGGAAAGTCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.660553226	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-90188	chr2	38830240	38830262	38603098	38603120	76058	hg19	N/A	N/A	N/A	Enhatls96617	enhancer	enh				GAAAGTCGACCGGGCTTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HNRNPLL	indirect	Non Significant	NA				-0.009665112	HNRNPLL	chr2	38561968	38603036	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2114
enhrx-lit3907	chr2	39102896	39102916	38875754	38875774	76059	hg19					enhancer	enh				GCATCACTTGTCCGCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.376240715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3908	chr2	39102909	39102929	38875767	38875787	76060	hg19					enhancer	enh				GCAGAAGTGGAAGACGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-0.891825533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3909	chr2	39102921	39102942	38875779	38875800	76061	hg19					enhancer	enh				GACGTACCTGGCTCGCAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.281583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3910	chr2	39102930	39102950	38875788	38875808	76062	hg19					enhancer	enh				GGGACCCAACTCTGCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.495918703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3911	chr2	39102945	39102965	38875803	38875823	76063	hg19					enhancer	enh				GTCCCGAGCCGGCTGTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-0.283774802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3912	chr2	39102950	39102971	38875808	38875829	76064	hg19					enhancer	enh				GCACCTCCCGACAGCCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-0.341053947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3913	chr2	39102951	39102971	38875809	38875829	76065	hg19					enhancer	enh				GCACCTCCCGACAGCCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.40807243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3914	chr2	39102956	39102978	38875814	38875836	76066	hg19					enhancer	enh				GCTGTCGGGAGGTGCTGCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-1.164809721									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3915	chr2	39102956	39102976	38875814	38875834	76067	hg19					enhancer	enh				GGGCAGCACCTCCCGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.47161019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3916	chr2	39102964	39102985	38875822	38875843	76068	hg19					enhancer	enh				GAGGTGCTGCCCAAGGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.334411104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3917	chr2	39102980	39103001	38875838	38875859	76069	hg19					enhancer	enh				GTCAGAGGTCCAAACTGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				0.173712062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3918	chr2	39103002	39103024	38875860	38875882	76070	hg19					enhancer	enh				GGCCACCCTCACGATTCTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				0.136255484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3919	chr2	39103003	39103024	38875861	38875882	76071	hg19					enhancer	enh				GCCACCCTCACGATTCTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.705732281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3920	chr2	39103010	39103030	38875868	38875888	76072	hg19					enhancer	enh				GCTCCAAGTGAGAATCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.264616888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3921	chr2	39103011	39103033	38875869	38875892	76073	hg19					enhancer	enh				GCTGCTCCAAGTGAGAATCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.371105073									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3922	chr2	39103031	39103053	38875889	38875912	76074	hg19					enhancer	enh				GCCTGCGGTGGCCCAGCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.206641432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3923	chr2	39103035	39103057	38875894	38875916	76075	hg19					enhancer	enh				GCCGCTGCAGCTGGGCCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.220472343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3924	chr2	39103045	39103065	38875904	38875924	76076	hg19					enhancer	enh				GGGACTGTGCCGCTGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				0.165699576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3925	chr2	39103046	39103068	38875905	38875927	76077	hg19					enhancer	enh				GCCGGGACTGTGCCGCTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.233420989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3926	chr2	39103065	39103087	38875924	38875946	76078	hg19					enhancer	enh				GCTGAGCCAATCAGAAGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.216147896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3927	chr2	39103066	39103087	38875925	38875946	76079	hg19					enhancer	enh				GCTGAGCCAATCAGAAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.346249082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3928	chr2	39103072	39103093	38875931	38875952	76080	hg19					enhancer	enh				GCTGTAGCTGAGCCAATCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				-0.207866543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3929	chr2	39103072	39103094	38875931	38875953	76081	hg19					enhancer	enh				GGCTGTAGCTGAGCCAATCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.294916035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3930	chr2	39103098	39103119	38875957	38875978	76082	hg19					enhancer	enh				GCGTATTCGCTTCCGGGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				0.108787963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3931	chr2	39103106	39103126	38875965	38875985	76083	hg19					enhancer	enh				GCTTCCGGGTGAGAGGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-1.152794935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3932	chr2	39103113	39103134	38875972	38875993	76084	hg19					enhancer	enh				GGCGACCGGGCACCTCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				0.040275619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3933	chr2	39103113	39103133	38875972	38875992	76085	hg19					enhancer	enh				GCGACCGGGCACCTCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	direct	Highly Significant	NA				0.361996163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3934	chr2	39103127	39103148	38875986	38876007	76086	hg19					enhancer	enh				GACTTGGTTGCTGGGGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				0.163814492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3935	chr2	39103128	39103148	38875987	38876007	76087	hg19					enhancer	enh				GACTTGGTTGCTGGGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				0.006638613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3936	chr2	39103131	39103153	38875990	38876012	76088	hg19					enhancer	enh				GCCCCAGCAACCAAGTCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				-0.174241511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3937	chr2	39103144	39103164	38876003	38876023	76089	hg19					enhancer	enh				GGACAGCTCCAGGTGCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				-0.034156835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3938	chr2	39103160	39103182	38876019	38876041	76090	hg19					enhancer	enh				GTCCTAGCGCCTAGTTCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				-0.226347191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3939	chr2	39103165	39103187	38876024	38876046	76091	hg19					enhancer	enh				GGCCGGGAGAGAACTAGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-0.105171799									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3940	chr2	39103165	39103186	38876024	38876045	76092	hg19					enhancer	enh				GCCGGGAGAGAACTAGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.585501832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3941	chr2	39103172	39103194	38876031	38876053	76093	hg19					enhancer	enh				GCTCTGCGGCCGGGAGAGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	direct	Highly Significant	NA				0.218494409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3942	chr2	39103173	39103194	38876032	38876053	76094	hg19					enhancer	enh				GTTCTCTCCCGGCCGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DHX57	indirect	Non Significant	NA				-0.27916691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3943	chr2	39103183	39103205	38876042	38876064	76095	hg19					enhancer	enh				GGCCGCAGAGCTGGCCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				-0.079078967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3944	chr2	39103184	39103205	38876043	38876064	76096	hg19					enhancer	enh				GCCGCAGAGCTGGCCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MORN2	indirect	Non Significant	NA				0.055455302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3945	chr2	39664228	39664250	39437087	39437109	76097	hg19					enhancer	enh				GCCGGGTGATTGTGACCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.919646056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3946	chr2	39664276	39664297	39437135	39437156	76098	hg19					enhancer	enh				GCCGCTCCCCTCACGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	indirect	Non Significant	NA				-0.483728963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3947	chr2	39664285	39664305	39437144	39437164	76099	hg19					enhancer	enh				GTCGTCCGCAGCGGCGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				1.000830679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3948	chr2	39664290	39664311	39437149	39437170	76100	hg19					enhancer	enh				GCCGCTGCGGACGACGACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	indirect	Non Significant	NA				-0.447461887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3949	chr2	39664340	39664361	39437199	39437220	76101	hg19					enhancer	enh				GACCAGGTTCGGCGCGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	indirect	Non Significant	NA				0.132853606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3950	chr2	39664341	39664361	39437200	39437220	76102	hg19					enhancer	enh				GACCAGGTTCGGCGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.613599469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3951	chr2	39664347	39664367	39437206	39437226	76103	hg19					enhancer	enh				GGGTGTGACCAGGTTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.975888766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3952	chr2	39664348	39664370	39437207	39437229	76104	hg19					enhancer	enh				GCCGAACCTGGTCACACCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.774354848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3953	chr2	39664379	39664401	39437238	39437260	76105	hg19					enhancer	enh				GAACCCTCGCAGCCCCTCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.590271665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3954	chr2	39664379	39664400	39437238	39437259	76106	hg19					enhancer	enh				GAACCCTCGCAGCCCCTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	indirect	Non Significant	NA				0.156949018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3955	chr2	39664395	39664417	39437254	39437276	76107	hg19					enhancer	enh				GTTGGAGTTTCACCCCGAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.531771713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3956	chr2	39664396	39664417	39437255	39437276	76108	hg19					enhancer	enh				GTTGGAGTTTCACCCCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MAP4K3	direct	Highly Significant	NA				0.937966877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3957	chr2	42274967	42274987	42047827	42047847	76109	hg19					enhancer	enh				GACAGCGGGACCTCCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	direct	Highly Significant	NA				0.296223432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3958	chr2	42274975	42274995	42047835	42047855	76110	hg19					enhancer	enh				GGTCCCGCTGTCAGTCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				0.198578869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3959	chr2	42274981	42275003	42047841	42047863	76111	hg19					enhancer	enh				GCCTTCCCCGCTGACTGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	direct	Highly Significant	NA				0.675729166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3960	chr2	42275116	42275138	42047976	42047998	76112	hg19					enhancer	enh				GGGCGGCTCTGGGCCTTATAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.069139525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3961	chr2	42275121	42275143	42047981	42048003	76113	hg19					enhancer	enh				GCTCTGGGCCTTATAAGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.209444719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3962	chr2	42275121	42275141	42047981	42048001	76114	hg19					enhancer	enh				GCTCTGGGCCTTATAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				0.183064132									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3963	chr2	42275172	42275193	42048032	42048053	76115	hg19					enhancer	enh				GGCCGATGTGTCGCCCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.076728967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3964	chr2	42275172	42275192	42048032	42048052	76116	hg19					enhancer	enh				GGCCGATGTGTCGCCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				0.147104201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3965	chr2	42275173	42275193	42048033	42048053	76117	hg19					enhancer	enh				GCCGATGTGTCGCCCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.362911776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3966	chr2	42275177	42275198	42048037	42048058	76118	hg19					enhancer	enh				GGCCCCTCGCGGGCGACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.087771551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3967	chr2	42275177	42275197	42048037	42048057	76119	hg19					enhancer	enh				GCCCCTCGCGGGCGACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.01246332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3968	chr2	42275179	42275199	42048039	42048059	76120	hg19					enhancer	enh				GTGTCGCCCGCGAGGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	direct	Highly Significant	NA				0.50607469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3969	chr2	42275214	42275236	42048074	42048096	76121	hg19					enhancer	enh				GCCCAGCCCGCGCGCATGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				0.06436346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3970	chr2	42275216	42275237	42048076	42048097	76122	hg19					enhancer	enh				GCCATGCGCGCGGGCTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	direct	Highly Significant	NA				0.208748776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3971	chr2	42275245	42275265	42048105	42048125	76123	hg19					enhancer	enh				GGCTCCGCTCTGCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				0.13723182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3972	chr2	42275249	42275269	42048109	42048129	76124	hg19					enhancer	enh				GGCGCAGAGCGGAGCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.485439286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3973	chr2	42275265	42275287	42048125	42048147	76125	hg19					enhancer	enh				GCCTCGGAGCCTGAGCCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PKDCC	indirect	Non Significant	NA				-0.2408646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3974	chr2	43864355	43864377	43637216	43637238	76126	hg19					enhancer	enh				GACTGGCAGCCGGTGTAGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.050377599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3975	chr2	43864367	43864389	43637228	43637250	76127	hg19					enhancer	enh				GCCTCCTCCAGGGACTGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.039146151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3976	chr2	43864374	43864395	43637235	43637256	76128	hg19					enhancer	enh				GGCACCGCCTCCTCCAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.392011722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3977	chr2	43864374	43864394	43637235	43637255	76129	hg19					enhancer	enh				GCACCGCCTCCTCCAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				0.096593108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3978	chr2	43864379	43864400	43637240	43637261	76130	hg19					enhancer	enh				GGAAGGGCACCGCCTCCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.143196701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3979	chr2	43864379	43864399	43637240	43637260	76131	hg19					enhancer	enh				GAAGGGCACCGCCTCCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.917267952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3980	chr2	43864406	43864427	43637267	43637288	76132	hg19					enhancer	enh				GCCTCAAGCCGAGCTCGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	direct	Highly Significant	NA				0.499851074									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3981	chr2	43864407	43864427	43637268	43637288	76133	hg19					enhancer	enh				GCCTCAAGCCGAGCTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.318393061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3982	chr2	43864412	43864433	43637273	43637294	76134	hg19					enhancer	enh				GCGCCCGCCTCAAGCCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				0.042709319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3983	chr2	43864413	43864433	43637274	43637294	76135	hg19					enhancer	enh				GCTCGGCTTGAGGCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.062184151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3984	chr2	43864435	43864457	43637296	43637318	76136	hg19					enhancer	enh				GCTGAGAGTCCGGGGATCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-1.548363595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3985	chr2	43864435	43864456	43637296	43637317	76137	hg19					enhancer	enh				GCTGAGAGTCCGGGGATCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.825136637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3986	chr2	43864457	43864479	43637318	43637340	76138	hg19					enhancer	enh				GGGCCAGTCGCGGCCGGGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	direct	Highly Significant	NA				0.53354459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3987	chr2	43864468	43864488	43637329	43637349	76139	hg19					enhancer	enh				GGCCGGGACATCGGGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	direct	Highly Significant	NA				0.254800122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3988	chr2	43864473	43864493	43637334	43637354	76140	hg19					enhancer	enh				GGCCGCAGCGCCCGATGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.022641851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3989	chr2	43864496	43864516	43637357	43637377	76141	hg19					enhancer	enh				GACCCGCTGCTGAGATAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLEKHH2	indirect	Non Significant	NA				-0.289635028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3990	chr2	44001138	44001158	43773999	43774019	76142	hg19					enhancer	enh				GTCGCGGCCGCGGTTGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.196131815									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3991	chr2	44001147	44001168	43774008	43774029	76143	hg19					enhancer	enh				GCGGCCGCGACGTCGCTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.196858405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3992	chr2	44001154	44001175	43774015	43774036	76144	hg19					enhancer	enh				GTTGCCATGGGAGCGACGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.089761734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3993	chr2	44001158	44001180	43774019	43774041	76145	hg19					enhancer	enh				GTCGCTCCCATGGCAACCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.294840457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3994	chr2	44001167	44001189	43774028	43774050	76146	hg19					enhancer	enh				GTGAGGCCTTCTGGGTTGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.196936457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3995	chr2	44001167	44001187	43774028	43774048	76147	hg19					enhancer	enh				GAGGCCTTCTGGGTTGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.138689209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3996	chr2	44001194	44001214	43774055	43774075	76148	hg19					enhancer	enh				GGCGAGCTCCGCAAGGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.043666219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3997	chr2	44001194	44001216	43774055	43774077	76149	hg19					enhancer	enh				GCGGCGAGCTCCGCAAGGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.615283711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3998	chr2	44001201	44001223	43774062	43774084	76150	hg19					enhancer	enh				GAATCAGGCGGCGAGCTCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.071571366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit3999	chr2	44001207	44001228	43774068	43774089	76151	hg19					enhancer	enh				GCTCGCCGCCTGATTCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.047280579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4000	chr2	44001218	44001238	43774079	43774099	76152	hg19					enhancer	enh				GTAGTGACCAGCCTAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				0.601254462									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4001	chr2	44001218	44001240	43774079	43774101	76153	hg19					enhancer	enh				GAGTAGTGACCAGCCTAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				0.519327014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4002	chr2	44001242	44001264	43774103	43774125	76154	hg19					enhancer	enh				GCTGCCGCAAACGTCACAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				0.624453561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4003	chr2	44001243	44001265	43774104	43774126	76155	hg19					enhancer	enh				GCCTGTGACGTTTGCGGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				1.116894152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4004	chr2	44001247	44001269	43774108	43774130	76156	hg19					enhancer	enh				GCCTGGCTGCCGCAAACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.003355641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4005	chr2	44001262	44001283	43774123	43774144	76157	hg19					enhancer	enh				GCCAGGCCGTCGACGATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				0.138376291									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-90457	chr2	44001271	44001292	43774132	43774153	76158	hg19	N/A	N/A	N/A	Enhatls96910	enhancer	enh				GGAATACCTGGGCATCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.773457502	DYNC2LI1	chr2	43774038	43810010	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2383
enhrx-90457	chr2	44001271	44001291	43774132	43774152	76159	hg19	N/A	N/A	N/A	Enhatls96910	enhancer	enh				GAATACCTGGGCATCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	indirect	Non Significant	NA				-0.301920893	DYNC2LI1	chr2	43774038	43810010	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2383
enhrx-90457	chr2	44001283	44001303	43774144	43774164	76160	hg19	N/A	N/A	N/A	Enhatls96910	enhancer	enh				GCCGGGTTCAGGGAATACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				0.232858009	DYNC2LI1	chr2	43774038	43810010	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2383
enhrx-90457	chr2	44001301	44001321	43774162	43774182	76161	hg19	N/A	N/A	N/A	Enhatls96910	enhancer	enh				GTAGCCTTTCCCACGCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DYNC2LI1	direct	Highly Significant	NA				0.775816075	DYNC2LI1	chr2	43774038	43810010	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2383
enhrx-lit4006	chr2	46524354	46524375	46297215	46297236	76162	hg19					enhancer	enh				GCTGCGGCCGCGCGTCCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.091392731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4007	chr2	46524364	46524385	46297225	46297246	76163	hg19					enhancer	enh				GTCCCGGCCAATGGGGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.318981708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4008	chr2	46524372	46524394	46297233	46297255	76164	hg19					enhancer	enh				GCTCACTGCGTCCCGGCCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.200565516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4009	chr2	46524531	46524551	46297392	46297412	76165	hg19					enhancer	enh				GAGTGTAAAGCTCCCGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				0.053337126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4010	chr2	46524534	46524556	46297395	46297417	76166	hg19					enhancer	enh				GCGGGAGCTTTACACTCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.223734998									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4011	chr2	46524535	46524557	46297396	46297418	76167	hg19					enhancer	enh				GCTCGCGAGTGTAAAGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				0.029219421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4012	chr2	46524536	46524556	46297397	46297417	76168	hg19					enhancer	enh				GGGAGCTTTACACTCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.308997712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4013	chr2	46524553	46524574	46297414	46297435	76169	hg19					enhancer	enh				GAGCGGACCGCCACACGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				0.03508798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4014	chr2	46524563	46524584	46297424	46297445	76170	hg19					enhancer	enh				GCGGGCACCGGACCCGTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.274899992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4015	chr2	46524566	46524587	46297427	46297448	76171	hg19					enhancer	enh				GCAGCGGGCACCGGACCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.638872896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4016	chr2	46524576	46524596	46297437	46297457	76172	hg19					enhancer	enh				GGCGGAAGCGCAGCGGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.000302403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4017	chr2	46524587	46524608	46297448	46297469	76173	hg19					enhancer	enh				GCTTCCGCCCCAGCGCTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.096523034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4018	chr2	46524594	46524615	46297455	46297476	76174	hg19					enhancer	enh				GCCGCCTCAGGAGCGCTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.973522168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4019	chr2	46524598	46524620	46297459	46297481	76175	hg19					enhancer	enh				GTACGGCCGCCTCAGGAGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				0.083697122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4020	chr2	46524599	46524620	46297460	46297481	76176	hg19					enhancer	enh				GTACGGCCGCCTCAGGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				0.135880577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4021	chr2	46524607	46524627	46297468	46297488	76177	hg19					enhancer	enh				GAGGATTGTACGGCCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	indirect	Non Significant	NA				-0.65178184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4022	chr2	46524676	46524697	46297537	46297558	76178	hg19					enhancer	enh				GCTCGAATGCTGGGAGTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPAS1	direct	Highly Significant	NA				0.280746982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4023	chr2	46656167	46656188	46429028	46429049	76179	hg19					enhancer	enh				GTCCTCTGGAGATCCAGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				0.023519815									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4024	chr2	46656207	46656228	46429068	46429089	76180	hg19					enhancer	enh				GCCACTCAAAGGCTCTGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.452697419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4025	chr2	46656236	46656256	46429097	46429117	76181	hg19					enhancer	enh				GCCATGCTTCCGGCCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				0.154013066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4026	chr2	46656242	46656262	46429103	46429123	76182	hg19					enhancer	enh				GCCGCCGCCATGCTTCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.159787703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4027	chr2	46656273	46656294	46429134	46429155	76183	hg19					enhancer	enh				GACCCGCCCTGCCACACCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.371210863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4028	chr2	46656311	46656333	46429172	46429194	76184	hg19					enhancer	enh				GCCACAGAGCAACGTAAAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.279051262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4029	chr2	46656362	46656384	46429223	46429245	76185	hg19					enhancer	enh				GAAGGAGACCTACTGAGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.321930345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4030	chr2	46656373	46656393	46429234	46429254	76186	hg19					enhancer	enh				GGTTGTCCTCAGGACTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.115820128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4031	chr2	46656376	46656398	46429237	46429259	76187	hg19					enhancer	enh				GAGTCCTGAGGACAACCAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.406437628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4032	chr2	46656378	46656398	46429239	46429259	76188	hg19					enhancer	enh				GTCCTGAGGACAACCAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.353393873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-90599	chr2	46656409	46656431	46429270	46429292	76189	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GCACAGAAGGTGAGCAAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.262875645	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656414	46656434	46429275	46429295	76190	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GAAGGTGAGCAAAGTCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.116612139	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656436	46656457	46429297	46429318	76191	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GAGGGTGAGCAGAAGGATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-2.102693245	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656444	46656466	46429305	46429327	76192	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GCAGAAGGATCAGTGGCCATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.317405375	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656447	46656467	46429308	46429328	76193	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GAAGGATCAGTGGCCATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.507524405	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656451	46656471	46429312	46429332	76194	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GATCAGTGGCCATCGCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				-0.322746861	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656463	46656483	46429324	46429344	76195	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GAACTAACACCAACCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	direct	Highly Significant	NA				0.493742818	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-90599	chr2	46656528	46656549	46429389	46429410	76196	hg19	N/A	N/A	N/A	Enhatls97065	enhancer	enh				GCATGTCCAGCGGGCCAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM247	indirect	Non Significant	NA				0.156821178	EPAS1	chr2	46296607	46386697	42585				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	2525
enhrx-lit4033	chr2	46769524	46769544	46542385	46542405	76197	hg19					enhancer	enh				GCGTCCAAAGGCCCCGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-1.495781324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4034	chr2	46769536	46769557	46542397	46542418	76198	hg19					enhancer	enh				GCAGCGCCCGGAAGCGTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-0.433091241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4035	chr2	46769550	46769570	46542411	46542431	76199	hg19					enhancer	enh				GCGCTGCGGGCACTTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-0.010721955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4036	chr2	46769559	46769579	46542420	46542440	76200	hg19					enhancer	enh				GCACTTGCGCGAGGAGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-0.309297667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4037	chr2	46769567	46769588	46542428	46542449	76201	hg19					enhancer	enh				GCGAGGAGCCCTCGGCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	direct	Highly Significant	NA				0.435776879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4038	chr2	46769578	46769598	46542439	46542459	76202	hg19					enhancer	enh				GGAGTCGCCTGGGGAGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	direct	Highly Significant	NA				0.415626234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4039	chr2	46769592	46769612	46542453	46542473	76203	hg19					enhancer	enh				GACTCCCCTCCTCCCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-1.255546048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4040	chr2	46769608	46769628	46542469	46542489	76204	hg19					enhancer	enh				GAGGAGCCGAGGACCGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	direct	Highly Significant	NA				0.23701135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4041	chr2	46769648	46769668	46542509	46542529	76205	hg19					enhancer	enh				GCGCGGCCCTCGCAGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-0.349588825									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4042	chr2	46769653	46769675	46542514	46542536	76206	hg19					enhancer	enh				GCCCTCGCAGGGAGTGGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				0.060321695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4043	chr2	46769653	46769674	46542514	46542535	76207	hg19					enhancer	enh				GCCCTCGCAGGGAGTGGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATP6V1E2	indirect	Non Significant	NA				-0.188171502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4044	chr2	46844158	46844178	46617019	46617039	76208	hg19					enhancer	enh				GGGCCGCCCGTCGTACCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.432162266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4045	chr2	46844219	46844240	46617080	46617101	76209	hg19					enhancer	enh				GCCTAACAGCCAGTCGCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.408210007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4046	chr2	46844267	46844289	46617128	46617150	76210	hg19					enhancer	enh				GCTTTCCAGGTTTGGGGTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.722978532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4047	chr2	46844287	46844309	46617148	46617170	76211	hg19					enhancer	enh				GCGGGAGTATGGGCTTAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				-0.874126326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4048	chr2	46844293	46844315	46617154	46617176	76212	hg19					enhancer	enh				GTATGGGCTTAGAAGCCGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				-0.566061717									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4049	chr2	46844310	46844330	46617171	46617191	76213	hg19					enhancer	enh				GGAAGTGGGTTGACGTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.371469649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4050	chr2	46844314	46844335	46617175	46617196	76214	hg19					enhancer	enh				GTGGGTTGACGTAGCCCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				-0.482982008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4051	chr2	46844314	46844334	46617175	46617195	76215	hg19					enhancer	enh				GTGGGTTGACGTAGCCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				-0.106706239									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4052	chr2	46844381	46844401	46617242	46617262	76216	hg19					enhancer	enh				GCTGCTGCTGTTGCGGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				-0.077933876									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4053	chr2	46844390	46844412	46617251	46617273	76217	hg19					enhancer	enh				GTTGCGGCTAGGGGAACCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				1.812648291									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4054	chr2	46844393	46844414	46617254	46617275	76218	hg19					enhancer	enh				GCGGCTAGGGGAACCGTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.440563866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4055	chr2	46844402	46844422	46617263	46617283	76219	hg19					enhancer	enh				GGAACCGTCGTGGGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				0.046093761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4056	chr2	46844409	46844430	46617270	46617291	76220	hg19					enhancer	enh				GCACACCATCCTTCCCCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				0.014461779									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4057	chr2	46844439	46844460	46617300	46617321	76221	hg19					enhancer	enh				GAGTTAAGGGGCCGCTTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.230520769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4058	chr2	46844441	46844463	46617302	46617324	76222	hg19					enhancer	enh				GTTAAGGGGCCGCTTCTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				0.011019697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4059	chr2	46844453	46844473	46617314	46617334	76223	hg19					enhancer	enh				GCCTCCTCCTCCCGCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	direct	Highly Significant	NA				0.347158786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4060	chr2	46844478	46844498	46617339	46617359	76224	hg19					enhancer	enh				GAACCTAACTGAGCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CRIPT	indirect	Non Significant	NA				0.027914403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4061	chr2	55459235	55459257	55232099	55232121	76225	hg19					enhancer	enh				GTCCTTCACTCACTTCCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.320892291									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4062	chr2	55459261	55459282	55232125	55232146	76226	hg19					enhancer	enh				GCAAAGGGTGCGGGGCACGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.7780723									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4063	chr2	55459285	55459307	55232149	55232171	76227	hg19					enhancer	enh				GACTAGAGCAAATGTTAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.149292159									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4064	chr2	55459318	55459338	55232182	55232202	76228	hg19					enhancer	enh				GGTTTCCGGAGCGTGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	direct	Highly Significant	NA				0.420828813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4065	chr2	55459324	55459346	55232188	55232210	76229	hg19					enhancer	enh				GGAATAATGGTTTCCGGAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.003343773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4066	chr2	55459324	55459345	55232188	55232209	76230	hg19					enhancer	enh				GAATAATGGTTTCCGGAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				0.005698598									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4067	chr2	55459339	55459359	55232203	55232223	76231	hg19					enhancer	enh				GGTAGGATGAAGCGGAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.271421888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4068	chr2	55459339	55459361	55232203	55232225	76232	hg19					enhancer	enh				GAGGTAGGATGAAGCGGAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	direct	Highly Significant	NA				0.208874024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4069	chr2	55459347	55459367	55232211	55232231	76233	hg19					enhancer	enh				GGACTGGAGGTAGGATGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-1.209878617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4070	chr2	55459356	55459378	55232220	55232242	76234	hg19					enhancer	enh				GACTCAGGTGAGGACTGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.409519349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4071	chr2	55459363	55459384	55232227	55232248	76235	hg19					enhancer	enh				GAAAAGGACTCAGGTGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				0.009601553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4072	chr2	55459373	55459394	55232237	55232258	76236	hg19					enhancer	enh				GGTGTTTGGAGAAAAGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	direct	Highly Significant	NA				0.72106937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4073	chr2	55459373	55459393	55232237	55232257	76237	hg19					enhancer	enh				GTGTTTGGAGAAAAGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	direct	Highly Significant	NA				0.324691706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4074	chr2	55459380	55459400	55232244	55232264	76238	hg19					enhancer	enh				GAAGTCGGTGTTTGGAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.115201683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4075	chr2	55459401	55459421	55232265	55232285	76239	hg19					enhancer	enh				GTGCTTAGAGATAGTAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.084357071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4076	chr2	55459408	55459428	55232272	55232292	76240	hg19					enhancer	enh				GAGATAGTAACTAGGGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				0.163428132									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4077	chr2	55459410	55459432	55232274	55232296	76241	hg19					enhancer	enh				GATAGTAACTAGGGAATCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.354551148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4078	chr2	55459414	55459435	55232278	55232299	76242	hg19					enhancer	enh				GTAACTAGGGAATCTGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.231805882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4079	chr2	55459442	55459464	55232306	55232328	76243	hg19					enhancer	enh				GCATCTTGGGACAAGTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLHC1	indirect	Non Significant	NA				-0.412678148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-91139	chr2	61244185	61244206	61017050	61017071	76244	hg19	N/A	enh5561	N/A	N/A	enhancer	enh				GCGGCTTTGTTAGCAAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				0.130146688	PUS10	chr2	60940222	61018255	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3065
enhrx-91139	chr2	61244190	61244212	61017055	61017077	76245	hg19	N/A	enh5561	N/A	N/A	enhancer	enh				GCTGGAGCGGCTTTGTTAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.005763225	PUS10	chr2	60940222	61018255	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3065
enhrx-91139	chr2	61244210	61244231	61017075	61017096	76246	hg19	N/A	enh5561	N/A	N/A	enhancer	enh				GAGAGTTCGTTTCTCTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.473102225	PUS10	chr2	60940222	61018255	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3065
enhrx-lit4080	chr2	61244244	61244264	61017109	61017129	76247	hg19					enhancer	enh				GTGCAGACTGGGTGCAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.421948478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4081	chr2	61244244	61244266	61017109	61017131	76248	hg19					enhancer	enh				GAGTGCAGACTGGGTGCAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.196231272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4082	chr2	61244255	61244275	61017120	61017140	76249	hg19					enhancer	enh				GAGGTGAAGGAGTGCAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.346420567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4083	chr2	61244285	61244307	61017150	61017172	76250	hg19					enhancer	enh				GCCTCACCTTCTCCCCAGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.277442219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4084	chr2	61244294	61244314	61017159	61017179	76251	hg19					enhancer	enh				GGCTCCGGCGTCTGGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.51598606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4085	chr2	61244309	61244331	61017174	61017196	76252	hg19					enhancer	enh				GAAGGGGTTAAATCTCAGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				0.198284389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4086	chr2	61244373	61244395	61017238	61017260	76253	hg19					enhancer	enh				GAACAGAATTGCTAGACGCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.252421093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4087	chr2	61244378	61244399	61017243	61017264	76254	hg19					enhancer	enh				GTCTAGCAATTCTGTTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.002563653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4088	chr2	61244398	61244420	61017263	61017285	76255	hg19					enhancer	enh				GTTCTAAAACGCACGTTTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.300235087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4089	chr2	61244435	61244457	61017300	61017322	76256	hg19					enhancer	enh				GCTCACTTAGTCCTAGCGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	direct	Highly Significant	NA				0.317085982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4090	chr2	61244465	61244485	61017330	61017350	76257	hg19					enhancer	enh				GATTTCCTCTACAAACAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				0.157343237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4091	chr2	61244498	61244518	61017363	61017383	76258	hg19					enhancer	enh				GTAGGGTGAGGTGGCAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.455008198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4092	chr2	61244524	61244545	61017389	61017410	76259	hg19					enhancer	enh				GCACGCACTCCTTCGCTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PUS10	indirect	Non Significant	NA				-0.463220848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4093	chr2	61765190	61765210	61538055	61538075	76260	hg19					enhancer	enh				GGGAAAGTTTAGGCGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	direct	Highly Significant	NA				0.234451015									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4094	chr2	61765273	61765293	61538138	61538158	76261	hg19					enhancer	enh				GCAGCAGCAAAGACTGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-5.653802708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4095	chr2	61765284	61765306	61538149	61538171	76262	hg19					enhancer	enh				GACTGGAACAGGCACCGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-0.002183631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4096	chr2	61765284	61765305	61538149	61538170	76263	hg19					enhancer	enh				GACTGGAACAGGCACCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-0.416679921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4097	chr2	61765304	61765326	61538169	61538191	76264	hg19					enhancer	enh				GCAACAGTAGCTACAGCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-2.063638788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4098	chr2	61765307	61765328	61538172	61538193	76265	hg19					enhancer	enh				GAGCAACAGTAGCTACAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-2.915672161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4099	chr2	61765339	61765361	61538204	61538226	76266	hg19					enhancer	enh				GTAGCTCCCGCTGCTCCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-2.270185031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4100	chr2	61765385	61765405	61538250	61538270	76267	hg19					enhancer	enh				GTTTGAGGCACTAGGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-6.763494125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4101	chr2	61765387	61765407	61538252	61538272	76268	hg19					enhancer	enh				GAGTTTGAGGCACTAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-2.69597527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4102	chr2	61765390	61765412	61538255	61538277	76269	hg19					enhancer	enh				GTTCCGAGTTTGAGGCACTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-2.375552236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4103	chr2	61765393	61765413	61538258	61538278	76270	hg19					enhancer	enh				GGTTCCGAGTTTGAGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-1.055998855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4104	chr2	61765413	61765433	61538278	61538298	76271	hg19					enhancer	enh				GGTTGAAACCGGTTCAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	direct	Highly Significant	NA				0.593825087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4105	chr2	61765444	61765464	61538309	61538329	76272	hg19					enhancer	enh				GGCTGAAAACTCAACCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-1.560967838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4106	chr2	61765470	61765490	61538335	61538355	76273	hg19					enhancer	enh				GCCGCGGAGCGTTTGGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				0.012007447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4107	chr2	61765505	61765525	61538370	61538390	76274	hg19					enhancer	enh				GACCAATAGGAGGGCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-0.025555646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4108	chr2	61765554	61765575	61538419	61538440	76275	hg19					enhancer	enh				GCGCTCGGGCCAATGAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XPO1	indirect	Non Significant	NA				-0.315274845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4109	chr2	63815955	63815977	63588821	63588843	76276	hg19					enhancer	enh				GAACTACACTTCCCGATACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.000473196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4110	chr2	63816017	63816038	63588883	63588904	76277	hg19					enhancer	enh				GAACTGTAGTTTACGCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	direct	Highly Significant	NA				0.287305085									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4111	chr2	63816034	63816054	63588900	63588920	76278	hg19					enhancer	enh				GTTCCCAGAGAGCGCCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.045353544									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4112	chr2	63816051	63816072	63588917	63588938	76279	hg19					enhancer	enh				GAAAAGGCTCCGCTCCCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.012282374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4113	chr2	63816068	63816090	63588934	63588956	76280	hg19					enhancer	enh				GGCGAGCGGTGTTAGCGAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.018383995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4114	chr2	63816068	63816089	63588934	63588955	76281	hg19					enhancer	enh				GCGAGCGGTGTTAGCGAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.266667262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4115	chr2	63816084	63816106	63588950	63588972	76282	hg19					enhancer	enh				GAACTGACTCGGAGAGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.095302138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4116	chr2	63816087	63816108	63588953	63588974	76283	hg19					enhancer	enh				GCCCTCTCCGAGTCAGTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.021158039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4117	chr2	63816108	63816130	63588974	63588996	76284	hg19					enhancer	enh				GAGAGTCAGGTCACCTCTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.085266896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4118	chr2	63816108	63816128	63588974	63588994	76285	hg19					enhancer	enh				GAGTCAGGTCACCTCTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-1.077871793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4119	chr2	63816123	63816145	63588989	63589011	76286	hg19					enhancer	enh				GCAAAATGAGCCTCAGAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.124540347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4120	chr2	63816190	63816212	63589056	63589078	76287	hg19					enhancer	enh				GCCCCGGGTTCCTGCCCACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.42417693									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4121	chr2	63816194	63816216	63589060	63589082	76288	hg19					enhancer	enh				GCCAGAGGTGGGCAGGAACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.866242096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4122	chr2	63816213	63816233	63589079	63589099	76289	hg19					enhancer	enh				GGCCCTCGCGCCCTTGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				0.137721749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4123	chr2	63816218	63816240	63589084	63589106	76290	hg19					enhancer	enh				GAAACCCCACTCAAGGGCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	indirect	Non Significant	NA				-0.953788198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4124	chr2	63816226	63816246	63589092	63589112	76291	hg19					enhancer	enh				GTGCAAGAAACCCCACTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MDH1	direct	Highly Significant	NA				0.280123367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-91370	chr2	64751278	64751299	64524144	64524165	76292	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCAGCTTGCCCGCACCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				0.136867266	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751285	64751306	64524151	64524172	76293	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCCCGCACCCAAAATGGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				0.064121745	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751405	64751425	64524271	64524291	76294	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCAGGTGGCTAGGTCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.404172603	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751423	64751443	64524289	64524309	76295	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GACACGTCACTTCCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	direct	Highly Significant	NA				0.697016472	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751423	64751445	64524289	64524311	76296	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCGCCCGGAAGTGACGTGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.25742822	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751425	64751445	64524291	64524311	76297	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCCCGGAAGTGACGTGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.530028735	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751430	64751451	64524296	64524317	76298	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GAAGTGACGTGTCGGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.426019249	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751572	64751592	64524438	64524458	76299	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCAGCGGTGAAACTCCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.076914431	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751580	64751601	64524446	64524467	76300	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GAAACTCCGGGTGGGCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	indirect	Non Significant	NA				-0.380043543	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-91370	chr2	64751589	64751610	64524455	64524476	76301	hg19	N/A	enh5579	N/A	N/A	enhancer	enh				GCAGCACCATGGACGCCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AFTPH	direct	Highly Significant	NA				0.479247327	AFTPH	chr2	64524298	64593005	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3296
enhrx-lit4125	chr2	65659535	65659556	65432401	65432422	76302	hg19					enhancer	enh				GCCGGGCCAATCACGGTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.639923675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4126	chr2	65659574	65659595	65432440	65432461	76303	hg19					enhancer	enh				GCCTCCCAGGCGCACCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				1.218873301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4127	chr2	65659588	65659608	65432454	65432474	76304	hg19					enhancer	enh				GGCGCCCTGCACCGCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.407837235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4128	chr2	65659610	65659631	65432476	65432497	76305	hg19					enhancer	enh				GTCGAGAGATGGGGCTCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.912908719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4129	chr2	65659622	65659644	65432488	65432510	76306	hg19					enhancer	enh				GTAAATCGGTGGAGTCGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.475814495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4130	chr2	65659638	65659658	65432504	65432524	76307	hg19					enhancer	enh				GAATCCAATATGGAGTAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.947873242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4131	chr2	65659638	65659660	65432504	65432526	76308	hg19					enhancer	enh				GAGAATCCAATATGGAGTAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	indirect	Non Significant	NA				0.045261745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4132	chr2	65659648	65659668	65432514	65432534	76309	hg19					enhancer	enh				GCGGCGGTGAGAATCCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				1.217226162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4133	chr2	65659652	65659672	65432518	65432538	76310	hg19					enhancer	enh				GGATTCTCACCGCCGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.348402397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4134	chr2	65659653	65659675	65432519	65432541	76311	hg19					enhancer	enh				GATTCTCACCGCCGCCAACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.928593067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4135	chr2	65659663	65659685	65432529	65432551	76312	hg19					enhancer	enh				GCCGCCAACAGGAGGAGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	indirect	Non Significant	NA				-1.301320884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4136	chr2	65659666	65659686	65432532	65432552	76313	hg19					enhancer	enh				GCCAACAGGAGGAGGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	indirect	Non Significant	NA				-0.190411505									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4137	chr2	65659690	65659712	65432556	65432578	76314	hg19					enhancer	enh				GGAAGCGATGACGTCTTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.408361344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4138	chr2	65659691	65659712	65432557	65432578	76315	hg19					enhancer	enh				GAAGCGATGACGTCTTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.501644841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4139	chr2	65659699	65659719	65432565	65432585	76316	hg19					enhancer	enh				GACGTCTTCCCAGCGGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPRED2	direct	Highly Significant	NA				0.932009768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4140	chr2	67624276	67624296	67397144	67397164	76317	hg19					enhancer	enh				GGTCCGCGTAAACTGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.473419934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4141	chr2	67624297	67624317	67397165	67397185	76318	hg19					enhancer	enh				GGGTTGTTCGGGTAGTAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				0.072395189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4142	chr2	67624374	67624396	67397242	67397264	76319	hg19					enhancer	enh				GCTGCGGAAGTGCGCGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				0.1102621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4143	chr2	67624396	67624416	67397264	67397284	76320	hg19					enhancer	enh				GCGGAACTGTTAAGGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				-0.046698634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4144	chr2	67624425	67624446	67397293	67397314	76321	hg19					enhancer	enh				GGCCGCTGATTGGCTGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				0.030952843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4145	chr2	67624425	67624445	67397293	67397313	76322	hg19					enhancer	enh				GCCGCTGATTGGCTGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.585124594									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4146	chr2	67624431	67624451	67397299	67397319	76323	hg19					enhancer	enh				GAGGCGGCCGCTGATTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				0.135905897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4147	chr2	67624453	67624475	67397321	67397343	76324	hg19					enhancer	enh				GCGCGCGCCCCACCGACCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.721599155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4148	chr2	67624455	67624475	67397323	67397343	76325	hg19					enhancer	enh				GCGCGCCCCACCGACCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.712344271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4149	chr2	67624467	67624488	67397335	67397356	76326	hg19					enhancer	enh				GACCAAAATGGCGGCTGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	indirect	Non Significant	NA				0.028912999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4150	chr2	67624541	67624561	67397409	67397429	76327	hg19					enhancer	enh				GTGAAAGAAGAAGCGGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.772810223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4151	chr2	67624570	67624592	67397438	67397460	76328	hg19					enhancer	enh				GCCATAGGCAATGAGTCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ETAA1	direct	Highly Significant	NA				0.223909013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-91466	chr2	68289944	68289965	68062812	68062833	76329	hg19	N/A	N/A	N/A	Enhatls98017	enhancer	enh				GTGAGAGACTGCATTCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.252825318	C1D	chr2	68041129	68063009	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3392
enhrx-91466	chr2	68289995	68290015	68062863	68062883	76330	hg19	N/A	N/A	N/A	Enhatls98017	enhancer	enh				GTCTGCCCAGAGGATGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.45430082	C1D	chr2	68041129	68063009	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3392
enhrx-91466	chr2	68290004	68290024	68062872	68062892	76331	hg19	N/A	N/A	N/A	Enhatls98017	enhancer	enh				GGGATTCCCCTGTCATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				0.119873068	C1D	chr2	68041129	68063009	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3392
enhrx-91466	chr2	68290026	68290048	68062894	68062916	76332	hg19	N/A	N/A	N/A	Enhatls98017	enhancer	enh				GAGAGGAAAAGCGGAGTTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.585004242	C1D	chr2	68041129	68063009	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3392
enhrx-91466	chr2	68290028	68290048	68062896	68062916	76333	hg19	N/A	N/A	N/A	Enhatls98017	enhancer	enh				GAGGAAAAGCGGAGTTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.546174396	C1D	chr2	68041129	68063009	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3392
enhrx-lit4152	chr2	68290091	68290111	68062959	68062979	76334	hg19					enhancer	enh				GACTGGAGTCGAAGGCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-1.056579461									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4153	chr2	68290091	68290113	68062959	68062981	76335	hg19					enhancer	enh				GAGACTGGAGTCGAAGGCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-1.995607002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4154	chr2	68290094	68290114	68062962	68062982	76336	hg19					enhancer	enh				GGCCTTCGACTCCAGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-1.877235336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4155	chr2	68290101	68290121	68062969	68062989	76337	hg19					enhancer	enh				GACTCCAGTCTCCCGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-1.777156047									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4156	chr2	68290108	68290130	68062976	68062998	76338	hg19					enhancer	enh				GCCCGACCGCTTTCCGGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-1.260629748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4157	chr2	68290163	68290183	68063031	68063051	76339	hg19					enhancer	enh				GGAAGCGCCGCTCGTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	direct	Highly Significant	NA				0.409999716									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4158	chr2	68290164	68290184	68063032	68063052	76340	hg19					enhancer	enh				GGGAAGCGCCGCTCGTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.320218343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4159	chr2	68290169	68290191	68063037	68063059	76341	hg19					enhancer	enh				GATCATCGGGAAGCGCCGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.152504499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4160	chr2	68290184	68290204	68063052	68063072	76342	hg19					enhancer	enh				GCGAGCAGCGTGAGATCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.157283274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4161	chr2	68290214	68290234	68063082	68063102	76343	hg19					enhancer	enh				GCTCCTTAACTCTTCTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.469751861									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4162	chr2	68290267	68290287	68063135	68063155	76344	hg19					enhancer	enh				GTTGTGGGAGACGATTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	direct	Highly Significant	NA				0.408538312									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4163	chr2	68290274	68290294	68063142	68063162	76345	hg19					enhancer	enh				GAGACGATTGCGGCGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	indirect	Non Significant	NA				-0.65499613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4164	chr2	68290312	68290333	68063180	68063201	76346	hg19					enhancer	enh				GTGAGTGTTAGCCGGGTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C1D	direct	Highly Significant	NA				0.5308205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4165	chr2	68384470	68384490	68157338	68157358	76347	hg19					enhancer	enh				GGTCACAAATTTGGCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.254576625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4166	chr2	68384532	68384552	68157400	68157420	76348	hg19					enhancer	enh				GATCATCGCCCATATCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.214543151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4167	chr2	68384543	68384565	68157411	68157433	76349	hg19					enhancer	enh				GCGATGATCTGAGGCTTCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.208397625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4168	chr2	68384545	68384565	68157413	68157433	76350	hg19					enhancer	enh				GATGATCTGAGGCTTCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.252120753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4169	chr2	68384553	68384574	68157421	68157442	76351	hg19					enhancer	enh				GAGGCTTCTCGAAGGCCGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.243968559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4170	chr2	68384575	68384595	68157443	68157463	76352	hg19					enhancer	enh				GGTGCAGCCAATTTCAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.538228332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4171	chr2	68384585	68384606	68157453	68157474	76353	hg19					enhancer	enh				GGCGGTTGCCGTAGCTGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				0.103096334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4172	chr2	68384585	68384605	68157453	68157473	76354	hg19					enhancer	enh				GCGGTTGCCGTAGCTGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.063780081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4173	chr2	68384635	68384655	68157503	68157523	76355	hg19					enhancer	enh				GGAAACCAGACTCCAAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.334899346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4174	chr2	68384669	68384690	68157537	68157558	76356	hg19					enhancer	enh				GGCAGAATACGGAAAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.690209435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4175	chr2	68384669	68384691	68157537	68157559	76357	hg19					enhancer	enh				GGGCAGAATACGGAAAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.26509519									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4176	chr2	68384669	68384689	68157537	68157557	76358	hg19					enhancer	enh				GCAGAATACGGAAAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.399483796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4177	chr2	68384680	68384700	68157548	68157568	76359	hg19					enhancer	enh				GTATTCTGCCCCAGATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.085969635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4178	chr2	68384702	68384724	68157570	68157592	76360	hg19					enhancer	enh				GCATGTTGGCTGTAGTTATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				0.00326629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4179	chr2	68384724	68384745	68157592	68157613	76361	hg19					enhancer	enh				GAGCGCATCTGGCATTATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	direct	Highly Significant	NA				0.249078203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4180	chr2	68384736	68384757	68157604	68157625	76362	hg19					enhancer	enh				GTGCGATCGCAGGAGCGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.289593938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4181	chr2	68384747	68384767	68157615	68157635	76363	hg19					enhancer	enh				GGAACATTCTGTGCGATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				0.179453616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4182	chr2	68384797	68384817	68157665	68157685	76364	hg19					enhancer	enh				GTGCGAAAGGCAGTGGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-1.855801685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4183	chr2	68384803	68384823	68157671	68157691	76365	hg19					enhancer	enh				GTATGTGTGCGAAAGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.350865369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4184	chr2	68384829	68384850	68157697	68157718	76366	hg19					enhancer	enh				GAGATTACAAAATACTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR92	indirect	Non Significant	NA				-0.14864975									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4185	chr2	69664421	69664442	69437289	69437310	76367	hg19					enhancer	enh				GCAAGGCGGCGACCGCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.047543932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4186	chr2	69664453	69664474	69437321	69437342	76368	hg19					enhancer	enh				GCTCCGAATAGGTGTGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.053899091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4187	chr2	69664454	69664474	69437322	69437342	76369	hg19					enhancer	enh				GCTCCGAATAGGTGTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.149056643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4188	chr2	69664465	69664486	69437333	69437354	76370	hg19					enhancer	enh				GACGAGCCTGGAGCTCCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	direct	Highly Significant	NA				0.360384673									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4189	chr2	69664478	69664499	69437346	69437367	76371	hg19					enhancer	enh				GCAGGCGGTAGGTGACGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	direct	Highly Significant	NA				0.993115388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4190	chr2	69664483	69664505	69437351	69437373	76372	hg19					enhancer	enh				GTCACCTACCGCCTGCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	direct	Highly Significant	NA				0.348206021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4191	chr2	69664494	69664515	69437362	69437383	76373	hg19					enhancer	enh				GTTGCCGCCGGGCTGCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-0.682640115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4192	chr2	69664497	69664518	69437365	69437386	76374	hg19					enhancer	enh				GCTGTTGCCGCCGGGCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-0.806507816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4193	chr2	69664506	69664527	69437374	69437395	76375	hg19					enhancer	enh				GGAGCTGCGGCTGTTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.091283947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4194	chr2	69664506	69664526	69437374	69437394	76376	hg19					enhancer	enh				GAGCTGCGGCTGTTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	direct	Highly Significant	NA				0.325470903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4195	chr2	69664516	69664538	69437384	69437406	76377	hg19					enhancer	enh				GCCGCAGCTCCCCAGCCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.045066933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4196	chr2	69664539	69664561	69437407	69437429	76378	hg19					enhancer	enh				GGCCGTCGCCGCCATCTTAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-0.083171068									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4197	chr2	69664540	69664561	69437408	69437429	76379	hg19					enhancer	enh				GCCGTCGCCGCCATCTTAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				0.116791745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4198	chr2	69664550	69664570	69437418	69437438	76380	hg19					enhancer	enh				GGCACTCCGGACTAAGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-1.02214868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4199	chr2	69664686	69664706	69437554	69437574	76381	hg19					enhancer	enh				GTGCGGTGGCCTACGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-0.014702049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4200	chr2	69664698	69664718	69437566	69437586	76382	hg19					enhancer	enh				GCCTGCAAACCTCGGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NFU1	indirect	Non Significant	NA				-0.570231157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-91596	chr2	69870672	69870692	69643540	69643560	76383	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GATGCCGCCTCGAGGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.519793565	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-91596	chr2	69870675	69870697	69643543	69643565	76384	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GCCAGGATGCCGCCTCGAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.568058843	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-91596	chr2	69870678	69870700	69643546	69643568	76385	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GCTGCCAGGATGCCGCCTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	direct	Highly Significant	NA				0.408064014	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-91596	chr2	69870680	69870700	69643548	69643568	76386	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GCTGCCAGGATGCCGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.302339985	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-91596	chr2	69870695	69870717	69643563	69643585	76387	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GCAGCACCCACTTGAGACGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.120219116	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-91596	chr2	69870698	69870720	69643566	69643588	76388	hg19	N/A	N/A	N/A	Enhatls98149	enhancer	enh				GCACCCACTTGAGACGGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				0.10833759	AAK1	chr2	69457996	69643739	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3522
enhrx-lit4201	chr2	69870704	69870725	69643572	69643593	76389	hg19					enhancer	enh				GGCCGCCGAGCCGTCTCAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				0.13880764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4202	chr2	69870704	69870724	69643572	69643592	76390	hg19					enhancer	enh				GCCGCCGAGCCGTCTCAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	direct	Highly Significant	NA				0.632284422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4203	chr2	69870740	69870761	69643608	69643629	76391	hg19					enhancer	enh				GCCGTGACAATGTCGCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.511856404									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4204	chr2	69870744	69870765	69643612	69643633	76392	hg19					enhancer	enh				GGCGGCCGTGACAATGTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.095956907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4205	chr2	69870744	69870764	69643612	69643632	76393	hg19					enhancer	enh				GCGGCCGTGACAATGTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.132853357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4206	chr2	69870745	69870765	69643613	69643633	76394	hg19					enhancer	enh				GGCGGCCGTGACAATGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.149102241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4207	chr2	69870767	69870789	69643635	69643657	76395	hg19					enhancer	enh				GCCGGCCTGCGACGCAGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.458672586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4208	chr2	69870771	69870793	69643639	69643661	76396	hg19					enhancer	enh				GCCTCTTCTCTGCGTCGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	direct	Highly Significant	NA				0.464529937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4209	chr2	69870775	69870796	69643643	69643664	76397	hg19					enhancer	enh				GCCGCCTCTTCTCTGCGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.067655581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4210	chr2	69870790	69870810	69643658	69643678	76398	hg19					enhancer	enh				GGCGGCGCTGCAGCGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.48379434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4211	chr2	69870791	69870812	69643659	69643680	76399	hg19					enhancer	enh				GCGGCGCTGCAGCGAGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	direct	Highly Significant	NA				0.488635338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4212	chr2	69870802	69870822	69643670	69643690	76400	hg19					enhancer	enh				GCGAGAGCCGGGGCCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.211721452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4213	chr2	69870936	69870956	69643804	69643824	76401	hg19					enhancer	enh				GCCGCCGGAAGTGCCCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	AAK1	indirect	Non Significant	NA				-0.033727608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4214	chr2	70314423	70314443	70087291	70087311	76402	hg19					enhancer	enh				GTGAAAATGAAGCGCACGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-0.80746733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4215	chr2	70314549	70314569	70087417	70087437	76403	hg19					enhancer	enh				GCAAGCACTTCCGGGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-0.812097459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4216	chr2	70314570	70314590	70087438	70087458	76404	hg19					enhancer	enh				GGGTACGCGGGGTTGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	direct	Highly Significant	NA				0.950988467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4217	chr2	70314603	70314624	70087471	70087492	76405	hg19					enhancer	enh				GCAGCCTCGGCGGTCTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	direct	Highly Significant	NA				0.425671238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4218	chr2	70314605	70314625	70087473	70087493	76406	hg19					enhancer	enh				GGCAGCCTCGGCGGTCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	direct	Highly Significant	NA				0.483624446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4219	chr2	70314614	70314634	70087482	70087502	76407	hg19					enhancer	enh				GACTCCGGCGGCAGCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-1.087195725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4220	chr2	70314617	70314637	70087485	70087505	76408	hg19					enhancer	enh				GGCGACTCCGGCGGCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-0.61786088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4221	chr2	70314704	70314726	70087572	70087594	76409	hg19					enhancer	enh				GCCCGCCCCTGCGACTACGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	direct	Highly Significant	NA				0.721376347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4222	chr2	70314713	70314733	70087581	70087601	76410	hg19					enhancer	enh				GAGGCCGCAGCGTAGTCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-1.108208347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4223	chr2	70314757	70314777	70087625	70087645	76411	hg19					enhancer	enh				GGCCCTCGCTCGCCTCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	indirect	Non Significant	NA				-0.126102045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4224	chr2	70314772	70314792	70087640	70087660	76412	hg19					enhancer	enh				GGCCCAAAACTGCCGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCBP1	direct	Highly Significant	NA				0.653676821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4225	chr2	70485223	70485244	70258091	70258112	76413	hg19					enhancer	enh				GCGGAGCGCGCAGCCGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.310417935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4226	chr2	70485228	70485248	70258096	70258116	76414	hg19					enhancer	enh				GCGCGCAGCCGCGCAGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.211072973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4227	chr2	70485239	70485259	70258107	70258127	76415	hg19					enhancer	enh				GCAGTCCTCCCACCGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.21215206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4228	chr2	70485270	70485291	70258138	70258159	76416	hg19					enhancer	enh				GGCCAGCTGCAGAGCTTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.033945685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4229	chr2	70485271	70485291	70258139	70258159	76417	hg19					enhancer	enh				GCCAGCTGCAGAGCTTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.229268344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4230	chr2	70485275	70485295	70258143	70258163	76418	hg19					enhancer	enh				GCCTCCACAAGCTCTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				0.049858676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4231	chr2	70485278	70485298	70258146	70258166	76419	hg19					enhancer	enh				GCAGAGCTTGTGGAGGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.07831814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4232	chr2	70485292	70485312	70258160	70258180	76420	hg19					enhancer	enh				GGCCATGGGGCGCGTCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				0.133673315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4233	chr2	70485297	70485318	70258165	70258186	76421	hg19					enhancer	enh				GCTCCGCGACGACGCGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.0456839									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4234	chr2	70485313	70485335	70258181	70258203	76422	hg19					enhancer	enh				GGAGCTCGTCTCCTCGCTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.214366662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4235	chr2	70485314	70485335	70258182	70258203	76423	hg19					enhancer	enh				GAGCTCGTCTCCTCGCTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.398377384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4236	chr2	70485340	70485361	70258208	70258229	76424	hg19					enhancer	enh				GTGGCTGTTGCTGTGCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.389456915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4237	chr2	70485352	70485373	70258220	70258241	76425	hg19					enhancer	enh				GTGCAGCTGCGGATGCCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	indirect	Non Significant	NA				-0.317472014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4238	chr2	70485372	70485393	70258240	70258261	76426	hg19					enhancer	enh				GAGCACGCAGCTCGGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.607237425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4239	chr2	70485389	70485410	70258257	70258278	76427	hg19					enhancer	enh				GCTCCGCCAGATAAAATCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.230095807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-91657	chr2	70485398	70485418	70258266	70258286	76428	hg19	N/A	N/A	N/A	Enhatls98219	enhancer	enh				GATAAAATCGGTAGGCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PCYOX1	direct	Highly Significant	NA				0.435819307	PCYOX1	chr2	70257385	70281185	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3583
enhrx-91664	chr2	70529046	70529066	70301914	70301934	76429	hg19	N/A	N/A	N/A	Enhatls98226	enhancer	enh				GAAGATGCAGGTAGCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.317866683	FAM136A	chr2	70295975	70302067	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3590
enhrx-lit4240	chr2	70529085	70529105	70301953	70301973	76430	hg19					enhancer	enh				GGAGTCCATGGTGAAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.768053851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4241	chr2	70529098	70529120	70301966	70301988	76431	hg19					enhancer	enh				GGACTCCACCGCCTCCTGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.433498705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4242	chr2	70529099	70529120	70301967	70301988	76432	hg19					enhancer	enh				GACTCCACCGCCTCCTGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.114677386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4243	chr2	70529115	70529135	70301983	70302003	76433	hg19					enhancer	enh				GCTGCAGCAGCTCCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-1.340953633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4244	chr2	70529115	70529137	70301983	70302005	76434	hg19					enhancer	enh				GAGCTGCAGCAGCTCCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.537268197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4245	chr2	70529121	70529142	70301989	70302010	76435	hg19					enhancer	enh				GGAGCTGCTGCAGCTCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.794513868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4246	chr2	70529122	70529142	70301990	70302010	76436	hg19					enhancer	enh				GAGCTGCTGCAGCTCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.908496601									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4247	chr2	70529167	70529187	70302035	70302055	76437	hg19					enhancer	enh				GCTCCGCGCCGGCGCCCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.729833495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4248	chr2	70529172	70529193	70302040	70302061	76438	hg19					enhancer	enh				GCGCCGGCGCCCATATGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-1.218448279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4249	chr2	70529173	70529194	70302041	70302062	76439	hg19					enhancer	enh				GATTCCATATGGGCGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-1.7121296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4250	chr2	70529178	70529200	70302046	70302068	76440	hg19					enhancer	enh				GCGCCCATATGGAATCGGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	direct	Highly Significant	NA				0.392542495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4251	chr2	70529180	70529200	70302048	70302068	76441	hg19					enhancer	enh				GCCCATATGGAATCGGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.600994042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4252	chr2	70529185	70529206	70302053	70302074	76442	hg19					enhancer	enh				GGCCCGTACGCCGATTCCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.585954368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4253	chr2	70529185	70529205	70302053	70302073	76443	hg19					enhancer	enh				GCCCGTACGCCGATTCCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM136A	indirect	Non Significant	NA				-0.790112662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4254	chr2	71357620	71357640	71130490	71130510	76444	hg19					enhancer	enh				GCGCGAGCGCTTTCGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.479330406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4255	chr2	71357663	71357684	71130533	71130554	76445	hg19					enhancer	enh				GAGTCCGGAACCTGTGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.111361879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4256	chr2	71357676	71357697	71130546	71130567	76446	hg19					enhancer	enh				GCCGAAAGTTCCGCGGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				0.151337913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4257	chr2	71357684	71357706	71130554	71130576	76447	hg19					enhancer	enh				GATTTCAGAGCCGAAAGTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				0.170801401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4258	chr2	71357714	71357735	71130584	71130605	76448	hg19					enhancer	enh				GCTGGGCGCATCTTTGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				0.186554328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4259	chr2	71357733	71357753	71130603	71130623	76449	hg19					enhancer	enh				GGAGCCGCCCGGAAACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.941904142									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4260	chr2	71357733	71357754	71130603	71130624	76450	hg19					enhancer	enh				GGGAGCCGCCCGGAAACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.623370694									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4261	chr2	71357775	71357796	71130645	71130666	76451	hg19					enhancer	enh				GTCGGGAGTTGCTGACAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.70251156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4262	chr2	71357785	71357805	71130655	71130675	76452	hg19					enhancer	enh				GCTGACAGCCATGGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.903826452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4263	chr2	71357788	71357810	71130658	71130680	76453	hg19					enhancer	enh				GACAGCCATGGCGCCGCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-2.006065726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4264	chr2	71357796	71357817	71130666	71130687	76454	hg19					enhancer	enh				GACGCCAGACCTGCGGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-2.569073069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4265	chr2	71357797	71357819	71130667	71130689	76455	hg19					enhancer	enh				GGCGCCGCAGGTCTGGCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.332647363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4266	chr2	71357798	71357819	71130668	71130689	76456	hg19					enhancer	enh				GCGCCGCAGGTCTGGCGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.583577526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4267	chr2	71357804	71357825	71130674	71130695	76457	hg19					enhancer	enh				GGTCCGTCGACGCCAGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-2.310193298									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4268	chr2	71357804	71357824	71130674	71130694	76458	hg19					enhancer	enh				GTCCGTCGACGCCAGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-2.101345207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4269	chr2	71357811	71357831	71130681	71130701	76459	hg19					enhancer	enh				GGCGTCGACGGACCCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.367924223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4270	chr2	71357828	71357848	71130698	71130718	76460	hg19					enhancer	enh				GAGCGGTGTCTGACGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.893709479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4271	chr2	71357843	71357864	71130713	71130734	76461	hg19					enhancer	enh				GAAGTCGGCAAAGCCACGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.531801389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4272	chr2	71357859	71357879	71130729	71130749	76462	hg19					enhancer	enh				GAAGCACTCGGGCCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-1.01530677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4273	chr2	71357859	71357880	71130729	71130750	76463	hg19					enhancer	enh				GGAAGCACTCGGGCCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MPHOSPH10	indirect	Non Significant	NA				-0.111087147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4274	chr2	73114473	73114493	72887344	72887364	76464	hg19					enhancer	enh				GGACCGCTACGGGTGTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.573032444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4275	chr2	73114513	73114535	72887384	72887406	76465	hg19					enhancer	enh				GCACCCGAGACCAGGCAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.349705295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4276	chr2	73114516	73114536	72887387	72887407	76466	hg19					enhancer	enh				GGCACCCGAGACCAGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.069121826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4277	chr2	73114519	73114539	72887390	72887410	76467	hg19					enhancer	enh				GCTGGCACCCGAGACCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	direct	Highly Significant	NA				0.475938711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4278	chr2	73114523	73114544	72887394	72887415	76468	hg19					enhancer	enh				GGTCTCGGGTGCCAGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	direct	Highly Significant	NA				0.253618864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4279	chr2	73114524	73114544	72887395	72887415	76469	hg19					enhancer	enh				GTCTCGGGTGCCAGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				0.060791704									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4280	chr2	73114533	73114555	72887404	72887426	76470	hg19					enhancer	enh				GCCAGCGCCGCCGGCGGAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.77702396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4281	chr2	73114542	73114562	72887413	72887433	76471	hg19					enhancer	enh				GCCGGCGGAGAACAGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.242305601									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4282	chr2	73114546	73114566	72887417	72887437	76472	hg19					enhancer	enh				GCGGAGAACAGGAGCATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-1.535786292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4283	chr2	73114578	73114599	72887449	72887470	76473	hg19					enhancer	enh				GCGTGCTGTGTGCTTGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.070885907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4284	chr2	73114580	73114601	72887451	72887472	76474	hg19					enhancer	enh				GTGCTGTGTGCTTGCTGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	direct	Highly Significant	NA				0.30288385									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4285	chr2	73114589	73114611	72887460	72887482	76475	hg19					enhancer	enh				GCTTGCTGACCGGGGCCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.208685986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4286	chr2	73114601	73114621	72887472	72887492	76476	hg19					enhancer	enh				GGGCCTCCCGCGGCTTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.364357855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4287	chr2	73114611	73114632	72887482	72887503	76477	hg19					enhancer	enh				GCCAGCGTCCGGCCGAAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.803852151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4288	chr2	73114619	73114640	72887490	72887511	76478	hg19					enhancer	enh				GCCGGACGCTGGCCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SPR	indirect	Non Significant	NA				-0.488434081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4289	chr2	73441297	73441319	73214169	73214191	76479	hg19					enhancer	enh				GCCTCAGGGGCACTCTCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.073985995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4290	chr2	73441334	73441355	73214206	73214227	76480	hg19					enhancer	enh				GGGGTGTGGCCTCTCAGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	direct	Highly Significant	NA				0.580632377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4291	chr2	73441339	73441360	73214211	73214232	76481	hg19					enhancer	enh				GTGGCCTCTCAGGTCGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.249708205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4292	chr2	73441339	73441359	73214211	73214231	76482	hg19					enhancer	enh				GTGGCCTCTCAGGTCGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.010825059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4293	chr2	73441354	73441375	73214226	73214247	76483	hg19					enhancer	enh				GAGGCGGGGTTAAGGGTCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.807453587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4294	chr2	73441360	73441381	73214232	73214253	76484	hg19					enhancer	enh				GGGTTAAGGGTCATAAGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.523699908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4295	chr2	73441361	73441381	73214233	73214253	76485	hg19					enhancer	enh				GGTTAAGGGTCATAAGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.517735651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4296	chr2	73441377	73441398	73214249	73214270	76486	hg19					enhancer	enh				GCGGAGGCGCGCCCAAGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.620430126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4297	chr2	73441404	73441424	73214276	73214296	76487	hg19					enhancer	enh				GGAGAACACGTCGCACATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.220397154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4298	chr2	73441407	73441427	73214279	73214299	76488	hg19					enhancer	enh				GAAGGAGAACACGTCGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.059566917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4299	chr2	73441410	73441431	73214282	73214303	76489	hg19					enhancer	enh				GCGACGTGTTCTCCTTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	direct	Highly Significant	NA				0.250836665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4300	chr2	73441415	73441437	73214287	73214309	76490	hg19					enhancer	enh				GTGTTCTCCTTCTGCGTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.359671761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4301	chr2	73441417	73441437	73214289	73214309	76491	hg19					enhancer	enh				GTTCTCCTTCTGCGTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.093874852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4302	chr2	73441425	73441446	73214297	73214318	76492	hg19					enhancer	enh				GGCCCGCCACGCCCACGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	direct	Highly Significant	NA				0.38106819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4303	chr2	73441425	73441445	73214297	73214317	76493	hg19					enhancer	enh				GCCCGCCACGCCCACGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				0.004949507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4304	chr2	73441447	73441469	73214319	73214341	76494	hg19					enhancer	enh				GACTTCCACGGAGACCCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.068765526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4305	chr2	73441461	73441481	73214333	73214353	76495	hg19					enhancer	enh				GCTCACGAAACGGACTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				0.060189959									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4306	chr2	73441466	73441488	73214338	73214360	76496	hg19					enhancer	enh				GTCCGTTTCGTGAGCAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SMYD5	indirect	Non Significant	NA				-0.626955547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4307	chr2	73460209	73460229	73233081	73233101	76497	hg19					enhancer	enh				GGCCCACGGTGAGCGGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				0.006503446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4308	chr2	73460216	73460236	73233088	73233108	76498	hg19					enhancer	enh				GCGTCGCGGCCCACGGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.626940675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4309	chr2	73460271	73460292	73233143	73233164	76499	hg19					enhancer	enh				GCGGCGCCGGGGACCATCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	direct	Highly Significant	NA				0.29220625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4310	chr2	73460280	73460302	73233152	73233174	76500	hg19					enhancer	enh				GCCCGGCCCTGGAGATGGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				0.16543414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4311	chr2	73460287	73460307	73233159	73233179	76501	hg19					enhancer	enh				GCCGGGCCCGGCCCTGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-1.593912687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4312	chr2	73460304	73460325	73233176	73233197	76502	hg19					enhancer	enh				GAGGAAACGCGGCGCCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.462823526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4313	chr2	73460305	73460325	73233177	73233197	76503	hg19					enhancer	enh				GAGGAAACGCGGCGCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				0.168305532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4314	chr2	73460309	73460329	73233181	73233201	76504	hg19					enhancer	enh				GCGAGAGGAAACGCGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.349288467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4315	chr2	73460310	73460330	73233182	73233202	76505	hg19					enhancer	enh				GGCGAGAGGAAACGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	direct	Highly Significant	NA				0.276059008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4316	chr2	73460334	73460356	73233206	73233228	76506	hg19					enhancer	enh				GTCCTGCGAGCGACGCGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				0.015416742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4317	chr2	73460336	73460356	73233208	73233228	76507	hg19					enhancer	enh				GTCCTGCGAGCGACGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.260429325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4318	chr2	73460339	73460359	73233211	73233231	76508	hg19					enhancer	enh				GAAGTCCTGCGAGCGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.151317222									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4319	chr2	73460353	73460375	73233225	73233247	76509	hg19					enhancer	enh				GACTTCAGCCTGACAGCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.143860824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4320	chr2	73460384	73460406	73233256	73233278	76510	hg19					enhancer	enh				GCCCACATACCCGCTCTCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-0.02675239									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4321	chr2	73460396	73460416	73233268	73233288	76511	hg19					enhancer	enh				GTCCAGCCCGCGGCGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	indirect	Non Significant	NA				-1.231245116									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4322	chr2	73460501	73460522	73233373	73233394	76512	hg19					enhancer	enh				GCTCCACTTCTCTCGACCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PRADC1	direct	Highly Significant	NA				0.284943894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4323	chr2	74405874	74405894	74178747	74178767	76513	hg19					enhancer	enh				GCGGACCGTCCTTAGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				0.085656816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4324	chr2	74405902	74405922	74178775	74178795	76514	hg19					enhancer	enh				GAAGCCGGGCCGCCGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.131385405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4325	chr2	74405914	74405936	74178787	74178809	76515	hg19					enhancer	enh				GAAACCCGGCTCCGAGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.104104631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4326	chr2	74405920	74405940	74178793	74178813	76516	hg19					enhancer	enh				GCCAGAAACCCGGCTCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				0.098942103									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4327	chr2	74405930	74405950	74178803	74178823	76517	hg19					enhancer	enh				GCTCGCAGCGGCCAGAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.210258422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4328	chr2	74405930	74405951	74178803	74178824	76518	hg19					enhancer	enh				GGCTCGCAGCGGCCAGAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.301028236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4329	chr2	74405941	74405962	74178814	74178835	76519	hg19					enhancer	enh				GCTGCGAGCCTTTGCAAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	direct	Highly Significant	NA				0.422795923									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4330	chr2	74405952	74405973	74178825	74178846	76520	hg19					enhancer	enh				GGCGGGCGCCGAGGTTTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	direct	Highly Significant	NA				0.404963852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4331	chr2	74405952	74405972	74178825	74178845	76521	hg19					enhancer	enh				GCGGGCGCCGAGGTTTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	direct	Highly Significant	NA				0.426744713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4332	chr2	74405987	74406008	74178860	74178881	76522	hg19					enhancer	enh				GCATTTCGGGTCTGCGAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	direct	Highly Significant	NA				0.530280482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4333	chr2	74405992	74406014	74178865	74178887	76523	hg19					enhancer	enh				GGTTCCGCATTTCGGGTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.166030767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4334	chr2	74405992	74406013	74178865	74178886	76524	hg19					enhancer	enh				GTTCCGCATTTCGGGTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				0.135229133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4335	chr2	74406027	74406047	74178900	74178920	76525	hg19					enhancer	enh				GAGCTAAGGTTTCGCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				0.037356623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4336	chr2	74406029	74406051	74178902	74178924	76526	hg19					enhancer	enh				GCTAAGGTTTCGCTGCGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				0.111284134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4337	chr2	74406083	74406104	74178956	74178977	76527	hg19					enhancer	enh				GATTGGCCGAGTTCTAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOB1A	indirect	Non Significant	NA				-0.526222895									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-92044	chr2	74618910	74618931	74391783	74391804	76528	hg19	N/A	N/A	N/A	Enhatls98619	enhancer	enh				GCCTCCGTACCTGCACTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-0.092984675	DCTN1	chr2	74361153	74392087	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3970
enhrx-92044	chr2	74618914	74618936	74391787	74391809	76529	hg19	N/A	N/A	N/A	Enhatls98619	enhancer	enh				GCCCCTCACAGTGCAGGTACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-0.960437593	DCTN1	chr2	74361153	74392087	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3970
enhrx-92044	chr2	74618917	74618938	74391790	74391811	76530	hg19	N/A	N/A	N/A	Enhatls98619	enhancer	enh				GAGCCCCTCACAGTGCAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-1.000898527	DCTN1	chr2	74361153	74392087	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	3970
enhrx-lit4338	chr2	74618922	74618944	74391795	74391817	76531	hg19					enhancer	enh				GGCGCGGAGCCCCTCACAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				0.020586661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4339	chr2	74618922	74618943	74391795	74391816	76532	hg19					enhancer	enh				GCGCGGAGCCCCTCACAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-0.235520568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4340	chr2	74618957	74618979	74391830	74391852	76533	hg19					enhancer	enh				GTCTTGGGCGTCGGTCGTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-1.630119789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4341	chr2	74618958	74618979	74391831	74391852	76534	hg19					enhancer	enh				GTCTTGGGCGTCGGTCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-2.400357552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4342	chr2	74618963	74618985	74391836	74391858	76535	hg19					enhancer	enh				GACCGACGCCCAAGACCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-1.111265749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4343	chr2	74618963	74618983	74391836	74391856	76536	hg19					enhancer	enh				GACCGACGCCCAAGACCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-1.588047783									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4344	chr2	74618968	74618990	74391841	74391863	76537	hg19					enhancer	enh				GGCCCCGCAGGGTCTTGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-1.787825002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4345	chr2	74618968	74618989	74391841	74391862	76538	hg19					enhancer	enh				GCCCCGCAGGGTCTTGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	indirect	Non Significant	NA				-2.842295942									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4346	chr2	74619004	74619025	74391877	74391898	76539	hg19					enhancer	enh				GTCGGGCAGCCCACGAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DCTN1	direct	Highly Significant	NA				0.512271326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4347	chr2	74692406	74692426	74465279	74465299	76540	hg19					enhancer	enh				GAGAGGCGGCAGTGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	indirect	Non Significant	NA				0.185845104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4348	chr2	74692464	74692486	74465337	74465359	76541	hg19					enhancer	enh				GCTAACCGGACGGTGGTCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	indirect	Non Significant	NA				-0.105699248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4349	chr2	74692465	74692486	74465338	74465359	76542	hg19					enhancer	enh				GCTAACCGGACGGTGGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	direct	Highly Significant	NA				0.520683088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4350	chr2	74692473	74692495	74465346	74465368	76543	hg19					enhancer	enh				GCAGGTGTCGCTAACCGGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	indirect	Non Significant	NA				-0.459262958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4351	chr2	74692476	74692496	74465349	74465369	76544	hg19					enhancer	enh				GGCAGGTGTCGCTAACCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	indirect	Non Significant	NA				-0.411585788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4352	chr2	74692480	74692500	74465353	74465373	76545	hg19					enhancer	enh				GGCTGGCAGGTGTCGCTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MOGS	indirect	Non Significant	NA				-0.318783048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4353	chr2	74726785	74726805	74499658	74499678	76546	hg19					enhancer	enh				GAGGAGGGGCACACGGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				0.001802521									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4354	chr2	74726827	74726849	74499700	74499722	76547	hg19					enhancer	enh				GCTCCAGATCCACCGCGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.418994788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4355	chr2	74726844	74726865	74499717	74499738	76548	hg19					enhancer	enh				GGAGCTCCTAGATGTCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.969418855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4356	chr2	74726845	74726865	74499718	74499738	76549	hg19					enhancer	enh				GAGCTCCTAGATGTCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.069536683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4357	chr2	74726857	74726878	74499730	74499751	76550	hg19					enhancer	enh				GTCCGGGGAGGGTATTTCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.269106479									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4358	chr2	74726862	74726882	74499735	74499755	76551	hg19					enhancer	enh				GGGAGGGTATTTCTACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.230503707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4359	chr2	74726863	74726883	74499736	74499756	76552	hg19					enhancer	enh				GGAGGGTATTTCTACAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.497159296									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4360	chr2	74726868	74726888	74499741	74499761	76553	hg19					enhancer	enh				GTATTTCTACAGGCTGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				0.002071048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4361	chr2	74726908	74726930	74499781	74499803	76554	hg19					enhancer	enh				GACCAAACTACCCACCAGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.210133236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4362	chr2	74726908	74726929	74499781	74499802	76555	hg19					enhancer	enh				GACCAAACTACCCACCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.225585789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4363	chr2	74726922	74726942	74499795	74499815	76556	hg19					enhancer	enh				GCCCCGTGGCCCTGCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.420329263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4364	chr2	74726925	74726945	74499798	74499818	76557	hg19					enhancer	enh				GCAGCCCCGTGGCCCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				0.198159714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4365	chr2	74726932	74726954	74499805	74499827	76558	hg19					enhancer	enh				GCCACGGGGCTGCTCCGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.274762886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4366	chr2	74726956	74726978	74499829	74499851	76559	hg19					enhancer	enh				GGGCGCTGCACCGTGCACAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	direct	Highly Significant	NA				0.227225289									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4367	chr2	74726957	74726978	74499830	74499851	76560	hg19					enhancer	enh				GGCGCTGCACCGTGCACAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.216030303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4368	chr2	74726958	74726978	74499831	74499851	76561	hg19					enhancer	enh				GCGCTGCACCGTGCACAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.509759522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4369	chr2	74726963	74726983	74499836	74499856	76562	hg19					enhancer	enh				GCACCGTGCACAGTCAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.415056422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4370	chr2	74726989	74727009	74499862	74499882	76563	hg19					enhancer	enh				GCATACAGCGTCTGGAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-0.241268006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4371	chr2	74726997	74727018	74499870	74499891	76564	hg19					enhancer	enh				GAGTCGGCGGCATACAGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LBX2	indirect	Non Significant	NA				-1.424878854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4372	chr2	74881367	74881388	74654240	74654261	76565	hg19					enhancer	enh				GCTGAGGGATGAAACACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.231899584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4373	chr2	74881383	74881405	74654256	74654278	76566	hg19					enhancer	enh				GTCCGGCTCAGCCTGAGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				0.139734343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4374	chr2	74881393	74881414	74654266	74654287	76567	hg19					enhancer	enh				GCTGAGCCGGACCGAGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.438437571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4375	chr2	74881406	74881426	74654279	74654299	76568	hg19					enhancer	enh				GAGCCGAGAGGACCCGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.06478881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4376	chr2	74881422	74881443	74654295	74654316	76569	hg19					enhancer	enh				GCTACTGGCCTCGGCCCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.208903989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4377	chr2	74881427	74881447	74654300	74654320	76570	hg19					enhancer	enh				GGCCGAGGCCAGTAGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.325640962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4378	chr2	74881432	74881452	74654305	74654325	76571	hg19					enhancer	enh				GGCCCCGGGGCTACTGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.499173744									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4379	chr2	74881528	74881550	74654401	74654423	76572	hg19					enhancer	enh				GTAGGCTGCCCGGGACCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				0.103462512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4380	chr2	74881533	74881553	74654406	74654426	76573	hg19					enhancer	enh				GCTGTAGGCTGCCCGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.583188424									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4381	chr2	74881533	74881554	74654406	74654427	76574	hg19					enhancer	enh				GGCTGTAGGCTGCCCGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.622858698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4382	chr2	74881540	74881560	74654413	74654433	76575	hg19					enhancer	enh				GGGCGAGGCTGTAGGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.257034256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4383	chr2	74881560	74881580	74654433	74654453	76576	hg19					enhancer	enh				GCCAGCAGCAGTAGCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.437955311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4384	chr2	74881565	74881585	74654438	74654458	76577	hg19					enhancer	enh				GCACCGCCAGCAGCAGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.272485678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4385	chr2	74881574	74881594	74654447	74654467	76578	hg19					enhancer	enh				GCTGGCGGTGCTGAGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	direct	Highly Significant	NA				0.554402938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4386	chr2	74881613	74881634	74654486	74654507	76579	hg19					enhancer	enh				GAGGTTCTGGGCACCGAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.512084883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4387	chr2	74881614	74881634	74654487	74654507	76580	hg19					enhancer	enh				GAGGTTCTGGGCACCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.150777376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-92109	chr2	74881634	74881656	74654507	74654529	76581	hg19	N/A	N/A	N/A	Enhatls98687	enhancer	enh				GCTTCCAATCTCTGGTAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.110110895	SEMA4F	chr2	74654227	74683853	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4035
enhrx-92109	chr2	74881641	74881661	74654514	74654534	76582	hg19	N/A	N/A	N/A	Enhatls98687	enhancer	enh				GTCCGCGCCTTACCAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SEMA4F	indirect	Non Significant	NA				-0.039727994	SEMA4F	chr2	74654227	74683853	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4035
enhrx-lit4388	chr2	75185725	75185746	74958598	74958619	76583	hg19					enhancer	enh				GCCTCCAGCCCGCGCGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.109388563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4389	chr2	75185732	75185754	74958605	74958627	76584	hg19					enhancer	enh				GCAGGCCCTTTCCCGCGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.017656107									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4390	chr2	75185736	75185756	74958609	74958629	76585	hg19					enhancer	enh				GCGCAGGCCCTTTCCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				0.099932381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4391	chr2	75185737	75185757	74958610	74958630	76586	hg19					enhancer	enh				GGCGCAGGCCCTTTCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.195042578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4392	chr2	75185752	75185774	74958625	74958647	76587	hg19					enhancer	enh				GCGCCGCATGCGCGCGCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	direct	Highly Significant	NA				0.375154892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4393	chr2	75185754	75185774	74958627	74958647	76588	hg19					enhancer	enh				GCCGCATGCGCGCGCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.443128454									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4394	chr2	75185757	75185777	74958630	74958650	76589	hg19					enhancer	enh				GCATGCGCGCGCACAGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	direct	Highly Significant	NA				0.254538991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4395	chr2	75185776	75185798	74958649	74958671	76590	hg19					enhancer	enh				GCGGCCGCGCGCAGCACGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.125752846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4396	chr2	75185778	75185798	74958651	74958671	76591	hg19					enhancer	enh				GGCCGCGCGCAGCACGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.433311075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4397	chr2	75185782	75185802	74958655	74958675	76592	hg19					enhancer	enh				GCGCGCAGCACGCTCAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	direct	Highly Significant	NA				0.337474013									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4398	chr2	75185783	75185803	74958656	74958676	76593	hg19					enhancer	enh				GGCCTTGAGCGTGCTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.11851559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4399	chr2	75185789	75185810	74958662	74958683	76594	hg19					enhancer	enh				GCACGCTCAAGGCCGGGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-1.686293147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4400	chr2	75185793	75185813	74958666	74958686	76595	hg19					enhancer	enh				GCTCAAGGCCGGGATGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				0.092643651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4401	chr2	75185824	75185846	74958697	74958719	76596	hg19					enhancer	enh				GCAGGAAGCGGGACGCCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.32452692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4402	chr2	75185828	75185849	74958701	74958722	76597	hg19					enhancer	enh				GAAGCGGGACGCCCCGAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	direct	Highly Significant	NA				0.412602152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4403	chr2	75185833	75185853	74958706	74958726	76598	hg19					enhancer	enh				GGGACGCCCCGAGAGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.424764868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4404	chr2	75185842	75185862	74958715	74958735	76599	hg19					enhancer	enh				GCAGGTCCCTCCTCCTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.113773927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4405	chr2	75185860	75185880	74958733	74958753	76600	hg19					enhancer	enh				GAGGCCGCTGCCTCCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLE4	indirect	Non Significant	NA				-0.071862925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-92264	chr2	84686240	84686262	84459116	84459138	76601	hg19	N/A	N/A	N/A	Enhatls98851	enhancer	enh				GTCCGGCGGGGCCAATAACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.603342263	SUCLG1	chr2	84423527	84459280	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4190
enhrx-92264	chr2	84686245	84686267	84459121	84459143	76602	hg19	N/A	N/A	N/A	Enhatls98851	enhancer	enh				GCCCGCGGGTTATTGGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				0.095513553	SUCLG1	chr2	84423527	84459280	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4190
enhrx-92264	chr2	84686250	84686270	84459126	84459146	76603	hg19	N/A	N/A	N/A	Enhatls98851	enhancer	enh				GCCAATAACCCGCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.458664023	SUCLG1	chr2	84423527	84459280	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4190
enhrx-92264	chr2	84686262	84686283	84459138	84459159	76604	hg19	N/A	N/A	N/A	Enhatls98851	enhancer	enh				GTACTGTCTTCCTGGCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.526472997	SUCLG1	chr2	84423527	84459280	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4190
enhrx-92264	chr2	84686275	84686295	84459151	84459171	76605	hg19	N/A	N/A	N/A	Enhatls98851	enhancer	enh				GACAGTACTGGCTGGACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.429708747	SUCLG1	chr2	84423527	84459280	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4190
enhrx-lit4406	chr2	84686300	84686320	84459176	84459196	76606	hg19					enhancer	enh				GAAGCTGCGCGACAGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.3310235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4407	chr2	84686324	84686344	84459200	84459220	76607	hg19					enhancer	enh				GGCGGCGAGGCCGCTGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.23048445									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4408	chr2	84686332	84686353	84459208	84459229	76608	hg19					enhancer	enh				GGCCGCTGCTGCCGGAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				0.024180317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4409	chr2	84686333	84686353	84459209	84459229	76609	hg19					enhancer	enh				GCCGCTGCTGCCGGAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.037309782									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4410	chr2	84686346	84686368	84459222	84459244	76610	hg19					enhancer	enh				GAGACCATGGTAGCGATGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.088610383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4411	chr2	84686348	84686368	84459224	84459244	76611	hg19					enhancer	enh				GACCATGGTAGCGATGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.132838571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4412	chr2	84686353	84686375	84459229	84459251	76612	hg19					enhancer	enh				GCTGCCGCTGACATCGCTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.019501566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4413	chr2	84686354	84686374	84459230	84459250	76613	hg19					enhancer	enh				GGTAGCGATGTCAGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.281272234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4414	chr2	84686358	84686379	84459234	84459255	76614	hg19					enhancer	enh				GCGATGTCAGCGGCAGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.206765769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4415	chr2	84686360	84686380	84459236	84459256	76615	hg19					enhancer	enh				GATGTCAGCGGCAGCGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.195721651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4416	chr2	84686388	84686410	84459264	84459286	76616	hg19					enhancer	enh				GTCATACGCCAATGACACTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.279281947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4417	chr2	84686395	84686417	84459271	84459293	76617	hg19					enhancer	enh				GCCAATGACACTCCCAGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	direct	Highly Significant	NA				0.86145981									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4418	chr2	84686494	84686514	84459370	84459390	76618	hg19					enhancer	enh				GAGGATTCTTCACGAAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SUCLG1	indirect	Non Significant	NA				-0.295676349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4419	chr2	85829600	85829621	85602477	85602498	76619	hg19					enhancer	enh				GTCCCCGCGCCCAGGCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	direct	Highly Significant	NA				0.330338974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4420	chr2	85829657	85829679	85602534	85602556	76620	hg19					enhancer	enh				GACTCTCGCGTCCCGGGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.017881122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4421	chr2	85829683	85829703	85602560	85602580	76621	hg19					enhancer	enh				GGTGATTCCTGGAAGCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.420288098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4422	chr2	85829714	85829734	85602591	85602611	76622	hg19					enhancer	enh				GAGCCCAGTACGCACCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.302312394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4423	chr2	85829721	85829742	85602598	85602619	76623	hg19					enhancer	enh				GCGCTCCGGGGAGGTGCGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	direct	Highly Significant	NA				0.768985302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4424	chr2	85829771	85829791	85602648	85602668	76624	hg19					enhancer	enh				GCTAGAGTCGGCGCCACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.49667766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4425	chr2	85829772	85829794	85602649	85602671	76625	hg19					enhancer	enh				GCAGCTAGAGTCGGCGCCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	direct	Highly Significant	NA				0.23286792									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4426	chr2	85829773	85829794	85602650	85602671	76626	hg19					enhancer	enh				GCAGCTAGAGTCGGCGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.134356099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4427	chr2	85829779	85829800	85602656	85602677	76627	hg19					enhancer	enh				GCCGACTCTAGCTGCGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.487852785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4428	chr2	85829794	85829815	85602671	85602692	76628	hg19					enhancer	enh				GGCCCTCGGAGCAGCCCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				0.033793147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4429	chr2	85829795	85829815	85602672	85602692	76629	hg19					enhancer	enh				GCCCTCGGAGCAGCCCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.186133786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4430	chr2	85829802	85829824	85602679	85602701	76630	hg19					enhancer	enh				GAGCAGCCCTGAAAGGTTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.320160166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4431	chr2	85829804	85829824	85602681	85602701	76631	hg19					enhancer	enh				GCAGCCCTGAAAGGTTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.866878147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4432	chr2	85829812	85829832	85602689	85602709	76632	hg19					enhancer	enh				GAAAGGTTTAAAGGGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.339015832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4433	chr2	85829874	85829894	85602751	85602771	76633	hg19					enhancer	enh				GCGCGGACTCCACGTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.465467261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4434	chr2	85829913	85829935	85602790	85602812	76634	hg19					enhancer	enh				GTTGTAGTCTCGGGCAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	direct	Highly Significant	NA				0.475383034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4435	chr2	85829919	85829939	85602796	85602816	76635	hg19					enhancer	enh				GGGAGTTGTAGTCTCGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM150A	indirect	Non Significant	NA				-0.091362379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4436	chr2	86332808	86332828	86105685	86105705	76636	hg19					enhancer	enh				GCTCAAGTAAGGAGTTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-0.723928425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4437	chr2	86332813	86332833	86105690	86105710	76637	hg19					enhancer	enh				GAAGAGCTCAAGTAAGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-1.11988102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4438	chr2	86332852	86332874	86105729	86105751	76638	hg19					enhancer	enh				GAAATGCCCTGCAGCCGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.510907648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4439	chr2	86332875	86332897	86105752	86105774	76639	hg19					enhancer	enh				GTTGATCTCCAAGAACATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-0.349713696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4440	chr2	86332905	86332925	86105782	86105802	76640	hg19					enhancer	enh				GTCGGAATTCAAAACGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				0.064170443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4441	chr2	86332905	86332927	86105782	86105804	76641	hg19					enhancer	enh				GTGTCGGAATTCAAAACGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.371022983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4442	chr2	86332950	86332972	86105827	86105849	76642	hg19					enhancer	enh				GGTTGAATTAAGAATAGTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-1.719838089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4443	chr2	86332950	86332971	86105827	86105848	76643	hg19					enhancer	enh				GTTGAATTAAGAATAGTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-1.723589656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4444	chr2	86332953	86332974	86105830	86105851	76644	hg19					enhancer	enh				GAGGTTGAATTAAGAATAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-2.909201383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4445	chr2	86332980	86333001	86105857	86105878	76645	hg19					enhancer	enh				GTTGAATCGCGTGGTGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-0.98642105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4446	chr2	86332981	86333001	86105858	86105878	76646	hg19					enhancer	enh				GTTGAATCGCGTGGTGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-0.617545712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4447	chr2	86332990	86333011	86105867	86105888	76647	hg19					enhancer	enh				GCAAGCGCACGTTGAATCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.462190307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4448	chr2	86332993	86333014	86105870	86105891	76648	hg19					enhancer	enh				GATTCAACGTGCGCTTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.393647311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4449	chr2	86333005	86333027	86105882	86105904	76649	hg19					enhancer	enh				GCTTGCGCGCGGAAGCGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.479638962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4450	chr2	86333021	86333043	86105898	86105920	76650	hg19					enhancer	enh				GGTCGCAGGAACGACATTTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				-0.842808104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4451	chr2	86333022	86333043	86105899	86105920	76651	hg19					enhancer	enh				GTCGCAGGAACGACATTTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				0.139808303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4452	chr2	86333044	86333064	86105921	86105941	76652	hg19					enhancer	enh				GGATGAGATCACTTCTACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	indirect	Non Significant	NA				0.080741512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4453	chr2	86333155	86333176	86106032	86106053	76653	hg19					enhancer	enh				GAAAATTCCTCCGAGGCAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.190983263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4454	chr2	86333168	86333190	86106045	86106067	76654	hg19					enhancer	enh				GCTCTATACACCCGATTTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	POLR1A	direct	Highly Significant	NA				0.405214504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4455	chr2	86333310	86333331	86106187	86106208	76655	hg19					enhancer	enh				GCCCCACCTTCCTGAAGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.291466218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4456	chr2	86333314	86333335	86106191	86106212	76656	hg19					enhancer	enh				GCCTCGACCTTCAGGAAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.246634062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4457	chr2	86333315	86333335	86106192	86106212	76657	hg19					enhancer	enh				GCCTCGACCTTCAGGAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-0.555605055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4458	chr2	86333316	86333337	86106193	86106214	76658	hg19					enhancer	enh				GTGCCTCGACCTTCAGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.19637711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4459	chr2	86333319	86333339	86106196	86106216	76659	hg19					enhancer	enh				GCGTGCCTCGACCTTCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-0.426448582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4460	chr2	86333350	86333371	86106227	86106248	76660	hg19					enhancer	enh				GCTCTGCAGAGAAATCAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	direct	Highly Significant	NA				0.480702923									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4461	chr2	86333372	86333394	86106249	86106271	76661	hg19					enhancer	enh				GGCGGTTGTATCTGCTGTTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-0.02944005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4462	chr2	86333373	86333394	86106250	86106271	76662	hg19					enhancer	enh				GCGGTTGTATCTGCTGTTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				0.148307711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4463	chr2	86333392	86333412	86106269	86106289	76663	hg19					enhancer	enh				GCTGGCTGGGCCTCCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				0.194996516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4464	chr2	86333396	86333417	86106273	86106294	76664	hg19					enhancer	enh				GCTGGGCCTCCGCAGCAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-2.471876303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4465	chr2	86333405	86333425	86106282	86106302	76665	hg19					enhancer	enh				GCTGGCCAAGCCTGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-2.351641112									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4466	chr2	86333405	86333426	86106282	86106303	76666	hg19					enhancer	enh				GGCTGGCCAAGCCTGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-2.27839785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4467	chr2	86333410	86333432	86106287	86106309	76667	hg19					enhancer	enh				GCAGGCTTGGCCAGCCGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-3.439554484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4468	chr2	86333414	86333436	86106291	86106313	76668	hg19					enhancer	enh				GCTTGGCCAGCCGCTGACGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.416567518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4469	chr2	86333419	86333440	86106296	86106317	76669	hg19					enhancer	enh				GCCAGCCGCTGACGGGTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				0.145830004									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4470	chr2	86333419	86333439	86106296	86106316	76670	hg19					enhancer	enh				GCCAGCCGCTGACGGGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.485589153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4471	chr2	86333438	86333458	86106315	86106335	76671	hg19					enhancer	enh				GCGGGCGGGTTTGTGTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-1.019070359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4472	chr2	86333489	86333509	86106366	86106386	76672	hg19					enhancer	enh				GGTATCCGCGAAGAAGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTCD3	indirect	Non Significant	NA				-0.149503433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4473	chr2	86668482	86668503	86441359	86441380	76673	hg19					enhancer	enh				GCTCTTGAACCAAGTCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				0.072178788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4474	chr2	86668488	86668509	86441365	86441386	76674	hg19					enhancer	enh				GAACCAAGTCAGCGCTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.533824028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4475	chr2	86668495	86668517	86441372	86441394	76675	hg19					enhancer	enh				GTCAGCGCTGGAGTCGGCTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.419594209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4476	chr2	86668501	86668521	86441378	86441398	76676	hg19					enhancer	enh				GCTGGAGTCGGCTAGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				0.032414763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4477	chr2	86668505	86668527	86441382	86441404	76677	hg19					enhancer	enh				GAGTCGGCTAGGCGGCTGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.851534278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4478	chr2	86668507	86668527	86441384	86441404	76678	hg19					enhancer	enh				GTCGGCTAGGCGGCTGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.151616999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4479	chr2	86668510	86668530	86441387	86441407	76679	hg19					enhancer	enh				GGCTAGGCGGCTGGAAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.281799205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4480	chr2	86668518	86668540	86441395	86441417	76680	hg19					enhancer	enh				GGCTGGAAACGGCGGCTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.096554626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4481	chr2	86668519	86668540	86441396	86441417	76681	hg19					enhancer	enh				GCTGGAAACGGCGGCTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	direct	Highly Significant	NA				0.46359729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4482	chr2	86668528	86668550	86441405	86441427	76682	hg19					enhancer	enh				GGCGGCTGCCGCCGGTGACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.548101469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4483	chr2	86668529	86668550	86441406	86441427	76683	hg19					enhancer	enh				GCGGCTGCCGCCGGTGACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.392710667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4484	chr2	86668535	86668557	86441412	86441434	76684	hg19					enhancer	enh				GCCGCCGGTGACTCAGGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.508413627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4485	chr2	86668542	86668564	86441419	86441441	76685	hg19					enhancer	enh				GCCTCCCGCCTCCCTGAGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.338975392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4486	chr2	86668565	86668585	86441442	86441462	76686	hg19					enhancer	enh				GGGTAAGAGCGCCGCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	direct	Highly Significant	NA				0.749255317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4487	chr2	86668571	86668591	86441448	86441468	76687	hg19					enhancer	enh				GAGCGCCGCGGCCTCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KDM3A	indirect	Non Significant	NA				-0.290403525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4488	chr2	86850764	86850784	86623641	86623661	76688	hg19					enhancer	enh				GCAGATGGAATCGGTCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				0.169368069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4489	chr2	86850847	86850869	86623724	86623746	76689	hg19					enhancer	enh				GCCACTCAGCGCCCGTCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.496509356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4490	chr2	86850861	86850883	86623738	86623760	76690	hg19					enhancer	enh				GCACTGCCCATCCGAGCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.211274014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4491	chr2	86850862	86850883	86623739	86623760	76691	hg19					enhancer	enh				GCACTGCCCATCCGAGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-0.428513704									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4492	chr2	86850867	86850888	86623744	86623765	76692	hg19					enhancer	enh				GACCGGCACTGCCCATCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-1.156843203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4493	chr2	86850919	86850940	86623796	86623817	76693	hg19					enhancer	enh				GGGTACGGCCGCGGTCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				0.172739945									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4494	chr2	86850919	86850939	86623796	86623816	76694	hg19					enhancer	enh				GGTACGGCCGCGGTCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.206258152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4495	chr2	86850935	86850956	86623812	86623833	76695	hg19					enhancer	enh				GATACACGGTTGTGGAGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.303176826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4496	chr2	86850940	86850962	86623817	86623839	76696	hg19					enhancer	enh				GCCGCTGATACACGGTTGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-0.112689201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4497	chr2	86850941	86850962	86623818	86623839	76697	hg19					enhancer	enh				GCCGCTGATACACGGTTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.318347916									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4498	chr2	86850950	86850972	86623827	86623849	76698	hg19					enhancer	enh				GGCCGCGGCCGCCGCTGATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				0.086914279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4499	chr2	86850950	86850971	86623827	86623848	76699	hg19					enhancer	enh				GCCGCGGCCGCCGCTGATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-0.011532356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4500	chr2	86850967	86850988	86623844	86623865	76700	hg19					enhancer	enh				GTTATGTCTCGGCTCCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-0.526033129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4501	chr2	86851076	86851096	86623953	86623973	76701	hg19					enhancer	enh				GCTACCGGACTACCGAACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	indirect	Non Significant	NA				-0.390322944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4502	chr2	86851083	86851104	86623960	86623981	76702	hg19					enhancer	enh				GACTACCGAACGAGGGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.676683091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4503	chr2	86851137	86851158	86624014	86624035	76703	hg19					enhancer	enh				GCAACTTTCGGCACCGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNF103	direct	Highly Significant	NA				0.421227546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4504	chr2	86947260	86947281	86720137	86720158	76704	hg19					enhancer	enh				GTGTGGGCCGTACCACACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.757364137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4505	chr2	86947268	86947289	86720145	86720166	76705	hg19					enhancer	enh				GTACGGCCCACACCATTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				0.158510618									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4506	chr2	86947278	86947298	86720155	86720175	76706	hg19					enhancer	enh				GCGCCGCCACTCTAATGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.698577097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4507	chr2	86947377	86947398	86720254	86720275	76707	hg19					enhancer	enh				GCGCCGCCTCCTTTCCTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				0.168633035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4508	chr2	86947420	86947440	86720297	86720317	76708	hg19					enhancer	enh				GCACCAAGCGCCGCCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				0.095881532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4509	chr2	86947422	86947444	86720299	86720321	76709	hg19					enhancer	enh				GGCGGCACCAAGCGCCGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.277446483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4510	chr2	86947422	86947443	86720299	86720320	76710	hg19					enhancer	enh				GCGGCACCAAGCGCCGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.170452374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4511	chr2	86947425	86947445	86720302	86720322	76711	hg19					enhancer	enh				GGCGGCGCTTGGTGCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.152444617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4512	chr2	86947533	86947553	86720410	86720430	76712	hg19					enhancer	enh				GCACTCGGCTCCGCGTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.26966433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4513	chr2	86947542	86947563	86720419	86720440	76713	hg19					enhancer	enh				GAGCCGAGTGCAGCGAGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-0.960789805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4514	chr2	86947566	86947586	86720443	86720463	76714	hg19					enhancer	enh				GAGCAGCGGCGACTCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RMND5A	indirect	Non Significant	NA				-1.051596035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4515	chr2	88355186	88355208	88055667	88055689	76715	hg19					enhancer	enh				GCCCCGCCAACGCCGCCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	direct	Highly Significant	NA				0.612952065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4516	chr2	88355200	88355220	88055681	88055701	76716	hg19					enhancer	enh				GCCAGCCAGGGGATAAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	direct	Highly Significant	NA				0.751232606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4517	chr2	88355220	88355241	88055701	88055722	76717	hg19					enhancer	enh				GCCTCTCCGCCACCTCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.407774699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4518	chr2	88355266	88355286	88055747	88055767	76718	hg19					enhancer	enh				GCCTCCGCCGCCGAGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.129000796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4519	chr2	88355302	88355323	88055783	88055804	76719	hg19					enhancer	enh				GCGGAGACCCGGCTTCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.115570158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4520	chr2	88355302	88355322	88055783	88055803	76720	hg19					enhancer	enh				GCGGAGACCCGGCTTCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.304399548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4521	chr2	88355312	88355333	88055793	88055814	76721	hg19					enhancer	enh				GCGACTTCCCCTCAGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.202981485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4522	chr2	88355322	88355342	88055803	88055823	76722	hg19					enhancer	enh				GGGGAAGTCGCCGCCACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	direct	Highly Significant	NA				0.350833662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4523	chr2	88355331	88355353	88055812	88055834	76723	hg19					enhancer	enh				GCCGCCACTACCGGCTTATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.093151364									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4524	chr2	88355338	88355358	88055819	88055839	76724	hg19					enhancer	enh				GTCCAGTCATAAGCCGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				0.041777952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4525	chr2	88355380	88355400	88055861	88055881	76725	hg19					enhancer	enh				GACGCGCTACTGCGCTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KRCC1	indirect	Non Significant	NA				-0.444208055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4526	chr2	95787480	95787501	95121735	95121756	76726	hg19					enhancer	enh				GCCGTCCCGCTACACAGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-2.506214886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4527	chr2	95787480	95787500	95121735	95121755	76727	hg19					enhancer	enh				GCCGTCCCGCTACACAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-3.541611053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4528	chr2	95787489	95787511	95121744	95121766	76728	hg19					enhancer	enh				GCTGCCTCCCCGTGCTGTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.508304203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4529	chr2	95787505	95787526	95121760	95121781	76729	hg19					enhancer	enh				GGCAGCCCACAGCGCGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.770837818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4530	chr2	95787506	95787526	95121761	95121781	76730	hg19					enhancer	enh				GCAGCCCACAGCGCGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.479890448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4531	chr2	95787516	95787538	95121771	95121793	76731	hg19					enhancer	enh				GCGCGCACCGCGGTCGCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-0.486551301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4532	chr2	95787518	95787538	95121773	95121793	76732	hg19					enhancer	enh				GCGCACCGCGGTCGCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.643365147									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4533	chr2	95787526	95787546	95121781	95121801	76733	hg19					enhancer	enh				GGACTCCAGCATGGCGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.913420424									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4534	chr2	95787535	95787555	95121790	95121810	76734	hg19					enhancer	enh				GCGCGGCTCGGACTCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-1.644415676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4535	chr2	95787557	95787577	95121812	95121832	76735	hg19					enhancer	enh				GCTGCCCTGGGCGGAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	direct	Highly Significant	NA				0.26940546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4536	chr2	95787563	95787583	95121818	95121838	76736	hg19					enhancer	enh				GGCAAGGCTGCCCTGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MRPS5	indirect	Non Significant	NA				-2.568613595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4537	chr2	95831264	95831285	95165519	95165540	76737	hg19					enhancer	enh				GACGGCGCTCCCATCGGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.253947272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4538	chr2	95831276	95831296	95165531	95165551	76738	hg19					enhancer	enh				GCGTCCCTCCAGTATCCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	direct	Highly Significant	NA				0.210875504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4539	chr2	95831286	95831308	95165541	95165563	76739	hg19					enhancer	enh				GGAGGGACGCGACACTAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.647973261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4540	chr2	95831287	95831308	95165542	95165563	76740	hg19					enhancer	enh				GAGGGACGCGACACTAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.875969435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4541	chr2	95831366	95831387	95165621	95165642	76741	hg19					enhancer	enh				GGCAGCGCTGTCGCCTTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	direct	Highly Significant	NA				0.28366117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4542	chr2	95831366	95831386	95165621	95165641	76742	hg19					enhancer	enh				GCAGCGCTGTCGCCTTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	direct	Highly Significant	NA				0.479203321									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4543	chr2	95831367	95831387	95165622	95165642	76743	hg19					enhancer	enh				GGCAGCGCTGTCGCCTTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.748013205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4544	chr2	95831388	95831409	95165643	95165664	76744	hg19					enhancer	enh				GTGGCTGAACAGGATCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.360867735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4545	chr2	95831399	95831420	95165654	95165675	76745	hg19					enhancer	enh				GCCGGCTTCCCGTGGCTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				0.194755359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4546	chr2	95831408	95831428	95165663	95165683	76746	hg19					enhancer	enh				GTGCAAACGCCGGCTTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.25199458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4547	chr2	95831408	95831430	95165663	95165685	76747	hg19					enhancer	enh				GTGTGCAAACGCCGGCTTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	direct	Highly Significant	NA				0.562439882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4548	chr2	95831418	95831440	95165673	95165695	76748	hg19					enhancer	enh				GTCCGAAAATGTGTGCAAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				0.106100371									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4549	chr2	95831437	95831457	95165692	95165712	76749	hg19					enhancer	enh				GACGTCATATTAAAGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.045028512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4550	chr2	95831474	95831494	95165729	95165749	76750	hg19					enhancer	enh				GGGAGATGAAGTCCTTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.207502377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4551	chr2	95831500	95831522	95165755	95165777	76751	hg19					enhancer	enh				GACTGCGCTCCCAATCAATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.230926797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4552	chr2	95831527	95831547	95165782	95165802	76752	hg19					enhancer	enh				GACCCTGTGCGCAGGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.049321067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4553	chr2	95831533	95831554	95165788	95165809	76753	hg19					enhancer	enh				GAAACCAACGCGCCTGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.419841758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4554	chr2	95831545	95831565	95165800	95165820	76754	hg19					enhancer	enh				GTTGGTTTCCCGACCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				0.172319691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4555	chr2	95831556	95831578	95165811	95165833	76755	hg19					enhancer	enh				GAAGACGGCGCCTCTTCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	indirect	Non Significant	NA				-0.233794031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4556	chr2	95831573	95831593	95165828	95165848	76756	hg19					enhancer	enh				GTGCTCGGGACCCGGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZNF514	direct	Highly Significant	NA				0.580142439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4557	chr2	96068403	96068425	95402655	95402677	76757	hg19					enhancer	enh				GCCACTAGCAGGGCGCCAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-1.820004268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4558	chr2	96068416	96068438	95402668	95402690	76758	hg19					enhancer	enh				GTCACAGGCAATGGCCACTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.234502634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4559	chr2	96068422	96068443	95402674	95402695	76759	hg19					enhancer	enh				GGCCATTGCCTGTGACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.768357567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4560	chr2	96068423	96068443	95402675	95402695	76760	hg19					enhancer	enh				GCCATTGCCTGTGACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.184336678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4561	chr2	96068427	96068449	95402679	95402701	76761	hg19					enhancer	enh				GATCCTGTGACGTCACAGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	direct	Highly Significant	NA				0.535658534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4562	chr2	96068433	96068454	95402685	95402706	76762	hg19					enhancer	enh				GGCGCGATCCTGTGACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.737438475									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4563	chr2	96068433	96068453	95402685	95402705	76763	hg19					enhancer	enh				GCGCGATCCTGTGACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	direct	Highly Significant	NA				0.230583448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4564	chr2	96068455	96068475	95402707	95402727	76764	hg19					enhancer	enh				GGATCACCCGAGAGAAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				0.002484966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4565	chr2	96068456	96068478	95402708	95402730	76765	hg19					enhancer	enh				GCCGGATCACCCGAGAGAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.38733008									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4566	chr2	96068467	96068489	95402719	95402741	76766	hg19					enhancer	enh				GGTGATCCGGCCGAGTGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	direct	Highly Significant	NA				0.364125921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4567	chr2	96068468	96068489	95402720	95402741	76767	hg19					enhancer	enh				GTGATCCGGCCGAGTGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				0.153785245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4568	chr2	96068476	96068497	95402728	95402749	76768	hg19					enhancer	enh				GCTAACCCAGGGCCACTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				0.079952707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4569	chr2	96068480	96068500	95402732	95402752	76769	hg19					enhancer	enh				GCTGCTAACCCAGGGCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.001999029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4570	chr2	96068489	96068511	95402741	95402763	76770	hg19					enhancer	enh				GAAATGCAGCAGCTGCTAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.511718935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4571	chr2	96068491	96068513	95402743	95402765	76771	hg19					enhancer	enh				GTTAGCAGCTGCTGCATTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	direct	Highly Significant	NA				0.334905957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4572	chr2	96068495	96068517	95402747	95402769	76772	hg19					enhancer	enh				GCAGCTGCTGCATTTCCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.291947673									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4573	chr2	96068501	96068523	95402753	95402775	76773	hg19					enhancer	enh				GCTGCATTTCCCCGGCTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	direct	Highly Significant	NA				0.254212695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4574	chr2	96068515	96068537	95402767	95402789	76774	hg19					enhancer	enh				GCCACCAGTGACCGCAGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.208911663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4575	chr2	96068524	96068544	95402776	95402796	76775	hg19					enhancer	enh				GGTCACTGGTGGCAGTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				-0.400548116									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4576	chr2	96068573	96068594	95402825	95402846	76776	hg19					enhancer	enh				GCTGTAGGGTTAGAGCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAHD2A	indirect	Non Significant	NA				0.171565271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4577	chr2	96931831	96931853	96266093	96266115	76777	hg19					enhancer	enh				GCCTCGAACTACCAGTCCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.322485771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4578	chr2	96931932	96931953	96266194	96266215	76778	hg19					enhancer	enh				GTTGAGTTTCCGGGGCGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	direct	Highly Significant	NA				0.209772708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4579	chr2	96931943	96931964	96266205	96266226	76779	hg19					enhancer	enh				GGGGCGACCCAGGTCCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.534949455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4580	chr2	96931944	96931965	96266206	96266227	76780	hg19					enhancer	enh				GCCGGAGGACCTGGGTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.288225212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4581	chr2	96931948	96931970	96266210	96266232	76781	hg19					enhancer	enh				GACCCAGGTCCTCCGGCGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.695153093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4582	chr2	96931960	96931980	96266222	96266242	76782	hg19					enhancer	enh				GAGGCTCCCGCTTCCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	direct	Highly Significant	NA				0.202077507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4583	chr2	96931963	96931984	96266225	96266246	76783	hg19					enhancer	enh				GACAGAGGCTCCCGCTTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				0.11424533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4584	chr2	96931969	96931989	96266231	96266251	76784	hg19					enhancer	enh				GCGGGAGCCTCTGTCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.062530174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4585	chr2	96931975	96931997	96266237	96266259	76785	hg19					enhancer	enh				GCCTCTGTCGGCCGCGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				0.01755258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4586	chr2	96931981	96932002	96266243	96266264	76786	hg19					enhancer	enh				GTCGGCCGCGGAAGCCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.410923485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4587	chr2	96931981	96932003	96266243	96266265	76787	hg19					enhancer	enh				GTCGGCCGCGGAAGCCTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.699702323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4588	chr2	96931998	96932018	96266260	96266280	76788	hg19					enhancer	enh				GTCTGCGTACCGCCCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.04767459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4589	chr2	96932003	96932023	96266265	96266285	76789	hg19					enhancer	enh				GGGCGGTACGCAGACGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.514247602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4590	chr2	96932025	96932047	96266287	96266309	76790	hg19					enhancer	enh				GTGAGACCCGCTGTCTGCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	direct	Highly Significant	NA				0.256550686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4591	chr2	96932027	96932047	96266289	96266309	76791	hg19					enhancer	enh				GAGACCCGCTGTCTGCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				0.03674676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4592	chr2	96932034	96932054	96266296	96266316	76792	hg19					enhancer	enh				GAGTCCGCTGAGCAGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.225833279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4593	chr2	96932075	96932097	96266337	96266359	76793	hg19					enhancer	enh				GTCCTTCATGTCGGCCCGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				0.066299367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4594	chr2	96932081	96932101	96266343	96266363	76794	hg19					enhancer	enh				GGCCGACATGAAGGACTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	indirect	Non Significant	NA				-0.571280556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4595	chr2	96932117	96932138	96266379	96266400	76795	hg19					enhancer	enh				GAGTCCGGGTGCGCCGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CIAO1	direct	Highly Significant	NA				0.354076256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4596	chr2	96971132	96971153	96305394	96305415	76796	hg19					enhancer	enh				GTCTGCAATACGAGTACAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-2.200700123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4597	chr2	96971136	96971156	96305398	96305418	76797	hg19					enhancer	enh				GTACTCGTATTGCAGACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-2.954076779									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4598	chr2	96971160	96971180	96305422	96305442	76798	hg19					enhancer	enh				GGTTACATCCGCCATGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.353690108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4599	chr2	96971170	96971191	96305432	96305453	76799	hg19					enhancer	enh				GCCATGGCCGCGGCTGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-3.806236325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4600	chr2	96971174	96971195	96305436	96305457	76800	hg19					enhancer	enh				GCCTCCGAGCAGCCGCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-1.274667237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4601	chr2	96971180	96971202	96305442	96305464	76801	hg19					enhancer	enh				GTCTGAAGCCTCCGAGCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.733699137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4602	chr2	96971215	96971236	96305477	96305498	76802	hg19					enhancer	enh				GGCCGTTTGCAGCTTGCGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-1.929811859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4603	chr2	96971215	96971235	96305477	96305497	76803	hg19					enhancer	enh				GCCGTTTGCAGCTTGCGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-2.842806171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4604	chr2	96971216	96971236	96305478	96305498	76804	hg19					enhancer	enh				GGCCGTTTGCAGCTTGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.734867846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4605	chr2	96971239	96971259	96305501	96305521	76805	hg19					enhancer	enh				GATCTCTGCTCCCGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-1.455708876									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4606	chr2	96971261	96971283	96305523	96305545	76806	hg19					enhancer	enh				GAACGACGCAGGAAAGACGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-1.561528698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4607	chr2	96971265	96971285	96305527	96305547	76807	hg19					enhancer	enh				GACGCAGGAAAGACGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-3.248721067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4608	chr2	96971320	96971340	96305582	96305602	76808	hg19					enhancer	enh				GGTCGCGCCCCAGAAGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.003106593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4609	chr2	96971367	96971388	96305629	96305650	76809	hg19					enhancer	enh				GAAAGCCGCGCGCACACGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.481518763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4610	chr2	96971372	96971393	96305634	96305655	76810	hg19					enhancer	enh				GTGCGGAAAGCCGCGCGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.816668129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4611	chr2	96971396	96971416	96305658	96305678	76811	hg19					enhancer	enh				GCCCACATATCCCGCTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.230033753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4612	chr2	96971405	96971426	96305667	96305688	76812	hg19					enhancer	enh				GATATGTGGGCCTGGTGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	direct	Highly Significant	NA				0.293134221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4613	chr2	96971418	96971440	96305680	96305702	76813	hg19					enhancer	enh				GATTCGGGGACCCAGACGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SNRNP200	indirect	Non Significant	NA				-0.051300352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4614	chr2	96991018	96991038	96325280	96325300	76814	hg19					enhancer	enh				GGGAGGAGCTTGTACTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.053449906									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4615	chr2	96991022	96991042	96325284	96325304	76815	hg19					enhancer	enh				GGAGCTTGTACTGGGTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				0.086048059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4616	chr2	96991023	96991043	96325285	96325305	76816	hg19					enhancer	enh				GAGCTTGTACTGGGTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.030818583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4617	chr2	96991054	96991076	96325316	96325338	76817	hg19					enhancer	enh				GCCGCAGCCGCTCCCGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.074847011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4618	chr2	96991055	96991076	96325317	96325338	76818	hg19					enhancer	enh				GCCGCAGCCGCTCCCGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	direct	Highly Significant	NA				0.253786121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4619	chr2	96991084	96991105	96325346	96325367	76819	hg19					enhancer	enh				GCCCTCGGAGCCGCGTGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.003280726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4620	chr2	96991084	96991104	96325346	96325366	76820	hg19					enhancer	enh				GCCCTCGGAGCCGCGTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	direct	Highly Significant	NA				0.43882652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4621	chr2	96991120	96991141	96325382	96325403	76821	hg19					enhancer	enh				GAACGTCTGGCTGAGCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.264008284									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4622	chr2	96991137	96991158	96325399	96325420	76822	hg19					enhancer	enh				GTTCAGACGCTCGGACAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				0.132707344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4623	chr2	96991150	96991171	96325412	96325433	76823	hg19					enhancer	enh				GACAAGCATGGTCTATAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-1.013541885									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4624	chr2	96991180	96991201	96325442	96325463	76824	hg19					enhancer	enh				GAGCAGGGCCACTCCCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.844792232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4625	chr2	96991198	96991218	96325460	96325480	76825	hg19					enhancer	enh				GGGCGGCCCCAGCGATGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	indirect	Non Significant	NA				-0.14424969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4626	chr2	96991208	96991228	96325470	96325490	76826	hg19					enhancer	enh				GGGGCGTCCGGTTCATCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITPRIPL1	direct	Highly Significant	NA				0.234888424									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-93058	chr2	97560679	97560699	96894942	96894962	76827	hg19	N/A	enh18736	N/A	Enhatls99670	enhancer	enh				GTGGGCCCACAGATGCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.270253632	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560715	97560735	96894978	96894998	76828	hg19	N/A	enh18736	N/A	Enhatls99670	enhancer	enh				GAAGAGTTAAACCAAAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				0.114407533	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560749	97560770	96895012	96895033	76829	hg19	N/A	enh18736	N/A	Enhatls99670	enhancer	enh				GAACACCATGAAGAGAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.108315853	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560770	97560792	96895033	96895055	76830	hg19	N/A	enh18736	N/A	Enhatls99670	enhancer	enh				GGACTGTTGGGGACTTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.21476753	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560770	97560792	96895033	96895055	76831	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGACTGTTGGGGACTTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.21476753	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560770	97560791	96895033	96895054	76832	hg19	N/A	enh18736	N/A	Enhatls99670	enhancer	enh				GACTGTTGGGGACTTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.364223897	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560770	97560791	96895033	96895054	76833	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GACTGTTGGGGACTTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.364223897	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560799	97560819	96895062	96895082	76834	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GATGATGGTGGTCTTGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.040310404	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560814	97560835	96895077	96895098	76835	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGCCAGGCGGAATGAAGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.264196521	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560814	97560834	96895077	96895097	76836	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GCCAGGCGGAATGAAGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.278844942	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560828	97560848	96895091	96895111	76837	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGCTGAAGACACAGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.050176203	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560828	97560849	96895091	96895112	76838	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGGCTGAAGACACAGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.608258673	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560828	97560850	96895091	96895113	76839	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGGGCTGAAGACACAGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.040461557	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560836	97560858	96895099	96895121	76840	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGAAGGCAGGGGCTGAAGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.06839834	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560836	97560857	96895099	96895120	76841	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GAAGGCAGGGGCTGAAGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-0.9711497	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560864	97560884	96895127	96895147	76842	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GGAAGGAAAAGAGCGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				-3.248598873	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560927	97560947	96895190	96895210	76843	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GAGCTTCTACAGAAAAGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				0.010636122	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97560961	97560982	96895224	96895245	76844	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GAAATGGTATTATGATTAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	indirect	Non Significant	NA				0.148613777	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-93058	chr2	97561028	97561049	96895291	96895312	76845	hg19	N/A	enh18736	N/A	N/A	enhancer	enh				GAGACAGAGAAAACTGAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM178B	direct	Highly Significant	NA				0.801454377	FAM178B	chr2	96875881	96986580	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	4984
enhrx-lit4627	chr2	98612292	98612312	97995829	97995849	76846	hg19					enhancer	enh				GTGAGCGAGAGTGTCAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.569072824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4628	chr2	98612302	98612323	97995839	97995860	76847	hg19					enhancer	enh				GTGTCAGTCACGGTCTTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	direct	Highly Significant	NA				0.479056366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4629	chr2	98612324	98612344	97995861	97995881	76848	hg19					enhancer	enh				GGGCATCGCCTACAAGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				0.081235637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4630	chr2	98612324	98612345	97995861	97995882	76849	hg19					enhancer	enh				GACTGCTTGTAGGCGATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.100701115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4631	chr2	98612367	98612387	97995904	97995924	76850	hg19					enhancer	enh				GGCGCGGCGGGCGGCCATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-1.022684732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4632	chr2	98612372	98612394	97995909	97995931	76851	hg19					enhancer	enh				GGCGGGCGGCCATACTGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.213547102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4633	chr2	98612373	98612394	97995910	97995931	76852	hg19					enhancer	enh				GCGGGCGGCCATACTGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.088182134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4634	chr2	98612377	98612399	97995914	97995936	76853	hg19					enhancer	enh				GCGGCCATACTGGAAACGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.156594029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4635	chr2	98612379	98612399	97995916	97995936	76854	hg19					enhancer	enh				GGCCATACTGGAAACGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	direct	Highly Significant	NA				0.410833686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4636	chr2	98612384	98612404	97995921	97995941	76855	hg19					enhancer	enh				GGCCGTGCCCGTTTCCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.058675271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4637	chr2	98612384	98612405	97995921	97995942	76856	hg19					enhancer	enh				GGGCCGTGCCCGTTTCCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.104102344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4638	chr2	98612400	98612420	97995937	97995957	76857	hg19					enhancer	enh				GGCCCGCGAGCCCTGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				-0.1486746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4639	chr2	98612405	98612425	97995942	97995962	76858	hg19					enhancer	enh				GGCCAGCGCTCAGGGCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				0.056279582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4640	chr2	98612409	98612430	97995946	97995967	76859	hg19					enhancer	enh				GCCCTGAGCGCTGGCCTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	indirect	Non Significant	NA				0.181613473									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4641	chr2	98612413	98612435	97995950	97995972	76860	hg19					enhancer	enh				GCCCCTCGCAGGCCAGCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM131	direct	Highly Significant	NA				0.262454127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4642	chr2	99771328	99771350	99154865	99154887	76861	hg19					enhancer	enh				GTCTCTCCGCCTGCGGAGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.035690203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4643	chr2	99771337	99771357	99154874	99154894	76862	hg19					enhancer	enh				GCGCCTAGTCTCTCCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.533752223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4644	chr2	99771418	99771438	99154955	99154975	76863	hg19					enhancer	enh				GCATCGCGCGCAAGGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.172381149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4645	chr2	99771427	99771448	99154964	99154985	76864	hg19					enhancer	enh				GCAAGGCCTGCCGGTTGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.140967199									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4646	chr2	99771440	99771460	99154977	99154997	76865	hg19					enhancer	enh				GTCATACGACCCCGAGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.08582953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4647	chr2	99771440	99771462	99154977	99154999	76866	hg19					enhancer	enh				GCGTCATACGACCCCGAGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.889600442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4648	chr2	99771471	99771493	99155008	99155030	76867	hg19					enhancer	enh				GCTCGAGCCCTCACGAGGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.943532396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4649	chr2	99771471	99771491	99155008	99155028	76868	hg19					enhancer	enh				GGCCTCGTGAGGGCTCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.787302039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4650	chr2	99771481	99771502	99155018	99155039	76869	hg19					enhancer	enh				GTCGTACCCACGGCCTCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-1.384201302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4651	chr2	99771482	99771502	99155019	99155039	76870	hg19					enhancer	enh				GTCGTACCCACGGCCTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-1.407776021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4652	chr2	99771511	99771531	99155048	99155068	76871	hg19					enhancer	enh				GTTTCCGCTTCACCCACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.300254977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4653	chr2	99771511	99771533	99155048	99155070	76872	hg19					enhancer	enh				GCGTTTCCGCTTCACCCACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.16919871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4654	chr2	99771520	99771541	99155057	99155078	76873	hg19					enhancer	enh				GAAGCGGAAACGCTTCAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.611200575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4655	chr2	99771543	99771564	99155080	99155101	76874	hg19					enhancer	enh				GATGTTGCGGGCCGTAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				0.004748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4656	chr2	99771587	99771607	99155124	99155144	76875	hg19					enhancer	enh				GCGCGCGGTGTTTCTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.162040912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4657	chr2	99771615	99771635	99155152	99155172	76876	hg19					enhancer	enh				GACTTGCGGGTCGCCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LIPT1	indirect	Non Significant	NA				-0.113566595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4658	chr2	102759168	102759189	102142708	102142729	76877	hg19					enhancer	enh				GCTCTAGCCCCGCCGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.229251084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4659	chr2	102759168	102759190	102142708	102142730	76878	hg19					enhancer	enh				GGCTCTAGCCCCGCCGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				0.108771936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4660	chr2	102759180	102759201	102142720	102142741	76879	hg19					enhancer	enh				GGCTAGAGCCAGAGCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.345042708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4661	chr2	102759181	102759201	102142721	102142741	76880	hg19					enhancer	enh				GCTAGAGCCAGAGCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	direct	Highly Significant	NA				0.636328287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4662	chr2	102759191	102759211	102142731	102142751	76881	hg19					enhancer	enh				GGAACTGCCGGGCGCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.348707713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4663	chr2	102759191	102759212	102142731	102142752	76882	hg19					enhancer	enh				GGGAACTGCCGGGCGCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.047188193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4664	chr2	102759198	102759220	102142738	102142760	76883	hg19					enhancer	enh				GCCCGGCAGTTCCCGGCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				0.046172232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4665	chr2	102759198	102759219	102142738	102142759	76884	hg19					enhancer	enh				GCCCGGCAGTTCCCGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.190018893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4666	chr2	102759203	102759224	102142743	102142764	76885	hg19					enhancer	enh				GCAGTTCCCGGCCGCGAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.591128031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4667	chr2	102759203	102759224	102142743	102142764	76886	hg19					enhancer	enh				GCCCTCGCGGCCGGGAACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.208169859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4668	chr2	102759226	102759247	102142766	102142787	76887	hg19					enhancer	enh				GCGCAGCTTGTGGCCGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	direct	Highly Significant	NA				0.294523613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4669	chr2	102759238	102759258	102142778	102142798	76888	hg19					enhancer	enh				GCCGGCGGCCGGAGCCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				0.010882156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4670	chr2	102759242	102759264	102142782	102142804	76889	hg19					enhancer	enh				GCTCCGAGTCGGCTCCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				0.050483011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4671	chr2	102759249	102759271	102142789	102142811	76890	hg19					enhancer	enh				GCCGCGCGCTCCGAGTCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	direct	Highly Significant	NA				0.403905555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4672	chr2	102759251	102759273	102142791	102142813	76891	hg19					enhancer	enh				GCCGACTCGGAGCGCGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	direct	Highly Significant	NA				0.475754498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4673	chr2	102759275	102759295	102142815	102142835	76892	hg19					enhancer	enh				GCTCTCCGGCTCCTCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				0.038262746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4674	chr2	102759372	102759393	102142912	102142933	76893	hg19					enhancer	enh				GCGAGGAGTGCTTCGGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	IL1R1	indirect	Non Significant	NA				-0.149615808									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4675	chr2	105953928	105953950	105337471	105337493	76894	hg19					enhancer	enh				GTCACTCTGAGTCGCCGCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.609318816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4676	chr2	105953971	105953991	105337514	105337534	76895	hg19					enhancer	enh				GTTGCGGAAGTGACGTACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.214428872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4677	chr2	105953998	105954020	105337541	105337563	76896	hg19					enhancer	enh				GGCTACCCACAAAGCCCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.361832575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4678	chr2	105953998	105954019	105337541	105337562	76897	hg19					enhancer	enh				GCTACCCACAAAGCCCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				0.115258276									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4679	chr2	105954002	105954023	105337545	105337566	76898	hg19					enhancer	enh				GGGGCTTTGTGGGTAGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.449626924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4680	chr2	105954003	105954023	105337546	105337566	76899	hg19					enhancer	enh				GGGCTTTGTGGGTAGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.870500492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4681	chr2	105954005	105954025	105337548	105337568	76900	hg19					enhancer	enh				GCTTTGTGGGTAGCCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.236785755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4682	chr2	105954012	105954033	105337555	105337576	76901	hg19					enhancer	enh				GGGTAGCCGACTGGGGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.669789007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4683	chr2	105954013	105954033	105337556	105337576	76902	hg19					enhancer	enh				GGTAGCCGACTGGGGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.734796473									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4684	chr2	105954024	105954045	105337567	105337588	76903	hg19					enhancer	enh				GGGGTCTCCTGGCGACGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.302993174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4685	chr2	105954025	105954045	105337568	105337588	76904	hg19					enhancer	enh				GGGTCTCCTGGCGACGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.435047525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4686	chr2	105954053	105954075	105337596	105337618	76905	hg19					enhancer	enh				GATGTGGGCGGTCGCAGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				0.195805868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4687	chr2	105954059	105954081	105337602	105337624	76906	hg19					enhancer	enh				GGCGGTCGCAGCTGCACGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				0.037413344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4688	chr2	105954060	105954081	105337603	105337624	76907	hg19					enhancer	enh				GCGGTCGCAGCTGCACGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.123688252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4689	chr2	105954077	105954099	105337620	105337642	76908	hg19					enhancer	enh				GACTCGGAACTGCTGCTGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.027858451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4690	chr2	105954094	105954114	105337637	105337657	76909	hg19					enhancer	enh				GCACCCGGAGCTGCTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.208059485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4691	chr2	105954101	105954122	105337644	105337665	76910	hg19					enhancer	enh				GAACTCCTGGGACAGCAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.220911345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4692	chr2	105954115	105954135	105337658	105337678	76911	hg19					enhancer	enh				GGAGTTCCTTCTCCTCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	direct	Highly Significant	NA				0.296784653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-93685	chr2	105954143	105954163	105337686	105337706	76912	hg19	N/A	N/A	N/A	Enhatls100328	enhancer	enh				GTTGGGCGCGCCGGATCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf49	indirect	Non Significant	NA				-0.157885068	C2orf49	chr2	105337531	105349211	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5611
enhrx-lit4693	chr2	106468127	106468148	105851671	105851692	76913	hg19					enhancer	enh				GCCAATCAATGACAGCTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				-0.366169771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4694	chr2	106468157	106468177	105851701	105851721	76914	hg19					enhancer	enh				GAAGCAGTCTCACTGCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.36399066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4695	chr2	106468174	106468195	105851718	105851739	76915	hg19					enhancer	enh				GTGAGGCAGTTGTTGATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				0.07441703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4696	chr2	106468182	106468203	105851726	105851747	76916	hg19					enhancer	enh				GTTGTTGATTGGCTGGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				-0.194035714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4697	chr2	106468241	106468262	105851785	105851806	76917	hg19					enhancer	enh				GTGAAGTGGTCGTTTATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.389622914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4698	chr2	106468259	106468280	105851803	105851824	76918	hg19					enhancer	enh				GGCTGGCCCTCTGATATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				-0.782202608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4699	chr2	106468260	106468280	105851804	105851824	76919	hg19					enhancer	enh				GCTGGCCCTCTGATATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				0.059708731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4700	chr2	106468271	106468291	105851815	105851835	76920	hg19					enhancer	enh				GATATGAGGTGGTGGTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				-0.669840137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4701	chr2	106468316	106468337	105851860	105851881	76921	hg19					enhancer	enh				GCGAGCCGGACGTCGATTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.43146116									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4702	chr2	106468324	106468345	105851868	105851889	76922	hg19					enhancer	enh				GAAGACCAGTCAATCGACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.424390798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-93697	chr2	106468330	106468351	105851874	105851895	76923	hg19	N/A	N/A	N/A	Enhatls100347	enhancer	enh				GATTGACTGGTCTTCAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.260099255	NCK2	chr2	105744911	105894274	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5623
enhrx-93697	chr2	106468395	106468417	105851939	105851961	76924	hg19	N/A	N/A	N/A	Enhatls100347	enhancer	enh				GCTGTCATTGAGCCATTAAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.82652331	NCK2	chr2	105744911	105894274	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5623
enhrx-93697	chr2	106468398	106468418	105851942	105851962	76925	hg19	N/A	N/A	N/A	Enhatls100347	enhancer	enh				GTCATTGAGCCATTAAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	indirect	Non Significant	NA				0.184430464	NCK2	chr2	105744911	105894274	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5623
enhrx-93697	chr2	106468430	106468452	105851974	105851996	76926	hg19	N/A	N/A	N/A	Enhatls100347	enhancer	enh				GCCTATTGGTTAGCCATAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NCK2	direct	Highly Significant	NA				0.695881052	NCK2	chr2	105744911	105894274	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5623
enhrx-93714	chr2	106810580	106810601	106194124	106194145	76927	hg19	N/A	N/A	N/A	Enhatls100370	enhancer	enh				GAGTGCGCGCCCGCTGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				0.109789552	UXS1	chr2	106093310	106194301	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5640
enhrx-93714	chr2	106810591	106810612	106194135	106194156	76928	hg19	N/A	N/A	N/A	Enhatls100370	enhancer	enh				GCGCGCACTCACAGGCGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.085635343	UXS1	chr2	106093310	106194301	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5640
enhrx-lit4703	chr2	106810649	106810670	106194193	106194214	76929	hg19					enhancer	enh				GTGTCTGCCGTCAACCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.164778452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4704	chr2	106810678	106810700	106194222	106194244	76930	hg19					enhancer	enh				GCAGCGCCTTGCTCACCATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.980801987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4705	chr2	106810681	106810701	106194225	106194245	76931	hg19					enhancer	enh				GCGCCTTGCTCACCATCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.621401133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4706	chr2	106810687	106810707	106194231	106194251	76932	hg19					enhancer	enh				GCTCCCGGGGATGGTGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.770983736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4707	chr2	106810687	106810708	106194231	106194252	76933	hg19					enhancer	enh				GGCTCCCGGGGATGGTGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-1.24321214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4708	chr2	106810702	106810724	106194246	106194268	76934	hg19					enhancer	enh				GGCCCTGGACCCGCGCGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.665500197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4709	chr2	106810702	106810723	106194246	106194267	76935	hg19					enhancer	enh				GCCCTGGACCCGCGCGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.289493063									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4710	chr2	106810709	106810729	106194253	106194273	76936	hg19					enhancer	enh				GGTAGGGCCCTGGACCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.806206587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4711	chr2	106810712	106810732	106194256	106194276	76937	hg19					enhancer	enh				GGGTCCAGGGCCCTACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.136640111									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4712	chr2	106810713	106810735	106194257	106194279	76938	hg19					enhancer	enh				GGTCCAGGGCCCTACCGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.009536371									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4713	chr2	106810714	106810735	106194258	106194279	76939	hg19					enhancer	enh				GTCCAGGGCCCTACCGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.166089292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4714	chr2	106810736	106810758	106194280	106194302	76940	hg19					enhancer	enh				GGCCCGCCTGCTGCACAATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.545203219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4715	chr2	106810737	106810758	106194281	106194302	76941	hg19					enhancer	enh				GCCCGCCTGCTGCACAATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.50685101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4716	chr2	106810741	106810761	106194285	106194305	76942	hg19					enhancer	enh				GCCTGCTGCACAATGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.470343341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4717	chr2	106810745	106810765	106194289	106194309	76943	hg19					enhancer	enh				GCCGCCGCGCATTGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				-0.307799185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4718	chr2	106810898	106810919	106194442	106194463	76944	hg19					enhancer	enh				GCCTGCGGGTAGAGAAGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	indirect	Non Significant	NA				0.149577186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4719	chr2	106810914	106810935	106194458	106194479	76945	hg19					enhancer	enh				GAAAGGCGGCAACTGCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	UXS1	direct	Highly Significant	NA				0.248471425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4720	chr2	109065502	109065522	108449046	108449066	76946	hg19					enhancer	enh				GTCCGTCTAGACGTTCTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-0.127908993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4721	chr2	109065519	109065540	108449063	108449084	76947	hg19					enhancer	enh				GACTCCGCCCTTAGCGCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-0.639269022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4722	chr2	109065529	109065549	108449073	108449093	76948	hg19					enhancer	enh				GGTTCCCCGTACGGCGCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-0.218528643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4723	chr2	109065623	109065643	108449167	108449187	76949	hg19					enhancer	enh				GGTCAAAGGTCGCGCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	direct	Highly Significant	NA				0.364055546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4724	chr2	109065637	109065658	108449181	108449202	76950	hg19					enhancer	enh				GTAGGCTCTACTGCAGGTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				0.045288277									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4725	chr2	109065647	109065667	108449191	108449211	76951	hg19					enhancer	enh				GTAGAGCCTACGTCAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-1.113611543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4726	chr2	109065656	109065677	108449200	108449221	76952	hg19					enhancer	enh				GTTTGCGCCAGCCTCTGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				0.116077723									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4727	chr2	109065669	109065690	108449213	108449234	76953	hg19					enhancer	enh				GCGCAAACAGAAGTGCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	direct	Highly Significant	NA				0.379716472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4728	chr2	109065671	109065693	108449215	108449237	76954	hg19					enhancer	enh				GCAAACAGAAGTGCAGCGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-0.409294784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-93796	chr2	109065723	109065743	108449267	108449287	76955	hg19	N/A	N/A	N/A	Enhatls100456	enhancer	enh				GGCGGAGATGGAGGTAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-0.035102923	GCC2	chr2	108449106	108509415	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5722
enhrx-93796	chr2	109065727	109065747	108449271	108449291	76956	hg19	N/A	N/A	N/A	Enhatls100456	enhancer	enh				GAGATGGAGGTAACTCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	indirect	Non Significant	NA				-1.077315342	GCC2	chr2	108449106	108509415	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5722
enhrx-93796	chr2	109065754	109065775	108449298	108449319	76957	hg19	N/A	N/A	N/A	Enhatls100456	enhancer	enh				GAAGGCTTGATGGGAGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GCC2	direct	Highly Significant	NA				0.792060934	GCC2	chr2	108449106	108509415	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5722
enhrx-93958	chr2	110942213	110942234	110184636	110184657	76958	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GCACCTCTACCTGCATAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.489882528	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942225	110942247	110184648	110184670	76959	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GAAATCATAGCCCTCCTTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	direct	Highly Significant	NA				0.324237557	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942249	110942270	110184672	110184693	76960	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GTGGAAATCTCAAACGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	direct	Highly Significant	NA				0.289117516	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942277	110942299	110184700	110184722	76961	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GCCTTGACAATCTCAAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				0.123116185	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942315	110942336	110184738	110184759	76962	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GGGGTTTATGGATAGGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.100786662	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942315	110942335	110184738	110184758	76963	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GGGTTTATGGATAGGTAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.966546058	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942384	110942404	110184807	110184827	76964	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GATGGCAGCACCATTGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				0.117190253	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942411	110942433	110184834	110184856	76965	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GCTCAGGGGCCCGGAATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.245426705	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942416	110942436	110184839	110184859	76966	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GCAGCTCAGGGGCCCGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.3558437	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942429	110942450	110184852	110184873	76967	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GTCTGGCCTGAAGAGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.715209002	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942434	110942456	110184857	110184879	76968	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GCTCTTCAGGCCAGACTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-1.024582263	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942461	110942481	110184884	110184904	76969	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GGAGAGTGAAGGCATCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	direct	Highly Significant	NA				0.457210423	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942466	110942487	110184889	110184910	76970	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GTGAAGGCATCCACAAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				0.101373655	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942488	110942509	110184911	110184932	76971	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GACTTCTGGATGGCGAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.180900432	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942499	110942519	110184922	110184942	76972	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GTCCATGTCTGACTTCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				0.122796392	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-93958	chr2	110942521	110942543	110184944	110184966	76973	hg19	N/A	N/A	N/A	Enhatls100631	enhancer	enh				GTTGGAGAAAAGTGTGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NPHP1	indirect	Non Significant	NA				-0.019254281	NPHP1	chr2	110122310	110205066	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	5884
enhrx-lit4729	chr2	112641611	112641632	111884034	111884055	76974	hg19					enhancer	enh				GCGGCCCAAGAGTCACTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.19557232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4730	chr2	112641656	112641677	111884079	111884100	76975	hg19					enhancer	enh				GTTCTTCCTCCAGAATAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.881238543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4731	chr2	112641661	112641681	111884084	111884104	76976	hg19					enhancer	enh				GCCCGTTCTTCCTCCAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.001558759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4732	chr2	112641670	112641690	111884093	111884113	76977	hg19					enhancer	enh				GAAGAACGGGCAACAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-2.190986263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4733	chr2	112641685	112641705	111884108	111884128	76978	hg19					enhancer	enh				GCAGCGGGCTCGAGTGCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-1.935460429									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4734	chr2	112641688	112641709	111884111	111884132	76979	hg19					enhancer	enh				GCGGGCTCGAGTGCTAATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-2.814249124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4735	chr2	112641692	112641713	111884115	111884136	76980	hg19					enhancer	enh				GCTCGAGTGCTAATGGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.701023887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4736	chr2	112641711	112641733	111884134	111884156	76981	hg19					enhancer	enh				GAAGGCGTGCGAGACGTTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	direct	Highly Significant	NA				0.301626864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4737	chr2	112641745	112641766	111884168	111884189	76982	hg19					enhancer	enh				GGCAAGACGGGAAAGTCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-1.463552097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4738	chr2	112641745	112641765	111884168	111884188	76983	hg19					enhancer	enh				GCAAGACGGGAAAGTCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-1.838617229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4739	chr2	112641758	112641779	111884181	111884202	76984	hg19					enhancer	enh				GTCTTGCCTCGCGCCGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.274402232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4740	chr2	112641758	112641778	111884181	111884201	76985	hg19					enhancer	enh				GCCCCGGCGCGAGGCAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.186153492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4741	chr2	112641795	112641815	111884218	111884238	76986	hg19					enhancer	enh				GCGCGGCGTCCTAGCAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-1.257226351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4742	chr2	112641823	112641844	111884246	111884267	76987	hg19					enhancer	enh				GCGGTCTTCCCTCAACAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.853118077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4743	chr2	112641838	112641858	111884261	111884281	76988	hg19					enhancer	enh				GACCGCGGCGGGTTACAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.105364984									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4744	chr2	112641876	112641896	111884299	111884319	76989	hg19					enhancer	enh				GTTCGCATCAGTCGCACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.545133457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4745	chr2	112641883	112641904	111884306	111884327	76990	hg19					enhancer	enh				GACTGATGCGAACCCCGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				0.14754812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4746	chr2	112641927	112641948	111884350	111884371	76991	hg19					enhancer	enh				GCTAAAGAGAACTTGGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANAPC1	indirect	Non Significant	NA				-0.359163891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-94168	chr2	113012478	113012500	112254901	112254923	76992	hg19	N/A	N/A	N/A	Enhatls100844	enhancer	enh				GATCACCTTTCGTCAGAGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.832970089	ZC3H8	chr2	112211528	112255042	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6094
enhrx-lit4747	chr2	113012500	113012520	112254923	112254943	76993	hg19					enhancer	enh				GGCCCTCGGCAAAACGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.524320673									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4748	chr2	113012568	113012588	112254991	112255011	76994	hg19					enhancer	enh				GGTCCTCCCTTTCGCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	direct	Highly Significant	NA				0.238529									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4749	chr2	113012574	113012595	112254997	112255018	76995	hg19					enhancer	enh				GCTTCCCGGCTCGCGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.787832381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4750	chr2	113012577	113012598	112255000	112255021	76996	hg19					enhancer	enh				GTAGCTTCCCGGCTCGCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-2.24926503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4751	chr2	113012578	113012598	112255001	112255021	76997	hg19					enhancer	enh				GTAGCTTCCCGGCTCGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-2.296631504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4752	chr2	113012619	113012640	112255042	112255063	76998	hg19					enhancer	enh				GACAACCCGGACGCGACGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-1.878838602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4753	chr2	113012627	113012647	112255050	112255070	76999	hg19					enhancer	enh				GGGTCCGTCTCGTCGCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-1.281521328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4754	chr2	113012636	113012658	112255059	112255081	77000	hg19					enhancer	enh				GAGACGGACCCAGAGCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.163093888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4755	chr2	113012638	113012659	112255061	112255082	77001	hg19					enhancer	enh				GACGGACCCAGAGCCGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-1.690771105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4756	chr2	113012638	113012658	112255061	112255081	77002	hg19					enhancer	enh				GACGGACCCAGAGCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.722191197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4757	chr2	113012648	113012670	112255071	112255093	77003	hg19					enhancer	enh				GCCTGTGGCCCTGGCGCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-1.289425852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4758	chr2	113012697	113012717	112255120	112255140	77004	hg19					enhancer	enh				GGGCGGTGCAGCGCATGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.067762528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4759	chr2	113012705	113012727	112255128	112255150	77005	hg19					enhancer	enh				GCTGCACCGCCCTCCGCGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.079823547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4760	chr2	113012717	113012737	112255140	112255160	77006	hg19					enhancer	enh				GGCCTGCCCAGAGTCGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	indirect	Non Significant	NA				-0.669110128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4761	chr2	113012756	113012777	112255179	112255200	77007	hg19					enhancer	enh				GCCTGCGCAGAGCCGAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	direct	Highly Significant	NA				0.232176238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4762	chr2	113012781	113012803	112255204	112255226	77008	hg19					enhancer	enh				GCTTACAGAAGGGCAACCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZC3H8	direct	Highly Significant	NA				0.541178306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4763	chr2	113403355	113403375	112645778	112645798	77009	hg19					enhancer	enh				GGGCCAATGAGCGCCACCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.158251887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4764	chr2	113403461	113403481	112645884	112645904	77010	hg19					enhancer	enh				GGTCACGCGGGTCGCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				0.151882441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4765	chr2	113403471	113403493	112645894	112645916	77011	hg19					enhancer	enh				GTCGCTGCGCGGGCTATAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-2.51388878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4766	chr2	113403471	113403492	112645894	112645915	77012	hg19					enhancer	enh				GTCGCTGCGCGGGCTATAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.551632819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4767	chr2	113403477	113403498	112645900	112645921	77013	hg19					enhancer	enh				GCGCGGGCTATAAGTAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.539632292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4768	chr2	113403482	113403503	112645905	112645926	77014	hg19					enhancer	enh				GGCTATAAGTAGGGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-1.103259783									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4769	chr2	113403483	113403503	112645906	112645926	77015	hg19					enhancer	enh				GCTATAAGTAGGGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.500142265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4770	chr2	113403502	113403522	112645925	112645945	77016	hg19					enhancer	enh				GGGGTGCTCCGCTGGAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.057366327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4771	chr2	113403507	113403529	112645930	112645952	77017	hg19					enhancer	enh				GCTCCGCTGGAGTGATGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	direct	Highly Significant	NA				0.340559986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4772	chr2	113403513	113403533	112645936	112645956	77018	hg19					enhancer	enh				GCCGGCAGCCATCACTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.895640406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4773	chr2	113403513	113403535	112645936	112645958	77019	hg19					enhancer	enh				GCGCCGGCAGCCATCACTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.311707769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4774	chr2	113403523	113403543	112645946	112645966	77020	hg19					enhancer	enh				GGCTGCCGGCGCTCTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				0.054514571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4775	chr2	113403531	113403552	112645954	112645975	77021	hg19					enhancer	enh				GAAGAACCACGCAGAGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.570758449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4776	chr2	113403573	113403595	112645996	112646018	77022	hg19					enhancer	enh				GACCTTCCCAGGAAGCAGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.099321189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4777	chr2	113403586	113403606	112646009	112646029	77023	hg19					enhancer	enh				GCGGGACTCACGACCTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				0.135732654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4778	chr2	113403597	113403617	112646020	112646040	77024	hg19					enhancer	enh				GAGTCCCGCTGAGCTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.113342799									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4779	chr2	113403604	113403624	112646027	112646047	77025	hg19					enhancer	enh				GGCACCGGGGACAGCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.854965151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4780	chr2	113403609	113403631	112646032	112646054	77026	hg19					enhancer	enh				GCTGTCCCCGGTGCCGCCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC20A1	indirect	Non Significant	NA				-0.145194557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-94291	chr2	113931439	113931460	113173862	113173883	77027	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTGTGAGGTGTTGAGCAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				0.146243656	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931448	113931468	113173871	113173891	77028	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTTGAGCAGCTAGGGAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-1.203421209	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931535	113931555	113173958	113173978	77029	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTGAATGTGGCTGTGACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.229866368	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931535	113931555	113173958	113173978	77030	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GCCGTCACAGCCACATTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-1.035326131	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931535	113931556	113173958	113173979	77031	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GCCGTCACAGCCACATTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.393072547	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931548	113931568	113173971	113173991	77032	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTCGGCTTGCCCAGTGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.054134736	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931556	113931576	113173979	113173999	77033	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GGGCAAGCCGACTGTGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.850574963	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931577	113931598	113174000	113174021	77034	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GGAAGTGCTCTTGGGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.055362175	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931578	113931598	113174001	113174021	77035	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GAAGTGCTCTTGGGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.416869034	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931604	113931624	113174027	113174047	77036	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GGACCCAAGAATGGATGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				0.099303076	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931620	113931641	113174043	113174064	77037	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTCCTTTGGAGGTGAGCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.838643607	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931620	113931641	113174043	113174064	77038	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GTCCTTTGGAGGTGAGCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.838643607	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931620	113931642	113174043	113174065	77039	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GTCCTTTGGAGGTGAGCTAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.303668638	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931620	113931642	113174043	113174065	77040	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GTCCTTTGGAGGTGAGCTAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.303668638	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931625	113931647	113174048	113174070	77041	hg19	N/A	enh5778	N/A	N/A	enhancer	enh				GACCCACTTAGCTCACCTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				0.104734933	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931625	113931647	113174048	113174070	77042	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GACCCACTTAGCTCACCTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				0.104734933	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931630	113931652	113174053	113174075	77043	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GGTGAGCTAAGTGGGTCTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.350057817	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931631	113931652	113174054	113174075	77044	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GTGAGCTAAGTGGGTCTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	indirect	Non Significant	NA				-0.350676951	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931635	113931656	113174058	113174079	77045	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GCTAAGTGGGTCTGCCTAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.332606722	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-94291	chr2	113931695	113931717	113174118	113174140	77046	hg19	N/A	enh5778	N/A	Enhatls100970	enhancer	enh				GTCACATGTGGGTCCTTGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PSD4	direct	Highly Significant	NA				0.462659055	PSD4	chr2	113173970	113209396	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6217
enhrx-lit4781	chr2	114647502	114647522	113889925	113889945	77047	hg19					enhancer	enh				GCCTGGCCTGGCCGGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.11287474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4782	chr2	114647507	114647528	113889930	113889951	77048	hg19					enhancer	enh				GCCTGGCCGGGGCGTCGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.114253229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4783	chr2	114647533	114647555	113889956	113889978	77049	hg19					enhancer	enh				GCCATCTTGGCTTCCCGGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.254715855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4784	chr2	114647663	114647683	113890086	113890106	77050	hg19					enhancer	enh				GGCTATCACTTCCGCAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.288897515									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4785	chr2	114647663	114647685	113890086	113890108	77051	hg19					enhancer	enh				GCGGCTATCACTTCCGCAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	direct	Highly Significant	NA				0.422928543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4786	chr2	114647684	114647705	113890107	113890128	77052	hg19					enhancer	enh				GAAAGCAGCAGGCTCGGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.093432529									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4787	chr2	114647687	114647709	113890110	113890132	77053	hg19					enhancer	enh				GCAAGAAAGCAGCAGGCTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.755248868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4788	chr2	114647691	114647712	113890114	113890135	77054	hg19					enhancer	enh				GTAGCAAGAAAGCAGCAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-1.319763408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4789	chr2	114647696	114647718	113890119	113890141	77055	hg19					enhancer	enh				GAAGCAGTAGCAAGAAAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.240671913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4790	chr2	114647735	114647755	113890158	113890178	77056	hg19					enhancer	enh				GGGCCGCCTTCACCGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.225756372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4791	chr2	114647736	114647758	113890159	113890181	77057	hg19					enhancer	enh				GCTGGGCCGCCTTCACCGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.094181819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4792	chr2	114647744	114647764	113890167	113890187	77058	hg19					enhancer	enh				GAAGGCGGCCCAGCTGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				-0.100666124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4793	chr2	114647755	114647776	113890178	113890199	77059	hg19					enhancer	enh				GCTATCTGACCATCCACAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				0.054708311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4794	chr2	114647756	114647776	113890179	113890199	77060	hg19					enhancer	enh				GCTATCTGACCATCCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				0.124530195									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4795	chr2	114647778	114647799	113890201	113890222	77061	hg19					enhancer	enh				GAGATTGGCGGCGGGAGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	indirect	Non Significant	NA				0.01580234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4796	chr2	114647794	114647815	113890217	113890238	77062	hg19					enhancer	enh				GTGCTGCTAGGGGCCAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	direct	Highly Significant	NA				0.986879311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4797	chr2	114647805	114647827	113890228	113890250	77063	hg19					enhancer	enh				GCCGTCTGCTCCGTGCTGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACTR3	direct	Highly Significant	NA				0.225752248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4798	chr2	120124240	120124260	119366664	119366684	77064	hg19					enhancer	enh				GGACGGAGACCGAAGAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				0.068102694									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4799	chr2	120124298	120124320	119366722	119366744	77065	hg19					enhancer	enh				GGTCGAGAGTTGGGTTCAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-0.450020237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4800	chr2	120124298	120124319	119366722	119366743	77066	hg19					enhancer	enh				GTCGAGAGTTGGGTTCAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.780075588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4801	chr2	120124310	120124330	119366734	119366754	77067	hg19					enhancer	enh				GCCGGGAGTTGGTCGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				0.053609373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4802	chr2	120124355	120124376	119366779	119366800	77068	hg19					enhancer	enh				GCCGGGAACAGGTGGGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				0.089752802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4803	chr2	120124367	120124388	119366791	119366812	77069	hg19					enhancer	enh				GCCGAAGGGGACGCCGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-2.344287021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4804	chr2	120124373	120124394	119366797	119366818	77070	hg19					enhancer	enh				GGCGTCCCCTTCGGCTACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				0.1316641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4805	chr2	120124373	120124393	119366797	119366817	77071	hg19					enhancer	enh				GAGTAGCCGAAGGGGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.314632439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4806	chr2	120124396	120124416	119366820	119366840	77072	hg19					enhancer	enh				GGGACCGCTTGCGCAAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-0.370564081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4807	chr2	120124398	120124419	119366822	119366843	77073	hg19					enhancer	enh				GTTTGCGCAAGCGGTCCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.238771572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4808	chr2	120124404	120124426	119366828	119366850	77074	hg19					enhancer	enh				GCAAGCGGTCCCACGTGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.532507299									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4809	chr2	120124404	120124425	119366828	119366849	77075	hg19					enhancer	enh				GCAAGCGGTCCCACGTGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-0.051434032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4810	chr2	120124408	120124429	119366832	119366853	77076	hg19					enhancer	enh				GCGGTCCCACGTGGGCTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.564459903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4811	chr2	120124410	120124431	119366834	119366855	77077	hg19					enhancer	enh				GGTCCCACGTGGGCTCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.393698204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4812	chr2	120124411	120124431	119366835	119366855	77078	hg19					enhancer	enh				GTCCCACGTGGGCTCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	direct	Highly Significant	NA				0.611736988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4813	chr2	120124417	120124439	119366841	119366863	77079	hg19					enhancer	enh				GCTAGCCCCGCCCGAGCCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-0.039334474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4814	chr2	120124496	120124516	119366920	119366940	77080	hg19					enhancer	enh				GGTGCTCGCCCGAGCAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				-0.723147914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4815	chr2	120124553	120124575	119366977	119366999	77081	hg19					enhancer	enh				GAAGCGATCGCCCAGATTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf76	indirect	Non Significant	NA				0.052192718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4816	chr2	120189272	120189292	119431696	119431716	77082	hg19					enhancer	enh				GGATTACGCTGAGTCAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.005235802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4817	chr2	120189325	120189346	119431749	119431770	77083	hg19					enhancer	enh				GCTCGGCGATTAACCCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.288827142									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4818	chr2	120189326	120189346	119431750	119431770	77084	hg19					enhancer	enh				GCTCGGCGATTAACCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.547965509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4819	chr2	120189386	120189407	119431810	119431831	77085	hg19					enhancer	enh				GACTTCTCCGCAGGGGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.261532572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4820	chr2	120189389	120189409	119431813	119431833	77086	hg19					enhancer	enh				GGGACTTCTCCGCAGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	direct	Highly Significant	NA				0.306178271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4821	chr2	120189391	120189413	119431815	119431837	77087	hg19					enhancer	enh				GCCCGGGACTTCTCCGCAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-1.02734884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4822	chr2	120189395	120189417	119431819	119431841	77088	hg19					enhancer	enh				GCCAGCCCGGGACTTCTCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				0.195136872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4823	chr2	120189396	120189417	119431820	119431841	77089	hg19					enhancer	enh				GCCAGCCCGGGACTTCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.099943406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4824	chr2	120189401	120189422	119431825	119431846	77090	hg19					enhancer	enh				GAAGTCCCGGGCTGGCGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.388651292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4825	chr2	120189410	120189432	119431834	119431856	77091	hg19					enhancer	enh				GCTGTGGCCGCCGGCGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				0.101092485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4826	chr2	120189411	120189431	119431835	119431855	77092	hg19					enhancer	enh				GCTGGCGCCGGCGGCCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.671000005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4827	chr2	120189420	120189440	119431844	119431864	77093	hg19					enhancer	enh				GGCGGCCACAGCGGAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.204880223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4828	chr2	120189430	120189451	119431854	119431875	77094	hg19					enhancer	enh				GCGGAGCAGCTGGAGCGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.225307769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4829	chr2	120189442	120189462	119431866	119431886	77095	hg19					enhancer	enh				GAGCGATCGAGGCTGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.133766833									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4830	chr2	120189450	120189470	119431874	119431894	77096	hg19					enhancer	enh				GAGGCTGCAGCGCGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				-0.261418805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4831	chr2	120189477	120189498	119431901	119431922	77097	hg19					enhancer	enh				GCATGACTGCCGTCGGCGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM37	indirect	Non Significant	NA				0.189953825									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4832	chr2	120770542	120770562	120012966	120012986	77098	hg19					enhancer	enh				GCGCCGGCCAATTTCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				-0.251046318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4833	chr2	120770608	120770629	120013032	120013053	77099	hg19					enhancer	enh				GAGCTGGGAGGGAGCTTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	direct	Highly Significant	NA				0.349458208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4834	chr2	120770621	120770641	120013045	120013065	77100	hg19					enhancer	enh				GCTTTAAGGGGTGGACGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	direct	Highly Significant	NA				0.293964121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4835	chr2	120770651	120770671	120013075	120013095	77101	hg19					enhancer	enh				GGTCCTCCGGGGATTAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				0.179046977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4836	chr2	120770652	120770674	120013076	120013098	77102	hg19					enhancer	enh				GTCCTCCGGGGATTAGAGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				-0.133390523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4837	chr2	120770657	120770679	120013081	120013103	77103	hg19					enhancer	enh				GCCCACCGGCTCTAATCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	direct	Highly Significant	NA				0.345722939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4838	chr2	120770660	120770681	120013084	120013105	77104	hg19					enhancer	enh				GAGCCCACCGGCTCTAATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				-0.262095643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4839	chr2	120770673	120770693	120013097	120013117	77105	hg19					enhancer	enh				GGCGCCCACAACGAGCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				-0.081349613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4840	chr2	120770690	120770711	120013114	120013135	77106	hg19					enhancer	enh				GCCATTTCTCGGCGTCTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				0.179873495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4841	chr2	120770722	120770742	120013146	120013166	77107	hg19					enhancer	enh				GCCGAGCAAGGCTGAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	direct	Highly Significant	NA				0.282258601									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4842	chr2	120770734	120770754	120013158	120013178	77108	hg19					enhancer	enh				GAGCGGGGAAGAGCCGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				-0.209434685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4843	chr2	120770740	120770762	120013164	120013186	77109	hg19					enhancer	enh				GCTCTTCCCCGCTCTGGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EPB41L5	indirect	Non Significant	NA				0.077423283									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4844	chr2	120980789	120980809	120223213	120223233	77110	hg19					enhancer	enh				GCGGCGCGGCGGTTACAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	direct	Highly Significant	NA				0.868407182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4845	chr2	120980800	120980821	120223224	120223245	77111	hg19					enhancer	enh				GTTACAAACTGGGCGCTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				0.099704829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4846	chr2	120980838	120980858	120223262	120223282	77112	hg19					enhancer	enh				GATGGGTACGGAGTGAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.232596342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4847	chr2	120980897	120980918	120223321	120223342	77113	hg19					enhancer	enh				GCGCGCTGCTGACTCCCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	direct	Highly Significant	NA				0.930325065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4848	chr2	120980916	120980936	120223340	120223360	77114	hg19					enhancer	enh				GCCCAAGGTCGCGGGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.475385676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4849	chr2	120980924	120980946	120223348	120223370	77115	hg19					enhancer	enh				GGAAGCGTCCGCCCAAGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.276172853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4850	chr2	120980924	120980945	120223348	120223369	77116	hg19					enhancer	enh				GAAGCGTCCGCCCAAGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.234707044									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4851	chr2	120980933	120980955	120223357	120223379	77117	hg19					enhancer	enh				GGCGGACGCTTCCAGGCGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.166248292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4852	chr2	120980934	120980955	120223358	120223379	77118	hg19					enhancer	enh				GCGGACGCTTCCAGGCGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.108530727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4853	chr2	120980947	120980969	120223371	120223393	77119	hg19					enhancer	enh				GGCGACTCCGGGAACATGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				0.014483087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4854	chr2	120980948	120980969	120223372	120223393	77120	hg19					enhancer	enh				GCGACTCCGGGAACATGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	direct	Highly Significant	NA				0.498848669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4855	chr2	120980978	120981000	120223402	120223424	77121	hg19					enhancer	enh				GCTCACATCCTCCCTGCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.186005316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4856	chr2	120980978	120980999	120223402	120223423	77122	hg19					enhancer	enh				GCTCACATCCTCCCTGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TMEM185B	indirect	Non Significant	NA				-0.462455774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4857	chr2	122406862	122406883	121649286	121649307	77123	hg19					enhancer	enh				GACCCGGCGCCCGCCACTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.328071621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4858	chr2	122406868	122406889	121649292	121649313	77124	hg19					enhancer	enh				GCGCCCGCCACTGCGCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	direct	Highly Significant	NA				0.47426095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4859	chr2	122406878	122406899	121649302	121649323	77125	hg19					enhancer	enh				GCCCTGGCCCCTCCCGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.262516403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4860	chr2	122406895	122406917	121649319	121649341	77126	hg19					enhancer	enh				GACCCGAGCCCTCTCGCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.209251566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4861	chr2	122406901	122406921	121649325	121649345	77127	hg19					enhancer	enh				GTCAGACCCGAGCCCTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.524135963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4862	chr2	122406930	122406950	121649354	121649374	77128	hg19					enhancer	enh				GCTGTAAGTACCCGGTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.232351053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4863	chr2	122406931	122406951	121649355	121649375	77129	hg19					enhancer	enh				GGCTGTAAGTACCCGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-1.179472383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4864	chr2	122406973	122406993	121649397	121649417	77130	hg19					enhancer	enh				GGCGGCTCTCTGGTCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.083333724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4865	chr2	122406973	122406995	121649397	121649419	77131	hg19					enhancer	enh				GCGGCGGCTCTCTGGTCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.135037463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4866	chr2	122406993	122407014	121649417	121649438	77132	hg19					enhancer	enh				GCCTTCTCCTCCACCCCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				0.137258963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4867	chr2	122407003	122407023	121649427	121649447	77133	hg19					enhancer	enh				GCTTAACCTCATTGGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.320832179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4868	chr2	122407003	122407025	121649427	121649449	77134	hg19					enhancer	enh				GCGCTTAACCTCATTGGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.093212788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4869	chr2	122407013	122407033	121649437	121649457	77135	hg19					enhancer	enh				GAGGTTAAGCGCTTGGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CLASP1	indirect	Non Significant	NA				-0.418326531									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-94652	chr2	122494267	122494287	121736691	121736711	77136	hg19	N/A	N/A	N/A	Enhatls101352	enhancer	enh				GGCGATGGACCGGGTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-0.886404665	NIFK	chr2	121726944	121736911	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6578
enhrx-94652	chr2	122494291	122494313	121736715	121736737	77137	hg19	N/A	N/A	N/A	Enhatls101352	enhancer	enh				GCACCCTGGCCCAGGCTGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-0.419004141	NIFK	chr2	121726944	121736911	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6578
enhrx-94652	chr2	122494302	122494322	121736726	121736746	77138	hg19	N/A	N/A	N/A	Enhatls101352	enhancer	enh				GGCCAGGGTGCCTGCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				0.188103886	NIFK	chr2	121726944	121736911	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6578
enhrx-lit4870	chr2	122494323	122494343	121736747	121736767	77139	hg19					enhancer	enh				GGTTCGCAAGCGCATAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	direct	Highly Significant	NA				0.48847735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4871	chr2	122494437	122494458	121736861	121736882	77140	hg19					enhancer	enh				GCGCCGCGTGGTTAGCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-2.423651686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4872	chr2	122494440	122494461	121736864	121736885	77141	hg19					enhancer	enh				GGAGCGCCGCGTGGTTAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-4.760043732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4873	chr2	122494440	122494460	121736864	121736884	77142	hg19					enhancer	enh				GAGCGCCGCGTGGTTAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-3.001004684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4874	chr2	122494450	122494471	121736874	121736895	77143	hg19					enhancer	enh				GACGTTTCCGGGAGCGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-1.237450933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4875	chr2	122494451	122494471	121736875	121736895	77144	hg19					enhancer	enh				GCGGCGCTCCCGGAAACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-2.679620297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4876	chr2	122494489	122494510	121736913	121736934	77145	hg19					enhancer	enh				GTCCTGCCTCTACTTCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-0.031521814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4877	chr2	122494519	122494540	121736943	121736964	77146	hg19					enhancer	enh				GCGAAGCGCTAAGGCGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-1.147296832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4878	chr2	122494559	122494579	121736983	121737003	77147	hg19					enhancer	enh				GAGGGCCATGAGTCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-0.113671434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4879	chr2	122494580	122494600	121737004	121737024	77148	hg19					enhancer	enh				GGGTTGGAGCAGGAGTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	indirect	Non Significant	NA				-0.347371988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4880	chr2	122494588	122494610	121737012	121737034	77149	hg19					enhancer	enh				GCAGGAGTTGCCCGGAGAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIFK	direct	Highly Significant	NA				0.325309999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4881	chr2	127413702	127413722	126656126	126656146	77150	hg19					enhancer	enh				GGGTCACACTCCTCCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.015884125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4882	chr2	127413702	127413722	126656126	126656146	77151	hg19					enhancer	enh				GCGCGGGAGGAGTGTGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.475822334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4883	chr2	127413723	127413744	126656147	126656168	77152	hg19					enhancer	enh				GCGGCGAGAGGAAGCGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				0.126270204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4884	chr2	127413726	127413747	126656150	126656171	77153	hg19					enhancer	enh				GCCGCTTCCTCTCGCCGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.300734268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4885	chr2	127413726	127413746	126656150	126656170	77154	hg19					enhancer	enh				GCCGCTTCCTCTCGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.411175576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4886	chr2	127413730	127413752	126656154	126656176	77155	hg19					enhancer	enh				GACCCTCGGCGGCGAGAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.363205925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4887	chr2	127413736	127413758	126656160	126656182	77156	hg19					enhancer	enh				GCTCCTGACCCTCGGCGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.237562878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4888	chr2	127413739	127413759	126656163	126656183	77157	hg19					enhancer	enh				GCCGCCGAGGGTCAGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.503324325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4889	chr2	127413746	127413766	126656170	126656190	77158	hg19					enhancer	enh				GCTCCCGGGCTCCTGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.440639517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4890	chr2	127413746	127413768	126656170	126656192	77159	hg19					enhancer	enh				GCGCTCCCGGGCTCCTGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.168427212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4891	chr2	127413756	127413778	126656180	126656202	77160	hg19					enhancer	enh				GCCCGGGAGCGCGACCCTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.01630931									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4892	chr2	127413789	127413811	126656213	126656235	77161	hg19					enhancer	enh				GGCCCGGCCTGGCCAGTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.335403625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4893	chr2	127413790	127413811	126656214	126656235	77162	hg19					enhancer	enh				GCCCGGCCTGGCCAGTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.668812696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4894	chr2	127413794	127413816	126656218	126656240	77163	hg19					enhancer	enh				GACCGCGGGGACTGGCCAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.53623159									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4895	chr2	127413799	127413821	126656223	126656245	77164	hg19					enhancer	enh				GCAGAGACCGCGGGGACTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				0.042375394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4896	chr2	127413810	127413831	126656234	126656255	77165	hg19					enhancer	enh				GTCAGCCCGGGCAGAGACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				-0.390439786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4897	chr2	127413852	127413872	126656276	126656296	77166	hg19					enhancer	enh				GAAGCCCCAACAGCACGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	direct	Highly Significant	NA				0.60511222									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-94701	chr2	127413882	127413902	126656306	126656326	77167	hg19	N/A	N/A	N/A	Enhatls101401	enhancer	enh				GCCTCGGTGAGTACCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				0.088391235	GYPC	chr2	126656157	126696667	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6627
enhrx-94701	chr2	127413888	127413908	126656312	126656332	77168	hg19	N/A	N/A	N/A	Enhatls101401	enhancer	enh				GTGAGTACCCGCCGTGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GYPC	indirect	Non Significant	NA				0.114238641	GYPC	chr2	126656157	126696667	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6627
enhrx-94718	chr2	127822414	127822434	127064838	127064858	77169	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GGTGAGTCACAGACCCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.139774746	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822435	127822457	127064859	127064881	77170	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GGTGCCCAGCCCGCCCAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				0.049401019	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822436	127822457	127064860	127064881	77171	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GTGCCCAGCCCGCCCAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.029459891	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822442	127822462	127064866	127064886	77172	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCCCCTTCCCTGGGCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	direct	Highly Significant	NA				0.290325244	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822459	127822481	127064883	127064905	77173	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GGCTGTGCTGGCTCACTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	direct	Highly Significant	NA				0.379249824	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822460	127822481	127064884	127064905	77174	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCTGTGCTGGCTCACTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	direct	Highly Significant	NA				0.3358735	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822469	127822491	127064893	127064915	77175	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCTCACTGCGGGAGGACACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	direct	Highly Significant	NA				0.328045222	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822493	127822514	127064917	127064938	77176	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GAATCCCTGAGTCACTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				0.129374934	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822535	127822556	127064959	127064980	77177	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GAAAGTGTCAGGCCCCGCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.018015281	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822550	127822570	127064974	127064994	77178	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCGGGAAGTTTCCCTAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				0.021194505	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822555	127822577	127064979	127065001	77179	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCTGCTGGCGGGAAGTTTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.442872908	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822572	127822594	127064996	127065018	77180	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCAGCCTCACGTTCTCAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.329883113	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822608	127822628	127065032	127065052	77181	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GCTGGGCCGCCTTCTGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				0.054818009	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94718	chr2	127822637	127822659	127065061	127065083	77182	hg19	N/A	enh62840	N/A	Enhatls101420	enhancer	enh				GTTAAGTGGCCTTCCGGCCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	BIN1	indirect	Non Significant	NA				-0.090582156	BIN1	chr2	127048026	127107288	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6644
enhrx-94843	chr2	128568568	128568589	127810994	127811015	77183	hg19	N/A	N/A	N/A	Enhatls101554	enhancer	enh				GTCGCCGCCGCACTCACCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-1.86258739	WDR33	chr2	127701026	127811187	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6769
enhrx-lit4898	chr2	128568701	128568723	127811127	127811149	77184	hg19					enhancer	enh				GAGCAGCCGCCATCTTCCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-1.200003421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4899	chr2	128568703	128568723	127811129	127811149	77185	hg19					enhancer	enh				GCAGCCGCCATCTTCCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.041975152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4900	chr2	128568710	128568731	127811136	127811157	77186	hg19					enhancer	enh				GTGGCCCATAGGGGAAGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-5.866999092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4901	chr2	128568721	128568742	127811147	127811168	77187	hg19					enhancer	enh				GCGTGCGTTCGGTGGCCCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.139659853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4902	chr2	128568722	128568742	127811148	127811168	77188	hg19					enhancer	enh				GCGTGCGTTCGGTGGCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-1.113009534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4903	chr2	128568724	128568744	127811150	127811170	77189	hg19					enhancer	enh				GGGCCACCGAACGCACGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-5.772996055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4904	chr2	128568730	128568751	127811156	127811177	77190	hg19					enhancer	enh				GACCCCAGAGCGTGCGTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.025196358									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4905	chr2	128568740	128568760	127811166	127811186	77191	hg19					enhancer	enh				GCTCTGGGGTCATCACGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.850614081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4906	chr2	128568746	128568768	127811172	127811194	77192	hg19					enhancer	enh				GGGTCATCACGCACTGGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-1.991108095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4907	chr2	128568747	128568768	127811173	127811194	77193	hg19					enhancer	enh				GGTCATCACGCACTGGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.876601811									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4908	chr2	128568748	128568768	127811174	127811194	77194	hg19					enhancer	enh				GTCATCACGCACTGGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-2.236758877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4909	chr2	128568769	128568789	127811195	127811215	77195	hg19					enhancer	enh				GGCGCTACGTCACGCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	direct	Highly Significant	NA				0.36918593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4910	chr2	128568777	128568797	127811203	127811223	77196	hg19					enhancer	enh				GTCACGCGCGCCTGGACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-0.201069361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4911	chr2	128568844	128568865	127811270	127811291	77197	hg19					enhancer	enh				GCTCTGCAGGGTCTCGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-0.359605184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4912	chr2	128568849	128568870	127811275	127811296	77198	hg19					enhancer	enh				GAAGCGCTCTGCAGGGTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-0.973302921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4913	chr2	128568872	128568893	127811298	127811319	77199	hg19					enhancer	enh				GTCCTACTCGCTCCGGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-0.810894554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4914	chr2	128568880	128568900	127811306	127811326	77200	hg19					enhancer	enh				GTAGCGCGTCCTACTCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-1.076838301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4915	chr2	128568886	128568907	127811312	127811333	77201	hg19					enhancer	enh				GTAGGACGCGCTACCTCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	WDR33	indirect	Non Significant	NA				-0.710207574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4916	chr2	128785539	128785559	128027965	128027985	77202	hg19					enhancer	enh				GGAGCGAGCTCAAGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-1.428132941									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4917	chr2	128785547	128785568	128027973	128027994	77203	hg19					enhancer	enh				GAGCGCGCGGGAGCGAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				0.046672006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4918	chr2	128785561	128785583	128027987	128028009	77204	hg19					enhancer	enh				GGCCCCACAGACGGAGAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.082124278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4919	chr2	128785561	128785582	128027987	128028008	77205	hg19					enhancer	enh				GCCCCACAGACGGAGAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.020073172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4920	chr2	128785571	128785592	128027997	128028018	77206	hg19					enhancer	enh				GTCTGTGGGGCCGACGTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.148054329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4921	chr2	128785572	128785592	128027998	128028018	77207	hg19					enhancer	enh				GGGGACGTCGGCCCCACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.649672966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4922	chr2	128785584	128785604	128028010	128028030	77208	hg19					enhancer	enh				GGTCCGGAGCCTGGGGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.489734646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4923	chr2	128785592	128785613	128028018	128028039	77209	hg19					enhancer	enh				GTGGCTGCGGGTCCGGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.455547588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4924	chr2	128785594	128785616	128028020	128028042	77210	hg19					enhancer	enh				GCTCCGGACCCGCAGCCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.133279266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4925	chr2	128785606	128785628	128028032	128028054	77211	hg19					enhancer	enh				GCTAGCTCCCCGGCGGTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	direct	Highly Significant	NA				0.459178065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4926	chr2	128785612	128785632	128028038	128028058	77212	hg19					enhancer	enh				GAGTGCTAGCTCCCCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-2.560965667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4927	chr2	128785615	128785635	128028041	128028061	77213	hg19					enhancer	enh				GCAGAGTGCTAGCTCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.482361882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4928	chr2	128785618	128785638	128028044	128028064	77214	hg19					enhancer	enh				GGGGCAGAGTGCTAGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.188933638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4929	chr2	128785645	128785666	128028071	128028092	77215	hg19					enhancer	enh				GAAGCAGCGGCGCTGGAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SAP130	indirect	Non Significant	NA				-0.27427894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4930	chr2	129076367	129076387	128318793	128318813	77216	hg19					enhancer	enh				GCGCTGTGCTGGCCGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.068590188									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4931	chr2	129076372	129076392	128318798	128318818	77217	hg19					enhancer	enh				GGAGAGCGCTGTGCTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.046297944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4932	chr2	129076422	129076444	128318848	128318870	77218	hg19					enhancer	enh				GCAGAGCGTTCTCGGCGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.56046562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4933	chr2	129076427	129076447	128318853	128318873	77219	hg19					enhancer	enh				GGCGCAGAGCGTTCTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.751996204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4934	chr2	129076427	129076449	128318853	128318875	77220	hg19					enhancer	enh				GCGGCGCAGAGCGTTCTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				0.155865786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4935	chr2	129076516	129076536	128318942	128318962	77221	hg19					enhancer	enh				GACGGCAAGAGACGCCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.64545164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4936	chr2	129076560	129076582	128318986	128319008	77222	hg19					enhancer	enh				GAACCCCGGCACTCCGGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.233858989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4937	chr2	129076565	129076585	128318991	128319011	77223	hg19					enhancer	enh				GGCGAACCCCGGCACTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	indirect	Non Significant	NA				-0.104161315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4938	chr2	129076576	129076598	128319002	128319024	77224	hg19					enhancer	enh				GCCCAGCACCCGCGGCGAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	direct	Highly Significant	NA				0.447504705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4939	chr2	129076616	129076636	128319042	128319062	77225	hg19					enhancer	enh				GCGGTGGCGAGGCCGCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HS6ST1	direct	Highly Significant	NA				0.477883207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4940	chr2	130939642	130939662	130182069	130182089	77226	hg19					enhancer	enh				GGCGCTCTAGGAGCCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-3.78232796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4941	chr2	130939648	130939669	130182075	130182096	77227	hg19					enhancer	enh				GCTGAGCGGCGCTCTAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.499435308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4942	chr2	130939694	130939714	130182121	130182141	77228	hg19					enhancer	enh				GGGCTTCAATGACGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.007373676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4943	chr2	130939764	130939784	130182191	130182211	77229	hg19					enhancer	enh				GGCCAGACGTTGACGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.030386778									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4944	chr2	130939769	130939790	130182196	130182217	77230	hg19					enhancer	enh				GACGTTGACGCTGCAGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.194985428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4945	chr2	130939792	130939812	130182219	130182239	77231	hg19					enhancer	enh				GTGGTGGGCGCAGCCGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	direct	Highly Significant	NA				0.237713685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4946	chr2	130939822	130939844	130182249	130182271	77232	hg19					enhancer	enh				GGGGCGGAGCGCACCTTTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	direct	Highly Significant	NA				0.299273482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4947	chr2	130939823	130939844	130182250	130182271	77233	hg19					enhancer	enh				GGGCGGAGCGCACCTTTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.130979365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4948	chr2	130939824	130939844	130182251	130182271	77234	hg19					enhancer	enh				GGCGGAGCGCACCTTTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.740240974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4949	chr2	130939828	130939850	130182255	130182277	77235	hg19					enhancer	enh				GAGCGCACCTTTCCGCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.103479697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4950	chr2	130939830	130939851	130182257	130182278	77236	hg19					enhancer	enh				GCGCACCTTTCCGCGGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.271762899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4951	chr2	130939830	130939850	130182257	130182277	77237	hg19					enhancer	enh				GCGCACCTTTCCGCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.236741836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4952	chr2	130939850	130939870	130182277	130182297	77238	hg19					enhancer	enh				GCCCTGCGCCGCCATCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.031292402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4953	chr2	130939919	130939939	130182346	130182366	77239	hg19					enhancer	enh				GGCAGAAGCTGGCGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				0.107874742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4954	chr2	130939926	130939946	130182353	130182373	77240	hg19					enhancer	enh				GCTGGCGCTGCGGCGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.16745691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4955	chr2	130939941	130939961	130182368	130182388	77241	hg19					enhancer	enh				GAAGAAGGTGCTGAGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				-0.103178678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4956	chr2	130939971	130939991	130182398	130182418	77242	hg19					enhancer	enh				GCTGTACGAGCTGGCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MZT2B	indirect	Non Significant	NA				0.08687742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4957	chr2	131113554	131113575	130355981	130356002	77243	hg19					enhancer	enh				GCCAATGGAAGCGCGCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.736911168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4958	chr2	131113582	131113604	130356009	130356031	77244	hg19					enhancer	enh				GCAAGGGCGGGGACTCAGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				0.104068429									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4959	chr2	131113619	131113639	130356046	130356066	77245	hg19					enhancer	enh				GCGGCGAGTGTGGACGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.162240041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4960	chr2	131113622	131113644	130356049	130356071	77246	hg19					enhancer	enh				GCGTCCACACTCGCCGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				0.050771272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4961	chr2	131113624	131113644	130356051	130356071	77247	hg19					enhancer	enh				GTCCACACTCGCCGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				0.037777125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4962	chr2	131113652	131113673	130356079	130356100	77248	hg19					enhancer	enh				GGGCTGGACCTTGCTGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.215198508									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4963	chr2	131113653	131113673	130356080	130356100	77249	hg19					enhancer	enh				GGCTGGACCTTGCTGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.305839897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4964	chr2	131113672	131113692	130356099	130356119	77250	hg19					enhancer	enh				GCTGCGGCTCATGGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.433175365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4965	chr2	131113672	131113693	130356099	130356120	77251	hg19					enhancer	enh				GGCTGCGGCTCATGGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.027557817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4966	chr2	131113677	131113699	130356104	130356126	77252	hg19					enhancer	enh				GCCATGAGCCGCAGCCTGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.234877213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4967	chr2	131113681	131113703	130356108	130356130	77253	hg19					enhancer	enh				GCCGAGTCCAGGCTGCGGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.268081867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4968	chr2	131113684	131113704	130356111	130356131	77254	hg19					enhancer	enh				GCCGCAGCCTGGACTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				0.056771293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4969	chr2	131113694	131113714	130356121	130356141	77255	hg19					enhancer	enh				GGAAGCTCCGCGCCGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.502069021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4970	chr2	131113703	131113723	130356130	130356150	77256	hg19					enhancer	enh				GCGGAGCTTCCTGGAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.044148418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4971	chr2	131113715	131113737	130356142	130356164	77257	hg19					enhancer	enh				GCCCCGCGCTTCCAGCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				-0.355636686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-94984	chr2	131113758	131113778	130356185	130356205	77258	hg19	N/A	N/A	N/A	Enhatls101702	enhancer	enh				GCCGGCGAGTTCAGCGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PTPN18	indirect	Non Significant	NA				0.046747358	PTPN18	chr2	130356044	130375405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	6910
enhrx-lit4972	chr2	135676245	135676266	134918675	134918696	77259	hg19					enhancer	enh				GACTAGGGCGAGTCGGTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.491588537									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4973	chr2	135676269	135676289	134918699	134918719	77260	hg19					enhancer	enh				GCCCCGCGCATGCGCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.116174958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4974	chr2	135676312	135676332	134918742	134918762	77261	hg19					enhancer	enh				GGTGCGTGGTCTACGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.281665469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4975	chr2	135676317	135676337	134918747	134918767	77262	hg19					enhancer	enh				GTGGTCTACGGCGAGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.031173677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4976	chr2	135676410	135676432	134918840	134918862	77263	hg19					enhancer	enh				GAGGAGGAAGTGTCATGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.437752256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4977	chr2	135676412	135676432	134918842	134918862	77264	hg19					enhancer	enh				GGAGGAAGTGTCATGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	direct	Highly Significant	NA				0.458766192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4978	chr2	135676416	135676438	134918846	134918868	77265	hg19					enhancer	enh				GAAGTGTCATGGCGTCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.56176868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4979	chr2	135676433	135676454	134918863	134918884	77266	hg19					enhancer	enh				GGCCGTGGAGCTTCTTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	direct	Highly Significant	NA				0.262009197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4980	chr2	135676434	135676454	134918864	134918884	77267	hg19					enhancer	enh				GCCGTGGAGCTTCTTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				0.028054454									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4981	chr2	135676438	135676460	134918868	134918890	77268	hg19					enhancer	enh				GAACCAGCGAGAAGAAGCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				0.093132389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4982	chr2	135676455	135676476	134918885	134918906	77269	hg19					enhancer	enh				GGTTCTTTACTCGGGAACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	direct	Highly Significant	NA				0.311103331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4983	chr2	135676456	135676476	134918886	134918906	77270	hg19					enhancer	enh				GTTCTTTACTCGGGAACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.216117088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4984	chr2	135676480	135676501	134918910	134918931	77271	hg19					enhancer	enh				GAACACGCCGAGCCGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.011458915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4985	chr2	135676489	135676509	134918919	134918939	77272	hg19					enhancer	enh				GAGCCGCCGCTGCGGAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCNT2	indirect	Non Significant	NA				-0.020367862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4986	chr2	136742970	136742991	135985400	135985421	77273	hg19					enhancer	enh				GATCATGGACGCGGCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-1.785619196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4987	chr2	136742976	136742996	135985406	135985426	77274	hg19					enhancer	enh				GCCGCGTCCATGATCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-3.076465368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4988	chr2	136742980	136743000	135985410	135985430	77275	hg19					enhancer	enh				GCCGCGGGAGATCATGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.549162335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4989	chr2	136742986	136743006	135985416	135985436	77276	hg19					enhancer	enh				GGAGAAGCCGCGGGAGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-2.299197163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4990	chr2	136742998	136743019	135985428	135985449	77277	hg19					enhancer	enh				GCTTCTCCTGACTCTTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.252711966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4991	chr2	136743007	136743029	135985437	135985459	77278	hg19					enhancer	enh				GCCAGCGCCAGCCGCAAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-1.691762231									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4992	chr2	136743017	136743039	135985447	135985469	77279	hg19					enhancer	enh				GCTGGCGCTGGCGCTGGGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.865124954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4993	chr2	136743023	136743045	135985453	135985475	77280	hg19					enhancer	enh				GCTGGCGCTGGGCATCGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	direct	Highly Significant	NA				0.208468231									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4994	chr2	136743029	136743051	135985459	135985481	77281	hg19					enhancer	enh				GCTGGGCATCGGGACACGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.110843478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4995	chr2	136743032	136743052	135985462	135985482	77282	hg19					enhancer	enh				GGGCATCGGGACACGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-2.276977273									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4996	chr2	136743057	136743078	135985487	135985508	77283	hg19					enhancer	enh				GTGGACACCACCCTCCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-1.699510913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4997	chr2	136743071	136743093	135985501	135985523	77284	hg19					enhancer	enh				GCCTTACGGAAGCCTGCGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.339313809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4998	chr2	136743075	136743097	135985505	135985527	77285	hg19					enhancer	enh				GCCTGCCTTACGGAAGCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.630679921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit4999	chr2	136743079	136743100	135985509	135985530	77286	hg19					enhancer	enh				GGCTTCCGTAAGGCAGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-0.507929417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5000	chr2	136743080	136743100	135985510	135985530	77287	hg19					enhancer	enh				GCTTCCGTAAGGCAGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-1.318411196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5001	chr2	136743122	136743142	135985552	135985572	77288	hg19					enhancer	enh				GTCTCCGCCCTCCCGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DARS	indirect	Non Significant	NA				-1.938815059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-95564	chr2	145277553	145277574	144519986	144520007	77289	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GCATGAAGAAGCCGCGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-2.103296967	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277588	145277610	144520021	144520043	77290	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GTGGAAGCGAAGAAACAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-2.973869664	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277590	145277610	144520023	144520043	77291	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GGAAGCGAAGAAACAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-2.0301866	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277633	145277653	144520066	144520086	77292	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GCCTCCCGACACTCTTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-1.812519643	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277654	145277675	144520087	144520108	77293	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GGACCGTTATTCCTGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-1.336456093	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277655	145277675	144520088	144520108	77294	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GACCGTTATTCCTGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-1.559992166	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277668	145277690	144520101	144520123	77295	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GATCAGTTCTAACCTGCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-1.135013111	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277697	145277719	144520130	144520152	77296	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GCCACTCCAGGAAACACAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-2.479776895	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277720	145277741	144520153	144520174	77297	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GTAACACGTCAGTCCGTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-2.007847771	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-95564	chr2	145277807	145277828	144520240	144520261	77298	hg19	N/A	enh5907	N/A	N/A	enhancer	enh				GCGCCACCTATCTTTGTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ZEB2	indirect	Non Significant	NA				-0.137690812	ZEB2	chr2	144364363	144521057	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7490
enhrx-lit5002	chr2	148601912	148601932	147844343	147844363	77299	hg19					enhancer	enh				GATTGTCGGGGAAGCGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.151872113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5003	chr2	148601924	148601944	147844355	147844375	77300	hg19					enhancer	enh				GGAGCGCGAGGAGATTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.67904131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5004	chr2	148602006	148602027	147844437	147844458	77301	hg19					enhancer	enh				GCGCAGCGGAGGAACGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.176895989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5005	chr2	148602030	148602052	147844461	147844483	77302	hg19					enhancer	enh				GCTTCCAGCTTCGGGCCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	direct	Highly Significant	NA				0.400035645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5006	chr2	148602043	148602064	147844474	147844495	77303	hg19					enhancer	enh				GGCCGGAACCGGAAGTTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.524352953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5007	chr2	148602044	148602064	147844475	147844495	77304	hg19					enhancer	enh				GCCGGAACCGGAAGTTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.040683561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5008	chr2	148602078	148602100	147844509	147844531	77305	hg19					enhancer	enh				GGAGGCCAGGAGACCGAAAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	direct	Highly Significant	NA				1.301448849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5009	chr2	148602079	148602100	147844510	147844531	77306	hg19					enhancer	enh				GAGGCCAGGAGACCGAAAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				0.013636935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5010	chr2	148602089	148602110	147844520	147844541	77307	hg19					enhancer	enh				GACCGAAAACGCGGCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.34362803									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5011	chr2	148602101	148602123	147844532	147844554	77308	hg19					enhancer	enh				GGCCGAGCCCGGAGCCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.122822337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5012	chr2	148602102	148602123	147844533	147844554	77309	hg19					enhancer	enh				GCCGAGCCCGGAGCCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.898938799									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5013	chr2	148602131	148602153	147844562	147844584	77310	hg19					enhancer	enh				GGCCAAGTTCTGGTCCAGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.303653297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5014	chr2	148602131	148602152	147844562	147844583	77311	hg19					enhancer	enh				GCCAAGTTCTGGTCCAGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.226509372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5015	chr2	148602137	148602159	147844568	147844590	77312	hg19					enhancer	enh				GGCGGCGGCCAAGTTCTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.342823573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5016	chr2	148602137	148602158	147844568	147844589	77313	hg19					enhancer	enh				GCGGCGGCCAAGTTCTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	direct	Highly Significant	NA				0.536535834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5017	chr2	148602227	148602248	147844658	147844679	77314	hg19					enhancer	enh				GACCACTGGCGGCCGAGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	direct	Highly Significant	NA				0.284196581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5018	chr2	148602262	148602282	147844693	147844713	77315	hg19					enhancer	enh				GTCTGGGTTGAAGGTCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR2A	indirect	Non Significant	NA				-0.404539384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5019	chr2	148778107	148778127	148020538	148020558	77316	hg19					enhancer	enh				GCGCAAGGTGAATCGAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-0.125883646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5020	chr2	148778145	148778165	148020576	148020596	77317	hg19					enhancer	enh				GGTAAACTTGCTGCAAACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-0.212972431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5021	chr2	148778193	148778213	148020624	148020644	77318	hg19					enhancer	enh				GCATTTACCAGGTCAAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	direct	Highly Significant	NA				0.259607259									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5022	chr2	148778203	148778225	148020634	148020656	77319	hg19					enhancer	enh				GCGTTGGTTCCCCTCTTTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-0.019134324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5023	chr2	148778221	148778241	148020652	148020672	77320	hg19					enhancer	enh				GAAGCGATTCCTGCAGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-0.582529082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5024	chr2	148778230	148778252	148020661	148020683	77321	hg19					enhancer	enh				GGAATCGCTTCACCGAATCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				0.171508582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5025	chr2	148778231	148778252	148020662	148020683	77322	hg19					enhancer	enh				GAATCGCTTCACCGAATCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	direct	Highly Significant	NA				0.654291506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5026	chr2	148778253	148778273	148020684	148020704	77323	hg19					enhancer	enh				GTCTAGCAGAGGACGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				0.149990775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5027	chr2	148778258	148778279	148020689	148020710	77324	hg19					enhancer	enh				GGTGAAGTCTAGCAGAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-2.118046133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5028	chr2	148778258	148778278	148020689	148020709	77325	hg19					enhancer	enh				GTGAAGTCTAGCAGAGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-1.604454129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5029	chr2	148778264	148778285	148020695	148020716	77326	hg19					enhancer	enh				GCGGCAGGTGAAGTCTAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-1.503785321									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5030	chr2	148778266	148778287	148020697	148020718	77327	hg19					enhancer	enh				GCTAGACTTCACCTGCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-0.149244508									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5031	chr2	148778280	148778302	148020711	148020733	77328	hg19					enhancer	enh				GTTGTGTACGGTCCGCAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-1.658910535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5032	chr2	148778284	148778305	148020715	148020736	77329	hg19					enhancer	enh				GTGGTTGTGTACGGTCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				-1.605201032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5033	chr2	148778288	148778308	148020719	148020739	77330	hg19					enhancer	enh				GGACCGTACACAACCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	indirect	Non Significant	NA				0.100702632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5034	chr2	148778309	148778329	148020740	148020760	77331	hg19					enhancer	enh				GTGCGTGCGCGGGGCATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ORC4	direct	Highly Significant	NA				0.259413628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5035	chr2	150444096	150444116	149587582	149587602	77332	hg19					enhancer	enh				GAAAATACGGGCAATACCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.443676844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5036	chr2	150444136	150444157	149587622	149587643	77333	hg19					enhancer	enh				GCAAATTTGGAGGGGCTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.532321132									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5037	chr2	150444170	150444190	149587656	149587676	77334	hg19					enhancer	enh				GTGGTGGTGACTGGTACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.395793557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5038	chr2	150444174	150444194	149587660	149587680	77335	hg19					enhancer	enh				GACAGTGGTGGTGACTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.672255108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5039	chr2	150444191	150444211	149587677	149587697	77336	hg19					enhancer	enh				GTCTCCAGCTGTCCCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.410652191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5040	chr2	150444198	150444218	149587684	149587704	77337	hg19					enhancer	enh				GAGTCCGGTTCTGGGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.200420356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5041	chr2	150444213	150444233	149587699	149587719	77338	hg19					enhancer	enh				GACTCTTCCTGCCATCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				0.19724847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5042	chr2	150444223	150444245	149587709	149587731	77339	hg19					enhancer	enh				GCCATCAAAATGGCGGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				0.032884316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5043	chr2	150444247	150444269	149587733	149587755	77340	hg19					enhancer	enh				GCAGCGGTGGTAGCACCTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.365041725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5044	chr2	150444250	150444272	149587736	149587758	77341	hg19					enhancer	enh				GCGGTGGTAGCACCTACGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.293859619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5045	chr2	150444252	150444272	149587738	149587758	77342	hg19					enhancer	enh				GGTGGTAGCACCTACGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				0.063934781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5046	chr2	150444259	150444280	149587745	149587766	77343	hg19					enhancer	enh				GCACCTACGCTGGCGGTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				0.060057376									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5047	chr2	150444301	150444322	149587787	149587808	77344	hg19					enhancer	enh				GCATCATCGTTTCGACGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.313309953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5048	chr2	150444314	150444335	149587800	149587821	77345	hg19					enhancer	enh				GATGATGCGCACGCGCAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				-0.611021401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5049	chr2	150444322	150444344	149587808	149587830	77346	hg19					enhancer	enh				GCACGCGCAAAGTAGGCCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				-0.394831127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5050	chr2	150444351	150444373	149587837	149587859	77347	hg19					enhancer	enh				GACCTGCCATTGGGTAAACGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				-0.055212348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5051	chr2	150444356	150444377	149587842	149587863	77348	hg19					enhancer	enh				GCCATTGGGTAAACGCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.682562558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5052	chr2	150444422	150444442	149587908	149587928	77349	hg19					enhancer	enh				GGCTTCCGACCTGCGTTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				0.033895554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5053	chr2	150444434	150444456	149587920	149587942	77350	hg19					enhancer	enh				GATTAACTGACCCGCCTAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	direct	Highly Significant	NA				0.550607698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5054	chr2	150444469	150444489	149587955	149587975	77351	hg19					enhancer	enh				GAGGACTATCAAACGCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MMADHC	indirect	Non Significant	NA				-0.277529893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-95676	chr2	152118174	152118194	151261660	151261680	77352	hg19	N/A	N/A	N/A	Enhatls102438	enhancer	enh				GGGGACCATGGCGACGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.646282067	RBM43	chr2	151247939	151261863	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7602
enhrx-95676	chr2	152118182	152118204	151261668	151261690	77353	hg19	N/A	N/A	N/A	Enhatls102438	enhancer	enh				GTCCGTGCCTGTACCGTCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.667951825	RBM43	chr2	151247939	151261863	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	7602
enhrx-lit5055	chr2	152118245	152118265	151261731	151261751	77354	hg19					enhancer	enh				GAGGGGAGACGCGCCCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.723860244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5056	chr2	152118261	152118281	151261747	151261767	77355	hg19					enhancer	enh				GGGCTTTCTGCGGCCGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				0.108556512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5057	chr2	152118267	152118289	151261753	151261775	77356	hg19					enhancer	enh				GCCGCAGAAAGCCCACAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.29196946									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5058	chr2	152118277	152118297	151261763	151261783	77357	hg19					enhancer	enh				GCCCACAACCAGCGGAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.803551817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5059	chr2	152118358	152118378	151261844	151261864	77358	hg19					enhancer	enh				GGAGGCTACGAAGAAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				1.299438797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5060	chr2	152118375	152118396	151261861	151261882	77359	hg19					enhancer	enh				GGGCGGTCCTTCCACCCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.329081492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5061	chr2	152118376	152118396	151261862	151261882	77360	hg19					enhancer	enh				GGCGGTCCTTCCACCCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.275920465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5062	chr2	152118385	152118405	151261871	151261891	77361	hg19					enhancer	enh				GAACAGCCGGATCGGGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.002789128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5063	chr2	152118389	152118411	151261875	151261897	77362	hg19					enhancer	enh				GTCGCAGAACAGCCGGATCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.123216925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5064	chr2	152118392	152118412	151261878	151261898	77363	hg19					enhancer	enh				GGTCGCAGAACAGCCGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.021135673									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5065	chr2	152118393	152118414	151261879	151261900	77364	hg19					enhancer	enh				GAGGTCGCAGAACAGCCGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.370613187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5066	chr2	152118398	152118419	151261884	151261905	77365	hg19					enhancer	enh				GCCACGAGGTCGCAGAACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.270943281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5067	chr2	152118468	152118488	151261954	151261974	77366	hg19					enhancer	enh				GCAAAACTACGGAGGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	indirect	Non Significant	NA				-0.092858058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5068	chr2	152118513	152118533	151261999	151262019	77367	hg19					enhancer	enh				GGCCGAGAGGATTCCTCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RBM43	direct	Highly Significant	NA				0.368849128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5069	chr2	153032163	153032185	152175649	152175671	77368	hg19					enhancer	enh				GCAGCGACTAGGGCTCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				-0.196305366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5070	chr2	153032169	153032189	152175655	152175675	77369	hg19					enhancer	enh				GACAGCAGCGACTAGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				-0.407509081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5071	chr2	153032176	153032197	152175662	152175683	77370	hg19					enhancer	enh				GTCAGCTAGACAGCAGCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				-0.070518901									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5072	chr2	153032208	153032228	152175694	152175714	77371	hg19					enhancer	enh				GCTACCCGCCGGGTGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				-0.165743318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5073	chr2	153032219	153032240	152175705	152175726	77372	hg19					enhancer	enh				GAGCCGCGGCCGCGGGTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				-0.812534104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5074	chr2	153032227	153032248	152175713	152175734	77373	hg19					enhancer	enh				GGTCTAGGGAGCCGCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				0.089829561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5075	chr2	153032227	153032247	152175713	152175733	77374	hg19					enhancer	enh				GTCTAGGGAGCCGCGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				0.039984483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5076	chr2	153032291	153032313	152175777	152175799	77375	hg19					enhancer	enh				GCCCGGCTCTTGCCTGACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				0.0461826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5077	chr2	153032295	153032317	152175781	152175803	77376	hg19					enhancer	enh				GCCGGCCTGTCAGGCAAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	direct	Highly Significant	NA				0.316902568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5078	chr2	153032296	153032318	152175782	152175804	77377	hg19					enhancer	enh				GCTCTTGCCTGACAGGCCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STAM2	indirect	Non Significant	NA				0.052244438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5079	chr2	158114301	158114322	157257789	157257810	77378	hg19					enhancer	enh				GTGGCTGGAATCAACTGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.033373341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5080	chr2	158114340	158114360	157257828	157257848	77379	hg19					enhancer	enh				GTGTTTATCAGAACTTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-1.052861254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5081	chr2	158114367	158114388	157257855	157257876	77380	hg19					enhancer	enh				GAGCATCTGTGCCTGCTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				0.097234024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5082	chr2	158114384	158114406	157257872	157257894	77381	hg19					enhancer	enh				GCTCTGCTATGAAATGCCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.065154494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5083	chr2	158114407	158114427	157257895	157257915	77382	hg19					enhancer	enh				GGCAGAGACTGACAAGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.390587099									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5084	chr2	158114425	158114446	157257913	157257934	77383	hg19					enhancer	enh				GTAGGAACTGAGCTTTCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				0.1764208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5085	chr2	158114444	158114464	157257932	157257952	77384	hg19					enhancer	enh				GCAGGAAGCAGCAGTCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	direct	Highly Significant	NA				0.400530749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5086	chr2	158114452	158114473	157257940	157257961	77385	hg19					enhancer	enh				GCTGCTTCCTGCTGTGTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				0.019989594									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5087	chr2	158114455	158114477	157257943	157257965	77386	hg19					enhancer	enh				GCTTCCTGCTGTGTTCAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				0.00330846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5088	chr2	158114455	158114476	157257943	157257964	77387	hg19					enhancer	enh				GCTTCCTGCTGTGTTCAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.296519242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5089	chr2	158114537	158114558	157258025	157258046	77388	hg19					enhancer	enh				GCCTGCTTACCTTGAGTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.262663217									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5090	chr2	158114548	158114569	157258036	157258057	77389	hg19					enhancer	enh				GTAAGCAGGCTAAGGGAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				0.120583687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5091	chr2	158114556	158114578	157258044	157258066	77390	hg19					enhancer	enh				GCTAAGGGAGGGCAGGCTGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.018184087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5092	chr2	158114579	158114600	157258067	157258088	77391	hg19					enhancer	enh				GGAAAGCTTTGTACCATGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	direct	Highly Significant	NA				0.425520461									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5093	chr2	158114580	158114600	157258068	157258088	77392	hg19					enhancer	enh				GAAAGCTTTGTACCATGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.119805834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5094	chr2	158114660	158114682	157258148	157258170	77393	hg19					enhancer	enh				GTCATCTGGCTCCTCTTTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GALNT5	indirect	Non Significant	NA				-0.509521826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5095	chr2	158732664	158732685	157876152	157876173	77394	hg19					enhancer	enh				GCGGGCAGAATAAACTTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.104644743									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5096	chr2	158732671	158732693	157876159	157876181	77395	hg19					enhancer	enh				GAATAAACTTCCCGAGGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.044900134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5097	chr2	158732695	158732717	157876183	157876205	77396	hg19					enhancer	enh				GCTCGGGCTGGGAGCACGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.540265672									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5098	chr2	158732701	158732721	157876189	157876209	77397	hg19					enhancer	enh				GCTGGGAGCACGACCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.186053062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5099	chr2	158732729	158732751	157876217	157876239	77398	hg19					enhancer	enh				GCGGACCAGCTGGGCTTGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				0.128124999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5100	chr2	158732731	158732751	157876219	157876239	77399	hg19					enhancer	enh				GGACCAGCTGGGCTTGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.076637395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5101	chr2	158732821	158732842	157876309	157876330	77400	hg19					enhancer	enh				GCGGCGGCGGCTGCAAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	direct	Highly Significant	NA				0.260747326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5102	chr2	158732826	158732848	157876314	157876336	77401	hg19					enhancer	enh				GGCGGCTGCAAAGAGCAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	direct	Highly Significant	NA				0.402538991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5103	chr2	158732827	158732848	157876315	157876336	77402	hg19					enhancer	enh				GCGGCTGCAAAGAGCAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				0.133991945									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5104	chr2	158732833	158732853	157876321	157876341	77403	hg19					enhancer	enh				GCAAAGAGCAGGAGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-3.233162392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5105	chr2	158732879	158732899	157876367	157876387	77404	hg19					enhancer	enh				GGAAGTGGCTGCGGAGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.674532351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5106	chr2	158732911	158732931	157876399	157876419	77405	hg19					enhancer	enh				GTCTGGAGCTGTGATTAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	direct	Highly Significant	NA				0.263923665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5107	chr2	158732932	158732952	157876420	157876440	77406	hg19					enhancer	enh				GGAAATGATGTGTTGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				-0.242520211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5108	chr2	158732953	158732974	157876441	157876462	77407	hg19					enhancer	enh				GCTCCCTGGATCCGCGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACVR1	indirect	Non Significant	NA				0.158580807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96599	chr2	168689701	168689721	167833191	167833211	77408	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GAGTGAATCGAAACTCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	direct	Highly Significant	NA				0.308639238	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689712	168689732	167833202	167833222	77409	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GATTCACTCTCACTGTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				-0.268907426	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689816	168689838	167833306	167833328	77410	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GGAGGCTTAGCTGTATGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	direct	Highly Significant	NA				0.242145934	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689817	168689838	167833307	167833328	77411	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GAGGCTTAGCTGTATGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				0.127064874	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689836	168689856	167833326	167833346	77412	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GATGGCAGTATCTCCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	direct	Highly Significant	NA				0.393943799	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689857	168689878	167833347	167833368	77413	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GGTTATGAATATGAAACTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				-0.125599967	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689858	168689878	167833348	167833368	77414	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GTTATGAATATGAAACTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	direct	Highly Significant	NA				0.436284477	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689863	168689883	167833353	167833373	77415	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GAATATGAAACTCACAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				0.125681449	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689912	168689932	167833402	167833422	77416	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GAGGCACTAGGGATTATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	direct	Highly Significant	NA				0.403278877	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689923	168689944	167833413	167833434	77417	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GATTATGGCAGGTCATACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				-0.035642072	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96599	chr2	168689934	168689954	167833424	167833444	77418	hg19	N/A	N/A	N/A	Enhatls103404	enhancer	enh				GTCATACAGTGGGTATCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	B3GALT1	indirect	Non Significant	NA				-0.220942854	B3GALT1	chr2	167293000	167874045	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8525
enhrx-96803	chr2	170521464	170521484	169664954	169664974	77419	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GGGATGTAGTGTCATCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.126563728	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521471	170521493	169664961	169664983	77420	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GACACTACATCCCAAGAAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.205974355	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521494	170521516	169664984	169665006	77421	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GGTAGAAAGTATTACTCACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.21845455	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521495	170521516	169664985	169665006	77422	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GTAGAAAGTATTACTCACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.699600434	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521515	170521535	169665005	169665025	77423	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GAGGGACTCCTGGGAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.202445457	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521515	170521536	169665005	169665026	77424	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GAGGGACTCCTGGGAAGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.259817432	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521519	170521540	169665009	169665030	77425	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GACTCCTGGGAAGAGCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				0.120178615	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521526	170521546	169665016	169665036	77426	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GTGCCTGCCCAGCTCTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				0.028143442	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521528	170521550	169665018	169665040	77427	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GAAGAGCTGGGCAGGCACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.310852271	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521557	170521578	169665047	169665068	77428	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GATTGCTTTGGACAAAGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.353719709	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521557	170521577	169665047	169665067	77429	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GATTGCTTTGGACAAAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.381153247	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521587	170521609	169665077	169665099	77430	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GACTGAGGAAAAGTTTCTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.438442993	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521591	170521613	169665081	169665103	77431	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GAGGAAAAGTTTCTGAGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.580414884	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521591	170521612	169665081	169665102	77432	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GAGGAAAAGTTTCTGAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-1.017237822	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521593	170521613	169665083	169665103	77433	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GGAAAAGTTTCTGAGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-0.364348867	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521627	170521649	169665117	169665139	77434	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GCACTTGTGCCAAAAGAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	direct	Highly Significant	NA				0.719973729	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521680	170521700	169665170	169665190	77435	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GTACAGATGTAGGGCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				0.014379546	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-96803	chr2	170521688	170521708	169665178	169665198	77436	hg19	N/A	enh19007	N/A	Enhatls103612	enhancer	enh				GTAGGGCCAAAAGGGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC173	indirect	Non Significant	NA				-1.524396299	CFAP210	chr2	169645424	169694405	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8729
enhrx-lit5109	chr2	170550793	170550814	169694283	169694304	77437	hg19					enhancer	enh				GGTACGGTTTGGACGGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.387521972									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5110	chr2	170550793	170550813	169694283	169694303	77438	hg19					enhancer	enh				GTACGGTTTGGACGGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				0.15962393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5111	chr2	170550895	170550916	169694385	169694406	77439	hg19					enhancer	enh				GGAGTTGTTACTCGTACCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-1.550211618									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5112	chr2	170550896	170550916	169694386	169694406	77440	hg19					enhancer	enh				GAGTTGTTACTCGTACCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	direct	Highly Significant	NA				0.314641225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5113	chr2	170550914	170550934	169694404	169694424	77441	hg19					enhancer	enh				GGCGTTGCCAAGCAACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.68671927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5114	chr2	170550914	170550936	169694404	169694426	77442	hg19					enhancer	enh				GCGGCGTTGCCAAGCAACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	direct	Highly Significant	NA				0.624247282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5115	chr2	170550946	170550968	169694436	169694458	77443	hg19					enhancer	enh				GCCAGCCGTAGCCGAGGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.03432184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5116	chr2	170550950	170550971	169694440	169694461	77444	hg19					enhancer	enh				GCCGTAGCCGAGGAACAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.08441791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5117	chr2	170550961	170550983	169694451	169694473	77445	hg19					enhancer	enh				GGAACAAGGGAGGTGCTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	direct	Highly Significant	NA				0.326150944									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5118	chr2	170550962	170550983	169694452	169694473	77446	hg19					enhancer	enh				GAACAAGGGAGGTGCTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.113334406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5119	chr2	170551004	170551025	169694494	169694515	77447	hg19					enhancer	enh				GAGGCGCCTGCGCTTGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.80824177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5120	chr2	170551004	170551026	169694494	169694516	77448	hg19					enhancer	enh				GAGGCGCCTGCGCTTGCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.209488063									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5121	chr2	170551006	170551026	169694496	169694516	77449	hg19					enhancer	enh				GGCGCCTGCGCTTGCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				0.189776277									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5122	chr2	170551066	170551088	169694556	169694578	77450	hg19					enhancer	enh				GAGGCCAAAGGACTGAACCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				-0.152659555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5123	chr2	170551068	170551088	169694558	169694578	77451	hg19					enhancer	enh				GGCCAAAGGACTGAACCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	direct	Highly Significant	NA				0.214160488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5124	chr2	170551076	170551098	169694566	169694588	77452	hg19					enhancer	enh				GACTGAACCCGCAGGAGCGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PHOSPHO2	indirect	Non Significant	NA				0.134467463									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5125	chr2	171569014	171569034	170712504	170712524	77453	hg19					enhancer	enh				GTCCAGGAGCTCCGAGGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.055173412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5126	chr2	171569015	171569035	170712505	170712525	77454	hg19					enhancer	enh				GCCAGGAGCTCCGAGGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125074294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5127	chr2	171569016	171569036	170712506	170712526	77455	hg19					enhancer	enh				GCAGGAGCTCCGAGGGCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.438325509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5128	chr2	171569017	171569037	170712507	170712527	77456	hg19					enhancer	enh				GAGGAGCTCCGAGGGCCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.499552352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5129	chr2	171569018	171569038	170712508	170712528	77457	hg19					enhancer	enh				GCCCTTGGCCCTCGGAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.035014626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5130	chr2	171569021	171569041	170712511	170712531	77458	hg19					enhancer	enh				GCTCCGAGGGCCAAGGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.860404057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5131	chr2	171569022	171569042	170712512	170712532	77459	hg19					enhancer	enh				GCTCCGAGGGCCAAGGGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.219682351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5132	chr2	171569027	171569047	170712517	170712537	77460	hg19					enhancer	enh				GCCCCCAACCCCCTTGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.03583873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5133	chr2	171569034	171569054	170712524	170712544	77461	hg19					enhancer	enh				GTTAGTCTCCCCCAACCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.60056032									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5134	chr2	171569070	171569090	170712560	170712580	77462	hg19					enhancer	enh				GCCTCTCTCCAAACTTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177526937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5135	chr2	171569071	171569091	170712561	170712581	77463	hg19					enhancer	enh				GCCTCTCTCCAAACTTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006252571									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5136	chr2	171569072	171569092	170712562	170712582	77464	hg19					enhancer	enh				GCTCTCTCCAAACTTCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324124397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5137	chr2	171569074	171569094	170712564	170712584	77465	hg19					enhancer	enh				GCCCAGCTGAAGTTTGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.447772115									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5138	chr2	171569077	171569097	170712567	170712587	77466	hg19					enhancer	enh				GTCCAAACTTCAGCTGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.053245183									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5139	chr2	171569078	171569098	170712568	170712588	77467	hg19					enhancer	enh				GCCAAACTTCAGCTGGGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.184772845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5140	chr2	171569081	171569101	170712571	170712591	77468	hg19					enhancer	enh				GCCCAGGCCCCAGCTGAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.842056442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5141	chr2	171569081	171569101	170712571	170712591	77469	hg19					enhancer	enh				GAACTTCAGCTGGGGCCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.297560647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5142	chr2	171569097	171569117	170712587	170712607	77470	hg19					enhancer	enh				GTGGGAGGACCGGAATCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.896307249									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5143	chr2	171569098	171569118	170712588	170712608	77471	hg19					enhancer	enh				GGGAGGACCGGAATCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.162026297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5144	chr2	171569098	171569118	170712588	170712608	77472	hg19					enhancer	enh				GTCCAGATTCCGGTCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.241198483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5145	chr2	171569108	171569128	170712598	170712618	77473	hg19					enhancer	enh				GTGAAAACCCGTCCAGATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152365134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5146	chr2	171569145	171569165	170712635	170712655	77474	hg19					enhancer	enh				GTGGTCGCAGTTGGCTGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159604554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5147	chr2	171569153	171569173	170712643	170712663	77475	hg19					enhancer	enh				GCAACTGCGACCACTCAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.468090329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5148	chr2	171569154	171569174	170712644	170712664	77476	hg19					enhancer	enh				GAACTGCGACCACTCAAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.361983867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5149	chr2	171569155	171569175	170712645	170712665	77477	hg19					enhancer	enh				GCTCTCTTGAGTGGTCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121448349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5150	chr2	171569165	171569185	170712655	170712675	77478	hg19					enhancer	enh				GACAGAAGGCCCTCTCTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.643340267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5151	chr2	171569180	171569200	170712670	170712690	77479	hg19					enhancer	enh				GACGGTGCTGAGCGTACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.991728365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5152	chr2	171569198	171569218	170712688	170712708	77480	hg19					enhancer	enh				GTATACGCAAGGTCTTTAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229452969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5153	chr2	171569210	171569230	170712700	170712720	77481	hg19					enhancer	enh				GTTTAAGAGTTAATATACGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.133947608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5154	chr2	171569227	171569247	170712717	170712737	77482	hg19					enhancer	enh				GAAACCTATAGCCACTCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.246522208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5155	chr2	171569228	171569248	170712718	170712738	77483	hg19					enhancer	enh				GAACCTATAGCCACTCTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.734149936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5156	chr2	171569229	171569249	170712719	170712739	77484	hg19					enhancer	enh				GACCTATAGCCACTCTACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.300967808									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5157	chr2	171569233	171569253	170712723	170712743	77485	hg19					enhancer	enh				GACCCCTTGTAGAGTGGCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320940739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5158	chr2	171569240	171569260	170712730	170712750	77486	hg19					enhancer	enh				GATAGTGCACCCCTTGTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.288020268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5159	chr2	171569281	171569301	170712771	170712791	77487	hg19					enhancer	enh				GCGCAAAACTGAGGTACACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.262453388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5160	chr2	171569303	171569323	170712793	170712813	77488	hg19					enhancer	enh				GCTGAGTACCTTGCTTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198853381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5161	chr2	171569314	171569334	170712804	170712824	77489	hg19					enhancer	enh				GTTGGTGACCTTGGCAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121968465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5162	chr2	171569321	171569341	170712811	170712831	77490	hg19					enhancer	enh				GCAAGGTCACCAACTAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229706601									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5163	chr2	171569326	171569346	170712816	170712836	77491	hg19					enhancer	enh				GTCACCAACTAGAAAGTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.036676157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5164	chr2	171569329	171569349	170712819	170712839	77492	hg19					enhancer	enh				GCCAACTAGAAAGTGGCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.565662235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5165	chr2	171569332	171569352	170712822	170712842	77493	hg19					enhancer	enh				GCCGCCTTGCCACTTTCTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253177677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5166	chr2	171569353	171569373	170712843	170712863	77494	hg19					enhancer	enh				GAAAAATGTCTTCAGAGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055662189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5167	chr2	171569382	171569402	170712872	170712892	77495	hg19					enhancer	enh				GTGGCTTGGTGGTTGAAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.599549569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5168	chr2	171569394	171569414	170712884	170712904	77496	hg19					enhancer	enh				GGTCAAAGTTAGTGGCTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.773034855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5169	chr2	171569397	171569417	170712887	170712907	77497	hg19					enhancer	enh				GCAGGGTCAAAGTTAGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.255277786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5170	chr2	171569398	171569418	170712888	170712908	77498	hg19					enhancer	enh				GCCACTAACTTTGACCCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050959409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5171	chr2	171569402	171569422	170712892	170712912	77499	hg19					enhancer	enh				GCCAACAGGGTCAAAGTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084765683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5172	chr2	171569409	171569429	170712899	170712919	77500	hg19					enhancer	enh				GTGACCCTGTTGGCCCACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.514362341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5173	chr2	171569415	171569435	170712905	170712925	77501	hg19					enhancer	enh				GAAACCATCAGTGGGCCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.600231129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5174	chr2	171569416	171569436	170712906	170712926	77502	hg19					enhancer	enh				GTAAACCATCAGTGGGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.47623166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5175	chr2	171569418	171569438	170712908	170712928	77503	hg19					enhancer	enh				GTGGCCCACTGATGGTTTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.21424687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5176	chr2	171569424	171569444	170712914	170712934	77504	hg19					enhancer	enh				GTAGCCAGTTAAACCATCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.347182004									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5177	chr2	171569425	171569445	170712915	170712935	77505	hg19					enhancer	enh				GCTGATGGTTTAACTGGCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.520500871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5178	chr2	171569425	171569445	170712915	170712935	77506	hg19					enhancer	enh				GTTAGCCAGTTAAACCATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.129396211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5179	chr2	171569427	171569447	170712917	170712937	77507	hg19					enhancer	enh				GATGGTTTAACTGGCTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.426115397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5180	chr2	171569428	171569448	170712918	170712938	77508	hg19					enhancer	enh				GATGGTTTAACTGGCTAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.231348294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5181	chr2	171569436	171569456	170712926	170712946	77509	hg19					enhancer	enh				GACTGGCTAATGGGGGCATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.804507275									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5182	chr2	171569463	171569483	170712953	170712973	77510	hg19					enhancer	enh				GAAAGCTAATTCCCATAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.742961332									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5183	chr2	171569464	171569484	170712954	170712974	77511	hg19					enhancer	enh				GAAGCTAATTCCCATAACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.290946614									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5184	chr2	171569465	171569485	170712955	170712975	77512	hg19					enhancer	enh				GAGCTAATTCCCATAACTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.759073611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5185	chr2	171569476	171569496	170712966	170712986	77513	hg19					enhancer	enh				GATAACTATGGGGATGTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.498367281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5186	chr2	171569477	171569497	170712967	170712987	77514	hg19					enhancer	enh				GATTTCACATCCCCATAGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.022320421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5187	chr2	171569511	171569531	170713001	170713021	77515	hg19					enhancer	enh				GTGATAGCTACTTTCCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273304025									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5188	chr2	171569523	171569543	170713013	170713033	77516	hg19					enhancer	enh				GAGCTATCAGATTCAATAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.330400374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5189	chr2	171569524	171569544	170713014	170713034	77517	hg19					enhancer	enh				GCTATCAGATTCAATAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048963201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5190	chr2	171569549	171569569	170713039	170713059	77518	hg19					enhancer	enh				GCCTTCCATCCTGCTTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157961184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5191	chr2	171569553	171569573	170713043	170713063	77519	hg19					enhancer	enh				GCCGGGCTAAGCAGGATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.569612182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5192	chr2	171569557	171569577	170713047	170713067	77520	hg19					enhancer	enh				GCAGGGCCGGGCTAAGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07848406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5193	chr2	171569568	171569588	170713058	170713078	77521	hg19					enhancer	enh				GCCGGCCCTGCCCGCCTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.274606287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5194	chr2	171569573	171569593	170713063	170713083	77522	hg19					enhancer	enh				GCCTGCCCGCCTCCCTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107016437									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5195	chr2	171569574	171569594	170713064	170713084	77523	hg19					enhancer	enh				GCTGCCCGCCTCCCTGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.254157509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5196	chr2	171569575	171569595	170713065	170713085	77524	hg19					enhancer	enh				GCTTTCCCAGGGAGGCGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328849725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5197	chr2	171569575	171569595	170713065	170713085	77525	hg19					enhancer	enh				GTGCCCGCCTCCCTGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.386463594									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5198	chr2	171569576	171569596	170713066	170713086	77526	hg19					enhancer	enh				GCCTTTCCCAGGGAGGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.178649333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5199	chr2	171569581	171569601	170713071	170713091	77527	hg19					enhancer	enh				GAGTCCCCTTTCCCAGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161165187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5200	chr2	171569584	171569604	170713074	170713094	77528	hg19					enhancer	enh				GCGAAGTCCCCTTTCCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.503251023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5201	chr2	171569587	171569607	170713077	170713097	77529	hg19					enhancer	enh				GCTTCGAAGTCCCCTTTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204138148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5202	chr2	171569588	171569608	170713078	170713098	77530	hg19					enhancer	enh				GTCTTCGAAGTCCCCTTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047189215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5203	chr2	171569600	171569620	170713090	170713110	77531	hg19					enhancer	enh				GTTCGAAGATCTCAAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324128291									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5204	chr2	171569605	171569625	170713095	170713115	77532	hg19					enhancer	enh				GAGATCTCAAAGAAGCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.435913934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5205	chr2	171569620	171569640	170713110	170713130	77533	hg19					enhancer	enh				GTGGAAAGGAAACCAGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009864796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5206	chr2	171569634	171569654	170713124	170713144	77534	hg19					enhancer	enh				GCGATCTGGTTCCTTAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.609168477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5207	chr2	171569638	171569658	170713128	170713148	77535	hg19					enhancer	enh				GTAAGGAACCAGATCGCTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.082216069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5208	chr2	171569639	171569659	170713129	170713149	77536	hg19					enhancer	enh				GAAGGAACCAGATCGCTTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.289234395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5209	chr2	171569648	171569668	170713138	170713158	77537	hg19					enhancer	enh				GCTTGCACCCTCGAAGCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.273775105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5210	chr2	171569655	171569675	170713145	170713165	77538	hg19					enhancer	enh				GTCGAGGGTGCAAGCATGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217161167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5211	chr2	171569673	171569693	170713163	170713183	77539	hg19					enhancer	enh				GCAGGCGCGAGTGTGTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253204943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5212	chr2	171569674	171569694	170713164	170713184	77540	hg19					enhancer	enh				GCAGGCGCGAGTGTGTGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.008411046									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5213	chr2	171569675	171569695	170713165	170713185	77541	hg19					enhancer	enh				GAGGCGCGAGTGTGTGCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.231268623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5214	chr2	171569683	171569703	170713173	170713193	77542	hg19					enhancer	enh				GTGTGTGCCAAGGGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227539778									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5215	chr2	171569693	171569713	170713183	170713203	77543	hg19					enhancer	enh				GTCGGAGGCCAGGGAGCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.659580733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5216	chr2	171569702	171569722	170713192	170713212	77544	hg19					enhancer	enh				GCTGGCCTCCGACTTGCATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156153057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5217	chr2	171569703	171569723	170713193	170713213	77545	hg19					enhancer	enh				GTGGATGCAAGTCGGAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.077949607									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5218	chr2	171569703	171569723	170713193	170713213	77546	hg19					enhancer	enh				GTGGCCTCCGACTTGCATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.00716511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5219	chr2	171569704	171569724	170713194	170713214	77547	hg19					enhancer	enh				GCTGGATGCAAGTCGGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.302820904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5220	chr2	171569709	171569729	170713199	170713219	77548	hg19					enhancer	enh				GCTTCCCTGGATGCAAGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.149389512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5221	chr2	171569712	171569732	170713202	170713222	77549	hg19					enhancer	enh				GCTCTTCCCTGGATGCAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099215471									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5222	chr2	171569723	171569743	170713213	170713233	77550	hg19					enhancer	enh				GACTCGAGGGAGCTCTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373060868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5223	chr2	171569736	171569756	170713226	170713246	77551	hg19					enhancer	enh				GTGGAGAAGCGTGAGACTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.028602842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5224	chr2	171569737	171569757	170713227	170713247	77552	hg19					enhancer	enh				GTTGGAGAAGCGTGAGACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.701150695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5225	chr2	171569748	171569768	170713238	170713258	77553	hg19					enhancer	enh				GCTTCTCCAAGACTCAAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.22616732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5226	chr2	171569752	171569772	170713242	170713262	77554	hg19					enhancer	enh				GTCCAAGACTCAAATCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.350712543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5227	chr2	171569753	171569773	170713243	170713263	77555	hg19					enhancer	enh				GCCAAGACTCAAATCCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.436191019									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5228	chr2	171569756	171569776	170713246	170713266	77556	hg19					enhancer	enh				GCCCGTCCAGGATTTGAGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.218980476									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5229	chr2	171569760	171569780	170713250	170713270	77557	hg19					enhancer	enh				GTCAAATCCTGGACGGGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.625290354									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5230	chr2	171569761	171569781	170713251	170713271	77558	hg19					enhancer	enh				GCAAATCCTGGACGGGAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.266287745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5231	chr2	171569769	171569789	170713259	170713279	77559	hg19					enhancer	enh				GTCCTTCCCACGCTCCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.392370608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5232	chr2	171569786	171569806	170713276	170713296	77560	hg19					enhancer	enh				GGAGCAGGTTGGCCAGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.323350124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5233	chr2	171569801	171569821	170713291	170713311	77561	hg19					enhancer	enh				GTAGTGGTTTCATCCGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.563460452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5234	chr2	171569806	171569826	170713296	170713316	77562	hg19					enhancer	enh				GAGCTTAGTGGTTTCATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.024026733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5235	chr2	171569818	171569838	170713308	170713328	77563	hg19					enhancer	enh				GAGAAGGGGAGAGAGCTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.258924702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5236	chr2	171569832	171569852	170713322	170713342	77564	hg19					enhancer	enh				GCTGCTCTGGGAGCGGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.107382389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5237	chr2	171569833	171569853	170713323	170713343	77565	hg19					enhancer	enh				GCTGCTCTGGGAGCGGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.313839891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5238	chr2	171569834	171569854	170713324	170713344	77566	hg19					enhancer	enh				GGCTGCTCTGGGAGCGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.245452674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5239	chr2	171569840	171569860	170713330	170713350	77567	hg19					enhancer	enh				GAGGTCGGCTGCTCTGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305040849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5240	chr2	171569845	171569865	170713335	170713355	77568	hg19					enhancer	enh				GAAGATGAGGTCGGCTGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.489441785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5241	chr2	171569846	171569866	170713336	170713356	77569	hg19					enhancer	enh				GAAGATGAGGTCGGCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.526701989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5242	chr2	171569855	171569875	170713345	170713365	77570	hg19					enhancer	enh				GCTGGCTTCTGAAGATGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.152573908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5243	chr2	171569857	171569877	170713347	170713367	77571	hg19					enhancer	enh				GCTCATCTTCAGAAGCCAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.482397242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5244	chr2	171569858	171569878	170713348	170713368	77572	hg19					enhancer	enh				GTCATCTTCAGAAGCCAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.435064985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5245	chr2	171569859	171569879	170713349	170713369	77573	hg19					enhancer	enh				GCGATCTGGCTTCTGAAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.095210886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5246	chr2	171569862	171569882	170713352	170713372	77574	hg19					enhancer	enh				GCTTCAGAAGCCAGATCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.053992868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5247	chr2	171569874	171569894	170713364	170713384	77575	hg19					enhancer	enh				GACAACTTGGCCGACCCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.537456792									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5248	chr2	171569875	171569895	170713365	170713385	77576	hg19					enhancer	enh				GATCGGGTCGGCCAAGTTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.127815389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5249	chr2	171569888	171569908	170713378	170713398	77577	hg19					enhancer	enh				GCGAGCGGCGACCACACAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.460248731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5250	chr2	171569904	171569924	170713394	170713414	77578	hg19					enhancer	enh				GTGTCCCCTCTAAAACGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145619632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5251	chr2	171569911	171569931	170713401	170713421	77579	hg19					enhancer	enh				GTTTAGAGGGGACAACTCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.574193814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5252	chr2	171569912	171569932	170713402	170713422	77580	hg19					enhancer	enh				GTTAGAGGGGACAACTCGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201681182									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5253	chr2	171569913	171569933	170713403	170713423	77581	hg19					enhancer	enh				GTAGAGGGGACAACTCGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014048775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5254	chr2	171569919	171569939	170713409	170713429	77582	hg19					enhancer	enh				GGACAACTCGTTGGGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.471423468									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5255	chr2	171569920	171569940	170713410	170713430	77583	hg19					enhancer	enh				GACAACTCGTTGGGGGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.163896308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5256	chr2	171569921	171569941	170713411	170713431	77584	hg19					enhancer	enh				GACAACTCGTTGGGGGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.057554045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5257	chr2	171569922	171569942	170713412	170713432	77585	hg19					enhancer	enh				GCAACTCGTTGGGGGAGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.173127828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5258	chr2	171569946	171569966	170713436	170713456	77586	hg19					enhancer	enh				GTGCGAGTGCAGGATGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.400822565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5259	chr2	171569947	171569967	170713437	170713457	77587	hg19					enhancer	enh				GTGCGAGTGCAGGATGTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040435065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5260	chr2	171569962	171569982	170713452	170713472	77588	hg19					enhancer	enh				GTGCGAGGGACCCATTGTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.941359679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5261	chr2	171569963	171569983	170713453	170713473	77589	hg19					enhancer	enh				GCGAGGGACCCATTGTATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.082326345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5262	chr2	171569974	171569994	170713464	170713484	77590	hg19					enhancer	enh				GCTTGCGACCCAAATACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.287934065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5263	chr2	171569975	171569995	170713465	170713485	77591	hg19					enhancer	enh				GTGCTTGCGACCCAAATACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274001201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5264	chr2	171569999	171570019	170713489	170713509	77592	hg19					enhancer	enh				GATATCGTACTCAAGACGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.166643064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5265	chr2	171570000	171570020	170713490	170713510	77593	hg19					enhancer	enh				GAATATCGTACTCAAGACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.532081323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5266	chr2	171570003	171570023	170713493	170713513	77594	hg19					enhancer	enh				GAGAATATCGTACTCAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084523017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5267	chr2	171570004	171570024	170713494	170713514	77595	hg19					enhancer	enh				GTGAGAATATCGTACTCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262113735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5268	chr2	171570010	171570030	170713500	170713520	77596	hg19					enhancer	enh				GTACGATATTCTCATTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.86452136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5269	chr2	171570020	171570040	170713510	170713530	77597	hg19					enhancer	enh				GCTCATTCCGCAGGCGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.146749557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5270	chr2	171570021	171570041	170713511	170713531	77598	hg19					enhancer	enh				GTCATTCCGCAGGCGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.109307982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5271	chr2	171570026	171570046	170713516	170713536	77599	hg19					enhancer	enh				GCCGCAGGCGCGCCCTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.276273113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5272	chr2	171570027	171570047	170713517	170713537	77600	hg19					enhancer	enh				GCGCAGGCGCGCCCTGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275035053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5273	chr2	171570029	171570049	170713519	170713539	77601	hg19					enhancer	enh				GCCACGCCCAGGGCGCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.68972665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5274	chr2	171570040	171570060	170713530	170713550	77602	hg19					enhancer	enh				GCCCACCTTCTCCCACGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.278095292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5275	chr2	171570041	171570061	170713531	170713551	77603	hg19					enhancer	enh				GCCCACCTTCTCCCACGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.252322154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5276	chr2	171570063	171570083	170713553	170713573	77604	hg19					enhancer	enh				GTCGGGGATGCGATGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178231408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5277	chr2	171570064	171570084	170713554	170713574	77605	hg19					enhancer	enh				GGTCGGGGATGCGATGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024860457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5278	chr2	171570069	171570089	170713559	170713579	77606	hg19					enhancer	enh				GATCGCATCCCCGACCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.000937868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5279	chr2	171570079	171570099	170713569	170713589	77607	hg19					enhancer	enh				GCGCACTTCCATCAGGGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026059736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5280	chr2	171570080	171570100	170713570	170713590	77608	hg19					enhancer	enh				GACCCCTGATGGAAGTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.137653335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5281	chr2	171570080	171570100	170713570	170713590	77609	hg19					enhancer	enh				GCCGCACTTCCATCAGGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.340462773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5282	chr2	171570081	171570101	170713571	170713591	77610	hg19					enhancer	enh				GTCCGCACTTCCATCAGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200259852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5283	chr2	171570081	171570101	170713571	170713591	77611	hg19					enhancer	enh				GACCCCTGATGGAAGTGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178923829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5284	chr2	171570085	171570105	170713575	170713595	77612	hg19					enhancer	enh				GCCCTCCGCACTTCCATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.527653948									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5285	chr2	171570086	171570106	170713576	170713596	77613	hg19					enhancer	enh				GTGCCCTCCGCACTTCCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.025675098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5286	chr2	171570087	171570107	170713577	170713597	77614	hg19					enhancer	enh				GATGCCCTCCGCACTTCCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070989829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5287	chr2	171570110	171570130	170713600	170713620	77615	hg19					enhancer	enh				GCTCGGAATCTGGACTGTATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11939507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5288	chr2	171570121	171570141	170713611	170713631	77616	hg19					enhancer	enh				GACTACAACGGACTCGGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.300506178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5289	chr2	171570128	171570148	170713618	170713638	77617	hg19					enhancer	enh				GTAGCCTAACTACAACGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.069168536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5290	chr2	171570134	171570154	170713624	170713644	77618	hg19					enhancer	enh				GAGAGGTTAGCCTAACTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.87407268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5291	chr2	171570144	171570164	170713634	170713654	77619	hg19					enhancer	enh				GCTAACCTCTGACGCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208272966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5292	chr2	171570145	171570165	170713635	170713655	77620	hg19					enhancer	enh				GCTAACCTCTGACGCTGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048794603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5293	chr2	171570152	171570172	170713642	170713662	77621	hg19					enhancer	enh				GCTGACGCTGCATCGGGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.140041045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5294	chr2	171570152	171570172	170713642	170713662	77622	hg19					enhancer	enh				GATCTCCCGATGCAGCGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305444946									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5295	chr2	171570170	171570190	170713660	170713680	77623	hg19					enhancer	enh				GATAGGTCACCCCGTCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.051554887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5296	chr2	171570181	171570201	170713671	170713691	77624	hg19					enhancer	enh				GCACTGCGACCGGGACGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.317923741									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5297	chr2	171570181	171570201	170713671	170713691	77625	hg19					enhancer	enh				GCGTCCGTCCCGGTCGCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.430489745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5298	chr2	171570182	171570202	170713672	170713692	77626	hg19					enhancer	enh				GCACTGCGACCGGGACGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.414137134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5299	chr2	171570183	171570203	170713673	170713693	77627	hg19					enhancer	enh				GCGCACTGCGACCGGGACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.106174135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5300	chr2	171570187	171570207	170713677	170713697	77628	hg19					enhancer	enh				GAACCGCACTGCGACCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169999679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5301	chr2	171570191	171570211	170713681	170713701	77629	hg19					enhancer	enh				GACGGGAACCGCACTGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.659998877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5302	chr2	171570192	171570212	170713682	170713702	77630	hg19					enhancer	enh				GTCGCAGTGCGGTTCCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198435588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5303	chr2	171570192	171570212	170713682	170713702	77631	hg19					enhancer	enh				GCACGGGAACCGCACTGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.822633167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5304	chr2	171570199	171570219	170713689	170713709	77632	hg19					enhancer	enh				GTGCGGTTCCCGTGAGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.117564809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5305	chr2	171570200	171570220	170713690	170713710	77633	hg19					enhancer	enh				GCGGTTCCCGTGAGGAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.016983278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5306	chr2	171570209	171570229	170713699	170713719	77634	hg19					enhancer	enh				GTCTCTGCCCGTCTTCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049784909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5307	chr2	171570210	171570230	170713700	170713720	77635	hg19					enhancer	enh				GCTCTCTGCCCGTCTTCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.037114721									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5308	chr2	171570228	171570248	170713718	170713738	77636	hg19					enhancer	enh				GAGGCCGGGCGCGAACTGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.412068337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5309	chr2	171570229	171570249	170713719	170713739	77637	hg19					enhancer	enh				GGCCGGGCGCGAACTGATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221606625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5310	chr2	171570230	171570250	170713720	170713740	77638	hg19					enhancer	enh				GCCGGGCGCGAACTGATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.915973178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5311	chr2	171570234	171570254	170713724	170713744	77639	hg19					enhancer	enh				GCCCCTAATCAGTTCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274072848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5312	chr2	171570241	171570261	170713731	170713751	77640	hg19					enhancer	enh				GACTGATTAGGGGCTCCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.854086547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5313	chr2	171570245	171570265	170713735	170713755	77641	hg19					enhancer	enh				GATTAGGGGCTCCCCCACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.011432579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5314	chr2	171570248	171570268	170713738	170713758	77642	hg19					enhancer	enh				GAGGGGCTCCCCCACGGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223968294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5315	chr2	171570253	171570273	170713743	170713763	77643	hg19					enhancer	enh				GCTCCCCCACGGCCGGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078680359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5316	chr2	171570258	171570278	170713748	170713768	77644	hg19					enhancer	enh				GCTCCAGGCCGCCGGCCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019429472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5317	chr2	171570259	171570279	170713749	170713769	77645	hg19					enhancer	enh				GTCTCCAGGCCGCCGGCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.347937844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5318	chr2	171570260	171570280	170713750	170713770	77646	hg19					enhancer	enh				GCTCTCCAGGCCGCCGGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.127739953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5319	chr2	171570261	171570281	170713751	170713771	77647	hg19					enhancer	enh				GACTCTCCAGGCCGCCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.12690602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5320	chr2	171570267	171570287	170713757	170713777	77648	hg19					enhancer	enh				GTCTCCACTCTCCAGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.12608485									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5321	chr2	171570274	171570294	170713764	170713784	77649	hg19					enhancer	enh				GGACACAGTCTCCACTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.114999516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5322	chr2	171570276	171570296	170713766	170713786	77650	hg19					enhancer	enh				GAGAGTGGAGACTGTGTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.403507139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5323	chr2	171570277	171570297	170713767	170713787	77651	hg19					enhancer	enh				GAGTGGAGACTGTGTCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.538100425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5324	chr2	171570280	171570300	170713770	170713790	77652	hg19					enhancer	enh				GTGGAGACTGTGTCCGACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.166530898									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5325	chr2	171570283	171570303	170713773	170713793	77653	hg19					enhancer	enh				GAGACTGTGTCCGACGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.821656523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5326	chr2	171570284	171570304	170713774	170713794	77654	hg19					enhancer	enh				GACTGTGTCCGACGGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.605198606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5327	chr2	171570295	171570315	170713785	170713805	77655	hg19					enhancer	enh				GCTCCCCCACCCACCTCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032238559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96895	chr2	171570312	171570332	170713802	170713822	77656	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GAGAGGAGTAGGCCGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.086846048	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570315	171570335	170713805	170713825	77657	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GAGGAGTAGGCCGAGCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324720808	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570327	171570347	170713817	170713837	77658	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGGAGTGGCCGCCGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.41318972	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570334	171570354	170713824	170713844	77659	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCACTGCGGAGTGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.393578018	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570341	171570361	170713831	170713851	77660	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCGAGAGCGCACTGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09903235	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570344	171570364	170713834	170713854	77661	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCAGTGCGCTCTCGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.060593616	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570345	171570365	170713835	170713855	77662	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCAGTGCGCTCTCGCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.129505603	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570346	171570366	170713836	170713856	77663	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCAGTGCGCTCTCGCGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233655517	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570346	171570366	170713836	170713856	77664	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGGCTCGCGAGAGCGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.268707454	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570354	171570374	170713844	170713864	77665	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTCTCGCGAGCCGGGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157531142	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570366	171570386	170713856	170713876	77666	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GGGCCGCGAGGCCTCCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090916335	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570366	171570386	170713856	170713876	77667	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGTTGGAGGCCTCGCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086619498	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570372	171570392	170713862	170713882	77668	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GAACCGCGTTGGAGGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084432115	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570383	171570403	170713873	170713893	77669	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTTAGGGGTGCGGAACCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262837735	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570389	171570409	170713879	170713899	77670	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTTCCGCACCCCTAATGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.129981366	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570390	171570410	170713880	170713900	77671	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTCCGCACCCCTAATGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033214155	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570393	171570413	170713883	170713903	77672	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCACCCCTAATGCCCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.198201873	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570394	171570414	170713884	170713904	77673	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCCTGGGGCATTAGGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.576470719	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570399	171570419	170713889	170713909	77674	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTCACCGCCCTGGGGCATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173791375	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570400	171570420	170713890	170713910	77675	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCTCACCGCCCTGGGGCATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.585505662	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570401	171570421	170713891	170713911	77676	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCTCACCGCCCTGGGGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.572630832	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570407	171570427	170713897	170713917	77677	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCAGGGCGGTGAGCACCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15813802	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570408	171570428	170713898	170713918	77678	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGGGGTGCTCACCGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078341356	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570409	171570429	170713899	170713919	77679	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCGGGGTGCTCACCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081777939	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570410	171570430	170713900	170713920	77680	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCGCGGGGTGCTCACCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055079034	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570449	171570469	170713939	170713959	77681	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTCCTTCCCCGCCCGCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.241563616	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570455	171570475	170713945	170713965	77682	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCCGCCCGCGCGCCCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005864143	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570457	171570477	170713947	170713967	77683	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCTCTCCCGGGCGCGCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062300949	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570458	171570478	170713948	170713968	77684	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCTCTCCCGGGCGCGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.179017585	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570459	171570479	170713949	170713969	77685	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCTCTCCCGGGCGCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153316558	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570462	171570482	170713952	170713972	77686	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GATCGCCTCTCCCGGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.338398443	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570463	171570483	170713953	170713973	77687	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GATCGCCTCTCCCGGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.304676717	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570470	171570490	170713960	170713980	77688	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GACGCGGGGATCGCCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.242610219	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570471	171570491	170713961	170713981	77689	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GACGCGGGGATCGCCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.069401034	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570479	171570499	170713969	170713989	77690	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GATCCCCGCGTCCGCAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371058009	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570480	171570500	170713970	170713990	77691	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GATCCCCGCGTCCGCAGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.074973767	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570481	171570501	170713971	170713991	77692	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTCCCCGCGTCCGCAGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252346324	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570485	171570505	170713975	170713995	77693	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCCCCGGCACTGCGGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.351986055	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570485	171570505	170713975	170713995	77694	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCGTCCGCAGTGCCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.403234978	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570486	171570506	170713976	170713996	77695	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GTGCCCCGGCACTGCGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217658664	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570487	171570507	170713977	170713997	77696	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCTGCCCCGGCACTGCGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.37507164	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570493	171570513	170713983	170714003	77697	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCGTCCTGCCCCGGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.086465761	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570501	171570521	170713991	170714011	77698	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCGCAGGGCGCGTCCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324732405	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570503	171570523	170713993	170714013	77699	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCAGGACGCGCCCTGCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217574007	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-96895	chr2	171570504	171570524	170713994	170714014	77700	hg19	N/A	N/A	fant9228	N/A	enhancer	enh				GCAGGACGCGCCCTGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.087606767	SP5	chr2	170715336	170718078	1340				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8821
enhrx-lit5328	chr2	171570516	171570536	170714006	170714026	77701	hg19					enhancer	enh				GTCCTCCTGGCCCAGGGCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.420963518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5329	chr2	171570517	171570537	170714007	170714027	77702	hg19					enhancer	enh				GCTCCTCCTGGCCCAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224174399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5330	chr2	171570523	171570543	170714013	170714033	77703	hg19					enhancer	enh				GACCTGCCTCCTCCTGGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.052445894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5331	chr2	171570530	171570550	170714020	170714040	77704	hg19					enhancer	enh				GAGGGCCACCTGCCTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.430362684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5332	chr2	171570532	171570552	170714022	170714042	77705	hg19					enhancer	enh				GAGGAGGCAGGTGGCCCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127795991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5333	chr2	171570536	171570556	170714026	170714046	77706	hg19					enhancer	enh				GGCAGGTGGCCCTCCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06739977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5334	chr2	171570539	171570559	170714029	170714049	77707	hg19					enhancer	enh				GAGGTGGCCCTCCTCGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.174933287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5335	chr2	171570548	171570568	170714038	170714058	77708	hg19					enhancer	enh				GGCTCACCTCCTGCCGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025770647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5336	chr2	171570549	171570569	170714039	170714059	77709	hg19					enhancer	enh				GCGGCTCACCTCCTGCCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173655699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5337	chr2	171570551	171570571	170714041	170714061	77710	hg19					enhancer	enh				GTCGGCAGGAGGTGAGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061158684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5338	chr2	171570552	171570572	170714042	170714062	77711	hg19					enhancer	enh				GTGGCGGCTCACCTCCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217845543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5339	chr2	171570552	171570572	170714042	170714062	77712	hg19					enhancer	enh				GCGGCAGGAGGTGAGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.240576875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5340	chr2	171570561	171570581	170714051	170714071	77713	hg19					enhancer	enh				GTGAGCCGCCAGGGAGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.352971347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5341	chr2	171570569	171570589	170714059	170714079	77714	hg19					enhancer	enh				GTGACCCCCATCCCTCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.497739964									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5342	chr2	171570572	171570592	170714062	170714082	77715	hg19					enhancer	enh				GGGTGACCCCCATCCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.226196718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5343	chr2	171570592	171570612	170714082	170714102	77716	hg19					enhancer	enh				GGTCGCGCTTGCAGGGGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.385841458									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5344	chr2	171570593	171570613	170714083	170714103	77717	hg19					enhancer	enh				GGGTCGCGCTTGCAGGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.465947562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5345	chr2	171570598	171570618	170714088	170714108	77718	hg19					enhancer	enh				GGGCAGGGTCGCGCTTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0221795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5346	chr2	171570599	171570619	170714089	170714109	77719	hg19					enhancer	enh				GTGGGCAGGGTCGCGCTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.671623766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5347	chr2	171570600	171570620	170714090	170714110	77720	hg19					enhancer	enh				GCTGGGCAGGGTCGCGCTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208764139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5348	chr2	171570613	171570633	170714103	170714123	77721	hg19					enhancer	enh				GGCGTGCTTTGCTCTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.281853528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5349	chr2	171570614	171570634	170714104	170714124	77722	hg19					enhancer	enh				GGGCGTGCTTTGCTCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.384005617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5350	chr2	171570618	171570638	170714108	170714128	77723	hg19					enhancer	enh				GCGCGGGGCGTGCTTTGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04415511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5351	chr2	171570619	171570639	170714109	170714129	77724	hg19					enhancer	enh				GCGCGGGGCGTGCTTTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02272218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5352	chr2	171570620	171570640	170714110	170714130	77725	hg19					enhancer	enh				GAGCAAAGCACGCCCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280544081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5353	chr2	171570625	171570645	170714115	170714135	77726	hg19					enhancer	enh				GAGCACGCCCCGCGCCTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.162168998									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5354	chr2	171570634	171570654	170714124	170714144	77727	hg19					enhancer	enh				GAAAGTTCCTCACCAGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.234805238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5355	chr2	171570635	171570655	170714125	170714145	77728	hg19					enhancer	enh				GAAAAGTTCCTCACCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.128576688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5356	chr2	171570636	171570656	170714126	170714146	77729	hg19					enhancer	enh				GAAAAAGTTCCTCACCAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.619818384									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5357	chr2	171570641	171570661	170714131	170714151	77730	hg19					enhancer	enh				GAAAGAAAAAGTTCCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.297281482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5358	chr2	171570663	171570683	170714153	170714173	77731	hg19					enhancer	enh				GAGACTTGTTCCTGCCACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.111910498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5359	chr2	171570700	171570720	170714190	170714210	77732	hg19					enhancer	enh				GCGAGAGAGGATCCCGAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.015846136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5360	chr2	171570701	171570721	170714191	170714211	77733	hg19					enhancer	enh				GACGAGAGAGGATCCCGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.372528701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5361	chr2	171570704	171570724	170714194	170714214	77734	hg19					enhancer	enh				GCATACGAGAGAGGATCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.618198576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5362	chr2	171570714	171570734	170714204	170714224	77735	hg19					enhancer	enh				GAACCACAAATCATACGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.141611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5363	chr2	171570732	171570752	170714222	170714242	77736	hg19					enhancer	enh				GTTTGTGGGACCACAACAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.437093527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5364	chr2	171570744	171570764	170714234	170714254	77737	hg19					enhancer	enh				GTCGAGGAAGCCTGGTTGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239570375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5365	chr2	171570753	171570773	170714243	170714263	77738	hg19					enhancer	enh				GAAGGCGCGGTCGAGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.634958965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5366	chr2	171570761	171570781	170714251	170714271	77739	hg19					enhancer	enh				GCTGGAAAAAAGGCGCGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.430135661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5367	chr2	171570767	171570787	170714257	170714277	77740	hg19					enhancer	enh				GAGCTACTGGAAAAAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.479493141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5368	chr2	171570772	171570792	170714262	170714282	77741	hg19					enhancer	enh				GACCAGGAGCTACTGGAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.454179347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5369	chr2	171570777	171570797	170714267	170714287	77742	hg19					enhancer	enh				GCCAGTAGCTCCTGGTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.193018586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5370	chr2	171570780	171570800	170714270	170714290	77743	hg19					enhancer	enh				GCCTGGCAGACCAGGAGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.500311917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5371	chr2	171570788	171570808	170714278	170714298	77744	hg19					enhancer	enh				GTGGTCTGCCAGGCTTGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.12131284									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5372	chr2	171570789	171570809	170714279	170714299	77745	hg19					enhancer	enh				GGTCTGCCAGGCTTGCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.090489908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5373	chr2	171570789	171570809	170714279	170714299	77746	hg19					enhancer	enh				GTCTCGCAAGCCTGGCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167296048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5374	chr2	171570798	171570818	170714288	170714308	77747	hg19					enhancer	enh				GAGCGCGCCCTCTCGCAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.249967146									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5375	chr2	171570813	171570833	170714303	170714323	77748	hg19					enhancer	enh				GCGCTGGCTTGGCGGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.161100619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5376	chr2	171570814	171570834	170714304	170714324	77749	hg19					enhancer	enh				GCGCTGGCTTGGCGGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.53245185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5377	chr2	171570837	171570857	170714327	170714347	77750	hg19					enhancer	enh				GCGAGAAATCACCAGCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086430203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5378	chr2	171570838	171570858	170714328	170714348	77751	hg19					enhancer	enh				GAGAAATCACCAGCAGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.612539158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5379	chr2	171570839	171570859	170714329	170714349	77752	hg19					enhancer	enh				GAGAAATCACCAGCAGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.978773992									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5380	chr2	171570846	171570866	170714336	170714356	77753	hg19					enhancer	enh				GACCAGCAGCGCTGGGGCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148051109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5381	chr2	171570850	171570870	170714340	170714360	77754	hg19					enhancer	enh				GCCGAAAGCCCCAGCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.650031091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5382	chr2	171570875	171570895	170714365	170714385	77755	hg19					enhancer	enh				GACAGCCCAGCCCGGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092963226									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5383	chr2	171570879	171570899	170714369	170714389	77756	hg19					enhancer	enh				GCCCAGCCCGGGCCTCCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416623055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5384	chr2	171570882	171570902	170714372	170714392	77757	hg19					enhancer	enh				GCCACCCAGGAGGCCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327265368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5385	chr2	171570885	171570905	170714375	170714395	77758	hg19					enhancer	enh				GCCGGGCCTCCTGGGTGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.049910965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5386	chr2	171570886	171570906	170714376	170714396	77759	hg19					enhancer	enh				GCGGGCCTCCTGGGTGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.026673846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5387	chr2	171570893	171570913	170714383	170714403	77760	hg19					enhancer	enh				GTTCTCCCCAGGCCACCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.568784253									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5388	chr2	171570922	171570942	170714412	170714432	77761	hg19					enhancer	enh				GACAGCACAGCTTCTTCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.491870422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5389	chr2	171570923	171570943	170714413	170714433	77762	hg19					enhancer	enh				GCAGCACAGCTTCTTCCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.118967103									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5390	chr2	171570926	171570946	170714416	170714436	77763	hg19					enhancer	enh				GCACAGCTTCTTCCCCTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027790395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5391	chr2	171570927	171570947	170714417	170714437	77764	hg19					enhancer	enh				GACAGCTTCTTCCCCTCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070581194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5392	chr2	171570935	171570955	170714425	170714445	77765	hg19					enhancer	enh				GTTCCCCTCGGGTGGGCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.545228541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5393	chr2	171570936	171570956	170714426	170714446	77766	hg19					enhancer	enh				GTCCCCTCGGGTGGGCATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.285944205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5394	chr2	171570940	171570960	170714430	170714450	77767	hg19					enhancer	enh				GACCCGTCATGCCCACCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002482356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5395	chr2	171570941	171570961	170714431	170714451	77768	hg19					enhancer	enh				GACCCGTCATGCCCACCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.179331644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5396	chr2	171570942	171570962	170714432	170714452	77769	hg19					enhancer	enh				GCGACCCGTCATGCCCACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.246640726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5397	chr2	171570945	171570965	170714435	170714455	77770	hg19					enhancer	enh				GTGGGCATGACGGGTCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.809539225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5398	chr2	171570946	171570966	170714436	170714456	77771	hg19					enhancer	enh				GTGGGCATGACGGGTCGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.263393071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5399	chr2	171570965	171570985	170714455	170714475	77772	hg19					enhancer	enh				GTGAGCTCGGCAGGACACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005411484									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5400	chr2	171570971	171570991	170714461	170714481	77773	hg19					enhancer	enh				GTCCTGCCGAGCTCAGCTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.118948238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5401	chr2	171570972	171570992	170714462	170714482	77774	hg19					enhancer	enh				GCCTGCCGAGCTCAGCTTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274700612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96896	chr2	171570975	171570995	170714465	170714485	77775	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCTCAAAGCTGAGCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.185078083	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171570979	171570999	170714469	170714489	77776	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCATACCCTCAAAGCTGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.423297095	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171570981	171571001	170714471	170714491	77777	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCTCAGCTTTGAGGGTATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.67500017	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171570986	171571006	170714476	170714496	77778	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCTTTGAGGGTATGCGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.811193663	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171570987	171571007	170714477	170714497	77779	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTTTGAGGGTATGCGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.140595131	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571021	171571041	170714511	170714531	77780	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GGTCCACTCTGCAAAAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137418426	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571028	171571048	170714518	170714538	77781	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTCTGCAAAAGTTGTGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.733776853	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571040	171571060	170714530	170714550	77782	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGGCCTGAGGAAAACTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.315469308	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571051	171571071	170714541	170714561	77783	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GAAAACTTCCAGGTCGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274818238	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571061	171571081	170714551	170714571	77784	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGACGTTCCTGCTGGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.799912176	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571062	171571082	170714552	170714572	77785	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTCGCCAGCAGGAACGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342716368	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571069	171571089	170714559	170714579	77786	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCTCTCCTGTGACGTTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.376101742	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571072	171571092	170714562	170714582	77787	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GGAACGTCACAGGAGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.662652317	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571087	171571107	170714577	170714597	77788	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GAGCCCCGGTCGCTCGTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081597541	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571088	171571108	170714578	170714598	77789	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCCGGTCGCTCGTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.164021652	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571091	171571111	170714581	170714601	77790	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCGGTCGCTCGTCAGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149628462	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571092	171571112	170714582	170714602	77791	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCGCCTGACGAGCGACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.447043054	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571093	171571113	170714583	170714603	77792	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGCCCGCCTGACGAGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.483649082	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571094	171571114	170714584	170714604	77793	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCGCCCGCCTGACGAGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.627369832	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571097	171571117	170714587	170714607	77794	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCTCGTCAGGCGGGCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.275123706	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571117	171571137	170714607	170714627	77795	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGGGTGGCGCGCACGCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.311291056	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571118	171571138	170714608	170714628	77796	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTTGGGTGGCGCGCACGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.184643467	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571126	171571146	170714616	170714636	77797	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGCGCCACCCAACGCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.366629007	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571127	171571147	170714617	170714637	77798	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGCCACCCAACGCCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169407225	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571130	171571150	170714620	170714640	77799	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCACCCAACGCCGCGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336696188	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571133	171571153	170714623	170714643	77800	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCGCCCAGCGCGGCGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.133600194	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571136	171571156	170714626	170714646	77801	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGGCCGCCCAGCGCGGCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.523188118	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571137	171571157	170714627	170714647	77802	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGGCCGCCCAGCGCGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223473286	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571138	171571158	170714628	170714648	77803	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGCCGCGCTGGGCGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119739312	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571143	171571163	170714633	170714653	77804	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GGCCGGGCGGCCGCCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.247154068	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571169	171571189	170714659	170714679	77805	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GAGGGCAGGGCTGTGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.565585599	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571171	171571191	170714661	170714681	77806	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCGAGGGCAGGGCTGTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.67777893	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571179	171571199	170714669	170714689	77807	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCTGCCCTCGGCCCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.172330277	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571182	171571202	170714672	170714692	77808	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGCCCTCGGCCCCACCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250259041	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571183	171571203	170714673	170714693	77809	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCTCGGCCCCACCGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092395551	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571186	171571206	170714676	170714696	77810	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCTCGGCCCCACCGCGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.131306369	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571187	171571207	170714677	170714697	77811	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTCGGCCCCACCGCGGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238381346	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571187	171571207	170714677	170714697	77812	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCCCGCCGCGGTGGGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.664707764	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571188	171571208	170714678	170714698	77813	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGGCCCCACCGCGGCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.054728802	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571189	171571209	170714679	170714699	77814	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GGCCCCACCGCGGCGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.650447297	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571194	171571214	170714684	170714704	77815	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTCCCCCGCCCGCCGCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.279633414	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571195	171571215	170714685	170714705	77816	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGTCCCCCGCCCGCCGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.028604195	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571196	171571216	170714686	170714706	77817	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GTGTCCCCCGCCCGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.740524668	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96896	chr2	171571199	171571219	170714689	170714709	77818	hg19	N/A	N/A	fant9229	N/A	enhancer	enh				GCGCGTGTCCCCCGCCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.338184669	SP5	chr2	170715336	170718078	631				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8822
enhrx-96897	chr2	171571227	171571247	170714717	170714737	77819	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCGTGGGACCGACAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.441596044	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571231	171571251	170714721	170714741	77820	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGTCGGTCCCACGCCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.185746098	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571232	171571252	170714722	170714742	77821	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGTCGGTCCCACGCCCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.463865811	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571233	171571253	170714723	170714743	77822	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCGGTCCCACGCCCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.452144279	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571242	171571262	170714732	170714752	77823	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGAGATCCCCGGTGGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.43828996	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571243	171571263	170714733	170714753	77824	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGAGATCCCCGGTGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.3096256	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571244	171571264	170714734	170714754	77825	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCCCACCGGGGATCTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.340394802	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571245	171571265	170714735	170714755	77826	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCCCACCGGGGATCTCGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.092458054	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571248	171571268	170714738	170714758	77827	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCCAAGCGAGATCCCCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1087442	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571249	171571269	170714739	170714759	77828	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACCCAAGCGAGATCCCCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265649176	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571250	171571270	170714740	170714760	77829	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACCCAAGCGAGATCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.404914546	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571253	171571273	170714743	170714763	77830	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGACCCAAGCGAGATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.681090721	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571261	171571281	170714751	170714771	77831	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTTGGGTCCGCTGTGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.14542381	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571262	171571282	170714752	170714772	77832	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTTGGGTCCGCTGTGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283241389	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571266	171571286	170714756	170714776	77833	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGTCCGCTGTGTGCGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.258353652	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571272	171571292	170714762	170714782	77834	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCACCCGCCCGCGCACACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225858443	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571308	171571328	170714798	170714818	77835	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGGGTGTGCAAGTAAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.505449585	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571309	171571329	170714799	170714819	77836	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGGTGTGCAAGTAAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09264745	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571310	171571330	170714800	170714820	77837	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGGTGTGCAAGTAAATACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.333596509	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571342	171571362	170714832	170714852	77838	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCTTTGCCGTCTCAAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068128241	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571349	171571369	170714839	170714859	77839	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGTCTCAAAGTCCGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081966872	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571352	171571372	170714842	170714862	77840	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCAGGCGCCGGACTTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.617947916	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571359	171571379	170714849	170714869	77841	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCCGGCGCCTGGAAGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.367605038	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571364	171571384	170714854	170714874	77842	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGCCTTCGGCTTCCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334311409	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571370	171571390	170714860	170714880	77843	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAAATCTGCCTTCGGCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.427556528	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571378	171571398	170714868	170714888	77844	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCTCTGGAAAAATCTGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.546127153	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571400	171571420	170714890	170714910	77845	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACAAAGACACTTTGTCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.463863484	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571401	171571421	170714891	170714911	77846	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAAAGACACTTTGTCACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.625023661	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571412	171571432	170714902	170714922	77847	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGTCACTTTGGGCGCTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.224447754	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571500	171571520	170714990	170715010	77848	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGTCTCGAGCAACCCAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.289125301	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571501	171571521	170714991	170715011	77849	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCTCGAGCAACCCAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005919085	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571509	171571529	170714999	170715019	77850	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAACCCAAGCGCGGGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105524176	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571512	171571532	170715002	170715022	77851	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCCAAGCGCGGGTCTCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054842963	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571515	171571535	170715005	170715025	77852	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGCCTGGAGACCCGCGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279212943	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571516	171571536	170715006	170715026	77853	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGCCTGGAGACCCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051912523	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571517	171571537	170715007	170715027	77854	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGCGGGTCTCCAGGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.235513035	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571530	171571550	170715020	170715040	77855	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCAAAGGGGGCCTTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.058931196	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571532	171571552	170715022	170715042	77856	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGCAAGGCCCCCTTTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.453283578	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571587	171571607	170715077	170715097	77857	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTAATGAAGTAATCACTATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.561821973	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571588	171571608	170715078	170715098	77858	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTTAATGAAGTAATCACTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.573520601	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571615	171571635	170715105	170715125	77859	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGAAGGGAGGAGATAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.10488007	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571631	171571651	170715121	170715141	77860	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATTATTAGGGGGGATGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-4.011045465	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571632	171571652	170715122	170715142	77861	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATTATTAGGGGGGATGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.155890917	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571636	171571656	170715126	170715146	77862	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAACTGATTATTAGGGGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.503523675	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571637	171571657	170715127	170715147	77863	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAACTGATTATTAGGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.624542519	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571641	171571661	170715131	170715151	77864	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAAAGAACTGATTATTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151807651	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571642	171571662	170715132	170715152	77865	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTAAAAGAACTGATTATTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.850537303	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571643	171571663	170715133	170715153	77866	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATAAAAGAACTGATTATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.439100526	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571644	171571664	170715134	170715154	77867	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATAAAAGAACTGATTATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.403794886	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571645	171571665	170715135	170715155	77868	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGATAAAAGAACTGATTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096589342	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571664	171571684	170715154	170715174	77869	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGACCAACAAACACACCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.002021075	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571674	171571694	170715164	170715184	77870	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAACACACCATAGGAGCTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.873412897	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571683	171571703	170715173	170715193	77871	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTAGGAGCTTTGTGGATTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.389914566	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571683	171571703	170715173	170715193	77872	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTTGAATCCACAAAGCTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59703778	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571732	171571752	170715222	170715242	77873	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACCCAATCATCAAAGAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.318445197	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571768	171571789	170715258	170715279	77874	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCATAAATCTTCCCTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	direct	Highly Significant	NA				0.375471917	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571769	171571789	170715259	170715279	77875	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCATAAATCTTCCCTCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23328542	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571772	171571792	170715262	170715282	77876	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCAGTCAGAGGGAAGATTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.163415598	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571773	171571793	170715263	170715283	77877	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAATCTTCCCTCTGACTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.004967475	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571776	171571796	170715266	170715286	77878	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCTTCCCTCTGACTGGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.249127836	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571783	171571803	170715273	170715293	77879	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGGGCCGCCAGCCAGTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.241299563	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571783	171571805	170715273	170715295	77880	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGGCCGCCAGCCAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	indirect	Non Significant	NA				-0.386327341	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571784	171571804	170715274	170715294	77881	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGGCCGCCAGCCAGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119691708	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571803	171571823	170715293	170715313	77882	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAATTTGATAAGGACTTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.4861112	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571804	171571824	170715294	170715314	77883	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAAAGTCCTTATCAAATTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1071311	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571813	171571833	170715303	170715323	77884	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCACCTCCAAGAATTTGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.495315799	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571813	171571835	170715303	170715325	77885	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATCACCTCCAAGAATTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	direct	Highly Significant	NA				0.207405131	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571836	171571856	170715326	170715346	77886	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGAAGCGCTCAGACCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201648392	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571837	171571857	170715327	170715347	77887	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAGCGCTCAGACCGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025084735	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571837	171571857	170715327	170715347	77888	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGCGCGGTCTGAGCGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.035597744	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571838	171571858	170715328	170715348	77889	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAGCGCTCAGACCGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.181539623	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571852	171571872	170715342	170715362	77890	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGCTCGCTCGCCCCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.056032647	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571895	171571917	170715385	170715407	77891	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGAGGGCCCCGGCGCTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	indirect	Non Significant	NA				-0.028980835	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571896	171571917	170715386	170715407	77892	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGGCCCCGGCGCTCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	indirect	Non Significant	NA				0.003738474	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571897	171571917	170715387	170715407	77893	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGGCCCCGGCGCTCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.588682465	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571904	171571924	170715394	170715414	77894	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCGCCTGCTCTGAGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.17204283	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571904	171571924	170715394	170715414	77895	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGCGCTCAGAGCAGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.237588768	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571905	171571925	170715395	170715415	77896	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCGCTCAGAGCAGGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.194798665	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571905	171571925	170715395	170715415	77897	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGGCGCCTGCTCTGAGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.110350415	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571906	171571926	170715396	170715416	77898	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGCGCCTGCTCTGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.008825531	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571908	171571928	170715398	170715418	77899	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCAGAGCAGGCGCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.03964577	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571940	171571960	170715430	170715450	77900	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGCCCTTCGTCCTCGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.268230632	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571941	171571961	170715431	170715451	77901	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCCCTTCGTCCTCGCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076603455	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571946	171571966	170715436	170715456	77902	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCACCCGAAGGCGAGGACGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.201334289	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571947	171571967	170715437	170715457	77903	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACACCCGAAGGCGAGGACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.13952599	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571954	171571974	170715444	170715464	77904	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCATGGACACCCGAAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.421720702	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571955	171571975	170715445	170715465	77905	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTTCGGGTGTCCATGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.680731285	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571958	171571978	170715448	170715468	77906	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTTCGGGTGTCCATGCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.066528901	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571959	171571979	170715449	170715469	77907	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGAGGCATGGACACCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257080238	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571961	171571981	170715451	170715471	77908	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGGTGTCCATGCCTCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295861015	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571970	171571990	170715460	170715480	77909	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGGACGCCGCCGCCGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.577658075	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571975	171571995	170715465	170715485	77910	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGAGCGGGACGCCGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159814731	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571981	171572001	170715471	170715491	77911	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGCGTCCCGCTCCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264442128	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571982	171572002	170715472	170715492	77912	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCGTCCCGCTCCGCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.612400171	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571983	171572003	170715473	170715493	77913	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGTCCCGCTCCGCAGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09719788	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571990	171572010	170715480	170715500	77914	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGGCCCCTGGCTGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.52577368	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171571991	171572011	170715481	170715501	77915	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGGCCCCTGGCTGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274708305	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572002	171572022	170715492	170715512	77916	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCTACGGCTTGCAGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.957934483	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572003	171572023	170715493	170715513	77917	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGGCCTGCAAGCCGTAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082447457	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572009	171572029	170715499	170715519	77918	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAAGCCGTAGCCATGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.131847587	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572009	171572029	170715499	170715519	77919	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGCCATGGCTACGGCTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.37990755	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572012	171572032	170715502	170715522	77920	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGCCGTAGCCATGGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.062630144	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572017	171572037	170715507	170715527	77921	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCCACCGCGGCCATGGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.303856168	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572023	171572043	170715513	170715533	77922	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGGCCGCGGTGGCCGTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.282230186	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572023	171572043	170715513	170715533	77923	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGACGGCCACCGCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.65739174	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572029	171572049	170715519	170715539	77924	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTTCCGGAGGACGGCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.18834818	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572037	171572059	170715527	170715549	77925	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCCTCCGGAACGACTCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	direct	Highly Significant	NA				0.627873504	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572038	171572058	170715528	170715548	77926	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGCGAGTCGTTCCGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.067057356	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572039	171572059	170715529	170715549	77927	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTCCGGAACGACTCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.284988856	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572042	171572062	170715532	170715552	77928	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTGCAGCGAGTCGTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.292091253	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572042	171572063	170715532	170715553	77929	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTGCAGCGAGTCGTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LINC01124	indirect	Non Significant	NA				-0.10995201	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572045	171572065	170715535	170715555	77930	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGCCTGCAGCGAGTCGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.848387788	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572051	171572071	170715541	170715561	77931	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCGCTGCAGGCCTTTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452331147	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572056	171572076	170715546	170715566	77932	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGCAGGCCTTTCTCCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.749828548	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572057	171572077	170715547	170715567	77933	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGGCCTTTCTCCAGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.556130953	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572065	171572085	170715555	170715575	77934	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCGGCCCTGACCTGGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214648078	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572067	171572087	170715557	170715577	77935	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCCAGGTCAGGGCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.11702927	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572070	171572090	170715560	170715580	77936	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGGTCAGGGCCGAGCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.098752086	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572071	171572091	170715561	170715581	77937	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGGTCAGGGCCGAGCCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.065480419	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572072	171572092	170715562	170715582	77938	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCCGGGCTCGGCCCTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.781370812	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572072	171572092	170715562	170715582	77939	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGTCAGGGCCGAGCCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.426690934	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572073	171572093	170715563	170715583	77940	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCAGGGCCGAGCCCGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.201465682	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572083	171572103	170715573	170715593	77941	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCTCCCGCCCCCTCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228244465	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572088	171572108	170715578	170715598	77942	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACCTTTCTCCCGCCCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.063469306	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572089	171572109	170715579	170715599	77943	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCACCTTTCTCCCGCCCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.143192216	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572103	171572123	170715593	170715613	77944	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAGGTGGAAAGGGCCGTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.909361074	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572114	171572134	170715604	170715624	77945	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCCGTGTCCGGATCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275462556	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572119	171572139	170715609	170715629	77946	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTACCAGGAGAGATCCGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.730351762	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572125	171572145	170715615	170715635	77947	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACGGAGTACCAGGAGAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007481761	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572135	171572155	170715625	170715645	77948	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTTCAAGGTGCACGGAGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.482977354	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572141	171572161	170715631	170715651	77949	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGTGCACCTTGAACCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.59489628	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572142	171572162	170715632	170715652	77950	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGTGCACCTTGAACCTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428626359	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572144	171572164	170715634	170715654	77951	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTTTGAGGTTCAAGGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.008151433	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572151	171572171	170715641	170715661	77952	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGGGTTCCCTTTGAGGTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.750452283	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572156	171572176	170715646	170715666	77953	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCAAAGGGAACCCCGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.015026757	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572157	171572177	170715647	170715667	77954	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCAAAGGGAACCCCGCCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.509806874	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572166	171572186	170715656	170715676	77955	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACCCCGCCGATGGGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.075172857	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572170	171572190	170715660	170715680	77956	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCCAGCTGCACCCATCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186519527	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572171	171572191	170715661	170715681	77957	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCCAGCTGCACCCATCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.018131061	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572172	171572192	170715662	170715682	77958	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTCCAGCTGCACCCATCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.071564477	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572173	171572193	170715663	170715683	77959	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGATGGGTGCAGCTGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.065555492	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572175	171572195	170715665	170715685	77960	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGCTCCAGCTGCACCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133774	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572180	171572200	170715670	170715690	77961	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGCAGCTGGAGCCAGGCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375486693	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572181	171572201	170715671	170715691	77962	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCAGCTGGAGCCAGGCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.735952972	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572194	171572214	170715684	170715704	77963	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GGCGTGGGCACCCCTAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.763344922	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572199	171572219	170715689	170715709	77964	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAAGTTGGCGTGGGCACCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.573270871	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572209	171572229	170715699	170715719	77965	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATTAGGTGTGAAGTTGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.844674893	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572210	171572230	170715700	170715720	77966	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATTAGGTGTGAAGTTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.547244965	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572210	171572230	170715700	170715720	77967	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGCCAACTTCACACCTAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.334862286	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572215	171572235	170715705	170715725	77968	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GACTTCACACCTAATCCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.388425792	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572215	171572235	170715705	170715725	77969	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCACCGGATTAGGTGTGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.161569844	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572225	171572245	170715715	170715735	77970	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTAATCCGGTGTGGCCTTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.318330823	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572226	171572246	170715716	170715736	77971	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GAGCAAAGGCCACACCGGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096914323	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572228	171572248	170715718	170715738	77972	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCCGGTGTGGCCTTTGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.356130866	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572229	171572249	170715719	170715739	77973	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCGGTGTGGCCTTTGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.535677374	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572232	171572252	170715722	170715742	77974	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCCTCCAGCAAAGGCCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.352443292	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572237	171572257	170715727	170715747	77975	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCCTTTGCTGGAGGGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.572909522	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572241	171572261	170715731	170715751	77976	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTCCACGCGTCCCTCCAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126257477	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572243	171572263	170715733	170715753	77977	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGAGGGACGCGTGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.533528564	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572244	171572264	170715734	170715754	77978	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCTGGAGGGACGCGTGGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.628856122	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572253	171572273	170715743	170715763	77979	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGCGTGGATCCGGGATTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.020486713	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572256	171572276	170715746	170715766	77980	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GTGGATCCGGGATTGTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.310558966	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572263	171572283	170715753	170715773	77981	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGGATTGTTCGGAGGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165596225	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572265	171572285	170715755	170715775	77982	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GCGGGCACCTCCGAACAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.277535688	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-96897	chr2	171572267	171572287	170715757	170715777	77983	hg19	N/A	N/A	N/A	Enhatls103713	enhancer	enh				GATTGTTCGGAGGTGCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.074517235	SP5	chr2	170715336	170718078	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8823
enhrx-lit5402	chr2	171572278	171572298	170715768	170715788	77984	hg19					enhancer	enh				GTGCCCGGCTGGCCGAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.069582846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5403	chr2	171572283	171572303	170715773	170715793	77985	hg19					enhancer	enh				GCGGCTGGCCGAGAACAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.313121444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5404	chr2	171572284	171572304	170715774	170715794	77986	hg19					enhancer	enh				GGTCCTGTTCTCGGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320936244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5405	chr2	171572285	171572305	170715775	170715795	77987	hg19					enhancer	enh				GCGGTCCTGTTCTCGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.624189456									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5406	chr2	171572293	171572313	170715783	170715803	77988	hg19					enhancer	enh				GTGAGCTCCGGTCCTGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15857369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5407	chr2	171572298	171572318	170715788	170715808	77989	hg19					enhancer	enh				GAGGACCGGAGCTCACCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061506758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5408	chr2	171572299	171572319	170715789	170715809	77990	hg19					enhancer	enh				GGACCGGAGCTCACCCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.41317163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5409	chr2	171572305	171572325	170715795	170715815	77991	hg19					enhancer	enh				GGGCCCAGCAGGGTGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.442011943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5410	chr2	171572315	171572335	170715805	170715825	77992	hg19					enhancer	enh				GATCAGCAGGAGGGCCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.722028553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5411	chr2	171572316	171572336	170715806	170715826	77993	hg19					enhancer	enh				GAATCAGCAGGAGGGCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.624663659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5412	chr2	171572322	171572342	170715812	170715832	77994	hg19					enhancer	enh				GCCCTCCTGCTGATTTCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.117812632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5413	chr2	171572323	171572343	170715813	170715833	77995	hg19					enhancer	enh				GCCTCCTGCTGATTTCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105428687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5414	chr2	171572324	171572344	170715814	170715834	77996	hg19					enhancer	enh				GCTCCTGCTGATTTCAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.291149108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5415	chr2	171572325	171572345	170715815	170715835	77997	hg19					enhancer	enh				GCCAGGCTGAAATCAGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305534705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5416	chr2	171572326	171572346	170715816	170715836	77998	hg19					enhancer	enh				GCCCAGGCTGAAATCAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.001429733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5417	chr2	171572327	171572347	170715817	170715837	77999	hg19					enhancer	enh				GCTGCTGATTTCAGCCTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.026607278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5418	chr2	171572328	171572348	170715818	170715838	78000	hg19					enhancer	enh				GTGCTGATTTCAGCCTGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.390835192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5419	chr2	171572329	171572349	170715819	170715839	78001	hg19					enhancer	enh				GCGCCCCAGGCTGAAATCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151585663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5420	chr2	171572333	171572353	170715823	170715843	78002	hg19					enhancer	enh				GATTTCAGCCTGGGGCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.377949215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5421	chr2	171572334	171572354	170715824	170715844	78003	hg19					enhancer	enh				GTTTCAGCCTGGGGCGGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.877250976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5422	chr2	171572354	171572374	170715844	170715864	78004	hg19					enhancer	enh				GACTGCCTTCGCGCTCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.561383567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5423	chr2	171572376	171572396	170715866	170715886	78005	hg19					enhancer	enh				GGACAAGAGAGCTTAAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1962981									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5424	chr2	171572377	171572397	170715867	170715887	78006	hg19					enhancer	enh				GACAAGAGAGCTTAAAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257001593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5425	chr2	171572380	171572400	170715870	170715890	78007	hg19					enhancer	enh				GAAGAGAGCTTAAAAGATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378365518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5426	chr2	171572381	171572401	170715871	170715891	78008	hg19					enhancer	enh				GAGAGAGCTTAAAAGATGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.218601986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5427	chr2	171572414	171572434	170715904	170715924	78009	hg19					enhancer	enh				GACACCCACAACCCCGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.319053227									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5428	chr2	171572418	171572438	170715908	170715928	78010	hg19					enhancer	enh				GGAAACACCCACAACCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.010990112									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5429	chr2	171572434	171572454	170715924	170715944	78011	hg19					enhancer	enh				GTTCCCGACTCTTACTGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.144981121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5430	chr2	171572439	171572459	170715929	170715949	78012	hg19					enhancer	enh				GCTCCGTGGTCAGTAAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171641793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5431	chr2	171572440	171572460	170715930	170715950	78013	hg19					enhancer	enh				GCTCCGTGGTCAGTAAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.64059095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5432	chr2	171572440	171572460	170715930	170715950	78014	hg19					enhancer	enh				GACTCTTACTGACCACGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.409215207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5433	chr2	171572441	171572461	170715931	170715951	78015	hg19					enhancer	enh				GCTCTTACTGACCACGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264720821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5434	chr2	171572444	171572464	170715934	170715954	78016	hg19					enhancer	enh				GTTACTGACCACGGAGCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.649738909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5435	chr2	171572445	171572465	170715935	170715955	78017	hg19					enhancer	enh				GTACTGACCACGGAGCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.534570846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5436	chr2	171572446	171572466	170715936	170715956	78018	hg19					enhancer	enh				GACTGACCACGGAGCCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.974385733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5437	chr2	171572454	171572474	170715944	170715964	78019	hg19					enhancer	enh				GACGGGCCCCTCCCGGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165423888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5438	chr2	171572462	171572482	170715952	170715972	78020	hg19					enhancer	enh				GGCATCCGACGGGCCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.722472798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5439	chr2	171572488	171572508	170715978	170715998	78021	hg19					enhancer	enh				GAAGCAGGCGCGAAGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.595386423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5440	chr2	171572493	171572513	170715983	170716003	78022	hg19					enhancer	enh				GCTTCGCGCCTGCTTCCTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068801631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5441	chr2	171572497	171572517	170715987	170716007	78023	hg19					enhancer	enh				GCGCCTGCTTCCTCTAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.002599293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5442	chr2	171572501	171572521	170715991	170716011	78024	hg19					enhancer	enh				GCTGCTTCCTCTAAGGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.447470021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5443	chr2	171572503	171572523	170715993	170716013	78025	hg19					enhancer	enh				GCATCCAGCCTTAGAGGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227964128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5444	chr2	171572510	171572530	170716000	170716020	78026	hg19					enhancer	enh				GAGACGCCATCCAGCCTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.185894088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5445	chr2	171572539	171572559	170716029	170716049	78027	hg19					enhancer	enh				GCGCTTCTTGCTAAACTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265388295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5446	chr2	171572542	171572562	170716032	170716052	78028	hg19					enhancer	enh				GAGTTTAGCAAGAAGCGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.05370502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5447	chr2	171572543	171572563	170716033	170716053	78029	hg19					enhancer	enh				GTTTAGCAAGAAGCGCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.648383954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5448	chr2	171572556	171572576	170716046	170716066	78030	hg19					enhancer	enh				GCGCTCGCGGGCCCCACGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.270977081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5449	chr2	171572565	171572585	170716055	170716075	78031	hg19					enhancer	enh				GCCCCACGTTCAGGTAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.19437563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5450	chr2	171572569	171572589	170716059	170716079	78032	hg19					enhancer	enh				GCCTGCGCTACCTGAACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183127193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5451	chr2	171572570	171572590	170716060	170716080	78033	hg19					enhancer	enh				GTGCCTGCGCTACCTGAACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.802333394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5452	chr2	171572571	171572591	170716061	170716081	78034	hg19					enhancer	enh				GTGCCTGCGCTACCTGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.454571126									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5453	chr2	171572584	171572604	170716074	170716094	78035	hg19					enhancer	enh				GCAGGCACCAAAAGTTTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.163738398									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5454	chr2	171572588	171572608	170716078	170716098	78036	hg19					enhancer	enh				GCACCAAAAGTTTCCCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138332325									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5455	chr2	171572591	171572611	170716081	170716101	78037	hg19					enhancer	enh				GCAAAAGTTTCCCTCGGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.554509996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5456	chr2	171572592	171572612	170716082	170716102	78038	hg19					enhancer	enh				GAAAAGTTTCCCTCGGCCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.88388858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5457	chr2	171572593	171572613	170716083	170716103	78039	hg19					enhancer	enh				GCACCGGCCGAGGGAAACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.330572026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5458	chr2	171572603	171572623	170716093	170716113	78040	hg19					enhancer	enh				GCGCACGCACCCACCGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.76174642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5459	chr2	171572604	171572624	170716094	170716114	78041	hg19					enhancer	enh				GACGCACGCACCCACCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.071105088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5460	chr2	171572610	171572630	170716100	170716120	78042	hg19					enhancer	enh				GCACCCCACGCACGCACCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.355098281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5461	chr2	171572653	171572673	170716143	170716163	78043	hg19					enhancer	enh				GCCGCCGCCCCTCCTCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200862987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5462	chr2	171572661	171572681	170716151	170716171	78044	hg19					enhancer	enh				GAGGGGCGGCGGTATAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202303827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5463	chr2	171572662	171572682	170716152	170716172	78045	hg19					enhancer	enh				GAGGGGCGGCGGTATAATAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.102802058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5464	chr2	171572667	171572687	170716157	170716177	78046	hg19					enhancer	enh				GCGGCGGTATAATAGCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.295573257									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5465	chr2	171572668	171572688	170716158	170716178	78047	hg19					enhancer	enh				GGCGGTATAATAGCGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.663726053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5466	chr2	171572669	171572689	170716159	170716179	78048	hg19					enhancer	enh				GCGGTATAATAGCGGGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.383953524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5467	chr2	171572670	171572690	170716160	170716180	78049	hg19					enhancer	enh				GCGGTATAATAGCGGGCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.663734619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5468	chr2	171572699	171572719	170716189	170716209	78050	hg19					enhancer	enh				GCTGGCCCGGAGTCCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227912643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5469	chr2	171572707	171572727	170716197	170716217	78051	hg19					enhancer	enh				GTAGCTCCAAGCGCGGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057549016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5470	chr2	171572708	171572728	170716198	170716218	78052	hg19					enhancer	enh				GTTAGCTCCAAGCGCGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.124547584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5471	chr2	171572715	171572735	170716205	170716225	78053	hg19					enhancer	enh				GCAAAAGGTTAGCTCCAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043482317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5472	chr2	171572731	171572751	170716221	170716241	78054	hg19					enhancer	enh				GAGGGCGGAGAAGAGACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.162995554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5473	chr2	171572746	171572766	170716236	170716256	78055	hg19					enhancer	enh				GCCCTCCCTCGCCGCCTATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.254143652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5474	chr2	171572749	171572769	170716239	170716259	78056	hg19					enhancer	enh				GCCTGCATAGGCGGCGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-4.771676621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5475	chr2	171572750	171572770	170716240	170716260	78057	hg19					enhancer	enh				GTCCTGCATAGGCGGCGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.380712649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5476	chr2	171572753	171572773	170716243	170716263	78058	hg19					enhancer	enh				GCGGTCCTGCATAGGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.038189777									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5477	chr2	171572754	171572774	170716244	170716264	78059	hg19					enhancer	enh				GCGGTCCTGCATAGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121843286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5478	chr2	171572759	171572779	170716249	170716269	78060	hg19					enhancer	enh				GGGGTGCGGTCCTGCATAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.112832021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5479	chr2	171572762	171572782	170716252	170716272	78061	hg19					enhancer	enh				GCTGGGGGTGCGGTCCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239466209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5480	chr2	171572770	171572790	170716260	170716280	78062	hg19					enhancer	enh				GCCGCACCCCCAGCGCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.422905729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5481	chr2	171572776	171572796	170716266	170716286	78063	hg19					enhancer	enh				GCCCCAGCGCCTCCCCGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158909955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5482	chr2	171572777	171572797	170716267	170716287	78064	hg19					enhancer	enh				GCCCAGCGCCTCCCCGGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.268814036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5483	chr2	171572780	171572800	170716270	170716290	78065	hg19					enhancer	enh				GCCCAGGTCCGGGGAGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217585772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5484	chr2	171572781	171572801	170716271	170716291	78066	hg19					enhancer	enh				GCCCAGGTCCGGGGAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.244757449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5485	chr2	171572787	171572807	170716277	170716297	78067	hg19					enhancer	enh				GTGCTTGCCCAGGTCCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.193168214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5486	chr2	171572790	171572810	170716280	170716300	78068	hg19					enhancer	enh				GCGAGTGCTTGCCCAGGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.17406007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5487	chr2	171572791	171572811	170716281	170716301	78069	hg19					enhancer	enh				GCGAGTGCTTGCCCAGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.997452002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5488	chr2	171572792	171572812	170716282	170716302	78070	hg19					enhancer	enh				GGCGAGTGCTTGCCCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134276964									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5489	chr2	171572794	171572814	170716284	170716304	78071	hg19					enhancer	enh				GCCTGGGCAAGCACTCGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.042545739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5490	chr2	171572797	171572817	170716287	170716307	78072	hg19					enhancer	enh				GCCAGGGGCGAGTGCTTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.546780854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5491	chr2	171572803	171572823	170716293	170716313	78073	hg19					enhancer	enh				GCACTCGCCCCTGGCATTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.160848419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5492	chr2	171572813	171572833	170716303	170716323	78074	hg19					enhancer	enh				GTGGCGGCCAGCAATGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045047537									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5493	chr2	171572814	171572834	170716304	170716324	78075	hg19					enhancer	enh				GGTGGCGGCCAGCAATGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432444397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5494	chr2	171572815	171572835	170716305	170716325	78076	hg19					enhancer	enh				GAGGTGGCGGCCAGCAATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.007990639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5495	chr2	171572825	171572845	170716315	170716335	78077	hg19					enhancer	enh				GCCGCCACCTGTAGCCGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.549430845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5496	chr2	171572829	171572849	170716319	170716339	78078	hg19					enhancer	enh				GCCGATGCGGCTACAGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.399650121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5497	chr2	171572832	171572852	170716322	170716342	78079	hg19					enhancer	enh				GCTGGCCGATGCGGCTACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.349357914									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5498	chr2	171572833	171572853	170716323	170716343	78080	hg19					enhancer	enh				GCTGTAGCCGCATCGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048814579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5499	chr2	171572834	171572854	170716324	170716344	78081	hg19					enhancer	enh				GTGTAGCCGCATCGGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.320553758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5500	chr2	171572835	171572855	170716325	170716345	78082	hg19					enhancer	enh				GCGGCTGGCCGATGCGGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301261466									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5501	chr2	171572839	171572859	170716329	170716349	78083	hg19					enhancer	enh				GCCGCATCGGCCAGCCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119037789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5502	chr2	171572842	171572862	170716332	170716352	78084	hg19					enhancer	enh				GCCGCGCCCGGCTGGCCGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.004075059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5503	chr2	171572851	171572871	170716341	170716361	78085	hg19					enhancer	enh				GCCGGGCGCGGCGGCGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141543501									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5504	chr2	171572855	171572875	170716345	170716365	78086	hg19					enhancer	enh				GTCCGGGGGCGCCGCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.260040522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5505	chr2	171572863	171572883	170716353	170716373	78087	hg19					enhancer	enh				GGCGCCCCCGGACTTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.149911576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5506	chr2	171572870	171572890	170716360	170716380	78088	hg19					enhancer	enh				GGCACCTGCAGGAAGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.028998411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5507	chr2	171572871	171572891	170716361	170716381	78089	hg19					enhancer	enh				GGGCACCTGCAGGAAGTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19364464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5508	chr2	171572872	171572892	170716362	170716382	78090	hg19					enhancer	enh				GAGGGCACCTGCAGGAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.511957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5509	chr2	171572873	171572893	170716363	170716383	78091	hg19					enhancer	enh				GTAGGGCACCTGCAGGAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.958153847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5510	chr2	171572881	171572901	170716371	170716391	78092	hg19					enhancer	enh				GCGGGGTCGTAGGGCACCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.944036926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5511	chr2	171572884	171572904	170716374	170716394	78093	hg19					enhancer	enh				GGTGCCCTACGACCCCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186529746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5512	chr2	171572885	171572905	170716375	170716395	78094	hg19					enhancer	enh				GTGCCCTACGACCCCGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.487635451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5513	chr2	171572891	171572911	170716381	170716401	78095	hg19					enhancer	enh				GAGCCCAGCGCGGGGTCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.089336881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5514	chr2	171572892	171572912	170716382	170716402	78096	hg19					enhancer	enh				GTGAGCCCAGCGCGGGGTCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175266505									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5515	chr2	171572900	171572920	170716390	170716410	78097	hg19					enhancer	enh				GCTGGAGGGTGAGCCCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023258225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5516	chr2	171572913	171572933	170716403	170716423	78098	hg19					enhancer	enh				GCCTCCAGGCTCTTCCACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.355029556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5517	chr2	171572915	171572935	170716405	170716425	78099	hg19					enhancer	enh				GCACGGGTGGAAGAGCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004271949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5518	chr2	171572916	171572936	170716406	170716426	78100	hg19					enhancer	enh				GCCACGGGTGGAAGAGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012909862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5519	chr2	171572919	171572939	170716409	170716429	78101	hg19					enhancer	enh				GGTCCACGGGTGGAAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068360446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5520	chr2	171572929	171572949	170716419	170716439	78102	hg19					enhancer	enh				GCATGTCGGCGGTCCACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.002942906									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5521	chr2	171572929	171572949	170716419	170716439	78103	hg19					enhancer	enh				GCCCGTGGACCGCCGACATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284818532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5522	chr2	171572932	171572952	170716422	170716442	78104	hg19					enhancer	enh				GCCGGCATGTCGGCGGTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.575715443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5523	chr2	171572933	171572953	170716423	170716443	78105	hg19					enhancer	enh				GCCGGCATGTCGGCGGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.511899606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5524	chr2	171572940	171572960	170716430	170716450	78106	hg19					enhancer	enh				GCGAGTGCGCCGGCATGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.298708273									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5525	chr2	171572942	171572962	170716432	170716452	78107	hg19					enhancer	enh				GACATGCCGGCGCACTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.281984037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5526	chr2	171572943	171572963	170716433	170716453	78108	hg19					enhancer	enh				GTGGCGAGTGCGCCGGCATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280328947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5527	chr2	171572951	171572971	170716441	170716461	78109	hg19					enhancer	enh				GAGTGCGCCTGGCGAGTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.179288306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5528	chr2	171572971	171572991	170716461	170716481	78110	hg19					enhancer	enh				GCCGCCCCCGCATCCCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.027135394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5529	chr2	171572973	171572993	170716463	170716483	78111	hg19					enhancer	enh				GCGCCCCCGCATCCCAGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279172443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5530	chr2	171572978	171572998	170716468	170716488	78112	hg19					enhancer	enh				GAGCCCCAAGCTGGGATGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.222121882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5531	chr2	171572979	171572999	170716469	170716489	78113	hg19					enhancer	enh				GCAGCCCCAAGCTGGGATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048811591									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5532	chr2	171572980	171573000	170716470	170716490	78114	hg19					enhancer	enh				GTCAGCCCCAAGCTGGGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.593998362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5533	chr2	171572981	171573001	170716471	170716491	78115	hg19					enhancer	enh				GTCAGCCCCAAGCTGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.332421172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5534	chr2	171572987	171573007	170716477	170716497	78116	hg19					enhancer	enh				GTGCGGCGTCAGCCCCAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036789934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5535	chr2	171572988	171573008	170716478	170716498	78117	hg19					enhancer	enh				GCTGCGGCGTCAGCCCCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.623973773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5536	chr2	171573005	171573025	170716495	170716515	78118	hg19					enhancer	enh				GGCTGCAGGTGCGTCTTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121346453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5537	chr2	171573011	171573031	170716501	170716521	78119	hg19					enhancer	enh				GACGCACCTGCAGCCGTCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136903683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5538	chr2	171573012	171573032	170716502	170716522	78120	hg19					enhancer	enh				GCGCACCTGCAGCCGTCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.544368064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5539	chr2	171573013	171573033	170716503	170716523	78121	hg19					enhancer	enh				GCACCTGCAGCCGTCCTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.275004646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5540	chr2	171573019	171573039	170716509	170716529	78122	hg19					enhancer	enh				GCAGCCCCGAAGGACGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.110685645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5541	chr2	171573026	171573046	170716516	170716536	78123	hg19					enhancer	enh				GTCGTGCGCAGCCCCGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.52307761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5542	chr2	171573030	171573050	170716520	170716540	78124	hg19					enhancer	enh				GAAGCTCGTGCGCAGCCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28007287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5543	chr2	171573073	171573093	170716563	170716583	78125	hg19					enhancer	enh				GAGAACTCGTAGGGGTACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.330349096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5544	chr2	171573074	171573094	170716564	170716584	78126	hg19					enhancer	enh				GAGAACTCGTAGGGGTACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.25217873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5545	chr2	171573075	171573095	170716565	170716585	78127	hg19					enhancer	enh				GCGAGAACTCGTAGGGGTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068056954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5546	chr2	171573076	171573096	170716566	170716586	78128	hg19					enhancer	enh				GTACCCCTACGAGTTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145885996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5547	chr2	171573082	171573102	170716572	170716592	78129	hg19					enhancer	enh				GTGACCGGCGAGAACTCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.704515867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5548	chr2	171573083	171573103	170716573	170716593	78130	hg19					enhancer	enh				GTTGACCGGCGAGAACTCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.102827894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5549	chr2	171573084	171573104	170716574	170716594	78131	hg19					enhancer	enh				GCTTGACCGGCGAGAACTCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.545355011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5550	chr2	171573098	171573118	170716588	170716608	78132	hg19					enhancer	enh				GCTCGAGGGCAGCATCTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.851468947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5551	chr2	171573100	171573120	170716590	170716610	78133	hg19					enhancer	enh				GCAAGATGCTGCCCTCGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045029904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5552	chr2	171573103	171573123	170716593	170716613	78134	hg19					enhancer	enh				GATGCTGCCCTCGAGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171250432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5553	chr2	171573113	171573133	170716603	170716623	78135	hg19					enhancer	enh				GGCAGAGCCGCCATGCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.484483464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5554	chr2	171573114	171573134	170716604	170716624	78136	hg19					enhancer	enh				GGGCAGAGCCGCCATGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207471267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5555	chr2	171573138	171573158	170716628	170716648	78137	hg19					enhancer	enh				GCACGTAGGCGGGCGCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.163843872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5556	chr2	171573145	171573165	170716635	170716655	78138	hg19					enhancer	enh				GCCCGCCTACGTGCCCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.015929851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5557	chr2	171573149	171573169	170716639	170716659	78139	hg19					enhancer	enh				GCCGCGTAGGGCACGTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.555828221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5558	chr2	171573150	171573170	170716640	170716660	78140	hg19					enhancer	enh				GCGCCGCGTAGGGCACGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.905185911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5559	chr2	171573151	171573171	170716641	170716661	78141	hg19					enhancer	enh				GCTACGTGCCCTACGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114843996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5560	chr2	171573153	171573173	170716643	170716663	78142	hg19					enhancer	enh				GCTGCGCCGCGTAGGGCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.184968827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5561	chr2	171573161	171573181	170716651	170716671	78143	hg19					enhancer	enh				GAGCGCGGCCTGCGCCGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041167026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5562	chr2	171573162	171573182	170716652	170716672	78144	hg19					enhancer	enh				GCAGCGCGGCCTGCGCCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.008770172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5563	chr2	171573167	171573187	170716657	170716677	78145	hg19					enhancer	enh				GCGCAGGCCGCGCTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00539915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5564	chr2	171573177	171573197	170716667	170716687	78146	hg19					enhancer	enh				GGAGTAGCCTGGCGGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.542686982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5565	chr2	171573185	171573205	170716675	170716695	78147	hg19					enhancer	enh				GAGCAGGTTGGAGTAGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.736927285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5566	chr2	171573188	171573208	170716678	170716698	78148	hg19					enhancer	enh				GGCAGCAGGTTGGAGTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.289344169									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5567	chr2	171573233	171573253	170716723	170716743	78149	hg19					enhancer	enh				GACAACTGGCGGCAGGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.427412057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5568	chr2	171573236	171573256	170716726	170716746	78150	hg19					enhancer	enh				GGTGACAACTGGCGGCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.0120687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5569	chr2	171573237	171573257	170716727	170716747	78151	hg19					enhancer	enh				GGGTGACAACTGGCGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.642521658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5570	chr2	171573240	171573260	170716730	170716750	78152	hg19					enhancer	enh				GTTGGGTGACAACTGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.389962743									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5571	chr2	171573241	171573261	170716731	170716751	78153	hg19					enhancer	enh				GCCGCCAGTTGTCACCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.205396275									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5572	chr2	171573244	171573264	170716734	170716754	78154	hg19					enhancer	enh				GCCGGGTTGGGTGACAACTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.912040857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5573	chr2	171573247	171573267	170716737	170716757	78155	hg19					enhancer	enh				GGGCCGGGTTGGGTGACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301412144									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5574	chr2	171573261	171573281	170716751	170716771	78156	hg19					enhancer	enh				GCGGCCCCCGACGACCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.04764448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5575	chr2	171573264	171573284	170716754	170716774	78157	hg19					enhancer	enh				GCCCCCGACGACCTCCCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225103709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5576	chr2	171573267	171573287	170716757	170716777	78158	hg19					enhancer	enh				GCCACCACGGGAGGTCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.085647051									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5577	chr2	171573268	171573288	170716758	170716778	78159	hg19					enhancer	enh				GTCCACCACGGGAGGTCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.150254208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5578	chr2	171573269	171573289	170716759	170716779	78160	hg19					enhancer	enh				GCTCCACCACGGGAGGTCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.526994547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5579	chr2	171573270	171573290	170716760	170716780	78161	hg19					enhancer	enh				GCTCCACCACGGGAGGTCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334811551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5580	chr2	171573277	171573297	170716767	170716787	78162	hg19					enhancer	enh				GCCCGTGGTGGAGCATCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.293327377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5581	chr2	171573277	171573297	170716767	170716787	78163	hg19					enhancer	enh				GCGGGATGCTCCACCACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.421385677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5582	chr2	171573280	171573300	170716770	170716790	78164	hg19					enhancer	enh				GTGGTGGAGCATCCCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.819116515									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5583	chr2	171573280	171573300	170716770	170716790	78165	hg19					enhancer	enh				GCCTGCGGGATGCTCCACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.348367676									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5584	chr2	171573281	171573301	170716771	170716791	78166	hg19					enhancer	enh				GTGGTGGAGCATCCCGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.128293587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5585	chr2	171573281	171573301	170716771	170716791	78167	hg19					enhancer	enh				GCCTGCGGGATGCTCCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.309630869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5586	chr2	171573287	171573307	170716777	170716797	78168	hg19					enhancer	enh				GAGCATCCCGCAGGCGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.316160346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5587	chr2	171573288	171573308	170716778	170716798	78169	hg19					enhancer	enh				GCATCCCGCAGGCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.1085469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5588	chr2	171573295	171573315	170716785	170716805	78170	hg19					enhancer	enh				GCCGGCCCGGCGCCCGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077047183									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5589	chr2	171573296	171573316	170716786	170716806	78171	hg19					enhancer	enh				GCCCGGCCCGGCGCCCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000487979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5590	chr2	171573303	171573323	170716793	170716813	78172	hg19					enhancer	enh				GCGCCGGGCCGGGGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.16613141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5591	chr2	171573309	171573329	170716799	170716819	78173	hg19					enhancer	enh				GAACCCCGGAGGCCCCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158796138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5592	chr2	171573310	171573330	170716800	170716820	78174	hg19					enhancer	enh				GCCGGGGGCCTCCGGGGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.093153472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5593	chr2	171573311	171573331	170716801	170716821	78175	hg19					enhancer	enh				GCCGGGGGCCTCCGGGGTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261831813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5594	chr2	171573314	171573334	170716804	170716824	78176	hg19					enhancer	enh				GCCCGGAACCCCGGAGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.436634131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5595	chr2	171573317	171573337	170716807	170716827	78177	hg19					enhancer	enh				GCCTCCGGGGTTCCGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.560235106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5596	chr2	171573321	171573341	170716811	170716831	78178	hg19					enhancer	enh				GCCGCTTCCCGGAACCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099762832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5597	chr2	171573324	171573344	170716814	170716834	78179	hg19					enhancer	enh				GAGGCCGCTTCCCGGAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400661966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5598	chr2	171573326	171573346	170716816	170716836	78180	hg19					enhancer	enh				GTTCCGGGAAGCGGCCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.129851003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5599	chr2	171573332	171573352	170716822	170716842	78181	hg19					enhancer	enh				GCGCCGGAGAGGCCGCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.172025086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5600	chr2	171573338	171573358	170716828	170716848	78182	hg19					enhancer	enh				GGCCTCTCCGGCGCCTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.204479108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5601	chr2	171573339	171573359	170716829	170716849	78183	hg19					enhancer	enh				GCCTCTCCGGCGCCTGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.018089829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5602	chr2	171573340	171573360	170716830	170716850	78184	hg19					enhancer	enh				GCCTCTCCGGCGCCTGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052736635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5603	chr2	171573343	171573363	170716833	170716853	78185	hg19					enhancer	enh				GCCCCGGCACAGGCGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.201898733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5604	chr2	171573348	171573368	170716838	170716858	78186	hg19					enhancer	enh				GGGGGCCCCGGCACAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055542441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5605	chr2	171573373	171573393	170716863	170716883	78187	hg19					enhancer	enh				GCCCCGCTTCCCCGCCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.506949978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5606	chr2	171573385	171573405	170716875	170716895	78188	hg19					enhancer	enh				GCAGCAGCGGCCGCAGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.007230103									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5607	chr2	171573387	171573407	170716877	170716897	78189	hg19					enhancer	enh				GAGCAGCAGCGGCCGCAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.266900912									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5608	chr2	171573410	171573430	170716900	170716920	78190	hg19					enhancer	enh				GCCGCCGCCGCCCTACAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104959048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5609	chr2	171573414	171573434	170716904	170716924	78191	hg19					enhancer	enh				GCCTCTTTGTAGGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.155752568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5610	chr2	171573415	171573435	170716905	170716925	78192	hg19					enhancer	enh				GCGCCGCCCTACAAAGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.335806477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5611	chr2	171573417	171573437	170716907	170716927	78193	hg19					enhancer	enh				GCAGGCCTCTTTGTAGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.32186154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5612	chr2	171573420	171573440	170716910	170716930	78194	hg19					enhancer	enh				GCACCAGGCCTCTTTGTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.10990011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5613	chr2	171573421	171573441	170716911	170716931	78195	hg19					enhancer	enh				GCCTACAAAGAGGCCTGGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.525660726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5614	chr2	171573422	171573442	170716912	170716932	78196	hg19					enhancer	enh				GCTACAAAGAGGCCTGGTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021961839									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5615	chr2	171573423	171573443	170716913	170716933	78197	hg19					enhancer	enh				GCAACACCAGGCCTCTTTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077662045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5616	chr2	171573424	171573444	170716914	170716934	78198	hg19					enhancer	enh				GCCAACACCAGGCCTCTTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124439344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5617	chr2	171573430	171573450	170716920	170716940	78199	hg19					enhancer	enh				GAGGCCTGGTGTTGGGCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033522317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5618	chr2	171573436	171573456	170716926	170716946	78200	hg19					enhancer	enh				GAGTCCGACGGGCCCAACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.529692067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5619	chr2	171573448	171573468	170716938	170716958	78201	hg19					enhancer	enh				GGTACTGCGCAAAGTCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173936262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5620	chr2	171573449	171573469	170716939	170716959	78202	hg19					enhancer	enh				GTGGTACTGCGCAAAGTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.720701496									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5621	chr2	171573469	171573489	170716959	170716979	78203	hg19					enhancer	enh				GCAGCGCGGCGATCTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073090345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5622	chr2	171573475	171573495	170716965	170716985	78204	hg19					enhancer	enh				GTCTGCAGCAGCGCGGCGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.337068652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5623	chr2	171573478	171573498	170716968	170716988	78205	hg19					enhancer	enh				GCGCCGCGCTGCTGCAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.053346584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5624	chr2	171573483	171573503	170716973	170716993	78206	hg19					enhancer	enh				GGCCTTGGTCTGCAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24996854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5625	chr2	171573487	171573507	170716977	170716997	78207	hg19					enhancer	enh				GCTGCAGACCAAGGCCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114703002									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5626	chr2	171573490	171573510	170716980	170717000	78208	hg19					enhancer	enh				GCAGACCAAGGCCCCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.278402428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5627	chr2	171573496	171573516	170716986	170717006	78209	hg19					enhancer	enh				GCAAGGCCCCCCTGGCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153328623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5628	chr2	171573501	171573521	170716991	170717011	78210	hg19					enhancer	enh				GCCCCCCTGGCGGCCACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.046890239									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5629	chr2	171573504	171573524	170716994	170717014	78211	hg19					enhancer	enh				GCCCTGGCGGCCACGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.548727826									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5630	chr2	171573504	171573524	170716994	170717014	78212	hg19					enhancer	enh				GCCTGGCCGTGGCCGCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012072288									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5631	chr2	171573505	171573525	170716995	170717015	78213	hg19					enhancer	enh				GTCCTGGCCGTGGCCGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040367653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5632	chr2	171573506	171573526	170716996	170717016	78214	hg19					enhancer	enh				GCTCCTGGCCGTGGCCGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.415806392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5633	chr2	171573507	171573527	170716997	170717017	78215	hg19					enhancer	enh				GCCTCCTGGCCGTGGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.307347268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5634	chr2	171573508	171573528	170716998	170717018	78216	hg19					enhancer	enh				GACCTCCTGGCCGTGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07895828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5635	chr2	171573516	171573536	170717006	170717026	78217	hg19					enhancer	enh				GCGGCGGCACCTCCTGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076360349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5636	chr2	171573522	171573542	170717012	170717032	78218	hg19					enhancer	enh				GCGGCAGCGGCGGCACCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.232285348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5637	chr2	171573535	171573555	170717025	170717045	78219	hg19					enhancer	enh				GCTGCCGCTGTCCCAACTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.105549443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5638	chr2	171573535	171573555	170717025	170717045	78220	hg19					enhancer	enh				GGCAGTTGGGACAGCGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.680199071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5639	chr2	171573538	171573558	170717028	170717048	78221	hg19					enhancer	enh				GCCGCTGTCCCAACTGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070232533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5640	chr2	171573541	171573561	170717031	170717051	78222	hg19					enhancer	enh				GCTGTCCCAACTGCCAGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.038328218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5641	chr2	171573541	171573561	170717031	170717051	78223	hg19					enhancer	enh				GCCGCCTGGCAGTTGGGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.271188295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5642	chr2	171573542	171573562	170717032	170717052	78224	hg19					enhancer	enh				GTGTCCCAACTGCCAGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.272126903									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5643	chr2	171573545	171573565	170717035	170717055	78225	hg19					enhancer	enh				GCCCAACTGCCAGGCGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082006469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5644	chr2	171573548	171573568	170717038	170717058	78226	hg19					enhancer	enh				GCCGCCCGCCGCCTGGCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.154731038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5645	chr2	171573549	171573569	170717039	170717059	78227	hg19					enhancer	enh				GCCGCCCGCCGCCTGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073040492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5646	chr2	171573565	171573585	170717055	170717075	78228	hg19					enhancer	enh				GCGGCGCCCCCGAGGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.296160055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5647	chr2	171573566	171573586	170717056	170717076	78229	hg19					enhancer	enh				GGCGCCCCCGAGGCGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.146493031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5648	chr2	171573567	171573587	170717057	170717077	78230	hg19					enhancer	enh				GCGCCCCCGAGGCGGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.304338338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5649	chr2	171573573	171573593	170717063	170717083	78231	hg19					enhancer	enh				GCTTCCCCGGCTCCGCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.022875516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5650	chr2	171573574	171573594	170717064	170717084	78232	hg19					enhancer	enh				GTCTTCCCCGGCTCCGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.211936732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5651	chr2	171573575	171573595	170717065	170717085	78233	hg19					enhancer	enh				GTTCTTCCCCGGCTCCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041764549									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5652	chr2	171573576	171573596	170717066	170717086	78234	hg19					enhancer	enh				GCTTCTTCCCCGGCTCCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085429267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5653	chr2	171573598	171573618	170717088	170717108	78235	hg19					enhancer	enh				GCAGCACGTGTGCCACGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040706566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5654	chr2	171573599	171573619	170717089	170717109	78236	hg19					enhancer	enh				GCAGCACGTGTGCCACGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.092862395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5655	chr2	171573605	171573625	170717095	170717115	78237	hg19					enhancer	enh				GTGTGCCACGTGCCGGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.067729569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5656	chr2	171573610	171573630	170717100	170717120	78238	hg19					enhancer	enh				GCCACGTGCCGGGCTGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062169159									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5657	chr2	171573613	171573633	170717103	170717123	78239	hg19					enhancer	enh				GCCTTGCCGCAGCCCGGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157528561									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5658	chr2	171573684	171573704	170717174	170717194	78240	hg19					enhancer	enh				GAGCGACCCTTCGTGTGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.414919105									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5659	chr2	171573696	171573716	170717186	170717206	78241	hg19					enhancer	enh				GTGTGCAACTGGCTCTTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.482586791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5660	chr2	171573715	171573735	170717205	170717225	78242	hg19					enhancer	enh				GCGGGAAGAGCTTCACGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257114545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5661	chr2	171573748	171573768	170717238	170717258	78243	hg19					enhancer	enh				GCGGCACCTGCGGACTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.460575691									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5662	chr2	171573749	171573769	170717239	170717259	78244	hg19					enhancer	enh				GCGGCACCTGCGGACTCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.179516214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5663	chr2	171573757	171573777	170717247	170717267	78245	hg19					enhancer	enh				GTCTCGCCCGTGTGAGTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.346610566									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5664	chr2	171573779	171573799	170717269	170717289	78246	hg19					enhancer	enh				GCGCTTTGCCTGTCCCGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.341826158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5665	chr2	171573789	171573809	170717279	170717299	78247	hg19					enhancer	enh				GCGCTTGCCGCACTCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.229367386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5666	chr2	171573794	171573814	170717284	170717304	78248	hg19					enhancer	enh				GATGAAGCGCTTGCCGCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.663663698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5667	chr2	171573795	171573815	170717285	170717305	78249	hg19					enhancer	enh				GCATGAAGCGCTTGCCGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.454860286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5668	chr2	171573826	171573846	170717316	170717336	78250	hg19					enhancer	enh				GTCTTGACGTGCTTCGCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124845881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5669	chr2	171573829	171573849	170717319	170717339	78251	hg19					enhancer	enh				GAGTCTTGACGTGCTTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208308557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5670	chr2	171573856	171573876	170717346	170717366	78252	hg19					enhancer	enh				GTAAGAAGCTCAAAGTCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236434949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5671	chr2	171573860	171573880	170717350	170717370	78253	hg19					enhancer	enh				GAAGCTCAAAGTCGCTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.499975359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5672	chr2	171573861	171573881	170717351	170717371	78254	hg19					enhancer	enh				GAGCTCAAAGTCGCTGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.244383802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5673	chr2	171573862	171573882	170717352	170717372	78255	hg19					enhancer	enh				GCTCAAAGTCGCTGAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.402551606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5674	chr2	171573870	171573890	170717360	170717380	78256	hg19					enhancer	enh				GTCGCTGAGGCCGGGGTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.514192879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5675	chr2	171573871	171573891	170717361	170717381	78257	hg19					enhancer	enh				GCGCTGAGGCCGGGGTTAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.12638827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5676	chr2	171573882	171573902	170717372	170717392	78258	hg19					enhancer	enh				GCGCGTCCTCCCGCTTAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.177564724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5677	chr2	171573883	171573903	170717373	170717393	78259	hg19					enhancer	enh				GGTTAAGCGGGAGGACGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.714141581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5678	chr2	171573901	171573921	170717391	170717411	78260	hg19					enhancer	enh				GCGGGACCTGTGAGCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.189874487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5679	chr2	171573904	171573924	170717394	170717414	78261	hg19					enhancer	enh				GGACCTGTGAGCCCTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005312762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5680	chr2	171573907	171573927	170717397	170717417	78262	hg19					enhancer	enh				GCCTGTGAGCCCTCCCGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.429107809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5681	chr2	171573910	171573930	170717400	170717420	78263	hg19					enhancer	enh				GCCACCTCCGGGAGGGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.369833761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5682	chr2	171573918	171573938	170717408	170717428	78264	hg19					enhancer	enh				GAAGGGGGTCCACCTCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093111418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5683	chr2	171573919	171573939	170717409	170717429	78265	hg19					enhancer	enh				GAAGGGGGTCCACCTCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.204817443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5684	chr2	171573922	171573942	170717412	170717432	78266	hg19					enhancer	enh				GTGGGAAGGGGGTCCACCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005836401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5685	chr2	171573923	171573943	170717413	170717433	78267	hg19					enhancer	enh				GCTGGGAAGGGGGTCCACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.589313556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5686	chr2	171573935	171573955	170717425	170717445	78268	hg19					enhancer	enh				GCTCGCAGAGGTGCTGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.462463897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5687	chr2	171573936	171573956	170717426	170717446	78269	hg19					enhancer	enh				GTCTCGCAGAGGTGCTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169150811									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5688	chr2	171573937	171573957	170717427	170717447	78270	hg19					enhancer	enh				GCTCTCGCAGAGGTGCTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.909010644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5689	chr2	171573940	171573960	170717430	170717450	78271	hg19					enhancer	enh				GCAGCACCTCTGCGAGAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.033446997									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5690	chr2	171573941	171573961	170717431	170717451	78272	hg19					enhancer	enh				GGATCTCTCGCAGAGGTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.26563739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5691	chr2	171573941	171573961	170717431	170717451	78273	hg19					enhancer	enh				GAGCACCTCTGCGAGAGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.206958418									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5692	chr2	171573942	171573962	170717432	170717452	78274	hg19					enhancer	enh				GCACCTCTGCGAGAGATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012968097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5693	chr2	171573942	171573962	170717432	170717452	78275	hg19					enhancer	enh				GCGGATCTCTCGCAGAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.330333302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5694	chr2	171573948	171573968	170717438	170717458	78276	hg19					enhancer	enh				GGTCCCCGGATCTCTCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.240718535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5695	chr2	171573950	171573970	170717440	170717460	78277	hg19					enhancer	enh				GCGAGAGATCCGGGGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073094179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5696	chr2	171573951	171573971	170717441	170717461	78278	hg19					enhancer	enh				GCGAGAGATCCGGGGACCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.44512409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5697	chr2	171573958	171573978	170717448	170717468	78279	hg19					enhancer	enh				GTCCGGGGACCTGTGGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.536987721									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5698	chr2	171573962	171573982	170717452	170717472	78280	hg19					enhancer	enh				GCCAGCTGCCCACAGGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171379692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5699	chr2	171573964	171573984	170717454	170717474	78281	hg19					enhancer	enh				GACCTGTGGGCAGCTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.143071955									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5700	chr2	171573965	171573985	170717455	170717475	78282	hg19					enhancer	enh				GACCTGTGGGCAGCTGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.466546017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5701	chr2	171573969	171573989	170717459	170717479	78283	hg19					enhancer	enh				GCCCCTCCGCCAGCTGCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.172632639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5702	chr2	171573981	171574001	170717471	170717491	78284	hg19					enhancer	enh				GCGGAGGGGAGACTCAGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.914096822									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5703	chr2	171574011	171574031	170717501	170717521	78285	hg19					enhancer	enh				GCCGTTGCCTGCCTCCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.433484975									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5704	chr2	171574018	171574038	170717508	170717528	78286	hg19					enhancer	enh				GCTGCCTCCCAAAATGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027002801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5705	chr2	171574028	171574048	170717518	170717538	78287	hg19					enhancer	enh				GTTGGAAGCCTGGCTCCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.047255235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5706	chr2	171574039	171574059	170717529	170717549	78288	hg19					enhancer	enh				GGCAGCGGAAGTTGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178836027									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5707	chr2	171574041	171574061	170717531	170717551	78289	hg19					enhancer	enh				GCTTCCAACTTCCGCTGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078183736									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5708	chr2	171574047	171574067	170717537	170717557	78290	hg19					enhancer	enh				GTGTCCGAAGGCAGCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.306407293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5709	chr2	171574048	171574068	170717538	170717558	78291	hg19					enhancer	enh				GCTTCCGCTGCCTTCGGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.162134722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5710	chr2	171574049	171574069	170717539	170717559	78292	hg19					enhancer	enh				GTTCCGCTGCCTTCGGACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084752779									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5711	chr2	171574054	171574074	170717544	170717564	78293	hg19					enhancer	enh				GTCCCTATGTCCGAAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.16296979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5712	chr2	171574060	171574080	170717550	170717570	78294	hg19					enhancer	enh				GAACTGGGTCCCTATGTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.02093663									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5713	chr2	171574063	171574083	170717553	170717573	78295	hg19					enhancer	enh				GACATAGGGACCCAGTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.498854052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5714	chr2	171574068	171574088	170717558	170717578	78296	hg19					enhancer	enh				GAGGGACCCAGTTCCCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.42962776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5715	chr2	171574069	171574089	170717559	170717579	78297	hg19					enhancer	enh				GGGACCCAGTTCCCAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057261629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5716	chr2	171574070	171574090	170717560	170717580	78298	hg19					enhancer	enh				GGACCCAGTTCCCAGGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.610116933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5717	chr2	171574073	171574093	170717563	170717583	78299	hg19					enhancer	enh				GCCCAGTTCCCAGGAGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108148399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5718	chr2	171574076	171574096	170717566	170717586	78300	hg19					enhancer	enh				GCCTCCCCGCTCCTGGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.647112381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5719	chr2	171574077	171574097	170717567	170717587	78301	hg19					enhancer	enh				GTTCCCAGGAGCGGGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.540696602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5720	chr2	171574077	171574097	170717567	170717587	78302	hg19					enhancer	enh				GACCTCCCCGCTCCTGGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.120857465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5721	chr2	171574078	171574098	170717568	170717588	78303	hg19					enhancer	enh				GTTCCCAGGAGCGGGGAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.767822211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5722	chr2	171574083	171574103	170717573	170717593	78304	hg19					enhancer	enh				GAACCCTACCTCCCCGCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.664953587									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5723	chr2	171574084	171574104	170717574	170717594	78305	hg19					enhancer	enh				GCAACCCTACCTCCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1841878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5724	chr2	171574128	171574148	170717618	170717638	78306	hg19					enhancer	enh				GTGGGAGCTCTGCCGTACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283941658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5725	chr2	171574129	171574149	170717619	170717639	78307	hg19					enhancer	enh				GGGAGCTCTGCCGTACGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.271156377									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5726	chr2	171574132	171574152	170717622	170717642	78308	hg19					enhancer	enh				GAGCTCTGCCGTACGCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.484329923									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5727	chr2	171574142	171574162	170717632	170717652	78309	hg19					enhancer	enh				GTTTGGAACCGCCCTGGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.717604846									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5728	chr2	171574149	171574169	170717639	170717659	78310	hg19					enhancer	enh				GTTTAGAGTTTGGAACCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.18024889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5729	chr2	171574160	171574180	170717650	170717670	78311	hg19					enhancer	enh				GGTGGGAACGGTTTAGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.171410701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5730	chr2	171574163	171574183	170717653	170717673	78312	hg19					enhancer	enh				GTCTAAACCGTTCCCACCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.771353178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5731	chr2	171574164	171574184	170717654	170717674	78313	hg19					enhancer	enh				GCTAAACCGTTCCCACCGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.325614036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5732	chr2	171574172	171574192	170717662	170717682	78314	hg19					enhancer	enh				GGTCTCCCTGACGGTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.313244386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5733	chr2	171574177	171574197	170717667	170717687	78315	hg19					enhancer	enh				GCTGTAGGTCTCCCTGACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.348485651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5734	chr2	171574178	171574198	170717668	170717688	78316	hg19					enhancer	enh				GACTGTAGGTCTCCCTGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.822785641									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5735	chr2	171574180	171574200	170717670	170717690	78317	hg19					enhancer	enh				GTCAGGGAGACCTACAGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012235162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5736	chr2	171574181	171574201	170717671	170717691	78318	hg19					enhancer	enh				GTCAGGGAGACCTACAGTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07394512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5737	chr2	171574181	171574201	170717671	170717691	78319	hg19					enhancer	enh				GAAACTGTAGGTCTCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151315338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5738	chr2	171574182	171574202	170717672	170717692	78320	hg19					enhancer	enh				GCAGGGAGACCTACAGTTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.496871381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5739	chr2	171574183	171574203	170717673	170717693	78321	hg19					enhancer	enh				GAGGGAGACCTACAGTTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044441318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5740	chr2	171574193	171574213	170717683	170717703	78322	hg19					enhancer	enh				GGGTGGTCCCCCGAAACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.007756111									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5741	chr2	171574193	171574213	170717683	170717703	78323	hg19					enhancer	enh				GACAGTTTCGGGGGACCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041575053									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5742	chr2	171574198	171574218	170717688	170717708	78324	hg19					enhancer	enh				GTTCGGGGGACCACCCTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.418718337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5743	chr2	171574210	171574230	170717700	170717720	78325	hg19					enhancer	enh				GTATACAAGGCCAGACCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.409751353									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5744	chr2	171574213	171574233	170717703	170717723	78326	hg19					enhancer	enh				GCTATATACAAGGCCAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.036517239									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5745	chr2	171574214	171574234	170717704	170717724	78327	hg19					enhancer	enh				GCCTATATACAAGGCCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.232242628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5746	chr2	171574224	171574244	170717714	170717734	78328	hg19					enhancer	enh				GAGCAGCATTTCCTATATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.085274453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5747	chr2	171574237	171574257	170717727	170717747	78329	hg19					enhancer	enh				GTGCTGCTGAACTGAATAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.147582334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5748	chr2	171574244	171574264	170717734	170717754	78330	hg19					enhancer	enh				GAACTGAATAGAAAGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057888534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5749	chr2	171574245	171574265	170717735	170717755	78331	hg19					enhancer	enh				GAACTGAATAGAAAGGAACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.977300068									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5750	chr2	171574265	171574285	170717755	170717775	78332	hg19					enhancer	enh				GGGAGATTTGAAACAGTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.377844539									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5751	chr2	171574266	171574286	170717756	170717776	78333	hg19					enhancer	enh				GGAGATTTGAAACAGTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.433353806									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5752	chr2	171574299	171574319	170717789	170717809	78334	hg19					enhancer	enh				GACCGGTTTGGGCTTTGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.03156495									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5753	chr2	171574304	171574324	170717794	170717814	78335	hg19					enhancer	enh				GAACCTGTACAAAGCCCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.159236441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5754	chr2	171574398	171574418	170717888	170717908	78336	hg19					enhancer	enh				GTATCATGCTGTAGCTCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.249836555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5755	chr2	171574450	171574470	170717940	170717960	78337	hg19					enhancer	enh				GAAAATAAATACTTTAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.499557499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5756	chr2	171574452	171574472	170717942	170717962	78338	hg19					enhancer	enh				GAAATAAATACTTTAACTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274584934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5757	chr2	171574462	171574482	170717952	170717972	78339	hg19					enhancer	enh				GTTTAACTCAGGGGTCACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.399097184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5758	chr2	171574480	171574500	170717970	170717990	78340	hg19					enhancer	enh				GACAGGAAGACCCCGTTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299041991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5759	chr2	171574492	171574512	170717982	170718002	78341	hg19					enhancer	enh				GCAAATGAGACCGGCTCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.700194078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5760	chr2	171574493	171574513	170717983	170718003	78342	hg19					enhancer	enh				GTCAAATGAGACCGGCTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.441851781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5761	chr2	171574494	171574514	170717984	170718004	78343	hg19					enhancer	enh				GATCAAATGAGACCGGCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.614834246									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5762	chr2	171574523	171574543	170718013	170718033	78344	hg19					enhancer	enh				GTTCTGGGTGGCTGTACTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078516929									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5763	chr2	171574527	171574547	170718017	170718037	78345	hg19					enhancer	enh				GGGTGGCTGTACTAAGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28241629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5764	chr2	171574528	171574548	170718018	170718038	78346	hg19					enhancer	enh				GGTGGCTGTACTAAGCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.696734872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5765	chr2	171574537	171574557	170718027	170718047	78347	hg19					enhancer	enh				GACTAAGCGGTCGGGTTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.04683255									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5766	chr2	171574538	171574558	170718028	170718048	78348	hg19					enhancer	enh				GCTAAGCGGTCGGGTTTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.215673462									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5767	chr2	171574548	171574568	170718038	170718058	78349	hg19					enhancer	enh				GGGTTTCCCCGGGAATTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186290297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5768	chr2	171574557	171574577	170718047	170718067	78350	hg19					enhancer	enh				GTAGGAACCATCAAATTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.6421821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5769	chr2	171574558	171574578	170718048	170718068	78351	hg19					enhancer	enh				GATAGGAACCATCAAATTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.437018565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5770	chr2	171574559	171574579	170718049	170718069	78352	hg19					enhancer	enh				GTATAGGAACCATCAAATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.392320494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5771	chr2	171574574	171574594	170718064	170718084	78353	hg19					enhancer	enh				GCTATAGTCTGCCTGTGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373122687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5772	chr2	171574576	171574596	170718066	170718086	78354	hg19					enhancer	enh				GCTCCGACACAGGCAGACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.154283516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5773	chr2	171574583	171574603	170718073	170718093	78355	hg19					enhancer	enh				GCCTGTGTCGGAGGCTTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.380966552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5774	chr2	171574587	171574607	170718077	170718097	78356	hg19					enhancer	enh				GACCAAAGAAGCCTCCGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.758855761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5775	chr2	171574611	171574631	170718101	170718121	78357	hg19					enhancer	enh				GAAGGATCTGGGCAAATGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.853948907									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5776	chr2	171574612	171574632	170718102	170718122	78358	hg19					enhancer	enh				GAGGATCTGGGCAAATGTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.475949812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5777	chr2	171574618	171574638	170718108	170718128	78359	hg19					enhancer	enh				GTGGGCAAATGTGTTGGGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.473987181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5778	chr2	171574623	171574643	170718113	170718133	78360	hg19					enhancer	enh				GAAATGTGTTGGGTTCAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.423366535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5779	chr2	171574630	171574650	170718120	170718140	78361	hg19					enhancer	enh				GTTGGGTTCAGGAATGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.410213884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5780	chr2	171574634	171574654	170718124	170718144	78362	hg19					enhancer	enh				GTTCAGGAATGGACAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.308301963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5781	chr2	171574665	171574685	170718155	170718175	78363	hg19					enhancer	enh				GCCTACCTCTTTACCACAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224264816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5782	chr2	171574698	171574718	170718188	170718208	78364	hg19					enhancer	enh				GTGAGAAACTCAAATTGTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049067035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5783	chr2	171574726	171574746	170718216	170718236	78365	hg19					enhancer	enh				GACAGTCTCGGGTGAATCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.347638141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5784	chr2	171574738	171574758	170718228	170718248	78366	hg19					enhancer	enh				GCTTGGAAGACAAACAGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.360899614									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5785	chr2	171574739	171574759	170718229	170718249	78367	hg19					enhancer	enh				GACTTGGAAGACAAACAGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056157856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5786	chr2	171574756	171574776	170718246	170718266	78368	hg19					enhancer	enh				GTCGTCAGGTAAAAACAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033241025									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5787	chr2	171574764	171574784	170718254	170718274	78369	hg19					enhancer	enh				GTTTACCTGACGAATTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220829153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5788	chr2	171574771	171574791	170718261	170718281	78370	hg19					enhancer	enh				GAAAGCCACAGGGAATTCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.234737222									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5789	chr2	171574782	171574802	170718272	170718292	78371	hg19					enhancer	enh				GCCAACAAATAGAAAGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.053300953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5790	chr2	171574783	171574803	170718273	170718293	78372	hg19					enhancer	enh				GACCAACAAATAGAAAGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.404237264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5791	chr2	171574809	171574829	170718299	170718319	78373	hg19					enhancer	enh				GGGACAGGTCACAACTATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022313835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5792	chr2	171574821	171574841	170718311	170718331	78374	hg19					enhancer	enh				GAACTATGCTGGTGTTAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046207415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5793	chr2	171574830	171574850	170718320	170718340	78375	hg19					enhancer	enh				GGTGTTAAGAGAGGTATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.259321244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5794	chr2	171574837	171574857	170718327	170718347	78376	hg19					enhancer	enh				GAGAGAGGTATTAGAGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.523684217									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5795	chr2	171574850	171574870	170718340	170718360	78377	hg19					enhancer	enh				GAGGCGCCAGGATCTGTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.149904516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5796	chr2	171574858	171574878	170718348	170718368	78378	hg19					enhancer	enh				GTCTCACCTGTGAACAGATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121321612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5797	chr2	171574863	171574883	170718353	170718373	78379	hg19					enhancer	enh				GTGTTCACAGGTGAGACTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264639808									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5798	chr2	171574868	171574888	170718358	170718378	78380	hg19					enhancer	enh				GACAGGTGAGACTTTGTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.898280402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5799	chr2	171574882	171574902	170718372	170718392	78381	hg19					enhancer	enh				GTGGAGAGGTACAGAGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.60457543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5800	chr2	171574895	171574915	170718385	170718405	78382	hg19					enhancer	enh				GAGAAACGGGACCCTTGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161355752									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5801	chr2	171574899	171574919	170718389	170718409	78383	hg19					enhancer	enh				GAACGGGACCCTTGTTCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.638364208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5802	chr2	171574909	171574929	170718399	170718419	78384	hg19					enhancer	enh				GCAAAGACCAACCTGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.389243146									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5803	chr2	171574910	171574930	170718400	170718420	78385	hg19					enhancer	enh				GGCAAAGACCAACCTGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.292029814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5804	chr2	171574943	171574963	170718433	170718453	78386	hg19					enhancer	enh				GCGTCTGGGAAACTATCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157365035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5805	chr2	171574958	171574978	170718448	170718468	78387	hg19					enhancer	enh				GAAATACAGGAGTGGCGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301234525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5806	chr2	171574959	171574979	170718449	170718469	78388	hg19					enhancer	enh				GTGAAATACAGGAGTGGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.206130197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5807	chr2	171574966	171574986	170718456	170718476	78389	hg19					enhancer	enh				GACGGGACTGAAATACAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.458532397									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5808	chr2	171574971	171574991	170718461	170718481	78390	hg19					enhancer	enh				GTCGTGACGGGACTGAAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.576203048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5809	chr2	171574984	171575004	170718474	170718494	78391	hg19					enhancer	enh				GACAACGCTGGCTATCGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334089791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5810	chr2	171574985	171575005	170718475	170718495	78392	hg19					enhancer	enh				GAACAACGCTGGCTATCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137018632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5811	chr2	171574997	171575017	170718487	170718507	78393	hg19					enhancer	enh				GAAAACAAGCAAAACAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452208966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5812	chr2	171575050	171575070	170718540	170718560	78394	hg19					enhancer	enh				GTTATTTCACAGTAACCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.075348133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5813	chr2	171575059	171575079	170718549	170718569	78395	hg19					enhancer	enh				GAGTAACCACCCAGGAATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.790510814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5814	chr2	171575064	171575084	170718554	170718574	78396	hg19					enhancer	enh				GCCACCCAGGAATTTCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048822402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5815	chr2	171575067	171575087	170718557	170718577	78397	hg19					enhancer	enh				GCCTAGCCAGAAATTCCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.711449775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5816	chr2	171575069	171575089	170718559	170718579	78398	hg19					enhancer	enh				GCAGGAATTTCTGGCTAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.306899272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5817	chr2	171575070	171575090	170718560	170718580	78399	hg19					enhancer	enh				GTGGCCTAGCCAGAAATTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.079178873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5818	chr2	171575071	171575091	170718561	170718581	78400	hg19					enhancer	enh				GCTGGCCTAGCCAGAAATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.244127707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5819	chr2	171575090	171575110	170718580	170718600	78401	hg19					enhancer	enh				GCAAAATGGAACTAAACGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.256206247									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5820	chr2	171575163	171575183	170718653	170718673	78402	hg19					enhancer	enh				GGAAGAGCCAGGAATACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324083151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5821	chr2	171575168	171575188	170718658	170718678	78403	hg19					enhancer	enh				GAGCCAGGAATACTCATGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.934962328									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5822	chr2	171575173	171575193	170718663	170718683	78404	hg19					enhancer	enh				GTTCCAAACCATGAGTATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.335711185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5823	chr2	171575176	171575196	170718666	170718686	78405	hg19					enhancer	enh				GATACTCATGGTTTGGAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.155643983									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5824	chr2	171575183	171575203	170718673	170718693	78406	hg19					enhancer	enh				GTGGTTTGGAAATGTGGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.208959875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5825	chr2	171575184	171575204	170718674	170718694	78407	hg19					enhancer	enh				GGTTTGGAAATGTGGAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.017290802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5826	chr2	171575321	171575341	170718811	170718831	78408	hg19					enhancer	enh				GCTGATAAAAGTTTCAGTTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.608534814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5827	chr2	171575441	171575461	170718931	170718951	78409	hg19					enhancer	enh				GACTATCATGAAAAGATTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.578371654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5828	chr2	171575461	171575481	170718951	170718971	78410	hg19					enhancer	enh				GTGAAGTGTGTACAAATTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.185396279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5829	chr2	171575518	171575538	170719008	170719028	78411	hg19					enhancer	enh				GTCAGTTTGACTTCAAACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.511104568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5830	chr2	171575639	171575659	170719129	170719149	78412	hg19					enhancer	enh				GAATAAAAATGCCATTTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.206181537									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5831	chr2	171575681	171575701	170719171	170719191	78413	hg19					enhancer	enh				GAATGAATATTAGATTCATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009066007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5832	chr2	171575709	171575729	170719199	170719219	78414	hg19					enhancer	enh				GTACCTTAGAATAAGAGATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.476990255									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5833	chr2	171575747	171575767	170719237	170719257	78415	hg19					enhancer	enh				GAATTAGAATGTGAGTCTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.313608583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5834	chr2	171575766	171575786	170719256	170719276	78416	hg19					enhancer	enh				GATGGTTCTTCACCTGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.21615045									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5835	chr2	171575773	171575793	170719263	170719283	78417	hg19					enhancer	enh				GTTCACCTGGGAAGAGGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.721572546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5836	chr2	171575780	171575800	170719270	170719290	78418	hg19					enhancer	enh				GTAACCCAAACTCCTCTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.116724393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5837	chr2	171575827	171575847	170719317	170719337	78419	hg19					enhancer	enh				GCAATAGTGATAAAGTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.280410237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5838	chr2	171575994	171576014	170719484	170719504	78420	hg19					enhancer	enh				GCTCCCATCTGAACCATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286283029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5839	chr2	171575995	171576015	170719485	170719505	78421	hg19					enhancer	enh				GTCCCATCTGAACCATGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.10141423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5840	chr2	171575999	171576019	170719489	170719509	78422	hg19					enhancer	enh				GTCCCAGGGCATGGTTCAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.04621689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5841	chr2	171576000	171576020	170719490	170719510	78423	hg19					enhancer	enh				GATCCCAGGGCATGGTTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.447144504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5842	chr2	171576009	171576029	170719499	170719519	78424	hg19					enhancer	enh				GCTATAGTTGATCCCAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.696261084									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5843	chr2	171576014	171576034	170719504	170719524	78425	hg19					enhancer	enh				GTGAATCTATAGTTGATCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301155586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5844	chr2	171576015	171576035	170719505	170719525	78426	hg19					enhancer	enh				GCTGAATCTATAGTTGATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214780216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5845	chr2	171576018	171576038	170719508	170719528	78427	hg19					enhancer	enh				GATCAACTATAGATTCAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.957767835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5846	chr2	171576044	171576064	170719534	170719554	78428	hg19					enhancer	enh				GTTTGGAAAGTGGTGAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.51623977									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96898	chr2	171576127	171576147	170719617	170719637	78429	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTCATCTGAAAGAATGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.76167441	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576208	171576228	170719698	170719718	78430	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTGGATACTAAATAAATGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070711093	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576215	171576235	170719705	170719725	78431	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATTTAGTATCCAAACAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.109777786	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576293	171576313	170719783	170719803	78432	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTATCTAAGGAAATGAGATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.713693742	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576309	171576329	170719799	170719819	78433	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATATTGGAGATAGATAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060920734	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576388	171576408	170719878	170719898	78434	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATGACAAAATAACTTTGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0711385	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576425	171576445	170719915	170719935	78435	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GACCTGCAAATTGAAAAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.366271956	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576437	171576457	170719927	170719947	78436	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAAAAGTATGGTCTTTAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019475537	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576450	171576470	170719940	170719960	78437	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTTAACGTGGTACAGCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.364338685	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576482	171576502	170719972	170719992	78438	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGTACCACTGCAAATCTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136812979	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576489	171576509	170719979	170719999	78439	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCAATCCTATCAGATTTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216674914	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576521	171576541	170720011	170720031	78440	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTCTGACAACATTAAAGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083805045	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576564	171576584	170720054	170720074	78441	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTAATCCACCAACTTTATTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.231794367	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576571	171576591	170720061	170720081	78442	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAACCTTGAATAAAGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.174147313	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576574	171576594	170720064	170720084	78443	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGTGAAACCTTGAATAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084804603	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576654	171576674	170720144	170720164	78444	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGATTGCCTCAAATGTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.182180117	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576663	171576683	170720153	170720173	78445	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GACAATGCCTACTGACATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.131215517	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576788	171576808	170720278	170720298	78446	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTCCAAGTTCTTGCTCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.146272912	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171576791	171576811	170720281	170720301	78447	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGAGCAAGAACTTGGAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327948841	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577001	171577021	170720491	170720511	78448	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTGAAACTAGAAAATAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253350496	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577356	171577376	170720846	170720866	78449	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGAATATACAATATACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.189242462	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577357	171577377	170720847	170720867	78450	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAGAATATACAATATACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.338264368	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577434	171577454	170720924	170720944	78451	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTTCTGCAAGAGGCATGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199194735	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577443	171577463	170720933	170720953	78452	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTCAAATAGGTTTCTGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.049790775	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577499	171577519	170720989	170721009	78453	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATAAAAAATAGTACAGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.227067315	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577500	171577520	170720990	170721010	78454	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAATAAAAAATAGTACAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.035725521	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577501	171577521	170720991	170721011	78455	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAATAAAAAATAGTACAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.038274283	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577685	171577705	170721175	170721195	78456	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGAGCTAATGCAAGTAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.218372727	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577708	171577728	170721198	170721218	78457	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCATTAAATAATGACTAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145388991	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577729	171577749	170721219	170721239	78458	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GGTAAGTTGCCCATTCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.069633638	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577730	171577750	170721220	170721240	78459	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTAAGTTGCCCATTCTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.058354507	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577741	171577761	170721231	170721251	78460	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GACTATTTCCCAGTGAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196861448	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577742	171577762	170721232	170721252	78461	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGACTATTTCCCAGTGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.255075765	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577820	171577840	170721310	170721330	78462	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTGCTAATGTCGCAAATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.581349768	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577889	171577909	170721379	170721399	78463	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTCTCTATCATGCAAACCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043078429	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577898	171577918	170721388	170721408	78464	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCATGATAGAGAGAACTTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.2169163	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577913	171577933	170721403	170721423	78465	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTTAAAGGAGTATGAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.072098039	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577914	171577934	170721404	170721424	78466	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTAAAGGAGTATGAGACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.421138425	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577933	171577953	170721423	170721443	78467	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGACATTTCAAAACTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138992574	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577934	171577954	170721424	170721444	78468	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATGACATTTCAAAACTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207066571	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171577957	171577977	170721447	170721467	78469	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCCAACATAGTTCAATAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056772828	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578047	171578067	170721537	170721557	78470	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAAAGAACATGTTTCATTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.646692109	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578060	171578080	170721550	170721570	78471	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTCATTATTGGGCCACTATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.642957085	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578074	171578094	170721564	170721584	78472	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTAATCAGGTTACCATTATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.28979415	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578077	171578097	170721567	170721587	78473	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTAATGGTAACCTGATTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183617857	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578089	171578109	170721579	170721599	78474	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAATCACATGCCACACTAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.198407163	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578191	171578211	170721681	170721701	78475	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTCTTTAAAAATAATCAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.753233817	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578227	171578247	170721717	170721737	78476	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATCTGAAACATTGCTGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.724422344	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578315	171578335	170721805	170721825	78477	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAGATGTAATCAAACAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.640371787	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578381	171578401	170721871	170721891	78478	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATCATGTACAAATCTTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055918691	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578440	171578460	170721930	170721950	78479	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAGTGCATAAAGTCTAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.75251418	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578441	171578461	170721931	170721951	78480	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAAGTGCATAAAGTCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.453944162	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578469	171578489	170721959	170721979	78481	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTAGATAATTGCTAAAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.203461896	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578500	171578520	170721990	170722010	78482	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAGTCTCAAATATCCAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.215680279	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578579	171578599	170722069	170722089	78483	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCCACATTAACTAATACATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.593370248	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578582	171578602	170722072	170722092	78484	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCCAAAATGTATTAGTTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.35979659	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578610	171578630	170722100	170722120	78485	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCTCATACCAAAATGTAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.510458772	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578611	171578631	170722101	170722121	78486	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTCATACCAAAATGTAATTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.715867629	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578645	171578665	170722135	170722155	78487	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGGTATCAAACTAAGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.182086766	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578646	171578666	170722136	170722156	78488	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGTGGTATCAAACTAAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286727635	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578730	171578750	170722220	170722240	78489	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GACAAACTTCCATTTCATAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084571885	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578868	171578888	170722358	170722378	78490	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGAGTTAAACCAGTCATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.626109416	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578869	171578889	170722359	170722379	78491	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGTTAAACCAGTCATATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.533058203	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578880	171578900	170722370	170722390	78492	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGAAAGCACCCATATATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04786017	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578915	171578935	170722405	170722425	78493	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAGCATAATCTAAAACACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.187209926	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578926	171578946	170722416	170722436	78494	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAACACAGATGGAAAACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				2.022145247	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578953	171578973	170722443	170722463	78495	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAATTGGGTAAAATTAAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.353535244	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171578969	171578989	170722459	170722479	78496	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAATTCATGAAGCAAATATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.385218594	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579081	171579101	170722571	170722591	78497	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATAAGAGAAATGAGCTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134645335	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579151	171579171	170722641	170722661	78498	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTGACATCCACAAGTCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.243964	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579184	171579204	170722674	170722694	78499	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATCCATGTCCATTTCTAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108121731	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579189	171579209	170722679	170722699	78500	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTCCATGCTAGAAATGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.380453025	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579195	171579215	170722685	170722705	78501	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GAAAGTTTCCATGCTAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.286944286	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579238	171579258	170722728	170722748	78502	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GATAAATACGTTGAGAAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.411847267	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579263	171579283	170722753	170722773	78503	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTGGGAGCAAAATCAAATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101990746	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579279	171579299	170722769	170722789	78504	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GCCAATAATGCGGAACTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.556647339	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-96898	chr2	171579545	171579565	170723035	170723055	78505	hg19	N/A	N/A	N/A	Enhatls103714	enhancer	enh				GTTGAGACCAGCTGGCCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.015439021	SP5	chr2	170715336	170718078	1528				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8824
enhrx-lit5847	chr2	171579760	171579780	170723250	170723270	78506	hg19					enhancer	enh				GTGTGAATTTGTGAACATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099293211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5848	chr2	171579761	171579781	170723251	170723271	78507	hg19					enhancer	enh				GTGAATTTGTGAACATCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.430163974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5849	chr2	171579761	171579781	170723251	170723271	78508	hg19					enhancer	enh				GACTGATGTTCACAAATTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.216451709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5850	chr2	171579773	171579793	170723263	170723283	78509	hg19					enhancer	enh				GACATCAGTGGGAAAAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.460372474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5851	chr2	171579812	171579832	170723302	170723322	78510	hg19					enhancer	enh				GTAAAATACAGTAGAAGATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.28176816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5852	chr2	171579819	171579839	170723309	170723329	78511	hg19					enhancer	enh				GCAGTAGAAGATTATGGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.335690435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5853	chr2	171579833	171579853	170723323	170723343	78512	hg19					enhancer	enh				GGTTTGAGGTAATACCAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.097698082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5854	chr2	171579850	171579870	170723340	170723360	78513	hg19					enhancer	enh				GTTGCTAAAATCTATCCAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.627487326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5855	chr2	171579906	171579926	170723396	170723416	78514	hg19					enhancer	enh				GAAAGGGCTGTTTAATGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.036156653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5856	chr2	171579907	171579927	170723397	170723417	78515	hg19					enhancer	enh				GTAAAGGGCTGTTTAATGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111341087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5857	chr2	171580015	171580035	170723505	170723525	78516	hg19					enhancer	enh				GAAAAACAAGTCTCCATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.455151204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5858	chr2	171580045	171580065	170723535	170723555	78517	hg19					enhancer	enh				GGATCAAACAGGGGAGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.38149581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5859	chr2	171580054	171580074	170723544	170723564	78518	hg19					enhancer	enh				GGACTTCAAGGATCAAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.098324682									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5860	chr2	171580055	171580075	170723545	170723565	78519	hg19					enhancer	enh				GTGGACTTCAAGGATCAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.620298707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5861	chr2	171580056	171580076	170723546	170723566	78520	hg19					enhancer	enh				GATGGACTTCAAGGATCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.707537251									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5862	chr2	171580066	171580086	170723556	170723576	78521	hg19					enhancer	enh				GAAGAGATGACATGGACTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.827587041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5863	chr2	171580075	171580095	170723565	170723585	78522	hg19					enhancer	enh				GAGTACTATCAAGAGATGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.572236961									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96899	chr2	171580101	171580121	170723591	170723611	78523	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGCTGCCAAGAAAGTCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.255452868	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580125	171580145	170723615	170723635	78524	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGAAATTCTGTAGTGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.539267662	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580126	171580146	170723616	170723636	78525	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGAAATTCTGTAGTGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176348864	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580146	171580166	170723636	170723656	78526	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAACTTTCTACTTCAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075751217	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580169	171580189	170723659	170723679	78527	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCTCTCCCTAGAAAACAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.669003547	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580197	171580217	170723687	170723707	78528	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCTGAATCATGACTGATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152405333	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580198	171580218	170723688	170723708	78529	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCTGAATCATGACTGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.067914324	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580235	171580255	170723725	170723745	78530	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTGGCTGCTCAGGGCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.349703744	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580241	171580261	170723731	170723751	78531	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCTGAGCAGCCAGCAGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.339594071	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580243	171580263	170723733	170723753	78532	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTCTAGCTGCTGGCTGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.144376012	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580244	171580264	170723734	170723754	78533	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCTCTAGCTGCTGGCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.511104463	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580247	171580267	170723737	170723757	78534	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGCCAGCAGCTAGAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.034231065	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580248	171580268	170723738	170723758	78535	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGCCAGCAGCTAGAGGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.07434026	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580249	171580269	170723739	170723759	78536	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCAGCAGCTAGAGGCTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.109887762	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580253	171580273	170723743	170723763	78537	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCCCACAGCCTCTAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191494338	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580273	171580293	170723763	170723783	78538	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGTGGCTGCCCCCTTGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.000291284	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580279	171580299	170723769	170723789	78539	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGCCCCCTTGCTTCTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.171753552	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580280	171580300	170723770	170723790	78540	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCCCCTTGCTTCTGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26782809	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580283	171580303	170723773	170723793	78541	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCCTTGCTTCTGGAGCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19959187	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580284	171580304	170723774	170723794	78542	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCCCTGCTCCAGAAGCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.738522401	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580285	171580305	170723775	170723795	78543	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTCCCTGCTCCAGAAGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.924608107	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580286	171580306	170723776	170723796	78544	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCTCCCTGCTCCAGAAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016851915	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580287	171580307	170723777	170723797	78545	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GACCTCCCTGCTCCAGAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.508208256	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580289	171580309	170723779	170723799	78546	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTTCTGGAGCAGGGAGGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023796767	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580302	171580322	170723792	170723812	78547	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGTCTAGGAGTAAAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.026928439	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580303	171580323	170723793	170723813	78548	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGTCTAGGAGTAAAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.666941128	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580329	171580349	170723819	170723839	78549	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAAATGGGGAATAACAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.723864387	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580350	171580370	170723840	170723860	78550	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGAGAATATCCTATCTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034823673	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580361	171580381	170723851	170723871	78551	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTATCTAAACAGGATATCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.495828876	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580362	171580382	170723852	170723872	78552	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATCTAAACAGGATATCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273879377	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580363	171580383	170723853	170723873	78553	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCTAAACAGGATATCAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.978983704	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580373	171580393	170723863	170723883	78554	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATATCAAAAGGGGTTGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.34830271	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580374	171580394	170723864	170723884	78555	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTATCAAAAGGGGTTGAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167316608	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580383	171580403	170723873	170723893	78556	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGGTTGAAATAGGGTCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.620061491	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580397	171580417	170723887	170723907	78557	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCATTTAGGTAGAAGTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.719995238	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580402	171580422	170723892	170723912	78558	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTAGGTAGAAGTAGAAAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.106100066	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580430	171580450	170723920	170723940	78559	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCACCTTCTCAAATTTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114385254	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580436	171580456	170723926	170723946	78560	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGTCCATTTCAAATTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027370856	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580438	171580458	170723928	170723948	78561	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCAAATTTGAAATGGACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.544751788	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580442	171580462	170723932	170723952	78562	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATTTGAAATGGACCCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.017420038	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580446	171580466	170723936	170723956	78563	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAATGGACCCCAGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.804680779	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580457	171580477	170723947	170723967	78564	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGGAGGCACCTTCCTTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.306733034	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580458	171580478	170723948	170723968	78565	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGGAGGCACCTTCCTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.45490417	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580459	171580479	170723949	170723969	78566	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGGAGGCACCTTCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.671346477	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580464	171580484	170723954	170723974	78567	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGGTGCCTCCCTCACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056649019	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580474	171580494	170723964	170723984	78568	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCCAAAAACCTGGGGTGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.458085098	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580477	171580497	170723967	170723987	78569	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATTCCAAAAACCTGGGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.421685628	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580478	171580498	170723968	170723988	78570	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAATTCCAAAAACCTGGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137531617	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580483	171580503	170723973	170723993	78571	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCACAAAATTCCAAAAACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.306735454	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580526	171580546	170724016	170724036	78572	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAACTAAAGGTGAGTATGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101969188	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580535	171580555	170724025	170724045	78573	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGAGTATGAGTAGGCTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.06188062	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580543	171580563	170724033	170724053	78574	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGTAGGCTGTAGAGGAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.694882016	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580563	171580583	170724053	170724073	78575	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGGTGGACTTTAACGACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.544728789	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580582	171580602	170724072	170724092	78576	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTAAGGATAATTCAAGTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.218258422	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580600	171580620	170724090	170724110	78577	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGCTTTGGAAGAGACCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.683698771	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580886	171580906	170724376	170724396	78578	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATTATTACATGTAGGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.059232497	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580954	171580974	170724444	170724464	78579	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTTTGAAGTCTACAAGATGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.293633323	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171580964	171580984	170724454	170724474	78580	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GACAAGATGTAAGGTACAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.526825483	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581010	171581030	170724500	170724520	78581	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAAAGAGCTCACAGTCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.651470074	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581024	171581044	170724514	170724534	78582	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCACAAAGGAGATAAAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310139803	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581046	171581066	170724536	170724556	78583	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCACAAATGAATGTAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.195634537	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581096	171581116	170724586	170724606	78584	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAACTCCTCTAAAAACACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.17690297	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581167	171581187	170724657	170724677	78585	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAAAGCAGAATATCCATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.203567337	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581192	171581212	170724682	170724702	78586	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAATCTCCAAACTGCATCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.584921674	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581201	171581221	170724691	170724711	78587	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGAATGCCACAGATGCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.318292039	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581228	171581248	170724718	170724738	78588	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTCTGAATAAAAATCTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.483453633	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581244	171581264	170724734	170724754	78589	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGCTGTTAGTTCAAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280697761	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581285	171581305	170724775	170724795	78590	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGCATCACTTGGGAATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156900046	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581333	171581353	170724823	170724843	78591	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATTTAGTAAGTCTGGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59248754	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581352	171581372	170724842	170724862	78592	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGAAACCCTGAGAACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.329202666	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581361	171581381	170724851	170724871	78593	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGATTGCCAGGCCGTTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.656919052	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581362	171581382	170724852	170724872	78594	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGATTGCCAGGCCGTTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.812189797	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581435	171581455	170724925	170724945	78595	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCGTGCAGTTTCCTAAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.211489371	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581528	171581548	170725018	170725038	78596	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAATAGAAAATGGATAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.187092984	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581533	171581553	170725023	170725043	78597	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGAAAATGGATAGACTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432581674	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581853	171581873	170725343	170725363	78598	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGAAAATGGATAGACCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.003107387	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581871	171581891	170725361	170725381	78599	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGGTGAGAATTTCAGCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.186427995	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581883	171581903	170725373	170725393	78600	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTCTCACCCAATTGAGAATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.466507361	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581884	171581904	170725374	170725394	78601	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTCACCCAATTGAGAATATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.224664902	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581891	171581911	170725381	170725401	78602	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGAGCCCAATATTCTCAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138319415	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581892	171581912	170725382	170725402	78603	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTAGAGCCCAATATTCTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.542377899	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171581958	171581978	170725448	170725468	78604	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAATTACATAACATGCATGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.208701947	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582014	171582034	170725504	170725524	78605	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAAAAATGTAAATACTGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207368936	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582075	171582095	170725565	170725585	78606	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGTCACTGTTCGACTTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.142253724	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582076	171582096	170725566	170725586	78607	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGTCACTGTTCGACTTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.190467319	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582077	171582097	170725567	170725587	78608	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAAGTCACTGTTCGACTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.259147201	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582086	171582106	170725576	170725596	78609	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GACAGTGACTTTAGCAATATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.565500298	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582098	171582118	170725588	170725608	78610	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAATATCTGGTTTCCTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055474678	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582230	171582250	170725720	170725740	78611	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGCTGCAGAAATGCAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28156181	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582281	171582301	170725771	170725791	78612	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGTAGCAAAACAGAGGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432387478	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582284	171582304	170725774	170725794	78613	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTACTGTAGCAAAACAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400366317	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582288	171582308	170725778	170725798	78614	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGCTACTGTAGCAAAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.598808322	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582313	171582333	170725803	170725823	78615	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAACTACCCACAGGGAAATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009384453	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582320	171582340	170725810	170725830	78616	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCACAGGGAAATGTAGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.110888933	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582321	171582341	170725811	170725831	78617	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGCTCCTACATTTCCCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021901566	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582322	171582342	170725812	170725832	78618	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGGCTCCTACATTTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.445052882	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582341	171582361	170725831	170725851	78619	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTGTACTACAGAGAAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15883985	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582355	171582375	170725845	170725865	78620	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTACACATGAAAACCTTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.399994614	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582361	171582381	170725851	170725871	78621	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GATGAAAACCTTAGAAGGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.22414432	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582371	171582391	170725861	170725881	78622	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GTAAATATCCACAACCTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183271123	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582398	171582418	170725888	170725908	78623	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAAGAATGTTCACTTTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.51086729	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582400	171582420	170725890	170725910	78624	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCAGAGGAAAGTGAACATTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.241949637	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582417	171582437	170725907	170725927	78625	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGGATTGGGCTAGAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.494661308	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582419	171582439	170725909	170725929	78626	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GGTTCTAGCCCAATCCTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.472688821	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582430	171582450	170725920	170725940	78627	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAGGTGGACCAATGAGGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.43704629	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582431	171582451	170725921	170725941	78628	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAAAGGTGGACCAATGAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091999577	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582436	171582456	170725926	170725946	78629	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGAAAAAAGGTGGACCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.353067922	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582459	171582479	170725949	170725969	78630	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GAGCAAGAAAGACTTTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.168647269	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-96899	chr2	171582472	171582492	170725962	170725982	78631	hg19	N/A	N/A	N/A	Enhatls103715	enhancer	enh				GCTTGCTCAAAGTGCATTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.226528376	SP5	chr2	170715336	170718078	5513				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8825
enhrx-lit5864	chr2	171582554	171582574	170726044	170726064	78632	hg19					enhancer	enh				GTTGGAATTGTAGAAAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.537742724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5865	chr2	171582554	171582574	170726044	170726064	78633	hg19					enhancer	enh				GCAGCTTTCTACAATTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.526546607									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5866	chr2	171582555	171582575	170726045	170726065	78634	hg19					enhancer	enh				GTGGAATTGTAGAAAGCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.258873568									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5867	chr2	171582571	171582591	170726061	170726081	78635	hg19					enhancer	enh				GTGCTGGGAATTACCAGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045271867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5868	chr2	171582572	171582592	170726062	170726082	78636	hg19					enhancer	enh				GCTGGGAATTACCAGTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.157615517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96900	chr2	171582586	171582606	170726076	170726096	78637	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTTACAGGTTTCCCTGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.065764198	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582663	171582683	170726153	170726173	78638	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTAGACTTGGGGGCAGAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.958315636	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582664	171582684	170726154	170726174	78639	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTTAGACTTGGGGGCAGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.618337172	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582713	171582733	170726203	170726223	78640	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTCACTAGGGAGGCCTCCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086617351	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582729	171582749	170726219	170726239	78641	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTGAACAATAACAAGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.528937485	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582758	171582778	170726248	170726268	78642	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCTGACTGTAGCATATTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23697089	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582761	171582781	170726251	170726271	78643	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACTGTAGCATATTCCCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.08206926	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582777	171582797	170726267	170726287	78644	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTCAGGGATTGGGGCCTCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.757515699	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582778	171582798	170726268	170726288	78645	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCTCAGGGATTGGGGCCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.365947146	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582784	171582804	170726274	170726294	78646	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCCCAATCCCTGAGAGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.408793198	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582785	171582805	170726275	170726295	78647	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCCAATCCCTGAGAGATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.299496706	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582787	171582807	170726277	170726297	78648	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCTTGATCTCTCAGGGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.212284794	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582788	171582808	170726278	170726298	78649	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCCTTGATCTCTCAGGGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39773075	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582789	171582809	170726279	170726299	78650	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTCCCTTGATCTCTCAGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238920722	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582794	171582814	170726284	170726304	78651	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGAGCTCCCTTGATCTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15962221	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582795	171582815	170726285	170726305	78652	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGAGCTCCCTTGATCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.411049844	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582843	171582863	170726333	170726353	78653	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACTTACAGAATTTAGCATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.906614982	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582849	171582869	170726339	170726359	78654	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGAATTTAGCATGTTGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033907059	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582875	171582895	170726365	170726385	78655	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCTTAAAAATCACCGACTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.376760056	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582879	171582899	170726369	170726389	78656	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAAAATCACCGACTCTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.248696016	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582880	171582900	170726370	170726390	78657	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAAATCACCGACTCTGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.089901483	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171582889	171582909	170726379	170726399	78658	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACCGTGCCCAGCCTCAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049286929	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583279	171583299	170726769	170726789	78659	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCTTACTTGTGTAATGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.079698208	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583288	171583308	170726778	170726798	78660	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCACAAGTAAGCACATTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157955987	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583309	171583329	170726799	170726819	78661	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GGAATCCAGCAGCCTAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.27247282	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583310	171583330	170726800	170726820	78662	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAATCCAGCAGCCTAGCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.475119396	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583317	171583337	170726807	170726827	78663	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCTCTCCCTTTGCTAGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06065017	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583318	171583338	170726808	170726828	78664	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCAGCCTAGCAAAGGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327743544	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583324	171583344	170726814	170726834	78665	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGCAAAGGGAGAGATGGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15396732	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583324	171583344	170726814	170726834	78666	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCAACCATCTCTCCCTTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.003288371	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583350	171583370	170726840	170726860	78667	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GATAGAGACTGAGAGAAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.626509076	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583361	171583381	170726851	170726871	78668	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGAAGACTCGGAAGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217206132	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583374	171583394	170726864	170726884	78669	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGAAGTATGGAGAGAAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.610924558	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583402	171583422	170726892	170726912	78670	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGTTGCCAAAGTACTAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.067988845	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583405	171583425	170726895	170726915	78671	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTGCCAAAGTACTAAGAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.76709807	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583410	171583430	170726900	170726920	78672	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAGCCACCATTCTTAGTACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200468709	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583439	171583459	170726929	170726949	78673	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTTACATGCATGAAAATTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.337533021	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583456	171583476	170726946	170726966	78674	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACCTGGGATGCTTATTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.332220862	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583460	171583480	170726950	170726970	78675	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTCCATTTAAATAAGCATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.22244206	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583487	171583507	170726977	170726997	78676	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCAGTTCTAGGGATGTAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245430088	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583497	171583517	170726987	170727007	78677	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCTAGAACTGCTAATTCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.14251996	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583499	171583519	170726989	170727009	78678	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCAAACGAATTAGCAGTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.57813255	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583500	171583520	170726990	170727010	78679	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCAAACGAATTAGCAGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.68706358	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583555	171583575	170727045	170727065	78680	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCACCCCAGTGACTCTAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.237330747	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583558	171583578	170727048	170727068	78681	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCCAGTGACTCTAAGACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161348459	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583560	171583580	170727050	170727070	78682	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCACCTGTCTTAGAGTCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15447584	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583561	171583581	170727051	170727071	78683	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCCACCTGTCTTAGAGTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08899578	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583562	171583582	170727052	170727072	78684	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTGACTCTAAGACAGGTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.86399001	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583562	171583582	170727052	170727072	78685	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACCACCTGTCTTAGAGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.123410639	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583595	171583615	170727085	170727105	78686	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTAAGGAAGCATTTCTCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152865747	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583613	171583633	170727103	170727123	78687	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACAAGAGAAAACCTAGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167572709	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583615	171583635	170727105	170727125	78688	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAAGAGAAAACCTAGTGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.4810424	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583627	171583647	170727117	170727137	78689	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTAGATGTTACCCCATTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.399562312	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583652	171583672	170727142	170727162	78690	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTTTGACAACGGCAAATGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.177974756	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583707	171583727	170727197	170727217	78691	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GAAGTCCACAGCTGATTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.5697254	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583714	171583734	170727204	170727224	78692	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GCAGACCTCAGCAATCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.282221043	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583740	171583760	170727230	170727250	78693	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GTATATTCCATGATCTCGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.114821339	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-96900	chr2	171583749	171583769	170727239	170727259	78694	hg19	N/A	N/A	N/A	Enhatls103716	enhancer	enh				GACTTCTCCTCTTCGAGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39167067	SP5	chr2	170715336	170718078	8013				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8826
enhrx-lit5869	chr2	171583796	171583816	170727286	170727306	78695	hg19					enhancer	enh				GACAGCATTTGGCACAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.403841004									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5870	chr2	171583808	171583828	170727298	170727318	78696	hg19					enhancer	enh				GATGACATCTACTACAGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409123871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5871	chr2	171583856	171583876	170727346	170727366	78697	hg19					enhancer	enh				GAAAGACACTAAATGATCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136230935									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5872	chr2	171583857	171583877	170727347	170727367	78698	hg19					enhancer	enh				GAAGACACTAAATGATCACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139667737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5873	chr2	171583991	171584011	170727481	170727501	78699	hg19					enhancer	enh				GTTCAGAATCAGAGTCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150240793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5874	chr2	171584024	171584044	170727514	170727534	78700	hg19					enhancer	enh				GGTGAACTCTGAAATCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.559377536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5875	chr2	171584045	171584065	170727535	170727555	78701	hg19					enhancer	enh				GTACAATAAAGAGGCTTGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124967832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5876	chr2	171584055	171584075	170727545	170727565	78702	hg19					enhancer	enh				GCTTCATCTGTACAATAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.418782559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5877	chr2	171584070	171584090	170727560	170727580	78703	hg19					enhancer	enh				GAAGCAACCAATACTCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.017406787									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5878	chr2	171584080	171584100	170727570	170727590	78704	hg19					enhancer	enh				GGCTGGACCTTGATGAGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.328033109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5879	chr2	171584152	171584172	170727642	170727662	78705	hg19					enhancer	enh				GAGAGGTAAGATATCAGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.526069925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5880	chr2	171584153	171584173	170727643	170727663	78706	hg19					enhancer	enh				GAAGAGGTAAGATATCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.95728356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5881	chr2	171584158	171584178	170727648	170727668	78707	hg19					enhancer	enh				GTGATAAAGAGGTAAGATATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.026062656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5882	chr2	171584170	171584190	170727660	170727680	78708	hg19					enhancer	enh				GAAGTGAATGGAATGATAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.23947097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5883	chr2	171584183	171584203	170727673	170727693	78709	hg19					enhancer	enh				GTACATGAATCTAAAAGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59388855									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5884	chr2	171584250	171584270	170727740	170727760	78710	hg19					enhancer	enh				GCATCATGAAAAAGTCATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.76550023									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5885	chr2	171584265	171584285	170727755	170727775	78711	hg19					enhancer	enh				GATACAAGGTTCTTGCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.208239899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5886	chr2	171584271	171584291	170727761	170727781	78712	hg19					enhancer	enh				GGTTCTTGCTGTCACGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.578087068									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5887	chr2	171584303	171584323	170727793	170727813	78713	hg19					enhancer	enh				GAAGAAATACAGAACGTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016859211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5888	chr2	171584314	171584334	170727804	170727824	78714	hg19					enhancer	enh				GAACGTTGACAGGAAATATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076682639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96901	chr2	171584323	171584343	170727813	170727833	78715	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGAAATATTTAGGAACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.531792622	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584333	171584353	170727823	170727843	78716	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGAACATCAGGAGAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022820442	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584354	171584374	170727844	170727864	78717	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGCTATTCACTACCACATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.072720134	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584373	171584393	170727863	170727883	78718	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGGAGCCTAATATAATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.279377521	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584429	171584449	170727919	170727939	78719	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATATAAGGTACTACAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.131694005	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584472	171584492	170727962	170727982	78720	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACTACCAGTTAAAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				2.404989568	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584494	171584514	170727984	170728004	78721	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCCCATTGGCATCTATAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.43731019	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584497	171584517	170727987	170728007	78722	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCATTGGCATCTATAAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07388613	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584498	171584518	170727988	170728008	78723	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATTGGCATCTATAAGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280467283	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584499	171584519	170727989	170728009	78724	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACCTCTTATAGATGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034216209	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584500	171584520	170727990	170728010	78725	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCACCTCTTATAGATGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.654763732	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584537	171584557	170728027	170728047	78726	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCAAGGAAGAAAGGGATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.426068756	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584545	171584565	170728035	170728055	78727	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAAACAGCTCAAGGAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.907508204	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584553	171584573	170728043	170728063	78728	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCCCCACTCAAACAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.230572013	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584554	171584574	170728044	170728064	78729	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCTGTTTGAGTGGGGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207186594	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584557	171584577	170728047	170728067	78730	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGTTTGAGTGGGGATATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.017131415	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584567	171584587	170728057	170728077	78731	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGGGATATGGTGGTGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250634492	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584616	171584636	170728106	170728126	78732	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTCCAGATCCTGGGTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169943799	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584622	171584642	170728112	170728132	78733	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGCCATCAGACCCAGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217842877	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584628	171584648	170728118	170728138	78734	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAGAGAAGCCATCAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.315384587	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584665	171584685	170728155	170728175	78735	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGAATGACTGTTAGACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.42074164	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584666	171584686	170728156	170728176	78736	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGAATGACTGTTAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111776361	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584685	171584705	170728175	170728195	78737	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAGACTTGGGGAATGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.477203354	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584695	171584715	170728185	170728205	78738	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCTGGAGAAATGAGACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.811465586	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584696	171584716	170728186	170728206	78739	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGCTGGAGAAATGAGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.625140581	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584697	171584717	170728187	170728207	78740	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAGCTGGAGAAATGAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.837998655	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584712	171584732	170728202	170728222	78741	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGGAATGTCTTTAAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217504337	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584725	171584745	170728215	170728235	78742	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCCTGTACCACTACCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114090379	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584730	171584750	170728220	170728240	78743	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCCAGGAAGGTAGTGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.314229368	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584736	171584756	170728226	170728246	78744	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAATAGCCAGGAAGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.709607485	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584742	171584762	170728232	170728252	78745	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATTATGATAATAGCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105697846	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584780	171584800	170728270	170728290	78746	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATGTTGAGTGACCATTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.095876457	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584781	171584801	170728271	170728291	78747	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGTTGAGTGACCATTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.114484276	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584845	171584865	170728335	170728355	78748	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGCCACAGCTGAAGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.341632533	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584861	171584881	170728351	170728371	78749	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAGGAGAGTGTCTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136745291	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584878	171584898	170728368	170728388	78750	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGATGGAGAAGAGATGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158083435	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584883	171584903	170728373	170728393	78751	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAGAGATGGTAGTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.287968448	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584884	171584904	170728374	170728394	78752	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAGAGATGGTAGTGGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322899454	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584909	171584929	170728399	170728419	78753	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGTGTTGTGTGGAGGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070130483	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584915	171584935	170728405	170728425	78754	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGTGGAGGACTGATGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012200551	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584918	171584938	170728408	170728428	78755	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGAGGACTGATGGATCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.758308261	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584923	171584943	170728413	170728433	78756	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTGATGGATCTGGAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227670619	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584927	171584947	170728417	170728437	78757	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGGATCTGGAGGTATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.381125257	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584928	171584948	170728418	170728438	78758	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGGATCTGGAGGTATGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.266604838	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584943	171584963	170728433	170728453	78759	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGAAGGGCCATGCCTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.072602754	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584949	171584969	170728439	170728459	78760	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGCCATGCCTCAGAAGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301787144	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584954	171584974	170728444	170728464	78761	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACCTGTTCCTTCTGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.610255617	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584954	171584974	170728444	170728464	78762	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGCCTCAGAAGGAACAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263685532	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171584959	171584979	170728449	170728469	78763	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACCATACCTGTTCCTTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003435422	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585125	171585145	170728615	170728635	78764	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGACGCAACTAAACTGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056553003	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585148	171585168	170728638	170728658	78765	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTCAGGATCTTACATAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.237729384	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585160	171585180	170728650	170728670	78766	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACATAAAAGGCTACAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.205248183	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585176	171585196	170728666	170728686	78767	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAAGGTGTCAGCCAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248494057	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585177	171585197	170728667	170728687	78768	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAAGGTGTCAGCCAAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.482502941	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585178	171585198	170728668	170728688	78769	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGTGTCAGCCAAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.325397183	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585191	171585211	170728681	170728701	78770	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGCTGGGGTCTAATCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452668797	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585200	171585220	170728690	170728710	78771	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTAATCTGAAGGCTCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.392301914	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585206	171585226	170728696	170728716	78772	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTGAAGGCTCGATTGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135260352	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585228	171585248	170728718	170728738	78773	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCCATTTCCAAACTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.160837872	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585234	171585254	170728724	170728744	78774	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAACCACTTGAGTTTGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284321103	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585235	171585255	170728725	170728745	78775	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCCAAACTCAAGTGGTTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.484076715	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585239	171585259	170728729	170728749	78776	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAACTCAAGTGGTTATTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2684689	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585240	171585260	170728730	170728750	78777	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACCAATAACCACTTGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043363055	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585297	171585317	170728787	170728807	78778	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAATAGCCAACAAAGAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.382337153	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585312	171585332	170728802	170728822	78779	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATTGCCTGGAGACTGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.449167803	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585320	171585340	170728810	170728830	78780	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAACCAAAGTCAGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250523753	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585342	171585362	170728832	170728852	78781	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTATATGGGCCTCCCCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279884718	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585354	171585374	170728844	170728864	78782	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAAGCAGCCATGTTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.234588214	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585357	171585377	170728847	170728867	78783	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTGATGAAGCAGCCATGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.320409443	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585358	171585378	170728848	170728868	78784	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTTGATGAAGCAGCCATGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.302217856	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585359	171585379	170728849	170728869	78785	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTTGATGAAGCAGCCATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.212048498	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585373	171585393	170728863	170728883	78786	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAAAGCTTGCAAGCTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.633469186	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585390	171585410	170728880	170728900	78787	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAAGGCAATAAAGTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045351481	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585400	171585420	170728890	170728910	78788	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAGTCAGCTAGGAAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.487258498	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585431	171585451	170728921	170728941	78789	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAATAATCTAATCATAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2464106	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585460	171585480	170728950	170728970	78790	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAGTTAATAGACTGTTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.203841891	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585461	171585481	170728951	170728971	78791	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAACAGTCTATTAACTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.030388398	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585525	171585545	170729015	170729035	78792	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGGAGACAGGAATCATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.691658527	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585527	171585547	170729017	170729037	78793	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCAAATGATTCCTGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.525900635	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585551	171585571	170729041	170729061	78794	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGTAGGTGGCTTCTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.072799006	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585563	171585583	170729053	170729073	78795	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATCACAGGGTGTGGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.399981927	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585566	171585586	170729056	170729076	78796	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGTGCATCACAGGGTGTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261238904	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585570	171585590	170729060	170729080	78797	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGTGTGCATCACAGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.506941354	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585575	171585595	170729065	170729085	78798	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACTGACAGTGTGCATCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.094130407	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585576	171585596	170729066	170729086	78799	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTACTGACAGTGTGCATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.095167242	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585578	171585598	170729068	170729088	78800	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGCACACTGTCAGTAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409297013	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585607	171585627	170729097	170729117	78801	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATATATAGGCCATAAAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.862446864	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585608	171585628	170729098	170729118	78802	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATATAGGCCATAAAGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075090684	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585667	171585687	170729157	170729177	78803	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATTGGCAGTCTCTCATCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133882746	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585685	171585705	170729175	170729195	78804	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAATATGAATGGGTGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073471835	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585690	171585710	170729180	170729200	78805	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAGAAAATATGAATGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.444015263	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585715	171585735	170729205	170729225	78806	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGGGATTACTATTACCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111559295	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585733	171585753	170729223	170729243	78807	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGTACCTCCCAAAAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.180631698	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585734	171585754	170729224	170729244	78808	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATGTACCTCCCAAAAACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077095941	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585735	171585755	170729225	170729245	78809	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCATGTACCTCCCAAAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.34915803	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585762	171585782	170729252	170729272	78810	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGGATATGTCATCTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.295632208	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585781	171585801	170729271	170729291	78811	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACTAGTTGCAAGTGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.306384048	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585782	171585802	170729272	170729292	78812	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTCACTTGCAACTAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11601052	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585786	171585806	170729276	170729296	78813	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCACAACTAGTTGCAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275600005	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585808	171585828	170729298	170729318	78814	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATGACTAAGTTCCCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.002536357	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585808	171585828	170729298	170729318	78815	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTGGTGGGAACTTAGTCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.459354328	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585823	171585843	170729313	170729333	78816	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGCTCACATGCCATTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01528667	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585824	171585844	170729314	170729334	78817	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTAGGCTCACATGCCATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.710889119	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585827	171585847	170729317	170729337	78818	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACTTAGGCTCACATGCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012384096	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585842	171585862	170729332	170729352	78819	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAGTGACATACATCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.517377414	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585911	171585931	170729401	170729421	78820	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATTCCAGCCTCAAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.306285537	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585922	171585942	170729412	170729432	78821	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGGAATGCGGACATAATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220906511	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585923	171585943	170729413	170729433	78822	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGAATGCGGACATAATGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145087824	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585963	171585983	170729453	170729473	78823	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGATAGGACAACACCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.321045545	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585967	171585987	170729457	170729477	78824	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGACAACACCCGAGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.864937318	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585987	171586007	170729477	170729497	78825	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGCAAAGCAACAAAACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.073313873	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585994	171586014	170729484	170729504	78826	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAACAAAACAGAAGGCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.882118056	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171585995	171586015	170729485	170729505	78827	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAACAAAACAGAAGGCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.74295149	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586038	171586058	170729528	170729548	78828	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGAGCAGCCCACCTTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.543836993	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586039	171586059	170729529	170729549	78829	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGAGCAGCCCACCTTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.385891105	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586050	171586070	170729540	170729560	78830	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGCAGCCCAGGAAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.592467793	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586051	171586071	170729541	170729561	78831	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGTAGGCAGCCCAGGAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.573793951	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586054	171586074	170729544	170729564	78832	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGGTAGGCAGCCCAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397767306	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586054	171586074	170729544	170729564	78833	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCCTGGGCTGCCTACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.209734714	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586059	171586079	170729549	170729569	78834	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCAGCTGGTAGGCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.52653226	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586068	171586088	170729558	170729578	78835	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAATAAAAGTCCAGCTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161307771	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586072	171586092	170729562	170729582	78836	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTTCAAATAAAAGTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.212989809	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586094	171586114	170729584	170729604	78837	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGACCATCTTGTTTAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.458319451	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586100	171586120	170729590	170729610	78838	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAACCATGGCTTAAACAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.945635491	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586114	171586134	170729604	170729624	78839	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAACAGGTACCAAGTAACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.124960386	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586161	171586181	170729651	170729671	78840	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGATCACAAAATGCTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009084243	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586174	171586194	170729664	170729684	78841	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTCTAAGGCAGTTATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.480429811	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586183	171586203	170729673	170729693	78842	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGTTATTAACGGTGTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.473650519	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586204	171586224	170729694	170729714	78843	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGTCCCAAGAAGACTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.469786186	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586249	171586269	170729739	170729759	78844	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACCTGAGAAAGCAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225552139	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586269	171586289	170729759	170729779	78845	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTAAATGGTGATATCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.427238701	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586270	171586290	170729760	170729780	78846	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTAAATGGTGATATCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.515749837	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586277	171586297	170729767	170729787	78847	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCACCATTTAAGCCCCTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.559741134	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586283	171586303	170729773	170729793	78848	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGCCTAAGAGGGGCTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.528840116	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586292	171586312	170729782	170729802	78849	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGCAAACACAGCCTAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.639117687	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586293	171586313	170729783	170729803	78850	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAGCAAACACAGCCTAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301740435	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586294	171586314	170729784	170729804	78851	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCAGCAAACACAGCCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108788519	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586322	171586342	170729812	170729832	78852	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATGCGTTCTCACTAGCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050077906	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586323	171586343	170729813	170729833	78853	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGCGTTCTCACTAGCTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.390042803	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586379	171586399	170729869	170729889	78854	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAAGCTGGAAAACAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.73219488	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586387	171586407	170729877	170729897	78855	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCCAGCTTTGCCCATACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175051741	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586392	171586412	170729882	170729902	78856	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACCTGAGTATGGGCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.178397844	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586397	171586417	170729887	170729907	78857	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCCATACTCAGGTACCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.346328041	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586402	171586422	170729892	170729912	78858	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCCTCTTGGTACCTGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104391751	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586415	171586435	170729905	170729925	78859	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCACATGAGTGAAATCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07155194	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586477	171586497	170729967	170729987	78860	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGTCACTGTGTCAGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159325213	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586478	171586498	170729968	170729988	78861	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTCACTGTGTCAGGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006378717	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586521	171586541	170730011	170730031	78862	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACGAGCTTTACACTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.396783727	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586541	171586561	170730031	170730051	78863	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGAAGCTGATATTCCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.289291907	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586545	171586565	170730035	170730055	78864	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCTGATATTCCAGTAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009304119	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586575	171586595	170730065	170730085	78865	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAATAAACAAGATAATTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.315797257	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586622	171586642	170730112	170730132	78866	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGACATGAAGACAAATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.333921842	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586635	171586655	170730125	170730145	78867	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGTCCTCTATAAATTACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.231581749	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586699	171586719	170730189	170730209	78868	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGATAGCTAGCCTCAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151948095	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586713	171586733	170730203	170730223	78869	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTATTGGGGGCCATCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.214535846	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586725	171586745	170730215	170730235	78870	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAAGAGACAAGGACTATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.3529505	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586726	171586746	170730216	170730236	78871	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTAAGAGACAAGGACTATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.635911483	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586727	171586747	170730217	170730237	78872	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTAAGAGACAAGGACTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400121537	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586728	171586748	170730218	170730238	78873	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTTAAGAGACAAGGACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.193062885	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586736	171586756	170730226	170730246	78874	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGAGGCAGTTAAGAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.619830007	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586740	171586760	170730230	170730250	78875	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTTAACTGCCTCAGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.034084431	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586752	171586772	170730242	170730262	78876	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATGCGTCTCCTTCAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.266132588	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586758	171586778	170730248	170730268	78877	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAAGTAATGCGTCTCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.065559622	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586779	171586799	170730269	170730289	78878	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTCACCAATGGAATGTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025122235	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586790	171586810	170730280	170730300	78879	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGGACTAATTCTCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2436371	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586814	171586834	170730304	170730324	78880	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACCTAGAAGCACAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.403002659	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586815	171586835	170730305	170730325	78881	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACCTAGAAGCACAGAGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.329606311	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586835	171586855	170730325	170730345	78882	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGGAAACATAGAGAAGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.187756806	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586879	171586899	170730369	170730389	78883	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAGCATGTTGGCAGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236959964	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586894	171586914	170730384	170730404	78884	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCATCATAAAAATTCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.551206204	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586899	171586919	170730389	170730409	78885	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATAAAAATTCAAGCAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125127182	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586900	171586920	170730390	170730410	78886	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAAAAATTCAAGCAGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.35782182	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171586909	171586929	170730399	170730419	78887	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAGCAGGTCCGGGCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.463867902	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587564	171587584	170731054	170731074	78888	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCAACAGAGGTAGAGGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.445117014	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587645	171587665	170731135	170731155	78889	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACGGCAAGGCACACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.216592563	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587653	171587673	170731143	170731163	78890	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTTGCCGTGTCCCAGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.659200266	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587656	171587676	170731146	170731166	78891	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCAGCATCTGGGACACGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.358518295	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587661	171587681	170731151	170731171	78892	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATATCCAGCATCTGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.793755675	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587667	171587687	170731157	170731177	78893	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGAATCATATCCAGCATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.486790462	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587668	171587688	170731158	170731178	78894	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGAATCATATCCAGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.103146587	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587674	171587694	170731164	170731184	78895	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGATATGATTCCTAACCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.882164417	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587687	171587707	170731177	170731197	78896	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAACTGGAAGCCACGAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.316428003	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587692	171587712	170731182	170731202	78897	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACTCAAACTGGAAGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.17943231	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587766	171587786	170731256	170731276	78898	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAATAGTGTCTAACTTATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.62835458	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587792	171587812	170731282	170731302	78899	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGTGGGGATTAAGTTGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081746047	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587801	171587821	170731291	170731311	78900	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTAAGTTGTACAGGTTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.269634733	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587810	171587830	170731300	170731320	78901	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGGTTAACATGGAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.470482679	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171587811	171587831	170731301	170731321	78902	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGGTTAACATGGAATACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.31946457	SP5	chr2	170715336	170718078	9751				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588333	171588353	170731823	170731843	78903	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAGGAGTAGACCATAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.525198079	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588348	171588368	170731838	170731858	78904	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTTAAACCCTTTCAGTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.237498539	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588349	171588369	170731839	170731859	78905	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTAAACCCTTTCAGTAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.632966202	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588351	171588371	170731841	170731861	78906	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTATTACTGAAAGGGTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142820661	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588358	171588378	170731848	170731868	78907	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTGAGCCCTATTACTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280742381	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588359	171588379	170731849	170731869	78908	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTGAGCCCTATTACTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044050294	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588380	171588400	170731870	170731890	78909	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTACTTCAAAACATAGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397470179	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588430	171588450	170731920	170731940	78910	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATAGGATAAATCCAGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.460383045	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588447	171588467	170731937	170731957	78911	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAATCTCTGGGCTAAATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.711013778	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588453	171588473	170731943	170731963	78912	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCCCAGAGATTCACAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.269687332	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588459	171588479	170731949	170731969	78913	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCCACATCTGTGAATCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2386224	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588466	171588486	170731956	170731976	78914	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGATGTGGAATTCATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.039942076	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588467	171588487	170731957	170731977	78915	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGATGTGGAATTCATGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.533138722	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588545	171588565	170732035	170732055	78916	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATCCTAACCCACCATGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142612148	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588556	171588576	170732046	170732066	78917	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTAATACCATGACATGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150446455	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588655	171588675	170732145	170732165	78918	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGACTAGGGAACTCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.315314024	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588656	171588676	170732146	170732166	78919	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGGACTAGGGAACTCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.061121625	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588657	171588677	170732147	170732167	78920	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACAGGACTAGGGAACTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.084509225	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588667	171588687	170732157	170732177	78921	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACATGGCAGAAACAGGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124775094	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588668	171588688	170732158	170732178	78922	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACATGGCAGAAACAGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090721829	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588705	171588725	170732195	170732215	78923	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCTGTCTGAAACCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.833229583	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588706	171588726	170732196	170732216	78924	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTGTCTGAAACCTGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01544544	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588744	171588764	170732234	170732254	78925	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAGAGTAACAACATGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.321430341	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588745	171588765	170732235	170732255	78926	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTAAGAGTAACAACATGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.162891239	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588749	171588769	170732239	170732259	78927	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAAGGTAAGAGTAACAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.379791303	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588888	171588908	170732378	170732398	78928	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGCACTCTCCAGAAAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263676835	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588911	171588931	170732401	170732421	78929	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCAGGATTCAACTAAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.146577505	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588952	171588972	170732442	170732462	78930	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAAGAACTGTGATTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.546293661	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588979	171588999	170732469	170732489	78931	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTTGATCAAGGTCAAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.097986053	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588984	171589004	170732474	170732494	78932	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACATAGTTGATCAAGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.424235511	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171588990	171589010	170732480	170732500	78933	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGTAAACATAGTTGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.546431676	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589030	171589050	170732520	170732540	78934	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTTAACTAAACACACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.242182665	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589046	171589066	170732536	170732556	78935	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATCATTCATCCTTCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.358554381	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589052	171589072	170732542	170732562	78936	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCATCCTTCTGGACTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.025970801	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589059	171589079	170732549	170732569	78937	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCACCACGCCCAGTCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.390241141	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589197	171589217	170732687	170732707	78938	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAACAAACAAGTTTAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.329258873	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589201	171589221	170732691	170732711	78939	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAACAAGTTTAGCAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.113723391	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589487	171589507	170732977	170732997	78940	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAAGAGCTGGAAATATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.827069895	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589498	171589518	170732988	170733008	78941	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCTGTCCCACTGAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.739494642	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589531	171589551	170733021	170733041	78942	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAACTCAAGTATATCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084553848	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589562	171589582	170733052	170733072	78943	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTAAATATCTTCCCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.289005336	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589563	171589583	170733053	170733073	78944	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGTCTGGGAAGATATTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115590849	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589564	171589584	170733054	170733074	78945	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGGTCTGGGAAGATATTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.094987711	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589565	171589585	170733055	170733075	78946	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGGTCTGGGAAGATATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052309521	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589638	171589658	170733128	170733148	78947	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACAAGGCCATATTCTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.25865227	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589654	171589674	170733144	170733164	78948	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGGGGAAATTCTAAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.742691227	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589670	171589690	170733160	170733180	78949	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTAGCATGACTATAAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.732139358	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589671	171589691	170733161	170733181	78950	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTAGCATGACTATAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.472592174	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589672	171589692	170733162	170733182	78951	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTAGCATGACTATAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016925756	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589696	171589716	170733186	170733206	78952	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATATGTATCTTCTCAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.154256155	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589743	171589763	170733233	170733253	78953	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCATTGGGAACACATTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073742543	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589757	171589777	170733247	170733267	78954	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCATTAAGTTCTAGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072021773	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589758	171589778	170733248	170733268	78955	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCATTAAGTTCTAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.454863116	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589847	171589867	170733337	170733357	78956	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACAAATAAAATCTTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.556666598	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589888	171589908	170733378	170733398	78957	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATCCCAAAGCATCAAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046884419	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589889	171589909	170733379	170733399	78958	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATCCCAAAGCATCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.93541267	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589894	171589914	170733384	170733404	78959	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGCTTTGGGATTTCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15703175	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589918	171589938	170733408	170733428	78960	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAAAGAGTATGTATGATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.02504342	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589953	171589973	170733443	170733463	78961	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTCTCTGAGATCATATAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273125758	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589998	171590018	170733488	170733508	78962	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGTAATTCCTTAGGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.408225778	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171589998	171590018	170733488	170733508	78963	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTCCTAAGGAATTACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.067363685	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590010	171590030	170733500	170733520	78964	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATCAGTCACCAAGGTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176130564	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590018	171590038	170733508	170733528	78965	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACACATCTCATCAGTCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151209839	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590019	171590039	170733509	170733529	78966	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGACTGATGAGATGTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.189251178	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590036	171590056	170733526	170733546	78967	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGGAGTCTCCTTGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.232743032	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590037	171590057	170733527	170733547	78968	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGGAGTCTCCTTGTAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012837322	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590038	171590058	170733528	170733548	78969	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGAGTCTCCTTGTAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.288970538	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590050	171590070	170733540	170733560	78970	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAGAACACCCCATCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.123378359	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590095	171590115	170733585	170733605	78971	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTGATAACTACCAACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.526691683	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590097	171590117	170733587	170733607	78972	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCTGTTGGTAGTTATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.324566799	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590110	171590130	170733600	170733620	78973	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGGGATCATCCAGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.372771275	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590127	171590147	170733617	170733637	78974	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGACTCATAACAGAAGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099065905	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590152	171590172	170733642	170733662	78975	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGTATGCTTGAAATTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199006935	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590153	171590173	170733643	170733663	78976	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAGTATGCTTGAAATTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.152689848	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590154	171590174	170733644	170733664	78977	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGAGTATGCTTGAAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.135978304	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590162	171590182	170733652	170733672	78978	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCATACTCTGTGCCCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.409938521	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590178	171590198	170733668	170733688	78979	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATCAATCAATGGCCTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076727267	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590179	171590199	170733669	170733689	78980	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATCAATCAATGGCCTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073539539	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590180	171590200	170733670	170733690	78981	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTATCAATCAATGGCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.335129007	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590188	171590208	170733678	170733698	78982	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATACTGTGTATCAATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.038633447	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590207	171590227	170733697	170733717	78983	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAATACCCAGTGTTGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122119154	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590208	171590228	170733698	170733718	78984	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATACCCAGTGTTGTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.308042248	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590246	171590266	170733736	170733756	78985	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGAGTGGAAGAAGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.088467283	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590316	171590336	170733806	170733826	78986	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGCCAGCCTAGTAAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136325521	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590317	171590337	170733807	170733827	78987	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCCAGCCTAGTAAAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.634317882	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590323	171590343	170733813	170733833	78988	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATCCCTCACTTTACTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.501309018	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590327	171590347	170733817	170733837	78989	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTCATCCCTCACTTTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084396988	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590343	171590363	170733833	170733853	78990	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCTTTAGATAGACCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.390912895	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590344	171590364	170733834	170733854	78991	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTTTAGATAGACCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.059499762	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590360	171590380	170733850	170733870	78992	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAAACTGAAGCTCCCTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.474643718	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590360	171590380	170733850	170733870	78993	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGGGAGCTTCAGTTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148929592	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590361	171590381	170733851	170733871	78994	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTAAACTGAAGCTCCCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.47930377	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590362	171590382	170733852	170733872	78995	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTAAACTGAAGCTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.651601798	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590376	171590396	170733866	170733886	78996	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAAAGGCTTACCCAAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.631120612	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590377	171590397	170733867	170733887	78997	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAAGGCTTACCCAAAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.330676641	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590390	171590410	170733880	170733900	78998	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGAGAAAGCCCTGACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124142652	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590391	171590411	170733881	170733901	78999	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGAGAAAGCCCTGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.162780697	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590399	171590419	170733889	170733909	79000	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTCTCCCTCCAGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.180090581	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590410	171590430	170733900	170733920	79001	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAAAGTTCCAGCTCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.224710046	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590413	171590433	170733903	170733923	79002	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCTAAAGTTCCAGCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.31509155	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590425	171590445	170733915	170733935	79003	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTAGAGAAGAACCTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.873544085	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590440	171590460	170733930	170733950	79004	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCTGTTCTGCCAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286310303	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590445	171590465	170733935	170733955	79005	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTACAGCAGCTGTTCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.312440982	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590446	171590466	170733936	170733956	79006	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTACAGCAGCTGTTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.185260422	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590466	171590486	170733956	170733976	79007	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCAGTTCATAGGAGTTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.321570625	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590467	171590487	170733957	170733977	79008	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGTTCATAGGAGTTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200277857	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590470	171590490	170733960	170733980	79009	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCTGCAAACTCCTATGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.155098694	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590516	171590536	170734006	170734026	79010	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGAAAGGACTTCAGACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.399349437	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590543	171590563	170734033	170734053	79011	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGCTAATTGCATGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.080453435	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590546	171590566	170734036	170734056	79012	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGAAGTCATGCAATTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.178807631	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590586	171590606	170734076	170734096	79013	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTTATCTGAAAACTGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.338022427	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590608	171590628	170734098	170734118	79014	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGACTGGATGATCTCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045417471	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590664	171590684	170734154	170734174	79015	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACGCTTGTGTATCTAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.449671169	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590672	171590692	170734162	170734182	79016	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTATCTAACCAGGTGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.395417093	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590685	171590705	170734175	170734195	79017	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATAGGTAAGCCAGAACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.342468029	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590702	171590722	170734192	170734212	79018	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGTGGTTCTACTTAGCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.480618949	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590712	171590732	170734202	170734222	79019	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAACCACCCCAATACTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.784481826	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590719	171590739	170734209	170734229	79020	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGCCATTAAGTATTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207160322	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590751	171590771	170734241	170734261	79021	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTACATGAGCATAGTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227177834	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590755	171590775	170734245	170734265	79022	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTATGCTCATGTACTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.979459795	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590760	171590780	170734250	170734270	79023	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCATGTACTCTGCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.340594167	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590772	171590792	170734262	170734282	79024	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCAGGACAGGAATTCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.374503676	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590773	171590793	170734263	170734283	79025	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGACAGGAATTCACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.243946083	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590787	171590807	170734277	170734297	79026	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAAAGGGCACAGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.453488461	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590788	171590808	170734278	170734298	79027	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAAAGGGCACAGTGAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.41675582	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590808	171590828	170734298	170734318	79028	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGCTGTGTCCTACAGTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.357909831	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590820	171590840	170734310	170734330	79029	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGAGGCTCCAGACACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167289157	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590821	171590841	170734311	170734331	79030	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGTCTGGAGCCTCCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.35038919	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590835	171590855	170734325	170734345	79031	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTTTAGGAATGACTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005458708	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590836	171590856	170734326	170734346	79032	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGGAGTCATTCCTAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.210185376	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590836	171590856	170734326	170734346	79033	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTTTAGGAATGACTCCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.339459448	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590837	171590857	170734327	170734347	79034	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTAGGAATGACTCCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.534867913	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590838	171590858	170734328	170734348	79035	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTAGGAATGACTCCATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.410727209	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590839	171590859	170734329	170734349	79036	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCAATGGAGTCATTCCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273081505	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590854	171590874	170734344	170734364	79037	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCATTCAAGTCACCCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.580714073	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590854	171590874	170734344	170734364	79038	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGGGGTGACTTGAATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.190791506	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590855	171590875	170734345	170734365	79039	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGGGTGACTTGAATGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328159405	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590871	171590891	170734361	170734381	79040	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGGGAGCTAGAATCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.3487242	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590875	171590895	170734365	170734385	79041	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCAGATGATTCTAGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.553957974	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590895	171590915	170734385	170734405	79042	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGCTTTGCTGACATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23075119	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590916	171590936	170734406	170734426	79043	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCATGCTAGCTCAGGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044032027	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590923	171590943	170734413	170734433	79044	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTCAATTCATGCTAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125849308	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590962	171590982	170734452	170734472	79045	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAACCAGAGCACCTATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07473144	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590969	171590989	170734459	170734479	79046	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGCCACAAATAGGTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59469428	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590975	171590995	170734465	170734485	79047	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTATTTGTGGCCTCCACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.162735897	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590977	171590997	170734467	170734487	79048	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGTGTGGAGGCCACAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070121102	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590991	171591011	170734481	170734501	79049	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGAAACACAAGCCATGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28771111	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171590996	171591016	170734486	170734506	79050	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTTGTGTTTCACACAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.88654254	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591032	171591052	170734522	170734542	79051	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTAAAAAGACATTCCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060175411	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591073	171591093	170734563	170734583	79052	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGTTATAAGCAAATCACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.016814302	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591104	171591124	170734594	170734614	79053	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCAAGGGAATCTAGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.068816137	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591126	171591146	170734616	170734636	79054	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAGACTCCAGAACTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09806985	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591127	171591147	170734617	170734637	79055	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAGACTCCAGAACTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.161600447	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591128	171591148	170734618	170734638	79056	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGACTCCAGAACTTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.245399884	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591129	171591149	170734619	170734639	79057	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGACTCCAGAACTTGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.129753144	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591134	171591154	170734624	170734644	79058	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCAGAACTTGAAGGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.803485408	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591138	171591158	170734628	170734648	79059	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTCCCCCTTCAAGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264153529	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591153	171591173	170734643	170734663	79060	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCCAATTCACATTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136608088	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591160	171591180	170734650	170734670	79061	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGATCCTTTGCAATGTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084376553	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591291	171591311	170734781	170734801	79062	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAACCCTCCCTTTCCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.080618591	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591325	171591345	170734815	170734835	79063	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCTCCTCCCTTGAAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012242628	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591329	171591349	170734819	170734839	79064	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGAATTTCAAGGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.148221228	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591330	171591350	170734820	170734840	79065	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCCTGAATTTCAAGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087681029	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591333	171591353	170734823	170734843	79066	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGTGCCTGAATTTCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.399048975	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591382	171591402	170734872	170734892	79067	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAAGACTGACAAAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.030767453	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591387	171591407	170734877	170734897	79068	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGACAAAAGAGCTGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.117668695	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591390	171591410	170734880	170734900	79069	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGACAAAAGAGCTGGCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.384080487	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591738	171591758	170735228	170735248	79070	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAATAAGATACCAAATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.886017701	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591759	171591779	170735249	170735269	79071	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGCTATACTACAGTCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068360079	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591862	171591882	170735352	170735372	79072	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAACTATCTATCTCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.120455337	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591905	171591925	170735395	170735415	79073	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAATCCCCTTCTCTTTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.533846425	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591942	171591962	170735432	170735452	79074	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAGAGATTAAACTGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.523659669	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591943	171591963	170735433	170735453	79075	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGACTCAGTTTAATCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.100523459	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591953	171591973	170735443	170735463	79076	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACTGAGTCCGGTATCCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400620423	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591954	171591974	170735444	170735464	79077	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGAGTCCGGTATCCTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.374430287	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591964	171591984	170735454	170735474	79078	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATCAGACCCTAAAGGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050831457	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171591971	171591991	170735461	170735481	79079	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCTCTTATCAGACCCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02030413	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592412	171592432	170735902	170735922	79080	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAAAGACTTGGAGTTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39375871	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592413	171592433	170735903	170735923	79081	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTAAAGACTTGGAGTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047225668	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592417	171592437	170735907	170735927	79082	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTATCTAAAGACTTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.148307002	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592463	171592483	170735953	170735973	79083	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGATTCAACAACTTTCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.4454516	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592642	171592662	170736132	170736152	79084	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTCTTGAGACAGCGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.182007414	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592643	171592663	170736133	170736153	79085	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTCTTGAGACAGCGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138005362	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592647	171592667	170736137	170736157	79086	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCGAGACGCTGTCTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.759700313	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592649	171592669	170736139	170736159	79087	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGACAGCGTCTCGGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.7598766	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592700	171592720	170736190	170736210	79088	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCTGTAAAATAGTAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.928022511	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592729	171592749	170736219	170736239	79089	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCATCAACACCATCATCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070873996	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592775	171592795	170736265	170736285	79090	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCGGCTATTGCTGGCATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.712679456	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592776	171592796	170736266	170736286	79091	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCGGCTATTGCTGGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.105233459	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592783	171592803	170736273	170736293	79092	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGATGTGAGCGGCTATTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.237071222	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592827	171592847	170736317	170736337	79093	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTATTTAGAGTCACATCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.408128982	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592830	171592850	170736320	170736340	79094	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACAGTATTTAGAGTCACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.669326786	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592854	171592874	170736344	170736364	79095	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTCAGAAAGATTTCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.323663949	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592885	171592905	170736375	170736395	79096	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACACTTTCAGACAGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.268816676	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592895	171592915	170736385	170736405	79097	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGACAGAAGTAGGCCTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.485853875	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592922	171592942	170736412	170736432	79098	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAAACACCACTTGTGTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.353947101	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592932	171592952	170736422	170736442	79099	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAGGGCCAAAGACACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.622706138	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592948	171592968	170736438	170736458	79100	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCGAAATCTGGAAGACCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183476057	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592949	171592969	170736439	170736459	79101	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCGAAATCTGGAAGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186398868	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592961	171592981	170736451	170736471	79102	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTTCGAGAAACCATACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.148831887	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592962	171592982	170736452	170736472	79103	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTCGAGAAACCATACTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.605995747	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592963	171592983	170736453	170736473	79104	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCGAGAAACCATACTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.193674838	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592975	171592995	170736465	170736485	79105	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGGGTACAGCCCCTTTAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.327707701	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592992	171593012	170736482	170736502	79106	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCGAGAAACCTCATCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.118884914	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592994	171593014	170736484	170736504	79107	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCGCTGATGAGGTTTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.595721489	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171592995	171593015	170736485	170736505	79108	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGCGCTGATGAGGTTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214367122	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593003	171593023	170736493	170736513	79109	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCAGGTGCCAGCGCTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.117522771	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593007	171593027	170736497	170736517	79110	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCGCTGGCACCTGATTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.796639427	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593018	171593038	170736508	170736528	79111	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGATTTGATGGCAAAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.584463827	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593042	171593062	170736532	170736552	79112	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTTGAACTGATGCAGTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055046428	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593065	171593085	170736555	170736575	79113	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAAGACTCTGTAGACCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.620593276	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593070	171593090	170736560	170736580	79114	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCTGTAGACCTTCAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006567092	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593071	171593091	170736561	170736581	79115	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTGTAGACCTTCAGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.511931166	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593163	171593183	170736653	170736673	79116	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGCAATGGCTGAATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009089634	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593163	171593183	170736653	170736673	79117	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAATTCAGCCATTGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198454143	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593164	171593184	170736654	170736674	79118	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGTGCAATGGCTGAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.069949735	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593165	171593185	170736655	170736675	79119	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCAGTGCAATGGCTGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082270611	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593166	171593186	170736656	170736676	79120	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTCAGTGCAATGGCTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.202959607	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593175	171593195	170736665	170736685	79121	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTGAAGGTCCTCAGTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138991366	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593190	171593210	170736680	170736700	79122	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGTTAGCAAAGCATTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39695876	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593229	171593249	170736719	170736739	79123	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTTTAGAGGAAGTATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.649531948	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593230	171593250	170736720	170736740	79124	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACACTTTAGAGGAAGTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.236348332	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593232	171593252	170736722	170736742	79125	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATACTTCCTCTAAAGTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.519140949	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593233	171593253	170736723	170736743	79126	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCACACTTTAGAGGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.115802953	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593271	171593291	170736761	170736781	79127	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAAATATGGCTGGAGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012895348	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593280	171593300	170736770	170736790	79128	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACTTATGATGAAATATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152011247	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593310	171593330	170736800	170736820	79129	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACACTTTAAATTGTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.064691346	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593331	171593351	170736821	170736841	79130	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTGGCCAAGGATATTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060426375	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593335	171593355	170736825	170736845	79131	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATATCCTTGGCCAAACCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.22580883	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593342	171593362	170736832	170736852	79132	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAACCAGTGGGTTTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.011288144	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593344	171593364	170736834	170736854	79133	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAAACCCACTGGTTCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.215025477	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593348	171593368	170736838	170736858	79134	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTAATGAACCAGTGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.013710874	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593353	171593373	170736843	170736863	79135	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATATACCTAATGAACCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.782940453	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593354	171593374	170736844	170736864	79136	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATATACCTAATGAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.276029078	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593416	171593436	170736906	170736926	79137	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTCGTTAAATGTAGCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099501858	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593449	171593469	170736939	170736959	79138	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAAGTTATGACTGGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.532208769	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593452	171593472	170736942	170736962	79139	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGAGGAAGTTATGACTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202749317	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593453	171593473	170736943	170736963	79140	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGGAGGAAGTTATGACTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.333632484	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593456	171593476	170736946	170736966	79141	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGGGGAGGAAGTTATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087838958	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593470	171593490	170736960	170736980	79142	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCATCTTTCCAGCCTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021151229	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593472	171593492	170736962	170736982	79143	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGAAGGCTGGAAAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.589468697	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593473	171593493	170736963	170736983	79144	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGTGAAGGCTGGAAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228071469	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593474	171593494	170736964	170736984	79145	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCAGTGAAGGCTGGAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051422614	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593482	171593502	170736972	170736992	79146	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAGACTACCAGTGAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.515935997	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593486	171593506	170736976	170736996	79147	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTGAGAAGACTACCAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.082646105	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593515	171593535	170737005	170737025	79148	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAGTTTGTTGGTGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.090655044	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593517	171593537	170737007	170737027	79149	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTCACCAACAAACTTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026816396	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593525	171593545	170737015	170737035	79150	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGGCCTTGAGAAGTTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133334669	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593558	171593578	170737048	170737068	79151	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAATATACATACAGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145206389	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593643	171593663	170737133	170737153	79152	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTTTCTCTAAATCATGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060212076	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593648	171593668	170737138	170737158	79153	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGGCTGGTTTCTCTAAATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.015735206	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593664	171593684	170737154	170737174	79154	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAGGCTTGCTTCTTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224195362	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593681	171593701	170737171	170737191	79155	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAGCAGACTGATTTCTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.120342219	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593726	171593746	170737216	170737236	79156	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAATAGCCTCTGTAACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322892212	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593736	171593756	170737226	170737246	79157	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTGGGGCCAGTTGTTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.43863349	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593811	171593831	170737301	170737321	79158	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGCTGTAAGTTGGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121556515	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593812	171593832	170737302	170737322	79159	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGCTGTAAGTTGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.292365916	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593813	171593833	170737303	170737323	79160	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTCCAACTTACAGCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1831871	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593813	171593833	170737303	170737323	79161	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTTGGCTGTAAGTTGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.31022353	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593814	171593834	170737304	170737324	79162	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCAACTTACAGCCAACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.142180251	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593834	171593854	170737324	170737344	79163	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGCACATTTGGCTTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000952865	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593844	171593864	170737334	170737354	79164	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGGTTAGACTGCACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.487177052	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593848	171593868	170737338	170737358	79165	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCAGTCTAACCAGTCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108092578	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593861	171593881	170737351	170737371	79166	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTGGGGCATCCTCTTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223591529	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593877	171593897	170737367	170737387	79167	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTTAGGCTAACTAGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397098938	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593879	171593899	170737369	170737389	79168	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAGTTAGGCTAACTAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.29919961	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593893	171593913	170737383	170737403	79169	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCATTGGGAAGCTTTAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245275734	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593906	171593926	170737396	170737416	79170	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATGCCAGCAGCCTCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.192652334	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593907	171593927	170737397	170737417	79171	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATTGGAGGCTGCTGGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.446607097	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593907	171593927	170737397	170737417	79172	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGCCAGCAGCCTCCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06796135	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593908	171593928	170737398	170737418	79173	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTATTGGAGGCTGCTGGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.19746379	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593914	171593934	170737404	170737424	79174	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGCCCTATTGGAGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.287664511	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593924	171593944	170737414	170737434	79175	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGCTTTGGGTATGCCCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033641224	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593971	171593991	170737461	170737481	79176	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCAAAAGCAGGCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.484628951	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593972	171593992	170737462	170737482	79177	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTCAAAAGCAGGCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.529672573	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593977	171593997	170737467	170737487	79178	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGACACTCAAAAGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.540240234	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593978	171593998	170737468	170737488	79179	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAAGACACTCAAAAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.381460323	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593981	171594001	170737471	170737491	79180	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGGAAGACACTCAAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075691382	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593991	171594011	170737481	170737501	79181	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTTCCCAAATGCAAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08222539	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171593998	171594018	170737488	170737508	79182	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAATGCAAGTAATGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.812907883	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594000	171594020	170737490	170737510	79183	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCTGCCATTACTTGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.092042643	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594037	171594057	170737527	170737547	79184	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCTCTAAATAAATAGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.162750616	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594056	171594076	170737546	170737566	79185	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACCAAATGAGAATAACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133666391	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594085	171594105	170737575	170737595	79186	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGAAGCTTGTGGAAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.218205747	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594094	171594114	170737584	170737604	79187	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTCAGCAGAAAGAAGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.419438519	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594156	171594176	170737646	170737666	79188	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGGGAGAATCCCACTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.003101973	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594174	171594194	170737664	170737684	79189	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGGTACCAAATTCTGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236099843	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594184	171594204	170737674	170737694	79190	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGATAACCAGAACAGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027265953	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594286	171594306	170737776	170737796	79191	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTCAGATACAGTACAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.454294842	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594290	171594310	170737780	170737800	79192	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGATACAGTACAACAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.245441904	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594326	171594346	170737816	170737836	79193	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGACACCCTAGATATTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.499014421	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594327	171594347	170737817	170737837	79194	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAATATCTAGGGTGTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.411549174	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594327	171594347	170737817	170737837	79195	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGACACCCTAGATATTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.070021184	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594328	171594348	170737818	170737838	79196	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATATCTAGGGTGTCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.08569264	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594328	171594348	170737818	170737838	79197	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACTGACACCCTAGATATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.259804933	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594336	171594356	170737826	170737846	79198	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGTGTCAGTTGGGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.757392166	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594346	171594366	170737836	170737856	79199	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGGGAAAACTGGAATGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.537479187	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594347	171594367	170737837	170737857	79200	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGAAAACTGGAATGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.615115039	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594348	171594368	170737838	170737858	79201	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGAAAACTGGAATGACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.650693093	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594352	171594372	170737842	170737862	79202	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAACTGGAATGACTAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126114072	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594362	171594382	170737852	170737872	79203	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTAGGGGCAGGAATCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057559685	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594365	171594385	170737855	170737875	79204	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGGGGCAGGAATCACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.194053229	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594383	171594403	170737873	170737893	79205	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGTGAGTGGGGCAGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040874619	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594393	171594413	170737883	170737903	79206	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTCACATGTCTGTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261649224	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594395	171594415	170737885	170737905	79207	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGCAACAGACATGTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.210231633	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594396	171594416	170737886	170737906	79208	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGGCAACAGACATGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134581808	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594400	171594420	170737890	170737910	79209	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGTCTGTTGCCTGGGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.496528685	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594403	171594423	170737893	170737913	79210	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTGTTGCCTGGGCTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.798865263	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594414	171594434	170737904	170737924	79211	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTTCAAGCCACCCTAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.36941525	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594415	171594435	170737905	170737925	79212	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTAGGGTGGCTTGAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.036434461	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594416	171594436	170737906	170737926	79213	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGGGTGGCTTGAAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200427659	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594431	171594451	170737921	170737941	79214	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGACTGGGCTCAGCTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.523073047	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594454	171594474	170737944	170737964	79215	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAACCAGAAAACCTGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320218483	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594467	171594487	170737957	170737977	79216	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCCACGTGGCTTTCCCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23241665	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594468	171594488	170737958	170737978	79217	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACATGGGAAAGCCACGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.062315018	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594472	171594492	170737962	170737982	79218	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCCACATGGGAAAGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.543275443	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594472	171594492	170737962	170737982	79219	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGTGGCTTTCCCATGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.031371329	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594484	171594504	170737974	170737994	79220	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGAAGAGCCAAGCCACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.120558146	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594485	171594505	170737975	170737995	79221	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGAAGAGCCAAGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.353646869	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594487	171594507	170737977	170737997	79222	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCTTGGCTCTTCACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01065136	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594490	171594510	170737980	170738000	79223	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTGGCTCTTCACAGCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.122202291	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594521	171594541	170738011	170738031	79224	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCAGGACACTCCCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.402343553	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594522	171594542	170738012	170738032	79225	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTCAGGACACTCCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.255803087	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594530	171594550	170738020	170738040	79226	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCCTGAGAGGCACAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021789965	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594537	171594557	170738027	170738047	79227	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACGGCCTGGCTGTGCCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108307008	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594551	171594571	170738041	170738061	79228	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTTAGAACATTCACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.350458107	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594553	171594573	170738043	170738063	79229	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCGTGAATGTTCTAAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.457192786	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594556	171594576	170738046	170738066	79230	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAATGTTCTAAGAGAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.488382096	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594593	171594613	170738083	170738103	79231	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTCCAAAGCTAATCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.252072926	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594640	171594660	170738130	170738150	79232	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGACTAATATATATTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173170749	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594643	171594663	170738133	170738153	79233	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTAATATATATTCAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.925202961	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594644	171594664	170738134	170738154	79234	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAATATATATTCAAAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.44965817	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594714	171594734	170738204	170738224	79235	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGAGTTCTCCATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216573447	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594987	171595007	170738477	170738497	79236	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAAGAGACAGAATCTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.23831926	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594988	171595008	170738478	170738498	79237	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCAAGAGACAGAATCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.741551779	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171594992	171595012	170738482	170738502	79238	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACATCAAGAGACAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.480257554	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595020	171595040	170738510	170738530	79239	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTCCCTCTGCAGAACACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236351644	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595025	171595045	170738515	170738535	79240	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTCTGCAGAACACGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.044864509	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595026	171595046	170738516	170738536	79241	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTGCAGAACACGTGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.179847607	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595027	171595047	170738517	170738537	79242	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATTCCACGTGTTCTGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072397195	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595028	171595048	170738518	170738538	79243	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCATTCCACGTGTTCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.49139714	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595049	171595069	170738539	170738559	79244	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGACTGTTGCAGTCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.979172458	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595072	171595092	170738562	170738582	79245	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAACTATGATTTGCCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273404663	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595093	171595113	170738583	170738603	79246	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTTCAGGAAGAGGGTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.077436192	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595098	171595118	170738588	170738608	79247	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGGATTTCAGGAAGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.355573038	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595101	171595121	170738591	170738611	79248	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAGATGGATTTCAGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.190053762	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595102	171595122	170738592	170738612	79249	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATAGATGGATTTCAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061899777	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595108	171595128	170738598	170738618	79250	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAATGAATAGATGGATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.453126065	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595267	171595287	170738757	170738777	79251	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGCAATATAGTGTAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.540624263	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595268	171595288	170738758	170738778	79252	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGCAATATAGTGTAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026799491	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595268	171595288	170738758	170738778	79253	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTCTACACTATATTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.074102483	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595534	171595554	170739024	170739044	79254	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTGTAGTTAGAAGACGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301452124	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595537	171595557	170739027	170739047	79255	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGTTAGAAGACGTATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.460756509	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595538	171595558	170739028	170739048	79256	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGTTAGAAGACGTATTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.190910198	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595543	171595563	170739033	170739053	79257	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAGACGTATTGGTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.064831826	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595557	171595577	170739047	170739067	79258	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGCATGGAAGCAAAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103496869	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595564	171595584	170739054	170739074	79259	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAAGCAAAACAAAGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.725368008	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595575	171595595	170739065	170739085	79260	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGGAAGTTGGTTGCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127249505	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595592	171595612	170739082	170739102	79261	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCAGGTGATAATTTCATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.393334164	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595634	171595654	170739124	170739144	79262	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAATGCTTAAAAAATACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.076155425	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595651	171595671	170739141	170739161	79263	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAACAATAGGCTCACGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084097399	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595668	171595688	170739158	170739178	79264	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGGTCAGCACAGATGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104416878	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595669	171595689	170739159	170739179	79265	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGGTCAGCACAGATGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.18535501	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595670	171595690	170739160	170739180	79266	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGTCAGCACAGATGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.18696132	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595714	171595734	170739204	170739224	79267	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTAAGCTTCATGAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.939018215	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595718	171595738	170739208	170739228	79268	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCATGAAGCTTAAGTCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264885962	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595723	171595743	170739213	170739233	79269	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGCTTAAGTCCAGTTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062155425	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595736	171595756	170739226	170739246	79270	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGTGTTTGCCTTGCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.061101223	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595797	171595817	170739287	170739307	79271	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCACAAATGTTATGCAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.509615063	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595803	171595823	170739293	170739313	79272	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGTTATGCAGTCATGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121075753	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595818	171595838	170739308	170739328	79273	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTCCAGGAATGTGCTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.010929177	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595824	171595844	170739314	170739334	79274	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCCTATGCAGCACATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.25813901	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595825	171595845	170739315	170739335	79275	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGTGCTGCATAGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.123091173	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595857	171595877	170739347	170739367	79276	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAAGTCTTCTCTAACTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.198576937	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595919	171595939	170739409	170739429	79277	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAAAAAGTAATTAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.172001336	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171595950	171595970	170739440	170739460	79278	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTATGTTACAGAAACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.995254388	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596032	171596052	170739522	170739542	79279	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATGGAAAGCCAATTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.367227798	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596138	171596158	170739628	170739648	79280	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGTACGCATTACACAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.219826041	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596139	171596159	170739629	170739649	79281	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTACGCATTACACAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.477946687	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596151	171596171	170739641	170739661	79282	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGAAAGGGCAAACATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.566873692	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596158	171596178	170739648	170739668	79283	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGCAAACATGAAGGTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.205918957	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596176	171596196	170739666	170739686	79284	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAGGTGTAAACCTGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.580322063	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596186	171596206	170739676	170739696	79285	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTGAAGCTTGGTAAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221190649	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596190	171596210	170739680	170739700	79286	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCAGTATTTACCAAGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159464078	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596192	171596212	170739682	170739702	79287	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCTTGGTAAATACTGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26866905	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596200	171596220	170739690	170739710	79288	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATACTGGACTAGGCGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.095216953	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596203	171596223	170739693	170739713	79289	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACTGGACTAGGCGTGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.354564496	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596207	171596227	170739697	170739717	79290	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGACTAGGCGTGTTGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.379223434	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596208	171596228	170739698	170739718	79291	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTAGGCGTGTTGGAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428637229	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596228	171596248	170739718	170739738	79292	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGTTGAGGAGAGGAGTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196952011	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596236	171596256	170739726	170739746	79293	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGGAGTCATGGGCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.940214994	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596237	171596257	170739727	170739747	79294	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGGAGTCATGGGCATAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081513695	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596246	171596266	170739736	170739756	79295	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGGGCATAAAGGGAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.653308968	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596264	171596284	170739754	170739774	79296	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGGTGCAAAAGCCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.307053129	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596278	171596298	170739768	170739788	79297	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAAGTGGAAGAAAGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.616830444	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596279	171596299	170739769	170739789	79298	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAAGTGGAAGAAAGACTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.476571311	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596280	171596300	170739770	170739790	79299	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTGGAAGAAAGACTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.333050504	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596298	171596318	170739788	170739808	79300	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGGTCCAACAAGCAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07135523	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596309	171596329	170739799	170739819	79301	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGCAGAAAAGGAGCCAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301810614	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596351	171596371	170739841	170739861	79302	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTCACTCACTGTGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.015007984	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596356	171596376	170739846	170739866	79303	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTCACTGTGAGCCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.283946857	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596364	171596384	170739854	170739874	79304	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGCCAGGAGAGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.27155933	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596372	171596392	170739862	170739882	79305	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGTCCTGCTGGCCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.282437477	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596379	171596399	170739869	170739889	79306	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGCAGGACCTTGATATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.232395174	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596380	171596400	170739870	170739890	79307	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCAGGACCTTGATATTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.296031604	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596382	171596402	170739872	170739892	79308	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGAATATCAAGGTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.118490674	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596391	171596411	170739881	170739901	79309	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTAAAGTCCCTGAATATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.139033859	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596462	171596482	170739952	170739972	79310	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCACAAGTACAATATTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.342969338	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596463	171596483	170739953	170739973	79311	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCACAAGTACAATATTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39420709	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596727	171596747	170740217	170740237	79312	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGTTGACCAGGCCCATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096535264	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596736	171596756	170740226	170740246	79313	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGCCCATTCTGGAACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093233482	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596738	171596758	170740228	170740248	79314	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGAGTTCCAGAATGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.332783315	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596826	171596846	170740316	170740336	79315	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAAAATTTACTATTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145821369	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596941	171596961	170740431	170740451	79316	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCAATTATCCTAAAAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051300681	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596942	171596962	170740432	170740452	79317	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAATTATCCTAAAAGCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.28561835	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596961	171596981	170740451	170740471	79318	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGACACCATTGAAGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.400830836	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596962	171596982	170740452	170740472	79319	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGACACCATTGAAGAATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.419526081	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171596969	171596989	170740459	170740479	79320	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATTGAAGAATTTGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.483177838	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597046	171597066	170740536	170740556	79321	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGCATTTAAAAAATTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.147967299	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597111	171597131	170740601	170740621	79322	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCTCTGGAGGTGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.243540903	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597118	171597138	170740608	170740628	79323	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTGGTTGTCTCTGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.112989645	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597119	171597139	170740609	170740629	79324	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGTGGTTGTCTCTGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.362884388	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597125	171597145	170740615	170740635	79325	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGGTAAGGTGGTTGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.02306602	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597164	171597184	170740654	170740674	79326	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGAAGGAGGAAACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.465991217	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597233	171597253	170740723	170740743	79327	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTGCAGTGCATACATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.456444576	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597305	171597325	170740795	170740815	79328	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCTGCCCAGGGCATCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.581798642	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597308	171597328	170740798	170740818	79329	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTGGGATGCCCTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.260129725	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597309	171597329	170740799	170740819	79330	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCACTGGGATGCCCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.625473881	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597313	171597333	170740803	170740823	79331	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTCACCACTGGGATGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.470265756	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597314	171597334	170740804	170740824	79332	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTCACCACTGGGATGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.083664401	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597323	171597343	170740813	170740833	79333	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACACTCAGTCAGTCACCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054551706	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597324	171597344	170740814	170740834	79334	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACACTCAGTCAGTCACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.023727534	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597330	171597350	170740820	170740840	79335	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGACTGAGTGTGAGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.481390896	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597342	171597362	170740832	170740852	79336	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGCATGTGGTTCCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.537894465	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597352	171597372	170740842	170740862	79337	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCACCGCAGGAGCCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.111399891	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597358	171597378	170740848	170740868	79338	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCCTGATGGCTCCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114687373	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597361	171597381	170740851	170740871	79339	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGTGGCCTGATGGCTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.427439466	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597370	171597390	170740860	170740880	79340	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGGCCACATGCCTAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.404311077	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597370	171597390	170740860	170740880	79341	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTAGGCATGTGGCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.331818575	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597378	171597398	170740868	170740888	79342	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAAGCCAGATCTAGGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339940526	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597382	171597402	170740872	170740892	79343	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTAGATCTGGCTTCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.494211306	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597385	171597405	170740875	170740895	79344	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTGGGGAAGCCAGATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.12535294	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597392	171597412	170740882	170740902	79345	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTCCCCAGTGGCTACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.250190404	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597393	171597413	170740883	170740903	79346	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTCCCCAGTGGCTACCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.273753832	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597394	171597414	170740884	170740904	79347	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCCCAGTGGCTACCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248350677	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597399	171597419	170740889	170740909	79348	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCCCCTTTGGTAGCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073371604	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597399	171597419	170740889	170740909	79349	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGGCTACCAAAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.123321934	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597400	171597420	170740890	170740910	79350	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCCCCTTTGGTAGCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.163106134	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597401	171597421	170740891	170740911	79351	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGGCCCCTTTGGTAGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.330991485	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597411	171597431	170740901	170740921	79352	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGTGTCACCTGGCCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.221993597	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597412	171597432	170740902	170740922	79353	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGGCCAGGTGACACAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.298782951	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597420	171597440	170740910	170740930	79354	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACATCCGAGTTGTGTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.106989087	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597422	171597442	170740912	170740932	79355	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGACACAACTCGGATGTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.805144316	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597423	171597443	170740913	170740933	79356	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACACAACTCGGATGTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.591303706	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597458	171597478	170740948	170740968	79357	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGTCAAAATTTGCTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01797933	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597459	171597479	170740949	170740969	79358	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGGTCAAAATTTGCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.842036156	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597460	171597480	170740950	170740970	79359	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGGTCAAAATTTGCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.189599357	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597525	171597545	170741015	170741035	79360	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGTCGCTCAAAGGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048698924	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597526	171597546	170741016	170741036	79361	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGTCGCTCAAAGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.210775244	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597528	171597548	170741018	170741038	79362	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCCTTTGAGCGACTGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.570237873	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597529	171597549	170741019	170741039	79363	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGGACAGTCGCTCAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.060497978	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597533	171597553	170741023	170741043	79364	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCCTAGGACAGTCGCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.212327589	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597560	171597580	170741050	170741070	79365	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCATAAAGCCTGTCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.143791417	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597564	171597584	170741054	170741074	79366	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCTCTTTGGACAGGCTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090446688	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597572	171597592	170741062	170741082	79367	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAAAGGACCTCTTTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.58675413	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597577	171597597	170741067	170741087	79368	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGTCACAAAGGACCTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339587457	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597587	171597607	170741077	170741097	79369	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTGGCTGCTCAGTCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081567679	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597601	171597621	170741091	170741111	79370	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGCCACCTGCTGAGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.476325667	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597604	171597624	170741094	170741114	79371	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCGGTTTCTCAGCAGGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009267637	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597608	171597628	170741098	170741118	79372	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGCCGGTTTCTCAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.270003872	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597611	171597631	170741101	170741121	79373	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACAGAGCCGGTTTCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.265543864	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597623	171597643	170741113	170741133	79374	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCCACGAAAAAACAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.444400514	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597635	171597655	170741125	170741145	79375	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGTGGCTCTTCATGAAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.69209294	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597661	171597681	170741151	170741171	79376	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGTGATGAATGACTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096962757	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597680	171597700	170741170	170741190	79377	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGAATGGCAGCAAGTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.303373376	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597716	171597736	170741206	170741226	79378	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTGCGAGAGCCAGGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.170943448	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597718	171597738	170741208	170741228	79379	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCCCTGGCTCTCGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.671065094	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597719	171597739	170741209	170741229	79380	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCCTGGCTCTCGCAGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.163595815	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597723	171597743	170741213	170741233	79381	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCCAGCTCTGCGAGAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.382283346	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597724	171597744	170741214	170741234	79382	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCCAGCTCTGCGAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.248675462	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597764	171597784	170741254	170741274	79383	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAGCACTTAAGCTTTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.486109593	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597765	171597785	170741255	170741275	79384	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGCACTTAAGCTTTGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.38545401	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597780	171597800	170741270	170741290	79385	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTCGGGCTCTGTGTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037510133	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597784	171597804	170741274	170741294	79386	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCCTAGAACACAGAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.113282106	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597884	171597904	170741374	170741394	79387	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGAAACAATGAATTAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.845897966	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597885	171597905	170741375	170741395	79388	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGAAACAATGAATTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.499613352	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597929	171597949	170741419	170741439	79389	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATTGAAAGTTGTAACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.920089558	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597981	171598001	170741471	170741491	79390	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAACAAGAGACTGGCTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105271826	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171597990	171598010	170741480	170741500	79391	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTATCAGAAACAAGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305824418	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598006	171598026	170741496	170741516	79392	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTTGCAAGATGAAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114103079	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598057	171598077	170741547	170741567	79393	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTTTGGAGGTGATCAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.719380181	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598061	171598081	170741551	170741571	79394	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAGGTTTGGAGGTGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.251932286	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598062	171598082	170741552	170741572	79395	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGAGGTTTGGAGGTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041339796	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598070	171598090	170741560	170741580	79396	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGATGACAGAGGTTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.28572504	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598073	171598093	170741563	170741583	79397	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGTATGATGACAGAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.069209297	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598078	171598098	170741568	170741588	79398	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGGTACAGTATGATGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.606302985	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598083	171598103	170741573	170741593	79399	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCATACTGTACCATCCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.456278911	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598097	171598117	170741587	170741607	79400	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGCTTTCAACCTTAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.083369696	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598160	171598180	170741650	170741670	79401	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAATTTAGAATCAGCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.618524149	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598219	171598239	170741709	170741729	79402	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAAACATTCACTGTTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.001757687	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598220	171598240	170741710	170741730	79403	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATAAACATTCACTGTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.387436577	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598259	171598279	170741749	170741769	79404	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCACAGTTCTCTAGGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.413850147	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598260	171598280	170741750	170741770	79405	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGTTCTCTAGGCTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375242681	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598270	171598290	170741760	170741780	79406	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGGCTCTAGGGATAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239714503	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598271	171598291	170741761	170741781	79407	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGGCTCTAGGGATAGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052836237	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598281	171598301	170741771	170741791	79408	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGATAGAACAGGGAATAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217942233	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598321	171598341	170741811	170741831	79409	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGAGCTTTCATTTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.120462324	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598364	171598384	170741854	170741874	79410	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGTAAACTATAGAGCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.391504888	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598365	171598385	170741855	170741875	79411	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTAAACTATAGAGCATGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.35510415	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598371	171598391	170741861	170741881	79412	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTATAGAGCATGCTGGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057896546	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598385	171598405	170741875	170741895	79413	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGTAATGGAAAGTACTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.729497222	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598386	171598406	170741876	170741896	79414	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTAATGGAAAGTACTAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.730911386	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598387	171598407	170741877	170741897	79415	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAATGGAAAGTACTAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023243811	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598399	171598419	170741889	170741909	79416	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTAAGAGGGGAATAAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.561589639	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598424	171598444	170741914	170741934	79417	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGAATAAGAGTCGATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.493256101	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598481	171598501	170741971	170741991	79418	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCTCTGAGAAGGTAACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.706656206	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598515	171598535	170742005	170742025	79419	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAGACAAGCAGCCATCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054646836	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598530	171598550	170742020	170742040	79420	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGAATGCTGTTCCAGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161024195	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598565	171598585	170742055	170742075	79421	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTACAATGGCCCTAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.036709397	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598579	171598599	170742069	170742089	79422	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAGCACACTCCTGTCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.134547045	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598580	171598600	170742070	170742090	79423	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAAGCACACTCCTGTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.530287315	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598597	171598617	170742087	170742107	79424	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGTATTCAAGCAACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.558472183	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598609	171598629	170742099	170742119	79425	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAACAGCAAGGAAGCTCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273717844	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598629	171598649	170742119	170742139	79426	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCTAGAGAAGATTGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.202267628	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598630	171598650	170742120	170742140	79427	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTAGAGAAGATTGACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.042852138	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598631	171598651	170742121	170742141	79428	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGAGAAGATTGACCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.039451944	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598632	171598652	170742122	170742142	79429	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGAGAAGATTGACCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025284976	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598642	171598662	170742132	170742152	79430	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTGACCAAGGGGGATAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.870224781	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598643	171598663	170742133	170742153	79431	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGACCAAGGGGGATAGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.272679655	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598644	171598664	170742134	170742154	79432	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCAAGGGGGATAGTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.369596701	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598649	171598669	170742139	170742159	79433	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCCCTCTACTATCCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.344226325	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598667	171598687	170742157	170742177	79434	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATAAAGACAGAGAAGTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024426776	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598668	171598688	170742158	170742178	79435	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAAAGACAGAGAAGTCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.439849704	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598680	171598700	170742170	170742190	79436	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTCATGGGGAGCAGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2005453	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598683	171598703	170742173	170742193	79437	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCATGGGGAGCAGATCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.386799814	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598684	171598704	170742174	170742194	79438	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGGGGAGCAGATCATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.58576972	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598704	171598724	170742194	170742214	79439	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGCCTTAGAAGTCAAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.151002518	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598711	171598731	170742201	170742221	79440	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAGTCAAAGCAAGGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.438370137	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598746	171598766	170742236	170742256	79441	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAGGCAGATAACCTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23690114	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598747	171598767	170742237	170742257	79442	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGGCAGATAACCTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.740158643	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598762	171598782	170742252	170742272	79443	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTGCTCAAACCCTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073593152	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598763	171598783	170742253	170742273	79444	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGGGTTTGAGCAGTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.722080312	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598768	171598788	170742258	170742278	79445	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTTTGAGCAGTGGATGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126965034	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598796	171598816	170742286	170742306	79446	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTCATGTTCACGTGTACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.38593176	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598801	171598821	170742291	170742311	79447	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACGTGAACATGACCCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.626147767	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598817	171598837	170742307	170742327	79448	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTATCACAGTATCCAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13911459	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598818	171598838	170742308	170742328	79449	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTTATCACAGTATCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.637198294	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598827	171598847	170742317	170742337	79450	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGATAAGAAGAGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.270564472	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598828	171598848	170742318	170742338	79451	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGATAAGAAGAGACTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.08277597	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598830	171598850	170742320	170742340	79452	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGATAAGAAGAGACTGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428215787	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598857	171598877	170742347	170742367	79453	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAAGCAGGAAAAGTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07604159	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598858	171598878	170742348	170742368	79454	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAAGCAGGAAAAGTAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.398533297	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598883	171598903	170742373	170742393	79455	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCGAAACAATCTAAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.027170035	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598890	171598910	170742380	170742400	79456	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAATCTAAGCAAAGGATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.12870225	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598893	171598913	170742383	170742403	79457	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTAAGCAAAGGATGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.798835348	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598904	171598924	170742394	170742414	79458	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGATGATGGTGGCCTGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.963606226	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598905	171598925	170742395	170742415	79459	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGATGGTGGCCTGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371510307	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598911	171598931	170742401	170742421	79460	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGGCCTGAAGTAGGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.198679513	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598919	171598939	170742409	170742429	79461	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTGCCATCACCCTACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.165828241	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598920	171598940	170742410	170742430	79462	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTAGGGTGATGGCAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.175855129	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598945	171598965	170742435	170742455	79463	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGAGAAGAGGTCAGAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.386245116	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598976	171598996	170742466	170742486	79464	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGTAGAGCCAATATGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.388103423	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598987	171599007	170742477	170742497	79465	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATATGATTGGTGAATGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.717549868	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171598989	171599009	170742479	170742499	79466	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATCATTCACCAATCATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.281956571	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599021	171599041	170742511	170742531	79467	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGCAGTCAAGATGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078091837	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599022	171599042	170742512	170742532	79468	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGCAGTCAAGATGACTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.43532883	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599042	171599062	170742532	170742552	79469	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTGCTCAGGTAAAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057881753	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599054	171599074	170742544	170742564	79470	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTGCTCTTCCAGGTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.20235631	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599062	171599082	170742552	170742572	79471	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGACAACTCTGCTCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.156518782	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599064	171599084	170742554	170742574	79472	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGAGCAGAGTTGTCACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.067491201	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599070	171599090	170742560	170742580	79473	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAGTTGTCACATAAGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.041809743	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599083	171599103	170742573	170742593	79474	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGAGACGGAGAAGACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283160438	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599084	171599104	170742574	170742594	79475	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAGACGGAGAAGACTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003418886	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599113	171599133	170742603	170742623	79476	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTTTAAAAGAAAAGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.339330826	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599150	171599170	170742640	170742660	79477	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATAAAACAGCAACTCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.389052601	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599469	171599489	170742959	170742979	79478	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGACAATTAAAACAGCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.594400376	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599588	171599608	170743078	170743098	79479	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTGAGCAGTTCTTGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.341813106	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599630	171599650	170743120	170743140	79480	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTTTCAGAGCTAAAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.017262523	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599651	171599671	170743141	170743161	79481	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGATTTGCCAGGACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049126315	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599652	171599672	170743142	170743162	79482	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAGGGATTTGCCAGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024544801	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599654	171599674	170743144	170743164	79483	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTGGCAAATCCCTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.245770076	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599659	171599679	170743149	170743169	79484	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCCTTGGGAGGGATTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.090447546	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599669	171599689	170743159	170743179	79485	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACGTTTCATATCCTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.50321111	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599670	171599690	170743160	170743180	79486	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCAAGGATATGAAACGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.2114005	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599670	171599690	170743160	170743180	79487	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACGTTTCATATCCTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.566611564	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599673	171599693	170743163	170743183	79488	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGAACGTTTCATATCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.010586711	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599674	171599694	170743164	170743184	79489	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCAGAACGTTTCATATCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153201413	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599683	171599703	170743173	170743193	79490	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACGTTCTGGTTGTCAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.447591684	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599684	171599704	170743174	170743194	79491	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACGTTCTGGTTGTCAGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.211190365	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599685	171599705	170743175	170743195	79492	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGTTCTGGTTGTCAGTAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.778880596	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599686	171599706	170743176	170743196	79493	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCTGGTTGTCAGTAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105959775	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599696	171599716	170743186	170743206	79494	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGTAACGGGGGCAGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.746748247	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599723	171599743	170743213	170743233	79495	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAATACAAAACCTATACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099975946	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599772	171599792	170743262	170743282	79496	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTTAACACTATAAATAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2769408	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599797	171599817	170743287	170743307	79497	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCATAGACTCTCTGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.55263636	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599798	171599818	170743288	170743308	79498	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCATAGACTCTCTGCCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.031098251	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599816	171599836	170743306	170743326	79499	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGTGATAGTGACTCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.208171078	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599844	171599864	170743334	170743354	79500	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTTGCCAACCTCAGTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.588615839	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599849	171599869	170743339	170743359	79501	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTACTGTTGCCAACCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.560920775	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599852	171599872	170743342	170743362	79502	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTTGGCAACAGTAGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.220902746	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599878	171599898	170743368	170743388	79503	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACATAATGGATCACCCATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.326018742	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599894	171599914	170743384	170743404	79504	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTGAAGTGATGCCACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.249767243	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599895	171599915	170743385	170743405	79505	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACTTGAAGTGATGCCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.192871592	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599897	171599917	170743387	170743407	79506	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCATCACTTCAAGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137949377	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599929	171599949	170743419	170743439	79507	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACAACTTGAGTTGCAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.188875834	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599930	171599950	170743420	170743440	79508	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAACTTGAGTTGCAATTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078818339	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599974	171599994	170743464	170743484	79509	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAACGGTTAATCTATAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.326864817	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171599979	171599999	170743469	170743489	79510	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGCACAACGGTTAATCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105135072	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600262	171600282	170743752	170743772	79511	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGACATTGGGTGGGGCGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150243781	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600270	171600290	170743760	170743780	79512	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAATCTTCAGACATTGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.152880346	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600271	171600291	170743761	170743781	79513	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAATCTTCAGACATTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.35311194	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600272	171600292	170743762	170743782	79514	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTAATCTTCAGACATTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.312236439	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600275	171600295	170743765	170743785	79515	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGTAATCTTCAGACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178063266	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600276	171600296	170743766	170743786	79516	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCACAGTAATCTTCAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.074926863	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600282	171600302	170743772	170743792	79517	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGATTACTGTGACCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.284617336	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600291	171600311	170743781	170743801	79518	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGACCACTCTGGAGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.115785028	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600299	171600319	170743789	170743809	79519	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTATCCTAGTTCTCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055477111	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600322	171600342	170743812	170743832	79520	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTGAACTGAACTTTGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.627061304	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600323	171600343	170743813	170743833	79521	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTGAACTGAACTTTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119413051	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600327	171600347	170743817	170743837	79522	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAACATCTGAACTGAACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115168501	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600328	171600348	170743818	170743838	79523	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTAACATCTGAACTGAACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.405363326	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600361	171600381	170743851	170743871	79524	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTACACCTCAAGAGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.270293953	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600366	171600386	170743856	170743876	79525	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACCTCAAGAGATAACGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119278315	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600395	171600415	170743885	170743905	79526	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTACATACTTGAAGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.076955631	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600410	171600430	170743900	170743920	79527	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCTGGGGAAAGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.544337913	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600432	171600452	170743922	170743942	79528	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTCTCTGTAAATCCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.205426124	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600436	171600456	170743926	170743946	79529	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCATTCTGGATTTACAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195945282	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600449	171600469	170743939	170743959	79530	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGCTCTCTCAAGCCATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.008930899	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600491	171600511	170743981	170744001	79531	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTATTGCAGTTAGGGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.684610575	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600515	171600535	170744005	170744025	79532	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGGGGTGAGGGCTCCCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.277014727	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600516	171600536	170744006	170744026	79533	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGGTGAGGGCTCCCCCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.379661203	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600519	171600539	170744009	170744029	79534	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGGGCTCCCCCGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191994121	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600531	171600551	170744021	170744041	79535	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACATAAGCTCCTCCCAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.270750379	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600532	171600552	170744022	170744042	79536	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACATAAGCTCCTCCCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.666079784	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600533	171600553	170744023	170744043	79537	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTACATAAGCTCCTCCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093949619	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600534	171600554	170744024	170744044	79538	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTACATAAGCTCCTCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130559523	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600586	171600606	170744076	170744096	79539	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAGCTGATAAGAAAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.443668656	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600587	171600607	170744077	170744097	79540	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCAAGCTGATAAGAAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.754130146	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600591	171600611	170744081	170744101	79541	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGGGCAAGCTGATAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.317109698	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600593	171600613	170744083	170744103	79542	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTATCAGCTTGCCCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.218946521	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600608	171600628	170744098	170744118	79543	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCTGTCTGCCCCACACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.613908838	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600609	171600629	170744099	170744119	79544	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTCTGTCTGCCCCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.569129555	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600655	171600675	170744145	170744165	79545	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGTCAAACGCCAAAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.032124504	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600670	171600690	170744160	170744180	79546	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGAGTCTGGTTCCACTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.432952943	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600683	171600703	170744173	170744193	79547	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCTCTGGAATAAGGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.098518248	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600690	171600710	170744180	170744200	79548	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGCACTCTCTCTGGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.408508925	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600697	171600717	170744187	170744207	79549	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTAAACTAGCACTCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136726918	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600793	171600813	170744283	170744303	79550	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCGAGATCTGGGTCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.304561146	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600796	171600816	170744286	170744306	79551	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGACCCAGATCTCGCTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.12514219	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600856	171600876	170744346	170744366	79552	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGACACATACGACTTGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.745349044	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600857	171600877	170744347	170744367	79553	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGACACATACGACTTGATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.117535108	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600860	171600880	170744350	170744370	79554	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACATACGACTTGATTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252511016	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600876	171600896	170744366	170744386	79555	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGAGGTAAGTCGCCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004862841	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600910	171600930	170744400	170744420	79556	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAATATGCAGAAAACAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.468495985	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600915	171600935	170744405	170744425	79557	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCAGAAAACAGCTTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.594569378	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600916	171600936	170744406	170744426	79558	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAAAACAGCTTTGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125712668	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600924	171600944	170744414	170744434	79559	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCTTTGGCCTGGGCGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.260902039	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600930	171600950	170744420	170744440	79560	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGCCTGGGCGTTGCGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084031048	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600951	171600971	170744441	170744461	79561	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGATTGCGAAAACACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.316950493	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600958	171600978	170744448	170744468	79562	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGAAAACACATGTGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.410369084	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600973	171600993	170744463	170744483	79563	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACGCTGGATTTCACAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.258374015	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600974	171600994	170744464	170744484	79564	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACGCTGGATTTCACAATTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186912502	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171600985	171601005	170744475	170744495	79565	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAATTCTGGGATTAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371313779	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601008	171601028	170744498	170744518	79566	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGAATTTCTAAATCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.894483661	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601070	171601090	170744560	170744580	79567	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGAACAGTGACCACTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012508823	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601075	171601095	170744565	170744585	79568	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGACCACTGAATTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15769868	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601076	171601096	170744566	170744586	79569	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTGACCACTGAATTGGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103147172	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601084	171601104	170744574	170744594	79570	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGCCCATACCAATTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.460289522	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601176	171601196	170744666	170744686	79571	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAGCTTCAGCTTGCGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.047453424	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601185	171601205	170744675	170744695	79572	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAAGCTATAATGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.232853248	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601186	171601206	170744676	170744696	79573	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAAGCTATAATGTCCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.217363764	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601197	171601217	170744687	170744707	79574	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGTCCTGTGGGCAAACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.504612535	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601198	171601218	170744688	170744708	79575	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCCTGTGGGCAAACAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.234933907	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601199	171601219	170744689	170744709	79576	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTGTGGGCAAACAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.725592721	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601200	171601220	170744690	170744710	79577	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTGTGGGCAAACAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274005074	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601223	171601243	170744713	170744733	79578	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATTTGAGAACTGACATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.572458859	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601236	171601256	170744726	170744746	79579	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACATGTTGGCCCCTGTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223152878	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601244	171601264	170744734	170744754	79580	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCCCCTGTAATAGGTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000943734	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601245	171601265	170744735	170744755	79581	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCCTGTAATAGGTTGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.212843432	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601249	171601269	170744739	170744759	79582	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCTAGCAACCTATTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.232491848	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601250	171601270	170744740	170744760	79583	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCCCTAGCAACCTATTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134279651	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601251	171601271	170744741	170744761	79584	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGCCCTAGCAACCTATTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.463143186	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601276	171601296	170744766	170744786	79585	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCAAGTACCACAAAACAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.485783053	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601317	171601337	170744807	170744827	79586	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTCTCATAGTTCTGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122336625	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601321	171601341	170744811	170744831	79587	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCTTCTCCAGAACTATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.711968887	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601334	171601354	170744824	170744844	79588	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAGGAAACTCTGCAATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.302978339	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601362	171601382	170744852	170744872	79589	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGACTGTGCTCCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032618394	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601369	171601389	170744859	170744879	79590	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTGCTCCCTCCGAGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.567125886	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601370	171601390	170744860	170744880	79591	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCTCCCTCCGAGGTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.53768261	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601378	171601398	170744868	170744888	79592	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCATCCCTAGAACCTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.276374385	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601379	171601399	170744869	170744889	79593	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCATCCCTAGAACCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005422847	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601382	171601402	170744872	170744892	79594	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGGTTCATCCCTAGAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.128779431	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601401	171601421	170744891	170744911	79595	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGGATGGAGGCATGCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.544504659	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601412	171601432	170744902	170744922	79596	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTACCTGAAGCTAGGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299746746	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601414	171601434	170744904	170744924	79597	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCCTAGCTTCAGGTAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320319459	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601424	171601444	170744914	170744934	79598	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGTAATCCTGGCAGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.079951829	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601435	171601455	170744925	170744945	79599	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGCATGCCAAGGACTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05708594	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601444	171601464	170744934	170744954	79600	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTCAGGTGAAGGCATGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104482638	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601454	171601474	170744944	170744964	79601	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATACTGTAGCTTCAGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.182888597	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601460	171601480	170744950	170744970	79602	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTGGAATACTGTAGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.080334362	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601478	171601498	170744968	170744988	79603	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTCTCCTTCCAGCCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.544815836	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601486	171601506	170744976	170744996	79604	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGATTCCAGGTGAGGCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.147926674	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601490	171601510	170744980	170745000	79605	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGTGTGATTCCAGGTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115639923	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601494	171601514	170744984	170745004	79606	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGACGTGTGATTCCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.43083369	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601499	171601519	170744989	170745009	79607	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACGGAAGACGTGTGATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139202976	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601561	171601581	170745051	170745071	79608	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATAACTGCTGTCCTTAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084617672	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601562	171601582	170745052	170745072	79609	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATATAACTGCTGTCCTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.393075972	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601716	171601736	170745206	170745226	79610	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCAACACAGTACAGCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.066014124	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601732	171601752	170745222	170745242	79611	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTTTGGAACTCATCTCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.536495419	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601734	171601754	170745224	170745244	79612	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGATGAGATGAGTTCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.049669293	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601735	171601755	170745225	170745245	79613	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTGATGAGATGAGTTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.499443144	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601763	171601783	170745253	170745273	79614	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTATAGGAGGCATGATCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.494752533	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601829	171601849	170745319	170745339	79615	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATTAAAGTAACTAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.709518516	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601964	171601984	170745454	170745474	79616	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAATATGCAGATAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077155555	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601976	171601996	170745466	170745486	79617	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATTCAGCAGAAAGTGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105957008	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601977	171601997	170745467	170745487	79618	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCAGCAGAAAGTGCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.391583788	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601987	171602007	170745477	170745497	79619	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTGCTGCTGGGAAAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000949559	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171601988	171602008	170745478	170745498	79620	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTGCTGCTGGGAAAATCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.715990383	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602008	171602028	170745498	170745518	79621	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAAACAGAATGGAATTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.297942828	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602019	171602039	170745509	170745529	79622	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATAGAAGTTTATAAACAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.485644802	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602102	171602122	170745592	170745612	79623	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTTACCACTGCATAAAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099463202	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602106	171602126	170745596	170745616	79624	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCACTGCATAAAAGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.259871649	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602125	171602145	170745615	170745635	79625	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGATGTCGTAAAAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229493317	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602160	171602180	170745650	170745670	79626	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATATTATTGAAAAAGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.621311683	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602161	171602181	170745651	170745671	79627	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATTATTGAAAAAGGCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.285741033	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602484	171602504	170745974	170745994	79628	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAAAACCTACCATATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.173313144	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602492	171602512	170745982	170746002	79629	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTACCATATCACAGGACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207361018	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602663	171602683	170746153	170746173	79630	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAACAAATTGCTGTATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019264277	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602745	171602765	170746235	170746255	79631	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTAGAAGTAATTAACAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.367355385	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171602918	171602938	170746408	170746428	79632	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGATATATAATGCAATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208004886	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603286	171603306	170746776	170746796	79633	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAATGGTTGCTAGTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.566241181	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603287	171603307	170746777	170746797	79634	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAAATGGTTGCTAGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006000883	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603291	171603311	170746781	170746801	79635	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATTAAAAAATGGTTGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.059383434	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603301	171603321	170746791	170746811	79636	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCTACCTCCTATTAAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.18022238	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603492	171603512	170746982	170747002	79637	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAATCATTCCAGTTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.141226241	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603505	171603525	170746995	170747015	79638	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACAATTCTTCCACTGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198291052	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603537	171603557	170747027	170747047	79639	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACTGATTTGCTATTCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.596375724	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603571	171603591	170747061	170747081	79640	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAGCTAATAACATAGCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283153904	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603847	171603867	170747337	170747357	79641	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTAGTGAGAAATATTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041128069	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603852	171603872	170747342	170747362	79642	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGATGATTAGTGAGAAATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.996121055	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603884	171603904	170747374	170747394	79643	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCACTCTTGGGGGAGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.752437648	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603894	171603914	170747384	170747404	79644	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAGAATGCATCACTCTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.453802129	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603895	171603915	170747385	170747405	79645	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAAGAATGCATCACTCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375768722	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603896	171603916	170747386	170747406	79646	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAAGAATGCATCACTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005044575	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603897	171603917	170747387	170747407	79647	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCAAGAATGCATCACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.092194204	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603907	171603927	170747397	170747417	79648	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCTTGACAAAAAAAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.052792656	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603960	171603980	170747450	170747470	79649	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACCCTACTCTACAATGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033172585	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603962	171603982	170747452	170747472	79650	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTATACATTGTAGAGTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.564505612	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603982	171604002	170747472	170747492	79651	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACTGAAAACACTTCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.469476105	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171603983	171604003	170747473	170747493	79652	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACTGAAAACACTTCAATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.093368717	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604008	171604028	170747498	170747518	79653	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATGCTGACTTCCCTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.168428439	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604067	171604087	170747557	170747577	79654	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCTTGATCAGAGGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.053943198	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604068	171604088	170747558	170747578	79655	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTCTTGATCAGAGGTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124438663	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604081	171604101	170747571	170747591	79656	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGACAGGGAACTGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.653371434	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604092	171604112	170747582	170747602	79657	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGCCCTGTGGCTTAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050877173	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604095	171604115	170747585	170747605	79658	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCCTGTGGCTTAGCCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.733508787	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604099	171604119	170747589	170747609	79659	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCACCTGGGCTAAGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.020236637	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604100	171604120	170747590	170747610	79660	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTACCACCTGGGCTAAGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.218517026	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604111	171604131	170747601	170747621	79661	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGTGGTATTGAGATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239065472	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604112	171604132	170747602	170747622	79662	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGGATCTCAATACCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.581361437	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604112	171604132	170747602	170747622	79663	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTGGTATTGAGATCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.735991683	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604113	171604133	170747603	170747623	79664	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGAGGATCTCAATACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.222558532	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604127	171604147	170747617	170747637	79665	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCTCAGGGCCACCCTGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400946163	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604130	171604150	170747620	170747640	79666	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGGCCACCCTGAGATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.557552158	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604130	171604150	170747620	170747640	79667	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAATCTCAGGGTGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.572756011	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604131	171604151	170747621	170747641	79668	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGCCACCCTGAGATTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087660923	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604132	171604152	170747622	170747642	79669	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGCCACCCTGAGATTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.554490138	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604133	171604153	170747623	170747643	79670	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCCACCCTGAGATTGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.310133504	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604138	171604158	170747628	170747648	79671	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACCCCCTCCAATCTCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034738869	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604141	171604161	170747631	170747651	79672	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCACCCCCTCCAATCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099566006	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604142	171604162	170747632	170747652	79673	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCTCACCCCCTCCAATCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.118800459	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604169	171604189	170747659	170747679	79674	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCTCTCACTGTGCAAAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.059078514	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604214	171604234	170747704	170747724	79675	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAACCCCATGTAGATGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05570744	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604220	171604240	170747710	170747730	79676	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCATGTAGATGTTGAGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.292286646	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604221	171604241	170747711	170747731	79677	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGATCCTCAACATCTACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.058604924	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604222	171604242	170747712	170747732	79678	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGATCCTCAACATCTACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191621702	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604223	171604243	170747713	170747733	79679	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAGATCCTCAACATCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133659246	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604255	171604275	170747745	170747765	79680	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAAGGAGAAAAGAGTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.693777072	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604256	171604276	170747746	170747766	79681	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACCAAGGAGAAAAGAGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.328535834	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604272	171604292	170747762	170747782	79682	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAACTGCGATGGCTTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.189727985	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604286	171604306	170747776	170747796	79683	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGTTTGAAAACCACTGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.4377947	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604294	171604314	170747784	170747804	79684	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACCACTGGTACAGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.932282931	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604299	171604319	170747789	170747809	79685	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTCCTTCTCTCCTGTACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.396202036	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604320	171604340	170747810	170747830	79686	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGACAGACTGAGCACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102700391	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604328	171604348	170747818	170747838	79687	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTGAGCACATGTGGTATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.213820728	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604331	171604351	170747821	170747841	79688	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCACATGTGGTATGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.129399284	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604332	171604352	170747822	170747842	79689	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCACATGTGGTATGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000508596	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604343	171604363	170747833	170747853	79690	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATGAGGGAGGGCTGCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.192883429	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604344	171604364	170747834	170747854	79691	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGAGGGAGGGCTGCACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.56993598	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604363	171604383	170747853	170747873	79692	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGTCTCCTGAGATTAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.394873688	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604384	171604404	170747874	170747894	79693	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAAGAATCTGAAGTGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.838522482	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604420	171604440	170747910	170747930	79694	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACAGCAGACTGCGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221051099	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604426	171604446	170747916	170747936	79695	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTCTGCTGTGCTGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047918717	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604427	171604447	170747917	170747937	79696	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGTATCAGCACAGCAGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.943216331	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604434	171604454	170747924	170747944	79697	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGCTGATACAGGCATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036033704	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604448	171604468	170747938	170747958	79698	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGAAGGAGTCAGAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.105965157	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604459	171604479	170747949	170747969	79699	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGAGATCTGGATTTAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021468811	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604460	171604480	170747950	170747970	79700	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAGATCTGGATTTAACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.497835716	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604480	171604500	170747970	170747990	79701	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTGGTTAAATCTACAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.380314391	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604498	171604518	170747988	170748008	79702	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTCTCAAAACTACTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.424556708	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604512	171604532	170748002	170748022	79703	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAATTTAAAGATGTGATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299535966	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604531	171604551	170748021	170748041	79704	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGCCAACAATGAACAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142471974	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604606	171604626	170748096	170748116	79705	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCGTGTTGCTGCACAATCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.226553908	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604647	171604667	170748137	170748157	79706	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTTAGAGAGCATGATGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.095375666	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604675	171604695	170748165	170748185	79707	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGACTTATCAGGAACATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.118670942	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604686	171604706	170748176	170748196	79708	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGGGTAATGGACTTATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.331764554	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604695	171604715	170748185	170748205	79709	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTACCCATGCAGAAGCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.277585468	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604696	171604716	170748186	170748206	79710	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTACCCATGCAGAAGCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.619279381	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604703	171604723	170748193	170748213	79711	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAATCCCTTATGCTTCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.426780763	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604705	171604725	170748195	170748215	79712	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGAAGCATAAGGGATTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085949656	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604716	171604736	170748206	170748226	79713	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGATTTAAAGGTATATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.139615607	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604717	171604737	170748207	170748227	79714	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGATTTAAAGGTATATGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.205122721	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604737	171604757	170748227	170748247	79715	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGAGTGATTAAAATGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057116608	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171604986	171605006	170748476	170748496	79716	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGGCTGTATGAGCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06491056	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605092	171605112	170748582	170748602	79717	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTAGGTAAGAAAGGCTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.632706737	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605100	171605120	170748590	170748610	79718	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAAAGGCTGTGAGGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.570331663	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605101	171605121	170748591	170748611	79719	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGGCTGTGAGGACCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044519444	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605102	171605122	170748592	170748612	79720	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAGGCTGTGAGGACCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.029405162	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605105	171605125	170748595	170748615	79721	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGCTGTGAGGACCCTAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.645279665	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605106	171605126	170748596	170748616	79722	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGAGGACCCTAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.507840624	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605107	171605127	170748597	170748617	79723	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGTGAGGACCCTAGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.886836831	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605119	171605139	170748609	170748629	79724	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACCTTCTCCCCTCCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.396381159	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605120	171605140	170748610	170748630	79725	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAACCTTCTCCCCTCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236409749	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605126	171605146	170748616	170748636	79726	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGGGAGAAGGTTCAGTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.101482693	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605157	171605177	170748647	170748667	79727	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGTGAATTAAAAGTTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.136401806	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605158	171605178	170748648	170748668	79728	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGTGAATTAAAAGTTTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.309188172	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605162	171605182	170748652	170748672	79729	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATTAAAAGTTTAGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.100124059	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605177	171605197	170748667	170748687	79730	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGAAGGAAAAGTTATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.443091166	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605180	171605200	170748670	170748690	79731	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGGAAAAGTTATTAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.449737395	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605191	171605211	170748681	170748701	79732	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATTAGAGGTGGAGTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.62445064	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605225	171605245	170748715	170748735	79733	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAATAATGTTCAGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.699783491	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605226	171605246	170748716	170748736	79734	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAATAATGTTCAGCGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.418547565	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605238	171605258	170748728	170748748	79735	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGCGAACAGGGTGATTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.732577977	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605247	171605267	170748737	170748757	79736	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGATTAAAATGGAAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.459810812	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605250	171605270	170748740	170748760	79737	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTAAAATGGAAATTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.367989941	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605280	171605300	170748770	170748790	79738	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGATTGATAATAAAATCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.272973905	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605556	171605576	170749046	170749066	79739	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTGCAGCCTTGAATGTGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041440989	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605587	171605607	170749077	170749097	79740	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCACATTGCTGCACTGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.10847864	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605703	171605723	170749193	170749213	79741	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATACAAATGATAGAATTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.883524678	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605709	171605729	170749199	170749219	79742	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATGATAGAATTCGTGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161820855	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605710	171605730	170749200	170749220	79743	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATGATAGAATTCGTGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.788314004	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605759	171605779	170749249	170749269	79744	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCATCAAGAAGCTAGAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.653761115	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605783	171605803	170749273	170749293	79745	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGAGCATGTAATTGAAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283809083	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605859	171605879	170749349	170749369	79746	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATATGAAAAACACACAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.476678232	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605860	171605880	170749350	170749370	79747	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATATGAAAAACACACAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183670713	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171605996	171606016	170749486	170749506	79748	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACAGAATATCAGCAAGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.283657877	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606002	171606022	170749492	170749512	79749	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTATCAGCAAGCTGTGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.389479495	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606003	171606023	170749493	170749513	79750	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATCAGCAAGCTGTGGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342100518	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606004	171606024	170749494	170749514	79751	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCAGCAAGCTGTGGGACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.469405802	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606079	171606099	170749569	170749589	79752	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATCGTATGTCAAGTAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.511877519	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606177	171606197	170749667	170749687	79753	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGCTATAAACTGCCCCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.303703367	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606178	171606198	170749668	170749688	79754	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCTATAAACTGCCCCAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052040725	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606382	171606402	170749872	170749892	79755	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTCATTCCCTATCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.066472926	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606386	171606406	170749876	170749896	79756	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATTCCCTATCAGAACAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.247672447	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606387	171606407	170749877	170749897	79757	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GATTCCCTATCAGAACAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.761407957	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606388	171606408	170749878	170749898	79758	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTTCCCTATCAGAACAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.026355092	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606389	171606409	170749879	170749899	79759	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCCTATCAGAACAGGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.614169328	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606393	171606413	170749883	170749903	79760	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTCCCCCATCCTGTTCTGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.222186844	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606417	171606437	170749907	170749927	79761	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGAATAATCGGATCATGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.454449527	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606420	171606440	170749910	170749930	79762	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GGTGGAATAATCGGATCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.27681693	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606420	171606440	170749910	170749930	79763	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCATGATCCGATTATTCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.140482585	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606421	171606441	170749911	170749931	79764	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGTGGAATAATCGGATCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.816356004	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606422	171606442	170749912	170749932	79765	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAGGTGGAATAATCGGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.471195359	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606429	171606449	170749919	170749939	79766	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTGGGACCAGGTGGAATAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286160283	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606532	171606552	170750022	170750042	79767	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAACCTCAAGCATAAGAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.486527809	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606549	171606569	170750039	170750059	79768	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GACTTGGAAGAAACTACATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.298499921	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606611	171606631	170750101	170750121	79769	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGAATCATAAAAGCAGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.574142894	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606688	171606708	170750178	170750198	79770	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAACAATGCAAGTGTAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.543020986	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606698	171606718	170750188	170750208	79771	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAGTGTAGCATGGCAAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.465134933	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606711	171606731	170750201	170750221	79772	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCAAATGAAGGTGCAAGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111833081	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606746	171606766	170750236	170750256	79773	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GTAATGTCCTGAAGGGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.736210957	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606761	171606781	170750251	170750271	79774	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAGGGAAGGAGAGGGAATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.031404188	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606806	171606826	170750296	170750316	79775	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GCCAAAATCTCTGTGAAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.469230184	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606810	171606830	170750300	170750320	79776	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAATCTCTGTGAAAAAACGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.260827598	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606819	171606839	170750309	170750329	79777	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAAACGGAAGGCAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.01265377	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606820	171606840	170750310	170750330	79778	hg19	N/A	enh19014	N/A	Enhatls103717	enhancer	enh				GAAAAAACGGAAGGCAAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.210219541	SP5	chr2	170715336	170718078	13538				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606910	171606930	170750400	170750420	79779	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGTAATCCTTCAAGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.206662629	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606948	171606968	170750438	170750458	79780	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAAATCTGCAACTACATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.907810794	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606963	171606983	170750453	170750473	79781	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATAAAGGAATGAAGTATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.227160993	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606969	171606989	170750459	170750479	79782	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAATGAAGTATAGTGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.925604278	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606980	171607000	170750470	170750490	79783	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGTGGAGATGGTAACTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.91724746	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171606981	171607001	170750471	170750491	79784	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTGGAGATGGTAACTATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.474344743	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607122	171607142	170750612	170750632	79785	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATAACACATATAGAAATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.174885467	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607149	171607169	170750639	170750659	79786	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAAAGCACAAAGGACAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.413204111	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607301	171607321	170750791	170750811	79787	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTATACTAATAAACCAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.611976168	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607459	171607479	170750949	170750969	79788	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGTGGTCTAAACAATTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.790136548	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607476	171607496	170750966	170750986	79789	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAAGGCGAAGATATAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.516369954	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607485	171607505	170750975	170750995	79790	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGATATAAGACTGGTTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122584891	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607514	171607534	170751004	170751024	79791	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAATCTATTCTAACTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253808115	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607515	171607535	170751005	170751025	79792	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAATCTATTCTAACTACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.605071396	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607534	171607554	170751024	170751044	79793	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGGACCAGCTTTATATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.061495254	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607581	171607601	170751071	170751091	79794	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAAAAGATAGATCTATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.388194913	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607608	171607628	170751098	170751118	79795	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAAATCAAAAAAAGTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339034105	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607707	171607727	170751197	170751217	79796	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAATGATCAGTTTATCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.308936745	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607845	171607865	170751335	170751355	79797	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACCCTTCTTTCAATAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.015386608	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607852	171607872	170751342	170751362	79798	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTACCAATTATTGAAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.180552845	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607853	171607873	170751343	170751363	79799	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCTACCAATTATTGAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121912816	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607858	171607878	170751348	170751368	79800	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAATAATTGGTAGGATTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.026102783	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171607993	171608013	170751483	170751503	79801	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGCATCTAAAACATTTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044489649	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608009	171608029	170751499	170751519	79802	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACCAGGATAGACCATAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286521817	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608166	171608186	170751656	170751676	79803	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAGGTATTTAGAAGTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.529967873	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608195	171608215	170751685	170751705	79804	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATAAATGAAAAGGGAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.966123405	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608196	171608216	170751686	170751706	79805	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAAATGAAAAGGGAGCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.625279787	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608197	171608217	170751687	170751707	79806	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAAATGAAAAGGGAGCTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.989782071	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608200	171608220	170751690	170751710	79807	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAAAAGGGAGCTTAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.133992316	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608201	171608221	170751691	170751711	79808	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAAAAGGGAGCTTAGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.759896543	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608402	171608422	170751892	170751912	79809	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATACCCAAACAGAGGAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.882384458	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608409	171608429	170751899	170751919	79810	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGCCGGGTTTCCTCTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082201286	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608715	171608735	170752205	170752225	79811	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTAGAGCTTCATCCTCATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.137302121	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608716	171608736	170752206	170752226	79812	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTAGAGCTTCATCCTCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295178324	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171608996	171609016	170752486	170752506	79813	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAAAAATGCAAGGAGATGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.31610387	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609168	171609188	170752658	170752678	79814	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAGTCGCATGTCCTTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.054804366	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609231	171609251	170752721	170752741	79815	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATTATCAAAATTGGCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.512467097	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609240	171609260	170752730	170752750	79816	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATTGGCTTCCAGGCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.142295503	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609241	171609261	170752731	170752751	79817	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATTGGCTTCCAGGCTGTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.164051892	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609252	171609272	170752742	170752762	79818	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCGCTTGCCCATGACAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.239419203	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609643	171609663	170753133	170753153	79819	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACAATATTCAAAATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.139553711	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609737	171609757	170753227	170753247	79820	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCTCATGTCAATGATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.035253442	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171609762	171609782	170753252	170753272	79821	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTTAAGAAGAAACTTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.87029554	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610102	171610122	170753592	170753612	79822	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACCTCTAATTATACTGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096043133	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610359	171610379	170753849	170753869	79823	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACAAAGAAACTCCATGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.298002704	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610362	171610382	170753852	170753872	79824	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAGAAACTCCATGTCTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.052678861	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610372	171610392	170753862	170753882	79825	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCATGTCTAGGTGGCTTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.628027953	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610374	171610394	170753864	170753884	79826	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAGTGAAGCCACCTAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339250001	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610652	171610672	170754142	170754162	79827	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTAAACTGAACAAATTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.072846146	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610653	171610673	170754143	170754163	79828	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGTAAACTGAACAAATTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228821296	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610738	171610758	170754228	170754248	79829	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGGTACAGAAGAAGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169692066	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610775	171610795	170754265	170754285	79830	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTATTCCTGACAAAAATTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.030976172	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610784	171610804	170754274	170754294	79831	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAAAATTCTCAGGAATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186709348	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610805	171610825	170754295	170754315	79832	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAAACTTAAAATCTTATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.168170644	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610806	171610826	170754296	170754316	79833	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAACTTAAAATCTTATAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159021119	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610931	171610951	170754421	170754441	79834	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTTCTACACAGCATTATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.047413998	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610932	171610952	170754422	170754442	79835	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCATAATGCTGTGTAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.24159491	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171610934	171610954	170754424	170754444	79836	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTACACAGCATTATGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004568743	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611072	171611092	170754562	170754582	79837	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAATTCACAGAACAGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.440406514	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611256	171611276	170754746	170754766	79838	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGCGAAATCCCGTCCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014627557	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611257	171611277	170754747	170754767	79839	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGCGAAATCCCGTCCAGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.244440556	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611280	171611300	170754770	170754790	79840	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAAAGAGGGAGACCCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.218770043	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611284	171611304	170754774	170754794	79841	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAGGGAGACCCCAATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.667902412	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611285	171611305	170754775	170754795	79842	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGGAGACCCCAATTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.187238384	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611599	171611619	170755089	170755109	79843	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTGTACTTCTGTACACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.051933291	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611721	171611741	170755211	170755231	79844	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACTAGAAACTGCAAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.538096535	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611725	171611745	170755215	170755235	79845	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGAAACTGCAAAACATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.991431115	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171611726	171611746	170755216	170755236	79846	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAAACTGCAAAACATGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.996858225	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612184	171612204	170755674	170755694	79847	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTTAGCCACGCATGTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.244886034	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612193	171612213	170755683	170755703	79848	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGGGGCCTGTGAACATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221360703	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612329	171612349	170755819	170755839	79849	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGAAAAAAAGTCCGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.079249358	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612677	171612697	170756167	170756187	79850	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTGCAAGATAAATTATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216090135	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612714	171612734	170756204	170756224	79851	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGAGATATATAATCTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.285578938	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612715	171612735	170756205	170756225	79852	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGAGATATATAATCTTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.674957565	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612789	171612809	170756279	170756299	79853	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATTGCAATCAATAGTTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.610828025	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612906	171612926	170756396	170756416	79854	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCAAAAAAAAGAGTTGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.184717525	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171612907	171612927	170756397	170756417	79855	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGTCAAAAAAAAGAGTTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.360956749	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613086	171613106	170756576	170756596	79856	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGAGGTGGGTCTCTTTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.632515464	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613093	171613113	170756583	170756603	79857	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGGTCTCTTTGTGTGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299894041	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613346	171613366	170756836	170756856	79858	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAATAAATCAGTATATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.786388897	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613420	171613440	170756910	170756930	79859	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTTAACAAATAGTGCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.351319584	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613796	171613816	170757286	170757306	79860	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCACCACACCCAGCAAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.132786412	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171613802	171613822	170757292	170757312	79861	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATCCTGATCTTGCTGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.013020055	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171614434	171614454	170757924	170757944	79862	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGTACCATATAGAAAAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115383216	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171614484	171614504	170757974	170757994	79863	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACCTAAACATATGAAACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.154887745	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171614549	171614569	170758039	170758059	79864	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCTTACATATAAAACACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005333382	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171614554	171614574	170758044	170758064	79865	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACATATAAAACACACAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.120014169	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171614973	171614993	170758463	170758483	79866	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATGAAAAGGCAATATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141703993	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615068	171615088	170758558	170758578	79867	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTACATAACATTTAAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.190333785	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615090	171615110	170758580	170758600	79868	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGATTGCAGACAGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.1968845	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615312	171615332	170758802	170758822	79869	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACCACGCCCAGCTAGAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.566728326	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615321	171615341	170758811	170758831	79870	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAAACCCTGTCTCTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081597666	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615322	171615342	170758812	170758832	79871	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGAAACCCTGTCTCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.107307324	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615503	171615523	170758993	170759013	79872	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGTAACATGCTATTGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062376159	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615547	171615567	170759037	170759057	79873	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACACCTAGGCTGCATGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.058456314	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615600	171615620	170759090	170759110	79874	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACTCTAGGATGTTCCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.520798	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615696	171615716	170759186	170759206	79875	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCCATCTAAATAATTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.486516111	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615845	171615865	170759335	170759355	79876	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGCAACAGACCTAATAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.771878415	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615870	171615890	170759360	170759380	79877	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAATTTAAAAGACTGCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274762007	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171615889	171615909	170759379	170759399	79878	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGTTCAAGCGATTCTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040333837	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616002	171616022	170759492	170759512	79879	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACAAAAGACTGCCTATACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.230684586	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616013	171616033	170759503	170759523	79880	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTATACCTGGACTAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.385767039	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616017	171616037	170759507	170759527	79881	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCTCACTTAGTCCAGGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.010176423	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616028	171616048	170759518	170759538	79882	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGTGAGGAAGTAGACGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.560951162	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616132	171616152	170759622	170759642	79883	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAAACACATAGGAGTCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.547282035	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616142	171616162	170759632	170759652	79884	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACACATAGGGTAAACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048510592	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616154	171616174	170759644	170759664	79885	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACACATAGGAGTAACACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.449488309	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616155	171616175	170759645	170759665	79886	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAACACATAGGAGTAACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.372422915	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616168	171616188	170759658	170759678	79887	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACACATAGGGTAAACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.16238694	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616180	171616200	170759670	170759690	79888	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTTCACTTAGGGTACACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202425471	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616181	171616201	170759671	170759691	79889	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTTCACTTAGGGTACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.642298562	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616258	171616278	170759748	170759768	79890	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAAACAAAAAGACGTTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.709032339	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616577	171616597	170760067	170760087	79891	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACATGTACGACTTCAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.111278483	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616578	171616598	170760068	170760088	79892	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCACATGTACGACTTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.999030989	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616582	171616602	170760072	170760092	79893	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACATTCACATGTACGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.614226952	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616616	171616636	170760106	170760126	79894	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGTTTCTGGCTGTTACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.001747541	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616686	171616706	170760176	170760196	79895	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCATGCAATGGACTACTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.312308602	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616689	171616709	170760179	170760199	79896	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCAGGCAGTAGTCCATTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.890520994	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616767	171616787	170760257	170760277	79897	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAGTTAAAGAAGCTAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.661994443	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171616771	171616791	170760261	170760281	79898	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTAAAGAAGCTAGACAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.393526748	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617143	171617163	170760633	170760653	79899	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGAAAATACAAAGATCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.566001657	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617146	171617166	170760636	170760656	79900	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAATACAAAGATCTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.164349403	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617153	171617173	170760643	170760663	79901	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAAGATCTATGGTGGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.37958278	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617173	171617193	170760663	170760683	79902	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGCAGATCAGTAATAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.554033315	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617182	171617202	170760672	170760692	79903	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTAATAGCTTAGGAATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.409572385	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617186	171617206	170760676	170760696	79904	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAGCTTAGGAATGAGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.97515156	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617276	171617296	170760766	170760786	79905	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTTAGGCCAAAGAAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.315916579	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617279	171617299	170760769	170760789	79906	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTACCTTAGGCCAAAGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.363953985	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617282	171617302	170760772	170760792	79907	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTTTGGCCTAAGGTAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127296995	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617282	171617302	170760772	170760792	79908	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACCTTACCTTAGGCCAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.211007483	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617283	171617303	170760773	170760793	79909	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTTTGGCCTAAGGTAAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.756717401	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617292	171617312	170760782	170760802	79910	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGTAAGGTAGGGAATACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055809617	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617317	171617337	170760807	170760827	79911	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTAACTGTTCTGTCCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111158113	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617324	171617344	170760814	170760834	79912	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCTGTCCTAGAAGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.178988857	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617327	171617347	170760817	170760837	79913	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGTCCTAGAAGGAATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.82901926	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617344	171617364	170760834	170760854	79914	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGGAGGATGGTGGTCATTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054721059	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617370	171617390	170760860	170760880	79915	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAAAAGAGAGGTTAAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.341127254	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617398	171617418	170760888	170760908	79916	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGAGAGACGGACATGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135180659	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617404	171617424	170760894	170760914	79917	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGATATGAGAGACGGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.44539675	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617405	171617425	170760895	170760915	79918	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAGATATGAGAGACGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253176258	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617411	171617431	170760901	170760921	79919	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGGCTGCAGATATGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.752239209	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617458	171617478	170760948	170760968	79920	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCCAAAAAGAGATTCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.536628693	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617487	171617507	170760977	170760997	79921	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTAAGCCTCTATGTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140240233	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617512	171617532	170761002	170761022	79922	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGACTGATGAATCAAGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.171651257	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617559	171617579	170761049	170761069	79923	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAAAATGTTGAACTTAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.366781064	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617589	171617609	170761079	170761099	79924	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAACAAAGAGAATTGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.454055887	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617590	171617610	170761080	170761100	79925	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATAACAAAGAGAATTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.178041448	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617594	171617614	170761084	170761104	79926	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCCATAACAAAGAGAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.032142315	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617728	171617748	170761218	170761238	79927	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCGACTACTCTGGCTCTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101874393	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617735	171617755	170761225	170761245	79928	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTGGCTCTTGAATGGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.474169569	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617747	171617767	170761237	170761257	79929	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGGAGAATGGATTTGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.144852518	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617748	171617768	170761238	170761258	79930	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGAGAATGGATTTGATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.467478744	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617749	171617769	170761239	170761259	79931	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAGAATGGATTTGATAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.290755078	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617775	171617795	170761265	170761285	79932	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAGTGAATGAAGTGACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.007248979	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617802	171617822	170761292	170761312	79933	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTTGCAGTAATCCAAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.098599	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617803	171617823	170761293	170761313	79934	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTGCAGTAATCCAAGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057991227	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617817	171617837	170761307	170761327	79935	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCTACTAGCACCCTTTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165414619	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617817	171617837	170761307	170761327	79936	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTAAAGGGTGCTAGTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.525133388	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617827	171617847	170761317	170761337	79937	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTAGTAGCTTGGCCTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.6941604	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617836	171617856	170761326	170761346	79938	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTGGCCTAAAGTGGTAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198599388	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617856	171617876	170761346	170761366	79939	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGAAACAGAGAAAAGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.23729749	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617861	171617881	170761351	170761371	79940	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAGAGAAAAGTGCATGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261957085	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617895	171617915	170761385	170761405	79941	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATATAAAATTGACATGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.323970141	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617896	171617916	170761386	170761406	79942	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATATAAAATTGACATGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.524230724	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617907	171617927	170761397	170761417	79943	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACATGACTGGGTTATGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005639414	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617913	171617933	170761403	170761423	79944	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTGGGTTATGAATTGGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.547765535	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617963	171617983	170761453	170761473	79945	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCAGGCTTCTTACTTGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05714852	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617965	171617985	170761455	170761475	79946	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCACTGGCAAGTAAGAAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.217268798	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617966	171617986	170761456	170761476	79947	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCACTGGCAAGTAAGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085041715	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617982	171618002	170761472	170761492	79948	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGTTATAGTCACTAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.920558184	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617982	171618002	170761472	170761492	79949	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCTTAGTGACTATAACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.329475507	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617983	171618003	170761473	170761493	79950	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTGGTTATAGTCACTAAGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274736284	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171617994	171618014	170761484	170761504	79951	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTAAGATAGGGACTGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322147305	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618007	171618027	170761497	170761517	79952	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTGAAAGAGGACAAGATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.211095428	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618079	171618099	170761569	170761589	79953	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACATCCAAAAGAAGAAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.071863661	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618082	171618102	170761572	170761592	79954	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCAAAAGAAGAAGTCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177987012	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618110	171618130	170761600	170761620	79955	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTATGTGAATTCAGAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.289057426	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618131	171618151	170761621	170761641	79956	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGTCTGAGAAGACATGTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105565719	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618132	171618152	170761622	170761642	79957	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTGAGAAGACATGTATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1509842	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618165	171618185	170761655	170761675	79958	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGACAATGAGCCAAGCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009181005	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618178	171618198	170761668	170761688	79959	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGATTTCATCCATTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.193385968	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618203	171618223	170761693	170761713	79960	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAATGATTATGAATAAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.365115474	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618259	171618279	170761749	170761769	79961	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATTTGGCAAGAGGCATATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.052776653	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618268	171618288	170761758	170761778	79962	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTCATGCAAATTTGGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220479639	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618275	171618295	170761765	170761785	79963	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATTGCAGAGTCATGCAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.705360925	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618321	171618341	170761811	170761831	79964	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGAGTTTATTTCTCCACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.130208848	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618333	171618353	170761823	170761843	79965	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCCACCCCTGGATTCTGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036897168	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618337	171618357	170761827	170761847	79966	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCAGTTCAGAATCCAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.742260031	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618340	171618360	170761830	170761850	79967	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAAGGCCAGTTCAGAATCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091187859	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618341	171618361	170761831	170761851	79968	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAAGGCCAGTTCAGAATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.443912789	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618342	171618362	170761832	170761852	79969	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACAAGGCCAGTTCAGAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.36417188	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618379	171618399	170761869	170761889	79970	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAATATGGTGAAAGTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111508543	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618381	171618401	170761871	170761891	79971	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATATGGTGAAAGTGATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.503947279	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618382	171618402	170761872	170761892	79972	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATATGGTGAAAGTGATGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286239223	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618406	171618426	170761896	170761916	79973	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCTGAGCCTAGAAGTCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.896699361	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618411	171618431	170761901	170761921	79974	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGCCTAGAAGTCAAGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214693556	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618452	171618472	170761942	170761962	79975	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTCTTAACATGGTGGTCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037853532	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618461	171618481	170761951	170761971	79976	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATCTAGGCTTCTTAACATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012559935	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618474	171618494	170761964	170761984	79977	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTAGATTAACCCTTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102998702	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618477	171618497	170761967	170761987	79978	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCCTTCTCAAAGGGTTAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.497969884	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618495	171618515	170761985	170762005	79979	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GGTAAACGACAATGAGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092378075	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618552	171618572	170762042	170762062	79980	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGAATAAAGTCATAGATTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.157607836	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618553	171618573	170762043	170762063	79981	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATAAAGTCATAGATTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.244346039	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618554	171618574	170762044	170762064	79982	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAATAAAGTCATAGATTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.562863796	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618580	171618600	170762070	170762090	79983	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACTTGTCTGGTGGCTGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.555518623	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618582	171618602	170762072	170762092	79984	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACTTGTCTGGTGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.922348295	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618598	171618618	170762088	170762108	79985	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTACATGAGTGACCACACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.107584609	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618635	171618655	170762125	170762145	79986	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTGAGGTTGGCTTGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.566305049	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618636	171618656	170762126	170762146	79987	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GAGTTGAGGTTGGCTTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050607502	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618642	171618662	170762132	170762152	79988	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGCAAGTTGAGGTTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.761074771	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618647	171618667	170762137	170762157	79989	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GATGGGGTAGCAAGTTGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045142825	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171618651	171618671	170762141	170762161	79990	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTTCAATGGGGTAGCAAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.168928483	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619003	171619023	170762493	170762513	79991	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GTAGCCACTAAGTTTCAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245126362	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619009	171619029	170762499	170762519	79992	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCAACCAATCTTGAAACTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.474187811	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619042	171619062	170762532	170762552	79993	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GACCACTGATGCAGTAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.718191352	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619047	171619067	170762537	170762557	79994	hg19	N/A	N/A	N/A	Enhatls103717	enhancer	enh				GCTCCTCGGCTACTGCATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.373372381	ERICH2	chr2	170770377	170798977	7763				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619246	171619266	170762736	170762756	79995	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATGTGTCAAATATAGCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254492551	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619301	171619321	170762791	170762811	79996	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTTAATGACATGAAGGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.001917714	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619319	171619339	170762809	170762829	79997	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTGGTAACACAGTGACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.817179945	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619320	171619340	170762810	170762830	79998	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGGTAACACAGTGACAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.477582603	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619321	171619341	170762811	170762831	79999	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGGTAACACAGTGACAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107891757	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619327	171619347	170762817	170762837	80000	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACAGTGACAACTGGGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257259272	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619328	171619348	170762818	170762838	80001	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACAGTGACAACTGGGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000124439	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619351	171619371	170762841	170762861	80002	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAAACTTATAAGCTCAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328712726	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619377	171619397	170762867	170762887	80003	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAATAGAGTTTGAGATGTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371023922	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619422	171619442	170762912	170762932	80004	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCATATTATCTAACTACATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.608960337	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619440	171619460	170762930	170762950	80005	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTGACCTGAAGCTCAGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.500440871	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619441	171619461	170762931	170762951	80006	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGACCTGAAGCTCAGTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416421042	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619448	171619468	170762938	170762958	80007	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTGGCCCTAAACTGAGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.451211518	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619457	171619477	170762947	170762967	80008	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTTAGGGCCAGTCAGCATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.267521546	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619460	171619480	170762950	170762970	80009	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGGCCAGTCAGCATAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.64488734	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619467	171619487	170762957	170762977	80010	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCGACCACCTTTATGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.201223618	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619495	171619515	170762985	170763005	80011	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGTGATCTCGTTTACACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253335155	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619495	171619515	170762985	170763005	80012	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCAGTGTAAACGAGATCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201818334	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619496	171619516	170762986	170763006	80013	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAGTGTAAACGAGATCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.583219763	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619511	171619531	170763001	170763021	80014	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACCAGGGAGACCATGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.476764352	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619512	171619532	170763002	170763022	80015	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCAGGGAGACCATGTCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.459183259	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619515	171619535	170763005	170763025	80016	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGGAGACCATGTCGACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.457472515	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619516	171619536	170763006	170763026	80017	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGGAGACCATGTCGACGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.099255744	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619516	171619536	170763006	170763026	80018	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCCGTCGACATGGTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.080905575	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619519	171619539	170763009	170763029	80019	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGACCATGTCGACGGGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101276382	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619520	171619540	170763010	170763030	80020	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCATGTCGACGGGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.413442966	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619521	171619541	170763011	170763031	80021	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCATGTCGACGGGTGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.285190161	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619525	171619545	170763015	170763035	80022	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCCCCTCCCACCCGTCGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.393930663	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619540	171619560	170763030	170763050	80023	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGGGATCTTAGCGCACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.989717865	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619591	171619611	170763081	170763101	80024	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACACAAAGAAGCTCATGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070961696	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619599	171619619	170763089	170763109	80025	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAGCTCATGAAGAGGAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239839569	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619600	171619620	170763090	170763110	80026	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGCTCATGAAGAGGAGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.54758464	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619945	171619965	170763435	170763455	80027	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGCAAGACCCTGTTGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.395996515	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619946	171619966	170763436	170763456	80028	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGCAAGACCCTGTTGATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.089983225	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619956	171619976	170763446	170763466	80029	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCACTTACCCTGCATCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.095299688	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619957	171619977	170763447	170763467	80030	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTCACTTACCCTGCATCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093039376	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619965	171619985	170763455	170763475	80031	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGGTAAGTGAGTGCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.161702345	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619980	171620000	170763470	170763490	80032	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAAGTGGACCTTAGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086877071	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619981	171620001	170763471	170763491	80033	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAAGTGGACCTTAGCTCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.019227593	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619982	171620002	170763472	170763492	80034	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAGTGAGCTAAGGTCCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204419091	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619988	171620008	170763478	170763498	80035	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCTTAGCTCACTGGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.45354833	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171619992	171620012	170763482	170763502	80036	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCGAGAACCCAGTGAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086123171	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620027	171620047	170763517	170763537	80037	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTTAAGGGCAAGCCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078351214	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620097	171620117	170763587	170763607	80038	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCCTGCAAAGCAGGAGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048232719	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620101	171620121	170763591	170763611	80039	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCTAATGCTCCTGCTTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.27649334	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620171	171620191	170763661	170763681	80040	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTTGCATGCAGATTAAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.505616354	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620211	171620231	170763701	170763721	80041	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGGAAGGGGTAGTAACCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.115510831	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620212	171620232	170763702	170763722	80042	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGGAAGGGGTAGTAACCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.355601336	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620224	171620244	170763714	170763734	80043	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAACCATTGGGCCATTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.33026379	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620229	171620249	170763719	170763739	80044	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTGGGCCATTTCCACGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.595743735	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620230	171620250	170763720	170763740	80045	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTGGGCCATTTCCACGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.601970797	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620230	171620250	170763720	170763740	80046	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTTCCGTGGAAATGGCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.808375336	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620231	171620251	170763721	170763741	80047	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGGGCCATTTCCACGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.010261752	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620238	171620258	170763728	170763748	80048	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCACCCCTTTCCGTGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.298866598	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620256	171620276	170763746	170763766	80049	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAACTACCAAGTGTTGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.772404066	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620285	171620305	170763775	170763795	80050	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAAATTGACATGGCACACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.419540522	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620383	171620403	170763873	170763893	80051	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGACTCGACTCGAGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026677218	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620384	171620404	170763874	170763894	80052	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAGGACTCGACTCGAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.577735155	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620388	171620408	170763878	170763898	80053	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGCAGGACTCGACTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336158946	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620623	171620643	170764113	170764133	80054	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAATGCAGTGAACCCACTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.38361775	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620626	171620646	170764116	170764136	80055	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAGTGAACCCACTGCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.25341338	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620629	171620649	170764119	170764139	80056	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGAACCCACTGCAAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.188433176	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620637	171620657	170764127	170764147	80057	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAGCTCCGCCTCCTTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175858308	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620638	171620658	170764128	170764148	80058	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAGCTCCGCCTCCTTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.410623257	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620759	171620779	170764249	170764269	80059	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGCAGTAGAAAAATCTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091751372	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620773	171620793	170764263	170764283	80060	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTCCTAAGGCAAGAAGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.831040995	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620800	171620820	170764290	170764310	80061	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTCAGAGCGGTATGTGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.170674346	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620801	171620821	170764291	170764311	80062	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTCAGAGCGGTATGTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.626990868	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620802	171620822	170764292	170764312	80063	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTCAGAGCGGTATGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.591527262	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620813	171620833	170764303	170764323	80064	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAATAGTGTCAGATTCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.19824554	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620834	171620854	170764324	170764344	80065	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCAGAGCAGTTTCAGCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.067195862	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620837	171620857	170764327	170764347	80066	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCGCACTGCTGAAACTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.031285022	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620850	171620870	170764340	170764360	80067	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGTGCGGTGTAAAGCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19642416	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620851	171620871	170764341	170764361	80068	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGCGGTGTAAAGCCAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.163473975	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620867	171620887	170764357	170764377	80069	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTGCTCAGCTTGCCCTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01442034	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620883	171620903	170764373	170764393	80070	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAATGATGAAAATTAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.199340296	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620907	171620927	170764397	170764417	80071	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGCCCACATGTAGAGACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.223167357	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620912	171620932	170764402	170764422	80072	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACCAAGAGTCTCTACATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.220972146	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620913	171620933	170764403	170764423	80073	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACCAAGAGTCTCTACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.407294663	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620915	171620935	170764405	170764425	80074	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTAGAGACTCTTGGTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175487073	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620919	171620939	170764409	170764429	80075	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGACTCTTGGTGCTCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.152162334	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620920	171620940	170764410	170764430	80076	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGACTCTTGGTGCTCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214706176	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620928	171620948	170764418	170764438	80077	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGTGCTCAGGACGGGAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150031477	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171620929	171620949	170764419	170764439	80078	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGCTCAGGACGGGAAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.317860272	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621022	171621042	170764512	170764532	80079	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTCAGGGGAAACACCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.489443129	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621039	171621059	170764529	170764549	80080	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTGGAAAAACATTCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08516191	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621040	171621060	170764530	170764550	80081	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTTGGAAAAACATTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.6135214	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621041	171621061	170764531	170764551	80082	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATGTTGGAAAAACATTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.283439268	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621057	171621077	170764547	170764567	80083	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAGCTGGGGAAAGCAAATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.919916588	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621090	171621110	170764580	170764600	80084	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAAACTAAACACAAGTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.135326338	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621091	171621111	170764581	170764601	80085	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAAAACTAAACACAAGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024615414	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621123	171621143	170764613	170764633	80086	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAATTATATATTGACATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.840133959	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621135	171621155	170764625	170764645	80087	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTATAATTGGGTACAATTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119201854	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621155	171621175	170764645	170764665	80088	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATCTAAAAGCAAATAAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.187857602	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621156	171621176	170764646	170764666	80089	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAATCTAAAAGCAAATAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.757441546	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621180	171621200	170764670	170764690	80090	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTCTCAATTGAGTGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248720029	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621181	171621201	170764671	170764691	80091	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATTCTCAATTGAGTGGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265459126	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621182	171621202	170764672	170764692	80092	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTCTCAATTGAGTGGGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.013580548	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621213	171621233	170764703	170764723	80093	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGAAGATAGCTGTGAGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055589581	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621225	171621245	170764715	170764735	80094	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTATCTTCAAGTCACAGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.035042373	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621434	171621454	170764924	170764944	80095	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAACAAACTAATTTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245924709	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621435	171621455	170764925	170764945	80096	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAACAAACTAATTTCCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077512453	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621436	171621456	170764926	170764946	80097	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAACAAACTAATTTCCTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.214762292	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621452	171621472	170764942	170764962	80098	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAAAAAGCATTGCCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.349554117	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621455	171621475	170764945	170764965	80099	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGAGAAAAAAGCATTGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.188627677	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621494	171621514	170764984	170765004	80100	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGATAAGGGAAAATTCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.572803114	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621507	171621527	170764997	170765017	80101	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTTCCTAAACTGGTGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.502755222	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621508	171621528	170764998	170765018	80102	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGTTTCCTAAACTGGTGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.144212988	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621516	171621536	170765006	170765026	80103	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTACAGCAGGGTTTCCTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207013919	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621529	171621549	170765019	170765039	80104	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGAATCAATCGGCTACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.843665288	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621530	171621550	170765020	170765040	80105	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAGAATCAATCGGCTACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229278146	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621534	171621554	170765024	170765044	80106	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAGCCGATTGATTCTACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.523819825	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621540	171621560	170765030	170765050	80107	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAATCCGTAGGTAGAATCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.539620321	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621553	171621573	170765043	170765063	80108	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAAAACCCAAAAGGAATCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.972700002	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621563	171621583	170765053	170765073	80109	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCTCTATTGTAAAACCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.205807129	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621595	171621615	170765085	170765105	80110	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCCTAAATCTAGAGATAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.549739325	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621610	171621630	170765100	170765120	80111	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAGGGATTCCTGTTACCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.069569316	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621616	171621636	170765106	170765126	80112	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTCCTGTTACCTCAGGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.674011064	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621621	171621641	170765111	170765131	80113	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTCCAAGTCCCTGAGGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.676087838	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621628	171621648	170765118	170765138	80114	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGGAGGGCTCCAAGTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238674239	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621644	171621664	170765134	170765154	80115	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTACTGTAAATAGTCTAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.064426407	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621645	171621665	170765135	170765155	80116	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTACTGTAAATAGTCTAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.072763781	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621649	171621669	170765139	170765159	80117	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGACTATTTACAGTAAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.177482003	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621677	171621697	170765167	170765187	80118	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATACCACCAGTTATTACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.359397672	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621683	171621703	170765173	170765193	80119	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTCCTAAGGTAATAACTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.33720268	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621686	171621706	170765176	170765196	80120	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGAGTTCCTAAGGTAATAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.774988482	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621696	171621716	170765186	170765206	80121	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTTACAAAGGAGTTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.461895932	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621697	171621717	170765187	170765207	80122	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGGAACTCCTTTGTAACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.563272195	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621698	171621718	170765188	170765208	80123	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GGAACTCCTTTGTAACACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.326095074	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621705	171621725	170765195	170765215	80124	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTTTGTAACACCAGGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.583980593	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621706	171621726	170765196	170765216	80125	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTTGTAACACCAGGGTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.024288852	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621707	171621727	170765197	170765217	80126	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACTGACCCTGGTGTTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.156021923	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621718	171621738	170765208	170765228	80127	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGTTAAGTACCCACTGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171425359	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621725	171621745	170765215	170765235	80128	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGGGTACTTAACAAAATATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.437916438	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621732	171621752	170765222	170765242	80129	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTAACAAAATATTGGGCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.362166153	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621747	171621767	170765237	170765257	80130	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTAAGGGCAAAGATGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.557720371	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621778	171621798	170765268	170765288	80131	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAGAGACATCTTTAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054558975	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621779	171621799	170765269	170765289	80132	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAGAGACATCTTTAACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198644788	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621805	171621825	170765295	170765315	80133	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAAATTCCCAGTCCGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.651782117	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621815	171621835	170765305	170765325	80134	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAACAATCCTTTCACGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.673624681	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621816	171621836	170765306	170765326	80135	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTAACAATCCTTTCACGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.062161581	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621821	171621841	170765311	170765331	80136	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATAACTTAACAATCCTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156558512	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621845	171621865	170765335	170765355	80137	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCACTTTCCTAGGATATGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.377504743	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621852	171621872	170765342	170765362	80138	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTAGGATATGAGTTGGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.823284243	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621854	171621874	170765344	170765364	80139	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTGTCACCAACTCATATCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124588112	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621878	171621898	170765368	170765388	80140	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAAGTGCCTCCTTATATGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.210615319	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621880	171621900	170765370	170765390	80141	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAGACATATAAGGAGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1315125	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621887	171621907	170765377	170765397	80142	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCTTCCTCCAGACATATAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.688901733	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621890	171621910	170765380	170765400	80143	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGGCTTCCTCCAGACATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002497604	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621924	171621944	170765414	170765434	80144	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATGACTGTAAGATACAAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.20984108	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621925	171621945	170765415	170765435	80145	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGACTGTAAGATACAAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.109640185	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621930	171621950	170765420	170765440	80146	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAAGATACAAAATTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.256312282	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621984	171622004	170765474	170765494	80147	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAATCATGATATTAATGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.432392054	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621994	171622014	170765484	170765504	80148	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTAATGCCCATGGAAATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.415292401	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171621995	171622015	170765485	170765505	80149	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTAATGCCCATGGAAATGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11285978	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622010	171622030	170765500	170765520	80150	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTGAAAGGGCGATCAACACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.464211474	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622020	171622040	170765510	170765530	80151	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GATCAACACTATGGTTTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061867218	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622021	171622041	170765511	170765531	80152	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTCAACACTATGGTTTGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.398761316	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622022	171622042	170765512	170765532	80153	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCAACACTATGGTTTGAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.263068769	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622023	171622043	170765513	170765533	80154	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAACACTATGGTTTGAAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.433489857	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622053	171622073	170765543	170765563	80155	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGAGCACAGATGTGTTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111988955	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622111	171622131	170765601	170765621	80156	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAGAACAATGAAATTCTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050048131	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622134	171622154	170765624	170765644	80157	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCCCAGTGTGAGCCCAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.567423839	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622137	171622157	170765627	170765647	80158	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GCCTCATCTGGGCTCACACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.219837317	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622138	171622158	170765628	170765648	80159	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GACCTCATCTGGGCTCACACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.016457339	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622139	171622159	170765629	170765649	80160	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GAACCTCATCTGGGCTCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.220537052	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622149	171622169	170765639	170765659	80161	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTGGCAGCTGAACCTCATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171354308	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622150	171622170	170765640	170765660	80162	hg19	N/A	enh70020	N/A	Enhatls103717	enhancer	enh				GTTGGCAGCTGAACCTCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.33853071	ERICH2	chr2	170770377	170798977	4698				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622269	171622289	170765759	170765779	80163	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCAGTAGTGACTCAATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.395469063	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622510	171622530	170766000	170766020	80164	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGTCGGGTTGGGCATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.267601283	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622518	171622538	170766008	170766028	80165	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAAAAAGGTTGGTCGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075976818	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622519	171622539	170766009	170766029	80166	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTAAAAAAGGTTGGTCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127650179	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622587	171622607	170766077	170766097	80167	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTTATCCACACATCAAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.168073709	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622590	171622610	170766080	170766100	80168	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATCCACACATCAAGAATTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.266444365	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622632	171622652	170766122	170766142	80169	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCCTACAATAACACTGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041865364	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622637	171622657	170766127	170766147	80170	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCCAAAACAGTGTTATTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029328837	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622660	171622680	170766150	170766170	80171	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAAGACAGTAGAGGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101821197	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622667	171622687	170766157	170766177	80172	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTATTTCAAAGACAGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197302421	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622668	171622688	170766158	170766178	80173	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTATTATTTCAAAGACAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.34176421	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622709	171622729	170766199	170766219	80174	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTATTAGAATCTAGTCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.413422619	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622710	171622730	170766200	170766220	80175	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTATTAGAATCTAGTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.164091862	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622713	171622733	170766203	170766223	80176	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAAGTATTAGAATCTAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.255206366	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622748	171622768	170766238	170766258	80177	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACAATCTCATGCAGTAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121106529	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622887	171622907	170766377	170766397	80178	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTACCATTCGTGGATAAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.701206896	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622895	171622915	170766385	170766405	80179	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCACGAATGGTAATTTCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.394480113	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622898	171622918	170766388	170766408	80180	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCATATGAAATTACCATTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.165451926	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171622939	171622959	170766429	170766449	80181	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTAATTGTCAAAGAATAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.826830915	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623053	171623073	170766543	170766563	80182	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTAAATTCCCTAAATGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135748609	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623064	171623084	170766554	170766574	80183	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAATTAACCAATGCATTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.82914644	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623065	171623085	170766555	170766575	80184	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAAATTAACCAATGCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.205405271	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623093	171623113	170766583	170766603	80185	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTTGACAAATATTAACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091422019	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623130	171623150	170766620	170766640	80186	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACATATATTCCTATAAGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139716454	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623250	171623270	170766740	170766760	80187	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAAGCCACATGCTTACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.394119395	ERICH2	chr2	170770377	170798977	3634				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623250	171623270	170766740	170766760	80188	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GCAAAGCCACATGCTTACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.394119395	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623258	171623278	170766748	170766768	80189	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GCATGCTTACAAGAGGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126051257	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623299	171623319	170766789	170766809	80190	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GTTTAACTGAGAGAAGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.037869549	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623300	171623320	170766790	170766810	80191	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GTTAACTGAGAGAAGGAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124100558	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623356	171623376	170766846	170766866	80192	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GTTGAGAAAACCAGCAAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.512041861	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623361	171623381	170766851	170766871	80193	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GAAAACCAGCAAATCCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.685030085	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623369	171623389	170766859	170766879	80194	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GCAAATCCTGGAAAGGATTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204562363	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623404	171623424	170766894	170766914	80195	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GTCAATACACTTCAAATACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124420442	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623404	171623424	170766894	170766914	80196	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCAATACACTTCAAATACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.124420442	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623405	171623425	170766895	170766915	80197	hg19	N/A	enh70020	fant9230	N/A	enhancer	enh				GCAATACACTTCAAATACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061623855	ERICH2	chr2	170770377	170798977	3481				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623405	171623425	170766895	170766915	80198	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAATACACTTCAAATACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061623855	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623424	171623444	170766914	170766934	80199	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAGTTACTGTGAAGTACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158841803	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623425	171623445	170766915	170766935	80200	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTAGTTACTGTGAAGTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.031078015	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623440	171623460	170766930	170766950	80201	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTAACAAGAAAGCATCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140254867	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623441	171623461	170766931	170766951	80202	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTAACAAGAAAGCATCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.460661488	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623566	171623586	170767056	170767076	80203	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGCATTCTTCGAGCTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167402755	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623695	171623715	170767185	170767205	80204	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACCAATTAAATCTTATGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.169410665	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623700	171623720	170767190	170767210	80205	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCCAGACATAAGATTTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.146883131	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171623707	171623727	170767197	170767217	80206	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTATGTCTGGCATAATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.042117634	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624042	171624062	170767532	170767552	80207	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTATTTGTTGAGGGCCGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.643820112	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624090	171624110	170767580	170767600	80208	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTTGAAAAATTTCAAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.094582437	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624175	171624195	170767665	170767685	80209	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACATTTGGGAAATGTTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.517306466	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624200	171624220	170767690	170767710	80210	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGTTAAGCAAAAAGGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.481812036	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624276	171624296	170767766	170767786	80211	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATATATATGTGAGCACAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.079504444	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624284	171624304	170767774	170767794	80212	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGAGCACAAAGAGGATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373592747	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624307	171624327	170767797	170767817	80213	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAAAATAGAATTATTGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.079735145	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624321	171624341	170767811	170767831	80214	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGACTGAGGTTATTACTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.363544249	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624332	171624352	170767822	170767842	80215	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTACTGAGTGGTAGAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254355292	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624336	171624356	170767826	170767846	80216	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGAGTGGTAGAATTCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.260467901	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624472	171624492	170767962	170767982	80217	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATGAGTCCATTAAAAATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.172708734	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624701	171624721	170768191	170768211	80218	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGCAGTGAGCTGAGAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.799064293	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624847	171624867	170768337	170768357	80219	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCGTTCTAACAAAGTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.407841293	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624852	171624872	170768342	170768362	80220	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGAGTTCGTTCTAACAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.845309816	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624868	171624888	170768358	170768378	80221	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTTGCTAGACAGACACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.933283363	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624897	171624917	170768387	170768407	80222	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTCAGTGGTGTAAATGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.544341712	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624902	171624922	170768392	170768412	80223	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGTGTAAATGCACAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.48259391	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624903	171624923	170768393	170768413	80224	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGTGTAAATGCACAGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083464106	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624923	171624943	170768413	170768433	80225	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATAAAGCACAGTTTAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.109753793	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171624962	171624982	170768452	170768472	80226	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAACTTCTGCAGAAAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141468633	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625042	171625062	170768532	170768552	80227	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGAAGCAAAATAATCATCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.589047076	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625052	171625072	170768542	170768562	80228	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAATCATCAGTGGTTCAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.434862021	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625058	171625078	170768548	170768568	80229	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCAGTGGTTCAAATAGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.059435227	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625064	171625084	170768554	170768574	80230	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCAAATAGGTACTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.383783203	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625085	171625105	170768575	170768595	80231	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGATCATTAGGTAAAGTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.893947448	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625097	171625117	170768587	170768607	80232	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTAAGAATTAAAGATCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078554535	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625182	171625202	170768672	170768692	80233	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGACGAATTGTCATGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040128192	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625195	171625215	170768685	170768705	80234	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGTGCGAGGCTCTGTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087102209	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625196	171625216	170768686	170768706	80235	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGTGCGAGGCTCTGTGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.407924168	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625232	171625252	170768722	170768742	80236	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCATTCCATGTTCTGAGCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.064167519	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625233	171625253	170768723	170768743	80237	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTCCATGTTCTGAGCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140514908	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625234	171625254	170768724	170768744	80238	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCCATGTTCTGAGCTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.065457707	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625238	171625258	170768728	170768748	80239	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGTTCTGAGCTACAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.26031248	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625239	171625259	170768729	170768749	80240	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCCCCTGTAGCTCAGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006016569	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625278	171625298	170768768	170768788	80241	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTGGCACTTGAAGACCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057650536	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625278	171625298	170768768	170768788	80242	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAGGTCTTCAAGTGCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.267963826	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625285	171625305	170768775	170768795	80243	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTGAAGACCTTGAGGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.01421958	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625288	171625308	170768778	170768798	80244	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGACCTTGAGGCCCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021452243	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625296	171625316	170768786	170768806	80245	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGCTTCCACCTTGGGCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.418959564	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625304	171625324	170768794	170768814	80246	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTGATCTGGCTTCCACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.445638699	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625305	171625325	170768795	170768815	80247	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTGATCTGGCTTCCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.202019931	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625317	171625337	170768807	170768827	80248	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGAGTGGTTAGAGTGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.071617796	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625321	171625341	170768811	170768831	80249	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTCTAACCACTCCTCGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077382942	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625331	171625351	170768821	170768841	80250	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGTTCTCCACATCGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073966072	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625336	171625356	170768826	170768846	80251	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAAGTATGTTCTCCACATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24550237	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625473	171625493	170768963	170768983	80252	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCATAGTGGCACGGGTGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.174732307	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625474	171625494	170768964	170768984	80253	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCATAGTGGCACGGGTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.010300047	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625940	171625960	170769430	170769450	80254	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGAGCAAAAATGGATTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029130408	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625941	171625961	170769431	170769451	80255	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGAGCAAAAATGGATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.850275703	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625949	171625969	170769439	170769459	80256	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCCTGAAGGGAGCAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.352711932	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171625995	171626015	170769485	170769505	80257	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAAAGCTCAAGTTCATTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.003335521	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626012	171626032	170769502	170769522	80258	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTTCTGTCAGGGGGAAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334094105	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626042	171626062	170769532	170769552	80259	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGAAAGTTTAATCAAATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081163473	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626074	171626094	170769564	170769584	80260	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTTCCTTGTAGTGGATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.227868758	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626081	171626101	170769571	170769591	80261	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTCCCATTGATCCACTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.074579068	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626106	171626126	170769596	170769616	80262	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGAATGGATAATGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.01826608	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626114	171626134	170769604	170769624	80263	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAGTACTGATGAATGGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.453623474	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626185	171626205	170769675	170769695	80264	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTTCATTTAAACAAGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.635533743	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626235	171626255	170769725	170769745	80265	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAGGGTGTTCCTGTAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068229526	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626238	171626258	170769728	170769748	80266	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGTGTTCCTGTAATAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.672071565	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626244	171626264	170769734	170769754	80267	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCTGTAATAGAGGAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.242615782	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626248	171626268	170769738	170769758	80268	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCACTGCCTCCTCTATTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009490678	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626270	171626290	170769760	170769780	80269	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTATGTCCTTATCAAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.086545901	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626270	171626290	170769760	170769780	80270	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAGTTTGATAAGGACATAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.042204894	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626280	171626300	170769770	170769790	80271	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATACATCCCTAGTTTGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083429357	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626338	171626358	170769828	170769848	80272	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAAGGAAAAATGCCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.091761314	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626354	171626374	170769844	170769864	80273	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGATGATAGGTAGGAGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.272562379	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626354	171626374	170769844	170769864	80274	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGCCTCCTACCTATCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.314721069	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626355	171626375	170769845	170769865	80275	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCCTCCTACCTATCATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.374354513	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626360	171626380	170769850	170769870	80276	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCCCTTGATGATAGGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.117784829	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626363	171626383	170769853	170769873	80277	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGAGCCCTTGATGATAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.256347738	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626363	171626383	170769853	170769873	80278	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCTATCATCAAGGGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.371293965	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626367	171626387	170769857	170769877	80279	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCTGTGAGCCCTTGATGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.86655522	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626438	171626458	170769928	170769948	80280	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCAAGAGAATACAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.344976291	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626455	171626475	170769945	170769965	80281	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGTTCCGGAAATGGTCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.401813798	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626462	171626482	170769952	170769972	80282	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGAACCAGCTGGACCATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.626037945	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626531	171626551	170770021	170770041	80283	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGTATAAAGCTCTGACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.280018084	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626565	171626585	170770055	170770075	80284	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCTTCACAACCATCTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.011477867	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626578	171626598	170770068	170770088	80285	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGATATGTACCTTGGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239302191	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626578	171626598	170770068	170770088	80286	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAGGATATGTACCTTGGTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239302191	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626581	171626601	170770071	170770091	80287	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCAAGGTACATATCCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.312074239	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626581	171626601	170770071	170770091	80288	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GACCAAGGTACATATCCTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.312074239	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626582	171626602	170770072	170770092	80289	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCAAGGTACATATCCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.560304944	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626582	171626602	170770072	170770092	80290	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCCAAGGTACATATCCTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.560304944	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626585	171626605	170770075	170770095	80291	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCGCTGAGGATATGTACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.011478005	ERICH2	chr2	170770377	170798977	292				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626585	171626605	170770075	170770095	80292	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCCCGCTGAGGATATGTACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.011478005	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626598	171626618	170770088	170770108	80293	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTCTGGAGTTGCTACCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.72781564	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626606	171626626	170770096	170770116	80294	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAGCAACTCCAGAGATTAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046410963	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626607	171626627	170770097	170770117	80295	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCAACTCCAGAGATTAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.171145975	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626639	171626659	170770129	170770149	80296	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCATGGTAGACACATAATATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.30729157	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626657	171626677	170770147	170770167	80297	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GATCTGGATTCGACTTTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202731483	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626735	171626755	170770225	170770245	80298	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTTACTTCCGGCATCCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004181831	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626771	171626791	170770261	170770281	80299	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTTGGCTTCTAGGAAGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.457456486	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626775	171626795	170770265	170770285	80300	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTTCCTAGAAGCCAAGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081839728	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626776	171626796	170770266	170770286	80301	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTTCCTAGAAGCCAAGCTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.358389379	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626777	171626797	170770267	170770287	80302	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTCAAGCTTGGCTTCTAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.207531944	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626781	171626801	170770271	170770291	80303	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTCCCTCAAGCTTGGCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140679959	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626789	171626809	170770279	170770299	80304	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTTCTAAAGGTCCCTCAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.147254468	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626831	171626851	170770321	170770341	80305	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTTGGGTCACAGTAGGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.374760633	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626832	171626852	170770322	170770342	80306	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTTGGGTCACAGTAGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142206295	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626835	171626855	170770325	170770345	80307	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GACTGCTTGGGTCACAGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.396769797	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626836	171626856	170770326	170770346	80308	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAACTGCTTGGGTCACAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216728901	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626837	171626857	170770327	170770347	80309	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTAACTGCTTGGGTCACAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.238120687	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626838	171626858	170770328	170770348	80310	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTAACTGCTTGGGTCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.513750759	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626859	171626879	170770349	170770369	80311	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTAAACACTAATACCTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.275748911	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626863	171626883	170770353	170770373	80312	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCACTAATACCTCCCATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.222207389	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626868	171626888	170770358	170770378	80313	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GATACCTCCCATTGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.101849436	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626874	171626894	170770364	170770384	80314	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTGCCACGCCGGCCAATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153113594	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626877	171626897	170770367	170770387	80315	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTCTGCCACGCCGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.185262586	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626878	171626898	170770368	170770388	80316	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTGCTCTGCCACGCCGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.42640306	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626885	171626905	170770375	170770395	80317	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAGCTGCTGCTCTGCCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.599040968	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626885	171626905	170770375	170770395	80318	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCGTGGCAGAGCAGCAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151349728	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626894	171626914	170770384	170770404	80319	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAGCAGCAGCTCTGGCGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.256108434	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626895	171626915	170770385	170770405	80320	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCAGCAGCTCTGGCGCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.847009044	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626902	171626922	170770392	170770412	80321	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTCTGGCGCTAGAGGGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.439782881	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626903	171626923	170770393	170770413	80322	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTCTGGCGCTAGAGGGAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.441870326	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626916	171626936	170770406	170770426	80323	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GGAACCTGGGCTGCTCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.40913547	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626917	171626937	170770407	170770427	80324	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAACCTGGGCTGCTCTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.389719178	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626918	171626938	170770408	170770428	80325	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAACCTGGGCTGCTCTAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.554072446	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626919	171626939	170770409	170770429	80326	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GACCTGGGCTGCTCTAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0433552	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626923	171626943	170770413	170770433	80327	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTCCCCCAGCTAGAGCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.381614605	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626927	171626947	170770417	170770437	80328	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GTGCTCTAGCTGGGGGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.556467877	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626928	171626948	170770418	170770438	80329	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GCTCTAGCTGGGGGAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.302795344	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626949	171626969	170770439	170770459	80330	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAGTGATTAGAACCAGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.247828682	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626949	171626969	170770439	170770459	80331	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTGATTAGAACCAGAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.247828682	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626962	171626982	170770452	170770472	80332	hg19	N/A	enh70020	fant9231	N/A	enhancer	enh				GAATCACTTGAATCTGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037191805	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626962	171626982	170770452	170770472	80333	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATCACTTGAATCTGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037191805	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626971	171626991	170770461	170770481	80334	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATCTGACTTCTGGGAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.837360572	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626979	171626999	170770469	170770489	80335	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCTGGGAAAACTGGCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012686419	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626980	171627000	170770470	170770490	80336	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTGGGAAAACTGGCGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.703060591	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171626991	171627011	170770481	170770501	80337	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGCGTCCAGGGACTCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.113587293	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627000	171627020	170770490	170770510	80338	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGTCTCCGGGGGGAGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.675850443	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627009	171627029	170770499	170770519	80339	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGATTATGGGTCTCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.115159169	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627010	171627030	170770500	170770520	80340	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGAAGATTATGGGTCTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26663872	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627010	171627030	170770500	170770520	80341	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGGAGACCCATAATCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.447333511	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627011	171627031	170770501	170770521	80342	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGAGACCCATAATCTTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.822245296	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627011	171627031	170770501	170770521	80343	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGAAGATTATGGGTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.132799506	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627012	171627032	170770502	170770522	80344	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAGACCCATAATCTTCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121175211	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627012	171627032	170770502	170770522	80345	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAGAAGATTATGGGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.341224885	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627013	171627033	170770503	170770523	80346	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCAAGAAGATTATGGGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.200817778	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627020	171627040	170770510	170770530	80347	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGTCGCCCCAAGAAGATTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06886559	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627021	171627041	170770511	170770531	80348	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGTCGCCCCAAGAAGATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.445132279	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627022	171627042	170770512	170770532	80349	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATCTTCTTGGGGCGACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.138442984	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627026	171627046	170770516	170770536	80350	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCTTGGGGCGACCTCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248299066	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627027	171627047	170770517	170770537	80351	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTTGGGGCGACCTCAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173601649	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627028	171627048	170770518	170770538	80352	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTGGGGCGACCTCAGGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.110077456	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627029	171627049	170770519	170770539	80353	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGGGCGACCTCAGGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.209775081	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627041	171627061	170770531	170770551	80354	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGACTTAGTCCCCCAACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050235039	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627044	171627064	170770534	170770554	80355	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGGGGACTAAGTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.147110917	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627045	171627065	170770535	170770555	80356	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGGGGACTAAGTCCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.522839193	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627046	171627066	170770536	170770556	80357	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGGGGACTAAGTCCTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.664776337	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627062	171627082	170770552	170770572	80358	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGAACAAGTGTCCCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.030834852	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627069	171627089	170770559	170770579	80359	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACACTTGTTCATCCACTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.23161545	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627070	171627090	170770560	170770580	80360	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACTTGTTCATCCACTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.314544602	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627084	171627104	170770574	170770594	80361	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGATGGGTGTCCCTGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046367996	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627090	171627110	170770580	170770600	80362	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGGAGAGATGGGTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.237048743	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627099	171627119	170770589	170770609	80363	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTCTTGAGTTGGGAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.513096592	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627100	171627120	170770590	170770610	80364	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGTCTTGAGTTGGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104065167	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627108	171627128	170770598	170770618	80365	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAAAAGAAGTCTTGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.440033752	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627109	171627129	170770599	170770619	80366	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTAAAAAGAAGTCTTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274814874	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627128	171627148	170770618	170770638	80367	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCCCAAGTTTAAAACTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.026574388	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627164	171627184	170770654	170770674	80368	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTAAGCGAGGGAGAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.653992012	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627167	171627187	170770657	170770677	80369	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCTCCCTCGCTTAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.309558923	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627169	171627189	170770659	170770679	80370	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGATTCTAAGCGAGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.193955648	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627170	171627190	170770660	170770680	80371	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTGATTCTAAGCGAGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.134967647	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627172	171627192	170770662	170770682	80372	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCTCGCTTAGAATCAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.454846894	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627175	171627195	170770665	170770685	80373	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCATACCTGATTCTAAGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048963185	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627176	171627196	170770666	170770686	80374	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCATACCTGATTCTAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.448608145	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627213	171627233	170770703	170770723	80375	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCGCCGAAGAAGGAAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150966646	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627217	171627237	170770707	170770727	80376	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCTTCTTCGGCGCTCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.128403561	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627221	171627241	170770711	170770731	80377	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCTTCAGGAGCGCCGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167851409	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627224	171627244	170770714	170770734	80378	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCGGCGCTCCTGAAGGTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.011254327	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627235	171627255	170770725	170770745	80379	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACGCGCACCGGTTACCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141395407	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627246	171627266	170770736	170770756	80380	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTGACGTGCGCACGCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.162793033	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627249	171627269	170770739	170770759	80381	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGTGCGCACGTCAATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.284561741	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627250	171627270	170770740	170770760	80382	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTGCGCACGTCAATCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.22168562	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627269	171627289	170770759	170770779	80383	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAACTGGGCGCACACACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014319126	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627270	171627290	170770760	170770780	80384	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGTGTGTGCGCCCAGTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.951640458	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627278	171627298	170770768	170770788	80385	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCCCAGTTTCCGGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.386319202	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627279	171627299	170770769	170770789	80386	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCCCAGTTTCCGGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.335883176	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627284	171627304	170770774	170770794	80387	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCCGCGGCGCCGGAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.107278504	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627285	171627305	170770775	170770795	80388	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGTCCCGCGGCGCCGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037920529	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627292	171627312	170770782	170770802	80389	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGTGGGTGTCCCGCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.601202523	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627295	171627315	170770785	170770805	80390	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGCGGGACACCCACAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.064759195	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627296	171627316	170770786	170770806	80391	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGGGACACCCACAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023006779	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627297	171627317	170770787	170770807	80392	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGGACACCCACAACCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.096883155	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627298	171627318	170770788	170770808	80393	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGCGGTTGTGGGTGTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.442599792	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627308	171627328	170770798	170770818	80394	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGACAGCCCCGCGGTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.398765771	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627309	171627329	170770799	170770819	80395	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGACAGCCCCGCGGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09160353	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627313	171627333	170770803	170770823	80396	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGGGGCTGTCCCTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24005357	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627315	171627335	170770805	170770825	80397	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGAGCTGAGGGACAGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.729242017	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627412	171627432	170770902	170770922	80398	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGCGCCCTCCACCGCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196250952	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627417	171627437	170770907	170770927	80399	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCTCCACCGCCCTACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.610668024	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627418	171627438	170770908	170770928	80400	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCCACCGCCCTACGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075719646	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627430	171627450	170770920	170770940	80401	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAGGCGGGCCCAGGCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02812098	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627444	171627464	170770934	170770954	80402	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCCACCCTGCCTCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.376120317	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627452	171627472	170770942	170770962	80403	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTGCCTCTCCGTGGTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.100264874	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627453	171627473	170770943	170770963	80404	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGCCTCTCCGTGGTTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073060912	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627454	171627474	170770944	170770964	80405	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGGGAACCACGGAGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.57085412	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627455	171627475	170770945	170770965	80406	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGGGGAACCACGGAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202222182	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627459	171627479	170770949	170770969	80407	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGCCCGGGGAACCACGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.390733795	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627464	171627484	170770954	170770974	80408	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGGCAGCCCGGGGAACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.014628789	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627540	171627560	170771030	170771050	80409	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCGGGCAGCAGCCGAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236693378	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627541	171627561	170771031	170771051	80410	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCGGGCAGCAGCCGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.606352307	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627544	171627564	170771034	170771054	80411	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGCTCGGGCAGCAGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.441538709	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627545	171627565	170771035	170771055	80412	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAAGCTCGGGCAGCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.281064988	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627557	171627577	170771047	170771067	80413	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACGGCGCGTGGAGGAAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152857804	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627558	171627578	170771048	170771068	80414	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACGGCGCGTGGAGGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.521651321	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627566	171627586	170771056	170771076	80415	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAGACTGCACGGCGCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.143726843	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627567	171627587	170771057	170771077	80416	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACGCGCCGTGCAGTCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416668023	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627569	171627589	170771059	170771079	80417	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTGGAGACTGCACGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.345302407	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627576	171627596	170771066	170771086	80418	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTCGCCGTGGAGACTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.00320177	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627587	171627607	170771077	170771097	80419	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCGGGAACGCAGCGTCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.502095578	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627589	171627609	170771079	170771099	80420	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGACGCTGCGTTCCCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13811332	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627605	171627625	170771095	170771115	80421	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAGCTGGGGGCTCCGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142042938	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627617	171627637	170771107	170771127	80422	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCTGCTCGCGCGGAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.390365709	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627618	171627638	170771108	170771128	80423	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAGCTGCTCGCGCGGAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.049685123	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627619	171627639	170771109	170771129	80424	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTAGCTGCTCGCGCGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076920872	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627620	171627640	170771110	170771130	80425	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCCGCGCGAGCAGCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.659448323	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627620	171627640	170771110	170771130	80426	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTAGCTGCTCGCGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.124731137	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627621	171627641	170771111	170771131	80427	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCCGCGCGAGCAGCTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.35930974	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627625	171627645	170771115	170771135	80428	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGAGCAGCTAGCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.213291022	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627626	171627646	170771116	170771136	80429	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCCCGGCTAGCTGCTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.230249048	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627632	171627652	170771122	170771142	80430	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGCTAGCCGGGCTGGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103033891	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627642	171627662	170771132	170771152	80431	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACACACCGAGAGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.159474976	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627646	171627666	170771136	170771156	80432	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGCTCTCGGTGTGTGCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.112644669	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627650	171627670	170771140	170771160	80433	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCGGTGTGTGCCCTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020401193	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627663	171627683	170771153	170771173	80434	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTCGGATGGTCTGCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.291816289	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627664	171627684	170771154	170771174	80435	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTTCAGCAGACCATCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.139151718	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627664	171627684	170771154	170771174	80436	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCGGATGGTCTGCTGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.722943896	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627665	171627685	170771155	170771175	80437	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCTTCAGCAGACCATCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091052642	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627675	171627695	170771165	170771185	80438	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCTGAAGAGGGCCGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.948971648	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627690	171627710	170771180	170771200	80439	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCAGCTGGTAAGACACTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225006885	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627690	171627710	170771180	170771200	80440	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGAGTGTCTTACCAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.444917349	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627693	171627713	170771183	170771203	80441	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCGGAGTGTCTTACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.964186567	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627700	171627720	170771190	170771210	80442	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGACACTCCGAGGCAACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.428148938	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627710	171627730	170771200	170771220	80443	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGAGACCGGTCGTTGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091236006	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627720	171627740	170771210	170771230	80444	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGTCTCCCTCTCCCTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.294554453	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627729	171627749	170771219	170771239	80445	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCACACCGGGCTAGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056393341	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627730	171627750	170771220	170771240	80446	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGCACACCGGGCTAGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.275426494	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627735	171627755	170771225	170771245	80447	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCAGACTGCACACCGGGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021070526	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627736	171627756	170771226	170771246	80448	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCAGACTGCACACCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.364300985	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627741	171627761	170771231	170771251	80449	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGGGTCAGACTGCACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.302696571	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627742	171627762	170771232	170771252	80450	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGCTGGGTCAGACTGCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.488859231	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627765	171627785	170771255	170771275	80451	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTGGGGGTGGTCTGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.300838499	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627765	171627785	170771255	170771275	80452	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACAGCAGACCACCCCCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.321131456	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627766	171627786	170771256	170771276	80453	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGCAGACCACCCCCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299198328	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627779	171627799	170771269	170771289	80454	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTCGGGCGCCCGGTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310074032	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627780	171627800	170771270	170771290	80455	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGACTCGGGCGCCCGGTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227620288	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627781	171627801	170771271	170771291	80456	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGACCGGGCGCCCGAGTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.194454564	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627781	171627801	170771271	170771291	80457	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGACTCGGGCGCCCGGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.029890052	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627782	171627802	170771272	170771292	80458	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGACTCGGGCGCCCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220437901	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627787	171627807	170771277	170771297	80459	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGTCCGCAGACTCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197954233	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627794	171627814	170771284	170771304	80460	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAGAGCGGTCCGCAGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.843764077	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627795	171627815	170771285	170771305	80461	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGTAGAGCGGTCCGCAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145676807	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627800	171627820	170771290	170771310	80462	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGACCGCTCTACCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.08853703	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627806	171627826	170771296	170771316	80463	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCTCTACCGCACCTGGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.349927004	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627808	171627828	170771298	170771318	80464	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAGAACCAGGTGCGGTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.522659208	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627812	171627832	170771302	170771322	80465	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCGCACCTGGTTCTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104585484	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627813	171627833	170771303	170771323	80466	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGCACCTGGTTCTGGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.133628537	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627816	171627836	170771306	170771326	80467	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCAGAGCCAGAACCAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.273353687	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627821	171627841	170771311	170771331	80468	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGGGCCCAGAGCCAGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.043733637	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627828	171627848	170771318	170771338	80469	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCTGGGCCCCGGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.184541893	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627836	171627856	170771326	170771346	80470	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCCGGGCCCCGTGGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014278551	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627837	171627857	170771327	170771347	80471	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCGGGCCCCGTGGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.137585183	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627838	171627858	170771328	170771348	80472	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGGGCCCCGTGGCTGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.363692178	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627839	171627859	170771329	170771349	80473	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTGGCAGCCACGGGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202983639	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627840	171627860	170771330	170771350	80474	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCTGGCAGCCACGGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428918136	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627841	171627861	170771331	170771351	80475	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCCTGGCAGCCACGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.113477944	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627845	171627865	170771335	170771355	80476	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGTGGCTGCCAGGGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006614116	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627846	171627866	170771336	170771356	80477	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGCGGCCCCTGGCAGCCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.028141093	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627846	171627866	170771336	170771356	80478	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTGGCTGCCAGGGGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.819629294	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627847	171627867	170771337	170771357	80479	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGCGGCCCCTGGCAGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.259258566	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627848	171627868	170771338	170771358	80480	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGGCGGCCCCTGGCAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.391135717	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627850	171627870	170771340	170771360	80481	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGCCAGGGGCCGCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.802425584	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627851	171627871	170771341	170771361	80482	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGCCAGGGGCCGCCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.705837113	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627857	171627877	170771347	170771367	80483	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCCCTTCCCGGCGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134468717	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627864	171627884	170771354	170771374	80484	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGCATCCTCCCTTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.233387283	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627867	171627887	170771357	170771377	80485	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGCGCGCATCCTCCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.205322846	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627868	171627888	170771358	170771378	80486	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGGGAGGATGCGCGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.292832681	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627869	171627889	170771359	170771379	80487	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGGGAGGATGCGCGCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.281386211	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627870	171627890	170771360	170771380	80488	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGGAGGATGCGCGCCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273819732	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627879	171627899	170771369	170771389	80489	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGCGCCACTGGGGTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400163705	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627886	171627906	170771376	170771396	80490	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTGGGGTGCGCCTGGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.709687809	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627887	171627907	170771377	170771397	80491	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAGCCAGGCGCACCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165346405	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627900	171627920	170771390	170771410	80492	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGAGGAGGGTGCCGCAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.125157503	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627905	171627925	170771395	170771415	80493	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGCACCCTCCTCCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078938646	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627909	171627929	170771399	170771419	80494	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACCCTCCTCCCGCAGTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.337278418	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627914	171627934	170771404	170771424	80495	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCCGACCACTGCGGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.840165325	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627915	171627935	170771405	170771425	80496	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTCCGACCACTGCGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.390754014	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627915	171627935	170771405	170771425	80497	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCCCGCAGTGGTCGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.336707896	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627918	171627938	170771408	170771428	80498	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCTTCCGACCACTGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.154359127	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627921	171627941	170771411	170771431	80499	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCACCTCTTCCGACCACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148227657	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627922	171627942	170771412	170771432	80500	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCACCTCTTCCGACCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.315012972	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627943	171627963	170771433	170771453	80501	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGCGCCGTTCGTGTCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145183671	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627944	171627964	170771434	170771454	80502	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCGCCGTTCGTGTCTACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263772013	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627949	171627969	170771439	170771459	80503	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGTTCGTGTCTACACGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0478552	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627951	171627971	170771441	170771461	80504	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACACCCGTGTAGACACGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.063011691	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627959	171627979	170771449	170771469	80505	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTACACGGGTGTGGAGATAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.821584071	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627960	171627980	170771450	170771470	80506	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACACGGGTGTGGAGATAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.263307529	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171627973	171627993	170771463	170771483	80507	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAACTGGGCGATTCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02623016	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628001	171628021	170771491	170771511	80508	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTACACTACCATTCTTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.278114142	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628005	171628025	170771495	170771515	80509	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTACCATTCTTTGACCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103793314	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628012	171628032	170771502	170771522	80510	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGCACCGGCCGGTCAAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.525046946	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628023	171628043	170771513	170771533	80511	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTGGTGCGTGTGCACCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.502649355	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628027	171628047	170771517	170771537	80512	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGGAGTTGGTGCGTGTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050219516	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628041	171628061	170771531	170771551	80513	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTATTTGCGGGGAAGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.285942918	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628046	171628066	170771536	170771556	80514	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCCCCGCAAATAACGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.170808733	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628062	171628082	170771552	170771572	80515	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGATGGCCCAGCCCATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.098363717	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628063	171628083	170771553	170771573	80516	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGATGGCCCAGCCCATCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.004364044	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628077	171628097	170771567	170771587	80517	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGTCGGGAAGCCCTGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.612077762	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628082	171628102	170771572	170771592	80518	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGGGGGTCGGGAAGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140929006	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628100	171628120	170771590	170771610	80519	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAAGGGCAAGGACTGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.416870682	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628102	171628122	170771592	170771612	80520	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCTCAGTCCTTGCCCTTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.174625485	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628104	171628124	170771594	170771614	80521	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGGGCAAGGGCAAGGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.552914184	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628105	171628125	170771595	170771615	80522	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCGGGCAAGGGCAAGGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.511987919	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628112	171628132	170771602	170771622	80523	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGAATTCCGGGCAAGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.368381859	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628117	171628137	170771607	170771627	80524	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTAAAAGAATTCCGGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.424247002	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628118	171628138	170771608	170771628	80525	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGTAAAAGAATTCCGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.702467391	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628185	171628205	170771675	170771695	80526	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTAGCCATACAAATTTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.010354121	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628192	171628212	170771682	170771702	80527	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATACAAATTTCGATGGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.380162964	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628193	171628213	170771683	170771703	80528	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAATTCCATCGAAATTTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.222837338	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628213	171628233	170771703	170771723	80529	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGACAAATCATTTATATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.430385265	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628214	171628234	170771704	170771724	80530	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACAAATCATTTATATTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.231495908	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628234	171628254	170771724	170771744	80531	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAAGATGAGAATAAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133278931	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628235	171628255	170771725	170771745	80532	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCATAAGATGAGAATAAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.738689023	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628240	171628260	170771730	170771750	80533	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCATCTCATAAGATGAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.127670294	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628316	171628336	170771806	170771826	80534	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTACTCTACACTGAGCCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.535047611	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628334	171628354	170771824	170771844	80535	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGTTACTTTAAATGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.550450771	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628335	171628355	170771825	170771845	80536	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGCATTTAAAGTAACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.417529284	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628415	171628435	170771905	170771925	80537	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACTTCCAGGGGTTCTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021665955	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628416	171628436	170771906	170771926	80538	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCGACTTCCAGGGGTTCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.717317716	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628441	171628461	170771931	170771951	80539	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAAAATCTGAAAAGGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.595784167	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628515	171628535	170772005	170772025	80540	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAAAAATAAGTTGGATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.132129003	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628638	171628658	170772128	170772148	80541	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGATGCTGGAATTTCAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186117066	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628640	171628660	170772130	170772150	80542	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTGAAATTCCAGCATCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.756476343	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628652	171628672	170772142	170772162	80543	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATGAAATACCTAGAGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.051851894	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628678	171628698	170772168	170772188	80544	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGCTCTGGAATTCTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.098498366	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628679	171628699	170772169	170772189	80545	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAAGCTCTGGAATTCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19261205	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628684	171628704	170772174	170772194	80546	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGTAGAAAGCTCTGGAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021073352	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628692	171628712	170772182	170772202	80547	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGAGCGTAGGTAGAAAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.21580261	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628693	171628713	170772183	170772203	80548	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCTTTCTACCTACGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114765566	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628705	171628725	170772195	170772215	80549	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGGCTCAACCGGTGAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.294215513	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628715	171628735	170772205	170772225	80550	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCACTGAGGATGTGGCTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.858821758	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628724	171628744	170772214	170772234	80551	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGAGAAAACACTGAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157185957	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628754	171628774	170772244	170772264	80552	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTAAACGCCGAAACTGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.287468033	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628755	171628775	170772245	170772265	80553	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTAAACGCCGAAACTGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.381616024	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628756	171628776	170772246	170772266	80554	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCTAAACGCCGAAACTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.311406333	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628757	171628777	170772247	170772267	80555	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCAGTTTCGGCGTTTAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.661538779	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628760	171628780	170772250	170772270	80556	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCAGTTCTAAACGCCGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.112653042	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628789	171628809	170772279	170772299	80557	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGACAGTTCACCTTCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.172991397	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628802	171628822	170772292	170772312	80558	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCAGGGAGGCCAGTCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.956739296	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628815	171628835	170772305	170772325	80559	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTAATATTTACAGCTCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.414995043	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628824	171628844	170772314	170772334	80560	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAATATTAACAATAGTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.597927167	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628827	171628847	170772317	170772337	80561	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAATATTAACAATAGTATAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.294276994	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628830	171628850	170772320	170772340	80562	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTAACAATAGTATAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.035124665	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628853	171628873	170772343	170772363	80563	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTTATAGTAACTGCAGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.713486161	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628857	171628877	170772347	170772367	80564	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATAGTAACTGCAGTTCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.439986399	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628928	171628948	170772418	170772438	80565	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTATAGAGTTAAATTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.298480669	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628930	171628950	170772420	170772440	80566	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCAATTTAACTCTATAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.642787802	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171628933	171628953	170772423	170772443	80567	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATTTAACTCTATAAGGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.027313499	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629014	171629034	170772504	170772524	80568	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCAAGGTCACACAGTTTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.038425474	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629015	171629035	170772505	170772525	80569	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCAAGGTCACACAGTTTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090834551	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629049	171629069	170772539	170772559	80570	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACAACCTGACTCCAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.628326915	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629057	171629077	170772547	170772567	80571	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGATTCCAGACTCTGGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078931321	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629064	171629084	170772554	170772574	80572	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTGCTAGGATTCCAGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134300098	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629078	171629098	170772568	170772588	80573	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCACTATATTACACTGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.337226935	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629130	171629150	170772620	170772640	80574	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTAAAAAATGAATGTAAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15621781	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629161	171629181	170772651	170772671	80575	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTGTGTATACAAATGGTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.488547826	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629169	171629189	170772659	170772679	80576	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTTCAAATGTGTATACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.208151588	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629196	171629216	170772686	170772706	80577	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATGCAGGAACAATATTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003428318	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629211	171629231	170772701	170772721	80578	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GGGGAAACATTACATGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.916811877	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629225	171629245	170772715	170772735	80579	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTTCCCCCACCAAGCTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044252891	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629230	171629250	170772720	170772740	80580	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GATCCTCAGGGAGCTTGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.415939011	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629231	171629251	170772721	170772741	80581	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTATCCTCAGGGAGCTTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040805528	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629232	171629252	170772722	170772742	80582	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTATCCTCAGGGAGCTTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.297572146	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629232	171629252	170772722	170772742	80583	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACCAAGCTCCCTGAGGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.354183534	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629233	171629253	170772723	170772743	80584	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCTATCCTCAGGGAGCTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.230716316	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629236	171629256	170772726	170772746	80585	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCTCTATCCTCAGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.66880397	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629243	171629263	170772733	170772753	80586	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGCACTATCCTCTATCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15498396	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629244	171629264	170772734	170772754	80587	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGCACTATCCTCTATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.31957024	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629278	171629298	170772768	170772788	80588	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCTCCTTCTCACCAGAGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252737946	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629279	171629299	170772769	170772789	80589	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GTCCTTCTCACCAGAGTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.363943752	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629283	171629303	170772773	170772793	80590	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GCCCTGCAACTCTGGTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.199394072	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629291	171629311	170772781	170772801	80591	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GACACTCAAGCCCTGCAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137187262	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629348	171629368	170772838	170772858	80592	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAAGCTACCTTGTAGTCTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.131470048	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-96901	chr2	171629390	171629410	170772880	170772900	80593	hg19	N/A	enh70020	N/A	N/A	enhancer	enh				GAGTAAAATAATTGCATAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204386114	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8827
enhrx-lit5889	chr2	171629545	171629565	170773035	170773055	80594	hg19					enhancer	enh				GTTCCTGAAGTCTGTGGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199740883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5890	chr2	171629550	171629570	170773040	170773060	80595	hg19					enhancer	enh				GCTCCACACTCCACAGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.465845011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5891	chr2	171629566	171629586	170773056	170773076	80596	hg19					enhancer	enh				GGAGTCCAAATAATACCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090148078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5892	chr2	171629567	171629587	170773057	170773077	80597	hg19					enhancer	enh				GAGTCCAAATAATACCAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279689049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5893	chr2	171629568	171629588	170773058	170773078	80598	hg19					enhancer	enh				GAGTCCAAATAATACCAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23805845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5894	chr2	171629571	171629591	170773061	170773081	80599	hg19					enhancer	enh				GCCAAATAATACCAACTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.583182336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5895	chr2	171629584	171629604	170773074	170773094	80600	hg19					enhancer	enh				GAGATTCTGAACCTCCCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.352445187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5896	chr2	171629631	171629651	170773121	170773141	80601	hg19					enhancer	enh				GACTACAATTTCTGAATCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004493816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5897	chr2	171629701	171629721	170773191	170773211	80602	hg19					enhancer	enh				GGGTTTGCTTTGGGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.041772134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5898	chr2	171629782	171629802	170773272	170773292	80603	hg19					enhancer	enh				GCTATACCTAGGAAAGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.509970264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5899	chr2	171629905	171629925	170773395	170773415	80604	hg19					enhancer	enh				GAGGCAGAACTGGAAGGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078962292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5900	chr2	171629912	171629932	170773402	170773422	80605	hg19					enhancer	enh				GCAGTGGAGGCAGAACTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.447473138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5901	chr2	171629916	171629936	170773406	170773426	80606	hg19					enhancer	enh				GCAGGCAGTGGAGGCAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.097392639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5902	chr2	171629925	171629945	170773415	170773435	80607	hg19					enhancer	enh				GAGGAAGTCAGCAGGCAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.095332979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5903	chr2	171629926	171629946	170773416	170773436	80608	hg19					enhancer	enh				GCACTGCCTGCTGACTTCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.025366693									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5904	chr2	171629928	171629948	170773418	170773438	80609	hg19					enhancer	enh				GCTAAGGAAGTCAGCAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.355370198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5905	chr2	171629934	171629954	170773424	170773444	80610	hg19					enhancer	enh				GAGATACCTAAGGAAGTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.445305022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5906	chr2	171629945	171629965	170773435	170773455	80611	hg19					enhancer	enh				GTCAAGGACTGGAGATACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.359664057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5907	chr2	171629966	171629986	170773456	170773476	80612	hg19					enhancer	enh				GCCCAAAAGAAAGAATTTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.331702954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5908	chr2	171629972	171629992	170773462	170773482	80613	hg19					enhancer	enh				GAGAAAGAATTTGATTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177703832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5909	chr2	171629993	171630013	170773483	170773503	80614	hg19					enhancer	enh				GACTGAGGAATAGTGATTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.887508607									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5910	chr2	171630009	171630029	170773499	170773519	80615	hg19					enhancer	enh				GTTCCCATACTGCCCAAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.233443806									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5911	chr2	171630029	171630049	170773519	170773539	80616	hg19					enhancer	enh				GATTACATTGTAGCCCCTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.134330757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5912	chr2	171630030	171630050	170773520	170773540	80617	hg19					enhancer	enh				GTTACATTGTAGCCCCTTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.413577938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5913	chr2	171630044	171630064	170773534	170773554	80618	hg19					enhancer	enh				GAACAAATGCTTCCCTTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.014424276									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5914	chr2	171630045	171630065	170773535	170773555	80619	hg19					enhancer	enh				GTAACAAATGCTTCCCTTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033376041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5915	chr2	171630046	171630066	170773536	170773556	80620	hg19					enhancer	enh				GATAACAAATGCTTCCCTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007090401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5916	chr2	171630114	171630134	170773604	170773624	80621	hg19					enhancer	enh				GCAGAATCTTATAGGTGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.3651247									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5917	chr2	171630115	171630135	170773605	170773625	80622	hg19					enhancer	enh				GTCAGAATCTTATAGGTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.123957599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5918	chr2	171630123	171630143	170773613	170773633	80623	hg19					enhancer	enh				GTGAGAAGTTCAGAATCTTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020749184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5919	chr2	171630171	171630191	170773661	170773681	80624	hg19					enhancer	enh				GTATAACTATGCTAAACTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.412995713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5920	chr2	171630172	171630192	170773662	170773682	80625	hg19					enhancer	enh				GATATAACTATGCTAAACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.743005173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5921	chr2	171630173	171630193	170773663	170773683	80626	hg19					enhancer	enh				GCATATAACTATGCTAAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.755002308									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5922	chr2	171630202	171630222	170773692	170773712	80627	hg19					enhancer	enh				GTAGGTGCTCATCAAATGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.209555433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5923	chr2	171630456	171630476	170773946	170773966	80628	hg19					enhancer	enh				GCCCATCCTCAAGCTATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.106213685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5924	chr2	171630519	171630539	170774009	170774029	80629	hg19					enhancer	enh				GGTATTTGGGTCAGGTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.024388978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5925	chr2	171630527	171630547	170774017	170774037	80630	hg19					enhancer	enh				GTTAAAACAGGTATTTGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122104562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5926	chr2	171630554	171630574	170774044	170774064	80631	hg19					enhancer	enh				GTTGAATAGTGCATGAAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.683400726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5927	chr2	171630591	171630611	170774081	170774101	80632	hg19					enhancer	enh				GTGCTGTTCCCATTGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262324624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5928	chr2	171630602	171630622	170774092	170774112	80633	hg19					enhancer	enh				GTTAACAGTCCTTGTGGCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029613046									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5929	chr2	171630603	171630623	170774093	170774113	80634	hg19					enhancer	enh				GTTTAACAGTCCTTGTGGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.361491477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5930	chr2	171630633	171630653	170774123	170774143	80635	hg19					enhancer	enh				GCTAATTTAGAACACAGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104206091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5931	chr2	171630666	171630686	170774156	170774176	80636	hg19					enhancer	enh				GTAGAAAGATCACTGACTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221897501									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5932	chr2	171630684	171630704	170774174	170774194	80637	hg19					enhancer	enh				GTAAACAAGTATCAGTACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.232028615									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5933	chr2	171630733	171630753	170774223	170774243	80638	hg19					enhancer	enh				GACAAGCAGATTATCTCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.015320712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5934	chr2	171630734	171630754	170774224	170774244	80639	hg19					enhancer	enh				GAGACAAGCAGATTATCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.005013016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5935	chr2	171630746	171630766	170774236	170774256	80640	hg19					enhancer	enh				GCTTGTCTCAATCACAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.680767176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5936	chr2	171630772	171630792	170774262	170774282	80641	hg19					enhancer	enh				GTTGCTTAGGGAAGCAAAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.018578073									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5937	chr2	171630773	171630793	170774263	170774283	80642	hg19					enhancer	enh				GATTGCTTAGGGAAGCAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.310919319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5938	chr2	171630785	171630805	170774275	170774295	80643	hg19					enhancer	enh				GGGATGATTAAAATTGCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.348999324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5939	chr2	171630786	171630806	170774276	170774296	80644	hg19					enhancer	enh				GGGGATGATTAAAATTGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.193092743									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5940	chr2	171630805	171630825	170774295	170774315	80645	hg19					enhancer	enh				GTTTGGAAAGATGTCCTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003591927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5941	chr2	171630806	171630826	170774296	170774316	80646	hg19					enhancer	enh				GAGTTTGGAAAGATGTCCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.416510838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5942	chr2	171630807	171630827	170774297	170774317	80647	hg19					enhancer	enh				GAAGTTTGGAAAGATGTCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.48967246									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5943	chr2	171630858	171630878	170774348	170774368	80648	hg19					enhancer	enh				GCAGTGTCCTTCCTATATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26372593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5944	chr2	171630867	171630887	170774357	170774377	80649	hg19					enhancer	enh				GCAGAGCCTGGCATATAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073312331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5945	chr2	171630871	171630891	170774361	170774381	80650	hg19					enhancer	enh				GTTCAGCAGAGCCTGGCATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.141502769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5946	chr2	171630879	171630899	170774369	170774389	80651	hg19					enhancer	enh				GTAAAGTGTTCAGCAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.559539882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5947	chr2	171630902	171630922	170774392	170774412	80652	hg19					enhancer	enh				GAAGGATTAAATGGGATAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-4.607757035									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5948	chr2	171630917	171630937	170774407	170774427	80653	hg19					enhancer	enh				GTCCTTATAATAATCCACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.1298854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5949	chr2	171630920	171630940	170774410	170774430	80654	hg19					enhancer	enh				GTTATAATAATCCACCAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.338637459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5950	chr2	171630928	171630948	170774418	170774438	80655	hg19					enhancer	enh				GATCCACCAAAGGTGGCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.530091755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5951	chr2	171630933	171630953	170774423	170774443	80656	hg19					enhancer	enh				GCACCATGGTGCCACCTTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.346821738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5952	chr2	171630936	171630956	170774426	170774446	80657	hg19					enhancer	enh				GATCACCATGGTGCCACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.090939862									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5953	chr2	171630948	171630968	170774438	170774458	80658	hg19					enhancer	enh				GCTGAAAAATGGGGATCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034988467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5954	chr2	171630997	171631017	170774487	170774507	80659	hg19					enhancer	enh				GTGACTTCTCCAGGCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.459111451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5955	chr2	171630998	171631018	170774488	170774508	80660	hg19					enhancer	enh				GTGACTTCTCCAGGCTCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099524455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5956	chr2	171631008	171631028	170774498	170774518	80661	hg19					enhancer	enh				GAGGCTCACCTGGGAAGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135489096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5957	chr2	171631009	171631029	170774499	170774519	80662	hg19					enhancer	enh				GTGTCACTTCCCAGGTGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239978528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5958	chr2	171631014	171631034	170774504	170774524	80663	hg19					enhancer	enh				GACCTGGGAAGTGACAGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037618468									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5959	chr2	171631015	171631035	170774505	170774525	80664	hg19					enhancer	enh				GCCTGGGAAGTGACAGGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.293202367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5960	chr2	171631018	171631038	170774508	170774528	80665	hg19					enhancer	enh				GCCCAGTTCCTGTCACTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130581952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5961	chr2	171631380	171631400	170774870	170774890	80666	hg19					enhancer	enh				GAAAGATGGGGCTCTTGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.882435324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5962	chr2	171631381	171631401	170774871	170774891	80667	hg19					enhancer	enh				GAAAAGATGGGGCTCTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145619193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5963	chr2	171631385	171631405	170774875	170774895	80668	hg19					enhancer	enh				GACTCAAAAGATGGGGCTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.350679811									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5964	chr2	171631386	171631406	170774876	170774896	80669	hg19					enhancer	enh				GTACTCAAAAGATGGGGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197186061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5965	chr2	171631393	171631413	170774883	170774903	80670	hg19					enhancer	enh				GTAAAGAATACTCAAAAGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.261127575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5966	chr2	171631394	171631414	170774884	170774904	80671	hg19					enhancer	enh				GTAAAGAATACTCAAAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.394819642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5967	chr2	171631419	171631439	170774909	170774929	80672	hg19					enhancer	enh				GATTACACTGAATTCCTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.424364143									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5968	chr2	171631422	171631442	170774912	170774932	80673	hg19					enhancer	enh				GAAGGAATTCAGTGTAATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.028620588									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5969	chr2	171631476	171631496	170774966	170774986	80674	hg19					enhancer	enh				GAAGCCAGACCTAGCAGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.316673252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5970	chr2	171631477	171631497	170774967	170774987	80675	hg19					enhancer	enh				GAGCCAGACCTAGCAGAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.082363136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5971	chr2	171631482	171631502	170774972	170774992	80676	hg19					enhancer	enh				GACCCATGCTCTGCTAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.464357854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5972	chr2	171631487	171631507	170774977	170774997	80677	hg19					enhancer	enh				GATGGAGACCCATGCTCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.203827405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5973	chr2	171631489	171631509	170774979	170774999	80678	hg19					enhancer	enh				GCAGAGCATGGGTCTCCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.576482421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5974	chr2	171631490	171631510	170774980	170775000	80679	hg19					enhancer	enh				GAGAGCATGGGTCTCCATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.661018298									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5975	chr2	171631494	171631514	170774984	170775004	80680	hg19					enhancer	enh				GCATGGGTCTCCATCAAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022844901									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5976	chr2	171631495	171631515	170774985	170775005	80681	hg19					enhancer	enh				GATGGGTCTCCATCAAGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139102489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5977	chr2	171631506	171631526	170774996	170775016	80682	hg19					enhancer	enh				GGACAGATCCCAGCCCTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.510803917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5978	chr2	171631535	171631555	170775025	170775045	80683	hg19					enhancer	enh				GTTTCACCAGGTGAAAATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.375455288									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5979	chr2	171631612	171631632	170775102	170775122	80684	hg19					enhancer	enh				GTGAAGATCCTAGAGCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.477568653									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5980	chr2	171631617	171631637	170775107	170775127	80685	hg19					enhancer	enh				GATCCTAGAGCTAGAAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.468465586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5981	chr2	171631630	171631650	170775120	170775140	80686	hg19					enhancer	enh				GAAAGGAGAGGACTGCTCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.004731189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5982	chr2	171631633	171631653	170775123	170775143	80687	hg19					enhancer	enh				GGAGAGGACTGCTCTAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060792696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5983	chr2	171631634	171631654	170775124	170775144	80688	hg19					enhancer	enh				GAGAGGACTGCTCTAAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.008720831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5984	chr2	171631639	171631659	170775129	170775149	80689	hg19					enhancer	enh				GACTGCTCTAAAGGTGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.114969024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5985	chr2	171631643	171631663	170775133	170775153	80690	hg19					enhancer	enh				GCTCTAAAGGTGGGCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.128811951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5986	chr2	171631646	171631666	170775136	170775156	80691	hg19					enhancer	enh				GCTAAAGGTGGGCCAGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.356654554									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5987	chr2	171631707	171631727	170775197	170775217	80692	hg19					enhancer	enh				GAGGAGGATCGCTTAAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.52252967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5988	chr2	171631986	171632006	170775476	170775496	80693	hg19					enhancer	enh				GACATTTATATACAGGTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.32119156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5989	chr2	171631987	171632007	170775477	170775497	80694	hg19					enhancer	enh				GCATTTATATACAGGTACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153811363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5990	chr2	171631988	171632008	170775478	170775498	80695	hg19					enhancer	enh				GATTTATATACAGGTACCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199171793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5991	chr2	171631995	171632015	170775485	170775505	80696	hg19					enhancer	enh				GTACAGGTACCCAGGGGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.115484624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5992	chr2	171632006	171632026	170775496	170775516	80697	hg19					enhancer	enh				GACAGAGTTCCACAATCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200626373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5993	chr2	171632007	171632027	170775497	170775517	80698	hg19					enhancer	enh				GCACAGAGTTCCACAATCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19292817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5994	chr2	171632024	171632044	170775514	170775534	80699	hg19					enhancer	enh				GTGAAATGAAAGTGTCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07218994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5995	chr2	171632025	171632045	170775515	170775535	80700	hg19					enhancer	enh				GTGAAATGAAAGTGTCTCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.384381434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5996	chr2	171632080	171632100	170775570	170775590	80701	hg19					enhancer	enh				GAAGCAATAATGAACTAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.393092817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5997	chr2	171632118	171632138	170775608	170775628	80702	hg19					enhancer	enh				GTTGCTGCCCTAGATAACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274988189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5998	chr2	171632160	171632180	170775650	170775670	80703	hg19					enhancer	enh				GTTGTGGAAGACCAAACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.221011859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit5999	chr2	171632192	171632212	170775682	170775702	80704	hg19					enhancer	enh				GCAGAACAGCACGGCATCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299737755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6000	chr2	171632202	171632222	170775692	170775712	80705	hg19					enhancer	enh				GTAAAGTCTATCAGAACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151710242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6001	chr2	171632227	171632247	170775717	170775737	80706	hg19					enhancer	enh				GCTCTCCAAGAGGCTCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.572247461									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6002	chr2	171632237	171632257	170775727	170775747	80707	hg19					enhancer	enh				GAATTCGATTAGCTCTCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178411929									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6003	chr2	171632251	171632271	170775741	170775761	80708	hg19					enhancer	enh				GCGAATTAACGTATGTAATGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196051141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96902	chr2	171632337	171632357	170775827	170775847	80709	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAGGAGCATAAGTCAATATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.222795129	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632343	171632363	170775833	170775853	80710	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GATAAGTCAATATAAAGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.220323074	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632420	171632440	170775910	170775930	80711	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAAAATTCAGGGCCAAGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204276723	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632441	171632461	170775931	170775951	80712	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTATTCCAGAAATCCCTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.042596447	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632448	171632468	170775938	170775958	80713	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GATTACCTACTGAGGGATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.181045499	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632497	171632517	170775987	170776007	80714	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GGTGTGGGAACAAGTGTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250746654	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632498	171632518	170775988	170776008	80715	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTGTGGGAACAAGTGTTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.27509796	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632499	171632519	170775989	170776009	80716	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTGTGGGAACAAGTGTTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.018391533	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632504	171632524	170775994	170776014	80717	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAACAAGTGTTAGAGGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.931215219	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632523	171632543	170776013	170776033	80718	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAGGAAGTGGATTGTTACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149843894	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632653	171632673	170776143	170776163	80719	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GCGAAAATCAGTCCTATGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.00423949	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632667	171632687	170776157	170776177	80720	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTACCTAAATTACCTGATCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.354805961	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632723	171632743	170776213	170776233	80721	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTAAACACATGAGAACTTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.145474298	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632814	171632834	170776304	170776324	80722	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTACCATAGCTTGAGATACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.463885398	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632819	171632839	170776309	170776329	80723	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTTCCACAGTATCTCAAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.833612981	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171632854	171632874	170776344	170776364	80724	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GCTGGTCACATGTACTCTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.174579094	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633211	171633231	170776701	170776721	80725	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GACACCAATAAACTGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.475220426	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633400	171633420	170776890	170776910	80726	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAAGCACAAACGATAACTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.571149861	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633401	171633421	170776891	170776911	80727	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAAGCACAAACGATAACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.789999145	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633402	171633422	170776892	170776912	80728	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAGAAGCACAAACGATAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.234651916	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633427	171633447	170776917	170776937	80729	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTCCCCACCCCGTCCCCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165042374	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633436	171633456	170776926	170776946	80730	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GATTAAGCCTTCTGGGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.74586422	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633437	171633457	170776927	170776947	80731	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAATTAAGCCTTCTGGGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.118394434	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633438	171633458	170776928	170776948	80732	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAAATTAAGCCTTCTGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.098256813	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633442	171633462	170776932	170776952	80733	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GAGAGAAATTAAGCCTTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254133769	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633443	171633463	170776933	170776953	80734	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTAGAGAAATTAAGCCTTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.227496933	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633444	171633464	170776934	170776954	80735	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GCTAGAGAAATTAAGCCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047681741	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633445	171633465	170776935	170776955	80736	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTCTAGAGAAATTAAGCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.444542557	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633481	171633501	170776971	170776991	80737	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GTTTCATAATCCAGAAGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.502615338	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633493	171633513	170776983	170777003	80738	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GACTGTAAAACCTCATTCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.097154738	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633566	171633586	170777056	170777076	80739	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GCAGAACACAGTCTGTCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102627446	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-96902	chr2	171633567	171633587	170777057	170777077	80740	hg19	N/A	N/A	N/A	Enhatls103718	enhancer	enh				GACAGAACACAGTCTGTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091317529	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8828
enhrx-lit6004	chr2	171633665	171633685	170777155	170777175	80741	hg19					enhancer	enh				GAGACAAGACAGATACTGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.344389152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6005	chr2	171633791	171633811	170777281	170777301	80742	hg19					enhancer	enh				GTAGTAGAAATGTTTACATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.729752143									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6006	chr2	171633973	171633993	170777463	170777483	80743	hg19					enhancer	enh				GTACTATTTAGGACAAGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.594401516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6007	chr2	171633983	171634003	170777473	170777493	80744	hg19					enhancer	enh				GCTAAATAGTAAGAAGACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.75586034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6008	chr2	171634045	171634065	170777535	170777555	80745	hg19					enhancer	enh				GAAGGATAGGCAACATAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.02915783									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6009	chr2	171634084	171634104	170777574	170777594	80746	hg19					enhancer	enh				GCCATTTAGAAGTGTATGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.041115988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6010	chr2	171634085	171634105	170777575	170777595	80747	hg19					enhancer	enh				GCCATTTAGAAGTGTATGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.029314428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6011	chr2	171634088	171634108	170777578	170777598	80748	hg19					enhancer	enh				GCCCTGACATACACTTCTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045146189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6012	chr2	171634111	171634131	170777601	170777621	80749	hg19					enhancer	enh				GTCAGTGTTAATAAAATACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000503044									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6013	chr2	171634112	171634132	170777602	170777622	80750	hg19					enhancer	enh				GCAGTGTTAATAAAATACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216388763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6014	chr2	171634228	171634248	170777718	170777738	80751	hg19					enhancer	enh				GTCTAATTGCTTAAAAGGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.480808772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6015	chr2	171634229	171634249	170777719	170777739	80752	hg19					enhancer	enh				GTTCTAATTGCTTAAAAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.100334334									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6016	chr2	171634265	171634285	170777755	170777775	80753	hg19					enhancer	enh				GAAATTTAATTGGGTGACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.318359973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6017	chr2	171634268	171634288	170777758	170777778	80754	hg19					enhancer	enh				GTCACCCAATTAAATTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.425574548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6018	chr2	171634282	171634302	170777772	170777792	80755	hg19					enhancer	enh				GTTTGAAAGGCCAGAAATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.79193055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6019	chr2	171634294	171634314	170777784	170777804	80756	hg19					enhancer	enh				GAGTGCTAATCCATGCATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.169907368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6020	chr2	171634336	171634356	170777826	170777846	80757	hg19					enhancer	enh				GCAATTGTTACTATAGATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.832674313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6021	chr2	171634442	171634462	170777932	170777952	80758	hg19					enhancer	enh				GCAAGTAAAATACAGAATACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19740757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6022	chr2	171634443	171634463	170777933	170777953	80759	hg19					enhancer	enh				GACAAGTAAAATACAGAATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.466687708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6023	chr2	171634488	171634508	170777978	170777998	80760	hg19					enhancer	enh				GAATAAGTATCAAAGGGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.404099309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6024	chr2	171634496	171634516	170777986	170778006	80761	hg19					enhancer	enh				GTGAAAGAAATAAGTATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.402259029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6025	chr2	171634604	171634624	170778094	170778114	80762	hg19					enhancer	enh				GCCTCAACTAGTTGAAGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068078315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-96903	chr2	171634765	171634785	170778255	170778275	80763	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GTAGGAGATGACTACAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428042106	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634766	171634786	170778256	170778276	80764	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GAGTAGGAGATGACTACAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.377996154	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634770	171634790	170778260	170778280	80765	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GAGAAAGTAGGAGATGACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.9438269	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634835	171634855	170778325	170778345	80766	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GTTGATCATAAACACATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085394146	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634837	171634857	170778327	170778347	80767	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GTGATCATAAACACATTTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.071392282	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634857	171634877	170778347	170778367	80768	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GGGATTACTGACAAATTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051986108	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634868	171634888	170778358	170778378	80769	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GCAAATTAGTAGGTACTATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.179035177	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171634992	171635012	170778482	170778502	80770	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GAAAACGAAAAATGTCCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.204770391	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171635009	171635029	170778499	170778519	80771	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GATTTACAACAAAAGCCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.511907427	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171635012	171635032	170778502	170778522	80772	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GATAATTTACAACAAAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.27095763	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171635084	171635104	170778574	170778594	80773	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GTATAGCAAATCAGTGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248462605	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171635146	171635166	170778636	170778656	80774	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GAAAAAGAGCCTTGTTACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050223702	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-96903	chr2	171635157	171635177	170778647	170778667	80775	hg19	N/A	N/A	N/A	Enhatls103719	enhancer	enh				GTAGATTACCATATGTAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.174532869	ERICH2	chr2	170770377	170798977	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8829
enhrx-lit6026	chr2	171635339	171635359	170778829	170778849	80776	hg19					enhancer	enh				GTTATCACTCAAAGAACATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378689637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6027	chr2	171635340	171635360	170778830	170778850	80777	hg19					enhancer	enh				GCTTATCACTCAAAGAACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.188735424									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6028	chr2	171635341	171635361	170778831	170778851	80778	hg19					enhancer	enh				GCTTATCACTCAAAGAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.135290548									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6029	chr2	171635346	171635366	170778836	170778856	80779	hg19					enhancer	enh				GCTTTGAGTGATAAGCAGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.768885644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6030	chr2	171635352	171635372	170778842	170778862	80780	hg19					enhancer	enh				GTGATAAGCAGTGTTGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.777943267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6031	chr2	171635359	171635379	170778849	170778869	80781	hg19					enhancer	enh				GCAGTGTTGGAACTGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020844525									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6032	chr2	171635361	171635381	170778851	170778871	80782	hg19					enhancer	enh				GAGTGTTGGAACTGGAGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.910625199									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6033	chr2	171635378	171635398	170778868	170778888	80783	hg19					enhancer	enh				GAAGGGGTGTTCCACCTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.819543552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6034	chr2	171635391	171635411	170778881	170778901	80784	hg19					enhancer	enh				GGTTTATCTACCTCAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328244589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6035	chr2	171635392	171635412	170778882	170778902	80785	hg19					enhancer	enh				GCTCCTGAGGTAGATAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336238213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6036	chr2	171635393	171635413	170778883	170778903	80786	hg19					enhancer	enh				GTCCTGAGGTAGATAAACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.070983925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6037	chr2	171635394	171635414	170778884	170778904	80787	hg19					enhancer	enh				GCCTGAGGTAGATAAACCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.223621978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6038	chr2	171635394	171635414	170778884	170778904	80788	hg19					enhancer	enh				GCGGGGTTTATCTACCTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114347949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6039	chr2	171635397	171635417	170778887	170778907	80789	hg19					enhancer	enh				GCCCCGGGGTTTATCTACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.370074383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6040	chr2	171635412	171635432	170778902	170778922	80790	hg19					enhancer	enh				GCTGCATCTGATTTATCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.127299725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6041	chr2	171635413	171635433	170778903	170778923	80791	hg19					enhancer	enh				GACTGCATCTGATTTATCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263268847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6042	chr2	171635414	171635434	170778904	170778924	80792	hg19					enhancer	enh				GACTGCATCTGATTTATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.493578186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6043	chr2	171635415	171635435	170778905	170778925	80793	hg19					enhancer	enh				GGATAAATCAGATGCAGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.323312519									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6044	chr2	171635486	171635506	170778976	170778996	80794	hg19					enhancer	enh				GTTTGAGAGGCAGATGCAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.664104857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6045	chr2	171635498	171635518	170778988	170779008	80795	hg19					enhancer	enh				GCTCTCAAACTGCTTCTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.550640574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6046	chr2	171635500	171635520	170778990	170779010	80796	hg19					enhancer	enh				GCTTGCAAGAAGCAGTTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.111966643									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6047	chr2	171635539	171635559	170779029	170779049	80797	hg19					enhancer	enh				GTCCTCTGAAAGCAAATTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.78780727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6048	chr2	171635540	171635560	170779030	170779050	80798	hg19					enhancer	enh				GTCCTCTGAAAGCAAATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.541659996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6049	chr2	171635541	171635561	170779031	170779051	80799	hg19					enhancer	enh				GTAATTTGCTTTCAGAGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081293294									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6050	chr2	171635542	171635562	170779032	170779052	80800	hg19					enhancer	enh				GAATTTGCTTTCAGAGGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.133204869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6051	chr2	171635545	171635565	170779035	170779055	80801	hg19					enhancer	enh				GTTGCTTTCAGAGGACAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130149446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6052	chr2	171635571	171635591	170779061	170779081	80802	hg19					enhancer	enh				GTGTAGCCAATAAGCTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.510120891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6053	chr2	171635580	171635600	170779070	170779090	80803	hg19					enhancer	enh				GTACACACCTGTGAAGCTTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.637816353									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6054	chr2	171635612	171635632	170779102	170779122	80804	hg19					enhancer	enh				GAACTCTGGGTGAAGTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301470153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6055	chr2	171635614	171635634	170779104	170779124	80805	hg19					enhancer	enh				GGTACTTCACCCAGAGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336298439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6056	chr2	171635622	171635642	170779112	170779132	80806	hg19					enhancer	enh				GACCCAGAGTTGAAGGTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.001467784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6057	chr2	171635623	171635643	170779113	170779133	80807	hg19					enhancer	enh				GCCCAGAGTTGAAGGTAAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.208032213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6058	chr2	171635627	171635647	170779117	170779137	80808	hg19					enhancer	enh				GCCCTGTTTACCTTCAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141874541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6059	chr2	171635652	171635672	170779142	170779162	80809	hg19					enhancer	enh				GCTAGAGAAAAATGATCAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252227506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6060	chr2	171635664	171635684	170779154	170779174	80810	hg19					enhancer	enh				GATCAAGTAGGAAAAAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.100335189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6061	chr2	171635669	171635689	170779159	170779179	80811	hg19					enhancer	enh				GAGTAGGAAAAAACATTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.175982844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6062	chr2	171635670	171635690	170779160	170779180	80812	hg19					enhancer	enh				GTAGGAAAAAACATTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.546429313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6063	chr2	171635671	171635691	170779161	170779181	80813	hg19					enhancer	enh				GTAGGAAAAAACATTGGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.457601725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6064	chr2	171635685	171635705	170779175	170779195	80814	hg19					enhancer	enh				GGAGTGGGGAGATCTTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.076874679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6065	chr2	171635686	171635706	170779176	170779196	80815	hg19					enhancer	enh				GAGTGGGGAGATCTTTGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.314084956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6066	chr2	171635761	171635781	170779251	170779271	80816	hg19					enhancer	enh				GTCCGCTCTCCACCCTGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.381386017									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6067	chr2	171635772	171635792	170779262	170779282	80817	hg19					enhancer	enh				GCTATGAAGCCAGCAGCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.19337104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6068	chr2	171635775	171635795	170779265	170779285	80818	hg19					enhancer	enh				GAGACTATGAAGCCAGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05690639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6069	chr2	171635776	171635796	170779266	170779286	80819	hg19					enhancer	enh				GCAGACTATGAAGCCAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.212994375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6070	chr2	171635778	171635798	170779268	170779288	80820	hg19					enhancer	enh				GTGCTGGCTTCATAGTCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.019670686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6071	chr2	171635814	171635834	170779304	170779324	80821	hg19					enhancer	enh				GCCAAAAGATTTCATTTAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.618594284									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6072	chr2	171635817	171635837	170779307	170779327	80822	hg19					enhancer	enh				GCCAACCTAAATGAAATCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263955827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6073	chr2	171635892	171635912	170779382	170779402	80823	hg19					enhancer	enh				GATACTTCTTGTGGCTGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055886135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6074	chr2	171635893	171635913	170779383	170779403	80824	hg19					enhancer	enh				GTCCCAGCCACAAGAAGTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.09407679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6075	chr2	171635898	171635918	170779388	170779408	80825	hg19					enhancer	enh				GTCCACATACTTCTTGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.285567237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6076	chr2	171635902	171635922	170779392	170779412	80826	hg19					enhancer	enh				GTAGAGTCCACATACTTCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085433303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6077	chr2	171635924	171635944	170779414	170779434	80827	hg19					enhancer	enh				GAACCACAAGTTTCAAACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099109545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6078	chr2	171635925	171635945	170779415	170779435	80828	hg19					enhancer	enh				GACCACAAGTTTCAAACTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.209527339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6079	chr2	171635929	171635949	170779419	170779439	80829	hg19					enhancer	enh				GCCCAGAAGTTTGAAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.25222556									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6080	chr2	171635993	171636013	170779483	170779503	80830	hg19					enhancer	enh				GAGACAAAATCTTTCCCACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091045074									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6081	chr2	171636017	171636037	170779507	170779527	80831	hg19					enhancer	enh				GTTAACTACAAGCAATTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.118215244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6082	chr2	171636018	171636038	170779508	170779528	80832	hg19					enhancer	enh				GTTAACTACAAGCAATTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06179583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6083	chr2	171636107	171636127	170779597	170779617	80833	hg19					enhancer	enh				GCTTGACCAAAAAATCCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.344124293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6084	chr2	171636126	171636146	170779616	170779636	80834	hg19					enhancer	enh				GCTTTCAAGCATAAAGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.555866423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6085	chr2	171636127	171636147	170779617	170779637	80835	hg19					enhancer	enh				GCTTTCAAGCATAAAGATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397882574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6086	chr2	171636128	171636148	170779618	170779638	80836	hg19					enhancer	enh				GTTTCAAGCATAAAGATTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091332718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6087	chr2	171636135	171636155	170779625	170779645	80837	hg19					enhancer	enh				GCATAAAGATTGAGGGGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224243633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6088	chr2	171636172	171636192	170779662	170779682	80838	hg19					enhancer	enh				GTCAGTCAGCGCTGAGTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334710814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6089	chr2	171636195	171636215	170779685	170779705	80839	hg19					enhancer	enh				GTGAAAAAAAATTGTATCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.3583772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6090	chr2	171636287	171636307	170779777	170779797	80840	hg19					enhancer	enh				GATTTACTTGAGGTATAAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.084190474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6091	chr2	171636294	171636314	170779784	170779804	80841	hg19					enhancer	enh				GACCTCAAGTAAATGCCTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.528609872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6092	chr2	171636298	171636318	170779788	170779808	80842	hg19					enhancer	enh				GTCCAAAGAGGCATTTACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.613819335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6093	chr2	171636311	171636331	170779801	170779821	80843	hg19					enhancer	enh				GATCTTGGTCTGCGTCCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.203039075									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6094	chr2	171636341	171636361	170779831	170779851	80844	hg19					enhancer	enh				GACTTAATACCTCACCAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.230940542									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6095	chr2	171636352	171636372	170779842	170779862	80845	hg19					enhancer	enh				GTACAGAGACCTGTGTTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.338114626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6096	chr2	171636357	171636377	170779847	170779867	80846	hg19					enhancer	enh				GACATTTACAGAGACCTGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.317594112									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6097	chr2	171636515	171636535	170780005	170780025	80847	hg19					enhancer	enh				GTAAATATACCCAACATGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.680627234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6098	chr2	171636568	171636588	170780058	170780078	80848	hg19					enhancer	enh				GTGGAACATATTTATGCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.033148994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6099	chr2	171636569	171636589	170780059	170780079	80849	hg19					enhancer	enh				GCTAGCATAAATATGTTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.187634805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6100	chr2	171636588	171636608	170780078	170780098	80850	hg19					enhancer	enh				GAATCAGGTTAGACATTCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.619312772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6101	chr2	171636604	171636624	170780094	170780114	80851	hg19					enhancer	enh				GATAAAATTACAGAGTTAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327853326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6102	chr2	171636696	171636716	170780186	170780206	80852	hg19					enhancer	enh				GTTAACTACAATTACAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024571154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6103	chr2	171636720	171636740	170780210	170780230	80853	hg19					enhancer	enh				GACAGATCTGTTAGAGTATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105201848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6104	chr2	171636749	171636769	170780239	170780259	80854	hg19					enhancer	enh				GAGCCCCTAACTAAGAAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.170871062									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6105	chr2	171636820	171636840	170780310	170780330	80855	hg19					enhancer	enh				GTGAAGAGGAAATTGACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138290989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6106	chr2	171636821	171636841	170780311	170780331	80856	hg19					enhancer	enh				GTGAAGAGGAAATTGACCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.711594932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6107	chr2	171636839	171636859	170780329	170780349	80857	hg19					enhancer	enh				GTCAAAGAATCGGAGGCCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.621045795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6108	chr2	171636847	171636867	170780337	170780357	80858	hg19					enhancer	enh				GCACAGTTTCAAAGAATCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295133523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6109	chr2	171636850	171636870	170780340	170780360	80859	hg19					enhancer	enh				GCTTGCACAGTTTCAAAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.259616167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6110	chr2	171636990	171637010	170780480	170780500	80860	hg19					enhancer	enh				GACTCAATGACCTGAAGTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.058540288									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6111	chr2	171637099	171637119	170780589	170780609	80861	hg19					enhancer	enh				GTGAGTTACATCCCTTAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.590044369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6112	chr2	171637137	171637157	170780627	170780647	80862	hg19					enhancer	enh				GTGTGCTTTAGAATAAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055684766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6113	chr2	171673298	171673320	170816788	170816810	80863	hg19					enhancer	enh				GAAATCACGAGGCCGTTGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.411016726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6114	chr2	171673356	171673376	170816846	170816866	80864	hg19					enhancer	enh				GCACGGCTCCGGGGTAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				0.060630095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6115	chr2	171673357	171673379	170816847	170816869	80865	hg19					enhancer	enh				GCTGCACGGCTCCGGGGTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.222626628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6116	chr2	171673361	171673382	170816851	170816872	80866	hg19					enhancer	enh				GCGGCTGCACGGCTCCGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				0.061137834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6117	chr2	171673365	171673385	170816855	170816875	80867	hg19					enhancer	enh				GAGGCGGCTGCACGGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.290209553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6118	chr2	171673367	171673387	170816857	170816877	80868	hg19					enhancer	enh				GAGAGGCGGCTGCACGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.269444745									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6119	chr2	171673373	171673395	170816863	170816885	80869	hg19					enhancer	enh				GAGATTCGGAGAGGCGGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.750946886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6120	chr2	171673373	171673393	170816863	170816883	80870	hg19					enhancer	enh				GATTCGGAGAGGCGGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.233289559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6121	chr2	171673384	171673405	170816874	170816895	80871	hg19					enhancer	enh				GGAGAAGAGAGAGATTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.116368699									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6122	chr2	171673384	171673404	170816874	170816894	80872	hg19					enhancer	enh				GAGAAGAGAGAGATTCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.844742523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6123	chr2	171673419	171673440	170816909	170816930	80873	hg19					enhancer	enh				GAGAGGGAACTAGCGAGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.001891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6124	chr2	171673431	171673453	170816921	170816943	80874	hg19					enhancer	enh				GCGAGAACGAGGAAGCAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.431453621									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6125	chr2	171673433	171673453	170816923	170816943	80875	hg19					enhancer	enh				GAGAACGAGGAAGCAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.459770243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6126	chr2	171673441	171673463	170816931	170816953	80876	hg19					enhancer	enh				GGAAGCAGCTGGAGGTGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.029923982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6127	chr2	171673442	171673463	170816932	170816953	80877	hg19					enhancer	enh				GAAGCAGCTGGAGGTGACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-1.495008233									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6128	chr2	171673460	171673482	170816950	170816972	80878	hg19					enhancer	enh				GCCGGGCAGATTACGCCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.307716401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6129	chr2	171673474	171673495	170816964	170816985	80879	hg19					enhancer	enh				GCCTGTCAGGGCCGAGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.299312937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6130	chr2	171673488	171673508	170816978	170816998	80880	hg19					enhancer	enh				GCCCAGCGATCCGCTCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	direct	Highly Significant	NA				0.404576102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6131	chr2	171673493	171673515	170816983	170817005	80881	hg19					enhancer	enh				GCACAGCGCCCAGCGATCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAD1	indirect	Non Significant	NA				-0.11399279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6132	chr2	172017246	172017267	171160736	171160757	80882	hg19					enhancer	enh				GCTCCGCCCGCGCTCCGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.199865194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6133	chr2	172017276	172017297	171160766	171160787	80883	hg19					enhancer	enh				GCCGGCCGAGGACACTTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.266477878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6134	chr2	172017276	172017296	171160766	171160786	80884	hg19					enhancer	enh				GCCGGCCGAGGACACTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.056860124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6135	chr2	172017296	172017317	171160786	171160807	80885	hg19					enhancer	enh				GGTGCCGGCAGGTTCCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.279249764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6136	chr2	172017296	172017316	171160786	171160806	80886	hg19					enhancer	enh				GTGCCGGCAGGTTCCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				0.035648386									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6137	chr2	172017308	172017330	171160798	171160820	80887	hg19					enhancer	enh				GACGCACTGCAGAGGTGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.411403098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6138	chr2	172017308	172017329	171160798	171160819	80888	hg19					enhancer	enh				GCCGGCACCTCTGCAGTGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.155138351									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6139	chr2	172017399	172017419	171160889	171160909	80889	hg19					enhancer	enh				GCCGCCTGTAACTGATGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.247504756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6140	chr2	172017401	172017421	171160891	171160911	80890	hg19					enhancer	enh				GCATCAGTTACAGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	direct	Highly Significant	NA				0.225389936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6141	chr2	172017435	172017456	171160925	171160946	80891	hg19					enhancer	enh				GCCTGTGCAAACACTATCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				0.106060719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6142	chr2	172017457	172017477	171160947	171160967	80892	hg19					enhancer	enh				GGCTCCTGCGCCTCCGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				-0.157388897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6143	chr2	172017464	172017484	171160954	171160974	80893	hg19					enhancer	enh				GCCGCCGCTACCGGAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TLK1	indirect	Non Significant	NA				0.003618406									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6144	chr2	172778779	172778799	171922269	171922289	80894	hg19					enhancer	enh				GCGGCTGACGGCATTCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	direct	Highly Significant	NA				0.225194347									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6145	chr2	172778816	172778838	171922306	171922328	80895	hg19					enhancer	enh				GCTAACGCCGAGAAGTCTGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				0.092016893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6146	chr2	172778932	172778954	171922422	171922444	80896	hg19					enhancer	enh				GACTGTGCGGTCACTTCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.118613725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6147	chr2	172778955	172778975	171922445	171922465	80897	hg19					enhancer	enh				GAATCAACCCGCGCGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	direct	Highly Significant	NA				0.643569998									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6148	chr2	172778956	172778978	171922446	171922468	80898	hg19					enhancer	enh				GACGAATCAACCCGCGCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	direct	Highly Significant	NA				0.376067866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6149	chr2	172778970	172778991	171922460	171922481	80899	hg19					enhancer	enh				GATTCGTCCTTCCTCAGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.352888936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6150	chr2	172778970	172778990	171922460	171922480	80900	hg19					enhancer	enh				GATTCGTCCTTCCTCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.035173247									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6151	chr2	172778984	172779006	171922474	171922496	80901	hg19					enhancer	enh				GAGCTACGATCACCCGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	direct	Highly Significant	NA				0.4905456									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6152	chr2	172778984	172779004	171922474	171922494	80902	hg19					enhancer	enh				GCTACGATCACCCGCGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.033136517									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6153	chr2	172778989	172779011	171922479	171922501	80903	hg19					enhancer	enh				GCGGGTGATCGTAGCTCGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.413085886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6154	chr2	172778991	172779011	171922481	171922501	80904	hg19					enhancer	enh				GGGTGATCGTAGCTCGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	direct	Highly Significant	NA				0.445476664									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6155	chr2	172778995	172779015	171922485	171922505	80905	hg19					enhancer	enh				GATCGTAGCTCGGAAATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				0.037633186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97012	chr2	172779021	172779043	171922511	171922533	80906	hg19	N/A	N/A	N/A	Enhatls103828	enhancer	enh				GTTACCGGGAAAAGTTTACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.43986694	HAT1	chr2	171922460	171983686	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8938
enhrx-97012	chr2	172779021	172779042	171922511	171922532	80907	hg19	N/A	N/A	N/A	Enhatls103828	enhancer	enh				GTTACCGGGAAAAGTTTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.233044536	HAT1	chr2	171922460	171983686	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8938
enhrx-97012	chr2	172779027	172779047	171922517	171922537	80908	hg19	N/A	N/A	N/A	Enhatls103828	enhancer	enh				GGGAAAAGTTTACCAAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.581259485	HAT1	chr2	171922460	171983686	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8938
enhrx-97012	chr2	172779059	172779081	171922549	171922571	80909	hg19	N/A	N/A	N/A	Enhatls103828	enhancer	enh				GATCGGGGATAGAACGCCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-1.47065371	HAT1	chr2	171922460	171983686	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8938
enhrx-97012	chr2	172779064	172779084	171922554	171922574	80910	hg19	N/A	N/A	N/A	Enhatls103828	enhancer	enh				GGGATAGAACGCCGAGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HAT1	indirect	Non Significant	NA				-0.028225319	HAT1	chr2	171922460	171983686	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	8938
enhrx-lit6156	chr2	172949327	172949349	172084599	172084621	80911	hg19					enhancer	enh				GCCCCGAGAGCGCGGCTCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.299432996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6157	chr2	172949337	172949357	172084609	172084629	80912	hg19					enhancer	enh				GCTCACTCGCCCCGAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.645085911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6158	chr2	172949355	172949375	172084627	172084647	80913	hg19					enhancer	enh				GCCCGGGGCTCTCCGCGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				0.168754858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6159	chr2	172949467	172949487	172084739	172084759	80914	hg19					enhancer	enh				GAACCCGCGCTTCTCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	direct	Highly Significant	NA				0.595580764									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6160	chr2	172949498	172949520	172084770	172084792	80915	hg19					enhancer	enh				GGTCTGATTAAAGCAGTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	direct	Highly Significant	NA				0.284999258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6161	chr2	172949498	172949519	172084770	172084791	80916	hg19					enhancer	enh				GTCTGATTAAAGCAGTGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				0.060346419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6162	chr2	172949522	172949544	172084794	172084816	80917	hg19					enhancer	enh				GCCACTCCAGCTCGAGGCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.283450162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6163	chr2	172949526	172949548	172084798	172084820	80918	hg19					enhancer	enh				GCCTCGAGCTGGAGTGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.032712982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6164	chr2	172949546	172949568	172084818	172084840	80919	hg19					enhancer	enh				GCTGGGCCTGGAGCAATGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				0.022980949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6165	chr2	172949549	172949569	172084821	172084841	80920	hg19					enhancer	enh				GGGCCTGGAGCAATGCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.515150675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6166	chr2	172949555	172949576	172084827	172084848	80921	hg19					enhancer	enh				GGAGCAATGCGAGCGGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.958554804									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6167	chr2	172949555	172949575	172084827	172084847	80922	hg19					enhancer	enh				GGGCCCGCTCGCATTGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.169833775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6168	chr2	172949556	172949576	172084828	172084848	80923	hg19					enhancer	enh				GAGCAATGCGAGCGGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.238814961									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6169	chr2	172949567	172949588	172084839	172084860	80924	hg19					enhancer	enh				GCGGGCCCCAGGGAGCGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				0.071697086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6170	chr2	172949576	172949598	172084848	172084870	80925	hg19					enhancer	enh				GCCAACGCCGCTGTCGCTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.010040213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6171	chr2	172949581	172949602	172084853	172084874	80926	hg19					enhancer	enh				GCGACAGCGGCGTTGGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				0.165604381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6172	chr2	172949630	172949650	172084902	172084922	80927	hg19					enhancer	enh				GCCCCTAAGCCCCGACTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	direct	Highly Significant	NA				0.324902557									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6173	chr2	172949651	172949671	172084923	172084943	80928	hg19					enhancer	enh				GGATGCGGCAGAGCGTACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	indirect	Non Significant	NA				-0.101798499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6174	chr2	172949680	172949700	172084952	172084972	80929	hg19					enhancer	enh				GGCCGGATAGGCGCTGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DLX1	direct	Highly Significant	NA				0.490398263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97120	chr2	174828417	174828437	173963689	173963709	80930	hg19	N/A	N/A	N/A	Enhatls103953	enhancer	enh				GGCAGGCGCGCCACGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.163556117	SP3	chr2	173900774	173965373	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9046
enhrx-97120	chr2	174828430	174828451	173963702	173963723	80931	hg19	N/A	N/A	N/A	Enhatls103953	enhancer	enh				GCGCCCGCCATCCCGGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.194611935	SP3	chr2	173900774	173965373	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9046
enhrx-97120	chr2	174828473	174828493	173963745	173963765	80932	hg19	N/A	N/A	N/A	Enhatls103953	enhancer	enh				GCGCGCGGGACTTACCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.421476851	SP3	chr2	173900774	173965373	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9046
enhrx-97120	chr2	174828479	174828499	173963751	173963771	80933	hg19	N/A	N/A	N/A	Enhatls103953	enhancer	enh				GGGACTTACCGCTCCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.84111797	SP3	chr2	173900774	173965373	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9046
enhrx-lit6175	chr2	174828512	174828533	173963784	173963805	80934	hg19					enhancer	enh				GAGGAGGCGGCCGCCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.056928038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6176	chr2	174828525	174828545	173963797	173963817	80935	hg19					enhancer	enh				GCCTCCTCCTCGTCGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.767311978									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6177	chr2	174828535	174828555	173963807	173963827	80936	hg19					enhancer	enh				GCCATCGCCGGGCGACGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.968422342									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6178	chr2	174828546	174828568	173963818	173963840	80937	hg19					enhancer	enh				GCAAGATAGGGCCGCCATCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.905397954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6179	chr2	174828547	174828568	173963819	173963840	80938	hg19					enhancer	enh				GCAAGATAGGGCCGCCATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.036446409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6180	chr2	174828572	174828593	173963844	173963865	80939	hg19					enhancer	enh				GGTAGCGGCCAGCAGAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.804332516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6181	chr2	174828573	174828593	173963845	173963865	80940	hg19					enhancer	enh				GTAGCGGCCAGCAGAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.066659343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6182	chr2	174828578	174828599	173963850	173963871	80941	hg19					enhancer	enh				GGCCAGCAGAGCGAGCGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.179981282									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6183	chr2	174828579	174828599	173963851	173963871	80942	hg19					enhancer	enh				GCCAGCAGAGCGAGCGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-2.171299506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6184	chr2	174828583	174828603	173963855	173963875	80943	hg19					enhancer	enh				GCCGTCACCGCTCGCTCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.904945033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6185	chr2	174828624	174828644	173963896	173963916	80944	hg19					enhancer	enh				GCGGGTTCAGAGAGGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.877313077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6186	chr2	174828666	174828686	173963938	173963958	80945	hg19					enhancer	enh				GGTCGGGCCGCCTTTCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-1.51331845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6187	chr2	174828679	174828700	173963951	173963972	80946	hg19					enhancer	enh				GAGTCGTACTTCCTGTGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.807166966									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6188	chr2	174828706	174828728	173963978	173964000	80947	hg19					enhancer	enh				GCTTGCCCGGGCGCAGTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.952697179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6189	chr2	174828711	174828731	173963983	173964003	80948	hg19					enhancer	enh				GGCGCTTGCCCGGGCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP3	indirect	Non Significant	NA				-0.889506569									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97130	chr2	175113158	175113179	174248430	174248451	80949	hg19	N/A	N/A	N/A	Enhatls103964	enhancer	enh				GTGAGGCCCTCAGGGAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.810134724	OLA1	chr2	174072446	174248599	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9056
enhrx-97130	chr2	175113168	175113189	174248440	174248461	80950	hg19	N/A	N/A	N/A	Enhatls103964	enhancer	enh				GCCGAGCACGGTGAGGCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.007722801	OLA1	chr2	174072446	174248599	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9056
enhrx-lit6190	chr2	175113181	175113201	174248453	174248473	80951	hg19					enhancer	enh				GTCATCGCCCAGGCCGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.515573097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6191	chr2	175113191	175113211	174248463	174248483	80952	hg19					enhancer	enh				GGGACCCCGTGTCATCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-4.700212809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6192	chr2	175113205	175113227	174248477	174248499	80953	hg19					enhancer	enh				GGTCCCAGCGGCAGCGAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.221792634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6193	chr2	175113206	175113227	174248478	174248499	80954	hg19					enhancer	enh				GTCCCAGCGGCAGCGAGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.558168619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6194	chr2	175113211	175113232	174248483	174248504	80955	hg19					enhancer	enh				GACCTTTCTCTCGCTGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-0.206278214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6195	chr2	175113212	175113232	174248484	174248504	80956	hg19					enhancer	enh				GACCTTTCTCTCGCTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-0.246499176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6196	chr2	175113222	175113243	174248494	174248515	80957	hg19					enhancer	enh				GAGAAAGGTCCTGCCGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				0.002239848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6197	chr2	175113224	175113246	174248496	174248518	80958	hg19					enhancer	enh				GAAAGGTCCTGCCGGCAGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-1.001511876									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6198	chr2	175113229	175113251	174248501	174248523	80959	hg19					enhancer	enh				GTCCTGCCGGCAGCTGGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-1.652263657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6199	chr2	175113229	175113250	174248501	174248522	80960	hg19					enhancer	enh				GTCCTGCCGGCAGCTGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-1.232641911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6200	chr2	175113274	175113294	174248546	174248566	80961	hg19					enhancer	enh				GGCCCGTCCCCTCCGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-1.28205125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6201	chr2	175113288	175113309	174248560	174248581	80962	hg19					enhancer	enh				GCCGAGCGGCACGCACGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-0.799952866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6202	chr2	175113292	175113313	174248564	174248585	80963	hg19					enhancer	enh				GCCGCCGTCGTGCGTGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-2.195451834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6203	chr2	175113402	175113423	174248674	174248695	80964	hg19					enhancer	enh				GCCCATTGGCCTAACCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OLA1	indirect	Non Significant	NA				-0.074846747									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97132	chr2	175188750	175188770	174324022	174324042	80965	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGAGATTTGCCTCAAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.032133863	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188756	175188776	174324028	174324048	80966	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTTGCCTCAAAATAAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216318253	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188757	175188777	174324029	174324049	80967	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGCCTCAAAATAAGGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.054129997	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188768	175188788	174324040	174324060	80968	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAAGGAAGAGGGAAATGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05770846	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188789	175188809	174324061	174324081	80969	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGATAGAGATGAAACAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371476708	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188815	175188835	174324087	174324107	80970	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGTCAACAGTTGTCAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.073846926	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188816	175188836	174324088	174324108	80971	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGACAACTGTTGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.33967968	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188817	175188837	174324089	174324109	80972	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGACAACTGTTGACACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036773499	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188823	175188843	174324095	174324115	80973	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAACTGTTGACACTGGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050196366	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188832	175188852	174324104	174324124	80974	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACACTGGGTGATGGAGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.369592317	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188833	175188853	174324105	174324125	80975	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACTGGGTGATGGAGATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176384457	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175188834	175188854	174324106	174324126	80976	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACTGGGTGATGGAGATAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195128874	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189036	175189056	174324308	174324328	80977	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCATGGTTGTGTGTGCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.165909538	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189227	175189247	174324499	174324519	80978	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGATATCAGTAAGACTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.547493466	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189243	175189263	174324515	174324535	80979	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACCTGGTAAGATTATTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.079977396	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189248	175189268	174324520	174324540	80980	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATCCACACAATAATCTTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.034763059	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189355	175189375	174324627	174324647	80981	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGGCCTCCTCTTCCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.320068547	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189362	175189382	174324634	174324654	80982	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCTCCAGGAGGGGAAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.781600633	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189365	175189385	174324637	174324657	80983	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAGTTCTCCAGGAGGGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.988982886	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189371	175189391	174324643	174324663	80984	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTTCATAGTTCTCCAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.412766235	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189372	175189392	174324644	174324664	80985	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTTCATAGTTCTCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.144171035	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189373	175189393	174324645	174324665	80986	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCTTTCATAGTTCTCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.116558114	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189388	175189408	174324660	174324680	80987	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCCAGACCATGAAATGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.52911271	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189394	175189414	174324666	174324686	80988	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCCACACATTTCATGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.203249713	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189396	175189416	174324668	174324688	80989	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCATGAAATGTGTGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.749753551	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189399	175189419	174324671	174324691	80990	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGTCAGCCACACATTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375123718	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189426	175189446	174324698	174324718	80991	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACCTTACTCCTTCCAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119731636	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189431	175189451	174324703	174324723	80992	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCCTGATTTGGAAGGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.47971636	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189436	175189456	174324708	174324728	80993	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCCAAATCAGGCAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.128951868	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189438	175189458	174324710	174324730	80994	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGCAGCTGCCTGATTTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.109545944	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189442	175189462	174324714	174324734	80995	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCCTGCAGCTGCCTGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.827049447	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189478	175189498	174324750	174324770	80996	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTACAGAAGCAAGGTTGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104245774	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189484	175189504	174324756	174324776	80997	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTAGTACAGAAGCAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.284295855	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189488	175189508	174324760	174324780	80998	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGGGCCTAGTACAGAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.773576269	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189506	175189526	174324778	174324798	80999	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGTGTGTGTGGGAAGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.056084936	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189507	175189527	174324779	174324799	81000	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTGTGTGTGTGGGAAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.125279039	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189562	175189582	174324834	174324854	81001	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAAACTTACTGTGAAACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.810985212	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189582	175189602	174324854	174324874	81002	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGGGAATGTTATTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.285588227	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189589	175189609	174324861	174324881	81003	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATGTTATTTCAGTGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.370692553	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189593	175189613	174324865	174324885	81004	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTATTTCAGTGGAAAATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.061191375	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189629	175189649	174324901	174324921	81005	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTCAACTATTAATAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.709308674	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189643	175189663	174324915	174324935	81006	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAAGTATGGAGCACATTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.13186642	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189675	175189695	174324947	174324967	81007	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGGTTAAATAAAACTATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207214038	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189739	175189759	174325011	174325031	81008	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGAAGGAAACACAAGTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091480605	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189750	175189770	174325022	174325042	81009	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAGTTTCAAGGCCCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.397165079	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189757	175189777	174325029	174325049	81010	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAGGCCCGCCCAAGGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.154274359	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189758	175189778	174325030	174325050	81011	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGGCCCGCCCAAGGTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.650186921	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189766	175189786	174325038	174325058	81012	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAAGGCCCTGTGACCTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.598312272	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189768	175189788	174325040	174325060	81013	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAGGTCACAGGGCCTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.243748832	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189769	175189789	174325041	174325061	81014	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACTTAAGGCCCTGTGACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.41098838	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189770	175189790	174325042	174325062	81015	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACTTAAGGCCCTGTGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075466908	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189771	175189791	174325043	174325063	81016	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTCACAGGGCCTTAAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020194393	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189772	175189792	174325044	174325064	81017	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCACAGGGCCTTAAGTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.05323181	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189782	175189802	174325054	174325074	81018	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTAAGTGGTGGGCCTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.241603462	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189784	175189804	174325056	174325076	81019	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACTTAAGGCCCACCACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.594739206	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189785	175189805	174325057	174325077	81020	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGTGGTGGGCCTTAAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.215129109	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189786	175189806	174325058	174325078	81021	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTGGTGGGCCTTAAGTGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.010700841	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189798	175189818	174325070	174325090	81022	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATTAAGGCCCACCACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.269720041	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189812	175189832	174325084	174325104	81023	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGGAGGTGGGTGTGAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.177742925	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189822	175189842	174325094	174325114	81024	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCACCTCCTGAGACCTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.392757794	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189823	175189843	174325095	174325115	81025	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACCTCCTGAGACCTCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.027839667	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189824	175189844	174325096	174325116	81026	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTTGGAGGTCTCAGGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.504759957	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189825	175189845	174325097	174325117	81027	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTTTGGAGGTCTCAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.99062527	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189831	175189851	174325103	174325123	81028	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACAAGCCCTTTGGAGGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.517277355	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189838	175189858	174325110	174325130	81029	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTAAGCACAAGCCCTTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23171909	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189839	175189859	174325111	174325131	81030	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAAGGGCTTGTGCTTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284554286	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189841	175189861	174325113	174325133	81031	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGGGTAAGCACAAGCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05722766	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189859	175189879	174325131	174325151	81032	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGATAGCTAGGGCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.519378396	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189860	175189880	174325132	174325152	81033	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGATAGCTAGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.278726774	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189867	175189887	174325139	174325159	81034	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCAACAGAGCTGATAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.900007131	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189868	175189888	174325140	174325160	81035	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCAACAGAGCTGATAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.260795345	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189911	175189931	174325183	174325203	81036	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAACAACTGCCATCCAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033271399	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175189943	175189963	174325215	174325235	81037	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCATTCCTAATCAAAAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032186853	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190274	175190294	174325546	174325566	81038	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCTACAAGACAGATAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.103571523	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190278	175190298	174325550	174325570	81039	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTATCTGTCTTGTAGAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.189081128	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190309	175190329	174325581	174325601	81040	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTTGCAGCCCAGCGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.440392526	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190320	175190340	174325592	174325612	81041	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGGGCAGACCTCTTACCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.087741896	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190321	175190341	174325593	174325613	81042	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGGGCAGACCTCTTACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.291966666	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190327	175190347	174325599	174325619	81043	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGAGGTCTGCCCAACTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.011698971	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190338	175190358	174325610	174325630	81044	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAACTGATGAGGAGAGTTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.319799881	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190340	175190360	174325612	174325632	81045	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGTAACTCTCCTCATCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025294191	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190343	175190363	174325615	174325635	81046	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATGAGGAGAGTTACAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198930902	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190344	175190364	174325616	174325636	81047	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATGAGGAGAGTTACAGGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.215220806	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190355	175190375	174325627	174325647	81048	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTACAGGCTTGGGAGTAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.549949598	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190359	175190379	174325631	174325651	81049	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCTTGGGAGTAGCTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.54476013	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190360	175190380	174325632	174325652	81050	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTGGGAGTAGCTTGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009156985	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190366	175190386	174325638	174325658	81051	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTAGCTTGGGCCGGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.804479594	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190367	175190387	174325639	174325659	81052	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTAGCTTGGGCCGGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.621684161	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190381	175190401	174325653	174325673	81053	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCAGAGCCTCCCCTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.014121004	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190440	175190460	174325712	174325732	81054	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGAAATGAAACACAAATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.097637838	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190460	175190480	174325732	174325752	81055	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACAGCATTTGGAACAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225868366	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190461	175190481	174325733	174325753	81056	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGAACAGCATTTGGAACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225737531	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190462	175190482	174325734	174325754	81057	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGAACAGCATTTGGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.226376096	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190463	175190483	174325735	174325755	81058	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGAACAGCATTTGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.341303846	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190466	175190486	174325738	174325758	81059	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCAAATGCTGTTCAACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.468884676	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190467	175190487	174325739	174325759	81060	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAAATGCTGTTCAACTTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216217113	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190470	175190490	174325742	174325762	81061	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCTTAAGTTGAACAGCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048168144	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190552	175190572	174325824	174325844	81062	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGCTGCCATCAAATACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045380812	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190553	175190573	174325825	174325845	81063	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCTGCCATCAAATACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.098021471	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190555	175190575	174325827	174325847	81064	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTTGGTATTTGATGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145299437	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190562	175190582	174325834	174325854	81065	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAAGGGCCCTTGGTATTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.078251347	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190572	175190592	174325844	174325864	81066	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTTTGAATATAAGGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.065583927	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190579	175190599	174325851	174325871	81067	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCTGAAGTTTGAATATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.598531301	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190580	175190600	174325852	174325872	81068	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACAGCTGAAGTTTGAATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119143336	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190601	175190621	174325873	174325893	81069	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATTTAGTTGGGAGGTTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378457394	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190654	175190674	174325926	174325946	81070	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATCCTGCTTACATAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007179261	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190670	175190690	174325942	174325962	81071	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCCGGACAATTCCATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.213965717	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190671	175190691	174325943	174325963	81072	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCCGGACAATTCCATGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.628795979	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190672	175190692	174325944	174325964	81073	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGGACAATTCCATGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.371525627	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190673	175190693	174325945	174325965	81074	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGGACAATTCCATGCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200750218	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190674	175190694	174325946	174325966	81075	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGGACAATTCCATGCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06829944	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190676	175190696	174325948	174325968	81076	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCCTTGCATGGAATTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.130566148	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190681	175190701	174325953	174325973	81077	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCCATGCAAGGGGGGTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.588019777	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190686	175190706	174325958	174325978	81078	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACCAGACACCCCCCTTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047706798	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190700	175190720	174325972	174325992	81079	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGGTTACAACTGAAGTTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.175668321	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190729	175190749	174326001	174326021	81080	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACGTCCGACTTGTCCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.432110873	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190736	175190756	174326008	174326028	81081	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCTCCATTCCCGGACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167931995	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190797	175190817	174326069	174326089	81082	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTTGCCGAAAGAGAAGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.282258607	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190805	175190825	174326077	174326097	81083	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCGCCAACACTTCTCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.383188853	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190813	175190833	174326085	174326105	81084	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGTTGGCGCCTCAAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05513904	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190825	175190845	174326097	174326117	81085	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCTGATCCTCAAGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139067044	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190826	175190846	174326098	174326118	81086	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAACTTGAGGATCAGCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.433003328	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190827	175190847	174326099	174326119	81087	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACTTGAGGATCAGCTTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.01289125	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190839	175190859	174326111	174326131	81088	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTTCTTGGGCCCCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.401452074	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190840	175190860	174326112	174326132	81089	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCTTGGGCCCCACTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000515142	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190848	175190868	174326120	174326140	81090	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCCCCACTCCAGGGTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.01045891	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190849	175190869	174326121	174326141	81091	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCACTCCAGGGTGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.564459451	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190850	175190870	174326122	174326142	81092	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCACTCCAGGGTGTCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.109720488	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190851	175190871	174326123	174326143	81093	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCACTCCAGGGTGTCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.461490239	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190853	175190873	174326125	174326145	81094	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCGCGACACCCTGGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.699822996	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190854	175190874	174326126	174326146	81095	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCCGCGACACCCTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301113812	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190855	175190875	174326127	174326147	81096	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACCCCCGCGACACCCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.334034328	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190860	175190880	174326132	174326152	81097	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACCCGACCCCCGCGACACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.657179977	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190888	175190908	174326160	174326180	81098	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGAATCTTTCGGGGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253506146	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190891	175190911	174326163	174326183	81099	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGAGAATCTTTCGGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029320844	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190895	175190915	174326167	174326187	81100	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTAGCTGAGAATCTTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.106212748	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190896	175190916	174326168	174326188	81101	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTTAGCTGAGAATCTTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.981239855	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190897	175190917	174326169	174326189	81102	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGTTAGCTGAGAATCTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.067557851	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190898	175190918	174326170	174326190	81103	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGGTTAGCTGAGAATCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.226764689	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190916	175190936	174326188	174326208	81104	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTTCCCCGCCGAGACCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.008804265	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190917	175190937	174326189	174326209	81105	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCTTGGTCTCGGCGGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.550893856	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190918	175190938	174326190	174326210	81106	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCTTGGTCTCGGCGGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.735144062	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190923	175190943	174326195	174326215	81107	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGGCCTCTTGGTCTCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.399223974	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190924	175190944	174326196	174326216	81108	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGGCCTCTTGGTCTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.042425456	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190925	175190945	174326197	174326217	81109	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGAGGGCCTCTTGGTCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.355535749	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190928	175190948	174326200	174326220	81110	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTGAGGGCCTCTTGGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.410174047	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190934	175190954	174326206	174326226	81111	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGTCAGAGTGAGGGCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023510335	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190939	175190959	174326211	174326231	81112	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCTCACTCTGACACCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.195683577	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190940	175190960	174326212	174326232	81113	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTCACTCTGACACCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257642041	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190942	175190962	174326214	174326234	81114	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGGAGTGGTGTCAGAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196073655	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190943	175190963	174326215	174326235	81115	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCGGAGTGGTGTCAGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.385850313	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190956	175190976	174326228	174326248	81116	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGTAGCTTGGCTCCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.198136034	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190958	175190978	174326230	174326250	81117	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGGGAGCCAAGCTACTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.00574036	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190961	175190981	174326233	174326253	81118	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTTACAGTAGCTTGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.249774335	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190968	175190988	174326240	174326260	81119	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATCAGCTCCTTACAGTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.254187995	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175190980	175191000	174326252	174326272	81120	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCTGATACCACCCCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.601986632	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191037	175191057	174326309	174326329	81121	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGTCAGGGATTCGCAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000936518	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191038	175191058	174326310	174326330	81122	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACGTCAGGGATTCGCAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.259107171	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191039	175191059	174326311	174326331	81123	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACGTCAGGGATTCGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.537521504	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191040	175191060	174326312	174326332	81124	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACGTCAGGGATTCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.412965054	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191045	175191065	174326317	174326337	81125	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATCCCTGACGTTCTAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284721686	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191051	175191071	174326323	174326343	81126	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGACGTTCTAGCCCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409635184	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191052	175191072	174326324	174326344	81127	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCGCCGGGCTAGAACGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.359277917	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191053	175191073	174326325	174326345	81128	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCGCCGGGCTAGAACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.548609795	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191066	175191086	174326338	174326358	81129	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCGAAGGTCCTCTTAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.065142546	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191066	175191086	174326338	174326358	81130	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATTTAAGAGGACCTTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.957875148	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191067	175191087	174326339	174326359	81131	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAATTTAAGAGGACCTTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.802940342	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191125	175191145	174326397	174326417	81132	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGATTGGGCGCGCAGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.360797112	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191125	175191145	174326397	174326417	81133	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCTCTGCGCGCCCAATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.401478303	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191126	175191146	174326398	174326418	81134	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACGATTGGGCGCGCAGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.497155504	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191126	175191146	174326398	174326418	81135	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCTCTGCGCGCCCAATCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.059257053	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191134	175191154	174326406	174326426	81136	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCCCAATCGTGGGATTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104244834	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191135	175191155	174326407	174326427	81137	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCCCAATCGTGGGATTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.344050868	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191140	175191160	174326412	174326432	81138	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCCAAGAATCCCACGATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207280657	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191141	175191161	174326413	174326433	81139	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACTCCCAAGAATCCCACGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.506766812	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191147	175191167	174326419	174326439	81140	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGATTCTTGGGAGTTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.475263366	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191148	175191168	174326420	174326440	81141	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATTCTTGGGAGTTCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.180740236	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191153	175191173	174326425	174326445	81142	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGGGAGTTCCCCGCGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.249779623	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191165	175191185	174326437	174326457	81143	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCAGACTTCCTTGCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.519548949	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191166	175191186	174326438	174326458	81144	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCAGACTTCCTTGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.131469956	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191167	175191187	174326439	174326459	81145	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCAGACTTCCTTGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019152111	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191179	175191199	174326451	174326471	81146	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCTGCTGCTCCCCGCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.019237614	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191182	175191202	174326454	174326474	81147	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGCTCCCCGCAGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.247862569	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191187	175191207	174326459	174326479	81148	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCCCGCAGCTGCGGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.206033638	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191191	175191211	174326463	174326483	81149	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCTCTCCTCCGCAGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.400706859	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191192	175191212	174326464	174326484	81150	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCTCTCCTCCGCAGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216138391	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191193	175191213	174326465	174326485	81151	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTCCTCTCCTCCGCAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.066641451	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191206	175191226	174326478	174326498	81152	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGAGGGAGCCTGCGTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11752517	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191212	175191232	174326484	174326504	81153	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAGCCTGCGTGCTGGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.016722561	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191219	175191239	174326491	174326511	81154	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACACCCTGCCCCAGCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284062626	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191226	175191246	174326498	174326518	81155	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGGCAGGGTGTCGCGAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108588571	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191227	175191247	174326499	174326519	81156	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGCAGGGTGTCGCGAACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025672137	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191228	175191248	174326500	174326520	81157	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCAGGGTGTCGCGAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				6.61226E-05	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191271	175191291	174326543	174326563	81158	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCCGCTTTCCCGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.066929156	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191272	175191292	174326544	174326564	81159	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCCGCTTTCCCGCCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286479569	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191273	175191293	174326545	174326565	81160	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCGCTTTCCCGCCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.361948506	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191276	175191296	174326548	174326568	81161	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCCGGCAGGCGGGAAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158822597	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191277	175191297	174326549	174326569	81162	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCCCGGCAGGCGGGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101522758	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191278	175191298	174326550	174326570	81163	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCCCGGCAGGCGGGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.418971039	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191285	175191305	174326557	174326577	81164	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCGGCAGGTCCCCGGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.776298968	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191286	175191306	174326558	174326578	81165	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCGGCAGGTCCCCGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.691297318	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191288	175191308	174326560	174326580	81166	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCCGGGGACCTGCCGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.735989861	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191289	175191309	174326561	174326581	81167	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGTTCGGCAGGTCCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254187045	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191293	175191313	174326565	174326585	81168	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCCGCGTTCGGCAGGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.274716916	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191300	175191320	174326572	174326592	81169	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGGTGGTTCCGCGTTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04008955	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191304	175191324	174326576	174326596	81170	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGGAGGGTGGTTCCGCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.842409839	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191308	175191328	174326580	174326600	81171	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGGAACCACCCTCCTTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09069214	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191316	175191336	174326588	174326608	81172	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATTTGCCTCAGGAAGGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.584623306	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191317	175191337	174326589	174326609	81173	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTCCTTCCTGAGGCAAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142666605	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191318	175191338	174326590	174326610	81174	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCTTCCTGAGGCAAATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126152883	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191319	175191339	174326591	174326611	81175	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAATTTGCCTCAGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.630171497	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191320	175191340	174326592	174326612	81176	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAAATTTGCCTCAGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.240761707	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191321	175191341	174326593	174326613	81177	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCCTGAGGCAAATTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.939946884	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191322	175191342	174326594	174326614	81178	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCCTGAGGCAAATTTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.5345057	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191323	175191343	174326595	174326615	81179	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCCAAATTTGCCTCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.029794308	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191323	175191343	174326595	174326615	81180	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCTGAGGCAAATTTGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.657952263	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191327	175191347	174326599	174326619	81181	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCCCTCCCAAATTTGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.248314122	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191348	175191368	174326620	174326640	81182	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGTCCAGAAGCTGTAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.802513731	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191349	175191369	174326621	174326641	81183	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTCCAGAAGCTGTAGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.558743767	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191350	175191370	174326622	174326642	81184	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCAGAAGCTGTAGAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310125968	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191355	175191375	174326627	174326647	81185	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCCCCGACTCTACAGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.220469001	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191377	175191397	174326649	174326669	81186	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCGCCAGATTCTGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207809738	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191378	175191398	174326650	174326670	81187	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCGGCAGAATCTGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153403461	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191384	175191404	174326656	174326676	81188	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGATTCTGCCGCTCGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.163660121	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191385	175191405	174326657	174326677	81189	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATTCTGCCGCTCGGAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007896951	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191385	175191405	174326657	174326677	81190	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAACTTCCGAGCGGCAGAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.74575262	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191386	175191406	174326658	174326678	81191	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATTCTGCCGCTCGGAAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.599478527	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191387	175191407	174326659	174326679	81192	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCTGCCGCTCGGAAGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.672118999	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191395	175191415	174326667	174326687	81193	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACTGCCCCCAACTTCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.241586291	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191409	175191429	174326681	174326701	81194	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGTCCCCAGTCCCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.046187142	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191425	175191445	174326697	174326717	81195	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTCAGGCCCCCGCGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.578034604	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191426	175191446	174326698	174326718	81196	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCAGGCCCCCGCGCTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.001532255	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191435	175191455	174326707	174326727	81197	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAGCGCCCTGTGAGCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02251805	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191436	175191456	174326708	174326728	81198	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGGAGCGCCCTGTGAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.269883686	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191437	175191457	174326709	174326729	81199	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGGAGCGCCCTGTGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116327312	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191438	175191458	174326710	174326730	81200	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCGGAGCGCCCTGTGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104600548	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191439	175191459	174326711	174326731	81201	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCACAGGGCGCTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.857761237	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191440	175191460	174326712	174326732	81202	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCACAGGGCGCTCCGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.809998408	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191446	175191466	174326718	174326738	81203	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGCGCTCCGCCGAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224697195	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191451	175191471	174326723	174326743	81204	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCGCCGAGGGCGCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.189100461	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191459	175191479	174326731	174326751	81205	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCGCCTGGCCCGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085525842	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191472	175191492	174326744	174326764	81206	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGGAGGTGACACCGCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.740180019	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191489	175191509	174326761	174326781	81207	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAAGTAAATGACTTCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.267171039	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191492	175191512	174326764	174326784	81208	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGGCAAGTAAATGACTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.444148377	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191494	175191514	174326766	174326786	81209	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGTCATTTACTTGCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.506870958	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191500	175191520	174326772	174326792	81210	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTTACTTGCCCTGAAGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00017256	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191511	175191531	174326783	174326803	81211	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCGAGGGCCAGCTCCTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045710903	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191512	175191532	174326784	174326804	81212	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTCGAGGGCCAGCTCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.741286743	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191515	175191535	174326787	174326807	81213	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAGCTGGCCCTCGACCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07777122	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191518	175191538	174326790	174326810	81214	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGGCCCTCGACCCCTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.218911761	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191522	175191542	174326794	174326814	81215	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCTCGACCCCTTGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149048104	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191526	175191546	174326798	174326818	81216	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCATCCTCCAAGGGGTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.224411248	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191527	175191547	174326799	174326819	81217	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCATCCTCCAAGGGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.029762106	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191533	175191553	174326805	174326825	81218	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGAATCTCCATCCTCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167554303	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191534	175191554	174326806	174326826	81219	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGAATCTCCATCCTCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.321657286	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191535	175191555	174326807	174326827	81220	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAGGAATCTCCATCCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.071088502	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191561	175191581	174326833	174326853	81221	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCCTCCGCCTCCCCCAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.143540297	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191569	175191589	174326841	174326861	81222	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCGCCGACCTGGGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.155734641	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191572	175191592	174326844	174326864	81223	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCTCTTCGCCGACCTGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.317605783	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191574	175191594	174326846	174326866	81224	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCAGGTCGGCGAAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002277955	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191575	175191595	174326847	174326867	81225	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACGTCTCTTCGCCGACCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086822618	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191576	175191596	174326848	174326868	81226	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACGTCTCTTCGCCGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.206057947	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191577	175191597	174326849	174326869	81227	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCACGTCTCTTCGCCGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262821571	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191578	175191598	174326850	174326870	81228	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCACGTCTCTTCGCCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083534814	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191585	175191605	174326857	174326877	81229	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGAGACGTGGAATTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.278519385	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191612	175191632	174326884	174326904	81230	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTACAGAGCTCGCGGAATCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.24131087	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191621	175191641	174326893	174326913	81231	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCATAATTACAGAGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.393104361	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191654	175191674	174326926	174326946	81232	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCACCGTTGACTTAAGTTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.098170211	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191659	175191679	174326931	174326951	81233	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGCCAAGTAACTTAAGTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.444066372	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191664	175191684	174326936	174326956	81234	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTAAGTTACTTGGCGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.042077434	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191665	175191685	174326937	174326957	81235	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAAGTTACTTGGCGCTGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.555329361	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191669	175191689	174326941	174326961	81236	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTACTTGGCGCTGCGAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.155230013	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191670	175191690	174326942	174326962	81237	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTACTTGGCGCTGCGAGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033452164	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191671	175191691	174326943	174326963	81238	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACTTGGCGCTGCGAGGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.587045213	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191697	175191717	174326969	174326989	81239	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGCATTTAATCAATATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159587773	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191698	175191718	174326970	174326990	81240	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGCATTTAATCAATATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.131891966	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191755	175191775	174327027	174327047	81241	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGTTCACTTGATCACAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.334981195	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191756	175191776	174327028	174327048	81242	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCACTTGATCACAATAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1288728	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191770	175191790	174327042	174327062	81243	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAATAATGGGATTGACAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.805996751	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191771	175191791	174327043	174327063	81244	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GATAATGGGATTGACAATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125329893	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191772	175191792	174327044	174327064	81245	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTAATGGGATTGACAATTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.550193757	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191794	175191814	174327066	174327086	81246	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAATGCATCCCAGATGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.242360094	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191803	175191823	174327075	174327095	81247	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCAGATGTAGCGGAACCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.817463595	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191804	175191824	174327076	174327096	81248	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGATGTAGCGGAACCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.170251837	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191806	175191826	174327078	174327098	81249	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCATAGGTTCCGCTACATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24044635	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191807	175191827	174327079	174327099	81250	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCATAGGTTCCGCTACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.176477578	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191818	175191838	174327090	174327110	81251	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACCTATGGGCTGCGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.377154773	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191822	175191842	174327094	174327114	81252	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTGCTGCACGCAGCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115664492	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191825	175191845	174327097	174327117	81253	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCTGCGTGCAGCAGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.505677209	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191838	175191858	174327110	174327130	81254	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCAGAGGGCTTCTCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169506358	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191839	175191859	174327111	174327131	81255	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCAGAGGGCTTCTCAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.175405423	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191840	175191860	174327112	174327132	81256	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGAGGGCTTCTCAGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.537521974	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191846	175191866	174327118	174327138	81257	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGCTTCTCAGAGAGGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.118050504	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191847	175191867	174327119	174327139	81258	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTCTCAGAGAGGGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.072377021	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191890	175191910	174327162	174327182	81259	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCAGAGCAGGAAGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.215971192	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191901	175191921	174327173	174327193	81260	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCAGCGCGGAAGCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.535180595	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191902	175191922	174327174	174327194	81261	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCAGCGCGGAAGCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.457281249	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191905	175191925	174327177	174327197	81262	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCGCGGAAGCACAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.301492877	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191912	175191932	174327184	174327204	81263	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCACAGCGGGAGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.583126116	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191933	175191953	174327205	174327225	81264	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGGACGCCCAGCCTCGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.569467735	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191940	175191960	174327212	174327232	81265	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCAGCCTCGTCAAGGTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082343707	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191943	175191963	174327215	174327235	81266	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGAAGACCTTGACGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.667874512	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191944	175191964	174327216	174327236	81267	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGAAGACCTTGACGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233732681	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191948	175191968	174327220	174327240	81268	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTGGCCGAAGACCTTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.433635007	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191953	175191973	174327225	174327245	81269	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGTCTTCGGCCACCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151485065	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191954	175191974	174327226	174327246	81270	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGTCTTCGGCCACCCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.621521949	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191966	175191986	174327238	174327258	81271	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTCGAGCCTCCCGGGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.245019713	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191968	175191988	174327240	174327260	81272	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGCCCGGGAGGCTCGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.395862538	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191969	175191989	174327241	174327261	81273	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGTTTCGAGCCTCCCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.497603788	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191970	175191990	174327242	174327262	81274	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGTTTCGAGCCTCCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.157560819	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191971	175191991	174327243	174327263	81275	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGTTTCGAGCCTCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.091340525	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191974	175191994	174327246	174327266	81276	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCCAGTTTCGAGCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.666047754	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191974	175191994	174327246	174327266	81277	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGGAGGCTCGAAACTGGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.256462982	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191975	175191995	174327247	174327267	81278	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAGGCTCGAAACTGGCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.085141539	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191975	175191995	174327247	174327267	81279	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAAGCCAGTTTCGAGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.186936584	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175191976	175191996	174327248	174327268	81280	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCTCGAAACTGGCTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.485191484	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192000	175192020	174327272	174327292	81281	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACCTGAATGCCTCGACTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.001263306	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192001	175192021	174327273	174327293	81282	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCTGAATGCCTCGACTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373645773	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192004	175192024	174327276	174327296	81283	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCCTGGGAGTCGAGGCATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.027732279	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192010	175192030	174327282	174327302	81284	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCGACTCCCAGGGAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.415815981	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192011	175192031	174327283	174327303	81285	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCGACTCCCAGGGAGACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.349648498	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192012	175192032	174327284	174327304	81286	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGATGTCTCCCTGGGAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.03009663	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192018	175192038	174327290	174327310	81287	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGGGAGACATCGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.517890384	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192020	175192040	174327292	174327312	81288	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGAGCTCCCGATGTCTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.356836256	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192021	175192041	174327293	174327313	81289	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGAGCTCCCGATGTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102718728	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192035	175192055	174327307	174327327	81290	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCGGAGCCACTCTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.055301575	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192041	175192061	174327313	174327333	81291	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGCCACTCTCCCTGTGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.038528339	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192046	175192066	174327318	174327338	81292	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGCCATCGCCACAGGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.402897353	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192053	175192073	174327325	174327345	81293	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCAGGTGCCATCGCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.378770927	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192054	175192074	174327326	174327346	81294	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAGGCAGGTGCCATCGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048572899	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192055	175192075	174327327	174327347	81295	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTGGCGATGGCACCTGCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04076558	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192069	175192089	174327341	174327361	81296	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GAAGCGAGACGGCCTTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.485417252	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192073	175192093	174327345	174327365	81297	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCAGCAAGCGAGACGGCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043642809	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192078	175192098	174327350	174327370	81298	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCGTCTCGCTTGCTGATGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085065914	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192081	175192101	174327353	174327373	81299	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCCAGGCATCAGCAAGCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.373520865	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192082	175192102	174327354	174327374	81300	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTCGCTTGCTGATGCCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.058624395	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192083	175192103	174327355	174327375	81301	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCGCTTGCTGATGCCTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.25623927	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192087	175192107	174327359	174327379	81302	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTTGCTGATGCCTGGCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.653701334	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192090	175192110	174327362	174327382	81303	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTGATGCCTGGCCGGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.141626686	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192099	175192119	174327371	174327391	81304	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GTCCATCCTCCTTCCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116812544	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192104	175192124	174327376	174327396	81305	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GGAAGGAGGATGGACGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.498063053	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192104	175192124	174327376	174327396	81306	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCGGCGTCCATCCTCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.370739931	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192116	175192136	174327388	174327408	81307	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACGCCGCTGGCATGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.271985862	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192123	175192143	174327395	174327415	81308	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GCTTACCAGGGCACATGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409382735	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192123	175192143	174327395	174327415	81309	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTTACCAGGGCACATGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409382735	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192136	175192156	174327408	174327428	81310	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACAAACAGACACACTTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264207548	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192136	175192156	174327408	174327428	81311	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAAACAGACACACTTACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264207548	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192137	175192157	174327409	174327429	81312	hg19	N/A	enh91318	N/A	N/A	enhancer	enh				GACAAACAGACACACTTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214783177	SP9	chr2	174334953	174338500	7542				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192137	175192157	174327409	174327429	81313	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAAACAGACACACTTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214783177	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192157	175192177	174327429	174327449	81314	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATCAGTGTACATTCTGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092546613	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192164	175192184	174327436	174327456	81315	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTACATTCTGCATGTGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.44832855	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192165	175192185	174327437	174327457	81316	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACATTCTGCATGTGGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07435775	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192170	175192190	174327442	174327462	81317	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTGCATGTGGCAGCAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327065203	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192171	175192191	174327443	174327463	81318	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGCATGTGGCAGCAGGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252552689	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192172	175192192	174327444	174327464	81319	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCATGTGGCAGCAGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.626609123	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192198	175192218	174327470	174327490	81320	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGCACGTGTCTAAAGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.522710734	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192226	175192246	174327498	174327518	81321	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATATACATAGGGGTAGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.668185766	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192230	175192250	174327502	174327522	81322	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGTATATACATAGGGGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.65978634	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192236	175192256	174327508	174327528	81323	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACTGAAGGGTATATACATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.7239137	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192237	175192257	174327509	174327529	81324	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACTGAAGGGTATATACATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167945151	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192238	175192258	174327510	174327530	81325	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGACTGAAGGGTATATACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.76458253	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192250	175192270	174327522	174327542	81326	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTTCTTGGAACATTGACTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.144488311	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192251	175192271	174327523	174327543	81327	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTTCTTGGAACATTGACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.925682022	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192251	175192271	174327523	174327543	81328	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCAGTCAATGTTCCAAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.037920522	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192252	175192272	174327524	174327544	81329	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGTCAATGTTCCAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.551270322	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192257	175192277	174327529	174327549	81330	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAATGTTCCAAGAAGCGGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.75317141	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192258	175192278	174327530	174327550	81331	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATGTTCCAAGAAGCGGGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.268442068	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192261	175192281	174327533	174327553	81332	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTTCCAAGAAGCGGGTCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.619254083	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192266	175192286	174327538	174327558	81333	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTCCGCCCTGACCCGCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.465471678	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192276	175192296	174327548	174327568	81334	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGGGCGGAGGGTATCCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.261354436	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192283	175192303	174327555	174327575	81335	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGGTATCCATCTGGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.550559563	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192287	175192307	174327559	174327579	81336	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTATCCATCTGGACTCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245917533	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192288	175192308	174327560	174327580	81337	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTATCCATCTGGACTCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177688086	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192293	175192313	174327565	174327585	81338	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATCTGGACTCTGGAAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200503667	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192294	175192314	174327566	174327586	81339	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCTGGACTCTGGAAGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.439442516	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192294	175192314	174327566	174327586	81340	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACGCCCTTCCAGAGTCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.093480984	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192305	175192325	174327577	174327597	81341	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGGGCGTGGGTTTGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24610034	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192309	175192329	174327581	174327601	81342	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCGTGGGTTTGACATCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.115067353	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192318	175192338	174327590	174327610	81343	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTTGACATCGGTAGGTGTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.003210914	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192341	175192361	174327613	174327633	81344	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAAGTCCAGCCTGTCAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.93548897	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192342	175192362	174327614	174327634	81345	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGTCCAGCCTGTCAGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221218229	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192349	175192369	174327621	174327641	81346	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGAGCCCAACTCTGACAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.951010733	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192353	175192373	174327625	174327645	81347	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTGTAGAGCCCAACTCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.134001164	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192353	175192373	174327625	174327645	81348	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCAGAGTTGGGCTCTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.643054517	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192369	175192389	174327641	174327661	81349	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAGTGGCCGAAATCAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.618826945	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192373	175192393	174327645	174327665	81350	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGGCCGAAATCAAGAAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.423266723	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192382	175192402	174327654	174327674	81351	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCAAGAAAGGATGGACGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.353498359	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192388	175192408	174327660	174327680	81352	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGGATGGACGTGTCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275149495	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192389	175192409	174327661	174327681	81353	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGATGGACGTGTCGGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.124996268	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192393	175192413	174327665	174327685	81354	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGGACGTGTCGGCCCAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.375319737	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192404	175192424	174327676	174327696	81355	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCCAGGGCTGGCCTGTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.317042187	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192408	175192428	174327680	174327700	81356	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCCGGAAACAGGCCAGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.440114883	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192409	175192429	174327681	174327701	81357	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATCCGGAAACAGGCCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13115237	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192415	175192435	174327687	174327707	81358	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCTGTTTCCGGATATGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.584182954	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192416	175192436	174327688	174327708	81359	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCTGTTTCCGGATATGTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09575093	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192417	175192437	174327689	174327709	81360	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTGTTTCCGGATATGTCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093610354	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192418	175192438	174327690	174327710	81361	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGTTTCCGGATATGTCACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.083571061	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192419	175192439	174327691	174327711	81362	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCCGTGACATATCCGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.497552447	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192426	175192446	174327698	174327718	81363	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGCACCCCCGTGACATATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.441327165	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192435	175192455	174327707	174327727	81364	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGGGGGTGCCTCGTTCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.022538121	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192436	175192456	174327708	174327728	81365	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGGGTGCCTCGTTCCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101226508	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192437	175192457	174327709	174327729	81366	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGGTGCCTCGTTCCTCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073477574	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192446	175192466	174327718	174327738	81367	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAAACTCCCCTCGAGGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141803122	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192453	175192473	174327725	174327745	81368	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACATCCTAAAACTCCCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322113681	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192484	175192504	174327756	174327776	81369	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCACCCTCTCACTGAACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.886551714	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192485	175192505	174327757	174327777	81370	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCACCCTCTCACTGAACTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.50270131	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192490	175192510	174327762	174327782	81371	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCCTACAGTTCAGTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043683929	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192491	175192511	174327763	174327783	81372	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCCTACAGTTCAGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108548713	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192498	175192518	174327770	174327790	81373	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACTGTAGGGTTCTGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.076503708	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192505	175192525	174327777	174327797	81374	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGTTCTGAGAAGAGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.775741378	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192509	175192529	174327781	174327801	81375	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCTGAGAAGAGGTTCTAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.300710795	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192514	175192534	174327786	174327806	81376	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGAGGTTCTAGGAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.054424598	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192523	175192543	174327795	174327815	81377	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTAGGAAGGAGAGGGCTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.868361939	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192543	175192563	174327815	174327835	81378	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGAACTAAGAAAAGAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.859067489	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192557	175192577	174327829	174327849	81379	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCCAGGAGAGTGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.47230668	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192558	175192578	174327830	174327850	81380	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCCAGGAGAGTGGAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23243973	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192564	175192584	174327836	174327856	81381	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTACCCCATGTTCCACTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225533128	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192586	175192606	174327858	174327878	81382	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAAAGACAGATGAGCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295168204	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192587	175192607	174327859	174327879	81383	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAAGACAGATGAGCACAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.680211266	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192615	175192635	174327887	174327907	81384	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGTGAAACCGTGATCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.473687518	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192619	175192639	174327891	174327911	81385	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAACCGTGATCCACCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.309873515	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192620	175192640	174327892	174327912	81386	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAACCGTGATCCACCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.425165462	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192621	175192641	174327893	174327913	81387	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCGTGATCCACCTGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239798818	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192626	175192646	174327898	174327918	81388	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACCCCTTCCAGGTGGATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.670190202	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192633	175192653	174327905	174327925	81389	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGTTTGGAACCCCTTCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.113387495	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192634	175192654	174327906	174327926	81390	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTGGAAGGGGTTCCAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.391884265	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192636	175192656	174327908	174327928	81391	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGGGTTTGGAACCCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.337917119	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192649	175192669	174327921	174327941	81392	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGCGATGTTAGTCCAGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.579051629	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192652	175192672	174327924	174327944	81393	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCTGGACTAACATCGCATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.059163319	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192654	175192674	174327926	174327946	81394	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGTATGCGATGTTAGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286566462	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192655	175192675	174327927	174327947	81395	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCAGTATGCGATGTTAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197402906	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192715	175192735	174327987	174328007	81396	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAATGGGGCTCAGACAGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.011517555	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192716	175192736	174327988	174328008	81397	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTAATGGGGCTCAGACAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.058137113	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192722	175192742	174327994	174328014	81398	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCTGAGCCCCATTATCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.31250294	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192726	175192746	174327998	174328018	81399	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGCCCCATTATCAACCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.015397893	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192731	175192751	174328003	174328023	81400	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGCCTTCCAGGTTGATAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.026142451	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192732	175192752	174328004	174328024	81401	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGCCTTCCAGGTTGATAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.545843142	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192733	175192753	174328005	174328025	81402	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAGCCTTCCAGGTTGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.330797058	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192743	175192763	174328015	174328035	81403	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTGTGGAATGAGAAGCCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01163232	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192790	175192810	174328062	174328082	81404	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGACACTCAAGAACAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.547885154	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192811	175192831	174328083	174328103	81405	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCGGGAAAGGGCTTCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.165059045	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192820	175192840	174328092	174328112	81406	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCTTTCCCGCCAAACCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.12020986	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192822	175192842	174328094	174328114	81407	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTTCGTGGTTTGGCGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.36016552	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192823	175192843	174328095	174328115	81408	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCTTCGTGGTTTGGCGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286931729	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192824	175192844	174328096	174328116	81409	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCCCGCCAAACCACGAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.093731269	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192825	175192845	174328097	174328117	81410	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCCGCCAAACCACGAAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.064881246	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192828	175192848	174328100	174328120	81411	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCCGGCCTTCGTGGTTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.263784608	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192829	175192849	174328101	174328121	81412	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCCCGGCCTTCGTGGTTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05516829	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192846	175192866	174328118	174328138	81413	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCAGGCGCTGTTTATTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134436251	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192847	175192867	174328119	174328139	81414	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAATAAACAGCGCCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.325000733	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192853	175192873	174328125	174328145	81415	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAACAGCGCCTGCCCAGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.182791662	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192854	175192874	174328126	174328146	81416	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAGCGCCTGCCCAGGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.469630963	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192863	175192883	174328135	174328155	81417	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGCGCGCCCAGAGCCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.401657425	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192867	175192887	174328139	174328159	81418	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCTCGCGCGCCCAGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02945248	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192868	175192888	174328140	174328160	81419	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCTCTGGGCGCGCGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.068332158	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192868	175192888	174328140	174328160	81420	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGCTCGCGCGCCCAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.119448872	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192879	175192899	174328151	174328171	81421	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGCGAGCCCAGGAGAGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.561943613	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192880	175192900	174328152	174328172	81422	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGAGCCCAGGAGAGGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.444719601	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192883	175192903	174328155	174328175	81423	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGCCCAGGAGAGGACTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.563211317	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192884	175192904	174328156	174328176	81424	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCCCAGGAGAGGACTTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.405110566	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192888	175192908	174328160	174328180	81425	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCCCACCCAAGTCCTCTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.394536086	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192889	175192909	174328161	174328181	81426	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTTCCCACCCAAGTCCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.046205238	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192904	175192924	174328176	174328196	81427	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGAAGAGGATCTAGAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.495962892	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192908	175192928	174328180	174328200	81428	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGAGGATCTAGAAGATCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.100898093	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192911	175192931	174328183	174328203	81429	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGATCTAGAAGATCGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.852036003	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192912	175192932	174328184	174328204	81430	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATCTAGAAGATCGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.409192795	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192989	175193009	174328261	174328281	81431	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGAAGAGGAGGGACCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.321814391	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175192998	175193018	174328270	174328290	81432	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGGGACCAGCAAGGCAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085939847	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193004	175193024	174328276	174328296	81433	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGCAAGGCAGAGTTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.38300328	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193005	175193025	174328277	174328297	81434	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGCAAGGCAGAGTTGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.012278223	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193006	175193026	174328278	174328298	81435	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAAGGCAGAGTTGGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202818777	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193006	175193026	174328278	174328298	81436	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGGGTCCAACTCTGCCTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.456443113	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193025	175193045	174328297	174328317	81437	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCGGTTATAACAGAACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.769106332	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193026	175193046	174328298	174328318	81438	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGCGGTTATAACAGAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.094561777	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193036	175193056	174328308	174328328	81439	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GATAACCGCCCTTCCCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104360784	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193037	175193057	174328309	174328329	81440	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTAACCGCCCTTCCCCGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.129975361	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193046	175193066	174328318	174328338	81441	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAAAGACCCTGGGCGGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.18908901	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193047	175193067	174328319	174328339	81442	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGAAAGACCCTGGGCGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.039898491	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193051	175193071	174328323	174328343	81443	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGATGGAAAGACCCTGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.666776463	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193052	175193072	174328324	174328344	81444	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGATGGAAAGACCCTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.94610834	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193053	175193073	174328325	174328345	81445	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGGGATGGAAAGACCCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.171033801	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193056	175193076	174328328	174328348	81446	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAGGGGATGGAAAGACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.45412808	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193057	175193077	174328329	174328349	81447	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GACAGGGGATGGAAAGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.03166491	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193079	175193099	174328351	174328371	81448	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGCTCTGAAATGGGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.074440656	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193079	175193099	174328351	174328371	81449	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCAGCTCTGAAATGGGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.074440656	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193080	175193100	174328352	174328372	81450	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTCCCCCATTTCAGAGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.05357376	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193080	175193100	174328352	174328372	81451	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCTCCCCCATTTCAGAGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.05357376	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193080	175193100	174328352	174328372	81452	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCAGCTCTGAAATGGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.292974678	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193080	175193100	174328352	174328372	81453	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTCAGCTCTGAAATGGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.292974678	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193081	175193101	174328353	174328373	81454	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTTCAGCTCTGAAATGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.226521376	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193081	175193101	174328353	174328373	81455	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTTCAGCTCTGAAATGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.226521376	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193082	175193102	174328354	174328374	81456	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCTTCAGCTCTGAAATGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.447941176	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193082	175193102	174328354	174328374	81457	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCTTCAGCTCTGAAATGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.447941176	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193085	175193105	174328357	174328377	81458	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GGCCTTCAGCTCTGAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022241378	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193085	175193105	174328357	174328377	81459	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GGCCTTCAGCTCTGAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022241378	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193086	175193106	174328358	174328378	81460	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCGGCCTTCAGCTCTGAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.243631894	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193086	175193106	174328358	174328378	81461	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCGGCCTTCAGCTCTGAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.243631894	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193087	175193107	174328359	174328379	81462	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCGGCCTTCAGCTCTGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.151036749	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193087	175193107	174328359	174328379	81463	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTCGGCCTTCAGCTCTGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.151036749	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193088	175193108	174328360	174328380	81464	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCGGCCTTCAGCTCTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186196175	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193088	175193108	174328360	174328380	81465	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTCGGCCTTCAGCTCTGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.186196175	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193090	175193110	174328362	174328382	81466	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GTCAGAGCTGAAGGCCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029703922	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193090	175193110	174328362	174328382	81467	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTCAGAGCTGAAGGCCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.029703922	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193091	175193111	174328363	174328383	81468	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GCAGAGCTGAAGGCCGACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.497618051	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193091	175193111	174328363	174328383	81469	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCAGAGCTGAAGGCCGACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.497618051	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193094	175193114	174328366	174328386	81470	hg19	N/A	enh91318	N/A	Enhatls103966	enhancer	enh				GAGCTGAAGGCCGACTGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.320257803	SP9	chr2	174334953	174338500	6587				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193094	175193114	174328366	174328386	81471	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GAGCTGAAGGCCGACTGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.320257803	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193106	175193126	174328378	174328398	81472	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTAACCTCCTCCTCCCACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.105858063	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193111	175193131	174328383	174328403	81473	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GGGAGGAGGAGGTTAAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.081044793	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193112	175193132	174328384	174328404	81474	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GGAGGAGGAGGTTAAACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.393714129	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193128	175193148	174328400	174328420	81475	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCAAAGGGAATCCTCCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.430688333	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193129	175193149	174328401	174328421	81476	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GAAAGGGAATCCTCCTCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021519587	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193133	175193153	174328405	174328425	81477	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GGAATCCTCCTCCTCTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161312978	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193134	175193154	174328406	174328426	81478	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GAATCCTCCTCCTCTGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.65826468	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193141	175193161	174328413	174328433	81479	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GTTCACCCGTCCCAGAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167028502	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193144	175193164	174328416	174328436	81480	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCACTTCACCCGTCCCAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.451557759	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193147	175193167	174328419	174328439	81481	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GACGCACTTCACCCGTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156104087	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-97132	chr2	175193177	175193197	174328449	174328469	81482	hg19	N/A	N/A	N/A	Enhatls103966	enhancer	enh				GCTTGCAGGCTCTGGAAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.074806468	SP9	chr2	174334953	174338500	6502				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9058
enhrx-lit6204	chr2	175193181	175193201	174328453	174328473	81483	hg19					enhancer	enh				GCAGGCTCTGGAAAAACTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.169821139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6205	chr2	175193205	175193225	174328477	174328497	81484	hg19					enhancer	enh				GATTTCCTTGTCGTGAGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.05083761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6206	chr2	175193212	175193232	174328484	174328504	81485	hg19					enhancer	enh				GTCGTCCATCTTCTCACGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.76960331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6207	chr2	175193227	175193247	174328499	174328519	81486	hg19					enhancer	enh				GACGAGTGTGTCTGCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.360556645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6208	chr2	175193250	175193270	174328522	174328542	81487	hg19					enhancer	enh				GAGACAACTACAAACAGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.02779139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6209	chr2	175193251	175193271	174328523	174328543	81488	hg19					enhancer	enh				GACAACTACAAACAGACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.325880769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6210	chr2	175193255	175193275	174328527	174328547	81489	hg19					enhancer	enh				GACTACAAACAGACTTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014807761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6211	chr2	175193256	175193276	174328528	174328548	81490	hg19					enhancer	enh				GCTACAAACAGACTTTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.305140245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6212	chr2	175193260	175193280	174328532	174328552	81491	hg19					enhancer	enh				GAAACAGACTTTGGGCAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.943659865									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6213	chr2	175193318	175193338	174328590	174328610	81492	hg19					enhancer	enh				GAGAGCTGGAGCGATCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.788244186									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6214	chr2	175193333	175193353	174328605	174328625	81493	hg19					enhancer	enh				GAGACAAAATTACAACAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.352078064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6215	chr2	175193350	175193370	174328622	174328642	81494	hg19					enhancer	enh				GTCTTCGCCAGATAGATTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.112116811									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6216	chr2	175193359	175193379	174328631	174328651	81495	hg19					enhancer	enh				GCGGTTCCAGCTAATCTATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.430117678									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6217	chr2	175193370	175193390	174328642	174328662	81496	hg19					enhancer	enh				GTGGAACCGCCAGCCCTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.106856149									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6218	chr2	175193378	175193398	174328650	174328670	81497	hg19					enhancer	enh				GAACTCCAAGCTAGGGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.48484706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6219	chr2	175193381	175193401	174328653	174328673	81498	hg19					enhancer	enh				GACGGAACTCCAAGCTAGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101291654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6220	chr2	175193385	175193405	174328657	174328677	81499	hg19					enhancer	enh				GTAGCTTGGAGTTCCGTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.605508269									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6221	chr2	175193385	175193405	174328657	174328677	81500	hg19					enhancer	enh				GTGGAACGGAACTCCAAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.481280407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6222	chr2	175193386	175193406	174328658	174328678	81501	hg19					enhancer	enh				GTGGAACGGAACTCCAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.19697349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6223	chr2	175193400	175193420	174328672	174328692	81502	hg19					enhancer	enh				GAGGGAGGGTACTCCGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.199825631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6224	chr2	175193426	175193446	174328698	174328718	81503	hg19					enhancer	enh				GCCCCAGCGTCATCTCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.196318489									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6225	chr2	175193428	175193448	174328700	174328720	81504	hg19					enhancer	enh				GCAGGCGCGAGATGACGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.39163381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6226	chr2	175193429	175193449	174328701	174328721	81505	hg19					enhancer	enh				GCCAGGCGCGAGATGACGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.481889943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6227	chr2	175193430	175193450	174328702	174328722	81506	hg19					enhancer	enh				GTCCAGGCGCGAGATGACGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006959623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6228	chr2	175193431	175193451	174328703	174328723	81507	hg19					enhancer	enh				GCTCCAGGCGCGAGATGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.88941366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6229	chr2	175193432	175193452	174328704	174328724	81508	hg19					enhancer	enh				GCGTCATCTCGCGCCTGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.495222836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6230	chr2	175193433	175193453	174328705	174328725	81509	hg19					enhancer	enh				GTCATCTCGCGCCTGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032214741									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6231	chr2	175193447	175193467	174328719	174328739	81510	hg19					enhancer	enh				GAGGAGCGGCGACCCGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.342963125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6232	chr2	175193454	175193474	174328726	174328746	81511	hg19					enhancer	enh				GCTTCGGAAGGAGCGGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.262522579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6233	chr2	175193460	175193480	174328732	174328752	81512	hg19					enhancer	enh				GCGCTCCTTCCGAAGTCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.36018205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6234	chr2	175193462	175193482	174328734	174328754	81513	hg19					enhancer	enh				GCAGCGAGACTTCGGAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.025574367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6235	chr2	175193467	175193487	174328739	174328759	81514	hg19					enhancer	enh				GTTTCCAGCGAGACTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328119959									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6236	chr2	175193471	175193491	174328743	174328763	81515	hg19					enhancer	enh				GAAGTCTCGCTGGAAACTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.196178647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6237	chr2	175193471	175193491	174328743	174328763	81516	hg19					enhancer	enh				GTGAAGTTTCCAGCGAGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.774753036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6238	chr2	175193472	175193492	174328744	174328764	81517	hg19					enhancer	enh				GAGTCTCGCTGGAAACTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.362898315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6239	chr2	175193479	175193499	174328751	174328771	81518	hg19					enhancer	enh				GCTGGAAACTTCAAGGGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.193302109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97133	chr2	175193565	175193585	174328837	174328857	81519	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTAAGTCGTCCTCCCCCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.273150813	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193566	175193586	174328838	174328858	81520	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAAGTCGTCCTCCCCCTCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061114462	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193567	175193587	174328839	174328859	81521	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGTCGTCCTCCCCCTCTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005396666	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193576	175193596	174328848	174328868	81522	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTCTGTCCCCAGAGAGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.981640002	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193579	175193599	174328851	174328871	81523	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCCTCTCTGGGGACAGACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.237105729	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193580	175193600	174328852	174328872	81524	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTCTCTGGGGACAGACTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.423230676	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193580	175193600	174328852	174328872	81525	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTAGAGTCTGTCCCCAGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.160983333	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193581	175193601	174328853	174328873	81526	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTAGAGTCTGTCCCCAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.504198755	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193582	175193602	174328854	174328874	81527	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCCTAGAGTCTGTCCCCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016606469	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193584	175193604	174328856	174328876	81528	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTGGGGACAGACTCTAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.38425916	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193587	175193607	174328859	174328879	81529	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GGGACAGACTCTAGGGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.032012396	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193594	175193614	174328866	174328886	81530	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GACTCTAGGGAAGGAGGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.038383098	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193595	175193615	174328867	174328887	81531	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTCTAGGGAAGGAGGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.931134111	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193605	175193625	174328877	174328897	81532	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GGAGGCAGCTGGGCCCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.198968436	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193606	175193626	174328878	174328898	81533	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGGCAGCTGGGCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.241110641	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193609	175193629	174328881	174328901	81534	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCAGCTGGGCCCGCTCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.064136201	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193618	175193638	174328890	174328910	81535	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCCCGCTCCGGGTGGTGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.159202514	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193621	175193641	174328893	174328913	81536	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCCAAGGACACCACCCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452640256	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193622	175193642	174328894	174328914	81537	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCCAAGGACACCACCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.174987175	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193625	175193645	174328897	174328917	81538	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCGGGTGGTGTCCTTGGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.132685366	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193627	175193647	174328899	174328919	81539	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCGCTAGCCAAGGACACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05172036	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193630	175193650	174328902	174328922	81540	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GGTGTCCTTGGCTAGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334744328	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193638	175193658	174328910	174328930	81541	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCGACGCCACTCCGCTAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.164349476	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193659	175193679	174328931	174328951	81542	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTGTGACCTTCCGCCGCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.316897159	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193660	175193680	174328932	174328952	81543	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTGACCTTCCGCCGCCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.392915003	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193661	175193681	174328933	174328953	81544	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTGACCTTCCGCCGCCCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238246652	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193667	175193687	174328939	174328959	81545	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTCCGCCGCCCCTCGGGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.267314843	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193671	175193691	174328943	174328963	81546	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GACCAAGGCCCCGAGGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.990780161	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193674	175193694	174328946	174328966	81547	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAAGACCAAGGCCCCGAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.605525616	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193677	175193697	174328949	174328969	81548	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGAAAGACCAAGGCCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.340023515	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193678	175193698	174328950	174328970	81549	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTAGAAAGACCAAGGCCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13511964	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193679	175193699	174328951	174328971	81550	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTAGAAAGACCAAGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.606864652	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193687	175193707	174328959	174328979	81551	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAAAGAGCTTAGAAAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.534960262	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193695	175193715	174328967	174328987	81552	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTAAGCTCTTTCTTAGGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.172987067	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193702	175193722	174328974	174328994	81553	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTTTCTTAGGAAGCGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.523227438	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193703	175193723	174328975	174328995	81554	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTTCTTAGGAAGCGGAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.503227961	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193704	175193724	174328976	174328996	81555	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTCTTAGGAAGCGGAGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.602367663	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193733	175193753	174329005	174329025	81556	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GACGTGCACCTCGCCACCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.094427027	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193746	175193766	174329018	174329038	81557	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCACCCACCGGACAAGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.03741631	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193748	175193768	174329020	174329040	81558	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTCTCGGCTTGTCCGGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.354314197	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193751	175193771	174329023	174329043	81559	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTCCTCTCGGCTTGTCCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049339623	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193752	175193772	174329024	174329044	81560	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GGTCCTCTCGGCTTGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.511317738	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193755	175193775	174329027	174329047	81561	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCAAGGTCCTCTCGGCTTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.1013031	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193764	175193784	174329036	174329056	81562	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAAGCAAAGACAAGGTCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.160630687	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193792	175193812	174329064	174329084	81563	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTCTAGATAAATCGCTCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.030743987	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193816	175193836	174329088	174329108	81564	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTCTAAGCTATGACGAACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176441564	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193820	175193840	174329092	174329112	81565	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGCTATGACGAACTAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.421426468	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193821	175193841	174329093	174329113	81566	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCTATGACGAACTAGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051626409	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193826	175193846	174329098	174329118	81567	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GACGAACTAGAGGCTGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.107931077	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193847	175193867	174329119	174329139	81568	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GCGCTGTTCTGGAGAAGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.48662874	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193848	175193868	174329120	174329140	81569	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GACGCTGTTCTGGAGAAGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.247575974	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193849	175193869	174329121	174329141	81570	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTCTTCTCCAGAACAGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.672492505	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193858	175193878	174329130	174329150	81571	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGAACAGCGTGTGGATGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.40779949	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193859	175193879	174329131	174329151	81572	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTTTACATCCACACGCTGTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.110478114	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175193958	175193978	174329230	174329250	81573	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGGTACATTGATCAATCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.267444555	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175194000	175194020	174329272	174329292	81574	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GTGCCACTTGCAGACTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.585334226	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-97133	chr2	175194005	175194025	174329277	174329297	81575	hg19	N/A	N/A	N/A	Enhatls103967	enhancer	enh				GAGCCTGCAGGAGTCTGCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.075610547	SP9	chr2	174334953	174338500	5672				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9059
enhrx-lit6240	chr2	175194016	175194036	174329288	174329308	81576	hg19					enhancer	enh				GCTGCAGGCTCAGATTTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.361764954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6241	chr2	175194017	175194037	174329289	174329309	81577	hg19					enhancer	enh				GTGCAGGCTCAGATTTGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.354471252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6242	chr2	175194018	175194038	174329290	174329310	81578	hg19					enhancer	enh				GCTCTTCAAATCTGAGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.389008306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6243	chr2	175194021	175194041	174329293	174329313	81579	hg19					enhancer	enh				GGCTCAGATTTGAAGAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225529502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6244	chr2	175194049	175194069	174329321	174329341	81580	hg19					enhancer	enh				GAGGCTTAAGGTGGACTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416328261									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6245	chr2	175194053	175194073	174329325	174329345	81581	hg19					enhancer	enh				GACTCAGGCTTAAGGTGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040065771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6246	chr2	175194054	175194074	174329326	174329346	81582	hg19					enhancer	enh				GTCCACCTTAAGCCTGAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134454838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6247	chr2	175194055	175194075	174329327	174329347	81583	hg19					enhancer	enh				GTCCACCTTAAGCCTGAGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.422971465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6248	chr2	175194059	175194079	174329331	174329351	81584	hg19					enhancer	enh				GCCCAAACTCAGGCTTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.445729272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6249	chr2	175194062	175194082	174329334	174329354	81585	hg19					enhancer	enh				GTCGCCCAAACTCAGGCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104874707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6250	chr2	175194069	175194089	174329341	174329361	81586	hg19					enhancer	enh				GTTCTGTAGTCGCCCAAACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.081557439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6251	chr2	175194072	175194092	174329344	174329364	81587	hg19					enhancer	enh				GTTTGGGCGACTACAGAATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.295400087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6252	chr2	175194093	175194113	174329365	174329385	81588	hg19					enhancer	enh				GGAAGAAAATCTAGATGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.339560616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6253	chr2	175194102	175194122	174329374	174329394	81589	hg19					enhancer	enh				GTCTAGATGGCATGGTCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.729262166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6254	chr2	175194117	175194137	174329389	174329409	81590	hg19					enhancer	enh				GCGCTCCGGTCTCAGTTCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08059301									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6255	chr2	175194118	175194138	174329390	174329410	81591	hg19					enhancer	enh				GCTCCGGTCTCAGTTCTACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.357546575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6256	chr2	175194119	175194139	174329391	174329411	81592	hg19					enhancer	enh				GCTCCGGTCTCAGTTCTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.117374927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6257	chr2	175194122	175194142	174329394	174329414	81593	hg19					enhancer	enh				GCGGTCTCAGTTCTACAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.476060157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6258	chr2	175194123	175194143	174329395	174329415	81594	hg19					enhancer	enh				GGTCTCAGTTCTACAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.332258063									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6259	chr2	175194124	175194144	174329396	174329416	81595	hg19					enhancer	enh				GCTCCCCTGTAGAACTGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167323403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6260	chr2	175194144	175194164	174329416	174329436	81596	hg19					enhancer	enh				GGAAGAAAGGGGGTGTTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.443807947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6261	chr2	175194145	175194165	174329417	174329437	81597	hg19					enhancer	enh				GAAGAAAGGGGGTGTTAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.241499563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6262	chr2	175194190	175194210	174329462	174329482	81598	hg19					enhancer	enh				GTGATTTGGAAGGGAGATTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.296368827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6263	chr2	175194191	175194211	174329463	174329483	81599	hg19					enhancer	enh				GCTGATTTGGAAGGGAGATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.24801781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6264	chr2	175194200	175194220	174329472	174329492	81600	hg19					enhancer	enh				GAATCAGTGACTGATTTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002068546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6265	chr2	175194201	175194221	174329473	174329493	81601	hg19					enhancer	enh				GTAATCAGTGACTGATTTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116024311									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6266	chr2	175194235	175194255	174329507	174329527	81602	hg19					enhancer	enh				GTAATCTATAACTTGTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.594465726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6267	chr2	175194237	175194257	174329509	174329529	81603	hg19					enhancer	enh				GCCACAAGTTATAGATTACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201607683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6268	chr2	175194240	175194260	174329512	174329532	81604	hg19					enhancer	enh				GCCACAGTAATCTATAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197098771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6269	chr2	175194301	175194321	174329573	174329593	81605	hg19					enhancer	enh				GCAGACACAGGGATGCAAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.965121119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6270	chr2	175194313	175194333	174329585	174329605	81606	hg19					enhancer	enh				GTTACTGTAAATACAGACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.435533021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6271	chr2	175194314	175194334	174329586	174329606	81607	hg19					enhancer	enh				GTTACTGTAAATACAGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033285904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6272	chr2	175194342	175194362	174329614	174329634	81608	hg19					enhancer	enh				GAGCATATCAGTTTGTGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.38571863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6273	chr2	175194399	175194419	174329671	174329691	81609	hg19					enhancer	enh				GCATCATCAGGAGTTGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.392609492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6274	chr2	175194410	175194430	174329682	174329702	81610	hg19					enhancer	enh				GAGTTGGGATAGGAAATAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.346895179									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6275	chr2	175194411	175194431	174329683	174329703	81611	hg19					enhancer	enh				GTTGGGATAGGAAATAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.316905701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6276	chr2	175194412	175194432	174329684	174329704	81612	hg19					enhancer	enh				GTTGGGATAGGAAATAACATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.443842838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6277	chr2	175194413	175194433	174329685	174329705	81613	hg19					enhancer	enh				GTGGGATAGGAAATAACATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.176182854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6278	chr2	175194416	175194436	174329688	174329708	81614	hg19					enhancer	enh				GATAGGAAATAACATGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.522946576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6279	chr2	175194417	175194437	174329689	174329709	81615	hg19					enhancer	enh				GATAGGAAATAACATGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.060577274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6280	chr2	175194418	175194438	174329690	174329710	81616	hg19					enhancer	enh				GTAGGAAATAACATGGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.824411012									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6281	chr2	175194469	175194489	174329741	174329761	81617	hg19					enhancer	enh				GGACACTCTGGGATAAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.292458841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6282	chr2	175194469	175194489	174329741	174329761	81618	hg19					enhancer	enh				GTCCTTTATCCCAGAGTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.388384015									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6283	chr2	175194472	175194492	174329744	174329764	81619	hg19					enhancer	enh				GTTTATCCCAGAGTGTCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.173195911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6284	chr2	175194473	175194493	174329745	174329765	81620	hg19					enhancer	enh				GTCCAGGACACTCTGGGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.561453009									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6285	chr2	175194480	175194500	174329752	174329772	81621	hg19					enhancer	enh				GCATACCTCCAGGACACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.018467696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6286	chr2	175194481	175194501	174329753	174329773	81622	hg19					enhancer	enh				GGCATACCTCCAGGACACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.277540728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6287	chr2	175194490	175194510	174329762	174329782	81623	hg19					enhancer	enh				GAGGAGTGTAGGCATACCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.323713213									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6288	chr2	175194502	175194522	174329774	174329794	81624	hg19					enhancer	enh				GAAGATGTTAAACAGGAGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.809745307									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6289	chr2	175194510	175194530	174329782	174329802	81625	hg19					enhancer	enh				GACAACCACAAGATGTTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.75311778									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6290	chr2	175194528	175194548	174329800	174329820	81626	hg19					enhancer	enh				GTAGTGCCTTCTCCAAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.069243163									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6291	chr2	175194532	175194552	174329804	174329824	81627	hg19					enhancer	enh				GTGCCTTCTCCAAGCCCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.272570096									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6292	chr2	175194535	175194555	174329807	174329827	81628	hg19					enhancer	enh				GCTTCTCCAAGCCCTGGATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.267953033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6293	chr2	175194537	175194557	174329809	174329829	81629	hg19					enhancer	enh				GCTCCATCCAGGGCTTGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.76325661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6294	chr2	175194538	175194558	174329810	174329830	81630	hg19					enhancer	enh				GCTCCAAGCCCTGGATGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.560391869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6295	chr2	175194543	175194563	174329815	174329835	81631	hg19					enhancer	enh				GTTCCTCCTCCATCCAGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.624974761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6296	chr2	175194548	175194568	174329820	174329840	81632	hg19					enhancer	enh				GACTCTTTCCTCCTCCATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.139353875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6297	chr2	175194549	175194569	174329821	174329841	81633	hg19					enhancer	enh				GAACTCTTTCCTCCTCCATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26353438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6298	chr2	175194576	175194596	174329848	174329868	81634	hg19					enhancer	enh				GTCCTCAAATCTGCCTATGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.347155617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6299	chr2	175194577	175194597	174329849	174329869	81635	hg19					enhancer	enh				GTTTCATAGGCAGATTTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.442521864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6300	chr2	175194577	175194597	174329849	174329869	81636	hg19					enhancer	enh				GCCTCAAATCTGCCTATGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.335325082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6301	chr2	175194580	175194600	174329852	174329872	81637	hg19					enhancer	enh				GCCCTTTCATAGGCAGATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.212618553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6302	chr2	175194588	175194608	174329860	174329880	81638	hg19					enhancer	enh				GCCTATGAAAGGGTAAAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.046287344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6303	chr2	175194595	175194615	174329867	174329887	81639	hg19					enhancer	enh				GAAGGGTAAAACTGAGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.507128539									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6304	chr2	175194623	175194643	174329895	174329915	81640	hg19					enhancer	enh				GTACTCAGCTTCTCATAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.273650432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6305	chr2	175194638	175194658	174329910	174329930	81641	hg19					enhancer	enh				GAGTAATGATCAGAATCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.191633324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6306	chr2	175194645	175194665	174329917	174329937	81642	hg19					enhancer	enh				GATCAGAATCCTCTGGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06896953									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6307	chr2	175194664	175194684	174329936	174329956	81643	hg19					enhancer	enh				GCTAATATCAAGAAAAGCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099355036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6308	chr2	175194705	175194725	174329977	174329997	81644	hg19					enhancer	enh				GTGCTTTAGTGTCTCCAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167057551									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6309	chr2	175194720	175194740	174329992	174330012	81645	hg19					enhancer	enh				GAAAGGTGGTTCCATTAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108986708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6310	chr2	175194721	175194741	174329993	174330013	81646	hg19					enhancer	enh				GAACTCTAATGGAACCACCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.25854864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6311	chr2	175194733	175194753	174330005	174330025	81647	hg19					enhancer	enh				GATTGTCTCAGCCAACTCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157971616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6312	chr2	175194748	175194768	174330020	174330040	81648	hg19					enhancer	enh				GACAATACATGTGCATCATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.039546395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6313	chr2	175194800	175194820	174330072	174330092	81649	hg19					enhancer	enh				GCAAATGTGGCATTCTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.567241694									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6314	chr2	175194802	175194822	174330074	174330094	81650	hg19					enhancer	enh				GACAGAATGCCACATTTGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.20062091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6315	chr2	175194813	175194833	174330085	174330105	81651	hg19					enhancer	enh				GTCTTAGACCTAAGCAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.415176306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6316	chr2	175194820	175194840	174330092	174330112	81652	hg19					enhancer	enh				GTTAGGTCTAAGACCCTTCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136761087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6317	chr2	175194827	175194847	174330099	174330119	81653	hg19					enhancer	enh				GTAAGACCCTTCTGTGGTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.444150709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6318	chr2	175194832	175194852	174330104	174330124	81654	hg19					enhancer	enh				GCCCTTCTGTGGTAGTCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.604350466									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6319	chr2	175194833	175194853	174330105	174330125	81655	hg19					enhancer	enh				GCCTTCTGTGGTAGTCGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.089735108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6320	chr2	175194835	175194855	174330107	174330127	81656	hg19					enhancer	enh				GCCTCACCGACTACCACAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.239879938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6321	chr2	175194836	175194856	174330108	174330128	81657	hg19					enhancer	enh				GCCCTCACCGACTACCACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.335009086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6322	chr2	175194865	175194885	174330137	174330157	81658	hg19					enhancer	enh				GAGTAAAACCCCAAGCTGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.180419065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6323	chr2	175194875	175194895	174330147	174330167	81659	hg19					enhancer	enh				GTGGGGGGCCTATTCAGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.141539054									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6324	chr2	175194876	175194896	174330148	174330168	81660	hg19					enhancer	enh				GATGGGGGGCCTATTCAGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.234557675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6325	chr2	175194877	175194897	174330149	174330169	81661	hg19					enhancer	enh				GTATGGGGGGCCTATTCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.167383309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6326	chr2	175194891	175194911	174330163	174330183	81662	hg19					enhancer	enh				GCATCACTCGGAAACTATGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.461244195									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6327	chr2	175194892	175194912	174330164	174330184	81663	hg19					enhancer	enh				GCATCACTCGGAAACTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.351688949									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6328	chr2	175194893	175194913	174330165	174330185	81664	hg19					enhancer	enh				GTGCATCACTCGGAAACTATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.086044256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6329	chr2	175194894	175194914	174330166	174330186	81665	hg19					enhancer	enh				GCTGCATCACTCGGAAACTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.240804928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6330	chr2	175194895	175194915	174330167	174330187	81666	hg19					enhancer	enh				GACTGCATCACTCGGAAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.214716596									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6331	chr2	175194993	175195013	174330265	174330285	81667	hg19					enhancer	enh				GCTGGTGTGTCAAAGGAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.451466235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6332	chr2	175194997	175195017	174330269	174330289	81668	hg19					enhancer	enh				GAAGACTGGTGTGTCAAAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.200887635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6333	chr2	175195001	175195021	174330273	174330293	81669	hg19					enhancer	enh				GGGAAAGACTGGTGTGTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.579272889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6334	chr2	175195012	175195032	174330284	174330304	81670	hg19					enhancer	enh				GTTAACAATTAAGGGAAAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.250605018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6335	chr2	175195021	175195041	174330293	174330313	81671	hg19					enhancer	enh				GAAAAATGCATTAACAATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.181878731									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6336	chr2	175195022	175195042	174330294	174330314	81672	hg19					enhancer	enh				GCAAAAATGCATTAACAATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149956849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6337	chr2	175195040	175195060	174330312	174330332	81673	hg19					enhancer	enh				GTGGCTCAGATAAACACATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.91717431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6338	chr2	175195058	175195078	174330330	174330350	81674	hg19					enhancer	enh				GAGAGGCCAGCTTAAAATATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.540825732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6339	chr2	175195126	175195146	174330398	174330418	81675	hg19					enhancer	enh				GTGGACTGTGCTTAATAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.316334909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6340	chr2	175195127	175195147	174330399	174330419	81676	hg19					enhancer	enh				GGACTGTGCTTAATAGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263765343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6341	chr2	175195128	175195148	174330400	174330420	81677	hg19					enhancer	enh				GACTGTGCTTAATAGACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.540329382									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6342	chr2	175195159	175195179	174330431	174330451	81678	hg19					enhancer	enh				GTTCTTCAGCAGACCCTACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.315127784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6343	chr2	175195207	175195227	174330479	174330499	81679	hg19					enhancer	enh				GCGTCACTGCTATTTAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.115085437									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6344	chr2	175195257	175195277	174330529	174330549	81680	hg19					enhancer	enh				GAAAAAAGATGAAAGTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.381823767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6345	chr2	175195275	175195295	174330547	174330567	81681	hg19					enhancer	enh				GGAAGATTCAATAGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041625056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6346	chr2	175195276	175195296	174330548	174330568	81682	hg19					enhancer	enh				GAGGAAGATTCAATAGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.99739139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6347	chr2	175195283	175195303	174330555	174330575	81683	hg19					enhancer	enh				GAAGAGCAAGGAAGATTCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014935439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6348	chr2	175195296	175195316	174330568	174330588	81684	hg19					enhancer	enh				GCCCTTGCAAATGAAAGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.760208095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6349	chr2	175195302	175195322	174330574	174330594	81685	hg19					enhancer	enh				GTTCATTTGCAAGGGTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.449630474									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6350	chr2	175195309	175195329	174330581	174330601	81686	hg19					enhancer	enh				GCAAGGGTTGGGCTGGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.049218361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6351	chr2	175195354	175195374	174330626	174330646	81687	hg19					enhancer	enh				GGAAAGCTTAACAGAAACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.65562867									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6352	chr2	175195355	175195375	174330627	174330647	81688	hg19					enhancer	enh				GAAAGCTTAACAGAAACTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102899379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6353	chr2	175195409	175195429	174330681	174330701	81689	hg19					enhancer	enh				GATCCATTTGATCTCAACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.705352488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6354	chr2	175195410	175195430	174330682	174330702	81690	hg19					enhancer	enh				GAGTTGTTGAGATCAAATGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.595078407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6355	chr2	175195414	175195434	174330686	174330706	81691	hg19					enhancer	enh				GCACCAGTTGTTGAGATCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.356785863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6356	chr2	175195465	175195485	174330737	174330757	81692	hg19					enhancer	enh				GAAAGATTCCCTGCTAATCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334870033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6357	chr2	175195475	175195495	174330747	174330767	81693	hg19					enhancer	enh				GAATACAGCCTTTGATTAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.369453352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6358	chr2	175195476	175195496	174330748	174330768	81694	hg19					enhancer	enh				GAAATACAGCCTTTGATTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.232783584									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6359	chr2	175195509	175195529	174330781	174330801	81695	hg19					enhancer	enh				GCACTGACAAGACACCAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.080993335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6360	chr2	175195511	175195531	174330783	174330803	81696	hg19					enhancer	enh				GCACGGTTGGTGTCTTGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371856526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6361	chr2	175195514	175195534	174330786	174330806	81697	hg19					enhancer	enh				GACAAGACACCAACCGTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.183234447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6362	chr2	175195525	175195545	174330797	174330817	81698	hg19					enhancer	enh				GGGTGAATCCTTTCCACGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.764715665									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6363	chr2	175195529	175195549	174330801	174330821	81699	hg19					enhancer	enh				GAGTCGGGTGAATCCTTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.182156625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6364	chr2	175195533	175195553	174330805	174330825	81700	hg19					enhancer	enh				GAAGGATTCACCCGACTCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342872869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6365	chr2	175195541	175195561	174330813	174330833	81701	hg19					enhancer	enh				GACCCGACTCAACAGGCACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.042629908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6366	chr2	175195545	175195565	174330817	174330837	81702	hg19					enhancer	enh				GTCCATAGTGCCTGTTGAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057359668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6367	chr2	175195546	175195566	174330818	174330838	81703	hg19					enhancer	enh				GTCCATAGTGCCTGTTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137046442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6368	chr2	175195551	175195571	174330823	174330843	81704	hg19					enhancer	enh				GACAGGCACTATGGACCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.823989638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6369	chr2	175195552	175195572	174330824	174330844	81705	hg19					enhancer	enh				GCAGGCACTATGGACCTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250476066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6370	chr2	175195581	175195601	174330853	174330873	81706	hg19					enhancer	enh				GCCTGCCATGAACAAGGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.017402238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6371	chr2	175195587	175195607	174330859	174330879	81707	hg19					enhancer	enh				GTTGTTCATGGCAGGCAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.112385858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6372	chr2	175195587	175195607	174330859	174330879	81708	hg19					enhancer	enh				GATGTTGCCTGCCATGAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.252806323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6373	chr2	175195588	175195608	174330860	174330880	81709	hg19					enhancer	enh				GAATGTTGCCTGCCATGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.071594502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6374	chr2	175195596	175195616	174330868	174330888	81710	hg19					enhancer	enh				GCAGGCAACATTGGTACACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.499988895									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6375	chr2	175195597	175195617	174330869	174330889	81711	hg19					enhancer	enh				GCAGGCAACATTGGTACACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.074408674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6376	chr2	175195662	175195682	174330934	174330954	81712	hg19					enhancer	enh				GTCAGCACGGTGTGGGAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.825516697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6377	chr2	175195670	175195690	174330942	174330962	81713	hg19					enhancer	enh				GTTATCAGGTCAGCACGGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.142166761									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6378	chr2	175195671	175195691	174330943	174330963	81714	hg19					enhancer	enh				GATTATCAGGTCAGCACGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.097073266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6379	chr2	175195676	175195696	174330948	174330968	81715	hg19					enhancer	enh				GCAGTGATTATCAGGTCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08738753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6380	chr2	175195685	175195705	174330957	174330977	81716	hg19					enhancer	enh				GTCACTAGAGCAGTGATTATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.691230709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6381	chr2	175195742	175195762	174331014	174331034	81717	hg19					enhancer	enh				GTGATTTAAAAAGGAGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.533058697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6382	chr2	175195761	175195781	174331033	174331053	81718	hg19					enhancer	enh				GTGGCTTTGCAAATAAATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.305729689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6383	chr2	175195768	175195788	174331040	174331060	81719	hg19					enhancer	enh				GTGCAAATAAATAAAGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.510975312									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6384	chr2	175195769	175195789	174331041	174331061	81720	hg19					enhancer	enh				GCAAATAAATAAAGGCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.31937508									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6385	chr2	175195772	175195792	174331044	174331064	81721	hg19					enhancer	enh				GAATAAATAAAGGCAGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.664736077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6386	chr2	175195777	175195797	174331049	174331069	81722	hg19					enhancer	enh				GATAAAGGCAGTTGGGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.357598122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6387	chr2	175195839	175195859	174331111	174331131	81723	hg19					enhancer	enh				GCCACCCCCGCCTCCTGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.066631413									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6388	chr2	175195842	175195862	174331114	174331134	81724	hg19					enhancer	enh				GCCCCCGCCTCCTGGTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1788705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6389	chr2	175195846	175195866	174331118	174331138	81725	hg19					enhancer	enh				GACCACCGGGACCAGGAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.340279558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6390	chr2	175195847	175195867	174331119	174331139	81726	hg19					enhancer	enh				GACCACCGGGACCAGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.683912899									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6391	chr2	175195848	175195868	174331120	174331140	81727	hg19					enhancer	enh				GGACCACCGGGACCAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.485356121									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6392	chr2	175195851	175195871	174331123	174331143	81728	hg19					enhancer	enh				GTCTGGACCACCGGGACCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06906233									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6393	chr2	175195854	175195874	174331126	174331146	81729	hg19					enhancer	enh				GAAGTCTGGACCACCGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175243516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6394	chr2	175195860	175195880	174331132	174331152	81730	hg19					enhancer	enh				GCAGTCAAAGTCTGGACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.077285124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6395	chr2	175195861	175195881	174331133	174331153	81731	hg19					enhancer	enh				GCAGTCAAAGTCTGGACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.012652069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6396	chr2	175195869	175195889	174331141	174331161	81732	hg19					enhancer	enh				GGCTGGCTGCAGTCAAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.718284779									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6397	chr2	175195869	175195889	174331141	174331161	81733	hg19					enhancer	enh				GACTTTGACTGCAGCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.416881703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6398	chr2	175195875	175195895	174331147	174331167	81734	hg19					enhancer	enh				GACTGCAGCCAGCCTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.259869402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6399	chr2	175195886	175195906	174331158	174331178	81735	hg19					enhancer	enh				GGTGCTCGCCTTGGCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072882392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6400	chr2	175195890	175195910	174331162	174331182	81736	hg19					enhancer	enh				GGAAGGTGCTCGCCTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06126098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6401	chr2	175195895	175195915	174331167	174331187	81737	hg19					enhancer	enh				GGAACGGAAGGTGCTCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136076921									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6402	chr2	175195928	175195948	174331200	174331220	81738	hg19					enhancer	enh				GCCTCCCCTTCAACCTTATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.421820434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6403	chr2	175195931	175195951	174331203	174331223	81739	hg19					enhancer	enh				GCCGGAATAAGGTTGAAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.013769536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6404	chr2	175195934	175195954	174331206	174331226	81740	hg19					enhancer	enh				GACTCCGGAATAAGGTTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.125235248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6405	chr2	175195935	175195955	174331207	174331227	81741	hg19					enhancer	enh				GACTCCGGAATAAGGTTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.201791686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6406	chr2	175195936	175195956	174331208	174331228	81742	hg19					enhancer	enh				GGACTCCGGAATAAGGTTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.747265081									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6407	chr2	175195943	175195963	174331215	174331235	81743	hg19					enhancer	enh				GTTAGGGGGACTCCGGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.712341807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6408	chr2	175195991	175196011	174331263	174331283	81744	hg19					enhancer	enh				GGGTATACACCACTGGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.201278709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6409	chr2	175195992	175196012	174331264	174331284	81745	hg19					enhancer	enh				GCGGGTATACACCACTGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.061851326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6410	chr2	175195993	175196013	174331265	174331285	81746	hg19					enhancer	enh				GCGGGTATACACCACTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.184352956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6411	chr2	175195996	175196016	174331268	174331288	81747	hg19					enhancer	enh				GCAGCGGGTATACACCACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.222402735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6412	chr2	175195997	175196017	174331269	174331289	81748	hg19					enhancer	enh				GAGCAGCGGGTATACACCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149851164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6413	chr2	175195998	175196018	174331270	174331290	81749	hg19					enhancer	enh				GTAGCAGCGGGTATACACCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.255882832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6414	chr2	175196009	175196029	174331281	174331301	81750	hg19					enhancer	enh				GCCGCTGCTAGACTCTGTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.595500603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6415	chr2	175196011	175196031	174331283	174331303	81751	hg19					enhancer	enh				GCTAGCACAGAGTCTAGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045536625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6416	chr2	175196012	175196032	174331284	174331304	81752	hg19					enhancer	enh				GCCTAGCACAGAGTCTAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.143028011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6417	chr2	175196021	175196041	174331293	174331313	81753	hg19					enhancer	enh				GTCTGTGCTAGGTCAAAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228238991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6418	chr2	175196022	175196042	174331294	174331314	81754	hg19					enhancer	enh				GCTGTGCTAGGTCAAAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.269314221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6419	chr2	175196023	175196043	174331295	174331315	81755	hg19					enhancer	enh				GTGTGCTAGGTCAAAGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.348147057									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97134	chr2	175196030	175196050	174331302	174331322	81756	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGTCAAAGCTCCGGGGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.147833599	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196031	175196051	174331303	174331323	81757	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCAAAGCTCCGGGGAGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.155955227	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196043	175196063	174331315	174331335	81758	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGGTGGCTGCCCAGTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.241676435	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196060	175196080	174331332	174331352	81759	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTAGCTGGTTAAATATTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087928898	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196075	175196095	174331347	174331367	81760	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATAACTGGATATGTAGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.239898417	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196087	175196107	174331359	174331379	81761	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCAGTTATTCAGAAAATAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.06082266	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196114	175196134	174331386	174331406	81762	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAGCGTAGTGGCGACTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.010432799	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196117	175196137	174331389	174331409	81763	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCAGGAAGCGTAGTGGCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.000704526	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196118	175196138	174331390	174331410	81764	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCAGGAAGCGTAGTGGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.313619881	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196123	175196143	174331395	174331415	81765	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCACTACGCTTCCTGCACATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.473980704	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196125	175196145	174331397	174331417	81766	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTGATGTGCAGGAAGCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.088818644	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196161	175196181	174331433	174331453	81767	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTGTGGCTATTGGACCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021479291	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196164	175196184	174331436	174331456	81768	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGCTATTGGACCTGTGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.251339025	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196177	175196197	174331449	174331469	81769	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAGGATTGGACCTCCTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036038695	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196191	175196211	174331463	174331483	81770	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTAGCGCTAATCGGAAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.34583261	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196196	175196216	174331468	174331488	81771	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGTCATTAGCGCTAATCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286423139	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196200	175196220	174331472	174331492	81772	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATTCGGTCATTAGCGCTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00448383	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196208	175196228	174331480	174331500	81773	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTAATGACCGAATTGTTTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.032094588	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196217	175196237	174331489	174331509	81774	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCAAAGCCAGGGAAACAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.412196022	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196228	175196248	174331500	174331520	81775	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTGTTTAGCAGGCAAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.449730012	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196229	175196249	174331501	174331521	81776	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCTGTTTAGCAGGCAAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.062448927	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196261	175196281	174331533	174331553	81777	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTGCTCAGATCAAAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099087768	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196262	175196282	174331534	174331554	81778	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTGCTCAGATCAAAGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.385121533	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196267	175196287	174331539	174331559	81779	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCAGATCAAAGCTCCCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.496072126	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196275	175196295	174331547	174331567	81780	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGCTCCCGGGAGAGGCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.015635751	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196276	175196296	174331548	174331568	81781	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTCCCGGGAGAGGCAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.138777702	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196282	175196302	174331554	174331574	81782	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCTCCCATCTTGCCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116115696	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196298	175196318	174331570	174331590	81783	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGAAACAATATTTGTTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.244739837	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196336	175196356	174331608	174331628	81784	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGAAGAATAGGGTAATTAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.128989392	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196337	175196357	174331609	174331629	81785	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAGAAGAATAGGGTAATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.256979141	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196347	175196367	174331619	174331639	81786	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATTCCTAATAAAGAAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.409936106	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196348	175196368	174331620	174331640	81787	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATTCCTAATAAAGAAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.246237693	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196409	175196429	174331681	174331701	81788	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTTACATCATAAATACACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.449690157	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196432	175196452	174331704	174331724	81789	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATTCCAAGATGAAAACGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.072470051	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196446	175196466	174331718	174331738	81790	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GACGTCACGGATCAATTGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.180427468	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196452	175196472	174331724	174331744	81791	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCGGATCAATTGTAAAGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.016655428	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196523	175196543	174331795	174331815	81792	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTGACTGAGCAGCGAAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.795036731	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196524	175196544	174331796	174331816	81793	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCTGACTGAGCAGCGAAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.203661796	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196525	175196545	174331797	174331817	81794	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATCTGACTGAGCAGCGAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.665699772	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196589	175196609	174331861	174331881	81795	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTGCAATCAGGGCAATTTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225770059	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196592	175196612	174331864	174331884	81796	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAATTGCCCTGATTGCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.471508432	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196593	175196613	174331865	174331885	81797	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAATTGCCCTGATTGCAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.316242715	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196664	175196684	174331936	174331956	81798	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTCACCTCTTTATAAAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044450447	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196672	175196692	174331944	174331964	81799	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTTATAAAGAAGTGGAGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.52470807	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196678	175196698	174331950	174331970	81800	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAGAAGTGGAGATAAGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.661644833	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196679	175196699	174331951	174331971	81801	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGAAGTGGAGATAAGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.202409562	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196680	175196700	174331952	174331972	81802	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAGTGGAGATAAGGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.87724131	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196700	175196720	174331972	174331992	81803	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTGCAATTTGTGCAAAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.157154114	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196703	175196723	174331975	174331995	81804	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCTTTGCACAAATTGCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.311121126	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196704	175196724	174331976	174331996	81805	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTTTGCACAAATTGCACTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.490506483	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196705	175196725	174331977	174331997	81806	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTTTGCACAAATTGCACTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.429911889	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196706	175196726	174331978	174331998	81807	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCTAAGTGCAATTTGTGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.775392398	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196713	175196733	174331985	174332005	81808	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAATTGCACTTAGGGGCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.715027383	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196724	175196744	174331996	174332016	81809	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGGGCTGACTGGCAGCATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.360684534	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196747	175196767	174332019	174332039	81810	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCGCTATAATAGAGCATTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173729205	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196773	175196793	174332045	174332065	81811	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GACGCTTTACATTATTCAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.093545955	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196838	175196858	174332110	174332130	81812	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTGATGATTCACTCCAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.348594208	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196854	175196874	174332126	174332146	81813	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAATGTAACAAAGGCCTGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.287346119	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196859	175196879	174332131	174332151	81814	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATGACAATGTAACAAAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.476541355	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196864	175196884	174332136	174332156	81815	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAATAATGACAATGTAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.855314242	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196887	175196907	174332159	174332179	81816	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTGACTGTTAAAACATTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.539599739	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196888	175196908	174332160	174332180	81817	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGCTGACTGTTAAAACATTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040877413	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196889	175196909	174332161	174332181	81818	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAGCTGACTGTTAAAACATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.636133319	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196973	175196993	174332245	174332265	81819	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCTGTCAGACGAAAAAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.024546385	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196997	175197017	174332269	174332289	81820	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTTCCTCCGAAAGATTTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183218186	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175196999	175197019	174332271	174332291	81821	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCCTCCGAAAGATTTCCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.191597889	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197003	175197023	174332275	174332295	81822	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCCCAAGGAAATCTTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033108608	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197006	175197026	174332278	174332298	81823	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGGGCCCCAAGGAAATCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00137989	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197017	175197037	174332289	174332309	81824	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAACTCTAAGGTGGGGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.325553473	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197021	175197041	174332293	174332313	81825	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCCCACCTTAGAGTTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.338177598	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197025	175197045	174332297	174332317	81826	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCACTTCAACTCTAAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.07299762	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197026	175197046	174332298	174332318	81827	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGCCACTTCAACTCTAAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.129194091	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197026	175197046	174332298	174332318	81828	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GACCTTAGAGTTGAAGTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.356606952	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197027	175197047	174332299	174332319	81829	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GGGCCACTTCAACTCTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101303827	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197027	175197047	174332299	174332319	81830	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCTTAGAGTTGAAGTGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.03931823	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197030	175197050	174332302	174332322	81831	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCCCGGGCCACTTCAACTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.30668185	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197047	175197067	174332319	174332339	81832	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GACGAACGCAGGCAAACACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.284840977	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197048	175197068	174332320	174332340	81833	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAACGAACGCAGGCAAACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176937661	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197059	175197079	174332331	174332351	81834	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GAAATCTTCCAAACGAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.105949311	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197081	175197101	174332353	174332373	81835	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GCTGCATCACAATAAAAGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114323121	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197082	175197102	174332354	174332374	81836	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GTCTGCATCACAATAAAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148184182	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-97134	chr2	175197095	175197115	174332367	174332387	81837	hg19	hs860	N/A	N/A	N/A	enhancer	enh				GATGCAGACGCGTGTATCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.074910523	SP9	chr2	174334953	174338500	2568				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9060
enhrx-lit6420	chr2	175197132	175197152	174332404	174332424	81838	hg19					enhancer	enh				GCACGTCTAGAGTCTGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.725809661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6421	chr2	175197133	175197153	174332405	174332425	81839	hg19					enhancer	enh				GAGCTGTCAGACTCTAGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.104616649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6422	chr2	175197134	175197154	174332406	174332426	81840	hg19					enhancer	enh				GCAGCTGTCAGACTCTAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.414410844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6423	chr2	175197140	175197160	174332412	174332432	81841	hg19					enhancer	enh				GAGTCTGACAGCTGGAACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.391536498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6424	chr2	175197141	175197161	174332413	174332433	81842	hg19					enhancer	enh				GAGTCTGACAGCTGGAACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.624422706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6425	chr2	175197142	175197162	174332414	174332434	81843	hg19					enhancer	enh				GTCTGACAGCTGGAACTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.087400459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6426	chr2	175197149	175197169	174332421	174332441	81844	hg19					enhancer	enh				GAGCTGGAACTACGGGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.500715044									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6427	chr2	175197152	175197172	174332424	174332444	81845	hg19					enhancer	enh				GTGGAACTACGGGGAAAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.38288259									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6428	chr2	175197153	175197173	174332425	174332445	81846	hg19					enhancer	enh				GGAACTACGGGGAAAACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.493455425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6429	chr2	175197156	175197176	174332428	174332448	81847	hg19					enhancer	enh				GACTACGGGGAAAACGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.456879917									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6430	chr2	175197157	175197177	174332429	174332449	81848	hg19					enhancer	enh				GCTACGGGGAAAACGGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.363716774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6431	chr2	175197206	175197226	174332478	174332498	81849	hg19					enhancer	enh				GGAGAAGAGGAAGGCGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.38862456									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6432	chr2	175197221	175197241	174332493	174332513	81850	hg19					enhancer	enh				GAGCAGGGCGCCGGAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.581472605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6433	chr2	175197234	175197254	174332506	174332526	81851	hg19					enhancer	enh				GCTCGCAGACACCTCGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15433394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6434	chr2	175197240	175197260	174332512	174332532	81852	hg19					enhancer	enh				GACAGTTCTCGCAGACACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200474842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6435	chr2	175197241	175197261	174332513	174332533	81853	hg19					enhancer	enh				GAACAGTTCTCGCAGACACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.324954756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6436	chr2	175197277	175197297	174332549	174332569	81854	hg19					enhancer	enh				GAAAATGTCACTAGTGCTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.137350398									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6437	chr2	175197327	175197347	174332599	174332619	81855	hg19					enhancer	enh				GTGTCAGGTTTCCTTAAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.109158336									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6438	chr2	175197328	175197348	174332600	174332620	81856	hg19					enhancer	enh				GTCAGGTTTCCTTAAGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.172903756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6439	chr2	175197336	175197356	174332608	174332628	81857	hg19					enhancer	enh				GTCCTTAAGGAGAGGGTGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.252480515									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6440	chr2	175197337	175197357	174332609	174332629	81858	hg19					enhancer	enh				GCCTTAAGGAGAGGGTGTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.489651954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6441	chr2	175197338	175197358	174332610	174332630	81859	hg19					enhancer	enh				GCTTAAGGAGAGGGTGTGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.371960211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6442	chr2	175197340	175197360	174332612	174332632	81860	hg19					enhancer	enh				GCCCAACACACCCTCTCCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020989455									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6443	chr2	175197390	175197410	174332662	174332682	81861	hg19					enhancer	enh				GCCGAGGAGGAGAAACGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05411145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6444	chr2	175197395	175197415	174332667	174332687	81862	hg19					enhancer	enh				GTTTCTCCTCCTCGGCTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.257378236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6445	chr2	175197396	175197416	174332668	174332688	81863	hg19					enhancer	enh				GTTCTCCTCCTCGGCTGCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.38183322									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6446	chr2	175197403	175197423	174332675	174332695	81864	hg19					enhancer	enh				GCTCACCCTGTGCAGCCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021685173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6447	chr2	175197404	175197424	174332676	174332696	81865	hg19					enhancer	enh				GCTCGGCTGCACAGGGTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.787055713									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6448	chr2	175197406	175197426	174332678	174332698	81866	hg19					enhancer	enh				GCTACTCACCCTGTGCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.00648552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6449	chr2	175197435	175197455	174332707	174332727	81867	hg19					enhancer	enh				GGGATTGTTAAGTGGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.028706383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6450	chr2	175197443	175197463	174332715	174332735	81868	hg19					enhancer	enh				GCTAATAGAGGGATTGTTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150579988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6451	chr2	175197453	175197473	174332725	174332745	81869	hg19					enhancer	enh				GCCTCTATTAGTAAATCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033014543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6452	chr2	175197455	175197475	174332727	174332747	81870	hg19					enhancer	enh				GCGCGTAGATTTACTAATAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159009924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6453	chr2	175197456	175197476	174332728	174332748	81871	hg19					enhancer	enh				GCCGCGTAGATTTACTAATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.654509426									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6454	chr2	175197464	175197484	174332736	174332756	81872	hg19					enhancer	enh				GAAATCTACGCGGAGACTCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.408871712									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6455	chr2	175197465	175197485	174332737	174332757	81873	hg19					enhancer	enh				GAATCTACGCGGAGACTCTAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.150799777									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6456	chr2	175197494	175197514	174332766	174332786	81874	hg19					enhancer	enh				GTGGAAGAAGACACTGGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.04998735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6457	chr2	175197494	175197514	174332766	174332786	81875	hg19					enhancer	enh				GAGAACCAGTGTCTTCTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.122616851									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6458	chr2	175197501	175197521	174332773	174332793	81876	hg19					enhancer	enh				GTCTGCCCTGGAAGAAGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.131905927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6459	chr2	175197511	175197531	174332783	174332803	81877	hg19					enhancer	enh				GCCAGGGCAGAAGTCACCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.060608069									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6460	chr2	175197512	175197532	174332784	174332804	81878	hg19					enhancer	enh				GCAGGGCAGAAGTCACCTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.16211801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6461	chr2	175197514	175197534	174332786	174332806	81879	hg19					enhancer	enh				GCCAACAGGTGACTTCTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.46371763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6462	chr2	175197517	175197537	174332789	174332809	81880	hg19					enhancer	enh				GCAGAAGTCACCTGTTGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021028234									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6463	chr2	175197524	175197544	174332796	174332816	81881	hg19					enhancer	enh				GCACCTGTTGGGAACGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.357420821									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6464	chr2	175197525	175197545	174332797	174332817	81882	hg19					enhancer	enh				GACCTGTTGGGAACGGCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127921028									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6465	chr2	175197529	175197549	174332801	174332821	81883	hg19					enhancer	enh				GACCCGGGGGCCGTTCCCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.216993969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6466	chr2	175197537	175197557	174332809	174332829	81884	hg19					enhancer	enh				GCGGCCCCCGGGTCCCCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.289806924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6467	chr2	175197538	175197558	174332810	174332830	81885	hg19					enhancer	enh				GGCCCCCGGGTCCCCCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254142123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6468	chr2	175197543	175197563	174332815	174332835	81886	hg19					enhancer	enh				GAGCCCAGCAGGGGGACCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.311633154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6469	chr2	175197544	175197564	174332816	174332836	81887	hg19					enhancer	enh				GAAGCCCAGCAGGGGGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.313367292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6470	chr2	175197545	175197565	174332817	174332837	81888	hg19					enhancer	enh				GAAAGCCCAGCAGGGGGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09335841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6471	chr2	175197546	175197566	174332818	174332838	81889	hg19					enhancer	enh				GGTCCCCCTGCTGGGCTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043689636									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6472	chr2	175197546	175197566	174332818	174332838	81890	hg19					enhancer	enh				GAAAGCCCAGCAGGGGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.018669702									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6473	chr2	175197552	175197572	174332824	174332844	81891	hg19					enhancer	enh				GAGCCGGAAAGCCCAGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.10759472									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6474	chr2	175197553	175197573	174332825	174332845	81892	hg19					enhancer	enh				GAGAGCCGGAAAGCCCAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072336281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6475	chr2	175197554	175197574	174332826	174332846	81893	hg19					enhancer	enh				GAAGAGCCGGAAAGCCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.129244963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6476	chr2	175197555	175197575	174332827	174332847	81894	hg19					enhancer	enh				GAAGAGCCGGAAAGCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.337223285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6477	chr2	175197559	175197579	174332831	174332851	81895	hg19					enhancer	enh				GGCTTTCCGGCTCTTCTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280119762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6478	chr2	175197568	175197588	174332840	174332860	81896	hg19					enhancer	enh				GATCAGGCCGCCTAGAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.873836242									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6479	chr2	175197598	175197618	174332870	174332890	81897	hg19					enhancer	enh				GCCCTCCACCCAGCGTCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050827435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6480	chr2	175197599	175197619	174332871	174332891	81898	hg19					enhancer	enh				GCCTCCACCCAGCGTCCCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.022851421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6481	chr2	175197605	175197625	174332877	174332897	81899	hg19					enhancer	enh				GAGTCCCTGAGGGACGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.282215005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6482	chr2	175197608	175197628	174332880	174332900	81900	hg19					enhancer	enh				GAAAAGTCCCTGAGGGACGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.180087093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6483	chr2	175197609	175197629	174332881	174332901	81901	hg19					enhancer	enh				GAAAAGTCCCTGAGGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328504814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6484	chr2	175197616	175197636	174332888	174332908	81902	hg19					enhancer	enh				GAGGTGTGAAAAGTCCCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021220278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6485	chr2	175197617	175197637	174332889	174332909	81903	hg19					enhancer	enh				GGAGGTGTGAAAAGTCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.060984863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6486	chr2	175197639	175197659	174332911	174332931	81904	hg19					enhancer	enh				GACTGTAGTGGAAATGGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122788887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6487	chr2	175197640	175197660	174332912	174332932	81905	hg19					enhancer	enh				GACTGTAGTGGAAATGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.740816756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6488	chr2	175197643	175197663	174332915	174332935	81906	hg19					enhancer	enh				GGAGACTGTAGTGGAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178326097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6489	chr2	175197644	175197664	174332916	174332936	81907	hg19					enhancer	enh				GGGAGACTGTAGTGGAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.365269396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6490	chr2	175197644	175197664	174332916	174332936	81908	hg19					enhancer	enh				GCATTTCCACTACAGTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.004554552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6491	chr2	175197645	175197665	174332917	174332937	81909	hg19					enhancer	enh				GTGGGAGACTGTAGTGGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.889685221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6492	chr2	175197645	175197665	174332917	174332937	81910	hg19					enhancer	enh				GATTTCCACTACAGTCTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.313105189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6493	chr2	175197646	175197666	174332918	174332938	81911	hg19					enhancer	enh				GCTGGGAGACTGTAGTGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.94482046									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6494	chr2	175197652	175197672	174332924	174332944	81912	hg19					enhancer	enh				GTGTGCCCTGGGAGACTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.052898798									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6495	chr2	175197664	175197684	174332936	174332956	81913	hg19					enhancer	enh				GTCAATGAAGTGCTGTGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.201282617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6496	chr2	175197665	175197685	174332937	174332957	81914	hg19					enhancer	enh				GTCAATGAAGTGCTGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.389739125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6497	chr2	175197690	175197710	174332962	174332982	81915	hg19					enhancer	enh				GAGAGAACGAGAAGGCTCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.666328756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6498	chr2	175197699	175197719	174332971	174332991	81916	hg19					enhancer	enh				GCAGAGGAGAAGAGAACGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.030119913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6499	chr2	175197773	175197793	174333045	174333065	81917	hg19					enhancer	enh				GTTAAGGTGGCGAAAGCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.418838157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6500	chr2	175197828	175197848	174333100	174333120	81918	hg19					enhancer	enh				GAAAATACTTTGGCTCAGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.260362324									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6501	chr2	175197829	175197849	174333101	174333121	81919	hg19					enhancer	enh				GTAAAATACTTTGGCTCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.272652543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6502	chr2	175197871	175197891	174333143	174333163	81920	hg19					enhancer	enh				GCACATAGCCCTCCCCACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.208283452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6503	chr2	175197881	175197901	174333153	174333173	81921	hg19					enhancer	enh				GCGCACTCCGTGGGTGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.242212748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6504	chr2	175197885	175197905	174333157	174333177	81922	hg19					enhancer	enh				GCTTGGCGCACTCCGTGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.79833016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6505	chr2	175197886	175197906	174333158	174333178	81923	hg19					enhancer	enh				GTCTTGGCGCACTCCGTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295237726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6506	chr2	175197887	175197907	174333159	174333179	81924	hg19					enhancer	enh				GTCTTGGCGCACTCCGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.218962625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6507	chr2	175197890	175197910	174333162	174333182	81925	hg19					enhancer	enh				GTGCGTCTTGGCGCACTCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.157687297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6508	chr2	175197891	175197911	174333163	174333183	81926	hg19					enhancer	enh				GTGCGTCTTGGCGCACTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452748192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6509	chr2	175197893	175197913	174333165	174333185	81927	hg19					enhancer	enh				GAGTGCGCCAAGACGCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.21527393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6510	chr2	175197903	175197923	174333175	174333195	81928	hg19					enhancer	enh				GATGGAGCCTGGGTGCGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.08266123									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6511	chr2	175197905	175197925	174333177	174333197	81929	hg19					enhancer	enh				GACGCACCCAGGCTCCATCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.198566559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6512	chr2	175197906	175197926	174333178	174333198	81930	hg19					enhancer	enh				GCGCACCCAGGCTCCATCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.379422756									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6513	chr2	175197913	175197933	174333185	174333205	81931	hg19					enhancer	enh				GTCGGCCCTGTGATGGAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.244664503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6514	chr2	175197914	175197934	174333186	174333206	81932	hg19					enhancer	enh				GCTCGGCCCTGTGATGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.577727141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6515	chr2	175197921	175197941	174333193	174333213	81933	hg19					enhancer	enh				GCGCTGCTCTCGGCCCTGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.49225223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6516	chr2	175197927	175197947	174333199	174333219	81934	hg19					enhancer	enh				GGCCGAGAGCAGCGCCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.250434164									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6517	chr2	175197932	175197952	174333204	174333224	81935	hg19					enhancer	enh				GACCAGAGTGGCGCTGCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.083424223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6518	chr2	175197939	175197959	174333211	174333231	81936	hg19					enhancer	enh				GCGCCACTCTGGTCGTACTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.20806989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6519	chr2	175197944	175197964	174333216	174333236	81937	hg19					enhancer	enh				GACCCAAAAGTACGACCAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043203462									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6520	chr2	175197962	175197982	174333234	174333254	81938	hg19					enhancer	enh				GTCAAGAGATCTTGCAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.100162735									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6521	chr2	175197979	175197999	174333251	174333271	81939	hg19					enhancer	enh				GAAGAGGAGAGAAAACACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.596705906									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6522	chr2	175198010	175198030	174333282	174333302	81940	hg19					enhancer	enh				GCACATCCTTGTCACTTGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.279042267									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6523	chr2	175198012	175198032	174333284	174333304	81941	hg19					enhancer	enh				GCGGTGCAAGTGACAAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.094775198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6524	chr2	175198018	175198038	174333290	174333310	81942	hg19					enhancer	enh				GCGGAGCCGGTGCAAGTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.542076443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6525	chr2	175198032	175198052	174333304	174333324	81943	hg19					enhancer	enh				GACGACGAGTTGTCGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.600997174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6526	chr2	175198038	175198058	174333310	174333330	81944	hg19					enhancer	enh				GTGCAAACGACGAGTTGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.125015642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6527	chr2	175198041	175198061	174333313	174333333	81945	hg19					enhancer	enh				GCAACTCGTCGTTTGCACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.04243881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6528	chr2	175198042	175198062	174333314	174333334	81946	hg19					enhancer	enh				GAACTCGTCGTTTGCACCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.230471449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6529	chr2	175198047	175198067	174333319	174333339	81947	hg19					enhancer	enh				GTCGTTTGCACCCGAGGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.095894235									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6530	chr2	175198048	175198068	174333320	174333340	81948	hg19					enhancer	enh				GTCGTTTGCACCCGAGGGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.569773306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6531	chr2	175198049	175198069	174333321	174333341	81949	hg19					enhancer	enh				GCGTTTGCACCCGAGGGTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.06534998									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6532	chr2	175198053	175198073	174333325	174333345	81950	hg19					enhancer	enh				GTGCACCCGAGGGTTTGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.671502776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6533	chr2	175198060	175198080	174333332	174333352	81951	hg19					enhancer	enh				GACTACCAACCCCAAACCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.294368076									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6534	chr2	175198061	175198081	174333333	174333353	81952	hg19					enhancer	enh				GAACTACCAACCCCAAACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.549770343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6535	chr2	175198093	175198113	174333365	174333385	81953	hg19					enhancer	enh				GTTTCCTAAGAAGCAGGGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.329838425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6536	chr2	175198099	175198119	174333371	174333391	81954	hg19					enhancer	enh				GAAACCCACACCCTGCTTCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.726464194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6537	chr2	175198101	175198121	174333373	174333393	81955	hg19					enhancer	enh				GAAGCAGGGTGTGGGTTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.099412897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6538	chr2	175198102	175198122	174333374	174333394	81956	hg19					enhancer	enh				GAAGCAGGGTGTGGGTTTAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.225235453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6539	chr2	175198132	175198152	174333404	174333424	81957	hg19					enhancer	enh				GCTATATTAAAACCAGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.296253796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6540	chr2	175198143	175198163	174333415	174333435	81958	hg19					enhancer	enh				GCCAGTGCCCAGGTCTGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003704119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6541	chr2	175198144	175198164	174333416	174333436	81959	hg19					enhancer	enh				GCAGTGCCCAGGTCTGCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.044208191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6542	chr2	175198146	175198166	174333418	174333438	81960	hg19					enhancer	enh				GCCTCGGGCAGACCTGGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.025639286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6543	chr2	175198150	175198170	174333422	174333442	81961	hg19					enhancer	enh				GCCAGGTCTGCCCGAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196821633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6544	chr2	175198152	175198172	174333424	174333444	81962	hg19					enhancer	enh				GCAGCGCCCTCGGGCAGACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.280971303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6545	chr2	175198153	175198173	174333425	174333445	81963	hg19					enhancer	enh				GCCAGCGCCCTCGGGCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.08362618									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6546	chr2	175198159	175198179	174333431	174333451	81964	hg19					enhancer	enh				GCCCGAGGGCGCTGGTATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.561951606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6547	chr2	175198162	175198182	174333434	174333454	81965	hg19					enhancer	enh				GCCAGAAATACCAGCGCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.420542092									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6548	chr2	175198163	175198183	174333435	174333455	81966	hg19					enhancer	enh				GACCAGAAATACCAGCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.092723153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6549	chr2	175198177	175198197	174333449	174333469	81967	hg19					enhancer	enh				GTCTGGTTCAAAAACAGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.017275648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6550	chr2	175198186	175198206	174333458	174333478	81968	hg19					enhancer	enh				GAAAACAGCTTCTGGCTACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.342924021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6551	chr2	175198237	175198257	174333509	174333529	81969	hg19					enhancer	enh				GAGAAAAACAAGCAGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.068604625									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6552	chr2	175198244	175198264	174333516	174333536	81970	hg19					enhancer	enh				GACAAGCAGGTCAGCGGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.214022838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6553	chr2	175198245	175198265	174333517	174333537	81971	hg19					enhancer	enh				GCAAGCAGGTCAGCGGTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.149994719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6554	chr2	175198246	175198266	174333518	174333538	81972	hg19					enhancer	enh				GAAGCAGGTCAGCGGTTGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.925355499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6555	chr2	175198247	175198267	174333519	174333539	81973	hg19					enhancer	enh				GAGCAGGTCAGCGGTTGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327950647									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6556	chr2	175198266	175198286	174333538	174333558	81974	hg19					enhancer	enh				GGGGACTCGAAGACGCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.512310443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6557	chr2	175198277	175198297	174333549	174333569	81975	hg19					enhancer	enh				GACGCACCCTGGTCTGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.062459831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6558	chr2	175198286	175198306	174333558	174333578	81976	hg19					enhancer	enh				GAGGCGTCCTCAAGCAGACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.790068357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6559	chr2	175198287	175198307	174333559	174333579	81977	hg19					enhancer	enh				GAGGCGTCCTCAAGCAGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.425114225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6560	chr2	175198306	175198326	174333578	174333598	81978	hg19					enhancer	enh				GACCTTGTCAGTGTGAAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.614445769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6561	chr2	175198308	175198328	174333580	174333600	81979	hg19					enhancer	enh				GTTTCACACTGACAAGGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.074307586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6562	chr2	175198311	175198331	174333583	174333603	81980	hg19					enhancer	enh				GCACACTGACAAGGTCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.242586817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6563	chr2	175198319	175198339	174333591	174333611	81981	hg19					enhancer	enh				GCAAGGTCCAGGGAGGACTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.062132673									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6564	chr2	175198328	175198348	174333600	174333620	81982	hg19					enhancer	enh				GAAGCATCCTGAAGTCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.303117611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6565	chr2	175198343	175198363	174333615	174333635	81983	hg19					enhancer	enh				GTGCTTCCAGCCTGCAAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.400209079									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6566	chr2	175198359	175198379	174333631	174333651	81984	hg19					enhancer	enh				GAATGTGGAAGCGCCCACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.163407965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6567	chr2	175198364	175198384	174333636	174333656	81985	hg19					enhancer	enh				GGAAGCGCCCACGTGTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.414450943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6568	chr2	175198374	175198394	174333646	174333666	81986	hg19					enhancer	enh				GCGGAGGACCAGGCCACACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.173759971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6569	chr2	175198375	175198395	174333647	174333667	81987	hg19					enhancer	enh				GCGGAGGACCAGGCCACACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.056899649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6570	chr2	175198380	175198400	174333652	174333672	81988	hg19					enhancer	enh				GGCCTGGTCCTCCGCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.005089133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6571	chr2	175198381	175198401	174333653	174333673	81989	hg19					enhancer	enh				GCCTGGTCCTCCGCCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.537817668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6572	chr2	175198391	175198411	174333663	174333683	81990	hg19					enhancer	enh				GACTTTCACCCGGGAGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.043909465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6573	chr2	175198393	175198413	174333665	174333685	81991	hg19					enhancer	enh				GCCCTCCCGGGTGAAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.132863831									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6574	chr2	175198394	175198414	174333666	174333686	81992	hg19					enhancer	enh				GAGGACTTTCACCCGGGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.381570886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6575	chr2	175198397	175198417	174333669	174333689	81993	hg19					enhancer	enh				GTCCAGGACTTTCACCCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.72934727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6576	chr2	175198398	175198418	174333670	174333690	81994	hg19					enhancer	enh				GCTCCAGGACTTTCACCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.092318285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6577	chr2	175198401	175198421	174333673	174333693	81995	hg19					enhancer	enh				GTCTCTCCAGGACTTTCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.286199658									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6578	chr2	175198402	175198422	174333674	174333694	81996	hg19					enhancer	enh				GATCTCTCCAGGACTTTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.127104819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6579	chr2	175198406	175198426	174333678	174333698	81997	hg19					enhancer	enh				GAAAGTCCTGGAGAGATTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.323092305									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6580	chr2	175198407	175198427	174333679	174333699	81998	hg19					enhancer	enh				GAAGTCCTGGAGAGATTTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.955858564									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6581	chr2	175198414	175198434	174333686	174333706	81999	hg19					enhancer	enh				GCGCGCCCGAGAAATCTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.262215819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6582	chr2	175198425	175198445	174333697	174333717	82000	hg19					enhancer	enh				GTCGGGCGCGTCCGTGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.280137996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6583	chr2	175198426	175198446	174333698	174333718	82001	hg19					enhancer	enh				GCGGGCGCGTCCGTGAAAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.126822854									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6584	chr2	175198435	175198455	174333707	174333727	82002	hg19					enhancer	enh				GCCGTGAAAGCAGGGCACTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.128826954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6585	chr2	175198436	175198456	174333708	174333728	82003	hg19					enhancer	enh				GCGTGAAAGCAGGGCACTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.32218396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6586	chr2	175198437	175198457	174333709	174333729	82004	hg19					enhancer	enh				GTGAAAGCAGGGCACTAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.872284315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6587	chr2	175198438	175198458	174333710	174333730	82005	hg19					enhancer	enh				GCCATTAGTGCCCTGCTTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.36461612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6588	chr2	175198472	175198492	174333744	174333764	82006	hg19					enhancer	enh				GAAAACAGCGCACTTGCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.179321054									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6589	chr2	175198485	175198505	174333757	174333777	82007	hg19					enhancer	enh				GTGCCCTACGGACGAGCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045115762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6590	chr2	175198490	175198510	174333762	174333782	82008	hg19					enhancer	enh				GGCCTAGAGGCTCGTCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11452619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6591	chr2	175198491	175198511	174333763	174333783	82009	hg19					enhancer	enh				GGGCCTAGAGGCTCGTCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.024741915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6592	chr2	175198491	175198511	174333763	174333783	82010	hg19					enhancer	enh				GACGGACGAGCCTCTAGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.26679088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6593	chr2	175198494	175198514	174333766	174333786	82011	hg19					enhancer	enh				GACGAGCCTCTAGGCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.379323252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6594	chr2	175198499	175198519	174333771	174333791	82012	hg19					enhancer	enh				GCCTCTAGGCCCTGGTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.011120402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6595	chr2	175198503	175198523	174333775	174333795	82013	hg19					enhancer	enh				GTCCAGACCACCAGGGCCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.510085582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6596	chr2	175198504	175198524	174333776	174333796	82014	hg19					enhancer	enh				GTAGGCCCTGGTGGTCTGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.042673865									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6597	chr2	175198505	175198525	174333777	174333797	82015	hg19					enhancer	enh				GAGGCCCTGGTGGTCTGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.00145154									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6598	chr2	175198511	175198531	174333783	174333803	82016	hg19					enhancer	enh				GACTCCCATTCCAGACCACCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.128604642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6599	chr2	175198512	175198532	174333784	174333804	82017	hg19					enhancer	enh				GCACTCCCATTCCAGACCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.885155836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6600	chr2	175198543	175198563	174333815	174333835	82018	hg19					enhancer	enh				GGACAAGAAAACTCCACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.15135577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6601	chr2	175198559	175198579	174333831	174333851	82019	hg19					enhancer	enh				GTGTCGCGTTTCATCCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.046655487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6602	chr2	175198572	175198592	174333844	174333864	82020	hg19					enhancer	enh				GCGCGACATGCAAATCTTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.309863727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6603	chr2	175198573	175198593	174333845	174333865	82021	hg19					enhancer	enh				GCGACATGCAAATCTTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.133861033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6604	chr2	175198609	175198629	174333881	174333901	82022	hg19					enhancer	enh				GCGAGCAAGCTGCAGCTTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043126552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6605	chr2	175198611	175198631	174333883	174333903	82023	hg19					enhancer	enh				GCGCTGAAGCTGCAGCTTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.41398889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6606	chr2	175198612	175198632	174333884	174333904	82024	hg19					enhancer	enh				GCAAGCTGCAGCTTCAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.090169669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6607	chr2	175198615	175198635	174333887	174333907	82025	hg19					enhancer	enh				GAGCTGCAGCTTCAGCGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.149616828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6608	chr2	175198618	175198638	174333890	174333910	82026	hg19					enhancer	enh				GTGCAGCTTCAGCGGAGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.060386589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6609	chr2	175198643	175198663	174333915	174333935	82027	hg19					enhancer	enh				GGGGCGGACGCCGCTCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.020086399									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6610	chr2	175198656	175198676	174333928	174333948	82028	hg19					enhancer	enh				GAAACAGAGACCGGCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04845775									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6611	chr2	175198682	175198702	174333954	174333974	82029	hg19					enhancer	enh				GTGTTACAGTGAGAAAATAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.018069001									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6612	chr2	175198704	175198724	174333976	174333996	82030	hg19					enhancer	enh				GCTTCGTGCAGCGTGTTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.106061534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6613	chr2	175198747	175198767	174334019	174334039	82031	hg19					enhancer	enh				GTGCCAGCCCACAGCAAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.116741104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6614	chr2	175198768	175198788	174334040	174334060	82032	hg19					enhancer	enh				GGATGTGCTGATTATCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.081875741									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6615	chr2	175198769	175198789	174334041	174334061	82033	hg19					enhancer	enh				GGGATGTGCTGATTATCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005140943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6616	chr2	175198789	175198809	174334061	174334081	82034	hg19					enhancer	enh				GTCAAATATGACTAAACAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.37018963									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6617	chr2	175198790	175198810	174334062	174334082	82035	hg19					enhancer	enh				GTGTCAAATATGACTAAACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.936018452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6618	chr2	175198802	175198822	174334074	174334094	82036	hg19					enhancer	enh				GATTTGACAACTGGGTTAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.852041493									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6619	chr2	175198816	175198836	174334088	174334108	82037	hg19					enhancer	enh				GTTAACCTGGTATCTAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.64034637									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6620	chr2	175198823	175198843	174334095	174334115	82038	hg19					enhancer	enh				GTTCGCCAGCGCTTAGATACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.273821431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6621	chr2	175198832	175198852	174334104	174334124	82039	hg19					enhancer	enh				GCGCTGGCGAAACCGTACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.295552642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6622	chr2	175198833	175198853	174334105	174334125	82040	hg19					enhancer	enh				GCGCTGGCGAAACCGTACAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.381334408									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6623	chr2	175198847	175198867	174334119	174334139	82041	hg19					enhancer	enh				GAATTGAGGGCACCCTTTGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.057296369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6624	chr2	175198861	175198881	174334133	174334153	82042	hg19					enhancer	enh				GAGGCTTCTGGTGGTAATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.542817098									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6625	chr2	175198862	175198882	174334134	174334154	82043	hg19					enhancer	enh				GAGGCTTCTGGTGGTAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.238396667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6626	chr2	175198871	175198891	174334143	174334163	82044	hg19					enhancer	enh				GCTCACGCTAGAGGCTTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.772499844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6627	chr2	175198871	175198891	174334143	174334163	82045	hg19					enhancer	enh				GCCAGAAGCCTCTAGCGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.470439405									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6628	chr2	175198874	175198894	174334146	174334166	82046	hg19					enhancer	enh				GCCACTCACGCTAGAGGCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.161400411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6629	chr2	175198881	175198901	174334153	174334173	82047	hg19					enhancer	enh				GACAAGTGCCACTCACGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.032454866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6630	chr2	175198890	175198910	174334162	174334182	82048	hg19					enhancer	enh				GTGGCACTTGTATTACCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.40319304									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6631	chr2	175198891	175198911	174334163	174334183	82049	hg19					enhancer	enh				GTGGCACTTGTATTACCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159889635									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6632	chr2	175198898	175198918	174334170	174334190	82050	hg19					enhancer	enh				GTGTATTACCCCCCGGGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.035226009									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6633	chr2	175198908	175198928	174334180	174334200	82051	hg19					enhancer	enh				GCTCTGGCCTCTGACCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.153359633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6634	chr2	175198909	175198929	174334181	174334201	82052	hg19					enhancer	enh				GCGCTCTGGCCTCTGACCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.099234585									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6635	chr2	175198910	175198930	174334182	174334202	82053	hg19					enhancer	enh				GTCGCTCTGGCCTCTGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119368845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6636	chr2	175198911	175198931	174334183	174334203	82054	hg19					enhancer	enh				GTCGCTCTGGCCTCTGACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.668092986									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6637	chr2	175198912	175198932	174334184	174334204	82055	hg19					enhancer	enh				GTGTCGCTCTGGCCTCTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.431800689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6638	chr2	175198915	175198935	174334187	174334207	82056	hg19					enhancer	enh				GCAGAGGCCAGAGCGACAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.795538365									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6639	chr2	175198934	175198954	174334206	174334226	82057	hg19					enhancer	enh				GTAGGAAGTCACTTACACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.033992532									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6640	chr2	175198935	175198955	174334207	174334227	82058	hg19					enhancer	enh				GAGGAAGTCACTTACACCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090342633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6641	chr2	175198936	175198956	174334208	174334228	82059	hg19					enhancer	enh				GGAAGTCACTTACACCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.192901039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6642	chr2	175198937	175198957	174334209	174334229	82060	hg19					enhancer	enh				GAAGTCACTTACACCGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156951139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6643	chr2	175198938	175198958	174334210	174334230	82061	hg19					enhancer	enh				GAAGTCACTTACACCGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.263484113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6644	chr2	175198944	175198964	174334216	174334236	82062	hg19					enhancer	enh				GCTTACACCGCTGGGGGGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.6934452									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6645	chr2	175198947	175198967	174334219	174334239	82063	hg19					enhancer	enh				GACACCGCTGGGGGGAAATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.019695173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6646	chr2	175198948	175198968	174334220	174334240	82064	hg19					enhancer	enh				GCACCGCTGGGGGGAAATGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.612813666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6647	chr2	175198953	175198973	174334225	174334245	82065	hg19					enhancer	enh				GATCCCGCCATTTCCCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.387034232									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6648	chr2	175198958	175198978	174334230	174334250	82066	hg19					enhancer	enh				GGGAAATGGCGGGATGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.578369161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6649	chr2	175198965	175198985	174334237	174334257	82067	hg19					enhancer	enh				GGCGGGATGCAGCAGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.13426684									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6650	chr2	175198985	175199005	174334257	174334277	82068	hg19					enhancer	enh				GAGGCCCTCCCAACAAATCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.458115703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6651	chr2	175198986	175199006	174334258	174334278	82069	hg19					enhancer	enh				GACAGATTTGTTGGGAGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.010577315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6652	chr2	175198992	175199012	174334264	174334284	82070	hg19					enhancer	enh				GACATCCACAGATTTGTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.229915375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6653	chr2	175198996	175199016	174334268	174334288	82071	hg19					enhancer	enh				GATCTACATCCACAGATTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299576323									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6654	chr2	175199006	175199026	174334278	174334298	82072	hg19					enhancer	enh				GGATGTAGATCTGTACAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.519360577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6655	chr2	175199025	175199045	174334297	174334317	82073	hg19					enhancer	enh				GAGGCCTATTTCGCTCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.080569173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6656	chr2	175199028	175199048	174334300	174334320	82074	hg19					enhancer	enh				GCCTATTTCGCTCCTCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.023483765									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6657	chr2	175199032	175199052	174334304	174334324	82075	hg19					enhancer	enh				GTCCTCCGAGAGGAGCGAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.55612668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6658	chr2	175199043	175199063	174334315	174334335	82076	hg19					enhancer	enh				GAAGGGACAGCTCCTCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.322848077									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6659	chr2	175199069	175199089	174334341	174334361	82077	hg19					enhancer	enh				GTCACAGTTATACTGGGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.676631562									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6660	chr2	175199070	175199090	174334342	174334362	82078	hg19					enhancer	enh				GCTCACAGTTATACTGGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.522496928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6661	chr2	175199071	175199091	174334343	174334363	82079	hg19					enhancer	enh				GTCTCACAGTTATACTGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.11508605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6662	chr2	175199072	175199092	174334344	174334364	82080	hg19					enhancer	enh				GCTCTCACAGTTATACTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.518366381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6663	chr2	175199075	175199095	174334347	174334367	82081	hg19					enhancer	enh				GTCACTCTCACAGTTATACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.743608039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6664	chr2	175199087	175199107	174334359	174334379	82082	hg19					enhancer	enh				GAGAGTGAAATTGAATCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.325092265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6665	chr2	175199094	175199114	174334366	174334386	82083	hg19					enhancer	enh				GAAATTGAATCTAGTGGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274880192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6666	chr2	175199100	175199120	174334372	174334392	82084	hg19					enhancer	enh				GAATCTAGTGGAATAAGGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.871492689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6667	chr2	175199101	175199121	174334373	174334393	82085	hg19					enhancer	enh				GATCTAGTGGAATAAGGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.096522614									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6668	chr2	175199184	175199204	174334456	174334476	82086	hg19					enhancer	enh				GTGTTCTGTAGGCAAAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.356772765									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6669	chr2	175199199	175199219	174334471	174334491	82087	hg19					enhancer	enh				GAAGCCTGGACACACAAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.318281796									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6670	chr2	175199200	175199220	174334472	174334492	82088	hg19					enhancer	enh				GAGCCTGGACACACAAAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.096779689									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6671	chr2	175199205	175199225	174334477	174334497	82089	hg19					enhancer	enh				GAGCCCTCACTTTGTGTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.363259555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6672	chr2	175199223	175199243	174334495	174334515	82090	hg19					enhancer	enh				GCTCACATTTCCGTCTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.121656623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6673	chr2	175199233	175199253	174334505	174334525	82091	hg19					enhancer	enh				GCGTCTCCACTTGGGCCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39603467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6674	chr2	175199235	175199255	174334507	174334527	82092	hg19					enhancer	enh				GCAGCAGGGCCCAAGTGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006566843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6675	chr2	175199238	175199258	174334510	174334530	82093	hg19					enhancer	enh				GCCACTTGGGCCCTGCTGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023359766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6676	chr2	175199239	175199259	174334511	174334531	82094	hg19					enhancer	enh				GCACTTGGGCCCTGCTGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.185891392									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6677	chr2	175199241	175199261	174334513	174334533	82095	hg19					enhancer	enh				GCCGCACCAGCAGGGCCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.068469415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6678	chr2	175199249	175199269	174334521	174334541	82096	hg19					enhancer	enh				GCTGCTGGTGCGGGCTGTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.203272509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6679	chr2	175199250	175199270	174334522	174334542	82097	hg19					enhancer	enh				GTGCTGGTGCGGGCTGTGTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.910491058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6680	chr2	175199250	175199270	174334522	174334542	82098	hg19					enhancer	enh				GAGACACAGCCCGCACCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428309828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6681	chr2	175199251	175199271	174334523	174334543	82099	hg19					enhancer	enh				GCAGACACAGCCCGCACCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.540995058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6682	chr2	175199286	175199306	174334558	174334578	82100	hg19					enhancer	enh				GCCTGCCTCCTTTCCTACAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.529723133									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6683	chr2	175199287	175199307	174334559	174334579	82101	hg19					enhancer	enh				GCTGCCTCCTTTCCTACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.059261395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6684	chr2	175199288	175199308	174334560	174334580	82102	hg19					enhancer	enh				GTGCCTCCTTTCCTACAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.028391572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6685	chr2	175199289	175199309	174334561	174334581	82103	hg19					enhancer	enh				GCCACTTGTAGGAAAGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.077714177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6686	chr2	175199293	175199313	174334565	174334585	82104	hg19					enhancer	enh				GCTCCCCACTTGTAGGAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.030428108									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6687	chr2	175199296	175199316	174334568	174334588	82105	hg19					enhancer	enh				GCGACTCCCCACTTGTAGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.368594176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6688	chr2	175199299	175199319	174334571	174334591	82106	hg19					enhancer	enh				GCTACAAGTGGGGAGTCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.125677881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6689	chr2	175199301	175199321	174334573	174334593	82107	hg19					enhancer	enh				GCTACTCGACTCCCCACTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.048626082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6690	chr2	175199328	175199348	174334600	174334620	82108	hg19					enhancer	enh				GAGCCCTAACTTGCAACATCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.018511091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6691	chr2	175199329	175199349	174334601	174334621	82109	hg19					enhancer	enh				GCCCTAACTTGCAACATCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.785477774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6692	chr2	175199330	175199350	174334602	174334622	82110	hg19					enhancer	enh				GCCCTAACTTGCAACATCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.187985909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6693	chr2	175199333	175199353	174334605	174334625	82111	hg19					enhancer	enh				GTAACTTGCAACATCTCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.194602378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6694	chr2	175199333	175199353	174334605	174334625	82112	hg19					enhancer	enh				GCCCCGAGATGTTGCAAGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119473167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6695	chr2	175199334	175199354	174334606	174334626	82113	hg19					enhancer	enh				GACCCCGAGATGTTGCAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.073167971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6696	chr2	175199390	175199410	174334662	174334682	82114	hg19					enhancer	enh				GATTGGTACTTAAACCTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253017435									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6697	chr2	175199406	175199426	174334678	174334698	82115	hg19					enhancer	enh				GTTACACTCACGCACCAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.42295136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6698	chr2	175199479	175199499	174334751	174334771	82116	hg19					enhancer	enh				GTAGTGGGGGATACTTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045833101									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6699	chr2	175199480	175199500	174334752	174334772	82117	hg19					enhancer	enh				GAGTAGTGGGGGATACTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.34057165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6700	chr2	175199481	175199501	174334753	174334773	82118	hg19					enhancer	enh				GAGTAGTGGGGGATACTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342706754									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6701	chr2	175199482	175199502	174334754	174334774	82119	hg19					enhancer	enh				GGAGTAGTGGGGGATACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.440760624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6702	chr2	175199494	175199514	174334766	174334786	82120	hg19					enhancer	enh				GACTACTCCCCCCCACCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.035014672									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6703	chr2	175199511	175199531	174334783	174334803	82121	hg19					enhancer	enh				GTCAGCTAGCTAGGGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.051999074									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6704	chr2	175199512	175199532	174334784	174334804	82122	hg19					enhancer	enh				GTCAGCTAGCTAGGGCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048656932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6705	chr2	175199513	175199533	174334785	174334805	82123	hg19					enhancer	enh				GAGTCAGCTAGCTAGGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.189609823									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6706	chr2	175199514	175199534	174334786	174334806	82124	hg19					enhancer	enh				GAAGTCAGCTAGCTAGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.21311652									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6707	chr2	175199517	175199537	174334789	174334809	82125	hg19					enhancer	enh				GCCCTAGCTAGCTGACTTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.545731264									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6708	chr2	175199520	175199540	174334792	174334812	82126	hg19					enhancer	enh				GCCAGTCAAGTCAGCTAGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.568748025									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6709	chr2	175199521	175199541	174334793	174334813	82127	hg19					enhancer	enh				GCCAGTCAAGTCAGCTAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.194469478									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6710	chr2	175199527	175199547	174334799	174334819	82128	hg19					enhancer	enh				GCTGACTTGACTGGCACGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043007482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6711	chr2	175199528	175199548	174334800	174334820	82129	hg19					enhancer	enh				GTGACTTGACTGGCACGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.44310762									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6712	chr2	175199535	175199555	174334807	174334827	82130	hg19					enhancer	enh				GACTGGCACGCGCCGGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.171285366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6713	chr2	175199536	175199556	174334808	174334828	82131	hg19					enhancer	enh				GCTGGCACGCGCCGGGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.368544523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6714	chr2	175199541	175199561	174334813	174334833	82132	hg19					enhancer	enh				GACGCGCCGGGAGCCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.487334453									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6715	chr2	175199542	175199562	174334814	174334834	82133	hg19					enhancer	enh				GCGCGCCGGGAGCCCGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.206881541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6716	chr2	175199549	175199569	174334821	174334841	82134	hg19					enhancer	enh				GGGGCCCGAGCCCGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.616143884									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6717	chr2	175199550	175199570	174334822	174334842	82135	hg19					enhancer	enh				GAGCCCGGGCTCGGGCCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.297217005									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6718	chr2	175199556	175199576	174334828	174334848	82136	hg19					enhancer	enh				GCTCCGAGGGGCCCGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.124022677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6719	chr2	175199557	175199577	174334829	174334849	82137	hg19					enhancer	enh				GCGCTCCGAGGGGCCCGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.181581476									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6720	chr2	175199563	175199583	174334835	174334855	82138	hg19					enhancer	enh				GGCCCCTCGGAGCGTCTGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033194572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6721	chr2	175199568	175199588	174334840	174334860	82139	hg19					enhancer	enh				GAGCCAATCAGACGCTCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.250013768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6722	chr2	175199569	175199589	174334841	174334861	82140	hg19					enhancer	enh				GTCGGAGCGTCTGATTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.896955414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6723	chr2	175199569	175199589	174334841	174334861	82141	hg19					enhancer	enh				GCAGCCAATCAGACGCTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.251062759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6724	chr2	175199570	175199590	174334842	174334862	82142	hg19					enhancer	enh				GCAGCCAATCAGACGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.090890364									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6725	chr2	175199570	175199590	174334842	174334862	82143	hg19					enhancer	enh				GCGGAGCGTCTGATTGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.438185446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6726	chr2	175199571	175199591	174334843	174334863	82144	hg19					enhancer	enh				GGAGCGTCTGATTGGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.021180492									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6727	chr2	175199580	175199600	174334852	174334872	82145	hg19					enhancer	enh				GATTGGCTGCGGGGCAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.825256266									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6728	chr2	175199602	175199622	174334874	174334894	82146	hg19					enhancer	enh				GAGGGCGCAGGCAGAGCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.274006422									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6729	chr2	175199605	175199625	174334877	174334897	82147	hg19					enhancer	enh				GTGCTCTGCCTGCGCCCTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152612379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6730	chr2	175199606	175199626	174334878	174334898	82148	hg19					enhancer	enh				GCTCTGCCTGCGCCCTCATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.404930194									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6731	chr2	175199613	175199633	174334885	174334905	82149	hg19					enhancer	enh				GCTGCGCCCTCATTGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15614604									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6732	chr2	175199615	175199635	174334887	174334907	82150	hg19					enhancer	enh				GCTCTCGCCCAATGAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.080878774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6733	chr2	175199621	175199641	174334893	174334913	82151	hg19					enhancer	enh				GCTGCGCCTCTCGCCCAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003463117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6734	chr2	175199622	175199642	174334894	174334914	82152	hg19					enhancer	enh				GCTGCGCCTCTCGCCCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.209084169									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6735	chr2	175199638	175199658	174334910	174334930	82153	hg19					enhancer	enh				GCAGCCAGCGGCACTTCAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.544931688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6736	chr2	175199639	175199659	174334911	174334931	82154	hg19					enhancer	enh				GAGCCAGCGGCACTTCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.696309451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6737	chr2	175199644	175199664	174334916	174334936	82155	hg19					enhancer	enh				GCACCCGCTTTGAAGTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.479025765									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6738	chr2	175199656	175199676	174334928	174334948	82156	hg19					enhancer	enh				GAGCGGGTGCTCCTCGCACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.349538432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6739	chr2	175199669	175199689	174334941	174334961	82157	hg19					enhancer	enh				GCTAAACTCAGCCTAAGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.250803649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6740	chr2	175199670	175199690	174334942	174334962	82158	hg19					enhancer	enh				GCACTTAGGCTGAGTTTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153668171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6741	chr2	175199673	175199693	174334945	174334965	82159	hg19					enhancer	enh				GCTTAGGCTGAGTTTAGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.166990393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6742	chr2	175199674	175199694	174334946	174334966	82160	hg19					enhancer	enh				GTTAGGCTGAGTTTAGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.265939656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6743	chr2	175199681	175199701	174334953	174334973	82161	hg19					enhancer	enh				GAGTTTAGCCGGCGGGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.117524135									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6744	chr2	175199692	175199712	174334964	174334984	82162	hg19					enhancer	enh				GAGCGGACTCCAGGCTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.216215268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6745	chr2	175199692	175199712	174334964	174334984	82163	hg19					enhancer	enh				GCGGGAGCCTGGAGTCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.112381129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6746	chr2	175199702	175199722	174334974	174334994	82164	hg19					enhancer	enh				GCTCGTGCCGAGCGGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.049401198									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6747	chr2	175199703	175199723	174334975	174334995	82165	hg19					enhancer	enh				GAGTCCGCTCGGCACGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.328646298									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6748	chr2	175199704	175199724	174334976	174334996	82166	hg19					enhancer	enh				GAGTCCGCTCGGCACGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148219413									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6749	chr2	175199705	175199725	174334977	174334997	82167	hg19					enhancer	enh				GTCCGCTCGGCACGAGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.242336883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6750	chr2	175199710	175199730	174334982	174335002	82168	hg19					enhancer	enh				GTCCCCGCGCTCGTGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005138409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6751	chr2	175199740	175199760	174335012	174335032	82169	hg19					enhancer	enh				GAAAACTGCTTGGGTCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.524400436									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6752	chr2	175199750	175199770	174335022	174335042	82170	hg19					enhancer	enh				GCTGCTCGGAAAAACTGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.000603645									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6753	chr2	175199751	175199771	174335023	174335043	82171	hg19					enhancer	enh				GGCTGCTCGGAAAAACTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104236677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6754	chr2	175199764	175199784	174335036	174335056	82172	hg19					enhancer	enh				GGCTGAGCCTGGCGGCTGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.44576506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6755	chr2	175199792	175199812	174335064	174335084	82173	hg19					enhancer	enh				GTCTGGCTGCGCAGCGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.179851757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6756	chr2	175199793	175199813	174335065	174335085	82174	hg19					enhancer	enh				GCTCTGGCTGCGCAGCGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.348117506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6757	chr2	175199797	175199817	174335069	174335089	82175	hg19					enhancer	enh				GAGGTCTCTGGCTGCGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.767188185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6758	chr2	175199801	175199821	174335073	174335093	82176	hg19					enhancer	enh				GCGCAGCCAGAGACCTGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121297353									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6759	chr2	175199810	175199830	174335082	174335102	82177	hg19					enhancer	enh				GACGTGGCCATAGCAGGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.337629372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6760	chr2	175199817	175199837	174335089	174335109	82178	hg19					enhancer	enh				GCTATGGCCACGTCTATACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082186972									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6761	chr2	175199817	175199837	174335089	174335109	82179	hg19					enhancer	enh				GAGTATAGACGTGGCCATAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.835234178									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6762	chr2	175199818	175199838	174335090	174335110	82180	hg19					enhancer	enh				GCTATGGCCACGTCTATACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.825957341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6763	chr2	175199819	175199839	174335091	174335111	82181	hg19					enhancer	enh				GTATGGCCACGTCTATACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.334219228									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97135	chr2	175199827	175199847	174335099	174335119	82182	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACTTACCCCGAGTATAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.469769369	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199835	175199855	174335107	174335127	82183	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTCGGGGTAAGTCGCAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.768296528	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199882	175199902	174335154	174335174	82184	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCATAACGAAAAATTACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.25009585	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199900	175199920	174335172	174335192	82185	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTTCTGGGGTCTGCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.128638128	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199922	175199942	174335194	174335214	82186	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCTAGCAGCAACAGTTTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.203344491	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199973	175199993	174335245	174335265	82187	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAAAATCAGTCCCAGAAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.074024673	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199996	175200016	174335268	174335288	82188	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTCTGGGTTCCAAAAACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.153692495	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175199998	175200018	174335270	174335290	82189	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTTTCTGGGTTCCAAAAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.172359551	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200014	175200034	174335286	174335306	82190	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAAGATGCCTTTGCAAGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59627757	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200040	175200060	174335312	174335332	82191	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAAAAGGACTTGATTAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.311303705	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200063	175200083	174335335	174335355	82192	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTGGTTTCAAAAAAAAGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310599083	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200100	175200120	174335372	174335392	82193	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GATGGGGTATAAATCACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.201942824	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200101	175200121	174335373	174335393	82194	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGATGGGGTATAAATCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.719319092	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200102	175200122	174335374	174335394	82195	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGGATGGGGTATAAATCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.053609655	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200113	175200133	174335385	174335405	82196	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCCATCCCCCGCATTGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.437975788	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200114	175200134	174335386	174335406	82197	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCATCCCCCGCATTGCTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.005020102	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200115	175200135	174335387	174335407	82198	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCATCCCCCGCATTGCTTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.51510988	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200116	175200136	174335388	174335408	82199	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCAAAGCAATGCGGGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.46874069	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200117	175200137	174335389	174335409	82200	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCAAAGCAATGCGGGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.514460039	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200118	175200138	174335390	174335410	82201	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCCAAAGCAATGCGGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.1865632	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200122	175200142	174335394	174335414	82202	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAATCCCCAAAGCAATGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.212074346	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200123	175200143	174335395	174335415	82203	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAAATCCCCAAAGCAATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.248569515	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200124	175200144	174335396	174335416	82204	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAAAATCCCCAAAGCAATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301859103	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200125	175200145	174335397	174335417	82205	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACAAAATCCCCAAAGCAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.626857155	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200141	175200161	174335413	174335433	82206	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTGTTGCAATTATGCGACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.492515291	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200213	175200233	174335485	174335505	82207	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAATAAACATTTACATTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.267636019	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200241	175200261	174335513	174335533	82208	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCAAAGTCATGGGCGAATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.894218064	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200242	175200262	174335514	174335534	82209	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTCAAAGTCATGGGCGAATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.526996934	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200243	175200263	174335515	174335535	82210	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTTCAAAGTCATGGGCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.260771357	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200251	175200271	174335523	174335543	82211	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGACAGATTTCAAAGTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.045562789	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200252	175200272	174335524	174335544	82212	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGAGACAGATTTCAAAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.529273013	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200277	175200297	174335549	174335569	82213	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAACAATAATCCGAGGATAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.009046441	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200285	175200305	174335557	174335577	82214	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GATTATGAAAACAATAATCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.778927084	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200361	175200381	174335633	174335653	82215	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGTCAAGTCGTAGCCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.638413229	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200362	175200382	174335634	174335654	82216	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGTCAAGTCGTAGCCACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.18818959	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200378	175200398	174335650	174335670	82217	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAACTTGCAGCTCTCCCAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.162851174	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200381	175200401	174335653	174335673	82218	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGAAACTTGCAGCTCTCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.348523904	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200382	175200402	174335654	174335674	82219	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGAAACTTGCAGCTCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.130540296	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200389	175200409	174335661	174335681	82220	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTGCAAGTTTCGCCCGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.112519684	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200401	175200421	174335673	174335693	82221	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCGTCCCTGGCAGCTGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.056466284	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200404	175200424	174335676	174335696	82222	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGAAACAGCTGCCAGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310813623	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200405	175200425	174335677	174335697	82223	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGAAACAGCTGCCAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.038429093	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200409	175200429	174335681	174335701	82224	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGCGGCCGAAACAGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.387112476	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200410	175200430	174335682	174335702	82225	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGGCGGCCGAAACAGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254786057	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200421	175200441	174335693	174335713	82226	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGCCGCCTCCGCCCTCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.405106211	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200430	175200450	174335702	174335722	82227	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAAACACCGGGTGAGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.494877287	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200433	175200453	174335705	174335725	82228	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAACAAACACCGGGTGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.017448407	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200436	175200456	174335708	174335728	82229	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGACAACAAACACCGGGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.539607575	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200437	175200457	174335709	174335729	82230	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGACAACAAACACCGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.879069851	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200442	175200462	174335714	174335734	82231	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCAGAGACAACAAACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.101806966	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200443	175200463	174335715	174335735	82232	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGACCAGAGACAACAAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.452029277	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200471	175200491	174335743	174335763	82233	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCTTCGCGCTTCACCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.02788543	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200472	175200492	174335744	174335764	82234	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCTTCGCGCTTCACCCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.185837747	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200475	175200495	174335747	174335767	82235	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCTTCGGGGTGAAGCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.102711378	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200480	175200500	174335752	174335772	82236	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTTCACCCCGAAGGGCGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.407511546	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200481	175200501	174335753	174335773	82237	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTCACCCCGAAGGGCGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.256193524	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200482	175200502	174335754	174335774	82238	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCACCCCGAAGGGCGACTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.007971632	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200488	175200508	174335760	174335780	82239	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGACCCCAAGTCGCCCTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.340636912	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200489	175200509	174335761	174335781	82240	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGACCCCAAGTCGCCCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.625898117	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200490	175200510	174335762	174335782	82241	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGGGCGACTTGGGGTCTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.821514884	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200490	175200510	174335762	174335782	82242	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGACCCCAAGTCGCCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085243121	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200491	175200511	174335763	174335783	82243	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGGGCGACTTGGGGTCTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.488690817	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200502	175200522	174335774	174335794	82244	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGGTCTTCTGGGAGATGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.511790779	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200509	175200529	174335781	174335801	82245	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTGGGAGATGAGCCGGTTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.039599441	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200524	175200544	174335796	174335816	82246	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTTGGGTTGTCGCCGTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121821653	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200526	175200546	174335798	174335818	82247	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTACGGCGACAACCCAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.046943943	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200533	175200553	174335805	174335825	82248	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACAACCCAAGTCCGGTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057780327	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200537	175200557	174335809	174335829	82249	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCCAAGTCCGGTTGTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.26096371	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200538	175200558	174335810	174335830	82250	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCAAGTCCGGTTGTAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.780131907	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200541	175200561	174335813	174335833	82251	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCTGCCTACAACCGGACTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.348386616	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200542	175200562	174335814	174335834	82252	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCCTGCCTACAACCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.970716084	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200547	175200567	174335819	174335839	82253	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGTTGTAGGCAGGGTTGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.538430942	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200548	175200568	174335820	174335840	82254	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTGCAACCCTGCCTACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.220404575	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200548	175200568	174335820	174335840	82255	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTGTAGGCAGGGTTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.501882882	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200549	175200569	174335821	174335841	82256	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTGTAGGCAGGGTTGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.845113028	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200556	175200576	174335828	174335848	82257	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAGGGTTGCAGCGGGGAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.290399921	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200559	175200579	174335831	174335851	82258	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GGTTGCAGCGGGGAACACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.446884013	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200599	175200619	174335871	174335891	82259	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTCAGCGAAGTGCAACTTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.122727516	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200601	175200621	174335873	174335893	82260	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGAAAGTTGCACTTCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.045556104	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200606	175200626	174335878	174335898	82261	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGTGCAACTTTCCGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.431249695	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200618	175200638	174335890	174335910	82262	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGGCGCCTGGACCTTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.224368141	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200619	175200639	174335891	174335911	82263	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGCGCCTGGACCTTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.167036748	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200621	175200641	174335893	174335913	82264	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGGGCGAAGGTCCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.257317444	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200627	175200647	174335899	174335919	82265	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GATCACCCGGGCGAAGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.244710565	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200633	175200653	174335905	174335925	82266	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGGGGCGATCACCCGGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.336638437	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200639	175200659	174335911	174335931	82267	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGAGCAGGGGCGATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.268625863	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200640	175200660	174335912	174335932	82268	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGAGCAGGGGCGATCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.085845068	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200643	175200663	174335915	174335935	82269	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GATCGCCCCTGCTCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.07445028	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200648	175200668	174335920	174335940	82270	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCCTGCTCCGCGCCCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.056118214	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200651	175200671	174335923	174335943	82271	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGCACCGGGCGCGGAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.243372942	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200652	175200672	174335924	174335944	82272	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGCACCGGGCGCGGAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.540385561	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200653	175200673	174335925	174335945	82273	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGCCGCACCGGGCGCGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.302288146	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200659	175200679	174335931	174335951	82274	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGGAGTCGCCGCACCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.507384853	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200662	175200682	174335934	174335954	82275	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGGTGCGGCGACTCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.278227777	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200663	175200683	174335935	174335955	82276	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGTGCGGCGACTCCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.130010653	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200664	175200684	174335936	174335956	82277	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGCGGAGGAGTCGCCGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.379208417	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200665	175200685	174335937	174335957	82278	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCGCGGAGGAGTCGCCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.423211581	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200670	175200690	174335942	174335962	82279	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGACTCCTCCGCGGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.2325017	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200671	175200691	174335943	174335963	82280	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGACTCCTCCGCGGGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.2644576	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200672	175200692	174335944	174335964	82281	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACTCCTCCGCGGGCGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.054970523	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200679	175200699	174335951	174335971	82282	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCCTCCCCACGCGCCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.362234039	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200682	175200702	174335954	174335974	82283	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCTCCTCCCCACGCGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.270541144	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200707	175200727	174335979	174335999	82284	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGGGAGCCAGGACCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.181155447	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200718	175200738	174335990	174336010	82285	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGCTGCTCCCGGGGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.214227484	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200719	175200739	174335991	174336011	82286	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCCCCCGGGAGCAGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.597742352	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200720	175200740	174335992	174336012	82287	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GACCCCCCGGGAGCAGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.082987006	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200721	175200741	174335993	174336013	82288	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCCCCGGGAGCAGCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.078893133	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200724	175200744	174335996	174336016	82289	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCCCCTGCGGCTGCTCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.197441766	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200725	175200745	174335997	174336017	82290	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCCCCTGCGGCTGCTCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159038614	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200726	175200746	174335998	174336018	82291	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCCCCTGCGGCTGCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.182274403	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200727	175200747	174335999	174336019	82292	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGTCCCCTGCGGCTGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.296082224	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200728	175200748	174336000	174336020	82293	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCGTCCCCTGCGGCTGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.098951223	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200737	175200757	174336009	174336029	82294	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAGGGGACGAGGCTGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.392018174	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200738	175200758	174336010	174336030	82295	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTGAGCAGCCTCGTCCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342159761	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200738	175200758	174336010	174336030	82296	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCAGGGGACGAGGCTGCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.483423864	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200812	175200832	174336084	174336104	82297	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCCCCCATCCCACCCACTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.043043664	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200817	175200837	174336089	174336109	82298	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTTCCTAGAGTGGGTGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.826304799	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200818	175200838	174336090	174336110	82299	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTTCCTAGAGTGGGTGGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.093561401	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200819	175200839	174336091	174336111	82300	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GTCTTCCTAGAGTGGGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.496990838	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200823	175200843	174336095	174336115	82301	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGCTCTTCCTAGAGTGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.391610474	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200824	175200844	174336096	174336116	82302	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCGGCTCTTCCTAGAGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253005063	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200827	175200847	174336099	174336119	82303	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAGCGCGGCTCTTCCTAGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.152574718	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200828	175200848	174336100	174336120	82304	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GCTCTAGGAAGAGCCGCGCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.086789849	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-97135	chr2	175200828	175200848	174336100	174336120	82305	hg19	N/A	N/A	N/A	Enhatls103968	enhancer	enh				GAAGCGCGGCTCTTCCTAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.406936787	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9061
enhrx-lit6764	chr2	175200842	175200862	174336114	174336134	82306	hg19					enhancer	enh				GCGCTTCGGAACGACCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.023267214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6765	chr2	175200843	175200863	174336115	174336135	82307	hg19					enhancer	enh				GAACGGGGTCGTTCCGAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.555024766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6766	chr2	175200851	175200871	174336123	174336143	82308	hg19					enhancer	enh				GAACGACCCCGTTGGCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.21206947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6767	chr2	175200854	175200874	174336126	174336146	82309	hg19					enhancer	enh				GACCCCGTTGGCCATGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.378543957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6768	chr2	175200861	175200881	174336133	174336153	82310	hg19					enhancer	enh				GTCGCCGCCAGCATGGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.280153348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6769	chr2	175200868	175200888	174336140	174336160	82311	hg19					enhancer	enh				GTTGCAGGTCGCCGCCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.425354746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6770	chr2	175200873	175200893	174336145	174336165	82312	hg19					enhancer	enh				GCGGCGACCTGCAACAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.608390657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6771	chr2	175200908	175200928	174336180	174336200	82313	hg19					enhancer	enh				GACTCTGGCAGCGTCGTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.597852918									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6772	chr2	175200909	175200929	174336181	174336201	82314	hg19					enhancer	enh				GACTCTGGCAGCGTCGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.094016529									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6773	chr2	175200924	175200944	174336196	174336216	82315	hg19					enhancer	enh				GTTGGCGAAGGCGCTCGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.327111758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6774	chr2	175200924	175200944	174336196	174336216	82316	hg19					enhancer	enh				GAGTCGAGCGCCTTCGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.297555337									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6775	chr2	175200927	175200947	174336199	174336219	82317	hg19					enhancer	enh				GTCGAGCGCCTTCGCCAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199690849									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6776	chr2	175200937	175200957	174336209	174336229	82318	hg19					enhancer	enh				GTGAAAGCCGCCTTTGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.031146233									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6777	chr2	175200940	175200960	174336212	174336232	82319	hg19					enhancer	enh				GCCAAAGGCGGCTTTCACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.121037048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6778	chr2	175200943	175200963	174336215	174336235	82320	hg19					enhancer	enh				GCCAGGGGTGAAAGCCGCCTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.612922331									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6779	chr2	175200959	175200979	174336231	174336251	82321	hg19					enhancer	enh				GTGGACGAGGAGCGCTTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.009360872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6780	chr2	175200960	175200980	174336232	174336252	82322	hg19					enhancer	enh				GCTGGACGAGGAGCGCTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.47435144									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6781	chr2	175200961	175200981	174336233	174336253	82323	hg19					enhancer	enh				GCTGGACGAGGAGCGCTTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.59293661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6782	chr2	175200969	175200989	174336241	174336261	82324	hg19					enhancer	enh				GTCCTCGTCCAGCTGCAACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.588264612									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6783	chr2	175200973	175200993	174336245	174336265	82325	hg19					enhancer	enh				GCCGAGGTTGCAGCTGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.803583434									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6784	chr2	175200979	175200999	174336251	174336271	82326	hg19					enhancer	enh				GCTGGAGCCGAGGTTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.264419603									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6785	chr2	175200983	175201003	174336255	174336275	82327	hg19					enhancer	enh				GCAACCTCGGCTCCAGCCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.156665437									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6786	chr2	175200984	175201004	174336256	174336276	82328	hg19					enhancer	enh				GAACCTCGGCTCCAGCCTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253614268									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6787	chr2	175200989	175201009	174336261	174336281	82329	hg19					enhancer	enh				GAGCCCGAGAGGCTGGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.117553909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6788	chr2	175200992	175201012	174336264	174336284	82330	hg19					enhancer	enh				GCTCCAGCCTCTCGGGCTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151055152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6789	chr2	175200995	175201015	174336267	174336287	82331	hg19					enhancer	enh				GCAGCCTCTCGGGCTTCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.420167409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6790	chr2	175200997	175201017	174336269	174336289	82332	hg19					enhancer	enh				GCACCGCGAAGCCCGAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.041058618									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6791	chr2	175201001	175201021	174336273	174336293	82333	hg19					enhancer	enh				GTGGCCACCGCGAAGCCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.154381483									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6792	chr2	175201002	175201022	174336274	174336294	82334	hg19					enhancer	enh				GTCGGGCTTCGCGGTGGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.144229116									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6793	chr2	175201003	175201023	174336275	174336295	82335	hg19					enhancer	enh				GCGGGCTTCGCGGTGGCCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.215369911									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6794	chr2	175201004	175201024	174336276	174336296	82336	hg19					enhancer	enh				GGGCTTCGCGGTGGCCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.13241718									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6795	chr2	175201005	175201025	174336277	174336297	82337	hg19					enhancer	enh				GGCTTCGCGGTGGCCACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.001441824									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6796	chr2	175201016	175201036	174336288	174336308	82338	hg19					enhancer	enh				GGCCACCGGGGGCCGTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.085438559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6797	chr2	175201017	175201037	174336289	174336309	82339	hg19					enhancer	enh				GCCACCGGGGGCCGTGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.440561602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6798	chr2	175201021	175201041	174336293	174336313	82340	hg19					enhancer	enh				GCCCGAGCCACGGCCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.24867687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6799	chr2	175201024	175201044	174336296	174336316	82341	hg19					enhancer	enh				GCCGCCCGAGCCACGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.367173964									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6800	chr2	175201031	175201051	174336303	174336323	82342	hg19					enhancer	enh				GCCGCCAGGCCGCCCGAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.765572317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6801	chr2	175201046	175201066	174336318	174336338	82343	hg19					enhancer	enh				GCGGCGCCCGAGCCGCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108220962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6802	chr2	175201064	175201084	174336336	174336356	82344	hg19					enhancer	enh				GCGCCAACAGCGCCTTCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.415316177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6803	chr2	175201066	175201086	174336338	174336358	82345	hg19					enhancer	enh				GCAGGCAGAAGGCGCTGTTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.05041318									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6804	chr2	175201069	175201089	174336341	174336361	82346	hg19					enhancer	enh				GGCCAGGCAGAAGGCGCTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.378373606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6805	chr2	175201101	175201121	174336373	174336393	82347	hg19					enhancer	enh				GCTGCTGAAGGCGGACGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.310144127									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6806	chr2	175201102	175201122	174336374	174336394	82348	hg19					enhancer	enh				GCTGCTGAAGGCGGACGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.079703942									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6807	chr2	175201107	175201127	174336379	174336399	82349	hg19					enhancer	enh				GTCCGCCTTCAGCAGCGACTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.207357184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6808	chr2	175201110	175201130	174336382	174336402	82350	hg19					enhancer	enh				GCCTTCAGCAGCGACTACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.020336763									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6809	chr2	175201111	175201131	174336383	174336403	82351	hg19					enhancer	enh				GCCGTAGTCGCTGCTGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.348496751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6810	chr2	175201114	175201134	174336386	174336406	82352	hg19					enhancer	enh				GCCGCCGTAGTCGCTGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.196805493									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6811	chr2	175201127	175201147	174336399	174336419	82353	hg19					enhancer	enh				GCGGCGGCCTCTTCTCCAACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.502472649									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6812	chr2	175201130	175201150	174336402	174336422	82354	hg19					enhancer	enh				GCGGCCTCTTCTCCAACTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.012898356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6813	chr2	175201136	175201156	174336408	174336428	82355	hg19					enhancer	enh				GCAGCCGCCGAGTTGGAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.458634739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6814	chr2	175201139	175201159	174336411	174336431	82356	hg19					enhancer	enh				GCTCCAACTCGGCGGCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.065541445									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6815	chr2	175201142	175201162	174336414	174336434	82357	hg19					enhancer	enh				GCAACTCGGCGGCTGCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.127202881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6816	chr2	175201144	175201164	174336416	174336436	82358	hg19					enhancer	enh				GCGCCGCGGCAGCCGCCGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.773095567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6817	chr2	175201159	175201179	174336431	174336451	82359	hg19					enhancer	enh				GCACCCCGGCCGCTGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.12113738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6818	chr2	175201166	175201186	174336438	174336458	82360	hg19					enhancer	enh				GAGCGGCCGGGGTGTCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.193815361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6819	chr2	175201169	175201189	174336441	174336461	82361	hg19					enhancer	enh				GGCCGGGGTGTCCCCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.669260387									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6820	chr2	175201173	175201193	174336445	174336465	82362	hg19					enhancer	enh				GGGGTGTCCCCGCAGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.833410527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6821	chr2	175201174	175201194	174336446	174336466	82363	hg19					enhancer	enh				GCGCCTCCTGCGGGGACACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.174864124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6822	chr2	175201176	175201196	174336448	174336468	82364	hg19					enhancer	enh				GTGTCCCCGCAGGAGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.264024608									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6823	chr2	175201183	175201203	174336455	174336475	82365	hg19					enhancer	enh				GCTGGCCACCCGCCTCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.300441068									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6824	chr2	175201184	175201204	174336456	174336476	82366	hg19					enhancer	enh				GACTGGCCACCCGCCTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.050224909									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6825	chr2	175201185	175201205	174336457	174336477	82367	hg19					enhancer	enh				GACTGGCCACCCGCCTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014922732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6826	chr2	175201199	175201219	174336471	174336491	82368	hg19					enhancer	enh				GCCAGTCGGCCTTCATTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016383817									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6827	chr2	175201202	175201222	174336474	174336494	82369	hg19					enhancer	enh				GCCTTGGAAATGAAGGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.43052124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6828	chr2	175201210	175201230	174336482	174336502	82370	hg19					enhancer	enh				GCGTGTGCACCTTGGAAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.867318967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6829	chr2	175201211	175201231	174336483	174336503	82371	hg19					enhancer	enh				GCATTTCCAAGGTGCACACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.432997475									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6830	chr2	175201219	175201239	174336491	174336511	82372	hg19					enhancer	enh				GGCTGCCGTCGTGTGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.44297906									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6831	chr2	175201221	175201241	174336493	174336513	82373	hg19					enhancer	enh				GTGCACACGACGGCAGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.230340683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6832	chr2	175201222	175201242	174336494	174336514	82374	hg19					enhancer	enh				GTGCACACGACGGCAGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.428017595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6833	chr2	175201238	175201258	174336510	174336530	82375	hg19					enhancer	enh				GCGACGGGCTGTACCCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.108783518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6834	chr2	175201239	175201259	174336511	174336531	82376	hg19					enhancer	enh				GACGGGCTGTACCCGCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.050333007									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6835	chr2	175201240	175201260	174336512	174336532	82377	hg19					enhancer	enh				GCACGCGCGGGTACAGCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.077570438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6836	chr2	175201244	175201264	174336516	174336536	82378	hg19					enhancer	enh				GCTGTACCCGCGCGTGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040441805									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6837	chr2	175201253	175201273	174336525	174336545	82379	hg19					enhancer	enh				GGTGCGCCATGCCCACGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.003995898									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6838	chr2	175201254	175201274	174336526	174336546	82380	hg19					enhancer	enh				GGGTGCGCCATGCCCACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.119267535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6839	chr2	175201264	175201284	174336536	174336556	82381	hg19					enhancer	enh				GTGGCGCACCCGTACGAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.175590287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6840	chr2	175201274	175201294	174336546	174336566	82382	hg19					enhancer	enh				GTACGAGTCCTGGTACAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.546357968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6841	chr2	175201274	175201294	174336546	174336566	82383	hg19					enhancer	enh				GACTTGTACCAGGACTCGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-3.349017928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6842	chr2	175201275	175201295	174336547	174336567	82384	hg19					enhancer	enh				GTACGAGTCCTGGTACAAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.405448954									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6843	chr2	175201275	175201295	174336547	174336567	82385	hg19					enhancer	enh				GACTTGTACCAGGACTCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.511389477									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6844	chr2	175201285	175201305	174336557	174336577	82386	hg19					enhancer	enh				GATGGAAGCCCGACTTGTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.697447668									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6845	chr2	175201292	175201312	174336564	174336584	82387	hg19					enhancer	enh				GTCGGGCTTCCATTCGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.050581033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6846	chr2	175201295	175201315	174336567	174336587	82388	hg19					enhancer	enh				GGGCTTCCATTCGACGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.644081856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6847	chr2	175201299	175201319	174336571	174336591	82389	hg19					enhancer	enh				GTTCCATTCGACGCTGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.221513563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6848	chr2	175201304	175201324	174336576	174336596	82390	hg19					enhancer	enh				GTTCGACGCTGGCGGCCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.095832167									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6849	chr2	175201304	175201324	174336576	174336596	82391	hg19					enhancer	enh				GCGCCGGCCGCCAGCGTCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.01242056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6850	chr2	175201314	175201334	174336586	174336606	82392	hg19					enhancer	enh				GCGGCCGGCGAGGTGACCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.055172522									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6851	chr2	175201319	175201339	174336591	174336611	82393	hg19					enhancer	enh				GCGGCGAGGTGACCAACGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.200112238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6852	chr2	175201321	175201341	174336593	174336613	82394	hg19					enhancer	enh				GCGCGCCGTTGGTCACCTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223423279									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6853	chr2	175201330	175201350	174336602	174336622	82395	hg19					enhancer	enh				GCCAACGGCGCGGCGTCGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014861193									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6854	chr2	175201333	175201353	174336605	174336625	82396	hg19					enhancer	enh				GCCACGACGACGCCGCGCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.016051768									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6855	chr2	175201352	175201372	174336624	174336644	82397	hg19					enhancer	enh				GTGGGACGTGCACAGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.678614642									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6856	chr2	175201353	175201373	174336625	174336645	82398	hg19					enhancer	enh				GTGGGACGTGCACAGCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.38300341									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6857	chr2	175201360	175201380	174336632	174336652	82399	hg19					enhancer	enh				GTGCACAGCAGCCCGGGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.086729451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6858	chr2	175201364	175201384	174336636	174336656	82400	hg19					enhancer	enh				GCAGCAGCCCGGGCTCGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.346684286									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6859	chr2	175201373	175201393	174336645	174336665	82401	hg19					enhancer	enh				GCACTTCCAGCCACGAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.199861875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6860	chr2	175201374	175201394	174336646	174336666	82402	hg19					enhancer	enh				GTGCACTTCCAGCCACGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.9731523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6861	chr2	175201383	175201403	174336655	174336675	82403	hg19					enhancer	enh				GCTGGAAGTGCAGAACCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.967865049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6862	chr2	175201384	175201404	174336656	174336676	82404	hg19					enhancer	enh				GTGGAAGTGCAGAACCCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.658489974									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6863	chr2	175201385	175201405	174336657	174336677	82405	hg19					enhancer	enh				GGAAGTGCAGAACCCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.002198156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6864	chr2	175201386	175201406	174336658	174336678	82406	hg19					enhancer	enh				GAAGTGCAGAACCCCGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.108298878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6865	chr2	175201387	175201407	174336659	174336679	82407	hg19					enhancer	enh				GAAGTGCAGAACCCCGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.022287743									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6866	chr2	175201400	175201420	174336672	174336692	82408	hg19					enhancer	enh				GAGCTCTGGAGCCCCCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.240926941									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6867	chr2	175201401	175201421	174336673	174336693	82409	hg19					enhancer	enh				GAGCTCTGGAGCCCCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.661523459									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6868	chr2	175201402	175201422	174336674	174336694	82410	hg19					enhancer	enh				GCGAGCTCTGGAGCCCCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.085471345									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6869	chr2	175201409	175201429	174336681	174336701	82411	hg19					enhancer	enh				GCTCCAGAGCTCGCTGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.15466348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6870	chr2	175201410	175201430	174336682	174336702	82412	hg19					enhancer	enh				GCTCCAGAGCTCGCTGCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.040378654									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6871	chr2	175201415	175201435	174336687	174336707	82413	hg19					enhancer	enh				GCGCCCGAGTGCAGCGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.057554748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6872	chr2	175201421	175201441	174336693	174336713	82414	hg19					enhancer	enh				GCTGCACTCGGGCGCCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.021533381									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6873	chr2	175201439	175201459	174336711	174336731	82415	hg19					enhancer	enh				GCGAGTGCAGCGAGGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.073273295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6874	chr2	175201440	175201460	174336712	174336732	82416	hg19					enhancer	enh				GTGCGAGTGCAGCGAGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.070107617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6875	chr2	175201441	175201461	174336713	174336733	82417	hg19					enhancer	enh				GCTGCGAGTGCAGCGAGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.246804219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6876	chr2	175201442	175201462	174336714	174336734	82418	hg19					enhancer	enh				GCTGCGAGTGCAGCGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.134417975									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6877	chr2	175201442	175201462	174336714	174336734	82419	hg19					enhancer	enh				GGCCTCGCTGCACTCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.082174695									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6878	chr2	175201443	175201463	174336715	174336735	82420	hg19					enhancer	enh				GCCTCGCTGCACTCGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191043183									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6879	chr2	175201447	175201467	174336719	174336739	82421	hg19					enhancer	enh				GCCCAGCTGCGAGTGCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.183243274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6880	chr2	175201471	175201491	174336743	174336763	82422	hg19					enhancer	enh				GCGAGCTGAAGTCGGGGTTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130593256									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6881	chr2	175201478	175201498	174336750	174336770	82423	hg19					enhancer	enh				GCGTGAGCGAGCTGAAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.036026692									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6882	chr2	175201480	175201500	174336752	174336772	82424	hg19					enhancer	enh				GTGCGTGAGCGAGCTGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.048809769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6883	chr2	175201496	175201516	174336768	174336788	82425	hg19					enhancer	enh				GCACTCCGCCTTCAGCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.287692042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6884	chr2	175201497	175201517	174336769	174336789	82426	hg19					enhancer	enh				GCACTCCGCCTTCAGCTCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.161264348									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6885	chr2	175201503	175201523	174336775	174336795	82427	hg19					enhancer	enh				GCCTTCAGCTCCACGGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.114520317									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6886	chr2	175201504	175201524	174336776	174336796	82428	hg19					enhancer	enh				GAGGCCCGTGGAGCTGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.046380481									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6887	chr2	175201507	175201527	174336779	174336799	82429	hg19					enhancer	enh				GCCGAGGCCCGTGGAGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.950284906									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6888	chr2	175201556	175201576	174336828	174336848	82430	hg19					enhancer	enh				GCTCCACCAGCCAGCACCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.228980853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6889	chr2	175201568	175201588	174336840	174336860	82431	hg19					enhancer	enh				GCGTCCTGGGCCAGCAGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.435203832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6890	chr2	175201574	175201594	174336846	174336866	82432	hg19					enhancer	enh				GTGAAGCCGTCCTGGGCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.398427758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6891	chr2	175201577	175201597	174336849	174336869	82433	hg19					enhancer	enh				GGCCCAGGACGGCTTCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.116470051									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6892	chr2	175201582	175201602	174336854	174336874	82434	hg19					enhancer	enh				GCACCGGCTTGAAGCCGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.42375026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6893	chr2	175201583	175201603	174336855	174336875	82435	hg19					enhancer	enh				GACACCGGCTTGAAGCCGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.299961183									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6894	chr2	175201595	175201615	174336867	174336887	82436	hg19					enhancer	enh				GCCGGTGTTGCCCTCCTATT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.13927326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6895	chr2	175201599	175201619	174336871	174336891	82437	hg19					enhancer	enh				GTCCGAATAGGAGGGCAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.054030414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6896	chr2	175201608	175201628	174336880	174336900	82438	hg19					enhancer	enh				GCGCTGGAGTCCGAATAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.633346742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6897	chr2	175201609	175201629	174336881	174336901	82439	hg19					enhancer	enh				GGCGCTGGAGTCCGAATAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.345401211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6898	chr2	175201612	175201632	174336884	174336904	82440	hg19					enhancer	enh				GGCGGCGCTGGAGTCCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177774869									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6899	chr2	175201613	175201633	174336885	174336905	82441	hg19					enhancer	enh				GTTCGGACTCCAGCGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.297664938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6900	chr2	175201633	175201653	174336905	174336925	82442	hg19					enhancer	enh				GCTGGCGGCGGCGGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.01058755									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6901	chr2	175201642	175201662	174336914	174336934	82443	hg19					enhancer	enh				GTATCATGGCGCTGGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.158543829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6902	chr2	175201643	175201663	174336915	174336935	82444	hg19					enhancer	enh				GCGCCGCCAGCGCCATGATAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.155727524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6903	chr2	175201644	175201664	174336916	174336936	82445	hg19					enhancer	enh				GCCGCCAGCGCCATGATATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.469130616									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6904	chr2	175201645	175201665	174336917	174336937	82446	hg19					enhancer	enh				GCGATATCATGGCGCTGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.264016441									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6905	chr2	175201648	175201668	174336920	174336940	82447	hg19					enhancer	enh				GCCCGATATCATGGCGCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.195177512									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6906	chr2	175201651	175201671	174336923	174336943	82448	hg19					enhancer	enh				GGCGCCCGATATCATGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.331515486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6907	chr2	175201652	175201672	174336924	174336944	82449	hg19					enhancer	enh				GCGCCATGATATCGGGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040489118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6908	chr2	175201657	175201677	174336929	174336949	82450	hg19					enhancer	enh				GAGCCGCGGCGCCCGATATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.136519322									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6909	chr2	175201681	175201701	174336953	174336973	82451	hg19					enhancer	enh				GTGCCGAGCTCCCCCCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.230543293									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6910	chr2	175201684	175201704	174336956	174336976	82452	hg19					enhancer	enh				GCGTGCCGAGCTCCCCCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.011784868									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6911	chr2	175201687	175201707	174336959	174336979	82453	hg19					enhancer	enh				GAGAGCGTGCCGAGCTCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.462439715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6912	chr2	175201700	175201720	174336972	174336992	82454	hg19					enhancer	enh				GACGCTCTGCCCGCCGCTACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.890281675									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6913	chr2	175201701	175201721	174336973	174336993	82455	hg19					enhancer	enh				GCGCTCTGCCCGCCGCTACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.275161109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6914	chr2	175201711	175201731	174336983	174337003	82456	hg19					enhancer	enh				GGCGCGGCCCGAGTAGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.668473546									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6915	chr2	175201739	175201759	174337011	174337031	82457	hg19					enhancer	enh				GCTGCCCCAACTGCCAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.983150109									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6916	chr2	175201744	175201764	174337016	174337036	82458	hg19					enhancer	enh				GCCAACTGCCAGGAGGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-2.568999871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6917	chr2	175201745	175201765	174337017	174337037	82459	hg19					enhancer	enh				GCTCCGCCTCCTGGCAGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.062493719									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6918	chr2	175201746	175201766	174337018	174337038	82460	hg19					enhancer	enh				GCGCTCCGCCTCCTGGCAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.084753852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6919	chr2	175201747	175201767	174337019	174337039	82461	hg19					enhancer	enh				GCCGCTCCGCCTCCTGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.301048905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6920	chr2	175201754	175201774	174337026	174337046	82462	hg19					enhancer	enh				GGCCCAGCCGCTCCGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.342143202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6921	chr2	175201771	175201791	174337043	174337063	82463	hg19					enhancer	enh				GCCCGGCCGGGGCGAGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.100841822									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6922	chr2	175201775	175201795	174337047	174337067	82464	hg19					enhancer	enh				GCCGCAGGCTCGCCCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.254674528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6923	chr2	175201776	175201796	174337048	174337068	82465	hg19					enhancer	enh				GCGCCGCAGGCTCGCCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.156306751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6924	chr2	175201779	175201799	174337051	174337071	82466	hg19					enhancer	enh				GGGGCGAGCCTGCGGCGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.235400972									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6925	chr2	175201780	175201800	174337052	174337072	82467	hg19					enhancer	enh				GCTTGCGCCGCAGGCTCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.424487041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6926	chr2	175201790	175201810	174337062	174337082	82468	hg19					enhancer	enh				GTGTGCAGGCCCTTGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.23752034									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6927	chr2	175201802	175201822	174337074	174337094	82469	hg19					enhancer	enh				GCCTGCACAGCTGCCACATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.39329319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6928	chr2	175201803	175201823	174337075	174337095	82470	hg19					enhancer	enh				GCTGCACAGCTGCCACATTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.0441304									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6929	chr2	175201805	175201825	174337077	174337097	82471	hg19					enhancer	enh				GCCGGAATGTGGCAGCTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.546830646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6930	chr2	175201809	175201829	174337081	174337101	82472	hg19					enhancer	enh				GAGCTGCCACATTCCGGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.182442813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6931	chr2	175201814	175201834	174337086	174337106	82473	hg19					enhancer	enh				GCCACATTCCGGGCTGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.159635306									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6932	chr2	175201817	175201837	174337089	174337109	82474	hg19					enhancer	enh				GCCTTGCCGCAGCCCGGAATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.433775834									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6933	chr2	175201942	175201962	174337214	174337234	82475	hg19					enhancer	enh				GACGAGCTGCAGCGGCATCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.09257357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6934	chr2	175201952	175201972	174337224	174337244	82476	hg19					enhancer	enh				GCGGCATCTGCGGACTCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.284995773									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6935	chr2	175201953	175201973	174337225	174337245	82477	hg19					enhancer	enh				GCGGCATCTGCGGACTCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.256408124									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6936	chr2	175201976	175201996	174337248	174337268	82478	hg19					enhancer	enh				GCGAGAAGCGCTTCGCCTGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.783873157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6937	chr2	175201993	175202013	174337265	174337285	82479	hg19					enhancer	enh				GCGCTTGTTGCACACCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.110634807									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6938	chr2	175201998	175202018	174337270	174337290	82480	hg19					enhancer	enh				GATGAAGCGCTTGTTGCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.253753446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6939	chr2	175202037	175202057	174337309	174337329	82481	hg19					enhancer	enh				GAAACACATTAAGACGCACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253978443									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6940	chr2	175202038	175202058	174337310	174337330	82482	hg19					enhancer	enh				GAACACATTAAGACGCACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.006510297									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6941	chr2	175202039	175202059	174337311	174337331	82483	hg19					enhancer	enh				GACACATTAAGACGCACAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.580386177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6942	chr2	175202040	175202060	174337312	174337332	82484	hg19					enhancer	enh				GCACATTAAGACGCACAACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.51794753									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6943	chr2	175202043	175202063	174337315	174337335	82485	hg19					enhancer	enh				GATTAAGACGCACAACGGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.187204387									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6944	chr2	175202046	175202066	174337318	174337338	82486	hg19					enhancer	enh				GAAGACGCACAACGGGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.304759214									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6945	chr2	175202047	175202067	174337319	174337339	82487	hg19					enhancer	enh				GAGACGCACAACGGGGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.318602939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6946	chr2	175202048	175202068	174337320	174337340	82488	hg19					enhancer	enh				GACGCACAACGGGGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.006573439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6947	chr2	175202075	175202095	174337347	174337367	82489	hg19					enhancer	enh				GAAAGGGCAGCGACAGTGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233802162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6948	chr2	175202089	175202110	174337361	174337382	82490	hg19					enhancer	enh				GTGACACGGACGCCAGCAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.452011789									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6949	chr2	175202090	175202110	174337362	174337382	82491	hg19					enhancer	enh				GTGACACGGACGCCAGCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.425610803									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6950	chr2	175202104	175202124	174337376	174337396	82492	hg19					enhancer	enh				GACGGGGCGTCTCCAGGTTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.063614401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6951	chr2	175202111	175202131	174337383	174337403	82493	hg19					enhancer	enh				GATTCGGAACGGGGCGTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.020028595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6952	chr2	175202111	175202132	174337383	174337404	82494	hg19					enhancer	enh				GATTCGGAACGGGGCGTCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.311567366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6953	chr2	175202122	175202142	174337394	174337414	82495	hg19					enhancer	enh				GAGGTCGGGGGATTCGGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.985524969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6954	chr2	175202134	175202154	174337406	174337426	82496	hg19					enhancer	enh				GTCATGCAGGATGAGGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.312921648									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6955	chr2	175202135	175202155	174337407	174337427	82497	hg19					enhancer	enh				GAGTCATGCAGGATGAGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.191123176									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6956	chr2	175202136	175202156	174337408	174337428	82498	hg19					enhancer	enh				GACCTCATCCTGCATGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.140087937									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6957	chr2	175202136	175202156	174337408	174337428	82499	hg19					enhancer	enh				GAGTCATGCAGGATGAGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.0084979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6958	chr2	175202137	175202157	174337409	174337429	82500	hg19					enhancer	enh				GGAGTCATGCAGGATGAGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.48410711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6959	chr2	175202141	175202161	174337413	174337433	82501	hg19					enhancer	enh				GCGCCGGAGTCATGCAGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.54902816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6960	chr2	175202141	175202163	174337413	174337435	82502	hg19					enhancer	enh				GACGCCGGAGTCATGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	direct	Highly Significant	NA				0.275044391									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6961	chr2	175202147	175202167	174337419	174337439	82503	hg19					enhancer	enh				GCACTGACGCCGGAGTCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.392509462									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6962	chr2	175202147	175202169	174337419	174337441	82504	hg19					enhancer	enh				GGCACTGACGCCGGAGTCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	direct	Highly Significant	NA				0.67185875									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6963	chr2	175202147	175202168	174337419	174337440	82505	hg19					enhancer	enh				GCACTGACGCCGGAGTCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.579651809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6964	chr2	175202151	175202172	174337423	174337444	82506	hg19					enhancer	enh				GACTCCGGCGTCAGTGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.012635772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6965	chr2	175202152	175202172	174337424	174337444	82507	hg19					enhancer	enh				GACTCCGGCGTCAGTGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.130799991									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6966	chr2	175202153	175202173	174337425	174337445	82508	hg19					enhancer	enh				GCTCCGGCGTCAGTGCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.401167501									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6967	chr2	175202156	175202176	174337428	174337448	82509	hg19					enhancer	enh				GCGGCGTCAGTGCCGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.159417624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6968	chr2	175202158	175202178	174337430	174337450	82510	hg19					enhancer	enh				GCGCCCGGGCGGCACTGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.225701774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6969	chr2	175202158	175202180	174337430	174337452	82511	hg19					enhancer	enh				GCCGCCCGGGCGGCACTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	direct	Highly Significant	NA				0.236844553									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6970	chr2	175202158	175202179	174337430	174337451	82512	hg19					enhancer	enh				GCGTCAGTGCCGCCCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.00781383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6971	chr2	175202159	175202179	174337431	174337451	82513	hg19					enhancer	enh				GCGTCAGTGCCGCCCGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.549047082									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6972	chr2	175202170	175202190	174337442	174337462	82514	hg19					enhancer	enh				GCGCCGCTGCCGCCGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.086391628									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6973	chr2	175202208	175202228	174337480	174337500	82515	hg19					enhancer	enh				GCGGCGGCGGCGGCCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.522297155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6974	chr2	175202216	175202236	174337488	174337508	82516	hg19					enhancer	enh				GGCGGCCTCCGCGGGAGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.286274128									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6975	chr2	175202224	175202244	174337496	174337516	82517	hg19					enhancer	enh				GTGCTTCCTTGCCTCCCGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.21432202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6976	chr2	175202224	175202246	174337496	174337518	82518	hg19					enhancer	enh				GCTGCTTCCTTGCCTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.183412363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6977	chr2	175202227	175202247	174337499	174337519	82519	hg19					enhancer	enh				GCGCTGCTTCCTTGCCTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.162253254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6978	chr2	175202228	175202249	174337500	174337521	82520	hg19					enhancer	enh				GGGAGGCAAGGAAGCAGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				0.015875257									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6979	chr2	175202229	175202249	174337501	174337521	82521	hg19					enhancer	enh				GGAGGCAAGGAAGCAGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.072510238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6980	chr2	175202248	175202268	174337520	174337540	82522	hg19					enhancer	enh				GCTGGCCCCAACGACTCTTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.152182361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97136	chr2	175202251	175202272	174337523	174337544	82523	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCCAACGACTCTTAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.082566859	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202252	175202272	174337524	174337544	82524	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCCAACGACTCTTAGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.223386308	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202253	175202273	174337525	174337545	82525	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCAACGACTCTTAGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.292760077	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202255	175202275	174337527	174337547	82526	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCGGCCTCTAAGAGTCGTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.14146659	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202256	175202276	174337528	174337548	82527	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCGGCCTCTAAGAGTCGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.33525722	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202257	175202277	174337529	174337549	82528	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCGGCCTCTAAGAGTCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.142894675	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202259	175202280	174337531	174337552	82529	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACTCTTAGAGGCCGGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.94471799	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202260	175202280	174337532	174337552	82530	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACTCTTAGAGGCCGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.408319128	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202274	175202294	174337546	174337566	82531	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGTGCTCGCGCCTCTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.177691658	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202303	175202324	174337575	174337596	82532	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGACACCGAGAACGAACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	direct	Highly Significant	NA				0.204580712	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202304	175202324	174337576	174337596	82533	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGACACCGAGAACGAACGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.082810146	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202309	175202329	174337581	174337601	82534	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCGAGAACGAACGAGAGGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.633559569	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202311	175202332	174337583	174337604	82535	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGAACGAACGAGAGGTTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP9	indirect	Non Significant	NA				-0.734994036	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202312	175202332	174337584	174337604	82536	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGAACGAACGAGAGGTTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.275840825	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202312	175202332	174337584	174337604	82537	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCGAACCTCTCGTTCGTTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.103163652	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202313	175202333	174337585	174337605	82538	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAACGAACGAGAGGTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.50014486	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202361	175202381	174337633	174337653	82539	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GGGGCTTCAGTGACGCCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.104773786	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202362	175202382	174337634	174337654	82540	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GGGCTTCAGTGACGCCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.207913262	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202367	175202387	174337639	174337659	82541	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCAGTGACGCCCCCAGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.416345884	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202368	175202388	174337640	174337660	82542	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCAGTGACGCCCCCAGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.103516909	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202372	175202392	174337644	174337664	82543	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACGCCCCCAGGGCCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.763929577	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202373	175202393	174337645	174337665	82544	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACGCCCCCAGGGCCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.210948034	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202379	175202399	174337651	174337671	82545	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCCCAGCCCGGGCCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.32768475	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202380	175202400	174337652	174337672	82546	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCGCCCAGCCCGGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.371430514	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202381	175202401	174337653	174337673	82547	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCGCGCCCAGCCCGGGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.232682906	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202388	175202408	174337660	174337680	82548	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTCCACCTCGCGCCCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.373804042	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202389	175202409	174337661	174337681	82549	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTCCACCTCGCGCCCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.237032403	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202394	175202414	174337666	174337686	82550	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GGCGCGAGGTGGAGCCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.553104979	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202395	175202415	174337667	174337687	82551	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCGAGGTGGAGCCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.404578622	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202402	175202422	174337674	174337694	82552	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGGAGCCGCTCAGGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.779354197	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202403	175202423	174337675	174337695	82553	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGGAGCCGCTCAGGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.236397321	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202409	175202429	174337681	174337701	82554	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCTCAGGGCTCCCGGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.101216066	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202411	175202431	174337683	174337703	82555	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCAGCCCGGGAGCCCTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.888976105	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202423	175202443	174337695	174337715	82556	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCAGCGGGCGAACCGCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.29718894	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202424	175202444	174337696	174337716	82557	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACAGCGGGCGAACCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.18873029	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202427	175202447	174337699	174337719	82558	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGCGGTTCGCCCGCTGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.423800414	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202439	175202459	174337711	174337731	82559	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGGGGAGCTCCTCGCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.051406346	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202440	175202460	174337712	174337732	82560	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGGGGAGCTCCTCGCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.148832138	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202453	175202473	174337725	174337745	82561	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCCCCTCTGCCTTCCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.253881433	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202458	175202478	174337730	174337750	82562	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GATCCGGGCGCGGAAGGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.967529595	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202459	175202479	174337731	174337751	82563	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTATCCGGGCGCGGAAGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.698695765	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202465	175202485	174337737	174337757	82564	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GATTCTTATCCGGGCGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.178027839	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202469	175202489	174337741	174337761	82565	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTTCGATTCTTATCCGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.115424825	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202472	175202492	174337744	174337764	82566	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCGGATAAGAATCGAACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.14627205	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202474	175202494	174337746	174337766	82567	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCACGCGTTCGATTCTTATCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.591343364	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202475	175202495	174337747	174337767	82568	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCACGCGTTCGATTCTTATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.138525359	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202477	175202497	174337749	174337769	82569	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTAAGAATCGAACGCGTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.329080877	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202516	175202536	174337788	174337808	82570	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAAAGTGTTTGTGTCGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.085079639	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202547	175202567	174337819	174337839	82571	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCCCAGACGTACACATACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.323683217	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202552	175202572	174337824	174337844	82572	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTCCGGTGTATGTGTACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.749013897	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202583	175202603	174337855	174337875	82573	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGCGCGAGTGTGCGTGCTTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.336158518	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202618	175202638	174337890	174337910	82574	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTCGAGAAGTTTGGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.001587835	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202625	175202645	174337897	174337917	82575	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTCTTCGCTCGAGAAGTTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.047550937	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202626	175202646	174337898	174337918	82576	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGCTCTTCGCTCGAGAAGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.086734225	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202636	175202656	174337908	174337928	82577	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGAAGAGCAATACATAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.145635071	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202687	175202707	174337959	174337979	82578	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GGAAAGAGACGGGTGTTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.105713363	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202691	175202711	174337963	174337983	82579	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAAAAGGAAAGAGACGGGTGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.964426927	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202717	175202737	174337989	174338009	82580	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAACAAGCCACCACCCAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.569416659	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202726	175202746	174337998	174338018	82581	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACAGTCCTTTGCTGGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.206137441	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202729	175202749	174338001	174338021	82582	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCTGACAGTCCTTTGCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.263460592	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202745	175202765	174338017	174338037	82583	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCAGAACATTTGAAAACAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.173714277	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202770	175202790	174338042	174338062	82584	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCGATAAAAACACCCTTTGTT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.381824959	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202785	175202805	174338057	174338077	82585	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GATATAATATAATCCAAACAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.04528978	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202818	175202838	174338090	174338110	82586	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGTAGATATCAGGCAGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.176939	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202824	175202844	174338096	174338116	82587	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GATTGTAAGTAGATATCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.212608138	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202856	175202876	174338128	174338148	82588	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTAAAAAAGGAAGCATCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.014416704	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202863	175202883	174338135	174338155	82589	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAGGAAGCATCAAAAGGCTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.810645676	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202879	175202899	174338151	174338171	82590	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCTTAAGGTGAGAAATTAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.043932221	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175202928	175202948	174338200	174338220	82591	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTCATAACATCTGTATAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.033433961	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203010	175203030	174338282	174338302	82592	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GTGGGTGAATCCCTGAAATTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				1.19282613	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203011	175203031	174338283	174338303	82593	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GGGTGAATCCCTGAAATTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.370399022	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203022	175203042	174338294	174338314	82594	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAAAAAACTCCCTGAATTTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.272365685	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203023	175203043	174338295	174338315	82595	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAAAAAAACTCCCTGAATTTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.804895751	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203114	175203134	174338386	174338406	82596	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACTCACAAACACGTAAGTTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.151245257	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203250	175203270	174338522	174338542	82597	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GAAGGTTATTGAGGGGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102862617	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203250	175203270	174338522	174338542	82598	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GAAGGTTATTGAGGGGGAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.102862617	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203257	175203277	174338529	174338549	82599	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCACGAAAAGGTTATTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233199501	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203257	175203277	174338529	174338549	82600	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GCCACGAAAAGGTTATTGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.233199501	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203258	175203278	174338530	174338550	82601	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GCCCACGAAAAGGTTATTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.018046789	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203258	175203278	174338530	174338550	82602	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GCCCACGAAAAGGTTATTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.018046789	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203259	175203279	174338531	174338551	82603	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACCCACGAAAAGGTTATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.58493022	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203259	175203279	174338531	174338551	82604	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GACCCACGAAAAGGTTATTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.58493022	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203260	175203280	174338532	174338552	82605	hg19	N/A	N/A	N/A	Enhatls103969	enhancer	enh				GACCCACGAAAAGGTTATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040283748	SP9	chr2	174334953	174338500	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203260	175203280	174338532	174338552	82606	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GACCCACGAAAAGGTTATTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.040283748	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203269	175203289	174338541	174338561	82607	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GAAAAAAATCGACCCACGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.849590812	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203310	175203330	174338582	174338602	82608	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GTTACCTACAACTAACATTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.928633031	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203311	175203331	174338583	174338603	82609	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GATTACCTACAACTAACATTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.677845504	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203359	175203379	174338631	174338651	82610	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GTCAAAAACGTATATGTAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.725781916	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203452	175203472	174338724	174338744	82611	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GTTAATGTGAAGGCTCTCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.245360663	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203492	175203512	174338764	174338784	82612	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GGAGCGCCTAAAAAATGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.223146697	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203499	175203519	174338771	174338791	82613	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GCTAAAAAATGCAAAGGTCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				0.191357731	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203512	175203532	174338784	174338804	82614	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GAGGTCCTTGGCAGCTTTAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.038687983	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203517	175203537	174338789	174338809	82615	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GCTTGGCAGCTTTAATTGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.473748853	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203519	175203539	174338791	174338811	82616	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GCTCCCCAATTAAAGCTGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.063524838	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203532	175203552	174338804	174338824	82617	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GTGGGGAGGTGCCTAAACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-0.184818941	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203533	175203553	174338805	174338825	82618	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GGGGAGGTGCCTAAACCTCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.342793346	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203536	175203556	174338808	174338828	82619	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GAGGTGCCTAAACCTCTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	direct	Highly Significant	NA				0.614873144	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97136	chr2	175203537	175203557	174338809	174338829	82620	hg19	hs953	N/A	N/A	Enhatls103969	enhancer	enh				GAGGTGCCTAAACCTCTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	negative_control	indirect	Non Significant	NA				-1.077744239	SP9	chr2	174334953	174338500	36				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9062
enhrx-97223	chr2	176866878	176866898	176002150	176002170	82621	hg19	N/A	N/A	N/A	Enhatls104058	enhancer	enh				GCGTTCTACCTGCAAGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.525972699	LNPK	chr2	175923881	176002839	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9149
enhrx-lit6981	chr2	176866893	176866914	176002165	176002186	82622	hg19					enhancer	enh				GAAGCGGGCGCAGCCCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				0.066192857									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6982	chr2	176866947	176866967	176002219	176002239	82623	hg19					enhancer	enh				GCCCAGCCTGCCTCCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.240845396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6983	chr2	176866951	176866971	176002223	176002243	82624	hg19					enhancer	enh				GCCTGCTCTGGAGGCAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.003226358									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6984	chr2	176866952	176866974	176002224	176002246	82625	hg19					enhancer	enh				GCTGCCTGCTCTGGAGGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.078226252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6985	chr2	176866960	176866980	176002232	176002252	82626	hg19					enhancer	enh				GCGGCTGCTGCCTGCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				0.117776313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6986	chr2	176866963	176866983	176002235	176002255	82627	hg19					enhancer	enh				GTGGCGGCTGCTGCCTGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.819410299									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6987	chr2	176866979	176867000	176002251	176002272	82628	hg19					enhancer	enh				GGCTTGTCTCTCTGTCAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.069892617									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6988	chr2	176866982	176867004	176002254	176002276	82629	hg19					enhancer	enh				GCCCGGCTTGTCTCTCTGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	direct	Highly Significant	NA				0.380141254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6989	chr2	176867001	176867023	176002273	176002295	82630	hg19					enhancer	enh				GTTTCATGGGAAGGAGTTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-0.231166609									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6990	chr2	176867006	176867026	176002278	176002298	82631	hg19					enhancer	enh				GGGGTTTCATGGGAAGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	indirect	Non Significant	NA				-1.820644244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6991	chr2	176867012	176867032	176002284	176002304	82632	hg19					enhancer	enh				GAGCGCGGGGTTTCATGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	direct	Highly Significant	NA				0.27928615									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6992	chr2	176867026	176867047	176002298	176002319	82633	hg19					enhancer	enh				GCGCTCCAGCCGCTCGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	KIAA1715	direct	Highly Significant	NA				0.245234184									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97484	chr2	179659561	179659581	178794834	178794854	82634	hg19	N/A	N/A	N/A	Enhatls104323	enhancer	enh				GAAACTCAGTCTGTATAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.100152948	TTN	chr2	178525988	178830802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9410
enhrx-97484	chr2	179659576	179659597	178794849	178794870	82635	hg19	N/A	N/A	N/A	Enhatls104323	enhancer	enh				GTTTCATGGCAGAAATCCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.465483741	TTN	chr2	178525988	178830802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9410
enhrx-97484	chr2	179659598	179659620	178794871	178794893	82636	hg19	N/A	N/A	N/A	Enhatls104323	enhancer	enh				GGAGAAACTAGAATGTGAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.740078584	TTN	chr2	178525988	178830802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9410
enhrx-97484	chr2	179659599	179659620	178794872	178794893	82637	hg19	N/A	N/A	N/A	Enhatls104323	enhancer	enh				GAGAAACTAGAATGTGAAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.747985454	TTN	chr2	178525988	178830802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9410
enhrx-97484	chr2	179659636	179659657	178794909	178794930	82638	hg19	N/A	N/A	N/A	Enhatls104323	enhancer	enh				GCTAAAGAGGTACTGTCAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.236664178	TTN	chr2	178525988	178830802	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9410
enhrx-lit6993	chr2	179659640	179659662	178794913	178794935	82639	hg19					enhancer	enh				GACAGTACCTCTTTAGCACCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.013363956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6994	chr2	179659650	179659672	178794923	178794945	82640	hg19					enhancer	enh				GCTGTTGCCACTGGTGCTAAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				0.068363669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6995	chr2	179659661	179659681	178794934	178794954	82641	hg19					enhancer	enh				GCAGCAGAGGCTGTTGCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-1.494660444									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6996	chr2	179659670	179659692	178794943	178794965	82642	hg19					enhancer	enh				GCCTCTGCTGCGTAGCTAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.845667661									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6997	chr2	179659674	179659696	178794947	178794969	82643	hg19					enhancer	enh				GCCAGTGCTAGCTACGCAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.238980445									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6998	chr2	179659684	179659704	178794957	178794977	82644	hg19					enhancer	enh				GCTAGCACTGGCCGACACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.169604945									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit6999	chr2	179659709	179659731	178794982	178795004	82645	hg19					enhancer	enh				GCAGCACCCGCAGCACCACTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.482998339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7000	chr2	179659718	179659738	178794991	178795011	82646	hg19					enhancer	enh				GTGACCATCAGTGGTGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				0.156219578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7001	chr2	179659746	179659766	178795019	178795039	82647	hg19					enhancer	enh				GGAAGGGAGATACGGTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.057836739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7002	chr2	179659767	179659787	178795040	178795060	82648	hg19					enhancer	enh				GATCAGGACAGAAGAGAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.316834827									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7003	chr2	179659783	179659805	178795056	178795078	82649	hg19					enhancer	enh				GCTGACAACCTCTACTCAGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				0.175955428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7004	chr2	179659843	179659864	178795116	178795137	82650	hg19					enhancer	enh				GTAGCCCTCTTGCTTCCAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.042848886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7005	chr2	179659864	179659884	178795137	178795157	82651	hg19					enhancer	enh				GGGAGGCACTTCAGGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	direct	Highly Significant	NA				0.24642746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7006	chr2	179659869	179659890	178795142	178795163	82652	hg19					enhancer	enh				GCACTTCAGGACCTGTGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TTN	indirect	Non Significant	NA				-0.488990333									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7007	chr2	182756472	182756494	181891745	181891767	82653	hg19					enhancer	enh				GCCTGCTCCGGGCGCGTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	direct	Highly Significant	NA				0.895132104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7008	chr2	182756516	182756537	181891789	181891810	82654	hg19					enhancer	enh				GCTGGGAGCCGAGCGCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.359033577									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7009	chr2	182756527	182756547	181891800	181891820	82655	hg19					enhancer	enh				GGCTCCCAGCCGCGCTCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.150096859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7010	chr2	182756539	182756559	181891812	181891832	82656	hg19					enhancer	enh				GCTAGTGGCCCGAGGGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.411627722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7011	chr2	182756546	182756567	181891819	181891840	82657	hg19					enhancer	enh				GCGGGAGCGCTAGTGGCCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.28256243									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7012	chr2	182756547	182756567	181891820	181891840	82658	hg19					enhancer	enh				GCGGGAGCGCTAGTGGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.500646924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7013	chr2	182756575	182756596	181891848	181891869	82659	hg19					enhancer	enh				GGCCGCCTTCATGTGAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				0.115444086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7014	chr2	182756576	182756596	181891849	181891869	82660	hg19					enhancer	enh				GCCGCCTTCATGTGAAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	direct	Highly Significant	NA				0.397054144									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7015	chr2	182756580	182756600	181891853	181891873	82661	hg19					enhancer	enh				GCCGGCGCTTCACATGAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.480806828									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7016	chr2	182756583	182756604	181891856	181891877	82662	hg19					enhancer	enh				GAGGGCCGGCGCTTCACATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.096278602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7017	chr2	182756670	182756690	181891943	181891963	82663	hg19					enhancer	enh				GCGCCCGCTTCAGCTCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				0.069093979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7018	chr2	182756676	182756696	181891949	181891969	82664	hg19					enhancer	enh				GGGCCCCGGGGAGCTGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	indirect	Non Significant	NA				-0.828180138									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7019	chr2	182756699	182756721	181891972	181891994	82665	hg19					enhancer	enh				GCCCGGCCGGGCGCTGACAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	direct	Highly Significant	NA				0.433701619									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7020	chr2	182756704	182756726	181891977	181891999	82666	hg19					enhancer	enh				GCCCTTGCTGTCAGCGCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SSFA2	direct	Highly Significant	NA				0.342951908									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-97764	chr2	187454703	187454723	186589976	186589996	82667	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GAAGGAGGAGGAGCCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.163587748	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454721	187454741	186589994	186590014	82668	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCACTGGGAGGAGACCTGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.072589109	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454725	187454746	186589998	186590019	82669	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GGTCTCCTCCCAGTGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.036335127	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454726	187454746	186589999	186590019	82670	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GTCTCCTCCCAGTGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				0.049887916	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454736	187454758	186590009	186590031	82671	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCCTGAGAGCCGCGGCGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	direct	Highly Significant	NA				0.230565986	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454737	187454758	186590010	186590031	82672	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCCTGAGAGCCGCGGCGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	direct	Highly Significant	NA				0.50992535	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454745	187454766	186590018	186590039	82673	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCGGCTCTCAGGCCTGAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.540873714	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454746	187454767	186590019	186590040	82674	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCACCTCAGGCCTGAGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.734334069	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454756	187454778	186590029	186590051	82675	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCCTGAGGTGCGGCGCTCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	direct	Highly Significant	NA				0.3050586	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454760	187454782	186590033	186590055	82676	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCCGGGGTGAGCGCCGCACCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.005904193	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454778	187454799	186590051	186590072	82677	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GTCTGAGGCTGGGGACTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	direct	Highly Significant	NA				0.507611343	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454780	187454801	186590053	186590074	82678	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCGTCTGAGGCTGGGGACTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				0.083180393	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454783	187454805	186590056	186590078	82679	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GTCCCCAGCCTCAGACGCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.249954374	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454789	187454811	186590062	186590084	82680	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCTCCACGCAGCGTCTGAGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				0.032658797	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454790	187454810	186590063	186590083	82681	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCCTCAGACGCTGCGTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-0.179525833	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454812	187454832	186590085	186590105	82682	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GCGGAGCCGGAGGGAAGCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	indirect	Non Significant	NA				-1.623379986	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-97764	chr2	187454821	187454841	186590094	186590114	82683	hg19	N/A	enh62886	N/A	N/A	enhancer	enh				GACGGTCCTTTGCTTCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ITGAV	direct	Highly Significant	NA				0.237683201	ITGAV	chr2	186590009	186680901	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	9690
enhrx-lit7021	chr2	189156336	189156357	188291609	188291630	82684	hg19					enhancer	enh				GTCCGGGCTGAAGACTGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.258451531									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7022	chr2	189156342	189156362	188291615	188291635	82685	hg19					enhancer	enh				GCTGAAGACTGAGTAAGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.625423117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7023	chr2	189156362	189156382	188291635	188291655	82686	hg19					enhancer	enh				GGGCCCCTCCTTCTGCGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.438329994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7024	chr2	189156373	189156393	188291646	188291666	82687	hg19					enhancer	enh				GAGAGAAACCCATCCGCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.293373425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7025	chr2	189156415	189156435	188291688	188291708	82688	hg19					enhancer	enh				GCGCGTGCACGCGGAACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.495476575									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7026	chr2	189156424	189156444	188291697	188291717	82689	hg19					enhancer	enh				GACTATCTCGCGCGTGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				0.167640223									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7027	chr2	189156446	189156466	188291719	188291739	82690	hg19					enhancer	enh				GTCGTTATCTGTGGGCCCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				0.120671659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7028	chr2	189156484	189156506	188291757	188291779	82691	hg19					enhancer	enh				GAAAGTCAGCGAGCTTGAACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				0.014378402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7029	chr2	189156496	189156518	188291769	188291791	82692	hg19					enhancer	enh				GCTTGAACACAGGCGTCCCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.63046536									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7030	chr2	189156508	189156530	188291781	188291803	82693	hg19					enhancer	enh				GCGTCCCGTGTGGAAATGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.06912117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7031	chr2	189156510	189156530	188291783	188291803	82694	hg19					enhancer	enh				GTCCCGTGTGGAAATGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-1.008254606									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7032	chr2	189156515	189156537	188291788	188291810	82695	hg19					enhancer	enh				GTCTCCTTGGACATTTCCACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				0.152185339									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7033	chr2	189156516	189156537	188291789	188291810	82696	hg19					enhancer	enh				GTCTCCTTGGACATTTCCACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.046051411									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7034	chr2	189156534	189156555	188291807	188291828	82697	hg19					enhancer	enh				GACCGCCAGAAGTGCGCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.21869724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7035	chr2	189156557	189156578	188291830	188291851	82698	hg19					enhancer	enh				GAAGGAAACTCTAGCCGACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.238956093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7036	chr2	189156569	189156589	188291842	188291862	82699	hg19					enhancer	enh				GTTTCCTTCTCACCGAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				-0.043243145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7037	chr2	189156589	189156609	188291862	188291882	82700	hg19					enhancer	enh				GGGAGCCCGGCGTTCCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	indirect	Non Significant	NA				0.140962767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7038	chr2	189156600	189156620	188291873	188291893	82701	hg19					enhancer	enh				GTTCCCGGCCGGGAGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GULP1	direct	Highly Significant	NA				0.247497687									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7039	chr2	190446569	190446589	189581843	189581863	82702	hg19					enhancer	enh				GCTGTGCCAAACCAACCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.240400051									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7040	chr2	190446583	190446603	189581857	189581877	82703	hg19					enhancer	enh				GGCTGGTATGCCCCAGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.55515733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7041	chr2	190446589	190446611	189581863	189581885	82704	hg19					enhancer	enh				GCAAAAGGGGCTGGTATGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.143776448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7042	chr2	190446600	190446622	189581874	189581896	82705	hg19					enhancer	enh				GTAACCTACTGGCAAAAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.222856929									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7043	chr2	190446606	190446627	189581880	189581901	82706	hg19					enhancer	enh				GTAAGGTAACCTACTGGCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.620250394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7044	chr2	190446691	190446712	189581965	189581986	82707	hg19					enhancer	enh				GTCTGGCCTGTGCTCAAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				0.061000066									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7045	chr2	190446696	190446716	189581970	189581990	82708	hg19					enhancer	enh				GTCAGTCTGGCCTGTGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.192325651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7046	chr2	190446696	190446718	189581970	189581992	82709	hg19					enhancer	enh				GTGTCAGTCTGGCCTGTGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-1.102430295									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7047	chr2	190446709	190446729	189581983	189582003	82710	hg19					enhancer	enh				GACTGACACCCAGTAGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.7616856									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7048	chr2	190446775	190446796	189582049	189582070	82711	hg19					enhancer	enh				GAGCCCCAAAGGTCTACGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.511139838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7049	chr2	190446777	190446797	189582051	189582071	82712	hg19					enhancer	enh				GCCCCAAAGGTCTACGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.276438276									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7050	chr2	190446786	190446806	189582060	189582080	82713	hg19					enhancer	enh				GTCTACGGGGTGGGTGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.301749973									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7051	chr2	190446795	190446816	189582069	189582090	82714	hg19					enhancer	enh				GTGGGTGCAGCTGGATTCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.1604809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7052	chr2	190446801	190446823	189582075	189582097	82715	hg19					enhancer	enh				GCAGCTGGATTCGGTTGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				0.028219131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7053	chr2	190446808	190446828	189582082	189582102	82716	hg19					enhancer	enh				GATTCGGTTGGGATGTGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	direct	Highly Significant	NA				0.203839155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7054	chr2	190446824	190446844	189582098	189582118	82717	hg19					enhancer	enh				GGTCTGGTGAGTAGAGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC40A1	indirect	Non Significant	NA				-0.836864889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7055	chr2	190627317	190627337	189762591	189762611	82718	hg19					enhancer	enh				GTCGCCGCCTTACAGCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.131179725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7056	chr2	190627363	190627383	189762637	189762657	82719	hg19					enhancer	enh				GGTGCGCAAAAGCGTCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	direct	Highly Significant	NA				0.547007137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7057	chr2	190627396	190627418	189762670	189762692	82720	hg19					enhancer	enh				GCAATTTCACCCACCTTCCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.17480196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7058	chr2	190627416	190627438	189762690	189762712	82721	hg19					enhancer	enh				GTGCTAGCTACTGCCGCCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.069368574									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7059	chr2	190627416	190627436	189762690	189762710	82722	hg19					enhancer	enh				GCTAGCTACTGCCGCCCAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.12321309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7060	chr2	190627447	190627469	189762721	189762743	82723	hg19					enhancer	enh				GTCGACAGTCTTTAGTAGGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	direct	Highly Significant	NA				0.465719157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7061	chr2	190627452	190627473	189762726	189762747	82724	hg19					enhancer	enh				GGCAGTCGACAGTCTTTAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				0.149501378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7062	chr2	190627452	190627474	189762726	189762748	82725	hg19					enhancer	enh				GGGCAGTCGACAGTCTTTAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.316536825									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7063	chr2	190627452	190627472	189762726	189762746	82726	hg19					enhancer	enh				GCAGTCGACAGTCTTTAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	direct	Highly Significant	NA				0.384198766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7064	chr2	190627463	190627484	189762737	189762758	82727	hg19					enhancer	enh				GTCGACTGCCCTTATCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				0.08252309									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7065	chr2	190627474	190627494	189762748	189762768	82728	hg19					enhancer	enh				GCTTTCTCCTGCAGCGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	direct	Highly Significant	NA				0.244605083									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7066	chr2	190627474	190627495	189762748	189762769	82729	hg19					enhancer	enh				GGCTTTCTCCTGCAGCGATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.537770389									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7067	chr2	190627475	190627495	189762749	189762769	82730	hg19					enhancer	enh				GGCTTTCTCCTGCAGCGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				0.116975083									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7068	chr2	190627479	190627501	189762753	189762775	82731	hg19					enhancer	enh				GCTGCAGGAGAAAGCCCGAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.266284636									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7069	chr2	190627486	190627508	189762760	189762782	82732	hg19					enhancer	enh				GAGAAAGCCCGAACCTGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	direct	Highly Significant	NA				0.221588414									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7070	chr2	190627488	190627508	189762762	189762782	82733	hg19					enhancer	enh				GAAAGCCCGAACCTGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				0.023110597									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7071	chr2	190627502	190627524	189762776	189762798	82734	hg19					enhancer	enh				GATGACATCACTTCCGGGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.070242206									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7072	chr2	190627513	190627535	189762787	189762809	82735	hg19					enhancer	enh				GTGATGTCATCGGAACTGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.051450356									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7073	chr2	190627515	190627535	189762789	189762809	82736	hg19					enhancer	enh				GATGTCATCGGAACTGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				0.194785734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7074	chr2	190627553	190627573	189762827	189762847	82737	hg19					enhancer	enh				GCTGCTGTTCCGCTAGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OSGEPL1	indirect	Non Significant	NA				-0.728964928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7075	chr2	191745394	191745415	190880668	190880689	82738	hg19					enhancer	enh				GCTCTGGGTGCGCGGAGAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-2.684422373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7076	chr2	191745411	191745433	190880685	190880707	82739	hg19					enhancer	enh				GCAGTCAAATTTCTCTCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	direct	Highly Significant	NA				1.098744362									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7077	chr2	191745440	191745460	190880714	190880734	82740	hg19					enhancer	enh				GCCAATCAAAAGAGAGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.398633252									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7078	chr2	191745461	191745481	190880735	190880755	82741	hg19					enhancer	enh				GGATTTGAGCCAATCGCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.717914136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7079	chr2	191745469	191745489	190880743	190880763	82742	hg19					enhancer	enh				GCCAATCGCAGCGGGCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.082156402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7080	chr2	191745494	191745514	190880768	190880788	82743	hg19					enhancer	enh				GGGCCGTCGGCGAGCGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.67355272									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7081	chr2	191745500	191745521	190880774	190880795	82744	hg19					enhancer	enh				GAGACCTTCAGCGCTCGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	direct	Highly Significant	NA				0.274884416									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7082	chr2	191745541	191745562	190880815	190880836	82745	hg19					enhancer	enh				GCCTCAGTGCGGAGCCTTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-1.14772382									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7083	chr2	191745558	191745578	190880832	190880852	82746	hg19					enhancer	enh				GGTTCTCTTCGCTCCGCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-2.097967767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7084	chr2	191745561	191745583	190880835	190880857	82747	hg19					enhancer	enh				GCGGAGCGAAGAGAACCGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.7431814									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7085	chr2	191745563	191745583	190880837	190880857	82748	hg19					enhancer	enh				GGAGCGAAGAGAACCGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.76336567									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7086	chr2	191745579	191745600	190880853	190880874	82749	hg19					enhancer	enh				GCGCGCTAGGATTGCCGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-1.03072934									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7087	chr2	191745637	191745659	190880911	190880933	82750	hg19					enhancer	enh				GCAGCAGCACCCGCATCCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.836860241									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7088	chr2	191745640	191745660	190880914	190880934	82751	hg19					enhancer	enh				GCAGCACCCGCATCCGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-0.672117905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7089	chr2	191745650	191745672	190880924	190880946	82752	hg19					enhancer	enh				GCTCGGACTCCCGCAGCGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-1.122387706									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7090	chr2	191745656	191745678	190880930	190880952	82753	hg19					enhancer	enh				GTTCCGGCTCGGACTCCCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GLS	indirect	Non Significant	NA				-1.162308939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7091	chr2	197036123	197036145	196171399	196171421	82754	hg19					enhancer	enh				GAACTCGTCCTGTGGCGGCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.050957776									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7092	chr2	197036133	197036153	196171409	196171429	82755	hg19					enhancer	enh				GAGCTAGAGAACTCGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.451392114									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7093	chr2	197036165	197036185	196171441	196171461	82756	hg19					enhancer	enh				GCGCCAGGGAGCTCCGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.24938131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7094	chr2	197036222	197036243	196171498	196171519	82757	hg19					enhancer	enh				GAGAAGCCAGGTCACAACCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.243585541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7095	chr2	197036235	197036256	196171511	196171532	82758	hg19					enhancer	enh				GGAGTCACTTCACGAGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.605036686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7096	chr2	197036235	197036255	196171511	196171531	82759	hg19					enhancer	enh				GAGTCACTTCACGAGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.286809047									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7097	chr2	197036236	197036256	196171512	196171532	82760	hg19					enhancer	enh				GCTTCTCGTGAAGTGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.114969089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7098	chr2	197036248	197036268	196171524	196171544	82761	hg19					enhancer	enh				GTGACTCCTGGCGACAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.195928759									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7099	chr2	197036257	197036278	196171533	196171554	82762	hg19					enhancer	enh				GTCCTCTCCGCTGCTGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.414947102									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7100	chr2	197036274	197036296	196171550	196171572	82763	hg19					enhancer	enh				GGACTACCGAAGCTTGCAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.712503225									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7101	chr2	197036275	197036296	196171551	196171572	82764	hg19					enhancer	enh				GACTACCGAAGCTTGCAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.637674833									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7102	chr2	197036298	197036320	196171574	196171596	82765	hg19					enhancer	enh				GTTTGAAAACTGCAGCCGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.162702778									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7103	chr2	197036316	197036336	196171592	196171612	82766	hg19					enhancer	enh				GAACGGCGATGCCCCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.760806797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7104	chr2	197036316	197036338	196171592	196171614	82767	hg19					enhancer	enh				GCGAACGGCGATGCCCCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.310033141									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7105	chr2	197036351	197036371	196171627	196171647	82768	hg19					enhancer	enh				GATTGGCTCTCCCGACCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				-0.424894592									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7106	chr2	197036359	197036381	196171635	196171657	82769	hg19					enhancer	enh				GGAGAGCCAATCGGAACGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.243745245									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7107	chr2	197036364	197036385	196171640	196171661	82770	hg19					enhancer	enh				GCCAATCGGAACGGGTGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.118783029									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7108	chr2	197036387	197036408	196171663	196171684	82771	hg19					enhancer	enh				GTGGGTCTGTCACGTGACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	direct	Highly Significant	NA				0.89786506									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7109	chr2	197036453	197036473	196171729	196171749	82772	hg19					enhancer	enh				GCGCCGCACCCTCTCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK17B	indirect	Non Significant	NA				0.124984734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7110	chr2	197504254	197504274	196639530	196639550	82773	hg19					enhancer	enh				GCCGTGAACCGAATGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.313191545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7111	chr2	197504261	197504281	196639537	196639557	82774	hg19					enhancer	enh				GCGTAGCGCCGTGAACCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.216043467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7112	chr2	197504287	197504308	196639563	196639584	82775	hg19					enhancer	enh				GCCGGCATCCGGCGGCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.460253052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7113	chr2	197504372	197504393	196639648	196639669	82776	hg19					enhancer	enh				GCCACGGGTGCGCCTGCGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.34775573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7114	chr2	197504387	197504407	196639663	196639683	82777	hg19					enhancer	enh				GCGCAGTAGCTCCGGTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.053716036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7115	chr2	197504395	197504415	196639671	196639691	82778	hg19					enhancer	enh				GCTCCCCGGCGCAGTAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				0.057767227									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7116	chr2	197504445	197504467	196639721	196639743	82779	hg19					enhancer	enh				GCAGCAGGCGAGCGGGTTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.162868582									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7117	chr2	197504455	197504477	196639731	196639753	82780	hg19					enhancer	enh				GCTCCGTACTGCAGCAGGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.150615221									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7118	chr2	197504458	197504480	196639734	196639756	82781	hg19					enhancer	enh				GCCTGCTGCAGTACGGAGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.907671985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7119	chr2	197504462	197504483	196639738	196639759	82782	hg19					enhancer	enh				GCTGCAGTACGGAGCCTCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				0.093631421									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-98260	chr2	197504484	197504505	196639760	196639781	82783	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GGACAGATGGACTGTAAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.242260674	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504485	197504505	196639761	196639781	82784	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GACAGATGGACTGTAAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.978545068	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504492	197504513	196639768	196639789	82785	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GGACTGTAAGGTGAGGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.790536326	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504493	197504513	196639769	196639789	82786	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GACTGTAAGGTGAGGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				-0.279890499	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504497	197504519	196639773	196639795	82787	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GTAAGGTGAGGCTGCCGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.434628221	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504519	197504539	196639795	196639815	82788	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GACCACCCCTCACCAGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.424195293	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504547	197504567	196639823	196639843	82789	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GCGAGGCTTCGGCTCAGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	indirect	Non Significant	NA				0.19364919	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-98260	chr2	197504605	197504625	196639881	196639901	82790	hg19	N/A	N/A	N/A	Enhatls105129	enhancer	enh				GAGTGAGACTGGACTCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CCDC150	direct	Highly Significant	NA				0.283880239	CCDC150	chr2	196639714	196732801	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10186
enhrx-lit7120	chr2	198318121	198318142	197453397	197453418	82791	hg19					enhancer	enh				GTCAGCGACGTGCAACCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.289064688									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7121	chr2	198318224	198318246	197453500	197453522	82792	hg19					enhancer	enh				GCCCTGCAGCACCGCCCTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	direct	Highly Significant	NA				0.242665058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7122	chr2	198318244	198318265	197453520	197453541	82793	hg19					enhancer	enh				GCTGGTCCGGGAGGTGACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.181860832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7123	chr2	198318267	198318289	197453543	197453565	82794	hg19					enhancer	enh				GCCATGATAGACTCTCCGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.12927442									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7124	chr2	198318272	198318293	197453548	197453569	82795	hg19					enhancer	enh				GGAGAGTCTATCATGGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	direct	Highly Significant	NA				0.374200367									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7125	chr2	198318273	198318293	197453549	197453569	82796	hg19					enhancer	enh				GAGAGTCTATCATGGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				0.091552545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7126	chr2	198318277	198318298	197453553	197453574	82797	hg19					enhancer	enh				GTCTATCATGGCAGCTCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.246294155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7127	chr2	198318286	198318306	197453562	197453582	82798	hg19					enhancer	enh				GGCAGCTCGGACTGGTCATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				0.185897894									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7128	chr2	198318295	198318317	197453571	197453593	82799	hg19					enhancer	enh				GACTGGTCATACGGCCTTGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.065571253									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7129	chr2	198318323	198318345	197453599	197453621	82800	hg19					enhancer	enh				GTCTCGGGATGCCGTCCGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.047377707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7130	chr2	198318333	198318354	197453609	197453630	82801	hg19					enhancer	enh				GCCGTCCGAAGTCGGCGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	direct	Highly Significant	NA				0.338897016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7131	chr2	198318337	198318358	197453613	197453634	82802	hg19					enhancer	enh				GCCGCTGTCGCCGACTTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.494348697									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7132	chr2	198318340	198318360	197453616	197453636	82803	hg19					enhancer	enh				GAAGTCGGCGACAGCGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				0.099345401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7133	chr2	198318361	198318382	197453637	197453658	82804	hg19					enhancer	enh				GGCGCAGGCGCCCGTGCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.371498152									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7134	chr2	198318362	198318382	197453638	197453658	82805	hg19					enhancer	enh				GCGCAGGCGCCCGTGCGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.420383205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-98365	chr2	198318374	198318394	197453650	197453670	82806	hg19	N/A	N/A	N/A	Enhatls105243	enhancer	enh				GATTACCTGCCATTCCGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.161552518	COQ10B	chr2	197453492	197475310	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10291
enhrx-98365	chr2	198318379	198318401	197453655	197453677	82807	hg19	N/A	N/A	N/A	Enhatls105243	enhancer	enh				GAATGGCAGGTAATCAACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	COQ10B	indirect	Non Significant	NA				-0.854824251	COQ10B	chr2	197453492	197475310	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10291
enhrx-lit7135	chr2	198364380	198364402	197499656	197499678	82808	hg19					enhancer	enh				GTTCCGCACCGCGCCGCACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	direct	Highly Significant	NA				0.241404156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7136	chr2	198364385	198364405	197499661	197499681	82809	hg19					enhancer	enh				GCGGCGCGGTGCGGAACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.139493538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7137	chr2	198364406	198364426	197499682	197499702	82810	hg19					enhancer	enh				GGGTGCGGGCGGCGACAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.089571209									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-98378	chr2	198364486	198364508	197499762	197499784	82811	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GTGCGGGAAGGCCGCGTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.946464401	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364486	198364508	197499762	197499784	82812	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GTGCGGGAAGGCCGCGTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.946464401	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364488	198364508	197499764	197499784	82813	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGGGAAGGCCGCGTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.982818413	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364488	198364508	197499764	197499784	82814	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGGGAAGGCCGCGTACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.982818413	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364490	198364510	197499766	197499786	82815	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GGGAAGGCCGCGTACCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.413404711	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364490	198364510	197499766	197499786	82816	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GGGAAGGCCGCGTACCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.413404711	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364492	198364513	197499768	197499789	82817	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GAAGGCCGCGTACCTGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.270859032	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364492	198364513	197499768	197499789	82818	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GAAGGCCGCGTACCTGCGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.270859032	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364500	198364520	197499776	197499796	82819	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCCGCCGCCCCGCAGGTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.319552421	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364500	198364520	197499776	197499796	82820	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCCGCCGCCCCGCAGGTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.319552421	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364501	198364521	197499777	197499797	82821	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GTACCTGCGGGGCGGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.605342305	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364501	198364521	197499777	197499797	82822	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GTACCTGCGGGGCGGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.605342305	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364507	198364529	197499783	197499805	82823	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCACGCCTTGCCGCCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.403600121	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364507	198364529	197499783	197499805	82824	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCACGCCTTGCCGCCGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.403600121	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364512	198364532	197499788	197499808	82825	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGGCGGCAAGGCGTGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.822073713	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364512	198364532	197499788	197499808	82826	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGGCGGCAAGGCGTGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.822073713	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364529	198364551	197499805	197499827	82827	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTCGGCGAGACAGGTCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.610040634	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364529	198364551	197499805	197499827	82828	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTCGGCGAGACAGGTCGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-1.610040634	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364553	198364573	197499829	197499849	82829	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGAGTGAGGGACAGAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-2.648846636	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364553	198364573	197499829	197499849	82830	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGAGTGAGGGACAGAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-2.648846636	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364623	198364644	197499899	197499920	82831	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCCCCGCGGCACCGCGTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	direct	Highly Significant	NA				0.405055353	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364623	198364644	197499899	197499920	82832	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCCCCGCGGCACCGCGTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	direct	Highly Significant	NA				0.405055353	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364629	198364651	197499905	197499927	82833	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTGCCTGCACACGCGGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				0.002893186	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364629	198364651	197499905	197499927	82834	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTGCCTGCACACGCGGTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				0.002893186	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364719	198364741	197499995	197500017	82835	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTAGCACACCCTGCGCGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.021013679	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364719	198364741	197499995	197500017	82836	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCTAGCACACCCTGCGCGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-0.021013679	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364725	198364745	197500001	197500021	82837	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGCGCTAGCACACCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-2.498654271	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364725	198364745	197500001	197500021	82838	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCGCGCTAGCACACCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPD1	indirect	Non Significant	NA				-2.498654271	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364935	198364956	197500211	197500232	82839	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GACGCTGACGCGAAGACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.450465254	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364935	198364956	197500211	197500232	82840	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GACGCTGACGCGAAGACTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.450465254	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364960	198364982	197500236	197500258	82841	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCAGGGCCCTTGGGGCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				0.147127633	HSPE1	chr2	197500139	197503449	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-98378	chr2	198364960	198364982	197500236	197500258	82842	hg19	N/A	N/A	N/A	Enhatls105256	enhancer	enh				GCAGGGCCCTTGGGGCGAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				0.147127633	HSPD1	chr2	197486583	197516737	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10304
enhrx-lit7138	chr2	198364970	198364990	197500246	197500266	82843	hg19					enhancer	enh				GCGCACCGCGATTCGCCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.402906118									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7139	chr2	198365027	198365047	197500303	197500323	82844	hg19					enhancer	enh				GGGGCTAGCGGCGACCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-1.695352052									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7140	chr2	198365098	198365119	197500374	197500395	82845	hg19					enhancer	enh				GCCGCAAAGAGACTCGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				0.099802378									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7141	chr2	198365130	198365152	197500406	197500428	82846	hg19					enhancer	enh				GCAGAGTACGAGTCTGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	direct	Highly Significant	NA				0.478832174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7142	chr2	198365133	198365153	197500409	197500429	82847	hg19					enhancer	enh				GAGTACGAGTCTGAGGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-4.321306809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7143	chr2	198365141	198365161	197500417	197500437	82848	hg19					enhancer	enh				GTCTGAGGCGGAGGGAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-4.218024509									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7144	chr2	198365153	198365175	197500429	197500451	82849	hg19					enhancer	enh				GGGAGTAATGGTGAGTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	direct	Highly Significant	NA				0.642460535									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7145	chr2	198365154	198365175	197500430	197500451	82850	hg19					enhancer	enh				GGAGTAATGGTGAGTCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.301595338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7146	chr2	198365155	198365175	197500431	197500451	82851	hg19					enhancer	enh				GAGTAATGGTGAGTCCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-1.857997737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7147	chr2	198365163	198365183	197500439	197500459	82852	hg19					enhancer	enh				GTGAGTCCCGCGTGGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-2.610838883									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7148	chr2	198365173	198365195	197500449	197500471	82853	hg19					enhancer	enh				GCCTGCAGGCCTCGGGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.031036841									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7149	chr2	198365181	198365201	197500457	197500477	82854	hg19					enhancer	enh				GCCCGGGCCTGCAGGCCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-1.815795488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7150	chr2	198365197	198365217	197500473	197500493	82855	hg19					enhancer	enh				GGGCCTGTCTGAGGCGTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-2.09433784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7151	chr2	198365203	198365223	197500479	197500499	82856	hg19					enhancer	enh				GATCCCCGTACGCCTCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-1.071115793									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7152	chr2	198365226	198365247	197500502	197500523	82857	hg19					enhancer	enh				GCCCAACAAAAGAGGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	direct	Highly Significant	NA				0.401745889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7153	chr2	198365276	198365297	197500552	197500573	82858	hg19					enhancer	enh				GACCAGCGCCCGATGGCACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.674200864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7154	chr2	198365281	198365303	197500557	197500579	82859	hg19					enhancer	enh				GCTCCAAGGTGCCATCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HSPE1	indirect	Non Significant	NA				-0.164156041									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7155	chr2	198669125	198669146	197804401	197804422	82860	hg19					enhancer	enh				GCTCGAGTACATTAGCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.333398993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7156	chr2	198669178	198669198	197804454	197804474	82861	hg19					enhancer	enh				GTGTGCCCGAGCGCGAAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	direct	Highly Significant	NA				0.725934844									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7157	chr2	198669269	198669289	197804545	197804565	82862	hg19					enhancer	enh				GACAGCCCTTGGGGATTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.004012516									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7158	chr2	198669308	198669328	197804584	197804604	82863	hg19					enhancer	enh				GTCACAACAGAGCTGAGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.299785784									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7159	chr2	198669340	198669360	197804616	197804636	82864	hg19					enhancer	enh				GGTCCCAGGAAGTGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	direct	Highly Significant	NA				0.452691994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7160	chr2	198669343	198669365	197804619	197804641	82865	hg19					enhancer	enh				GCAGCGGTCCCAGGAAGTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.155562771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7161	chr2	198669346	198669367	197804622	197804643	82866	hg19					enhancer	enh				GCGCAGCGGTCCCAGGAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.056330153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7162	chr2	198669355	198669377	197804631	197804653	82867	hg19					enhancer	enh				GGACCGCTGCGCCGCAGTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.678664205									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7163	chr2	198669356	198669377	197804632	197804653	82868	hg19					enhancer	enh				GACCGCTGCGCCGCAGTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.226301012									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7164	chr2	198669360	198669381	197804636	197804657	82869	hg19					enhancer	enh				GCTGCGCCGCAGTCCGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.397717025									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7165	chr2	198669361	198669381	197804637	197804657	82870	hg19					enhancer	enh				GCCCGCGGACTGCGGCGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.098637488									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7166	chr2	198669368	198669388	197804644	197804664	82871	hg19					enhancer	enh				GCAGTCCGCGGGCAGGTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.032396226									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7167	chr2	198669376	198669396	197804652	197804672	82872	hg19					enhancer	enh				GCGCACCCGCCACCTGCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.207279031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7168	chr2	198669390	198669411	197804666	197804687	82873	hg19					enhancer	enh				GTGCGCCCGGCCGCAGTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				0.127438449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7169	chr2	198669403	198669423	197804679	197804699	82874	hg19					enhancer	enh				GGGCCAGAGCCGGGCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.400224048									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7170	chr2	198669412	198669432	197804688	197804708	82875	hg19					enhancer	enh				GCCCGATAGGGGCCAGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.361167287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7171	chr2	198669413	198669435	197804689	197804711	82876	hg19					enhancer	enh				GCTCTGGCCCCTATCGGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				-0.048261968									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7172	chr2	198669423	198669443	197804699	197804719	82877	hg19					enhancer	enh				GGACGCCGGCGGCCCGATAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PLCL1	indirect	Non Significant	NA				0.055569157									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7173	chr2	201753919	201753939	200889196	200889216	82878	hg19					enhancer	enh				GCTCTACTAATAATTGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.027362987									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7174	chr2	201753946	201753967	200889223	200889244	82879	hg19					enhancer	enh				GAAGTGTAAGGCGAAACTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.079853989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7175	chr2	201753946	201753968	200889223	200889245	82880	hg19					enhancer	enh				GAAGTGTAAGGCGAAACTACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.900306893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7176	chr2	201753985	201754006	200889262	200889283	82881	hg19					enhancer	enh				GCTTTACACTCGGCTGCCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	direct	Highly Significant	NA				0.261696329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7177	chr2	201754027	201754048	200889304	200889325	82882	hg19					enhancer	enh				GCTCCCCGTAGCGGGAGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				0.061633738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7178	chr2	201754028	201754048	200889305	200889325	82883	hg19					enhancer	enh				GCTCCCCGTAGCGGGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				0.124794344									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7179	chr2	201754028	201754049	200889305	200889326	82884	hg19					enhancer	enh				GGCTCCCCGTAGCGGGAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.071488932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7180	chr2	201754036	201754056	200889313	200889333	82885	hg19					enhancer	enh				GGCACTTGGCTCCCCGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				0.181150497									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7181	chr2	201754037	201754058	200889314	200889335	82886	hg19					enhancer	enh				GTGGCACTTGGCTCCCCGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.070018229									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7182	chr2	201754044	201754064	200889321	200889341	82887	hg19					enhancer	enh				GAGCCAAGTGCCACAGCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				0.051228139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7183	chr2	201754050	201754070	200889327	200889347	82888	hg19					enhancer	enh				GCTCCGGATGCTGTGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				0.009050153									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7184	chr2	201754057	201754078	200889334	200889355	82889	hg19					enhancer	enh				GCGTCGGCGCTCCGGATGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-0.117246677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7185	chr2	201754074	201754095	200889351	200889372	82890	hg19					enhancer	enh				GCGTCACTTCCGGTCCCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				0.136912139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7186	chr2	201754090	201754112	200889367	200889389	82891	hg19					enhancer	enh				GACGCAGAGAAGTTTCCGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PPIL3	indirect	Non Significant	NA				-0.380856657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7187	chr2	201754101	201754122	200889378	200889399	82892	hg19					enhancer	enh				GTTTCCGGGACTGGTGAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-0.964197071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7188	chr2	201754202	201754224	200889479	200889501	82893	hg19					enhancer	enh				GTGCTGCAGAGGACAGCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-2.375383224									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7189	chr2	201754204	201754224	200889481	200889501	82894	hg19					enhancer	enh				GCTGCAGAGGACAGCAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-1.384494555									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7190	chr2	201754249	201754270	200889526	200889547	82895	hg19					enhancer	enh				GCGCTGTGCTCTGGTGCGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				0.180605464									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7191	chr2	201754253	201754275	200889530	200889552	82896	hg19					enhancer	enh				GCACCAGAGCACAGCGCACTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-0.01701738									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7192	chr2	201754261	201754282	200889538	200889559	82897	hg19					enhancer	enh				GCACAGCGCACTAGTGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-0.529824902									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7193	chr2	201754261	201754281	200889538	200889558	82898	hg19					enhancer	enh				GCACAGCGCACTAGTGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-1.184168576									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7194	chr2	201754283	201754304	200889560	200889581	82899	hg19					enhancer	enh				GGGTCCTGACTCAGACTTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	direct	Highly Significant	NA				0.884471714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7195	chr2	201754284	201754304	200889561	200889581	82900	hg19					enhancer	enh				GGTCCTGACTCAGACTTAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				0.133838335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7196	chr2	201754296	201754317	200889573	200889594	82901	hg19					enhancer	enh				GACTTAACTGGCTGTGTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	direct	Highly Significant	NA				0.239920021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7197	chr2	201754329	201754349	200889606	200889626	82902	hg19					enhancer	enh				GTCCTGGAAAAGGCCTGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NIF3L1	indirect	Non Significant	NA				-0.079651707									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7198	chr2	202047668	202047688	201182945	201182965	82903	hg19					enhancer	enh				GCTTCCTAGAAACGAACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	direct	Highly Significant	NA				0.265595783									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7199	chr2	202047701	202047721	201182978	201182998	82904	hg19					enhancer	enh				GTAGAGCTTGGGGTTTCCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				-1.619348732									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7200	chr2	202047767	202047787	201183044	201183064	82905	hg19					enhancer	enh				GTTATCTTAACCCTGGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				0.151416543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7201	chr2	202047849	202047870	201183126	201183147	82906	hg19					enhancer	enh				GAAAACTGAATCTTCAGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				-0.387944698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7202	chr2	202047850	202047872	201183127	201183149	82907	hg19					enhancer	enh				GTGAAAACTGAATCTTCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	direct	Highly Significant	NA				0.392283565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7203	chr2	202047850	202047870	201183127	201183147	82908	hg19					enhancer	enh				GAAAACTGAATCTTCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				0.003381816									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7204	chr2	202047892	202047912	201183169	201183189	82909	hg19					enhancer	enh				GAAGTCTCTTCCCAAGCAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				0.099430951									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7205	chr2	202047892	202047913	201183169	201183190	82910	hg19					enhancer	enh				GAAGTCTCTTCCCAAGCAAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				-0.518946813									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7206	chr2	202047931	202047953	201183208	201183230	82911	hg19					enhancer	enh				GTAGAATCCTCTGTGTGCTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				0.01693049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7207	chr2	202047989	202048011	201183266	201183288	82912	hg19					enhancer	enh				GAACCGTTTACTTCCAGAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				-0.098221145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7208	chr2	202048008	202048029	201183285	201183306	82913	hg19					enhancer	enh				GATTGGTGGAGCTTGATCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CASP10	indirect	Non Significant	NA				-0.482700171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7209	chr2	202315981	202316002	201451258	201451279	82914	hg19					enhancer	enh				GTACCGGAGGACCTTGGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.69159513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7210	chr2	202316003	202316023	201451280	201451300	82915	hg19					enhancer	enh				GGAGGTCCCTCCGCTTTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.120955958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7211	chr2	202316013	202316034	201451290	201451311	82916	hg19					enhancer	enh				GACAACTTCCCCGGAAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				0.069396667									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7212	chr2	202316036	202316056	201451313	201451333	82917	hg19					enhancer	enh				GGGCAAGTTCGGGTTCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.180179971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7213	chr2	202316057	202316077	201451334	201451354	82918	hg19					enhancer	enh				GGACAGCTTACTCACTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-1.092840842									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7214	chr2	202316091	202316111	201451368	201451388	82919	hg19					enhancer	enh				GAAGCGCGGGCGGACGACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.615432022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7215	chr2	202316101	202316121	201451378	201451398	82920	hg19					enhancer	enh				GCTTCCTGAGGAAGCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				0.098573467									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7216	chr2	202316101	202316122	201451378	201451399	82921	hg19					enhancer	enh				GGCTTCCTGAGGAAGCGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-2.729305818									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7217	chr2	202316113	202316133	201451390	201451410	82922	hg19					enhancer	enh				GCTGCATTAGGGGCTTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.613118305									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7218	chr2	202316169	202316191	201451446	201451468	82923	hg19					enhancer	enh				GCTCCCACTGCCAGCAACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.170341119									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7219	chr2	202316175	202316196	201451452	201451473	82924	hg19					enhancer	enh				GCCCGGGCGGTTGCTGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	direct	Highly Significant	NA				0.305963733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7220	chr2	202316176	202316196	201451453	201451473	82925	hg19					enhancer	enh				GCCCGGGCGGTTGCTGGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.175566088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7221	chr2	202316182	202316202	201451459	201451479	82926	hg19					enhancer	enh				GCAACCGCCCGGGCGTGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	direct	Highly Significant	NA				0.277187125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7222	chr2	202316189	202316211	201451466	201451488	82927	hg19					enhancer	enh				GCCTGTCCCTGCCACGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				0.115376858									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7223	chr2	202316193	202316215	201451470	201451492	82928	hg19					enhancer	enh				GCCCGCCTGTCCCTGCCACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.036375838									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7224	chr2	202316239	202316261	201451516	201451538	82929	hg19					enhancer	enh				GACCTCGGTTCTGCGGCGACAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	direct	Highly Significant	NA				0.531902845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7225	chr2	202316324	202316344	201451601	201451621	82930	hg19					enhancer	enh				GTCTTGCGCTGGGGCCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	TRAK2	indirect	Non Significant	NA				-0.132120729									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-98746	chr2	203130343	203130363	202265620	202265640	82931	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCCGAGAAAGTTTGTATCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-0.176515266	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130361	203130382	202265638	202265659	82932	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCCCGCCCCAGCCCGCTGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-0.364890989	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130369	203130389	202265646	202265666	82933	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GTTCCCGCCACAGCGGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	direct	Highly Significant	NA				0.293370945	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130381	203130402	202265658	202265679	82934	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCGGGAACATTCTGGAAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-0.381303163	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130441	203130463	202265718	202265740	82935	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCTATCCCAGAATCCTCAGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-1.129068048	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130480	203130502	202265757	202265779	82936	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCGTCCTAGTTCCAGTACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-4.261444998	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130482	203130502	202265759	202265779	82937	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GTCCTAGTTCCAGTACAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-4.566852988	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130494	203130516	202265771	202265793	82938	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCCTAAACCCTCCACGCTGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-2.632239188	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130548	203130569	202265825	202265846	82939	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GCATTTGTGCTTTGCCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	direct	Highly Significant	NA				0.269495982	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130554	203130575	202265831	202265852	82940	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GTGCTTTGCCCGCCGCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-0.250646863	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130634	203130654	202265911	202265931	82941	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GGCCGTGCGGCGCCCTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-1.230568095	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130639	203130659	202265916	202265936	82942	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GGCCGGGTCAGGGCGCCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-2.425112051	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-98746	chr2	203130665	203130687	202265942	202265964	82943	hg19	N/A	enh6115	N/A	N/A	enhancer	enh				GACGTTTCAAACAGCACCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NOP58	indirect	Non Significant	NA				-1.48708996	NOP58	chr2	202265762	202303661	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10672
enhrx-lit7226	chr2	203499553	203499573	202634830	202634850	82944	hg19					enhancer	enh				GACGGTCTCCGCGCACACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	direct	Highly Significant	NA				0.469136728									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7227	chr2	203499598	203499618	202634875	202634895	82945	hg19					enhancer	enh				GCTACGAGCAGCTCGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.12511402									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7228	chr2	203499609	203499630	202634886	202634907	82946	hg19					enhancer	enh				GCTCGTAGCCAATGGGAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.124104716									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7229	chr2	203499620	203499641	202634897	202634918	82947	hg19					enhancer	enh				GAGCCGCTCCACTGCTCCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	direct	Highly Significant	NA				0.317533746									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7230	chr2	203499626	203499646	202634903	202634923	82948	hg19					enhancer	enh				GCAGTGGAGCGGCTCGAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-0.011757819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7231	chr2	203499645	203499665	202634922	202634942	82949	hg19					enhancer	enh				GCGGCTGACGCTGCACCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.186895326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7232	chr2	203499654	203499674	202634931	202634951	82950	hg19					enhancer	enh				GCTGCACCAATGGGCGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-0.107060989									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7233	chr2	203499657	203499678	202634934	202634955	82951	hg19					enhancer	enh				GCACCAATGGGCGATCGTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-0.067747982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7234	chr2	203499692	203499713	202634969	202634990	82952	hg19					enhancer	enh				GAGGAGACACTATTGTTGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	direct	Highly Significant	NA				0.3391559									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7235	chr2	203499697	203499718	202634974	202634995	82953	hg19					enhancer	enh				GACACTATTGTTGATGAGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-0.991373315									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7236	chr2	203499750	203499770	202635027	202635047	82954	hg19					enhancer	enh				GGCCGGGGCAGGCAGCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.032335216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7237	chr2	203499781	203499802	202635058	202635079	82955	hg19					enhancer	enh				GAAGCCGGACTCCGGGGTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-0.594406626									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7238	chr2	203499782	203499802	202635059	202635079	82956	hg19					enhancer	enh				GAAGCCGGACTCCGGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				-3.25483971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7239	chr2	203499788	203499808	202635065	202635085	82957	hg19					enhancer	enh				GGTGACGAAGCCGGACTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.137082067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7240	chr2	203499789	203499809	202635066	202635086	82958	hg19					enhancer	enh				GGGTGACGAAGCCGGACTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.050998767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7241	chr2	203499796	203499818	202635073	202635095	82959	hg19					enhancer	enh				GGCTTCGTCACCCCGTCTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	direct	Highly Significant	NA				0.335666565									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7242	chr2	203499797	203499818	202635074	202635095	82960	hg19					enhancer	enh				GCTTCGTCACCCCGTCTTGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	indirect	Non Significant	NA				0.112232396									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7243	chr2	203499828	203499848	202635105	202635125	82961	hg19					enhancer	enh				GGAGGATTCTCGAGGCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FAM117B	direct	Highly Significant	NA				0.598837021									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7244	chr2	204193035	204193056	203328312	203328333	82962	hg19					enhancer	enh				GTGACCGTCCTCGGAGTCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	direct	Highly Significant	NA				0.324870204									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7245	chr2	204193046	204193066	203328323	203328343	82963	hg19					enhancer	enh				GCGCGAGCCGACGGACTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				0.180269087									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7246	chr2	204193084	204193105	203328361	203328382	82964	hg19					enhancer	enh				GCCCCAGCGCGCGACAGGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.43661191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7247	chr2	204193085	204193105	203328362	203328382	82965	hg19					enhancer	enh				GCCCCAGCGCGCGACAGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.446911451									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7248	chr2	204193089	204193111	203328366	203328388	82966	hg19					enhancer	enh				GAAACAGCCCCAGCGCGCGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.423112208									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7249	chr2	204193090	204193111	203328367	203328388	82967	hg19					enhancer	enh				GAAACAGCCCCAGCGCGCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.682766349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7250	chr2	204193119	204193139	203328396	203328416	82968	hg19					enhancer	enh				GACGGCGGCGGTAACTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				0.1269943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7251	chr2	204193119	204193141	203328396	203328418	82969	hg19					enhancer	enh				GCGACGGCGGCGGTAACTCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				0.075212788									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7252	chr2	204193142	204193164	203328419	203328441	82970	hg19					enhancer	enh				GCCGCTCCTCCTCTCCCGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				0.035970507									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7253	chr2	204193151	204193173	203328428	203328450	82971	hg19					enhancer	enh				GGAAACCCAGGACCGGGAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.112624708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7254	chr2	204193151	204193172	203328428	203328449	82972	hg19					enhancer	enh				GAAACCCAGGACCGGGAGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.02022078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7255	chr2	204193160	204193182	203328437	203328459	82973	hg19					enhancer	enh				GTCCTGGGTTTCCTTGGCGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	direct	Highly Significant	NA				0.485344486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7256	chr2	204193160	204193180	203328437	203328457	82974	hg19					enhancer	enh				GCGCCAAGGAAACCCAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.283881383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7257	chr2	204193165	204193187	203328442	203328464	82975	hg19					enhancer	enh				GGCCGCAGCGCCAAGGAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.371508671									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7258	chr2	204193165	204193186	203328442	203328463	82976	hg19					enhancer	enh				GCCGCAGCGCCAAGGAAACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.139025254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7259	chr2	204193174	204193194	203328451	203328471	82977	hg19					enhancer	enh				GAGCGGCGGCCGCAGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ABI2	indirect	Non Significant	NA				-0.090458319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-98958	chr2	206950468	206950489	206085744	206085765	82978	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCGGAGAATGAAAGGGTGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.674071761	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950476	206950496	206085752	206085772	82979	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCCCCGGGCGGAGAATGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.786930694	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950498	206950518	206085774	206085794	82980	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GGGATTCGCCGGCCCACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.052006309	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950498	206950519	206085774	206085795	82981	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GGGGATTCGCCGGCCCACGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.601196353	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950518	206950539	206085794	206085815	82982	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GAGCGCGCTTACGTGAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.14502843	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950519	206950539	206085795	206085815	82983	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GAGCGCGCTTACGTGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				0.090067355	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950524	206950545	206085800	206085821	82984	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GGCGGCGAGCGCGCTTACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.34696882	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950524	206950544	206085800	206085820	82985	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCGGCGAGCGCGCTTACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.356489553	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950559	206950579	206085835	206085855	82986	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GGCCCAGCCCGCCGCCCTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				0.180144663	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950564	206950585	206085840	206085861	82987	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCTCCCGTAGGGCGGCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.422600227	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950572	206950594	206085848	206085870	82988	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCCCTACGGGAGCCCGGGGATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-2.993592128	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-98958	chr2	206950577	206950599	206085853	206085875	82989	hg19	N/A	N/A	N/A	Enhatls105883	enhancer	enh				GCCCACATCCCCGGGCTCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.324475604	INO80D	chr2	205993720	206086303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10884
enhrx-lit7260	chr2	206950688	206950709	206085964	206085985	82990	hg19					enhancer	enh				GAGAGGCGCTGGCAATGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.412792727									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7261	chr2	206950695	206950717	206085971	206085993	82991	hg19					enhancer	enh				GCTGGCAATGGACTAGGAAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.406288042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7262	chr2	206950743	206950765	206086019	206086041	82992	hg19					enhancer	enh				GAAAGGCTCTCGCCGGAGCCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.014489878									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7263	chr2	206950854	206950875	206086130	206086151	82993	hg19					enhancer	enh				GAATATACTCTCCAGCCAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				0.17256607									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7264	chr2	206950868	206950888	206086144	206086164	82994	hg19					enhancer	enh				GGCAGCCCTGCCTTCTTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.333412262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7265	chr2	206950868	206950889	206086144	206086165	82995	hg19					enhancer	enh				GCCAAGAAGGCAGGGCTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.139521166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7266	chr2	206950882	206950904	206086158	206086180	82996	hg19					enhancer	enh				GCTGCCGGGGCTGTACAAGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				0.055008772									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7267	chr2	206950889	206950911	206086165	206086187	82997	hg19					enhancer	enh				GCTGCCTCTTCTTGTACAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				0.028554633									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7268	chr2	206950912	206950932	206086188	206086208	82998	hg19					enhancer	enh				GCCTCCTACAGCACCACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	indirect	Non Significant	NA				-0.610865933									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7269	chr2	206950916	206950936	206086192	206086212	82999	hg19					enhancer	enh				GCCTGTAGTGGTGCTGTAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.295047212									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7270	chr2	206950922	206950942	206086198	206086218	83000	hg19					enhancer	enh				GCACCACTACAGGCACTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INO80D	direct	Highly Significant	NA				0.407015498									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7271	chr2	207630163	207630183	206765439	206765459	83001	hg19					enhancer	enh				GGATACCACAGAGCTTATAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.579881725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7272	chr2	207630185	207630205	206765461	206765481	83002	hg19					enhancer	enh				GAGCCCCACTCCTGTATGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.582161791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7273	chr2	207630285	207630307	206765561	206765583	83003	hg19					enhancer	enh				GAGATCTTACGGATTCCCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.311241305									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7274	chr2	207630285	207630305	206765561	206765581	83004	hg19					enhancer	enh				GATCTTACGGATTCCCTCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.799533863									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7275	chr2	207630307	207630327	206765583	206765603	83005	hg19					enhancer	enh				GTGAGAAGCGCAGCTTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	direct	Highly Significant	NA				0.556224709									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7276	chr2	207630319	207630339	206765595	206765615	83006	hg19					enhancer	enh				GCTTCTCGGGGAAGCTGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	direct	Highly Significant	NA				0.29582139									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7277	chr2	207630340	207630361	206765616	206765637	83007	hg19					enhancer	enh				GGCTGCTCCTGTACGTAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.344728812									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7278	chr2	207630341	207630361	206765617	206765637	83008	hg19					enhancer	enh				GCTGCTCCTGTACGTAGTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.090580302									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7279	chr2	207630350	207630372	206765626	206765648	83009	hg19					enhancer	enh				GCACAAGACCGTGACTACGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.455295258									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7280	chr2	207630362	207630383	206765638	206765659	83010	hg19					enhancer	enh				GGTCTTGTGCTCTAAGGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.892989394									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7281	chr2	207630363	207630383	206765639	206765659	83011	hg19					enhancer	enh				GTCTTGTGCTCTAAGGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.093531014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7282	chr2	207630445	207630466	206765721	206765742	83012	hg19					enhancer	enh				GAAGAGTCTCACGAGTTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.324846881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7283	chr2	207630462	207630484	206765738	206765760	83013	hg19					enhancer	enh				GTCCTGGAAGTAAGTTTAAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-1.551561359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7284	chr2	207630467	207630487	206765743	206765763	83014	hg19					enhancer	enh				GGAAGTAAGTTTAAAGGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-2.02516972									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7285	chr2	207630496	207630517	206765772	206765793	83015	hg19					enhancer	enh				GCTGGGCGGCCCAGCTGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.450740843									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7286	chr2	207630501	207630522	206765777	206765798	83016	hg19					enhancer	enh				GCGGCCCAGCTGCGGAAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				0.091367215									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7287	chr2	207630508	207630528	206765784	206765804	83017	hg19					enhancer	enh				GAGCCTGTCCTTCCGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FASTKD2	indirect	Non Significant	NA				-0.009801093									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99062	chr2	208394637	208394658	207529913	207529934	83018	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GCACTCGGCACTGGGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				-0.150517438	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394649	208394670	207529925	207529946	83019	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GGGCGGCGCTGGCTGGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				-0.5366312	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394650	208394670	207529926	207529946	83020	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GGCGGCGCTGGCTGGCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	direct	Highly Significant	NA				0.585373043	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394671	208394691	207529947	207529967	83021	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GGCTGCGGCTCCTCAGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				0.163580915	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394672	208394694	207529948	207529970	83022	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GCTGCGGCTCCTCAGTCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				-0.646912014	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394684	208394704	207529960	207529980	83023	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GCAGCAGCCGCCGCCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				0.146915979	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394702	208394724	207529978	207530000	83024	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GCTGCCTGTGGCCCGGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				-1.116345646	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394733	208394755	207530009	207530031	83025	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GGAGTGTTGGTGAGTGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	direct	Highly Significant	NA				0.30203456	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394734	208394755	207530010	207530031	83026	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GAGTGTTGGTGAGTGACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				0.193589589	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394753	208394773	207530029	207530049	83027	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GGCGGAGGTGTAGTTTGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				-0.406198535	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-99062	chr2	208394765	208394785	207530041	207530061	83028	hg19	N/A	enh6130	N/A	N/A	enhancer	enh				GTTTGACGCGGTGTGTTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CREB1	indirect	Non Significant	NA				0.138854713	CREB1	chr2	207529736	207605988	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	10988
enhrx-lit7288	chr2	208489890	208489911	207625166	207625187	83029	hg19					enhancer	enh				GTATGGCCTGGGGATCCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.14505791									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7289	chr2	208489903	208489925	207625179	207625201	83030	hg19					enhancer	enh				GCTCACGGCGCCCCGTATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.299481151									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7290	chr2	208489908	208489930	207625184	207625206	83031	hg19					enhancer	enh				GGGCAGCTCACGGCGCCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.006814504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7291	chr2	208489908	208489928	207625184	207625204	83032	hg19					enhancer	enh				GCAGCTCACGGCGCCCCGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.281319573									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7292	chr2	208489920	208489940	207625196	207625216	83033	hg19					enhancer	enh				GTGCTCCGCCGGGCAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.029907956									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7293	chr2	208489923	208489943	207625199	207625219	83034	hg19					enhancer	enh				GCTGCCCGGCGGAGCACCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				0.138078845									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7294	chr2	208489931	208489952	207625207	207625228	83035	hg19					enhancer	enh				GGCGAGCCCTGGGTGCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.326151185									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7295	chr2	208489931	208489951	207625207	207625227	83036	hg19					enhancer	enh				GCGAGCCCTGGGTGCTCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.235383273									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7296	chr2	208489936	208489957	207625212	207625233	83037	hg19					enhancer	enh				GCACCCAGGGCTCGCCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.202006927									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7297	chr2	208489942	208489962	207625218	207625238	83038	hg19					enhancer	enh				GCCCGGCCTGGGCGAGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.248237871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7298	chr2	208489953	208489973	207625229	207625249	83039	hg19					enhancer	enh				GCGGCGCCTCAGCCCGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				0.001797969									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7299	chr2	208489958	208489978	207625234	207625254	83040	hg19					enhancer	enh				GGGCTGAGGCGCCGCCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	direct	Highly Significant	NA				0.220742982									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7300	chr2	208489971	208489992	207625247	207625268	83041	hg19					enhancer	enh				GCCACGCCGGTACTTACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.140593329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7301	chr2	208489972	208489992	207625248	207625268	83042	hg19					enhancer	enh				GGCCGTAAGTACCGGCGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				0.076139168									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7302	chr2	208489976	208489996	207625252	207625272	83043	hg19					enhancer	enh				GCCGGTACTTACGGCCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				0.024260751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7303	chr2	208489980	208490000	207625256	207625276	83044	hg19					enhancer	enh				GCCTCCCGGGCCGTAAGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.449917145									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7304	chr2	208489994	208490015	207625270	207625291	83045	hg19					enhancer	enh				GCTCCACGCGGGACCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.518155379									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7305	chr2	208490006	208490026	207625282	207625302	83046	hg19					enhancer	enh				GCGGAGCGCGCGCTCCACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	METTL21A	indirect	Non Significant	NA				-0.331530274									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7306	chr2	208634300	208634320	207769576	207769596	83047	hg19					enhancer	enh				GAGCGCGCCTGGCAGCACCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-0.151562303									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7307	chr2	208634306	208634327	207769582	207769603	83048	hg19					enhancer	enh				GCCTGGCAGCACCTGGGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				0.115456371									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7308	chr2	208634311	208634331	207769587	207769607	83049	hg19					enhancer	enh				GCAGCACCTGGGCGGGAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-0.928550538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7309	chr2	208634370	208634390	207769646	207769666	83050	hg19					enhancer	enh				GCACCGCGAGCAGCCGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-0.155164446									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7310	chr2	208634375	208634395	207769651	207769671	83051	hg19					enhancer	enh				GCGAGCAGCCGGCGCTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	direct	Highly Significant	NA				0.51523919									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7311	chr2	208634379	208634399	207769655	207769675	83052	hg19					enhancer	enh				GCAGCCGGCGCTGGCCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-0.63724848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7312	chr2	208634386	208634408	207769662	207769684	83053	hg19					enhancer	enh				GCAGTCCCGGCCTGGCCAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	direct	Highly Significant	NA				0.271943043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7313	chr2	208634388	208634409	207769664	207769685	83054	hg19					enhancer	enh				GCTGGCCAGGCCGGGACTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-1.164934026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7314	chr2	208634396	208634417	207769672	207769693	83055	hg19					enhancer	enh				GCTCACCATGCAGTCCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				0.041704725									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7315	chr2	208634397	208634419	207769673	207769695	83056	hg19					enhancer	enh				GCCGGGACTGCATGGTGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	direct	Highly Significant	NA				0.439018651									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7316	chr2	208634401	208634423	207769677	207769699	83057	hg19					enhancer	enh				GCCGGCGCTCACCATGCAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				-0.01941632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7317	chr2	208634438	208634460	207769714	207769736	83058	hg19					enhancer	enh				GCCGCTCGCCTCCTCCCCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FZD5	indirect	Non Significant	NA				0.197491925									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7318	chr2	211341237	211341257	210476513	210476533	83059	hg19					enhancer	enh				GGGCCATCGAGCCGTCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	direct	Highly Significant	NA				0.364974657									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7319	chr2	211341243	211341263	210476519	210476539	83060	hg19					enhancer	enh				GGACCGCCGAGACGGCTCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.09432316									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7320	chr2	211341251	211341271	210476527	210476547	83061	hg19					enhancer	enh				GTCCACTCGGACCGCCGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	direct	Highly Significant	NA				0.352709218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7321	chr2	211341328	211341349	210476604	210476625	83062	hg19					enhancer	enh				GTCCGGGTGGGTTAAGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.450144072									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7322	chr2	211341345	211341367	210476621	210476643	83063	hg19					enhancer	enh				GCAAAACGGGGCCTCTTTGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	direct	Highly Significant	NA				0.370938669									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7323	chr2	211341359	211341379	210476635	210476655	83064	hg19					enhancer	enh				GGGAACGGGGTTGCAAAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.033318611									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7324	chr2	211341359	211341381	210476635	210476657	83065	hg19					enhancer	enh				GTGGGAACGGGGTTGCAAAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.275157733									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7325	chr2	211341385	211341406	210476661	210476682	83066	hg19					enhancer	enh				GGCGCACTTGCTTCAAGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.274922487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7326	chr2	211341385	211341405	210476661	210476681	83067	hg19					enhancer	enh				GCGCACTTGCTTCAAGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	direct	Highly Significant	NA				0.384058425									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7327	chr2	211341386	211341406	210476662	210476682	83068	hg19					enhancer	enh				GGCGCACTTGCTTCAAGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.132422549									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7328	chr2	211341407	211341427	210476683	210476703	83069	hg19					enhancer	enh				GAAGGGCTTCAGGACGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.145712089									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7329	chr2	211341412	211341434	210476688	210476710	83070	hg19					enhancer	enh				GTCCTGAAGCCCTTCTCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				0.069844701									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7330	chr2	211341424	211341445	210476700	210476721	83071	hg19					enhancer	enh				GTGAGAGGCCAGGGCCGAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.439415172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7331	chr2	211341448	211341470	210476724	210476746	83072	hg19					enhancer	enh				GCAGCCCCGGACAGTAACAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	direct	Highly Significant	NA				0.259486627									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7332	chr2	211341448	211341469	210476724	210476745	83073	hg19					enhancer	enh				GCAGCCCCGGACAGTAACAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	LANCL1	indirect	Non Significant	NA				-0.696491563									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99530	chr2	216973943	216973963	216109220	216109240	83074	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GGCCGGAATCTGCGCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.077382164	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974089	216974109	216109366	216109386	83075	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GTGTCGCAACTCGCTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.014388361	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974091	216974112	216109368	216109389	83076	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GGAAGCGAGTTGCGACACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				0.131167174	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974092	216974112	216109369	216109389	83077	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GAAGCGAGTTGCGACACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.757598957	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974102	216974123	216109379	216109400	83078	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GCGACACGGCAGGTTCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.654311795	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974120	216974142	216109397	216109419	83079	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GCTTTGGTCGCTTCTTCCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.110349722	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974121	216974142	216109398	216109419	83080	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GCTTTGGTCGCTTCTTCCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.140051116	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974125	216974147	216109402	216109424	83081	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GAAGAAGCGACCAAAGCGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.630792612	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974131	216974152	216109408	216109429	83082	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GCGACCAAAGCGCCTGAGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.584216773	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974140	216974160	216109417	216109437	83083	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GCGCCTGAGGACCGGCAACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.940725253	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974148	216974170	216109425	216109447	83084	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GGACCGGCAACATGGTGCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-2.552688311	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974149	216974171	216109426	216109448	83085	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GACCGGCAACATGGTGCGGTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.632796817	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974149	216974170	216109426	216109447	83086	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GACCGGCAACATGGTGCGGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.47616388	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974173	216974195	216109450	216109472	83087	hg19	N/A	enh6149	N/A	N/A	enhancer	enh				GAATAAGGTATAAAGAAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	direct	Highly Significant	NA				0.90200595	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974173	216974195	216109450	216109472	83088	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GAATAAGGTATAAAGAAAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	direct	Highly Significant	NA				0.90200595	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974180	216974201	216109457	216109478	83089	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GTATAAAGAAAGCCATGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	direct	Highly Significant	NA				0.402530481	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974191	216974212	216109468	216109489	83090	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GCCATGGACTTGGGCTTTACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-1.200102885	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974196	216974217	216109473	216109494	83091	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GGACTTGGGCTTTACCCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				0.173431961	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974197	216974217	216109474	216109494	83092	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GACTTGGGCTTTACCCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	direct	Highly Significant	NA				0.278886897	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99530	chr2	216974204	216974225	216109481	216109502	83093	hg19	N/A	enh6149	N/A	Enhatls106482	enhancer	enh				GCTTTACCCGGACTGGGGATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	XRCC5	indirect	Non Significant	NA				-0.380827221	XRCC5	chr2	216107463	216206303	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11456
enhrx-99668	chr2	219258676	219258697	218393953	218393974	83094	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGCCCACAACCTGATAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.84682841	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258676	219258697	218393953	218393974	83095	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGCCCACAACCTGATAAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.84682841	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258784	219258805	218394061	218394082	83096	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCTCAGAATATGGCAAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.884357846	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258784	219258805	218394061	218394082	83097	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCTCAGAATATGGCAAGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.884357846	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258785	219258805	218394062	218394082	83098	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCTCAGAATATGGCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.881916162	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258785	219258805	218394062	218394082	83099	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCTCAGAATATGGCAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.881916162	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258794	219258815	218394071	218394092	83100	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGAATTCTGCCTCAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.316026865	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258794	219258815	218394071	218394092	83101	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGAATTCTGCCTCAGAATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.316026865	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258800	219258820	218394077	218394097	83102	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGCAGAATTCCTCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.042287064	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258800	219258820	218394077	218394097	83103	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGCAGAATTCCTCAGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.042287064	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258814	219258835	218394091	218394112	83104	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGCAGCAGGAGCCTAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.310270681	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258814	219258835	218394091	218394112	83105	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGCAGCAGGAGCCTAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.310270681	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258840	219258862	218394117	218394139	83106	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGCAGCACGGCGAACGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.096848661	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258840	219258862	218394117	218394139	83107	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGCAGCACGGCGAACGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.096848661	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258840	219258861	218394117	218394138	83108	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCAGCACGGCGAACGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-1.046958308	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258840	219258861	218394117	218394138	83109	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCAGCACGGCGAACGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-1.046958308	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258841	219258861	218394118	218394138	83110	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCAGCACGGCGAACGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.138006356	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258841	219258861	218394118	218394138	83111	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCAGCACGGCGAACGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.138006356	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258847	219258867	218394124	218394144	83112	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGATGGGCAGCACGGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.024455003	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258847	219258867	218394124	218394144	83113	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGATGGGCAGCACGGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.024455003	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258847	219258869	218394124	218394146	83114	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGATGGGCAGCACGGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.525878202	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258847	219258869	218394124	218394146	83115	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGATGGGCAGCACGGCGAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.525878202	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258848	219258869	218394125	218394146	83116	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGATGGGCAGCACGGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.654985859	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258848	219258869	218394125	218394146	83117	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAGGATGGGCAGCACGGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.654985859	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258855	219258875	218394132	218394152	83118	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAACGTGAGGATGGGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.468864014	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258855	219258875	218394132	218394152	83119	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GAACGTGAGGATGGGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	direct	Highly Significant	NA				0.468864014	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258863	219258885	218394140	218394162	83120	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCATGCTGGTGAACGTGAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				0.122250567	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258863	219258885	218394140	218394162	83121	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCATGCTGGTGAACGTGAGGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				0.122250567	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258868	219258889	218394145	218394166	83122	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GTGGGCATGCTGGTGAACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.086606793	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258868	219258889	218394145	218394166	83123	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GTGGGCATGCTGGTGAACGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.086606793	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258888	219258908	218394165	218394185	83124	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGCAAACTCCTGCATGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.193286206	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258888	219258908	218394165	218394185	83125	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GGCAAACTCCTGCATGAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.193286206	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258892	219258914	218394169	218394191	83126	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCATTGGCAAACTCCTGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.25807397	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258892	219258914	218394169	218394191	83127	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GCCATTGGCAAACTCCTGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				-0.25807397	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258935	219258956	218394212	218394233	83128	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GTGGTGATGCAATCCAGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				0.170408109	SLC11A1	chr2	218382272	218396894	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99668	chr2	219258935	219258956	218394212	218394233	83129	hg19	N/A	enh6155	N/A	N/A	enhancer	enh				GTGGTGATGCAATCCAGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SLC11A1	indirect	Non Significant	NA				0.170408109	CTDSP1	chr2	218397135	218405941	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11594
enhrx-99672	chr2	219288405	219288426	218423682	218423703	83130	hg19	N/A	N/A	N/A	Enhatls106658	enhancer	enh				GCACTGTTGGGAGTTCTCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				-0.272328046	VIL1	chr2	218419120	218453295	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11598
enhrx-99672	chr2	219288410	219288430	218423687	218423707	83131	hg19	N/A	N/A	N/A	Enhatls106658	enhancer	enh				GTTGGGAGTTCTCTAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				-0.155513715	VIL1	chr2	218419120	218453295	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11598
enhrx-lit7333	chr2	219288521	219288543	218423798	218423820	83132	hg19					enhancer	enh				GATGTTGAGAGAGCCTTTGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				-0.68034797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7334	chr2	219288529	219288551	218423806	218423828	83133	hg19					enhancer	enh				GCTCTCTCAACATCACCACCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				0.054943541									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7335	chr2	219288529	219288550	218423806	218423827	83134	hg19					enhancer	enh				GCTCTCTCAACATCACCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				0.13073461									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7336	chr2	219288552	219288574	218423829	218423851	83135	hg19					enhancer	enh				GGGCTGCAGATATGGAGGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	direct	Highly Significant	NA				0.255809159									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7337	chr2	219288554	219288574	218423831	218423851	83136	hg19					enhancer	enh				GCTGCAGATATGGAGGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				-0.015751125									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7338	chr2	219288557	219288579	218423834	218423856	83137	hg19					enhancer	enh				GCAGATATGGAGGATCGAGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	direct	Highly Significant	NA				0.491146216									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7339	chr2	219288575	219288597	218423852	218423874	83138	hg19					enhancer	enh				GGTGAGGCCCTGTCTGGGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	indirect	Non Significant	NA				-0.142415758									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7340	chr2	219288576	219288597	218423853	218423874	83139	hg19					enhancer	enh				GTGAGGCCCTGTCTGGGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	direct	Highly Significant	NA				0.558850777									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7341	chr2	219288648	219288669	218423925	218423946	83140	hg19					enhancer	enh				GAGGAAACGAAGAGAAATCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	VIL1	direct	Highly Significant	NA				0.411638219									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7342	chr2	220083484	220083504	219218762	219218782	83141	hg19					enhancer	enh				GCCTTGGCTCACGTAGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.400906292									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7343	chr2	220083499	220083521	219218777	219218799	83142	hg19					enhancer	enh				GCCGCTGGGCGCCAAGCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	direct	Highly Significant	NA				0.372777078									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7344	chr2	220083523	220083543	219218801	219218821	83143	hg19					enhancer	enh				GTCCCGGGAAGGGACGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.170922864									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7345	chr2	220083529	220083549	219218807	219218827	83144	hg19					enhancer	enh				GGAAGGGACGCACGTGGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.179684312									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7346	chr2	220083626	220083646	219218904	219218924	83145	hg19					enhancer	enh				GCCCCGCTGGCTCTGGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	direct	Highly Significant	NA				0.292201781									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7347	chr2	220083630	220083652	219218908	219218930	83146	hg19					enhancer	enh				GGTCCCGGGCCCAGAGCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.032924674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7348	chr2	220083630	220083651	219218908	219218929	83147	hg19					enhancer	enh				GTCCCGGGCCCAGAGCCAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.041811196									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7349	chr2	220083653	220083674	219218931	219218952	83148	hg19					enhancer	enh				GTGGGCCTGCAGTTGGCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.067193155									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7350	chr2	220083654	220083674	219218932	219218952	83149	hg19					enhancer	enh				GTGGGCCTGCAGTTGGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.154992902									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7351	chr2	220083661	220083682	219218939	219218960	83150	hg19					enhancer	enh				GCATTCCCGTGGGCCTGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.039470366									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7352	chr2	220083672	220083694	219218950	219218972	83151	hg19					enhancer	enh				GTCCAACACCGAGCATTCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.175066957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7353	chr2	220083734	220083754	219219012	219219032	83152	hg19					enhancer	enh				GCCAATGGGAGCCGTGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.417343271									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7354	chr2	220083740	220083762	219219018	219219040	83153	hg19					enhancer	enh				GACATTTGGCCAATGGGAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.192620696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7355	chr2	220083839	220083859	219219117	219219137	83154	hg19					enhancer	enh				GTCGTCAGATTTCCCGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.653956511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7356	chr2	220094273	220094294	219229551	219229572	83155	hg19					enhancer	enh				GCGGAGCCTCTGGAATCACCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.244604431									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7357	chr2	220094284	220094305	219229562	219229583	83156	hg19					enhancer	enh				GAGCGGAGCCGGCGGAGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.037864262									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7358	chr2	220094284	220094304	219229562	219229582	83157	hg19					enhancer	enh				GAGGCTCCGCCGGCTCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-2.446405836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7359	chr2	220094293	220094313	219229571	219229591	83158	hg19					enhancer	enh				GCCGAGCCGAGCGGAGCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-1.474140249									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7360	chr2	220094310	220094331	219229588	219229609	83159	hg19					enhancer	enh				GGCTCGGCTCGGCGCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.05655873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7361	chr2	220094311	220094331	219229589	219229609	83160	hg19					enhancer	enh				GCTCGGCTCGGCGCGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	direct	Highly Significant	NA				0.211975967									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7362	chr2	220094320	220094342	219229598	219229620	83161	hg19					enhancer	enh				GGCGCGACCCGCGGCGCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.089300166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7363	chr2	220094321	220094342	219229599	219229620	83162	hg19					enhancer	enh				GCGCGACCCGCGGCGCTAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.261509531									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7364	chr2	220094330	220094350	219229608	219229628	83163	hg19					enhancer	enh				GACACCCGGCCTAGCGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.067523173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7365	chr2	220094331	220094353	219229609	219229631	83164	hg19					enhancer	enh				GCAGACACCCGGCCTAGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.181959726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7366	chr2	220094344	220094366	219229622	219229644	83165	hg19					enhancer	enh				GTGACAGTGAGTGGCAGACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.172171926									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7367	chr2	220094344	220094364	219229622	219229642	83166	hg19					enhancer	enh				GACAGTGAGTGGCAGACACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.171920136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7368	chr2	220094368	220094390	219229646	219229668	83167	hg19					enhancer	enh				GCTTATTGGCCAGCCTGGCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	direct	Highly Significant	NA				0.230313832									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7369	chr2	220094371	220094393	219229649	219229671	83168	hg19					enhancer	enh				GCCAGGCTGGCCAATAAGCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.722133403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7370	chr2	220094371	220094392	219229649	219229670	83169	hg19					enhancer	enh				GCCAGGCTGGCCAATAAGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				0.059492662									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7371	chr2	220094375	220094395	219229653	219229673	83170	hg19					enhancer	enh				GGCTGGCCAATAAGCACGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.499239583									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7372	chr2	220094411	220094432	219229689	219229710	83171	hg19					enhancer	enh				GCCAATTCTCGGCTTCAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.274182037									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7373	chr2	220094428	220094448	219229706	219229726	83172	hg19					enhancer	enh				GGGACGGGACTAAAGTCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				0.056998677									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7374	chr2	220094449	220094469	219229727	219229747	83173	hg19					enhancer	enh				GGCGGGTCTTGGACAGTCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	direct	Highly Significant	NA				1.569008877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7375	chr2	220094471	220094491	219229749	219229769	83174	hg19					enhancer	enh				GCCCAATAGTGTGCTCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.548215586									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7376	chr2	220094483	220094504	219229761	219229782	83175	hg19					enhancer	enh				GCTCTACGTGGGGCGGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.324013871									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7377	chr2	220094499	220094519	219229777	219229797	83176	hg19					enhancer	enh				GGCTCAGGTGCGGACGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.292129104									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7378	chr2	220094518	220094540	219229796	219229818	83177	hg19					enhancer	enh				GAGCAGCGAAGAGGACAACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG9A	indirect	Non Significant	NA				-0.447207448									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7379	chr2	220094518	220094538	219229796	219229816	83178	hg19					enhancer	enh				GCAGCGAAGAGGACAACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				0.118014503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7380	chr2	220094521	220094541	219229799	219229819	83179	hg19					enhancer	enh				GGAGCAGCGAAGAGGACAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.75137703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7381	chr2	220094529	220094549	219229807	219229827	83180	hg19					enhancer	enh				GTCACTACGGAGCAGCGAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	direct	Highly Significant	NA				0.200365188									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7382	chr2	220094551	220094573	219229829	219229851	83181	hg19					enhancer	enh				GGATTGTTGTGTTGCAGAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				0.159356162									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7383	chr2	220094552	220094573	219229830	219229851	83182	hg19					enhancer	enh				GATTGTTGTGTTGCAGAAATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.037993524									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7384	chr2	220094567	220094587	219229845	219229865	83183	hg19					enhancer	enh				GAAATCCGGCAATCGACCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.610494638									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7385	chr2	220094586	220094608	219229864	219229886	83184	hg19					enhancer	enh				GCTGAGCGGCTCGCAAGTCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				0.197602409									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7386	chr2	220094589	220094611	219229867	219229889	83185	hg19					enhancer	enh				GACTTGCGAGCCGCTCAGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	direct	Highly Significant	NA				0.378218634									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7387	chr2	220094612	220094632	219229890	219229910	83186	hg19					enhancer	enh				GAAGACGCACCAAACGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	direct	Highly Significant	NA				0.439515407									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7388	chr2	220094614	220094635	219229892	219229913	83187	hg19					enhancer	enh				GACGTTTGGTGCGTCTTCTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				0.050248281									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7389	chr2	220094621	220094641	219229899	219229919	83188	hg19					enhancer	enh				GGTGCGTCTTCTAAGGGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.117259374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7390	chr2	220094635	220094655	219229913	219229933	83189	hg19					enhancer	enh				GGGCGTGGGCGAGTTTACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKZF1	indirect	Non Significant	NA				-0.165982995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99898	chr2	220252336	220252357	219387614	219387635	83190	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GTCGTCAGGTCACCCTCCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.149217643	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252351	220252371	219387629	219387649	83191	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GAAACCGAAAGCCCCGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-1.615352737	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252402	220252423	219387680	219387701	83192	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GCGCTAAGCTTGGGCCCCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.097210044	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252409	220252429	219387687	219387707	83193	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GCTTGGGCCCCGGAGGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.134657276	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252419	220252440	219387697	219387718	83194	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GACCGGGTCCGGCGCCCTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.177945739	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252437	220252459	219387715	219387737	83195	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GTCTGGGATCGAAATTCAAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.791280753	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252447	220252467	219387725	219387745	83196	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GAAATTCAAGTGGGGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.694361896	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252464	220252485	219387742	219387763	83197	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GTCGGGAGCCACTTACCTGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.024791138	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-99898	chr2	220252475	220252496	219387753	219387774	83198	hg19	N/A	N/A	N/A	Enhatls106883	enhancer	enh				GCGCGGGGCCATGCAGGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.2605907	DNPEP	chr2	219372042	219400022	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11824
enhrx-lit7391	chr2	220252482	220252503	219387760	219387781	83199	hg19					enhancer	enh				GCCCCACGCGCGGGGCCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.127922579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7392	chr2	220252491	220252512	219387769	219387790	83200	hg19					enhancer	enh				GCGGACACAGCCCCACGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.263212454									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7393	chr2	220252493	220252514	219387771	219387792	83201	hg19					enhancer	enh				GAGCGGACACAGCCCCACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.444452113									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7394	chr2	220252496	220252517	219387774	219387795	83202	hg19					enhancer	enh				GTGGGGCTGTGTCCGCTCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.506453361									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7395	chr2	220252504	220252525	219387782	219387803	83203	hg19					enhancer	enh				GTGTCCGCTCATCTGGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.233378836									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7396	chr2	220252504	220252524	219387782	219387802	83204	hg19					enhancer	enh				GTGTCCGCTCATCTGGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.18320236									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7397	chr2	220252510	220252530	219387788	219387808	83205	hg19					enhancer	enh				GCTCATCTGGCCTCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.07878599									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7398	chr2	220252511	220252531	219387789	219387809	83206	hg19					enhancer	enh				GAGCCCGGAGGCCAGATGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				-0.033004449									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7399	chr2	220252604	220252624	219387882	219387902	83207	hg19					enhancer	enh				GAAGGCCTACGAGTGCGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.223181958									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7400	chr2	220252609	220252629	219387887	219387907	83208	hg19					enhancer	enh				GTGATGAAGGCCTACGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	indirect	Non Significant	NA				0.197029711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7401	chr2	220252656	220252677	219387934	219387955	83209	hg19					enhancer	enh				GTGGGCGGGGAGGCCAAACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	DNPEP	direct	Highly Significant	NA				0.203284542									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7402	chr2	220363569	220363589	219498847	219498867	83210	hg19					enhancer	enh				GTCGCGAGAACTCATTCGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.706420595									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7403	chr2	220363586	220363608	219498864	219498886	83211	hg19					enhancer	enh				GACTTGCGAGAAGACACGTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.033263711									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7404	chr2	220363591	220363612	219498869	219498890	83212	hg19					enhancer	enh				GCGAGAAGACACGTGCGCGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.0153979									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7405	chr2	220363605	220363627	219498883	219498905	83213	hg19					enhancer	enh				GCGCGGAAGGAGCTTGCAGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.490896106									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7406	chr2	220363607	220363628	219498885	219498906	83214	hg19					enhancer	enh				GCGGAAGGAGCTTGCAGTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				0.07842465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7407	chr2	220363610	220363631	219498888	219498909	83215	hg19					enhancer	enh				GAAGGAGCTTGCAGTAGCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.058590518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7408	chr2	220363620	220363640	219498898	219498918	83216	hg19					enhancer	enh				GCAGTAGCGGGCGGCAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.50417605									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7409	chr2	220363629	220363649	219498907	219498927	83217	hg19					enhancer	enh				GGCGGCAGAGCTGGAGTGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.445987797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7410	chr2	220363638	220363658	219498916	219498936	83218	hg19					enhancer	enh				GCTGGAGTGAAGGGAGCTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.436725737									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7411	chr2	220363642	220363664	219498920	219498942	83219	hg19					enhancer	enh				GAGTGAAGGGAGCTAGTGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.87450694									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7412	chr2	220363644	220363664	219498922	219498942	83220	hg19					enhancer	enh				GTGAAGGGAGCTAGTGGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				0.04694038									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7413	chr2	220363650	220363671	219498928	219498949	83221	hg19					enhancer	enh				GGAGCTAGTGGTAAAGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.849082882									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7414	chr2	220363651	220363671	219498929	219498949	83222	hg19					enhancer	enh				GAGCTAGTGGTAAAGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.238534526									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7415	chr2	220363699	220363719	219498977	219498997	83223	hg19					enhancer	enh				GGCAGGGGACACCCTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.635953632									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7416	chr2	220363706	220363726	219498984	219499004	83224	hg19					enhancer	enh				GACACCCTCTAGACGGAGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.298352552									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7417	chr2	220363713	220363733	219498991	219499011	83225	hg19					enhancer	enh				GAGCCCGCTCTCCGTCTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.26821415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7418	chr2	220366242	220366263	219501520	219501541	83226	hg19					enhancer	enh				GAACTGGGTGAGGGGCTCATC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.188946881									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7419	chr2	220366259	220366279	219501537	219501557	83227	hg19					enhancer	enh				GTTCCTAGAAGCCGCCCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				0.154819148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7420	chr2	220366277	220366299	219501555	219501577	83228	hg19					enhancer	enh				GACTGGAAGGTTAAACTCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.203253466									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99939	chr2	220366296	220366317	219501574	219501595	83229	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTGTGTGCACAAACACCTGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.294507851	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366307	220366327	219501585	219501605	83230	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTGCACACACTCGTATATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.144231351	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366346	220366366	219501624	219501644	83231	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GCCTCTGAGTTCTTGGAAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.31147444	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366387	220366409	219501665	219501687	83232	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GAGTTCATCCTCGCCTACTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.267447385	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366389	220366409	219501667	219501687	83233	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTTCATCCTCGCCTACTAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.243554572	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366451	220366472	219501729	219501750	83234	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTTTCTCTGTGGGCCTTGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-1.905952916	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366461	220366483	219501739	219501761	83235	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GGGCCTTGGGCAGGAGTAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.32650851	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366462	220366483	219501740	219501761	83236	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GGCCTTGGGCAGGAGTAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.117477149	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366463	220366483	219501741	219501761	83237	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GCCTTGGGCAGGAGTAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.907740393	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366474	220366496	219501752	219501774	83238	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GAGTAGTCCTGGGAGCAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.048560809	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366476	220366496	219501754	219501774	83239	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTAGTCCTGGGAGCAAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				0.068104946	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366479	220366499	219501757	219501777	83240	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTCCTGGGAGCAAGCGGTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.268726161	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366492	220366512	219501770	219501790	83241	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GCGGTGGCGGTCAGGTGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.287469583	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366498	220366519	219501776	219501797	83242	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GCGGTCAGGTGCCCTGGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.017898732	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366513	220366533	219501791	219501811	83243	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GGAAACAGATACCATGAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	direct	Highly Significant	NA				0.402669131	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-99939	chr2	220366527	220366548	219501805	219501826	83244	hg19	N/A	N/A	N/A	Enhatls106927	enhancer	enh				GTTTCCTAAGATCCACTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GMPPA	indirect	Non Significant	NA				-0.272866948	GMPPA	chr2	219498864	219506989	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11865
enhrx-lit7421	chr2	220417263	220417284	219552541	219552562	83245	hg19					enhancer	enh				GAGCCCGCGTCCGCATCCGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.214303033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7422	chr2	220417307	220417328	219552585	219552606	83246	hg19					enhancer	enh				GACCACGGGGCGCTGGGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.516880203									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7423	chr2	220417314	220417334	219552592	219552612	83247	hg19					enhancer	enh				GGTCGAGACCACGGGGCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.274510801									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7424	chr2	220417321	220417342	219552599	219552620	83248	hg19					enhancer	enh				GTGTCGGAGGTCGAGACCACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				0.169363971									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7425	chr2	220417335	220417355	219552613	219552633	83249	hg19					enhancer	enh				GTTCGAGTGCACCGTGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				0.097828913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7426	chr2	220417364	220417385	219552642	219552663	83250	hg19					enhancer	enh				GGTGAGCGCCCGCGAAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.678163742									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7427	chr2	220417364	220417384	219552642	219552662	83251	hg19					enhancer	enh				GTGAGCGCCCGCGAAGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.232936403									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7428	chr2	220417370	220417391	219552648	219552669	83252	hg19					enhancer	enh				GCGGTCGGTGAGCGCCCGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.220908748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7429	chr2	220417374	220417395	219552652	219552673	83253	hg19					enhancer	enh				GGGCGCTCACCGACCGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.354116915									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7430	chr2	220417375	220417395	219552653	219552673	83254	hg19					enhancer	enh				GGCGCTCACCGACCGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.367531613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7431	chr2	220417386	220417406	219552664	219552684	83255	hg19					enhancer	enh				GGTACTCTCCGAGCTGCGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.902551965									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7432	chr2	220417390	220417411	219552668	219552689	83256	hg19					enhancer	enh				GTGGCGGTACTCTCCGAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.302823802									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7433	chr2	220417399	220417420	219552677	219552698	83257	hg19					enhancer	enh				GAGTACCGCCACAGTACGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.5374065									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7434	chr2	220417410	220417431	219552688	219552709	83258	hg19					enhancer	enh				GCTCCGCCCCAGAGCGTACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.087070067									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7435	chr2	220417410	220417432	219552688	219552710	83259	hg19					enhancer	enh				GGCTCCGCCCCAGAGCGTACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.438445327									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7436	chr2	220417492	220417512	219552770	219552790	83260	hg19					enhancer	enh				GACCGCGCGTGCTTCTAGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.819268774									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7437	chr2	220435938	220435960	219571216	219571238	83261	hg19					enhancer	enh				GCCGCGATGAAGGCGAGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.153656715									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7438	chr2	220435961	220435983	219571239	219571261	83262	hg19					enhancer	enh				GCCGACCGCCTGCAGCGGCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.432126487									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7439	chr2	220435968	220435988	219571246	219571266	83263	hg19					enhancer	enh				GCCTGCAGCGGCGAACGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.290529943									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7440	chr2	220436077	220436099	219571355	219571377	83264	hg19					enhancer	enh				GCTCTCCCGGGCCTCCCGCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.152800335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7441	chr2	220436112	220436132	219571390	219571410	83265	hg19					enhancer	enh				GCAGCTCGGGGCCGAGGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				0.010315527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7442	chr2	220436117	220436137	219571395	219571415	83266	hg19					enhancer	enh				GAGCTGCAGCTCGGGGCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.278139117									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7443	chr2	220436118	220436140	219571396	219571418	83267	hg19					enhancer	enh				GCAGAGCTGCAGCTCGGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.737046177									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7444	chr2	220436120	220436142	219571398	219571420	83268	hg19					enhancer	enh				GCCCCGAGCTGCAGCTCTGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				0.081245469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7445	chr2	220436124	220436146	219571402	219571424	83269	hg19					enhancer	enh				GCCGCCGCAGAGCTGCAGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.19909705									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7446	chr2	220436125	220436145	219571403	219571423	83270	hg19					enhancer	enh				GAGCTGCAGCTCTGCGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.314861329									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7447	chr2	220436126	220436146	219571404	219571424	83271	hg19					enhancer	enh				GCCGCCGCAGAGCTGCAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.307808433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7448	chr2	220436152	220436174	219571430	219571452	83272	hg19					enhancer	enh				GGCGATTCCCGGGCCCGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.467450131									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7449	chr2	220436153	220436174	219571431	219571452	83273	hg19					enhancer	enh				GCGATTCCCGGGCCCGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				0.122060136									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7450	chr2	220436162	220436183	219571440	219571461	83274	hg19					enhancer	enh				GGGCCCGAAGCCTGGCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.204501503									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7451	chr2	220436163	220436183	219571441	219571461	83275	hg19					enhancer	enh				GGCCCGAAGCCTGGCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.187914263									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7452	chr2	220436199	220436221	219571477	219571499	83276	hg19					enhancer	enh				GCCACTCGCTGGAGAGGCAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.031145166									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7453	chr2	220436207	220436229	219571485	219571507	83277	hg19					enhancer	enh				GCTGCGGGGCCACTCGCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.274718696									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7454	chr2	220436212	220436233	219571490	219571511	83278	hg19					enhancer	enh				GGAGGCTGCGGGGCCACTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				0.082949055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7455	chr2	220436212	220436232	219571490	219571510	83279	hg19					enhancer	enh				GAGGCTGCGGGGCCACTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.50357355									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7456	chr2	220436224	220436246	219571502	219571524	83280	hg19					enhancer	enh				GCAGCCTCCCCTGCCCGCTGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.201508679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7457	chr2	220436235	220436257	219571513	219571535	83281	hg19					enhancer	enh				GCAGGAAGCCAGGCAGCGGGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.432402771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7458	chr2	220436236	220436257	219571514	219571535	83282	hg19					enhancer	enh				GCAGGAAGCCAGGCAGCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.55450064									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7459	chr2	220436247	220436267	219571525	219571545	83283	hg19					enhancer	enh				GCTCCTAAGAGCAGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.264971254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7460	chr2	220436247	220436268	219571525	219571546	83284	hg19					enhancer	enh				GGCTCCTAAGAGCAGGAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.294111285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7461	chr2	220436255	220436275	219571533	219571553	83285	hg19					enhancer	enh				GAAGAGAGGCTCCTAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.669080502									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7462	chr2	220436255	220436276	219571533	219571554	83286	hg19					enhancer	enh				GGAAGAGAGGCTCCTAAGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.391676757									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7463	chr2	220436284	220436305	219571562	219571583	83287	hg19					enhancer	enh				GAAGAGGCCCAAGCTGTGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.267688594									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7464	chr2	220436330	220436352	219571608	219571630	83288	hg19					enhancer	enh				GCCAGGTCCCCAGCCGCCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.228814375									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7465	chr2	220436341	220436362	219571619	219571640	83289	hg19					enhancer	enh				GCCCAAGCCTGGCGGGCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	direct	Highly Significant	NA				0.355394579									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7466	chr2	220436350	220436371	219571628	219571649	83290	hg19					enhancer	enh				GCCACTCAGGCCCAAGCCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.246229156									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7467	chr2	220436418	220436440	219571696	219571718	83291	hg19					enhancer	enh				GCTGGAGGACAAGAGCCCAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	OBSL1	indirect	Non Significant	NA				-0.566438698									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99964	chr2	220439536	220439556	219574814	219574834	83292	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCTGTGGTTCCACACCGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.070362582	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439541	220439561	219574819	219574839	83293	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GGTTCCACACCGGGCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.314787067	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439548	220439570	219574826	219574848	83294	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCCCTGCCTGTCCAGCCCGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.210955219	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439604	220439626	219574882	219574904	83295	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCCTGCTGGCACTGTCACCGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.066358128	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439612	220439634	219574890	219574912	83296	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCACTGTCACCGGGAGGACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.210097902	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439645	220439665	219574923	219574943	83297	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GGAGCATGGCCCAAAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				0.085417773	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439645	220439666	219574923	219574944	83298	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GGGAGCATGGCCCAAAGACAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.508367311	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439667	220439687	219574945	219574965	83299	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GTGCAGCACGGCCCAGTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.080348442	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439668	220439688	219574946	219574966	83300	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GGTGCAGCACGGCCCAGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				0.026120402	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439679	220439701	219574957	219574979	83301	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCAGAGGTGGCCAGGTGCAGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				1.084884593	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439718	220439739	219574996	219575017	83302	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCAGCAGCACCAGGACGGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.284780672	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439719	220439739	219574997	219575017	83303	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GCAGCAGCACCAGGACGGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.364391573	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439754	220439775	219575032	219575053	83304	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GTACCTGCTCAGCCCGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.038441911	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439760	220439780	219575038	219575058	83305	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GGCCTCAGGCCGGGCTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.252630244	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439769	220439789	219575047	219575067	83306	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GAAGGGCGTGGCCTCAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	direct	Highly Significant	NA				0.24888768	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439781	220439801	219575059	219575079	83307	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GTGGGCCACCAGGAAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.400878789	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439787	220439809	219575065	219575087	83308	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GTCCGAGTGTGGGCCACCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.270919343	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439806	220439826	219575084	219575104	83309	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GACCAGACCACCCAGTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.689127362	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-99964	chr2	220439838	220439860	219575116	219575138	83310	hg19	N/A	enh19248	N/A	N/A	enhancer	enh				GACATCAGGGGAGTTGAGCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	INHA	indirect	Non Significant	NA				-0.336877402	INHA	chr2	219572309	219575711	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11890
enhrx-lit7468	chr2	220462486	220462507	219597764	219597785	83311	hg19					enhancer	enh				GATCATGCAAACGAATCGAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.377181984									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7469	chr2	220462503	220462524	219597781	219597802	83312	hg19					enhancer	enh				GATCTACGGCGCGGTTTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.297960349									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7470	chr2	220462544	220462566	219597822	219597844	83313	hg19					enhancer	enh				GAAAATCGAGCCAAGGGACGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.419351766									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7471	chr2	220462553	220462575	219597831	219597853	83314	hg19					enhancer	enh				GCCCCGGAAGAAAATCGAGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.599575287									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7472	chr2	220462571	220462592	219597849	219597870	83315	hg19					enhancer	enh				GATGGAAAGGAAGTCCCGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				0.117802724									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7473	chr2	220462585	220462605	219597863	219597883	83316	hg19					enhancer	enh				GGCGCCTATCAATGATGGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.287632623									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7474	chr2	220462590	220462612	219597868	219597890	83317	hg19					enhancer	enh				GCTGCCCGGCGCCTATCAATGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				0.191515447									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7475	chr2	220462595	220462617	219597873	219597895	83318	hg19					enhancer	enh				GATAGGCGCCGGGCAGCTGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.328695848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7476	chr2	220462613	220462635	219597891	219597913	83319	hg19					enhancer	enh				GAGCTGGTAGGAGGACCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.249276888									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7477	chr2	220462615	220462635	219597893	219597913	83320	hg19					enhancer	enh				GCTGGTAGGAGGACCAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.422179593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-99966	chr2	220462631	220462652	219597909	219597930	83321	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GACATACCGAACCTCCCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				0.060424942	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462636	220462657	219597914	219597935	83322	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GGAGGTTCGGTATGTCTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.54825181	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462637	220462657	219597915	219597935	83323	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GAGGTTCGGTATGTCTGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.308414201	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462658	220462680	219597936	219597958	83324	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GGACTTATGTTCCTCGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.286262881	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462659	220462680	219597937	219597958	83325	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GACTTATGTTCCTCGAAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.130249387	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462666	220462688	219597944	219597966	83326	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GTTCCTCGAAAGGGCGGCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				1.349474261	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462728	220462748	219598006	219598026	83327	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GCATGACGCCTCGGTTTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	direct	Highly Significant	NA				0.22166823	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-99966	chr2	220462735	220462757	219598013	219598035	83328	hg19	N/A	N/A	N/A	Enhatls106953	enhancer	enh				GCCTCGGTTTGCGCGGACGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	STK11IP	indirect	Non Significant	NA				-0.036119565	STK11IP	chr2	219597856	219616451	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	11892
enhrx-lit7478	chr2	223725576	223725596	222860858	222860878	83329	hg19					enhancer	enh				GGTTACTACGGGTCATTCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.734842357									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7479	chr2	223725587	223725607	222860869	222860889	83330	hg19					enhancer	enh				GGGCGGGGCGAGGTTACTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.761041703									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7480	chr2	223725624	223725645	222860906	222860927	83331	hg19					enhancer	enh				GCTCCCCGGCCCGAATTCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.021606202									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7481	chr2	223725630	223725650	222860912	222860932	83332	hg19					enhancer	enh				GGCCTATCGAATTCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.410241679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7482	chr2	223725663	223725683	222860945	222860965	83333	hg19					enhancer	enh				GCCACCGCTCGCGGGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.247050624									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7483	chr2	223725670	223725690	222860952	222860972	83334	hg19					enhancer	enh				GCCACCCATTGGCCCGCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	direct	Highly Significant	NA				0.304094374									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7484	chr2	223725699	223725720	222860981	222861002	83335	hg19					enhancer	enh				GCATAGGCAACGAGTGCCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	direct	Highly Significant	NA				0.438124514									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7485	chr2	223725736	223725757	222861018	222861039	83336	hg19					enhancer	enh				GTCTGTTGAGCGGAACCGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.328894523									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7486	chr2	223725737	223725757	222861019	222861039	83337	hg19					enhancer	enh				GTCTGTTGAGCGGAACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.505403191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7487	chr2	223725737	223725759	222861019	222861041	83338	hg19					enhancer	enh				GCGTCTGTTGAGCGGAACCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.714939679									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7488	chr2	223725747	223725768	222861029	222861050	83339	hg19					enhancer	enh				GCCACAGCAGCGTCTGTTGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-1.205312879									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7489	chr2	223725754	223725774	222861036	222861056	83340	hg19					enhancer	enh				GACGCTGCTGTGGCTGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.523391686									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7490	chr2	223725775	223725796	222861057	222861078	83341	hg19					enhancer	enh				GACAACTGCAGTGTCGCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.52047938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7491	chr2	223725779	223725800	222861061	222861082	83342	hg19					enhancer	enh				GCGACACTGCAGTTGTCTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				0.045166683									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7492	chr2	223725790	223725811	222861072	222861093	83343	hg19					enhancer	enh				GTTGTCTACGCGGCCGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.180302071									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7493	chr2	223725790	223725810	222861072	222861092	83344	hg19					enhancer	enh				GTTGTCTACGCGGCCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				-0.012738739									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7494	chr2	223725853	223725874	222861135	222861156	83345	hg19					enhancer	enh				GCTGTCGGGGCCGCAATGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				0.075429534									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7495	chr2	223725896	223725916	222861178	222861198	83346	hg19					enhancer	enh				GGCGCGGGGCGTGAACGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ACSL3	indirect	Non Significant	NA				0.04643088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7496	chr2	231084590	231084611	230219875	230219896	83347	hg19					enhancer	enh				GGAACGACAAACTCAAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	direct	Highly Significant	NA				0.61858985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7497	chr2	231084590	231084610	230219875	230219895	83348	hg19					enhancer	enh				GAACGACAAACTCAAAGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.970922936									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7498	chr2	231084603	231084624	230219888	230219909	83349	hg19					enhancer	enh				GTCGTTCCTGCCCCTTTCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.011497335									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7499	chr2	231084612	231084634	230219897	230219919	83350	hg19					enhancer	enh				GTCCCAGCCCCTGGAAAGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	direct	Highly Significant	NA				0.964192031									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7500	chr2	231084631	231084653	230219916	230219938	83351	hg19					enhancer	enh				GACAGGGATCACTCCTCAAGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				0.131423415									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7501	chr2	231084658	231084679	230219943	230219964	83352	hg19					enhancer	enh				GAGTTACAGGGAGATGCTAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	direct	Highly Significant	NA				0.619076388									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7502	chr2	231084666	231084688	230219951	230219973	83353	hg19					enhancer	enh				GGGAGATGCTAGCAGGCAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.558326432									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7503	chr2	231084667	231084688	230219952	230219973	83354	hg19					enhancer	enh				GGAGATGCTAGCAGGCAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.248125887									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7504	chr2	231084668	231084688	230219953	230219973	83355	hg19					enhancer	enh				GAGATGCTAGCAGGCAAAAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.774934237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7505	chr2	231084697	231084718	230219982	230220003	83356	hg19					enhancer	enh				GTGCTTTGACAAACGCAGTAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.288950896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7506	chr2	231084697	231084717	230219982	230220002	83357	hg19					enhancer	enh				GTGCTTTGACAAACGCAGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.516347419									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7507	chr2	231084699	231084719	230219984	230220004	83358	hg19					enhancer	enh				GCTTTGACAAACGCAGTAAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	direct	Highly Significant	NA				0.248318359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7508	chr2	231084704	231084724	230219989	230220009	83359	hg19					enhancer	enh				GACAAACGCAGTAAGGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	direct	Highly Significant	NA				0.650883372									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7509	chr2	231084759	231084780	230220044	230220065	83360	hg19					enhancer	enh				GTTTGCCAAGCCGGAAGCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.44773486									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7510	chr2	231084767	231084789	230220052	230220074	83361	hg19					enhancer	enh				GACCTGCCTTCAGCTTCCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.149963158									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7511	chr2	231084816	231084836	230220101	230220121	83362	hg19					enhancer	enh				GAGCCTCACAAGTGCCCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.405725211									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7512	chr2	231084832	231084854	230220117	230220139	83363	hg19					enhancer	enh				GCTCCCAGGACGTCTTGGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SP110	indirect	Non Significant	NA				-0.953375326									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7513	chr2	231577529	231577549	230712814	230712834	83364	hg19					enhancer	enh				GCCCGACGTCGCGTCCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				0.074249095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7514	chr2	231577533	231577553	230712818	230712838	83365	hg19					enhancer	enh				GCCGCCGAGGACGCGACGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.319609939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7515	chr2	231577534	231577556	230712819	230712841	83366	hg19					enhancer	enh				GCAGCCGCCGAGGACGCGACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	direct	Highly Significant	NA				0.32259704									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7516	chr2	231577546	231577567	230712831	230712852	83367	hg19					enhancer	enh				GTGCGCACTGCGCAGCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				0.126430835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7517	chr2	231577554	231577575	230712839	230712860	83368	hg19					enhancer	enh				GCGCAGTGCGCACGTCAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.150798664									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7518	chr2	231577556	231577576	230712841	230712861	83369	hg19					enhancer	enh				GCAGTGCGCACGTCAAAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				0.044771947									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7519	chr2	231577561	231577582	230712846	230712867	83370	hg19					enhancer	enh				GCGCACGTCAAAGCCGGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-1.270748024									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7520	chr2	231577561	231577581	230712846	230712866	83371	hg19					enhancer	enh				GCGCACGTCAAAGCCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.298305513									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7521	chr2	231577573	231577594	230712858	230712879	83372	hg19					enhancer	enh				GCCGGGCTCGGGCCGCAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				0.00770343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7522	chr2	231577573	231577593	230712858	230712878	83373	hg19					enhancer	enh				GCCGGGCTCGGGCCGCAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.43125363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7523	chr2	231577628	231577648	230712913	230712933	83374	hg19					enhancer	enh				GACACAGAGCCTTCAGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.21247893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7524	chr2	231577634	231577655	230712919	230712940	83375	hg19					enhancer	enh				GAGCCTTCAGGCGCCGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	direct	Highly Significant	NA				0.222377748									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7525	chr2	231577657	231577677	230712942	230712962	83376	hg19					enhancer	enh				GGCACAGGCGAAGACTAAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	CAB39	indirect	Non Significant	NA				-0.426413091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7526	chr2	233498271	233498293	232633561	232633583	83377	hg19					enhancer	enh				GTCCTCAGACCCTCCCAACCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.070146291									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7527	chr2	233498306	233498328	232633596	232633618	83378	hg19					enhancer	enh				GCTCTACAACACTCCGCCGAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				0.068409749									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7528	chr2	233498309	233498329	232633599	232633619	83379	hg19					enhancer	enh				GGCTCTACAACACTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				0.103904427									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7529	chr2	233498309	233498331	232633599	232633621	83380	hg19					enhancer	enh				GAGGCTCTACAACACTCCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	direct	Highly Significant	NA				0.278050254									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7530	chr2	233498318	233498340	232633608	232633630	83381	hg19					enhancer	enh				GTTGTAGAGCCTCGAGCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.28828877									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7531	chr2	233498330	233498351	232633620	232633641	83382	hg19					enhancer	enh				GGCGCGCTCCTCGCAGGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				0.164100043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7532	chr2	233498330	233498350	232633620	232633640	83383	hg19					enhancer	enh				GCGCGCTCCTCGCAGGCTCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.153022079									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7533	chr2	233498387	233498407	232633677	232633697	83384	hg19					enhancer	enh				GATCGCAGGACGCGGGAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.174561646									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7534	chr2	233498394	233498415	232633684	232633705	83385	hg19					enhancer	enh				GCGTCCTGCGATCCGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.005444528									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7535	chr2	233498403	233498424	232633693	232633714	83386	hg19					enhancer	enh				GATCCGCCGCCATGGCCAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	direct	Highly Significant	NA				0.423547795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7536	chr2	233498409	233498430	232633699	232633720	83387	hg19					enhancer	enh				GCTCCTCACTGGCCATGGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	EFHD1	indirect	Non Significant	NA				-0.488812246									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7537	chr2	233740986	233741008	232876276	232876298	83388	hg19					enhancer	enh				GCCAGCAGGGCGGCGATCACGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.602341786									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-100698	chr2	233741093	233741114	232876383	232876404	83389	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GAGTGCAGCCGAGTCGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.044057057	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741116	233741137	232876406	232876427	83390	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCGCGGACATACAGGCGCGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.443737818	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741125	233741147	232876415	232876437	83391	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GGACACGCACGCGCGGACATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.145779063	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741125	233741146	232876415	232876436	83392	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GACACGCACGCGCGGACATAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.800343524	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741134	233741155	232876424	232876445	83393	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCATGCGCGGACACGCACGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.392083233	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741135	233741155	232876425	232876445	83394	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCGTGCGTGTCCGCGCATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.173963368	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741148	233741169	232876438	232876459	83395	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCTCTGGCACACCTGCATGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.241314847	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741159	233741181	232876449	232876471	83396	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GTGCCAGAGCGTGAGCGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-1.780126533	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741161	233741181	232876451	232876471	83397	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCCAGAGCGTGAGCGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.777636927	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741165	233741185	232876455	232876475	83398	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCCTGCGCGCGCTCACGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.034793834	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741173	233741194	232876463	232876484	83399	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCGCGCGCAGGCGAGCGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.347661556	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741173	233741193	232876463	232876483	83400	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCGCGCGCAGGCGAGCGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.630864417	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741179	233741199	232876469	232876489	83401	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCAGGCGAGCGCTCAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.248050493	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741217	233741237	232876507	232876527	83402	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GCGTGCACGGCACCCACCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	indirect	Non Significant	NA				-0.03478779	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741220	233741241	232876510	232876531	83403	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GTGGGTGCCGTGCACGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.332286519	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741229	233741249	232876519	232876539	83404	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GTGCACGCGCGCGGGTCCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.29468233	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100698	chr2	233741250	233741270	232876540	232876560	83405	hg19	N/A	N/A	N/A	Enhatls107723	enhancer	enh				GGCGCGCCCGAATTCCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	C2orf82	direct	Highly Significant	NA				0.432437012	SNORC	chr2	232857269	232878700	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12624
enhrx-100879	chr2	234762995	234763017	233854349	233854371	83406	hg19	N/A	N/A	N/A	Enhatls107916	enhancer	enh				GCCTCCCCTCCCGGCGGACCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-0.196088403	HJURP	chr2	233836700	233854566	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	12805
enhrx-lit7538	chr2	234763079	234763101	233854433	233854455	83407	hg19					enhancer	enh				GACCAGCTGCTGCAGAAGCTCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.182796482									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7539	chr2	234763115	234763135	233854469	233854489	83408	hg19					enhancer	enh				GCTGCGCGCCATGGAGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-1.243709511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7540	chr2	234763121	234763141	233854475	233854495	83409	hg19					enhancer	enh				GGGTACGCTGCGCGCCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-1.424077891									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7541	chr2	234763124	234763144	233854478	233854498	83410	hg19					enhancer	enh				GCTGGGTACGCTGCGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.196557428									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7542	chr2	234763125	234763146	233854479	233854500	83411	hg19					enhancer	enh				GGCGCGCAGCGTACCCAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-3.440102547									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7543	chr2	234763126	234763146	233854480	233854500	83412	hg19					enhancer	enh				GCGCGCAGCGTACCCAGCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.742870043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7544	chr2	234763142	234763163	233854496	233854517	83413	hg19					enhancer	enh				GGTACTGGCTGGGTCCGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-3.212959722									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7545	chr2	234763142	234763162	233854496	233854516	83414	hg19					enhancer	enh				GTACTGGCTGGGTCCGATGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-1.407470187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7546	chr2	234763153	234763174	233854507	233854528	83415	hg19					enhancer	enh				GTTGGCGCTTGGGTACTGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-0.584579044									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7547	chr2	234763154	234763174	233854508	233854528	83416	hg19					enhancer	enh				GTTGGCGCTTGGGTACTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-0.965667192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7548	chr2	234763154	234763175	233854508	233854529	83417	hg19					enhancer	enh				GCCAGTACCCAAGCGCCAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.310439999									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7549	chr2	234763158	234763180	233854512	233854534	83418	hg19					enhancer	enh				GTCCGGGTTGGCGCTTGGGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-7.370695417									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7550	chr2	234763172	234763193	233854526	233854547	83419	hg19					enhancer	enh				GCGAGGCCCTGCAGTCCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.484715061									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7551	chr2	234763177	234763198	233854531	233854552	83420	hg19					enhancer	enh				GGCGCGCGAGGCCCTGCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.220771097									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7552	chr2	234763177	234763197	233854531	233854551	83421	hg19					enhancer	enh				GCGCGCGAGGCCCTGCAGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-2.447970704									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7553	chr2	234763323	234763344	233854677	233854698	83422	hg19					enhancer	enh				GCGTGGCTGGAAACTCGGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				-0.739583022									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7554	chr2	234763342	234763364	233854696	233854718	83423	hg19					enhancer	enh				GCCCCAATGTCCGGCGGAAGGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HJURP	indirect	Non Significant	NA				0.193379148									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7555	chr2	238969630	238969650	238060989	238061009	83424	hg19					enhancer	enh				GCTACGGGCCCAGAGCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.121360708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7556	chr2	238969632	238969652	238060991	238061011	83425	hg19					enhancer	enh				GCGCTACGGGCCCAGAGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.274330872									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7557	chr2	238969640	238969661	238060999	238061020	83426	hg19					enhancer	enh				GGCCCGTAGCGCTCCGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.36504866									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7558	chr2	238969641	238969661	238061000	238061020	83427	hg19					enhancer	enh				GCCCGTAGCGCTCCGCGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.021010809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7559	chr2	238969646	238969668	238061005	238061027	83428	hg19					enhancer	enh				GCCTCCTTCCCGCGGAGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.294133049									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7560	chr2	238969656	238969676	238061015	238061035	83429	hg19					enhancer	enh				GGCATCCAGCCTCCTTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-1.949254003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7561	chr2	238969665	238969686	238061024	238061045	83430	hg19					enhancer	enh				GGCTGGATGCCCGGCAGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.074734086									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7562	chr2	238969666	238969686	238061025	238061045	83431	hg19					enhancer	enh				GCTGGATGCCCGGCAGCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.104619368									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7563	chr2	238969708	238969730	238061067	238061089	83432	hg19					enhancer	enh				GGCGCATCCCTCCCCGGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.022888859									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7564	chr2	238969708	238969729	238061067	238061088	83433	hg19					enhancer	enh				GCGCATCCCTCCCCGGCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	direct	Highly Significant	NA				0.682245613									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7565	chr2	238969717	238969738	238061076	238061097	83434	hg19					enhancer	enh				GGAGGGATGCGCCGGCACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.595723988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7566	chr2	238969718	238969738	238061077	238061097	83435	hg19					enhancer	enh				GAGGGATGCGCCGGCACCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.112506346									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7567	chr2	238969731	238969751	238061090	238061110	83436	hg19					enhancer	enh				GGCTGACTCGCCGCGGGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	direct	Highly Significant	NA				0.500468036									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7568	chr2	238969738	238969758	238061097	238061117	83437	hg19					enhancer	enh				GCCGCTGGGCTGACTCGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				-0.070469173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7569	chr2	238969756	238969777	238061115	238061136	83438	hg19					enhancer	enh				GCTGCGGGAAACACAACTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.07432265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-101099	chr2	238969761	238969782	238061120	238061141	83439	hg19	N/A	N/A	N/A	Enhatls108142	enhancer	enh				GGGAAACACAACTCGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	SCLY	indirect	Non Significant	NA				0.015295424	SCLY	chr2	238060923	238099413	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13025
enhrx-lit7570	chr2	240322669	240322689	239400975	239400995	83440	hg19					enhancer	enh				GAAGCATCATGGTTCAACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.599781237									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7571	chr2	240322669	240322691	239400975	239400997	83441	hg19					enhancer	enh				GAGAAGCATCATGGTTCAACGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.053473192									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7572	chr2	240322670	240322691	239400976	239400997	83442	hg19					enhancer	enh				GAGAAGCATCATGGTTCAACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-1.026295596									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7573	chr2	240322680	240322702	239400986	239401008	83443	hg19					enhancer	enh				GCTGGAGTGGGGAGAAGCATCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.250474373									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7574	chr2	240322694	240322714	239401000	239401020	83444	hg19					enhancer	enh				GCCTGGCTCGACGCTGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.722008059									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7575	chr2	240322695	240322717	239401001	239401023	83445	hg19					enhancer	enh				GCCGCCTGGCTCGACGCTGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.830351343									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7576	chr2	240322700	240322720	239401006	239401026	83446	hg19					enhancer	enh				GCGTCGAGCCAGGCGGCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.416677039									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7577	chr2	240322711	240322732	239401017	239401038	83447	hg19					enhancer	enh				GCGGGGTGGCCTATCGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.130876134									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7578	chr2	240322722	240322744	239401028	239401050	83448	hg19					enhancer	enh				GCCACCCCGCACGCCCGTCAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				0.197045682									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7579	chr2	240322765	240322785	239401071	239401091	83449	hg19					enhancer	enh				GCCGGCGGCTCGCCAACCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.268258674									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7580	chr2	240322771	240322791	239401077	239401097	83450	hg19					enhancer	enh				GGCTCGCCAACCATTGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				0.083583639									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7581	chr2	240322784	240322806	239401090	239401112	83451	hg19					enhancer	enh				GACGCAAGGCTGCCGCAGCCAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				0.070063457									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7582	chr2	240322800	240322822	239401106	239401128	83452	hg19					enhancer	enh				GCCCGCAAGGGGAGGTGACGCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				0.058762173									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7583	chr2	240322837	240322859	239401143	239401165	83453	hg19					enhancer	enh				GACGAGCTCTTCATTAGAAACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				-0.353905122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7584	chr2	240322847	240322869	239401153	239401175	83454	hg19					enhancer	enh				GAAGAGCTCGTCAATTACGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	HDAC4	indirect	Non Significant	NA				0.053768363									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-101250	chr2	241375781	241375802	240436364	240436385	83455	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GATCTCGCCGGGCTGCGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.094596167	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375795	241375816	240436378	240436399	83456	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCGGGCTCGGGGCGCTCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	direct	Highly Significant	NA				0.359832107	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375797	241375817	240436380	240436400	83457	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGGCTCGGGGCGCTCCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.515598167	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375805	241375827	240436388	240436410	83458	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGCGCTCCTCCCGGGCCACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.044090964	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375806	241375827	240436389	240436410	83459	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCGCTCCTCCCGGGCCACGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				0.016955155	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375818	241375838	240436401	240436421	83460	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCCCAGCTCCAGCCGTGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.0636439	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375823	241375844	240436406	240436427	83461	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GAAGACGCCCAGCTCCAGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	direct	Highly Significant	NA				0.461092425	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375834	241375855	240436417	240436438	83462	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGGCGTCTTCTGCCCGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				0.190581754	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375835	241375855	240436418	240436438	83463	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGCGTCTTCTGCCCGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.012129369	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375852	241375872	240436435	240436455	83464	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCTCGGCCCAGCGCGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.017036731	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375856	241375876	240436439	240436459	83465	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGCCCAGCGCGCCTGCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.253552332	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375857	241375877	240436440	240436460	83466	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCCCAGCGCGCCTGCAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.290713803	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375862	241375884	240436445	240436467	83467	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GACTCCCGGCCTGCAGGCGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				0.118480554	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375870	241375890	240436453	240436473	83468	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGCTGGGACTCCCGGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.604298719	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375870	241375891	240436453	240436474	83469	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGGCTGGGACTCCCGGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	direct	Highly Significant	NA				0.445330607	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375877	241375897	240436460	240436480	83470	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GGGAGTCCCAGCCCCGGGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.199869891	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-101250	chr2	241375899	241375920	240436482	240436503	83471	hg19	N/A	N/A	N/A	Enhatls108296	enhancer	enh				GCCCCACAGCGCCCCGACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GPC1	indirect	Non Significant	NA				-0.19412289	GPC1	chr2	240435662	240468076	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13176
enhrx-lit7585	chr2	241500275	241500297	240560858	240560880	83472	hg19					enhancer	enh				GCTCTGCCACGCCGGGCGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	direct	Highly Significant	NA				0.27317873									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7586	chr2	241500346	241500366	240560929	240560949	83473	hg19					enhancer	enh				GGAGCCCACGTGCGCCGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				0.045216527									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7587	chr2	241500363	241500383	240560946	240560966	83474	hg19					enhancer	enh				GCGCACCGCGGCCTCCATGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.339939708									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7588	chr2	241500435	241500455	240561018	240561038	83475	hg19					enhancer	enh				GAGGTACGCGGTGCAGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	direct	Highly Significant	NA				0.244712918									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7589	chr2	241500437	241500458	240561020	240561041	83476	hg19					enhancer	enh				GTCTGCACCGCGTACCTCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				0.061517393									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7590	chr2	241500446	241500466	240561029	240561049	83477	hg19					enhancer	enh				GCGTACCTCATGCGGCACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.662540439									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7591	chr2	241500447	241500467	240561030	240561050	83478	hg19					enhancer	enh				GCGGTGCCGCATGAGGTACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				0.146215319									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7592	chr2	241500454	241500476	240561037	240561059	83479	hg19					enhancer	enh				GCTGAGGCCGCGGTGCCGCATG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				0.110051771									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7593	chr2	241500457	241500477	240561040	240561060	83480	hg19					enhancer	enh				GCGGCACCGCGGCCTCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.147906932									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7594	chr2	241500466	241500488	240561049	240561071	83481	hg19					enhancer	enh				GGCCTTCGCCAGGCTGAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-1.423443401									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7595	chr2	241500466	241500487	240561049	240561070	83482	hg19					enhancer	enh				GCCTTCGCCAGGCTGAGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.181283042									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7596	chr2	241500472	241500492	240561055	240561075	83483	hg19					enhancer	enh				GGAAGGCCTTCGCCAGGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	direct	Highly Significant	NA				0.260070939									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7597	chr2	241500474	241500495	240561057	240561078	83484	hg19					enhancer	enh				GCCTGGCGAAGGCCTTCCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-2.430065913									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7598	chr2	241500478	241500500	240561061	240561083	83485	hg19					enhancer	enh				GCCCACCTGGAAGGCCTTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	direct	Highly Significant	NA				0.380028369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7599	chr2	241500563	241500584	240561146	240561167	83486	hg19					enhancer	enh				GGCCGGCTTCGGGATTGGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	direct	Highly Significant	NA				0.250508412									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7600	chr2	241500568	241500588	240561151	240561171	83487	hg19					enhancer	enh				GCCTGTCCCAATCCCGAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				0.171960726									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7601	chr2	241500598	241500618	240561181	240561201	83488	hg19					enhancer	enh				GGGGCGGGTCTCTCTCGTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.007604018									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7602	chr2	241500634	241500654	240561217	240561237	83489	hg19					enhancer	enh				GCAGAGAGGCACTTCCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ANKMY1	indirect	Non Significant	NA				-0.425741353									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7603	chr2	241507835	241507856	240568418	240568439	83490	hg19					enhancer	enh				GCGGCCGAGCGGAGCCCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				0.03062174									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7604	chr2	241507885	241507907	240568468	240568490	83491	hg19					enhancer	enh				GGAAGTCGCGCCGGGAGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				0.146696819									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7605	chr2	241507885	241507906	240568468	240568489	83492	hg19					enhancer	enh				GAAGTCGCGCCGGGAGCCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.457230171									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7606	chr2	241507895	241507916	240568478	240568499	83493	hg19					enhancer	enh				GGCACAACAGGAAGTCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.407514469									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7607	chr2	241507895	241507917	240568478	240568500	83494	hg19					enhancer	enh				GGGCACAACAGGAAGTCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.596562511									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7608	chr2	241507895	241507915	240568478	240568498	83495	hg19					enhancer	enh				GCACAACAGGAAGTCGCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.177570238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7609	chr2	241507973	241507995	240568556	240568578	83496	hg19					enhancer	enh				GCCCATGGATTTCACCTAGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.00229338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7610	chr2	241507977	241507999	240568560	240568582	83497	hg19					enhancer	enh				GCCGGCACTAGGTGAAATCCAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.414531172									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7611	chr2	241507978	241507999	240568561	240568582	83498	hg19					enhancer	enh				GCCGGCACTAGGTGAAATCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				0.010347572									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7612	chr2	241507990	241508011	240568573	240568594	83499	hg19					enhancer	enh				GCGGCCATGGCCGCCGGCACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.585598809									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7613	chr2	241507997	241508018	240568580	240568601	83500	hg19					enhancer	enh				GCACTGCGCGGCCATGGCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				0.029526995									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7614	chr2	241508004	241508024	240568587	240568607	83501	hg19					enhancer	enh				GCAGCAGCACTGCGCGGCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	direct	Highly Significant	NA				0.48218003									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7615	chr2	241508010	241508032	240568593	240568615	83502	hg19					enhancer	enh				GCCTGGCGGCAGCAGCACTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				0.131258957									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7616	chr2	241508077	241508097	240568660	240568680	83503	hg19					enhancer	enh				GCCCGCCCTGGACGTGGCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.030021278									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7617	chr2	241508085	241508105	240568668	240568688	83504	hg19					enhancer	enh				GGAGGCCGAGGCCACGTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	RNPEPL1	indirect	Non Significant	NA				-0.318964197									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-101398	chr2	242041576	242041597	241102161	241102182	83505	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCCGCCGAGTGTTTCACGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.114939108	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041599	242041619	241102184	241102204	83506	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCAGCGACGCAGAGGAACCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.013972794	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041614	242041635	241102199	241102220	83507	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCTGCCCGCCCGCCTGCGACC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.103441749	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041626	242041646	241102211	241102231	83508	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GGGCTTCTCCGGGTCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.04585693	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041629	242041650	241102214	241102235	83509	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCGCGGGCTTCTCCGGGTCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.040903107	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041636	242041657	241102221	241102242	83510	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCTGGGCGCGCGGGCTTCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.756563711	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041647	242041667	241102232	241102252	83511	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GTAAGCTCGAGCTGGGCGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.454990462	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041650	242041671	241102235	241102256	83512	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCCCAGCTCGAGCTTACCTGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-1.102734326	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041655	242041676	241102240	241102261	83513	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GGCCGTCAGGTAAGCTCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.160502105	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-101398	chr2	242041655	242041675	241102240	241102260	83514	hg19	N/A	N/A	N/A	Enhatls108450	enhancer	enh				GCCGTCAGGTAAGCTCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.395332827	MTERF4	chr2	241087098	241102311	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13324
enhrx-lit7618	chr2	242041669	242041691	241102254	241102276	83515	hg19					enhancer	enh				GCTATGGCTGCGTTCGGCCGTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.556138622									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7619	chr2	242041672	242041692	241102257	241102277	83516	hg19					enhancer	enh				GGCCGAACGCAGCCATAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-2.664008889									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7620	chr2	242041680	242041701	241102265	241102286	83517	hg19					enhancer	enh				GCAGCCATAGCGCGGAGAAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-2.420129852									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7621	chr2	242041687	242041708	241102272	241102293	83518	hg19					enhancer	enh				GCTGCCATCTTCTCCGCGCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-1.028713299									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7622	chr2	242041699	242041719	241102284	241102304	83519	hg19					enhancer	enh				GATGGCAGCAGTTACGGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-1.607074537									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7623	chr2	242041706	242041728	241102291	241102313	83520	hg19					enhancer	enh				GCAGTTACGGCGCCGGAAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				-0.062447783									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7624	chr2	242041761	242041781	241102346	241102366	83521	hg19					enhancer	enh				GAACGGCGTCGGTGACGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.031578095									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7625	chr2	242041799	242041819	241102384	241102404	83522	hg19					enhancer	enh				GGTGGATCGTGATTCCGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	direct	Highly Significant	NA				0.997375976									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7626	chr2	242041865	242041885	241102450	241102470	83523	hg19					enhancer	enh				GGGGCCGCCCCTTAGAAAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	MTERFD2	indirect	Non Significant	NA				0.132441892									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7627	chr2	242295620	242295640	241356205	241356225	83524	hg19					enhancer	enh				GCGCAGTCGATTGGCCTGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.091325896									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7628	chr2	242295629	242295649	241356214	241356234	83525	hg19					enhancer	enh				GACGCGGACGCGCAGTCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.176139218									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7629	chr2	242295693	242295713	241356278	241356298	83526	hg19					enhancer	enh				GCCTGCTCCCAACTGCCCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				-0.105127578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7630	chr2	242295710	242295732	241356295	241356317	83527	hg19					enhancer	enh				GGCGACGCCGACGCGAGTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				-0.050625656									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7631	chr2	242295711	242295732	241356296	241356317	83528	hg19					enhancer	enh				GCGACGCCGACGCGAGTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	direct	Highly Significant	NA				0.290194847									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7632	chr2	242295720	242295742	241356305	241356327	83529	hg19					enhancer	enh				GCAGCAGCCGCCAGACTCGCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.131183465									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7633	chr2	242295730	242295751	241356315	241356336	83530	hg19					enhancer	enh				GGCGGCTGCTGCTTGCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.151103893									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7634	chr2	242295731	242295751	241356316	241356336	83531	hg19					enhancer	enh				GCGGCTGCTGCTTGCGACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.107039905									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7635	chr2	242295737	242295759	241356322	241356344	83532	hg19					enhancer	enh				GCTGCTTGCGACTGCGGAGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.003736985									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7636	chr2	242295737	242295758	241356322	241356343	83533	hg19					enhancer	enh				GCTGCTTGCGACTGCGGAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.11463265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7637	chr2	242295760	242295780	241356345	241356365	83534	hg19					enhancer	enh				GCGTCCTCACCGGCCTCGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				0.029553137									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7638	chr2	242295770	242295791	241356355	241356376	83535	hg19					enhancer	enh				GCTCGCCCGCCGCGTCCTCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	FARP2	indirect	Non Significant	NA				-0.050128091									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7639	chr2	242576987	242577007	241637572	241637592	83536	hg19					enhancer	enh				GCGCGCGAGCGGAAATACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-1.153574631									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7640	chr2	242577061	242577082	241637646	241637667	83537	hg19					enhancer	enh				GCCAGCAACGCGACGCGGCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	direct	Highly Significant	NA				0.429579578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7641	chr2	242577066	242577086	241637651	241637671	83538	hg19					enhancer	enh				GCGTCGCGTTGCTGGCCCGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.567776835									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7642	chr2	242577067	242577087	241637652	241637672	83539	hg19					enhancer	enh				GACGGGCCAGCAACGCGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	direct	Highly Significant	NA				0.511949962									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7643	chr2	242577079	242577101	241637664	241637686	83540	hg19					enhancer	enh				GGCCCGTCGGAGCGACGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.348834244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7644	chr2	242577080	242577101	241637665	241637686	83541	hg19					enhancer	enh				GCCCGTCGGAGCGACGCCGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.014553685									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7645	chr2	242577085	242577107	241637670	241637692	83542	hg19					enhancer	enh				GACCCGAGCGGCGTCGCTCCGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	direct	Highly Significant	NA				0.239789629									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7646	chr2	242577090	242577110	241637675	241637695	83543	hg19					enhancer	enh				GCGACGCCGCTCGGGTCAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.62946904									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7647	chr2	242577092	242577113	241637677	241637698	83544	hg19					enhancer	enh				GACGCCGCTCGGGTCAGTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.514005681									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7648	chr2	242577095	242577117	241637680	241637702	83545	hg19					enhancer	enh				GCCGCTCGGGTCAGTCGGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				0.078739181									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7649	chr2	242577102	242577123	241637687	241637708	83546	hg19					enhancer	enh				GGGTCAGTCGGCGGCCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	direct	Highly Significant	NA				0.493598797									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7650	chr2	242577103	242577123	241637688	241637708	83547	hg19					enhancer	enh				GGTCAGTCGGCGGCCGGACT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				0.114023244									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7651	chr2	242577115	242577137	241637700	241637722	83548	hg19					enhancer	enh				GCCGGACTGGGAAGATGGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.257189996									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7652	chr2	242577132	242577153	241637717	241637738	83549	hg19					enhancer	enh				GACGCAGGTGAGGAGTTGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				0.025172666									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7653	chr2	242577153	242577173	241637738	241637758	83550	hg19					enhancer	enh				GGGGTCGGTCTTTCCGCAGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.078663033									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7654	chr2	242577169	242577189	241637754	241637774	83551	hg19					enhancer	enh				GATAAGGCGAGCACCTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.322065438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7655	chr2	242577185	242577206	241637770	241637791	83552	hg19					enhancer	enh				GAGCAGGGGAGGCCAATGATA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.958747589									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7656	chr2	242577200	242577221	241637785	241637806	83553	hg19					enhancer	enh				GCGGCAGCCCGACCCGAGCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	ATG4B	indirect	Non Significant	NA				-0.009057285									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7657	chr2	242674001	242674021	241734586	241734606	83554	hg19					enhancer	enh				GCATTGACGGCTCCGCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	direct	Highly Significant	NA				0.216135644									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7658	chr2	242674003	242674023	241734588	241734608	83555	hg19					enhancer	enh				GGGCGGAGCCGTCAATGCGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	direct	Highly Significant	NA				0.249968928									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7659	chr2	242674007	242674028	241734592	241734613	83556	hg19					enhancer	enh				GGAGCCGTCAATGCGCAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.000910734									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7660	chr2	242674008	242674028	241734593	241734613	83557	hg19					enhancer	enh				GAGCCGTCAATGCGCAGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				0.153417938									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7661	chr2	242674027	242674048	241734612	241734633	83558	hg19					enhancer	enh				GCGGCGTCGCCCCGCCCACTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				0.081580056									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7662	chr2	242674032	242674053	241734617	241734638	83559	hg19					enhancer	enh				GTCGCCCCGCCCACTCCGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.132950578									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7663	chr2	242674035	242674056	241734620	241734641	83560	hg19					enhancer	enh				GCCCCGCCCACTCCGGCTCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.092152265									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7664	chr2	242674040	242674062	241734625	241734647	83561	hg19					enhancer	enh				GCCCACTCCGGCTCGGCGGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.188466188									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7665	chr2	242674045	242674067	241734630	241734652	83562	hg19					enhancer	enh				GCCCAGAGCCGCCGAGCCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-1.980648543									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7666	chr2	242674049	242674070	241734634	241734655	83563	hg19					enhancer	enh				GGCTCGGCGGCTCTGGGCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	direct	Highly Significant	NA				0.228398191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7667	chr2	242674050	242674071	241734635	241734656	83564	hg19					enhancer	enh				GCAGGCCCAGAGCCGCCGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.104132248									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7668	chr2	242674054	242674074	241734639	241734659	83565	hg19					enhancer	enh				GGCGGCTCTGGGCCTGCGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.094494189									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7669	chr2	242674075	242674095	241734660	241734680	83566	hg19					enhancer	enh				GGCGCTGCGGGTTGGAGCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.158819519									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7670	chr2	242674085	242674107	241734670	241734692	83567	hg19					enhancer	enh				GTTGGAGCTCGGGACGTGATCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.531829751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-101538	chr2	242674131	242674151	241734716	241734736	83568	hg19	N/A	N/A	N/A	Enhatls108602	enhancer	enh				GAGCGCTGGGCTGAGGGTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				-0.915704187	D2HGDH	chr2	241734601	241768811	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13464
enhrx-101538	chr2	242674153	242674174	241734738	241734759	83569	hg19	N/A	N/A	N/A	Enhatls108602	enhancer	enh				GTCTGCGGTTCAGCCGCGGGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	D2HGDH	indirect	Non Significant	NA				0.138187868	D2HGDH	chr2	241734601	241768811	0				CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	13464
enhrx-lit7671	chr2	242743201	242743221	241803786	241803806	83570	hg19					enhancer	enh				GGAGCTGGTGCGCGCTGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	direct	Highly Significant	NA				0.448791664									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7672	chr2	242743229	242743251	241803814	241803836	83571	hg19					enhancer	enh				GGTGCGGTTGAAATGCTCGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	direct	Highly Significant	NA				0.533971142									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7673	chr2	242743229	242743250	241803814	241803835	83572	hg19					enhancer	enh				GTGCGGTTGAAATGCTCGTAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	direct	Highly Significant	NA				0.340503615									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7674	chr2	242743247	242743267	241803832	241803852	83573	hg19					enhancer	enh				GCAGCTGCGCCCAGAGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-1.176311313									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7675	chr2	242743247	242743269	241803832	241803854	83574	hg19					enhancer	enh				GCGCAGCTGCGCCCAGAGGGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-1.329352383									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7676	chr2	242743252	242743272	241803837	241803857	83575	hg19					enhancer	enh				GGCGCGCAGCTGCGCCCAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-0.123994165									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7677	chr2	242743257	242743278	241803842	241803863	83576	hg19					enhancer	enh				GCGCAGCTGCGCGCCGAGCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				0.120137558									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7678	chr2	242743257	242743277	241803842	241803862	83577	hg19					enhancer	enh				GCGCAGCTGCGCGCCGAGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				0.083229088									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7679	chr2	242743321	242743341	241803906	241803926	83578	hg19					enhancer	enh				GCTCGCGAGTTCGCGCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-0.587955848									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7680	chr2	242743322	242743342	241803907	241803927	83579	hg19					enhancer	enh				GGCTCGCGAGTTCGCGCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	direct	Highly Significant	NA				0.362243853									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7681	chr2	242743329	242743351	241803914	241803936	83580	hg19					enhancer	enh				GAACTCGCGAGCCTGTGCCTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-0.141729191									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7682	chr2	242743337	242743358	241803922	241803943	83581	hg19					enhancer	enh				GAGCCTGTGCCTGCAGGACGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-0.154686795									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7683	chr2	242743343	242743364	241803928	241803949	83582	hg19					enhancer	enh				GCGCCGCCGTCCTGCAGGCAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				-0.644723359									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7684	chr2	242743407	242743428	241803992	241804013	83583	hg19					enhancer	enh				GTCGGCCTTGCCGGACTGGTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	direct	Highly Significant	NA				0.310855533									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7685	chr2	242743412	242743432	241803997	241804017	83584	hg19					enhancer	enh				GGATGTCGGCCTTGCCGGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GAL3ST2	indirect	Non Significant	NA				0.164026767									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7686	chr2	242752014	242752034	241810919	241810939	83585	hg19					enhancer	enh				GAGGCACAGGACATTGCGAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.645580207									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7687	chr2	242752147	242752169	241811052	241811074	83586	hg19					enhancer	enh				GTGTGCACTCACGGAGCCCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.059598161									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7688	chr2	242752149	242752169	241811054	241811074	83587	hg19					enhancer	enh				GTGCACTCACGGAGCCCTCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	direct	Highly Significant	NA				-0.165735006									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7689	chr2	242752166	242752186	241811071	241811091	83588	hg19					enhancer	enh				GAGACGCGGCCCTGCCAGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				0.630206897									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7690	chr2	242752170	242752192	241811075	241811097	83589	hg19					enhancer	enh				GCTCCAGAGACGCGGCCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.643581338									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7691	chr2	242752180	242752201	241811085	241811106	83590	hg19					enhancer	enh				GGGTCTGCTGCTCCAGAGAC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.051202815									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7692	chr2	242752180	242752200	241811085	241811105	83591	hg19					enhancer	enh				GGTCTGCTGCTCCAGAGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	direct	Highly Significant	NA				0.139302369									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7693	chr2	242752188	242752210	241811093	241811115	83592	hg19					enhancer	enh				GAGCAGCAGACCCGTGTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				0.372947593									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7694	chr2	242752190	242752210	241811095	241811115	83593	hg19					enhancer	enh				GCAGCAGACCCGTGTCCCTC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.004861438									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7695	chr2	242752193	242752214	241811098	241811119	83594	hg19					enhancer	enh				GCAGACCCGTGTCCCTCTGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.274587201									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7696	chr2	242752202	242752222	241811107	241811127	83595	hg19					enhancer	enh				GTTGACCTCCCAGAGGGACA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				0.149558129									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7697	chr2	242752209	242752229	241811114	241811134	83596	hg19					enhancer	enh				GGCCGCAGTTGACCTCCCAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-1.043435494									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7698	chr2	242752209	242752231	241811114	241811136	83597	hg19					enhancer	enh				GAGGCCGCAGTTGACCTCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	direct	Highly Significant	NA				0.127934714									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7699	chr2	242752215	242752236	241811120	241811141	83598	hg19					enhancer	enh				GGTCAACTGCGGCCTCACAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	direct	Highly Significant	NA				0.607310352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7700	chr2	242752216	242752236	241811121	241811141	83599	hg19					enhancer	enh				GTCAACTGCGGCCTCACAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				0.310590602									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7701	chr2	242752249	242752270	241811154	241811175	83600	hg19					enhancer	enh				GCCCTCCAACAAGGGCTGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	indirect	Non Significant	NA				-0.470439785									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7702	chr2	242752293	242752313	241811198	241811218	83601	hg19					enhancer	enh				GGTCAATGCACTCAACACTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	NEU4	direct	Highly Significant	NA				0.126411433									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7703	chr2	242792745	242792767	241850593	241850615	83602	hg19					enhancer	enh				GCAGTGGCATCCCGAAACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	direct	Highly Significant	NA				0.280273993									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7704	chr2	242792823	242792843	241850671	241850691	83603	hg19					enhancer	enh				GAGGCTCCGGGGCGTCAGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	direct	Highly Significant	NA				0.231472058									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7705	chr2	242792832	242792854	241850680	241850702	83604	hg19					enhancer	enh				GCCGTGGCCCTGCCTGACGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	direct	Highly Significant	NA				0.204296549									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7706	chr2	242792844	242792865	241850692	241850713	83605	hg19					enhancer	enh				GGGCCACGGCGCCTTCAGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.446047545									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7707	chr2	242792845	242792865	241850693	241850713	83606	hg19					enhancer	enh				GGCCACGGCGCCTTCAGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.063611659									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7708	chr2	242792851	242792873	241850699	241850721	83607	hg19					enhancer	enh				GGCGCCTTCAGCCCCGGGCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.18146769									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7709	chr2	242792852	242792873	241850700	241850721	83608	hg19					enhancer	enh				GCGCCTTCAGCCCCGGGCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.082967538									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7710	chr2	242792858	242792880	241850706	241850728	83609	hg19					enhancer	enh				GCTGCCTGCGGCCCGGGGCT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.116851886									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7711	chr2	242792865	242792886	241850713	241850734	83610	hg19					enhancer	enh				GCTGCTGCTGCCTGCGGCCC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.052072808									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7712	chr2	242792899	242792919	241850747	241850767	83611	hg19					enhancer	enh				GCAGCAGAGATTCAGGGAGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.085808187									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7713	chr2	242792905	242792926	241850753	241850774	83612	hg19					enhancer	enh				GAGATTCAGGGAGCTGGACG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	direct	Highly Significant	NA				-0.024111751									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7714	chr2	242792920	242792940	241850768	241850788	83613	hg19					enhancer	enh				GGACGCAGGCAGCTCTGTGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.53607829									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7715	chr2	242792924	242792944	241850772	241850792	83614	hg19					enhancer	enh				GCAGGCAGCTCTGTGCTGGC	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.149600055									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7716	chr2	242792963	242792983	241850811	241850831	83615	hg19					enhancer	enh				GCATCTGGCCCTCCCTGTAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.825760423									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7717	chr2	242792974	242792994	241850822	241850842	83616	hg19					enhancer	enh				GTCACCGTCCCCTACAGGGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				-0.50630014									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7718	chr2	242792979	242793000	241850827	241850848	83617	hg19					enhancer	enh				GCAGGTGTCACCGTCCCCTA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.055994026									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7719	chr2	242793018	242793038	241850866	241850886	83618	hg19					enhancer	enh				GCATTGAGACATGAGTCCTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	PDCD1	indirect	Non Significant	NA				0.172710391									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7720	chr20	25388158	25388178	25407522	25407542	83619	hg19					enhancer	enh				GCCGTCTCTGCTCAGCCGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-0.208281518									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7721	chr20	25388180	25388200	25407544	25407564	83620	hg19					enhancer	enh				GTTCTGCCATCTCCGGGGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-2.070418122									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7722	chr20	25388189	25388210	25407553	25407574	83621	hg19					enhancer	enh				GTGAGGTCCCCGCCCCGGAGA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-0.564212227									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7723	chr20	25388228	25388249	25407592	25407613	83622	hg19					enhancer	enh				GCATTCCAAGAGGGGCGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-1.366428043									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7724	chr20	25388269	25388289	25407633	25407653	83623	hg19					enhancer	enh				GCGCCTACGGCGCCCGAAAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-0.72836499									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7725	chr20	25388295	25388315	25407659	25407679	83624	hg19					enhancer	enh				GCCGAACAAAGCTAGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-1.92543994									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7726	chr20	25388295	25388317	25407659	25407681	83625	hg19					enhancer	enh				GCGCCGAACAAAGCTAGCCAAT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	direct	Highly Significant	NA				-1.77328952									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7727	chr20	25388303	25388324	25407667	25407688	83626	hg19					enhancer	enh				GCTTTGTTCGGCGCCAAAGCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				1.331747924									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7728	chr20	25388308	25388329	25407672	25407693	83627	hg19					enhancer	enh				GTTCGGCGCCAAAGCGCGGAG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-0.612955581									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7729	chr20	25388312	25388332	25407676	25407696	83628	hg19					enhancer	enh				GGCGCCAAAGCGCGGAGCGG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-1.115489238									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7730	chr20	25388350	25388372	25407714	25407736	83629	hg19					enhancer	enh				GGCGCTGTAGGACTAGAACGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-1.758877011									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7731	chr20	25388359	25388379	25407723	25407743	83630	hg19					enhancer	enh				GGACTAGAACGAAAGGAGTG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-2.915200504									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7732	chr20	25388422	25388442	25407786	25407806	83631	hg19					enhancer	enh				GTTGGCAAGGCCGCGGGAGT	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-5.192245016									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7733	chr20	25388435	25388455	25407799	25407819	83632	hg19					enhancer	enh				GCGGACGCTTCCCACTCCCG	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-2.476070395									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7734	chr20	25388475	25388496	25407839	25407860	83633	hg19					enhancer	enh				GCAGCTCGCGGATCAGTTCCA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-1.488564988									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-lit7735	chr20	25388489	25388510	25407853	25407874	83634	hg19					enhancer	enh				GAGCTGCATCGCGCGCCCGAA	"Knocking out enhancers resulted in reduced expression of target genes (e.g., GATA1 by 44%, MYC by up to 62%) and impaired cell growth."	Bone; Marrow	K562	GINS1	indirect	Non Significant	NA				-2.345883352									CRISPRi	Systematic mapping of functional enhancer-promoter connections with CRISPR interference	https://doi.org/10.1126/science.aag2445	27708057	
enhrx-151789	chr7	93691129	93691148	94061817	94061836	83635	hg19	N/A	enh24333	N/A	Enhatls162258	ERNA	AC003092.1	5-GUAAUCCAGCGAAUCUGGAA-3	3-UCCAGAUUCGCUGGAUUACT-5			The knockdown of AC003092.1 resulted in decreased proliferation and migration of KIRC cells	Kidney (Renal) Tissue	KIRC cell lines	Fibronectin (FN) and Collagen type 1 (col-1)	direct	Significant	NA					BET1	chr7	93993244	94004382	55738				siRNA	Downregulation of enhancer RNA AC003092.1 is associated with poor prognosis in kidney renal clear cell carcinoma	https://doi.org/10.1038/s41598-024-64431-8	38866983	4601
enhrx-151789	chr7	93690906	93690925	94061594	94061613	83636	hg19	N/A	enh24333	N/A	Enhatls162258	ERNA	AC003092.1	5-CAGCAAUCAACAUAAUCAAA-3	5-UUGAUUAUGUUGAUUGCUG-3			The knockdown of AC003092.1 resulted in decreased proliferation and migration of KIRC cells	Kidney (Renal) Tissue	KIRC cell lines	Fibronectin (FN) and Collagen type 1 (col-1)	direct	Significant	NA					BET1	chr7	93993244	94004382	55738				siRNA	Downregulation of enhancer RNA AC003092.1 is associated with poor prognosis in kidney renal clear cell carcinoma	https://doi.org/10.1038/s41598-024-64431-8	38866983	4601
enhrx-30037	chr11	65244751	65244771	65477280	65477300	83637	hg38	N/A	enh1826	fant38913	Enhatls32635	ERNA	eNEMAL (NEAT1-MALAT1-Locus)	GACCUAACUUGAGCCUUCAGUtt	ACUGAAGGCUCAAGUUAGGUCtt			The knockdown of eNEMAL showed no notable changes in the total NEAT1 expression level but resulted in a significant decrease in the level of NEAT1_2 transcript. This indicates that eNEMAL specifically regulates the long isoform of NEAT1 rather than affecting the overall expression of NEAT1.	Breast Tissue	MCF7	"NEAT1, MALAT1"	indirect	Non Significant	NA					SCYL1	chr11	65525076	65538704	47245				siRNA (small interfering RNA) and GapmeR techniques.	"eNEMAL, an enhancer RNA transcribed from a distal MALAT1 enhancer, promotes NEAT1 long isoform expression"	https://doi.org/10.1371/journal.pone.0251515	34019552	4706
enhrx-30037	chr11	65244521	65244542	65477050	65477071	83638	hg38	N/A	enh1826	N/A	Enhatls32635	ERNA	eNEMAL (NEAT1-MALAT1-Locus)	GGCUCCAAUUCCUCCUGAUUUtt	AAAUCAGGAGGAAUUGGAGCCtt			The knockdown of eNEMAL showed no notable changes in the total NEAT1 expression level but resulted in a significant decrease in the level of NEAT1_2 transcript. This indicates that eNEMAL specifically regulates the long isoform of NEAT1 rather than affecting the overall expression of NEAT1.	Breast Tissue	MCF7	"NEAT1, MALAT1"	indirect	Non Significant	NA					SCYL1	chr11	65525076	65538704	47912				siRNA (small interfering RNA) and GapmeR techniques.	"eNEMAL, an enhancer RNA transcribed from a distal MALAT1 enhancer, promotes NEAT1 long isoform expression"	https://doi.org/10.1371/journal.pone.0251515	34019552	4706
enhrx-106298	chr21	16582336	16582355	15210016	15210035	83639	hg18(originally in literature)	N/A	enh19826	N/A	Enhatls113652	ERNA	NRIP1e3_1	GGCCAGAUCUCCUGUGAUAU	UAUCACAGGAGAUCUGGCCU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	NRIP1	indirect	Non Significant	NA					NRIP1	chr21	14961234	15065815	134548				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	181
enhrx-106298	chr21	16583598	16583617	15211278	15211297	83640	hg18(originally in literature)	N/A	enh19826	N/A	Enhatls113652	ERNA	NRIP1e3_2	GCAUUAGGGUUGAAGUAUAA	UAUACUUCAACCCUAAUGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	NRIP1	indirect	Non Significant	NA					NRIP1	chr21	14961234	15065815	144711				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	181
enhrx-32447	chr11	101048891	101048910	101178160	101178179	83641	hg18(originally in literature)	N/A	enh96245	N/A	Enhatls35232	ERNA	PGRe_1	GCAAAUUCUUUCAUGACAAU	UUGUCAUGAAAGAAUUUGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	PGR	indirect	Non Significant	NA					PGR	chr11	101029623	101129813	46542				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	7116
enhrx-32447	chr11	101049455	101049474	101178724	101178743	83642	hg18(originally in literature)	N/A	enh96245	N/A	Enhatls35232	ERNA	PGRe_2	GCAAAGAUGGAUAGAGAUAG	UAUCUCUAUCCAUCUUUGCC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	PGR	indirect	Non Significant	NA					PGR	chr11	101029623	101129813	46542				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	7116
enhrx-lit7736	chr2	11671517	11671541	11531391	11531415	83643	hg18(originally in literature)					ERNA	GREB1e_1	CAGAGAGAUUCAAGCUUGACGGAAU	AUUCCGUCAAGCUUGAAUCUCUCUG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	GREB1	indirect	Non Significant	NA													siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	
enhrx-88565	chr2	11639338	11639357	11499212	11499231	83644	hg18(originally in literature)	N/A	enh18271	N/A	Enhatls94883	ERNA	GREB1e_2	GGCUGAAUCUGGAGAGAAUG	AUUCUCUCCAGAUUCAGCCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	GREB1	indirect	Non Significant	NA					GREB1	chr2	11482340	11642788	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	491
enhrx-88565	chr2	11639338	11639357	11499212	11499231	83645	hg18(originally in literature)	N/A	enh18271	fant5975	Enhatls94883	ERNA	GREB1e_2	GGCUGAAUCUGGAGAGAAUG	AUUCUCUCCAGAUUCAGCCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	GREB1	indirect	Non Significant	NA					GREB1	chr2	11482340	11642788	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	491
enhrx-88565	chr2	11639644	11639663	11499518	11499537	83646	hg18(originally in literature)	N/A	enh18271	N/A	Enhatls94883	ERNA	GREB1e_3	AGGCAAGAGCAGAUCAAUAA	UAUUGAUCUGCUCUUGCCUG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	GREB1	indirect	Non Significant	NA					GREB1	chr2	11482340	11642788	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	491
enhrx-88565	chr2	11638579	11638598	11498453	11498472	83647	hg18(originally in literature)	N/A	enh18271	N/A	Enhatls94883	ERNA	GREB1e_4	GGACACAACAGUACCUAAAG	UUUAGGUACUGUUGUGUCCC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	GREB1	indirect	Non Significant	NA					GREB1	chr2	11482340	11642788	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	491
enhrx-120044	chr3	150562770	150562789	150844983	150845002	83648	hg18(originally in literature)	N/A	enh21034	N/A	Enhatls128435	ERNA	SIAH2e1_1	GCACAUACCUCAUUAGAGAU	UCUCUAAUGAGGUAUGUGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SIAH2	indirect	Non Significant	NA					MINDY4B	chr3	150870375	150905439	22708				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	8173
enhrx-120044	chr3	150561833	150561852	150844046	150844065	83649	hg18(originally in literature)	N/A	enh21034	N/A	Enhatls128435	ERNA	SIAH2e1_2	CCAGAGAGCUGAACUGAUAA	UAUCAGUUCAGCUCUCUGGG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SIAH2	indirect	Non Significant	NA					MINDY4B	chr3	150870375	150905439	22708				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	8173
enhrx-120042	chr3	150455726	150455745	150737939	150737958	83650	hg18(originally in literature)	N/A	enh7626	N/A	Enhatls128433	ERNA	SIAH2e2_1	GCAGGAAGAAGGAGGACAAA	UUGUCCUCCUUCUUCCUGCG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SIAH2	indirect	Non Significant	NA					SIAH2	chr3	150741124	150763431	3127				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	8171
enhrx-120044	chr3	150582993	150583012	150865206	150865225	83651	hg18(originally in literature)	N/A	enh21035	N/A	Enhatls128435	ERNA	SIAH2e2_2	GGUAUUAAUAGCUCUGAAAU	UUUCAGAGCUAUUAAUACCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SIAH2	indirect	Non Significant	NA					MINDY4B	chr3	150870375	150905439	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	8173
enhrx-107493	chr21	43504422	43504446	42084312	42084336	83652	hg18(originally in literature)	N/A	N/A	N/A	Enhatls114935	ERNA	TFF1e_1	GAGUUUGGACCUGUGACCUUCCUAA	UUAGGAAGGUCACAGGUCCAAACUC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	TFF1	indirect	Non Significant	NA					UMODL1	chr21	42062958	42143453	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1376
enhrx-107492	chr21	43501885	43501909	42081776	42081800	83653	hg18(originally in literature)	N/A	enh34961	N/A	Enhatls114934	ERNA	TFF1e_2	CAAACACAGGAGGUCCUCACUUAAU	AUUAAGUGAGGACCUCCUGUGUUUG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	TFF1	indirect	Non Significant	NA					UMODL1	chr21	42062958	42143453	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1375
enhrx-lit7737	chr21	43504199	43504218	42084089	42084108	83654	hg18(originally in literature)					ERNA	TFF1e_3	UGGAGGAGCCGGAGGAGAAG	UUCUCCUCCGGCUCCUCCAA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	TFF1	indirect	Non Significant	NA													siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	
enhrx-138476	chr6	1641869	1641888	1641635	1641654	83655	hg18(originally in literature)	N/A	enh8915	fant21178	Enhatls148035	ERNA	FOXC1e_1	GCUCCAUUCUGCUGCUCAAG	UUGAGCAGCAGAAUGGAGCG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	FOXC1	indirect	Non Significant	NA					GMDS	chr6	1623805	2245605	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	64
enhrx-138476	chr6	1641536	1641555	1641302	1641321	83656	hg18(originally in literature)	N/A	enh8915	N/A	Enhatls148035	ERNA	FOXC1e_2	CUAACGUGACAGUGACAUAG	UAUGUCACUGUCACGUUAGU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	FOXC1	indirect	Non Significant	NA					GMDS	chr6	1623805	2245605	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	64
enhrx-31140	chr11	72907017	72907036	73195972	73195991	83657	hg18(originally in literature)	N/A	enh1874	N/A	Enhatls33848	ERNA	P2RY2e_1	GCAAAAGGUAGGAGGGUUUU	AAACCCUCCUACCUUUUGCU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	P2RY2	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19662				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	5809
enhrx-31140	chr11	72905132	72905151	73194087	73194106	83658	hg18(originally in literature)	N/A	enh1874	fant39204	Enhatls33848	ERNA	P2RY2e_2	GGAGAUGAAUUGAUAGAGAG	UCUCUAUCAAUUCAUCUCCU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	P2RY2	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24056				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	5809
enhrx-31140	chr11	72905640	72905659	73194595	73194614	83659	hg18(originally in literature)	N/A	enh1874	N/A	Enhatls33848	ERNA	P2RY2e_3	GGAUAAAGCUGGAGUGAGUU	ACUCACUCCAGCUUUAUCCC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	P2RY2	direct	Significant	NA					P2RY2	chr11	73218280	73242427	23544				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	5809
enhrx-31140	chr11	72904797	72904816	73193752	73193771	83660	hg18(originally in literature)	N/A	enh1874	N/A	Enhatls33848	ERNA	P2RY2e_4	GCAUAAAGCCUCAGUGACAU	UGUCACUGAGGCUUUAUGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	P2RY2	direct	Significant	NA					P2RY2	chr11	73218280	73242427	24376				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	5809
enhrx-lit7738	chr15	63679775	63679794	63387576	63387595	83661	hg18(originally in literature)					ERNA	CA12e_1	CAGAAGAGCUAUUUGGUAUG	AUACCAAAUAGCUCUUCUGU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	CA12	indirect	Non Significant	NA													siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	
enhrx-56744	chr15	63680355	63680374	63388156	63388175	83662	hg18(originally in literature)	N/A	enh16223	N/A	N/A	ERNA	CA12e_2	GAGUGGACUUCACAAGAAAG	UUUCUUGUGAAGUCCACUCU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	CA12	indirect	Non Significant	NA					CA12	chr15	63321377	63381846	6141				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	3446
enhrx-77958	chr18	46500959	46500978	48974589	48974608	83663	hg18(originally in literature)	N/A	enh17686	N/A	Enhatls83638	ERNA	SMAD7e1_1	AGAGAAGAAUGAAGGUGAA	UUCACCUUCAUUCUUCUCUC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SMAD7	indirect	Non Significant	NA					SMAD7	chr18	48919852	48950965	15640				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1976
enhrx-77958	chr18	46501652	46501671	48975282	48975301	83664	hg18(originally in literature)	N/A	enh17686	N/A	Enhatls83638	ERNA	SMAD7e1_2	ACUUAAAGGUUCCAGUGUUC	AACACUGGAACCUUUAAGUC			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SMAD7	indirect	Non Significant	NA					SMAD7	chr18	48919852	48950965	15640				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1976
enhrx-77958	chr18	46508984	46509003	48982614	48982633	83665	hg18(originally in literature)	N/A	enh17686	N/A	Enhatls83638	ERNA	SMAD7e2_1	CCACAGGUGAGCAGAAAUUC	AAUUUCUGCUCACCUGUGGA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SMAD7	indirect	Non Significant	NA					SMAD7	chr18	48919852	48950965	31504				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1976
enhrx-77958	chr18	46510327	46510346	48983957	48983976	83666	hg18(originally in literature)	N/A	enh17686	N/A	Enhatls83638	ERNA	SMAD7e2_2	GCUGAUGAAAGGAAGGAAAA	UUUCCUUCCUUUCAUCAGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	SMAD7	indirect	Non Significant	NA					SMAD7	chr18	48919852	48950965	31504				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	1976
enhrx-141077	chr6	39234476	39234495	39266700	39266719	83667	hg18(originally in literature)	N/A	enh23217	N/A	Enhatls150817	ERNA	KCNK5e1_1	CGAAAUGGCCUAAAGAUGAA	UCAUCUUUAGGCCAUUUCGU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	KCNK5	indirect	Non Significant	NA					KCNK17	chr6	39299000	39314461	15302				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	2665
enhrx-141077	chr6	39235752	39235771	39267976	39267995	83668	hg18(originally in literature)	N/A	enh23217	N/A	Enhatls150817	ERNA	KCNK5e1_2	GCAAAGAGCUGGACUUACAG	UGUAAGUCCAGCUCUUUGCA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	KCNK5	indirect	Non Significant	NA					KCNK17	chr6	39299000	39314461	15302				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	2665
enhrx-141077	chr6	39237807	39237826	39270031	39270050	83669	hg18(originally in literature)	N/A	enh23217	N/A	Enhatls150817	ERNA	KCNK5e2_1	ACACAAAGGUGGAAGGAAAG	UUUCCUUCCACCUUUGUGUG			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	KCNK5	indirect	Non Significant	NA					KCNK17	chr6	39299000	39314461	15302				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	2665
enhrx-141077	chr6	39238034	39238053	39270258	39270277	83670	hg18(originally in literature)	N/A	enh23217	N/A	Enhatls150817	ERNA	KCNK5e2_2	CCACACAGCUGUCCAUAAAA	UUUAUGGACAGCUGUGUGGA			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	KCNK5	indirect	Non Significant	NA					KCNK17	chr6	39299000	39314461	15302				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	2665
enhrx-138477	chr6	1832670	1832689	1832436	1832455	83671	hg18(originally in literature)	N/A	enh22895	N/A	Enhatls148037	ERNA	FOXC1-e222	GAGUCAAAUGCUACAAAUAA	UAUUUGUAGCAUUUGACUCU			"Knockdown of these eRNAs resulted in a significant inhibition of both the eRNA transcription and adjacent coding gene transcription. However, it did not affect distant genes or housekeeping genes like GAPDH"	Breast tissue	MCF-7 cells	FOXC1	indirect	Non Significant	NA					GMDS	chr6	1623805	2245605	0				siRNA (short interfering RNA) and LNA (locked nucleic acid)	Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation	https://doi.org/10.1038/nature12210	23728302	65
enhrx-31140	chr11	72907018	72907037	73195973	73195992	83672	hg19	N/A	enh1874	N/A	Enhatls33848	ERNA	P2RY2 eRNA (P2RY2e)	5'-GCAAAAGGUAGGAGGGUUUU-3'	5'- AAACCCUCCUACCUUUUGCU-3'			"P2RY2e knockdown by CRISPR-Cas13a inhibit the cell multiplication, invasion and migration. Downregulation reduces the malignant characteristics of BCa cells and increases cell apoptosis. It also diminishes the cancer-promoting effects of estrogen."	Bladder Tissue	BCa (Bladder Cancer Cells)	P2RY2	direct	Significant	NA					P2RY2	chr11	73218280	73242427	19662				siRNA	Enhancer RNA - P2RY2e induced by estrogen promotes malignant behaviors of bladder cancer	https://doi.org/10.7150/ijbs.27151	30123075	5809
enhrx-136171	chr5	141724980	141725001	142345415	142345436	83673	hg19	N/A	enh38457	N/A	N/A	ERNA	AC005592.2 se-lncRNA (siRNA-78)	GGAAGCUAGUAGAAGAUUUTTA	AAAUCUUCUACUAGCUUCCTTG			"AC005592.2 knockdown results in decreased CRC cell proliferation, migration, and invasion, while increasing apoptosis. It also leads to increased expression of OLFM4, highlighting its role in regulating important cancer-related processes."	CRC tissues	CRC cells	AC005592.2	direct	Significant	NA					SPRY4	chr5	142310426	142325021	20395				siRNA	Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer	https://doi.org/10.1186/s12885-021-07900-x	33622275	5962
enhrx-136171	chr5	141732915	141732935	142353350	142353370	83674	hg19	N/A	enh22650	N/A	N/A	ERNA	AC005592.2 se-lncRNA (siRNA-273)	GAAUGGCACUUUGGACAAUTT	AUUGUCCAAAGUGCCAUUCTT			"AC005592.2 knockdown results in decreased CRC cell proliferation, migration, and invasion, while increasing apoptosis. It also leads to increased expression of OLFM4, highlighting its role in regulating important cancer-related processes."	CRC tissues	CRC cells	AC005592.2	direct	Significant	NA					SPRY4	chr5	142310426	142325021	28205				siRNA	Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer	https://doi.org/10.1186/s12885-021-07900-x	33622275	5962
enhrx-136171	chr5	141733041	141733062	142353476	142353497	83675	hg19	N/A	enh22650	N/A	N/A	ERNA	AC005592.2 se-lncRNA (siRNA-402)	GGAGUAGGCUGACCAGUUATT	UAACUGGUCAGCCUACUCCTTT			"AC005592.2 knockdown results in decreased CRC cell proliferation, migration, and invasion, while increasing apoptosis. It also leads to increased expression of OLFM4, highlighting its role in regulating important cancer-related processes."	CRC tissues	CRC cells	AC005592.2	direct	Significant	NA					SPRY4	chr5	142310426	142325021	28205				siRNA	Super-enhancer-associated long noncoding RNA AC005592.2 promotes tumor progression by regulating OLFM4 in colorectal cancer	https://doi.org/10.1186/s12885-021-07900-x	33622275	5962
enhrx-lit7739	chr14	24408579	24408599	23939370	23939390	83676	hg19					ERNA	AS1eRNA-si1	GUAGUACAUAGAGUCCCUGTT	CAGGGACUCUAUGUACUACTT			"Knockdown of AS1eRNA led to a significant decrease in DHRS4-AS1 expression in both HepG2 and HL7702 cells compared to cells treated with the non-targeting control siRNA, with a greater inhibitory effect in HepG2 cells than in HL7702 cells"	Liver	HepG2 and HL7702 cells	DHRS4	indirect	Non Significant	NA													siRNA	"Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster"	https://doi.org/10.1038/srep20961	26864944	
enhrx-lit7740	chr14	24408246	24408265	23939037	23939056	83677	hg19					ERNA	AS1eRNA-si2	CACUCAGCUUUAACAAACATTA	UGUUUGUUAAAGCUGAGUGTT			"Knockdown of AS1eRNA led to a significant decrease in DHRS4-AS1 expression in both HepG2 and HL7702 cells compared to cells treated with the non-targeting control siRNA, with a greater inhibitory effect in HepG2 cells than in HL7702 cells"	Liver	HepG2 and HL7702 cells	DHRS4	indirect	Non Significant	NA													siRNA	"Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster"	https://doi.org/10.1038/srep20961	26864944	
enhrx-lit7741	chr10	62544593	62544612	60784835	60784854	83678	hg19					ERNA	si-CDK1-1	5?-GGAACTTCGTCATCCAAATA-3?				"CDK1 knockdown or treatment with a CDK1 inhibitor (RO3306) decreased cell proliferation, while CDK1 overexpression partially rescued the growth-inhibitory effect of LINC00880 knockdown."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7742	chr10	62544562	62544581	60784804	60784823	83679	hg19					ERNA	si-CDK1-2	5?-GTACTGCAATTCGGGAAATT-3?				"CDK1 knockdown or treatment with a CDK1 inhibitor (RO3306) decreased cell proliferation, while CDK1 overexpression partially rescued the growth-inhibitory effect of LINC00880 knockdown."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7743	chr10	62545451	62545470	60785693	60785712	83680	hg19					ERNA	si-CDK1-3	5?-GGTTATATCTCATCTTTGAG-3?				"CDK1 knockdown or treatment with a CDK1 inhibitor (RO3306) decreased cell proliferation, while CDK1 overexpression partially rescued the growth-inhibitory effect of LINC00880 knockdown."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-120305	chr3	156819822	156819844	157102033	157102055	83681	hg19	N/A	enh7655	N/A	N/A	ERNA	si-LINC00880-1	5?-ATGAATTCTGGAGGACAAAATTC-3?				"Knockdown of LINC00880 reduces malignant cell phenotypes, decreases cell proliferation, and affects the PTEN-AKT signaling pathway by altering the phosphorylation of PRDX1."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA					CCNL1	chr3	157146507	157160760	44387				siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	8434
enhrx-120305	chr3	156800854	156800876	157083065	157083087	83682	hg19	N/A	enh7655	N/A	N/A	ERNA	si-LINC00880-2	5?-CTCTATGCTAATTTTTTCCAAAA-3?				"Knockdown of LINC00880 reduces malignant cell phenotypes, decreases cell proliferation, and affects the PTEN-AKT signaling pathway by altering the phosphorylation of PRDX1."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA					LEKR1	chr3	156826299	157046129	35533				siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	8434
enhrx-120305	chr3	156800235	156800257	157082446	157082468	83683	hg19	N/A	enh7655	N/A	N/A	ERNA	si-LINC00880-3	5?-ATCTTTTTAGCATCATAGACACT-3?				"Knockdown of LINC00880 reduces malignant cell phenotypes, decreases cell proliferation, and affects the PTEN-AKT signaling pathway by altering the phosphorylation of PRDX1."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA					LEKR1	chr3	156826299	157046129	35533				siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	8434
enhrx-lit7744	chr1	45988402	45988424	45522730	45522752	83684	hg19					ERNA	si-PRDX1-2	5?-ATGTGGAATAGAACAAACTTTAG-3?				"Knockdown of LINC00880 reduces malignant cell phenotypes, decreases cell proliferation, and affects the PTEN-AKT signaling pathway by altering the phosphorylation of PRDX1."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7745	chr1	45988172	45988194	45522500	45522522	83685	hg19					ERNA	si-PRDX1-3	5?-AAGATTGTAAAGTCAAATTATTC-3?				"Knockdown of LINC00880 reduces malignant cell phenotypes, decreases cell proliferation, and affects the PTEN-AKT signaling pathway by altering the phosphorylation of PRDX1."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7746	chrX	49121358	49121380	49264896	49264918	83686	hg19					ERNA	si-FOXP3-1	5?-TCCGTTTAAGTCTCATAATCAAG-3?				"Knockdown of FOXP3 significantly suppresses the expression of LINC00880, subsequently weakening its associated activities, including the involvement of LINC00880 in the malignancy of LUAD."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7747	chrX	49121259	49121281	49264797	49264819	83687	hg19					ERNA	si-FOXP3-2	5?-CTCATCGAAAAAAATTTGGATTA-3?				"Knockdown of FOXP3 significantly suppresses the expression of LINC00880, subsequently weakening its associated activities, including the involvement of LINC00880 in the malignancy of LUAD."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7748	chrX	49121259	49121281	49264797	49264819	83688	hg19					ERNA	si-FOXP3-3	5?-CTCATCGAAAAAAATTTGGATTA-3?				"Knockdown of FOXP3 significantly suppresses the expression of LINC00880, subsequently weakening its associated activities, including the involvement of LINC00880 in the malignancy of LUAD."	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7749	chr2	191864385	191864406	190999659	190999680	83689	hg19					ERNA	si-STAT1	5?-CTGGAAGATTTACAAGATGAATT-3?				The knockdown of STAT1 leads to a significant decrease in the expression of LINC00880	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-lit7750	chr2	191897782	191897802	191033056	191033076	83690	hg19					ERNA	si-STAT4	5?-GCGAGACTACAAAGUUATTATTT-3?				The knockdown of STAT1 leads to a significant decrease in the expression of LINC00880	Lung adenocarcinoma tissue	PC9	CDK1	indirect	Non Significant	NA													siRNA	The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma	https://doi.org/10.1038/s41419-023-06047-w	37620336	
enhrx-95980	chr2	158067644	158067663	157211132	157211151	83691	hg38	N/A	N/A	N/A	Enhatls102747	ERNA	Si-CDK7	CAACAUUGGAUCCUACAUAG	UAUGUAGGAUCCAAUGUUGA			"Knockdown of LIMD1-AS1 inhibited glioma cell proliferation, colony formation, migration, and invasion. It also significantly reduced tumor growth in xenograft mouse models. LIMD1-AS1 knockdown reduced HSPA5 protein levels."	Glioma tissue	"Glioma cells (LN-18, T98G, SF126, PN12, PN16)"	LIMD1	direct	Significant	NA					GALNT5	chr2	157257704	157318491	30032				siRNA	Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression	https://doi.org/10.1038/s41419-023-05892-z	37385987	7906
enhrx-lit7751	chr3	45730243	45730264	45688751	45688772	83692	hg38					ERNA	Si-LIMD1-AS1-1	GCACCUGAGAAGUCUGUAATTGA	UUACAGACUUCUCAGGUGCTTC			"Knockdown of LIMD1-AS1 inhibited glioma cell proliferation, colony formation, migration, and invasion. It also significantly reduced tumor growth in xenograft mouse models. LIMD1-AS1 knockdown reduced HSPA5 protein levels."	Glioma tissue	"Glioma cells (LN-18, T98G, SF126, PN12, PN16)"	LIMD1	direct	Significant	NA													siRNA	Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression	https://doi.org/10.1038/s41419-023-05892-z	37385987	
enhrx-lit7752	chr9	128001052	128001071	125238773	125238792	83693	hg38					ERNA	Si-HSPA5	AGUGUUGGAAGAUUCUGAUU	AUCAGAAUCUUCCAACACUU			"Knockdown of LIMD1-AS1 inhibited glioma cell proliferation, colony formation, migration, and invasion. It also significantly reduced tumor growth in xenograft mouse models. LIMD1-AS1 knockdown reduced HSPA5 protein levels."	Glioma tissue	"Glioma cells (LN-18, T98G, SF126, PN12, PN16)"	LIMD1	direct	Significant	NA													siRNA	Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression	https://doi.org/10.1038/s41419-023-05892-z	37385987	
enhrx-lit7753	chr3	189587113	189587133	189869324	189869344	83694	hg19					ERNA	TP63-shRNA-1			CCGTTTCGTCAGAACACACATG		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA													shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	
enhrx-lit7754	chr3	189507558	189507577	189789769	189789788	83695	hg19					ERNA	TP63-shRNA-2			GGACAGCAGCATTGATCAAT		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA													shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	
enhrx-lit7755	chr3	181430501	181430521	181712713	181712733	83696	hg19					ERNA	SOX2-shRNA-1			CGCTCATGAAGAAGGATAAGT		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA													shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	
enhrx-lit7756	chr3	181432099	181432119	181714311	181714331	83697	hg19					ERNA	SOX2-shRNA-2			CTGCCGAGAATCCATGTATAT		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA													shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	
enhrx-161632	chr8	128220199	128220218	127207954	127207973	83698	hg19	N/A	enh25309	N/A	N/A	ERNA	CCAT1-shRNA-1			GCTTGGGACCACTGCTTTAA		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA					POU5F1B	chr8	127322182	127420066	112468				shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	5423
enhrx-161632	chr8	128220934	128220958	127208689	127208713	83699	hg19	N/A	enh25309	N/A	N/A	ERNA	CCAT1-shRNA-2			CCATTCCATTCATTTCTCTTTCCTA		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA					POU5F1B	chr8	127322182	127420066	112468				shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	5423
enhrx-161632	chr8	128231310	128231329	127219065	127219084	83700	hg19	N/A	enh25309	N/A	Enhatls172629	ERNA	CCAT1-shRNA-3			CATTACCAGCTGCCGTGTTA		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA					POU5F1B	chr8	127322182	127420066	103016				shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	5423
enhrx-161632	chr8	128221684	128221703	127209439	127209458	83701	hg19	N/A	enh25309	N/A	N/A	ERNA	CCAT1-shRNA-4			CGGATGGACATCAGAACTAT		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA					POU5F1B	chr8	127322182	127420066	112468				shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	5423
enhrx-161632	chr8	128220633	128220652	127208388	127208407	83702	hg19	N/A	enh25309	N/A	N/A	ERNA	CCAT1-shRNA-5			GTGAGTGAGATCAGCGTTAT		"CCAT1 knockdown significantly inhibited squamous cancer cell proliferation, migration, and invasion. It resulted in a downregulation of EGFR, which led to reduced activation of the MEK/ERK1/2 and PI3K/AKT signaling pathways."	Squamous cell carcinoma (SCC)	"KYSE, HNSCC, LSCC cell lines"	EGFR	indirect	Significant	NA					POU5F1B	chr8	127322182	127420066	112468				shRNA	Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression	https://doi.org/10.1038/s41467-018-06081-9	30190462	5423
enhrx-lit7757	chrX	134556250	134556269	135422325	135422344	83703	hg19					ERNA	LED-kd1	CCUCGGUGAUGCUUAACGUC				"Knockdown of LED resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. LED knockdown also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA													siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	
enhrx-lit7758	chrX	134232474	134232493	135098444	135098463	83704	hg19					ERNA	LED-kd2	CUUCCCCUACUUCUACAUCG				"Knockdown of LED resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. LED knockdown also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA													siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	
enhrx-1015	chr1	9243723	9243742	9183664	9183683	83705	hg19	N/A	enh26522	N/A	Enhatls1094	ERNA	RP3-510D11.2-KD2	CUCCACCUGCGCAAAACGAA				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA					H6PD	chr1	9234773	9271337	38552				siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	1014
enhrx-1015	chr1	9243744	9243763	9183685	9183704	83706	hg19	N/A	enh26522	N/A	Enhatls1094	ERNA	RP3-510D11.2-KD3	GGGCGGAUUCUCCUUGGACU				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA					H6PD	chr1	9234773	9271337	38552				siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	1014
enhrx-1015	chr1	9251736	9251755	9191677	9191696	83707	hg19	N/A	enh26522	N/A	Enhatls1094	ERNA	RP3-510D11.2-KD4	GCGGCCAUCAGUAACAGCAA				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA					H6PD	chr1	9234773	9271337	38552				siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	1014
enhrx-lit7759	chr5	27477874	27477893	27477767	27477786	83708	hg19					ERNA	LOC643401-KD1	CAGCUCCUGUGGUAAUGUGG				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA													siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	
enhrx-131070	chr5	27485869	27485888	27485762	27485781	83709	hg19	N/A	N/A	N/A	Enhatls140091	ERNA	LOC643401-KD2	UCACCAGGGUGAGUGAACAA				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA					CDH9	chr5	26880596	27121150	356644				siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	861
enhrx-lit7760	chr5	27472411	27472430	27472304	27472323	83710	hg19					ERNA	LOC643401-KD3	GUGUGAGGUGGUGCUAUGUA				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA													siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	
enhrx-lit7761	chr5	27472575	27472594	27472468	27472487	83711	hg19					ERNA	LOC643401-KD4	AGGAGCACAAUUCUGCAACA				"Knockdown resulted in reduced eRNA transcription, lower H3K9 acetylation at enhancers, and diminished p53 binding at target enhancer regions. It also led to reduced induction and activity of the CDKN1A enhancer, which is crucial for p53-mediated cell cycle arrest?"	Breast tissue	MCF-7 cells	CDKN1A gene (p21)	direct	Significantly decreased	NA													siRNA	Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA	https://doi.org/10.1038/ncomms7520	25813522	
enhrx-161618	chr8	126620508	126620529	125608264	125608285	83712	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCM-1	GATCCCGCACATTGTAAGTTGCCAAGCCTCGAGGCTTGGCAACTTACAATGTGCTTTTTGGAT	AGCTATCCAAAAAGCACATTGTAAGTTGCCAAGCCTCGAGGCTTGGCAACTTACAATGTGCGG			"The knockdown of seRNA-NPCM resulted in decreased expression of its associated gene NDRG1, consequently leading to reduced efficacy in promoting the metastasis of NPC cells."	Nasopharyngeal tissue	S26 and S18 cells	N-myc downstream-regulated gene 1 (NDRG1)	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA	JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis	https://doi.org/10.1038/s41419-023-05985-9	37479693	5409
enhrx-161618	chr8	126619537	126619590	125607293	125607346	83713	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCM-2	GATCCCGGAAGATAACACTTTGCAAGACTCGAGTCTTGCAAAGTGTTATCTTCCTTTTTGGAT	AGCTATCCAAAAAGGAAGATAACACTTTGCAAGACTCGAGTCTTGCAAAGTGTTATCTTCCGG			"The knockdown of seRNA-NPCM resulted in decreased expression of its associated gene NDRG1, consequently leading to reduced efficacy in promoting the metastasis of NPC cells."	Nasopharyngeal tissue	S26 and S18 cells	N-myc downstream-regulated gene 1 (NDRG1)	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA	JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis	https://doi.org/10.1038/s41419-023-05985-9	37479693	5409
enhrx-161618	chr8	126618453	126618473	125606209	125606229	83714	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCM-3	GATCCCGCTGGATGCCATTGGTCTATGCTCGAGCATAGACCAATGGCATCCAGCTTTTTGGAT	AGCTATCCAAAAAGCTGGATGCCATTGGTCTATGCTCGAGCATAGACCAATGGCATCCAGCGG			"The knockdown of seRNA-NPCM resulted in decreased expression of its associated gene NDRG1, consequently leading to reduced efficacy in promoting the metastasis of NPC cells."	Nasopharyngeal tissue	S26 and S18 cells	N-myc downstream-regulated gene 1 (NDRG1)	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA	JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis	https://doi.org/10.1038/s41419-023-05985-9	37479693	5409
enhrx-lit7762	chr10	63520727	63520747	61760969	61760989	83715	hg19					ERNA	shARIEL #3			ATCAAGTCACAGATGACATTT		"The knockdown of ARIEL leads to a significant decrease in the messenger RNA (mRNA) expression of ARID5B in T-ALL cells, which is accompanied by decreased protein levels of ARID5B."	T-cell acute lymphoblastic leukemia (T-ALL)	T-ALL cell lines (Jurkat and MOLT-4)	ARID5B	direct	Significant	NA													shRNA	The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia	https://doi.org/10.1182/blood.2018874503	31076442	
enhrx-lit7763	chr10	63525795	63525815	61766037	61766057	83716	hg19					ERNA	shARIEL #5			GCTAAACTTCACAGAAACAAA		"The knockdown of ARIEL leads to a significant decrease in the messenger RNA (mRNA) expression of ARID5B in T-ALL cells, which is accompanied by decreased protein levels of ARID5B."	T-cell acute lymphoblastic leukemia (T-ALL)	T-ALL cell lines (Jurkat and MOLT-4)	ARID5B	direct	Significant	NA													shRNA	The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia	https://doi.org/10.1182/blood.2018874503	31076442	
enhrx-43419	chr12	122722621	122722640	122238074	122238093	83717	hg38	N/A	N/A	N/A	Enhatls46877	ERNA	LINC01089				GATAATAATAGCTAACAGGC	"Knockdown of LINC01089 increases the inclusion of DIAPH3 exon 3 which contains an m6A-modification site recognized by IGF2BP3, that increases DIAPH3 mRNA stability."	Liver tissue	Hepatocellular carcinoma (HCC) cells	DIAPH3	direct	Significant	NA					VPS33A	chr12	122229563	122266494	0				siRNA	Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis	https://doi.org/10.1158/0008-5472.CAN-23-0544	37756562	8729
enhrx-43420	chr12	122723462	122723481	122238915	122238934	83718	hg38	N/A	N/A	N/A	Enhatls46878	ERNA	LINC01089				GGGCTAGCAGAGCTATTTCG	"Knockdown of LINC01089 increases the inclusion of DIAPH3 exon 3 which contains an m6A-modification site recognized by IGF2BP3, that increases DIAPH3 mRNA stability."	Liver tissue	Hepatocellular carcinoma (HCC) cells	DIAPH3	direct	Significant	NA					VPS33A	chr12	122229563	122266494	0				siRNA	Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis	https://doi.org/10.1158/0008-5472.CAN-23-0544	37756562	8730
enhrx-43421	chr12	122725132	122725151	122240585	122240604	83719	hg38	N/A	N/A	N/A	Enhatls46879	ERNA	LINC01089				GGTTTCCACTCCTATGAACA	"Knockdown of LINC01089 increases the inclusion of DIAPH3 exon 3 which contains an m6A-modification site recognized by IGF2BP3, that increases DIAPH3 mRNA stability."	Liver tissue	Hepatocellular carcinoma (HCC) cells	DIAPH3	direct	Significant	NA					VPS33A	chr12	122229563	122266494	0				siRNA	Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis	https://doi.org/10.1158/0008-5472.CAN-23-0544	37756562	8731
enhrx-43422	chr12	122727877	122727896	122243330	122243349	83720	hg38	N/A	N/A	N/A	Enhatls46880	ERNA	LINC01089				GGTAGGAGCCTAGGAGGCGG	"Knockdown of LINC01089 increases the inclusion of DIAPH3 exon 3 which contains an m6A-modification site recognized by IGF2BP3, that increases DIAPH3 mRNA stability."	Liver tissue	Hepatocellular carcinoma (HCC) cells	DIAPH3	direct	Significant	NA					VPS33A	chr12	122229563	122266494	0				siRNA	Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis	https://doi.org/10.1158/0008-5472.CAN-23-0544	37756562	8732
enhrx-161618	chr8	126620508	126620529	125608264	125608285	83721	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCm#1	GATCCCGCACATTGTAAGTTGCCAAGCCTCGAGGCTTGGCAACTTACAATGTGCTTTTTGGAT	AGCTATCCAAAAAGCACATTGTAAGTTGCCAAGCCTCGAGGCTTGGCAACTTACAATGTGCGG			Knockdown of seRNA-NPCm in NPC cells impaired the capability of metastasis. Knockdown of either NPM1 or c-Myc resulted in a significant decrease in NDRG1. Further rescue assays showed that overexpression of seRNA-NPCm restored NDRG1 expression that was reduced by knockdown of NPM1 or c-MYC.	Nasopharyngeal carcinoma (NPC)	"NPC cell lines (S18, S26, 6-10B, 5-8F)"	NDRG1 (N-myc downstream regulated gene 1).	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA knockdown and CRISPR interference	Carcinogen-induced super-enhancer RNA promotes nasopharyngeal carcinoma metastasis through NPM1/c-Myc/NDRG1 axis	https://pmc.ncbi.nlm.nih.gov/articles/PMC10492133/	37693164	5409
enhrx-161618	chr8	126619537	126619590	125607293	125607346	83722	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCm#2	GATCCCGGAAGATAACACTTTGCAAGACTCGAGTCTTGCAAAGTGTTATCTTCCTTTTTGGAT	AGCTATCCAAAAAGGAAGATAACACTTTGCAAGACTCGAGTCTTGCAAAGTGTTATCTTCCGG			Knockdown of seRNA-NPCm in NPC cells impaired the capability of metastasis. Knockdown of either NPM1 or c-Myc resulted in a significant decrease in NDRG1. Further rescue assays showed that overexpression of seRNA-NPCm restored NDRG1 expression that was reduced by knockdown of NPM1 or c-MYC.	Nasopharyngeal carcinoma (NPC)	"NPC cell lines (S18, S26, 6-10B, 5-8F)"	NDRG1 (N-myc downstream regulated gene 1).	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA knockdown and CRISPR interference	Carcinogen-induced super-enhancer RNA promotes nasopharyngeal carcinoma metastasis through NPM1/c-Myc/NDRG1 axis	https://pmc.ncbi.nlm.nih.gov/articles/PMC10492133/	37693164	5409
enhrx-161618	chr8	126618453	126618473	125606209	125606229	83723	hg38	N/A	enh10523	N/A	Enhatls172611	ERNA	seRNA-NPCm#3	GATCCCGCTGGATGCCATTGGTCTATGCTCGAGCATAGACCAATGGCATCCAGCTTTTTGGAT	AGCTATCCAAAAAGCTGGATGCCATTGGTCTATGCTCGAGCATAGACCAATGGCATCCAGCGG			Knockdown of seRNA-NPCm in NPC cells impaired the capability of metastasis. Knockdown of either NPM1 or c-Myc resulted in a significant decrease in NDRG1. Further rescue assays showed that overexpression of seRNA-NPCm restored NDRG1 expression that was reduced by knockdown of NPM1 or c-MYC.	Nasopharyngeal carcinoma (NPC)	"NPC cell lines (S18, S26, 6-10B, 5-8F)"	NDRG1 (N-myc downstream regulated gene 1).	direct	Significant	NA					TRIB1	chr8	125430357	125438403	164520				shRNA knockdown and CRISPR interference	Carcinogen-induced super-enhancer RNA promotes nasopharyngeal carcinoma metastasis through NPM1/c-Myc/NDRG1 axis	https://pmc.ncbi.nlm.nih.gov/articles/PMC10492133/	37693164	5409
enhrx-104707	chr20	44633867	44633894	46005228	46005255	83724	hg38	N/A	N/A	fant58788	N/A	ERNA	MMP9 eRNA-1			CCGGGGCTTAGAGTCTAAGCTATCTGCAGATAGCT TAGACTCTAAGCCTT TTTG	AATTCAAAAAGGCTTAGAGTCTAAGCTATCTGCAG ATAGCTTAGACTCTA AGCC	"Knockdown of MMP9 eRNA significantly reduced BRD4 binding at the MMP9 enhancer by 46%. It also led to a 54% reduction in RNA Pol II binding at this enhancer, resulting in a decrease in MMP9 gene expression."	Colorectal Cancer Tissue	SW480	MMP9	indirect	weak Significant	NA					MMP9	chr20	46008907	46016561	3401				shRNA	RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation	https://doi.org/10.1038/s41594-018-0102-0	30076409	3135
enhrx-104707	chr20	44633893	44633916	46005254	46005277	83725	hg38	N/A	N/A	fant58788	N/A	ERNA	MMP9 eRNA-2			CCGGTACGTGAGGGTATATGCTGTTCTCGAGAACA GCATATACCCTCACG TATTTTTG	AATTCAAAAATACGTGAGGGTATATGCTGTTCTCG AGAACAGCATATACC CTCACGTA	"Knockdown of MMP9 eRNA significantly reduced BRD4 binding at the MMP9 enhancer by 46%. It also led to a 54% reduction in RNA Pol II binding at this enhancer, resulting in a decrease in MMP9 gene expression."	Colorectal Cancer Tissue	SW480	MMP9	indirect	weak Significant	NA					MMP9	chr20	46008907	46016561	3401				shRNA	RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation	https://doi.org/10.1038/s41594-018-0102-0	30076409	3135
enhrx-70118	chr17	32579915	32579934	34252896	34252915	83726	hg38	N/A	N/A	fant52389	N/A	ERNA	CCL2 eRNA-1			CCGGCCAACACTCAGAAGCCTATCTGCAGATAGGC TTCTGAGTGTTGGTTTTTG	AATTCAAAAACCAACACTCAGAAGCCTATCTGCAG ATAGGCTTCTGAGTGTTGG	"Knockdown of CCL2 eRNA significantly reduced BRD4 binding at the CCL2 enhancer by 49%. It also led to a 66% reduction in RNA Pol II binding at this enhancer, causing a decrease in CCL2 gene expression."	Colorectal Cancer Tissue	SW480	CCL2	indirect	weak Significant	NA					CCL2	chr17	34255273	34257208	2240				shRNA	RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation	https://doi.org/10.1038/s41594-018-0102-0	30076409	3387
enhrx-lit7764	chr17	18278648	18278702	18375334	18375388	83727	hg38					ERNA	CCL2 eRNA-2			CCGGCCACCAAGTTCATGGTAAACTGCAGTTTACC ATGAACTTGGTGGTTTTTG	AATTCAAAAACCACCAAGTTCATGGTAAACTGCAG TTTACCATGAACTTGGTGG	"Knockdown of CCL2 eRNA significantly reduced BRD4 binding at the CCL2 enhancer by 49%. It also led to a 66% reduction in RNA Pol II binding at this enhancer, causing a decrease in CCL2 gene expression."	Colorectal Cancer Tissue	SW480	CCL2	indirect	weak Significant	NA													shRNA	RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation	https://doi.org/10.1038/s41594-018-0102-0	30076409	
enhrx-103156	chr20	30186476	30186495	31598673	31598692	83728	hg19	N/A	enh19571	N/A	Enhatls110289	ERNA	SE424 KO-5'gRNA-1F				CACCGCAACTGTTGGAGTGTTAGAG	"The knockout of SE424 resulted in a significant reduction in gene transcription. Specifically, the study reported that knocking out Alu elements from the super-enhancer SE424 led to decreased transcription of the linked gene ID1."	cervical cancer tissue	HeLa cells	ID1	direct	Significant	NA					ID1	chr20	31605282	31606515	5551				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1584
enhrx-103156	chr20	30187685	30187705	31599882	31599902	83729	hg19	N/A	N/A	N/A	Enhatls110289	ERNA	SE424 KO-3'gRNA-1F				CACCGCAATAAGAAGGAATGACCGC	"The knockout of SE424 resulted in a significant reduction in gene transcription. Specifically, the study reported that knocking out Alu elements from the super-enhancer SE424 led to decreased transcription of the linked gene ID1."	cervical cancer tissue	HeLa cells	ID1	direct	Significant	NA					ID1	chr20	31605282	31606515	5006				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1584
enhrx-103156	chr20	30186462	30186482	31598659	31598679	83730	hg19	N/A	enh19571	N/A	Enhatls110289	ERNA	SE424 KO-5'gRNA-2F				CACCGTTATACAACATACCAACTGT	"The knockout of SE424 resulted in a significant reduction in gene transcription. Specifically, the study reported that knocking out Alu elements from the super-enhancer SE424 led to decreased transcription of the linked gene ID1."	cervical cancer tissue	HeLa cells	ID1	direct	Significant	NA					ID1	chr20	31605282	31606515	5551				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1584
enhrx-36424	chr12	20579032	20579051	20426098	20426117	83731	hg19	N/A	N/A	N/A	Enhatls39502	ERNA	TE6189 KO-5'gRNA-1F				CACCGAAAATACTTAATGCTGTTG	Knockout led to a reduction in the transcription of AEBP2. qPCR analysis showed a significant decrease in expression compared to control samples?	cervical cancer tissue	HeLa cells	MGST1 and TUBA1B genes	direct	Significant	NA					PDE3A	chr12	20368536	20688583	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1734
enhrx-36424	chr12	20689491	20689510	20536557	20536576	83732	hg19	N/A	N/A	N/A	Enhatls39502	ERNA	TE6189 KO-3'gRNA-1F				CACCGATTAGTCATTGATTAAGCC	Knockout led to a reduction in the transcription of AEBP2. qPCR analysis showed a significant decrease in expression compared to control samples?	cervical cancer tissue	HeLa cells	MGST1 and TUBA1B genes	direct	Significant	NA					PDE3A	chr12	20368536	20688583	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1734
enhrx-36424	chr12	20689330	20689349	20536396	20536415	83733	hg19	N/A	N/A	N/A	Enhatls39502	ERNA	TE6189 KO-3'gRNA-2F				CACCGCTTTAAGTGGATAAATCACA	Knockout led to a reduction in the transcription of AEBP2. qPCR analysis showed a significant decrease in expression compared to control samples?	cervical cancer tissue	HeLa cells	MGST1 and TUBA1B genes	direct	Significant	NA					PDE3A	chr12	20368536	20688583	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	1734
enhrx-30447	chr11	66690476	66690569	66923005	66923098	83734	hg19	N/A	enh57584	N/A	Enhatls33076	ERNA	SE138 KO-5'gRNA-1F				CACCGTGCTCAGCACGCCTCAAGAT	Knockout caused a decrease in SPTBN2 transcription. The transcriptional impact was validated using qPCR experiments?	cervical cancer tissue	HeLa cells	SYT12 gene	direct	Significant	NA					PC	chr11	66848416	66958386	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	5116
enhrx-30447	chr11	66690884	66690903	66923413	66923432	83735	hg19	N/A	enh57584	N/A	Enhatls33076	ERNA	SE138 KO-3'gRNA-1F				CACCGACAGCTCCACCACATGACAC	Knockout caused a decrease in SPTBN2 transcription. The transcriptional impact was validated using qPCR experiments?	cervical cancer tissue	HeLa cells	SYT12 gene	direct	Significant	NA					PC	chr11	66848416	66958386	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	5116
enhrx-30447	chr11	66690939	66690958	66923468	66923487	83736	hg19	N/A	enh57584	N/A	Enhatls33076	ERNA	SE138 KO-3'gRNA-2F				CACCGCCATAGCTGTCTTGTAAGGA	Knockout caused a decrease in SPTBN2 transcription. The transcriptional impact was validated using qPCR experiments?	cervical cancer tissue	HeLa cells	SYT12 gene	direct	Significant	NA					PC	chr11	66848416	66958386	0				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	5116
enhrx-79162	chr19	786108	786128	786108	786128	83737	hg19	N/A	N/A	N/A	Enhatls84916	ERNA	SE351 KO-5'gRNA-1F				CACCGTATCATCCTTGTAGATTCTG	"Knocking down this super-enhancer eRNA resulted in reduced transcription of multiple linked genes, including CFD and CNN2"	cervical cancer tissue	HeLa cells	CFD and CNN2 genes	direct	Significant	NA					PTBP1	chr19	797074	812327	10267				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	132
enhrx-79162	chr19	786516	786535	786516	786535	83738	hg19	N/A	N/A	N/A	Enhatls84916	ERNA	SE351 KO-3'gRNA-1F				CACCGACAGCTTGAATACCTGAGAC	"Knocking down this super-enhancer eRNA resulted in reduced transcription of multiple linked genes, including CFD and CNN3"	cervical cancer tissue	HeLa cells	CFD and CNN2 genes	direct	Significant	NA					PTBP1	chr19	797074	812327	10267				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	132
enhrx-79162	chr19	786628	786648	786628	786648	83739	hg19	N/A	N/A	N/A	Enhatls84916	ERNA	SE351 KO-3'gRNA-2F				CACCGTATATTAGCATGTTTCGGGC	"Knocking down this super-enhancer eRNA resulted in reduced transcription of multiple linked genes, including CFD and CNN4"	cervical cancer tissue	HeLa cells	CFD and CNN2 genes	direct	Significant	NA					PTBP1	chr19	797074	812327	10267				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	132
enhrx-162104	chr8	142101205	142101224	141091106	141091125	83740	hg19	N/A	enh10605	N/A	Enhatls173166	ERNA	PTK2 KO-5'gRNA-1F				CACCGATTGAAGTATGAAAGGTAGG	Knockout of the Alu element within the PTK2 enhancer using CRISPR?Cas9 reduced PTK2 transcription by 65%.	cervical cancer tissue	HeLa cells	TE29256	direct	Significant	NA					DENND3	chr8	141117277	141195808	23663				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	5895
enhrx-162104	chr8	142101509	142101528	141091410	141091429	83741	hg19	N/A	enh10605	N/A	Enhatls173166	ERNA	PTK2 KO-3'gRNA-1F				CACCGAAAAAAAAGGTAGGATGCAG	Knockout of the Alu element within the PTK2 enhancer using CRISPR?Cas9 reduced PTK2 transcription by 65%.	cervical cancer tissue	HeLa cells	TE29256	direct	Significant	NA					DENND3	chr8	141117277	141195808	23663				LNA ASOs (Locked Nucleic Acid Antisense Oligonucleotides)	Complementary Alu sequences mediate enhancer?promoter selectivity	https://doi.org/10.1038/s41586-023-06323-x	37438529	5895
enhrx-lit7765	chr11	62621042	62621227	62853570	62853755	83742	hg38					ERNA	SNHG1 (Small Nucleolar RNA Host Gene 1)	5'-CCUUCUCUCUAAAGCCCAAtt-3'	5'-UUGGGCUUUAGAGAGAAGGtg-3'	ggccagcaccttctctctaaactcgagtttagagagaaggtgctggccttttt		"SNHG1 knockdown significantly repressed colorectal cancer cell growth both in vitro and in vivo. It led to decreased cell proliferation, cell cycle arrest, and increased apoptosis. Knockdown resulted in upregulation of tumor suppressor genes KLF2 and CDKN2B and downregulation of CCND2."	Colorectal cancer tissue	"Colorectal cancer cell lines(HCT-116, HCT-8, SW-480)"	"SNHG1 CCND2, KLF2,CDKN2B"	direct	Significant	NA													shRNA	The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p	https://doi.org/10.1186/s12943-018-0894-x	30266084	
enhrx-lit7766	chr11	62619974	62620289	62852502	62852817	83743	hg38					ERNA	SNHG1 (Small Nucleolar RNA Host Gene 1)	5'-CCUUCUCUCUAAAGCCCAAtt-3'	5'-UUGGGCUUUAGAGAGAAGGtg-3'	ggtttgctgtgtatcacatttctcgagaaatgtgatacacagcaaaccttttt		"SNHG1 knockdown significantly repressed colorectal cancer cell growth both in vitro and in vivo. It led to decreased cell proliferation, cell cycle arrest, and increased apoptosis. Knockdown resulted in upregulation of tumor suppressor genes KLF2 and CDKN2B and downregulation of CCND2."	Colorectal cancer tissue	"Colorectal cancer cell lines(HCT-116, HCT-8, SW-480)"	"SNHG1 CCND2, KLF2,CDKN2B"	direct	Significant	NA													shRNA	The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p	https://doi.org/10.1186/s12943-018-0894-x	30266084